WorldWideScience

Sample records for winnipeg mb canada

  1. Real time data compactor (sparsifier) and 8 megabyte high speed FIFO for HEP

    International Nuclear Information System (INIS)

    Baumbaugh, A.E.; Knickerbocker, K.L.; Wegner, C.R.; Baumbaugh, B.W.; Ruchti, R.

    1985-10-01

    A Video-Data-Acquisition-System (VDAS) has been developed to record image data from a scintillating glass fiber-optic target developed for High Energy Physics. The major components of the VDAS are a flash ADC, a ''real time'' high speed data compactor, and high speed 8 megabyte FIFO memory. The data rates through the system are in excess of 30 megabytes/second. The compactor is capable of reducing the amount of data needed to reconstruct typical images by as much as a factor of 20. The FIFO uses only standard NMOS DRAMS and TTL components to achieve its large size and high speed at relatively low power and cost

  2. 13th North American Caribou Workshop, 25-28 October 2010, Winnipeg, Manitoba, Canada.

    Directory of Open Access Journals (Sweden)

    Rolf Egil Haugerud (editor in chief

    2012-03-01

    Full Text Available The 13th North American Caribou Workshop which was held in Winnipeg, Manitoba, was a great success with more than 400 participants: people from Canada, the United States, Norway and Greenland, representatives from co-management and resource management boards across North America, First Nations, Inuit and Inuvialuit, governmental and non-governmental organisations, private companies, researchers, students and youth. The theme of the Workshop was Sustaining Caribou and their Landscapes – Knowledge to Action and the intent of the organizers was twofold: first, to provide participants with the opportunity to share scientific and traditional knowledge on different subspecies and ecotypes of Rangifer across the circumpolar North, the particularities of the different landscapes and land use management issues; second, to explore innovative ways to transfer knowledge to action, ensuring the long-term persistence of Rangifer throughout its range through the development of better governance structures, sound policies and effective communication.

  3. Food deserts in Winnipeg, Canada: a novel method for measuring a complex and contested construct

    Directory of Open Access Journals (Sweden)

    Joyce Slater

    2017-10-01

    Full Text Available Introduction: "Food deserts" have emerged over the past 20 years as spaces of concern for communities, public health authorities and researchers because of their potential negative impact on dietary quality and subsequent health outcomes. Food deserts are residential geographic spaces, typically in urban settings, where low-income residents have limited or no access to retail food establishments with sufficient variety at affordable cost. Research on food deserts presents methodological challenges including retail food store identification and classification, identification of low-income populations, and transportation and proximity metrics. Furthermore, the complex methods often used in food desert research can be difficult to reproduce and communicate to key stakeholders. To address these challenges, this study sought to demonstrate the feasibility of implementing a simple and reproducible method of identifying food deserts using data easily available in the Canadian context. Methods: This study was conducted in Winnipeg, Canada in 2014. Food retail establishments were identified from Yellow Pages and verified by public health dietitians. We calculated two scenarios of food deserts based on location of the lowest-income quintile population: (a living ≥ 500 m from a national chain grocery store, or (b living ≥ 500 m from a national chain grocery store or a full-service grocery store. Results: The number of low-income residents living in a food desert ranged from 64 574 to 104 335, depending on the scenario used. Conclusion: This study shows that food deserts affect a significant proportion of the Winnipeg population, and while concentrated in the urban core, exist in suburban neighbourhoods also. The methods utilized represent an accessible and transparent, reproducible process for identifying food deserts. These methods can be used for costeffective, periodic surveillance and meaningful engagement with communities, retailers and policy

  4. Regional tree growth and inferred summer climate in the Winnipeg River basin, Canada, since AD 1783

    Science.gov (United States)

    St. George, Scott; Meko, David M.; Evans, Michael N.

    2008-09-01

    A network of 54 ring-width chronologies is used to estimate changes in summer climate within the Winnipeg River basin, Canada, since AD 1783. The basin drains parts of northwestern Ontario, northern Minnesota and southeastern Manitoba, and is a key area for hydroelectric power production. Most chronologies were developed from Pinus resinosa and P. strobus, with a limited number of Thuja occidentalis, Picea glauca and Pinus banksiana. The dominant pattern of regional tree growth can be recovered using only the nine longest chronologies, and is not affected by the method used to remove variability related to age or stand dynamics from individual trees. Tree growth is significantly, but weakly, correlated with both temperature (negatively) and precipitation (positively) during summer. Simulated ring-width chronologies produced by a process model of tree-ring growth exhibit similar relationships with summer climate. High and low growth across the region is associated with cool/wet and warm/dry summers, respectively; this relationship is supported by comparisons with archival records from early 19th century fur-trading posts. The tree-ring record indicates that summer droughts were more persistent in the 19th and late 18th century, but there is no evidence that drought was more extreme prior to the onset of direct monitoring.

  5. Terabytes to Megabytes: Data Reduction Onsite for Remote Limited Bandwidth Systems

    Science.gov (United States)

    Hirsch, M.

    2016-12-01

    Inexpensive, battery-powerable embedded computer systems such as the Intel Edison and Raspberry Pi have inspired makers of all ages to create and deploy sensor systems. Geoscientists are also leveraging such inexpensive embedded computers for solar-powered or other low-resource utilization systems for ionospheric observation. We have developed OpenCV-based machine vision algorithms to reduce terabytes per night of high-speed aurora video data down to megabytes of data to aid in automated sifting and retention of high-value data from the mountains of less interesting data. Given prohibitively expensive data connections in many parts of the world, such techniques may be generalizable to more than just the auroral video and passive FM radar implemented so far. After the automated algorithm decides which data to keep, automated upload and distribution techniques are relevant to avoid excessive delay and consumption of researcher time. Open-source collaborative software development enables data audiences from experts through citizen enthusiasts to access the data and make exciting plots. Open software and data aids in cross-disciplinary collaboration opportunities, STEM outreach and increasing public awareness of the contributions each geoscience data collection system makes.

  6. Perceptions of barriers, facilitators and motivators related to use of prenatal care: A qualitative descriptive study of inner-city women in Winnipeg, Canada.

    Science.gov (United States)

    Heaman, Maureen I; Sword, Wendy; Elliott, Lawrence; Moffatt, Michael; Helewa, Michael E; Morris, Heather; Tjaden, Lynda; Gregory, Patricia; Cook, Catherine

    2015-01-01

    The objective of this qualitative descriptive study was to explore the perceptions of women living in inner-city Winnipeg, Canada, about barriers, facilitators, and motivators related to their use of prenatal care. Individual, semi-structured interviews were conducted in person with 26 pregnant or postpartum women living in inner-city neighborhoods with high rates of inadequate prenatal care. Interviews averaged 67 min in length. Recruitment of participants continued until data saturation was achieved. Inductive content analysis was used to identify themes and subthemes under four broad topics of interest (barriers, facilitators, motivators, and suggestions). Sword's socio-ecological model of health services use provided the theoretical framework for the research. This model conceptualizes service use as a product of two interacting systems: the personal and situational attributes of potential users and the characteristics of health services. Half of the women in our sample were single and half self-identified as Aboriginal. Participants discussed several personal and system-related barriers affecting use of prenatal care, such as problems with transportation and child care, lack of prenatal care providers, and inaccessible services. Facilitating factors included transportation assistance, convenient location of services, positive care provider qualities, and tangible rewards. Women were motivated to attend prenatal care to gain knowledge and skills and to have a healthy baby. Consistent with the theoretical framework, women's utilization of prenatal care was a product of two interacting systems, with several barriers related to personal and situational factors affecting women's lives, while other barriers were related to problems with service delivery and the broader healthcare system. Overcoming barriers to prenatal care and capitalizing on factors that motivate women to seek prenatal care despite difficult living circumstances may help improve use of prenatal

  7. Déserts alimentaires à Winnipeg (Canada : une nouvelle méthodologie de mesure d'un concept complexe et controversé

    Directory of Open Access Journals (Sweden)

    Joyce Slater

    2017-01-01

    Full Text Available Introduction : Les « déserts alimentaires » ont vu le jour dans les 20 dernières années et forment des secteurs préoccupants pour les collectivités, les autorités en santé publique et les chercheurs en raison de leur effet négatif possible sur la qualité de l’alimentation et en raison de leurs conséquences sur la santé. Ce sont des espaces résidentiels, habituellement en milieu urbain, où les résidents à faible revenu n’ont que peu ou pas accès à des établissements de vente au détail d'aliments qui offrent suffisamment de variété à un prix abordable. La recherche sur les déserts alimentaires présente des défis méthodologiques, notamment la façon de repérer et de classer les magasins d’alimentation au détail, la définition de la population à faible revenu ainsi que les paramètres concernant le transport et la proximité. De plus, les méthodes complexes qui sont souvent employées dans la recherche sur les déserts alimentaires peuvent être difficiles à reproduire et à communiquer aux principaux intervenants. Pour surmonter ces difficultés, nous avons voulu montrer qu’on pouvait concevoir une méthode simple et reproductible pour repérer les déserts alimentaires, à l’aide de données facilement accessibles en contexte canadien. Méthodologie : Cette étude a été menée à Winnipeg (Canada en 2014. Les établissements de vente au détail des aliments ont été trouvés à l’aide des Pages Jaunes et vérifiés par des diététistes en santé publique. Nous avons créé deux scénarios sur les déserts alimentaires en fonction de l’emplacement de la population à quintile de revenu le plus faible : a celle qui habitait à 500 m ou plus d’une épicerie appartenant à une chaîne nationale et b celle qui habitait à 500 m ou plus d’une épicerie appartenant à une chaîne nationale ou d’une épicerie à service complet. Résultats : En fonction du scénario utilisé, 64 574 ou 104 335 r

  8. Barriers, motivators and facilitators related to prenatal care utilization among inner-city women in Winnipeg, Canada: a case-control study.

    Science.gov (United States)

    Heaman, Maureen I; Moffatt, Michael; Elliott, Lawrence; Sword, Wendy; Helewa, Michael E; Morris, Heather; Gregory, Patricia; Tjaden, Lynda; Cook, Catherine

    2014-07-15

    The reasons why women do not obtain prenatal care even when it is available and accessible are complex. Despite Canada's universally funded health care system, use of prenatal care varies widely across neighborhoods in Winnipeg, Manitoba, with the highest rates of inadequate prenatal care found in eight inner-city neighborhoods. The purpose of this study was to identify barriers, motivators and facilitators related to use of prenatal care among women living in these inner-city neighborhoods. We conducted a case-control study with 202 cases (inadequate prenatal care) and 406 controls (adequate prenatal care), frequency matched 1:2 by neighborhood. Women were recruited during their postpartum hospital stay, and were interviewed using a structured questionnaire. Stratified analyses of barriers and motivators associated with inadequate prenatal care were conducted, and the Mantel-Haenszel common odds ratio (OR) was reported when the results were homogeneous across neighborhoods. Chi square analysis was used to test for differences in proportions of cases and controls reporting facilitators that would have helped them get more prenatal care. Of the 39 barriers assessed, 35 significantly increased the odds of inadequate prenatal care for inner-city women. Psychosocial issues that increased the likelihood of inadequate prenatal care included being under stress, having family problems, feeling depressed, "not thinking straight", and being worried that the baby would be apprehended by the child welfare agency. Structural barriers included not knowing where to get prenatal care, having a long wait to get an appointment, and having problems with child care or transportation. Attitudinal barriers included not planning or knowing about the pregnancy, thinking of having an abortion, and believing they did not need prenatal care. Of the 10 motivators assessed, four had a protective effect, such as the desire to learn how to protect one's health. Receiving incentives and getting

  9. Barriers, motivators and facilitators related to prenatal care utilization among inner-city women in Winnipeg, Canada: a case–control study

    OpenAIRE

    Heaman, Maureen I; Moffatt, Michael; Elliott, Lawrence; Sword, Wendy; Helewa, Michael E; Morris, Heather; Gregory, Patricia; Tjaden, Lynda; Cook, Catherine

    2014-01-01

    Background The reasons why women do not obtain prenatal care even when it is available and accessible are complex. Despite Canada’s universally funded health care system, use of prenatal care varies widely across neighborhoods in Winnipeg, Manitoba, with the highest rates of inadequate prenatal care found in eight inner-city neighborhoods. The purpose of this study was to identify barriers, motivators and facilitators related to use of prenatal care among women living in these inner-city neig...

  10. Choking Lake Winnipeg

    Science.gov (United States)

    Byrne, J. M.; Little, L. J.; Dodgson, K. A.; MacDonald, R. J.; Graham, J.

    2009-12-01

    The problems of waterway eutrophication and coastal zone hypoxia are reaching epidemic proportions. Fresh water and coastal marine environments around the world are suffering unprecedented pollution loadings. We are developing an education program to address the dramatic need for public, community and K-12 education about the harsh impacts of elevated nutrient loads on fresh and marine water environments. The Lake Winnipeg watershed is adopted as the poster child of fresh water eutrophication in western North America. The watershed, one of the largest on the continent, is in rapid decline due to pollution, population pressures and water diversion. A concerted education program is needed to change personal and society actions that negatively impact the Winnipeg watershed; and the confluence of the watershed - Lake Winnipeg. But the education program goes beyond Lake Winnipeg. Negative impacts of nutrient loads are adversely affecting environments right to the oceans. Major dead zones that are expanding on our continental shelves due to nutrient overloading threaten to coalesce into extensive regions of marine life die-off. This presentation outlines the documentary education production process under development. We are building a series of Public Service Announcements (PSAs) for national television networks. The PSAs will direct educators, stakeholders and citizens to an associated website with educational video clips detailing the issues of eutrophication and hypoxia. The video clips or webisodes, present interviews with leading scientists. The discussions address the causes of the problems, and presents workable solutions to nutrient overloads from a variety of sources. The webisodes are accompanied by notes and advice to teachers on ways and means to use the webisodes in classrooms. The project is fully funed by a group of Canadian Community Foundations, with the understanding the work wil be available free to educators anywhere in the world. Our education

  11. Barriers, motivators and facilitators related to prenatal care utilization among inner-city women in Winnipeg, Canada: a case–control study

    Science.gov (United States)

    2014-01-01

    Background The reasons why women do not obtain prenatal care even when it is available and accessible are complex. Despite Canada’s universally funded health care system, use of prenatal care varies widely across neighborhoods in Winnipeg, Manitoba, with the highest rates of inadequate prenatal care found in eight inner-city neighborhoods. The purpose of this study was to identify barriers, motivators and facilitators related to use of prenatal care among women living in these inner-city neighborhoods. Methods We conducted a case–control study with 202 cases (inadequate prenatal care) and 406 controls (adequate prenatal care), frequency matched 1:2 by neighborhood. Women were recruited during their postpartum hospital stay, and were interviewed using a structured questionnaire. Stratified analyses of barriers and motivators associated with inadequate prenatal care were conducted, and the Mantel-Haenszel common odds ratio (OR) was reported when the results were homogeneous across neighborhoods. Chi square analysis was used to test for differences in proportions of cases and controls reporting facilitators that would have helped them get more prenatal care. Results Of the 39 barriers assessed, 35 significantly increased the odds of inadequate prenatal care for inner-city women. Psychosocial issues that increased the likelihood of inadequate prenatal care included being under stress, having family problems, feeling depressed, “not thinking straight”, and being worried that the baby would be apprehended by the child welfare agency. Structural barriers included not knowing where to get prenatal care, having a long wait to get an appointment, and having problems with child care or transportation. Attitudinal barriers included not planning or knowing about the pregnancy, thinking of having an abortion, and believing they did not need prenatal care. Of the 10 motivators assessed, four had a protective effect, such as the desire to learn how to protect one

  12. MIBS breadboard ready for testing

    Science.gov (United States)

    Leijtens, Johan; de Goeij, Bryan; Boslooper, Erik

    2017-11-01

    MIBS is a spectrometer operating in the thermal infrared wavelength region, designed in frame of the phase A study for the ESA EarthCARE mission as part of the multispectral Imaging instrument MSI, which uses a 2D microbolometer array detector in stead of the more common MCT detectors. Utilization of a microbolometer and using an integrated calibration system, results in a sensor with a size and mass reduction of at least an order of magnitude when compared to currently flying instruments with similar spectral resolution. In order to demonstrate feasiblity a breadboard has been designed, which will be build and aligned in 2006 and will be ready for testing the forth quarter of 2006.

  13. Remote MIB item look-up service

    NARCIS (Netherlands)

    Pras, Aiko; Boros, S.; Helthuis, Bert

    Despite some deficiencies, the Internet management framework is widely deployed and thousands of Management Information Base (MIB) modules have been defined thus far. These modules are used by implementors of agent software, as well as by managers and management applications, to understand the

  14. Therapeutic landscapes of home: Exploring Indigenous peoples' experiences of a Housing First intervention in Winnipeg.

    Science.gov (United States)

    Alaazi, Dominic A; Masuda, Jeffrey R; Evans, Joshua; Distasio, Jino

    2015-12-01

    In this paper, we explore Indigenous perspectives of culture, place, and health among participants in a landmark Canadian Housing First initiative: At Home/Chez Soi (AHCS) project. Implemented from 2009 to 2013 in Winnipeg and four other Canadian cities, AHCS was a multi-city randomized control trial that sought to test the effectiveness of Housing First as a model for addressing chronic homelessness among people living with mental illnesses. As Winnipeg's homeless population is over 70% Indigenous, significant efforts were made to accommodate the culturally specific health, spiritual, and lifestyle preferences of the project's Indigenous participants. While a daunting challenge from an intervention perspective, Winnipeg's experience also provides a unique opportunity to examine how Indigenous participants' experiences can inform improved housing and mental health policy in Canada. In our study, conducted independently from, but with endorsement of the AHCS project, we utilized a case study approach to explore the experiences of the project's Indigenous participants. Data were collected by means of in-depth qualitative interviews with Indigenous participants (N = 14) and key informant project staff and investigators (N = 6). Our exploratory work demonstrates that despite relative satisfaction with the AHCS intervention, Indigenous peoples' sense of place in the city remains largely disconnected from their housing experiences. We found that structural factors, particularly the shortage of affordable housing and systemic erasure of Indigeneity from the urban sociocultural and political landscape, have adversely impacted Indigenous peoples' sense of place and home. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Organic coolant in Winnipeg riverbed sediments

    International Nuclear Information System (INIS)

    Guthrie, J.E.; Acres, O.E.

    1979-03-01

    Between January and May 1977 a prolonged leak of organic coolant occurred from the Whiteshell Nuclear Research Establishment's nuclear reactor, and a minimum of 1450 kg of coolant entered the Winnipeg River and was deposited on the riverbed. The level of radioactivity associated with this coolant was low, contributing less than 0.2 μGy (0.02 mrad) a year to the natural background gamma radiation field from the riverbed. The concentration of coolant in the water samples never exceeded 0.02 mg/L, the lower limit of detection. The mortality of crayfish, held in cages where the riverbed was covered with the largest deposits of coolant, was not significantly different from that in the control cages upstream of the outfall. No evidence of fish kill was found. (author)

  16. THE 'FROZEN' HEART OF THE CONTINENT: PLACE-BRANDING WINNIPEG IN CANADIAN CRIME FILMS

    Directory of Open Access Journals (Sweden)

    James Gacek

    2016-08-01

    Full Text Available Brands play an imperative role when representing places, as culture and the people who live and create it are at the core of the brand. Aside from promoting experiences and destinations, place brands enhance culture and identity, and orchestrate space and atmosphere to create a particular ambiance in which societies are immersed. Over the past century, the representation of Canada in fictional film has generally emphasized its northerly location, its imagined wilderness landscape, and inevitably, its harsh winter climate. For films that focus on crime, justice is frequently imagined along the lines of the cinematic western, with frontier lawmen bringing order and the reach of the state to remote frontier outposts. For much of the twentieth century, this cultural depiction of Winnipeg justice remained frozen and unchallenged. However, beginning in the latter decades of the twentieth century, a growing number of independent Canadian crime films have taken up these familiar Hollywood tropes in ways that reflect, refract, and sometimes challenge the dominant construction of crime and justice. I examine how these films construct crime and the places that foster crime by emphasizing aspects of racialized identity, class, and the branding dynamics of the city of Winnipeg. Far from the rugged northwest of mid-century Hollywood cinema, crime is relocated to the contemporary city, and while still shaped by the endless Canadian winter, justice is frequently fraught, and the power of law and order distant and unable to extend the civilizing effects of the state to these new urban frontiers.

  17. Brave New World: Frontware, Megabytes, and Integrated Systems.

    Science.gov (United States)

    McIntyre, Jim

    1991-01-01

    Several experts in the field of college financial administration offer their insights into the emerging relationship between high technology and financial management, focusing on the role of the institution's chief business officer. Topics include efficiency, cost effectiveness, organizational communication, homegrown vs. packaged software…

  18. Influenza 1918 : disease, death, and struggle in Winnipeg

    National Research Council Canada - National Science Library

    Jones, Esylt W

    2007-01-01

    ... communities within the city, including its role in the eruption of the largest labour confrontation in Canadian history, the Winnipeg General Strike of 1919. Arguing that labour historians have largely ignored the impact of infectious disease upon the working class, Jones draws on a wide range of primary sources including mothers' allowance and orphanage case fi...

  19. Influenza 1918: disease, death and struggle in Winnipeg

    National Research Council Canada - National Science Library

    Jones, Esyllt Wynne

    2007-01-01

    ... communities within the city, including its role in the eruption of the largest labour confrontation in Canadian history, the Winnipeg General Strike of 1919. Arguing that labour historians have largely ignored the impact of infectious disease upon the working class, Jones draws on a wide range of primary sources including mothers' allowance and orphanage case fi...

  20. Florida-specific NTCIP management information base (MIB) for closed-circuit television (CCTV) camera : final draft.

    Science.gov (United States)

    2009-01-01

    Description: This following MIB has been developed for use by FDOT. This : proposed Florida-Specific NTCIP Management Information Base (MIB) For : Closed-Circuit Television (CCTV) Camera MIB is based on the following : documentations: : NTCIP 120...

  1. Canada

    International Nuclear Information System (INIS)

    Thexton, H.E.

    1987-01-01

    The development of CANDU (Canada Deuterium Uranium) type reactors in Canada is traced. What is CANDU? and how does it differ from a pressurized water reactor? Whey did Canada adopt this design? What factors have led to its success? These questions are asked and answered. First the design itself is explained. Technical problems are considered and figures on operating reliability presented. The economic advantages of CANDU are shown by comparing electricity generating costs at CANDU stations with those at coal-fired stations. Future CANDU options are discussed and prospects for CANDU considered. (U.K.)

  2. 6th Krakow-Winnipeg Conference on Advanced Bioimaging Technologies

    International Nuclear Information System (INIS)

    2011-09-01

    Starting from 1997 researchers have been meet in Krakow, Poland for the Krakow-Winnipeg conference on MRI. The scope of the conference includes the latest technical advances in biomedical imaging including molecular imaging and nanotechnology. Other topics for presentation include recent developments in whole body MRI, multi-transmit technology and gradient-free MRI. Book of Abstracts from the 6 th Conference contains 29 abstracts of Oral Presentations and 11 abstracts of Posters.

  3. Canada

    International Nuclear Information System (INIS)

    Barrett, J.

    1991-01-01

    Canada, while professing a non-nuclear policy for its own armed forces, is, none the less, a member of a nuclear alliance. The security gained through participation in such arrangements does not come cost-free, despite the common view that countries such as Canada enjoy a free ride. Being under the nuclear umbrella, as this paper seeks to illustrate, does generate its own problems and costs. For example, does influence stem from the actual possession of nuclear weapons (albeit under US control), from support of the concept of nuclear deterrence and its infrastructure, or from possessing territory that is of strategic importance to a more powerful ally? Does the Canadian experience serve as a model for countries that are in close proximity to an existing or threshold nuclear power? Much depends on the willingness of a country to participate in the nuclear infrastructure associated with the acquisition of nuclear weapons for security purposes. It must accept the underlying rationale or logic of nuclear deterrence and the constraints on alternative security options that this imposes and it must also recognize that reliance on nuclear deterrence for military security seven if one seeks to emulate Canada and become a non-nuclear weapon state in a nuclear alliance can produce strains in its own right. The case of Canada shows that a country seeking security through such means should be aware of, and reflect upon, the fact that what appears to be a free ride does not come free of charge. However, a country may have other options in it, military security that have neither historically or geostrategically been available to Canada

  4. Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway.

    Science.gov (United States)

    Mizoguchi, Takamasa; Ikeda, Shoko; Watanabe, Saori; Sugawara, Michiko; Itoh, Motoyuki

    2017-10-31

    Persistent directional cell migration is involved in animal development and diseases. The small GTPase Rac1 is involved in F-actin and focal adhesion dynamics. Local Rac1 activity is required for persistent directional migration, whereas global, hyperactivated Rac1 enhances random cell migration. Therefore, precise control of Rac1 activity is important for proper directional cell migration. However, the molecular mechanism underlying the regulation of Rac1 activity in persistent directional cell migration is not fully understood. Here, we show that the ubiquitin ligase mind bomb 1 (Mib1) is involved in persistent directional cell migration. We found that knockdown of MIB1 led to an increase in random cell migration in HeLa cells in a wound-closure assay. Furthermore, we explored novel Mib1 substrates for cell migration and found that Mib1 ubiquitinates Ctnnd1. Mib1-mediated ubiquitination of Ctnnd1 K547 attenuated Rac1 activation in cultured cells. In addition, we found that posterior lateral line primordium cells in the zebrafish mib1 ta52b mutant showed increased random migration and loss of directional F-actin-based protrusion formation. Knockdown of Ctnnd1 partially rescued posterior lateral line primordium cell migration defects in the mib1 ta52b mutant. Taken together, our data suggest that Mib1 plays an important role in cell migration and that persistent directional cell migration is regulated, at least in part, by the Mib1-Ctnnd1-Rac1 pathway. Published under the PNAS license.

  5. Canada

    International Nuclear Information System (INIS)

    Maciej, H.

    1992-01-01

    This paper reports that the Canadian oil and natural gas sector is in for another grim year in 1992. Further streamlining to enhance operating efficiencies and control costs is the first order of the day. About $4 billion worth of producing properties remains on the market, as corporate focus continues to shift to core properties. New management structures put in place in the last two years will be severely tested to improve the sector's financial performance. Massive write-downs in 1990 and 1991 have put balance sheets in much better shape for improved financial performance in the future. Although new long-term debt exceeded redemptions in 1991, largely because of debt- financing of major capital projects, individually most companies are in better shape through significant debt repayment or restructuring. The substantial reductions in interest rates will also help to enhance discretionary cash flow. At this stage, everything appears to be in place to expect that 1992 will represent the bottom of the down-cycle for Canada

  6. Removal of geosmin and 2-methylisorboneol (2-MIB) in water from ...

    African Journals Online (AJOL)

    Geosmin and 2-methylisorboneol (2-MIB) are major organic pollutants ... The use of granular activated carbon (GAC) in the removal of geosmin and 2-MIB is ... were extracted from water samples by solid phase micro-extraction (SPME) and ...

  7. Granular activated carbon adsorption of MIB in the presence of dissolved organic matter.

    Science.gov (United States)

    Summers, R Scott; Kim, Soo Myung; Shimabuku, Kyle; Chae, Seon-Ha; Corwin, Christopher J

    2013-06-15

    Based on the results of over twenty laboratory granular activated carbon (GAC) column runs, models were developed and utilized for the prediction of 2-methylisoborneol (MIB) breakthrough behavior at parts per trillion levels and verified with pilot-scale data. The influent MIB concentration was found not to impact the concentration normalized breakthrough. Increasing influent background dissolved organic matter (DOM) concentration was found to systematically decrease the GAC adsorption capacity for MIB. A series of empirical models were developed that related the throughput in bed volumes for a range of MIB breakthrough targets to the influent DOM concentration. The proportional diffusivity (PD) designed rapid small-scale column test (RSSCT) could be directly used to scale-up MIB breakthrough performance below 15% breakthrough. The empirical model to predict the throughput to 50% breakthrough based on the influent DOM concentration served as input to the pore diffusion model (PDM) and well-predicted the MIB breakthrough performance below a 50% breakthrough. The PDM predictions of throughput to 10% breakthrough well simulated the PD-RSSCT and pilot-scale 10% MIB breakthrough. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. MIB-producing cyanobacteria (Planktothrix sp.) in a drinking water reservoir: distribution and odor producing potential.

    Science.gov (United States)

    Su, Ming; Yu, Jianwei; Zhang, Junzhi; Chen, Hui; An, Wei; Vogt, Rolf D; Andersen, Tom; Jia, Dongmin; Wang, Jingshi; Yang, Min

    2015-01-01

    The production of odorant 2-methylisoborneol (MIB) in water bodies by Planktothrix sp. have not been understood very well. Through a four-year investigation in Miyun Reservoir, a huge mesotrophic drinking water reservoir known to have the MIB episodes, we found that the Planktothrix sp. bloomed during September and October causing the high levels of MIB in the reservoir. The concentration of MIB and the biomass of MIB-producing cyanobacteria Planktothrix were measured (n = 887) at different sites and depths during different seasons. The results indicated that the shallow region of the reservoir is the major habitat for Planktothrix sp. due to that the light is able to penetrate down to the relatively high concentrations of nutrients close to the sediments. Quantile regression analysis between Planktothrix biomass and MIB concentration shows that the risk of MIB exceeding the odor threshold (15 ng L⁻¹) in water was as high as 90% when the Planktothrix density was more than 4.0 × 10⁵ cells L⁻¹, while the risk was reduced to 10% when the Planktothrix density remained below 1.6 × 10⁴ cells L⁻¹. This study will improve the understanding of the environmental behaviors of Planktothrix sp., and can provide useful information for better management of drinking water lakes/reservoirs experiencing the taste and odor (T&O) problems caused by deep living cyanobacterial species.

  9. Immigrant families in historical perspective: the experiences of Polish pioneers in Winnipeg, 1896-1919

    OpenAIRE

    ŁUKASZ ALBAŃSKI

    2017-01-01

    This paper focuses on an early Polish family life in Winnipeg. The family often served as a mechanism to reduce a sense of dislocation and to facilitate immigrants' adaptation. The family was also the primary economic unit. The family relations were affected by gender. Both immigrant men and women found themselves reconsidering traditional roles. Somehow immigration tested their family roles in newways.

  10. Personality differences between users of wine, beer and spirits in a community sample: the Winnipeg Health and Drinking Survey.

    Science.gov (United States)

    McGregor, Darcy; Murray, Robert P; Barnes, Gordon E

    2003-09-01

    To date there are many studies describing the protective and risk factors associated with alcohol consumption and cardiovascular health (the U- or J-shaped curve). These studies have only accounted for part of the effects. One hypothesis is that personality differences may account for some of the unexplained variance. It is also unclear if wine, beer and distilled spirits have equivalent effects on health. The purpose of this study is to describe the differences in personality among users of wine, beer and spirits. Data were from a community sample of 1,257 men and women in Winnipeg, Manitoba, Canada, that was first enrolled in 1989-90. We examined and compared the demographic and personality characteristics of wine, beer and spirits drinkers in this sample. The groups differed significantly on the dimensions of extraversion, psychoticism and reducer-augmenter in univariate tests. In multivariate models, for the total sample and for females, predominant drinking of wine was associated with low scores on the Vando scale (augmenters). Higher consumption of beer among males was associated with higher levels of neuroticism. In these instances, personality does contribute to the characterization of groups.

  11. ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor

    Directory of Open Access Journals (Sweden)

    Nurhayati H Munawer

    2012-12-01

    Full Text Available Background: Phyllodes tumors (PT are rare. We evaluated the expression status of ER, Bcl2, p53, and MIB-1 protein in these tumors. Methods: One hundred and ninety-three tumors were examined using immunohistochemistry on tissue microarray. Results: ERβ (p <0.001, and p53 (p=0.006 in the stromal component were associated with tumor size. p53 expression was significantly associated with both epithelial and stro­mal components of malignant PTs (p<0.05. In PT, the decreased expressions of p53 and MIB-1 were significantly different with positive Bcl2 protein expression in epi­thelial component (p=0.000. Besides, MIB-1 was also found to be associated with ERα and ERβ in stromal component (p=0.000. Conclusion: The expression of p53 with tumor size and histological grade in PTs may increase risk for malignancy.

  12. Clinicopathological significance of p16, cyclin D1, Rb and MIB-1 levels in skull base chordoma and chondrosarcoma

    Directory of Open Access Journals (Sweden)

    Jun-qi Liu

    2015-09-01

    Full Text Available Objective: To investigate the expression of p16, cyclin D1, retinoblastoma tumor suppressor protein (Rb and MIB-1 in skull base chordoma and chondrosarcoma tissues, and to determine the clinicopathological significance of the above indexes in these diseases. Methods: A total of 100 skull base chordoma, 30 chondrosarcoma, and 20 normal cartilage tissue samples were analyzed by immunohistochemistry. The expression levels of p16, cyclinD1, Rb and MIB-1 proteins were assessed for potential correlation with the clinicopathological features. Results: As compared to normal cartilage specimen (control, there was decreased expression of p16, and increased expression of cyclin D1, Rb and MIB-1 proteins, in both skull base chordoma and chondrosarcoma specimens. MIB-1 LI levels were significantly increased in skull base chordoma specimens with negative expression of p16, and positive expression of cyclin D1 and Rb (P  0.05. However, p16 and MIB-1 levels correlated with the intradural invasion, and expression of p16, Rb and MIB-1 correlated with the number of tumor foci (P < 0.05. Further, the expression of p16 and MIB-1 appeared to correlate with the prognosis of patients with skull base chordoma. Conclusions: The abnormal expression of p16, cyclin D1 and Rb proteins might be associated with the tumorigenesis of skull base chordoma and chondrosarcoma. Keywords: p16, Cyclin D1, Rb, MIB-1, Skull base chordoma, Skull base chondrosarcoma

  13. Immigrant families in historical perspective: the experiences of Polish pioneers in Winnipeg, 1896-1919

    Directory of Open Access Journals (Sweden)

    ŁUKASZ ALBAŃSKI

    2017-10-01

    Full Text Available This paper focuses on an early Polish family life in Winnipeg. The family often served as a mechanism to reduce a sense of dislocation and to facilitate immigrants' adaptation. The family was also the primary economic unit. The family relations were affected by gender. Both immigrant men and women found themselves reconsidering traditional roles. Somehow immigration tested their family roles in newways.

  14. 6{sup th} Krakow-Winnipeg Conference on Advanced Bioimaging Technologies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-09-15

    Starting from 1997 researchers have been meet in Krakow, Poland for the Krakow-Winnipeg conference on MRI. The scope of the conference includes the latest technical advances in biomedical imaging including molecular imaging and nanotechnology. Other topics for presentation include recent developments in whole body MRI, multi-transmit technology and gradient-free MRI. Book of Abstracts from the 6{sup th} Conference contains 29 abstracts of Oral Presentations and 11 abstracts of Posters.

  15. Medulloblastoma: evaluation of proliferative index by monoclonal antibody Mib-1, its prognostic correlation and therapeutic implications

    Directory of Open Access Journals (Sweden)

    Ferrari Antonio Fernandes

    2003-01-01

    Full Text Available In the past few years, the monoclonal antibody MIB-1 has been used by researchers in order to retrospectively study paraffin imbibed tumor fragments. The medulloblastoma is the most common malignant central nervous system tumor in childhood. The objectives were: determination of the mean Mib-1 LI value from these patients, as well as the prognostic value of the method.This retrospective study represents an analysis of the cellular proliferation index of posterior fossa medulloblastomas collected from 22 patients at A.C. Camargo Hospital, from January 1990 to December 1999. The histopathological diagnosis was confirmed by H&E and proliferative index (LI was achived with Mib-1 which detects proliferating cells during G1, G2, S and M phases.The results demostrated that the mean Mib-1 was 30,1%, and ranged from 5,2% to 62,0%.In conclusion, this method has prognostic value, has to be used as routine for patients harboring medulloblastomas and the ones who have PI greater than the mean value found in this study, should be treated aggressively.

  16. Stimulation of 2-methylisoborneol (MIB) production by actinomycetes after cyclic chlorination in drinking water distribution systems.

    Science.gov (United States)

    Abbaszadegan, Morteza; Yi, Min; Alum, Absar

    2015-01-01

    The impact of fluctuation in chlorine residual on actinomycetes and the production of 2-methylisoborneol (MIB) were studied in cast-iron and PVC model distribution systems. Actinomycetes were spiked in each system and continued operation for a 12-day non-chlorine experiment, resulting in no changes in actinomycetes and MIB concentrations. Three cyclic chlorination events were performed and chlorine residuals were maintained as follows: 1.0 mg L(-1) for 24 h, 0 mg L(-1) for 48 h, 0.5 mg L(-1) for 48 h, 0 mg L(-1) for 48 h and 2 mg L(-1) for 24 h. After each chlorination event, 2 -3 log decrease in actinomycetes was noted in both systems. However, within 48 h at 0 mg L(-1) chlorine, the actinomycetes recovered to the pre-chlorination levels. On the contrary, MIB concentration in both systems remained un-impacted after the first cycle and increased by fourfold ( 20 mg L(-1)) after the second cycle, which lasted through the third cycle despite the fact that actinomycetes numbers fluctuated 2-3 logs during this time period. For obtaining biofilm samples from field, water meters were collected from municipality drinking water distribution systems located in central Arizona. The actinomycetes concentration in asbestos cement pipe and cast iron pipe averaged 3.1 × 10(3) and 1.9 × 10(4) CFU cm(-2), respectively. The study shows that production of MIB is associated with changes in chlorine residual in the systems. This is the first report of cyclic chlorine shock as a stimulus for MIB production by actinomycetes in drinking water distribution system's ecology.

  17. Defining fish community structure in Lake Winnipeg using stable isotopes (δ{sup 13}C, δ{sup 15}N, δ{sup 34}S): Implications for monitoring ecological responses and trophodynamics of mercury and other trace elements

    Energy Technology Data Exchange (ETDEWEB)

    Ofukany, Amy F.A. [Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, Saskatchewan S7N 5B3 (Canada); Wassenaar, Leonard I. [Environment Canada, 11 Innovation Boulevard, Saskatoon, Saskatchewan S7N 3H5 (Canada); Bond, Alexander L., E-mail: alex.bond@rspb.org.uk [Environment Canada, 11 Innovation Boulevard, Saskatoon, Saskatchewan S7N 3H5 (Canada); Hobson, Keith A. [Environment Canada, 11 Innovation Boulevard, Saskatoon, Saskatchewan S7N 3H5 (Canada)

    2014-11-01

    The ecological integrity of freshwater lakes is influenced by atmospheric and riverine deposition of contaminants, shoreline development, eutrophication, and the introduction of non-native species. Changes to the trophic structure of Lake Winnipeg, Canada, and consequently, the concentrations of contaminants and trace elements measured in tissues of native fishes, are likely attributed to agricultural runoff from the 977,800 km{sup 2} watershed and the arrival of non-native zooplankters and fishes. We measured δ{sup 13}C, δ{sup 15}N, and δ{sup 34}S along with concentrations of 15 trace elements in 17 native fishes from the north and south basins of Lake Winnipeg in 2009 and 2010. After adjusting for differences in isotopic baseline values between the two basins, fishes in the south basin had consistently higher δ{sup 13}C and δ{sup 34}S, and lower δ{sup 15}N. We found little evidence of biomagnification of trace elements at the community level, but walleye (Sander vitreus) and freshwater drum (Aplodinotus grunniens) had higher mercury and selenium concentrations with increased trophic position, coincident with increased piscivory. There was evidence of growth dilution of cobalt, copper, manganese, molybdenum, thallium, and vanadium, and bioaccumulation of mercury, which could be explained by increases in algal (and consequently, lake and fish) productivity. We conclude that the north and south basins of Lake Winnipeg represent very different communities with different trophic structures and trace element concentrations. - Highlights: • Anthropogenic eutrophication and non-native species affect Lake Winnipeg’s ecosystem. • We measured stable isotopes and trace elements in 15 native fish species. • There was more evidence for growth dilution than biomagnification for most elements. • The trophic structures of the north and south basins were different. • These results will help determine the effects of recent arrival of zebra mussels.

  18. Defining fish community structure in Lake Winnipeg using stable isotopes (δ13C, δ15N, δ34S): Implications for monitoring ecological responses and trophodynamics of mercury and other trace elements

    International Nuclear Information System (INIS)

    Ofukany, Amy F.A.; Wassenaar, Leonard I.; Bond, Alexander L.; Hobson, Keith A.

    2014-01-01

    The ecological integrity of freshwater lakes is influenced by atmospheric and riverine deposition of contaminants, shoreline development, eutrophication, and the introduction of non-native species. Changes to the trophic structure of Lake Winnipeg, Canada, and consequently, the concentrations of contaminants and trace elements measured in tissues of native fishes, are likely attributed to agricultural runoff from the 977,800 km 2 watershed and the arrival of non-native zooplankters and fishes. We measured δ 13 C, δ 15 N, and δ 34 S along with concentrations of 15 trace elements in 17 native fishes from the north and south basins of Lake Winnipeg in 2009 and 2010. After adjusting for differences in isotopic baseline values between the two basins, fishes in the south basin had consistently higher δ 13 C and δ 34 S, and lower δ 15 N. We found little evidence of biomagnification of trace elements at the community level, but walleye (Sander vitreus) and freshwater drum (Aplodinotus grunniens) had higher mercury and selenium concentrations with increased trophic position, coincident with increased piscivory. There was evidence of growth dilution of cobalt, copper, manganese, molybdenum, thallium, and vanadium, and bioaccumulation of mercury, which could be explained by increases in algal (and consequently, lake and fish) productivity. We conclude that the north and south basins of Lake Winnipeg represent very different communities with different trophic structures and trace element concentrations. - Highlights: • Anthropogenic eutrophication and non-native species affect Lake Winnipeg’s ecosystem. • We measured stable isotopes and trace elements in 15 native fish species. • There was more evidence for growth dilution than biomagnification for most elements. • The trophic structures of the north and south basins were different. • These results will help determine the effects of recent arrival of zebra mussels

  19. The E3 Ubiquitin Ligase MIB-1 Is Necessary To Form the Nuclear Halo in Caenorhabditis elegans Sperm.

    Science.gov (United States)

    Herrera, Leslie A; Starr, Daniel A

    2018-05-18

    Unlike the classical nuclear envelope with two membranes found in other eukaryotic cells, most nematode sperm nuclei are not encapsulated by membranes. Instead, they are surrounded by a nuclear halo of unknown composition. How the halo is formed and regulated is unknown. We used forward genetics to identify molecular lesions behind three classical fer (fertilization defective) mutations that disrupt the ultrastructure of the Caenorhabditis elegans sperm nuclear halo. We found fer-2 and fer-4 alleles to be nonsense mutations in mib-1. fer-3 was caused by a nonsense mutation in eri-3 GFP::MIB-1 was expressed in the germline during early spermatogenesis, but not in mature sperm. mib-1 encodes a conserved E3 ubiquitin ligase homologous to vertebrate Mib1 and Mib2, which function in Notch signaling. Here, we show that mib-1 is important for male sterility and is involved in the regulation or formation of the nuclear halo during nematode spermatogenesis. Copyright © 2018, G3: Genes, Genomes, Genetics.

  20. A 1000-year record of dry conditions in the eastern Canadian prairies reconstructed from oxygen and carbon isotope measurements on Lake Winnipeg sediment organics

    Science.gov (United States)

    Buhay, W.M.; Simpson, S.; Thorleifson, H.; Lewis, M.; King, J.; Telka, A.; Wilkinson, Philip M.; Babb, J.; Timsic, S.; Bailey, D.

    2009-01-01

    A short sediment core (162 cm), covering the period AD 920-1999, was sampled from the south basin of Lake Winnipeg for a suite of multi-proxy analyses leading towards a detailed characterisation of the recent millennial lake environment and hydroclimate of southern Manitoba, Canada. Information on the frequency and duration of major dry periods in southern Manitoba, in light of the changes that are likely to occur as a result of an increasingly warming atmosphere, is of specific interest in this study. Intervals of relatively enriched lake sediment cellulose oxygen isotope values (??18Ocellulose) were found to occur from AD 1180 to 1230 (error range: AD 1104-1231 to 1160-1280), 1610-1640 (error range: AD 1571-1634 to 1603-1662), 1670-1720 (error range: AD 1643-1697 to 1692-1738) and 1750-1780 (error range: AD 1724-1766 to 1756-1794). Regional water balance, inferred from calculated Lake Winnipeg water oxygen isotope values (??18Oinf-lw), suggest that the ratio of lake evaporation to catchment input may have been 25-40% higher during these isotopically distinct periods. Associated with the enriched d??18Ocellulose intervals are some depleted carbon isotope values associated with more abundantly preserved sediment organic matter (d??13COM). These suggest reduced microbial oxidation of terrestrially derived organic matter and/or subdued lake productivity during periods of minimised input of nutrients from the catchment area. With reference to other corroborating evidence, it is suggested that the AD 1180-1230, 1610-1640, 1670-1720 and 1750-1780 intervals represent four distinctly drier periods (droughts) in southern Manitoba, Canada. Additionally, lower-magnitude and duration dry periods may have also occurred from 1320 to 1340 (error range: AD 1257-1363), 1530-1540 (error range: AD 1490-1565 to 1498-1572) and 1570-1580 (error range: AD 1531-1599 to 1539-1606). ?? 2009 John Wiley & Sons, Ltd.

  1. Regional 500 mb heights and U.S. 1 000-500 mb thickness prior to the radiosonde era

    Science.gov (United States)

    Michaels, P. J.; Sappington, D. E.; Stooksbury, D. E.; Hayden, B. P.

    1990-09-01

    We developed a statistical model relating cyclone track eigenvectors over the U.S., southern Canada, and nearby oceans to a record of mean annual 500 mb heights. The length of the cyclone track record allowed us to calculate mean heights back to 1885. Use of mean annual surface pressure data allowed us to estimate the mean 1 000-500 mb thickness, which was related to mean annual temperature. This temperature calculation is unique in that it cannot suffer from urban or site bias. We find a warming of 1.5°C from the late 19th century to 1955, followed by a drop of 0.7° to 1980. By 1987, the calculated temperatures were 0.3° above the mean for 103 years of record. As an example of regional application, we examine results over the southwestern U.S.

  2. Argyrophilic nucleolar organizer region in MIB-1 positive cells in non-small cell lung cancer: clinicopathological significance and survival

    International Nuclear Information System (INIS)

    Kobyakov, Dmitriy Sergeevich; Avdalyan, Ashot Merudzhanovich; Lazarev, Aleksandr Fedorovich; Lushnikova, Elena Leonidovna; Nepomnyashchikh, Lev Moiseevich

    2014-01-01

    To evaluate the relation between argyrophilic nucleolar organizer region (AgNOR)-associated proteins and clinicopathological parameters and survival in non-small-cell lung cancer (NSCLC). A total of 207 surgical specimens diagnosed as NSCLC were included in this study. Double-staining procedures were performed using antigen Ki-67 (clone MIB-1) and silver nitrate by immunohistochemical and AgNOR-staining methods. The AgNOR area in MIB-1-positive cells of NSCLC is related to clinicopathological parameters under the TNM (tumor, node, and metastasis) system. The survival of patients with small AgNOR area in MIB-1-positive cells is better than that of patients with large AgNOR area. Molecular, biological (AgNOR area in MIB-1-positive cells), and clinicopathological (greatest tumor dimension, metastases to regional lymph nodes, histology, and differentiation) parameters are independent prognostic factors of NSCLC. The AgNOR area in MIB-1-positive cells is related to clinicopathological parameters and survival in NSCLC

  3. Riel Converter Station, Winnipeg: Site selection and environmental assessment status report

    International Nuclear Information System (INIS)

    1991-01-01

    As part of its expansion plans, Manitoba Hydro is planning to construct a converter station east of Winnipeg to receive power from a 850-km dc transmission line which will be constructed to bring power from a new generating station in the north of the province. Work performed to date on site selection and preliminary environmental assessment of the converter station is reviewed. The role of the converter station is described and the potential impacts are summarized in such areas as employment opportunities, pollution and noise during construction, electric and magnetic field effects, and land use impacts. Site selection criteria are outlined and potential sites are identified and evaluated. The Deacon site has been chosen as the preferred site since it has a number of inherent advantages including existing ownership by Manitoba Hydro, proximity to existing transmission rights-of-way, and low visual and land-use impact. 12 figs

  4. Prognostic value of tissue protein expression levels of MIB-1 (Ki-67) in Danish ovarian cancer patients. From the 'MALOVA' ovarian cancer study

    DEFF Research Database (Denmark)

    Heeran, Mel C; Høgdall, Claus K; Kjaer, Susanne K

    2013-01-01

    The primary objective of this study was to assess the expression of MIB-1 (Ki-67) in tumour tissues from 808 patients with epithelial ovarian tumours. The second was to evaluate, whether MIB-1 (Ki-67) tissue expression levels correlate with clinicopathological parameters and prognosis of the dise...

  5. Guideline for energy conservation in de Information, Communication and Technology (ICT) sector. Megabytes versus Megawatt hours; Richtlijn voor energiebesparing in de ICT-branche. Mb versus Mwh

    Energy Technology Data Exchange (ETDEWEB)

    Kester, J.C.P.; Ligthart, F.A.T.M.; Sijpheer, N.C. [ECN Duurzame Energie in de Gebouwde Omgeving DEGO, Petten (Netherlands)

    2001-06-01

    The growth of data traffic to realize telecommunications and internet activities has large impacts on the energy consumption and related CO2 emission. In this report guidelines are given by means of which ICT businesses can quantify their energy consumption and energy saving options can be considered. It also is a first step to exchange of knowledge and information on the subject. At the moment simple and cheap measures can be taken to save 20-40% energy, in particular for cooling purposes.

  6. Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas

    DEFF Research Database (Denmark)

    Jensen, V; Sørensen, Flemming Brandt; Bentzen, S M

    1998-01-01

    . The proliferative activity was assessed by use of the monoclonal antibody MIB-1 and evaluated in multiple, random systematic sampled fields of vision. The percentage of proliferating cells (the MIB-1 index) ranged between 1% and 85% (median 12%). A significant increase in mean MIB-1 index was seen with increasing...... histological malignancy grade. Variation in the incidence of p53 accumulation and bcl-2 positivity among different histological subtypes was observed. p53 accumulation was frequent in synovial sarcomas and leiomyo- and rhabdomyosarcomas, whereas bcl-2 preferentially was expressed in synovial sarcomas....... Univariate analysis identified patient age, tumour size, histological grade of malignancy, MIB-1 index and p53 accumulation as significant prognostic parameters. Multivariate Cox analysis, including tests for interaction terms between histological subtypes and MIB-1 index, showed independent prognostic...

  7. Reinke’s Edema: investigations on the role of MIB-1 and hepatocyte growth factor

    Directory of Open Access Journals (Sweden)

    M. Artico

    2010-07-01

    Full Text Available Reinke’s edema is a benign disease of the human vocal fold, which mainly affects the sub-epithelial layer of the vocal fold. Micro­scopic observations show a strongly oedematous epithelium with loosened intercellular junctions, a disruption of the extracellular connections between mucosal epithelium and connective tissue, closely adherent to the thyroarytenoid muscle. Thickening of the basal layer of epithelium, known as Reinke’s space, high deposition of fibronectin and chronic inflammatory infiltration it is also visible. We analyzed, together with the hepatocyte growth factor (HGF, the expression level of MIB-1 in samples harvested from patients affected by Reinke’s edema, in order to define its biological role and consider it as a possible prognostic factor in the follow-up after surgical treatment. We observed a moderate expression of HGF in the lamina propria of the human vocal fold and in the basal membrane of the mucosal epithelium. Our finding suggests that this growth factor acts as an anti – fibrotic agent in Reinke’s space and affects the fibronectin deposition in the lamina propria. MIB-1, on the contrary, showed a weak expression in the basement membrane of the mucosal epithelium and a total absence in the lamina propria deep layer, thus suggesting that only the superficial layer is actively involved in the reparatory process with a high regenerative capacity, together with a high deposition of fibronectin. The latter is necessary for the cellular connections reconstruction, after the inflammatory infiltration.

  8. Reinke's edema: investigations on the role of MIB-1 and hepatocyte growth factor.

    Science.gov (United States)

    Artico, M; Bronzetti, E; Ionta, B; Bruno, M; Greco, A; Ruoppolo, G; De Virgilio, A; Longo, L; De Vincentiis, M

    2010-07-08

    Reinke's edema is a benign disease of the human vocal fold, which mainly affects the sub-epithelial layer of the vocal fold. Microscopic observations show a strongly oedematous epithelium with loosened intercellular junctions, a disruption of the extracellular connections between mucosal epithelium and connective tissue, closely adherent to the thyroarytenoid muscle. Thickening of the basal layer of epithelium, known as Reinke's space, high deposition of fibronectin and chronic inflammatory infiltration it is also visible. We analyzed, together with the hepatocyte growth factor (HGF), the expression level of MIB-1 in samples harvested from patients affected by Reinke's edema, in order to define its biological role and consider it as a possible prognostic factor in the follow-up after surgical treatment. We observed a moderate expression of HGF in the lamina propria of the human vocal fold and in the basal membrane of the mucosal epithelium. Our finding suggests that this growth factor acts as an antifibrotic agent in Reinke's space and affects the fibronectin deposition in the lamina propria. MIB-1, on the contrary, showed a weak expression in the basement membrane of the mucosal epithelium and a total absence in the lamina propria deep layer, thus suggesting that only the superficial layer is actively involved in the reparatory process with a high regenerative capacity, together with a high deposition of fibronectin. The latter is necessary for the cellular connections reconstruction, after the inflammatory infiltration.

  9. ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor.

    Science.gov (United States)

    Munawer, Nurhayati H; Md Zin, Reena; Md Ali, Siti-Aishah; Muhammad, Rohaizak; Ali, Jasmi; Das, Srijit

    2012-01-01

    Fibroadenomas (FA) are common while phyllodes tumors (PT) are rare and both tumors are composed of epithelial and stromal components. We evaluated the expression status of ER, Bc12, p53, and MIB-1 protein in these tumors. One hundred and ninety-three tumors comprising of 117 FAs and 76 PTs were examined using immunohistochemistry on tissue microarray. The mean age of patients with FA was 28.5 years while the mean ages of patients with benign, borderline and malignant PTs were 41.7, 48.6 and 42.1 years, respectively. Also all types of PTs were large (>Scm). ER showed a strong nuclear staining in the epithelial component of all tumors while ER/3 immunoreactivity was detected in both the epithelial and stromal components ofF A and PT. ER/β (pcomponent were associated with tumor size. p53 expression was significantly associated with both the epithelial and stromal components of malignant PTs (pcomponent (p=0.000). In addition, MIB-1 was also found to be associated with ER and ER/3 in the stromal component (p=0.000). The expression of p53 with tumor size and histological grade in PT may increase the risk for malignancy.

  10. Cluster processing for 16Mb DRAM production

    International Nuclear Information System (INIS)

    Bergendahl, A.; Horak, D.

    1989-01-01

    Multichamber and in-situ technology are used to meet the challenge of manufacturing 16-Mb cost/performance DRAMs. The 16-Mb fabrication process is more complex than earlier 1-Mb and 4-Mb chips. Clustering of sequential process steps effectively compensates for both manufacturing complexity and foreign-material (FM) related defect densities. The development time of clusters combining new processes and equipment in multiple automated steps is nearly as long as the product development cycle. This necessitates codevelopment of manufacturing process cluster with technology integration while addressing the factors influencing FM defect generation, processing turnaround time (TAT), manufacturing costs, yield and array cell and support device designs. The advantages of multichamber and in situ processing have resulted in their application throughout the entire 16-Mb DRAM process as appropriate equipment becomes available

  11. The correlation between MIB-1, AgNOR, and caspase-3 apoptosis with chemoradiotherapy response in cervical cancer

    International Nuclear Information System (INIS)

    Iin Kurnia; Devita Tetriana; Budiningsih Siregar; Irwan Ramli; Andriono; Setiawan Soetopo; Tjahya Kurjana; Maringan DL Tobing; Bethy Suryawathi

    2013-01-01

    Chemoradiotherapy is one of treatments for the locally advanced cervical cancer given by concurrent radiotherapy combined with chemotherapy in the same time. Chemoradiotherapy response is influenced by biological factor i.e. cell kinetic that consists of cell proliferation and death. In this research, the correlation between AgNOR, MIB-1 cell proliferation biomarker and the expression of apoptotic caspase-3 with chemoradiotherapy response of cervical cancer has been studied. Twenty one microscopic tissue samples were taken from cervical cancer biopsies before radiotherapy. The tissue samples were stained with AgNOR, whereas MIB-1 and apoptosis caspase-3 in the tissue samples were detected by immunochemistry technique. After the completion of chemoradiotherapy treatment, the clinical response was observed by pelvic control method. The result of this research show that there is no correlation between AgNOR, MIB-1 value with apoptosis (p>0.05) before chemoradiotherapy. Cell proliferation observed by AgNOR and MIB-1 before chemoradiotherapy indicate no correlation with chemoradiotherapy response, however the apoptotic expression shows positive correlation with chemoradiotherapy response. The index of caspase-3 apoptosis obtained from this research can be used for considering the chemoradiotherapy schedule for the cervical cancer patient. (author)

  12. MIB-1 (KI-67) proliferation index and cyclin-dependent kinase inhibitor p27(Kip1) protein expression in nephroblastoma

    NARCIS (Netherlands)

    M.A.I. Ghanem (Mazen); Th.H. van der Kwast (Theo); M.K. Sudaryo; R.B. Mathoera (Rejiv); M.M. van den Heuvel-Eibrink (Marry); A.A. Al-Doray; R.J.M. Nijman (Rien); G.J. van Steenbrugge (Gert Jan)

    2004-01-01

    textabstractPURPOSE: A number of studies have indicated that the tumor proliferation marker MIB-1 and cell cycle inhibitor p27(Kip1) expression are of prognostic importance in a variety of cancers. The present study was performed to evaluate the prognostic value of these

  13. Quantitative method to determine the regional drinking water odorant regulation goals based on odor sensitivity distribution: illustrated using 2-MIB.

    Science.gov (United States)

    Yu, Jianwei; An, Wei; Cao, Nan; Yang, Min; Gu, Junong; Zhang, Dong; Lu, Ning

    2014-07-01

    Taste and odor (T/O) in drinking water often cause consumer complaints and are thus regulated in many countries. However, people in different regions may exhibit different sensitivities toward T/O. This study proposed a method to determine the regional drinking water odorant regulation goals (ORGs) based on the odor sensitivity distribution of the local population. The distribution of odor sensitivity to 2-methylisoborneol (2-MIB) by the local population in Beijing, China was revealed by using a normal distribution function/model to describe the odor complaint response to a 2-MIB episode in 2005, and a 2-MIB concentration of 12.9 ng/L and FPA (flavor profile analysis) intensity of 2.5 was found to be the critical point to cause odor complaints. Thus the Beijing ORG for 2-MIB was determined to be 12.9 ng/L. Based on the assumption that the local FPA panel can represent the local population in terms of sensitivity to odor, and that the critical FPA intensity causing odor complaints was 2.5, this study tried to determine the ORGs for seven other cities of China by performing FPA tests using an FPA panel from the corresponding city. ORG values between 12.9 and 31.6 ng/L were determined, showing that a unified ORG may not be suitable for drinking water odor regulations. This study presents a novel approach for setting drinking water odor regulations. Copyright © 2014. Published by Elsevier B.V.

  14. Rodzina imigrancka z perspektywy historycznej: doświadczenia polskich pionierów w Winnipeg, 1896-1919

    OpenAIRE

    ALBAŃSKI, ŁUKASZ

    2011-01-01

    This paper focuses on an early Polish family life in Winnipeg. The family often served as a mechanism to reduce a sense of dislocation and to facilitate immigrants' adaptation. The family was also the primary economic unit. The family relations were affected by gender. Both immigrant men and women found themselves reconsidering traditional roles. Somehow immigration tested their family roles in newways. Ewa Jurczyk-Romanowska

  15. The proliferation marker pKi-67 becomes masked to MIB-1 staining after expression of its tandem repeats.

    Science.gov (United States)

    Schmidt, Mirko H H; Broll, Rainer; Bruch, Hans-Peter; Duchrow, Michael

    2002-11-01

    The Ki-67 antigen, pKi-67, is one of the most commonly used markers of proliferating cells. The protein can only be detected in dividing cells (G(1)-, S-, G(2)-, and M-phase) but not in quiescent cells (G(0)). The standard antibody to detect pKi-67 is MIB-1, which detects the so-called 'Ki-67 motif' FKELF in 9 of the protein's 16 tandem repeats. To investigate the function of these repeats we expressed three of them in an inducible gene expression system in HeLa cells. Surprisingly, addition of a nuclear localization sequence led to a complete absence of signal in the nuclei of MIB-1-stained cells. At the same time antibodies directed against different epitopes of pKi-67 did not fail to detect the protein. We conclude that the overexpression of the 'Ki-67 motif', which is present in the repeats, can lead to inability of MIB-1 to detect its antigen as demonstrated in adenocarcinoma tissue samples. Thereafter, in order to prevent the underestimation of Ki-67 proliferation indices in MIB-1-labeled preparations, additional antibodies (for example, MIB-21) should be used. Additionally, we could show in a mammalian two-hybrid assay that recombinant pKi-67 repeats are capable of self-associating with endogenous pKi-67. Speculating that the tandem repeats are intimately involved in its protein-protein interactions, this offers new insights in how access to these repeats is regulated by pKi-67 itself.

  16. Normalization of periodontal tissues in osteopetrotic mib mutant rats, treated with CSF-1

    Science.gov (United States)

    Wojtowicz, A.; Yamauchi, M.; Sotowski, R.; Ostrowski, K.

    1998-01-01

    The osteopetrotic mib mutation in rats causes defects in the skeletal bone tissue in young animals. These defects, i.e. slow bone remodelling, changes in both crystallinity and mineral content, are transient and undergo normalization, even without any treatment in 6-wk-old animals. Treatment with CSF-1 (colony stimulating factor-1) accelerates the normalization process in skeletal bones. The periodontal tissues around the apices of incisors show abnormalities caused by the slow remodelling process of the mandible bone tissue, the deficiency of osteoclasts and their abnormal morphology, as well as the disorganization of periodontal ligament fibres. In contrast to the skeletal tissues, these abnormalities would not undergo spontaneous normalization. Under treatment with colony stimulating factor 1 (CSF-1), the primitive bone trabeculae of mandible are resorbed and the normalization of the number of osteoclasts and their cytology occurs. The organization of the periodontal ligament fibres is partially restored, resembling the histological structure of the normal one.

  17. Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3.

    Science.gov (United States)

    Artico, M; Bronzetti, E; Alicino, V; Ionta, B; Bosco, S; Grande, C; Bruno, M; Tranquilli Leali, F M; Ionta, G; Fumagalli, L

    2010-03-11

    Gallbladder carcinoma is the most common biliary tract tumor and the fifth most common gastrointestinal tract cancer .The prognosis of gallbladder carcinoma is poor and less than 5% of the patients are still alive five years postoperatively. Gallbladder specimens were obtained during surgical operations performed in eleven patients for resection of a gallbladder carcinoma, and during five autopsies (control cases selected among patients who died from for other causes, excluding those suffering from biliary or hepatic diseases). Immunohistochemical characterization and distribution of neurotrophins, with their respective receptors, were analyzed. The actual role played by these neurotrophic factors in the general regulation, vascular permeability, algic responsiveness, release of locally active substances and potential tumorigenesis in the gallbladder and biliary ducts compartment remains controversial. Our study revealed an increased immunohistochemical expression of NGF and TrKA in the epithelium and in the epithelial glands of the gallbladder carcinoma together with an evident immunoreactivity for BDNF in the same neoplastic areas. An evident immunoreactivity for NGF, TrKA and BDNF was observed in control specimens of gallbladder obtained during autopsies, whereas a weak or quite absent immunoreactivity was observed in the same specimens for NT4, TrKC and p75. On the contrary an appreciable immunoreactivity for p75 was observed in the specimens harvested from patients with gallbladder carcinoma. We also investigated the expression of some known tumor markers such as MIB-1 (anti Ki-67), CD34 and CA15-3, to identify a possible correlation between the expression of these molecular factors and the prognosis of gallbladder carcinoma. They resulted highly expressed in the stroma (CD34 and CA 15-3) and in the epithelium/epithelial glands (MIB-1) of the neoplastic areas and appeared to be almost absent in the control cases, suggesting that these markers, taken together

  18. Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3

    Directory of Open Access Journals (Sweden)

    M. Artico

    2010-03-01

    Full Text Available Gallbladder carcinoma is the most common biliary tract tumor and the fifth most common gastrointestinal tract cancer .The prognosis of gallbladder carcinoma is poor and less than 5% of the patients are still alive five years postoperatively.1 Gallbladder specimens were obtained during surgical operations performed in eleven patients for resection of a gallbladder carcinoma, and during five autopsies (control cases selected among patients who died from for other causes, excluding those suffering from biliary or hepatic diseases. Immunohistochemical characterization and distribution of neurotrophins, with their respective receptors, were analyzed. The actual role played by these neurotrophic factors in the general regulation, vascular permeability, algic responsiveness, release of locally active substances and potential tumorigenesis in the gallbladder and biliary ducts compartment remains controversial. Our study revealed an increased immunohistochemical expression of NGF and TrKA in the epithelium and in the epithelial glands of the gallbladder carcinoma together with an evident immunoreactivity for BDNF in the same neoplastic areas. An evident immunoreactivity for NGF, TrKA and BDNF was observed in control specimens of gallbladder obtained during autopsies, whereas a weak or quite absent immunoreactivity was observed in the same specimens for NT4, TrKC and p75. On the contrary an appreciable immunoreactivity for p75 was observed in the specimens harvested from patients with gallbladder carcinoma. We also investigated the expression of some known tumor markers such as MIB-1 (anti Ki-67, CD34 and CA15-3, to identify a possible correlation between the expression of these molecular factors and the prognosis of gallbladder carcinoma. They resulted highly expressed in the stroma (CD34 and CA 15-3 and in the epithelium/epithelial glands (MIB-1 of the neoplastic areas and appeared to be almost absent in the control cases, suggesting that these markers

  19. MIB-1, AgNOR AND DNA DISTRIBUTION PARAMETERS AND THEIR PROGNOSTIC VALUE IN NEUROENDOCRINE TUMOURS OF THE LUNG

    Directory of Open Access Journals (Sweden)

    Uta Jütting

    2011-05-01

    Full Text Available One of the most important questions in clinical routine is to find out patients with good or worse prognosis to apply an optimal therapy scheme for each patient. In this study 58 patients with different neuroendocrine tumours of the lung were investigated. Histological sections were prepared with different stainings (MIB-1, AgNOR, Feulgen. By means of high resolution image cytometry stereological parameters were derived which are indicators for proliferation, ploidy and kinetics of the tumours. Cox regression analysis was calculated to test the significance of the parameters with regard to prognosis. The best parameter was MIB-1 which can easily be applied as a clinical standard staining and measurement.

  20. Nutrient delivery to Lake Winnipeg from the Red-Assiniboine River Basin – A binational application of the SPARROW model

    Science.gov (United States)

    Benoy, Glenn A; Jenkinson, R. Wayne; Robertson, Dale M.; Saad, David A.

    2016-01-01

    Excessive phosphorus (TP) and nitrogen (TN) inputs from the Red–Assiniboine River Basin (RARB) have been linked to eutrophication of Lake Winnipeg; therefore, it is important for the management of water resources to understand where and from what sources these nutrients originate. The RARB straddles the Canada–United States border and includes portions of two provinces and three states. This study represents the first binationally focused application of SPAtially Referenced Regressions on Watershed attributes (SPARROW) models to estimate loads and sources of TP and TN by jurisdiction and basin at multiple spatial scales. Major hurdles overcome to develop these models included: (1) harmonization of geospatial data sets, particularly construction of a contiguous stream network; and (2) use of novel calibration steps to accommodate limitations in spatial variability across the model extent and in the number of calibration sites. Using nutrient inputs for a 2002 base year, a RARB TP SPARROW model was calibrated that included inputs from agriculture, forests and wetlands, wastewater treatment plants (WWTPs) and stream channels, and a TN model was calibrated that included inputs from agriculture, WWTPs and atmospheric deposition. At the RARB outlet, downstream from Winnipeg, Manitoba, the majority of the delivered TP and TN came from the Red River Basin (90%), followed by the Upper Assiniboine River and Souris River basins. Agriculture was the single most important TP and TN source for each major basin, province and state. In general, stream channels (historically deposited nutrients and from bank erosion) were the second most important source of TP. Performance metrics for the RARB SPARROW model are similarly robust compared to other, larger US SPARROW models making it a potentially useful tool to address questions of where nutrients originate and their relative contributions to loads delivered to Lake Winnipeg.

  1. Differential expression of cyclin Dl in human pituitary tumors: relation to MIB-1 and p27/Kipl labeling indices

    International Nuclear Information System (INIS)

    Hewedi, I.H.; Osman, W.M.; El Mahdy, M.M.

    2011-01-01

    Pituitary tumors are a common form of endocrine neoplasia. However few studies assessed the expression of the principal cyclin regulating checkpoint exit, cyclin Dl. Cyclin Dl expression in pituitary tumors and its possible relation to MIB-1 and p27/K.ipl labeling indices (Us) was explored. Design: We studied a total of 199 pituitaries, including normal pituitaries (n = 7), pituitary adenomas (n = 187), and pituitary carcinoma (n = 5). All tissues were tested as cores of archived tissue microarrays that were immuno stained for cyclin Dl, MIB-1 and p27 using a standard technique. Tissue cores were subjected to automated analysis to evaluate the staining LIs, Results: No cyclin Dl positive cells in the normal anterior pituitary gland was found. Sparse nuclear staining was noted in pituitary tumors. Higher expression of cyclin Dl was noted in pituitary carcinomas compared to adenomas (p < 0.001), in non-functioning adenomas compared to functioning ones (p < 0.001) in macroadenomas versus micro adenomas (p — 0.017) and in recurrent non recurrent adenomas (p < 0.001). Cyclin Dl LI and MIB-1 LI were related among adenomas (p < 0.001) and carcinomas (p = 0.041). p27 LI was neither related to pituitary adenoma recurrence nor invasion. Conclusions: Expression of cyclin Dl in pituitary tumors is related to cell proliferation, recurrence, and metastatic potential. Nuclear cyclin Dl expression is a good marker of aggressive behavior in pituitary tumors

  2. Immunohistochemical profile of neurotrophins and MIB-1 in jugulotympanic paragangliomas: prognostic value and review of the literature.

    Science.gov (United States)

    Artico, M; De Vincentiis, M; Ionta, B; Bianchi, E; Bosco, S; Onteleone, M; Fumagalli, L; Magliulo, G

    2012-01-01

    Jugulo-tympanic paragangliomas are the most common primary neoplasm of the middle ear, but little is still known about the histological features differentiating the benign and malignant forms. We investigated, with an immunohistochemical procedure, the expression of neurotrophins with their receptors, in fifteen samples of paragangliomas, and MIB-1 in order to consider them as prognostic factors of malignancy. We observed a general positivity for NGF - TrKA - NT4 - TrKC in the cytoplasm, and a strong expression for BDNF in the extracellular space. MIB-1 was moderate in the nucleus of neoplastic cells, weak in the cytoplasm and totally absent in the extracellular space. The comparison between the clinical recurrences and the rate of cytoplasmatic neurotrophins showed strong immunoreactivity in recurrent patients. It should be emphasized that 2 of the 3 recurrences had a wider distribution of the neutrophins, leading to hypothesize the involvement of these substances in the cell proliferation of glomus tumors. Malignant forms of these rare glomus tumors cannot be clearly identified using MIB-1 as a prognostic marker, although we can affirm that neurotrophins and their receptors can be considered as a panel of potential diagnostic markers to monitor the development of such malignancies. Although the small number of patients does not allow definitive conclusions to be made, our findings showed a possible trend towards significance which requires a more powerful study to evaluate this further.

  3. 10 MB disk platter from CDC 7638

    CERN Multimedia

    1974-01-01

    This magnetic disk was one of three which interfaced with various Control Data machines. This single platter came from a Control Data 7638 Disk Storage Subsystem and could contain up to 10MB - about the size of a few MP4's on your iPod.

  4. MIB Probes for measurements of particle and energy fluxes in plasma of Wendelstein 7-X

    Science.gov (United States)

    Demidov, V. I.; Koepke, M. E.; Kurlyandskaya, I. P.; Raitses, Y.

    2014-10-01

    Magnetically insulated baffled (MIB) probes and probe arrays that share the simplicity of simple Langmuir probes but supersede them in their ability to make real-time measurements of plasma potential, temperature and energy/particle fluxes in W7-X stellarator plasma are being developed. The probes offer the advantages of direct measurements of the plasma fluid observables, while being non-emitting and electrically floating. The principle of operation of the probe is based on the dependence of the voltage drop in the plasma-probe sheath on the direction of the local magnetic field. The core technology for these probes rests with the use of a special baffling configuration such that electron current to the probe is fully controllable in the closed, open or partially open orientation, by a simple rotation of the baffle with respect to the magnetic field alignment in the plasma. The baffled-probe designs proposed for edge diagnostics will increase the capability to characterize separately plasma properties in real-time for understanding of underlying physics in the edge plasma.

  5. Immunohistochemical profile of various neurotransmitters, neurotrophins and MIB-1 in cholesteatomas of the petrous bone.

    Science.gov (United States)

    Artico, Marco; Bronzetti, Elena; Lo Vasco, Vincenza Rita; Ionta, Brunella; Alicino, Valentina; D'Ambrosio, Anna; Magliulo, Giuseppe

    2008-01-01

    Compared to the normal epidermal epithelium, cholesteatomas have altered growth properties characterized by the excessive growth of keratinocytes leading to mucosal destruction. Either congenital or acquired, these lesions, which grow in the middle ear space, the petrous apex or the mastoid of temporal bones, are mostly considered benign skin tumoral lesions. However, many questions remain concerning their pathophysiology. Numerous studies have been proposed to identify those cholesteatoma lesions at risk of recurrence, a possible event that may cause hearing loss. We examined patients with petrous apex or mastoid cholesteatoma in order to analyze the expression of various neurotransmitters, neurotrophins and their receptors and the Ki-67 antigen for identification of a possible relationship between clinical outcome and histopathological behaviour in terms of the proliferative activity of cholesteatomas. Expression of the analyzed molecules was studied using immunohistochemical methods in seven adult patients with petrous apex cholesteatoma who underwent surgical removal of the lesion. Our results, in accordance with published data, confirm that Molecular Immunology Borstel-1 (MIB-1) and certain neurotransmitters could be useful in the prognostic evaluation of the risk of recurrence of aggressive forms of cholesteatoma.

  6. Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index

    International Nuclear Information System (INIS)

    Uehara, Kazuyuki; Fujii, Osamu; Soejima, Toshinori; Sugimura, Kazuro; Kohmura, Eiji; Sasaki, Ryohei; Sasayama, Takashi; Miyawaki, Daisuke; Nishimura, Hideki; Yoshida, Kenji; Okamoto, Yoshiaki; Mukumoto, Naritoshi; Akasaka, Hiroaki; Nishihara, Masamitsu

    2012-01-01

    The purpose of the present study was to analyze the recurrence pattern of high-grade glioma treated with a multimodal treatment approach and to evaluate whether the MIB-1 labeling index (LI) could be a useful marker for predicting the pattern of failure in glioblastoma (GB). We evaluated histologically confirmed 131 patients with either anaplastic astrocytoma (AA) or GB. A median dose was 60 Gy. Concomitant and adjuvant chemotherapy were administered to 111 patients. MIB-1 LI was assessed by immunohistochemistry. Recurrence patterns were categorized according to the areas of recurrence as follows: central failure (recurrence in the 95% of 60 Gy); in-field (recurrence in the high-dose volume of 50 Gy; marginal (recurrence outside the high-dose volume) and distant (recurrence outside the RT field). The median follow-up durations were 13 months for all patients and 19 months for those remaining alive. Among AA patients, the 2-year progression-free and overall survival rates were 23.1% and 39.2%, respectively, while in GB patients, the rates were 13.3% and 27.6%, respectively. The median survival time was 20 months for AA patients and 15 months for GB patients. Among AA patients, recurrences were central in 68.7% of patients; in-field, 18.8%; and distant, 12.5%, while among GB patients, 69.0% of recurrences were central, 15.5% were in-field, 12.1% were marginal, and 3.4% were distant. The MIB-1 LI medians were 18.2% in AA and 29.8% in GB. Interestingly, in patients with GB, the MIB-1 LI had a strong effect on the pattern of failure (P = 0.014), while the extent of surgical removal (P = 0.47) and regimens of chemotherapy (P = 0.57) did not. MIB-1 LI predominantly affected the pattern of failure in GB patients treated with a multimodal approach, and it might be a useful tool for the management of the disease

  7. Dal CERN, flusso si dati a una media di 600 megabytes al secondo per dieci giorni consecutivi

    CERN Multimedia

    2005-01-01

    The supercomputer Grid took up successfully its first technologic challenge. Egiht supercomputing centers have supported on internet a continuous flow of data from CERN in Geneva and directed them to seven centers in Europe and United States

  8. Assessment of whether upstream passage for Lake Sturgeon is needed at the Pointe du Bois Generating Station (Winnipeg River)

    International Nuclear Information System (INIS)

    Pratt, T.

    2010-01-01

    This document reviewed Manitoba Hydro's proposal to modernize the Pointe du Bois Generating Station (GS) on the Winnipeg River, with particular reference to the potential impacts on Lake Sturgeon in Management Unit 5 (MU5) where large numbers of the fish spawn at the base of the falls. The modernization will involve replacing the spillway, dam segments and replacing or repairing the powerhouse. The pros and cons of providing upstream fish passage for Lake Sturgeon and the generating station were outlined. The only spawning area in the MU5 area may be altered considerably due to changes in water flow, depending on the design chosen for modernization. A potential benefit of providing upstream fish passage for Lake Sturgeon would be to increase genetic diversity within the Winnipeg River. Another potential benefit would be to allow Lake Sturgeon, from the relatively dense population below the GS, to move upstream into MU4 where unfilled habitat may be available and Lake Sturgeon abundance is lower. A potential disadvantage of providing fish passage would be the loss of individual Lake Sturgeon from the healthy population in MU5 with no accompanying benefit to MU4. There would be no net gain to MU4 or MU5 if migrating Lake Sturgeon returned to MU5 rather than proceeding upstream. It was concluded that these current gaps in knowledge must be filled in order to fully assess the environmental impacts. 2 figs.

  9. Bcl-2 protein expression is associated with p27 and p53 protein expressions and MIB-1 counts in breast cancer

    International Nuclear Information System (INIS)

    Tsutsui, Shinichi; Yasuda, Kazuhiro; Suzuki, Kosuke; Takeuchi, Hideya; Nishizaki, Takashi; Higashi, Hidefumi; Era, Shoichi

    2006-01-01

    Recent experimental studies have shown that Bcl-2, which has been established as a key player in the control of apoptosis, plays a role in regulating the cell cycle and proliferation. The aim of this study was to investigate the relationship between Bcl-2 and p27 protein expression, p53 protein expression and the proliferation activity as defined by the MIB-1 counts. The prognostic implication of Bcl-2 protein expression in relation to p27 and p53 protein expressions and MIB-1 counts for breast cancer was also evaluated. The immunohistochemical expression of Bcl-2 protein was evaluated in a series of 249 invasive ductal carcinomas of the breast, in which p27 and p53 protein expressions and MIB-1 counts had been determined previously. The Bcl-2 protein expression was found to be decreased in 105 (42%) cases. A decreased Bcl-2 protein expression was significantly correlated with a nuclear grade of III, a negative estrogen receptor, a decreased p27 protein expression, a positive p53 protein expression, positive MIB-1 counts and a positive HER2 protein expression. The incidence of a nuclear grade of III and positive MIB-1 counts increased as the number of abnormal findings of Bcl-2, p27 and p53 protein expressions increased. A univariate analysis indicated a decreased Bcl-2 protein expression to be significantly (p = 0.0089) associated with a worse disease free survival (DFS), while a multivariate analysis indicated the lymph node status and MIB-1 counts to be independently significant prognostic factors for the DFS. The Bcl-2 protein expression has a close correlation with p27 and p53 protein expressions and the proliferation activity determined by MIB-1 counts in invasive ductal carcinoma of the breast. The prognostic value of Bcl-2 as well as p27 and p53 protein expressions was dependent on the proliferation activity in breast cancer

  10. Bcl-2 protein expression is associated with p27 and p53 protein expressions and MIB-1 counts in breast cancer

    Directory of Open Access Journals (Sweden)

    Nishizaki Takashi

    2006-07-01

    Full Text Available Abstract Background Recent experimental studies have shown that Bcl-2, which has been established as a key player in the control of apoptosis, plays a role in regulating the cell cycle and proliferation. The aim of this study was to investigate the relationship between Bcl-2 and p27 protein expression, p53 protein expression and the proliferation activity as defined by the MIB-1 counts. The prognostic implication of Bcl-2 protein expression in relation to p27 and p53 protein expressions and MIB-1 counts for breast cancer was also evaluated. Methods The immunohistochemical expression of Bcl-2 protein was evaluated in a series of 249 invasive ductal carcinomas of the breast, in which p27 and p53 protein expressions and MIB-1 counts had been determined previously. Results The Bcl-2 protein expression was found to be decreased in 105 (42% cases. A decreased Bcl-2 protein expression was significantly correlated with a nuclear grade of III, a negative estrogen receptor, a decreased p27 protein expression, a positive p53 protein expression, positive MIB-1 counts and a positive HER2 protein expression. The incidence of a nuclear grade of III and positive MIB-1 counts increased as the number of abnormal findings of Bcl-2, p27 and p53 protein expressions increased. A univariate analysis indicated a decreased Bcl-2 protein expression to be significantly (p = 0.0089 associated with a worse disease free survival (DFS, while a multivariate analysis indicated the lymph node status and MIB-1 counts to be independently significant prognostic factors for the DFS. Conclusion The Bcl-2 protein expression has a close correlation with p27 and p53 protein expressions and the proliferation activity determined by MIB-1 counts in invasive ductal carcinoma of the breast. The prognostic value of Bcl-2 as well as p27 and p53 protein expressions was dependent on the proliferation activity in breast cancer.

  11. The 1990 MB: The first Mars Trojan

    Science.gov (United States)

    Bowell, Edward

    1991-01-01

    Asteroid 1990 MB was discovered during the course of the Mars and Earth-crossing Asteroid and Comet Survey. An orbit based on a 9-day arc and the asteroid's location near Mars L5 longitude led to speculation that it might be in 1:1 resonance with Mars, analogous to the Trojan asteroids of Jupiter. Subsequent observations strengthened the possibility, and later calculations confirmed it. The most recent orbit shows that the asteroid's semimajor axis is very similar to that of Mars.

  12. Osteoporose bei Mb. Bechterew - neue Ansätze

    OpenAIRE

    Obermayer-Pietsch B; Aglas F; Hermann J; Leb G; Tauber G

    1999-01-01

    Eine axiale Osteoporose und daraus resultierende vertebrale Kompressionsfrakturen sind häufige Symptome eines Mb. Bechterew (MbB, Spondylarthritis ankylosans). Als ein möglicher genetischer Faktor der Osteoporose wurde eine Assoziation der Knochendichte (BMD) mit BsmI- und FokI-Polymorphismen im Vitamin D-Rezeptor-(VDR-)Gen publiziert. In der vorliegenden Studie wurden die Beziehungen zwischen diesen Polymorphismen, Knochenstoffwechsel, BMD und Aktivitätsindizes bei Patienten mit MbB untersuc...

  13. Canada's evacuation policy for pregnant First Nations women: Resignation, resilience, and resistance.

    Science.gov (United States)

    Lawford, Karen M; Giles, Audrey R; Bourgeault, Ivy L

    2018-02-10

    Aboriginal peoples in Canada are comprised of First Nations, Métis, and Inuit. Health care services for First Nations who live on rural and remote reserves are mostly provided by the Government of Canada through the federal department, Health Canada. One Health Canada policy, the evacuation policy, requires all First Nations women living on rural and remote reserves to leave their communities between 36 and 38 weeks gestational age and travel to urban centres to await labour and birth. Although there are a few First Nations communities in Canada that have re-established community birthing and Aboriginal midwifery is growing, most First Nations communities are still reliant on the evacuation policy for labour and birthing services. In one Canadian province, Manitoba, First Nations women are evacuated to The Pas, Thompson, or Winnipeg but most - including all women with high-risk pregnancies - go to Winnipeg. To contribute scholarship that describes First Nations women's and community members' experiences and perspectives of Health Canada's evacuation policy in Manitoba. Applying intersectional theory to data collected through 12 semi-structured interviews with seven women and five community members (four females, one male) in Manitoba who had experienced the evacuation policy. The data were analyzed thematically, which revealed three themes: resignation, resilience, and resistance. The theme of resignation was epitomized by the quote, "Nobody has a choice." The ability to withstand and endure the evacuation policy despite poor or absent communication and loneliness informed of resilience. Resistance was demonstrated by women who questioned the necessity and requirement of evacuation for labour and birth. In one instance, resistance took the form of a planned homebirth with Aboriginal registered midwives. There is a pressing need to improve the maternity care services that First Nations women receive when they are evacuated out of their communities, particularly

  14. Fusion Canada

    International Nuclear Information System (INIS)

    1987-07-01

    This first issue of a quarterly newsletter announces the startup of the Tokamak de Varennes, describes Canada's national fusion program, and outlines the Canadian Fusion Fuels Technology Program. A map gives the location of the eleven principal fusion centres in Canada. (L.L.)

  15. Structure of superhard tungsten tetraboride: A missing link between MB2 and MB12 higher borides

    Science.gov (United States)

    Lech, Andrew T.; Turner, Christopher L.; Mohammadi, Reza; Tolbert, Sarah H.; Kaner, Richard B.

    2015-01-01

    Superhard metals are of interest as possible replacements with enhanced properties over the metal carbides commonly used in cutting, drilling, and wear-resistant tooling. Of the superhard metals, the highest boride of tungsten—often referred to as WB4 and sometimes as W1–xB3—is one of the most promising candidates. The structure of this boride, however, has never been fully resolved, despite the fact that it was discovered in 1961—a fact that severely limits our understanding of its structure–property relationships and has generated increasing controversy in the literature. Here, we present a new crystallographic model of this compound based on refinement against time-of-flight neutron diffraction data. Contrary to previous X-ray–only structural refinements, there is strong evidence for the presence of interstitial arrangements of boron atoms and polyhedral bonding. The formation of these polyhedra—slightly distorted boron cuboctahedra—appears to be dependent upon the defective nature of the tungsten-deficient metal sublattice. This previously unidentified structure type has an intermediary relationship between MB2 and MB12 type boride polymorphs. Manipulation of the fractionally occupied metal and boron sites may provide insight for the rational design of new superhard metals. PMID:25733870

  16. The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer

    DEFF Research Database (Denmark)

    Jensen, V; Ladekarl, M; Holm-Nielsen, P

    1995-01-01

    The prognostic value of oncogenic antigen 519 (OA-519) expression and tumour proliferative activity was evaluated in a retrospective series of 118 patients with low-risk breast cancer. Low risk was defined as negative axillary nodes, tumour diameter histological evidence...... analysis, both the MIB-1 index and OA-519 expression were of independent prognostic value (2p breast cancer who might benefit from adjuvant therapy....

  17. Experimental utilization of the IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Bitelli, U. d'Utra; Santos, A. dos; Jerez, R.; Diniz, R.; Fanaro, L.C.C.B.; Abe, A.Y.; Moreira, J.M.L.; Fer, N.; Giada, M.R.; Fuga, R.

    2003-01-01

    This paper aims to show the experimental utilization of the IPEN/MB-01 nuclear reactor during the last fourteen years. The IPEN/MB-01 is a zero-power critical assembly specially designed to measure integral and differential reactor physics parameters to validate calculational methodologies and related nuclear data libraries. Experiments involving determination of spectral indices, critical mass, relative abundance of delayed neutrons, the inversion point of the isothermal reactivity coefficient and burnable poison are considered the most important experiments. Current experiments at IPEN/MB-01 reactor are also commented. (author)

  18. Osteoporose bei Mb. Bechterew - neue Ansätze

    Directory of Open Access Journals (Sweden)

    Obermayer-Pietsch B

    1999-01-01

    Full Text Available Eine axiale Osteoporose und daraus resultierende vertebrale Kompressionsfrakturen sind häufige Symptome eines Mb. Bechterew (MbB, Spondylarthritis ankylosans. Als ein möglicher genetischer Faktor der Osteoporose wurde eine Assoziation der Knochendichte (BMD mit BsmI- und FokI-Polymorphismen im Vitamin D-Rezeptor-(VDR-Gen publiziert. In der vorliegenden Studie wurden die Beziehungen zwischen diesen Polymorphismen, Knochenstoffwechsel, BMD und Aktivitätsindizes bei Patienten mit MbB untersucht. Bei 47 MbB-Patienten wurden Aktivitätsindizes und morphologische Parameter sowie BMD-Messungen (Dual-Röntgen-Absorptiometrie an Wirbelsäule und Schenkelhals im Vergleich zu 52 gesunden, altersgleichen Personen erhoben. Die Laborbestimmungen umfaßten biochemische Aktivitätsparameter, HLA-Typisierung sowie Knochenan- und -abbaumarker. Aus peripheren Leukozyten wurde genomische DNA präpariert und mittels Polymerase-Kettenreaktion (PCR und anschließender FokI- und BsmI-Restriktion der VDR-Genotyp nach vorhandenen bzw. fehlenden Schnittstellen (f/b bzw. F/B bestimmt. Bei MbB-Patienten fand sich eine Osteoporose deutlich häufiger als in der Kontrollgruppe. Eine Zuordnung von Aktivitätsindizes, BMD und Knochenstoffwechselparametern zu den Genotypen zeigte bei männlichen MbB-Patienten sowohl eine Assoziation der WS-Knochendichte als auch der Entzündungsmarker mit FokI-, nicht jedoch mit BsmI-Genotypen des VDR. Die pathophysiologischen Mechanismen dieser Assoziation, insbesondere mit der entzündlichen Aktivität des Mb. Bechterew, sind noch ungeklärt. Eine frühzeitige Erfassung des Osteoporoserisikos bei MbB-Patienten mittels molekularbiologischer Tests könnte eine rechtzeitige Prophylaxe und Therapie dieser Komplikation ermöglichen.

  19. 'I'm more aware of my HIV risk than anything else': syndemics of syphilis and HIV among gay men in Winnipeg.

    Science.gov (United States)

    Yu, Dorothy; Hatala, Andrew R; Reimer, Joss; Lorway, Rob

    2017-12-22

    Despite decreased rates of HIV infection in Winnipeg, syphilis incidence continues to rise. Communities of men who have sex with men shoulder much of this burden of illness. This qualitative study aimed to better understand the co-evolution of HIV and syphilis in Winnipeg through a series of interviews with gay men. Eighteen individuals were recruited through advertising in sexual health centres and through subsequent snowball sampling. Thematic interpretive analysis and inductive reasoning were used to find individual and shared group meanings. We found that HIV formed the contextual ground on which sexual decision-making was made, with three main themes emerging during interviews: 1) bacterial STI transience being contrasted against HIV permanence; 2) syphilis being 'dirty' versus HIV carrying significant stigma, though being spared the label of uncleanliness; and 3) the role of pleasure and intimacy in sexual health decision-making. Based on these findings, we recommend further exploration to develop more effective strategies around syphilis prevention, in particular with regards to the longer-term illness ramifications and its relationship to HIV transmission.

  20. The use of a policy dialogue to facilitate evidence-informed policy development for improved access to care: the case of the Winnipeg Central Intake Service (WCIS).

    Science.gov (United States)

    Damani, Zaheed; MacKean, Gail; Bohm, Eric; DeMone, Brie; Wright, Brock; Noseworthy, Tom; Holroyd-Leduc, Jayna; Marshall, Deborah A

    2016-10-18

    Policy dialogues are critical for developing responsive, effective, sustainable, evidence-informed policy. Our multidisciplinary team, including researchers, physicians and senior decision-makers, comprehensively evaluated The Winnipeg Central Intake Service, a single-entry model in Winnipeg, Manitoba, to improve patient access to hip/knee replacement surgery. We used the evaluation findings to develop five evidence-informed policy directions to help improve access to scheduled clinical services across Manitoba. Using guiding principles of public participation processes, we hosted a policy roundtable meeting to engage stakeholders and use their input to refine the policy directions. Here, we report on the use and input of a policy roundtable meeting and its role in contributing to the development of evidence-informed policy. Our evidence-informed policy directions focused on formal measurement/monitoring of quality, central intake as a preferred model for service delivery, provincial scope, transparent processes/performance indicators, and patient choice of provider. We held a policy roundtable meeting and used outcomes of facilitated discussions to refine these directions. Individuals from our team and six stakeholder groups across Manitoba participated (n = 44), including patients, family physicians, orthopaedic surgeons, surgical office assistants, Winnipeg Central Intake team, and administrators/managers. We developed evaluation forms to assess the meeting process, and collected decision-maker partners' perspectives on the value of the policy roundtable meeting and use of policy directions to improve access to scheduled clinical services after the meeting, and again 15 months later. We analyzed roundtable and evaluation data using thematic analysis to identify key themes. Four key findings emerged. First, participants supported all policy directions, with revisions and key implementation considerations identified. Second, participants felt the policy roundtable

  1. Reactor IPEN/MB-01 dosimetry using TLDs

    Energy Technology Data Exchange (ETDEWEB)

    Cavalieri, Tássio A.; Siqueira, Paulo T.D.; Yoriyaz, Hélio, E-mail: tassio.cavalieri@usp.br [Instituto de Pesquisas Energética s e Nucleares (IPEN/CNEN-SP), São Paulo, SP (Brazil)

    2017-07-01

    This paper is a preliminary study on the use of reactor IPEN/MB-01 as standard radiation source for mixed field dosimetry studies. As a first step on this attempt, simulations and experiments, evaluating the neutron and gamma field distributions, were performed and compared. TLDs are widely employed in dose measurements and the TLD 100 / TLD 700 pair conforms with ICRU recommendations for mixed field dosimetry. In this study, TLD irradiations were performed in the IPEN/MB-01 nuclear reactor. IPEN/MB-01 reactor is zero power reactor widely used to perform reactor physics experiments. Its neutron flux distribution is well known for a variety of reactor core configurations. However, the photon fluxes are unknown. A series of experiments with TLD 100 and TLD 700 were performed for two different core configurations (rectangular and cylindrical with a central flux trap). Simulations with MCNP5 for these two configurations were also done, and neutron and gamma fluxes distributions along the core were computed. The responses of TLD 100 and TLD 700 were compared with simulated fluxes and showing a good agreement between them. This paper presents the results of the experiments done so far given the status of the study under way in order to couple IPEN/MB-01 and TLD 100 / 700 pair into a mixed field calibration methodology. (author)

  2. MDT-MB therapy in paucibacillary leprosy: A clinicopathological assessment

    Directory of Open Access Journals (Sweden)

    Prasad P

    2005-01-01

    Full Text Available BACKGROUND: The World Health Organization recommends treatment regimens for paucibacillary (PB and multibacillary (MB leprosy, which differ in their duration and components. Hence accurate classification of the disease is required. To overcome difficulties in classification Uniform Multi Drug Therapy (U-MDT has been recommended. AIM : To evaluate the benefit of adding clofazimine to paucibacillary regimens in leprosy patients by measuring clinical and histological resolution. METHODS: Forty-four paucibacillary patients were included in the study. Twenty-two patients were given MDT-PB regimen and the remaining MDT-MB regimen for six months . Skin biopsies were done before the commencement and at the end of treatment. Clinical and histological resolutions were measured according to the standard criteria a laid down. The results were analyzed using Fishers′ test and Crammers′ V test. RESULTS: Clinical improvement was observed in 90.9% in the MB group as compared to 27.3% in the PB group. Regression in the nerve swelling was observed in 70% in the MB group and in 37.5% in the PB group while histological resolution was observed in 72.8% and 54.5% respectively. CONCLUSIONS: Addition of clofazimine helps to resolve leprosy lesions both clinically and histologically, thus justifying the concept of Uniform MDT regimen for all patients.

  3. Mirrlees MB430 has 23 bar bmep potential

    Energy Technology Data Exchange (ETDEWEB)

    1985-04-01

    Nominally rates at 1000 bhp per cylinder, the new Mirrlees Blackstone MB430 diesel engine with 430 mm bore and 480 mm stroke runs at 600 rev/min under bmep of 21 bar. Initially the engine has been released at 19 bar with the prospect of uprating to 23 bar bmep in due course. The performance testing of the engine is discussed.

  4. A Bibliometric Analysis of Digestive Health Research in Canada

    Directory of Open Access Journals (Sweden)

    Désirée Tuitt

    2011-01-01

    Full Text Available Measurement of the impact and influence of medical/scientific journals, and of individual researchers has become more widely practiced in recent decades. This is driven, in part, by the increased availability of data regarding citations of research articles, and by increased competition for research funding. Digestive disease research has been identified as a particularly strong discipline in Canada. The authors collected quantitative data on the impact and influence of Canadian digestive health research. The present study involved an analysis of the research impact (Hirsch factor and research influence (Influence factor of 106 digestive health researchers in Canada. Rankings of the top 25 researchers on the basis of the two metrics were dominated by the larger research groups at the University of Toronto (Toronto, Ontario, McMaster University (Hamilton, Ontario, and the Universities of Calgary (Calgary, Alberta and Alberta (Edmonton, Alberta, but with representation by other research groups at the Universities of Manitoba (Winnipeg, Manitoba, Western Ontario (London, Ontario and McGill University (Montreal, Quebec. Female and male researchers had similar scores for the two metrics, as did basic scientists versus clinical investigators. Strategic recruitment, particularly of established investigators, can have a major impact on the ranking of research groups. Comparing these metrics over different time frames can provide insights into the vulnerabilities and strengths of research groups.

  5. Green building challenge 2002 in Canada : an overview

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-02-01

    The Green Building Challenge (GBC) in Canada was launched to help the building community meet environmental challenges and improve the environmental performance of buildings. Tools have been made available to the building industry to make informed environmental choices during the conception design stage of a project. The tools help architects, researchers and policy analysts in choosing material mixes and other design options that will minimize a building's potential life cycle environmental impacts and promote sustainable development. Green buildings involve the complete structure and envelope, including cladding, insulation, gypsum wall board, roofing and windows. The type of building and its location is also considered. Long term sustainability also considers energy use and emissions related to a building's energy system. This presentation described the following 3 projects which were selected for assessment in the GBC-2002: (1) the Mayo School in Mayo, Yukon Territory, (2) the Jackson-Triggs Winery in Niagara-on-the-Lake, Ontario, and (3) the Red River College in Winnipeg, Manitoba. The GBC-2002 Canadian Team nominated them as the best buildings being designed in Canada.10 figs.

  6. Glycoprotein CD44 expression in normal, hyperplasic and neoplastic endometrium. An immunohistochemical study including correlations with p53, steroid receptor status and proliferative indices (PCNA, MIB1).

    Science.gov (United States)

    Zagorianakou, N; Ioachim, E; Mitselou, A; Kitsou, E; Zagorianakou, P; Stefanaki, S; Makrydimas, G; Agnantis, N J

    2003-01-01

    We have studied by immunohistochemistry the presence and localization of CD44, estrogen and progesterone receptors, p53 and proliferative associated indices (MIB1, PCNA) in archival endometrial tissue, in order to determine their diagnostic and prognostic value as well as the possible correlations between them. We examined 186 samples of endometrial tissue (100 endometrial carcinomas of endometrioid type, 40 cases of hyperplasia and 46 of normal endometrium). Patient records were examined for FIGO stage, grade, and depth of myometrial invasion, histology, and lympho-vascular space invasion. Strong membranous immunostaining (> 10% of neoplastic cells) was observed in 45% of the carcinomas. A statistically significant correlation was found in the expression of protein in stromal cells, when compared with epithelial cells (p failed to show any statistical correlation with tumor grade or with vessel invasion. The expression of the protein was lower in FIGO Stage II compared with Stage I (p = 0.03). A positive relation of CD44 expression with progesterone receptor status (p = 0.02) was detected. CD44 expression was also positively associated with the proliferation associated with the proliferative index MIB1 (p = 0.001). CD44 is closely related to the secretory phase of the normal menstrual cycle and its expression is decreased in hyperplasia (simple or complex with or without atypia) and in cancer cases. These observations suggest that decreased CD44 expression might be functionally involved in the multiple mechanisms of the development and progression of endometrial lesions.

  7. Health Care and Aboriginal Seniors in Urban Canada: Helping a Neglected Class

    Directory of Open Access Journals (Sweden)

    Loleen Berdahl

    2011-05-01

    Full Text Available Canadian researchers and policymakers have paid limited attention to the health care needs of Aboriginal seniors. This lack of attention is problematic, as the situation of Aboriginal seniors – including both status and non-status First Nations, Métis and Inuit – is particularly bleak. Using Winnipeg, Regina and Saskatoon as examples, this paper analyses the health care challenges facing Aboriginal seniors in urban Canada. We ask, what policy approaches are needed to improve the health and wellbeing of urban Aboriginal seniors so that they can have good quality living reflective of their needs and culture? We suggest that, in thinking throughpresent and future health services for urban Aboriginal seniors, policymakers should consider four key factors: socioeconomic conditions; underutilization of urban health services; jurisdiction; and elder abuse.

  8. Different expression of MIB1 in primary site of non-Hodgkin lymphoma and its bone marrow deposits, a pilot study

    Directory of Open Access Journals (Sweden)

    Malysz J

    2017-02-01

    Full Text Available Jozef Malysz,1 Juanita J Evans,2 Malcolm Acon-Laws,3 Michael G Bayerl,1 Michael H Creer1 1Department of Pathology, Penn State Milton S Hershey Medical Center, Hershey, PA, 2Department of Pathology, St. John Heath – Providence, Southfield, MI, USA; 3Laboratorio de Patologia Hospital Cima, San Jose, Costa Rica Abstract: Evaluation of mindbomb E3 ubiquitin protein ligase 1 (MIB1 (Ki67 proliferation index (PI in B-cell non-Hodgkin lymphomas is increasingly a common addition to classification of lymphoma and staging procedures. Clinicians relay on PI as a surrogate marker of biologic activity; however, no established guidelines have been published whether PI at the primary site of the tumor gives the same answer as evaluation of tumor in staging marrow. In our study, dual immunohistochemical staining for MIB1 and CD20 was performed on tissue from primary site and bone marrow involved by B-cell non-Hodgkin lymphoma to compare PI for each individual patient. For all patients, MIB1 expression was higher at primary tumor site as compared to staging marrow. Additional analysis was performed to investigate the degree of difference depending on lymphoma morphology. Patients with large cell lymphoma at the primary site and large cell morphology in the marrow (LCL-L, those with large cell morphology at the primary site and small cell morphology in the marrow (LCL-S, and those with small cell morphology at the primary site and small cells in the marrow (SCL-S were compared. As expected, LCL cases had a higher mean PI at the primary site when compared to SCL cases (28.5% vs 2.8%, P=0.0001. In addition, the most significant difference between medullary and extramedullary PI was observed in cases with discordant morphology (LCL-S (21% vs 1.1%, P=0.009. Our results indicate that PI of lymphoma within the bone marrow should not be used as a surrogate prognostic indicator of lymphoma biology in its primary site. Keywords: proliferation index, biologic behavior

  9. Sex differences in the MB49 syngeneic, murine model of bladder cancer.

    Science.gov (United States)

    White-Gilbertson, Shai; Davis, Megan; Voelkel-Johnson, Christina; Kasman, Laura M

    The MB49 syngeneic, murine model of bladder cancer has been widely used for more than 35 years. In humans, bladder cancer is one third as prevalent in women as in men, with a trend toward lower prevalence in parous compared to nulliparous women. Our objective was to determine if the MB49 bladder cancer model reproduces the sex differences observed in humans, and to determine its sensitivity to testosterone and the pregnancy hormone, human chorionic gonadotropin (hCG). Male and female C57BL/6 mice were implanted with MB49 murine bladder cancer cells, and observed for tumor growth. MB49 dose responses to hCG and dihydrotestosterone were determined in vitro . MB49 tumor growth was significantly greater in male mice than female mice. Pregnancy did not affect MB49 tumor growth in female mice. MB49 cells did not proliferate in response to hCG in vitro and the functional receptor for gonadotropins was absent. Dihydrotestosterone strongly stimulated growth of MB49 cells in vitro . The MB49 murine model of bladder cancer reproduced some aspects of the sex differences observed in humans. Our results suggest that testosterone may stimulate MB49 cell proliferation, which may explain the more rapid MB49 tumor growth observed in male mice.

  10. ASA24-Canada

    Science.gov (United States)

    A Canadian adaptation of the Automated Self-Administered 24-hour Dietary Assessment Tool (ASA24-Canada), developed by the Food Directorate at Health Canada in collaboration with NCI, has been freely available since April 2014.

  11. Clonal Clusters and Virulence Factors of Group C and G Streptococcus Causing Severe Infections, Manitoba, Canada, 2012-2014.

    Science.gov (United States)

    Lother, Sylvain A; Demczuk, Walter; Martin, Irene; Mulvey, Michael; Dufault, Brenden; Lagacé-Wiens, Philippe; Keynan, Yoav

    2017-07-01

    The incidence of group C and G Streptococcus (GCGS) bacteremia, which is associated with severe disease and death, is increasing. We characterized clinical features, outcomes, and genetic determinants of GCGS bacteremia for 89 patients in Winnipeg, Manitoba, Canada, who had GCGS bacteremia during 2012-2014. Of the 89 patients, 51% had bacteremia from skin and soft tissue, 70% had severe disease features, and 20% died. Whole-genome sequencing analysis was performed on isolates derived from 89 blood samples and 33 respiratory sample controls: 5 closely related genetic lineages were identified as being more likely to cause invasive disease than non-clade isolates (83% vs. 57%, p = 0.002). Virulence factors cbp, fbp, speG, sicG, gfbA, and bca clustered clonally into these clades. A clonal distribution of virulence factors may account for severe and fatal cases of bacteremia caused by invasive GCGS.

  12. Fusion Canada issue 21

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-08-01

    A short bulletin from the National Fusion Program highlighting in this issue Europe proposes Canada`s participation in ITER, tritium for JET, CCFM/TdeV-Tokamak helium pumping and TdeV update, ITER-related R and D at CFFTP, ITER Deputy Director visits Canada, NFP Director to Chair IFRC, Award for Akira Hirose. 3 figs.

  13. The Prognostic Value of International Prognostic Index and MIB-l Immunostaining of Peripheral Lymphoid Tissues and Bone Marrow in Patients with High-Grade Non-Hodgkin's Lymphoma

    International Nuclear Information System (INIS)

    Assem, M.M.

    2001-01-01

    Cell kinetic data are important indicator of the aggressiveness of tumour and clinical response. The Ki-67 antigen plays a pivotal role in maintaining cell proliferation and the expression of this antigen was found to be a valuable indicator for aggressive disease in a variety of neoplastic disorders. Aim of the study: This study aimed to assess the prognostic significance of the expression of Ki-67 antigen in peripheral lymphoid tissues and bone marrow, using the monoclonal antibody MIB-l that is applicable in formaline-fixed paraffin embedded samples in cases with high-grade non-Hodgkin's lymphomas. Material and methods: The MIB-I immunostaining was performed on 96 samples from 48 patients with high-grade non-Hodgkin's lymphomas. The study was performed on tissue sections, nodal or extra nodal, as well as on BM smears or BM paraffin embedded sections of same patients. Ki-67 index was determined using image analyzer. Results: Forty-five out of the studied 48 cases (93.8%) were positive with a median labelling index of 20.425% (Range, 0-58%). We were able to detect bone marrow involvement by detecting MIB-l positive cells in BM samples of 29 patients who were not morphologically diagnosed to have BM infiltration. There was a strong correlation between BM positivity for Ki-67 and Ki-67 labelling index (p < 0.001). Twenty-eight (58.3%) out of the studied 48 cases achieved complete remission (CR). The median duration of CR was 35 months (range, 8-42 months) and the overall survival at 48 months was 35.4% (median 22 months, 95% CI, 13-31 months). The median Ki-67 index (20.425%) was chosen as a cut-off level for statistical analysis of the variables that influence clinical outcome. The probability of inducing CR was associated with low and low intermediate International Prognostic Index (IPI) whereas a low growth fraction was associated, although not significant, with a trend toward a higher probability of inducing a CR. In univariate analysis, high MIB1 labelling

  14. Wave-current induced erosion of cohesive riverbanks in northern Manitoba, Canada

    Science.gov (United States)

    Kimiaghalam, N.; Clark, S.; Ahmari, H.; Hunt, J.

    2015-03-01

    The field of cohesive soil erosion is still not fully understood, in large part due to the many soil parameters that affect cohesive soil erodibility. This study is focused on two channels, 2-Mile and 8-Mile channels in northern Manitoba, Canada, that were built to connect Lake Winnipeg with Playgreen Lake and Playgreen Lake with Kiskikittogisu Lake, respectively. The banks of the channels consist of clay rich soils and alluvial deposits of layered clay, silts and sands. The study of erosion at the sites is further complicated because the flow-induced erosion is combined with the effects of significant wave action due to the large fetch length on the adjacent lakes, particularly Lake Winnipeg that is the seventh largest lake in North America. The study included three main components: field measurements, laboratory experiments and numerical modelling. Field measurements consisted of soil sampling from the banks and bed of the channels, current measurements and water sampling. Grab soil samples were used to measure the essential physical and electrochemical properties of the riverbanks, and standard ASTM Shelby tube samples were used to estimate the critical shear stress and erodibility of the soil samples using an erosion measurement device (EMD). Water samples were taken to estimate the sediment concentration profile and also to monitor changes in sediment concentration along the channels over time. An Acoustic Doppler Current Profiler (ADCP) was used to collect bathymetry and current data, and two water level gauges have been installed to record water levels at the entrance and outlet of the channels. The MIKE 21 NSW model was used to simulate waves using historical winds and measured bathymetry of the channels and lakes. Finally, results from the wave numerical model, laboratory tests and current measurement were used to estimate the effect of each component on erodibility of the cohesive banks.

  15. Wave-current induced erosion of cohesive riverbanks in northern Manitoba, Canada

    Directory of Open Access Journals (Sweden)

    N. Kimiaghalam

    2015-03-01

    Full Text Available The field of cohesive soil erosion is still not fully understood, in large part due to the many soil parameters that affect cohesive soil erodibility. This study is focused on two channels, 2-Mile and 8-Mile channels in northern Manitoba, Canada, that were built to connect Lake Winnipeg with Playgreen Lake and Playgreen Lake with Kiskikittogisu Lake, respectively. The banks of the channels consist of clay rich soils and alluvial deposits of layered clay, silts and sands. The study of erosion at the sites is further complicated because the flow-induced erosion is combined with the effects of significant wave action due to the large fetch length on the adjacent lakes, particularly Lake Winnipeg that is the seventh largest lake in North America. The study included three main components: field measurements, laboratory experiments and numerical modelling. Field measurements consisted of soil sampling from the banks and bed of the channels, current measurements and water sampling. Grab soil samples were used to measure the essential physical and electrochemical properties of the riverbanks, and standard ASTM Shelby tube samples were used to estimate the critical shear stress and erodibility of the soil samples using an erosion measurement device (EMD. Water samples were taken to estimate the sediment concentration profile and also to monitor changes in sediment concentration along the channels over time. An Acoustic Doppler Current Profiler (ADCP was used to collect bathymetry and current data, and two water level gauges have been installed to record water levels at the entrance and outlet of the channels. The MIKE 21 NSW model was used to simulate waves using historical winds and measured bathymetry of the channels and lakes. Finally, results from the wave numerical model, laboratory tests and current measurement were used to estimate the effect of each component on erodibility of the cohesive banks.

  16. Correlation Among Six Biologic Factors (p53, p21WAF1, MIB-1, EGFR, HER2, and Bcl-2) and Clinical Outcomes After Curative Chemoradiation Therapy in Squamous Cell Cervical Cancer

    International Nuclear Information System (INIS)

    Yamashita, Hideomi; Murakami, Naoya; Asari, Takao; Okuma, Kae; Ohtomo, Kuni; Nakagawa, Keiichi

    2009-01-01

    Purpose: The expressions of six cell-cycle-associated proteins were analyzed in cervical squamous cell carcinomas in correlation in a search for prognostic correlations in tumors treated with concurrent chemoradiation therapy (cCRT). Methods and Materials: The expressions of p53, p21/waf1/cip1, molecular immunology borstel-1 (MIB-1), epidermal growth factor receptor (EGFR), human epidermal growth factor receptor type 2 (HER2), and Bcl-2 were studied using an immunohistochemical method in 57 cases of cervical squamous cell carcinoma treated with cCRT. Patients received cCRT between 1998 and 2005. The mean patient age was 61 years (range, 27-82 years). The number of patients with Stage II, III, and IVA disease was 18, 29, and 10, respectively. Results: The number of patients with tumors positive for p53, p21/waf1/cip1, MIB-1, EGFR, HER2, and Bcl-2 was 26, 24, 49, 26, 13, and 11, respectively; no significant correlation was noted. The 5-year overall survival rates of HER2-positive and -negative patients was 76% vs. 44%, which was of borderline significance (p = 0.0675). No significant correlation was noted between overall survival and expressions of p53, p21/waf1/cip1, MIB-1, EGFR, and Bcl-2. No correlation was observed between local control and expression of any of the proteins. Conclusion: Expression of HER2 protein had a weak impact of borderline significance on overall survival in squamous cell carcinoma of the uterine cervix treated with cCRT. However, no clinical associations could be established for p53, p21/waf1/cip1, MIB-1, EGFR, and Bcl-2 protein expressions.

  17. Heavy reflector experiments in the IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Santos, Adimir dos; Silva, Graciete Simoes de Andrade e; Mura, Luis Felipe; Fuga, Rinaldo; Jerez, Rogerio; Mendonca, Arlindo Gilson

    2012-01-01

    Full text: The heavy reflector experiments performed in the IPEN/MB-01 research reactor facility comprise a set of critical configurations employing the standard 28x26-fuel-rod configuration. The heavy reflector either Stainless Steel, Carbon Steel or Nickel plates was placed at one of the faces of the IPEN/MB-01 reactor. Criticality is achieved by inserting the control banks BC1 and BC2 to the critical position. 32 plates around 0.3 mm thick were used in the experiment. The chosen distance between last fuel rod row and the first laminate for both type of laminates was 5.5 mm. Considering initially the SS case, the experimental data reveal that the reactivity decreases up to the sixth plate and after that it increases, becomes nearly zero (which was equivalent to initial zero excess reactivity with zero plates) for the 21 plates case and reaches a value of 154.91 pcm when the whole set of 32 plates are inserted in the reflector. This is a very striking result because it demonstrates that when all 32 plates are inserted in the reflector there is a net gain of reactivity. The reactivity behavior demonstrates all the physics events already mentioned in this work. When the number of plates are small (around 6), the neutron absorption in the plates is more important than the neutron reflection and the reactivity decreases. This condition holds up to a point where the neutron reflection becomes more important than the neutron absorption in the plates and the reactivity increases. The experimental data for the Carbon Steel and Nickel case shows the main features of the SS case, but for the Carbon Steel case the reactivity gain is small, thus demonstrating that Carbon Steel or essentially iron has not the reflector capability as the SS laminates do. The measured data of Nickel plates show a higher reactivity gain, thus demonstrating that Nickel is a good reflector. The theoretical analysis employing MCNP5 and ENDF/B-VII.0 show that the SS calculated results are in a good

  18. Engineering of RuMb: Toward a Green Catalyst for Carbene Insertion Reactions.

    Science.gov (United States)

    Wolf, Matthew W; Vargas, David A; Lehnert, Nicolai

    2017-05-15

    The small, stable heme protein myoglobin (Mb) was modified through cofactor substitution and mutagenesis to develop a new catalyst for carbene transfer reactions. The native heme was removed from wild-type Mb and several Mb His64 mutants (H64D, H64A, H64V), and the resulting apoproteins were reconstituted with ruthenium mesoporphyrin IX (RuMpIX). The reconstituted proteins (RuMb) were characterized by UV-vis and circular dichroism spectroscopy and were used as catalysts for the N-H insertion of aniline derivatives and the cyclopropanation of styrene derivatives. The best catalysts for each reaction were able to achieve turnover numbers (TON) up to 520 for the N-H insertion of aniline, and 350 TON for the cyclopropanation of vinyl anisole. Our results show that RuMb is an effective catalyst for N-H insertion, with the potential to further increase the activity and stereoselectivity of the catalyst in future studies. Compared to native Mb ("FeMb"), RuMb is a more active catalyst for carbene transfer reactions, which leads to both heme and protein modification and degradation and, hence, to an overall much-reduced lifetime of the catalyst. This leads to lower TONs for RuMb compared to the iron-containing analogues. Strategies to overcome this limitation are discussed. Finally, comparison is also made to FeH64DMb and FeH64AMb, which have not been previously investigated for carbene transfer reactions.

  19. Canada's Fusion Program

    International Nuclear Information System (INIS)

    Jackson, D. P.

    1990-01-01

    Canada's fusion strategy is based on developing specialized technologies in well-defined areas and supplying these technologies to international fusion projects. Two areas are specially emphasized in Canada: engineered fusion system technologies, and specific magnetic confinement and materials studies. The Canadian Fusion Fuels Technology Project focuses on the first of these areas. It tritium and fusion reactor fuel systems, remote maintenance and related safety studies. In the second area, the Centre Canadian de fusion magnetique operates the Tokamak de Varennes, the main magnetic fusion device in Canada. Both projects are partnerships linking the Government of Canada, represented by Atomic Energy of Canada Limited, and provincial governments, electrical utilities, universities and industry. Canada's program has extensive international links, through which it collaborates with the major world fusion programs, including participation in the International Thermonuclear Experimental Reactor project

  20. Fusion Canada issue 13

    International Nuclear Information System (INIS)

    1991-01-01

    A short bulletin from the National Fusion Program. Included in this issue is a report on Canada's plans to participate in the Engineering Design Activities (EDA), bilateral meetings with Canada and the U.S., committee meeting with Canada-Europe, an update at Tokamak de Varennes on Plasma Biasing experiments and boronized graphite tests, fusion materials research at the University of Toronto using a dual beam accelerator and a review of the CFFTP and the CCFM. 2 figs

  1. Gas Phase Structure of Amino Acids: La-Mb Studies

    Science.gov (United States)

    Mata, I. Pena S.; Sanz, M. E.; Vaquero, V.; Cabezas, C.; Perez, C.; Blanco, S.; López, J. C.; Alonso, J. L.

    2009-06-01

    Recent improvements in our laser ablation molecular beam Fourier transform microwave (LA-MB-FTMW) spectrometer such as using Laval-type nozzles and picoseconds Nd:YAG lasers (30 to 150 ps) have allowed a major step forward in the capabilities of this experimental technique as demonstrated by the last results in serine cysteine and threonine^a for which seven, six and seven conformers have been respectively identified. Taking advantage of these improvements we have investigated the natural amino acids metionine, aspartic and glutamic acids and the γ-aminobutyric acid (GABA) with the aim of identify and characterize their lower energy conformers. Searches in the rotational spectra have lead to the identification of seven conformers of metionine, six and five of aspartic and glutamic acids, respectively, and seven for the γ-aminobutyric. These conformers have been unambiguously identified by their spectroscopic constants. In particular the ^{14}N nuclear quadrupole coupling constants, that depend heavily on the orientation of the amino group with respect to the principal inertial axes of the molecule, prove to be a unique tool to distinguish unambigously between conformations with similar rotational constants. For the γ-aminobutyric acid two of the seven observed structures are stablized by an intramolecular interaction n-π*. Two new conformers of proline have been identified together with the two previously observed. J. L. Alonso, C. Pérez, M. E. Sanz, J. C. López, S. Blanco, Phys.Chem.Chem.Phys., 2009, 11, 617. D. B. Atkinson, M. A. Smith, Rev. Sci. Instrum. 1995, 66, 4434 S. Blanco, M. E. Sanz, J. C. López, J. L. Alonso, Proc. Natl. Acad. Sci. USA2007, 104, 20183. M. E. Sanz, S. Blanco, J. C. López, J. L. Alonso, Angew. Chem. Int. Ed.,2008, 120, 6312. A. Lesarri, S. Mata, E. J. Cocinero, S. Blanco, J.C. López, J. L. Alonso, Angew. Chem. Int. Ed. , 2002, 41, 4673

  2. Two-site immunoradiometric assay for the MB isoenzyme of creatine kinase

    Energy Technology Data Exchange (ETDEWEB)

    Willson, V J.C.; Jones, H M; Thompson, R J [Cambridge Univ. (UK). Clinical School

    1981-06-18

    A two-site immunoradiometric assay for myocardial creatine kinase MB isoenzyme is described. The method utilizes immobilized anti-human creatine kinase BB antibodies and /sup 125/I-labelled anti-human creatine kinase MM antibodies and can specifically detect creatine kinase MB in the presence of approximately 1000-fold excess of creatine kinase MM or BB. Native kinase MB prepared from human heart and creatine kinase MB prepared by hybridisation of purified human creatine kinase MM and creatine kinase BB appeared to react identically in the assay. Serum estimations on patients with suspected myocardial infarction correlated with the presence of MB band on electrophoresis but preliminary results suggest that the two-site immunoradiometric assay may be more sensitive.

  3. A two-site immunoradiometric assay for the MB isoenzyme of creatine kinase

    International Nuclear Information System (INIS)

    Willson, V.J.C.; Jones, H.M.; Thompson, R.J.

    1981-01-01

    A two-site immunoradiometric assay for myocardial creatine kinase MB isoenzyme is described. The method utilizes immobilized anti-human creatine kinase BB antibodies and 125 I-labelled anti-human creatine kinase MM antibodies and can specifically detect creatine kinase MB in the presence of approximately 1000-fold excess of creatine kinase MM or BB. Native kinase MB prepared from human heart and creatine kinase MB prepared by hybridisation of purified human creatine kinase MM and creatine kinase BB appeared to react identically in the assay. Serum estimations on patients with suspected myocardial infarction correlated with the presence of MB band on electrophoresis but preliminary results suggest that the two-site immunoradiometric assay may be more sensitive. (Auth.)

  4. Fusion Canada issue 8

    International Nuclear Information System (INIS)

    1989-08-01

    A short bulletin from the National Fusion Program. Included in this issue are Canada-ITER contributions, NET Fuel Processing Loop, Bilateral Meeting for Canada-Europe, report from Tokamak de Varennes and a report from the University of Toronto on materials research for Fusion Reactors. 3 figs

  5. Fusion Canada issue 8

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-08-01

    A short bulletin from the National Fusion Program. Included in this issue are Canada-ITER contributions, NET Fuel Processing Loop, Bilateral Meeting for Canada-Europe, report from Tokamak de Varennes and a report from the University of Toronto on materials research for Fusion Reactors. 3 figs.

  6. Fusion Canada issue 21

    International Nuclear Information System (INIS)

    1993-08-01

    A short bulletin from the National Fusion Program highlighting in this issue Europe proposes Canada's participation in ITER, tritium for JET, CCFM/TdeV-Tokamak helium pumping and TdeV update, ITER-related R and D at CFFTP, ITER Deputy Director visits Canada, NFP Director to Chair IFRC, Award for Akira Hirose. 3 figs

  7. Fusion Canada issue 14

    International Nuclear Information System (INIS)

    1991-05-01

    A short bulletin from the National Fusion Program. Included in this issue is a report on a fusion cooperation agreement between Japan and Canada, an update at Tokamak de Varennes on plasma biasing experiments and boronization tests and a collaboration between Canada and the U.S. on a compact toroid fuelling gun. 4 figs

  8. Preliminary decommissioning plan of the reactor IPEN-MB01

    International Nuclear Information System (INIS)

    Vivas, Ary de Souza

    2014-01-01

    Around the world, many nuclear plants were built and need to be turned off at a certain time because they are close to their recommended time of use is approximately 50 years. So the IAEA (International Atomic Energy Agency), seeks to guide and recommend a set of guidelines for the conduct of activities of nuclear facilities, with special attention to countries that do not have a framework regulatory Legal that sustain the activities of decommissioning. Brazil, so far, does not have a specific standard to guide the steps of the guidelines regarding decommissioning research reactors. However, in March 2011 a study committee was formed with the main task facing the issues of decommissioning of nuclear installations in Brazil, culminating in Resolution 133 of November 8, 2012, a standard project that treat about the Decommissioning of nucleoelectric plants. O Instituto de Pesquisas Energeticas e Nucleares (IPEN) has two research reactors one being the reactor IPEN/MB-01. The purpose of this master dissertation is to develop a preliminary plan for decommissioning this research reactor, considering the technical documentation of the facility (RAS-Safety Analysis Report), the existing standards of CNEN (National Nuclear Energy Commission), as well as IAEA recommendations. In terms of procedures for decommissioning research reactors, this work was based on what is most modern in experiences, strategies and lessons learned performed and documented in IAEA publications covering techniques and technologies for decommissioning. Considering these technical knowledge and due to the peculiarities of the facility, was selected to immediate dismantling strategy, which corresponds to the start of decommissioning activities once the installation is switched off, dividing it into work sectors. As a resource for monitoring and project management of reactor decommissioning and maintenance of records, we developed a database using Microsoft Access 2007, which contain all the items and

  9. Canada's hydrocarbon processing evolution

    International Nuclear Information System (INIS)

    Wise, T.H.; Horton, R.

    2000-01-01

    The development of petroleum refining, petrochemicals and natural gas industries in Canada are discussed together with future issues and prospects. Figures give data on (a) refined products trade 1998; (b) refining capacity; (c) product demand 1980-1999; (d) refinery crude runs and capacity; (e) refining and marketing, historical returns 1993-1999; (f) processing power index for Canada and USA; (g) ethylene capacity; (eye) Montreal petrochemical capacities; (j) Sarnia petrochemical capacities in 2000; (k) Alberta petrochemicals capacities 2001; (l) ethylene net equivalent trade; (m) ethylene costs 1999 for W. Canada and other countries. It was concluded that the hydrocarbon processing business continues to expand in Canada and natural gas processing is likely to increase. Petrochemicals may expand in W. Canada, possibly using feed stock from the Far North. Offshore developments may stimulate new processing on the E. Coast

  10. Energy in Canada

    International Nuclear Information System (INIS)

    1987-11-01

    This discussion paper was prepared by the Department of Energy, Mines and Resources Canada to provide information about Canada's resource potential, the contribution of energy to the Canadian economy, Canada's place in the world energy market, and the outlook for the development of Canadian energy resources. In addition, it provides background information on issues such as: energy and the environment, energy security, Canadian ownership of energy resources, energy R and D, and energy conservation. Finally, it concludes with an indication of some of the key challenges facing the energy sector. The paper is intended to inform the public and to serve as a reference document for those participating in the review of Canada's energy options. The paper was prepared before Canada and the U.S. agreed in principle on a free trade agreement (FTA) and does not include a discussion of the FTA or its potential impacts on the energy sector

  11. CREATINE PHOSPHOKINASE ISOENZYME-MB MASS (CK-MB MASS AND TROPONIN I (cTnI IN DOGS (Canis familiaris

    Directory of Open Access Journals (Sweden)

    Millena Vidal Freitas

    2015-07-01

    Full Text Available Cardiac markers, especially CK-MB mass and cTnI, have an essential role in both human and veterinary clinical and surgical cardiology, allowing a more precise and accurate diagnosis in myocardial lesions. The goal of this work was to measure these cardiac markers in veterinary medicine, improve their use and provide information about these laboratory methods that allow non-invasive health monitoring of the myocardial cell. Parameters quantification was obtained from sera of healthy dogs examined during routine procedures at the Small Animal Veterinary Hospital of Universidade Estadual do Norte Fluminense Darcy Ribeiro. The human chemiluminescence essay turbo kit (IMMULITE Turbo, Siemens ® test proved to be effective in canine species for both CK-MB mass and cTnI. In addition, the values found for CK-MB will significantly contribute to clinical routine or experimental work with dogs.

  12. Identification of possible factors impacting dental students' ability to locate MB2 canals in maxillary molars.

    Science.gov (United States)

    Park, Ellen; Chehroudi, Babak; Coil, Jeffrey M

    2014-05-01

    This study examined the effect of the access size and straight-line path of access on third-year dental students' ability to locate a second mesiobuccal (MB2) canal in maxillary first and second molars. One hundred and six third-year dental students at one Faculty of Dentistry performed simulated root canal treatment with the aid of 2x magnification loupes on extracted teeth. A postgraduate endodontic student subsequently made a reasonable search for an untreated MB2 canal with the aid of a dental operating microscope. The mesiobuccal roots were then sectioned horizontally for determination of the canal configuration. The dental students were able to treat an MB2 canal in 15.8 percent of the teeth, but this was not associated with satisfactory access criteria. The postgraduate endodontic student identified an MB2 canal in 54.7 percent of the remaining tooth samples excluding those where the MB2 canal was found by the dental students; this represented 94.3 percent of those teeth confirmed by horizontal sectioning of the root to have an MB2 canal. The postgraduate student troughed, on average, 2.6 mm before negotiating the MB2 canal. As satisfactory access criteria and straight-line path of access did not correlate with the dental students' ability to find a second mesiobuccal canal, this result has important implications for educational goals with respect to endodontic treatment of maxillary molar teeth.

  13. ATLAS-Canada Network

    Energy Technology Data Exchange (ETDEWEB)

    Gable, I; Sobie, R J [HEPnet/Canada, Victoria, BC (Canada); Bedinelli, M; Butterworth, S; Groer, L; Kupchinsky, V [University of Toronto, Toronto, ON (Canada); Caron, B; McDonald, S; Payne, C [TRIUMF Laboratory, Vancouver, BC (Canada); Chambers, R [University of Alberta, Edmonton, AB (Canada); Fitzgerald, B [University of Victoria, Victoria, BC (Canada); Hatem, R; Marshall, P; Pobric, D [CANARIE Inc., Ottawa, ON (Canada); Maddalena, P; Mercure, P; Robertson, S; Rochefort, M [McGill University, Montreal, QC (Canada); McWilliam, D [BCNet, Vancouver, BC (Canada); Siegert, M [Simon Fraser University, Burnaby, BC (Canada)], E-mail: igable@uvic.ca (and others)

    2008-12-15

    The ATLAS-Canada computing model consists of a WLCG Tier-1 computing centre located at the TRIUMF Laboratory in Vancouver, Canada, and two distributed Tier-2 computing centres in eastern and western Canadian universities. The TRIUMF Tier-1 is connected to the CERN Tier-0 via a 10G dedicated circuit provided by CANARIE. The Canadian institutions hosting Tier-2 facilities are connected to TRIUMF via 1G lightpaths, and routing between Tier-2s occurs through TRIUMF. This paper discusses the architecture of the ATLAS-Canada network, the challenges of building the network, and the future plans.

  14. Canada's nuclear export policy

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, R W; Wonder, E F [Carleton Univ., Ottawa, Ontario (Canada)

    1978-01-01

    The factors influencing the evolution of Canada's nuclear export policy are examined. Initially, nuclear technology was exported to establish an industry in Canada and to share the technology with other countries. After 1974 an increasingly broad range of political and social factors were taken into account and safeguards became the dominant factor. The indirect impacts of the new policy fall into two groups. One consists of the effects of Canada's leadership in taking a tough stand on safeguards. The second group of effects involve the concern of other countries about access to secure energy supplies and advanced technology.

  15. Canada's nuclear export policy

    International Nuclear Information System (INIS)

    Morrison, R.W.; Wonder, E.F.

    1978-01-01

    The factors influencing the evolution of Canada's nuclear export policy are examined. Initially, nuclear technology was exported to establish an industry in Canada and to share the technology with other countries. After 1974 an increasingly broad range of political and social factors were taken into account and safeguards became the dominant factor. The indirect impacts of the new policy fall into two groups. One consists of the effects of Canada's leadership in taking a tough stand on safeguards. The second group of effects involve the concern of other countries about access to secure energy supplies and advanced technology. (O.T.)

  16. Radiation oncology in Canada.

    Science.gov (United States)

    Giuliani, Meredith; Gospodarowicz, Mary

    2018-01-01

    In this article we provide an overview of the Canadian healthcare system and the cancer care system in Canada as it pertains to the governance, funding and delivery of radiotherapy programmes. We also review the training and practice for radiation oncologists, medical physicists and radiation therapists in Canada. We describe the clinical practice of radiation medicine from patients' referral, assessment, case conferences and the radiotherapy process. Finally, we provide an overview of the practice culture for Radiation Oncology in Canada. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. Canada's hydrogen energy sector

    International Nuclear Information System (INIS)

    Kimmel, T.B.

    2009-01-01

    Canada produces the most hydrogen per capita of any Organization of Economic Cooperation and Development (OECD) country. The majority of this hydrogen is produced by steam methane reforming for industrial use (predominantly oil upgrading and fertilizer production). Canada also has a world leading hydrogen and fuel cell sector. This sector is seeking new methods for making hydrogen for its future energy needs. The paper will discuss Canada's hydrogen and fuel cell sector in the context of its capabilities, its demonstration and commercialization activities and its stature on the world stage. (author)

  18. Canada's nuclear power programme

    International Nuclear Information System (INIS)

    Peden, W.

    1976-01-01

    Although Canada has developed the CANDU type reactor, and has an ambitious programme of nuclear power plant construction, there has been virtually no nuclear controversy. This progress was seen as a means to bring Canada out of the 'resource cow' era, and onto a more equal footing with technologically elite nations. However the Indian nuclear explosion test, waste storage problems, contamination problems arising from use of uranium ore processing waste as land fill and subsidised sale of nuclear power plants to Argentina and South Korea have initiated public and parliamentary interest. Some economists have also maintained that Canada is approaching over-supply of nuclear power and over-investment in plant. Canada has no official overall energy production plan and alternative sources have not been evaluated. (JIW)

  19. Fusion Canada issue 20

    International Nuclear Information System (INIS)

    1993-03-01

    Fusion Canada's publication of the National Fusion Program. Included in this issue is the CFFTP Industrial Impact Study, CCFM/TdeV Update:helium pumping, research funds, and deuterium in beryllium - high temperature behaviour. 3 figs

  20. Wait times in Canada.

    Science.gov (United States)

    MacKinnon, Janice Christine

    2017-07-01

    A significant barrier to accessing healthcare in Canada is long waiting lists, which can be linked to the way that Medicare was structured. After significant pressure, provincial governments began to address wait times. An example of a successful strategy to reduce wait times for elective surgery is the Saskatchewan Surgical Initiative, which saw wait times in the province change from being among the longest in Canada to the shortest.

  1. Canada's radiation scandal?

    International Nuclear Information System (INIS)

    1990-12-01

    In July 1990, Greenpeace distributed a 16-page treatise entitled 'Canada's Radiation Scandal' to a wide audience. The bottom line of the Greenpeace critique was that 'Canada's radiation limits are among the worst in the developed world'. This is a commentary on the Greenpeace pamphlet from the Atomic Energy Control Board (AECB), the body that sets and enforces radiation standards covering the use of nuclear energy in Canadian industry, science and medicine

  2. Uranium in Canada

    International Nuclear Information System (INIS)

    1985-09-01

    In 1974 the Minister of Energy, Mines and Resources (EMR) established a Uranium Resource Appraisal Group (URAG) within EMR to audit annually Canada's uranium resources for the purpose of implementing the federal government's uranium export policy. A major objective of this policy was to ensure that Canadian uranium supplies would be sufficient to meet the needs of Canada's nuclear power program. As projections of installed nuclear power growth in Canada over the long term have been successively revised downwards (the concern about domestic security of supply is less relevant now than it was 10 years ago) and as Canadian uranium supply capabilities have expanded significantly. Canada has maintained its status as the western world's leading exporter of uranium and has become the world's leading producer. Domestic uranium resource estimates have increased to 551 000 tonnes U recoverable from mineable ore since URAG completed its last formal assessment (1982). In 1984, Canada's five primary uranium producers employed some 5800 people at their mining and milling operations, and produced concentrates containing some 11 170 tU. It is evident from URAG's 1984 assessment that Canada's known uranium resources, recoverable at uranium prices of $150/kg U or less, are more than sufficient to meet the 30-year fuelling requirements of those reactors that are either in opertaion now or committed or expected to be in-service by 1995. A substantial portion of Canada's identified uranium resources, recoverable within the same price range, is thus surplus to Canadian needs and available for export. Sales worth close to $1 billion annually are assured. Uranium exploration expenditures in Canada in 1983 and 1984 were an estimated $41 million and $35 million, respectively, down markedly from the $128 million reported for 1980. Exploration drilling and surface development drilling in 1983 and 1984 were reported to be 153 000 m and 197 000 m, respectively, some 85% of which was in

  3. Non-Gaussian diffusion MR imaging of glioma: comparisons of multiple diffusion parameters and correlation with histologic grade and MIB-1 (Ki-67 labeling) index

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Ren; Haopeng, Pang; Xiaoyuan, Feng; Jiawen, Zhang; Zhenwei, Yao [Fudan University, Department of Radiology, Huashan Hospital, Shanghai (China); Jinsong, Wu; Chengjun, Yao; Tianming, Qiu [Fudan University, Department of Neurosurgery, Huashan Hospital, Shanghai (China); Ji, Xiong [Fudan University, Department of Neuropathology, Huashan Hospital, Shanghai (China); Mao, Sheng; Yueyue, Ding [Department of Imaging, Suzhou Children' s Hospital, Suzhou, Jiangsu (China); Yong, Zhang [MR Research, GE Healthcare, Shanghai (China); Jianfeng, Luo [Fudan University, Department of Biostatistics, Public Health School, Shanghai (China)

    2016-02-15

    This study was conducted to compare the association of Gaussian and non-Gaussian magnetic resonance imaging (MRI)-derived parameters with histologic grade and MIB-1 (Ki-67 labeling) index (MI) in brain glioma. Sixty-five patients with pathologically confirmed glioma, who underwent diffusion-weighted MRI with 2 b values (0, 1000 s/mm{sup 2}) and 22 b values (≤5000 s/mm{sup 2}), respectively, were divided into three groups of grade II (n = 35), grade III (n = 8), and grade IV (n = 22). Comparisons by two groups were made for apparent diffusion coefficient (ADC), slow diffusion coefficient (Dslow), distributed diffusion coefficient (DDC), and heterogeneity index α. Analyses of receiver operating characteristic (ROC) curve were performed to maximize the area under the curve (AUC) for differentiating grade III + IV (high-grade glioma, HGG) from grade II (low-grade glioma, LGG) and grade IV (glioblastoma multiforme, GBM) from grade II + III (other grade glioma, OGG). Correlations with MI were analyzed for the MRI parameters. On tumor regions, the values of ADC, Dslow, DDC, and α were significantly higher in grade II [(1.37 ± 0.29, 0.70 ± 0.11, 1.39 ± 0.34) (x 10{sup -3} mm{sup 2}/s) and 0.88 ± 0.05, respectively] than in grade III [(0.99 ± 0.13, 0.55 ± 0.07, 1.04 ± 0.20) (x 10{sup -3} mm{sup 2}/s) and 0.80 ± 0.03, respectively] and grade IV [(1.03 ± 0.14, 0.50 ± 0.05, 1.02 ± 0.16) (x 10{sup -3} mm{sup 2}/s) and 0.76 ± 0.04, respectively] (all P < 0.001). The parameter α showed the highest AUCs of 0.950 and 0.922 in discriminating HGG from LGG and GBM from OGG, respectively. Significant correlations with histologic grade and MI were observed for the MRI parameters. The non-Gaussian MRI-derived parameters α and Dslow are superior to ADC in glioma grading, which are comparable with ADC as reliable biomarkers in noninvasively predicting the proliferation level of glioma malignancy. (orig.)

  4. Non-Gaussian diffusion MR imaging of glioma: comparisons of multiple diffusion parameters and correlation with histologic grade and MIB-1 (Ki-67 labeling) index

    International Nuclear Information System (INIS)

    Yan, Ren; Haopeng, Pang; Xiaoyuan, Feng; Jiawen, Zhang; Zhenwei, Yao; Jinsong, Wu; Chengjun, Yao; Tianming, Qiu; Ji, Xiong; Mao, Sheng; Yueyue, Ding; Yong, Zhang; Jianfeng, Luo

    2016-01-01

    This study was conducted to compare the association of Gaussian and non-Gaussian magnetic resonance imaging (MRI)-derived parameters with histologic grade and MIB-1 (Ki-67 labeling) index (MI) in brain glioma. Sixty-five patients with pathologically confirmed glioma, who underwent diffusion-weighted MRI with 2 b values (0, 1000 s/mm 2 ) and 22 b values (≤5000 s/mm 2 ), respectively, were divided into three groups of grade II (n = 35), grade III (n = 8), and grade IV (n = 22). Comparisons by two groups were made for apparent diffusion coefficient (ADC), slow diffusion coefficient (Dslow), distributed diffusion coefficient (DDC), and heterogeneity index α. Analyses of receiver operating characteristic (ROC) curve were performed to maximize the area under the curve (AUC) for differentiating grade III + IV (high-grade glioma, HGG) from grade II (low-grade glioma, LGG) and grade IV (glioblastoma multiforme, GBM) from grade II + III (other grade glioma, OGG). Correlations with MI were analyzed for the MRI parameters. On tumor regions, the values of ADC, Dslow, DDC, and α were significantly higher in grade II [(1.37 ± 0.29, 0.70 ± 0.11, 1.39 ± 0.34) (x 10 -3 mm 2 /s) and 0.88 ± 0.05, respectively] than in grade III [(0.99 ± 0.13, 0.55 ± 0.07, 1.04 ± 0.20) (x 10 -3 mm 2 /s) and 0.80 ± 0.03, respectively] and grade IV [(1.03 ± 0.14, 0.50 ± 0.05, 1.02 ± 0.16) (x 10 -3 mm 2 /s) and 0.76 ± 0.04, respectively] (all P < 0.001). The parameter α showed the highest AUCs of 0.950 and 0.922 in discriminating HGG from LGG and GBM from OGG, respectively. Significant correlations with histologic grade and MI were observed for the MRI parameters. The non-Gaussian MRI-derived parameters α and Dslow are superior to ADC in glioma grading, which are comparable with ADC as reliable biomarkers in noninvasively predicting the proliferation level of glioma malignancy. (orig.)

  5. Terrorism in Canada.

    Science.gov (United States)

    Kollek, Daniel

    2003-01-01

    This paper reviews terrorism in Canada, assessing the incidence and nature of terrorist activity, the potential targets of terrorist attacks, risk factors to Canadian nationals and institutions, and the responses of the Canadian government in dealing with the threat and the effectiveness of those responses. Despite the fact that there have been no recent high-profile terrorist events in Canada, this country has a serious terrorism problem, the key manifestation of which is the multitude of terrorist organizations that have designated Canada as a base of operations. In addition, Canadians have been attacked overseas and Canadian organizations, both local and abroad, are potential targets of terrorist activity. Canadian attempts to deal with terrorism through foreign and domestic policy have been ineffective, primarily because the policies have been poorly enforced. Until recently, terrorist organizations legally could raise funds in Canada, in direct contravention of international treaties signed by Canada. It is possible that the ineffectiveness in enforcing the anti-terrorism legislation stems from hope that placating terrorist organizations, and the countries that support them, will prevent Canada from becoming a target. Unfortunately evidence from other countries has shown this strategy to be ineffective.

  6. STS-48 MS Gemar uses laptop during training session in JSC's MB SMS

    Science.gov (United States)

    1991-01-01

    STS-48 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) Charles D. Gemar, wearing lightweight headset, enters data into a portable laptop computer on the middeck of JSC's Motion Based (MB) Shuttle Mission Simulator (SMS). Gemar is participating in a preflight familiarization session in the MB-SMS located in the Mission Simulation and Training Facility Bldg 5. Visible to Gemar's right is a stowed extravehicular mobility unit (EMU) and on his left are forward locker mockups.

  7. Assessment of Contaminated Brine Fate and Transport in MB139 at WIPP

    Energy Technology Data Exchange (ETDEWEB)

    Kuhlman, Kristopher L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Applied Systems Analysis and Research Dept.; Malama, Bwalya [Sandia National Lab., Carlsbad, NM (United States). Performance Assessment Dept.

    2014-07-01

    Following the radionuclide release event of February 14, 2014 at the Waste Isolation Pilot Plant (WIPP), actinide contamination has been found on the walls and floor in Panel 7 as a result of a release in Room 7 of Panel 7. It has been proposed to decontaminate Panel 7 at the WIPP by washing contaminated surfaces in the underground with fresh water. A cost-effective cleanup of this contamination would allow for a timely return to waste disposal operations at WIPP. It is expected that the fresh water used to decontaminate Panel 7 will flow as contaminated brine down into the porosity of the materials under the floor – the run-of-mine (ROM) salt above Marker Bed 139 (MB139) and MB139 itself – where its fate will be controlled by the hydraulic and transport properties of MB139. Due to the structural dip of MB139, it is unlikely that this brine would migrate northward towards the Waste-Handling Shaft sump. A few strategically placed shallow small-diameter observation boreholes straddling MB139 would allow for monitoring the flow and fate of this brine after decontamination. Additionally, given that flow through the compacted ROM salt floor and in MB139 would occur under unsaturated (or two-phase) conditions, there is a need to measure the unsaturated flow properties of crushed WIPP salt and salt from the disturbed rock zone (DRZ).

  8. Uranium in Canada

    International Nuclear Information System (INIS)

    1987-09-01

    Canadian uranium exploration and development efforts in 1985 and 1986 resulted in a significant increase in estimates of measured uranium resources. New discoveries have more than made up for production during 1985 and 1986, and for the elimination of some resources from the overall estimates, due to the sustained upward pressure on production costs and the stagnation of uranium prices in real terms. Canada possesses a large portion of the world's uranium resources that are of current economic interest and remains the major focus of inter-national uranium exploration activity. Expenditures for uranium exploration in Canada in 1985 and 1986 were $32 million and $33 million, respectively. Although much lower than the $130 million total reported for 1979, expenditures for 1987 are forecast to increase. Exploration and surface development drilling in 1985 and 1986 were reported to be 183 000 m and 165σ2 000 m, respectively, 85 per cent of which was in Saskatchewan. Canada has maintained its position as the world's leading producer and exporter of uranium. By the year 2000, Canada's annual uranium requirements will be about 2 100 tU. Canada's known uranium resources are more than sufficient to meet the 30-year fuel requirements of those reactors in Canada that are either in operation now or expected to be in service by the late 1990s. A substantial portion of Canada's identified uranium resources is thus surplus to Canadian needs and available for export. Annual sales currently approach $1 billion, of which exports account for 85 per cent. Forward domestic and export contract commitments totalled 73 000 tU and 62 000 tU, respectively, as of early 1987

  9. Konzeption einer Service-MIB

    OpenAIRE

    Sailer, Martin

    2007-01-01

    In den letzten Jahren ließ sich ein starker Trend hin zum dienstorientierten Management verzeichnen. Betreiber von IT-Diensten gehen verstärkt dazu über, den Betrieb ihrer Infrastrukturen an technischen und organisatorischen Dienstmanagementkonzepten auszurichten und versuchen dadurch, den durch gesteigerte Kundenbedürfnisse und komplexere Diensterbringungsszenarien induzierten Rahmenbedingen zu begegnen. Mit der Einführung neuer Dienstmanagementsysteme wächst allerdings gleichzeitig de...

  10. Canada's uranium policies

    International Nuclear Information System (INIS)

    Smith, K.L.; Williams, R.M.

    1991-01-01

    The purpose of this paper is to provide an update on the Canadian Government policies which affect the uranium industry and, where appropriate, to provide some background on the development of these policies. This review is timely because of two recent announcements by the Minister of Energy, Mines and Resources - one concerning the Canadian Government's renewed commitment to maintain the nuclear power option for Canada, and the other concerning some adjustments to Canada's uranium export policy. The future of Canada's nuclear industry was subject to a thorough review by the Canadian Government during 1989. This review occurred at a time when environmental issues were attracting increasing attention around the world, and the environmental advantages of nuclear power were becoming increasingly recognised. The strong support for the nuclear industry in Canada is consistent with the government's long-standing efforts to maintain Canada's position as a reliable and competitive supplier of uranium. This paper is particularly devoted to an outline of the results of the uranium export policy review. (author)

  11. Building Canada: Phase One

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2004-04-15

    The 'Building Canada' program modelled after the 'Building America' program, aims at increasing energy efficiency and affordability, primarily for single family homes. The program takes a holistic and whole house view, employing a systems approach and is committed to continuous improvement through testing, evaluation, retesting and novel construction practices. The program's objective is to re-engineer house designs so that builders can take advantage of advanced products and achieve maximum efficiency. Building Canada aims to achieve its objectives through partnership with the housing industry, focusing on increasing energy efficiency while reducing construction time, using and wasting fewer materials, forestalling call backs, and reducing overall costs. The Building Canada procedures encompass marketing, research of builder's operations, re-engineering mechanical systems, framing components and techniques, moisture control and thermal performance, construction, resolution of problems in re-engineered homes, and discussion of results in demonstration homes. The program as a whole is built on the feasibility study of a Building Canada program carried out in Nova Scotia and Ontario. Some of the results of this pilot study summarized in this report indicate that the Building Canada is not suitable for use by small builders. Benefits are most likely to be realized by only by builders constructing more than 100 homes annually.

  12. Canada's domestic nuclear issues

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The Interfaith Program for Public Awareness of Nuclear Issues (IPPANI) is a committee of representatives of religious groups in Toronto, a group of people concerned about the moral and ethical implications of the operation of Canada's nuclear industry and of its exports to other countries. The faith groups represented are the Anglican Diocese of Toronto, the Baha'i Community of Canada, the Jewish Community of Toronto, the Roman Catholic Archdiocese of Toronto and the United Church of Canada Toronto Conference. Wishing to encourage the Canadian government to enquire into this broad question, the faith groups established IPPANI and assigned to it the task of enhancing their knowledge of the nuclear industry. IPPANI was to develop an effective set of questions to be placed before governments and to promote public discussion so that governments might become more responsive to these issues

  13. Cardiac Rehabilitation Series: Canada

    Science.gov (United States)

    Grace, Sherry L.; Bennett, Stephanie; Ardern, Chris I.; Clark, Alexander

    2015-01-01

    Cardiovascular disease is among the leading causes of mortality and morbidity in Canada. Cardiac rehabilitation (CR) has a long robust history here, and there are established clinical practice guidelines. While the effectiveness of CR in the Canadian context is clear, only 34% of eligible patients participate, and strategies to increase access for under-represented groups (e.g., women, ethnic minority groups) are not yet universally applied. Identified CR barriers include lack of referral and physician recommendation, travel and distance, and low perceived need. Indeed there is now a national policy position recommending systematic inpatient referral to CR in Canada. Recent development of 30 CR Quality Indicators and the burgeoning national CR registry will enable further measurement and improvement of the quality of CR care in Canada. Finally, the Canadian Association of CR is one of the founding members of the International Council of Cardiovascular Prevention and Rehabilitation, to promote CR globally. PMID:24607018

  14. Canada Among Nations 2014. Crisis and Reform: Canada and the ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    28 mai 2014 ... This 28th edition of the Canada Among Nations series examines the 2008 global financial crisis, its impact on Canada, and the country's historic and current role in the international financial system.

  15. A case of spuriously high CK-MB: Contemplate beyond cardiac

    Directory of Open Access Journals (Sweden)

    Rishard Abdul

    2017-10-01

    Full Text Available Creatine kinase-MB (CK-MB is a widely tested enzyme in cardiac disease and thus has important clinical implications. We relate the scenario of a young patient presenting with chest pain whose CK-MB levels remained inordinately elevated despite a normal total CK level, resolution of symptoms and exclusion of coronary artery disease. Further analysis by electrophoresis revealed the presence of a rare molecular variant of creatine kinase: macro-CK type 1. While this may be a benign finding, there are sparse data demonstrating an association with non-cardiac pathologies such as malignancy, endocrinopathies, connective tissue and autoimmune diseases. Thus, after further exclusion of these associated conditions, the patient was reassured on the likely benign nature of macro-CK in this case.

  16. Nuclear power in Canada

    International Nuclear Information System (INIS)

    1980-01-01

    The Canadian Nuclear Association believes that the CANDU nuclear power generation system can play a major role in achieving energy self-sufficiency in Canada. The benefits of nuclear power, factors affecting projections of electric power demand, risks and benefits relative to other conventional and non-conventional energy sources, power economics, and uranium supply are discussed from a Canadian perspective. (LL)

  17. Fusion Canada issue 7

    International Nuclear Information System (INIS)

    1989-05-01

    A short bulletin from the National Fusion Program. Included in this issue are CFFTP highlights on the Karlsruhe Isotope Separation System, a report on ITER tritium process systems, an experimental update on Tokamak de Varennes and Canada-U.S. bilateral technical collaboration topics. 2 figs

  18. Fusion Canada issue 17

    International Nuclear Information System (INIS)

    1992-05-01

    A short bulletin from the National Fusion Program. Included in this issue is a report on increased funding for the Canadian Fusion Program, news of the compact Toroid fuelling gun, an update on Tokamak de Varennes, the Canada - U.S. fusion meeting, measurements of plasma flow velocity, and replaceable Tokamak divertors. 4 figs

  19. Fusion Canada issue 9

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-11-01

    A short bulletin from the National Fusion Program. Included in this issue is a report on availability of Canadian Tritium, an ITER update, a CCFM update on Tokamak and the new team organization, an international report on Fusion in Canada and a Laser Fusion Project at the University of Toronto. 3 figs.

  20. Suicide in Canada

    National Research Council Canada - National Science Library

    Leenaars, Antoon A

    1998-01-01

    ... provides long-awaited information that focuses specifically on Canada. It addresses suicide as a multidimensional problem with biological, psychological, cultural, sociological, personal, and philosophical aspects. The contributions integrate both critical analysis and personal experience. There are accounts from Inuit elders, fr...

  1. Fusion Canada issue 22

    International Nuclear Information System (INIS)

    1993-10-01

    A short bulletin from the National Fusion Program highlighting in this issue a bi-lateral meeting between Canada and Japan, water and hydrogen detritiation, in-situ tokamak surface analysis, an update of CCFM/TdeV and tritium accounting Industry guidance in Fusion, fast probe for plasma-surface interaction. 4 figs

  2. Fusion Canada issue 28

    International Nuclear Information System (INIS)

    1995-06-01

    A short bulletin from the National Fusion Program highlighting in this issue the Canada - US fusion meeting in Montreal, fusion breeder work in Chile, new management at CFFTP, fast electrons in tokamaks: new data from TdeV, a program review of CCFM and Velikhov to address Montreal fusion meeting. 1 fig

  3. Fusion Canada issue 17

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-05-01

    A short bulletin from the National Fusion Program. Included in this issue is a report on increased funding for the Canadian Fusion Program, news of the compact Toroid fuelling gun, an update on Tokamak de Varennes, the Canada - U.S. fusion meeting, measurements of plasma flow velocity, and replaceable Tokamak divertors. 4 figs.

  4. Coal in Canada

    International Nuclear Information System (INIS)

    Salaff, S.

    1991-01-01

    This article examines the potential market for coal-fired independent power projects in western Canada. The topics of the article include emissions issues, export potential for power produced, and financial and other assistance to independent power producers offered by British Columbia Hydro and coal mining companies in the region, including financing of projects and power distribution services including connecting to the USA grids

  5. Fusion Canada issue 7

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-05-01

    A short bulletin from the National Fusion Program. Included in this issue are CFFTP highlights on the Karlsruhe Isotope Separation System, a report on ITER tritium process systems, an experimental update on Tokamak de Varennes and Canada-U.S. bilateral technical collaboration topics. 2 figs.

  6. Nuclear technology in Canada

    International Nuclear Information System (INIS)

    1983-01-01

    This pamphlet provides a summary of the research being carried out by Atomic Energy of Canada Limited. The design and development of the CANDU type reactor are highlighted and the contribution of nuclear technology to medicine, agriculture and the Canadian economy is briefly discussed

  7. Fusion Canada issue 26

    International Nuclear Information System (INIS)

    1994-11-01

    A short bulletin from the National Fusion Program highlighting in this issue tritium supply for Japanese research, Canada to host the 1995 IAEA Conference on Tritium, studies on the tokamak divertor and edge plasma studies, a tritium field release study, erosion studies on plasma facing materials, G. Pacher returns to CCFM and an update on CCFM/TdeV

  8. Indian Arts in Canada

    Science.gov (United States)

    Tawow, 1974

    1974-01-01

    A recent publication, "Indian Arts in Canada", examines some of the forces, both past and present, which are not only affecting American Indian artists today, but which will also profoundly influence their future. The review presents a few of the illustrations used in the book, along with the Introduction and the Foreword. (KM)

  9. The butterflies of Canada

    National Research Council Canada - National Science Library

    Layberry, Ross A; Hall, Peter W; Lafontaine, J. Donald

    1998-01-01

    ... for the close to three hundred butterfly species recorded in Canada, including descriptions of early stages, subspecies, and key features that help distinguish similar species. Each species of butterfly has an individual distribution map, generated from a database of more than 90,000 location records. More than just a field guide to identifying Canadian butterfli...

  10. Fusion Canada issue 22

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-10-01

    A short bulletin from the National Fusion Program highlighting in this issue a bi-lateral meeting between Canada and Japan, water and hydrogen detritiation, in-situ tokamak surface analysis, an update of CCFM/TdeV and tritium accounting Industry guidance in Fusion, fast probe for plasma-surface interaction. 4 figs.

  11. Fusion Canada issue 9

    International Nuclear Information System (INIS)

    1989-11-01

    A short bulletin from the National Fusion Program. Included in this issue is a report on availability of Canadian Tritium, an ITER update, a CCFM update on Tokamak and the new team organization, an international report on Fusion in Canada and a Laser Fusion Project at the University of Toronto. 3 figs

  12. Gender differences in serum CK-MB mass levels in healthy Braziliansubjects

    Directory of Open Access Journals (Sweden)

    C.M.C. Strunz

    2011-03-01

    Full Text Available The creatine kinase-isoenzyme MB (CK-MB mass assay is one of the laboratory tests used for the diagnosis of myocardial infarction. It is recommended, however, that reference limits should take gender and race into account. In the present study, we analyzed the plasma CK-MB mass and troponin levels of 244 healthy volunteers without a personal history of coronary artery disease and with no chronic diseases, muscular trauma or hypothyroidism, and not taking statins. The tests were performed with commercial kits, CK-MB mass turbo kit and Troponin I turbo kit, using the Immulite 1000 analyzer from Siemens Healthcare Diagnostic. The values were separated according to gender and showed significant differences by the Mann-Whitney test. Mean (± SD CK-MB mass values were 2.55 ± 1.09 for women (N = 121; age = 41.20 ± 10.13 years and 3.49 ± 1.41 ng/mL for men (N = 123; age = 38.16 ± 11.12 years. Gender-specific reference values at the 99th percentile level, according to the Medicalc statistical software, were 5.40 ng/mL for women and 7.13 ng/mL for men. The influence of race was not considered because of the high miscegenation of the Brazilian population. The CK-MB values obtained were higher than the 5.10 mg/mL proposed by the manufacturer of the laboratory kit. Therefore, decision limits should be related to population and gender in order to improve the specificity of this diagnostic tool, avoiding misclassification of patients

  13. Serum dosage of CPK-MB in dogs with ST deviation by chemiluminescence

    Directory of Open Access Journals (Sweden)

    André L.F. Santos

    2014-12-01

    Full Text Available Abstract: Although frequently in humans, hypoxic and ischemic heart diseases are poorly documented in dogs, with only few reports of acute myocardial infarction (AMI in this species. Some electrocardiographic findings might suggest myocardium hypoxia/ischemia, like ST segment elevation or depression, but there are no studies showing whether deviations in ST segment are associated to myocardial injury and serum increase of creatine phosphokinase (CPK-MB. In order to investigate possible myocardial cells injury in poor perfusion conditions, 38 dogs were studied, 20 with normal electrocardiogram and 18 with ST segment elevation or depression, recorded in lead II, at a paper speed of 50 mm/sec and N sensibility (1mV=1cm. Serum measurement of creatine phosphokinase isoenzyme MB (CPK-MB in normal dogs (group 1 determined control values (in ng/mL, which were compared to those obtained from dogs with deviation (group 2, which allowed confirmation or not of myocardial injury. CPK-MB mean values obtained from dogs in groups 1 and 2 were 0.540ng/ml (SD±0.890ng/mL and 0.440ng/mL (SD±1.106, respectively. At a significance level of 5%, the relation of CPK-MB with age, mass and total creatine phosphokinase (CPK-T was not significant in groups 1 and 2. CPK-MB showed no difference, at 5% level, between groups 1 and 2. In conclusion, it is possible to use the human chemiluminescent immunometric assay kit in canine species and that hypoxia/ischemia revealed by ST segment deviation does not mean significant myocardium injury.

  14. Canada`s greenhouse gas emissions inventory

    Energy Technology Data Exchange (ETDEWEB)

    Jaques, A. [Environment Canada, Ottawa, ON (Canada)

    1998-09-01

    In 1994, Canada was the seventh largest global emitter of CO{sub 2}. The Kyoto Protocol has made it necessary to continue to improve methods for developing emissions inventories. An emissions inventory was defined as `a comprehensive account of air pollutant emissions and associated data from sources within the inventory area over a specified time frame that can be used to determine the effect of emissions on the environment`. The general approach is to compile large-scale emission estimates under averaged conditions for collective sources and sectors, using data that is available on a sectoral, provincial and national basis. Ideally, continuous emission monitors should be used to develop emissions inventories. Other needed improvements include additional research on emissions data, and increased support for international negotiations on reporting policies and related methodologies, verification procedures and adjustments. 1 ref., 5 figs.

  15. Nuclear regulatory developments in Canada

    International Nuclear Information System (INIS)

    Binder, M.

    2012-01-01

    This paper from CNSC discusses nuclear regulatory developments in Canada. It starts with the Fukushima accident and the effect on the nuclear sector. It summarises what CNSC has done, what it has learned and their plans going forward. It has made recommendations to IAEA for international enhancements to regulatory procedures. It outline the activities of Canada's nuclear power plants, Canada's uranium projects, deep geological repository and waste management as well as nuclear research in Canada.

  16. Uranium in Canada

    International Nuclear Information System (INIS)

    1989-01-01

    In 1988 Canada's five uranium producers reported output of concentrate containing a record 12,470 metric tons of uranium (tU), or about one third of total Western world production. Shipments exceeded 13,200 tU, valued at $Cdn 1.1 billion. Most of Canada's uranium output is available for export for peaceful purposes, as domestic requirements represent about 15 percent of production. The six uranium marketers signed new sales contracts for over 11,000 tU, mostly destined for the United States. Annual exports peaked in 1987 at 12,790 tU, falling back to 10,430 tU in 1988. Forward domestic and export contract commitments were more than 70,000 tU and 60,000 tU, respectively, as of early 1989. The uranium industry in Canada was restructured and consolidated by merger and acquisition, including the formation of Cameco. Three uranium projects were also advanced. The Athabasca Basin is the primary target for the discovery of high-grade low-cost uranium deposits. Discovery of new reserves in 1987 and 1988 did not fully replace the record output over the two-year period. The estimate of overall resources as of January 1989 was down by 4 percent from January 1987 to a total (measured, indicated and inferred) of 544,000 tU. Exploration expenditures reached $Cdn 37 million in 1987 and $59 million in 1988, due largely to the test mining programs at the Cigar Lake and Midwest projects in Saskatchewan. Spot market prices fell to all-time lows from 1987 to mid-1989, and there is little sign of relief. Canadian uranium production capability could fall below 12,000 tU before the late 1990s; however, should market conditions warrant output could be increased beyond 15,000 tU. Canada's known uranium resources are more than sufficient to meet the 30-year fuel requirements of those reactors in Canada that are now or are expected to be in service by the late 1990s. There is significant potential for discovering additional uranium resources. Canada's uranium production is equivalent, in

  17. Canada country report

    International Nuclear Information System (INIS)

    Cottrill, Cheryl

    2008-01-01

    1 - Nuclear 2007 highlights: New Build Applications and Environmental Assessments (Ontario Power Generation (OPG), Bruce Power, Bruce Power Alberta), Refurbishments (Bruce Power's Bruce A Units 1 and 2 Restart Project, NB Power's Refurbishment of Point Lepreau, New Brunswick, Atomic Energy of Canada Limited (AECL) NRU 50. Anniversary, expansion of the solid radioactive waste storage facilities at Gentilly-2 nuclear generating station, Ontario Power Generation (OPG) Deep Geologic Repository..); 2. Nuclear overview: a. Energy policy (Future of nuclear power, state of the projects, schedule, Refurbishment), b. Public acceptance, Statements from Government Officials in Canada; c. Nuclear equipment (number and type); d. Nuclear waste management, Deep Geologic Repository; e. Nuclear research at AECL; f. Other nuclear activities (Cameco Corporation, MDS Nordion); 3. Nuclear competencies; 4. WIN 2007 Main Achievements: GIRLS Science Club, Skills Canada, WiN-Canada Web site, Book Launch, WINFO, 2007 WiN-Canada conference 4 - Summary: - 14.6% of Canada's electricity is provided by Candu nuclear reactors; Nuclear equipment: 10 Research or isotope producing reactors - Pool-Type; Slowpoke 2; Sub-Critical assembly; NRU; and Maple; 22 Candu reactors providing electricity production - 18 of which are currently operating. Public acceptance: 41% feel nuclear should play more of a role, 67% support refurbishment, 48% support new build, 13% point gender gap in support, with men supporting more than women. Energy policy: Future of nuclear power - recognition that nuclear is part of the solution across Canada; New Build - 3 applications to regulator to prepare a site for new build, in Provinces of Ontario and Alberta, with one feasibility study underway in New Brunswick; Refurbishment - Provinces of Ontario (2010) and New Brunswick (2009). Nuclear waste management policy: Proposal submitted to regulator to prepare, construct and operate a deep geologic disposal facility in Ontario

  18. Electric power in Canada 1992

    International Nuclear Information System (INIS)

    1993-01-01

    Electric power in Canada is given a comprehensive review by the Electricity Branch of the Department of Natural Resources Canada. The Electric Power Industry is scrutinized for electricity consumption, generation, trade and pricing across all of Canada. 98 tabs. 26 figs

  19. Electric power in Canada 1992

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    Electric power in Canada is given a comprehensive review by the Electricity Branch of the Department of Natural Resources Canada. The Electric Power Industry is scrutinized for electricity consumption, generation, trade and pricing across all of Canada. 98 tabs. 26 figs.

  20. The effects of prior calcium channel blocker therapy on creatine kinase-MB levels after percutaneous coronary interventions

    OpenAIRE

    Gulmez, Oyku; Atar, Ilyas; Ozin, B?lent; Korkmaz, Mehmet Emin; Atar, Asli; Aydinalp, Alp; Yildirir, Aylin; Muderrisoglu, Haldun

    2008-01-01

    Background: Use of intracoronary calcium channel blockers (CCBs) during percutaneous coronary intervention (PCI) has been shown to have favorable effects on coronary blood flow. We aimed to investigate the effects of CCBs administrated perorally on creatine kinase-MB (CK-MB) levels in patients undergoing elective PCI. Methods: A total of 570 patients who underwent PCI were evaluated for CK-MB elevation. Patients who were on CCB therapy when admitted to the hospital constituted the CCB group. ...

  1. Ovicidal activity of Metarhizium brunneum (Mb F52) on dengue fever vector, Aedes aegypti

    Science.gov (United States)

    The ovicidal activity of Metarhizium brunneum F52 (Mb F52) grown from granules was evaluated against Aedes aegypti eggs over time. Survival of larvae from treated eggs was significantly less when compared with untreated eggs at 7, 10 and 14 days post treatment. Only 27 % of treated eggs produced vi...

  2. Arrival at CERN of the first MB4 DT chambers from Turin

    CERN Multimedia

    Marcos Fernandez Garcia

    2005-01-01

    The largest DT chambers to be installed into the outermost station of the CMS barrel muon detector (MB4) are built by INFN-Turin. The first batch of four chambers, out of 40, arrived at the CERN ISR area on February 2005.

  3. 150 Mb/s wifi transmission over 50m large core diameter step index POF

    NARCIS (Netherlands)

    Shi, Y.; Nieto Munoz, M.; Okonkwo, C.M.; Boom, van den H.P.A.; Tangdiongga, E.; Koonen, A.M.J.

    2011-01-01

    We demonstrate successful transmission of WiFi signals over 50m step-index plastic optical fibre with 1mm core diameter employing an eye-safe resonant cavity light emitting diode and an avalanche photodetector. The EVM performance of 4.1% at signal data rate of 150Mb/s is achieved.

  4. CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells

    International Nuclear Information System (INIS)

    Androutsopoulos, Vasilis P.; Ruparelia, Ketan; Arroo, Randolph R.J.; Tsatsakis, Aristidis M.; Spandidos, Demetrios A.

    2009-01-01

    Among the different mechanisms proposed to explain the cancer-protecting effect of dietary flavonoids, substrate-like interactions with cytochrome P450 CYP1 enzymes have recently been explored. In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by recombinant CYP1A1, CYP1B1 and CYP1A2 enzymes, as well as their antiproliferative activity in MDA-MB-468 human breast adenocarcinoma and MCF-10A normal breast cell lines, were investigated. Baicalein and 6-hydroxyluteolin were the only conversion products of chrysin and scutellarein metabolism by CYP1 family enzymes, respectively, while baicalein itself was not metabolized further. Sinensetin and genkwanin produced a greater number of metabolites and were shown to inhibit strongly in vitro proliferation of MDA-MB-468 cells at submicromolar and micromolar concentrations, respectively, without essentially affecting the viability of MCF-10A cells. Cotreatment of the CYP1 family inhibitor acacetin reversed the antiproliferative activity noticed for the two flavones in MDA-MB-468 cells to 13 and 14 μM respectively. In contrast chrysin, baicalein and scutellarein inhibited proliferation of MDA-MB-468 cells to a lesser extent than sinensetin and genkwanin. The metabolism of genkwanin to apigenin and of chrysin to baicalein was favored by CYP1B1 and CYP1A1, respectively. Taken together the data suggests that CYP1 family enzymes enhance the antiproliferative activity of dietary flavonoids in breast cancer cells, through bioconversion to more active products.

  5. Experimental determination of neutron lifetimes through macroscopic neutron noise in the IPEN/MB-01 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Gonnelli, Eduardo; Diniz, Ricardo [Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP Travessa R-400, 05508-900, Cidade Universitaria, Sao Paulo (Brazil)

    2013-05-06

    The neutron lifetimes of the core, reflector, and global were experimentally obtained through macroscopic neutron noise in the IPEN/MB-01 reactor for five levels of subcriticality. The theoretical Auto Power Spectral Densities were derived by point kinetic equations taking the reflector effect into account, and one of the approaches consider an additional group of delayed neutrons.

  6. Reactivity effect of a heavy water tank as reflector in the IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Santos, Adimir dos; Fuga, Rinaldo

    2013-01-01

    This experiment comprises a set of experiments performed in the IPEN/MB-01 reactor and described in the International Handbook of Evaluated Reactor Physics Benchmark Experiments, specifically the experiment aim to evaluate the reactivity due to the heavy water tank placed at reflector region of the IPEN/MB-01 reactor. An aluminum tank was designed to be filled with heavy water and positioned at the west face of the IPEN/MB-01, additionally the experiment was also designed to allow variable heavy water height inside of this tank providing different neutron leakage rate in the west face of the IPEN/MB-01, consequently providing a series of interesting combinations. The measured quantities in the experiment are reactivities and critical control bank positions for several combinations of the control banks and an excess of reactivity of the heavy water tank. The experiment will be simulated using a Monte Carlo code MCNP in order to compare the different critical control bank position. (author)

  7. Contribution of creatine kinase MB mass concentration at admission to early diagnosis of acute myocardial infarction

    NARCIS (Netherlands)

    Bakker, A. J.; Gorgels, J. P.; van Vlies, B.; Koelemay, M. J.; Smits, R.; Tijssen, J. G.; Haagen, F. D.

    1994-01-01

    OBJECTIVE: To assess the diagnostic value at admission of creatine kinase MB mass concentration, alone or in combination with electrocardiographic changes, in suspected myocardial infarction. DESIGN: Prospective study of all consecutive patients admitted within 12 hours after onset of chest pain to

  8. Requirement of carbon dioxide for initial growth of facultative methylotroph, Acidomonas methanolica MB58.

    Science.gov (United States)

    Mitsui, Ryoji; Katayama, Hiroko; Tanaka, Mitsuo

    2015-07-01

    The facultative methylotrophic bacterium Acidomonas methanolica MB58 can utilize C1 compounds via the ribulose monophosphate pathway. A large gene cluster comprising three components related to C1 metabolism was found in the genome. From upstream, the first was an mxa cluster encoding proteins for oxidation of methanol to formaldehyde; the second was the rmp cluster encoding enzymes for formaldehyde fixation; and the third was the cbb gene cluster encoding proteins for carbon dioxide (CO2) fixation. Examination of CO2 requirements for growth of A. methanolica MB58 cells demonstrated that it did not grow on any carbon source under CO2-free conditions. Measurement of ribulose-1,5-bisphosphate carboxylase activity and RT-PCR analysis demonstrated enzymatic activity was detected in A. methanolica MB58 at growth phase, regardless of carbon sources. However, methanol dehydrogenase and 3-hexlose-6-phosphate synthase expression was regulated by methanol or formaldehyde; it were detected during growth and apparently differed from ribulose-1,5-bisphosphate carboxylase expression. These results suggested that A. methanolica MB58 may be initially dependent on autotrophic growth and that carbon assimilation was subsequently coupled with the ribulose monophosphate pathway at early- to mid-log phases during methylotrophic growth. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  9. Apoptotic Effect of the Urtica Dioica Plant Extracts on Breast Cancer Cell Line (MDA- MB- 468

    Directory of Open Access Journals (Sweden)

    A Mohammadi

    2015-09-01

    Full Text Available Background & objectives: Cancer is one of the most causes of mortality in worldwide. Components derived from natural plants that induce apoptosis are used for cancer treatment. Therefore investigation of different herbal components for new anti-cancer drug is one of the main research activities throughout the world. According to low cost, oral consumption and easy access to the public extracts of Urtica dioica, in this study we aimed to investigate the effectiveness of this herb on MDA-MB-468 breast cancer cells.   Methods: Cytotoxic effect of Urtica dioica extract was measured using MTT assays. To show induction of apoptosis by this plant TUNEL and DNA Fragmentation test were performed.   Results: In the present study dichloromethane extracts noticeably killed cancer cells. IC50 values related to human breast adenocarcinoma cell line MDA-MB-468 were 29.46±1.05 µg/ml in 24 hours and 15.54±1.04 µg/ml in 48 hours. TUNEL test and DNA Fragmentation assay showed apoptotic characteristic in the extract treated cells.   Conclusion: The results showed that MDA-MB-468 cells after treatment with dichloromethane extract of Urtica dioica, induces apoptosis in MDA-MB-468 cancer cells which may be useful in the treatment of cancer.

  10. STS-48 MS Buchli and MS Gemar on MB SMS middeck during JSC training session

    Science.gov (United States)

    1991-01-01

    STS-48 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) James F. Buchli (left) and MS Charles D. Gemar listen to instructions while on the middeck of JSC's Motion Based (MB) Shuttle Mission Simulator (SMS). Buchli and Gemar are reviewing inflight procedures during this preflight familiarization session held in the Mission Simulation and Training Facility Bldg 5.

  11. Uranium tailings in Canada

    International Nuclear Information System (INIS)

    Boulden, R.S.; Bragg, K.

    1982-01-01

    The last few years have produced significant changes in the way uranium tailings are managed in Canada. This is due both to the development of new technology and to changes in regulatory approach. The interrelationships between these two areas are examined with particular attention paid to the long term and the development of close-out criteria. New technological initiatives are examined including dry placement techniques, pit disposal and deep lake disposal

  12. Marketing Canada's coal

    Energy Technology Data Exchange (ETDEWEB)

    1985-11-01

    The topics are presented which were discussed at the 36th Canadian Coal Conference, held in Vancouver, BC in September 1985. The theme was Challenges, today and tomorrow and the conference sought to examine the primary problems confronting the world coal industry today: overcapacity, soft demand, depressed prices and intense global competition. Coal production in Canada was presented and its role in the steelmaking and electric power industries evaluated. A general mood of optimism prevailed.

  13. Electric deregulation in Canada

    International Nuclear Information System (INIS)

    Way, R.W.

    1996-01-01

    An outline of the electric power deregulation activities across Canada, particularly in Alberta, British Columbia, and Ontario, was presented. A central element of the restructuring is creation of a power pool which acts as an open spot market, and a transmission administrator that provides access to the generators, distribution companies, importers and exporters. Load forecasts, average daily load profile and hourly pool prices for TransAlta Corporation were presented as an example. 22 figs

  14. Plugging into Canada

    International Nuclear Information System (INIS)

    Hughes, W.R.

    1985-01-01

    Exports of electricity from Canada to the U.S.A. are increasing in importance and have reached a new phase with proposals to build generating stations initially dedicated to export, notably a second nuclear station in New Brunswick. The author considers that the National Energy Board does a good job of protecting Canadian interests. Opposition in the United States comes from within the government or congress rather than from the power industry or public

  15. Presentation of Canada

    International Nuclear Information System (INIS)

    Hedley, Dianne E.

    1997-01-01

    In contingency of a nuclear emergency event, requiring application of intervention measures on a federal scale, Canada has of a plan ensuring the compatibility of the plans of different provinces and serving as interface between federal and provincial authorities. Exclusive of a nuclear attack against North America, by nuclear emergency it is understood an accident resulting in radionuclide release. This is called the Plan of federal intervention in case of nuclear emergency. 'Sante Canada' is the federal authority responsible for intervention in case of nuclear emergency and it has the task of preparing and coordinating the actions on a federal scale.Should the plan be set in action and if the emergency has repercussions upon the agricultural sector, the sustaining organism will be 'Agriculture and agroalimentaire Canada' which in case of emergency acts through the channels of the National System of intervention in the agro-alimentary sector (SNIUA). The paper presents the objectives, the principles of organization and operation, the responsibilities and the plans which SNIUA has in its charge to implement in case of emergency

  16. Canada's reactor exports

    International Nuclear Information System (INIS)

    Morrison, R.W.

    1981-01-01

    A brief sketch of the development of Canada's nuclear exports is presented and some of the factors which influence the ability to export reactors have been identified. The potential market for CANDUs is small and will develop slowly. The competition will be tough. There are few good prospects for immediate export orders in the next two or three years. Nonetheless there are reasonable opportunities for CANDU exports, especially in the mid-to-late 1980s. Such sales could be of great benefit to Canada and could do much to sustain the domestic nuclear industry. Apart from its excellent economic and technical performance, the main attraction of the CANDU seems to be the autonomy it confers on purchasing countries, the effectiveness with which the associated technology can be transferred, and the diversification it offers to countries which wish to reduce their dependence on the major industrial suppliers. Each sales opportunity is unique, and marketing strategy will have to be tailored to the customer's needs. Over the next decade, the factors susceptible to Canadian government action which are most likely to influence CANDU exports will be the political commitment of the government to those reactor exports, the performance established by the four 600 MWe CANDUs now nearing completion, the continuing successful operation of the nuclear program in Ontario, and the co-ordination of the different components of Canada's nuclear program (AECL, nuclear industry, utilities, and government) in putting forth a coherent marketing effort and following through with effective project management

  17. Energy cascades in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Hayden, A. C.; Brown, T. D.

    1979-03-15

    Combining energy uses in a cascade can result in significant overall reductions in fuel requirements. The simplest applications for a cascade are in the recovery of waste heat from existing processes using special boilers or turbines. Specific applications of more-complex energy cascades for Canada are discussed. A combined-cycle plant at a chemical refinery in Ontario is world leader in energy efficiency. Total-energy systems for commercial buildings, such as one installed in a school in Western Canada, offer attractive energy and operating cost benefits. A cogeneration plant proposed for the National Capital Region, generating electricity as well as steam for district heating, allows the use of a low-grade fossil fuel (coal), greatly improves energy-transformation efficiency, and also utilizes an effectively renewable resource (municipal garbage). Despite the widespread availability of equipment and technology of energy cascades, the sale of steam and electricity across plant boundaries presents a barrier. More widespread use of cascades will require increased cooperation among industry, electric utilities and the various levels of government if Canada is to realize the high levels of energy efficiency potential available.

  18. Environmental performance reviews: Canada

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-09-01

    OECD's comprehensive 2004 report on Canada's environmental policies and programmes systematically examines policy related to air, water, and nature/biodiversity as well as the interface between environmental policy and economic policy, social policy, and specific sectors. It finds that while Canada has made satisfactory progress since 1985, there are still significant challenges, and the report makes specific recommendations for more use of economic instruments and use of the polluter and user pays principles, rationalising water governance, strengthening nature protection, reducing energy intensity, implementing climate change policies, reviewing environmentally related taxes, and implementing marine and aid commitments. Coal provides about 20% of Canada's electric power. Most direct subsidisation of the fossil fuel supply industries (upstream oil, gas and coal) has been reduced. The report recommends subsidies to the mining industry for exploration should also be phased out. Recent measurements indicate emissions of mercury are increasing, mainly due to long-range transboundary air pollution from coal-burning plants. 42 figs., 24 tabs.

  19. Canada's Global Partnership Program

    International Nuclear Information System (INIS)

    Ellis, M.

    2007-01-01

    Curbing the proliferation of biological weapons (BW) is an essential element of the Global Partnership Against the Spread of Weapons and Materials of Mass Destruction. At the Kananaskis Summit in June 2002, G8 Leaders committed to prevent terrorists, or those that harbour them, from acquiring or developing biological weapons and related materials, equipment and technology. To this end, Canada's Global Partnership Program is investing heavily in biological non-proliferation activities in countries of the former Soviet Union. A comprehensive strategy has been developed to help improve biological safety (biosafety) and biological security (biosecurity) with provision for addressing dual-use concerns. Raising awareness and creating a self-sustaining culture of biosecurity is a key driver of the program. Through this strategy, Canada is assisting various FSU countries to: develop and implement effective and practical biosafety/biosecurity standards and guidelines; establish national and/or regional biosafety associations; develop and deliver effective biosafety and biosecurity training; put in place enhanced physical security measures and equipment. In addition to biosafety and biosecurity, the GPP supports a broad range of Biological Non-Proliferation projects and initiatives, including dozens of projects aimed at redirecting former biological weapons scientists. To date, most of these activities have been supported through Canada's contribution to the International Science and Technology Center (ISTC) and the Science and Technology Centre Ukraine (STCU).(author)

  20. Pipelines to eastern Canada

    International Nuclear Information System (INIS)

    Otsason, J.

    1998-01-01

    This presentation focused on four main topics: (1) the existing path of pipelines to eastern Canada, (2) the Chicago hub, (3) transport alternatives, and (4) the Vector Pipeline' expansion plans. In the eastern Canadian market, TransCanada Pipelines dominates 96 per cent of the market share and is effectively immune to expansion costs. Issues regarding the attractiveness of the Chicago hub were addressed. One attractive feature is that the Chicago hub has access to multiple supply basins including western Canada, the Gulf Coast, the mid-continent, and the Rockies. Regarding Vector Pipelines' future plans, the company proposes to construct 343 miles of pipeline from Joliet, Illinois to Dawn, Ontario. Project description included discussion of some of the perceived advantages of this route, namely, extensive storage in Michigan and south-western Ontario, the fact that the proposed pipeline traverses major markets which would mitigate excess capacity concerns, arbitrage opportunities, cost effective expansion capability reducing tolls, and likely lower landed costs in Ontario. Project schedule, costs, rates and tariffs are also discussed. tabs., figs

  1. Improved protein quality in transgenic soybean expressing a de novo synthetic protein, MB-16.

    Science.gov (United States)

    Zhang, Yunfang; Schernthaner, Johann; Labbé, Natalie; Hefford, Mary A; Zhao, Jiping; Simmonds, Daina H

    2014-06-01

    To improve soybean [Glycine max (L.) Merrill] seed nutritional quality, a synthetic gene, MB-16 was introduced into the soybean genome to boost seed methionine content. MB-16, an 11 kDa de novo protein enriched in the essential amino acids (EAAs) methionine, threonine, lysine and leucine, was originally developed for expression in rumen bacteria. For efficient seed expression, constructs were designed using the soybean codon bias, with and without the KDEL ER retention sequence, and β-conglycinin or cruciferin seed specific protein storage promoters. Homozygous lines, with single locus integrations, were identified for several transgenic events. Transgene transmission and MB-16 protein expression were confirmed to the T5 and T7 generations, respectively. Quantitative RT-PCR analysis of developing seed showed that the transcript peaked in growing seed, 5-6 mm long, remained at this peak level to the full-sized green seed and then was significantly reduced in maturing yellow seed. Transformed events carrying constructs with the rumen bacteria codon preference showed the same transcription pattern as those with the soybean codon preference, but the transcript levels were lower at each developmental stage. MB-16 protein levels, as determined by immunoblots, were highest in full-sized green seed but the protein virtually disappeared in mature seed. However, amino acid analysis of mature seed, in the best transgenic line, showed a significant increase of 16.2 and 65.9 % in methionine and cysteine, respectively, as compared to the parent. This indicates that MB-16 elevated the sulfur amino acids, improved the EAA seed profile and confirms that a de novo synthetic gene can enhance the nutritional quality of soybean.

  2. Propane Canada's first ever auto propane conversion directory

    International Nuclear Information System (INIS)

    Anon.

    1999-01-01

    A directory of auto propane dealers in Alberta, British Columbia and Manitoba was presented. Dealers in Calgary, Edmonton, Burnaby, Dawson Creek and Winnipeg were listed along with their addresses, phone numbers, fax, and E-mail addresses. Some of the other information provided included accreditation, equipment used and manufacturer brands used by the dealers

  3. Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Yerly Vargas Casanova

    2017-09-01

    Full Text Available Linear, dimeric, tetrameric, and cyclic peptides derived from lactoferricin B, containing the RRWQWR motif, were designed, synthesized, purified, and characterized using RP-HPLC chromatography and MALDI-TOF mass spectrometry. The antibacterial activity of the designed peptides against E. coli (ATCC 11775 and 25922 and their cytotoxic effect against MDA-MB-468 and MDA-MB-231 breast cancer cell lines were evaluated. Dimeric and tetrameric peptides showed higher antibacterial activity in both bacteria strains than linear peptides. The dimeric peptide (RRWQWR2K-Ahx exhibited the highest antibacterial activity against the tested bacterial strains. Furthermore, the peptides with high antibacterial activity exhibited significant cytotoxic effect against the tested breast cancer cell lines. This cytotoxic effect was fast and dependent on the peptide concentration. The tetrameric molecule containing RRWQWR motif has an optimal cytotoxic effect at a concentration of 22 µM. The evaluated dimeric and tetrameric peptides could be considered as candidates for developing new therapeutic agents against breast cancer. Polyvalence of linear sequences could be considered as a novel and versatile strategy for obtaining molecules with high anticancer activity.

  4. Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines.

    Science.gov (United States)

    Vargas Casanova, Yerly; Rodríguez Guerra, Jorge Antonio; Umaña Pérez, Yadi Adriana; Leal Castro, Aura Lucía; Almanzar Reina, Giovanni; García Castañeda, Javier Eduardo; Rivera Monroy, Zuly Jenny

    2017-09-29

    Linear, dimeric, tetrameric, and cyclic peptides derived from lactoferricin B, containing the RRWQWR motif, were designed, synthesized, purified, and characterized using RP-HPLC chromatography and MALDI-TOF mass spectrometry. The antibacterial activity of the designed peptides against E. coli (ATCC 11775 and 25922) and their cytotoxic effect against MDA-MB-468 and MDA-MB-231 breast cancer cell lines were evaluated. Dimeric and tetrameric peptides showed higher antibacterial activity in both bacteria strains than linear peptides. The dimeric peptide (RRWQWR)₂K-Ahx exhibited the highest antibacterial activity against the tested bacterial strains. Furthermore, the peptides with high antibacterial activity exhibited significant cytotoxic effect against the tested breast cancer cell lines. This cytotoxic effect was fast and dependent on the peptide concentration. The tetrameric molecule containing RRWQWR motif has an optimal cytotoxic effect at a concentration of 22 µM. The evaluated dimeric and tetrameric peptides could be considered as candidates for developing new therapeutic agents against breast cancer. Polyvalence of linear sequences could be considered as a novel and versatile strategy for obtaining molecules with high anticancer activity.

  5. Aviation investigation report : hard landing : fuel leak and fire[Sundance Balloons International Firefly 12B (hot air balloon) C-FNVM, Winnipeg, Manitoba, 15 nm NE, 11 August 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-08-15

    This investigation report discussed an incident in Winnipeg in which a hot air balloon attempting to land during strong winds was dragged on its side for approximately 700 feet. The balloon's burners struck the ground as the balloon came to a stop, after which a propane leak occurred. An intense, uncontrolled fire ensued as balloon passengers were exiting from the partially-inverted basket. The pilot and 2 passengers suffered serious injuries, while another 4 passengers suffered minor injuries. The balloon's 2 propane tanks and a fire extinguisher canister exploded during the fire, which destroyed the balloon's basket. The rigging of the balloon was examined and no failures were discovered. Pressure tests showed that the balloon's hoses started leaking at the crimped sleeve fittings at 150 psi. While the pilot had been informed of potentially heavy winds and thunderstorms, changes in wind speed and direction occurred earlier than the forecasted time of 10:00. It was concluded that standards are needed to ensure balloon cabin safety. Balloon operators do not currently require the use of protective helmets or gloves in case of dragged landings. A review will be conducted to address the issue of proposed emergency fuel shut-offs for balloons carrying fare-paying passengers. 2 figs.

  6. Boehringer immunoinhibition procedure for creatine kinase-MB evaluated and compared with column ion-exchange chromatography

    NARCIS (Netherlands)

    ter Welle, H. F.; Baartscheer, T.; Fiolet, J. W.

    1983-01-01

    In determination of creatine kinase isoenzyme MB (CK-MB), the Boehringer immunoinhibition method gives a high and variable blank activity as compared with column-chromatography. Thus a correction must be applied. Furthermore, a second correction of 1% of total creatine kinase activity is necessary

  7. Transnational surrogacy: Canada's contradictions.

    Science.gov (United States)

    Lozanski, Kristin

    2015-01-01

    Transnational commercial surrogacy represents a form of medical tourism undertaken by intended parents who seek to hire women in other countries, increasingly often in the global South, as surrogates. While much of the scholarly literature focuses on the conditions of surrogacy within host countries, such as India, there has been limited analysis of transnational surrogacy focused upon origin countries. In this article, I build upon the scholarship that explores the impact of host country structures on transnational surrogacy, with special attention to the significance of Canadian citizenship policy through analysis of legislation and policy vis-à-vis transnational commercial surrogacy. The Canadian case demonstrates clear contradictions between the legislation and policy that is enacted domestically to prohibit commercial surrogacy within Canada and legislation and policy that implicitly sanctions commercial surrogacy through the straightforward provision of citizenship for children born of such arrangements abroad. The ethical underpinnings of Canada's domestic prohibition of commercial surrogacy, which is presumed to exploit women and children and to impede gender equality, are violated in Canada's bureaucratic willingness to accept children born of transnational commercial surrogacy as citizens. Thus, the ethical discourses apply only to Canadian citizens within Canadian geography. The failure of the Canadian government to hold Canadian citizens who participate in transnational commercial surrogacy to the normative imperatives that prohibit the practice within the country, or to undertake a more nuanced, and necessarily controversial, discussion of commercial surrogacy reinforces transnational disparities in terms of whose bodies may be commodified as a measure of gendered inequality. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Canada and international financial institutions

    OpenAIRE

    Robert Lafrance; James Powell

    1996-01-01

    International financial institutions, such as the International Monetary Fund, the World Bank and the Bank for International Settlements, are important players in the global financial system. This article provides an overview of the major international financial institutions to which Canada belongs. The paper highlights their activities and the nature of Canada's involvement, including that of the Bank of Canada. Recent initiatives coming out of the Halifax and Lyon Summits to improve the eff...

  9. Assisted Dying in Canada.

    Science.gov (United States)

    Schuklenk, Udo

    This paper makes an affirmative ethical case in favour of the decriminalization of assisted dying in Canada. It then proceeds to defending the affirmative case against various slippery-slope arguments that are typically deployed by opponents of assisted dying. Finally, a recent case of questionable professional conduct by anti-euthanasia campaigners cum academics is flagged as a warning to all of us not to permit the quality of the professional debate to deteriorate unacceptably, despite the personal emotional investments involved on all sides of the debate.

  10. Energy utilization in Canada

    International Nuclear Information System (INIS)

    Klassen, J.

    1976-04-01

    The situation of the energy supply of Canada is characterized by its geographic location and by the dispersal of the energy consumers over a wide area. At present, the energy supply leaving the successful CANDU nuclear energy programme out of account, is based mainly on crude oil, natural gas, and electricity as well as on coal imported from the USA. The targets of Canadian enery policies and energy research are stated as follows: a) Reducing and optimizing energy consumption, b) introducing district heating, and c) utilizing the extensive local coal deposits. (GG) [de

  11. Growth and enzymological characteristics of a pink-pigmented facultative methylotroph Methylobacterium sp. MB1.

    Science.gov (United States)

    Baev, M V; Kuznetsov, E V; Skladnev, D A; Govorukhina, N I; Sterkin, V E; Tsygankov, Y D

    1992-01-01

    Growth characteristics of batch and continuous cultures of the pink facultative methylotroph Methylobacterium sp. MB1 were determined. The response of a chemostat culture to a pulse increase of methanol concentration was studied. Malate, succinate and oxaloacetate additions to the methanol-supplemented medium decreased batch culture growth inhibition by methanol. The carotenoid content in cells grown in a chemostat decreased with increasing growth rate. The key enzyme activities of C1-metabolism were measured in a chemostat culture at different dilution rates.

  12. Mechanism of Binding to Ebola Virus Glycoprotein by the ZMapp, ZMAb, and MB-003 Cocktail Antibodies

    OpenAIRE

    Davidson, Edgar; Bryan, Christopher; Fong, Rachel H.; Barnes, Trevor; Pfaff, Jennifer M.; Mabila, Manu; Rucker, Joseph B.; Doranz, Benjamin J.

    2015-01-01

    Cocktails of monoclonal antibodies (MAbs) that target the surface glycoprotein (GP) of Ebola virus (EBOV) are effective in nonhuman primate models and have been used under emergency compassionate-treatment protocols in human patients. However, the amino acids that form the detailed binding epitopes for the MAbs in the ZMapp, ZMAb, and the related MB-003 cocktails have yet to be identified. Other binding properties that define how each MAb functionally interacts with GP—such as affinity, epito...

  13. Lambda-bar, lambda(1) and m(b) in three-flavor (lattice) QCD

    International Nuclear Information System (INIS)

    Freeland, Elizabeth D.; Art Inst. of Chicago; Kronfeld, Andreas S.; Simone, James N.; Van de Water, Ruth S.; Fermilab

    2006-01-01

    The heavy-quark expansion for inclusive semi-leptonic B decays introduces Λ and λ1 , which are matrix elements in heavy-quark effective field theory. We review how they can be obtained from an analysis of the heavy quark mass dependence of heavy-light meson masses in lattice QCD. We present preliminary results for the bottom quark mass, mb, using Λ and λ1 for the Bs meson from a 2+1 sea-flavor unquenched calculation

  14. Nutrition inequities in Canada.

    Science.gov (United States)

    Tarasuk, Valerie; Fitzpatrick, Sandra; Ward, Heather

    2010-04-01

    In Canada, increased morbidity and shorter life expectancy have been found among those with lower incomes and lower levels of education, but there has been little examination of socioeconomic variation in food and nutrient intake. Using data from the 2004 Canadian Community Health Survey, we examined the relationship between household income and education level and adults' and children's intakes of energy, fibre, micronutrients, and number of servings consumed of food groups from Canada's Food Guide. To explore the public health significance of observed associations, we estimated the prevalence of inadequacy for selected nutrients for adults, stratifying by household income, education level, and sex. We found that a higher household income adequacy and (or) higher levels of education were associated with increased consumption of milk and alternatives, and vegetables and fruit, and significantly higher vitamin, mineral, and fibre intakes among both adults and children. The prevalence of inadequate nutrient intakes among adults was higher among adults with the lowest level of income adequacy or educational attainment, compared with others. Our results suggest that the nutritional quality of Canadians' food intakes is, in part, a function of their social position. The impact of policy and program interventions needs to be examined across socioeconomic strata to ensure that actions reduce rather than exacerbate nutrition inequities.

  15. Energy in Canada

    International Nuclear Information System (INIS)

    Dixon, R.S.

    1980-12-01

    Canada's historical energy consumption, its current consumption and its likely requirements by the turn of the century are reviewed. It is estimated that at least 50% more energy will be required in the year 2000 than is consumed now, assuming a minimum 2% growth rate in primary energy consumption. Both non-renewable and renewable energy resources are examined in the light of these future energy requirements and the need to substitute alternative energy sources for conventional oil in various end uses. The comparative risks involved in energy production are also reviewed. Most of the increase in energy consumption and the substitution of oil over the next 20 years is likely to be met by conventional energy sources, since indigenous reserves are extensive and the relevant technologies well-established. Coal, nuclear and hydro reserves could cover the increase in energy demand until well into the next century, and natural gas reserves are sufficient to bridge the gap during conversion from oil to other energy sources. Nuclear power using advanced fuel cycles and oil from tar sands offer Canada long-term security. The penetration of unconventional energy sources is likely to be relatively small during the next 20 years. However, the most promising may become significant in the next century. (author)

  16. Wheeling in Canada

    International Nuclear Information System (INIS)

    Fytche, E.L.

    1991-01-01

    The quest for economic efficiency, or lowest cost, in the electricity supply industry is furthered by trading between high and low cost utilities, one aspect being transporting or wheeling power through the transmission system of a third party. Some of the pressures and constraints limiting wheeling are discussed. A simple formula is presented for determining whether trading and wheeling are worthwhile. It is demonstrated for assumed capital and operating cost levels, the viability of nine cases where bulk power or economy energy would need to be wheeled across provincial boundaries in order to reach potential buyers. Wheeling in Canada is different from the situation in the USA, due to large distances spanned by Canadian utilities and because most are provincial crown corporations, with different territorial interests and profit motivations than investor-owned utilities. Most trading in electricity has been between contiguous neighbours, for mutual advantage. New technology allows power transmission over distances of up to 1000 miles, and the economics of Canada's electrical supply could be improved, with means including access to low cost coal of Alberta, and remote hydro in British Columbia, Manitoba, Quebec and Labrador. Nuclear plants could be located anywhere but suffer from an unfriendly public attitude. A bridge across the Prairies appears uneconomic due to cost of transmission, and also due to low valuation given to Alberta coal. 7 refs., 2 figs., 3 tabs

  17. Canada's Clean Air Act

    International Nuclear Information System (INIS)

    2006-01-01

    This paper provided an outline of Canada's Clean Air Act and examined some of the regulatory changes that will occur as a result of its implementation. The Act is being introduced to strengthen the legislative basis for taking action on reducing air pollution and GHGs, and will allow the government to regulate both indoor and outdoor air pollutants and GHGs. The Act will require the Ministers of the Environment and Health to establish national air quality objectives, as well as to monitor and report on their attainment. The Canadian Environmental Protection Act will be amended to enable the government to regulate the blending of fuels and their components. The Motor Vehicle Fuel Consumption Standards Act will also be amended to enhance the government's authority to regulate vehicle fuel efficiency. The Energy Efficiency Act will also be expanded to allow the government to set energy efficiency standards and labelling requirements for a wider range of consumer and commercial products. The Act will commit to short, medium and long-term industrial air pollution targets. Regulations will be proposed for emissions from industry; on-road and off-road vehicles and engines; and consumer and commercial products. It was concluded that the Government of Canada will continue to consult with provinces, territories, industries and Canadians to set and reach targets for the reduction of both indoor and outdoor air pollutants and GHG emissions. 6 figs

  18. Detection of genomic variation by selection of a 9 mb DNA region and high throughput sequencing.

    Directory of Open Access Journals (Sweden)

    Sergey I Nikolaev

    Full Text Available Detection of the rare polymorphisms and causative mutations of genetic diseases in a targeted genomic area has become a major goal in order to understand genomic and phenotypic variability. We have interrogated repeat-masked regions of 8.9 Mb on human chromosomes 21 (7.8 Mb and 7 (1.1 Mb from an individual from the International HapMap Project (NA12872. We have optimized a method of genomic selection for high throughput sequencing. Microarray-based selection and sequencing resulted in 260-fold enrichment, with 41% of reads mapping to the target region. 83% of SNPs in the targeted region had at least 4-fold sequence coverage and 54% at least 15-fold. When assaying HapMap SNPs in NA12872, our sequence genotypes are 91.3% concordant in regions with coverage > or = 4-fold, and 97.9% concordant in regions with coverage > or = 15-fold. About 81% of the SNPs recovered with both thresholds are listed in dbSNP. We observed that regions with low sequence coverage occur in close proximity to low-complexity DNA. Validation experiments using Sanger sequencing were performed for 46 SNPs with 15-20 fold coverage, with a confirmation rate of 96%, suggesting that DNA selection provides an accurate and cost-effective method for identifying rare genomic variants.

  19. Protein Kinase G facilitates EGFR-mediated cell death in MDA-MB-468 cells

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, Nicole M.; Ceresa, Brian P., E-mail: brian.ceresa@louisville.edu

    2016-08-15

    The Epidermal Growth Factor Receptor (EGFR) is a transmembrane receptor tyrosine kinase with critical implications in cell proliferation, migration, wound healing and the regulation of apoptosis. However, the EGFR has been shown to be hyper-expressed in a number of human malignancies. The MDA-MB-468 metastatic breast cell line is one example of this. This particular cell line hyper-expresses the EGFR and undergoes EGFR-mediated apoptosis in response to EGF ligand. The goal of this study was to identify the kinases that could be potential intermediates for the EGFR-mediated induction of apoptosis intracellularly. After identifying Cyclic GMP-dependent Protein Kinase G (PKG) as a plausible intermediate, we wanted to determine the temporal relationship of these two proteins in the induction of apoptosis. We observed a dose-dependent decrease in MDA-MB-468 cell viability, which was co-incident with increased PKG activity as measured by VASPSer239 phosphorylation. In addition, we observed a dose dependent decrease in cell viability, as well as an increase in apoptosis, in response to two different PKG agonists, 8-Bromo-cGMP and 8-pCPT-cGMP. MDA-MB-468 cells with reduced PKG activity had attenuated EGFR-mediated apoptosis. These findings indicate that PKG does not induce cell death via transphosphorylation of the EGFR. Instead, PKG activity occurs following EGFR activation. Together, these data indicate PKG as an intermediary in EGFR-mediated cell death, likely via apoptotic pathway.

  20. Ground deformation monitoring using RADARSAT-2 DInSAR-MSBAS at the Aquistore CO2 storage site in Saskatchewan (Canada)

    Science.gov (United States)

    Czarnogorska, M.; Samsonov, S.; White, D.

    2014-11-01

    The research objectives of the Aquistore CO2 storage project are to design, adapt, and test non-seismic monitoring methods for measurement, and verification of CO2 storage, and to integrate data to determine subsurface fluid distributions, pressure changes and associated surface deformation. Aquistore site is located near Estevan in Southern Saskatchewan on the South flank of the Souris River and west of the Boundary Dam Power Station and the historical part of Estevan coal mine in southeastern Saskatchewan, Canada. Several monitoring techniques were employed in the study area including advanced satellite Differential Interferometric Synthetic Aperture Radar (DInSAR) technique, GPS, tiltmeters and piezometers. The targeted CO2 injection zones are within the Winnipeg and Deadwood formations located at > 3000 m depth. An array of monitoring techniques was employed in the study area including advanced satellite Differential Interferometric Synthetic Aperture Radar (DInSAR) with established corner reflectors, GPS, tiltmeters and piezometers stations. We used airborne LIDAR data for topographic phase estimation, and DInSAR product geocoding. Ground deformation maps have been calculated using Multidimensional Small Baseline Subset (MSBAS) methodology from 134 RADARSAT-2 images, from five different beams, acquired during 20120612-20140706. We computed and interpreted nine time series for selected places. MSBAS results indicate slow ground deformation up to 1 cm/year not related to CO2 injection but caused by various natural and anthropogenic causes.

  1. A 54 Mb 11qter duplication and 0.9 Mb 1q44 deletion in a child with laryngomalacia and agenesis of corpus callosum

    Directory of Open Access Journals (Sweden)

    Lall Meena

    2011-09-01

    Full Text Available Abstract Background Partial Trisomy 11q syndrome (or Duplication 11q has defined clinical features and is documented as a rare syndrome by National Organization of Rare Disorders (NORD. Deletion 1q44 (or Monosomy 1q44 is a well-defined syndrome, but there is controversy about the genes lying in 1q44 region, responsible for agenesis of the corpus callosum. We report a female child with the rare Partial Trisomy 11q syndrome and Deletion 1q44 syndrome. The genomic imbalance in the proband was used for molecular characterization of the critical genes in 1q44 region for agenesis of corpus callosum. Some genes in 11q14q25 may be responsible for laryngomalacia. Results We report a female child with dysmorphic features, microcephaly, growth retardation, seizures, acyanotic heart disease, and hand and foot deformities. She had agenesis of corpus callosum, laryngomalacia, anterior ectopic anus, esophageal reflux and respiratory distress. Chromosome analysis revealed a derivative chromosome 1. Her karyotype was 46,XX,der(1t(1;11(q44;q14pat. The mother had a normal karyotype and the karyotype of the father was 46,XY,t(1;11(q44;q14. SNP array analysis showed that the proband had a 54 Mb duplication of 11q14q25 and a 0.9 Mb deletion of the submicroscopic subtelomeric 1q44 region. Fluorescence Insitu Hybridisation confirmed the duplication of 11qter and deletion of 1qter. Conclusion Laryngomalacia or obstruction of the upper airway is the outcome of increased dosage of some genes due to Partial Trisomy 11q Syndrome. In association with other phenotypic features, agenesis of corpus callosum appears to be a landmark phenotype for Deletion 1q44 syndrome, the critical genes lying proximal to SMYD3 in 1q44 region.

  2. Canada's steps towards nuclear power

    International Nuclear Information System (INIS)

    Lewis, W.B.

    1958-09-01

    This paper describes the policy development of nuclear power in Canada. Canada has a natural abundance of coal, oil, natural gas, water power and uranium. It was recognized that the demand for nuclear power would only materialize if it met an economically competitive range.

  3. Radioactive waste management in Canada

    International Nuclear Information System (INIS)

    Hawley, N.J.

    1986-09-01

    This bibliography is an up-date to AECL-6186(Rev 3), 1952-1982, 'Radioactive Waste Management in Canada AECL Publications and Other Literature' compiled by Dianne Wallace. Canadian publications from outside contractors concerning the Canadian Nuclear Fuel Waste Management Program are included in addition to Atomic Energy of Canada Limited reports and papers. 252 refs

  4. ESPlannerBASIC CANADA

    Directory of Open Access Journals (Sweden)

    Laurence Kotlikoff

    2015-02-01

    Full Text Available Traditional financial planning is based on a fundamental rule of thumb: Aim to save enough for retirement to replace 80 per cent of your pre-retirement income with income from pensions and assets. Millions of Canadians follow this formula. Yet, there is no guarantee this approach is consistent with a savings plan that will allow them to experience their optimal standard of living — given their income — throughout their working lives. Consumption smoothing happens when a consumer projects her income and her non-discretionary expenses (such as mortgage payments all the way up until the end of her life, and is able to determine her household discretionary spending power over time, to achieve the smoothest living standard path possible without going into debt. When consumption smoothing is calculated accurately, a person’s lifestyle should be roughly the same whether she is in her 30s with small children, in her 50s with kids in college, or in retirement, with adult children. Consumption smoothing allows that to happen. But while it is conceptually straightforward, consumption smoothing requires the use of advanced numerical techniques. Now, Canadian families have access to a powerful consumption-smoothing tool: ESPlannerBASIC Canada. This free, secure and confidential online tool will allow Canadian families to safely and securely enter their earnings and other financial resources and will calculate for them how much they can spend and how much they should save in order to maintain their lifestyle from now until they die, without going into debt. It will also calculate how much life insurance they should buy, to ensure that household living standards are not affected after a family member dies. Users can easily and instantly run “what-if” scenarios to see how retiring early (or later, changing jobs, adjusting retirement contributions, having children, moving homes, timing RRSP withdrawals, and other financial and lifestyle decisions would

  5. Energy in Canada 2000

    International Nuclear Information System (INIS)

    2000-01-01

    This publication provides a panoramic overview of Canada's energy situation at the beginning of the 21st century, presenting the issues that drive the country's energy policy, and a look at the various technologies by which energy is produced, its sources, transformation and the infrastructure required to deliver it to the consumer. Energy consumption by sectors of the economy, energy conservation and energy conservation issues are analyzed, and details of the lines of actions designed by the federal government to achieve its energy policy objectives are explained. Appendix One provides more detail on the complex issue of climate change, while Appendix Two provides some energy-related statistics, extracted from a database of energy statistics which are also available in graphic or spreadsheet format at http://www.nrcan.gc.ca/es/ener2000. 12 tabs., 40 figs

  6. Tritium activities in Canada

    International Nuclear Information System (INIS)

    Gierszewski, P.

    1995-01-01

    Canadian tritium activites comprise three major interests: utilites, light manufacturers, and fusion. There are 21 operating CANDU reactors in Canada; 19 with Ontario Hydro and one each with Hydro Quebec and New Brunswick Power. There are two light manufacturers, two primary tritium research facilities (at AECL Chalk River and Ontario Hydro Technologies), and a number of industry and universities involved in design, construction, and general support of the other tritium activities. The largest tritum program is in support of the CANDU reactors, which generate tritium in the heavy water as a by-product of normal operation. Currently, there are about 12 kg of tritium locked up in the heavy water coolant and moderator of these reactors. The fusion work is complementary to the light manufacturing, and is concerned with tritium handling for the ITER program. This included design, development and application of technologies related to Isotope Separation, tritium handling, (tritiated) gas separation, tritium-materials interaction, and plasma fueling

  7. Western Canada uranium perspective

    International Nuclear Information System (INIS)

    Lloyd, R.E.

    1984-01-01

    The current situation in the exploration for uranium in British Columbia, the Yukon, the Northwest Territories, and Saskatchewan is reviewed. A moratorium on exploration has been in effect in British Columbia since 1980; it is due to expire in 1987. Only the Blizzard deposit appears to have any economic potential. The Lone Gull discovery in the Thelon Basin of the Northwest Territories has proven reserves of more than 35 million pounds U 3 O 8 grading 0.4%. Potentially prospective areas of the northern Thelon Basin lie within a game sanctuary and cannot be explored. Exploration activity in Saskatchewan continues to decline from the peak in 1980. Three major deposits - Cluff Lake, Rabbit Lake and Key Lake - are in production. By 1985 Saskatchewan will produce 58% of Canada's uranium, and over 13% of the western world's output. (L.L.) (3 figs, 2 tabs.)

  8. Canada: Health system review.

    Science.gov (United States)

    Marchildon, Gregory

    2013-01-01

    Canada is a high-income country with a population of 33 million people. Its economic performance has been solid despite the recession that began in 2008. Life expectancy in Canada continues to rise and is high compared with most OECD countries; however, infant and maternal mortality rates tend to be worse than in countries such as Australia, France and Sweden. About 70% of total health expenditure comes from the general tax revenues of the federal, provincial and territorial governments. Most public revenues for health are used to provide universal medicare (medically necessary hospital and physician services that are free at the point of service for residents) and to subsidise the costs of outpatient prescription drugs and long-term care. Health care costs continue to grow at a faster rate than the economy and government revenue, largely driven by spending on prescription drugs. In the last five years, however, growth rates in pharmaceutical spending have been matched by hospital spending and overtaken by physician spending, mainly due to increased provider remuneration. The governance, organization and delivery of health services is highly decentralized, with the provinces and territories responsible for administering medicare and planning health services. In the last ten years there have been no major pan-Canadian health reform initiatives but individual provinces and territories have focused on reorganizing or fine tuning their regional health systems and improving the quality, timeliness and patient experience of primary, acute and chronic care. The medicare system has been effective in providing Canadians with financial protection against hospital and physician costs. However, the narrow scope of services covered under medicare has produced important gaps in coverage and equitable access may be a challenge in these areas. World Health Organization 2013 (acting as the host organization for, and secretariat of, the European Observatory on Health Systems and

  9. Clinician-scientist MB/PhD training in the UK: a nationwide survey of medical school policy.

    Science.gov (United States)

    Barnett-Vanes, Ashton; Ho, Guiyi; Cox, Timothy M

    2015-12-30

    This study surveyed all UK medical schools regarding their Bachelor of Medicine (MB), Doctor of Philosophy (PhD) (MB/PhD) training policy in order to map the current training landscape and to provide evidence for further research and policy development. Deans of all UK medical schools registered with the Medical Schools Council were invited to participate in this survey electronically. The number of medical schools that operate institutional MB/PhD programmes or permit self-directed student PhD intercalation. Medical school recruitment procedures and attitudes to policy guidance. 27 of 33 (81%) registered UK medical schools responded. Four (14%) offer an institutional MB/PhD programme. However, of those without institutional programmes, 17 (73%) permit study interruption and PhD intercalation: two do not (one of whom had discontinued their programme in 2013), three were unsure and one failed to answer the question. Regarding student eligibility, respondents cited high academic achievement in medical studies and a bachelor's or master's degree. Of the Medical schools without institutional MB/PhD programmes, 5 (21%) have intentions to establish a programme, 8 (34%) do not and 3 were unsure, seven did not answer. 19 medical schools (70%) considered national guidelines are needed for future MB/PhD programme development. We report the first national survey of MB/PhD training in the UK. Four medical schools have operational institutional MB/PhD programmes, with a further five intending to establish one. Most medical schools permit study interruption and PhD intercalation. The total number MB/PhD students yet to graduate from medical school could exceed 150, with 30 graduating per year. A majority of medical school respondents to this survey believe national guidelines are required for MB/PhD programme development and implementation. Further research should focus on the MB/PhD student experience. Discussion regarding local and national MB/PhD policies between medical

  10. Canada`s green plan - The second year. Summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    Canada`s Green Plan is the national strategy and action plan for sustainable development launched by the federal government. The Green Plan`s goal is `to secure for current and future generations a safe and healthy environment and a sound and prosperous economy.` It represents a fundamental shift in the way the federal government views economic development and environmental protection: they are inextricably linked; both are critical to the health and well-being of Canadians. Substantial development has been made in Canada, with advances being made on the Green Plan`s short-term objectives and on our longer term priorities.

  11. Protein synthesis rate measured with l-[1-11C]tyrosine positron emission tomography correlates with mitotic activity and MIB-1 antibody-detected proliferation in human soft tissue sarcomas

    International Nuclear Information System (INIS)

    Plaat, B.; Mastik, M.; Molenaar, W.; Kole, A.; Vaalburg, W.; Hoekstra, H.

    1999-01-01

    Protein synthesis rate (PSR) can be assessed in vivo using positron emission tomography with l-[1- 11 C]tyrosine (TYR-PET). Biological activity of soft tissue sarcomas (STS) can be measured in vitro by the mitotic rate and number of proliferating cells. In STS the grade of malignancy, in which the mitotic index plays a major role, is considered to be the major standard in predicting biological tumour behaviour. This study was designed to test the validity of TYR-PET in relation to different histopathological features. In 21 patients with untreated STS, the PSR was measured using TYR-PET. The number of mitoses was counted and tumours were graded according to the grading system of Coindre et al. (Cancer 1986; 58:306-309). Proliferative activity was assessed by immunohistological detection of the Ki-67 nuclear antigen using MIB-1 monoclonal antibody. To test the association between the PSR and these tumour parameters, a correlation analysis was performed. A significant (P<0.05) correlation was found between PSR and the Ki-67 proliferation index (R = 0.54), and between PSR and mitotic rate (R = 0.64). There was no correlation between PSR and tumour grade. The present study in malignant soft tissue tumours relates in vivo tumour metabolism as established with TYR-PET to tumour activity measured in vitro and indicates that the non-invasive method of TYR-PET can estimate the mitotic and proliferative activity in STS. (orig.)

  12. Canada No. 1 in business

    International Nuclear Information System (INIS)

    Poulsen, Henning

    2004-01-01

    Canada has for the fifth time in a row been chosen the best industrialized country in the world in which to initiate and run a business. The Norwegian interest in Canada has grown strongly the last years and Norwegian companies have invested over 20 billion NOK there. Canada is the perfect gateway to the large markets in the USA. Norway is currently Canada's 15th largest trading partner. In addition to low costs and strategic location, Canada has the most highly educated workforce in the world. A company on the Canadian side of the US border has the same access to the American market as a US-based company. There is even a Norwegian company in Canada that exports 100 per cent of its products across the border to the USA. The trade between the USA and Canada is more extensive than between the USA and all the EU countries together. Furthermore, Canadian companies concentrating on research and education are given a generous tax credit

  13. Determination of buckling in the IPEN/MB-01 Reactor in cylindrical configuration

    Energy Technology Data Exchange (ETDEWEB)

    Purgato, Rafael Turrini; Bitelli, Ulysses d' Utra; Aredes, Vitor Ottoni; Silva, Alexandre F. Povoa da; Santos, Diogo Feliciano dos; Mura, Luis Felipe L.; Jerez, Rogerio, E-mail: rtpurgato@ipen.br, E-mail: ubitelli@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    One of the key parameters in reactor physics is the buckling of a reactor core. It is related to important parameters such as reaction rates, nuclear power operation, fuel burning, among others. In a critical reactor, the buckling depends on the geometric and material characteristics of the reactor core. This paper presents the results of experimental buckling in the reactor IPEN/MB-01 nuclear reactor in its cylindrical configuration with 28 fuel rods along its diameter. The IPEN/MB-01 is a zero power reactor designed to operate at a maximum power of 100 watts, it is a versatile nuclear facility which allows the simulation of all the characteristics of a large nuclear power reactor and ideal for this type of measurement. We conducted a mapping of neutron flux inside the reactor and thereby determined the total buckling of the cylindrical configuration. The reactor was operated for an hour. Then, the activation of the fuel rods was measured by gamma spectrometry on a rod scanner HPGe detector. We analyzed the gamma photons of the {sup 239}Np (276,6 keV) for neutron capture and the {sup 143}Ce (293,3 keV) for fission on both {sup 238}U and {sup 235}U, respectively. We analyzed the axial and radial directions. Other measurements were performed using wires and gold foils in the radial and axial directions of the reactor core. The results showed that the cylindrical configuration compared to standard rectangular configuration of the IPEN/MB-01 reactor has a higher neutron economy, since in this configuration there is less leakage of neutrons. The Buckling Total obtained from the three methods was 95.84 ± 2.67 m{sup -2}. (author)

  14. Performance evaluation of a chemiluminescence microparticle immunoassay for CK-MB.

    Science.gov (United States)

    Lin, Zhi-Yuan; Fang, Yi-Zhen; Jin, Hong-Wei; Lin, Hua-Yue; Dai, Zhang; Luo, Qing; Li, Hong-Wei; Lin, Yan-Ling; Huang, Shui-Zhen; Gao, Lei; Xu, Fei-Hai; Zhang, Zhong-Ying

    2018-03-31

    To verify and evaluate the performance characteristics of a creatine kinase phosphokinase isoenzymes MB (CK-MB) assay kit, which produced by Xiamen Innodx Biotech Co. Ltd. Evaluation was carried out according to "Guidelines for principle of analysis performance evaluation of in vitro diagnostic reagent." The performance parameters included detection limit, linearity range, reportable range, recovery test, precision verification, interference test, cross-reactivity, matrix effect, and method comparison. The detection limit was 0.1 ng/mL. The assay had clinical linearity over range of 0.1 ng/mL-500 ng/mL. Reportable range was from 0.1 ng/mL to 1000 ng/mL. The average percent of recovery was 99.66%. The coefficient of variation (CV) for within-run and between-run of low CK-MB sample was 5.55% and 6.16%, respectively. As for high-level sample, it was 7.88% and 7.80%. In medical decision level, the relative deviation (Bias) of all interference tests was lower than 15%. When the sample had mild-hemolysis; hemoglobin ≤15 g/L; triglyceride ≤17 mmol/L; bilirubin ≤427.5 μmol/L; rheumatoid factor ≤206U/mL, there was no significant interference to be found. Moreover, assay kit had no cross-reaction with CK-MM and CK-BB. At last, total diagnostic accuracy of kit was 93.24%, when compared with refer kit. Overall the results of the verification study indicated the performance of kit is met the requirements of the clinical test. © 2018 Wiley Periodicals, Inc.

  15. Suspected resistance of MDT-MB in Multibacillary Leprosy of Hansen's disease: Two case reports

    Directory of Open Access Journals (Sweden)

    Yudo Irawan

    2016-12-01

    Full Text Available Resistance to multidrug therapy (MDT is one of the complications in the treatment of Hansen’s disease/Morbus Hansen (MH. There are two types of resistancy, which are primary and secondary. MDT-multibacillary (MB resistance must be suspected when no clinical improvement and the acid-fast bacilli (AFB index is not reduced after 12 months of therapy. A 28-year-old woman with paresthesia on her face, arms and legs since 2.5 years ago, accompanied by thickening of the right posterior tibial nerve. The AFB examination showed a bacteriological index (BI of 15/6 and morphological index (MI of 0.50%. The second case, a 42-year-old man came with paresthetic lesions on his face, chest, back, both arms and legs since 2 years ago, accompanied by thickening of ulnar and lateral peroneal nerve. The BI was 12/5 and the MI was 0.40%. Both patients were diagnosed with borderline lepromatous type of MH and received MDT-MB for 12 months. Diagnosis of suspected resistance was established because no clinical improvement or any significant decrease of AFB index after completing the MDT treatment. The patients had secondary resistance after polymerase chain reaction evaluation showed that they were still rifampicin-sensitive. There was clinical improvement and significant decrease in FAB index after the patients continued the MDT-MB treatment with 600 mg additional rifampicin. The diagnosis of bacterial resistance should be made based on clinical evaluation before completion of treatment. Based on the two case reports, the resistance suspected may be secondary. Treatment using additional regimen can be initiated once the resistance has been proven.

  16. Hexabromocyclododecane (HBCDD) Flame Retardant in Top Predator Fish across Canada and its 36-Year Temporal Trends for Lake Ontario.

    Science.gov (United States)

    Su, Guanyong; McGoldrick, Daryl; Clark, Mandi G; Evans, Marlene; Gledhill, Melissa; Garron, Christine; Armellin, Alain; Backus, Sean; Letcher, Robert J

    2018-05-08

    Hexabromocyclododecane (HBCDD) is a high concern environmental pollutant due to its persistent, bioaccumulative and toxic properties. The spatial distribution of HBCDD was investigated in top predator fish (Lake Trout, Walleye or Brook Trout) collected in 2013 (n=165) from nineteen sampling sites and in 2015 (n=145) from twenty sites across Canada. HBCDD was measurable in at least one sample at each sampling site regardless of sampling year with the exception of Walleye from the south basin of Lake Winnipeg (2013). Sampling sites in or near the Laurentian Great Lakes had greater HBCDD concentrations compared to locations to the west or east. The greatest mean HBCDD concentration was 72.6 ng/g lw in fish from Lake Huron-Goderich (2015). Regardless of the sampling sites, α-HBCDD was the dominant congener followed by γ-HBCDD, whereas β-HBCDD was barely detectable. In fish from the same waterbody there were comparable α/γ isomer concentration ratios. The greatest ratio was 20.8 in fish from Lake Ontario, whereas the lowest ratio was 6.3 for fish from Lac Memphrémagog (Québec) likely related to more recent emissions of technical HBCDD mixture. Temporal trends of HBCDD in Lake Trout from Lake Ontario showed a significant decreasing trend for γ-HBCDD with a half-life estimate of 10 years over a 36-year period (1979-2015), and for -HBCDD with a half-life of 11 years over the years of 2008 to 2015. The proportion of α-HBCDD to ΣHBCDD increased significantly during 1979 to 2015. The present study provided novel information on the isomer-specific HBCDDs in Canada freshwater fish.

  17. The MB2 gene family of Plasmodium species has a unique combination of S1 and GTP-binding domains

    Directory of Open Access Journals (Sweden)

    Ogunjumo Oluwasanmi

    2004-06-01

    Full Text Available Abstract Background Identification and characterization of novel Plasmodium gene families is necessary for developing new anti-malarial therapeutics. The products of the Plasmodium falciparum gene, MB2, were shown previously to have a stage-specific pattern of subcellular localization and proteolytic processing. Results Genes homologous to MB2 were identified in five additional parasite species, P. knowlesi, P. gallinaceum, P. berghei, P. yoelii, and P. chabaudi. Sequence comparisons among the MB2 gene products reveal amino acid conservation of structural features, including putative S1 and GTP-binding domains, and putative signal peptides and nuclear localization signals. Conclusions The combination of domains is unique to this gene family and indicates that MB2 genes comprise a novel family and therefore may be a good target for drug development.

  18. The MB2 gene family of Plasmodium species has a unique combination of S1 and GTP-binding domains

    Science.gov (United States)

    Romero, Lisa C; Nguyen, Thanh V; Deville, Benoit; Ogunjumo, Oluwasanmi; James, Anthony A

    2004-01-01

    Background Identification and characterization of novel Plasmodium gene families is necessary for developing new anti-malarial therapeutics. The products of the Plasmodium falciparum gene, MB2, were shown previously to have a stage-specific pattern of subcellular localization and proteolytic processing. Results Genes homologous to MB2 were identified in five additional parasite species, P. knowlesi, P. gallinaceum, P. berghei, P. yoelii, and P. chabaudi. Sequence comparisons among the MB2 gene products reveal amino acid conservation of structural features, including putative S1 and GTP-binding domains, and putative signal peptides and nuclear localization signals. Conclusions The combination of domains is unique to this gene family and indicates that MB2 genes comprise a novel family and therefore may be a good target for drug development. PMID:15222903

  19. Study on the isothermal forging process of MB26 magnesium alloy adaptor

    Directory of Open Access Journals (Sweden)

    Xu Wenchen

    2015-01-01

    Full Text Available The isothermal forging process is an effective method to manufacture complex-shaped components of hard-to-work materials, such as magnesium alloys. This study investigates the isothermal forging process of an MB26 magnesium alloy adaptor with three branches. The results show that two-step forging process is appropriate to form the adaptor forging, which not only improves the filling quality but also reduces the forging load compared with one-step forging process. Moreover, the flow line is distributed along the contour of the complex-shaped adaptor forging.

  20. Analysis of the IPEN/MB-01 critical unit based on criticality experiments

    International Nuclear Information System (INIS)

    Santos, Adimir dos; Yamaguchi, Mitsuo; Ferreira, Carlos Roberto; Yoriyaz, Helio

    1995-01-01

    The analysis of the critical loading of the IPEN/MB-01 was performed by using several reactor cell methodologies. The results obtained by using the coupled NJOY/AMPX-II/HAMMER-TECHNION shows the good quality of the available nuclear data files as well as the methodologies in the Reactor Physics area. The original HAMMER system shows results that are well as the methodologies in the Reactor Physics area. The original HAMMER system shows results that are well outside of the desired quality for a cell code. (author), 15 refs, 3 figs, 5 tabs

  1. The two conformers of acetanilide unraveled using LA-MB-FTMW spectroscopy

    Science.gov (United States)

    Cabezas, C.; Varela, M.; Caminati, W.; Mata, S.; López, J. C.; Alonso, J. L.

    2011-07-01

    Acetanilide has been investigated by laser ablation molecular beam Fourier transform microwave LA-MB-FTMW spectroscopy. The rotational spectrum of both trans and cis conformers have been analyzed to determine the rotational and 14N quadrupole coupling the constants. The spectrum of the less abundant cis conformer has been assigned for the first time. The doublets observed for this conformer have been interpreted in terms of the tunneling motion between two equivalent non-planar conformations through a small barrier in which the acetamide group and phenyl ring plane are perpendicular. The results are compared with those of the related formanilide.

  2. Synergistic action of cisplatin and echistatin in MDA-MB-231 breast cancer cells.

    Science.gov (United States)

    Czarnomysy, Robert; Surażyński, Arkadiusz; Popławska, Bożena; Rysiak, Edyta; Pawłowska, Natalia; Czajkowska, Anna; Bielawski, Krzysztof; Bielawska, Anna

    2017-03-01

    The aim of our study was to determine whether the use of cisplatin in the presence echistatin in MDA-MB-231 breast cancer cells leads to a reduction of toxic effects associated with the use of cisplatin. The expression of β 1 -integrin and insulin-like growth factor 1 receptor (IGF-IR), signaling pathway protein expression: protein kinase B (AKT), mitogen-activated protein kinases (ERK1/ERK2), nuclear factor kappa B (NFκB), and caspase-3 and -9 activity was measured after 24 h of incubation with tested compounds to explain detailed molecular mechanism of induction of apoptosis. The viability of MDA-MB-231 breast cancer cells was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Annexin V-FITC/propidium iodide staining assay was performed to detect the induction of apoptosis. Inhibition DNA biosynthesis was determined by [ 3 H]thymidine incorporation into DNA. The expression of of β 1 -integrin, IGF-IR, AKT, ERK1/ERK2, NFκB, caspase-3 and -9 was evaluated using Western blot. The results suggest that treatment of MDA-MB-231 breast cancer cells for 24 h cisplatin plus echistatin severely inhibits cell growth and activates apoptosis by upregulation of caspase-3 and -9 expressions. The effect was stronger than treatment cisplatin and echistatin alone. In this study, we have found that cisplatin plus echistatin treatment decreases collagen biosynthesis in MDA-MB-231 breast cancer cells stronger than the individual compounds. The inhibition was found to be dependent on the β 1 -integrin and IGF receptor activation. A significant reduction of ERK1/ERK2, AKT expression in cancer cells after cisplatin plus echistatin treatment was also found. The cancer cells treated by echistatin, cisplatin, and in particular the combination of both compounds drastically increased expression of NFκB transcription factor. Our results suggest that combined therapy cisplatin plus echistatin is a possible way to improve selectiveness of cisplatin. This

  3. The fast neutron SEU cross section of a 4 Mb SRAM memory

    International Nuclear Information System (INIS)

    Pereira Junior, Evaldo C.F.; Goncalez, Odair L.; Cruz, Marco Aurelio da; Prado, Adriane Cristina Mendes; Federico, Claudio Antonio; Gaspar, Felipe de Barros

    2013-01-01

    The results of a static test of single event upset (SEU) produced by fast neutrons on an ISSI 4Mb SRAM memory are reported in this work. To perform the tests, it was built a platform based on a motherboard which is controlled by microprocessor, whose function is to perform the writing, reading and control of the memories under irradiation. The irradiation was performed with a set of 8 241 Am-Be neutrons source in a quasi-isotropic incidence. The SEU cross was calculated from the accumulated bit flip count. (author)

  4. The effects of prior calcium channel blocker therapy on creatine kinase-MB levels after percutaneous coronary interventions

    OpenAIRE

    Gulmez, Oyku

    2008-01-01

    Oyku Gulmez, Ilyas Atar, Bülent Ozin, Mehmet Emin Korkmaz, Aslı Atar, Alp Aydinalp, Aylin Yildirir, Haldun MuderrisogluBaskent University Faculty of Medicine, Department of Cardiology, Ankara, TurkeyBackground: Use of intracoronary calcium channel blockers (CCBs) during percutaneous coronary intervention (PCI) has been shown to have favorable effects on coronary blood flow. We aimed to investigate the effects of CCBs administrated perorally on creatine kinase-MB (CK-MB) levels in pa...

  5. The effects of prior calcium channel blocker therapy on creatine kinase-MB levels after percutaneous coronary interventions

    OpenAIRE

    Oyku Gulmez; Ilyas Atar; Bülent Ozin; Mehmet Emin Korkmaz; Asli Atar; et al

    2008-01-01

    Oyku Gulmez, Ilyas Atar, Bülent Ozin, Mehmet Emin Korkmaz, Asli Atar, Alp Aydinalp, Aylin Yildirir, Haldun MuderrisogluBaskent University Faculty of Medicine, Department of Cardiology, Ankara, TurkeyBackground: Use of intracoronary calcium channel blockers (CCBs) during percutaneous coronary intervention (PCI) has been shown to have favorable effects on coronary blood flow. We aimed to investigate the effects of CCBs administrated perorally on creatine kinase-MB (CK-MB) levels in pat...

  6. Wellons Canada energy systems

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    Wellons Canada is a British Columbia-based company that specializes in the manufacture and installation of lumber drying and energy conversion equipment. This brochure provided details of the Wellons energy system designed for oriented strand board (OSB) plants. The brochure outlined the system's scope of supply, and provided illustrations of system procedures from the initial wet fuel bin through to the electric precipitator used for air clean-up. During the process, fuel was conveyed from the bin to metering bins into combustors and through a cyclo-blast cell. Forced draft fan systems were then used to provide primary and secondary combustion air. Radiant heaters were then used. A drop-out chamber was supplied to allow for complete combustion of fuel particles and to provide a drop-out of ash. A fan was then used to deliver diluent air to maintain the set point temperature in the hot gas stream. Refractory lined hot gas ducts were used to deliver heat to the dryers. Hot gas was then drawn through a multi-cyclone collector for ash removal. Electrostatic precipitators were used to clean up emissions on a continuous operating basis. An automatic system was used to collect ash from the combustion system grates and other areas. Details of installation services provided by the company were also included. 42 figs.

  7. The nuclear industry in Canada

    International Nuclear Information System (INIS)

    Anderson, D.; Broughton, W.

    1992-01-01

    The nuclear industry in Canada comprises three identifiable groups: (1) Atomic Energy of Canada Limited (AECL), (2) electrical utilities that use nuclear power plants, (3) private engineering and manufacturing companies. At the end of World War II, AECL was charged with investigating and developing peaceful uses of atomic power. Included in the results is the Canada deuterium uranium (CANDU) reactor, a peculiarly Canadian design. The AECL maintains research capability and operates as the prime nuclear steam supply system supplier. Utilities in three Canadian provinces operate nuclear power plants, New Brunswick, Quebec, and Ontario, with the majority in Ontario. From the beginning of the nuclear program in Canada, private industry has been an important partner to AECL and the utilities, filling roles as manufacturing subcontractors and as component designers. The prime objective of this paper is to illuminate the role of private industry in developing and maintaining a competitive world-class nuclear industry

  8. Canada-U.S. Relations

    National Research Council Canada - National Science Library

    Ek, Carl; Fergusson, Ian F; Nunez-Neto, Blas; Clarke, Stephen F; Abel, Amy; Becker, Geoffrey S; Buck, Eugene H; Corn, M. L; Gelb, Bernard A; Gorte, Ross W

    2006-01-01

    .... The early 1990s brought new governments to Ottawa and Washington, and although Canada's Liberal Party emphasized its determination to act independently of the United States when necessary, relations...

  9. FPGA BASED ASYNCHRONOUS PIPELINED MB-OFDM UWB TRANSMITTER BACKEND MODULES

    Directory of Open Access Journals (Sweden)

    M. Santhi

    2010-03-01

    Full Text Available In this paper, a novel scheme is proposed which comprises the advantages of asynchronous pipelining techniques and the advantages of FPGAs for implementing a 200Mbps MB-OFDM UWB transmitter digital backend modules. In asynchronous pipelined system, registers are used as in synchronous system. But they are controlled by handshaking signals. Since FPGAs are rich in registers, design and implementation of asynchronous pipelined MBOFDM UWB transmitter on FPGA using four-phase bundled-data protocol is considered in this paper. Novel ideas have also been proposed for designing asynchronous OFDM using Modified Radix-24 SDF and asynchronous interleaver using two RAM banks. Implementation has been performed on ALTERA STRATIX II EP2S60F1020C4 FPGA and it is operating at a speed of 350MHz. It is assured that the proposed MB-OFDM UWB system can be made to work on STRATIX III device with the operating frequency of 528MHz in compliance to the ECMA-368 standard. The proposed scheme is also applicable for FPGA from other vendors and ASIC.

  10. Experimental estimation of moderator temperature coefficient of reactivity of the IPEN/MB-01 research reactor

    International Nuclear Information System (INIS)

    Silva, Rubens C. da; Bitelli, Ulysses D.; Mura, Luiz Ernesto C.

    2017-01-01

    The aim of this article is to present the procedure for the experimental estimation of the Moderator Temperature Coefficient of Reactivity of the IPEN/MB-01 Research Reactor, a parameter that has an important role in the physics and the control operations of any reactor facility. At the experiment, the IPEN/MB-01 reactor went critical at the power of 1W (1% of its total power), and whose core configuration was 28 x 26 rectangular array of UO_2 fuel rods, inside a light water (moderator) tank. In addition, there was a heavy water (D_2O) reflector installed in the West side of the core to obtain an adequate neutron reflection along the experiment. The moderator temperature was increased in steps of 4 °C, and the measurement of the mean moderator temperature was acquired using twelve calibrated thermocouples, placed around the reactor core. As a result, the mean value of -4.81 pcm/°C was obtained for such coefficient. The curves of ρ(T) (Reactivity x Temperature) and α"M_T(T)(Moderator Temperature Coefficient of Reactivity x Temperature) were developed using data from an experimental measurement of the integral reactivity curves through the Stable Period and Inverse Kinetics Methods, that was carried out at the reactor with the same core configuration. Such curves were compared and showed a very similar behavior between them. (author)

  11. Experimental estimation of moderator temperature coefficient of reactivity of the IPEN/MB-01 research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Rubens C. da; Bitelli, Ulysses D.; Mura, Luiz Ernesto C., E-mail: rubensrcs@usp.br, E-mail: ubitelli@ipen.br, E-mail: credidiomura@gmail.com [Universidade de Sao Paulo (PNV/POLI/USP), SP (Brazil). Arquitetura Naval e Departamento de Engenharia Oceanica; Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2017-07-01

    The aim of this article is to present the procedure for the experimental estimation of the Moderator Temperature Coefficient of Reactivity of the IPEN/MB-01 Research Reactor, a parameter that has an important role in the physics and the control operations of any reactor facility. At the experiment, the IPEN/MB-01 reactor went critical at the power of 1W (1% of its total power), and whose core configuration was 28 x 26 rectangular array of UO{sub 2} fuel rods, inside a light water (moderator) tank. In addition, there was a heavy water (D{sub 2}O) reflector installed in the West side of the core to obtain an adequate neutron reflection along the experiment. The moderator temperature was increased in steps of 4 °C, and the measurement of the mean moderator temperature was acquired using twelve calibrated thermocouples, placed around the reactor core. As a result, the mean value of -4.81 pcm/°C was obtained for such coefficient. The curves of ρ(T) (Reactivity x Temperature) and α{sup M}{sub T}(T)(Moderator Temperature Coefficient of Reactivity x Temperature) were developed using data from an experimental measurement of the integral reactivity curves through the Stable Period and Inverse Kinetics Methods, that was carried out at the reactor with the same core configuration. Such curves were compared and showed a very similar behavior between them. (author)

  12. Hazardous Traffic Event Detection Using Markov Blanket and Sequential Minimal Optimization (MB-SMO

    Directory of Open Access Journals (Sweden)

    Lixin Yan

    2016-07-01

    Full Text Available The ability to identify hazardous traffic events is already considered as one of the most effective solutions for reducing the occurrence of crashes. Only certain particular hazardous traffic events have been studied in previous studies, which were mainly based on dedicated video stream data and GPS data. The objective of this study is twofold: (1 the Markov blanket (MB algorithm is employed to extract the main factors associated with hazardous traffic events; (2 a model is developed to identify hazardous traffic event using driving characteristics, vehicle trajectory, and vehicle position data. Twenty-two licensed drivers were recruited to carry out a natural driving experiment in Wuhan, China, and multi-sensor information data were collected for different types of traffic events. The results indicated that a vehicle’s speed, the standard deviation of speed, the standard deviation of skin conductance, the standard deviation of brake pressure, turn signal, the acceleration of steering, the standard deviation of acceleration, and the acceleration in Z (G have significant influences on hazardous traffic events. The sequential minimal optimization (SMO algorithm was adopted to build the identification model, and the accuracy of prediction was higher than 86%. Moreover, compared with other detection algorithms, the MB-SMO algorithm was ranked best in terms of the prediction accuracy. The conclusions can provide reference evidence for the development of dangerous situation warning products and the design of intelligent vehicles.

  13. MB-OFDM-UWB Based Wireless Multimedia Sensor Networks for Underground Coalmine: A Survey.

    Science.gov (United States)

    Han, Ruisong; Yang, Wei; You, Kaiming

    2016-12-16

    Safety production of coalmines is a task of top priority which plays an important role in guaranteeing, supporting and promoting the continuous development of the coal industry. Since traditional wireless sensor networks (WSNs) cannot fully meet the requirements of comprehensive environment monitoring of underground coalmines, wireless multimedia sensor networks (WMSNs), enabling the retrieval of multimedia information, are introduced to realize fine-grained and precise environment surveillance. In this paper, a framework for designing underground coalmine WMSNs based on Multi-Band Orthogonal Frequency-Division Multiplexing Ultra-wide Band (MB-OFDM-UWB) is presented. The selection of MB-OFDM-UWB wireless transmission solution is based on the characteristics of underground coalmines. Network structure and design challenges are analyzed first, which is the foundation for further discussion. Then, key supporting technologies and open research areas in different layers are surveyed, and we provide a detailed literature review of the state of the art strategies, algorithms and general solutions in these issues. Finally, other research issues like localization, information processing, and network management are discussed.

  14. MB-OFDM-UWB Based Wireless Multimedia Sensor Networks for Underground Coalmine: A Survey

    Science.gov (United States)

    Han, Ruisong; Yang, Wei; You, Kaiming

    2016-01-01

    Safety production of coalmines is a task of top priority which plays an important role in guaranteeing, supporting and promoting the continuous development of the coal industry. Since traditional wireless sensor networks (WSNs) cannot fully meet the requirements of comprehensive environment monitoring of underground coalmines, wireless multimedia sensor networks (WMSNs), enabling the retrieval of multimedia information, are introduced to realize fine-grained and precise environment surveillance. In this paper, a framework for designing underground coalmine WMSNs based on Multi-Band Orthogonal Frequency-Division Multiplexing Ultra-wide Band (MB-OFDM-UWB) is presented. The selection of MB-OFDM-UWB wireless transmission solution is based on the characteristics of underground coalmines. Network structure and design challenges are analyzed first, which is the foundation for further discussion. Then, key supporting technologies and open research areas in different layers are surveyed, and we provide a detailed literature review of the state of the art strategies, algorithms and general solutions in these issues. Finally, other research issues like localization, information processing, and network management are discussed. PMID:27999258

  15. Influence of body position on muscle deoxy[Hb+Mb] during ramp cycle exercise.

    Science.gov (United States)

    DiMenna, Fred J; Bailey, Stephen J; Jones, Andrew M

    2010-09-30

    We used near-infrared spectroscopy (NIRS) to test the hypothesis that body position alters the sigmoidal response profile of muscle fractional O(2) extraction (estimated using deoxy[Hb+Mb]) during incremental cycle exercise. Seven male subjects (mean±SD age 32±13 years) completed a ramp incremental cycling test to exhaustion (30W/min) in both the supine and upright body positions. The sigmoidal (as opposed to hyperbolic) model that provided the better fit to deoxy[Hb+Mb] data during upright cycling was also present for the supine response; however, the slope of the sigmoid was increased (upright: 0.052±0.012 vs. supine: 0.090±0.036%⋅%P(peak)(-1); Prate (upright: 83±8 vs. supine: 68±19%P(peak)(-1); Pchanges occurred in the absence of a leftward shift of the sigmoid. We also found a significantly greater deltaV(O)₂/deltaW slope above compared to below gas exchange threshold (GET) for both conditions (upright: 9.8±0.5 vs. 8.2±0.9; supine: 10.7±0.9 vs. 8.0±0.8) and for supine compared to upright cycling above GET. These findings suggest that the supine posture affects O₂ extraction and V(O)₂ kinetics to a greater extent as work rate progresses during ramp incremental exercise. Copyright 2010 Elsevier B.V. All rights reserved.

  16. PERFORMANCE ANALYSIS OF PILOT BASED CHANNEL ESTIMATION TECHNIQUES IN MB OFDM SYSTEMS

    Directory of Open Access Journals (Sweden)

    M. Madheswaran

    2011-12-01

    Full Text Available Ultra wideband (UWB communication is mainly used for short range of communication in wireless personal area networks. Orthogonal Frequency Division Multiplexing (OFDM is being used as a key physical layer technology for Fourth Generation (4G wireless communication. OFDM based communication gives high spectral efficiency and mitigates Inter-symbol Interference (ISI in a wireless medium. In this paper the IEEE 802.15.3a based Multiband OFDM (MB OFDM system is considered. The pilot based channel estimation techniques are considered to analyze the performance of MB OFDM systems over Liner Time Invariant (LTI Channel models. In this paper, pilot based Least Square (LS and Least Minimum Mean Square Error (LMMSE channel estimation technique has been considered for UWB OFDM system. In the proposed method, the estimated Channel Impulse Responses (CIRs are filtered in the time domain for the consideration of the channel delay spread. Also the performance of proposed system has been analyzed for different modulation techniques for various pilot density patterns.

  17. Canada-U.S. Relations

    Science.gov (United States)

    2010-09-03

    reaffirmed this timetable and added goat meat, chicken, ginseng, pecans , and macadamia nuts as covered commodities. A final rule was issued on...major countries gather to discuss and coordinate international policies. The G-8 is a group of advanced countries (Canada, France, Germany, Italy ...Financial Crisis Since the mid-1970s, leaders from the G-7 (Canada, France, Germany, Italy , Japan, the United Kingdom, and the United States), a small group

  18. A staff shortage in Canada?

    International Nuclear Information System (INIS)

    Stoll, P.

    1995-01-01

    Attrition of experienced staff, falling student enrolments and closure of university courses are symptoms of the contraction of the Canadian nuclear industry over the last two decades. It is not alone. A study carried out by Human Resources Development Canada, a government department, to forecast the demand for qualified nuclear staff in Canada over the next 15 years has reached similar conclusions to an OECD/NEA study of its members' future personnel requirements. (author)

  19. Fusion Canada issue 29

    International Nuclear Information System (INIS)

    1995-10-01

    A short bulletin from the National Fusion Program highlighting in this issue Canada-Europe Accords: 5 year R and D collaboration for the International Thermonuclear Experimental Reactor (ITER) AECL is designated to arrange and implement the Memorandum of Understanding (MOU) and the ITER Engineering Design Activities (EDA) while EUROTAM is responsible for operating Europe's Fusion R and D programs plus MOU and EDA. The MOU includes tokamaks, plasma physics, fusion technology, fusion fuels and other approaches to fusion energy (as alternatives to tokamaks). STOR-M Tokamak was restarted at the University of Saskatchewan following upgrades to the plasma chamber to accommodate the Compact Toroid (CT) injector. The CT injector has a flexible attachment thus allowing for injection angle adjustments. Real-time video images of a single plasma discharge on TdeV showing that as the plasma density increases, in a linear ramp divertor, the plasma contact with the horizontal plate decreases while contact increases with the oblique plate. Damage-resistant diffractive optical elements (DOE) have been developed for Inertial Confinement Fusion (ICF) research by Gentac Inc. and the National Optics Institute, laser beam homogeniser and laser harmonic separator DOE can also be made using the same technology. Studies using TdeV indicate that a divertor will be able to pump helium from the tokamak with a detached-plasma divertor but helium extraction performance must first be improved, presently the deuterium:helium retention radio-indicates that in order to pump enough helium through a fusion reactor, too much deuterium-tritium fuel would be pumped out. 2 fig

  20. SCWR Concept in Canada

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-08-15

    AECL is designing the Canadian SCWR concept, which has evolved from the well-established pressuretube type CANDU® reactor. The Canadian SCWR is designed to produce electrical energy as the main product, plus process heat, hydrogen, industrial isotopes, and drinking water (through the desalination process) as supplementary products, all within a more compact reactor building. Another potential application of the available co-generated process heat is the extraction and refining of oil sands, which is presently achieved using co-generation with natural gas turbines and process heat. The extraction and upgrading process requires: thermal power to lower the viscosity and extract the oil; electric power for separation and refining equipment; and hydrogen gas for upgrading the oil product prior to transport. A National Program has been established in Canada to support R&D studies for the Canadian SCWR design. It covers key areas of interest (such as thermal hydraulics, safety, materials, and chemistry) to participants in the Generation-IV International Forum (GIF) SCWR designs. Results generated from the program are contributed to the GIF SCWR project management boards (PMBs). For example, heat transfer correlations have been derived using experimental data primarily obtained from fossil-plant related studies (which were started as early as 1930s. Materials and chemistry studies have evolved from operating experience of fossil-fired power plants to a) develop, and perform targeted testing of, materials for key components, in particular in-core reactor components that will be exposed to conditions not encountered in a fossil-fired boiler (such as irradiation and water radiolysis), and b) develop a suitable water chemistry to minimize corrosion and corrosion product transport.

  1. Troponin T or troponin I or CK-MB (or none?).

    Science.gov (United States)

    Collinson, P O

    1998-11-01

    Differential diagnosis of patients who present with chest pain remains problematical. It has been shown that 11.8-7% of patients with acute myocardial infarction (AMI) are sent home from the emergency department (ED). Audit of our own ED has shown the incidence of missed prognostically significant myocardial damage to be 6.7%. Diagnostic criteria for AMI have classically been based on the triad of history, ECG and measurement of cardiac enzymes. The choice of 'cardiac enzymes' has been dictated by the evolution of laboratory techniques, commencing with measurement of aspartate transaminase and progressing to measurement of creatine kinase (CK) and its MB isoenzyme (CK-MB). Measurement of CK-MB has been shown by both clinical studies and rigorous statistical analysis to represent the best test for the diagnosis of AMI. The advent of real time immunoassay together with advances in therapeutic options for management of acute coronary syndromes (ACS) has resulted in a paradigm shift in the approach to laboratory testing. Immunoassay for CK-MB (CK-MB mass measurement) is diagnostically superior to CK-MB activity measurement and is the test of choice for 'classical' AMI. Development of immunoassays for the cardiac troponins, i.e. cardiac troponin T (cTnT) and cardiac troponin I (cTnI), has enhanced diagnostic specificity. These measurements are completely specific for cardiac damage, allow quantitation of the extent of infarction and are diagnostically superior to CK-MB measurement. Applications of this specificity have included the differential diagnosis of CK elevation in arduous physical training, detection of myocardial damage after DC cardioversion and prediction of ejection fraction. Of more interest is the utility of these markers in management of patients presenting without clear electrocardiographic changes. Diagnosis and management of patients presenting with ST segment elevation has been clarified by large clinical trials of thrombolytic agents. In such

  2. Protein synthesis rate measured with l-[1-{sup 11}C]tyrosine positron emission tomography correlates with mitotic activity and MIB-1 antibody-detected proliferation in human soft tissue sarcomas

    Energy Technology Data Exchange (ETDEWEB)

    Plaat, B.; Mastik, M.; Molenaar, W. [Department of Pathology, University Hospital Groningen (Netherlands); Kole, A.; Vaalburg, W. [PET Centre, University Hospital Groningen (Netherlands); Hoekstra, H. [Department of Surgical Oncology, University Hospital Groningen (Netherlands)

    1999-04-29

    Protein synthesis rate (PSR) can be assessed in vivo using positron emission tomography with l-[1-{sup 11}C]tyrosine (TYR-PET). Biological activity of soft tissue sarcomas (STS) can be measured in vitro by the mitotic rate and number of proliferating cells. In STS the grade of malignancy, in which the mitotic index plays a major role, is considered to be the major standard in predicting biological tumour behaviour. This study was designed to test the validity of TYR-PET in relation to different histopathological features. In 21 patients with untreated STS, the PSR was measured using TYR-PET. The number of mitoses was counted and tumours were graded according to the grading system of Coindre et al. (Cancer 1986; 58:306-309). Proliferative activity was assessed by immunohistological detection of the Ki-67 nuclear antigen using MIB-1 monoclonal antibody. To test the association between the PSR and these tumour parameters, a correlation analysis was performed. A significant (P<0.05) correlation was found between PSR and the Ki-67 proliferation index (R = 0.54), and between PSR and mitotic rate (R = 0.64). There was no correlation between PSR and tumour grade. The present study in malignant soft tissue tumours relates in vivo tumour metabolism as established with TYR-PET to tumour activity measured in vitro and indicates that the non-invasive method of TYR-PET can estimate the mitotic and proliferative activity in STS. (orig.) With 2 figs., 2 tabs., 30 refs.

  3. The reflector effect on the neutron lifetimes in the IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Gonnelli, Eduardo

    2013-01-01

    The aim of this study is to present the reflector effect on the neutron lifetimes in the IPEN/MB-01 reactor. The proposed method requires an approach which takes into account both the reflector and the core, so that the point kinetics equations, which constitute the theoretical basis of all mathematical development, contemplate both regions of the reactor. From these equations, as known as two regions kinetics point equations, theoretical expressions are obtained for the Auto Power Spectral Densities (APSD), which are used for least squares fit of the experimental data of APSD obtained in several subcritical states. The prompt neutron generation time, the neutron lifetimes in the reflector and the neutron return fraction from the reflector to the core are derived from the fitting. (author)

  4. Toward Joint Hypothesis-Tests Seismic Event Screening Analysis: Ms|mb and Event Depth

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Dale [Los Alamos National Laboratory; Selby, Neil [AWE Blacknest

    2012-08-14

    Well established theory can be used to combine single-phenomenology hypothesis tests into a multi-phenomenology event screening hypothesis test (Fisher's and Tippett's tests). Commonly used standard error in Ms:mb event screening hypothesis test is not fully consistent with physical basis. Improved standard error - Better agreement with physical basis, and correctly partitions error to include Model Error as a component of variance, correctly reduces station noise variance through network averaging. For 2009 DPRK test - Commonly used standard error 'rejects' H0 even with better scaling slope ({beta} = 1, Selby et al.), improved standard error 'fails to rejects' H0.

  5. Apoptotic potential of two Caryophyllaceae species in MCF-7 and MDA-MB-468 cell lines

    Directory of Open Access Journals (Sweden)

    M. Mosaddegh

    2018-01-01

    Full Text Available Background and objectives: Plants have been used to treat diseases like cancer for many years and today the trend towards their use is increasing. One of the most effective mechanisms of plants against cancer is inducing apoptosis. Apoptosis is a programmed cell death which acts opposite to cell division. It starts in response to some stimuli. Despite the effectiveness of apoptosis inducing agents, their use has been limited due to side effects and resistance to these treatments; so, applying medicinal herbs due to their lower cost and toxicity has drawn attentions. Recent research at the Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences on two medicinal plants Acanthophyllum bracteatum and A. microcephalum has shown cytotoxic effects of these two species, but the mechanism of their toxicity has remained unknown; thus, the present study was designed to evaluate the apoptotic potential of Acanthophyllum bracteatum and A. microcephalum. Methods: In the present study, the cytotoxic effects of the methanol extract of Acanthophyllum bracteatum and A. microcephalum was evaluated against MCF-7 and MDA-MB-468 cells by MTT assay; furthermore, their apoptosis potential has been evaluated by annexin-V/propidium iodide assay and Hoechst 33258 staining in the same cell lines. Results: The methanol extract of A. microcephalum and A. bracteatum showed cytotoxic effects against MCF-7 and MDA-MB-468 cell lines with IC50 values of 64, 159 and 102, 250 μg/mL, respectively. The results of the apoptosis assays confirmed the potential of the two plants extracts to induce apoptosis in both cell lines while A. microcephalum demonstrated more considerable results. Conclusion: A. microcephalum could be a suitable choice for further breast cancer studies.

  6. Canada's isotope crisis : what next?

    International Nuclear Information System (INIS)

    Nathwani, J.; Wallace, D.

    2010-01-01

    Canada urgently requires a rigorous debate on the strategic options for ensuring a robust, reliable, and affordable supply of radioactive isotopes. Should the debate be confined to how Canada can best develop the necessary technologies solely for our own use or should Canada abandon the idea of producing its own isotope supply and any future aspirations to serve the global market? Canada's Isotope Crisis focuses on the central policy question: do we dare to try to shape the future or do we retreat into silence because we are not prepared to make the necessary investments for the future well-being of Canadians? This volume showcases pointed essays and analysis from members of the academy and individuals who have made contributions to the development of medical isotopes and pioneered their use in medical practice. It also includes commentary from those involved in the production, manufacturing, processing, and distribution of isotopes. Canada's Isotope Crisis is a multi-disciplinary effort that addresses the global dimension of isotope supply and combines expert opinions on the present and past with knowledge of the relevant government agencies and the basis for their decisions at critical junctures.

  7. Electric power in Canada 1993

    International Nuclear Information System (INIS)

    1994-01-01

    The electric power industry in Canada in 1993 is reviewed. Items discussed include: the international context of Canadian electricity; regulatory structures; electricity and the environment; electricity consumption; electricity generation; generating capacity and reserve; electricity trade; transmission; electric utility investment and financing; costing and pricing; electricity outlook; demand-side management; and non-utility generation. Appended information is presented on installed capacity and electrical energy consumption in Canada, installed generating capacity, conventional thermal capacity by principal fuel type, provincial electricity imports and exports, Canadian electricity exports by exporter and importer, generation capacity by type, installed generating capacity expansion in Canada by station, federal environmental standards and guidelines, and prices paid by major electric utilities for non-utility generation. 23 figs., 95 tabs

  8. Electric power in Canada 1992

    International Nuclear Information System (INIS)

    1993-01-01

    The electric power industry in Canada in 1991 is reviewed. Items discussed include: the international context of Canadian electricity; regulatory structures; electricity and the environment; electricity consumption; electricity generation; generating capacity and reserve; electricity trade; transmission; electric utility investment and financing; costing and pricing; electricity outlook; demand-side management; and non-utility generation. Appended information is presented on installed capacity and electrical energy consumption in Canada, installed generating capacity, conventional thermal capacity by principal fuel type, provincial electricity imports and exports, Canadian electricity exports by exporter and importer, generation capacity by type, installed generating capacity expansion in Canada by station, federal environmental standards and guidelines, and prices paid by major electric utilities for non-utility generation. 26 figs., 90 tabs

  9. Electric power in Canada 1993

    International Nuclear Information System (INIS)

    1994-01-01

    The electric power industry in Canada in 1993 is reviewed. Items discussed include: the international context of Canadian electricity; regulatory structures; electricity and the environment; electricity consumption; electricity generation; generating capacity and reserve; electricity trade; transmission; electric utility investment and financing; costing and pricing; electricity outlook; demand-side management; and non-utility generation. Information is appended on installed capacity and electrical energy consumption in Canada, installed generating capacity, conventional thermal capacity by principal fuel type, provincial electricity imports and exports, Canadian electricity exports by exporter and importer, generation capacity by type, installed generating capacity expansion in Canada by station, federal environmental standards and guidelines, and prices paid by major electric utilities for non-utility generation. 26 figs., 90 tabs

  10. Canada report on bioenergy 2009

    International Nuclear Information System (INIS)

    2009-01-01

    Canada possesses significant forest resources. This paper reviewed Canada's bioenergy potential and market. Biomass in Canada is used to produce heat and power, as well as to produce ethanol and biodiesel. Biomass is also used to produce pyrolysis oil and wood pellets. Biomass resources included woody biomass; annual residue production; hog fuel piles; forest harvest waste and urban wood residues; agricultural residues; and municipal solid wastes. Trends in biomass production and consumption were discussed, and current biomass users were identified. A review of biomass prices was presented, and imports and exports for ethanol, biodiesel, pyrolysis oil, and wood pellets were discussed. Barriers and opportunities for trade were also outlined. 6 tabs., 6 figs. 1 appendix.

  11. Western Canada Sedimentary Basin competitiveness

    International Nuclear Information System (INIS)

    Millar, R.H.G.

    1996-01-01

    Recent dramatic expansion of the natural gas industry in the Western Canada Sedimentary Basin provided ample proof of the potential of this area for further development of natural gas supply. However, the inherent competitive advantages provided by the Western Canada Sedimentary Basin were said to have been offset by low netback prices resulting in poor producer economics when competitiveness is measured by availability of opportunities to find and develop gas supply at costs low enough to ensure attractive returns. Technology was identified as one of the key elements in improving basin competitiveness, but the greatest potential lies in reduced transportation costs and increased access to North American market centres. 8 figs

  12. The effects of prior calcium channel blocker therapy on creatine kinase-MB levels after percutaneous coronary interventions

    Directory of Open Access Journals (Sweden)

    Oyku Gulmez

    2008-12-01

    Full Text Available Oyku Gulmez, Ilyas Atar, Bülent Ozin, Mehmet Emin Korkmaz, Aslı Atar, Alp Aydinalp, Aylin Yildirir, Haldun MuderrisogluBaskent University Faculty of Medicine, Department of Cardiology, Ankara, TurkeyBackground: Use of intracoronary calcium channel blockers (CCBs during percutaneous coronary intervention (PCI has been shown to have favorable effects on coronary blood flow. We aimed to investigate the effects of CCBs administrated perorally on creatine kinase-MB (CK-MB levels in patients undergoing elective PCI.Methods: A total of 570 patients who underwent PCI were evaluated for CK-MB elevation. Patients who were on CCB therapy when admitted to the hospital constituted the CCB group. No CCBs were given to the rest of the patients during the periprocedural period and these patients served as the control group. Blood samples for CK-MB were obtained before and at 6 h, 24 h, and 36 h after the procedure.Results: 217 patients were in the CCB group (mean age 60.2 ± 9.3 years, 162 males, and 353 were in the control group (mean age 60.0 ± 10.1 years, 262 males. CK-MB levels increased above the normal values in 41 patients (18.9% of the CCBs group and in 97 patients (27.5% of the control group (p = 0.02. Median CK-MB levels were significantly higher in the control group for all studied hours (for all p < 0.05.Conclusions: Prior oral CCB therapy may have favorable effects in preventing myocyte necrosis after elective PCI.Keywords: calcium channel blockers, myonecrosis, percutaneous coronary interventions

  13. Linear Analysis of Autonomic Activity and Its Correlation with Creatine Kinase-MB in Overt Thyroid Dysfunctions.

    Science.gov (United States)

    Mavai, Manisha; Singh, Yogendra Raj; Gupta, R C; Mathur, Sandeep K; Bhandari, Bharti

    2018-04-01

    Autonomic activity may be deranged in thyroid dysfunctions and may lead to cardiovascular morbidity and mortality. Myopathy is a common manifestation in thyroid disorders and may be associated with raised serum creatine kinase (CK). We hypothesized that cardiovascular abnormality in thyroid dysfunction may manifest as raised CK-MB. This study was designed to investigate the correlation of CK and its isoform CK-MB with thyroid profile and linear parameters of heart rate variability (HRV). The study was conducted on 35 hypothyroid and hyperthyroid patients each, and 25 age-matched healthy controls. Autonomic activity was assessed by simple short term 5-min HRV. Biochemical evaluation of serum thyroid profile, CK-NAC and CK-MB were estimated in all the subjects. Our results demonstrated low HRV in hypo- as well as hyperthyroid patients. We observed significantly higher serum CK levels in hypothyroid patients when compared to hyperthyroids and controls. However, no significant differences were observed in CK-MB levels in the three groups. Significant positive correlation of CK with TSH and negative correlation with some HRV parameters (LF power, HF power, total power, SDNN, RMSSD) was observed in hypothyroid patients. Whereas correlation of CK-MB with thyroid profile as well as HRV parameters was non-significant in all the groups. Based on the CK and CK-MB findings and their correlation, we conclude that the cardiovascular changes seen in thyroid dysfunctions may primarily be due to autonomic imbalance without apparent cardiac muscle involvement. Whereas, raised CK levels indicate predominantly skeletal muscle involvement in hypothyroid patients.

  14. Canada-U.S. Relations

    Science.gov (United States)

    2009-05-12

    56 RBC Financial Group, Daily Forex Fundamentals, February 27, 2009. [ http...www.actionforex.com/fundamental- analysis/daily- forex -fundamentals/canada%27s-fourth%11quarter-current-account-moves-into-deficit-after-nine-years- of-surpluses...sharing, infrastructure improvements, improvement of compatible immigration databases , visa policy coordination, common biometric identifiers in

  15. Food irradiation: progress in Canada

    International Nuclear Information System (INIS)

    Wilson, B.K.

    1985-01-01

    The subject is discussed under the headings: food irradiation regulatory situation in Canada; non-regulatory developments (poultry irradiation; fish irradiation; Government willingness to fund industry initiated projects; Government willingness to establish food irradiation research and pilot plant facilities; food industry interest is increasing significantly; Canadian Consumers Association positive response; the emergence of new consulting and entrepreneurial firms). (U.K.)

  16. Comparing pyloromyotomy outcomes across Canada.

    Science.gov (United States)

    Ednie, Alexander C; Amram, Ofer; Schuurman, Nadine; Yanchar, Natalie L

    2017-05-01

    Changing patterns of referral and management of hypertrophic pyloric stenosis (HPS) in North America have recently been described. Comfort with perioperative management, anesthesia, and corrective surgery have been cited as reasons for these changes. Our primary objective was to assess pyloromyotomy outcomes between different hospital types across Canada. The secondary objective was to geospatially map all pyloromyotomies to identify regions of higher HPS incidence across Canada. Data of all pyloromyotomies done between 2011 and 2013 were acquired from Canadian Institute for Health Information (CIHI). Complication rates and length of hospital stay (LOS) were analyzed. Postal codes for each patient were used to geospatially map regions of higher HPS incidence. A total of 1261 pyloromyotomies were assessed. There was no difference in LOS or complication rates between different hospital types or surgeon group. Open pyloromyotomies were done in 75% of the cases. Several regions of higher HPS incidence were identified across Canada. This study found no difference in complication rate or LOS stay between hospital type and surgeon type across Canada. This may reflect a previously identified referral trend in the United States towards pediatric centers. Several regions of higher HPS incidence were identified, and may aid in identifying genetic elements causing HPS. 2c. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

  17. Canada report on bioenergy 2008

    International Nuclear Information System (INIS)

    Bradley, D.

    2008-06-01

    Canada is a nation rich in fossil fuel resources. Canada has a large, well-developed forest sector and is one of the world's largest exporters of wood products. Although national bioenergy policies exist, provincial policies regarding forest resources are necessary because 77 per cent of Canada's forests are under provincial jurisdiction. This report presented an update on Canada's bioenergy policy and resources. The report discussed biomass resources such as woody biomass; agricultural residues; and municipal waste. The use of biomass was presented with particular reference to heat and power; biofuels production; pyrolysis oil; wood pellets; and trends in biomass production and consumption. Current biomass users and biomass prices were also examined. Last, the report addressed imports and exports of ethanol, biodiesel, pyrolysis oil, and wood pellets as well as barriers and opportunities to trade. A list of Canadian bioenergy initiatives and programs was also provided. It was concluded that the greatest opportunities for trade are to succeed in research on super-densified pellets; raise ocean shipping capacity to bring down rates; and to establish and entire biomass industry in Newfoundland Labrador. 20 tabs., 8 figs., 1 appendix

  18. Canada and Missions for Peace

    International Development Research Centre (IDRC) Digital Library (Canada)

    The study focuses primarily on Canada's role in these missions in light of ..... simply because peacekeeping has been the chief form of UN intervention and one in which ... Other factors, such as financial constraints and increasing social problems ..... Luck, superior armaments, the shortage of professional officers among the ...

  19. Canada puts emphasis on SMR

    International Nuclear Information System (INIS)

    Anon.

    2017-01-01

    Thanks to hydroelectricity and 16% share of nuclear power, Canada is among the few countries to respect GIEC's 2050 climate objectives: producing 80% of electricity without emitting CO 2 . In the context of a growing power demand, Canada has integrated nuclear energy in its energy scenarios. Small Modular Reactors (SMR) are considered as an efficient means to replace diesel generators used in small isolated communities. Several North America start-ups such as Terrestrial Energy that develops molten salt reactors, have moved to Canada. The British firm Moltex has chosen Canadian Nuclear Safety Authority (CCSN for the certification of its 4. generation reactor. In Ontario, Canada's most populated province, nuclear energy produces 60% of its electricity consumption and has allowed the progressive shutdown of all coal-fed power plants of the province. Between 2000 and 2013 nuclear power increased by 20% whereas the coal share in power production dropped by 27%. The 2014 Toronto Public Health report highlights that since 2004 premature mortality has dropped by 23% and the hospitalization due to air pollution by 41%. (A.C.)

  20. Uranium: the nuclear fuel. [Canada

    Energy Technology Data Exchange (ETDEWEB)

    Smith, E E.N. [Eldorado Nuclear Ltd., Ottawa, Ontario (Canada)

    1976-05-01

    A brief history is presented of Canadian uranium exploration, production, and sales. Statistics show that Canada is a good customer for its own uranium due to a rapidly expanding nuclear power program. Due to an average 10 year lag between commencement of exploration and production, and with current producers sold out through 1985, it is imperative that exploration efforts be increased.

  1. Nuclear fuel activities in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Cox, D S [Fuel Development Branch, Chalk River Labs., AECL (Canada)

    1997-12-01

    Nuclear fuel activities in Canada are considered in the presentation on the following directions: Canadian utility fuel performance; CANDU owner`s group fuel programs; AECL advanced fuel program (high burnup fuel behaviour and development); Pu dispositioning (MOX) activities. 1 tab.

  2. Canada-India Reactor (CIR)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1960-12-15

    Design information on the Canada-India Reactor is presented. Data are given on reactor physics, the core, fuel elements, core heat transfer, control, reactor vessel, fluid flow, reflector and shielding, containment, cost estimates, and research facilities. Drawings of vertical and horizontal sections of the reactor and fluid flow are included. (M.C.G.)

  3. Canada's commitment to nuclear technology

    International Nuclear Information System (INIS)

    Stewart, Murray J.

    1998-01-01

    This paper gives a broad update on all facets of the Canadian nuclear industry and demonstrates Canada's continuing commitment to nuclear technology. Canada has developed a global leadership position in nuclear technology for power generation, uranium production and isotope supply. This commitment is being further enhanced by successes in international markets with Candu technology, new uranium mine developments in our province of Saskatchewan, and expanding isotope capabilities including the construction of two new production reactors. Korea's economy is benefiting through collaboration with Canada's leading nuclear companies, both in Korea and Canada. These collaborations have the potential to expand considerably with the implementation of the Kyoto Framework Convention on Climate Change and the anticipated increased demand for new nuclear power generation installations in all major global markets. Much has been publicized about the situation surrounding Ontario Hydro Nuclear and its nuclear recovery program. This paper gives the background and highlights the actions within Ontario and Ontario Hydro designed to ensure the long term recovery of all twenty nuclear units in Ontario. The presentation at the conference will bring the audience completely up-to-date on recent events. (author)

  4. Canada-China power experience

    International Nuclear Information System (INIS)

    Taylor, A.

    1995-01-01

    International energy opportunities were reviewed, with emphasis on China, and on Canada-China Power Inc., alternatively known as 'Team Canada'. Canada-Chine Power Inc., is a company founded by three of Canada's leading engineering consulting firms, i.e., Monenco AGRA Inc., SNC Lavalin Inc., and Acres International Limited. An office was established in Beijing in January 1994. Other Canadian manufacturers and engineering companies also have been actively pursuing hydro power opportunities in China for several years in view of China's enormous demand for power. It was estimated that by the year 2000, China will install 137 GW of new capacity, and foreign investment will account for approximately a third of the growth. AGRA is working on a 5400 MW thermal plant on Hainan Island, and is in final negotiations with the Yangtze Three Gorges Development Corporation for a management information system for their 18200 MW multi-purpose project. Criteria used by AGRA to identify international opportunities include: (1) a large capital spending program in fields with capabilities, expertise and past experience, (2) access to international funding, (3) competitive Canadian technology, and (4) an acceptable business and cultural climate. In assessing the opportunities, AGRA decided to concentrate on providing technologies in greatest need, such as project management systems, computer engineering and CAD systems, and clean coal technology

  5. Unique Measles Virus in Canada

    Centers for Disease Control (CDC) Podcasts

    2017-08-24

    Dr. Shelley Deeks, chief of communicable diseases at Public Health Ontario, discusses a measles outbreak in Canada.  Created: 8/24/2017 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 8/24/2017.

  6. Heavy reflector experiments composed of carbon steel and nickel in the IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Santos, Adimir dos; Silva, Graciete Simoes de Andrade e; Mura, Luis Felipe; Jerez, Rogerio; Mendonca, Arlindo Gilson; Fuga, Rinaldo

    2013-01-01

    The heavy reflector experiments performed in the IPEN/Mb-01 research reactor facility comprise a set of critical configurations employing the standard 28x26-fuel-rod configuration. The heavy reflector either, carbon steel or nickel plates was placed at one of the faces of the IPEN/MB-01 reactor. Criticality is achieved by inserting the control banks BC1 and BC2 to the critical position. 32 plates around 0.3 mm thick were used in all the experiment. The chosen distance between last fuel rod row and the first laminate for all types of laminates was 5.5 mm. Considering initially the carbon steel case, the experimental data reveal that the reactivity decreases up to the fifth plate and after that it increases, becomes nearly zero (which was equivalent to initial zero excess reactivity with zero plates) for the 28 plates case and reaches a value of 42.73 pcm when the whole set of 32 plates are inserted in the reflector. This is a very striking result because it demonstrates that when all 32 plates are inserted in the reflector there is a net gain of reactivity. The reactivity behavior demonstrates all the physics events already mentioned in this work. When the number of plates are small (around 5), the neutron absorption in the plates is more important than the neutron reflection and the reactivity decreases. This condition holds up to a point where the neutron reflection becomes more important than the neutron absorption in the plates and the reactivity increases. The experimental data for the nickel case shows the main features of the carbon steel case, but for the carbon steel case the reactivity gain is small, thus demonstrating that carbon steel or essentially iron has not the reflector capability as the nickel laminates do. The measured data of nickel plates show a higher reactivity gain, thus demonstrating that nickel is a better reflector than iron. The theoretical analysis employing MCNP5 and ENDF/B-VII.0 show that the calculated results have good results up to

  7. Building better health care leadership for Canada: implementing evidence

    National Research Council Canada - National Science Library

    Denis, Jean-Louis; Sullivan, Terrence James

    2011-01-01

    ... of the Government of Canada through the Canada Book Fund for our publishing activities. Library and Archives Canada Cataloguing in Publication Building better health care leadership for Canada: imple...

  8. Fusion Canada issue 32. Final edition

    International Nuclear Information System (INIS)

    1997-07-01

    Fusion Canada is a bulletin of the National Fusion Program, this is the last edition. Included in this July edition are articles on Funding for Canada's fusion program, Research and Development on TdeV-96 , Divertor Maintenance Robotics and reference listing for Canada's Fusion research and development sites

  9. Advancing clean energy technology in Canada

    International Nuclear Information System (INIS)

    Munro, G.

    2011-01-01

    This paper discusses the development of clean energy technology in Canada. Energy is a major source of Canadian prosperity. Energy means more to Canada than any other industrialized country. It is the only OECD country with growing oil production. Canada is a stable and secure energy supplier and a major consumer. Promoting clean energy is a priority to make progress in multiple areas.

  10. Influence of iron and beryllium additions on heat resistance of silicide coatings on TsMB-30 molybdenum alloy

    International Nuclear Information System (INIS)

    Zajtseva, A.L.; Fedorchuk, N.M.; Lazarev, Eh.M.; Korotkov, N.A.

    1985-01-01

    Alloying of titanium modified silicide coatings on TsMB-30 molybdenum alloy with iron or beryllium is stated to improve their protective properties. Coatings with low content of alloying elements have the best protective properties. Service life of coatings is determined by the formed oxide film and phase transformations taking place in the coating

  11. Monitoring of tumor growth and metastasis potential in MDA-MB-435s/tk-luc human breast cancer xenografts

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Y.-F. [Department of Radiological Sciences, National Yang-Ming University, 155, Sec. 2, Li-Nong Street, Pei-tou 112, Taipei, Taiwan (China); Lin, Y.-Y. [Department of Radiological Sciences, National Yang-Ming University, 155, Sec. 2, Li-Nong Street, Pei-tou 112, Taipei, Taiwan (China); Wang, H.-E. [Department of Radiological Sciences, National Yang-Ming University, 155, Sec. 2, Li-Nong Street, Pei-tou 112, Taipei, Taiwan (China); Liu, R.-S. [Department of Nuclear Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan (China); Nuclear Medicine Department, Veterans General Hospital, Taipei, Taiwan (China); Pang Fei [Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan (China); Hwang, J.-J. [Department of Radiological Sciences, National Yang-Ming University, 155, Sec. 2, Li-Nong Street, Pei-tou 112, Taipei, Taiwan (China)]. E-mail: jjhwang@ym.edu.tw

    2007-02-01

    Molecular imaging of reporter gene expression provides a rapid, sensitive and non-invasive monitoring of tumor behaviors. In this study, we reported the establishment of a novel animal model for longitudinal examination of tumor growth kinetics and metastatic spreading in vivo. The highly metastatic human breast carcinoma MDA-MB-435s cell line was engineered to stably express herpes simplex virus type 1 thymidine kinase (HSV-1-tk) and luciferase (luc). Both {sup 131}I-FIAU and D-luciferin were used as reporter probes. For orthotopic tumor formation, MDA-MB-435s/tk-luc cells were implanted into the first nipple of 6-week-old female NOD/SCID mice. For metastatic study, cells were injected via the lateral tail vein. Mice-bearing MDA-MB-435s/tk-luc tumors were scanned for tumor growth and metastatsis using Xenogen IVIS50 system. Gamma scintigraphy and whole-body autoradiography were also applied to confirm the tumor localization. The results of bioluminescence imaging as well as histopathological finding showed that tumors could be detected in femur, spine, ovary, lungs, kidney, adrenal gland, lymph nodes and muscle at 16 weeks post i.v. injection, and correlated photons could be quantified. This MDA-MB-435s/tk-luc human breast carcinoma-bearing mouse model combined with multimodalities of molecular imaging may facilitate studies on the molecular mechanisms of cancer invasion and metastasis.

  12. Photonic Ultra-Wideband 781.25-Mb/s Signal Generation and Transmission Incorporating Digital Signal Processing Detection

    DEFF Research Database (Denmark)

    Gibbon, Timothy Braidwood; Yu, Xianbin; Tafur Monroy, Idelfonso

    2009-01-01

    The generation of photonic ultra-wideband (UWB) impulse signals using an uncooled distributed-feedback laser is proposed. For the first time, we experimentally demonstrate bit-for-bit digital signal processing (DSP) bit-error-rate measurements for transmission of a 781.25-Mb/s photonic UWB signal...

  13. Production and characterisation of glycolipid biosurfactant by Halomonas sp. MB-30 for potential application in enhanced oil recovery.

    Science.gov (United States)

    Dhasayan, Asha; Kiran, G Seghal; Selvin, Joseph

    2014-12-01

    Biosurfactant-producing Halomonas sp. MB-30 was isolated from a marine sponge Callyspongia diffusa, and its potency in crude oil recovery from sand pack column was investigated. The biosurfactant produced by the strain MB-30 reduced the surface tension to 30 mN m(-1) in both glucose and hydrocarbon-supplemented minimal media. The critical micelle concentration of biosurfactant obtained from glucose-based medium was at 0.25 mg ml(-1) at critical micelle dilution 1:10. The chemical structure of glycolipid biosurfactant was characterised by infrared spectroscopy and proton magnetic resonance spectroscopy. The emulsification activity of MB-30 biosurfactant was tested with different hydrocarbons, and 93.1 % emulsification activity was exhibited with crude oil followed by kerosene (86.6 %). The formed emulsion was stable for up to 1 month. To identify the effectiveness of biosurfactant for enhanced oil recovery in extreme environments, the interactive effect of pH, temperature and salinity on emulsion stability with crude oil and kerosene was evaluated. The stable emulsion was formed at and above pH 7, temperature >80 °C and NaCl concentration up to 10 % in response surface central composite orthogonal design model. The partially purified biosurfactant recovered 62 % of residual crude oil from sand pack column. Thus, the stable emulsifying biosurfactant produced by Halomonas sp. MB-30 could be used for in situ biosurfactant-mediated enhanced oil recovery process and hydrocarbon bioremediation in extreme environments.

  14. Elevated CK-MB isoenzyme after exercise stress test and atrial pacing in patients with ischemic heart disease

    International Nuclear Information System (INIS)

    Marmor, A.T.; Klein, R.; Plich, M.; Groshar, D.; Schneeweiss, A.

    1988-01-01

    Using a highly sensitive monoclonal antibody kit for CK-MB, significant release of small amounts of CK-MB isoenzyme after exercise stress test was detected 4 to 6 h after induction of ischemia. This occurred in ten out of 15 patients with ischemic heart disease (66 percent) and in only one of the 18 healthy subjects (5.6 percent) serving as a control group. In five patients with coronary artery disease in whom atrial pacing was performed with simultaneous blood sampling from coronary sinus, a drastic elevation in CK-MB isoenzyme (from 2.04 +/- 2.06 ng/L to 10.88 +/- 6.9 ng/L; p less than 0.001) was detected within 10 to 30 min after induction of acute ischemia. A small but significant increase in total CK also was detected (from 21 +/- 12 IU/L to 52 +/- 14IU/L; p less than 0.01). These preliminary observations have to be further investigated in a larger group of patients before a definitive conclusion can be reached about the clinical significance of CK-MB release during exercise

  15. Monitoring of tumor growth and metastasis potential in MDA-MB-435s/tk-luc human breast cancer xenografts

    International Nuclear Information System (INIS)

    Chang, Y.-F.; Lin, Y.-Y.; Wang, H.-E.; Liu, R.-S.; Pang Fei; Hwang, J.-J.

    2007-01-01

    Molecular imaging of reporter gene expression provides a rapid, sensitive and non-invasive monitoring of tumor behaviors. In this study, we reported the establishment of a novel animal model for longitudinal examination of tumor growth kinetics and metastatic spreading in vivo. The highly metastatic human breast carcinoma MDA-MB-435s cell line was engineered to stably express herpes simplex virus type 1 thymidine kinase (HSV-1-tk) and luciferase (luc). Both 131 I-FIAU and D-luciferin were used as reporter probes. For orthotopic tumor formation, MDA-MB-435s/tk-luc cells were implanted into the first nipple of 6-week-old female NOD/SCID mice. For metastatic study, cells were injected via the lateral tail vein. Mice-bearing MDA-MB-435s/tk-luc tumors were scanned for tumor growth and metastatsis using Xenogen IVIS50 system. Gamma scintigraphy and whole-body autoradiography were also applied to confirm the tumor localization. The results of bioluminescence imaging as well as histopathological finding showed that tumors could be detected in femur, spine, ovary, lungs, kidney, adrenal gland, lymph nodes and muscle at 16 weeks post i.v. injection, and correlated photons could be quantified. This MDA-MB-435s/tk-luc human breast carcinoma-bearing mouse model combined with multimodalities of molecular imaging may facilitate studies on the molecular mechanisms of cancer invasion and metastasis

  16. Cardiac troponin T and CK-MB mass release after visually successful percutaneous transluminal coronary angioplasty in stable angina pectoris

    DEFF Research Database (Denmark)

    Ravkilde, J; Nissen, H; Mickley, H

    1994-01-01

    The incidence of cardiac troponin T (Tn-T) and creatine kinase (CK) isoenzyme MB mass release was studied in 23 patients with stable angina pectoris undergoing visually successful percutaneous transluminal coronary angioplasty (PTCA). Serial blood samples were drawn for measurement of serum Tn...

  17. Engineering nutritious proteins: improvement of stability in the designer protein MB-1 via introduction of disulfide bridges.

    Science.gov (United States)

    Doucet, Alain; Williams, Martin; Gagnon, Mylene C; Sasseville, Maxime; Beauregard, Marc

    2002-01-02

    Protein design is currently used for the creation of new proteins with desirable traits. In this laboratory the focus has been on the synthesis of proteins with high essential amino acid content having potential applications in animal nutrition. One of the limitations faced in this endeavor is achieving stable proteins despite a highly biased amino acid content. Reported here are the synthesis and characterization of two disulfide-bridged mutants derived from the MB-1 designer protein. Both mutants outperformed their parent protein MB-1 with their bridge formed, as shown by circular dichroism, size exclusion chromatography, thermal denaturation, and proteolytic degradation experiments. When the disulfide bridges were cleaved, the mutants' behavior changed: the mutants significantly unfolded, suggesting that the introduction of Cys residues was deleterious to MB-1-folding. In an attempt to compensate for the mutations used, a Tyr62-Trp mutation was performed, leading to an increase in bulk and hydrophobicity in the core. The Trp-containing disulfide-bridged mutants did not behave as well as the original MB-1Trp, suggesting that position 62 might not be adequate for a compensatory mutation.

  18. Measurements of the neutron energy spectra in the core of IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Martins, Fernando Prat Goncalves

    2006-01-01

    This work presents the neutron spectrum measurements in the Reactor IPEN/MB-01 using very thin activation detectors in the metallic form, in reactor core, in moderator region. An articulated device allows that the foils are inserted in the central position of reactor core, ensuring that all the foils are irradiated in the same position. The activation detectors of different materials such Au 197 , Mg 24 , Ti 4 '8, In 115 , Sc 45 and others, were selected to cover a large range of neutron spectrum. After the irradiation, the activation detectors were submitted to a spectrometry gamma by using a system of counting with high purity Germanium, to obtain the saturation activity per target nuclide. The saturation activity is one of the main data of input of unfolding code SANDBP, that through an iterative adjustment, modify the spectrum that better agree with the dataset of code input, composition mainly for measure reaction rate per target nuclide and a initial input spectrum, calculated for Hammer-Technion code, supplying a solution spectrum. (author)

  19. Improved Laccase Production by Trametes pubescens MB89 in Distillery Wastewaters

    Directory of Open Access Journals (Sweden)

    P. J. Strong

    2011-01-01

    Full Text Available Various culture parameters were optimised for laccase synthesis by Trametes pubescens MB89, including pH, carbon source, nitrogen source, lignocellulosic supplements, and reported inducers. Glucose, in conjunction with a complex nitrogen source at pH 5.0, resulted in the highest laccase yield. Adding ethanol, copper, or 2,5-xylidine prior to inoculation further improved laccase concentrations. The addition of 2,5-xylidine was further investigated with multiple additions applied at varying times. This novel application substantially improved laccase production when applied regularly from inoculation and during the growth phase, and also countered glucose repression of laccase synthesis. Single and multiple factor changes were studied in three distillery wastewaters and a wine lees. A synergistic increase in laccase synthesis was observed with the addition of glucose, copper, and 2,5-xylidine. Single addition of 2,5-xylidine proved most beneficial with distillery wastewaters, while copper addition was most beneficial when using the wine lees as a culture medium.

  20. Development of a preliminary decommissioning plan of the reactor IPEN/MB-01

    International Nuclear Information System (INIS)

    Vivas, Ary de Souza; Carneiro, Alvaro Luiz Guimaraes

    2013-01-01

    Around the world, many nuclear plants were built and need to be turned off at a certain time because they are close to their recommended time of use is approximately 50 years. So the IAEA (International Atomic Energy Agency), seeks to guide and recommend, through publications, guidelines for the conduct of activities both for decommissioning nuclear power plants and for research reactors, with special attention to countries that do not have a framework regulatory Legal that sustain the activities of decommissioning. Brazil, so far, does not have a specific standard to guide the steps of the guidelines regarding decommissioning research reactors, having only a standard applied to decommissioning power plants which was published in November 2012. The Nuclear and Energy Research Institute (IPEN) has two research reactors one being the reactor IPEN/MB-01. The aim of this work is to develop a preliminary plan for decommissioning of nuclear reactor research, considering the technical documentation of the system (RAS-Safety Analysis Report), the existing rules of CNEN (National Nuclear Energy Commission), as well as regulatory instructions and recommendations of the IAEA. The preliminary decommissioning plan consists of the presentation of actions and steps required as well as the strategies to be adopted for the shutdown of the facility under the technical and administrative, seeking the safety, health workers and the general public, minimizing environmental impacts. (author)

  1. Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.

    Science.gov (United States)

    Macdonald, Lynn E; Karow, Margaret; Stevens, Sean; Auerbach, Wojtek; Poueymirou, William T; Yasenchak, Jason; Frendewey, David; Valenzuela, David M; Giallourakis, Cosmas C; Alt, Frederick W; Yancopoulos, George D; Murphy, Andrew J

    2014-04-08

    Genetic humanization, which involves replacing mouse genes with their human counterparts, can create powerful animal models for the study of human genes and diseases. One important example of genetic humanization involves mice humanized for their Ig genes, allowing for human antibody responses within a mouse background (HumAb mice) and also providing a valuable platform for the generation of fully human antibodies as therapeutics. However, existing HumAb mice do not have fully functional immune systems, perhaps because of the manner in which they were genetically humanized. Heretofore, most genetic humanizations have involved disruption of the endogenous mouse gene with simultaneous introduction of a human transgene at a new and random location (so-called KO-plus-transgenic humanization). More recent efforts have attempted to replace mouse genes with their human counterparts at the same genetic location (in situ humanization), but such efforts involved laborious procedures and were limited in size and precision. We describe a general and efficient method for very large, in situ, and precise genetic humanization using large compound bacterial artificial chromosome-based targeting vectors introduced into mouse ES cells. We applied this method to genetically humanize 3-Mb segments of both the mouse heavy and κ light chain Ig loci, by far the largest genetic humanizations ever described. This paper provides a detailed description of our genetic humanization approach, and the companion paper reports that the humoral immune systems of mice bearing these genetically humanized loci function as efficiently as those of WT mice.

  2. A 3.1-4.8 GHz CMOS receiver for MB-OFDM UWB

    International Nuclear Information System (INIS)

    Yang Guang; Yao Wang; Yin Jiangwei; Zheng Renliang; Li Wei; Li Ning; Ren Junyan

    2009-01-01

    An integrated fully differential ultra-wideband CMOS receiver for 3.1-4.8 GHz MB-OFDM systems is presented. A gain controllable low noise amplifier and a merged quadrature mixer are integrated as the RF front-end. Five order Gm-C type low pass filters and VGAs are also integrated for both I and Q IF paths in the receiver. The ESD protected chip is fabricated in a Jazz 0.18 μm RF CMOS process and achieves a maximum total voltage gain of 65 dB, an AGC range of 45 dB with about 6 dB/step, an averaged total noise figure of 6.4 to 8.8 dB over 3 bands and an in-band IIP3 of -5.1 dBm. The receiver occupies 2.3 mm 2 and consumes 110 mA from a 1.8 V supply including test buffers and a digital module.

  3. A 3.1-4.8 GHz CMOS receiver for MB-OFDM UWB

    Energy Technology Data Exchange (ETDEWEB)

    Yang Guang; Yao Wang; Yin Jiangwei; Zheng Renliang; Li Wei; Li Ning; Ren Junyan, E-mail: w-li@fudan.edu.c [State Key Laboratory of ASIC and System, Fudan University, Shanghai 201203 (China)

    2009-01-15

    An integrated fully differential ultra-wideband CMOS receiver for 3.1-4.8 GHz MB-OFDM systems is presented. A gain controllable low noise amplifier and a merged quadrature mixer are integrated as the RF front-end. Five order Gm-C type low pass filters and VGAs are also integrated for both I and Q IF paths in the receiver. The ESD protected chip is fabricated in a Jazz 0.18 mum RF CMOS process and achieves a maximum total voltage gain of 65 dB, an AGC range of 45 dB with about 6 dB/step, an averaged total noise figure of 6.4 to 8.8 dB over 3 bands and an in-band IIP3 of -5.1 dBm. The receiver occupies 2.3 mm{sup 2} and consumes 110 mA from a 1.8 V supply including test buffers and a digital module.

  4. Out-of-core detectors experiments in IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Abe, Alfredo Y.; Fuga, Rinaldo; Mendonca, Arlindo Gilson; Moreira, Joao M.L.; Angioletto, Elcio; Fanaro, Leda Cristina C.B.; Jerez, Rogerio; Coelho, Paulo R. Pinto; Santos, Adimir dos; Silva, Graciete S. de A. e; Diniz, Ricardo

    2000-01-01

    In order to study the response of out-of-core detectors, 16 stainless steel plates, with 0.5 cm thickness, were placed at the core-reflector interface of the IPEN/MB-01 reactor. BF 3 , 10 B and Au foil detectors were localized beyond the stainless steel plates in 7 different positions, one of them outside the moderator tank of the reactor for simulating a true PWR out-of-core detector. Calculations were performed for comparison with the experimental results with the TORT code, a three-dimensional transport theory discrete ordinate code. The experiment model utilized 16 energy groups, X-Y Z geometry, S 16 discrete ordinates and P 3 cross-sections. The obtained results showed a good agreement between measured and calculated reaction rates in Au foils. The larger discrepancy occurred for the case with 16 stainless steel with a 2,2% deviation. For position 7, outside of the moderator tank, the neutron flux was so low that it could not active the Au foils for the reaction rate measurements. (author)

  5. Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Amanda L. Peterson

    2016-09-01

    Full Text Available Cancer cells often have dysregulated metabolism, which is largely characterized by the Warburg effect—an increase in glycolytic activity at the expense of oxidative phosphorylation—and increased glutamine utilization. Modern metabolomics tools offer an efficient means to investigate metabolism in cancer cells. Currently, a number of protocols have been described for harvesting adherent cells for metabolomics analysis, but the techniques vary greatly and they lack specificity to particular cancer cell lines with diverse metabolic and structural features. Here we present an optimized method for untargeted metabolomics characterization of MDA-MB-231 triple negative breast cancer cells, which are commonly used to study metastatic breast cancer. We found that an approach that extracted all metabolites in a single step within the culture dish optimally detected both polar and non-polar metabolite classes with higher relative abundance than methods that involved removal of cells from the dish. We show that this method is highly suited to diverse applications, including the characterization of central metabolic flux by stable isotope labelling and differential analysis of cells subjected to specific pharmacological interventions.

  6. [Knock-down of BCL11A expression in breast cancer cells promotes MDA-MB-231 cell apoptosis].

    Science.gov (United States)

    Li, Hongli; Gui, Chen; Yan, Lijun

    2016-11-01

    Objective To detect the expression and pathological significance of B-cell CLL/lymphoma 11A (BCL11A) in breast cancer and investigate the effect of its silencing on the apoptosis of human MDA-MB-231 breast cancer cells. MethodsImmunohistochemistry was used to detect the expression of BCL11A in 62 cases of human breast cancer tissues and 8 cases of normal tissues. We synthesized siRNA targeting BCL11A, and then siRNA was transfected into MDA-MB-231 cells. Forty-eight hours later, the suppression effect of siRNA on BCL11A was determined by quantitative real-time PCR and Western blotting. The apoptosis of MDA-MB-231 cells was detected by flow cytometry. Results The BCL11A protein was mainly expressed in cytoplasm. The expression level of BCL11A in breast cancer tissues was higher than that in paracancerous tissues. The expression had correlations with tumor grade, tumor stage, while it had no correlations with the patients' age and tumor size. BCL11A-siRNA significantly suppressed the expression of BCL11A mRNA and protein as compared with the control group. MDA-MB-231 cells transfected with BCL11A-siRNA had higher apoptosis rate compared with the control group. Conclusion The BCL11A protein is highly expressed in breast cancer and knock-down of BCL11A promotes the apoptosis of MDA-MB-231 cells.

  7. Differentiating Canada: The Future of the Canada-US Relationship

    Directory of Open Access Journals (Sweden)

    Wendy Dobson

    2010-11-01

    Full Text Available Turbulence will mark the world economy in the coming decade as Canada’s traditional trading partners in North America and Europe struggle with slow growth and rising structural unemployment and move, as they must, to restore the health of their public finances. Settling for the status quo is not a compelling option as the US border thickens and Canada stays on the sidelines in two areas vital to its long-term interest: climate change policy and trade liberalization. In this context, the Policy Brief evaluates the strategic options for Canada’s long-standing economic relationship with the United States. The authors propose a two-part proactive strategy. The first part is for Canada to differentiate its economy by building on its macroeconomic, financial and energy strengths relative to the United States and by shaping a best-practice North American climate change policy. The second part of the strategy is to deepen NAFTA by participating in the Trans-Pacific Partnership (TPP, a comprehensive, highquality FTA that has strategic attention of the US administration. Any country can join by accepting the agreement’s provisions. The TPP offers at least two strategic opportunities: a comprehensive negotiation in which Canada, the United States and Mexico could upgrade NAFTA and a way to diversify and deepen trade and investment liberalization with major economies in the Asia-Pacific region.

  8. PLLA-PEG-TCH-labeled bioactive molecule nanofibers for tissue engineering

    Directory of Open Access Journals (Sweden)

    Chen J

    2011-10-01

    Full Text Available Jun Chen1,2, Beth Zhou1–3, Qi Li1,2, Jun Ouyang4, Jiming Kong2,4,5, Wen Zhong3,6, Malcolm MQ Xing1,2,4,71Department of Mechanical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, MB, Canada; 2Manitoba Institute of Child Health, Winnipeg, MB, Canada; 3Department of Textile Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, MB, Canada; 4School of Basic Medical Science, Southern Medical University, Guangzhoug, China; 5Department of Human Anatomy and Cell Sciences, 6Department of Medical Microbiology, Faculty of Medicine, 7Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, MB, CanadaAbstract: By mimicking the native extracellular matrix, electrospun nanofibrous scaffolds (ENSs can provide both chemical and physical cues to modulate cell adherence and differentiation and to promote tissue regeneration while retaining bioresorbable and biocompatible properties. In this study, ENSs were developed to deliver multiple biomolecules by loading them into the core-sheath structure and/or by conjugating them to the nanofiber surfaces. In this work, poly(L-lactide-poly(ethylene glycol-NH2 and poly(L-lactide were emulsion electrospun into nanofibers with a core-sheath structure. A model drug, tetracycline hydrochloride, was loaded within the nanofibers. Amino and carboxyl reactive groups were then activated on the fiber surfaces using saturated water vapor exposure and base hydrolysis, respectively. These reactive groups allowed the surface of the ENS to be functionalized with two other bioactive molecules, fluorescein isothiocyanate- and rhodamine-labeled bovine serum albumins, which were used as model proteins. The ENSs were shown to retain their antimicrobial capacity after two functionalization reactions, indicating that multifunctional nanofibers can potentially be developed into functional wound dressings or periodontal membranes or used in more complicated

  9. Natural gas resources in Canada

    International Nuclear Information System (INIS)

    Meneley, R.A.

    2001-01-01

    Natural gas is an important component in many of the technologies aimed at reducing greenhouse gas emissions. In order to understand the role that natural gas can play, it is important to know how much may be present, where it is, when can it be accessed and at what cost. The Canadian Gas Potential Committee has completed its second report 'Natural Gas Potential in Canada - 2001' (CGPC, 2001). This comprehensive study of exploration plays in Canada addresses the two issues of 'how much may be present' and 'where is it'. The Report deals with both conventional gas and non-conventional gas. One hundred and seven Established Conventional Exploration Plays, where discoveries of gas exist, have been assessed in all of the sedimentary basins in Canada. In addition, where sufficient information was available, twelve Conceptual Exploration Plays, where no discoveries have been made, were assessed. Sixty-five other Conceptual Plays were described and qualitatively ranked. An experienced volunteer team of exploration professionals conducted assessments of undiscovered gas potential over a four-year period. The team used technical judgment, statistical techniques and a unique peer review process to make a comprehensive assessment of undiscovered gas potential and estimates of the size of individual undiscovered gas accumulations. The Committee assessed all gas in place in individual exploration plays. For Established Plays, estimates of Undiscovered Nominal Marketable Gas are based on the percentage of the gas in place that is marketable gas in the discovered pools in a play. Not all of the Nominal Marketable Gas will be available. Some underlies areas where exploration is not possible, such as parks, cities and other closed areas. Some will be held in gas pools that are too small to be economic and some of the pools will never be found. In some areas no production infrastructure will be available. Detailed studies of individual exploration plays and basins will be required

  10. Fusion energy and Canada's role

    International Nuclear Information System (INIS)

    Drolet, T.S.

    1992-01-01

    Fusion is the process of releasing energy from matter which occurs in our sun. Canada is contributing to the development of technology which will permit this process to be harnessed and made available on earth. The international effort has increased from a modest beginning in the 1950s to a level of approximately two billion dollars annually in the 1980s. The purpose of this booklet is to introduce the concept of fusion energy as a technology which should make an important addition to the mix of energy sources for our future. Through a co-ordinated approach, Canada has established several projects which will contribute significantly to the development of technologies in specific areas leading to opportunities now for Canadian industry in the international effort

  11. Environmental radioactivity in Canada 1986

    International Nuclear Information System (INIS)

    1987-01-01

    The radiological surveillance program of the Department of National Health and Welfare is conducted for the purpose of determining levels of environmental radioactivity in Canada and assessing the resulting population exposures. During 1986 the program was strongly influenced by radioactive fallout on Canada resulting from the Chernobyl nuclear reactor accident on April 26, 1986 in the Soviet Ukraine. The Environmental Radiation Hazards Division (ERHD) increased its frequency of analyses of environmental samples immediately following the accident. Interim screening limits for foodstuffs were developed. A measurement program for radioactivity in domestic and imported foods was implemented. The ERHD measurement program was supplemented by additional measurements conducted by many other private and government laboratories. Radiation doses to Canadian from Chernobyl fallout were extremely low with no group in the population receiving more than 10 microsieverts

  12. Nuclear criticality safety in Canada

    International Nuclear Information System (INIS)

    Shultz, K.R.

    1980-04-01

    The approach taken to nuclear criticality safety in Canada has been influenced by the historical development of participants. The roles played by governmental agencies and private industry since the Atomic Energy Control Act was passed into Canadian Law in 1946 are outlined to set the scene for the current situation and directions that may be taken in the future. Nuclear criticality safety puts emphasis on the control of materials called special fissionable material in Canada. A brief account is given of the historical development and philosophy underlying the existing regulations governing special fissionable material. Subsequent events have led to a change in emphasis in the regulatory process that has not yet been fully integrated into Canadian legislation and regulations. Current efforts towards further development of regulations governing the practice of nuclear criticality safety are described. (auth)

  13. Canada: The largest uranium producer

    International Nuclear Information System (INIS)

    Lowell, A.F.

    1985-01-01

    Despite all the current difficulties, previous erroneous forecasts and other mistakes, the longer term future looks good for uranium mining and for Canada's industry in particular. Saskatchewan continues to offer the most exciting new prospects, the huge and fabulously high grade Cigar Lake deposits being the most spectacular of the recent discoveries. Notwithstanding continuous mining for 30 years from Elliot Lake there still remain there significant uncommitted reserves which can be developed when the market for uranium is in better balance

  14. Electric power in Canada, 1990

    International Nuclear Information System (INIS)

    1991-01-01

    This report reviews the structure of the electric power industry in Canada, describes the regulatory structures that are in place, and puts the Canadian electricity industry into an international context. It presents statistics on electricity generation and consumption, imports and exports, transmission, costs and pricing, and financing. It forecasts anticipated energy demands, generating capacity and actual generation, exports, fuel requirements, and expenditures. The impacts of demand-side management and non-utility generation are discussed. (82 tabs., 23 figs.)

  15. Electric power in Canada, 1989

    International Nuclear Information System (INIS)

    1991-01-01

    This report reviews the structure of the electric power industry in Canada, describes the regulatory structures that are in place, and puts the Canadian electricity industry into an international context. It presents statistics on electricity generation and consumption, imports and exports, transmission, costs and pricing, and financing. It forecasts anticipated energy demands, generating capacity and actual generation, exports, fuel requirements, and expenditures. The impacts of demand-side management and non-utility generation are discussed. (78 tabs., 27 figs.)

  16. Canada's family violence initiative: partnerships

    OpenAIRE

    Scott,Elaine

    1994-01-01

    Under Canada's four-year, $136 million Family Violence Initiative, the federal government is calling upon all Canadians to work in partnerships towards the elimination of family violence - child abuse, violence against women, and elder (senior) abuse. Family violence is a complex problem and requires the efforts of all Canadians to resolve it. One of the key themes of the Initiative - a multidisciplinary approach to the problem of family violence - is reflected in the selection and developmen...

  17. The nuclear debate in Canada

    International Nuclear Information System (INIS)

    Macaulay, H.L.

    1981-06-01

    The author argues that the nuclear debate in Canada is concerned less with the safety of nuclear power plants and more with arguments of economics and social decision-making. The nuclear industry cannot afford to neglect the continuing need to inform the public about nuclear risks. But there is also a need to develop specific arguments to increase public acceptance of nuclear energy as an economic, democratic and equitable energy option

  18. Canada; Financial Sector Stability Assessment

    OpenAIRE

    International Monetary Fund

    2014-01-01

    This report discusses key findings of the Financial Sector Stability Assessment on Canada. Canada’s financial system successfully navigated the global financial crisis, and stress tests suggest that major financial institutions would continue to be resilient to credit, liquidity, and contagion risks arising from a severe stress scenario. Elevated housing prices and high household debt remain an area of concern, though targeted prudential and macroprudential measures are proving to be effectiv...

  19. Overview of Canada's uranium industry

    International Nuclear Information System (INIS)

    Lowell, A.F.

    1982-06-01

    This paper places Canada's uranium industry in its international context. Most uranium, except that produced in the United States, is traded internationally. A brief history of the industry worldwide is given to show how the principal producing areas have fared to date. The industry is young, highly cyclical, and still far from achieving stability. Uranium is a single end-use commodity, entirely dependent on the generation of electricity in nuclear stations, and is without price elasticity: lowering the price does not increase demand. The typical nuclear fuel processing chain has not encouraged or led to much vertical integration. Uranium is subject to more governmental control than any other commodity. The principal market is located in the industrial countries of western Europe, the United States, Canada, and the far east. The uranium supply-demand situation is reviewed, including the current and near-term oversupply and the longer term outlook to 1995. The major negative impact of reactor cancellations and deferments in the United States is discussed. Because of the difficulty in getting reactors on line, it has become easier to forecast the demand for uranium over the next 10 years. It is more difficult to predict how that demand will be met from the more than ample competing sources. Canada's potential for supplying a significant portion of this demand is considered in relation to producers and potential new producers in other countries

  20. Women in Physics in Canada

    Science.gov (United States)

    McKenna, Janis

    2012-10-01

    Here we are in the 21st century in Canada, where most of us would say that young girls and boys have equal access to education, opportunities, and careers of their own choice. In Canada, women currently outnumber men in full-time university enrollment, in Medical Schools and in Law Schools. 48% of the Canadian work force is female, yet women make up only 21% of working professionals in science, engineering and technology. Canada-wide in Physics, the situation is such that only 20% of our BSc graduates are women, and 19% of our PhD graduates are women. It is evident that the ``leaky pipeline'' in Physics leaks most at a young age, before BSc graduation. High school physics statistics in BC indicate that while most of the grade 12 science and math disciplines have roughly equal numbers of young men and women enrolled, this is not the case for high school physics, where province-wide, only 30% of Physics 12 students are women. (Biology is also skewed, but in the other direction: 62% of Biology 12 students are women) This poster will present current statistics and will hopefully be a wake-up call for us all to consider participating in more outreach in science, and especially physics, in our high schools.

  1. Natural gas potential in Canada

    International Nuclear Information System (INIS)

    1997-01-01

    An independent assessment of the undiscovered gas potential in Canada was conducted by a group of volunteer geoscientists. This report is the first of a series of assessments that are planned to be issued every three to four years. Separate assessments were made of conventional gas resources, unconventional gas resources and frontier gas resources. The assessment for conventional gas resources was organized into three categories: (1) gas producing areas where new discoveries can be integrated into existing producing and transportation infrastructure, (2) frontier basins where gas discoveries have been made, but no production is currently underway, and (3) frontier areas where gas-containing sedimentary rocks are known to exist, but where no gas discoveries have been made to date. The committee used year-end 1993 reserves data from discovered pools in each exploration play to predict the undiscovered potential. Information about discovered pools, geological setting, geographic limits and pool sizes of undiscovered pools in each exploration play was provided. Results of the investigation led to the conclusion that the natural gas potential in Canada is in fact larger than hitherto expected. It was estimated that in the Western Canada Sedimentary Basin 47 per cent of the total volume of conventional gas is yet to be discovered. 152 figs

  2. Canada's helium output rising fast

    Energy Technology Data Exchange (ETDEWEB)

    1966-12-01

    About 12 months from now, International Helium Limited will be almost ready to start up Canada's second helium extraction plant at Mankota, in Saskatchewan's Wood Mountain area about 100 miles southwest of Moose Jaw. Another 80 miles north is Saskatchewan's (and Canada's) first helium plant, operated by Canadian Helium and sitting on a gas deposit at Wilhelm, 9 miles north of Swift Current. It contains almost 2% helium, some COD2U, and the rest nitrogen. One year in production was apparently enough to convince Canadian Helium that the export market (it sells most of its helium in W. Europe) can take a lot more than it's getting. Construction began this summer on an addition to the Swift Current plant that will raise its capacity from 12 to 36MMcf per yr when it goes on stream next spring. Six months later, International Helium's 40 MMcf per yr plant to be located about 4 miles from its 2 Wood Mountain wells will double Canada's helium output again.

  3. Indigenous Educational Attainment in Canada

    Directory of Open Access Journals (Sweden)

    Catherine E. Gordon

    2014-06-01

    Full Text Available In this article, the educational attainment of Indigenous peoples of working age (25 to 64 years in Canada is examined. This diverse population has typically had lower educational levels than the general population in Canada. Results indicate that, while on the positive side there are a greater number of highly educated Indigenous peoples, there is also a continuing gap between Indigenous and non-Indigenous peoples. Data also indicate that the proportion with less than high school education declined, which corresponds with a rise of those with a PSE; the reverse was true in 1996. Despite these gains, however, the large and increasing absolute numbers of those without a high school education is alarming. There are intra-Indigenous differences: First Nations with Indian Status and the Inuit are not doing as well as non-Status and Métis peoples. Comparisons between the Indigenous and non-Indigenous populations reveal that the documented gap in post-secondary educational attainment is at best stagnant. Out of the data analysis, and based on the history of educational policy, we comment on the current reform proposed by the Government of Canada, announced in February of 2014, and propose several policy recommendations to move educational attainment forward.

  4. MB109 as bioactive human bone morphogenetic protein-9 refolded and purified from E. coli inclusion bodies

    Science.gov (United States)

    2014-01-01

    Background The development of chemical refolding of transforming growth factor-beta (TGF-β) superfamily ligands has been instrumental to produce the recombinant proteins for biochemical studies and exploring the potential of protein therapeutics. The osteogenic human bone morphogenetic protein-2 (hBMP-2) and its Drosophila DPP homolog were the early successful cases of refolding into functional form. Despite the similarity in their three dimensional structure and amino acid sequences, several other TGF-β superfamily ligands could not be refolded readily by the same methods. Results Here, we report a comprehensive study on the variables of a rapid-dilution refolding method, including the concentrations of protein, salt, detergent and redox agents, pH, refolding duration and the presence of aggregation suppressors and host-cell contaminants, in order to identify the optimal condition to refold human BMP-9 (hBMP-9). To produce a recombinant form of hBMP-9 in E. coli cells, a synthetic codon-optimized gene was designed to encode the mature domain of hBMP-9 (Ser320 – Arg429) directly behind the first methionine, which we herein referred to as MB109. An effective purification scheme was also developed to purify the refolded MB109 to homogeneity with a final yield of 7.8 mg from 100 mg of chromatography-purified inclusion bodies as a starting material. The chemically refolded MB109 binds to ALK1, ActRIIb and BMPRII receptors with relatively high affinity as compared to other Type I and Type II receptors based on surface plasmon resonance analysis. Smad1-dependent luciferase assay in C2C12 cells shows that the MB109 has an EC50 of 0.61 ng/mL (25 pM), which is nearly the same as hBMP-9. Conclusion MB109 is prone to be refolded as non-functional dimer and higher order multimers in most of the conditions tested, but bioactive MB109 dimer can be refolded with high efficiency in a narrow window, which is strongly dependent on the pH, refolding duration, the presence of

  5. A de novo 1.58 Mb deletion, including MAP2K6 and mapping 1.28 Mb upstream to SOX9, identified in a patient with Pierre Robin sequence and osteopenia with multiple fractures.

    Science.gov (United States)

    Smyk, Marta; Roeder, Elizabeth; Cheung, Sau Wai; Szafranski, Przemyslaw; Stankiewicz, Paweł

    2015-08-01

    Defects of long-range regulatory elements of dosage-sensitive genes represent an under-recognized mechanism underlying genetic diseases. Haploinsufficiency of SOX9, the gene essential for development of testes and differentiation of chondrocytes, results in campomelic dysplasia, a skeletal malformation syndrome often associated with sex reversal. Chromosomal rearrangements with breakpoints mapping up to 1.6 Mb up- and downstream to SOX9, and disrupting its distant cis-regulatory elements, have been described in patients with milder forms of campomelic dysplasia, Pierre Robin sequence, and sex reversal. We present an ∼1.58 Mb deletion mapping ∼1.28 Mb upstream to SOX9 that encompasses its putative long-range cis-regulatory element(s) and MAP2K6 in a patient with Pierre Robin sequence and osteopenia with multiple fractures. Low bone mass panel testing using massively parallel sequencing of 23 nuclear genes, including COL1A1 and COL1A2 was negative. Based on the previous mouse model of Map2k6, suggesting that Sox9 is likely a downstream target of the p38 MAPK pathway, and our previous chromosome conformation capture-on-chip (4C) data showing potential interactions between SOX9 promoter and MAP2K6, we hypothesize that deletion of MAP2K6 might have affected SOX9 expression and contributed to our patient's phenotype. © 2015 Wiley Periodicals, Inc.

  6. Molecular Beam-Thermal Desorption Spectrometry (MB-TDS Monitoring of Hydrogen Desorbed from Storage Fuel Cell Anodes

    Directory of Open Access Journals (Sweden)

    Jorge H. F. Ribeiro

    2012-02-01

    Full Text Available Different types of experimental studies are performed using the hydrogen storage alloy (HSA MlNi3.6Co0.85Al0.3Mn0.3 (Ml: La-rich mischmetal, chemically surface treated, as the anode active material for application in a proton exchange membrane fuel cell (PEMFC. The recently developed molecular beam—thermal desorption spectrometry (MB-TDS technique is here reported for detecting the electrochemical hydrogen uptake and release by the treated HSA. The MB-TDS allows an accurate determination of the hydrogen mass absorbed into the hydrogen storage alloy (HSA, and has significant advantages in comparison with the conventional TDS method. Experimental data has revealed that the membrane electrode assembly (MEA using such chemically treated alloy presents an enhanced surface capability for hydrogen adsorption.

  7. PEA3 activates CXCR4 transcription in MDA-MB-231 and MCF7 breast cancer cells

    Institute of Scientific and Technical Information of China (English)

    Shengmei Gu; Li Chen; Qi Hong; Tingting Yan; Zhigang Zhuang; Qiaoqiao wang; Wei Jin; Hua Zhu; Jiong Wu

    2011-01-01

    CXC chemokine receptor 4 (CXCR4) is a cell surface receptor that has been shown to mediate the metastasis of many solid tumors including lung,breast,kidney,and prostate tumors.In this study,we found that overexpression of ets variant gene 4 (PEA3) could elevate CXCR4 mRNA level and CXCR4 promoter activity in human MDA-MB-231 and MCF-7 breast cancer cells.PEA3 promoted CXCR4 expression and breast cancer metastasis.Chromatin immunoprecipitation assay demonstrated that PEA3 could bind to the CXCR4 promoter in the cells transfected with PEA3 expression vector.PEA3 siRNA attenuated CXCR4 promoter activity and the binding of PEA3 to the CXCR4 promoter in MDA-MB-231 and MCF-7 cells.These results indicated that PEA3 could activate CXCR4 promoter transcription and promote breast cancer metastasis.

  8. PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy

    Science.gov (United States)

    Weng, Yuanqi; Yan, Fei; Chen, Runkang; Qian, Ming; Ou, Yun; Xie, Shuhong; Zheng, Hairong; Li, Jiangyu

    2018-05-01

    Mechanical stimuli drives many physiological processes through mechanically activated channels, and the recent discovery of PIEZO channel has generated great interests in its mechanotransduction. Many previous researches investigated PIEZO proteins by transcribing them in cells that originally have no response to mechanical stimulation, or by forming PIEZO-combined complexes in vitro, and few studied PIEZO protein's natural characteristics in cells. In this study we show that MDA-MB-231, a malignant cell in human breast cancer cell line, expresses the mechanosensitive behavior of PIEZO in nature without extra treatment, and we report its characteristics in response to localized mechanical stimulation under an atomic force microscope, wherein a correlation between the force magnitude applied and the channel opening probability is observed. The results on PIEZO of MDA-MB-231 can help establish a basis of preventing and controlling of human breast cancer cell via mechanical forces.

  9. Comparison between moving bed-membrane bioreactor (MB-MBR) and membrane bioreactor (MBR) systems: influence of wastewater salinity variation.

    Science.gov (United States)

    Di Trapani, Daniele; Di Bella, Gaetano; Mannina, Giorgio; Torregrossa, Michele; Viviani, Gaspare

    2014-06-01

    Two pilot plant systems were investigated for the treatment of wastewater subject to a gradual increase of salinity. In particular, a membrane bioreactor (MBR) and a moving bed biofilm membrane bioreactor (MB-MBR) were analyzed. Carbon and ammonium removal, kinetic constants and membranes fouling rates have been assessed. Both plants showed very high efficiency in terms of carbon and ammonium removal and the gradual salinity increase led to a good acclimation of the biomass, as confirmed by the respirometric tests. Significant biofilm detachments from carriers were experienced, which contributed to increase the irreversible superficial cake deposition. However, this aspect prevented the pore fouling tendency in the membrane module of MB-MBR system. On the contrary, the MBR pilot, even showing a lower irreversible cake deposition, was characterized by a higher pore fouling tendency. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Measure of thermal neutron flux in the IPEN/MB-01 reactor using 197 Au wire activation detectors

    International Nuclear Information System (INIS)

    Marques, Andre Luis Ferreira

    1995-01-01

    This dissertation has aimed at developing a neutron flux measurement technique by means of detectors activation analysis. The main task of this work was the implementation of this thermal neutron flux measurement technique, using gold wires as activation detectors in the IPEN/MB-01 reactor core. The neutron thermal flux spatial distribution was obtained by gold wire activation technique, with wire diameters of 0.125 mm and 0.250 mm in seven selected reactor experimental channels. The values of thermal flux were about 10 9 neutrons/cm 2 .s. This experiment has been the first one conducted with gold wires in the IPEN/MB-01 reactor, being this technique implemented for use by experiments in flux mapping of the core

  11. Molecular Beam-Thermal Desorption Spectrometry (MB-TDS) Monitoring of Hydrogen Desorbed from Storage Fuel Cell Anodes.

    Science.gov (United States)

    Lobo, Rui F M; Santos, Diogo M F; Sequeira, Cesar A C; Ribeiro, Jorge H F

    2012-02-06

    Different types of experimental studies are performed using the hydrogen storage alloy (HSA) MlNi 3.6 Co 0.85 Al 0.3 Mn 0.3 (Ml: La-rich mischmetal), chemically surface treated, as the anode active material for application in a proton exchange membrane fuel cell (PEMFC). The recently developed molecular beam-thermal desorption spectrometry (MB-TDS) technique is here reported for detecting the electrochemical hydrogen uptake and release by the treated HSA. The MB-TDS allows an accurate determination of the hydrogen mass absorbed into the hydrogen storage alloy (HSA), and has significant advantages in comparison with the conventional TDS method. Experimental data has revealed that the membrane electrode assembly (MEA) using such chemically treated alloy presents an enhanced surface capability for hydrogen adsorption.

  12. Regulation of MDA-MB-231 cell proliferation by GSK-3β involves epigenetic modifications under high glucose conditions

    International Nuclear Information System (INIS)

    Gupta, Chanchal; Kaur, Jasmine; Tikoo, Kulbhushan

    2014-01-01

    Hyperglycemia is a critical risk factor for development and progression of breast cancer. We have recently reported that high glucose induces phosphorylation of histone H3 at Ser 10 as well as de-phosphorylation of GSK-3β at Ser 9 in MDA-MB-231 cells. Here, we elucidate the mechanism underlying hyperglycemia-induced proliferation in MDA-MB-231 breast cancer cells. We provide evidence that hyperglycemia led to increased DNA methylation and DNMT1 expression in MDA-MB-231 cells. High glucose condition led to significant increase in the expression of PCNA, cyclin D1 and decrease in the expression of PTPN 12, p21 and PTEN. It also induced hypermethylation of DNA at the promoter region of PTPN 12, whereas hypomethylation at Vimentin and Snail. Silencing of GSK-3β by siRNA prevented histone H3 phosphorylation and reduced DNMT1 expression. We show that chromatin obtained after immunoprecipitation with phospho-histone H3 was hypermethylated under high glucose condition, which indicates a cross-talk between DNA methylation and histone H3 phosphorylation. ChIP-qPCR analysis revealed up-regulation of DNMT1 and metastatic genes viz. Vimentin, Snail and MMP-7 by phospho-histone H3, which were down-regulated upon GSK-3β silencing. To the best of our knowledge, this is the first report which shows that interplay between GSK-3β activation, histone H3 phosphorylation and DNA methylation directs proliferation of breast cancer cells. - Highlights: • High glucose induces phosphorylation of histone H3 and dephosphorylation of GSK-3β. • Moreover, hyperglycemia also leads to increased DNA methylation in MDA-MB-231 cells. • Inhibition of GSK-3β prevented histone H3 phosphorylation and reduced DNMT1 levels. • Interplay exists between GSK-3β, histone H3 phosphorylation and DNA methylation

  13. Validation the methodology calculate critical position of control rods to the critical facility IPEN/MB-01

    International Nuclear Information System (INIS)

    Lopez Aldama, D.; Rodriguez Gual, R.

    1998-01-01

    Presently work intends to validate the models and programs used in the Nuclear Technology Center for calculating the critical position of control rods by means of the analysis of the measurements performed at the critical facility IPEN/MB-01. The lattice calculations were carried out with the WIMS/D4 code and for the global calculations the diffusion code SNAP-3D was used

  14. Regulation of MDA-MB-231 cell proliferation by GSK-3β involves epigenetic modifications under high glucose conditions

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Chanchal; Kaur, Jasmine; Tikoo, Kulbhushan, E-mail: tikoo.k@gmail.com

    2014-05-15

    Hyperglycemia is a critical risk factor for development and progression of breast cancer. We have recently reported that high glucose induces phosphorylation of histone H3 at Ser 10 as well as de-phosphorylation of GSK-3β at Ser 9 in MDA-MB-231 cells. Here, we elucidate the mechanism underlying hyperglycemia-induced proliferation in MDA-MB-231 breast cancer cells. We provide evidence that hyperglycemia led to increased DNA methylation and DNMT1 expression in MDA-MB-231 cells. High glucose condition led to significant increase in the expression of PCNA, cyclin D1 and decrease in the expression of PTPN 12, p21 and PTEN. It also induced hypermethylation of DNA at the promoter region of PTPN 12, whereas hypomethylation at Vimentin and Snail. Silencing of GSK-3β by siRNA prevented histone H3 phosphorylation and reduced DNMT1 expression. We show that chromatin obtained after immunoprecipitation with phospho-histone H3 was hypermethylated under high glucose condition, which indicates a cross-talk between DNA methylation and histone H3 phosphorylation. ChIP-qPCR analysis revealed up-regulation of DNMT1 and metastatic genes viz. Vimentin, Snail and MMP-7 by phospho-histone H3, which were down-regulated upon GSK-3β silencing. To the best of our knowledge, this is the first report which shows that interplay between GSK-3β activation, histone H3 phosphorylation and DNA methylation directs proliferation of breast cancer cells. - Highlights: • High glucose induces phosphorylation of histone H3 and dephosphorylation of GSK-3β. • Moreover, hyperglycemia also leads to increased DNA methylation in MDA-MB-231 cells. • Inhibition of GSK-3β prevented histone H3 phosphorylation and reduced DNMT1 levels. • Interplay exists between GSK-3β, histone H3 phosphorylation and DNA methylation.

  15. Measurement of β/Λ ratio and calibration of IPEN-MB-01 power reactor using the noise technique

    International Nuclear Information System (INIS)

    Martins, F.R.; Moreira, J.M.L.

    1989-01-01

    The ratio β/Λ and power level for the IPEN-MB-01 critical facility are obtained experimentally through the noise analysis technique. This techniques is based on the determination of the auto and cross-power spectral density of two ionization chambers. The power measurement results obtained for channels 5 and 6 are shown in Table 2. For an effective neutron fraction of 0.00788 a prompt mean generation time of 65 microseconds was obtained. (author) [pt

  16. Suicide policy in Canada: lessons from history.

    Science.gov (United States)

    Spiwak, Rae; Elias, Brenda; Bolton, James M; Martens, Patricia J; Sareen, Jitender

    2012-07-18

    In Canada, suicide has transitioned from being a criminal activity with much associated stigma, to being a public health concern that needs to be managed by governments and clinicians in a culturally sensitive manner. In Canada and worldwide, the social attitudes toward and legal interpretation of suicide have been dynamic. Much has been proposed in the development of suicide policy in Canada, however Canada is unique in that it remains one of the only industrialized countries without a national suicide prevention strategy. The current article provides a critical review of the history of suicide in Canada, as well as an appraisal of Canadian suicide prevention policies and key government and political milestones that have impacted suicide policy. Current activity regarding a national suicide prevention strategy in Canada is discussed, as well as potential options for clinician involvement.

  17. Cytotoxic effect of sanguiin H-6 on MCF-7 and MDA-MB-231 human breast carcinoma cells.

    Science.gov (United States)

    Park, Eun-Ji; Lee, Dahae; Baek, Seon-Eun; Kim, Ki Hyun; Kang, Ki Sung; Jang, Tae Su; Lee, Hye Lim; Song, Ji Hoon; Yoo, Jeong-Eun

    2017-09-15

    Sanguiin H-6 is a dimer of casuarictin linked by a bond between the gallic acid residue and one of the hexahydroxydiphenic acid units. It is an effective compound extracted from Rubus coreanus. It has an anticancer effect against several human cancer cells; however, its effect on breast cancer cells has not been clearly demonstrated. Thus, we aimed to investigate the anticancer effect and mechanism of action of sanguiin H-6 against two human breast carcinoma cell lines (MCF-7 and MDA-MB-231). We found that sanguiin H-6 significantly reduced cell viability in a concentration-dependent manner. It also increased the rates at which MCF-7 and MDA-MB-231 cells underwent apoptosis. Furthermore, sanguiin H-6 induced the cleavage of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, which resulted in apoptosis. However, cleavage of caspase-9 was only detectable in MCF-7 cells. In addition, sanguiin H-6 increased the ratio of Bax to Bcl-2 in both MCF-7 and MDA-MB-231 cells. These findings suggest that sanguiin H-6 is a potent therapeutic agent against breast cancer cells. In addition, it exerts its anticancer effect in an estrogen-receptor-independent manner. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Analysis of Protein–Protein Interactions in MCF-7 and MDA-MB-231 Cell Lines Using Phthalic Acid Chemical

    Directory of Open Access Journals (Sweden)

    Shih-Shin Liang

    2014-11-01

    Full Text Available Phthalates are a class of plasticizers that have been characterized as endocrine disrupters, and are associated with genital diseases, cardiotoxicity, hepatotoxicity, and nephrotoxicity in the GeneOntology gene/protein database. In this study, we synthesized phthalic acid chemical probes and demonstrated differing protein–protein interactions between MCF-7 cells and MDA-MB-231 breast cancer cell lines. Phthalic acid chemical probes were synthesized using silicon dioxide particle carriers, which were modified using the silanized linker 3-aminopropyl triethoxyslane (APTES. Incubation with cell lysates from breast cancer cell lines revealed interactions between phthalic acid and cellular proteins in MCF-7 and MDA-MB-231 cells. Subsequent proteomics analyses indicated 22 phthalic acid-binding proteins in both cell types, including heat shock cognate 71-kDa protein, ATP synthase subunit beta, and heat shock protein HSP 90-beta. In addition, 21 MCF-7-specific and 32 MDA-MB-231 specific phthalic acid-binding proteins were identified, including related proteasome proteins, heat shock 70-kDa protein, and NADPH dehydrogenase and ribosomal correlated proteins, ras-related proteins, and members of the heat shock protein family, respectively.

  19. Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells

    Directory of Open Access Journals (Sweden)

    Hongzhuan Xuan

    2014-01-01

    Full Text Available Chinese propolis has been reported to possess various biological activities such as antitumor. In present study, anticancer activity of ethanol extract of Chinese propolis (EECP at 25, 50, 100, and 200 μg/mL was explored by testing the cytotoxicity in MCF-7 (human breast cancer ER(+ and MDA-MB-231 (human breast cancer ER(− cells. EECP revealed a dose- and time-dependent cytotoxic effect. Furthermore, annexin A7 (ANXA7, p53, nuclear factor-κB p65 (NF-κB p65, reactive oxygen species (ROS levels, and mitochondrial membrane potential were investigated. Our data indicated that treatment of EECP for 24 and 48 h induced both cells apoptosis obviously. Exposure to EECP significantly increased ANXA7 expression and ROS level, and NF-κB p65 level and mitochondrial membrane potential were depressed by EECP dramatically. The effects of EECP on p53 level were different in MCF-7 and MDA-MB-231 cells, which indicated that EECP exerted its antitumor effects in MCF-7 and MDA-MB-231 cells by inducing apoptosis, regulating the levels of ANXA7, p53, and NF-κB p65, upregulating intracellular ROS, and decreasing mitochondrial membrane potential. Interestingly, EECP had little or small cytotoxicity on normal human umbilical vein endothelial cells (HUVECs. These results suggest that EECP is a potential alternative agent on breast cancer treatment.

  20. Analysis of DNA restriction fragments greater than 5.7 Mb in size from the centromeric region of human chromosomes.

    Science.gov (United States)

    Arn, P H; Li, X; Smith, C; Hsu, M; Schwartz, D C; Jabs, E W

    1991-01-01

    Pulsed electrophoresis was used to study the organization of the human centromeric region. Genomic DNA was digested with rare-cutting enzymes. DNA fragments from 0.2 to greater than 5.7 Mb were separated by electrophoresis and hybridized with alphoid and simple DNA repeats. Rare-cutting enzymes (Mlu I, Nar I, Not I, Nru I, Sal I, Sfi I, Sst II) demonstrated fewer restriction sites at centromeric regions than elsewhere in the genome. The enzyme Not I had the fewest restriction sites at centromeric regions. As much as 70% of these sequences from the centromeric region are present in Not I DNA fragments greater than 5.7 and estimated to be as large as 10 Mb in size. Other repetitive sequences such as short interspersed repeated segments (SINEs), long interspersed repeated segments (LINEs), ribosomal DNA, and mini-satellite DNA that are not enriched at the centromeric region, are not enriched in Not I fragments of greater than 5.7 Mb in size.

  1. Canada's green plan: Summary. Le plan vert du Canada: Resume

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    A summary is presented of Canada's Green Plan, a comprehensive action plan to ensure a healthy environment for the future. The plan defines targets and schedules which will drive federal environmental initiatives, and incorporates concepts of sustainable development. Elements of the plan include initiatives to combat and prevent water pollution; control ocean dumping; control smog-causing emissions; provide tighter air pollution standards; provide for sound waste management according to the principles of reduce, reuse, recycle, and recover; assess and control chemical wastes; sustain Canadian forests and maintain their diversity while shifting forest management from sustained yield to sustainable development; maintain and enhance environmental sustainability in the agro-food sector and the fishery sector; preserve and protect national parks and wildlife; and preserve and enhance the integrity, health, biodiversity and productivity of Arctic ecosystems. With respect to global-scale problems, measures will be taken to stabilize greenhouse gas emissions, limit acid rain-related emissions, and phase out the use of ozone-depleting substances. The plan also intends to improve Canada's capability to respond to environmental emergencies, improve environmental decision-making by strengthening and building of partnerships, promote environmental science research and development, and make effective and balanced use of enviromental laws, with market-based approaches for environmental protection.

  2. Canada.

    Science.gov (United States)

    2008-10-13

    Recruitment drive for nurse gradutates British Columbia (BC), the westernmost Canadian province, urgently needs 1,500 qualified nurses graduates to staff longterm care and assisted-living beds as well as home care clients. The provincial government has launched a $160,000 (£78,600) marketing campaign called BC Cares. Craig Hebert, dean of development and access training at Northern Lights College in BC, said: 'The industry needs to get the message out to students that there has never been a better time to start a career in senior health care. Graduates who study for about one year, sometimes less, will have their pick of jobs in a number of service environments and can advance relatively quickly to the nursing profession.'

  3. Landfill gas management in Canada

    International Nuclear Information System (INIS)

    David, A.

    1997-01-01

    Landfill gas produced from solid waste landfills is one of the most significant sources of anthropogenic methane in Canada. Methane, a potent greenhouse gas, is 24.5 times more powerful than carbon dioxide by weight in terms of global climate change. Landfill gas recovery plays an important role in Canada's commitment to stabilize greenhouse gas emissions at 1990 levels by the year 2000 under the United Nations Framework Convention on Climate Change. Landfill gas is a potentially harmful emission that can be converted into a reliable environmentally-sustainable energy source used to generate electricity, fuel industries and heat buildings. The recovery and utilization of landfill gas is a win-win situation which makes good sense from local, regional and global perspectives. It provides the benefits of (1) reducing the release of greenhouse gases that contribute to global warming; (2) limiting odors; (3) controlling damage to vegetation; (4) reducing risks from explosions, fires and asphyxiation; (5) converting a harmful emission into a reliable energy source; and (6) creating a potential source of revenue and profit. Canadian landfills generate about 1 million tons of methane every year; the equivalent energy of 9 million barrels of oil (eight oil super tankers), or enough energy to meet the annual heating needs of more than half a million Canadian homes. Currently, twenty-seven facilities recover and combust roughly 25% of the methane generated by Canadian landfills producing about 3.2 PJ (10 15 Joules) of energy including 80 MW of electricity and direct fuel for nearby facilities (e.g., cement plants, gypsum board manufacturers, recycling facilities, greenhouses). This paper reviews landfill gas characteristics; environmental, health and safety impacts; landfill gas management in Canada; the costs of landfill gas recovery and utilization systems; and on-going projects on landfill gas utilization and flaring

  4. Integrating hydrogen into Canada's energy future

    International Nuclear Information System (INIS)

    Rivard, P.

    2006-01-01

    This presentation outlines the steps in integrating of hydrogen into Canada's energy future. Canada's hydrogen and fuel cell investment is primarily driven by two government commitments - climate change commitments and innovation leadership commitments. Canada's leading hydrogen and fuel cell industry is viewed as a long-term player in meeting the above commitments. A hydrogen and fuel cell national strategy is being jointly developed to create 'Win-Wins' with industry

  5. CHILD WELFARE IN CANADA : PART II

    OpenAIRE

    松本, 眞一; Shinichi, Matsumoto; 桃山学院大学社会学部

    2006-01-01

    This part study aims to research on the whole aspect of child protection in Canada. And so, this paper consists of five chapters as follows: (1)Canadian history of child protection, (2)definition of child abuse, (3)current situation of child protection in Canada, (4)outline of child protection and treatment, (5)triangular comparison of child protection and prevention in Canada, Australia and England. The first efforts at identifying and combating child abuse occurred in the latter part of the...

  6. Fusion energy. What Canada can do

    International Nuclear Information System (INIS)

    Weller, J.A.

    1988-01-01

    As Canada's fusion programs have grown, Canadian capabilities in fusion science and technology have grown and matured with them. The fusion capabilities described in this booklet have come from a coordinated national effort. The Government of Canada is committed to continuing its fusion energy program, and to supporting global fusion efforts. These first pages provide an overview of Canada's fusion work and its underlying basis of science and technology

  7. Environmental radioactivity in Canada 1987

    International Nuclear Information System (INIS)

    1988-01-01

    The radiological surveillance program of the Department of National Health and Welfare is conducted for the purpose of determining levels of environmental radioactivity in Canada and assessing the resulting population exposures. A study was initiated to evaluate the contamination by cesium-137, of caribou, a major source of food in northern communities. Work on development of methods proceeded for the determination of radon, carbon-14, polonium-210, radium-228 and isotopic uranium in samples. Monitoring continued of fallout contamination from Chernobyl of imported foods. All measurements made during 1987 are below the limits recommended by the International Commission on Radiological Protection

  8. An Energy Strategy for Canada

    Directory of Open Access Journals (Sweden)

    Michal C. Moore

    2015-10-01

    Full Text Available Canada is struggling to fully develop, sell and move its energy resources. This is a dramatic change from the recent past where the U.S. has provided stable growth in demand for energy supplied by the provinces, from hydrocarbons to electricity. Current circumstances now challenge this relationship, adding environmental, policy and economic hurdles that exacerbate the impact of fluctuations in world demand and pricing. In addition, competitive interaction between provinces, aboriginal land owners and special interest groups complicate and compound the issues of royalty returns, regulatory authority and direction, land-use management and long-term market opportunities for Canadian companies. There is no strategic document guiding the country’s energy future. As the steward of one of the largest, most diverse and valuable energy "banks" in the world, Canada has a unique opportunity to exploit a critical and valuable economic niche in the world economy. Given the lack of federal leadership and the tendency for each province to undercut each other in the same marketplace, there is also the distinct possibility the nation will squander the opportunity. This document offers the rationale for a comprehensive energy strategy, literally a vision where Canada can lead and not follow opportunities in energy markets. This strategic approach to energy systems by definition will include transportation, housing, employment and financial markets. It is not a plan, not a foil for tax or policy guidance in one or more sectors. This strategy is a fundamental rail on which plans, tactics and policies can be built. This vision identifies how the provinces can work together using all the tools available to them, maximizing long-term resource development while minimizing environmental damage. This document assumes there can be a broad commitment and effort by the federal government to help build those tools, providing guidance and assistance where needed without

  9. Radionuclides in Canada goose eggs

    International Nuclear Information System (INIS)

    Rickard, W.H.; Sweany, H.A.

    1975-01-01

    Low levels of radionuclides were measured in Canada goose eggs taken from deserted nests from Columbia River islands on the Energy Research and Development Administration's Hanford Reservation. Potassium-40, a naturally occurring radionuclide, was the most abundant radionuclide measured in egg contents and egg shell. Strontium-90 was incorporated into egg shells and cesium-137 into inner egg contents. Manganese-54, cobalt-60, and zinc-65 were more abundant in inner egg contents than in egg shell. Cerium-144 was detected in egg shell but not in inner shell

  10. Environmental radioactivity in Canada - 1982

    International Nuclear Information System (INIS)

    Tracey, B.L.

    1984-01-01

    The radiological surveillance program of the Department of National Health and Welfare is conducted for the purpose of determining levels of environmental radioactivity in Canada and assessing the resulting population exposures. Special investigations were carried out during 1982 on metabolism of natural radionuclides and on the accumulation of radon in energy-efficient homes. The pre-operational phase of the monitoring program at the Point Lepreau Nuclear Generating Station was completed. Dose commitments have been estimated for the ongoing natural radioactivity, fallout and reactor studies. All measurements made during the year are below the limits recommended by the International Commission on Radiological Protection

  11. Environmental radioactivity in Canada, 1981

    International Nuclear Information System (INIS)

    McGregor, R.G.; Quinn, J.M.; Tracy, B.L.

    1983-01-01

    The radiological surveillance program of the Department of National Health and Welfare is conducted for the purpose of determining levels of environmental radioactivity in Canada and assessing the resulting population exposures. Special investigations were carried out during 1981 on bottled mineral waters and in conjunction with unusual occurences at nuclear reactor sites and a uranium refinery. Dose commitments have been estimated for the ongoing natural radioactivity, fallout and reactor studies. All measurements made during the year are below the limits recommended by the International Commission on Radiological Protection

  12. Radioactive waste mangement in Canada

    International Nuclear Information System (INIS)

    Didyk, J.P.

    1976-01-01

    The objectives of the Canadian radioactive waste management program are to manage the wastes so that the potential hazards of the material are minimized, and to manage the wastes in a manner which places the minimum possible burden on future generations. The Atomic Energy Control Board regulates all activities in the nuclear field in Canada, including radioactive waste management facility licensing. The Atomic Energy Control Act authorizes the Board to make rules for regulating its proceedings and the performance of its functions. The Atomic Energy Control Regulations define basic regulatory requirements for the licensing of facilities, equipment and materials, including requirements for records and inspection, for security and for health and safety

  13. Canada's family violence initiative: partnerships

    Directory of Open Access Journals (Sweden)

    Elaine Scott

    1994-01-01

    Full Text Available Under Canada's four-year, $136 million Family Violence Initiative, the federal government is calling upon all Canadians to work in partnerships towards the elimination of family violence - child abuse, violence against women, and elder (senior abuse. Family violence is a complex problem and requires the efforts of all Canadians to resolve it. One of the key themes of the Initiative - a multidisciplinary approach to the problem of family violence - is reflected in the selection and development of projects. Activities funded by the seven federal departments and agencies involved in the Initiative emphasize partnerships with the professional, voluntary, corporate, non-government and government sectors.

  14. Environmental radioactivity in Canada, 1980

    International Nuclear Information System (INIS)

    McGregor, R.G.; Meyerhof, D.P.; Quinn, J.M.; Tracy, B.L.

    1983-01-01

    The radiological surveillance program of the Department of National Health and Welfare is conducted to determine levels of environmental radioactivity in Canada and asessing the resulting population exposures. In this report, the results for 1980 from the analyses of air, precipitation, water vapour, drinking water, milk, biota and bone for critical radionuclides are presented. The graphical format is used with extensions of the trend-lines to enable identification of changes in the levels and assessment of their potential health significance. All the levels measured during this period are below the permissible limits recommended by the International Commission for Radiological Protection

  15. NPP construction cost in Canada

    International Nuclear Information System (INIS)

    Gorshkov, A.L.

    1988-01-01

    The structure of capital costs during NPP construction in Canada is considered. Capital costs comprise direct costs (cost of the ground and ground rights, infrastructure, reactor equipment, turbogenerators, electrotechnical equipment, auxiliary equipment), indirect costs (construction equipment and services, engineering works and management services, insurance payments, freight, training, operating expenditures), capital per cents for the period of construction and cost of heavy water storages. It proceeds from the analysis of the construction cost structure for a NPP with the CANDU reactor of unit power of 515, 740 and 880 MW, that direct costs make up on the average 62%

  16. Critical energy infrastructure protection in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Gendron, Angela [Canadian Centre for Intelligence and Security Studies, Carleton University (Canada)

    2010-12-15

    In Canada government acknowledged the need to protect energy assets against attacks. However, so far no strategy has been developed. The aim of this report is to present the characteristics of the energy sector in Canada, the threats, and how the government is responding to those threats. The energy sector in Canada is concentrated and diverse and is under not only terrorism or cyber attacks threats but also environmental threats. This report shows that the Government of Canada is focusing on the protection and assurance of important energy infrastructures but that they are facing several challenges resulting in long delays in the adoption of a formal strategy.

  17. Canada Education Savings Program: Annual Statistical Review 2012

    Science.gov (United States)

    Human Resources and Skills Development Canada, 2012

    2012-01-01

    The Canada Education Savings Program (CESP) has been an initiative of the Government of Canada since 1998. As part of the Department of Human Resources and Skills Development Canada, the program administers the Canada Education Savings Grant (CESG) and the Canada Learning Bond (CLB). These two initiatives help Canadian families save for a child's…

  18. Recently surveyed lakes in northern Manitoba and Saskatchewan, Canada: characteristics and critical loads of acidity

    Directory of Open Access Journals (Sweden)

    Isaac WONG

    2010-08-01

    Full Text Available Based on minimal information, lakes in the western Canadian provinces of Manitoba (MB and Saskatchewan (SK have long been considered unaffected by acid rain. However, emissions of acidifying pollutants from MB smelters and oil sand processing in Alberta (AB may pose a developing threat. Surveys of 347 lakes located on geologically sensitive terrain in northern MB and SK were conducted to assess their acidification sensitivity and status. The survey domain (~193,000 km2 contained 81,494 lakes ≥1 ha in area. Small lakes dominated the inventory in terms of numbers, and large lakes dominated in terms of area. Survey lakes were selected using a stratified-random sampling design in 10 sampling blocks within the overall survey domain. Few lakes had pH <6, and only three (all in SK were acidic, i.e., Gran Alkalinity (Alk <0 μeq L–1. A broad range in lake sensitivity was apparent, and very sensitive lakes (low specific conductance, base cations and Alk were present in all sampling blocks. Dissolved organic carbon (DOC was an important constituent of many lakes. Critical loads (CL of acidity calculated using the Steady-State Water Chemistry model (SSWC revealed extremely low 5th percentile values for every block (range 1.9 to 52.7 eq ha–1 y–1. Block CL exceedances calculated using estimated S and N deposition for 2002 ranged from 54.5 to 909 eq ha–1 y–1. The largest exceedances were for sampling blocks located near smelter sources or downwind of the oil sands. Lake chemistry revealed by our surveys was compared to others conducted both nearby and outside Canada.

  19. Nuclear emergency preparedness in Canada

    International Nuclear Information System (INIS)

    1993-03-01

    The preparedness of utilities and government agencies at various levels for dealing with nuclear emergencies occurring at nuclear reactors in Canada is reviewed and assessed. The review is centered on power reactors, but selected research reactors are included also. Emergency planning in the U.S.A., Germany and France, and international recommendations on emergency planning are reviewed to provide background and a basis for comparison. The findings are that Canadians are generally well protected by existing nuclear emergency plans at the electric utility and provincial levels but there are improvements that can be made, mainly at the federal level and in federal-provincial coordination. Ten issues of importance are identified: commitment to nuclear emergency planning by the federal government; division of federal and provincial roles and responsibilities; auditing of nuclear emergency preparedness of all levels of government and of electric utilities; the availability of technical guidance appropriate to Canada; protective action levels for public health and safety; communication with the public; planning and response for the later phases of a nuclear emergency; off-site exercises and training; coordination of international assistance; and emergency planning for research reactors. (L.L.) 79 refs., 2 tabs

  20. 2000 Western Canada activity forecast

    International Nuclear Information System (INIS)

    Kuntz, D.L.

    1999-10-01

    All wells drilled in Western Canada during the first nine months of 1999 are listed and sorted into 12 geographical areas used in the Petroleum Services Association of Canada (PSAC) well cost study. Each area represents wells of common drilling, production and depth characteristics. Area totals for well counts and meters drilled were determined from the sorting process. Previous years' activities are reviewed and various operators and PSAC members contacted to review upcoming programs. In addition, trends and other projections were consulted to develop an estimate of drilling activity for the rest of 1999 as well as a projection of drilling activity for 2000. The historical and projected drilling activities were tabulated and plotted for each area. Average drilling costs for each area were determined, and the total expenditures were calculated for each area by multiplying the the projected meterage by the adjusted drilling costs. All costs were allocated to various services and products utilizing percentages determined in the Well Cost Study. During the sorting process, a list was developed of the major operators in each area, which list is included in the report along with average depths and types of wells drilled by the various operators in each area. The costs included in the report include only drilling and completion operations, starting with the building of the location prior to drilling, and ending with the installation of the wellhead after construction. 5 tabs

  1. Natural background radiation in Canada

    International Nuclear Information System (INIS)

    Grasty, R.L.; Carson, J.M.; Charbonneau, B.W.; Holman, P.B.

    1984-01-01

    Published airborne gamma ray survey data from 33 areas of Canada were used to compile information on the average ground level exposure from natural radiation. The exposures at ground level were calculated from the surface concentrations of potassium, uranium and thorium. The highest levels of radioactivity were found in northern Canada and were generally related to granitic rocks; the lowest levels with the Athabasca sandstone. Summer outdoor exposure rates have a population-weighted average of 3.7 +- 2.3 μR.h -1 , of which 48 percent orginated from potassium, 43 percent from the thorium series and 9 percent from the uranium series. This low level of radioactivity, compared to worldwide data, has resulted from erosion of a geologically old continental crust in which radioactivity decreases with depth. When seasonal variations of soil moisture and snow cover are considered, the annual population-weighted average outdoor exposure rate decreases to 2.8 +- 1.7 μR.h -1 corresponding to an annual outdoor dose-equivalent of 150 +- 90 μSV. Factors increasing the annual outdoor dose-equivalent are cosmic radiation (320 +- 30 μSV) and the internal radioactivity of the body (190 μSV). Using the ratio between indoor and outdoor values for worldwide published data, the average annual Canadian whole-body dose-equivalent from all sources of natural radiation is estimated to be 690 +-130 μSV

  2. Eastern Canada natural gas developments

    International Nuclear Information System (INIS)

    Wall, A.

    2001-01-01

    This power point presentation addressed the following topics regarding development of natural gas in eastern Canada: (1) the 18 Tcf of proven natural gas reserves at Sable Island, (2) Canadian markets benefiting from the Maritimes and Northeast Pipeline (M and NP), (3) a 20 year franchise agreement between Enbridge Gas and the government of New Brunswick, (4) the 25 year provincial franchise agreement by Sempra Atlantic Gas, and (5) Sable Island's influence on central Canada. The Sable Offshore Energy Project (SOEP) is now producing about 540,000 MMBtu/day from 6 fields. Plans for Tier 2 expansion are underway. Firm contracts for the M and NP are scheduled to transport gas from the SOEP to markets in Nova Scotia, New Brunswick, Maine and New Hampshire. Sable gas is also a potential supply for the Quebec market. Gaz Metropolitain and Enbridge have proposed to build the Cartier Pipeline from the Quebec/New Brunswick border to Quebec City. It is unlikely that Sable Island supply will directly serve the Ontario market. Canadian customers for Sable gas and M and NP service include pulp and paper companies, oil refineries, power generators and local distribution companies (LDC), with the majority of demand coming form the electric power industry. tabs., figs

  3. Energy in Canada: An overview

    International Nuclear Information System (INIS)

    Cameron, G.W.

    1991-01-01

    Recent changes in the North American natural gas industry are discussed, with a focus on how these changes will affect the ability of Alberta and Canadian natural gas supply to meet market growth. These changes include a decline in the merchant role of many of the major interstate pipelines, resulting in a larger number of smaller-sized purchasers for natural gas marketers to deal with; a greater extent of direct purchasing by local distribution companies and large industrial users, combined with a preference for spot sales rather than long-term commitments; direct marketing of uncontracted gas by many producers and brokers; a bidding type of sales process rather than a negotiated process; and price deregulation. It is foreseen that long term security of supply will again become an important factor to North American buyers, and Canada can offer substantial supplies under secure long term contracts. Marketers will have to seek new market targets such as cogeneration plants and the transportation sector. Access to pipeline transport will be one of the major factors in obtaining new markets. The Canada-USA free trade agreement is viewed as a positive development which should help Canadian gas marketers to gain and retain U.S. customers

  4. Wind turbine supply in Canada

    International Nuclear Information System (INIS)

    Snodin, H.

    2007-01-01

    This study reported on wind turbine supplies to the Canadian market. The report was written to address concerns for Canada's supply outlook in the near future due to the booming wind energy market. Turbine shortages have arisen as a result of continued growth in both European and North American markets. Long lead-times on turbine orders are now increasing the pressure to lock in turbine supply during the initial phases of the development process. Future growth of the wind energy industry will be impacted if turbine supply difficulties continue to contribute to uncertainties in the development process. The report provided an overview of the North American and global wind energy markets, as well as a summary of telephone interviews conducted with turbine suppliers. The implications for the future of turbine supply to the Canadian market were also analyzed. It was concluded that policy-makers should focus on supporting the expansion of manufacturing facilities for small wind turbines and control infrastructure in Canada 7 refs., 3 figs

  5. Canada's forest biomass resources: deriving estimates from Canada's forest inventory

    International Nuclear Information System (INIS)

    Penner, M.; Power, K.; Muhairwe, C.; Tellier, R.; Wang, Y.

    1997-01-01

    A biomass inventory for Canada was undertaken to address the data needs of carbon budget modelers, specifically to provide estimates of above-ground tree components and of non-merchantable trees in Canadian forests. The objective was to produce a national method for converting volume estimates to biomass that was standardized, repeatable across the country, efficient and well documented. Different conversion methods were used for low productivity forests (productivity class 1) and higher productivity forests (productivity class 2). The conversion factors were computed by constructing hypothetical stands for each site, age, species and province combination, and estimating the merchantable volume and all the above-ground biomass components from suitable published equations. This report documents the procedures for deriving the national biomass inventory, and provides illustrative examples of the results. 46 refs., 9 tabs., 5 figs

  6. Open Educational Resources in Canada 2015

    Science.gov (United States)

    McGreal, Rory; Anderson, Terry; Conrad, Dianne

    2015-01-01

    Canada's important areas of expertise in open educational resources (OER) are beginning to be built upon or replicated more broadly in all education and training sectors. This paper provides an overview of the state of the art in OER initiatives and open higher education in general in Canada, providing insights into what is happening nationally…

  7. Cultural Dependency in Canada's Feature Film Industry.

    Science.gov (United States)

    Pendakur, Manjunath

    1981-01-01

    Examines the ownership and policies of the dominant firms in the Canadian film market to explain Canada's dependence on imported films. Demonstrates how the economic relations existing between Canadian and U.S. film industries limit the profitability of films made in Canada. (JMF)

  8. Professor: Lær af Canada

    DEFF Research Database (Denmark)

    Greve, Carsten

    2013-01-01

    Transportdebatten: En mulig finansiering af fremtidige infrastrukturprojekter kunne være OPP. Danmark bør tage ved lære af erfaringer fra Canada.......Transportdebatten: En mulig finansiering af fremtidige infrastrukturprojekter kunne være OPP. Danmark bør tage ved lære af erfaringer fra Canada....

  9. ABR-based newborn hearing screening with MB11 BERAphone® using an optimized chirp for acoustical stimulation.

    Science.gov (United States)

    Cebulla, Mario; Shehata-Dieler, Wafaa

    2012-04-01

    At our center, the Maico MB11 BERAphone(®) device is used for newborn hearing screening based on Auditory Brainstem Responses (ABR). In 2006, an optimized chirp stimulus was implemented in the device to increase the reliability and quality of the screening method. In 2002, an automated response detection algorithm had been implemented. This study analyzes the screening results using the MB11 BERAphone(®) device with the implemented chirp stimulus and automated response detection method. The data presented were collected in the well-baby nursery as part of the newborn hearing screening program following a two stage screening protocol. To focus the study on the typical routine screening, data from at-risk babies were not included. Overall, data from 6866 babies (3604 males and 3262 females) screened from March 2006 to April 2011 were analyzed in this study. Out of the 6866 babies screened, 6607 passed bilaterally prior to hospital discharge (defined as 1st stage in this hearing screening program). Therefore, the pre-discharge pass rate of the hearing screening with the MB11 BERAphone(®) device was 96.2%. The resulting referral rate was 3.8%. The median test time per ear (excluding time for preparation and data reporting) was 28s with a range of 15-112s (5-95th percentile). The number of infants referred for 2nd stage, post-discharge re-screening was 259. Of this group, 71 passed bilaterally and 188 failed the re-screening in one or both ears. Therefore, including both the pre-discharge and post-discharge screening results, the bilateral pass rate was 97.3% and 2.7% were referred for diagnostic evaluation. Diagnostic testing was performed on all of the 188 infants who were referred. Results showed that 47 of these babies had hearing loss. This equates to a positive predictive value for a refer result of 25%. The observed prevalence of hearing impairment in our population was 0.684%. Diagnostic results for 141 of the referred newborns proved that they had normal

  10. Western Canada : changing pricing dynamics

    International Nuclear Information System (INIS)

    Frank, B.

    1998-01-01

    Natural gas supply and demand trends in Western Canada are reviewed in a series of overhead viewgraphs. Production versus pipeline capacity, required gas well completions in the WCSB to meet local demand and fill export pipeline capacity to year 2005, NYMEX and AECO price trends during 1995-2000, and the question of what will happen to prices with additional pipeline capacity to the U.S. Midwest were summarized. The best guess is that Midwest prices will need to be high enough to attract marginal supplies from the Gulf, i.e. prices have be around the Henry Hub + five cents/ mmbtu. The new Canadian pipelines, (Northern Border and Alliance) will lower Midwest prices somewhat, but the impact will be modest. Assuming that additional planned pipeline expansion come on-stream, the pressure to expand east of Chicago will be considerable. tabs., figs

  11. Student research in Canada's north

    Energy Technology Data Exchange (ETDEWEB)

    Admas, P [ed.; Johnson, P G [ed.

    1988-01-01

    A conference was organized in Canada to allow a large number of students with northern interests to meet together to present the results of their work and to discuss many other matters of mutual interset. In addition, this conference allowed students from many disciplines in the natural and social sciences to advance northern scholarship, and to foster a multidisciplinary approach to northern studies. A wide range of topics from the physical, biological, and social sciences were covered, including Inuit music, traditional medicine, mammoth bones, fossil trees, icebreaker design, archaeology, caves, naturally acid and other lakes, glaciers, bogs, Inuit clothing, education, northern parks, river ice jams, geology, marine science including large marine mammals, and global strategy. Separate abstracts have been prepared for twelve papers from this conference.

  12. Nuclear emergency exercises in Canada

    International Nuclear Information System (INIS)

    Ali, F.B.

    1993-01-01

    The practice followed in planning, preparing and conducting offsite nuclear emergency exercises in the Province of Ontario, Canada, is described. In addition, some of the main issues that arise during this process are discussed, as well as Canadian experience in dealing with them. The planning process starts with basic decisions on the aim, scope and duration of the exercise. It proceeds through selection of the exercise objectives and participants, the development of scenarios and incident lists culminating in a master scenario and a master incident list, and finally, the production of control inputs. Preparations include the setting up of a planning organization, making arrangements for exercise control and evaluation, and the required logistics. Some aspects of international exercises are also covered, based upon experience with joint exercises with the U.S.A

  13. Oil price uncertainty in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Elder, John [Department of Finance and Real Estate, 1272 Campus Delivery, Colorado State University, Fort Collins, CO 80523 (United States); Serletis, Apostolos [Department of Economics, University of Calgary, Calgary, Alberta (Canada)

    2009-11-15

    Bernanke [Bernanke, Ben S. Irreversibility, uncertainty, and cyclical investment. Quarterly Journal of Economics 98 (1983), 85-106.] shows how uncertainty about energy prices may induce optimizing firms to postpone investment decisions, thereby leading to a decline in aggregate output. Elder and Serletis [Elder, John and Serletis, Apostolos. Oil price uncertainty.] find empirical evidence that uncertainty about oil prices has tended to depress investment in the United States. In this paper we assess the robustness of these results by investigating the effects of oil price uncertainty in Canada. Our results are remarkably similar to existing results for the United States, providing additional evidence that uncertainty about oil prices may provide another explanation for why the sharp oil price declines of 1985 failed to produce rapid output growth. Impulse-response analysis suggests that uncertainty about oil prices may tend to reinforce the negative response of output to positive oil shocks. (author)

  14. What fusion means to Canada

    International Nuclear Information System (INIS)

    Bolton, R.A.

    1983-06-01

    Fusion can and will play an ever-increasing role in the energy balance once it has been brought on line. Taming of this technology and the maturing processes of engineering and economic feasibility will proceed at a rate which depends very strongly upon international and collective national wills to see it through. Large experimental devices, particularly of the tokamak type, are now being completed; their performance should give a very good idea of the scientific feasibility. The next-stage devices are at the pre-proposal and proposal stages but are not yet approved, even in principle. An improved general economic climate sustained for a few years would certainly help re-establish the momentum of world international efforts in fusion. This paper gives an overview of fusion research on a world scale and details of the particular aspects that Canada has chosen to pursue

  15. Climate change research in Canada

    International Nuclear Information System (INIS)

    Dawson, K.

    1994-01-01

    The current consensus on climatic change in Canada is briefly summarized, noting the results of modelling of the effects of a doubling of atmospheric CO 2 , the nonuniformity of climate change across the country, the uncertainties in local responses to change, and the general agreement that 2-4 degrees of warming will occur for each doubling of CO 2 . Canadian government response includes programs aimed at reducing the uncertainties in the scientific understanding of climate change and in the socio-economic response to such change. Canadian climate change programs include participation in large-scale experiments on such topics as heat transport in the ocean, and sources and sinks of greenhouse gases; development of next-generation climate models; studying the social and economic effects of climate change in the Great Lakes Basin and Mackenzie River Basin; investigation of paleoclimates; and analysis of climate data for long-term trends

  16. Focus: Asian migration to Canada.

    Science.gov (United States)

    Kobayashi, A

    1988-01-01

    This collection of 5 short essays on Asian migration to Canada focuses on the relationships between individual migrants and their social contexts, both Asian and Canadian. Papers by Anderson and Kobayashi adopt research perspectives of outsider and insider, respectively. Vibert provides a historical overview against which the substantive issues introduced in the other 3 papers can be understood, and he illustrates the links between circumstances of migration and the larger issues by which the course of Canadian social progress has been steered. Mercer provides an introduction to issues that dominate the agenda of contemporary research, to show that Canadian communities of Asian heritage continue to grow in size, diversity, and complexity, as they become more established on the Canadian landscape. This collection is as much about the geography of racism as it is about migration.

  17. Transport gasoline demand in Canada

    International Nuclear Information System (INIS)

    Eltony, M.N.

    1993-01-01

    This paper provides an estimate of household gasoline demand in Canada by applying a detailed model to pool time-series (1969-1988) and cross-sectional provincial data. The model recognises three major behavioural changes that households can make in response to gasoline price changes: drive fewer miles, purchase fewer cars, and buy more fuel-efficient vehicles. In the model, fuel economy is treated in considerable detail. The two components of the fuel economy of new cars sold-the technical fuel efficiency of various classes of cars and the distribution of new car sales according to their interior volume rather than their weight - are estimated as functions of economic variables. Car manufacturers are assumed to improve the technical fuel economy according to their expectation of consumer's response to future changes in gasoline prices and general economic conditions. (author)

  18. Restorative justice innovations in Canada.

    Science.gov (United States)

    Wilson, Robin J; Huculak, Bria; McWhinnie, Andrew

    2002-01-01

    As many jurisdictions move towards more retributive measures as a means to address public discontent with crime, a parallel movement has developed in regard to restorative justice. This article presents three restorative initiatives currently in use in Canada. Each initiative addresses offender behavior and community engagement at a different point in the justice continuum. The use of Sentencing Circles is an example of how restorative justice principles can be instituted at the front end, prior to an offender becoming lodged in the system. The Restorative Justice Options to Parole Suspension project demonstrates how community engagement can assist in preventing offenders from being returned to the system once they have achieved conditional release. The Circles of Support and Accountability project has enlisted the support of professionally supported volunteers in the community reintegration of high-risk sexual offenders. These initiatives are presented within a framework of effective correctional interventions and increased empowerment for a variety of stakeholders. Copyright 2002 John Wiley & Sons, Ltd.

  19. Environmental radioactivity in Canada 1988

    International Nuclear Information System (INIS)

    1991-01-01

    The radiological surveillance program of the Department of National Health and Welfare is conducted for the purpose of determining levels of environmental radioactivity in Canada and assessing the resulting population exposures. Following major changes to the CAMECO Port Hope operations to reduce uranium emissions, a study was initiated to measure uranium levels in air in the community. Studies continued on lung cancer and domestic exposure to radon, and current levels of cesium-137 in caribou, a major source of food in northern communities. The movement of tritium on the Ottawa and St. Lawrence rivers was studied following an accidental release into the Ottawa River. Monitoring continued of fallout contamination from Chernobyl in imported foods. All measurements recorded during 1988 were below the limits recommended by the International Commission on Radiological Protection. (14 refs., 14 figs., 15 tabs.)

  20. Canada's population: growth and dualism.

    Science.gov (United States)

    Beaujot, R P

    1978-04-01

    In Canada the current 1.3% population growth rate is causing some concern. Those concerned argue that such a rate of growth in combination with high levels of consumption could jeopardize the country's resource base and its comfortable style of living. Many Canadians are questioning high levels of immigration, for now that the fertility level is below replacement level, net immigration contributes substantially to population growth (over 1/3 in 1976). The growing proportion of non-Europeans among recent immigrants is causing resentment, and, in a tight job market, immigrants are regarded as threats to the World War 2 baby boom cohort who are now at working ages. The baby boom generation also puts stress on housing and health services, and it will increase the need for pension checks as it ages. Although French fertility is no longer high and immigration is no longer dominated by the British, the French group's 200-year struggle to preserve its identity continues on in the current effort of the Quebec government to enforce the use of French language by law within that province. Geography and climate dictate another demographic fact that divides the country and pervades its history. In addition to intense regionalism, uneven population distribution is responsible for 2 other concerns: the rapid growth of several already large cities and depopulation of many small communities. Focus in this discussion is on Canada's population growth in the past and as projected for the future, historical and current fertility, mortality and immigration trends, the search for a new immigration policy, the impact of the baby boom generation on the population's age structure and the problems this creates, and recent shifts in population distribution and in the country's ethnic and linguistic makeup. The population policy proposals evolved thus far involve to a great extent the use of immigration as a lever for achieving given population objectives.

  1. High coronary calcium score and post-procedural CK-MB are noninvasive predictors of coronary stent restenosis

    Directory of Open Access Journals (Sweden)

    Lee JB

    2017-02-01

    Full Text Available Jae-Beom Lee,1 Yun-Seok Choi,2 Woo-Baek Chung,2 Ami Kwon,2 Chul-Soo Park,2 Man-Young Lee2 1Anyang Sam Hospital, 2Division of Cardiology, Department of Internal Medicine, Youido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Purpose: High coronary calcium score (CCS and post-procedural cardiac enzyme may be related with poor outcomes in patients with coronary stent implantation. Methods: A total of 1,072 patients (63.2% male, mean age: 61.7±10.3 years who underwent coronary multi-detect computed tomography at index procedure and follow-up coronary angiography (CAG after drug-eluting stent (DES were divided into two groups: those with and without target lesion revascularization (TLR; >50% reduction in luminal stent diameter or angina symptoms on follow-up CAG. The CCSs for predicting stent revascularization were elucidated. Results: There were no significant differences between the two groups with regard to risk factors. The initial CCS was significantly higher in the TLR group (1,102.4±743.7 vs 345.8±51.05, P=0.04. After adjustment of significant factors for TLR, only CCS and post-procedural creatine kinase MB form (CK-MB elevation were significant predictors of coronary artery TLR. Receiver operation curve revealed that >800 in CCS had 69% in sensitivity and 88% in specificity about predicting the TLR. Conclusion: High CCS with post-procedural CK-MB might be the useful predictors for TLR after DES implantation. Keywords: coronary restenosis, drug-eluting stents, calcium, creatine kinase

  2. Physical and transcription map of a 25 Mb region on human chromosome 7 (region q21-q22)

    Energy Technology Data Exchange (ETDEWEB)

    Scherer, S. [Univ. of Toronto (Canada)]|[Hosptial for Sick Children, Toronto (Canada); Little, S.; Vandenberg, A. [Hospital for Sick Children, Toronto (Canada)] [and others

    1994-09-01

    We are interested in the q21-q22 region of chromosome 7 because of its implication in a number of diseases. This region of about 25 Mb appears to be involved in ectrodactyly/ectodermal dysplasia/cleft plate (EEC) and split hand/split foot deformity (SHFD1), as well as myelodysplastic syndrome and acute non-lymphocyte leukemia. In order to identify the genes responsible for these and other diseases, we have constructed a physical map of this region. The proximal and distal boundaries of the region were operationally defined by the microsatellite markers D7S660 and D7S692, which are about 35 cM apart. This region between these two markers could be divided into 13 intervals on the basis of chromosome breakpoints contained in somatic cell hybrids. The map positions for 43 additional microsatellite markers and 25 cloned genes were determined with respect to these intervals. A physical map based on contigs of over 250 YACs has also been assembled. While the contigs encompass all of the known genetic markers mapped to the region and almost cover the entire 25-Mb region, there are 3 gaps on the map. One of these gaps spans a set of DNA markers for which no corresponding YAC clones could be identified. To connect the two adjacent contigs we have initiated cosmid walking with a chromosome 7-specific library (Lawrence Livermore Laboratory). A tiling path of 60 contiguous YAC clones has been assembled and used for direct cDNA selection. Over 300 cDNA clones have been isolated and characterized. They are being grouped into transcription units by Northern blot analysis and screening of full-length cDNA libraries. Further, exon amplification and direct cDNA library screening with evolutionarily conserved sequences are being performed for a 1-Mb region spanning the SHFD1 locus to ensure detection of all transcribed sequences.

  3. Radio-sensitization by Piper longumine of human breast adenoma MDA-MB-231 cells in vitro.

    Science.gov (United States)

    Yao, Jian-Xin; Yao, Zhi-Feng; Li, Zhan-Feng; Liu, Yong-Biao

    2014-01-01

    The current study investigated the effects of Piper longumine on radio-sensitization of human breast cancer MDA-MB-231 cells and underlying mechanisms. Human breast cancer MDA-MB-231 cells were cultured in vitro and those in logarithmic growth phase were selected for experiments divided into four groups: control, X-ray exposed, Piper longumine, and Piper longumine combined with X-rays. Conogenic assays were performed to determine the radio-sensitizing effects. Cell survival curves were fitted by single-hit multi-target model and then the survival fraction (SF), average lethal dose (D0), quasi-threshold dose (Dq) and sensitive enhancement ratio (SER) were calculated. Cell apoptosis was analyzed by flow cytometry (FCM).Western blot assays were employed for expression of apoptosis-related proteins (Bc1-2 and Bax) after treatment with Piper longumine and/or X-ray radiation. The intracellular reactive oxygen species (ROS) level was detected by FCM with a DCFH-DA probe. The cloning formation capacity was decreased in the group of piperlongumine plus radiation, which displayed the values of SF2, D0, Dq significantly lower than those of radiation alone group and the sensitive enhancement ratio (SER) of D0 was1.22 and 1.29, respectively. The cell apoptosis rate was increased by the combination treatment of Piper longumine and radiation. Piper longumine increased the radiation-induced intracellular levels of ROS. Compared with the control group and individual group, the combination group demonstrated significantly decreased expression of Bcl-2 with increased Bax. Piper longumine at a non-cytotoxic concentration can enhance the radio-sensitivity of MDA- MB-231cells, which may be related to its regulation of apoptosis-related protein expression and the increase of intracellular ROS level, thus increasing radiation-induced apoptosis.

  4. Efficiency and safety of transfer of type 2 diabetes patients inadequately controlled on metformin alone to combined therapy with metformin and diabeton MB

    Directory of Open Access Journals (Sweden)

    Alexander Sergeevich Ametov

    2009-12-01

    Full Text Available Aim. To evaluate efficiency and tolerability of diabeton MB/metformin combination in patients failing to achieve optimal glycemic control when onmetformin monotherapy and prove advantages of this combination over combined low-dose therapy with glibenclamide and metformin. Materials and methods. The study included 464 patients with type 2 diabetes mellitus who poorly responded to metformin monotherapy. It was supplementedby diabeton MB. Efficiency and tolerability of combined treatment was evaluated from dynamics of glycemia and frequency of side-effects.40 patients were included in detailed comparative assessment (laboratory and instrumental, CGMS of this monotherapy and fixed low-dose combinationof glibenclamide with metformin. Results. Results of comparison show that diabeton MB/metformin combination ensured most optimal glycemic control with a minimal risk of side effects. Conclusion. Diabeton MB/metformin combination is convenient, efficient and safe.

  5. Clinical utility of a two-site immunoradiometric assay for creatine kinase-MB in the detection of perioperative myocardial infarction

    International Nuclear Information System (INIS)

    DePuey, E.G.; Aessopos, A.; Monroe, L.R.; Hall, R.J.; Thompson, W.L.; Sonnemaker, R.E.; Burdine, J.A.

    1983-01-01

    In 144 patients, creatine kinase MB was measured serially at 0, 8, 16, 24, 48 and 72 h using a two-site immunoradionmetric assay (IRMA). Cardiac enzymes were also measured, including SGOT, LDH, total CPK, and CK-MB by electrophoresis. The presence of perioperative myocardial infarction (poMI) was established in 24 patients by the appearance of new electrocardiographic Q waves and/or new wall motion abnormalities detected by radionuclide ventriculography. In patients without poMI, CK-MB (IRMA) was elevated at 0 to 8 h but decreased by 16 h. In patients with poMI, peak values occurred at 16 to 24 h. Using a threshold value of 8.5 EU/I, patients with poMI could be distinguished from those without with 97% accuracy (sensitivity = 88%, specificity = 99%). We conclude that the CK-MB (IRMA) can serve as a valuable postoperative screening tet for poMI

  6. Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts

    International Nuclear Information System (INIS)

    Peterson, Sarah M; Concino, Michael F; Liaw, Lucy; Martini, Paolo GV; Iskenderian, Andrea; Cook, Lynette; Romashko, Alla; Tobin, Kristen; Jones, Michael; Norton, Angela; Gómez-Yafal, Alicia; Heartlein, Michael W

    2010-01-01

    Extracellular human sulfatases modulate growth factor signaling by alteration of the heparin/heparan sulfate proteoglycan (HSPG) 6-O-sulfation state. HSPGs bind to numerous growth factor ligands including fibroblast growth factors (FGF), epidermal growth factors (EGF), and vascular endothelial growth factors (VEGF), and are critically important in the context of cancer cell growth, invasion, and metastasis. We hypothesized that sulfatase activity in the tumor microenvironment would regulate tumor growth in vivo. We established a model of stable expression of sulfatases in the human breast cancer cell line MDA-MB-231 and purified recombinant human Sulfatase 2 (rhSulf2) for exogenous administration. In vitro studies were performed to measure effects on breast cancer cell invasion and proliferation, and groups were statistically compared using Student's t-test. The effects of hSulf2 on tumor progression were tested using in vivo xenografts with two methods. First, MDA-MB-231 cells stably expressing hSulf1, hSulf2, or both hSulf1/hSulf2 were grown as xenografts and the resulting tumor growth and vascularization was compared to controls. Secondly, wild type MDA-MB-231 xenografts were treated by short-term intratumoral injection with rhSulf2 or vehicle during tumor growth. Ultrasound analysis was also used to complement caliper measurement to monitor tumor growth. In vivo studies were statistically analyzed using Student's t test. In vitro, stable expression of hSulf2 or administration of rhSulf2 in breast cancer cells decreased cell proliferation and invasion, corresponding to an inhibition of ERK activation. Stable expression of the sulfatases in xenografts significantly suppressed tumor growth, with complete regression of tumors expressing both hSulf1 and hSulf2 and significantly smaller tumor volumes in groups expressing hSulf1 or hSulf2 compared to control xenografts. Despite significant suppression of tumor volume, sulfatases did not affect vascular

  7. Neutron lifetimes behavior analysis considering the two-region kinetic model in the IPEN/MB-01 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Gonnelli, Eduardo; Diniz, Ricardo [Instituto de Pesquisas Energéticas e Nucleares - IPEN/CNEN-SP Travessa R-400, 05508-900, Cidade Universitária, São Paulo (Brazil)

    2014-11-11

    This is a complementary work about the behavior analysis of the neutron lifetimes that was developed in the IPEN/MB-01 nuclear reactor facility. The macroscopic neutron noise technique was experimentally employed using pulse mode detectors for two stages of control rods insertion, where a total of twenty levels of subcriticality have been carried out. It was also considered that the neutron reflector density was treated as an additional group of delayed neutrons, being a sophisticated approach in the two-region kinetic theoretical model.

  8. Neutron lifetimes behavior analysis considering the two-region kinetic model in the IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Gonnelli, Eduardo; Diniz, Ricardo

    2014-01-01

    This is a complementary work about the behavior analysis of the neutron lifetimes that was developed in the IPEN/MB-01 nuclear reactor facility. The macroscopic neutron noise technique was experimentally employed using pulse mode detectors for two stages of control rods insertion, where a total of twenty levels of subcriticality have been carried out. It was also considered that the neutron reflector density was treated as an additional group of delayed neutrons, being a sophisticated approach in the two-region kinetic theoretical model

  9. Flavokawain A induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro.

    Directory of Open Access Journals (Sweden)

    Nadiah Abu

    Full Text Available The kava-kava plant (Piper methsyticum is traditionally known as the pacific elixir by the pacific islanders for its role in a wide range of biological activities. The extract of the roots of this plant contains a variety of interesting molecules including Flavokawain A and this molecule is known to have anti-cancer properties. Breast cancer is still one of the leading diagnosed cancers in women today. The metastatic process is also very pertinent in the progression of tumorigenesis.MCF-7 and MDA-MB231 cells were treated with several concentrations of FKA. The apoptotic analysis was done through the MTT assay, BrdU assay, Annexin V analysis, cell cycle analysis, JC-1 mitochondrial dye, AO/PI dual staining, caspase 8/9 fluorometric assay, quantitative real time PCR and western blot. For the metastatic assays, the in vitro scratch assay, trans-well migration/invasion assay, HUVEC tube formation assay, ex vivo rat aortic ring assay, quantitative real time PCR and western blot were employed.We have investigated the effects of FKA on the apoptotic and metastatic process in two breast cancer cell lines. FKA induces apoptosis in both MCF-7 and MDA-MB231 in a dose dependent manner through the intrinsic mitochondrial pathway. Additionally, FKA selectively induces a G2/M arrest in the cell cycle machinery of MDA-MB231 and G1 arrest in MCF-7. This suggests that FKA's anti-cancer activity is dependent on the p53 status. Moreover, FKA also halted the migration and invasion process in MDA-MB231. The similar effects can be seen in the inhibition of the angiogenesis process as well.FKA managed to induce apoptosis and inhibit the metastatic process in two breast cancer cell lines, in vitro. Overall, FKA may serve as a promising candidate in the search of a new anti-cancer drug especially in halting the metastatic process but further in vivo evidence is needed.

  10. A 11.7-Mb Paracentric Inversion in Chromosome 1q Detected in Prenatal Diagnosis Associated with Familial Intellectual Disability.

    Science.gov (United States)

    Rigola, Maria A; Baena, Neus; Català, Vicenç; Lozano, Iris; Gabau, Elisabet; Guitart, Miriam; Fuster, Carmen

    2015-01-01

    Most apparent balanced chromosomal inversions are usually clinically asymptomatic; however, infertility, miscarriages, and mental retardation have been reported in inversion carriers. We present a small family with a paracentric inversion 1q42.13q43 detected in routine prenatal diagnosis. Molecular cytogenetic methods defined the size of the inversion as 11.7 Mb and excluded other unbalanced chromosomal alterations in the patients. Our findings suggest that intellectual disability is caused by dysfunction, disruption, or position effects of genes located at or near the breakpoints involved in this inversion. © 2015 S. Karger AG, Basel.

  11. The Effect of Histone Hyperacetylation on Viability of Basal-Like Breast Cancer Cells MDA-MB-231

    Directory of Open Access Journals (Sweden)

    Aliasghar Rahimian

    2017-06-01

    Full Text Available Background The Basal-Like breast cancer, is always known for lack of expression of estrogen receptor (ER, progesterone receptor (PR and as well, absence of epidermal growth factor receptor 2 (HER2 gene amplification. Improper expression pattern of ER, PR, and Her2, makes Basal-Like breast tumors resistant to the current hormonal and anti HER2 treatments. In recent decades, several studies have been conducted to investigate the regulatory role of chemical modifications of core histones in gene expression. Their results have shown that histone acetylation is involved in regulation of cell survival. Acetylation of core histones is regulated by the epigenetic-modifying enzymes named Histone Deacetylases (HDACs. As a new approach to control the viability of breast tumor cells resistant to the hormonal and anti-HER2 treatments, we have targeted the HDACs. Using Trichostatin A (TSA as a known HDACs inhibitor, we have tried to hyperacetylate the core histones of MDA-MB-231 cells as an in vitro model of Basal-Like breast tumors. Then we have investigated the effect of histone hyperacetylation on viability of MDA-MB-231 cells. Methods MDA-MB-231 cells were cultured in RPMI 1640 medium containing 10% fetal bovine serum (FBS and were incubated at 37°C, in a humidified incubator with 5% CO2 atmosphere. Then cells were treated with different concentrations of TSA including: 50, 100, 200, 400, 800 and 1000 nM or control (1% DMSO. After 24 and 48 hours, viability of cells was evaluated by MTT assay. Results After 24 and 48h exposure to different concentrations of TSA, MDA-MB-231 cells showed a maximum tolerable dose. At higher concentrations, TSA decreased the percentage of cell viability through a time-dose dependent manner. IC50 value for 48h treatment was 600 nM. Conclusions Our results indicate that HDACs inhibition and subsequently hyperacetylation of histones, leads to cytotoxic effects on breast tumor cells resistant to the current treatments. Following

  12. Decatropis bicolor (Zucc.) Radlk essential oil induces apoptosis of the MDA-MB-231 breast cancer cell line.

    Science.gov (United States)

    Estanislao Gómez, C C; Aquino Carreño, A; Pérez Ishiwara, D G; San Martín Martínez, E; Morales López, J; Pérez Hernández, N; Gómez García, M C

    2016-08-05

    Decatropis bicolor (Zucc.)Radlk is a plant that has been traditionally used for the treatment of breast cancer in some communities of Mexico. So, the aim of this study was to determine the cytotoxic and apoptotic effect of the essential oil of Decatropis bicolor against breast cancer cell line, MDA-MB-231. The essential oil obtained from hydrodestillation of leaves of Decatropis bicolor was studied for its biological activity against breast cancer cells MDA-MB-231 by MTT assay, Hematoxylin-eosin stain, Annexin V-FITC, TUNEL and western blot assays and for its chemical composition by GC-MS. The results showed a relevant cytotoxic effect of the essential oil towards MDA-MB-231 cells in a dose- and time- dependent manner, with an IC50 of 53.81 ± 1.691 μg/ml but not in the epithelial mammary cell line MCF10A (207.51 ± 3.26 μg/ml). Morphological examination displayed apoptotic characteristics in the treated cells like cell size reduction, membrane blebbing and apoptotic bodies. In addition, the apoptotic rate significantly increased as well as DNA fragmentation and western blot analysis revealed that the essential oil induced apoptosis in the MDA-MB-231 cells via intrinsic pathways due to the activation of Bax, caspases 9 and 3. Phytochemical analysis of the Decatropis bicolor essential oil showed the presence of twenty-three compounds. Major components of the oil were 1,5-cyclooctadiene,3-(methyl-2)propenyl (18.38 %), β-terpineol (8.16 %) and 1-(3-methyl-cyclopent-2-enyl)-cyclohexene (6.12 %). This study suggests that essential oil of Decatropis bicolor has a potential cytotoxic and antitumoral effect against breast cancer cells, with the presence of potential bioactive compounds. Our results contribute to the validation of the anticancer activity of the plant in Mexican traditional medicine.

  13. Demonstration of 575-Mb/s downlink and 225-Mb/s uplink bi-directional SCM-WDM visible light communication using RGB LED and phosphor-based LED.

    Science.gov (United States)

    Wang, Yuanquan; Wang, Yiguang; Chi, Nan; Yu, Jianjun; Shang, Huiliang

    2013-01-14

    We propose and experimentally demonstrate a novel full-duplex bi-directional subcarrier multiplexing (SCM)-wavelength division multiplexing (WDM) visible light communication (VLC) system based on commercially available red-green-blue (RGB) light emitting diode (LED) and phosphor-based LED (P-LED) with 575-Mb/s downstream and 225-Mb/s upstream transmission, employing various modulation orders of quadrature amplitude modulation (QAM) orthogonal frequency division multiplexing (OFDM). For the downlink, red and green colors/wavelengths are assigned to carry useful information, while blue chip is just kept lighting to maintain the white color illumination, and for the uplink, the low-cost P-LED is implemented. In this demonstration, pre-equalization and post-equalization are also adopted to compensate the severe frequency response of LEDs. Using this scheme, 4-user downlink and 1-user uplink transmission can be achieved. Furthermore, it can support more users by adjusting the bandwidth of each sub-channel. Bit error rates (BERs) of all links are below pre-forward-error-correction (pre-FEC) threshold of 3.8x 10(-3) after 66-cm free-space delivery. The results show that this scheme has great potential in the practical VLC system.

  14. The diagnostic value of both troponin T and creatinine kinase isoenzyme (CK-MB in detecting combined renal and myocardial injuries in asphyxiated infants.

    Directory of Open Access Journals (Sweden)

    Wilson E Sadoh

    Full Text Available Troponin T (cTnT and Creatinine Kinase Isoenzyme (CK-MB are both markers of myocardial injuries. However, CK-MB is also elevated in acute kidney injury.The diagnostic value of both cTnT and cardiac CK-MB in combined myocardial and acute kidney injuries (AKI in asphyxiated neonates was evaluated.40 asphyxiated infants and 40 non-asphyxiated controls were consecutively recruited. Serum levels of cTnT, CK-MB and creatinine were measured. Myocardial injury and AKI were defined as cTnT >95th percentile of the control and serum creatinine >1.0 mg/dl respectively.Of the 40 subjects, 9 (22.50%, 8 (20.00% and 4 (10.00% had myocardial injury, AKI and combined AKI and myocardial injuries respectively. The mean cTnT and CK-MB values were highest in infants with combined AKI and myocardial injuries. The Mean cTnT in infants with AKI, myocardial injury and combined AKI and myocardial injuries were 0.010±0.0007 ng/ml, 0.067±0.040 ng/ml and 0.084±0.067 ng/ml respectively, p = 0.006. The mean CK-MB in infants with AKI, myocardial injury and combined AKI and myocardial injuries were 2.78±0.22 ng/ml, 1.28±0.11 ng/ml and 4.58±0.52 ng/ml respectively, p = <0.0001.In severe perinatal asphyxia, renal and myocardial injuries could co-exist. Elevated cTnT signifies the presence of myocardial injury. Elevated CK-MB indicates either myocardial injury, AKI or both. Therefore renal injury should be excluded in asphyxiated infants with elevated CK-MB.

  15. Ármin Vámbéry (1832-1913 as a Historian of Early Hungarian Settlement in the Carpathian Basin

    Directory of Open Access Journals (Sweden)

    Nándor Dreisziger

    2016-01-01

    Full Text Available In the English-speaking world Ármin Vámbéry is known as a traveler in Central Asia and a student of Turkic cultures and languages. In his native Hungary he is also known for his disagreement with linguists who believed that Hungarian belonged to the Ugric branch of the Finno-Ugric languages—a part of the Uralic linguistic family. Rather than accepting this theory, Vámbéry contended that Hungarian was largely a Turkic language that belonged more to the Altaic family. Few people know that Vámbéry also expressed strong opinions about the genesis of the Hungarian nation. The most important aspect of Vámbéry’s theory about Hungarian origins is the thesis that Hungarian ethnogenesis took place—beginning with late Roman times or even earlier—in the Carpathian Basin. A corollary of this proposition is that the nomadic tribes that conquered the Carpathian Basin at the end of the ninth century were Turkic peoples who were few in numbers and were assimilated by the region’s autochthonous—and by then Hungarian-speaking—population. This paper outlines Vámbéry’s arguments and describes to what extent research on this subject in the century since Vámbéry’s death has confirmed or contradicted his unconventional ideas.

  16. Canada's nuclear non-proliferation policy

    International Nuclear Information System (INIS)

    1985-01-01

    Canada's non-proliferation and safeguards policy has two objectives: 1) to promote the emergence of a more effective and comprehensive international non-proliferation regime; and 2) to assure the Canadian people and the international community that Canadian nuclear exports will not be used for any nuclear explosive purpose. By emphasizing the key role of the NPT, by promoting reliance upon and improvements in the IAEA safeguards system, by treating nuclear weapon and non-nuclear weapon states alike regarding Canadian nuclear exports, by working for new approaches covering the sensitive phases (e.g. reprocessing) of the nuclear fuel cycle, Canada's policy promotes attainment of the first objective. The latter objective is served through the network of bilateral nuclear agreements that Canada has put into place with its nuclear partners. Those agreements provide assurance that Canada's nuclear exports are used solely for legitimate, peaceful, nuclear energy production purposes. At the same time, Canada, having formulated its non-proliferation and safeguards policy during the period 1945 to 1980, has recognized that it has gone as far as it can on its own in this field and that from this point on any further changes should be made on the basis of international agreement. The Canadian objective in post-INFCE forums such as the Committee on Assurances of Supply is to exert Canada's best efforts to persuade the international community to devise a more effective and comprehensive international non-proliferation regime into which Canada and other suppliers might subsume their national requirements

  17. Uranium in Canada: Billion-dollar industry

    International Nuclear Information System (INIS)

    Whillans, R.T.

    1989-01-01

    In 1988, Canada maintained its position as the world's leading producer and exporter of uranium; five primary uranium producers reported concentrate output containing 12,400 MT of uranium, or about one-third of Western production. Uranium shipments made by these producers in 1988 exceeded 13,200 MT, worth Canadian $1.1 billion. Because domestic requirements represent only 15% of current Canadian output, most of Canada's uranium production is available for export. Despite continued market uncertainty in 1988, Canada's uranium producers signed new sales contracts for some 14,000 MT, twice the 1987 level. About 90% of this new volume is with the US, now Canada's major uranium customer. The recent implementation of the Canada/US Free Trade agreement brings benefits to both countries; the uranium industries in each can now develop in an orderly, free market. Canada's uranium industry was restructured and consolidated in 1988 through merger and acquisition; three new uranium projects advanced significantly. Canada's new policy on nonresident ownership in the uranium mining sector, designed to encourage both Canadian and foreign investment, should greatly improve efforts to finance the development of recent Canadian uranium discoveries

  18. Taxi and limousine industry in Canada

    International Nuclear Information System (INIS)

    Monteiro, J.; Civettini, S.

    2007-01-01

    Taxi and limousine service plays an important role in the movement of people within a city. In 2004, the total revenue in this industry in Canada was $1.305 billion, and an estimated 35,339 carriers served the industry. In Canada, economic and safety regulations of taxi supply were imposed in most cities during the 1930s and 1940s and continue to this date. Although the industry is regulated, the competition law also applies. The appropriateness of these regulations continues to be challenged and regulatory reforms in the major cities in Canada have concentrated their efforts on increasing the rate of services, improving the quality of vehicles and enhancing the training of taxi drivers. Indicators for the 1999-2004 period reveal that the taxi and limousine industry in Canada did not perform very well. Revenue increased by only 1.7 per cent per year and margins deteriorated by -1.78 per cent together with the operating ratio. The purpose of this paper was to examine the taxi and limousine industry in Canada. First, the structure of the industry in Canada was examined followed by a review of the economic regulation of the industry. Recent regulatory developments in Canada and in other countries were then reviewed with arguments for or against deregulation. 28 refs., 2 tabs

  19. Petro-Canada 1997 annual report

    International Nuclear Information System (INIS)

    1998-01-01

    Petro-Canada is a dominant player in the petroleum industry in Western Canada as well as on the Grand Banks offshore Newfoundland. This report presents a review of operations, provides detailed statements of the corporation's finances, and a wealth of information of interest to shareholders. The report states that in 1997 Petro-Canada achieved record financial results, following a dramatic turnaround over the past five years. Net earnings for 1997 were $306 million, a $59 million increase over 1996. The company's share price appreciated 34 per cent in 1997 and was one of the most heavily traded stocks in Canada. The company plans to maximize shareholder value by reducing its interests in conventional oil from mature fields in western Canada and by re-investing the proceeds in natural gas development. Petro-Canada is also committed to an expansion that will double production at the Syncrude oil sands plant over the next decade and has tested large in-situ oil sands resources for potential development in northeastern Alberta. On the Atlantic coast too, Petro-Canada is delivering leadership with increasing production from Hibernia, and final approvals in place to proceed with development of the Terra Nova field. International operations are also contributing to the Corporation's profitability by delivering new production from oil fields offshore Norway and from the Sahara Desert in North Africa. tabs., figs

  20. Canada`s green plan and the earth summit

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    In June 1992 one of the largest international conferences ever held took place in Rio de Janeiro, Brazil. It was attended by the heads of state of more than 100 countries. The ambitious aim of the United Nations Conference on Environment and Development (UNCED) -- the Earth Summit -- was to try to reconcile the need for global environmental protection with the need for continuing economic development. The purpose of this document is to provide a brief account of the results of Rio and the way Canadians participated. In addition, this document outlines the immediate priorities of the Government of Canada and the actions under way. It is not meant to be a comprehensive response to the entire Rio agenda. Rather, it is intended to report to Canadians on the steps the government has taken so far and, where possible, the direction in which it is headed. On the number of important issues, the government`s plans are well advanced. For example, action is well under way on the Convention on Climate Change, as high-lighted in the Green Plan`s National Action Strategy on Global Warming. On a number of other issues, it is clear that there is work to be done. The government is committed to completing the task through continuing action and leadership.

  1. Buckling measurement in the IPEN/MB-01 nuclear reactor in cylindrical configuration of minor excess of reactivity

    Energy Technology Data Exchange (ETDEWEB)

    Purgato, Rafael Turrini; Bitelli, Ulysses d' Utra; Aredes, Vitor Ottoni; Silva, Alexandre F. Povoa da; Santos, Diogo Feliciano dos; Lima, Ana Cecilia de Souza, E-mail: ubitelli@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    This work presents the results of experimental Buckling in the IPEN/MB-01 nuclear reactor in its cylindrical configuration with 28 fuel rods along its diameter. The IPEN/MB-01 is a zero power reactor designed to operate at a maximum power of 100 watts. It is a versatile nuclear facility, which allows for the simulation of all the characteristics of a nuclear power reactor making it an ideal test bed for this kind of measurement. A mapping of neutron flux inside the reactor is carried out in order to determine the total Buckling of the cylindrical configuration. The reactor was operated for one hour. Then, the activity of the fuel rods is measured by gamma ray spectrometry using a HPGe solid state detector and a suitable rod scanner. Photon energies of 276.6keV from {sup 239}Np (neutron capture (n,?) nuclear reaction) and 293.3keV from {sup 143}Ce (fission (n,f) nuclear reaction on both {sup 238}U and {sup 235}U) , are respectively along both axial and radial directions. Other measurements are performed using gold wires and foils along radial and axial directions of the reactor core. The three methods above resulted in a weighted average value of 93.18 ± 8.47 m-2 for the Total Buckling of this cylindrical core configuration with 28 control rods along its diameter with 568 fuel rods and only 271 pcm of excess reactivity. (author)

  2. Effects of fish silage on growth and biochemical characteristics of fresh water microalga Scenedesmus sp. MB 23

    Directory of Open Access Journals (Sweden)

    Jasmin Kaippilliparambil Abdulsamad

    2017-08-01

    Full Text Available Scenedesmus sp. MB 23 was cultivated in fish silage to study the effects of different concentrations on the growth and biochemical characteristics, particularly the protein, carbohydrate and lipid properties. Fish silage with 12% concentration was most effective for the growth and biomass production of Scenedesmus sp. The microalga reached maximum cell density (2433.89 × 104 cells/mL, chlorophyll-a concentration (2.766 μg/mL, specific growth rate (0.48/d and biomass (2.73 g/L on this medium. In mass culture, enhanced production of protein (123.87 mg/g dry weight of alga, carbohydrate (44.904 mg/g dry weight of alga and lipid (84.21 mg/g dry weight of alga was found using 9% fish silage. The effective reduction (up to 90% in the concentrations of nitrate, phosphorus and ammonia in the final fish silage medium proved the removal efficiency of Scenedesmus sp. The enhanced production of Scenedesmus sp. MB 23 indicated that effective bioremediation of fish waste can be conducted using algal mass production in fish silage. The study also proved that microalgae grown in fish silage have great industrial potential and can be used as a source of feed and biofuel.

  3. Atopic dermatitis in West Highland white terriers is associated with a 1.3-Mb region on CFA 17.

    Science.gov (United States)

    Roque, Joana B; O'Leary, Caroline A; Duffy, David L; Kyaw-Tanner, Myat; Gharahkhani, Puya; Vogelnest, Linda; Mason, Kenneth; Shipstone, Michael; Latter, Melanie

    2012-03-01

    Canine atopic dermatitis (AD) is an allergic inflammatory skin disease that shares similarities with AD in humans. Canine AD is likely to be an inherited disease in dogs and is common in West Highland white terriers (WHWTs). We performed a genome-wide association study using the Affymetrix Canine SNP V2 array consisting of over 42,800 single nucleotide polymorphisms, on 35 atopic and 25 non-atopic WHWTs. A gene-dropping simulation method, using SIB-PAIR, identified a projected 1.3 Mb area of association (genome-wide P = 6 × 10(-5) to P = 7 × 10(-4)) on CFA 17. Nineteen genes on CFA 17, including 1 potential candidate gene (PTPN22), were located less than 0.5 Mb from the interval of association identified on the genome-wide association analysis. Four haplotypes within this locus were differently distributed between cases and controls in this population of dogs. These findings suggest that a major locus for canine AD in WHWTs may be located on, or in close proximity to an area on CFA 17.

  4. Experimental determination of spectral indices by scanning of fuel rod in the IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Fanaro, Leda Cristina Cabelo Bernardes

    2009-01-01

    In this work, the spectral indexes 28ρ * and 25δ * , and gamma efficiency factor in the IPEN/MB-01 reactor were determined experimentally employing a rod scanning technique. In the case of 28ρ * , this method has the advantage of eliminating most of the correction factors derived from the calculations. Only the fission yield factor and the relative fission rate in the 235 U remain in the determination of the 25δ * . The experiments were performed with different thicknesses of cadmium sleeves: 0.55 mm, 1.10 mm and 2.20 mm. The final experimental uncertainty achieved in the experiment, less that 1 %, and the excellent geometrical and material data characterization of the IPEN/MB-01 reactor allow to use the results as benchmark for validate calculation methods and related nuclear data libraries. The comparison between calculated values and experimental values was performed by employing the MCNP-5 code and the nuclear data libraries: ENDF/B-VI.8, ENDF/B-VII.0, JENDL-3.3 and JEFF-3.1. The results demonstrate that the difference among libraries is very small. Also, the comparison between calculated values and experimental values shows that there has been considerable progress in the recent nuclear data libraries. The best result is obtained with ENDF/B-VII.0 nuclear data library, and the highest discrepancy was obtained with JEFF-3.1 and JENDL-3.3 nuclear data libraries. (author)

  5. Characterization of inorganic phosphate transport in the triple-negative breast cancer cell line, MDA-MB-231.

    Science.gov (United States)

    Russo-Abrahão, Thais; Lacerda-Abreu, Marco Antônio; Gomes, Tainá; Cosentino-Gomes, Daniela; Carvalho-de-Araújo, Ayra Diandra; Rodrigues, Mariana Figueiredo; Oliveira, Ana Carolina Leal de; Rumjanek, Franklin David; Monteiro, Robson de Queiroz; Meyer-Fernandes, José Roberto

    2018-01-01

    Recent studies demonstrate that interstitial inorganic phosphate is significantly elevated in the breast cancer microenvironment as compared to normal tissue. In addition it has been shown that breast cancer cells express high levels of the NaPi-IIb carrier (SLC34A2), suggesting that this carrier may play a role in breast cancer progression. However, the biochemical behavior of inorganic phosphate (Pi) transporter in this cancer type remains elusive. In this work, we characterize the kinetic parameters of Pi transport in the aggressive human breast cancer cell line, MDA-MB-231, and correlated Pi transport with cell migration and adhesion. We determined the influence of sodium concentration, pH, metabolic inhibitors, as well as the affinity for inorganic phosphate in Pi transport. We observed that the inorganic phosphate is dependent on sodium transport (K0,5 value = 21.98 mM for NaCl). Furthermore, the transport is modulated by different pH values and increasing concentrations of Pi, following the Michaelis-Menten kinetics (K0,5 = 0.08 mM Pi). PFA, monensin, furosemide and ouabain inhibited Pi transport, cell migration and adhesion. Taken together, these results showed that the uptake of Pi in MDA-MB-231 cells is modulated by sodium and by regulatory mechanisms of intracellular sodium gradient. General Significance: Pi transport might be regarded as a potential target for therapy against tumor progression.

  6. Alteration of gene expression in MDA-MB-453 breast cancer cell line in response to continuous exposure to Trastuzumab.

    Science.gov (United States)

    Sharieh, Elham Abu; Awidi, Abdulla S; Ahram, Mamoun; Zihlif, Malek A

    2016-01-10

    Development of resistance against cancer therapeutic agents is a common problem in cancer management. Trastuzumab resistance is one of the challenges in management of HER-2-positive breast cancer patients resulting in breast cancer progression, metastasis, and patient poor outcome. The aim of this study is to determine the alteration in gene expression in response to Trastuzumab resistance after long-term exposure to Trastuzumab. The Trastuzumab-resistant MDA-MB-453 (MDA-MB-453/TR) cell line was developed by exposing cells to 10 μM Trastuzumab continuously for 6 months. Sensitivity toward Trastuzumab was tested using cell viability assays. The acquisition of an epithelial-to mesenchymal transition (EMT) phenotype was also observed in parallel with the development of resistance. Based on the real-time-based PCR array technology, several genes were altered affecting multiple networks. The most up-regulated genes were TGF-β1 and EGF, and IGFBP-3. These genes are known to have a critical role in Trastuzumab resistance in breast cancer cell lines and/or in the acquisition of EMT. They are also recognized for their role in cancer progression and metastasis. These alterations indicate that the development of Trastuzumab resistance is multifactorial and involves a development of a mesenchymal like phenotype. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells

    International Nuclear Information System (INIS)

    Rose, Peter; Huang, Qing; Ong, Choon Nam; Whiteman, Matt

    2005-01-01

    A high dietary intake of cruciferous vegetables has been associated with a reduction in numerous human pathologies particularly cancer. In the current study, we examined the inhibitory effects of broccoli (Brassica oleracea var. italica) and watercress (Rorripa nasturtium aquaticum) extracts on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cancer cell invasion and matrix metalloproteinase-9 activity using human MDA-MB-231 breast cancer cells. Aberrant overexpression of matrix metalloproteinases, including metalloproteinase-9, is associated with increased invasive potential in cancer cell lines. Our results demonstrate that extracts of broccoli and Rorripa suppressed TPA-induced MMP-9 activity and invasiveness in a concentration dependant manner as determined by zymographic analysis. Furthermore, fractionation of individual extracts followed by liquid chromatography mass spectroscopy analysis (LC-MS) revealed that the inhibitory effects of each vegetable were associated with the presence of 4-methysulfinylbutyl (sulforaphane) and 7-methylsulphinylheptyl isothiocyanates. Taken together, our data indicate that isothiocyanates derived form broccoli and Rorripa inhibit metalloproteinase 9 activities and also suppress the invasive potential of human MDA-MB-231 breast cancer cells in vitro. The inhibitory effects observed in the current study may contribute to the suppression of carcinogenesis by diets high in cruciferous vegetables

  8. KIAA0100 Modulates Cancer Cell Aggression Behavior of MDA-MB-231 through Microtubule and Heat Shock Proteins

    Directory of Open Access Journals (Sweden)

    Zhenyu Zhong

    2018-06-01

    Full Text Available The KIAA0100 gene was identified in the human immature myeloid cell line cDNA library. Recent studies have shown that its expression is elevated in breast cancer and associated with more aggressive cancer types as well as poor outcomes. However, its cellular and molecular function is yet to be understood. Here we show that silencing KIAA0100 by siRNA in the breast cancer cell line MDA-MB-231 significantly reduced the cancer cells’ aggressive behavior, including cell aggregation, reattachment, cell metastasis and invasion. Most importantly, silencing the expression of KIAA0100 particularly sensitized the quiescent cancer cells in suspension culture to anoikis. Immunoprecipitation, mass spectrometry and immunofluorescence analysis revealed that KIAA0100 may play multiple roles in the cancer cells, including stabilizing microtubule structure as a microtubule binding protein, and contributing to MDA-MB-231 cells Anoikis resistance by the interaction with stress protein HSPA1A. Our study also implies that the interaction between KIAA0100 and HSPA1A may be targeted for new drug development to specifically induce anoikis cell death in the cancer cell.

  9. Comparação entre troponina I cardíaca e CK-MB massa em síndrome coronariana aguda sem supra de ST Comparación entre troponina i cardíaca y ck-mb masa en síndrome coronario agudo sin supradesnivel de ST Comparison between cardiac troponin I and CK-MB mass in acute coronary syndrome without st elevation

    Directory of Open Access Journals (Sweden)

    Elizabete Silva dos Santos

    2011-03-01

    Full Text Available FUNDAMENTO: Há incertezas do valor prognóstico comparativo entre troponina I cardíaca (cTnI e CK-MB em síndrome coronariana aguda (SCA. OBJETIVO: Comparar o valor prognóstico entre a cTnI e a CK-MB massa em pacientes com SCA sem supradesnível do segmento ST. MÉTODOS: Foram analisados 1.027 pacientes, de modo prospectivo, em um centro terciário de cardiologia. Combinações dos biomarcadores foram examinadas: cTnI normal, CK-MB massa normal (65,5%; cTnI normal, CK-MB massa elevada (3,9%; cTnI elevada, CK-MB massa normal (8,8%; cTnI elevada, CK-MB massa elevada (20,7%. Análise multivariada de variáveis clínicas, eletrocardiográficas e laboratoriais determinou o valor prognóstico independente dos biomarcadores para o evento de morte ou (reinfarto em 30 dias. RESULTADOS: Pacientes com pelo menos um biomarcador elevado foram mais idosos (p = 0,02 e do sexo masculino (p FUNDAMENTO: Hay dudas sobre el valor pronóstico comparativo entre troponina I cardíaca (cTnI y CK-MB en síndrome coronario agudo (SCA. OBJETIVO: Comparar el valor pronóstico entre la cTnI y la CK-MB masa en pacientes con SCA sin supradesnivel del segmento ST. MÉTODOS: Fueron analizados 1.027 pacientes, de modo prospectivo, en un centro terciario de cardiología. Combinaciones de los biomarcadores fueron examinadas: cTnI normal, CK-MB masa normal (65,5%; cTnI normal, CK-MB masa elevada (3,9%; cTnI elevada, CK-MB masa normal (8,8%; cTnI elevada, CK-MB masa elevada (20,7%. Análisis multivariado de variables clínicas, electrocardiográficas y de laboratorio determinó el valor pronóstico independiente de los biomarcadores para el evento de muerte o (reinfarto en 30 días. RESULTADOS: Pacientes con por lo menos un biomarcador elevado eron más añosos (p = 0,02 y del sexo masculino (p BACKGROUND: There is uncertainty as to the comparative prognostic value between cardiac troponin I (cTnI and CK-MB in acute coronary syndrome (ACS. OBJECTIVE: To compare the prognostic

  10. Electricity - a great asset for Canada

    International Nuclear Information System (INIS)

    Chretien, Jean.

    1983-06-01

    Canada has a great national asset in its ability to generate electricity economically from its abundant hydro, coal, and uranium resources. Its nuclear industry has an excellent product. Despite lack of orders for now, the CANDU will be a competitive force when the reactor market recovers. Canada has a proven record of reliability for electricity trade with the United States. There appear to be some opportunities for plants in Canada dedicated to the export of electric power. The federal government is prepared to work closely with the provinces to develop projects which will be attractive to customers in the United States

  11. Nuclear fuel waste disposal in Canada

    International Nuclear Information System (INIS)

    Dormuth, K.W.; Gillespie, P.A.

    1990-05-01

    Atomic Energy of Canada Limited (AECL) has developed a concept for disposing of Canada's nuclear fuel waste and is submitting it for review under Federal Environmental Assessment and Review Process. During this review, AECL intends to show that careful, controlled burial 500 to 1000 metres deep in plutonic rock of the Canadian Precambrian Shield is a safe and feasible way to dispose of Canada's nuclear fuel waste. The concept has been assessed without identifying or evaluating any particular site for disposal. AECL is now preparing a comprehensive report based on more than 10 years of research and development

  12. Nuclear fuel waste disposal in Canada

    International Nuclear Information System (INIS)

    Dormuth, K.W.; Gillespie, P.A.

    1990-05-01

    Atomic Energy of Canada Limited (AECL) has developed a concept for disposing of Canada's nuclear fuel waste and is submitting it for review under the Federal Environmental Assessment and Review Process. During this review, AECL intends to show that careful, controlled burial 500 to 1000 metres deep in plutonic rock of the Canadian Precambrian Shield is a safe and feasible way to dispose of Canada's nuclear fuel waste. The concept has been assessed without identifying or evaluating any particular site for disposal. AECL is now preparing a comprehensive report based on more than 10 years of research and development

  13. Operational expert system applications in Canada

    CERN Document Server

    Suen, Ching Y

    1992-01-01

    This book is part of a new series on operational expert systems worldwide. Expert systems are now widely used in different parts of the world for various applications. The past four years have witnessed a steady growth in the development and deployment of expert systems in Canada. Research in this field has also gained considerable momentum during the past few years. However, the field of expert systems is still young in Canada. This book contains 13 chapters contributed by 31 experts from both universities and industries across Canada covering a wide range of applications related to electric

  14. Rural women caregivers in Canada.

    Science.gov (United States)

    Crosato, Kay E; Leipert, Beverly

    2006-01-01

    Informal caregiving within rural contexts in Canada is increasing. This is due in part to a number of factors related to the restructuring of the Canadian health care system, the regionalization of services to urban locations, the increased population of people 65 years and older, and the desire of this population to age within their rural homes. Most often, the informal caregiving role is assumed by rural women. Women tend to fall into the role of informal caregiver to elders because of the many societal and gender expectations and values that are present within the rural culture. The purpose of this literature review is to identify the context in which women provide care for an elder in rural Canada. Illustrating these issues will help to uncover challenges and barriers rural women face when providing care and highlight recommendations and implications for rural women caregivers and nurses employed within rural settings. Many rural women share similar caregiving experiences as urban informal caregivers, but rural women are faced with additional challenges in providing quality care for an elder. Rural women caregivers are faced with such issues as limited access to adequate and appropriate healthcare services, culturally incongruent health care, geographical distance from regionalized centers and health services, transportation challenges, and social/geographical isolation. In addition to these issues, many rural women are faced with the multiple role demands that attend being a wife, mother, caregiver and employee. The pile up of these factors leaves rural women caregivers susceptible to additional stresses and burn out, with limited resources on which to depend. Through reviewing pertinent literature, appropriate implications and recommendations can be made that may assist rural women caregivers and rural nurses. Nurses working within rural communities are in ideal settings to work collaboratively in building supportive relationships with rural women in order to

  15. Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: Role of β-catenin/connexin43 association

    International Nuclear Information System (INIS)

    Talhouk, Rabih S.; Fares, Mohamed-Bilal; Rahme, Gilbert J.; Hariri, Hanaa H.; Rayess, Tina; Dbouk, Hashem A.; Bazzoun, Dana; Al-Labban, Dania; El-Sabban, Marwan E.

    2013-01-01

    Connexins (Cx), gap junction (GJ) proteins, are regarded as tumor suppressors, and Cx43 expression is often down regulated in breast tumors. We assessed the effect of Cx43 over-expression in 2D and 3D cultures of two breast adenocarcinoma cell lines: MCF-7 and MDA-MB-231. While Cx43 over-expression decreased proliferation of 2D and 3D cultures of MCF-7 by 56% and 80% respectively, MDA-MB-231 growth was not altered in 2D cultures, but exhibited 35% reduction in 3D cultures. C-terminus truncated Cx43 did not alter proliferation. Untransfected MCF-7 cells formed spherical aggregates in 3D cultures, and MDA-MB-231 cells formed stellar aggregates. However, MCF-7 cells over-expressing Cx43 formed smaller sized clusters and Cx43 expressing MDA-MB-231 cells lost their stellar morphology. Extravasation ability of both MCF-7 and MDA-MB-231 cells was reduced by 60% and 30% respectively. On the other hand, silencing Cx43 in MCF10A cells, nonneoplastic human mammary cell line, increased proliferation in both 2D and 3D cultures, and disrupted acinar morphology. Although Cx43 over-expression did not affect total levels of β-catenin, α-catenin and ZO-2, it decreased nuclear levels of β-catenin in 2D and 3D cultures of MCF-7 cells, and in 3D cultures of MDA-MB-231 cells. Cx43 associated at the membrane with α-catenin, β-catenin and ZO-2 in 2D and 3D cultures of MCF-7 cells, and only in 3D conditions in MDA-MB-231 cells. This study suggests that Cx43 exerts tumor suppressive effects in a context-dependent manner where GJ assembly with α-catenin, β-catenin and ZO-2 may be implicated in reducing growth rate, invasiveness, and, malignant phenotype of 2D and 3D cultures of MCF-7 cells, and 3D cultures of MDA-MB-231 cells, by sequestering β-catenin away from nucleus. - Highlights: • Cx43 over-expressing MCF-7 and MDA-MB-231 were grown in 2D and 3D cultures. • Proliferation and growth morphology were affected in a context dependent manner. • Extravasation ability of both MCF

  16. Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: Role of β-catenin/connexin43 association

    Energy Technology Data Exchange (ETDEWEB)

    Talhouk, Rabih S., E-mail: rtalhouk@aub.edu.lb [Department of Biology, Faculty of Arts and Sciences, American University of Beirut, P.O. Box 11-0236, Beirut (Lebanon); Fares, Mohamed-Bilal; Rahme, Gilbert J.; Hariri, Hanaa H.; Rayess, Tina; Dbouk, Hashem A.; Bazzoun, Dana; Al-Labban, Dania [Department of Biology, Faculty of Arts and Sciences, American University of Beirut, P.O. Box 11-0236, Beirut (Lebanon); El-Sabban, Marwan E., E-mail: me00@aub.edu.lb [Department of Anatomy, Cell Biology and Physiology, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Beirut (Lebanon)

    2013-12-10

    Connexins (Cx), gap junction (GJ) proteins, are regarded as tumor suppressors, and Cx43 expression is often down regulated in breast tumors. We assessed the effect of Cx43 over-expression in 2D and 3D cultures of two breast adenocarcinoma cell lines: MCF-7 and MDA-MB-231. While Cx43 over-expression decreased proliferation of 2D and 3D cultures of MCF-7 by 56% and 80% respectively, MDA-MB-231 growth was not altered in 2D cultures, but exhibited 35% reduction in 3D cultures. C-terminus truncated Cx43 did not alter proliferation. Untransfected MCF-7 cells formed spherical aggregates in 3D cultures, and MDA-MB-231 cells formed stellar aggregates. However, MCF-7 cells over-expressing Cx43 formed smaller sized clusters and Cx43 expressing MDA-MB-231 cells lost their stellar morphology. Extravasation ability of both MCF-7 and MDA-MB-231 cells was reduced by 60% and 30% respectively. On the other hand, silencing Cx43 in MCF10A cells, nonneoplastic human mammary cell line, increased proliferation in both 2D and 3D cultures, and disrupted acinar morphology. Although Cx43 over-expression did not affect total levels of β-catenin, α-catenin and ZO-2, it decreased nuclear levels of β-catenin in 2D and 3D cultures of MCF-7 cells, and in 3D cultures of MDA-MB-231 cells. Cx43 associated at the membrane with α-catenin, β-catenin and ZO-2 in 2D and 3D cultures of MCF-7 cells, and only in 3D conditions in MDA-MB-231 cells. This study suggests that Cx43 exerts tumor suppressive effects in a context-dependent manner where GJ assembly with α-catenin, β-catenin and ZO-2 may be implicated in reducing growth rate, invasiveness, and, malignant phenotype of 2D and 3D cultures of MCF-7 cells, and 3D cultures of MDA-MB-231 cells, by sequestering β-catenin away from nucleus. - Highlights: • Cx43 over-expressing MCF-7 and MDA-MB-231 were grown in 2D and 3D cultures. • Proliferation and growth morphology were affected in a context dependent manner. • Extravasation ability of both MCF

  17. Western Canada drilling cycle optimization

    International Nuclear Information System (INIS)

    2003-06-01

    The oil and gas industry in western Canada operates in annual and seasonal cycles with peak activity periods that require a large skilled labour force for short periods of time. This study examines why seismic and drilling activity is greatest during the first quarter of the year instead of being distributed evenly over the year. The objective of the study was to provide recommendations that would help optimize the industry cycle. The study includes an analysis of historical trends that validate the industry first quarter peaking activity. It also includes interviews with 36 industry representatives and provides insight and validation of trends. The final phase of the report includes recommendations that both industry and governments may wish to implement. The study includes financial, operational and environmental considerations. It was shown that natural gas directed drilling activity is strongly correlated with changes in natural gas prices. In the case of oil drilling activity, peak activity responds to oil prices from the prior quarter. In general, drilling and seismic costs are higher in the winter months because of increased demand for equipment and services. In addition winter drilling operations require a diesel fired boiler to generate steam. 36 refs., 2 tabs., 52 figs

  18. Understanding gasoline pricing in Canada

    International Nuclear Information System (INIS)

    2001-04-01

    This brochure is designed to help consumers understand how gasoline is priced and explained why prices increase, fluctuate and vary by location, city or region. The price of a litre of gasoline reflects the costs of crude oil, refining, retailing and taxes. Taxes are usually the largest single component of gasoline prices, averaging 40 to 50 per cent of the pump price. The cost of crude oil makes up another 35 to 45 per cent of the price. Refining costs make up 10 to 15 per cent while the remaining 5 to 10 per cent represents retail costs. Gasoline retailers make a profit of about 1 cent per litre. The latest network technology allows national and regional retail chains to constantly monitor price fluctuations to change their prices at gasoline stations at a moments notice to keep up with the competition and to protect their market shares. Several government studies, plus the Conference Board of Canada, have reported that competition is working in favour of Canadian motorists. This brochure also explained the drawbacks of regulating crude and pump prices with the reminder that crude prices were regulated in the 1970s with many negative consequences. 2 tabs., 1 fig

  19. Situation awareness system for Canada

    Science.gov (United States)

    Hill, Andrew

    1999-07-01

    Situation awareness encompasses a knowledge of orders, plans and current knowledge of friendly force actions. Knowing where you are and being able to transmit that information in near real-time to other friendly forces provides the ability to exercise precise command and control over those forces. With respect to current command and control using voice methods, between 40 percent and 60 percent of Combat Net Radio traffic relates to location reporting of some sort. Commanders at Battle Group and below spend, on average, 40 percent of their total time performing position and navigation related functions. The need to rapidly transfer own force location information throughout a force and to process the received information quickly, accurately and reliably provides the rationale for the requirement for an automated situation awareness system. This paper describes the Situation Awareness System (SAS) being developed by Computing Devices Canada for the Canadian Department of National Defence as a component of the Position Determination and Navigation for Land Forces program. The SAS is being integrated with the Iris Tactical Command, Control, Communications System, which is also being developed by Computing Devices. The SAS software provides a core operating environment onto which command and control functionality can be easily added to produce general and specialist battlefield management systems.

  20. Gulf Canada's Russian joint venture

    International Nuclear Information System (INIS)

    Motyka, D.

    1992-01-01

    After three years of evaluating prospects and negotiating with government and industry representatives, Gulf Canada established its first joint venture in the Russian Federation with Komineft, a production association from the Komi autonomous republic. Komineft has a 50% share of the venture, and the rest is shared equally between Gulf and British Gas. The operating area is at the Vozey and Upper Vozey fields in the Timan-Pechora Basin, some 1,500 km northeast of Moscow just inside the Arctic Circle. An attractive feature of the Upper Vozey project is low development costs of ca $2/bbl. In the Vozey field, the venture will set up an enhanced oil recovery demonstration project to test techniques perfected in Alberta. About 60 Canadians are involved on the project, and headquarters are in Usinsk, ca 100 km south of the oil fields. In the first half of 1992, oil production in the first phase of the venture averaged around 10,000 bbl/d and continues to increase

  1. Canada Research Chairs | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    aspx. International Research Chairs Initiative. The International Research Chairs Initiative pairs top research talent from universities in Canada with their counterparts in developing countries to address key development challenges. View more

  2. Building the energy infrastructure in Atlantic Canada

    Energy Technology Data Exchange (ETDEWEB)

    Curry, T. [Atlantica Centre for Energy, Saint John, New Brunswick (Canada)]. E-mail: tim.curry@atlanticaenergy.org

    2007-07-01

    This paper discusses the energy infrastructure in Atlantic Canada. The energy development is poised to help transform the economy of New Brunswick. Planning for energy projects and supporting infrastructure are under way and regional opportunities are emerging.

  3. Inventory of pediatric neurology "manpower" in Canada.

    Science.gov (United States)

    Keene, Daniel L; Humphreys, Peter

    2005-08-01

    To review the demographics and workload characteristics of pediatric neurology in Canada. A standardized survey questionnaire was mailed out to practicing pediatric neurologists in Canada in 2001. Variables examined were age, gender, hours on call, regular hours worked per week, type of practice and projected changes in practice over next five to ten years. Results were compared to the 1994 Pediatric Neurology Manpower Survey which had used the same survey instrument. Fifty-six (70%) pediatric neurologists practicing in Canada returned the survey. As was the case in 1994, no significant differences in workload were found based on age or gender. The average age of the practicing pediatric neurologist in 2001 was 51 years compared to 45 years in 1994. The proportion of physicians over 55 years in 2001 was 35% compared to 25% in 1994. Pediatric neurology in Canada is an aging specialty needing a significant recruitment of new members

  4. Emerging Churches in Post-Christian Canada

    Directory of Open Access Journals (Sweden)

    Steven Studebaker

    2012-09-01

    Full Text Available The traditional mainline and evangelical churches in Canada, as in most western countries, are either in decline or static. Taken as a measure of the future, the prospects for Christianity in Canada, and more broadly the West, are bleak. Post-Christian Canada, however, contains thriving alternative and innovative forms of church, often called ‘emerging’ churches. They take many forms of expression, but share common theological convictions. Based on site research and personal interviews, this article describes the various types and contexts of these churches in Canada. It then highlights three of their central theological characteristics. First, rejecting the ‘culture wars’ social involvement of Christendom churches, they embrace practices and initiatives that transform their local communities. Second, they embrace an incarnational and contextual understanding of Christian life and ministry. Eschewing mega-church franchise models, they endeavor to shape their ministry to the their local communities. Third, they adopt a comprehensive rather than compartmental spirituality.

  5. Building the energy infrastructure in Atlantic Canada

    International Nuclear Information System (INIS)

    Curry, T.

    2007-01-01

    This paper discusses the energy infrastructure in Atlantic Canada. The energy development is poised to help transform the economy of New Brunswick. Planning for energy projects and supporting infrastructure are under way and regional opportunities are emerging

  6. Canada's nuclear non-proliferation policy

    International Nuclear Information System (INIS)

    1982-05-01

    Canada's non-proliferation safeguards policy has two objectives: 1) to promote a more effective and comprehensive international non-proliferation regime; and 2) to ensure that Canadian nuclear exports will not be used for any nuclear explosive purpose. By emphasizing the key role of the Non-Proliferation Treaty, promoting reliance upon and improvements in the IAEA safeguards system, treating nuclear weapon and non-weapon states alike, and working for new approaches covering reprocessing, Canada promotes attainment of the first objective. The second is served through the network of bilateral nuclear agreements that Canada has put into place with its partners. The Canadian objective in post-INFCE forums is to persuade the international community to devise a more effective and comprehensive non-proliferation regime into which Canada and other suppliers may subsume their national requirements

  7. Raw materials for energy generation in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, D S

    1976-03-01

    Canada is self-sufficient in energy. The energy demand in Canada up to the end of the century is predicted, and the present and future of the oil, gas, coal and uranium industries are considered. Since it is now Canadian policy to restrict export of energy sources, in the future Canada will probably make more domestic use of its coal reserves. An increase is forecast in the use of coal for electricity generation and as a feedstock for synthetic gas. A long lead time and large capital expenditure will be needed before coal can be transported from western Canada to markets in the east of the country. A relatively small amount of the coal reserves are extractable by surface mining, and new underground mining techniques will be needed to extract the extremely friable coal from the deformed seams in the mountains.

  8. Opportunities for manufactured housing in Canada

    National Research Council Canada - National Science Library

    Bairstow, Dale

    1985-01-01

    In the fall of 1984, Canada Mortgage and Housing Corporation commissioned this study because it wanted to find out why manufactured housing appeared to be increasing in importance in certain foreign...

  9. Global Entrepreneurship Monitor - Canada Survey | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Researchers will follow the Global Entrepreneurship Monitor (GEM) program ... The study will provide detailed information on entrepreneurship in Canada that is ... sector, public sector, and civil society organizations on development issues.

  10. Gulf Canada Resources Limited 1998 annual report

    International Nuclear Information System (INIS)

    1999-01-01

    A review of operations in 1998 and financial information from Gulf Canada Resources Limited is provided to keep shareholders abreast of company performance. Gulf Canada Resources Limited explores for, develops, produces and markets conventional and synthetic crude oil, natural gas and natural gas liquids. In 1998, the company's main operating centres were in western Canada (where it owns a nine per cent interest in the Syncrude Joint Venture), Indonesia, the North Sea and Australia. The report summarizes the company's energy resource activities, presents a detailed review of operations, and provides consolidated financial statements, and common share information. Although Gulf Canada Resources sold $ 1.2 billion worth of non-producing assets during the year, year end proved reserves of 838 million barrels of oil equivalent were less than ten per cent lower than a year earlier, reflecting reserve additions of 100 million barrels of oil equivalent. tabs., figs

  11. Canada files WTO complaint against EC.

    Science.gov (United States)

    2000-01-01

    In December 1998, Canada filed a complaint alleging that the European Communities (EC) had adopted regulations that amounted to a scheme to extend patent terms, limited to pharmaceutical and agricultural chemical products.

  12. Canada Education Savings Program: Annual Statistical Review--2009

    Science.gov (United States)

    Human Resources and Skills Development Canada, 2009

    2009-01-01

    The Canada Education Savings Program is an initiative of the Government of Canada. As part of the Department of Human Resources and Skills Development, the program administers the Canada Education Savings Grant and the Canada Learning Bond. These two initiatives help Canadian families save for a child's post-secondary education in Registered…

  13. Canada Education Savings Program: Annual Statistical Review 2011

    Science.gov (United States)

    Human Resources and Skills Development Canada, 2011

    2011-01-01

    The Canada Education Savings Program has been an initiative of the Government of Canada since 1998. As part of the Department of Human Resources and Skills Development, the program administers the Canada Education Savings Grant and the Canada Learning Bond. These two initiatives help Canadian families save for a child's post-secondary education in…

  14. 9 CFR 93.317 - Horses from Canada.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Horses from Canada. 93.317 Section 93... CONVEYANCE AND SHIPPING CONTAINERS Horses Canada 16 § 93.317 Horses from Canada. (a) Except as provided in paragraph (c) of this section, horses from Canada shall be inspected as provided in § 93.306; shall be...

  15. 19 CFR 123.41 - Truck shipments transiting Canada.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Truck shipments transiting Canada. 123.41 Section... OF THE TREASURY CUSTOMS RELATIONS WITH CANADA AND MEXICO United States and Canada In-Transit Truck Procedures § 123.41 Truck shipments transiting Canada. (a) Manifest required. Trucks with merchandise...

  16. 9 CFR 93.418 - Cattle from Canada.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Cattle from Canada. 93.418 Section 93... CONVEYANCE AND SHIPPING CONTAINERS Ruminants Canada 8 § 93.418 Cattle from Canada. (a) Health certificates. Cattle intended for importation from Canada must be accompanied by a certificate issued in accordance...

  17. 9 CFR 93.517 - Swine from Canada.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Swine from Canada. 93.517 Section 93... CONVEYANCE AND SHIPPING CONTAINERS Swine Canada 7 § 93.517 Swine from Canada. (a) For purposes other than immediate slaughter. Swine offered for importation from Canada for purposes other than immediate slaughter...

  18. The non Opec petroleum supply would get from 42 to 47 Mb/day from 1995 until 2000 but the call to Opec petroleum would reach 50 Mb/day in the year 2010

    International Nuclear Information System (INIS)

    Anon.

    1996-01-01

    The increase of non Opec petroleum supply is going to reach 47 Mb/d in 2000. This increase comes from the North sea production and that is the reason why the international Energy Agency estimates that the petroleum prices, except supply disruption, will not increase. An increase of international energy demand is predicted from 34% to 46% between 1995 and 2010. This demand will be satisfied by fossil fuels. The petroleum demand will become from 70 millions of barrels by day to 92 and 97 millions barrels by day in 2010. The dependence of OECD countries could reach 60% in 2010 against 50% nowadays. It is predicted that middle east Opec countries would supply 50% of the worldwide petroleum needs and the OECD energy consumption could represent 50% of the worldwide energy consumption. (N.C.). 3 tabs

  19. The reflector effect on the neutron lifetimes in the IPEN/MB-01 reactor; O efeito do refletor sobre o tempo de vida neutronico no reator IPEN/MB-01

    Energy Technology Data Exchange (ETDEWEB)

    Gonnelli, Eduardo

    2013-07-01

    The aim of this study is to present the reflector effect on the neutron lifetimes in the IPEN/MB-01 reactor. The proposed method requires an approach which takes into account both the reflector and the core, so that the point kinetics equations, which constitute the theoretical basis of all mathematical development, contemplate both regions of the reactor. From these equations, as known as two regions kinetics point equations, theoretical expressions are obtained for the Auto Power Spectral Densities (APSD), which are used for least squares fit of the experimental data of APSD obtained in several subcritical states. The prompt neutron generation time, the neutron lifetimes in the reflector and the neutron return fraction from the reflector to the core are derived from the fitting. (author)

  20. NDT in Canada - the next 20 years

    International Nuclear Information System (INIS)

    Kittmer, C.A.

    1985-01-01

    The theme for the Fifth Canadian Conference on Nondestructive Testing was 'NDT in Canada - The Next 20 years'. The three day conference with 42 presentations provided a short overview of NDT in Canada, a look at NDT in pipeline, materials, offshore, nuclear and training applications, and a glimpse into the next 20 years with recent advances in research and development as related to this 'hi-tech' field of work

  1. Determination of buckling and probability of leakage of neutron in the IPEN/MB-01 reactor in cylindrical configuration; Medida do buckling e da probabilidade de fuga de neutrons do nucleo do reator IPEN/MB-01

    Energy Technology Data Exchange (ETDEWEB)

    Purgato, Rafael Turrini

    2014-07-01

    One of the key parameters in reactor physics is the Buckling of a reactor core. It is related to important parameters such as reaction rates, nuclear power operation, fuel burning, among others. In a critical reactor, the Buckling depends on the geometric and material characteristics of the reactor core. This work presents the results of experimental Buckling in the reactor IPEN/MB-01 nuclear reactor in its cylindrical configuration with 28 fuel rods along its diameter. The IPEN/MB-01 is a zero power reactor designed to operate at a maximum power of 100 watts, it is a versatile nuclear facility which allows the simulation of all the characteristics of a large nuclear power reactor and ideal for this type of measurement. We conducted a mapping of neutron flux inside the reactor and thereby determined the total Buckling of the cylindrical configuration. The reactor was operated for one hour. Then, the activity of the fuel rods was measured by gamma spectrometry on a rod scanner HPGe detector. We analyzed the gamma photons of the {sup 239}Np (276,6 keV) for neutron capture (n,γ) and the {sup 143}Ce (293,3 keV) for fission (n,f) on both {sup 238}U and {sup 235}U, respectively. We analyzed the axial and radial directions. Other measurements were performed using wires and gold foils in the radial and axial directions of the reactor core. The Buckling Total obtained from the three methods by weighted mean is 96,55 ± 7,47 m{sup -2}. The goal is to obtain experimental values of a set of experimental data to allow one direct comparison with values calculated by the codes used in reactor physics CITATION and MCNP. (author)

  2. Selective regain of egfr gene copies in CD44+/CD24-/low breast cancer cellular model MDA-MB-468

    International Nuclear Information System (INIS)

    Agelopoulos, Konstantin; Buerger, Horst; Brandt, Burkhard; Greve, Burkhard; Schmidt, Hartmut; Pospisil, Heike; Kurtz, Stefan; Bartkowiak, Kai; Andreas, Antje; Wieczorek, Marek; Korsching, Eberhard

    2010-01-01

    Increased transcription of oncogenes like the epidermal growth factor receptor (EGFR) is frequently caused by amplification of the whole gene or at least of regulatory sequences. Aim of this study was to pinpoint mechanistic parameters occurring during egfr copy number gains leading to a stable EGFR overexpression and high sensitivity to extracellular signalling. A deeper understanding of those marker events might improve early diagnosis of cancer in suspect lesions, early detection of cancer progression and the prediction of egfr targeted therapies. The basal-like/stemness type breast cancer cell line subpopulation MDA-MB-468 CD44 high /CD24 -/low , carrying high egfr amplifications, was chosen as a model system in this study. Subclones of the heterogeneous cell line expressing low and high EGF receptor densities were isolated by cell sorting. Genomic profiling was carried out for these by means of SNP array profiling, qPCR and FISH. Cell cycle analysis was performed using the BrdU quenching technique. Low and high EGFR expressing MDA-MB-468 CD44 + /CD24 -/low subpopulations separated by cell sorting showed intermediate and high copy numbers of egfr, respectively. However, during cell culture an increase solely for egfr gene copy numbers in the intermediate subpopulation occurred. This shift was based on the formation of new cells which regained egfr gene copies. By two parametric cell cycle analysis clonal effects mediated through growth advantage of cells bearing higher egfr gene copy numbers could most likely be excluded for being the driving force. Subsequently, the detection of a fragile site distal to the egfr gene, sustaining uncapped telomere-less chromosomal ends, the ladder-like structure of the intrachromosomal egfr amplification and a broader range of egfr copy numbers support the assumption that dynamic chromosomal rearrangements, like breakage-fusion-bridge-cycles other than proliferation drive the gain of egfr copies. Progressive genome modulation

  3. Croatian Language Maintenance in Canada

    Directory of Open Access Journals (Sweden)

    Ivana Petrović

    2017-01-01

    Full Text Available Although the topic of language maintenance has received considerable attention from linguists around the world, there are still many aspects of this language-contact phenomenon that could be examined further. This paper aims to contribute to the existing body of knowledge by exploring the state of Croatian as a heritage language in Canada. The aim of the paper is two-fold. The first is to describe the demographic characteristics of the Croatian community by investigating the number of people of Croatian descent and the number of Croatian speakers in Canada. The second, and more specific, aim of the paper is to provide an account of the state of Croatian as a minority language and examine the extent of language maintenance in the community. To accomplish the first objective, Canadian census data (1996, 2001, 2006, and 2011 was analyzed, with special focus on linguistic census data (number and age of Croatian speakers in Canada, mother tongue of people of Croatian descent, language most used at home, etc.. To accomplish the second objective, census data was supplemented with data from a questionnaire-based survey completed by members of the Croatian community in Toronto. The survey was completed by 220 participants; 110 first-generation Croatian Canadians and 110 second-generation Croatian Canadians. Two versions of the questionnaire were designed, one for first-generation participants and the other for second-generation participants. The great majority of items in the two versions were identical; each version contained questions about demographic characteristics, language use in everyday life, and self-perceived language proficiency in English and Croatian. The majority of questions were of a closed type (multiple-choice questions and rating scales, but there were also some open-ended questions, so as to give participants the opportunity to express their viewpoint or comment on certain issues. Questions were written in both Croatian and English

  4. Reimagining Haj Khalil v. Canada

    Directory of Open Access Journals (Sweden)

    Reem Bahdi

    2009-02-01

    Full Text Available This paper emphasizes the importance of cultural competence for tort law by analyzing the Federal Court’s decision in Haj Khalil v. Canada. Given that this symposium in honour of Rose Voyvodic’s life and work is entitled “Re-Imagining Access to Justice,” this paper asks “how do the principles of cultural competence allow us to think about the facts of the Haj Khalil differently. In particular, what would a cause in fact analysis look like if it were informed by the principles of cultural competence?” My analysis proceeds by “reading the silences” or focusing on the unstated assumptions and unexplored elements of Haj Khalil’s story to bring into focus factors relevant to factual causation which remain largely unexplored or undervalued by the Federal Court. An examination of the facts that framed Haj Khalil`s claim against immigration officials through a culturally competent lens would open the possibility of a different understanding of causation as it arises on the facts of the case. While Canadian courts have emphasized the importance of social context for fair judgment, they have not fully come to grips with the implications of social context for judicial decision-making. This is particularly the case within negligence law which remains vexed by the need to maintain an objective standard while simultaneously recognizing the importance of context and circumstance to particular claims. Cet article souligne l’importance de la compétence culturelle pour le droit de la responsabilité civile délictuelle en analysant le jugement Haj Khalil c. Canada de la Cour Fédérale. Vu que ce symposium en honneur de la vie et de l’oeuvre de Rose Voyvodic est intitulé « Re-Imagining Access to Justice», cet article pose la question «comment les principes de compétence culturelle nous permettent-ils de concevoir différemment les faits de Haj Khalil. En particulier, comment se présenterait la causalité si l’analyse des faits

  5. A Strategic Analysis of Canada Post's Parcel Ecommerce Growth Strategy

    OpenAIRE

    Brock, Kerry

    2012-01-01

    Canada Post is a market leader in the business to consumer residential delivery of parcels in Canada. There is an increasing demand for residential delivery due to the worldwide growth in ecommerce sales. This paper presents a strategic analysis of the opportunity for Canada Post to increase its breadth and depth in the parcel delivery industry in Canada. The analysis will review the parcel industry, the ecommerce opportunity, an internal review of Canada Post, develop and evaluate four strat...

  6. Achievement in research on ion beam application under the scientific cooperation program with the Gesellschaft fuer schwerionenforschung mbH

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Masaru; Maekawa, Yasunari (eds.) [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    2003-03-01

    The Japan Atomic Energy Research Institute (JAERI) and the Gasellshaft fuer Schwerionenforshung mbH (GSI) signed a memorandum of 'Research and Development in the Field of Ion Beam Application' in January, 1991 and started the cooperative research program. The cooperation has been implemented by means of joint research between JAERI and GSI, exchange of scientific and technical experts, and providing mutual exchange of research materials as well as technical information. This report summarizes the cooperative research activities under the cooperative research program in the last 12 years. The list of publications and several articles relating to this cooperative research program are attached as an appendix. All the attached articles are reprinted with permission from the publishers. (author)

  7. Performance of DS-UWB in MB-OFDM and multi-user interference over Nakagami-m fading channels

    KAUST Repository

    Mehbodniya, Abolfazl

    2011-01-18

    The mutual interference between the two ultra wideband (UWB) technologies, which use the same frequency spectrum, will be a matter of concern in the near future. In this context, we present a performance analysis of direct-sequence (DS) UWB communication in the presence of multiband orthogonal frequency division multiplexing (MB-OFDM) UWB interfering transmissions. The channel fading is modeled according to Nakagami-m distribution, and multi-user interference is taken into account. The DS-UWB system performance is evaluated in terms of bit error rate (BER). Specifically, using the characteristic function approach, an analytical expression for the average BER is derived conditioned on the channel impulse response. Numerical and simulation results are provided and compared for different coexistence scenarios. © 2011 John Wiley & Sons, Ltd.

  8. A Simple Way to Overcome the Shortage of {sup 3}He Detectors in the IPEN/MB-01 Nuclear Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Gonnelli, E.; Diniz, R.; Dos Santos, A.; Jerez, R.; Landim, H.R. [Nuclear and Energy Research Institute, Nuclear Engineering Center, Nuclear Reactor Division - IPEN/CNEN, Cidade Universitaria, Av. Lineu Prestes 2242, CEP 05508-000, Sao Paulo, SP (Brazil)

    2015-07-01

    The presented work shows the preliminary results of an experimental procedure to overcome the helium-3 detectors shortage in the IPEN/MB-01 nuclear reactor and be feasible the study of the high subcritical states with less sensitivity detectors. The main principle was employing the input logic nuclear module which was possible to execute logic operations with the neutron signals. Though these signals was possible to construct the Auto Power Spectral Densities (APSD) and obtain the Prompt Neutron Constant Decay (α). Two different kinds of thermal neutron detectors were used ({sup 3}He and BF{sub 3}). The arrangement was initially constituted by one of each type detector and, posteriorly, for a more complete data acquisition, in groups of two detectors for all subcritical configurations. The experiment was carried out using the control banks (BC-1 and BC-2) insertion to achieve all the subcritical states studied in this work. (authors)

  9. COTS low-cost 622-Mb/s free-space laser communications link for short-distance commercial applications

    Science.gov (United States)

    Morrison, Kenneth A.

    2000-05-01

    The results from a low cost 622 Mb/s, free-space laser communication link operating at 850 nm for short distance commercial applications is presented. The test results demonstrate the use of a free-space laser communications transceiver for building to building applications such as LAN, WAN and ATM operations, etc. This illustrates the potential for wide-use commercial computer network applications. The transceiver is constructed of commercial off-the-shelf materials for the development of a low-cost laser communications data link. The test system configuration utilizes standard Personal Computers with network cards and signal conversion cards for the copper to optical medical conversion. These tests precede the development of an increased data rate device operating at 2.5 Gb/s.

  10. A 3.96 GHz phase-locked loop for mode-1 MB-OFDM UWB hopping carrier generation

    Energy Technology Data Exchange (ETDEWEB)

    Zheng Yongzheng; Li Weinan; Xia Lingli; Huang Yumei; Hong Zhiliang, E-mail: yumeihuang@fudan.edu.c [State Key Laboratory of ASIC and System, Fudan University, Shanghai 201203 (China)

    2009-07-15

    A fully integrated phase-locked loop (PLL) is presented for a single quadrature output frequency of 3.96 GHz. The proposed PLL can be applied to mode-1 MB-OFDM UWB hopping carrier generation. An adaptive frequency calibration loop is incorporated into the PLL. The capacitance area in the loop filter is largely reduced through a capacitor multiplier. Implemented in a CMOS process, this PLL draws 13.0 mA current from a single 1.2 V supply while occupying 0.55 mm{sup 2} die area. Measurement results show that the PLL achieves a phase noise of-70 dBc/Hz at 10 kHz offset and -113 dBc/Hz at 1 MHz offset. The integrated RMS jitter from 1 kHz to 10 MHz is 2.2 ps. The reference spur level is less than -68 dBc.

  11. A 3.96 GHz phase-locked loop for mode-1 MB-OFDM UWB hopping carrier generation

    International Nuclear Information System (INIS)

    Zheng Yongzheng; Li Weinan; Xia Lingli; Huang Yumei; Hong Zhiliang

    2009-01-01

    A fully integrated phase-locked loop (PLL) is presented for a single quadrature output frequency of 3.96 GHz. The proposed PLL can be applied to mode-1 MB-OFDM UWB hopping carrier generation. An adaptive frequency calibration loop is incorporated into the PLL. The capacitance area in the loop filter is largely reduced through a capacitor multiplier. Implemented in a CMOS process, this PLL draws 13.0 mA current from a single 1.2 V supply while occupying 0.55 mm 2 die area. Measurement results show that the PLL achieves a phase noise of-70 dBc/Hz at 10 kHz offset and -113 dBc/Hz at 1 MHz offset. The integrated RMS jitter from 1 kHz to 10 MHz is 2.2 ps. The reference spur level is less than -68 dBc.

  12. Reactivity and neutron flux measurements in IPEN/MB-01 reactor with B4C burnable poison

    International Nuclear Information System (INIS)

    Fer, Nelson Custodio; Moreira, Joao Manoel Losada

    2000-01-01

    Burnable poison rods, made of B 4 C- Al 2 O 3 pellets with 5.01 mg/cm 3 10 B concentration, have been manufactured for a set of experiments in the IPEN/MB-01 zero-power reactor. Several core parameters which are affected by the burnable poisons rods have been measured. The principal results, for the situation in which the burnable poison rods are located near the absorber rods of a control rod, are they cause a 29% rod worth shadowing, a reduction of 39% in the local void coefficient of reactivity, a reduction of 4.8% in the isothermal temperature coefficient of reactivity, and a reduction of 9% in the thermal neutron flux in the region where the burnable poison rods are located. These experimental results will be used for the validation of burnable poison calculation methods in the CTMSP. (author)

  13. Rapid control of a chancroid outbreak: implications for Canada.

    Science.gov (United States)

    Jessamine, P G; Brunham, R C

    1990-01-01

    From June to November 1987 an outbreak of chancroid occurred in Winnipeg, the first in more than 10 years; 14 people (9 men, 5 women) were involved. Nine of the cases were confirmed through culture. A control strategy was implemented in November 1987 that included presumptive treatment of genital ulcer disease with single-dose antimicrobial therapy, intensive tracing of contacts and treatment of asymptomatic sexual contacts. The origin of the outbreak was not determined, and an epidemiologic link between all the patients could not be demonstrated. The isolates were found to contain the same plasmid; this suggested that a single clone of Haemophilus ducreyi was responsible for the outbreak. Images Fig. 2 PMID:2337844

  14. Measurement of nuclear reaction rates and spectral indices along the radius of fuel pellets from IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Mura, Luis Felipe Liambos

    2010-01-01

    This work presents the measurements of the nuclear reaction rates along the radial direction of the fuel pellet by irradiation and posterior gamma spectrometry of a thin slice of fuel pellet of UO 2 with 4,3% enrichment. From its irradiation the rate of radioactive capture and fission have been measured as a function of the radius of the pellet disk using a HPGe detector. Lead collimators has been used for this purpose. Simulating the fuel pellet in the pin fuel of the IPEN/MB-01 reactor, a thin UO 2 disk is used. This disk is inserted in the interior of a dismountable fuel rod. This fuel rod is then placed in the central position of the IPEN/MB-01 reactor core and irradiated during 1 hour under a neutron flux of around 9 x 10 8 n/cm 2 s. For gamma spectrometry 10 collimators with different diameters have been used, consequently, the nuclear reactions of radioactive capture that occurs in atoms of 238 U and fissions that occur on both 235 U and 238 U are measured in function of 10 different region (diameter of collimator) of the fuel pellet disk. Corrections in the geometric efficiency due to introduction of collimators on HPGe detection system were estimated using photon transport of MCNP-4C code. Some calculated values of nuclear reaction rate of radioactive capture and fission along of the radial direction of the fuel pellet obtained by Monte Carlo methodology, using the MCNP-4C code, are presented and compared to the experimental data showing very good agreement. Besides nuclear reaction rates, the spectral indices 28 ρ and 25 δ have been obtained at each different radius of the fuel pellet disk. (author)

  15. Characterization of the neutronic fields obtained by means of neutron traps inside the nuclear reactor core IPEN/MB-01

    International Nuclear Information System (INIS)

    Mura, Luiz Ernesto Credidio

    2011-01-01

    This paper presents the results of the neutron flux values obtained from the deployment of a Flux Trap of neutrons in the reactor core IPEN/MB-01. We analyzed several configurations of Flux Traps deployed in the reactor core IPEN/MB-01 in order to get elected to Flux Trap configuration more efficient. To characterize the neutron spectrum were irradiated in the center of the Flux Trap activation detectors of different materials (Au, Sc, In, Ti, Ni). The respective gamma spectroscopy of these elements after irradiation with and without cadmium cover, provided the experimental values of the nuclear reaction rates (saturation activity) by the target nuclei and their uncertainties used as input to the code SANDBP who calculated the energy spectrum of neutrons in the center of the 'Flux-Trap' in 50 energy groups, using the input spectra calculated at the irradiation position (center of the 'Flux Trap') by codes for Reactor Physics. The results found an increase in the thermal neutron flux in the center of the Flux Trap configuration 203 for the standard configuration (default) of about 350% without having the need to increase the reactor power. We also made comparisons between the spectra obtained by SANDBP deployed, compared to those calculated by MCNP-4C code and XSDRNPM. The spatial characterization of the thermal neutron flux is made with activation foils in the form of an infinitely dilute bulk alloy of 1% Au and 99% Al in some internal points of the configuration 203 (axially to Flux Trap a nd adjacent radial) and the results showed a significant increase in the magnitude of their values when compared to standard rectangular configuration. (author)

  16. Anti-proliferative effect of biogenic gold nanoparticles against breast cancer cell lines (MDA-MB-231 & MCF-7)

    International Nuclear Information System (INIS)

    Uma Suganya, K.S.; Govindaraju, K.; Ganesh Kumar, V.; Prabhu, D.; Arulvasu, C.; Stalin Dhas, T.; Karthick, V.; Changmai, Niranjan

    2016-01-01

    Highlights: • Biosynthesis of stable and well dispersed predominantly spherical gold nanoparticles of size around ∼12.5 nm. • Anticancer assessment of gold nanoparticles on MDA-MB-231 and MCF-7 cell lines. • AuNPs were found non toxic to normal HMEC cells. • Flow cytometry results revealed significant arrest in cell proliferation in early G0/G1 to S phase. - Abstract: Breast cancer is a major complication in women and numerous approaches are being developed to overcome this problem. In conventional treatments such as chemotherapy and radiotherapy the post side effects cause an unsuitable effect in treatment of cancer. Hence, it is essential to develop a novel strategy for the treatment of this disease. In the present investigation, a possible route for green synthesis of gold nanoparticles (AuNPs) using leaf extract of Mimosa pudica and its anticancer efficacy in the treatment of breast cancer cell lines is studied. The synthesized nanoparticles were found to be effective in killing cancer cells (MDA-MB-231 & MCF-7) which were studied using various anticancer assays (MTT assay, cell morphology determination, cell cycle analysis, comet assay, Annexin V-FITC/PI staining and DAPI staining). Cell morphological analysis showed the changes occurred in cancer cells during the treatment with AuNPs. Cell cycle analysis revealed apoptosis in G_0/G_1 to S phase. Similarly in Comet assay, there was an increase in tail length in treated cells in comparison with the control. Annexin V-FITC/PI staining assay showed prompt fluorescence in treated cells indicating the translocation of phosphatidylserine from the inner membrane. PI and DAPI staining showed the DNA damage in treated cells.

  17. The Urtica dioica extract enhances sensitivity of paclitaxel drug to MDA-MB-468 breast cancer cells.

    Science.gov (United States)

    Mohammadi, Ali; Mansoori, Behzad; Aghapour, Mahyar; Shirjang, Solmaz; Nami, Sanam; Baradaran, Behzad

    2016-10-01

    Due to the chemo resistant nature of cancer cells and adverse effects of current therapies, researchers are looking for the most efficient therapeutic approach which has the lowest side effects and the highest toxicity on cancer cells. The aim of the present study was to investigate the synergic effect of Urtica dioica extract in combination with paclitaxel on cell death and invasion of human breast cancer MDA-MB-468 cell line. To determine the cytotoxic effects of Urtica dioica extract with paclitaxel, MTT assay was performed. The scratch test was exploited to assess the effects of Urtica dioica, Paclitaxel alone and combination on migration of cancer cells. The expression levels of snail-1, ZEB1, ZEB2, twist, Cdc2, cyclin B1 and Wee1 genes were quantified using qRT-PCR and western blot performed for snail-1expression. The effects of plant extract, Paclitaxel alone and combination on different phases of cell cycle was analyzed using flow cytometry. Results of MTT assay showed that Urtica dioica significantly destroyed cancer cells. Interestingly, Concurrent use of Urtica dioica extract with paclitaxel resulted in decreased IC50 dose of paclitaxel. Moreover, findings of scratch assay exhibited the inhibitory effects of Urtica dioica, Paclitaxel alone and combination on migration of MDA-MB-468 cell line. Our findings also demonstrated that the extract substantially decreased the Snail-1 and related gene expression. Ultimately, Cell cycle arrest occurred at G2/M phase post-treatment by deregulating Cdc2 and wee1. Our results demonstrated that the dichloromethane extract of Urtica dioica inhibit cell growth and migration. Also, Urtica dioica extract substantially increased sensitivity of breast cancer cells to paclitaxel. Therefore, it can be used as a potential candidate for treatment of breast cancer with paclitaxel. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  18. Determination of buckling and probability of leakage of neutron in the IPEN/MB-01 reactor in cylindrical configuration

    International Nuclear Information System (INIS)

    Purgato, Rafael Turrini

    2014-01-01

    One of the key parameters in reactor physics is the Buckling of a reactor core. It is related to important parameters such as reaction rates, nuclear power operation, fuel burning, among others. In a critical reactor, the Buckling depends on the geometric and material characteristics of the reactor core. This work presents the results of experimental Buckling in the reactor IPEN/MB-01 nuclear reactor in its cylindrical configuration with 28 fuel rods along its diameter. The IPEN/MB-01 is a zero power reactor designed to operate at a maximum power of 100 watts, it is a versatile nuclear facility which allows the simulation of all the characteristics of a large nuclear power reactor and ideal for this type of measurement. We conducted a mapping of neutron flux inside the reactor and thereby determined the total Buckling of the cylindrical configuration. The reactor was operated for one hour. Then, the activity of the fuel rods was measured by gamma spectrometry on a rod scanner HPGe detector. We analyzed the gamma photons of the 239 Np (276,6 keV) for neutron capture (n,γ) and the 143 Ce (293,3 keV) for fission (n,f) on both 238 U and 235 U, respectively. We analyzed the axial and radial directions. Other measurements were performed using wires and gold foils in the radial and axial directions of the reactor core. The Buckling Total obtained from the three methods by weighted mean is 96,55 ± 7,47 m -2 . The goal is to obtain experimental values of a set of experimental data to allow one direct comparison with values calculated by the codes used in reactor physics CITATION and MCNP. (author)

  19. Anti-proliferative effect of biogenic gold nanoparticles against breast cancer cell lines (MDA-MB-231 & MCF-7)

    Energy Technology Data Exchange (ETDEWEB)

    Uma Suganya, K.S. [Centre for Ocean Research, Sathyabama University, Chennai 600119 (India); Govindaraju, K., E-mail: govindtu@gmail.com [Centre for Ocean Research, Sathyabama University, Chennai 600119 (India); Ganesh Kumar, V. [Centre for Ocean Research, Sathyabama University, Chennai 600119 (India); Prabhu, D.; Arulvasu, C. [Department of Zoology, University of Madras, Guindy campus, Chennai 600 025 (India); Stalin Dhas, T.; Karthick, V.; Changmai, Niranjan [Centre for Ocean Research, Sathyabama University, Chennai 600119 (India)

    2016-05-15

    Highlights: • Biosynthesis of stable and well dispersed predominantly spherical gold nanoparticles of size around ∼12.5 nm. • Anticancer assessment of gold nanoparticles on MDA-MB-231 and MCF-7 cell lines. • AuNPs were found non toxic to normal HMEC cells. • Flow cytometry results revealed significant arrest in cell proliferation in early G0/G1 to S phase. - Abstract: Breast cancer is a major complication in women and numerous approaches are being developed to overcome this problem. In conventional treatments such as chemotherapy and radiotherapy the post side effects cause an unsuitable effect in treatment of cancer. Hence, it is essential to develop a novel strategy for the treatment of this disease. In the present investigation, a possible route for green synthesis of gold nanoparticles (AuNPs) using leaf extract of Mimosa pudica and its anticancer efficacy in the treatment of breast cancer cell lines is studied. The synthesized nanoparticles were found to be effective in killing cancer cells (MDA-MB-231 & MCF-7) which were studied using various anticancer assays (MTT assay, cell morphology determination, cell cycle analysis, comet assay, Annexin V-FITC/PI staining and DAPI staining). Cell morphological analysis showed the changes occurred in cancer cells during the treatment with AuNPs. Cell cycle analysis revealed apoptosis in G{sub 0}/G{sub 1} to S phase. Similarly in Comet assay, there was an increase in tail length in treated cells in comparison with the control. Annexin V-FITC/PI staining assay showed prompt fluorescence in treated cells indicating the translocation of phosphatidylserine from the inner membrane. PI and DAPI staining showed the DNA damage in treated cells.

  20. Non-Muscle Myosin II Isoforms Have Different Functions in Matrix Rearrangement by MDA-MB-231 Cells.

    Directory of Open Access Journals (Sweden)

    Bridget Hindman

    Full Text Available The role of a stiffening extra-cellular matrix (ECM in cancer progression is documented but poorly understood. Here we use a conditioning protocol to test the role of nonmuscle myosin II isoforms in cell mediated ECM arrangement using collagen constructs seeded with breast cancer cells expressing shRNA targeted to either the IIA or IIB heavy chain isoform. While there are several methods available to measure changes in the biophysical characteristics of the ECM, we wanted to use a method which allows for the measurement of global stiffness changes as well as a dynamic response from the sample over time. The conditioning protocol used allows the direct measurement of ECM stiffness. Using various treatments, it is possible to determine the contribution of various construct and cellular components to the overall construct stiffness. Using this assay, we show that both the IIA and IIB isoforms are necessary for efficient matrix remodeling by MDA-MB-231 breast cancer cells, as loss of either isoform changes the stiffness of the collagen constructs as measured using our conditioning protocol. Constructs containing only collagen had an elastic modulus of 0.40 Pascals (Pa, parental MDA-MB-231 constructs had an elastic modulus of 9.22 Pa, while IIA and IIB KD constructs had moduli of 3.42 and 7.20 Pa, respectively. We also calculated the cell and matrix contributions to the overall sample elastic modulus. Loss of either myosin isoform resulted in decreased cell stiffness, as well as a decrease in the stiffness of the cell-altered collagen matrices. While the total construct modulus for the IIB KD cells was lower than that of the parental cells, the IIB KD cell-altered matrices actually had a higher elastic modulus than the parental cell-altered matrices (4.73 versus 4.38 Pa. These results indicate that the IIA and IIB heavy chains play distinct and non-redundant roles in matrix remodeling.

  1. BETULINIC ACID WAS MORE CYTOTOXIC TOWARDS THE HUMAN BREAST CANCER CELL LINE MDA-MB-231 THAN THE HUMAN PROMYELOCYTIC LEUKAEMIA CELL LINE HL-60

    Directory of Open Access Journals (Sweden)

    LATIFAH SAIFUL YAZAN

    2009-01-01

    Full Text Available Betulinic acid (BA is a pentacyclic triterpene found in several botanical sources that has been shown to cause apoptosis in a number of cell lines. This study was undertaken to determine the in vitro cytotoxic properties of BA towards the human mammary carcinoma cell line MDA-MB-231 and the human promyelocytic leukaemia cell line HL-60 and the mode of the induced cell death. The cytotoxicity and mode of cell death of BA were determined using the MTT assay and DNAfragmentation analysis, respectively. In our study, the compound was found to be cytotoxic to MDA-MB-231 and HL-60 cells with IC50 values of 58 μg/mL and 134 μg/mL, respectively. Cells treated with high concentrations of BA exhibited features characteristic of apoptosis such as blebbing, shrinking and a number of small cytoplasm body masses when viewed under an inverted light microscope after 24 h. The incidence of apoptosis in MDA-MB-231 was further confirmed bythe DNA fragmentation analysis, with the formation of DNA fragments of oligonucleosomal size (180-200 base pairs, giving a ladder-like pattern on agarose gel electrophoresis. BA was more cytotoxic towards MDA-MB-231 than HL-60 cells, and induced apoptosis in MDA-MB-231 cells.

  2. [Inhibitory effect of exogenous insulin-like growth factor binding protein 7 on proliferation of human breast cancer cell line MDA-MB-453 and its mechanism].

    Science.gov (United States)

    Yuan, Lei; Fan, Wen-Juan; Yang, Xu-Guang; Rao, Shu-Mei; Song, Jin-Ling; Song, Guo-Hua

    2013-10-25

    The present study was to investigate the effects of exogenous insulin-like growth factor binding protein 7 (IGFBP7) on the proliferation of human breast cancer cell line MDA-MB-453 and its possible mechanism. By means of MTT method in vitro, the results showed exogenous IGFBP7 inhibited the growth of MDA-MB-453 cells (IC50 of IGFBP7 = 8.49 μg/mL) in time- and concentration-dependent manner. SB203580, p38(MAPK) inhibitor, blocked the anti-proliferative effect of exogenous IGFBP7. The flow cytometry assay showed that exogenous IGFBP7 remarkably induced G0/G1 arrest in MDA-MB-453 cells. The Western blot showed that exogenous IGFBP7 promoted phosphorylation of p38(MAPK), up-regulated expression of p21(CIP1/WAF1), and inhibited phosphorylation of Rb. SB203580 restrained exogenous IGFBP7-induced regulation of p21(CIP1/WAF1) and p-Rb in MDA-MB-453 cells. In conclusion, the present study suggests that exogenous IGFBP7 could activate the p38(MAPK) signaling pathway, upregulate p21(CIP1/WAF1) expression, inhibit phosphorylation of Rb, and finally induce G0/G1 arrest in MDA-MB-453 cells.

  3. Labelling of living mammalian spermatozoa with the fluorescent thiol alkylating agent, monobromobimane (MB): immobilization upon exposure to ultraviolet light and analysis of acrosomal status

    International Nuclear Information System (INIS)

    Cummins, J.M.; Fleming, A.D.; Crozet, N.; Kuehl, T.J.; Kosower, N.S.; Yanagimachi, R.

    1986-01-01

    Living spermatozoa of seven mammalian species were treated with the thiol-alkylating fluorescent labelling compound, monobromobimane (MBBR). MB-labelling alone had no effect on sperm motility, nor on the time course or ability of golden hamster spermatozoa to undergo the acrosome reaction when capacitated in vitro. Exposure of MB-labelled spermatozoa to ultraviolet (UV) light and excitation of the MB fluorochrome resulted in virtually immediate immobilization of the spermatozoa without affecting acrosomal status. UV exposure of unlabelled spermatozoa for up to 30 sec had no effect upon motility. Immobilization of MB-labelled spermatozoa depended on the midpiece being irradiated, as irradiation of the head alone, or of the more distal parts of the principal piece, had little or no effect upon motility. Labelling with MB followed by immobilization of individually selected spermatozoa was most useful for detailing the course and site of occurrence of the acrosome reaction during penetration of the cumulus oophorus by golden hamster spermatozoa in vitro. In these often hyperactivated spermatozoa, precise determination of the acrosomal status could not often otherwise be made due to the difficulty in visualizing the acrosomal region of a vigorously thrashing, hyperactivated spermatozoon. This technique should prove valuable in a variety of studies on sperm motility, capacitation and fertilization, and could also be extended to other cell systems

  4. Only in Canada: A Study of National Market Potential for Christian Higher Education Canada (CHEC) Institutions

    Science.gov (United States)

    Hiebert, Al

    2011-01-01

    In July 2007 Ipsos Reid delivered to Christian Higher Education Canada (CHEC) a report entitled "Christian Post-Secondary Education in Canada, Phase 3: Defining the Market". This article is a selective summary of the full 353-page report. It tabulates and analyzes findings from 1,000 phone interviews and 6,689 online surveys from six…

  5. Canada's gas taxes = highway robbery

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-05-01

    This report was prepared for the second annual 'gas honesty day' (May 18, 2000) in an effort to draw attention to the frustration of Canadian taxpayers with gasoline retailers and the petroleum industry for the inordinately and unjustifiably high prices for gasoline at the pump. The report points out that the public outcry is, in fact, misdirected since the largest profiteers at the pumps, the federal government, remains largely unscathed. It is alleged in the report that gas taxes are tantamount to highway robbery. Ostensibly collected for road construction and maintenance, of the almost $ 5 billion collected in 1999, only a paltry $ 194 million was returned to the provinces for roadway and highway spending. The 10-year average of federal returns to the the provinces from tax on gasoline is a meager 4.7 per cent, which fell even further to 4.1 per cent in 1998-1999. Gasoline tax revenues continue to climb, while government commitment to real roadway and highway spending continues to decline. This document attempts to shed some light on the pricing structure for gasoline. Without defending or explaining the non-tax portion of the pump price charged by Canada's oil companies, which is a task for the oil companies to undertake, the document makes a concerted effort to raise public awareness and focus public attention on government's involvement, namely that gas taxes represent on average about 50 per cent of the pump price and that the majority of the taxes collected are not put back into road and highway improvements. The Canadian Taxpayers Federation, authors of this report, expect that by focusing debate on the issue of gasoline taxes a broad support for a lowering of the overall tax burden on motorists will result. Among other things, the CTF advocates reduction of federal and provincial fuel taxes to levels commensurate with highway funding; dedication of fuel tax revenues to highway construction and maintenance; elimination of the sales and goods

  6. Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling

    Directory of Open Access Journals (Sweden)

    Youn Kyung Choi

    2014-01-01

    Full Text Available Cancer inflammation promotes cancer progression, resulting in a high risk of cancer. Here, we demonstrate that our new herbal extract, SH003, suppresses both tumor growth and metastasis of MDA-MB-231 breast cancer cells via inhibiting STAT3-IL-6 signaling path. Our new herbal formula, SH003, mixed extract from Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii Maximowicz, suppressed MDA-MB-231 tumor growth and lung metastasis in vivo and reduced the viability and metastatic abilities of MDA-MB-231 cells in vitro. Furthermore, SH003 inhibited STAT3 activation, which resulted in a reduction of IL-6 production. Therefore, we conclude that SH003 suppresses highly metastatic breast cancer growth and metastasis by inhibiting STAT3-IL-6 signaling path.

  7. Opportunities in Canada's growing wind energy industry

    International Nuclear Information System (INIS)

    Lovshin Moss, S.; Bailey, M.

    2006-01-01

    Investment in Canada's wind sector is projected to reach $8 billion by 2012, and growth of the sector is expected to create over 16,000 jobs. Canada's wind energy capacity grew by 54 per cent in 2005 alone, aided in part by supportive national policies and programs such as the Wind Power Production Incentive (WPPI); the Canadian Renewable Conservation Expense (CRCE) and Class 43.1 Capital Cost Allowance; and support for research and development. Major long-term commitments for clean power purchases, standard offer contracts and renewable portfolio standards in several provinces are encouraging further development of the wind energy sector. This paper argued that the development of a robust Canadian wind turbine manufacturing industry will enhance economic development, create opportunities for export; and mitigate the effects of international wind turbine supply shortages. However, it is not known whether Canadian wind turbine firms are positioned to capitalize on the sector's recent growth. While Canada imports nearly all its large wind turbine generators and components, the country has technology and manufacturing strengths in advanced power electronics and small wind systems, as well as in wind resource mapping. Wind-diesel and wind-hydrogen systems are being developed in Canada, and many of the hybrid systems will offer significant opportunities for remote communities and off-grid applications. Company partnerships for technology transfer, licensing and joint ventures will accelerate Canada's progress. A recent survey conducted by Industry Canada and the Canadian Wind Energy Association (CanWEA) indicated that the total impact of wind energy related expenditures on economic output is nearly $1.38 billion for the entire sector. Annual payroll for jobs in Canada was estimated at $50 million, and substantial employment growth in the next 5 years is expected. Canada offers a strong industrial supply base capable of manufacturing wind turbine generators and

  8. A multiple antibiotic and serum resistant oligotrophic strain, Klebsiella pneumoniae MB45 having novel dfrA30, is sensitive to ZnO QDs

    Directory of Open Access Journals (Sweden)

    Chakrabarti Pinak

    2011-05-01

    Full Text Available Abstract Background The aim of this study was to describe a novel trimethoprim resistance gene cassette, designated dfrA30, within a class 1 integron in a facultatively oligotrophic, multiple antibiotic and human serum resistant test strain, MB45, in a population of oligotrophic bacteria isolated from the river Mahananda; and to test the efficiency of surface bound acetate on zinc oxide quantum dots (ZnO QDs as bactericidal agent on MB45. Methods Diluted Luria broth/Agar (10-3 media was used to cultivate the oligotrophic bacteria from water sample. Multiple antibiotic resistant bacteria were selected by employing replica plate method. A rapid assay was performed to determine the sensitivity/resistance of the test strain to human serum. Variable region of class 1 integron was cloned, sequenced and the expression of gene coding for antibiotic resistance was done in Escherichia coli JM 109. Identity of culture was determined by biochemical phenotyping and 16S rRNA gene sequence analyses. A phylogenetic tree was constructed based on representative trimethoprim resistance-mediating DfrA proteins retrieved from GenBank. Growth kinetic studies for the strain MB45 were performed in presence of varied concentrations of ZnO QDs. Results and conclusions The facultatively oligotrophic strain, MB45, resistant to human serum and ten antibiotics trimethoprim, cotrimoxazole, ampicillin, gentamycin, netilmicin, tobramycin, chloramphenicol, cefotaxime, kanamycin and streptomycin, has been identified as a new strain of Klebsiella pneumoniae. A novel dfr gene, designated as dfrA30, found integrated in class 1 integron was responsible for resistance to trimethoprim in Klebsiella pneumoniae strain MB45. The growth of wild strain MB45 was 100% arrested at 500 mg/L concentration of ZnO QDs. To our knowledge this is the first report on application of ZnO quantum dots to kill multiple antibiotics and serum resistant K. pneumoniae strain.

  9. MicroRNA-101 inhibits cell proliferation, promotes cell apoptosis and increases sensitivity of breast cancer MDA-MB-231 cells to paclitaxel

    Directory of Open Access Journals (Sweden)

    Qiu-Lin Ke

    2016-02-01

    Full Text Available Objective: To explore the effect that miR-101 inhibits breast cancer MDA-MB-231 cell proliferation and increases the chemosensitivity of paclitaxel to breast cancer MDA-MB-231 cells and its influence on protein expression level of target gene Bcl2. Methods: miR-101 was artificially synthesized, it used liposome 3000 to transfect MDA-MB-231 cells, and experiment was divided into three groups: blank control group, negative control group and miR-101 group. MTT assay was used to detect the effect of miR-101 on MDA-MB-231 cell proliferation and chemosensitivity of paclitaxel-mediated MDA-MB-231 cells; flow cytometer was used to detect cell apoptosis. Real-time PCR and Western bloting were used to detect the changes of mRNA and protein expression levels of Bcl2. Results: After miR-101 transfected MDA-MB- 231 cells, cell proliferation ability significantly decreased compared with negative control group, and differences had statistical significance (P<0.01; after paclitaxel was used to process cells, IC50 of miR-101-processing group decreased by 2.45 times compared with blank control group, differences had statistical significance (P<0.05 and differences between blank control group and negative control group had no statistical significance; detection results by flow cytometer showed that both early-stage and late-stage apoptosis rates of MDA-MB-231 cells of miR-101 group were significantly higher than those of negative control group (P<0.05, and early-stage apoptosis rate was more significant (P<0.01; after transfection of miR-101, mRNA and protein levels of Bcl2 of MDA-MB-231 cells significantly decreased, and differences had statistical significance (P<0.05. Conclusion: miR-101 can inhibit breast cancer MDAMB- 231 cell proliferation through targeting and downregulating Bcl2, thereby increasing the chemosensitivity of breast cancer cells to paclitaxel and promoting cell apoptosis.

  10. Restructuring of Canada's nuclear utilities: recent developments

    International Nuclear Information System (INIS)

    Guindon, S.

    1998-01-01

    Business decisions relating to the electric power sector are a provincial responsibility in Canada. The federal government looks to the three nuclear utilities to manage their nuclear assets and maintain them in a way that maximizes their reliability, efficiency and overall performance. A significant development in Canada's nuclear sector in the past year was the Ontario Hydro Nuclear Asset Optimization Plan. Structural change in the North American electricity market is a major impetus for decisions regarding nuclear assets by Canada's electric power utilities. The Ontario government is now taking steps to introduce competition in the Ontario Electricity market. The province of New Brunswick, which has one reactor at Point Lepreau which supplies one-third of the province's electricity, is also taking measures to introduce competition in its electricity market. (author)

  11. A globally integrated climate policy for Canada

    International Nuclear Information System (INIS)

    Bernstein, S.; Brunnee, J.; Duff, D.G.; Green, A.J.

    2008-01-01

    This book explored policy ideas and options from various perspectives, including science, law, political science, economics and sociology. The costs, opportunities and imperatives to participate in international diplomatic initiatives were considered along with the opportunities of regional global carbon markets. Canada's current policy on climate change negotiations have been focused on domestic regulation and incentives for technological responses and the setting of a domestic carbon price. The sense of urgency about global warming was discussed and the need for action to respond to the threat of global climate change was emphasized. The book also reviewed Canada's role in international climate policies and presented parameters and imperatives for global regime building in Canada. Domestic policy tools were also reviewed along with policy obstacles and opportunities. refs., tabs., figs.

  12. Canada in the changing world economy

    Energy Technology Data Exchange (ETDEWEB)

    Wilkinson, B.W.

    1980-01-01

    A broad overview and a sectoral view of Canada's economic development concudes that expansion will slow down to two percent annually during the 1980s because of the decline in young people, immigrants, and women entering the labor force. Labor productivity will have to provide any growth in per capita incomes. Market expansion into developed countries has been difficult for Canada, although depreciation of the Canadian dollar was helpful. A general picture is drawn of Canada's present situation and the key issues the country faces as a part of the international community. Three strategies are suggested to strengthen the economic performance: restructure Canadian industry, increase aid to developing countries, and continue a devalued dollar while gradually easing the balance of payments deficit. 229 references, 21 tables. (DCK)

  13. The Hybridisation of Higher Education in Canada

    Directory of Open Access Journals (Sweden)

    Douglas Shale

    2002-01-01

    Full Text Available Canada's postsecondary institutions are becoming increasingly involved with technology enhanced learning, generally under the rubric of distance education. Growth and activity in distance education stems from rapid developments in communication and information technologies such as videoconferencing and the Internet. This case study focuses on the use of new technologies, primarily within the context of higher education institutions operating in Canada's English speaking provinces. Capitalising on the interactive capabilities of "new" learning technologies, some distance education providers are starting to behave more like conventional educational institutions in terms of forming study groups and student cohorts. Conversely, new telecommunications technologies are having a reverse impact on traditional classroom settings, and as a result conventional universities are beginning to establish administrative structures reflective of those used by distance education providers. When viewed in tandem, these trends reflect growing convergence between conventional and distance learning modes, leading to the hybridisation of higher education in Canada.

  14. Report on external occupational dosimetry in Canada

    International Nuclear Information System (INIS)

    1995-12-01

    In light of the new recommendations of the ICRP in Report 60 on dose quantities and dose limits, this working group was set up to examine the implications for external dosimetry in Canada. The operational quantities proposed by the ICRU are discussed in detail with regard to their applicability in Canada. The current occupational dosimetry services available in Canada are described as well as the several performance intercomparisons that have been carried out within the country as well as internationally. Recommendations are given with respect to standards for dosimetry, including accuracy and precision. More practical advice is given on the choice of dosimeter to use for external dosimetry, frequency of monitoring, and who should be monitored. Specific advice is given on the monitoring of pregnant workers and problem of non-uniform irradiation. Accident and emergency dosimetry are dealt with briefly. Suggestions are given regarding record keeping both for employers and for the national dose registry. 48 refs., 6 tabs., 1 fig

  15. Hard choices : climate change in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Coward, H.; Weaver, A.J. (eds.)

    2004-07-01

    This book explains the nature of climate change, the options to respond to it and the virtues of Canada's commitment to the Kyoto Protocol. It includes a collection of essays by prominent Canadian scientists and scholars who discuss the impacts of climate change on Canada from physical, social, technological, economic and political perspectives. Climate change assessments have been made possible by monitoring and recording changes in atmospheric concentrations of greenhouse gases. As a result of these assessments, climate change has become an issue on policy agendas. Advanced computer models have convinced much of the scientific community that climate change will bring with it droughts, floods, hurricanes, forest fires, ice storms, blackouts, and increased warming in countries in high latitudes, including Canada, despite remaining uncertainties about how human activities will affect the climate. The authors cautioned that climate change response strategies can only be refined once these uncertainties are significantly reduced. refs., tabs., figs.

  16. Do we expand the petrochemical industry in Canada or sell our ethane/NGL south of the border?

    International Nuclear Information System (INIS)

    Schultz, J.

    1996-01-01

    The supply and demand for Canadian natural gas liquids (NGL) was discussed. For the supply issue, the CERI forecast showed that there will be growing surpluses of NGL in Canada with available incremental volumes increased from 26 Mb/d in 1995 to 74 Mb/d in 2005. The majority of this volume is ethane, which will not be extracted without new markets. The challenge for ethane is to find new pipeline opportunities that would provide better economics. If ethane is to be exported, new grassroots pipelines will have to be constructed. Evaluation of existing capacities, such as the Cochin and Interprovincial pipeline systems, should be the first logical step. A recent announcement of the Northern Area Transportation System (NATS), a natural gas pipeline from N.E. British Columbia to Chicago, was assessed. A new pipeline, however, was not considered feasible as long as the netback to producers or shippers after deducting the tariff is less than the netback received from current markets. It was concluded that the plentiful supply and extreme volatility in prices will make new pipeline projects difficult to market. Retaining ethane in Alberta for a growing petrochemicals industry appears to be, at least for the present, be a more acceptable alternative than shipping it to the US Gulf Coast. 8 figs

  17. Action plan for electric mobility in Canada

    International Nuclear Information System (INIS)

    Gilbert, R.; Cormier, A.; Lavallee, P.

    2005-01-01

    Electric mobility is an important emerging industry in Canada, where there is significant expertise in electric and hybrid vehicles, batteries, hybrid technologies, grid-connected technologies and fuel cell vehicles. This paper presented a case for the formation of Electric Mobility Canada, a proposed network of private companies and public sector agencies that aims to stimulate industry and provide support to government agencies involved with meeting Canada's obligations under the Kyoto Protocol, as well as in new industry sectors. The environmental, health, economic and industrial benefits of electric mobility were outlined. Current programs for electric mobility were reviewed, and details of financial incentives and initiatives were presented. An overview of electric mobility programs in the United States and Europe was provided. Research and development needs were evaluated. The former Electric Vehicle Association of Canada was discussed. An organizational structure for the proposed network was presented, along with a mission statement and outline of future goals. Recommendations for the future of the network included identifying short and long-term market opportunities for electric mobility technologies for all surface transport modes in Canada; determining research and development needs and appropriate funding and investment opportunities; determining other actions necessary to allow the electric mobility industry to play a growing role in meeting Canada's transport needs; and raising public awareness of the importance of electric mobility trends. It was concluded that the federal government should be approached for start-up funds for the network, which will be followed by further investment from provincial and business interests once the network is in place and functioning. 84 refs

  18. Petro-Canada annual report, 1992

    International Nuclear Information System (INIS)

    1993-01-01

    Petro-Canada was formed as Canada's national energy corporation by an act of Parliament in 1975. Operations began in January 1976, and the company was privatized in July 1991. In 1992, Petro-Canada markedly improved its operating performance by sharply cutting operating and overhead costs. Strategy in the company's resource division was refocused to concentrate future investment in western Canada light oil and natural gas and in Grand Banks light oil. Petro-Canada sold a 5% interest in the Syncrude oil sands project for $132 million as part of its plan to rebalance its portfolio. In the products division, Petro-Canada is reducing capacity and eliminating inefficient parts of its marketing network as a response to low demand. Operating earnings improved $252 million to reach $109 million, versus a $143 million loss in 1991. Net earnings were $9 million, compared to a $598 million loss in 1991. Total oil and natural gas liquids production was 80,000 bbl/d and natural gas production was 517 million ft 3 /d. Refined product sales were 43,000 m 3 /d at an average refinery utilization of 72%. Proved oil and natural gas liquids reserves were 417 million bbl and proved natural gas reserves were 2.4 trillion ft 3 . Debt was reduced by almost $700 million during 1992. The year's activities in production and sales of natural gas, synthetic and natural crude oil, gasoline, and oil sands are summarized. A 6-year operating and financial summary is included, along with a financial statement. 11 figs., 17 tabs

  19. Measurements of the neutron energy spectra in the core of IPEN/MB-01 reactor; Medida do espectro de energia dos neutrons no nucleo do reator IPEN/MB-01

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Fernando Prat Goncalves

    2006-07-01

    This work presents the neutron spectrum measurements in the Reactor IPEN/MB-01 using very thin activation detectors in the metallic form, in reactor core, in moderator region. An articulated device allows that the foils are inserted in the central position of reactor core, ensuring that all the foils are irradiated in the same position. The activation detectors of different materials such Au{sup 197}, Mg{sup 24}, Ti{sup 4}'8, In{sup 115}, Sc{sup 45} and others, were selected to cover a large range of neutron spectrum. After the irradiation, the activation detectors were submitted to a spectrometry gamma by using a system of counting with high purity Germanium, to obtain the saturation activity per target nuclide. The saturation activity is one of the main data of input of unfolding code SANDBP, that through an iterative adjustment, modify the spectrum that better agree with the dataset of code input, composition mainly for measure reaction rate per target nuclide and a initial input spectrum, calculated for Hammer-Technion code, supplying a solution spectrum. (author)

  20. Measurements of the neutron energy spectra in the core of IPEN/MB-01 reactor; Medida do espectro de energia dos neutrons no nucleo do reator IPEN/MB-01

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Fernando Prat Goncalves

    2006-07-01

    This work presents the neutron spectrum measurements in the Reactor IPEN/MB-01 using very thin activation detectors in the metallic form, in reactor core, in moderator region. An articulated device allows that the foils are inserted in the central position of reactor core, ensuring that all the foils are irradiated in the same position. The activation detectors of different materials such Au{sup 197}, Mg{sup 24}, Ti{sup 4}'8, In{sup 115}, Sc{sup 45} and others, were selected to cover a large range of neutron spectrum. After the irradiation, the activation detectors were submitted to a spectrometry gamma by using a system of counting with high purity Germanium, to obtain the saturation activity per target nuclide. The saturation activity is one of the main data of input of unfolding code SANDBP, that through an iterative adjustment, modify the spectrum that better agree with the dataset of code input, composition mainly for measure reaction rate per target nuclide and a initial input spectrum, calculated for Hammer-Technion code, supplying a solution spectrum. (author)

  1. Partnership project between Environment Canada and ECRC

    International Nuclear Information System (INIS)

    Duhaime, C.; Daigle, R.

    1996-01-01

    The partnership agreement between Environment Canada and Eastern Canada Response Ltd, (ECRC) which allows for rapid release of information to all levels of management in the event of an oil or chemical spill, was discussed. A geographic information system for emergency management, and an information sharing network is made available to all parties through Internet to assure a continuous exchange of information during an emergency. Mapping, surveying and information-exchange tools are designed for mutual integration and compatibility. The agreement was signed at the beginning of 1996 and the new system will be tested by occasional exercises beginning in September 1996. Modifications will be made as necessary. 5 figs

  2. Shell Canada Limited 1996 annual report

    International Nuclear Information System (INIS)

    1996-01-01

    Shell Canada Resources Limited is one of Canada's largest producers of crude oil, natural gas, natural gas liquids, sulphur and bitumen. This annual report for 1996 presented a summary review of operations and a summary of the Company's audited consolidated financial statements. Overall, the resources business delivered exceptional results in 1996. The oil products and chemicals businesses did not perform as well as expected. This less than satisfactory performance of the oil products and chemicals divisions of the the Company is reflected in the financial returns which, after excluding revenues from asset sales, left operating earnings $ 59 million below those of 1996. tabs., figs

  3. The future of uranium in Canada

    International Nuclear Information System (INIS)

    Van Vliet, P.

    2010-01-01

    This paper examines issues relating to the future of uranium in Canada. It outlines the need for increased base-load electrical power generation to reach Canada's full economic potential of the resource sector. It outlines international comparisons, with emphasis on wind power generation as part of the energy mix of energy sources. It examines a broad overview of options and nuclear power; addressing the nuclear industry's safety as well as the unfounded continuing public fear of radiation. It also addresses nuclear waste management and disposal and the environmental assessment work done, leading up to the current Nuclear Waste Management Organization (NWMO). (author)

  4. Canada's upstream petroleum industry : 1997 perspective

    International Nuclear Information System (INIS)

    1997-06-01

    A review of the trends and activities in the upstream petroleum industry during 1996 were presented, emphasizing the significance of the industry' contribution to Canada's economy. Among the areas included were highlights of Canada's hydrocarbon reserves, conventional production, frontier production, and non-conventional (oil sands) production. New market opportunities and activities in the pipeline transportation sector were also discussed. Environmental issues including health and safety received due attention. In this regard, the industry's efforts to work with government and other stakeholders to ensure that requirements for land use are balanced with the need to protect wilderness and wildlife habitat, received special mention. 16 figs

  5. Canada's green plan - The second year. Summary

    International Nuclear Information System (INIS)

    1993-01-01

    Canada's Green Plan is the national strategy and action plan for sustainable development launched by the federal government. The Green Plan's goal is 'to secure for current and future generations a safe and healthy environment and a sound and prosperous economy.' It represents a fundamental shift in the way the federal government views economic development and environmental protection: they are inextricably linked; both are critical to the health and well-being of Canadians. Substantial development has been made in Canada, with advances being made on the Green Plan's short-term objectives and on our longer term priorities

  6. Overexpression of p65 attenuates celecoxib-induced cell death in MDA-MB-231 human breast cancer cell line

    Directory of Open Access Journals (Sweden)

    Wang Ling

    2013-02-01

    Full Text Available Abstract Background Celecoxib is a selective cyclooxygenase (COX-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation of NF-κB signaling. The NF-κB p65/RelA subunit may play a role in cell death through the activation of anti-apoptotic target genes including the inhibitor of apoptosis (IAP and Bcl-2 families, and inhibition of protein kinase B/Akt. The aim of the present study was to investigate p65 as the potential target of celecoxib treatment and determine whether p65 overexpression can override the inhibitory effect of celecoxib on NF-κB activity and affect cell survival. Methods The effects of p65 overexpression on celecoxib-inhibited NF-κB transcriptional activity were examined by western blotting, electrophoretic mobility shift assay (EMSA and luciferase reporter gene assay. Cell viability and cell death were evaluated by the 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazoliumbromide (MTT assay, and the levels of cleaved poly(ADP-ribose polymerase (PARP and caspase. Anti-apoptotic NF-κB target genes and cell cycle regulators were examined by western blotting to screen for the expression of target genes under direct regulation by p65. Results Overexpression of p65 increased NF-κB transcriptional activity and interfered with celecoxib-mediated apoptosis as assessed by MTT assay and caspase-3, caspase-9, and PARP expressions. Exogenously overexpressed p65 upregulated NF-κB-responsive genes, including anti-apoptotic genes such as survivin and XIAP, and the cell cycle regulatory gene cyclin D1. However, p65 overexpression did not affect celecoxib-induced p-Akt inactivation, suggesting that celecoxib might have separate molecular mechanisms for regulating Akt signaling independently of its inhibition of NF-κB transcriptional

  7. Regional habitat needs of a nationally listed species, Canada Warbler (Cardellina canadensis, in Alberta, Canada

    Directory of Open Access Journals (Sweden)

    Jeffrey R. Ball

    2016-12-01

    Full Text Available Understanding factors that affect the distribution and abundance of species is critical to developing effective management plans for conservation. Our goal was to quantify the distribution and abundance of Canada Warbler (Cardellina canadensis, a threatened old-forest associate in Alberta, Canada. The Canada Warbler has declined across its range, including in Alberta where habitat loss and alteration from urban expansion, forestry, and energy development are changing the forest landscape. We used 110,427 point count survey visits from 32,287 unique survey stations to model local-level (150-m radius circular buffers and stand-level (564-m radius circular buffers habitat associations of the Canada Warbler. We found that habitat supporting higher densities of Canada Warblers was locally concentrated yet broadly distributed across Alberta's boreal forest region. Canada Warblers were most commonly associated with older deciduous forest at the local scale, particularly near small, incised streams, and greater amounts of deciduous forest at the stand scale. Predicted density was lower in other forest types and younger age classes measured at the local scale. There was little evidence that local-scale fragmentation (i.e., edges created by linear features influenced Canada Warbler abundance. However, current forestry practices in the province likely will reduce the availability of Canada Warbler habitat over time by cutting old deciduous forest stands. Our results suggest that conservation efforts aimed at Canada Warbler focus on retaining large stands of old deciduous forest, specifically stands adjacent to streams, by increasing the width of deciduous retention buffers along streams during harvest and increasing the size and number of old forest residual patches in harvested stands.

  8. 78 FR 16493 - ExxonMobil Canada Energy, Flint Hills Resources Canada, LP, Imperial Oil, NOVA Chemical (Canada...

    Science.gov (United States)

    2013-03-15

    .... Paul Park Refining Co. LLC, Suncor Energy Marketing, Inc., United Refining Company v. Enbridge Energy..., Inc., Phillips 66 Canada ULC, St. Paul Park Refining Co. LLC, Suncor Energy Marketing, Inc., and... assistance with any FERC Online service, please email [email protected] , or call (866) 208-3676...

  9. Fe3O4@SiO2@CS-TETA functionalized graphene oxide for the adsorption of methylene blue (MB) and Cu(II)

    Science.gov (United States)

    Wang, Fan; Zhang, Lijuan; Wang, Yeying; Liu, Xijian; Rohani, Sohrab; Lu, Jie

    2017-10-01

    The graphene oxide (GO) functionalized by Fe3O4@SiO2@CS-TETA nanoparticles, Fe3O4@SiO2@CS-TETA-GO, was firstly fabricated in a mild way as a novel adsorbent for the removal of Cu(II) ions and methylene blue (MB) from aqueous solutions. The magnetic composites showed a good dispersity in water and can be conveniently collected for reuse through magnetic separation due to its excellent magnetism. When the Fe3O4@SiO2@CS- TETA-GO was used as an absorbent for the absorption of MB and Cu(II), the adsorption kinetics and isotherms data well fitted the pseudo-second-order model and the Langmuir model, respectively. Under the optimized pH and initial concentration, the maximum adsorption capacity was about 529.1 mg g-1 for MB in 20 min and 324.7 mg g-1 for Cu(II) in 16 min, respectively, exhibiting a better adsorption performance than other GO-based adsorbents reported recently. More importantly, the synthesized adsorbent could be effectively regenerated and repeatedly utilized without significant capacity loss after six times cycles. All the results demonstrated that Fe3O4@SiO2@CS-TETA-GO could be used as an excellent adsorbent for the adsorption of Cu(II) and MB in many fields.

  10. Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells.

    Science.gov (United States)

    Kwiatkowska, Ewa; Wojtala, Martyna; Gajewska, Agnieszka; Soszyński, Mirosław; Bartosz, Grzegorz; Sadowska-Bartosz, Izabela

    2016-02-01

    Novel approaches to cancer chemotherapy employ metabolic differences between normal and tumor cells, including the high dependence of cancer cells on glycolysis ("Warburg effect"). 3-Bromopyruvate (3-BP), inhibitor of glycolysis, belongs to anticancer drugs basing on this principle. 3-BP was tested for its capacity to kill human non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells. We found that 3-BP was more toxic for MDA-MB-231 cells than for MCF-7 cells. In both cell lines, a statistically significant decrease of ATP and glutathione was observed in a time- and 3-BP concentration-dependent manner. Transient increases in the level of reactive oxygen species and reactive oxygen species was observed, more pronounced in MCF-7 cells, followed by a decreasing tendency. Activities of glutathione peroxidase, glutathione reductase (GR) and glutathione S-transferase (GST) decreased in 3-BP treated MDA-MB-231 cells. For MCF-7 cells decreases of GR and GST activities were noted only at the highest concentration of 3-BP.These results point to induction of oxidative stress by 3-BP via depletion of antioxidants and inactivation of antioxidant enzymes, more pronounced in MDA-MB-231 cells, more sensitive to 3-BP.

  11. Normal results of post-race thallium-201 myocardial perfusion imaging in marathon runners with elevated serum MB creatine kinase levels

    International Nuclear Information System (INIS)

    Siegel, A.J.; Silverman, L.M.; Holman, B.L.

    1985-01-01

    Elevated cardiac enzyme values in asymptomatic marathon runners after competition can arise from skeletal muscle through exertional rhabdomyolysis, silent injury to the myocardium, or a combined tissue source. Peak post-race levels of the MB isoenzyme of creatine kinase are similar to values in patients with acute myocardial infarction. Previously reported normal results of infarct-avid myocardial scintigraphy with technetium 99m pyrophosphate in runners after competition suggest a non-cardiac source but cannot exclude silent injury to the myocardium. Therefore, thallium 201 myocardial perfusion imaging was performed in runners immediately after competition together with determination of sequential cardiac enzyme levels. Among 15 runners tested, the average peak in serum MB creatine kinase 24 hours after the race was 128 IU/liter with a cumulative MB creatine kinase release of 117 IU/liter; these values are comparable to those in patients with acute transmural myocardial infarction. Thallium 201 myocardial scintigraphic results were normal in five runners randomly selected from those who volunteered for determination of sequential blood levels. It is concluded that elevations of serum MB creatine kinase in marathon runners arise from a skeletal muscle source and that thallium 201 myocardial scintigraphy is useful to assess runners for myocardial injury when clinical questions arise

  12. Clinical evaluation of the CARDIAC STATus, a rapid immunochromatographic assay for simultaneous detection of elevated concentrations of CK-MB and myoglobin in whole blood

    NARCIS (Netherlands)

    Schouten, Y.; de Winter, R. J.; Gorgels, J. P.; Koster, R. W.; Adams, R.; Sanders, G. T.

    1998-01-01

    We studied the performance of the CARDIAC STATus, a new rapid, easy to perform qualitative whole blood bedside test for detection of elevated CK-MB and myoglobin in the emergency room. Blood samples from 182 consecutive patients with chest pain were drawn on admission and at five and seven hours

  13. Calculation of self-shielding coefficients, flux depression and cadmium factor for thermal neutron flux measurement of the IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Marques, Andre Luis Ferreira; Ting, Daniel Kao Sun; Mendonca, Arlindo Gilson

    1996-01-01

    A calculation methodology of Flux Depression, Self-Shielding and Cadmium Factors is presented, using the ANISN code, for experiments conducted at the IPEN/MB-01 Research Reactor. The correction factors were determined considering thermal neutron flux and 0.125 e 0.250 mm diameter of 197 Au wires. (author)

  14. Delayed O-methylation of l-DOPA in MB-COMT-deficient mice after oral administration of l-DOPA and carbidopa.

    Science.gov (United States)

    Tammimäki, Anne; Aonurm-Helm, Anu; Männistö, Pekka T

    2018-04-01

    1. Catechol-O-methyltransferase (COMT) is involved in the O-methylation of l-DOPA, dopamine, and other catechols. The enzyme is expressed in two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-COMT), which is anchored to intracellular membranes. 2. To obtain specific information on the functions of COMT isoforms, we studied how a complete MB-COMT deficiency affects the total COMT activity in the body, peripheral l-DOPA levels, and metabolism after l-DOPA (10 mg kg -1 ) plus carbidopa (30 mg kg -1 ) administration by gastric tube in wild-type (WT) and MB-COMT-deficient mice. l-DOPA and 3-O-methyl-l-DOPA (3-OMD) levels were assayed in plasma, duodenum, and liver. 3. We showed that the selective lack of MB-COMT did not alter the total COMT activity, COMT enzyme kinetics, l-DOPA levels, or the total O-methylation of l-DOPA but delayed production of 3-OMD in plasma and peripheral tissues.

  15. Identification of a 2 Mb human ortholog of Drosophila eyes shut/spacemaker that is mutated in patients with retinitis pigmentosa.

    NARCIS (Netherlands)

    Collin, R.W.J.; Littink, K.W.; Klevering, B.J.; Born, L.I. van den; Koenekoop, R.K.; Zonneveld-Vrieling, M.N.; Blokland, E.A.W.; Strom, T.M.; Hoyng, C.B.; Hollander, A.I. den; Cremers, F.P.M.

    2008-01-01

    In patients with autosomal-recessive retinitis pigmentosa (arRP), homozygosity mapping was performed for detection of regions harboring genes that might be causative for RP. In one affected sib pair, a shared homozygous region of 5.0 Mb was identified on chromosome 6, within the RP25 locus. One of

  16. Experimental demonstration of all-optical 781.25-Mb/s binary phase-coded UWB Signal Generation and Transmission

    DEFF Research Database (Denmark)

    Yu, Xianbin; Gibbon, Timothy Braidwood; Tafur Monroy, Idelfonso

    2009-01-01

    the requirements of Federal Communications Commission regulations. We experimentally demonstrated a 781.25-Mb/s UWB-over-fiber transmission system. A digital-signal-processing-based receiver is employed to calculate the bit-error rate. Our proposed system has potential application in future high-speed UWB impulse...

  17. Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation

    Science.gov (United States)

    Zhang, Yemin; Zhou, Yu; Li, Mingxin; Wang, Changhua

    2016-01-01

    Previous studies have evidenced that the anticancer potential of curcumin (diferuloylmethane), a main yellow bioactive compound from plant turmeric was mediated by interfering with PI3K/Akt signaling. However, the underlying molecular mechanism is still poorly understood. This study experimentally revealed that curcumin treatment reduced Akt protein expression in a dose- and time-dependent manner in MDA-MB-231 breast cancer cells, along with an activation of autophagy and suppression of ubiquitin-proteasome system (UPS) function. The curcumin-reduced Akt expression, cell proliferation, and migration were prevented by genetic and pharmacological inhibition of autophagy but not by UPS inhibition. Additionally, inactivation of AMPK by its specific inhibitor compound C or by target shRNA-mediated silencing attenuated curcumin-activated autophagy. Thus, these results indicate that curcumin-stimulated AMPK activity induces activation of the autophagy-lysosomal protein degradation pathway leading to Akt degradation and the subsequent suppression of proliferation and migration in breast cancer cell. PMID:26752181

  18. Fermentation products of solvent tolerant marine bacterium Moraxella spp. MB1 and its biotechnological applications in salicylic acid bioconversion.

    Directory of Open Access Journals (Sweden)

    Solimabi Wahidullah

    Full Text Available As part of a proactive approach to environmental protection, emerging issues with potential impact on the environment is the subject of ongoing investigation. One emerging area of environmental research concerns pharmaceuticals like salicylic acid, which is the main metabolite of various analgesics including aspirin. It is a common component of sewage effluent and also an intermediate in the degradation pathway of various aromatic compounds which are introduced in the marine environment as pollutants. In this study, biotransformation products of salicylic acid by seaweed, Bryopsis plumosa, associated marine bacterium, Moraxella spp. MB1, have been investigated. Phenol, conjugates of phenol and hydroxy cinnamic acid derivatives (coumaroyl, caffeoyl, feruloyl and trihydroxy cinnamyl with salicylic acid (3-8 were identified as the bioconversion products by electrospray ionization mass spectrometry. These results show that the microorganism do not degrade phenolic acid but catalyses oxygen dependent transformations without ring cleavage. The degradation of salicylic acid is known to proceed either via gentisic acid pathway or catechol pathway but this is the first report of biotransformation of salicylic acid into cinnamates, without ring cleavage. Besides cinnamic acid derivatives (9-12, metabolites produced by the bacterium include antimicrobial indole (13 and β-carbolines, norharman (14, harman (15 and methyl derivative (16, which are beneficial to the host and the environment.

  19. Metabolomic Dynamic Analysis of Hypoxia in MDA-MB-231 and the Comparison with Inferred Metabolites from Transcriptomics Data

    Directory of Open Access Journals (Sweden)

    Yufeng Jane Tseng

    2013-05-01

    Full Text Available Hypoxia affects the tumor microenvironment and is considered important to metastasis progression and therapy resistance. Thus far, the majority of global analyses of tumor hypoxia responses have been limited to just a single omics level. Combining multiple omics data can broaden our understanding of tumor hypoxia. Here, we investigate the temporal change of the metabolite composition with gene expression data from literature to provide a more comprehensive insight into the system level in response to hypoxia. Nuclear magnetic resonance spectroscopy was used to perform metabolomic profiling on the MDA-MB-231 breast cancer cell line under hypoxic conditions. Multivariate statistical analysis revealed that the metabolic difference between hypoxia and normoxia was similar over 24 h, but became distinct over 48 h. Time dependent microarray data from the same cell line in the literature displayed different gene expressions under hypoxic and normoxic conditions mostly at 12 h or earlier. The direct metabolomic profiles show a large overlap with theoretical metabolic profiles deduced from previous transcriptomic studies. Consistent pathways are glycolysis/gluconeogenesis, pyruvate, purine and arginine and proline metabolism. Ten metabolic pathways revealed by metabolomics were not covered by the downstream of the known transcriptomic profiles, suggesting new metabolic phenotypes. These results confirm previous transcriptomics understanding and expand the knowledge from existing models on correlation and co-regulation between transcriptomic and metabolomics profiles, which demonstrates the power of integrated omics analysis.

  20. Metabolomic Dynamic Analysis of Hypoxia in MDA-MB-231 and the Comparison with Inferred Metabolites from Transcriptomics Data

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, I-Lin [Department of Pharmacy, National Taiwan University, No. 1, Jen-Ai Road, Section 1 Taipei 10051, Taiwan (China); The Metabolomics Group, National Taiwan University, Taipei 106, Taiwan (China); Center for Genomic Medicine, National Taiwan University, Taipei 10051, Taiwan (China); Kuo, Tien-Chueh [The Metabolomics Group, National Taiwan University, Taipei 106, Taiwan (China); Graduate Institute of Biomedical Electronic and Bioinformatics, National Taiwan University, Room 410 BL Building, No. 1, Roosevelt Road, Sec. 4, Taipei 106, Taiwan (China); Ho, Tsung-Jung [The Metabolomics Group, National Taiwan University, Taipei 106, Taiwan (China); Department of Computer Science and Information Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan (China); Harn, Yeu-Chern [The Metabolomics Group, National Taiwan University, Taipei 106, Taiwan (China); Graduate Institute of Networking and Multimedia, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan (China); Wang, San-Yuan [The Metabolomics Group, National Taiwan University, Taipei 106, Taiwan (China); Department of Computer Science and Information Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan (China); Fu, Wen-Mei [Department of Pharmacology, National Taiwan University, 11 F No. 1 Sec. 1, Ren-ai Rd., Taipei 10051, Taiwan (China); Kuo, Ching-Hua, E-mail: kuoch@ntu.edu.tw [Department of Pharmacy, National Taiwan University, No. 1, Jen-Ai Road, Section 1 Taipei 10051, Taiwan (China); The Metabolomics Group, National Taiwan University, Taipei 106, Taiwan (China); Center for Genomic Medicine, National Taiwan University, Taipei 10051, Taiwan (China); Tseng, Yufeng Jane, E-mail: kuoch@ntu.edu.tw [Department of Pharmacy, National Taiwan University, No. 1, Jen-Ai Road, Section 1 Taipei 10051, Taiwan (China); The Metabolomics Group, National Taiwan University, Taipei 106, Taiwan (China); Center for Genomic Medicine, National Taiwan University, Taipei 10051, Taiwan (China); Graduate Institute of Biomedical Electronic and Bioinformatics, National Taiwan University, Room 410 BL Building, No. 1, Roosevelt Road, Sec. 4, Taipei 106, Taiwan (China); Department of Computer Science and Information Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan (China)

    2013-05-03

    Hypoxia affects the tumor microenvironment and is considered important to metastasis progression and therapy resistance. Thus far, the majority of global analyses of tumor hypoxia responses have been limited to just a single omics level. Combining multiple omics data can broaden our understanding of tumor hypoxia. Here, we investigate the temporal change of the metabolite composition with gene expression data from literature to provide a more comprehensive insight into the system level in response to hypoxia. Nuclear magnetic resonance spectroscopy was used to perform metabolomic profiling on the MDA-MB-231 breast cancer cell line under hypoxic conditions. Multivariate statistical analysis revealed that the metabolic difference between hypoxia and normoxia was similar over 24 h, but became distinct over 48 h. Time dependent microarray data from the same cell line in the literature displayed different gene expressions under hypoxic and normoxic conditions mostly at 12 h or earlier. The direct metabolomic profiles show a large overlap with theoretical metabolic profiles deduced from previous transcriptomic studies. Consistent pathways are glycolysis/gluconeogenesis, pyruvate, purine and arginine and proline metabolism. Ten metabolic pathways revealed by metabolomics were not covered by the downstream of the known transcriptomic profiles, suggesting new metabolic phenotypes. These results confirm previous transcriptomics understanding and expand the knowledge from existing models on correlation and co-regulation between transcriptomic and metabolomics profiles, which demonstrates the power of integrated omics analysis.

  1. Metabolomic Dynamic Analysis of Hypoxia in MDA-MB-231 and the Comparison with Inferred Metabolites from Transcriptomics Data

    International Nuclear Information System (INIS)

    Tsai, I-Lin; Kuo, Tien-Chueh; Ho, Tsung-Jung; Harn, Yeu-Chern; Wang, San-Yuan; Fu, Wen-Mei; Kuo, Ching-Hua; Tseng, Yufeng Jane

    2013-01-01

    Hypoxia affects the tumor microenvironment and is considered important to metastasis progression and therapy resistance. Thus far, the majority of global analyses of tumor hypoxia responses have been limited to just a single omics level. Combining multiple omics data can broaden our understanding of tumor hypoxia. Here, we investigate the temporal change of the metabolite composition with gene expression data from literature to provide a more comprehensive insight into the system level in response to hypoxia. Nuclear magnetic resonance spectroscopy was used to perform metabolomic profiling on the MDA-MB-231 breast cancer cell line under hypoxic conditions. Multivariate statistical analysis revealed that the metabolic difference between hypoxia and normoxia was similar over 24 h, but became distinct over 48 h. Time dependent microarray data from the same cell line in the literature displayed different gene expressions under hypoxic and normoxic conditions mostly at 12 h or earlier. The direct metabolomic profiles show a large overlap with theoretical metabolic profiles deduced from previous transcriptomic studies. Consistent pathways are glycolysis/gluconeogenesis, pyruvate, purine and arginine and proline metabolism. Ten metabolic pathways revealed by metabolomics were not covered by the downstream of the known transcriptomic profiles, suggesting new metabolic phenotypes. These results confirm previous transcriptomics understanding and expand the knowledge from existing models on correlation and co-regulation between transcriptomic and metabolomics profiles, which demonstrates the power of integrated omics analysis

  2. Inverse kinetics method with source term for subcriticality measurements during criticality approach in the IPEN/MB-01 research reactor

    International Nuclear Information System (INIS)

    Loureiro, Cesar Augusto Domingues; Santos, Adimir dos

    2009-01-01

    In reactor physics tests which are performed at the startup after refueling the commercial PWRs, it is important to monitor subcriticality continuously during criticality approach. Reactivity measurements by the inverse kinetics method are widely used during the operation of a nuclear reactor and it is possible to perform an online reactivity measurement based on the point reactor kinetics equations. This technique is successful applied at sufficiently high power level or to a core without an external neutron source where the neutron source term in point reactor kinetics equations may be neglected. For operation at low power levels, the contribution of the neutron source must be taken into account and this implies the knowledge of a quantity proportional to the source strength, and then it should be determined. Some experiments have been performed in the IPEN/MB-01 Research Reactor for the determination of the Source Term, using the Least Square Inverse Kinetics Method (LSIKM). A digital reactivity meter which neglects the source term is used to calculate the reactivity and then the source term can be determined by the LSIKM. After determining the source term, its value can be added to the algorithm and the reactivity can be determined again, considering the source term. The new digital reactivity meter can be used now to monitor reactivity during the criticality approach and the measured value for the reactivity is more precise than the meter which neglects the source term. (author)

  3. Experimental subcritical reactivity determinations employing APSD measurements with pulse mode detectors in the IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    Santos, Adimir dos; Lee, Seung Min; Diniz, Ricardo; Jerez, Rogerio

    2011-01-01

    This work aims to determine experimentally the subcritical reactivity levels of several configurations of the IPEN/MB-01 reactor in an approach based on the subcritical kinetic model developed by Gandini and Salvatores. The procedure employs the measurements of the APSD (Auto Power Spectral Density) using pulse mode detectors. The proposed approach is based only on measured quantities such as counting rates and the parameters arising from the least square approach of the APSD. Other difficult quantity such as detector efficiencies is not needed in the method. Several measurements of APSD were performed in varying degrees of sub-criticality (up to around -7000 pcm). The APSD data were least-square fitted to get the prompt decay mode (α). Beside the startup source, an external neutron sources of Am-Be was installed near the core in order to improve neutron count statistics. The final experimental results are of very good quality. The experiment shows clearly that the classical one point kinetic theory cannot describe the measured reactivity. MCNP K eff results were compared to the corresponding experimental results. The agreement was fairly good. (author)

  4. Fluvastatin mediated breast cancer cell death: a proteomic approach to identify differentially regulated proteins in MDA-MB-231 cells.

    Directory of Open Access Journals (Sweden)

    Anantha Koteswararao Kanugula

    Full Text Available Statins are increasingly being recognized as anti-cancer agents against various cancers including breast cancer. To understand the molecular pathways targeted by fluvastatin and its differential sensitivity against metastatic breast cancer cells, we analyzed protein alterations in MDA-MB-231 cells treated with fluvastatin using 2-DE in combination with LC-MS/MS. Results revealed dys-regulation of 39 protein spots corresponding to 35 different proteins. To determine the relevance of altered protein profiles with breast cancer cell death, we mapped these proteins to major pathways involved in the regulation of cell-to-cell signaling and interaction, cell cycle, Rho GDI and proteasomal pathways using IPA analysis. Highly interconnected sub networks showed that vimentin and ERK1/2 proteins play a central role in controlling the expression of altered proteins. Fluvastatin treatment caused proteolysis of vimentin, a marker of epithelial to mesenchymal transition. This effect of fluvastatin was reversed in the presence of mevalonate, a downstream product of HMG-CoA and caspase-3 inhibitor. Interestingly, fluvastatin neither caused an appreciable cell death nor did modulate vimentin expression in normal mammary epithelial cells. In conclusion, fluvastatin alters levels of cytoskeletal proteins, primarily targeting vimentin through increased caspase-3- mediated proteolysis, thereby suggesting a role for vimentin in statin-induced breast cancer cell death.

  5. Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail

    Directory of Open Access Journals (Sweden)

    Jeffrey R. Kugelman

    2015-09-01

    Full Text Available MB-003, a plant-derived monoclonal antibody cocktail used effectively in treatment of Ebola virus infection in non-human primates, was unable to protect two of six animals when initiated 1 or 2 days post-infection. We characterized a mechanism of viral escape in one of the animals, after observation of two clusters of genomic mutations that resulted in five nonsynonymous mutations in the monoclonal antibody target sites. These mutations were linked to a reduction in antibody binding and later confirmed to be present in a viral isolate that was not neutralized in vitro. Retrospective evaluation of a second independent study allowed the identification of a similar case. Four SNPs in previously identified positions were found in this second fatality, suggesting that genetic drift could be a potential cause for treatment failure. These findings highlight the importance selecting different target domains for each component of the cocktail to minimize the potential for viral escape.

  6. Criticality analysis of IPEN/MB-01 reactor using scale 6.0 and ENDF/B VII

    International Nuclear Information System (INIS)

    Cardoso, Fabiano S.; Salome, Jean; Pereira, Claubia; Fortini, Angela

    2015-01-01

    Since 1988, the IPEN/MB-01 reactor has been utilized for basic reactor physics research and as an instructional laboratory system. A series of experiments was conducted, and many of the components were evaluated in LEU-COMP-THERM-077 and LEU-COMP-THERM-089 benchmarks. In this work, we will compare the benchmark value references, with the newest ENDF/BVII libraries for neutron transport calculations through KENO-VI of the SCALE 6.0 codes. The 3D reactor model was simulated using 238 groups of energy and continuous energy libraries. The idea was to obtain, on this work, preliminary values of effective neutron multiplication factor to guide future work to get nuclear data as neutron flux, depleted fuel isotopic composition and generate homogenized and collapsed cross-sections libraries by few neutron energy groups to be used by other neutronic codes. It is expected that this study will produce a research source to be used as a support for future works employing such codes for nuclear safety criticality analysis and to verify compliance with the requirements of safety standards for nuclear fuel materials. (author)

  7. Anti-proliferative effect of biogenic gold nanoparticles against breast cancer cell lines (MDA-MB-231 & MCF-7)

    Science.gov (United States)

    K. S., Uma Suganya; Govindaraju, K.; Ganesh Kumar, V.; Prabhu, D.; Arulvasu, C.; Stalin Dhas, T.; Karthick, V.; Changmai, Niranjan

    2016-05-01

    Breast cancer is a major complication in women and numerous approaches are being developed to overcome this problem. In conventional treatments such as chemotherapy and radiotherapy the post side effects cause an unsuitable effect in treatment of cancer. Hence, it is essential to develop a novel strategy for the treatment of this disease. In the present investigation, a possible route for green synthesis of gold nanoparticles (AuNPs) using leaf extract of Mimosa pudica and its anticancer efficacy in the treatment of breast cancer cell lines is studied. The synthesized nanoparticles were found to be effective in killing cancer cells (MDA-MB-231 & MCF-7) which were studied using various anticancer assays (MTT assay, cell morphology determination, cell cycle analysis, comet assay, Annexin V-FITC/PI staining and DAPI staining). Cell morphological analysis showed the changes occurred in cancer cells during the treatment with AuNPs. Cell cycle analysis revealed apoptosis in G0/G1 to S phase. Similarly in Comet assay, there was an increase in tail length in treated cells in comparison with the control. Annexin V-FITC/PI staining assay showed prompt fluorescence in treated cells indicating the translocation of phosphatidylserine from the inner membrane. PI and DAPI staining showed the DNA damage in treated cells.

  8. 88 - 93 MB Ibrahim

    African Journals Online (AJOL)

    DR. AMIN

    The rest of which is locked up in oceans as salt water, polar ice-caps and glaciers and underground. Owing to increasing industrialization on one hand ..... equilibrium value is reached. This is in agreement with what has been observed earlier by Ibrahim et al., (2006). The pattern of the adsorption behavior with changes in.

  9. CK-MB Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  10. DRYLET™ MB BIO

    Science.gov (United States)

    Technical product bulletin: this agent (biological additive: microbiological culture) is used in oil spill cleanups on organic and hydrocarbon-based contamination. Can be applied to soil, open water, marsh, wetlands, or estuary areas of any salinity.

  11. Comparação entre troponina I cardíaca e CK-MB massa em síndrome coronariana aguda sem supra de ST

    Directory of Open Access Journals (Sweden)

    Elizabete Silva dos Santos

    2011-03-01

    Full Text Available FUNDAMENTO: Há incertezas do valor prognóstico comparativo entre troponina I cardíaca (cTnI e CK-MB em síndrome coronariana aguda (SCA. OBJETIVO: Comparar o valor prognóstico entre a cTnI e a CK-MB massa em pacientes com SCA sem supradesnível do segmento ST. MÉTODOS: Foram analisados 1.027 pacientes, de modo prospectivo, em um centro terciário de cardiologia. Combinações dos biomarcadores foram examinadas: cTnI normal, CK-MB massa normal (65,5%; cTnI normal, CK-MB massa elevada (3,9%; cTnI elevada, CK-MB massa normal (8,8%; cTnI elevada, CK-MB massa elevada (20,7%. Análise multivariada de variáveis clínicas, eletrocardiográficas e laboratoriais determinou o valor prognóstico independente dos biomarcadores para o evento de morte ou (reinfarto em 30 dias. RESULTADOS: Pacientes com pelo menos um biomarcador elevado foram mais idosos (p = 0,02 e do sexo masculino (p < 0,001. Uso prévio de aspirina (p = 0,001, betabloqueador (p = 0,003 ou estatina (p = 0,013 foi mais frequente naqueles sem elevação da cTnI. Pacientes com elevação de ambos os biomarcadores tinham mais depressão do segmento ST (p < 0,001 ou creatinina elevada (p < 0,001. Em análise multivariada com a inclusão da cTnI, a CK-MB massa não foi variável independente para o evento de morte ou (reinfarto em 30 dias (odds ratio [OR] 1,16; p = 0,71. Quando não se incluiu a cTnI, teve-se: idade (OR 1,07; p < 0,001; sexo masculino (OR 1,09; p = 0,77; diabete melito (OR 1,95; p = 0,02; acidente vascular cerebral prévio (OR 3,21; p = 0,008; creatinina elevada (OR 1,63; p = 0,002; elevação da CK-MB massa (OR 1,96; p = 0,03; estatística-C 0,77 (p < 0,001. CONCLUSÃO: Com dosagem da cTnI, a CK-MB massa pode ser dispensável para avaliação prognóstica. Na indisponibilidade da cTnI, a CK-MB massa é aceitável para decisão terapêutica.

  12. Evolution of thoracic surgery in Canada.

    Science.gov (United States)

    Deslauriers, Jean; Pearson, F Griffith; Nelems, Bill

    2015-01-01

    Canada's contributions toward the 21st century's practice of thoracic surgery have been both unique and multilayered. Scattered throughout are tales of pioneers where none had gone before, where opportunities were greeted by creativity and where iconic figures followed one another. To describe the numerous and important achievements of Canadian thoracic surgeons in the areas of surgery for pulmonary tuberculosis, thoracic oncology, airway surgery and lung transplantation. Information was collected through reading of the numerous publications written by Canadian thoracic surgeons over the past 100 years, interviews with interested people from all thoracic surgery divisions across Canada and review of pertinent material form the archives of several Canadian hospitals and universities. Many of the developments occurred by chance. It was the early and specific focus on thoracic surgery, to the exclusion of cardiac and general surgery, that distinguishes the Canadian experience, a model that is now emerging everywhere. From lung transplantation in chimera twin calves to ex vivo organ preservation, from the removal of airways to tissue regeneration, and from intensive care research to complex science, Canadians have excelled in their commitment to research. Over the years, the influence of Canadian thoracic surgery on international practice has been significant. Canada spearheaded the development of thoracic surgery over the past 100 years to a greater degree than any other country. From research to education, from national infrastructures to the regionalization of local practices, it happened in Canada.

  13. Climate change effects on regions of Canada

    International Nuclear Information System (INIS)

    Bruce, J.P.

    2002-01-01

    This report describes the major effects of climatic change being experienced in different parts of Canada, and emphasizes those that they are likely to become so severe that they may disrupt social, ecological and economic systems. The report notes that the driving force behind these impacts is change in temperature, precipitation, and in extreme weather events. The report strongly suggests that greenhouse gas emissions, particularly carbon dioxide, methane and nitrous oxide will likely continue to increase due to human activities such as burning of fossil fuels for heating, cooling and transportation. Loss of tropical forests is also listed as a cause for increased greenhouse gases. In order to reduce greenhouse gas emissions into the atmosphere, Canada must use energy much more efficiently, use more alternative renewable energy source and substitute natural gas for coal and oil whenever possible. It was emphasized that the ratification of the Kyoto Protocol would slow down the rate of increase of the world's greenhouse gas emissions, which in turn affect atmospheric concentrations. The author states that Canada's ratification of the Kyoto Protocol is key to global success, particularly since some countries have backed away from it and some are wavering. The report outlined the following major impacts of climate change in various parts of Canada: sea ice, permafrost, forest fires, transportation, toxic contaminants, storminess, precipitation, water supply, water quality, fisheries, hydropower, agriculture and human adaptation. refs., tabs

  14. Advancing ecohealth in Canada | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Canadian Community of Practice in Ecohealth (CoPEH-Canada) seeks solutions to inter-linked ... Successes and impact ... Read more about their contribution to EcoHealth 2012 and join them in Montréal when they host EcoHealth 2014.

  15. Canada and global warming: Meeting the challenge

    International Nuclear Information System (INIS)

    1991-01-01

    Canada accounts for ca 2% of total world emissions of greenhouse gases. Carbon dioxide emissions are by far the largest greenhouse gas source in Canada, primarily from energy consumption. On a per capita basis, Canada ranks second among industrialized countries in terms of energy related carbon dioxide emissions. Canada's northern geography and climate, its export-oriented economy with energy-intensive resource industries, and its relatively small population dispersed over a wide land mass contribute to this high per-capita value. The effects of global warming induced by greenhouse gases are outlined, including a reduction in water supplies, droughts affecting agriculture and forestry, and large-scale thawing of permafrost. A national strategy to respond to global warming has been developed which includes limiting and reducing greenhouse gas emissions, preparing for potential climatic changes, and improving scientific understanding and predictive capabilities with respect to climate change. Details of this strategy are outlined, including provincial and territorial strategies in partnership with the national strategy. 11 figs., 2 tabs

  16. Oil Production, Refining and Transportation in Canada

    Directory of Open Access Journals (Sweden)

    Igbal A. Guliyev

    2015-01-01

    Full Text Available The article deals with fuel and energy complex of Canada as one of the largest manufacturers of primary energy in the world, which provides up to 6 percent of the world energy supply. Only the Russian Federation, PRC, the United States of America and the Kingdom of Saudi Arabia have larger production volumes. However, oil plays the most significant role in Canada's energy exports. It is estimated that its proven reserves are sufficient to meet the demand for 140 years at current production rate. The relevance of the study, including the analysis of fuel and energy complex of Canada, is due to the fact that such comparison and synthesis of data on the amount of recoverable oil reserves, the volume of its production, imports, exports and transit of oil and oil products, the distribution of oil for transportation (via pipelines, rail, sea, road, strategic oil field, refining and transportation of oil and oil products development projects, as well as implementation of Canada's best practices in the Russian Federation, is being developed for the first time. In addition, the data given in previously published articles on the subject, due to the dynamic development of the industry, are obsolete and do not reflect the real situation.

  17. Radiation biology in Canada 1962-63

    International Nuclear Information System (INIS)

    Thacker, D.G.

    1963-02-01

    A survey of the research projects in radiation biology being carried out in Canada during the fiscal year 1962-63. The report includes the names of the investigators, their location, a brief description of the projects and information on the financial support being provided. A classification of the projects into areas of specific interest is also included. (author)

  18. A case of Cronkhite-Canada syndrome

    International Nuclear Information System (INIS)

    Hirohama, Shigeo; Soedjaro; Machida, Takashi

    1985-01-01

    A 75-year-old woman with Cronkhite-Canada syndrome underwent computed tomography (CT) and ultrasonography (US). CT and US provided useful information on pathologic conditions, including edema of the digestive mucosa, which characterize this syndrome. Clinical analysis of this syndrome in 77 Japanese cases reported in the literature was presented. (Namekawa, K.)

  19. Canada's nuclear achievement. Technical and economic perspectives

    International Nuclear Information System (INIS)

    Rummery, T.E.; Macpherson, J.A.

    1995-01-01

    Canada's leading role and eminent accomplishments in nuclear development now span more than half a century. They encompass aspects as diverse as the design and sale of nuclear power reactors and research reactor technology, to the establishment of a corps of scientists, engineers and technologists with the expertise to address a wide scope of important nuclear science issues. The success of a country of modest technical and financial resources, like Canada, in the highly technical and very competitive nuclear field is surprising to many Canadians, and does not fit the usual image we have of ourselves as 'drawers of water and hewers of wood'. For this reason alone, Canada's nuclear achievement makes an interesting and timely story. To address the many facets of Canada's nuclear activities over the past 50 years would obviously require space far beyond that available in this paper. We have therefore limited this review to highlights we judge to be the most pertinent and interesting from an historical, technical and economic perspective. We also indicate briefly our view of the future of nuclear power in the overall context of energy needs in a world that is becoming more industrial and increasingly environmentally conscious. (author) 22 refs., 7 figs

  20. Evolving Perspectives on Lyme Borreliosis in Canada

    Science.gov (United States)

    Sperling, JLH; Middelveen, MJ; Klein, D; Sperling, FAH

    2012-01-01

    With cases now documented in every province, Lyme borreliosis (LB) is emerging as a serious public health risk in Canada. Controversy over the contribution of LB to the burden of chronic disease is maintained by difficulty in capturing accurate Canadian statistics, especially early clinical cases of LB. The use of dogs as sentinel species demon-strates that potential contact with Borrelia burgdorferi spirochetes, as detected by C6 peptide, extends across the country. Dissemination of infected ticks by migratory birds and rapid establishment of significant levels of infection have been well described. Canadian public health response has focused on identification of established populations of the tick vectors, Ixodes scapularis and I. pacificus, on the assumption that these are the only important vectors of the disease across Canada. Strains of B. burgdorferi circulating in Canada and the full range of their reservoir species and coinfections remain to be explored. Ongoing surveys and historical records demonstrate that Borrelia-positive Ixodes species are regu-larly present in regions of Canada that have previously been considered to be outside of the ranges of these species in re-cent modeling efforts. We present data demonstrating that human cases of LB are found across the nation. Consequently, physician education and better early diagnoses are needed to prevent long term sequelae. An international perspective will be paramount for developing improved Canadian guidelines that recognize the complexity and diversity of Lyme borreliosis. PMID:23091570