The Nicest way to migrate your Windows computer

CERN Multimedia

2001-01-01

You are probably very conservative about your computer: the fewer changes you make, the fewer problems you'll have to face. But sometimes, you just have to leave your fears behind and take a plunge. And if you are a PC user at CERN, now is time to plunge into Windows 2000. However, you have nothing to fear, a team have been working for over a year with more than 50 servers on this project, called NICE 2000 - preparing for the LHC era while still maintaining NICE 95/NT. After Windows 3.0, 3.1, 95/NT, this is the 4th generation of NICE desktop services, relying on an infrastructure of more than 50 servers in production. Anyone coming from Windows 95 or NT will find a very similar interface to the one they are already familiar with. With Windows 2000, CERN users will discover a more stable and reliable working environment and will have access to all the latest applications. The Internet Services Team is responsible for the creation of all the infrastructure of NICE 2000. From left to right, standing: Ivan Delo...

CheD: chemical database compilation tool, Internet server, and client for SQL servers.

Science.gov (United States)

Trepalin, S V; Yarkov, A V

2001-01-01

An efficient program, which runs on a personal computer, for the storage, retrieval, and processing of chemical information, is presented, The program can work both as a stand-alone application or in conjunction with a specifically written Web server application or with some standard SQL servers, e.g., Oracle, Interbase, and MS SQL. New types of data fields are introduced, e.g., arrays for spectral information storage, HTML and database links, and user-defined functions. CheD has an open architecture; thus, custom data types, controls, and services may be added. A WWW server application for chemical data retrieval features an easy and user-friendly installation on Windows NT or 95 platforms.

Findings relating to the use of ACPI in Windows servers; Erfahrungen in der Anwendung von ACPI bei Windows-Servern

Energy Technology Data Exchange (ETDEWEB)

Huser, A.; Grieder, T.

2004-07-01

In a practical test, the possibilities and limits of the use of energy-saving sleep modes were compiled for servers of the lower price segment. Many of these servers are used by small to medium-sized enterprises and are left running around the clock, although they are not used at night or during the week-end. The implementation of the sleep modes is based on the so-called ACPI specification (Advanced Configuration and Power Interface), which was created by an industrial consortium. The most advanced of these is the implementation for the Windows Server 2003 operating system. With Linux, the sleep modes are not yet fully available. The test was therefore carried out with the Windows Server 2003 operating system. In many applications, and in particular when the servers are used as file or web servers, no operational disadvantages result from the use of the rest states. By making use of the lowest possible sleep mode during the night and at week-ends, the energy consumption of the server can be halved. For users, the results have been summarised in a two-page fact sheet, which is enclosed with this report as an appendix. (author)

Object-oriented designs for LHD data acquisitions using client-server model

International Nuclear Information System (INIS)

Kojima, M.; Nakanishi, H.; Hidekuma, S.

1999-01-01

The LHD data acquisition system handles >600 MB data per shot. The fully distributed data processing and the object-oriented system design are the main principles of this system. Its wide flexibility has been realized by introducing the object-oriented method into the data processing, in which the object sharing and class libraries will provide the unified way of data handling for the network client-server programming. The object class libraries are described in C++, and the network object sharing is provided through the commercial software named HARNESS. As for the CAMAC setup, the Java script can use the C++ class libraries and thus establishes the relationship between the object-oriented database and the WWW server. In LHD experiments, the CAMAC system and the Windows NT operating system are applied for digitizing and acquiring data, respectively. For the purpose of the LHD data acquisition, the new CAMAC handling software on Windows NT have been developed to manipulate the SCSI-connected crate controllers. The CAMAC command lists and diagnostic data classes are shared between client and server computers. A lump of the diagnostic data can be treated as part of an object by the object-oriented programming. (orig.)

Windows® Small Business Server 2008 Administrator's Pocket Consultant

CERN Document Server

Zacker, Craig

2009-01-01

Portable and precise, this pocket-sized guide delivers ready answers for administering Windows Small Business Server 2008. Zero in on core support tasks and tools using quick-reference tables, instructions, and lists. You'll get the focused information you need to solve problems and get the job done-whether at your desk or in the field. Get fast facts to: Plan, install, and configure a small business network Navigate the Windows SBS Console toolCreate and administer user and group accounts Manage automatic updates, disk storage, and shared printersConfigure mail settings and customize inte

Prepare for X-Win32 - the new X11 server software for Windows computers

CERN Multimedia

IT Department

2011-01-01

Starnet X-Win32 will replace Exceed as the X11 Server software on Windows computers by February 2012. X11 Server software allows a Windows user to have a graphical user interface on a remote Linux server. This change, initially motivated by a significant change of license conditions for Exceed, brings an easier integration of Windows and Linux logon mechanisms. At the same time, X-Win32 addresses the common use cases while providing a more intuitive configuration interface. CERN Predefined Connections will be available as before. They offer an easy way of starting applications on LXPLUS using PuTTY or starting the KDE, GNOME or ICE window managers. Since X-Win32 is better integrated with SSH and CERN Kerberos compared to Exceed, it is much simpler to set up secure access to Linux services. The decision to choose X-Win32 as the new X11 software resulted from an evaluation that involved various user communities and support teams. More information, including the documented use cases, is available at https://...

Object-oriented design for LHD data acquisition using client-server model

International Nuclear Information System (INIS)

Kojima, M.; Nakanishi, H.; Hidekuma, S.

1997-11-01

The LHD data acquisition system handles a huge amount of data exceeding over 600MB per shot. The fully distributed processing and the object-oriented system design are the main principles of this system. Its wide flexibility has been realized by introducing the object-oriented method into the data processing, in which the object-sharing and the class libraries will provide the unified way of data handling for both servers and clients program developments. The object class libraries are written in C ++ , and the network object-sharing is provided through a commercial software called HARNESS. As for the CAMAC setup, the Java script can use the C ++ class libraries and thus establishes the relationship between the object-oriented database and the WWW server. In LHD experiments, the CAMAC system and the Windows NT operating system are applied for digitizing and acquiring data, respectively. For the purpose of the LHD data acquisition, the new CAMAC handling softwares which work on Windows NT have been developed to manipulate the SCSI-connected crate controllers. The CAMAC command lists and diagnostic data classes are shared between clients and servers. A lump of diagnostic data mass is treated as a part of an object by the object-oriented programming. (author)

MCSA Windows Server 2012 R2 configuring advanced services study guide exam 70-412

CERN Document Server

Panek, William

2015-01-01

The bestselling MCSA study guide, with expert instruction andhands-on practice MCSA Windows Server 2012 R2 Configuring Advanced ServicesStudy Guide provides focused preparation for exam 70-412 and isfully updated to align with the latest Windows Server 2012 R2objectives. This comprehensive guide covers 100 percent of all examobjective domains, and includes hundreds of practice questions andanswers. You get access to video demonstrations, electronicflashcards, and practice exams, and hands-on exercises based onreal-world scenarios allow you to apply your skills to everydaytasks. Organized by o

MCSA Windows Server 2012 R2 complete study guide exams 70-410, 70-411, 70-412, and 70-417

CERN Document Server

Panek, William

2014-01-01

Prepare for the MCSA Windows Server 2012 R2 Exams Microsoft's new version of the MCSA certification for WindowsServer 2012 R2 requires passing three exams (or one Upgrade exam ifyou have your MCSA or MCITP in Windows Server 2008). Thisvalue-priced study guide includes more than 1,000 pages of qualityexam-prep content, covering 100% of the objective domains of allthree exams (as well as the Upgrade exam, 70-417). In addition, you get access to an interactive practice testenvironment with more than 500 questions, electronic flashcards,and videos showing how to perform the more difficult tasks.

A k-out-of-n reliability system with an unreliable server and phase type repairs and services: the (N,T policy

Directory of Open Access Journals (Sweden)

Srinivas R. Chakravarthy

2001-01-01

Full Text Available In this paper we study a k-out-of-n reliability system in which a single unreliable server maintains n identical components. The reliability system is studied under the (N,T policy. An idle server takes a vacation for a random amount of time T and then attends to any failed component waiting in line upon completion of the vacation. The vacationing server is recalled instantaneously upon the failure of the Nth component. The failure times of the components are assumed to follow an exponential distribution. The server is subject to failure with failure times exponentially distributed. Repair times of the component, fixing times of the server, and vacationing times of the server are assumed to be of phase type. Using matrix-analytic methods we perform steady state analysis of this model. Time spent by a failed component in service, total time in the repair facility, vacation time of the server, non-vacation time of the server, and time until failure of the system are all shown to be of phase type. Several performance measures are evaluated. Illustrative numerical examples are presented.

END OF NICE 95 AND NICE NT SERVICES

CERN Multimedia

2002-01-01

You are concerned by this article if you still use a computer running NICE 95 or NICE NT. As recommended by the Desktop Forum, NICE 95 and NT services will be stopped according to the following schedule: 31st January 2003: NICE 95/NT will be frozen. Applications will still be able to run, but the helpdesk will not address any NICE 95/NT problems anymore. It will not be possible to reinstall NICE 95/NT anymore. Disk images of the original Windows 95 and Windows NT CDs are available on the network, but it will be up to the user to create those CDs, reinstall the machine(s), as well as to locate and install: the required applications, the device drivers for special hardware, the necessary security patches, an anti-virus software (Operational Circular Nº5 of CERN's Computing Rules requires that Windows PCs are regularly checked for viruses). The original Windows 95 and Windows NT CD images can be obtained from http://cern.ch/win/services/installation/CDImages (please enter your NICE username and pa...

End of NICE 95 and NICE NT services

CERN Multimedia

2003-01-01

You are concerned by this article if you still use a computer running NICE 95 or NICE NT. As recommended by the Desktop Forum, NICE 95 and NT services will be stopped according to the following schedule: 31st January 2003: NICE 95/NT will be frozen. Applications will still be able to run, but the helpdesk will not address any NICE 95/NT problems anymore. It will not be possible to reinstall NICE 95/NT anymore. Disk images of the original Windows 95 and Windows NT CDs are available on the network, but it will be up to the user to create those CDs, reinstall the machine(s), as well as to locate and install: - the required applications, - the device drivers for special hardware, - the necessary security patches, - an anti-virus software (Operational Circular N 5 of CERN's Computing Rules (http://cern.ch/ComputingRules) requires that Windows PCs are regularly checked for viruses). The original Windows 95 and Windows NT CD images can be obtained from http://cern.ch/win/services/installation/CDImages (please...

End of NICE 95 and NICE NT services

CERN Document Server

2003-01-01

You are concerned by this article if you still use a computer running NICE 95 or NICE NT. As recommended by the Desktop Forum, NICE 95 and NT services will be stopped according to the following schedule: 31st January 2003: NICE 95/NT will be frozen. Applications will still be able to run, but the helpdesk will not address any NICE 95/NT problems anymore. It will not be possible to reinstall NICE 95/NT anymore. Disk images of the original Windows 95 and Windows NT CDs are available on the network, but it will be up to the user to create those CDs, reinstall the machine(s), as well as to locate and install: - the required applications, - the device drivers for special hardware, - the necessary security patches, - an anti-virus software (Operational Circular N 5 of CERN's Computing Rules (http://cern.ch/ComputingRules) requires that Windows PCs are regularly checked for viruses). The original Windows 95 and Windows NT CD images can be obtained from http://cern.ch/win/services/installation/CDImages (please ...

End of NICE 95 and NICE NT services (Reminder)

CERN Multimedia

2003-01-01

You are concerned by this article if you still use a computer running NICE 95 or NICE NT. As recommended by the Desktop Forum, NICE 95 and NT services are progressively phased out according to the following schedule: Since 31st January 2003: NICE 95/NT have been frozen. Applications are still able to run, but the helpdesk does not address any NICE 95/NT problems anymore. It is not possible to reinstall NICE 95/NT anymore. Disk images of the original Windows 95 and Windows NT CDs are available on the network, but it is up to the user to create those CDs, reinstall the machine(s), as well as to locate and install: - the required applications, - the device drivers for special hardware, - the necessary security patches, - an anti-virus software (Operational Circular N 5 of CERN's Computing Rules (http://cern.ch/ComputingRules) requires that Windows PCs are regularly checked for viruses). The original Windows 95 and Windows NT CD images can be obtained from http://cern.ch/win/services/installation/CDImages (ple...

TeraTools: Multiparameter data acquisition software for the Windows 95/NT OS

International Nuclear Information System (INIS)

Piercey, R.B.

1997-01-01

TeraTools, a general purpose, multiparameter, data acquisition application for Windows 95NT is described. It is based on the Kmax architecture which has been used since 1986 on the Macintosh computer at numerous industrial, education, and research sites world-wide. TeraTools includes high-level support for industry-standard modular instrumentation; a built-in scripting language; drivers for commercially available interfaces; hooks for external code extensions; event file sorting and replay; and a full set of histogramming and display tools. The environment is scalable and may be applied to problems involving a few parameters or many parameters

MS Windows domēna darbstacijas migrācijas iespējas no MS Windows XP uz MS Windows 7.

OpenAIRE

Zariņš, Valdis

2009-01-01

Kvalifikācijas darbā tiek aprakstītas MS Windows domēna darbstacijas migrācijas iespējas no MS Windows XP uz MS Windows 7, kā servera operētājsistēmas izmantojot tādus Microsoft produktus, kā Microsoft Windows Server 2003 un Microsoft Windows Server 2008. Kvalifikācijas darba teorētiskaja daļā tiek apskatīti Microsoft Windows 7 priekšrocības un uzlabojumus gan no darbstacijas lietotāja , gan no darbstacijas administratora puses. Ir aprakstītas Microsoft Windows Server 2008 jauninājumu ie...

Comparison of Certification Authority Roles in Windows Server 2003 and Windows Server 2008

Directory of Open Access Journals (Sweden)

A. I. Luchnik

2011-03-01

Full Text Available An analysis of Certification Authority components of Microsoft server operating systems was conducted. Based on the results main directions of development of certification authorities and PKI were highlighted.

CAMAC Driver Support for Windows NT trademark and Lunux trademark

International Nuclear Information System (INIS)

Slimmer, D.A.; Streets, J.M.

1999-01-01

CAMAC is a Modular Instrumentation and Digital Interface System defined as a standardized instrumentation system for Computer Automated Measurement and Control. CAMAC hardware and software has been defined by the NIM Committee (National Instrumentation Methods Committee) of the US Department of Energy and the ESONE Committee (European Standards on Nuclear Electronics Committee) of European Laboratories. Fermi National Accelerator Laboratory has for many years produced software packages that follow the ANSI/IEEE standard 758-1979 for a variety of computers, CAMAC controller interfaces, and operating systems. In order to enable the re-use of existing hardware and software, Fermilab now supports standard routine libraries and drivers for Windows NT 4.0 and the Linux operating systems for the Jorway 411s SCSI Bus CAMAC Driver[l] and the Jorway73A SCSI Bus CAMAC Crate Controller. A number of test stands and small experiments both on-site and off-site are using this software for their CAMAC data acquisition needs

Showstopper! the breakneck race to create Windows NT and the next generation at Microsoft

CERN Document Server

Zachary, G Pascal

2014-01-01

Showstopper is the dramatic, inside story of the creation of Windows NT, told by Wall Street Journal reporter G. Pascal Zachary. Driven by the legendary Bruce Cutler, a picked band of software engineers sacrifices almost everything in their lives to build a new, stable, operating system aimed at giving Microsoft a platform for growth through the next decade of development in the computing business.Comparable in many ways to the Pulitzer Prize-winning book The Soul of a New Machine by Tracy Kidder, Showstopper gets deep inside the process of software development, the lives and motivations of co

MS Windows domēna darbstaciju migrācija no MS Windows XP uz Windows Vista.

OpenAIRE

Tetere, Agate

2009-01-01

Kvalifikācijas darbā izpētīju darbstaciju migrācijas no Windows XP uz Windows Vista plusus un mīnusus. Darba gaitā tika veikti sekojoši uzdevumi: 1.Veikta Windows XP un Windows Vista darbstaciju instalācija, iestatījumu konfigurēšana un tika pārbaudīta sistēmas darbība 2.Veikta Windows Server 2003 un Windows Server 2008 instalācija, iestatījumu konfigurēšana un tika pārbaudīta sistēmas darbība 3.Izstrādāts migrācijas modelis 4.Veikta migrācijas optimizēšana 5.Veikta datu migrāc...

Microsoft Windows Server 2003 -palvelimen asentaminen ja käyttöönotto yrityksessä Postituspojat

OpenAIRE

Virtanen, Ilkka

2009-01-01

Opinnäytetyö toteutettiin yritysten Postituspojat ja HelmiTaito kanssa. Projektin tavoitteena oli saada Postituspojille toimiva uusi Microsoft Windows Server 2003 –palvelinympäristö. Uuden palvelinlaitteiston hankkiminen tuli Postituspojille ajankohtaiseksi yritykseen tehdyn tietoteknisen kartoituksen jälkeen. Tietoteknisen kartoituksen teki Petri Helmikkala yrityksestä HelmiTaito. Käyttöönotetussa palvelimessa tulee olla toiminnassa ainakin tiedostonjako, Active Directory sekä tulostimie...

Open client/server computing and middleware

CERN Document Server

Simon, Alan R

2014-01-01

Open Client/Server Computing and Middleware provides a tutorial-oriented overview of open client/server development environments and how client/server computing is being done.This book analyzes an in-depth set of case studies about two different open client/server development environments-Microsoft Windows and UNIX, describing the architectures, various product components, and how these environments interrelate. Topics include the open systems and client/server computing, next-generation client/server architectures, principles of middleware, and overview of ProtoGen+. The ViewPaint environment

Mastering Microsoft Exchange Server 2013

CERN Document Server

Elfassy, David

2013-01-01

The bestselling guide to Exchange Server, fully updated for the newest version Microsoft Exchange Server 2013 is touted as a solution for lowering the total cost of ownership, whether deployed on-premises or in the cloud. Like the earlier editions, this comprehensive guide covers every aspect of installing, configuring, and managing this multifaceted collaboration system. It offers Windows systems administrators and consultants a complete tutorial and reference, ideal for anyone installing Exchange Server for the first time or those migrating from an earlier Exchange Server version.Microsoft

Setup Instructions for the Applied Anomaly Detection Tool (AADT) Web Server

Science.gov (United States)

2016-09-01

tool has been developed for many platforms: Android , iOS, and Windows. The Windows version has been developed as a web server that allows the...Microsoft Windows. 15. SUBJECT TERMS Applied Anomaly Detection Tool, AADT, Windows, server, web service, installation 16. SECURITY CLASSIFICATION OF: 17...instructional information about identifying them as groups and individually. The software has been developed for several different platforms: Android

Mac OS X Lion Server For Dummies

CERN Document Server

Rizzo, John

2011-01-01

The perfect guide to help administrators set up Apple's Mac OS X Lion Server With the overwhelming popularity of the iPhone and iPad, more Macs are appearing in corporate settings. The newest version of Mac Server is the ideal way to administer a Mac network. This friendly guide explains to both Windows and Mac administrators how to set up and configure the server, including services such as iCal Server, Podcast Producer, Wiki Server, Spotlight Server, iChat Server, File Sharing, Mail Services, and support for iPhone and iPad. It explains how to secure, administer, and troubleshoot the networ

Windows® Internals

CERN Document Server

Russinovich, Mark E; Ionescu, Alex

2009-01-01

See how the core components of the Windows operating system work behind the scenes-guided by a team of internationally renowned internals experts. Fully updated for Windows Server 2008 and Windows Vista, this classic guide delivers key architectural insights on system design, debugging, performance, and support-along with hands-on experiments to experience Windows internal behavior firsthand.Delve inside Windows architecture and internals:Understand how the core system and management mechanisms work-from the object manager to services to the registryExplore internal system data structures usin

How to Configurate Oracle Enterprise Manager on Windows 2000 Server

Institute of Scientific and Technical Information of China (English)

无

2001-01-01

Oracle Enterprise Manager is a system management tool, which provides an integrated solution for centrally managing your heterogeneous environment Servers. Enterprise Manager combines a graphical Console, Oracle Management Servers, Oracle Intelligent Agents, common services, and tools to provide an integrated, comprehensive systems management platform for managing Oracle products, and is comprised of such as Data

Distributed mass data acquisition system based on PCs and windows NT for LHD fusion plasma experiment

International Nuclear Information System (INIS)

Nakanishi, H.; Kojima, M.; Ohsuna, M.; Komada, S.; Emoto, M.; Sugisaki, H.; Sudo, S.

2000-12-01

A new data acquisition and management system has been developed for the LHD experiment. It has the capability to process 100 MB - 1 GB raw data within a few tens seconds after every plasma discharge. It employs wholly distributed and loosely-tied parallel tasking structure through a fast network, and the cluster of the distributed database severs seems to be a virtual macro-machine as a whole. A PC/Windows NT computer is installed for each diagnostics data acquisition of about 30 kinds, and it controls CAMAC digitizers through the optical SCSI extenders. The diagnostic timing system consists of some kinds of VME modules that are installed to remotely control the diagnostic devices in real-time. They can, as a whole system, distribute the synchronous sampling clocks and programmable triggers for measurement digitizers. The data retrieving terminals can access database as application service clients, and are functionally separated from the data acquisition severs by way of the switching Ethernet. (author)

Experience with Server Self Service Center (S3C)

International Nuclear Information System (INIS)

Sucik, Juraj; Bukowiec, Sebastian

2010-01-01

CERN has a successful experience with running Server Self Service Center (S3C) for virtual server provisioning which is based on Microsoft (registered) Virtual Server 2005. With the introduction of Windows Server 2008 and its built-in hypervisor based virtualization (Hyper-V) there are new possibilities for the expansion of the current service. This paper describes the architecture of the redesigned virtual Server Self Service based on Hyper-V which provides dynamically scalable virtualized resources on demand as needed and outlines the possible implications on the future use of virtual machines at CERN.

Experience with Server Self Service Center (S3C)

CERN Multimedia

Sucik, J

2009-01-01

CERN has a successful experience with running Server Self Service Center (S3C) for virtual server provisioning which is based on Microsoft® Virtual Server 2005. With the introduction of Windows Server 2008 and its built-in hypervisor based virtualization (Hyper-V) there are new possibilities for the expansion of the current service. This paper describes the architecture of the redesigned virtual Server Self Service based on Hyper-V which provides dynamically scalable virtualized resources on demand as needed and outlines the possible implications on the future use of virtual machines at CERN.

Perbandingan proxy pada linux dan windows untuk mempercepat browsing website

Directory of Open Access Journals (Sweden)

Dafwen Toresa

2017-05-01

Full Text Available AbstrakPada saat ini sangat banyak organisasi, baik pendidikan, pemerintahan,  maupun perusahaan swasta berusaha membatasi akses para pengguna ke internet dengan alasan bandwidth yang dimiliki mulai terasa lambat ketika para penggunanya mulai banyak yang melakukan browsing ke internet. Mempercepat akses browsing menjadi perhatian utama dengan memanfaatkan teknologi Proxy server. Penggunaan proxy server perlu mempertimbangkan sistem operasi pada server dan tool yang digunakan belum diketahui performansi terbaiknya pada sistem operasi apa.  Untuk itu dirasa perlu untuk menganalisis performan Proxy server pada sistem operasi berbeda yaitu Sistem Operasi Linux dengan tools Squid  dan Sistem Operasi Windows dengan tool Winroute. Kajian ini dilakukan untuk mengetahui perbandingan kecepatan browsing dari komputer pengguna (client. Browser yang digunakan di komputer pengguna adalah Mozilla Firefox. Penelitian ini menggunakan 2 komputer klien dengan pengujian masing-masingnya 5 kali pengujian pengaksesan/browsing web yang dituju melalui proxy server. Dari hasil pengujian yang dilakukan, diperoleh kesimpulan bahwa penerapan proxy server di sistem operasi linux dengan tools squid lebih cepat browsing dari klien menggunakan web browser yang sama dan komputer klien yang berbeda dari pada proxy server sistem operasi windows dengan tools winroute.  Kata kunci: Proxy, Bandwidth, Browsing, Squid, Winroute AbstractAt this time very many organizations, both education, government, and private companies try to limit the access of users to the internet on the grounds that the bandwidth owned began to feel slow when the users began to do a lot of browsing to the internet. Speed up browsing access is a major concern by utilizing Proxy server technology. The use of proxy servers need to consider the operating system on the server and the tool used is not yet known the best performance on what operating system. For that it is necessary to analyze Performance Proxy

Aplikasi Billing Client/Server Dengan Mengunakan Microsoft Visual Basic 6.0

OpenAIRE

Sinukaban, Eva Solida

2010-01-01

Kajian ini bertujuan untuk membangun Billing Server yang gratis dalam jaringan Local dengan media transmisi berupa kabel UTP atau Wifi, Jaringan LAN yang dibangun ini merupakan jaringan client server yang memiliki server dengan sistem operasi yang dipakai adalah windows XP Service Pack 2. Tujuan pembuatan Aplikasi Billing Server ini adalah untuk dapat melakukan sharing data dan komunikasi antar komputer sehingga komputer-komputer tersebut dapat dimanfaatkan seoptimal mungkin baik dari sisi Se...

A relational database for physical data from TJ-II discharges

International Nuclear Information System (INIS)

Sanchez, E.; Portas, A.B.; Vega, J.

2002-01-01

A relational database (RDB) has been developed for classifying TJ-II experimental data according to physical criteria. Two objectives have been achieved: the design and the implementation of the database and the software tools for data access depending on a single software driver. TJ-II data were arranged in several tables with a flexible design, speedy performance, efficient search capacity and adaptability to meet present and future, requirements. The software has been developed to allow the access to the TJ-II RDB from a variety of computer platforms (ALPHA AXP/True64 UNIX, CRAY/UNICOS, Intel Linux, Sparc/Solaris and Intel/Windows 95/98/NT) and programming languages (FORTRAN and C/C++). The database resides in a Windows NT Server computer and is managed by Microsoft SQL Server. The access software is based on open network computing remote procedure call and follows client/server model. A server program running in the Windows NT computer controls data access. Operations on the database (through a local ODBC connection) are performed according to predefined permission protocols. A client library providing a set of basic functions for data integration and retrieval has been built in both static and dynamic link versions. The dynamic version is essential in accessing RDB data from 4GL environments (IDL and PV-WAVE among others)

Windows Security patch required

CERN Multimedia

3004-01-01

This concerns Windows PCs (XP, 2000, NT) which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables,... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

SUPPORT OF NEW COMPUTER HARDWARE AT LUCH'S MC and A SYSTEM: PROBLEMS AND A SOLUTION

International Nuclear Information System (INIS)

Fedoseev, Victor; Shanin, Oleg

2009-01-01

Microsoft Windows NT 4.0 operating system is the only software product certified in Russia for using in MC and A systems. In the paper a solution for allowing the installation of this outdated operating system on new computers is discussed. The solution has been successfully tested and has been in use at Luch's network since March 2008. Furthermore, it is being recommended for other Russian enterprises for the same purpose. Introduction Typically, the software part of a nuclear material control and accounting (MC and A) system consists of an operating system (OS), database management systems (DBMS), accounting program itself and database of nuclear materials. Russian regulations require the operating system and database for MC and A be certified for information security, and the whole system must pass an accreditation. Historically, the only certified operating system for MC and A still continues to be Microsoft Windows NT 4.0 Server/Workstation. Attempts to certify newer versions of Windows failed. Luch, like most other Russian sites, uses Microsoft Windows NT 4.0 and SQL Server 6.5. Luch's specialists have developed an application (LuchMAS) for accounting purposes. Starting from about 2004, some problems appeared in Luch's accounting system. They were related to the complexity of installing Windows NT 4.0 on new computers. At first, it was possible to solve the problem choosing computer equipment that is compatible with Windows NT 4.0 or selecting certain operating system settings. Over time, the problem worsened and now it is almost impossible to install Windows NT 4.0 on new computers. The reason is the lack of hardware drivers in the outdated operating system. The problem was serious enough that it could have affected the long-term sustainability of Luch's MC and A system if adequate alternate measures were not developed.

Migration towards Windows 2000/XP

International Nuclear Information System (INIS)

Gal, J.

2004-01-01

The article deals with interesting technical solutions used in the project 'Migration towards Windows 2000/XP', which was introduced by the company AITEN, Plc for companies SE Plc, SEPS Plc and TEKO, Plc in the period 2002 and 2003. The contents of the project was migration of about 100 servers and more than 4 000 PC to the Windows 2000 and XP environs. The result of the project is a unified and documented system in the field of file, print and small application servers and PC. It has enabled to increase the system reliability and availability, to decrease the total costs for administration and operation and to establish the steady environs for users of the applications. (author)

iPhone with Microsoft Exchange Server 2010 Business Integration and Deployment

CERN Document Server

Goodman, Steve

2012-01-01

iPhone with Microsoft Exchange Server 2010 - Business Integration and Deployment is a practical, step-by-step tutorial on planning, installing and configuring Exchange Server to deploy iPhones into your business. This book is aimed at system administrators who don't necessarily know about Exchange Server 2010 or ActiveSync-based mobile devices. A basic level of knowledge around Windows Servers is expected, and knowledge of smartphones and email systems in general will make some topics a little easier.

Information decision making support system RECASS-NT

International Nuclear Information System (INIS)

Shershakov, V.; Kosykh, V.; Borodin, R.

2003-01-01

Full text: The primary purpose of the DSS RECASS-NT is analysis and prediction of the situation in case of emergency at nuclear facilities (in early phases of an accident) including dose estimation and working out recommendations with regard to countermeasures to protect the public affected by the accident. The system was created to satisfy the following requirements: the system should be ale to operate in two modes: automatic and interactive; the system is based an the 'client-server' principle. Clients can interact with the system both locally and remotely; all calculations in the system are carried out on the server. The client part is responsible for interaction with the system user (including data presentation). Results of model calculations can be displayed during modeling (dynamically) and on completion of calculations; the information base of the system is the operational database, the systemic database and the database with calculation results; the system should enable parallel calculations, among them calculations by different scenarios for the same accident. The automatic mode involves running a specified chain of modules using appropriate scenarios, with a final result generated. The primary purpose of the automatic mode is conducting express-calculations when detailed information about emergency is unavailable. In the interactive mode selection and start-up of a chain of calculation modules, setting parameters for used models, their correction and other actions key for the system operations are performed by a system user (expert). There are no differences between the automatic and interactive modes in terms of storage of calculation results in the system and method of data transmission between the modules within the chain. The telecommunication subsystem (TCS) is designed to provide linkage between programs occurring an different computers and connected both in the local network and the telecommunication system EGASKRO and, possibly, commercial

Microsoft Exchange Server PowerShell cookbook

CERN Document Server

Andersson, Jonas

2015-01-01

This book is for messaging professionals who want to build real-world scripts with Windows PowerShell 5 and the Exchange Management Shell. If you are a network or systems administrator responsible for managing and maintaining Exchange Server 2013, you will find this highly useful.

Mac OS X Snow Leopard Server For Dummies

CERN Document Server

Rizzo, John

2009-01-01

Making Everything Easier!. Mac OS® X Snow Leopard Server for Dummies. Learn to::;. Set up and configure a Mac network with Snow Leopard Server;. Administer, secure, and troubleshoot the network;. Incorporate a Mac subnet into a Windows Active Directory® domain;. Take advantage of Unix® power and security. John Rizzo. Want to set up and administer a network even if you don't have an IT department? Read on!. Like everything Mac, Snow Leopard Server was designed to be easy to set up and use. Still, there are so many options and features that this book will save you heaps of time and effort. It wa

CACHING DATA STORED IN SQL SERVER FOR OPTIMIZING THE PERFORMANCE

Directory of Open Access Journals (Sweden)

Demian Horia

2016-12-01

Full Text Available This paper present the architecture of web site with different techniques used for optimize the performance of loading the web content. The architecture presented here is for e-commerce site developed on windows with MVC, IIS and Micosoft SQL Server. Caching the data is one technique used by the browsers, by the web servers itself or by proxy servers. Caching the data is made without the knowledge of users and need to provide to user the more recent information from the server. This means that caching mechanism has to be aware of any modification of data on the server. There are different information’s presented in e-commerce site related to products like images, code of product, description, properties or stock

Automated grading of homework assignments and tests in introductory and intermediate statistics courses using active server pages.

Science.gov (United States)

Stockburger, D W

1999-05-01

Active server pages permit a software developer to customize the Web experience for users by inserting server-side script and database access into Web pages. This paper describes applications of these techniques and provides a primer on the use of these methods. Applications include a system that generates and grades individualized homework assignments and tests for statistics students. The student accesses the system as a Web page, prints out the assignment, does the assignment, and enters the answers on the Web page. The server, running on NT Server 4.0, grades the assignment, updates the grade book (on a database), and returns the answer key to the student.

Microsoft Windows 2000 Router Configuration Guide

National Research Council Canada - National Science Library

Richburg, Florence

2001-01-01

The purpose of this guide is to provide technical guidance to network administrators of small to medium size networks in the configuration and integration of Microsoft Windows 2000 Server Router features...

Microsoft Exchange Server 2013 PowerShell cookbook

CERN Document Server

Andersson, Jonas

2013-01-01

This book is written in a Cookbook-style format and provides practical, immediately usable task-based recipes that show you how to manage and maintain your Microsoft Exchange Server 2013 environment with Windows PowerShell 3. Each chapter of the book is written so that it can be used as a desktop reference, or it can be read from beginning to end, allowing you to build a solid foundation for building scripts in your Exchange environment.This Cookbook is for messaging professionals who want to learn how to build real-world scripts with Windows PowerShell 3 and the Exchange Management Shell. If

Exchange Server 2010 Administration Real World Skills for MCITP Certification and Beyond (Exams 70-662 and 70-663)

CERN Document Server

Stidley, Joel

2010-01-01

A soup-to-nuts guide for messaging administrators. Exchange Server is the world's leading e-mail server software. Windows 7 and Server 2008 R2 have made changes that messaging administrators need to know and understand in their daily work with Exchange Server. This Sybex guide focuses on the skills, concepts, technologies, and potential pitfalls that admins in the trenches need to understand. It also provides the information they need to earn MCITP certification.: Updates in Exchange Server, the world's leading e-mail server software, require messaging administrators to update their knowledge

76 FR 9012 - Access to Confidential Business Information by Electronic Consulting Services, Inc.

Science.gov (United States)

2011-02-16

... development for special projects; and maintain hardware and software inventory of workstations. In accordance.../maintenance of servers and operating system software (UNIX, Linux, Windows XP/2003/2000/NT); installing..., Information Management Division (7407M), Office of Pollution Prevention and Toxics, Environmental Protection...

Medical Information Management System (MIMS) CareWindows.

Science.gov (United States)

Stiphout, R. M.; Schiffman, R. M.; Christner, M. F.; Ward, R.; Purves, T. M.

1991-01-01

The demonstration of MIMS/CareWindows will include: (1) a review of the application environment and development history, (2) a demonstration of a very large, comprehensive clinical information system with a cost effective graphic user server and communications interface. PMID:1807755

Microsoft® Office Communications Server 2007 R2 Resource Kit

CERN Document Server

Maximo, Rui; Ramanathan, Rajesh; Kamdar, Nirav

2009-01-01

In-depth, comprehensive, and fully revised for R2-this RESOURCE KIT delivers the information you need to deploy, manage, and troubleshoot Microsoft Office Communications Server 2007 R2. Get technical insights, scenarios, and best practices from those who know the technology best-the engineers who designed and developed it-along with 90+ Windows PowerShell™ scripts, bonus references, and other essential resources on CD. Get expert advice on how to: Plan server roles, infrastructure, topology, and securityDesign and manage enterprise instant messaging (IM), presence, and conferencing solutio

Remote Laboratory Java Server Based on JACOB Project

Directory of Open Access Journals (Sweden)

Pavol Bisták

2011-02-01

Full Text Available Remote laboratories play an important role in the educational process of engineers. This paper deals with the structure of remote laboratories. The principle of the proposed remote laboratory structure is based on the Java server application that communicates with Matlab through the COM technology for the data exchange under the Windows operating system. Java does not support COM directly so the results of the JACOB project are used and modified to cope with this problem. In laboratories for control engineering education a control algorithm usually runs on a PC with Matlab that really controls the real plant. This is the server side described in the paper in details. To demonstrate the possibilities of a remote control a Java client server application is also introduced. It covers communication and offers a user friendly interface for the control of a remote plant and visualization of measured data.

Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs

Science.gov (United States)

Saliba, Jason; Zabriskie, Ryan; Ghosh, Rajarshi; Powell, Bradford C; Hicks, Stephanie; Kimmel, Marek; Meng, Qingchang; Ritter, Deborah I; Wheeler, David A; Gibbs, Richard A; Tsai, Francis T F; Plon, Sharon E

2016-01-01

Background Mutations or alteration in expression of the 5’ nucleotidase gene family can confer altered responses to treatment with nucleoside analogs. While investigating leukemia susceptibility genes, we discovered a very rare p.L254P NT5C1A missense variant in the substrate recognition motif. Given the paucity of cellular drug response data from NT5C1A germline variation, we characterized p.L254P and eight rare variants of NT5C1A from genomic databases. Methods Through lentiviral infection, we created HEK293 cell lines that stably overexpress wildtype NT5C1A, p.L254P, or eight NT5C1A variants reported in the NHLBI Exome Variant server (one truncating and seven missense). IC50 values were determined by cytotoxicity assays after exposure to chemotherapeutic nucleoside analogs (Cladribine, Gemcitabine, 5-Fluorouracil). In addition, we used structure-based homology modeling to generate a 3D model for the C-terminal region of NT5C1A. Results The p.R180X (truncating), p.A214T, and p.L254P missense changes were the only variants that significantly impaired protein function across all nucleotide analogs tested (>5-fold difference versus WT; p<.05). Several of the remaining variants individually displayed differential effects (both more and less resistant) across the analogs tested. The homology model provided a structural framework to understand the impact of NT5C1A mutants on catalysis and drug processing. The model predicted active site residues within NT5C1A motif III and we experimentally confirmed that p.K314 (not p.K320) is required for NT5C1A activity. Conclusion We characterized germline variation and predicted protein structures of NT5C1A. Individual missense changes showed substantial variation in response to the different nucleoside analogs tested, which may impact patients’ responses to treatment. PMID:26906009

Proposal for the Award of a Blanket Purchase Contract for the Supply of PC Servers

CERN Document Server

2003-01-01

This document concerns the award of a contract for the supply and the hardware support of Windows compatible PC servers for a three-year period with a view to maintaining and evolving CERN's Windows infrastructure over the coming years. Following a market survey carried out among 38 firms in eleven Member States, a call for tenders (IT-2955/IT) was sent on 27 January 2003 to six firms in two Member States. By the closing date, CERN had received two tenders from two firms in one Member State. The Finance Committee is invited to agree to the negotiation of a three-year blanket purchase contract with ELONEX (CH), the lowest bidder complying with the specification, for the supply of Windows compatible PC servers for a total amount not exceeding 1 100 000 Swiss francs, not subject to revision. The firm has indicated the following distribution by country of the contract value covered by this adjudication proposal: GB - 100%.

Virtual network computing: cross-platform remote display and collaboration software.

Science.gov (United States)

Konerding, D E

1999-04-01

VNC (Virtual Network Computing) is a computer program written to address the problem of cross-platform remote desktop/application display. VNC uses a client/server model in which an image of the desktop of the server is transmitted to the client and displayed. The client collects mouse and keyboard input from the user and transmits them back to the server. The VNC client and server can run on Windows 95/98/NT, MacOS, and Unix (including Linux) operating systems. VNC is multi-user on Unix machines (any number of servers can be run are unrelated to the primary display of the computer), while it is effectively single-user on Macintosh and Windows machines (only one server can be run, displaying the contents of the primary display of the server). The VNC servers can be configured to allow more than one client to connect at one time, effectively allowing collaboration through the shared desktop. I describe the function of VNC, provide details of installation, describe how it achieves its goal, and evaluate the use of VNC for molecular modelling. VNC is an extremely useful tool for collaboration, instruction, software development, and debugging of graphical programs with remote users.

Implementación de los Servicios Terminal Server en un Sistema Corporativo

OpenAIRE

PUCHALT RODRÍGUEZ, ANA ELVIRA; GÓMEZ GARCÍA, PABLO JOSÉ

2014-01-01

Este proyecto final de carrera presenta el diseño e implementación de los sistemas de acceso a la red y de los servicios de Terminal Server en un sistema corporativo basado en Windows Server 2008 R2. Dado que no hay posibilidad de realizar el proyecto en un sistema corporativo real, se establecerá un sistema corporativo ficticio, donde cada uno de los trabajadores obtendrá acceso a su propia sesión con sus credenciales identificadoras. En esta sesión, se tendrá acceso a determi...

Implementace OpenVPN na platformě Windows CE

OpenAIRE

Ešner, Oldřich

2008-01-01

Motivací pro vznik této diplomové práce, která navazuje na stejnojmenný semestrální projekt, byl převod aplikace pro tvorbu virtuálních privátních sítí OpenVPN z operačního systému Windows XP na platformu Windows CE Embedded 6.0. Práce pojednává obecně o virtuálních privátních sítích, a podrobněji o jedné z jejich implementací - OpenVPN. Uvádí základní vlastnosti operačního systému Windows CE, dále popisuje princip ovladačů zařízení v operačních systémech na bázi Windows NT, používaný Windows...

Real time programming environment for Windows

Energy Technology Data Exchange (ETDEWEB)

LaBelle, D.R. [LaBelle (Dennis R.), Clifton Park, NY (United States)

1998-04-01

This document provides a description of the Real Time Programming Environment (RTProE). RTProE tools allow a programmer to create soft real time projects under general, multi-purpose operating systems. The basic features necessary for real time applications are provided by RTProE, leaving the programmer free to concentrate efforts on his specific project. The current version supports Microsoft Windows{trademark} 95 and NT. The tasks of real time synchronization and communication with other programs are handled by RTProE. RTProE includes a generic method for connecting a graphical user interface (GUI) to allow real time control and interaction with the programmer`s product. Topics covered in this paper include real time performance issues, portability, details of shared memory management, code scheduling, application control, Operating System specific concerns and the use of Computer Aided Software Engineering (CASE) tools. The development of RTProE is an important step in the expansion of the real time programming community. The financial costs associated with using the system are minimal. All source code for RTProE has been made publicly available. Any person with access to a personal computer, Windows 95 or NT, and C or FORTRAN compilers can quickly enter the world of real time modeling and simulation.

Publicación de materiales audiovisuales a través de un servidor de video-streaming Publication of audio-visual materials through a streaming video server

Directory of Open Access Journals (Sweden)

Acevedo Clavijo Edwin Jovanny

2010-07-01

Full Text Available Esta propuesta tiene como objetivo estudiar varias alternativas de servidores Streaming para determinar la mejor herramienta para el desarrollo de la publicación de material audiovisual educativo. Se evaluaron las plataformas más utilizadas teniendo en cuenta sus características y beneficios que tiene cada servidor entre las los cuales están: Hélix Universal Server, Windows Media Server de Microsoft, Peer Cast y Darwin Server. implementando un servidor con mayores capacidades y beneficios para la publicación de videos con fines académicos a través de la intranet de la Universidad Cooperativa de Colombia seccional Barrancabermeja This proposal has as an principal objective to study different alternatives for streaming servers to determine the best tool in the project’s development. Platforms most used were evaluated features and benefits in each served such as: Helix Universal Server, Microsoft Windows Media Server, Peer Cast and Darwin Server. Implementing a server with more capabilities and benefits for the publication of videos for academic purposes through the intranet of the Cooperative University of Colombia Barrancabermeja’s sectional

Görüntü Eşleme ve Genetik Algoritmalar Kullanarak Görüntü içinde Görüntü Arama

Directory of Open Access Journals (Sweden)

Mehmet Karakoc

2015-10-01

Full Text Available Bu çalışmada esas alınan problem, görüntü içinde görüntü aramayı etkin bir şekilde gerçekleştirebilmektir. Bu amaçla görüntü işleme kapsamında yer alan görüntü eşleme teknikleri ile arama algoritmaları birlikte kullanılmıştır. Görüntü eşleme için Yapay Sinir Ağları ile görüntünün ortalama renk değeri, görüntüdeki renk değerlerinin standart sapması, korelasyon ve görüntü kenar parametreleri gibi özellikler; görüntü arama için Genetik Algoritmalar kullanılmıştır. Bu çalışmada, akıllı arama algoritmaları, hızlı görüntü eşleme yöntemleri ve paralel programlama tekniklerine dayanan bütünleşik bir yöntem önerilmiş ve kullanılmıştır. Önerilen yöntem çok sayıda düşük ve yüksek çözünürlüklü referans ve şablon görüntü üzerinde test edilmiştir. Elde edilen sonuçlar önerilen yöntemin eşleşen görüntüleri elde etmede başarılı olduğunu ve toplam arama süresini azalttığını göstermiştir.

Analisis Perbandingan Load Balancing Web Server Tunggal Dengan Web Server Cluster Menggunakan Linux Virtual Server

OpenAIRE

Lukitasari, Desy; Oklilas, Ahmad Fali

2010-01-01

Virtual server adalah server yang mempunyai skalabilitas dan ketersedian yang tinggi yang dibangun diatas sebuah cluster dari beberapa real server. Real server dan load balancer akan saling terkoneksi baik dalam jaringan lokal kecepatan tinggi atau yang terpisah secara geografis. Load balancer dapat mengirim permintaan-permintaan ke server yang berbeda dan membuat paralel service dari sebuah cluster pada sebuah alamat IP tunggal dan meminta pengiriman dapat menggunakan teknologi IP load...

OPC Server and BridgeView Application for High Voltage Power Supply Lecroy 1458

CERN Document Server

Swoboda, D; CERN. Geneva

2000-01-01

Abstract The aim of this project was to develop an OPC server to communicate over an RS232 serial line. This communication media is commonly used with commercial instruments. The development was made for a High Voltage power supply in the context of the Alice [1] experiment. In addition, the structured modular concept will allow changing the transmission media or power supply type with little effort. The high voltage power supply should be accessible remotely through a network. OPC[2] is an acronym for OLE[3] for Process Control. OPC is based on the DCOM [3] communication protocol, which allows communication with any computer running a Windows based OS. This standard is widely used in industry to access device data through Windows applications. The concept is based on the client-server architecture. The hardware and the software architecture are described. Subsequently details of the implemented programs are given with emphasis on the possibility to replace parts of the software in order to use differ...

Region of interest and windowing-based progressive medical image delivery using JPEG2000

Science.gov (United States)

Nagaraj, Nithin; Mukhopadhyay, Sudipta; Wheeler, Frederick W.; Avila, Ricardo S.

2003-05-01

An important telemedicine application is the perusal of CT scans (digital format) from a central server housed in a healthcare enterprise across a bandwidth constrained network by radiologists situated at remote locations for medical diagnostic purposes. It is generally expected that a viewing station respond to an image request by displaying the image within 1-2 seconds. Owing to limited bandwidth, it may not be possible to deliver the complete image in such a short period of time with traditional techniques. In this paper, we investigate progressive image delivery solutions by using JPEG 2000. An estimate of the time taken in different network bandwidths is performed to compare their relative merits. We further make use of the fact that most medical images are 12-16 bits, but would ultimately be converted to an 8-bit image via windowing for display on the monitor. We propose a windowing progressive RoI technique to exploit this and investigate JPEG 2000 RoI based compression after applying a favorite or a default window setting on the original image. Subsequent requests for different RoIs and window settings would then be processed at the server. For the windowing progressive RoI mode, we report a 50% reduction in transmission time.

Clostridium botulinum strains producing BoNT/F4 or BoNT/F5.

Science.gov (United States)

Raphael, Brian H; Bradshaw, Marite; Kalb, Suzanne R; Joseph, Lavin A; Lúquez, Carolina; Barr, John R; Johnson, Eric A; Maslanka, Susan E

2014-05-01

Botulinum neurotoxin type F (BoNT/F) may be produced by Clostridium botulinum alone or in combination with another toxin type such as BoNT/A or BoNT/B. Type F neurotoxin gene sequences have been further classified into seven toxin subtypes. Recently, the genome sequence of one strain of C. botulinum (Af84) was shown to contain three neurotoxin genes (bont/F4, bont/F5, and bont/A2). In this study, eight strains containing bont/F4 and seven strains containing bont/F5 were examined. Culture supernatants produced by these strains were incubated with BoNT/F-specific peptide substrates. Cleavage products of these peptides were subjected to mass spectral analysis, allowing detection of the BoNT/F subtypes present in the culture supernatants. PCR analysis demonstrated that a plasmid-specific marker (PL-6) was observed only among strains containing bont/F5. Among these strains, Southern hybridization revealed the presence of an approximately 242-kb plasmid harboring bont/F5. Genome sequencing of four of these strains revealed that the genomic backgrounds of strains harboring either bont/F4 or bont/F5 are diverse. None of the strains analyzed in this study were shown to produce BoNT/F4 and BoNT/F5 simultaneously, suggesting that strain Af84 is unusual. Finally, these data support a role for the mobility of a bont/F5-carrying plasmid among strains of diverse genomic backgrounds.

Development in distributed beam-view

International Nuclear Information System (INIS)

Bhole, R.B.; Pal, Satbajit; Dasgupta, S.

2003-01-01

A computerized distributed beam-viewer has been developed using PC-add on image digitizer card plugged into a Pentium PC running Windows NT. Image Acquisition card (IMAQ-1408) from National Instruments is driven to digitise inputs from CCD cameras placed along the beam transport lines. The multiple clients situated across a switched Ethernet LAN, collects the data and displays beam-views on a desirable Window size. Only one privilege client at the control room has the selection facility of the channel (camera), whereas image display processing and storing facility are provided at all other clients end. The client server S/W written on Window SDK is implemented using Window Socket ver 2.0 library functions. (author)

UNIX secure server : a free, secure, and functional server example

OpenAIRE

Sastre, Hugo

2016-01-01

The purpose of this thesis work was to introduce UNIX server as a personal server but also as a start point for investigation and developing at a professional level. The objective of this thesis was to build a secure server providing not only a FTP server but also an HTTP server and a cloud system for remote backups. OpenBSD was used as the operating system. OpenBSD is a UNIX-like operating system made by hackers for hackers. The difference with other systems that might partially provid...

HTR-10 management information system

International Nuclear Information System (INIS)

Liu Ruoxiao; Wu Zhongwang; Xi Shuren

2000-01-01

The HTR-10 Management information system (REMIS) strengthens the managerial level and usage of the information of HTR-10, thereby enhances the ability and efficiency of the design and management work. REMIS is designed based on the Client/Server framework. Database management system is SQL Server 6.5 for NT, While the client side is developed by Borland C ++ Builder, and it is based on Windows 95/98. The network protocol is TCP/IP. REMIS collects date of the HTR-10 at four parameters: Reactor properties, Design parameters, Equipment properties Reactor system flow charts. Final discussing extended prospect of REMIS

Instant Windows PowerShell

CERN Document Server

Menon, Vinith

2013-01-01

Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. A practical, hands-on tutorial approach that explores the concepts of PowerShell in a friendly manner, taking an adhoc approach to each topic.If you are an administrator who is new to PowerShell or are looking to get a good grounding in these new features, this book is ideal for you. It's assumed that you will have some experience in PowerShell and Windows Server, as well being familiar with the PowerShell command-line.

Publicación de materiales audiovisuales a través de un servidor de video-streaming Publication of audio-visual materials through a streaming video server

OpenAIRE

Acevedo Clavijo Edwin Jovanny; Parra Toloza Dina Julieth; Winlker Hernadez Walter

2010-01-01

Esta propuesta tiene como objetivo estudiar varias alternativas de servidores Streaming para determinar la mejor herramienta para el desarrollo de la publicación de material audiovisual educativo. Se evaluaron las plataformas más utilizadas teniendo en cuenta sus características y beneficios que tiene cada servidor entre las los cuales están: Hélix Universal Server, Windows Media Server de Microsoft, Peer Cast y Darwin Server. implementando un servidor con mayores capacidades y beneficios par...

Porting linac application programs to a windowing environment

International Nuclear Information System (INIS)

Nonglaton, J.M.; Raich, U.

1992-01-01

We report our experience in porting Linac application programs written for Camac controlled hardware consoles to an X-Windows/Motif based workstation environment. Application programs acquire their parameter values from a front end computer (FEC), controlling the acceleration process, via a local area network. The timing for data acquisition and control is determined by the particle source timing. Two server programs on the FEC for repetitive acquisition and command-response mode will be described. The application programs on the workstations access a common parameter access server who establishes the necessary connection to the parameters on the FEC. It displays the parameter's current values and allows control through Motif widgets. An interactive synoptics editor and its corresponding driver program allow easy generation of synoptics displays and interaction through command panels. (author)

GeoServer cookbook

CERN Document Server

Iacovella, Stefano

2014-01-01

This book is ideal for GIS experts, developers, and system administrators who have had a first glance at GeoServer and who are eager to explore all its features in order to configure professional map servers. Basic knowledge of GIS and GeoServer is required.

Alignment-Annotator web server: rendering and annotating sequence alignments.

Science.gov (United States)

Gille, Christoph; Fähling, Michael; Weyand, Birgit; Wieland, Thomas; Gille, Andreas

2014-07-01

Alignment-Annotator is a novel web service designed to generate interactive views of annotated nucleotide and amino acid sequence alignments (i) de novo and (ii) embedded in other software. All computations are performed at server side. Interactivity is implemented in HTML5, a language native to web browsers. The alignment is initially displayed using default settings and can be modified with the graphical user interfaces. For example, individual sequences can be reordered or deleted using drag and drop, amino acid color code schemes can be applied and annotations can be added. Annotations can be made manually or imported (BioDAS servers, the UniProt, the Catalytic Site Atlas and the PDB). Some edits take immediate effect while others require server interaction and may take a few seconds to execute. The final alignment document can be downloaded as a zip-archive containing the HTML files. Because of the use of HTML the resulting interactive alignment can be viewed on any platform including Windows, Mac OS X, Linux, Android and iOS in any standard web browser. Importantly, no plugins nor Java are required and therefore Alignment-Anotator represents the first interactive browser-based alignment visualization. http://www.bioinformatics.org/strap/aa/ and http://strap.charite.de/aa/. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

A flexible and testable software architecture: applying presenter first to a device server for the DOOCS accelerator control system of the European XFEL

International Nuclear Information System (INIS)

Beckmann, A.; Karabekyan, S.; Pflüger, J.

2012-01-01

Presenter First (PF) uses a variant of Model View Presenter design pattern to add implementation flexibility and to improve testability of complex event-driven applications. It has been introduced in the context of GUI applications, but can easily be adapted to server applications. This paper describes how Presenter First methodology is used to develop a device server for the Programmable Logic Controls (PLC) of the European XFEL undulator systems, which are Windows PCs running PLC software from Beckhoff. The server implements a ZeroMQ message interface to the PLC allowing the DOOCS accelerator control system of the European XFEL to exchange data with the PLC by sending messages over the network. Our challenge is to develop a well-tested device server with a flexible architecture that allows integrating the server into other accelerator control systems like EPICS. (author)

NT2 derived neuronal and astrocytic network signalling.

Directory of Open Access Journals (Sweden)

Eric J Hill

Full Text Available A major focus of stem cell research is the generation of neurons that may then be implanted to treat neurodegenerative diseases. However, a picture is emerging where astrocytes are partners to neurons in sustaining and modulating brain function. We therefore investigated the functional properties of NT2 derived astrocytes and neurons using electrophysiological and calcium imaging approaches. NT2 neurons (NT2Ns expressed sodium dependent action potentials, as well as responses to depolarisation and the neurotransmitter glutamate. NT2Ns exhibited spontaneous and coordinated calcium elevations in clusters and in extended processes, indicating local and long distance signalling. Tetrodotoxin sensitive network activity could also be evoked by electrical stimulation. Similarly, NT2 astrocytes (NT2As exhibited morphology and functional properties consistent with this glial cell type. NT2As responded to neuronal activity and to exogenously applied neurotransmitters with calcium elevations, and in contrast to neurons, also exhibited spontaneous rhythmic calcium oscillations. NT2As also generated propagating calcium waves that were gap junction and purinergic signalling dependent. Our results show that NT2 derived astrocytes exhibit appropriate functionality and that NT2N networks interact with NT2A networks in co-culture. These findings underline the utility of such cultures to investigate human brain cell type signalling under controlled conditions. Furthermore, since stem cell derived neuron function and survival is of great importance therapeutically, our findings suggest that the presence of complementary astrocytes may be valuable in supporting stem cell derived neuronal networks. Indeed, this also supports the intriguing possibility of selective therapeutic replacement of astrocytes in diseases where these cells are either lost or lose functionality.

Beginning SQL Server Modeling Model-driven Application Development in SQL Server

CERN Document Server

Weller, Bart

2010-01-01

Get ready for model-driven application development with SQL Server Modeling! This book covers Microsoft's SQL Server Modeling (formerly known under the code name "Oslo") in detail and contains the information you need to be successful with designing and implementing workflow modeling. Beginning SQL Server Modeling will help you gain a comprehensive understanding of how to apply DSLs and other modeling components in the development of SQL Server implementations. Most importantly, after reading the book and working through the examples, you will have considerable experience using SQL M

Windows Server 2003 Active Directory Design and Implementation Creating, Migrating, and Merging Networks

CERN Document Server

Savill, John

2005-01-01

This book is for Windows network administrators, analysts, or architects,  with a grasp of the basic operations of Active Directory, and are looking for a book that goes beyond rudimentary operations. However, all of the concepts are explained from the g

Botulinum toxin (BoNT) and back pain.

Science.gov (United States)

Porta, Mauro; Maggioni, G

2004-02-01

Myofascial pain syndrome is defined as subacute or chronic pain with sensory, motor and autonomic symptoms referred from active trigger points with associated painful dysfunctions. Authors present the usefulness of botulinum toxin A or B (BoNT/A or BoNT/B) injected into target muscles since the toxin is capable of controlling not only the muscular spasm but mostly the pain by alternative mechanisms of action, which are discussed. Posology of BoNT, technical aspects and results are presented. BoNT represents an interesting and useful tool for an adequate management of patients with myofascial pain.

Mastering Lync Server 2010

CERN Document Server

Winters, Nathan

2012-01-01

An in-depth guide on the leading Unified Communications platform Microsoft Lync Server 2010 maximizes communication capabilities in the workplace like no other Unified Communications (UC) solution. Written by experts who know Lync Server inside and out, this comprehensive guide shows you step by step how to administer the newest and most robust version of Lync Server. Along with clear and detailed instructions, learning is aided by exercise problems and real-world examples of established Lync Server environments. You'll gain the skills you need to effectively deploy Lync Server 2010 and be on

MEMBANGUN SERVER BERBASIS LINUX PADA JARINGAN LAN DI LABOR SISTEM INFORMASI JURUSAN TEKNOLOGI INFORMASI POLITEKNIK NEGERI PADANG

Directory of Open Access Journals (Sweden)

Fifi Rasyidah

2014-03-01

Full Text Available The System Information Laboratory of Information Technology Department Polytechnic State of Padang has 30 units computer as education facilities to support learning process. All of computers used at same time in a learning section. This case causing trouble to monitoring each students activities. In order to get the solution for the lecturer, the writer then construct a server by using Linux operation system and client by using windows system operation in which Samba File Server is needed. By using this samba, the lecturer will be able to share the data and will be able to use the server as data storage media. Besides that, the writer will also use VNC (Virtual network connection to simplify the process of monitoring and supervising client working system. Based on the result gotten after the writer done some experiment, it can be concluded that Samba File Server can also be used after some configuration is applied on certain files. Moreover, the writer also conclude that VNC can control the entire of the client. The writer suggests that Samba File server which will be used is the latest version one which has more feature than the previous one, it is suggested that the configuration of VNC is applied on Ubuntu Linux since the service is available. Kata Kunci : Samba File Server, VNC, Ubuntu installation

Disk Storage Server

CERN Multimedia

This model was a disk storage server used in the Data Centre up until 2012. Each tray contains a hard disk drive (see the 5TB hard disk drive on the main disk display section - this actually fits into one of the trays). There are 16 trays in all per server. There are hundreds of these servers mounted on racks in the Data Centre, as can be seen.

Group-Server Queues

OpenAIRE

Li, Quan-Lin; Ma, Jing-Yu; Xie, Mingzhou; Xia, Li

2017-01-01

By analyzing energy-efficient management of data centers, this paper proposes and develops a class of interesting {\\it Group-Server Queues}, and establishes two representative group-server queues through loss networks and impatient customers, respectively. Furthermore, such two group-server queues are given model descriptions and necessary interpretation. Also, simple mathematical discussion is provided, and simulations are made to study the expected queue lengths, the expected sojourn times ...

Web server attack analyzer

OpenAIRE

Mižišin, Michal

2013-01-01

Web server attack analyzer - Abstract The goal of this work was to create prototype of analyzer of injection flaws attacks on web server. Proposed solution combines capabilities of web application firewall and web server log analyzer. Analysis is based on configurable signatures defined by regular expressions. This paper begins with summary of web attacks, followed by detection techniques analysis on web servers, description and justification of selected implementation. In the end are charact...

Nuclear waste for NT

International Nuclear Information System (INIS)

Nelson, Brendan

2005-01-01

The Northern Territory may be powerless to block the dumping of low-level nuclear waste in the Territory under legislation introduced into Parliament by Minister for Education Science and Training, Dr Brendan Nelson, in October. Despite strong opposition to the dumping of nuclear waste in the NT, the Australian Government will be able to send waste to one of the three nominated Commonwealth-owned Defence sites within the NT under the Commonwealth Radioactive Waste Management Bill 2005 and the Commonwealth Radioactive Waste Management (Related Amendment) Bill 2005. The Bills veto recently drafted NT legislation designed to scuttle the plans. Low-level nuclear waste is stored at more than 100 sites around Australia, including hospitals, factories, universities and defence facilities. Medical isotopes produced at Lucas Heights and provided for medical procedures are the source of much of this waste, including some 16 cubic metres currently held at Darwin Hospital. Dr Nelson stressed that the Government would take all die necessary steps to comply with safety and regulatory precautions, including handling waste in line with relevant environmental, nuclear safety and proliferation safeguards

Implementing Citrix XenServer Quickstarter

CERN Document Server

Ahmed, Gohar

2013-01-01

Implementing Citrix XenServer Quick Starter is a practical, hands-on guide that will help you get started with the Citrix XenServer Virtualization technology with easy-to-follow instructions.Implementing Citrix XenServer Quick Starter is for system administrators who have little to no information on virtualization and specifically Citrix XenServer Virtualization. If you're managing a lot of physical servers and are tired of installing, deploying, updating, and managing physical machines on a daily basis over and over again, then you should probably explore your option of XenServer Virtualizati

Windows PowerShell Cookbook The Complete Guide to Scripting Microsoft's New Command Shell

CERN Document Server

Holmes, Lee

2010-01-01

Do you know how to use Windows PowerShell to navigate the filesystem and manage files and folders? Or how to retrieve a web page? This introduction to the PowerShell language and scripting environment provides more than 430 task-oriented recipes to help you solve the most complex and pressing problems, and includes more than 100 tried-and-tested scripts that intermediate to advanced system administrators can copy and use immediately. You'll find hands-on tutorials on fundamentals, common tasks, and administrative jobs that you can apply whether you're on a client or server version of Windows

Server virtualization solutions

OpenAIRE

Jonasts, Gusts

2012-01-01

Currently in the information technology sector that is responsible for a server infrastructure is a huge development in the field of server virtualization on x86 computer architecture. As a prerequisite for such a virtualization development is growth in server productivity and underutilization of available computing power. Several companies in the market are working on two virtualization architectures – hypervizor and hosting. In this paper several of virtualization products that use host...

Web Server Embedded System

Directory of Open Access Journals (Sweden)

Adharul Muttaqin

2014-07-01

Full Text Available Abstrak Embedded sistem saat ini menjadi perhatian khusus pada teknologi komputer, beberapa sistem operasi linux dan web server yang beraneka ragam juga sudah dipersiapkan untuk mendukung sistem embedded, salah satu aplikasi yang dapat digunakan dalam operasi pada sistem embedded adalah web server. Pemilihan web server pada lingkungan embedded saat ini masih jarang dilakukan, oleh karena itu penelitian ini dilakukan dengan menitik beratkan pada dua buah aplikasi web server yang tergolong memiliki fitur utama yang menawarkan “keringanan” pada konsumsi CPU maupun memori seperti Light HTTPD dan Tiny HTTPD. Dengan menggunakan parameter thread (users, ramp-up periods, dan loop count pada stress test embedded system, penelitian ini menawarkan solusi web server manakah diantara Light HTTPD dan Tiny HTTPD yang memiliki kecocokan fitur dalam penggunaan embedded sistem menggunakan beagleboard ditinjau dari konsumsi CPU dan memori. Hasil penelitian menunjukkan bahwa dalam hal konsumsi CPU pada beagleboard embedded system lebih disarankan penggunaan Light HTTPD dibandingkan dengan tiny HTTPD dikarenakan terdapat perbedaan CPU load yang sangat signifikan antar kedua layanan web tersebut Kata kunci: embedded system, web server Abstract Embedded systems are currently of particular concern in computer technology, some of the linux operating system and web server variegated also prepared to support the embedded system, one of the applications that can be used in embedded systems are operating on the web server. Selection of embedded web server on the environment is still rarely done, therefore this study was conducted with a focus on two web application servers belonging to the main features that offer a "lightness" to the CPU and memory consumption as Light HTTPD and Tiny HTTPD. By using the parameters of the thread (users, ramp-up periods, and loop count on a stress test embedded systems, this study offers a solution of web server which between the Light

Development of charged particle nuclear reaction data retrieval system on IntelligentPad

International Nuclear Information System (INIS)

Ohbayashi, Yosihide; Masui, Hiroshi; Aoyama, Shigeyoshi; Kato, Kiyoshi; Chiba, Masaki

1999-01-01

An newly designed database retrieval system of charged particle nuclear reaction database system is developed with IntelligentPad architecture. We designed the network-based (server-client) data retrieval system, and a client system constructs on Windows95, 98/NT with IntelligentPad. We set the future aim of our database system toward the 'effective' use of nuclear reaction data: I. 'Re-produce, Re-edit, Re-use', II. 'Circulation, Evolution', III. 'Knowledge discovery'. Thus, further developments are under way. (author)

Professional SQL Server 2005 administration

CERN Document Server

Knight, Brian; Snyder, Wayne; Armand, Jean-Claude; LoForte, Ross; Ji, Haidong

2007-01-01

SQL Server 2005 is the largest leap forward for SQL Server since its inception. With this update comes new features that will challenge even the most experienced SQL Server DBAs. Written by a team of some of the best SQL Server experts in the industry, this comprehensive tutorial shows you how to navigate the vastly changed landscape of the SQL Server administration. Drawing on their own first-hand experiences to offer you best practices, unique tips and tricks, and useful workarounds, the authors help you handle even the most difficult SQL Server 2005 administration issues, including blockin

QlikView Server and Publisher

CERN Document Server

Redmond, Stephen

2014-01-01

This is a comprehensive guide with a step-by-step approach that enables you to host and manage servers using QlikView Server and QlikView Publisher.If you are a server administrator wanting to learn about how to deploy QlikView Server for server management,analysis and testing, and QlikView Publisher for publishing of business content then this is the perfect book for you. No prior experience with QlikView is expected.

Karst database development in Minnesota: Design and data assembly

Science.gov (United States)

Gao, Y.; Alexander, E.C.; Tipping, R.G.

2005-01-01

The Karst Feature Database (KFD) of Minnesota is a relational GIS-based Database Management System (DBMS). Previous karst feature datasets used inconsistent attributes to describe karst features in different areas of Minnesota. Existing metadata were modified and standardized to represent a comprehensive metadata for all the karst features in Minnesota. Microsoft Access 2000 and ArcView 3.2 were used to develop this working database. Existing county and sub-county karst feature datasets have been assembled into the KFD, which is capable of visualizing and analyzing the entire data set. By November 17 2002, 11,682 karst features were stored in the KFD of Minnesota. Data tables are stored in a Microsoft Access 2000 DBMS and linked to corresponding ArcView applications. The current KFD of Minnesota has been moved from a Windows NT server to a Windows 2000 Citrix server accessible to researchers and planners through networked interfaces. ?? Springer-Verlag 2005.

Ribosomal protein NtRPL17 interacts with kinesin-12 family protein NtKRP and functions in the regulation of embryo/seed size and radicle growth.

Science.gov (United States)

Tian, Shujuan; Wu, Jingjing; Liu, Yuan; Huang, Xiaorong; Li, Fen; Wang, Zhaodan; Sun, Meng-Xiang

2017-11-28

We previously reported that a novel motor protein belonging to the kinesin-12 family, NtKRP, displays critical roles in regulating embryo and seed size establishment. However, it remains unknown exactly how NtKRP contributes to this developmental process. Here, we report that a 60S ribosomal protein NtRPL17 directly interacts with NtKRP. The phenotypes of NtRPL17 RNAi lines show notable embryo and seed size reduction. Structural observations of the NtRPL17-silenced embryos/seeds reveal that the embryo size reduction is due to a decrease in cell number. In these embryos, cell division cycle progression is delayed at the G2/M transition. These phenotypes are similar to that in NtKRP-silenced embryos/seeds, indicating that NtKRP and NtRPL17 function as partners in the same regulatory pathway during seed development and specifically regulate cell cycle progression to control embryo/seed size. This work reveals that NtRPL17, as a widely distributed ribosomal protein, plays a critical role in seed development and provides a new clue in the regulation of seed size. Confirmation of the interaction between NtKRP and NtRPL17 and their co-function in the control of the cell cycle also suggests that the mechanism might be conserved in both plants and animals. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology.

PENGUKURAN KINERJA ROUND-ROBIN SCHEDULER UNTUK LINUX VIRTUAL SERVER PADA KASUS WEB SERVER

Directory of Open Access Journals (Sweden)

Royyana Muslim Ijtihadie

2005-07-01

Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Dengan meningkatnya perkembangan jumlah pengguna internet dan mulai diadopsinya penggunaan internet dalam kehidupan sehari-hari, maka lalulintas data di Internet telah meningkat secara signifikan. Sejalan dengan itu pula beban kerja server-server yang memberikan service di Internet juga mengalami kenaikan yang cukup signifikan. Hal tersebut dapat mengakibatkan suatu server mengalami kelebihan beban pada suatu saat. Untuk mengatasi hal tersebut maka diterapkan skema konfigurasi server cluster menggunakan konsep load balancing. Load balancing server menerapkan algoritma dalam melakukan pembagian tugas. Algoritma round robin telah digunakan pada Linux Virtual Server. Penelitian ini melakukan pengukuran kinerja terhadap Linux Virtual Server yang menggunakan algoritma round robin untuk melakukan penjadwalan pembagian beban terhadap server. Penelitian ini mengukur performa dari sisi client yang mencoba mengakses web server.performa yang diukur adalah jumlah request yang bisa diselesaikan perdetik (request per second, waktu untuk menyelesaikan per satu request, dan   throughput yang dihasilkan. Dari hasil percobaan didapatkan bahwa penggunaan LVS bisa meningkatkan performa, yaitu menaikkan jumlah request per detik

SPSS 9.0 for Windows 98/NT统计软件包简介

Institute of Scientific and Technical Information of China (English)

李志辉; 洪楠

2000-01-01

@@ SPSS(Statistical Package for the Social Science)是由美国SPSS公司自80年代初开发的大型统计学软件包.1998年推出的SPSS 9.0版本,除保持了以往SPSS的诸多优点以外,还汇集了SAS for Windows[1,2]与STATISTICA for Windows95/NT[3,4]的长处,是当今世界上最新、最流行、最受欢迎的统计软件包之一.与SPSS 7.5比较,SPSS 9.0具有以下新的特点[5].

Mastering Microsoft Exchange Server 2010

CERN Document Server

McBee, Jim

2010-01-01

A top-selling guide to Exchange Server-now fully updated for Exchange Server 2010. Keep your Microsoft messaging system up to date and protected with the very newest version, Exchange Server 2010, and this comprehensive guide. Whether you're upgrading from Exchange Server 2007 SP1 or earlier, installing for the first time, or migrating from another system, this step-by-step guide provides the hands-on instruction, practical application, and real-world advice you need.: Explains Microsoft Exchange Server 2010, the latest release of Microsoft's messaging system that protects against spam and vir

Optimal control of a server farm

NARCIS (Netherlands)

Adan, I.J.B.F.; Kulkarni, V.G.; Wijk, van A.C.C.

2013-01-01

We consider a server farm consisting of ample exponential servers, that serve a Poisson stream of arriving customers. Each server can be either busy, idle or off. An arriving customer will immediately occupy an idle server, if there is one, and otherwise, an off server will be turned on and start

NEOS Server 4.0 Administrative Guide

OpenAIRE

Dolan, Elizabeth D.

2001-01-01

The NEOS Server 4.0 provides a general Internet-based client/server as a link between users and software applications. The administrative guide covers the fundamental principals behind the operation of the NEOS Server, installation and trouble-shooting of the Server software, and implementation details of potential interest to a NEOS Server administrator. The guide also discusses making new software applications available through the Server, including areas of concern to remote solver adminis...

Analyzing the Effect of TCP and Server Population on Massively Multiplayer Games

Directory of Open Access Journals (Sweden)

Mirko Suznjevic

2014-01-01

Full Text Available Many Massively Multiplayer Online Role-Playing Games (MMORPGs use TCP flows for communication between the server and the game clients. The utilization of TCP, which was not initially designed for (soft real-time services, has many implications for the competing traffic flows. In this paper we present a series of studies which explore the competition between MMORPG and other traffic flows. For that aim, we first extend a source-based traffic model, based on player’s activities during the day, to also incorporate the impact of the number of players sharing a server (server population on network traffic. Based on real traffic traces, we statistically model the influence of the variation of the server’s player population on the network traffic, depending on the action categories (i.e., types of in-game player behaviour. Using the developed traffic model we prove that while server population only modifies specific action categories, this effect is significant enough to be observed on the overall traffic. We find that TCP Vegas is a good option for competing flows in order not to throttle the MMORPG flows and that TCP SACK is more respectful with game flows than other TCP variants, namely, Tahoe, Reno, and New Reno. Other tests show that MMORPG flows do not significantly reduce their sending window size when competing against UDP flows. Additionally, we study the effect of RTT unfairness between MMORPG flows, showing that it is less important than in the case of network-limited TCP flows.

Microsoft SQL Server 2012 bible

CERN Document Server

Jorgensen, Adam; LeBlanc, Patrick; Cherry, Denny; Nelson, Aaron

2012-01-01

Harness the powerful new SQL Server 2012 Microsoft SQL Server 2012 is the most significant update to this product since 2005, and it may change how database administrators and developers perform many aspects of their jobs. If you're a database administrator or developer, Microsoft SQL Server 2012 Bible teaches you everything you need to take full advantage of this major release. This detailed guide not only covers all the new features of SQL Server 2012, it also shows you step by step how to develop top-notch SQL Server databases and new data connections and keep your databases performing at p

BNFL Magnox - Upgrades and enhancements

International Nuclear Information System (INIS)

Udbinac, M.J.

2006-01-01

In the past, generic models, restrictive budgets,and general shortages of resources have limited the scope of the UK's older Magnox simulators. Nevertheless, the simulators evolved slowly over time, becoming more like their reference plants, as resources became available. Three years ago, the Training and Development Branch of Magnox Electric plc took a giant leap, investing significant resources into the modernization of their training simulators. New hardware was built, including a new simulator room. The simulator software was ported from Unix running on outdated servers to new servers running Microsoft Windows NT. Perhaps most significantly, major model enhancements were made to key plant systems to significantly increase the likeness of each simulator to its reference plant. The upgrade to NT, the addition of state-of-the-art instructor stations, and some of the model enhancements were achieved with SimPort, an all-inclusive simulation package provided by DS and S. This paper will provide a more detailed view of the Magnox modular simulators, including how they are used and how they have benefited from the enhancements and upgrades implemented during the project. (author)

NT-proBNP

DEFF Research Database (Denmark)

Andersen, Charlotte; Mellemkjær, Søren; Hilberg, Ole

2016-01-01

BACKGROUND: Pulmonary hypertension (PH) is a serious complication to interstitial lung disease (ILD) and has a poor prognosis. PH is often diagnosed by screening with echocardiography followed by right heart catheterisation. A previous study has shown that a value of NT-pro-brain natriuretic...

Linux Server Security

CERN Document Server

Bauer, Michael D

2005-01-01

Linux consistently appears high up in the list of popular Internet servers, whether it's for the Web, anonymous FTP, or general services such as DNS and delivering mail. But security is the foremost concern of anyone providing such a service. Any server experiences casual probe attempts dozens of time a day, and serious break-in attempts with some frequency as well. This highly regarded book, originally titled Building Secure Servers with Linux, combines practical advice with a firm knowledge of the technical tools needed to ensure security. The book focuses on the most common use of Linux--

NT-proBNP concentrations in mountain marathoners.

Science.gov (United States)

Banfi, Giuseppe; Lippi, Giuseppe; Susta, Daniele; Barassi, Alessandra; D'Eril, Gianvico Melzi; Dogliotti, Giada; Corsi, Massimiliano M

2010-05-01

The 76 amino acid N-terminal proB-type natriuretic peptide (NT-proBNP) is proposed for evaluating and monitoring heart pathologies characterized by myocardial wall stress. Strenuous exercise might generate transitory ischemia, myocardial stress, and diastolic left ventricular dysfunction, possibly inducing an increase of some biochemical parameter concentrations. An alert has been claimed owing to biochemical and instrumental signs of heart dysfunction in recreational athletes during marathon races. We studied the behaviour of NT-proBNP in 15 mountain marathoners before and after a race. The concentrations of the parameter were lower than that observed in controls at rest and were similar to that observed in professional soccer and rugby players. The concentrations significantly increased after the race. NT-proBNP is low at rest in professional athletes, and the increase after physical exercise is physiological. The marathoners, even when performing races in a high-altitude environment, show NT-proBNP concentrations similar to those of athletes from other sports disciplines, characterized by low levels of effort and by a mix of aerobic and anaerobic metabolism. The increase of NT-proBNP is linked to strenuous physical exercise and to heavy heart effort, testified also by an increase of troponin I. However, the role of the NT-proBNP could be important to screen recreational and professional marathoners to avoid possible heart problems and sudden cardiac death in subjects with occult heart disease. The results of the present study are relevant to the design and evaluation of training programs for improving strength and function of professional marathoners.

Learning SQL Server Reporting Services 2012

CERN Document Server

Krishnaswamy, Jayaram

2013-01-01

The book is packed with clear instructions and plenty of screenshots, providing all the support and guidance you will need as you begin to generate reports with SQL Server 2012 Reporting Services.This book is for those who are new to SQL Server Reporting Services 2012 and aspiring to create and deploy cutting edge reports. This book is for report developers, report authors, ad-hoc report authors and model developers, and Report Server and SharePoint Server Integrated Report Server administrators. Minimal knowledge of SQL Server is assumed and SharePoint experience would be helpful.

The Development of On-Line Statistics Program for Radiation Oncology

International Nuclear Information System (INIS)

Kim, Yoon Jong; Lee, Dong Hoon; Ji, Young Hoon; Lee, Dong Han; Jo, Chul Ku; Kim, Mi Sook; Ru, Sung Rul; Hong, Seung Hong

2001-01-01

Purpose : By developing on-line statistics program to record the information of radiation oncology to share the information with internet. It is possible to supply basic reference data for administrative plans to improve radiation oncology. Materials and methods : The information of radiation oncology statistics had been collected by paper forms about 52 hospitals in the past. Now, we can input the data by internet web browsers. The statistics program used windows NT 4.0 operation system, Internet Information Server 4.0 (IIS4.0) as a web server and the Microsoft Access MDB. We used Structured Query Language (SQL), Visual Basic, VBScript and JAVAScript to display the statistics according to years and hospitals. Results : This program shows present conditions about man power, research, therapy machines, technic, brachytherapy, clinic statistics, radiation safety management, institution, quality assurance and radioisotopes in radiation oncology department. The database consists of 38 inputs and 6 outputs windows. Statistical output windows can be increased continuously according to user need. Conclusion : We have developed statistics program to process all of the data in department of radiation oncology for reference information. Users easily could input the data by internet web browsers and share the information

Beginning Microsoft SQL Server 2012 Programming

CERN Document Server

Atkinson, Paul

2012-01-01

Get up to speed on the extensive changes to the newest release of Microsoft SQL Server The 2012 release of Microsoft SQL Server changes how you develop applications for SQL Server. With this comprehensive resource, SQL Server authority Robert Vieira presents the fundamentals of database design and SQL concepts, and then shows you how to apply these concepts using the updated SQL Server. Publishing time and date with the 2012 release, Beginning Microsoft SQL Server 2012 Programming begins with a quick overview of database design basics and the SQL query language and then quickly proceeds to sho

Sincronización de Células de Tabaco (Nicotiana tabacum) NT-1 Synchronization of tobacco cells (Nicotiana tabacum) NT-1

OpenAIRE

León F Ruiz; Ana E Higareda; Marco A Pardo

2010-01-01

Se ha evaluado la capacidad sincronizante de afidicolina e hidroxiurea en cultivos de células de tabaco (Nicotiana tabacum) NT-1. Los cultivos sincronizados son poderosas herramientas en estudios moleculares y bioquímicos relacionados al ciclo celular y comúnmente se utilizan químicos para bloquear el ciclo celular. La línea celular de tabaco (Nicotiana tabacum) NT-1 proviene de la línea celular TBY-2, caracterizándose NT-1 por su menor velocidad de crecimiento y tamaño celular heterogéneo. L...

SPEER-SERVER: a web server for prediction of protein specificity determining sites.

Science.gov (United States)

Chakraborty, Abhijit; Mandloi, Sapan; Lanczycki, Christopher J; Panchenko, Anna R; Chakrabarti, Saikat

2012-07-01

Sites that show specific conservation patterns within subsets of proteins in a protein family are likely to be involved in the development of functional specificity. These sites, generally termed specificity determining sites (SDS), might play a crucial role in binding to a specific substrate or proteins. Identification of SDS through experimental techniques is a slow, difficult and tedious job. Hence, it is very important to develop efficient computational methods that can more expediently identify SDS. Herein, we present Specificity prediction using amino acids' Properties, Entropy and Evolution Rate (SPEER)-SERVER, a web server that predicts SDS by analyzing quantitative measures of the conservation patterns of protein sites based on their physico-chemical properties and the heterogeneity of evolutionary changes between and within the protein subfamilies. This web server provides an improved representation of results, adds useful input and output options and integrates a wide range of analysis and data visualization tools when compared with the original standalone version of the SPEER algorithm. Extensive benchmarking finds that SPEER-SERVER exhibits sensitivity and precision performance that, on average, meets or exceeds that of other currently available methods. SPEER-SERVER is available at http://www.hpppi.iicb.res.in/ss/.

Web GIS in practice IV: publishing your health maps and connecting to remote WMS sources using the Open Source UMN MapServer and DM Solutions MapLab

Directory of Open Access Journals (Sweden)

Honda Kiyoshi

2006-01-01

Full Text Available Abstract Open Source Web GIS software systems have reached a stage of maturity, sophistication, robustness and stability, and usability and user friendliness rivalling that of commercial, proprietary GIS and Web GIS server products. The Open Source Web GIS community is also actively embracing OGC (Open Geospatial Consortium standards, including WMS (Web Map Service. WMS enables the creation of Web maps that have layers coming from multiple different remote servers/sources. In this article we present one easy to implement Web GIS server solution that is based on the Open Source University of Minnesota (UMN MapServer. By following the accompanying step-by-step tutorial instructions, interested readers running mainstream Microsoft® Windows machines and with no prior technical experience in Web GIS or Internet map servers will be able to publish their own health maps on the Web and add to those maps additional layers retrieved from remote WMS servers. The 'digital Asia' and 2004 Indian Ocean tsunami experiences in using free Open Source Web GIS software are also briefly described.

Remote Sensing Data Analytics for Planetary Science with PlanetServer/EarthServer

Science.gov (United States)

Rossi, Angelo Pio; Figuera, Ramiro Marco; Flahaut, Jessica; Martinot, Melissa; Misev, Dimitar; Baumann, Peter; Pham Huu, Bang; Besse, Sebastien

2016-04-01

Planetary Science datasets, beyond the change in the last two decades from physical volumes to internet-accessible archives, still face the problem of large-scale processing and analytics (e.g. Rossi et al., 2014, Gaddis and Hare, 2015). PlanetServer, the Planetary Science Data Service of the EC-funded EarthServer-2 project (#654367) tackles the planetary Big Data analytics problem with an array database approach (Baumann et al., 2014). It is developed to serve a large amount of calibrated, map-projected planetary data online, mainly through Open Geospatial Consortium (OGC) Web Coverage Processing Service (WCPS) (e.g. Rossi et al., 2014; Oosthoek et al., 2013; Cantini et al., 2014). The focus of the H2020 evolution of PlanetServer is still on complex multidimensional data, particularly hyperspectral imaging and topographic cubes and imagery. In addition to hyperspectral and topographic from Mars (Rossi et al., 2014), the use of WCPS is applied to diverse datasets on the Moon, as well as Mercury. Other Solar System Bodies are going to be progressively available. Derived parameters such as summary products and indices can be produced through WCPS queries, as well as derived imagery colour combination products, dynamically generated and accessed also through OGC Web Coverage Service (WCS). Scientific questions translated into queries can be posed to a large number of individual coverages (data products), locally, regionally or globally. The new PlanetServer system uses the the Open Source Nasa WorldWind (e.g. Hogan, 2011) virtual globe as visualisation engine, and the array database Rasdaman Community Edition as core server component. Analytical tools and client components of relevance for multiple communities and disciplines are shared across service such as the Earth Observation and Marine Data Services of EarthServer. The Planetary Science Data Service of EarthServer is accessible on http://planetserver.eu. All its code base is going to be available on GitHub, on

Learning Zimbra Server essentials

CERN Document Server

Kouka, Abdelmonam

2013-01-01

A standard tutorial approach which will guide the readers on all of the intricacies of the Zimbra Server.If you are any kind of Zimbra user, this book will be useful for you, from newbies to experts who would like to learn how to setup a Zimbra server. If you are an IT administrator or consultant who is exploring the idea of adopting, or have already adopted Zimbra as your mail server, then this book is for you. No prior knowledge of Zimbra is required.

Understanding Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

GeoServer: il server geospaziale Open Source novità della nuova versione 2.3.0

Directory of Open Access Journals (Sweden)

Simone Giannecchini

2013-04-01

Full Text Available GeoServer è un server geospaziale Open Source sviluppato con tecnologia Java Enterprise per la gestione e l’editing di dati geospaziali secondo gli standard OGC e ISO Technical Committee 211. Esso fornisce le funzionalità di base per creareinfrastrutture spaziali di dati (SDI ed è progettato per essere interoperabile potendo pubblicare dati provenienti da ogni tipo di fonte spaziale utilizzando standard aperti.Open Source GeoSpatial server developed with Java Enterprise technology for managing, sharing and editing geospatial data according to the OGC and ISO TC 211 standards. GeoServer provides the basic functionalities to create spatial data infrastructures (SDI.GeoServer is designed for interoperability, it publishes data from any major spatial data source using open standards: it is the reference implementation of the Open Geospatial Consortium (OGC Web Feature Service (WFS and Web Coverage Service (WCS standards, as well as a highperformance certified compliant Web Map Service (WMS. GeoServer forms a core component of the Geospatial Web.

Differential ontogenetic patterns of levocabastine-sensitive neurotensin NT2 receptors and of NT1 receptors in the rat brain revealed by in situ hybridization.

Science.gov (United States)

Lépée-Lorgeoux, I; Betancur, C; Rostène, W; Pélaprat, D

1999-03-12

The postnatal ontogeny of the levocabastine-sensitive neurotensin receptor (NT2) mRNA was studied by in situ hybridization in the rat brain and compared with the distribution of the levocabastine-insensitive NT1 receptor. NT2 receptor mRNA was absent at birth from all brain structures except the ependymal cell layer lining the ventricles. The development of NT2 receptor mRNA followed three ontogenetic patterns. The first pattern, involving the majority of the cerebral gray matter, was characterized by a continuous increase from postnatal day 5 (P5) to P30. The second one, involving regions rich in myelinated fibers such as the corpus callosum and lacunosum moleculare layer of the hippocampus, exhibited a pronounced increase between P5 and P10, peaked at P15 and was followed by a plateau or a slight decrease. The third pattern was observed in the ependymal cell layer lining the olfactory and lateral ventricles, where the high labeling already present at birth continued to increase during development. These different developmental patterns could reflect the variety of cells expressing NT2 receptor mRNA, including neurons, protoplasmic astrocytes in gray matter, fibrous astrocytes present in myelinated fibers tracts, and ependymal cells. In contrast, NT1 receptor mRNA, which seems to be associated only with neurons, was highly and transiently expressed during the perinatal period in the cerebral cortex, hippocampus and striatal neuroepithelium. Other regions, notably the ventral tegmental area and substantia nigra compacta, exhibited a gradual increase in NT1 receptor signal, reaching adult levels by P21. Both the differential localization and ontogenetic profiles of NT1 and NT2 receptor mRNAs suggest different involvement of these two receptors in brain functions and development. Copyright 1999 Elsevier Science B.V.

Professional Microsoft SQL Server 2012 Administration

CERN Document Server

Jorgensen, Adam; LoForte, Ross; Knight, Brian

2012-01-01

An essential how-to guide for experienced DBAs on the most significant product release since 2005! Microsoft SQL Server 2012 will have major changes throughout the SQL Server and will impact how DBAs administer the database. With this book, a team of well-known SQL Server experts introduces the many new features of the most recent version of SQL Server and deciphers how these changes will affect the methods that administrators have been using for years. Loaded with unique tips, tricks, and workarounds for handling the most difficult SQL Server admin issues, this how-to guide deciphers topics s

Extension of the DIRAC workload management system to allow use of distributed windows resources

International Nuclear Information System (INIS)

Li, Y Y; Harrison, K; Parker, M A; Lyutsarev, V; Tsaregorodtsev, A

2008-01-01

The DIRAC Workload Management System of the LHCb experiment allows coordinated use of globally distributed computing power and data storage. The system was initially deployed on the Linux platforms, where it has been used very successfully both for collaboration-wide production activities and for single-user physics studies. To increase the resources available to LHCb, DIRAC has been extended so that it also allows use of Microsoft Windows machines. As DIRAC is mostly written in Python, a large part of the code base was already platform independent, but Windows-specific solutions have had to be found in areas such as certificate-based authentication and secure file transfers, where .NetGridFTP has been used. In addition, new code has been written to deal with the way that jobs are run and monitored under Windows, enabling interaction with Microsoft Windows Compute Cluster Server 2003 on sets of machines were this is available. The result is a system that allows users transparent access to Linux and Windows distributed resources. This paper gives details of the Windows-specific developments for DIRAC; outlines the experience gained in deploying the system at a number of sites, and reports on the performance achieved running the LHCb data-processing applications

Linear flow dynamics near a T/NT interface

Science.gov (United States)

Teixeira, Miguel; Silva, Carlos

2011-11-01

The characteristics of a suddenly-inserted T/NT interface separating a homogeneous and isotropic shear-free turbulence region from a non-turbulent flow region are investigated using rapid distortion theory (RDT), taking full account of viscous effects. Profiles of the velocity variances, TKE, viscous dissipation rate, turbulence length scales, and pressure statistics are derived, showing very good agreement with DNS. The normalized inviscid flow statistics at the T/NT interface do not depend on the form of the assumed TKE spectrum. In the non-turbulent region, where the flow is irrotational (except within a thin viscous boundary layer), the dissipation rate decays as z-6, where z is distance from the T/NT interface. The mean pressure exhibits a decrease towards the turbulence due to the associated velocity fluctuations, consistent with the generation of a mean entrainment velocity. The vorticity variance and dissipation rate display large maxima at the T/NT interface due to the existing inviscid discontinuities of the tangential velocity, and these maxima are quantitatively related to the thickness of the viscous boundary layer (VBL). At equilibrium, RDT suggests that the thickness of the T/NT interface scales on the Kolmogorov microscale. We acknowledge the financial support of FCT under Project PTDC/EME-MFE/099636/2008.

Essential Mac OS X panther server administration integrating Mac OS X server into heterogeneous networks

CERN Document Server

Bartosh, Michael

2004-01-01

If you've ever wondered how to safely manipulate Mac OS X Panther Server's many underlying configuration files or needed to explain AFP permission mapping--this book's for you. From the command line to Apple's graphical tools, the book provides insight into this powerful server software. Topics covered include installation, deployment, server management, web application services, data gathering, and more

Best management practices and work plan for installation of and monitoring at temporary weirs and flumes at NT-3, NT-4, and NT-5 Oak Ridge Y-12 Plant, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1998-02-01

This Best Management Practices (BMP) and Work Plan has been developed in order to maintain compliance with applicable regulatory requirements by documenting the practices that are required during the installation and maintenance of temporary weirs and flumes at the NT-3, NT-4, and NT-5 tributaries, subsequent collection of water discharge data, and removal of the weirs and flumes. The practices included in this BMP comply with the Clean Water Act and the intent of Sect. 70-8-104(b) of the Tennessee Code Annotated: Tennessee Wildlife Resources Commission Proclamation 94-16 to prevent the destruction of the habitat of state-listed wildlife species that are designated as open-quotes in need of management.close quotes

Network characteristics for server selection in online games

Science.gov (United States)

Claypool, Mark

2008-01-01

Online gameplay is impacted by the network characteristics of players connected to the same server. Unfortunately, the network characteristics of online game servers are not well-understood, particularly for groups that wish to play together on the same server. As a step towards a remedy, this paper presents analysis of an extensive set of measurements of game servers on the Internet. Over the course of many months, actual Internet game servers were queried simultaneously by twenty-five emulated game clients, with both servers and clients spread out on the Internet. The data provides statistics on the uptime and populations of game servers over a month long period an an in-depth look at the suitability for game servers for multi-player server selection, concentrating on characteristics critical to playability--latency and fairness. Analysis finds most game servers have latencies suitable for third-person and omnipresent games, such as real-time strategy, sports and role-playing games, providing numerous server choices for game players. However, far fewer game servers have the low latencies required for first-person games, such as shooters or race games. In all cases, groups that wish to play together have a greatly reduced set of servers from which to choose because of inherent unfairness in server latencies and server selection is particularly limited as the group size increases. These results hold across different game types and even across different generations of games. The data should be useful for game developers and network researchers that seek to improve game server selection, whether for single or multiple players.

A Capacity Supply Model for Virtualized Servers

Directory of Open Access Journals (Sweden)

Alexander PINNOW

2009-01-01

Full Text Available This paper deals with determining the capacity supply for virtualized servers. First, a server is modeled as a queue based on a Markov chain. Then, the effect of server virtualization on the capacity supply will be analyzed with the distribution function of the server load.

Development of network based control and data acquisition systems for diagnostics using CCD detectors. Application to LHD experiments

International Nuclear Information System (INIS)

Kado, Shinichiro; Nakanishi, Hideya; Ida, Katsumi; Kojima, Mamoru

2000-01-01

The needs of CCD detectors as a plasma diagnostic tool have recently been increased. However, many CCD providers have developed their own controlling systems, and it is difficult to customized the usages in order to make them applicable to the network-based data acquisition clusters which consist of various sorts of diagnostics. This paper presents the development of systems in which CCD detectors are controlled and the data are acquired through networks. By making use of the Client/Server (C/S) model in the Windows NT operating system and block transfer method via shared memory relevant to the model, the dependence on the hardware is hidden by the server service, CCD list sequencer. The client program is designed for the LHD (Large Helical Device) discharge operation sequences and the data acquisition system. (author)

Server for experimental data from LHD

International Nuclear Information System (INIS)

Emoto, M.; Ohdachi, S.; Watanabe, K.; Sudo, S.; Nagayama, Y.

2006-01-01

In order to unify various types of data, the Kaiseki Server was developed. This server provides physical experimental data of large helical device (LHD) experiments. Many types of data acquisition systems currently exist in operation, and they produce files of various formats. Therefore, it has been difficult to analyze different types of acquisition data at the same time because the data of each system should be read in a particular manner. To facilitate the usage of this data by researchers, the authors have developed a new server system, which provides a unified data format and a unique data retrieval interface. Although the Kaiseki Server satisfied the initial demand, new requests arose from researchers, one of which was the remote usage of the server. The current system cannot be used remotely because of security issues. Another request was group ownership, i.e., users belonging to the same group should have equal access to data. To satisfy these demands, the authors modified the server. However, since other requests may arise in the future, the new system must be flexible so that it can satisfy future demands. Therefore, the authors decided to develop a new server using a three-tier structure

NRSAS: Nuclear Receptor Structure Analysis Servers.

NARCIS (Netherlands)

Bettler, E.J.M.; Krause, R.; Horn, F.; Vriend, G.

2003-01-01

We present a coherent series of servers that can perform a large number of structure analyses on nuclear hormone receptors. These servers are part of the NucleaRDB project, which provides a powerful information system for nuclear hormone receptors. The computations performed by the servers include

Window Glazing Types | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Window Frame Types | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Window Operator Types | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Particulated articular cartilage: CAIS and DeNovo NT.

Science.gov (United States)

Farr, Jack; Cole, Brian J; Sherman, Seth; Karas, Vasili

2012-03-01

Cartilage Autograft Implantation System (CAIS; DePuy/Mitek, Raynham, MA) and DeNovo Natural Tissue (NT; ISTO, St. Louis, MO) are novel treatment options for focal articular cartilage defects in the knee. These methods involve the implantation of particulated articular cartilage from either autograft or juvenile allograft donor, respectively. In the laboratory and in animal models, both CAIS and DeNovo NT have demonstrated the ability of the transplanted cartilage cells to "escape" from the extracellular matrix, migrate, multiply, and form a new hyaline-like cartilage tissue matrix that integrates with the surrounding host tissue. In clinical practice, the technique for both CAIS and DeNovo NT is straightforward, requiring only a single surgery to affect cartilage repair. Clinical experience is limited, with short-term studies demonstrating both procedures to be safe, feasible, and effective, with improvements in subjective patient scores, and with magnetic resonance imaging evidence of good defect fill. While these treatment options appear promising, prospective randomized controlled studies are necessary to refine the indications and contraindications for both CAIS and DeNovo NT.

National Medical Terminology Server in Korea

Science.gov (United States)

Lee, Sungin; Song, Seung-Jae; Koh, Soonjeong; Lee, Soo Kyoung; Kim, Hong-Gee

Interoperable EHR (Electronic Health Record) necessitates at least the use of standardized medical terminologies. This paper describes a medical terminology server, LexCare Suite, which houses terminology management applications, such as a terminology editor, and a terminology repository populated with international standard terminology systems such as Systematized Nomenclature of Medicine (SNOMED). The server is to satisfy the needs of quality terminology systems to local primary to tertiary hospitals. Our partner general hospitals have used the server to test its applicability. This paper describes the server and the results of the applicability test.

A CoGeNT confirmation of the DAMA signal

International Nuclear Information System (INIS)

Foot, R.

2010-01-01

The CoGeNT Collaboration has recently reported a rising low energy spectrum in their ultra low noise Germanium detector. This is particularly interesting as the energy range probed by CoGeNT overlaps with the energy region in which DAMA has observed their annual modulation signal. We show that the mirror dark matter candidate can simultaneously explain both the DAMA annual modulation signal and the rising low energy spectrum observed by CoGeNT. This constitutes a model dependent confirmation of the DAMA signal and adds weight to the mirror dark matter paradigm.

Development of safeguards information treatment system at facility level in Korea

International Nuclear Information System (INIS)

So, D.S.; Lee, B.D.; Song, D.Y.

2001-01-01

Safeguards Information Treatment System (SITS) at Facility level was developed to implement efficiently the obligations under IAEA comprehensive Safeguards Agreement, bilateral nuclear cooperation Agreements with other countries and domestic law, and to manage efficiently the information related to safeguards implementation at facility level in Korea. Nuclear facilities in Korea are categorized into 8 types based on its accounting characteristics as follows: (1) Item counting facility or bulk handling facility; (2) Batch follow-up facility or not; (3) MUF (Material Unaccounted For) occurrence or not; (4) Nuclear production facility or not; (5) Operation status of facility; (6) Information management of nuclear material transfer status between KMPs or not; (7) Indication of inventory KMP on the inventory change of nuclear material is required or not. Hardware and Software for SITS can be loaded on a personal computer under operation system of Window 2000 or Window NT. MS SQL server 7 and MS Internet Information Server were adopted for database management system and Web server, respectively. Network environment of SITS was designed to include nuclear research institute, nuclear power plants of PWR and CANDU, nuclear fuel fabrication facilities and other facilities. SITS can be operated standalone or under the client-server system if intranet exists. More detailed contents of SITS are described elsewhere. Each module of SITS will be tested during incorporation of existing data into SITS and SITS will be distributed to nuclear facilities in Korea

NExT server

CERN Document Server

1989-01-01

The first website at CERN - and in the world - was dedicated to the World Wide Web project itself and was hosted on Berners-Lee's NeXT computer. The website described the basic features of the web; how to access other people's documents and how to set up your own server. This NeXT machine - the original web server - is still at CERN. As part of the project to restore the first website, in 2013 CERN reinstated the world's first website to its original address.

CORAL Server and CORAL Server Proxy: Scalable Access to Relational Databases from CORAL Applications

CERN Document Server

Valassi, A; Kalkhof, A; Salnikov, A; Wache, M

2011-01-01

The CORAL software is widely used at CERN for accessing the data stored by the LHC experiments using relational database technologies. CORAL provides a C++ abstraction layer that supports data persistency for several backends and deployment models, including local access to SQLite files, direct client access to Oracle and MySQL servers, and read-only access to Oracle through the FroNTier web server and cache. Two new components have recently been added to CORAL to implement a model involving a middle tier "CORAL server" deployed close to the database and a tree of "CORAL server proxy" instances, with data caching and multiplexing functionalities, deployed close to the client. The new components are meant to provide advantages for read-only and read-write data access, in both offline and online use cases, in the areas of scalability and performance (multiplexing for several incoming connections, optional data caching) and security (authentication via proxy certificates). A first implementation of the two new c...

Rise and fall of NT-proBNP in aortic valve intervention.

Science.gov (United States)

Hultkvist, Henrik; Holm, Jonas; Svedjeholm, Rolf; Vánky, Farkas

2018-01-01

To describe the dynamics of N-terminal pro-B-type natriuretic peptide (NT-proBNP) from preoperative evaluation to 6-month follow-up in patients undergoing aortic valve intervention, and to evaluate NT-proBNP with regard to 1-year mortality. At preoperative evaluation, we prospectively included 462 patients accepted for aortic valve intervention. The median time to surgical aortic valve replacement (SAVR; n=336) or transcatheter aortic valve implantation (TAVI; n=126) was 4 months. NT-proBNP was measured at enrolment for preoperative evaluation, on the day of surgery, postoperatively on day 1, day 3 and at the 6-month follow-up. Subgroups of patients undergoing SAVR with aortic regurgitation and aortic stenosis with and without coronary artery bypass were also analysed. NT-proBNP remained stable in all subgroups during the preoperative waiting period, but displayed a substantial transient early postoperative increase with a peak on day 3 except in the TAVI group, which peaked on day 1. At the 6-month follow-up, NT-proBNP had decreased to or below the preoperative level in all groups. In the SAVR group, NT-proBNP preoperatively and on postoperative days 1 and 3 revealed significant discriminatory power with regard to 1-year mortality (area under the curve (AUC)=0.79, P=0.0001; AUC=0.71, P=0.03; and AUC=0.79, P=0.002, respectively). This was not found in the TAVI group, which had higher levels of NT-proBNP both preoperatively and at the 6-month follow-up compared with the SAVR group. The dynamic profile of NT-proBNP differed between patients undergoing TAVI and SAVR. NT-proBNP in the perioperative course was associated with increased risk of 1-year mortality in SAVR but not in TAVI.

Personalized Pseudonyms for Servers in the Cloud

Directory of Open Access Journals (Sweden)

Xiao Qiuyu

2017-10-01

Full Text Available A considerable and growing fraction of servers, especially of web servers, is hosted in compute clouds. In this paper we opportunistically leverage this trend to improve privacy of clients from network attackers residing between the clients and the cloud: We design a system that can be deployed by the cloud operator to prevent a network adversary from determining which of the cloud’s tenant servers a client is accessing. The core innovation in our design is a PoPSiCl (pronounced “popsicle”, a persistent pseudonym for a tenant server that can be used by a single client to access the server, whose real identity is protected by the cloud from both passive and active network attackers. When instantiated for TLS-based access to web servers, our design works with all major browsers and requires no additional client-side software and minimal changes to the client user experience. Moreover, changes to tenant servers can be hidden in supporting software (operating systems and web-programming frameworks without imposing on web-content development. Perhaps most notably, our system boosts privacy with minimal impact to web-browsing performance, after some initial setup during a user’s first access to each web server.

WeBIAS: a web server for publishing bioinformatics applications.

Science.gov (United States)

Daniluk, Paweł; Wilczyński, Bartek; Lesyng, Bogdan

2015-11-02

One of the requirements for a successful scientific tool is its availability. Developing a functional web service, however, is usually considered a mundane and ungratifying task, and quite often neglected. When publishing bioinformatic applications, such attitude puts additional burden on the reviewers who have to cope with poorly designed interfaces in order to assess quality of presented methods, as well as impairs actual usefulness to the scientific community at large. In this note we present WeBIAS-a simple, self-contained solution to make command-line programs accessible through web forms. It comprises a web portal capable of serving several applications and backend schedulers which carry out computations. The server handles user registration and authentication, stores queries and results, and provides a convenient administrator interface. WeBIAS is implemented in Python and available under GNU Affero General Public License. It has been developed and tested on GNU/Linux compatible platforms covering a vast majority of operational WWW servers. Since it is written in pure Python, it should be easy to deploy also on all other platforms supporting Python (e.g. Windows, Mac OS X). Documentation and source code, as well as a demonstration site are available at http://bioinfo.imdik.pan.pl/webias . WeBIAS has been designed specifically with ease of installation and deployment of services in mind. Setting up a simple application requires minimal effort, yet it is possible to create visually appealing, feature-rich interfaces for query submission and presentation of results.

An adversarial queueing model for online server routing

NARCIS (Netherlands)

Bonifaci, V.

2007-01-01

In an online server routing problem, a vehicle or server moves in a network in order to process incoming requests at the nodes. Online server routing problems have been thoroughly studied using competitive analysis. We propose a new model for online server routing, based on adversarial queueing

Changes in Air CO2 Concentration Differentially Alter Transcript Levels of NtAQP1 and NtPIP2;1 Aquaporin Genes in Tobacco Leaves

Directory of Open Access Journals (Sweden)

Francesca Secchi

2016-04-01

Full Text Available The aquaporin specific control on water versus carbon pathways in leaves is pivotal in controlling gas exchange and leaf hydraulics. We investigated whether Nicotiana tabacum aquaporin 1 (NtAQP1 and Nicotiana tabacum plasma membrane intrinsic protein 2;1 (NtPIP2;1 gene expression varies in tobacco leaves subjected to treatments with different CO2 concentrations (ranging from 0 to 800 ppm, inducing changes in photosynthesis, stomatal regulation and water evaporation from the leaf. Changes in air CO2 concentration ([CO2] affected net photosynthesis (Pn and leaf substomatal [CO2] (Ci. Pn was slightly negative at 0 ppm air CO2; it was one-third that of ambient controls at 200 ppm, and not different from controls at 800 ppm. Leaves fed with 800 ppm [CO2] showed one-third reduced stomatal conductance (gs and transpiration (E, and their gs was in turn slightly lower than in 200 ppm– and in 0 ppm–treated leaves. The 800 ppm air [CO2] strongly impaired both NtAQP1 and NtPIP2;1 gene expression, whereas 0 ppm air [CO2], a concentration below any in vivo possible conditions and specifically chosen to maximize the gene expression alteration, increased only the NtAQP1 transcript level. We propose that NtAQP1 expression, an aquaporin devoted to CO2 transport, positively responds to CO2 scarcity in the air in the whole range 0–800 ppm. On the contrary, expression of NtPIP2;1, an aquaporin not devoted to CO2 transport, is related to water balance in the leaf, and changes in parallel with gs. These observations fit in a model where upregulation of leaf aquaporins is activated at low Ci, while downregulation occurs when high Ci saturates photosynthesis and causes stomatal closure.

Proper Installation of Replacement Windows | Efficient Windows

Science.gov (United States)

Collaborative Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring

Performance Standards for Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Benefits of Efficient Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Assessing Window Replacement Options | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Windows for New Construction | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

On the DAMA and CoGeNT Modulations

DEFF Research Database (Denmark)

Frandsen, Mads Toudal; Kahlhoefer, Felix; March-Russell, John

2011-01-01

DAMA observes an annual modulation in their event rate, as might be expected from dark matter scatterings, while CoGeNT has reported evidence for a similar modulation. The simplest interpretation of these findings in terms of dark matter-nucleus scatterings is excluded by other direct detection...... constraints, while inelasticity enhances the annual modulation fraction of the signal, bringing the CoGeNT and CDMS results into better agreement....

A tandem queue with delayed server release

OpenAIRE

Nawijn, W.M.

1997-01-01

We consider a tandem queue with two stations. The rst station is an s-server queue with Poisson arrivals and exponential service times. After terminating his service in the rst station, a customer enters the second station to require service at an exponential single server, while in the meantime he is blocking his server in station 1 until he completes service in station 2, whereupon the server in station 1 is released. An analysis of the generating function of the simultaneous probability di...

TogoDoc server/client system: smart recommendation and efficient management of life science literature.

Directory of Open Access Journals (Sweden)

Wataru Iwasaki

Full Text Available In this paper, we describe a server/client literature management system specialized for the life science domain, the TogoDoc system (Togo, pronounced Toe-Go, is a romanization of a Japanese word for integration. The server and the client program cooperate closely over the Internet to provide life scientists with an effective literature recommendation service and efficient literature management. The content-based and personalized literature recommendation helps researchers to isolate interesting papers from the "tsunami" of literature, in which, on average, more than one biomedical paper is added to MEDLINE every minute. Because researchers these days need to cover updates of much wider topics to generate hypotheses using massive datasets obtained from public databases or omics experiments, the importance of having an effective literature recommendation service is rising. The automatic recommendation is based on the content of personal literature libraries of electronic PDF papers. The client program automatically analyzes these files, which are sometimes deeply buried in storage disks of researchers' personal computers. Just saving PDF papers to the designated folders makes the client program automatically analyze and retrieve metadata, rename file names, synchronize the data to the server, and receive the recommendation lists of newly published papers, thus accomplishing effortless literature management. In addition, the tag suggestion and associative search functions are provided for easy classification of and access to past papers (researchers who read many papers sometimes only vaguely remember or completely forget what they read in the past. The TogoDoc system is available for both Windows and Mac OS X and is free. The TogoDoc Client software is available at http://tdc.cb.k.u-tokyo.ac.jp/, and the TogoDoc server is available at https://docman.dbcls.jp/pubmed_recom.

TogoDoc server/client system: smart recommendation and efficient management of life science literature.

Science.gov (United States)

Iwasaki, Wataru; Yamamoto, Yasunori; Takagi, Toshihisa

2010-12-13

In this paper, we describe a server/client literature management system specialized for the life science domain, the TogoDoc system (Togo, pronounced Toe-Go, is a romanization of a Japanese word for integration). The server and the client program cooperate closely over the Internet to provide life scientists with an effective literature recommendation service and efficient literature management. The content-based and personalized literature recommendation helps researchers to isolate interesting papers from the "tsunami" of literature, in which, on average, more than one biomedical paper is added to MEDLINE every minute. Because researchers these days need to cover updates of much wider topics to generate hypotheses using massive datasets obtained from public databases or omics experiments, the importance of having an effective literature recommendation service is rising. The automatic recommendation is based on the content of personal literature libraries of electronic PDF papers. The client program automatically analyzes these files, which are sometimes deeply buried in storage disks of researchers' personal computers. Just saving PDF papers to the designated folders makes the client program automatically analyze and retrieve metadata, rename file names, synchronize the data to the server, and receive the recommendation lists of newly published papers, thus accomplishing effortless literature management. In addition, the tag suggestion and associative search functions are provided for easy classification of and access to past papers (researchers who read many papers sometimes only vaguely remember or completely forget what they read in the past). The TogoDoc system is available for both Windows and Mac OS X and is free. The TogoDoc Client software is available at http://tdc.cb.k.u-tokyo.ac.jp/, and the TogoDoc server is available at https://docman.dbcls.jp/pubmed_recom.

Parallel Computing Using Web Servers and "Servlets".

Science.gov (United States)

Lo, Alfred; Bloor, Chris; Choi, Y. K.

2000-01-01

Describes parallel computing and presents inexpensive ways to implement a virtual parallel computer with multiple Web servers. Highlights include performance measurement of parallel systems; models for using Java and intranet technology including single server, multiple clients and multiple servers, single client; and a comparison of CGI (common…

JAFA: a protein function annotation meta-server

DEFF Research Database (Denmark)

Friedberg, Iddo; Harder, Tim; Godzik, Adam

2006-01-01

Annotations, or JAFA server. JAFA queries several function prediction servers with a protein sequence and assembles the returned predictions in a legible, non-redundant format. In this manner, JAFA combines the predictions of several servers to provide a comprehensive view of what are the predicted functions...

A polling model with an autonomous server

NARCIS (Netherlands)

de Haan, Roland; Boucherie, Richardus J.; van Ommeren, Jan C.W.

Polling models are used as an analytical performance tool in several application areas. In these models, the focus often is on controlling the operation of the server as to optimize some performance measure. For several applications, controlling the server is not an issue as the server moves

Passive Detection of Misbehaving Name Servers

Science.gov (United States)

2013-10-01

name servers that changed IP address five or more times in a month. Solid red line indicates those servers possibly linked to pharmaceutical scams . 12...malicious and stated that fast-flux hosting “is considered one of the most serious threats to online activities today” [ICANN 2008, p. 2]. The...that time, apparently independent of filters on name-server flux, a large number of pharmaceutical scams1 were taken down. These scams apparently

Learning from Clostridium novyi-NT: How to defeat cancer

Directory of Open Access Journals (Sweden)

Li Wang

2018-01-01

Full Text Available Side effects associated with conventional anticancer therapies have prompted the new idea of solid tumor treatment strategy. One of them is using bacteria explored as potential antitumor agents over more than one century. Notably, the ideal therapy is a specifical target to tumors with limited toxicity. Here, we take “Clostridium novyi” for the search keyword in the PubMed from 2000 to 2015 and describe that C. novyi-NT spores act as “Trojan horse” for bacteriolytic therapy. This therapy is based on the fact that the live and attenuated obligate anaerobic bacteria are capable of binary fission selectively in anoxic areas of solid tumors and direct tumoricidal effects. Our succinct review mainly concentrates on the potential mechanisms of combination bacteriolytic therapy, an effective and safe tumor therapy with the help of C. novyi-NT. Importantly, C. novyi-NT spores were shown to induce solid tumor regression and exhibit the property to initiate an immune response. Therefore, C. novyi-NT spores should be an effective and safe tumor therapy.

Permeability of the blood-brain barrier to the neurotensin8-13 analog NT1.

Science.gov (United States)

Banks, W A; Wustrow, D J; Cody, W L; Davis, M D; Kastin, A J

1995-10-09

Neurotensin (NT) has been suggested to be a neuropeptide with therapeutic potential. We used multiple-time regression analysis to measure the unidirectional influx constant (Ki) of a tritiated analog of NT8-13, NT1, with improved metabolic stability. The Ki of [3H]NT1 across the blood-brain barrier (BBB) was 5.12(10(-4)) ml/g-min and was decreased 66% by unlabeled NT1 system. The amount of NT1 crossing the BBB, 0.087% of the injected dose per gram of brain, is consistent with its exerting central effects after peripheral administration. The stable [3H]NT1 crossed the BBB in intact form as assessed by HPLC and completely crossed the endothelial cells that comprise the BBB as assessed by the capillary depletion method. The presence of a transport system could be important for the development of NT analogs.

Server-side Statistics Scripting in PHP

Directory of Open Access Journals (Sweden)

Jan de Leeuw

1997-06-01

Full Text Available On the UCLA Statistics WWW server there are a large number of demos and calculators that can be used in statistics teaching and research. Some of these demos require substantial amounts of computation, others mainly use graphics. These calculators and demos are implemented in various different ways, reflecting developments in WWW based computing. As usual, one of the main choices is between doing the work on the client-side (i.e. in the browser or on the server-side (i.e. on our WWW server. Obviously, client-side computation puts fewer demands on the server. On the other hand, it requires that the client downloads Java applets, or installs plugins and/or helpers. If JavaScript is used, client-side computations will generally be slow. We also have to assume that the client is installed properly, and has the required capabilities. Requiring too much on the client-side has caused browsing machines such as Netscape Communicator to grow beyond all reasonable bounds, both in size and RAM requirements. Moreover requiring Java and JavaScript rules out such excellent browsers as Lynx or Emacs W3. For server-side computing, we can configure the server and its resources ourselves, and we need not worry about browser capabilities and configuration. Nothing needs to be downloaded, except the usual HTML pages and graphics. In the same way as on the client side, there is a scripting solution, where code is interpreted, or a ob ject-code solution using compiled code. For the server-side scripting, we use embedded languages, such as PHP/FI. The scripts in the HTML pages are interpreted by a CGI program, and the output of the CGI program is send to the clients. Of course the CGI program is compiled, but the statistics procedures will usually be interpreted, because PHP/FI does not have the appropriate functions in its scripting language. This will tend to be slow, because embedded languages do not deal efficiently with loops and similar constructs. Thus a first

Triple-server blind quantum computation using entanglement swapping

Science.gov (United States)

Li, Qin; Chan, Wai Hong; Wu, Chunhui; Wen, Zhonghua

2014-04-01

Blind quantum computation allows a client who does not have enough quantum resources or technologies to achieve quantum computation on a remote quantum server such that the client's input, output, and algorithm remain unknown to the server. Up to now, single- and double-server blind quantum computation have been considered. In this work, we propose a triple-server blind computation protocol where the client can delegate quantum computation to three quantum servers by the use of entanglement swapping. Furthermore, the three quantum servers can communicate with each other and the client is almost classical since one does not require any quantum computational power, quantum memory, and the ability to prepare any quantum states and only needs to be capable of getting access to quantum channels.

HYDRAULICS AND MIXING EVALUATIONS FOR NT-21/41 TANKS

Energy Technology Data Exchange (ETDEWEB)

Lee, S.; Barnes, O.

2014-11-17

The hydraulic results demonstrate that pump head pressure of 20 psi recirculates about 5.6 liters/min flowrate through the existing 0.131-inch orifice when a valve connected to NT-41 is closed. In case of the valve open to NT-41, the solution flowrates to HB-Line tanks, NT-21 and NT-41, are found to be about 0.5 lpm and 5.2 lpm, respectively. The modeling calculations for the mixing operations of miscible fluids contained in the HB-Line tank NT-21 were performed by taking a three-dimensional Computational Fluid Dynamics (CFD) approach. The CFD modeling results were benchmarked against the literature results and the previous SRNL test results to validate the model. Final performance calculations were performed for the nominal case by using the validated model to quantify the mixing time for the HB-Line tank. The results demonstrate that when a pump recirculates a solution volume of 5.7 liters every minute out of the 72-liter tank contents containing two acid solutions of 2.7 M and 0 M concentrations (i.e., water), a minimum mixing time of 1.5 hours is adequate for the tank contents to get the tank contents adequately mixed. In addition, the sensitivity results for the tank contents of 8 M existing solution and 1.5 M incoming species show that the mixing time takes about 2 hours to get the solutions mixed.

Effect of video server topology on contingency capacity requirements

Science.gov (United States)

Kienzle, Martin G.; Dan, Asit; Sitaram, Dinkar; Tetzlaff, William H.

1996-03-01

Video servers need to assign a fixed set of resources to each video stream in order to guarantee on-time delivery of the video data. If a server has insufficient resources to guarantee the delivery, it must reject the stream request rather than slowing down all existing streams. Large scale video servers are being built as clusters of smaller components, so as to be economical, scalable, and highly available. This paper uses a blocking model developed for telephone systems to evaluate video server cluster topologies. The goal is to achieve high utilization of the components and low per-stream cost combined with low blocking probability and high user satisfaction. The analysis shows substantial economies of scale achieved by larger server images. Simple distributed server architectures can result in partitioning of resources with low achievable resource utilization. By comparing achievable resource utilization of partitioned and monolithic servers, we quantify the cost of partitioning. Next, we present an architecture for a distributed server system that avoids resource partitioning and results in highly efficient server clusters. Finally, we show how, in these server clusters, further optimizations can be achieved through caching and batching of video streams.

RANCANG BANGUN PERANGKAT LUNAK MANAJEMEN DATABASE SQL SERVER BERBASIS WEB

Directory of Open Access Journals (Sweden)

Muchammad Husni

2005-01-01

Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 Microsoft SQL Server merupakan aplikasi desktop database server yang bersifat client/server, karena memiliki komponen client, yang  berfungsi menampilkan dan memanipulasi data; serta komponen server yang berfungsi menyimpan, memanggil, dan mengamankan database. Operasi-operasi manajemen semua server database dalam jaringan dilakukan administrator database dengan menggunakan tool administratif utama SQL Server yang bernama Enterprise Manager. Hal ini mengakibatkan administrator database hanya bisa  melakukan operasi-operasi tersebut di komputer yang telah diinstalasi Microsoft SQL Server. Pada penelitian ini, dirancang suatu aplikasi berbasis web dengan menggunakan ASP.Net untuk melakukan pengaturan database server. Aplikasi ini menggunakan ADO.NET yang memanfaatkan Transact-SQL dan stored procedure pada server untuk melakukan operasi-operasi manajemen database pada suatu server database SQL, dan menampilkannya ke dalam web. Administrator database bisa menjalankan aplikasi berbasis web tersebut dari komputer mana saja pada jaringan dan melakukan koneksi ke server database SQL dengan menggunakan web browser. Dengan demikian memudahkan administrator melakukan tugasnya tanpa harus menggunakan komputer server.   Kata Kunci : Transact-SQL, ASP.Net, ADO.NET, SQL Server

Mastering Citrix XenServer

CERN Document Server

Reed, Martez

2014-01-01

If you are an administrator who is looking to gain a greater understanding of how to design and implement a virtualization solution based on Citrix® XenServer®, then this book is for you. The book will serve as an excellent resource for those who are already familiar with other virtualization platforms, such as Microsoft Hyper-V or VMware vSphere.The book assumes that you have a good working knowledge of servers, networking, and storage technologies.

Securing SQL Server Protecting Your Database from Attackers

CERN Document Server

Cherry, Denny

2012-01-01

Written by Denny Cherry, a Microsoft MVP for the SQL Server product, a Microsoft Certified Master for SQL Server 2008, and one of the biggest names in SQL Server today, Securing SQL Server, Second Edition explores the potential attack vectors someone can use to break into your SQL Server database as well as how to protect your database from these attacks. In this book, you will learn how to properly secure your database from both internal and external threats using best practices and specific tricks the author uses in his role as an independent consultant while working on some of the largest

Securing SQL server protecting your database from attackers

CERN Document Server

Cherry, Denny

2015-01-01

SQL server is the most widely-used database platform in the world, and a large percentage of these databases are not properly secured, exposing sensitive customer and business data to attack. In Securing SQL Server, Third Edition, you will learn about the potential attack vectors that can be used to break into SQL server databases as well as how to protect databases from these attacks. In this book, Denny Cherry - a Microsoft SQL MVP and one of the biggest names in SQL server - will teach you how to properly secure an SQL server database from internal and external threats using best practic

Server farms with setup costs

NARCIS (Netherlands)

Gandhi, A.; Harchol-Balter, M.; Adan, I.J.B.F.

2010-01-01

In this paper we consider server farms with a setup cost. This model is common in manufacturing systems and data centers, where there is a cost to turn servers on. Setup costs always take the form of a time delay, and sometimes there is additionally a power penalty, as in the case of data centers.

TBI server: a web server for predicting ion effects in RNA folding.

Science.gov (United States)

Zhu, Yuhong; He, Zhaojian; Chen, Shi-Jie

2015-01-01

Metal ions play a critical role in the stabilization of RNA structures. Therefore, accurate prediction of the ion effects in RNA folding can have a far-reaching impact on our understanding of RNA structure and function. Multivalent ions, especially Mg²⁺, are essential for RNA tertiary structure formation. These ions can possibly become strongly correlated in the close vicinity of RNA surface. Most of the currently available software packages, which have widespread success in predicting ion effects in biomolecular systems, however, do not explicitly account for the ion correlation effect. Therefore, it is important to develop a software package/web server for the prediction of ion electrostatics in RNA folding by including ion correlation effects. The TBI web server http://rna.physics.missouri.edu/tbi_index.html provides predictions for the total electrostatic free energy, the different free energy components, and the mean number and the most probable distributions of the bound ions. A novel feature of the TBI server is its ability to account for ion correlation and ion distribution fluctuation effects. By accounting for the ion correlation and fluctuation effects, the TBI server is a unique online tool for computing ion-mediated electrostatic properties for given RNA structures. The results can provide important data for in-depth analysis for ion effects in RNA folding including the ion-dependence of folding stability, ion uptake in the folding process, and the interplay between the different energetic components.

TBI server: a web server for predicting ion effects in RNA folding.

Directory of Open Access Journals (Sweden)

Yuhong Zhu

Full Text Available Metal ions play a critical role in the stabilization of RNA structures. Therefore, accurate prediction of the ion effects in RNA folding can have a far-reaching impact on our understanding of RNA structure and function. Multivalent ions, especially Mg²⁺, are essential for RNA tertiary structure formation. These ions can possibly become strongly correlated in the close vicinity of RNA surface. Most of the currently available software packages, which have widespread success in predicting ion effects in biomolecular systems, however, do not explicitly account for the ion correlation effect. Therefore, it is important to develop a software package/web server for the prediction of ion electrostatics in RNA folding by including ion correlation effects.The TBI web server http://rna.physics.missouri.edu/tbi_index.html provides predictions for the total electrostatic free energy, the different free energy components, and the mean number and the most probable distributions of the bound ions. A novel feature of the TBI server is its ability to account for ion correlation and ion distribution fluctuation effects.By accounting for the ion correlation and fluctuation effects, the TBI server is a unique online tool for computing ion-mediated electrostatic properties for given RNA structures. The results can provide important data for in-depth analysis for ion effects in RNA folding including the ion-dependence of folding stability, ion uptake in the folding process, and the interplay between the different energetic components.

Replacement Windows for Existing Homes Homes | Efficient Windows

Science.gov (United States)

Collaborative Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring

Design Guidance for New Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Selection Process for New Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Selection Process for Replacement Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Design Guidance for Replacement Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Proper Installation of New Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

The N-terminal neurotensin fragment, NT1-11, inhibits cortisol secretion by human adrenocortical cells.

Science.gov (United States)

Sicard, Flavie; Contesse, Vincent; Lefebvre, Hervé; Ait-Ali, Djida; Gras, Marjorie; Cartier, Dorthe; Decker, Annick; Chartrel, Nicolas; Anouar, Youssef; Vaudry, Hubert; Delarue, Catherine

2006-08-01

Neurotensin (NT) modulates corticosteroid secretion from the mammalian adrenal gland. The objective of this study was to investigate the possible involvement of NT in the control of cortisol secretion in the human adrenal gland. In vitro studies were conducted on cultured human adrenocortical cells. This study was conducted in a university research laboratory. Adrenal explants from patients undergoing expanded nephrectomy for kidney cancer were studied. Cortisol secretion from cultured adrenocortical cells was measured. NT1-11, the N-terminal fragment of NT, dose-dependently inhibited basal and ACTH-stimulated cortisol production by human adrenocortical cells in primary culture. In contrast, NT had no influence on cortisol output at concentrations up to 10(-6) m. HPLC and RT-PCR analyses failed to detect any significant amounts of NT and NT mRNA, respectively, in adrenal extracts. Molecular and pharmacological studies were performed to determine the type of NT receptor involved in the corticostatic effect of NT1-11. RT-PCR analysis revealed the expression of NT receptor type (NTR) 3 mRNA but not NTR1 and NTR2 mRNAs in the human adrenal tissue. However, the pharmacological profile of the adrenal NT1-11 receptor was different from that of NTR3, indicating that this receptor type is not involved in the action of NT1-11 on corticosteroidogenesis. Our results indicate that NT1-11 may act as an endocrine factor to inhibit cortisol secretion through activation of a receptor distinct from the classical NTR1, NTR2, and NTR3.

Strength and Fatigue of NT551 Silicon Nitride and NT551 Diesel Exhaust Valves

Energy Technology Data Exchange (ETDEWEB)

Andrews, M.J.; Wereszczak, A.A.; Kirkland, T.P.; Breder, K.

2000-02-01

The content of this report is excerpted from Mark Andrew's Ph.D. Thesis (Andrews, 1999), which was funded by a DOEYOTT High Temperature Materials Laboratory Graduate Fellowship. It involves the characterization of NT551 and valves fabricated with it. Greater detail of the described issues may be found in that reference or through communications with Andrew Wereszczak.

Using Servers to Enhance Control System Capability

International Nuclear Information System (INIS)

Bickley, M.; Bowling, B. A.; Bryan, D. A.; Zeijts, J. van; White, K. S.; Witherspoon, S.

1999-01-01

Many traditional control systems include a distributed collection of front end machines to control hardware. Backend tools are used to view, modify, and record the signals generated by these front end machines. Software servers, which are a middleware layer between the front and back ends, can improve a control system in several ways. Servers can enable on-line processing of raw data, and consolidation of functionality. It many cases data retrieved from the front end must be processed in order to convert the raw data into useful information. These calculations are often redundantly performance by different programs, frequently offline. Servers can monitor the raw data and rapidly perform calculations, producing new signals which can be treated like any other control system signal, and can be used by any back end application. Algorithms can be incorporated to actively modify signal values in the control system based upon changes of other signals, essentially producing feedback in a control system. Servers thus increase the flexibility of a control system. Lastly, servers running on inexpensive UNIXworkstations can relay or cache frequently needed information, reducing the load on front end hardware by functioning as concentrators. Rather than many back end tools connecting directly to the front end machines, increasing the work load of these machines, they instead connect to the server. Servers like those discussed above have been used successfully at the Thomas Jefferson National Accelerator Facility to provide functionality such as beam steering, fault monitoring, storage of machine parameters, and on-line data processing. The authors discuss the potential uses of such servers, and share the results of work performed to date

Server-Aided Verification Signature with Privacy for Mobile Computing

Directory of Open Access Journals (Sweden)

Lingling Xu

2015-01-01

Full Text Available With the development of wireless technology, much data communication and processing has been conducted in mobile devices with wireless connection. As we know that the mobile devices will always be resource-poor relative to static ones though they will improve in absolute ability, therefore, they cannot process some expensive computational tasks due to the constrained computational resources. According to this problem, server-aided computing has been studied in which the power-constrained mobile devices can outsource some expensive computation to a server with powerful resources in order to reduce their computational load. However, in existing server-aided verification signature schemes, the server can learn some information about the message-signature pair to be verified, which is undesirable especially when the message includes some secret information. In this paper, we mainly study the server-aided verification signatures with privacy in which the message-signature pair to be verified can be protected from the server. Two definitions of privacy for server-aided verification signatures are presented under collusion attacks between the server and the signer. Then based on existing signatures, two concrete server-aided verification signature schemes with privacy are proposed which are both proved secure.

The HydroServer Platform for Sharing Hydrologic Data

Science.gov (United States)

Tarboton, D. G.; Horsburgh, J. S.; Schreuders, K.; Maidment, D. R.; Zaslavsky, I.; Valentine, D. W.

2010-12-01

The CUAHSI Hydrologic Information System (HIS) is an internet based system that supports sharing of hydrologic data. HIS consists of databases connected using the Internet through Web services, as well as software for data discovery, access, and publication. The HIS system architecture is comprised of servers for publishing and sharing data, a centralized catalog to support cross server data discovery and a desktop client to access and analyze data. This paper focuses on HydroServer, the component developed for sharing and publishing space-time hydrologic datasets. A HydroServer is a computer server that contains a collection of databases, web services, tools, and software applications that allow data producers to store, publish, and manage the data from an experimental watershed or project site. HydroServer is designed to permit publication of data as part of a distributed national/international system, while still locally managing access to the data. We describe the HydroServer architecture and software stack, including tools for managing and publishing time series data for fixed point monitoring sites as well as spatially distributed, GIS datasets that describe a particular study area, watershed, or region. HydroServer adopts a standards based approach to data publication, relying on accepted and emerging standards for data storage and transfer. CUAHSI developed HydroServer code is free with community code development managed through the codeplex open source code repository and development system. There is some reliance on widely used commercial software for general purpose and standard data publication capability. The sharing of data in a common format is one way to stimulate interdisciplinary research and collaboration. It is anticipated that the growing, distributed network of HydroServers will facilitate cross-site comparisons and large scale studies that synthesize information from diverse settings, making the network as a whole greater than the sum of its

Web server's reliability improvements using recurrent neural networks

DEFF Research Database (Denmark)

Madsen, Henrik; Albu, Rǎzvan-Daniel; Felea, Ioan

2012-01-01

In this paper we describe an interesting approach to error prediction illustrated by experimental results. The application consists of monitoring the activity for the web servers in order to collect the specific data. Predicting an error with severe consequences for the performance of a server (t...... usage, network usage and memory usage. We collect different data sets from monitoring the web server's activity and for each one we predict the server's reliability with the proposed recurrent neural network. © 2012 Taylor & Francis Group...

Windows

DEFF Research Database (Denmark)

Heiselberg, Per; Svidt, Kjeld; Nielsen, Peter V.

In natural ventilation systems fresh air is often provided through opening of windows. However, the knowledge of the performance of windows is rather limited. Computation of natural ventilation air flow through windows is most commonly made using discharge coefficients, that are regarded as being...... constant. The reported results show that the discharge coefficient for a window opening cannot be regarded as a constant and that it varies considerably with the size of the opening area, the window type and the temperature difference. Therefore, the use of a constant value can lead to serious errors...

The RNAsnp web server

DEFF Research Database (Denmark)

Radhakrishnan, Sabarinathan; Tafer, Hakim; Seemann, Ernst Stefan

2013-01-01

, are derived from extensive pre-computed tables of distributions of substitution effects as a function of gene length and GC content. Here, we present a web service that not only provides an interface for RNAsnp but also features a graphical output representation. In addition, the web server is connected...... to a local mirror of the UCSC genome browser database that enables the users to select the genomic sequences for analysis and visualize the results directly in the UCSC genome browser. The RNAsnp web server is freely available at: http://rth.dk/resources/rnasnp/....

Optimizing queries in SQL Server 2008

Directory of Open Access Journals (Sweden)

Ion LUNGU

2010-05-01

Full Text Available Starting from the need to develop efficient IT systems, we intend to review theoptimization methods and tools that can be used by SQL Server database administratorsand developers of applications based on Microsoft technology, focusing on the latestversion of the proprietary DBMS, SQL Server 2008. We’ll reflect on the objectives tobe considered in improving the performance of SQL Server instances, we will tackle themostly used techniques for analyzing and optimizing queries and we will describe the“Optimize for ad hoc workloads”, “Plan Freezing” and “Optimize for unknown" newoptions, accompanied by relevant code examples.

Energy Efficiency in Small Server Rooms: Field Surveys and Findings

Energy Technology Data Exchange (ETDEWEB)

Cheung, Iris [Hoi; Greenberg, Steve; Mahdavi, Roozbeh; Brown, Richard; Tschudi, William

2014-08-11

Fifty-seven percent of US servers are housed in server closets, server rooms, and localized data centers, in what are commonly referred to as small server rooms, which comprise 99percent of all server spaces in the US. While many mid-tier and enterprise-class data centers are owned by large corporations that consider energy efficiency a goal to minimize business operating costs, small server rooms typically are not similarly motivated. They are characterized by decentralized ownership and management and come in many configurations, which creates a unique set of efficiency challenges. To develop energy efficiency strategies for these spaces, we surveyed 30 small server rooms across eight institutions, and selected four of them for detailed assessments. The four rooms had Power Usage Effectiveness (PUE) values ranging from 1.5 to 2.1. Energy saving opportunities ranged from no- to low-cost measures such as raising cooling set points and better airflow management, to more involved but cost-effective measures including server consolidation and virtualization, and dedicated cooling with economizers. We found that inefficiencies mainly resulted from organizational rather than technical issues. Because of the inherent space and resource limitations, the most effective measure is to operate servers through energy-efficient cloud-based services or well-managed larger data centers, rather than server rooms. Backup power requirement, and IT and cooling efficiency should be evaluated to minimize energy waste in the server space. Utility programs are instrumental in raising awareness and spreading technical knowledge on server operation, and the implementation of energy efficiency measures in small server rooms.

DB2 9 for Linux, Unix, and Windows database administration certification study guide

CERN Document Server

Sanders, Roger E

2007-01-01

In DB2 9 for Linux, UNIX, and Windows Database Administration Certification Study Guide, Roger E. Sanders-one of the world's leading DB2 authors and an active participant in the development of IBM's DB2 certification exams-covers everything a reader needs to know to pass the DB2 9 UDB DBA Certification Test (731).This comprehensive study guide steps you through all of the topics that are covered on the test, including server management, data placement, database access, analyzing DB2 activity, DB2 utilities, high availability, security, and much more. Each chapter contains an extensive set of p

Server-Aided Two-Party Computation with Simultaneous Corruption

DEFF Research Database (Denmark)

Cascudo Pueyo, Ignacio; Damgård, Ivan Bjerre; Ranellucci, Samuel

We consider secure two-party computation in the client-server model where there are two adversaries that operate separately but simultaneously, each of them corrupting one of the parties and a restricted subset of servers that they interact with. We model security via the local universal composab......We consider secure two-party computation in the client-server model where there are two adversaries that operate separately but simultaneously, each of them corrupting one of the parties and a restricted subset of servers that they interact with. We model security via the local universal...

Cluster Server IPTV dengan Penjadwalan Algoritma Round Robin

Directory of Open Access Journals (Sweden)

Didik Aribowo

2016-03-01

Full Text Available Perkembangan teknologi informasi yang pesat, otomatis seiring juga dengan meningkatnya para pengguna yang terhubung pada jaringan internet. Berawal dari sebuah single server yang selalu mendapatkan request dari banyak user, perlahan tapi pasti akan terjadi overload dan crash sehingga berdampak pada request yang tidak dapat dilayani oleh single server. Desain arsitektur cluster dapat dibangun dengan menggunakan konsep network load balancing yang memungkinkan proses pengolahan data di share ke dalam beberapa komputer. Dalam penelitian ini menggunakan algoritma penjadwalan round robin sebagai solusi alternatif mengatasi permasalah overload data pada server yang dapat mempengaruhi kinerja sistem IPTV. Untuk  jumlah request yang digunakan dalam penelitian ini adalah 5000, 15000, 25000, dan 50000 request. Dengan metode tersebut, maka performansi algoritma penjawalan dapat diamati dengan menekankan pada parameter sebagai berikut, yaitu throughput, respon time, reply connection, dan error connection sehingga didapatkan algoritma penjadwalan terbaik dalam rangka optimalisasi cluster server IPTV. Secara otomatis dalam proses load balancing mampu mengurangi beban kerja setiap server sehingga tidak ada server yang overload dan memungkinkan server  menggunakan bandwidth  yang tersedia secara lebih efektif serta menyediakan akses yang cepat ke web browser yang dihosting. Implementasi webserver cluster dengan skema load balancing dapat memberikan alvalaibilitas sistem yang tetap terjaga dan skalabilitas yang cukup untuk dapat tetap melayani setiap request dari pengguna

BEBAN JARINGAN SAAT MENGAKSES EMAIL DARI BEBERAPA MAIL SERVER

Directory of Open Access Journals (Sweden)

Husni Thamrin

2017-01-01

Full Text Available Expensive internet facilities require prudent in its use both as a source of information and communication media. This paper discusses observations of the perceived burden of network bandwidth when accessing some of the mail server using a webmail application. Mail server in question consists of three commercial server and 2 non-commercial server. Data when it download home page, while logged in, open the email, and during idle logout recorded with sniffer Wireshark. Observations in various situations and scenarios indicate that access Yahoo email gives the network load is very high while the SquirrelMail gives the network load is very low than 5 other mail servers. For an institution, use a local mail server (institutional is highly recommended in the context of banddwidth savings.

Maintenance in Single-Server Queues: A Game-Theoretic Approach

Directory of Open Access Journals (Sweden)

Najeeb Al-Matar

2009-01-01

examine a single-server queue with bulk input and secondary work during server's multiple vacations. When the buffer contents become exhausted the server leaves the system to perform some diagnostic service of a minimum of L jobs clustered in packets of random sizes (event A. The server is not supposed to stay longer than T units of time (event B. The server returns to the system when A or B occurs, whichever comes first. On the other hand, he may not break service of a packet in a middle even if A or B occurs. Furthermore, the server waits for batches of customers to arrive if upon his return the queue is still empty. We obtain a compact and explicit form functional for the queueing process in equilibrium.

Transcriptional coactivator NT-PGC-1α promotes gluconeogenic gene expression and enhances hepatic gluconeogenesis.

Science.gov (United States)

Chang, Ji Suk; Jun, Hee-Jin; Park, Minsung

2016-10-01

The transcriptional coactivator PGC-1α plays a central role in hepatic gluconeogenesis. We previously reported that alternative splicing of the PGC-1α gene produces an additional transcript encoding the truncated protein NT-PGC-1α NT-PGC-1α is co-expressed with PGC-1α and highly induced by fasting in the liver. NT-PGC-1α regulates tissue-specific metabolism, but its role in the liver has not been investigated. Thus, the objective of this study was to determine the role of hepatic NT-PGC-1α in the regulation of gluconeogenesis. Adenovirus-mediated expression of NT-PGC-1α in primary hepatocytes strongly stimulated the expression of key gluconeogenic enzyme genes (PEPCK and G6Pase), leading to increased glucose production. To further understand NT-PGC-1α function in hepatic gluconeogenesis in vivo, we took advantage of a previously reported FL-PGC-1α -/- mouse line that lacks full-length PGC-1α (FL-PGC-1α) but retains a slightly shorter and functionally equivalent form of NT-PGC-1α (NT-PGC-1α 254 ). In FL-PGC-1α -/- mice, NT-PGC-1α 254 was induced by fasting in the liver and recruited to the promoters of PEPCK and G6Pase genes. The enrichment of NT-PGC-1α 254 at the promoters was closely associated with fasting-induced increase in PEPCK and G6Pase gene expression and efficient production of glucose from pyruvate during a pyruvate tolerance test in FL-PGC-1α -/- mice. Moreover, FL-PGC-1α -/- primary hepatocytes showed a significant increase in gluconeogenic gene expression and glucose production after treatment with dexamethasone and forskolin, suggesting that NT-PGC-1α 254 is sufficient to stimulate the gluconeogenic program in the absence of FL-PGC-1α Collectively, our findings highlight the role of hepatic NT-PGC-1α in stimulating gluconeogenic gene expression and glucose production. © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Locating Nearby Copies of Replicated Internet Servers

National Research Council Canada - National Science Library

Guyton, James D; Schwartz, Michael F

1995-01-01

In this paper we consider the problem of choosing among a collection of replicated servers focusing on the question of how to make choices that segregate client/server traffic according to network topology...

GeoServer beginner's guide

CERN Document Server

Youngblood, Brian

2013-01-01

Step-by-step instructions are included and the needs of a beginner are totally satisfied by the book. The book consists of plenty of examples with accompanying screenshots and code for an easy learning curve. You are a web developer with knowledge of server side scripting, and have experience with installing applications on the server. You have a desire to want more than Google maps, by offering dynamically built maps on your site with your latest geospatial data stored in MySQL, PostGIS, MsSQL or Oracle. If this is the case, this book is meant for you.

Server hardware trends

CERN Multimedia

CERN. Geneva

2014-01-01

This talk will cover the status of the current and upcoming offers on server platforms, focusing mainly on the processing and storage parts. Alternative solutions like Open Compute (OCP) will be quickly covered.

On-line single server dial-a-ride problems

NARCIS (Netherlands)

Feuerstein, E.; Stougie, L.

1998-01-01

In this paper results on the dial-a-ride problem with a single server are presented. Requests for rides consist of two points in a metric space, a source and a destination. A ride has to be made by the server from the source to the destination. The server travels at unit speed in the metric space

Distinct functional characteristics of levocabastine sensitive rat neurotensin NT2 receptor expressed in Chinese hamster ovary cells.

Science.gov (United States)

Yamada, M; Yamada, M; Lombet, A; Forgez, P; Rostène, W

1998-01-01

Neurotensin has been shown to produce pharmacological effects both in brain and periphery. Several of these effects are mediated by a high-affinity neurotensin NT1 receptor. On the other hand, a low-affinity levocabastine-sensitive neurotensin NT2 receptor was molecularly cloned from rodent brain recently. In this study, in contrast to NT1 receptor, levocabastine (a histamine H1 receptor antagonist) and SR48692 (an antagonist for NT1 receptor) strongly stimulated intracellular Ca2+ mobilization in transfected Chinese hamster ovary cells expressing rat NT2 receptor, thus acting as potent NT2 receptor. Furthermore, despite of their affinities for NT2 receptor, the Ca2+ responses to potent NT1 agonists, neurotensin or JMV449 ([Lys8-(CH2NH)-Lys9]Pro-Tyr-Ile-Leu, a peptidase resistant analogue of neurotensin) were much smaller than that observed with SR48692. These findings suggest that NT1 and NT2 receptors present distinct functional characteristics and that SR48692 may act as a potent agonist for NT2 receptor.

Personalized Pseudonyms for Servers in the Cloud

OpenAIRE

Xiao Qiuyu; Reiter Michael K.; Zhang Yinqian

2017-01-01

A considerable and growing fraction of servers, especially of web servers, is hosted in compute clouds. In this paper we opportunistically leverage this trend to improve privacy of clients from network attackers residing between the clients and the cloud: We design a system that can be deployed by the cloud operator to prevent a network adversary from determining which of the cloud’s tenant servers a client is accessing. The core innovation in our design is a PoPSiCl (pronounced “popsicle”), ...

Securing SQL Server Protecting Your Database from Attackers

CERN Document Server

Cherry, Denny

2011-01-01

There is a lot at stake for administrators taking care of servers, since they house sensitive data like credit cards, social security numbers, medical records, and much more. In Securing SQL Server you will learn about the potential attack vectors that can be used to break into your SQL Server database, and how to protect yourself from these attacks. Written by a Microsoft SQL Server MVP, you will learn how to properly secure your database, from both internal and external threats. Best practices and specific tricks employed by the author will also be revealed. Learn expert techniques to protec

Web Server Configuration for an Academic Intranet

National Research Council Canada - National Science Library

Baltzis, Stamatios

2000-01-01

.... One of the factors that boosted this ability was the evolution of the Web Servers. Using the web server technology man can be connected and exchange information with the most remote places all over the...

Implementation of SRPT Scheduling in Web Servers

National Research Council Canada - National Science Library

Harchol-Balter, Mor

2000-01-01

.... Experiments use the Linux operating system and the Flash web server. All experiments are repeated under a range of server loads and under both trace-based workloads and those generated by a Web workload generator...

NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients

Directory of Open Access Journals (Sweden)

Jacques Ducros

2017-01-01

Full Text Available Background. We aimed to evaluate the association between NT-proBNP and malnutrition in HD patients while taking into account the four established categories of parameters for diagnosis of protein energy wasting (PEW. Methods. A cross-sectional study was performed in Afro-Caribbean dialysis patients. One component in each of the 4 categories for the wasting syndrome was retained: serum albumin ≤ 38 g/L, BMI ≤ 23 Kg/m2, serum creatinine ≤ 818 µmol/L, and normalized protein catabolic rate (nPCR ≤ 0.8 g/kg/day. NT-proBNP was assessed using a chemiluminescence immunoassay. Two multivariate logistic regression models were performed to determine the parameters associated with high NT-proBNP concentrations. Results. In 207 HD patients, 16.9% had PEW (at least three components. LVEF lower than 60% was found in 13.8% of patients. NT-proBNP levels ranged from 125 to 33144 pg/mL. In model 1, high levels of NT-proBNP (≥6243 pg/mL were independently associated with PEW OR 14.2 (3.25–62.4, male gender 2.80 (1.22–6.57, hsCRP > 5 mg/L 3.90 (1.77–8.57, and dialysis vintage > 3 years 3.84 (1.35–10.8. In model 2, LVEF OR was 0.93 (0.88–0.98. NT-proBNP concentrations were significantly higher when the PEW component number was higher. Conclusion. In dialysis patients, high NT-proBNP levels must draw attention to cardiac function but also to nutritional status.

A Virtual Astronomical Research Machine in No Time (VARMiNT)

Science.gov (United States)

Beaver, John

2012-05-01

We present early results of using virtual machine software to help make astronomical research computing accessible to a wider range of individuals. Our Virtual Astronomical Research Machine in No Time (VARMiNT) is an Ubuntu Linux virtual machine with free, open-source software already installed and configured (and in many cases documented). The purpose of VARMiNT is to provide a ready-to-go astronomical research computing environment that can be freely shared between researchers, or between amateur and professional, teacher and student, etc., and to circumvent the often-difficult task of configuring a suitable computing environment from scratch. Thus we hope that VARMiNT will make it easier for individuals to engage in research computing even if they have no ready access to the facilities of a research institution. We describe our current version of VARMiNT and some of the ways it is being used at the University of Wisconsin - Fox Valley, a two-year teaching campus of the University of Wisconsin System, as a means to enhance student independent study research projects and to facilitate collaborations with researchers at other locations. We also outline some future plans and prospects.

Tandem queue with server slow-down

NARCIS (Netherlands)

Miretskiy, D.I.; Scheinhardt, W.R.W.; Mandjes, M.R.H.

2007-01-01

We study how rare events happen in the standard two-node tandem Jackson queue and in a generalization, the socalled slow-down network, see [2]. In the latter model the service rate of the first server depends on the number of jobs in the second queue: the first server slows down if the amount of

Characteristics and Energy Use of Volume Servers in the United States

Energy Technology Data Exchange (ETDEWEB)

Fuchs, H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Shehabi, A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ganeshalingam, M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Desroches, L. -B. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lim, B. [Fraunhofer Center for Sustainable Energy Systems, Boston, MA (United States); Roth, K. [Fraunhofer Center for Sustainable Energy Systems, Boston, MA (United States); Tsao, A. [Navigant Consulting Inc., Chicago, IL (United States)

2017-11-01

Servers’ field energy use remains poorly understood, given heterogeneous computing loads, configurable hardware and software, and operation over a wide range of management practices. This paper explores various characteristics of 1- and 2-socket volume servers that affect energy consumption, and quantifies the difference in power demand between higher-performing SPEC and ENERGY STAR servers and our best understanding of a typical server operating today. We first establish general characteristics of the U.S. installed base of volume servers from existing IDC data and the literature, before presenting information on server hardware configurations from data collection events at a major online retail website. We then compare cumulative distribution functions of server idle power across three separate datasets and explain the differences between them via examination of the hardware characteristics to which power draw is most sensitive. We find that idle server power demand is significantly higher than ENERGY STAR benchmarks and the industry-released energy use documented in SPEC, and that SPEC server configurations—and likely the associated power-scaling trends—are atypical of volume servers. Next, we examine recent trends in server power draw among high-performing servers across their full load range to consider how representative these trends are of all volume servers before inputting weighted average idle power load values into a recently published model of national server energy use. Finally, we present results from two surveys of IT managers (n=216) and IT vendors (n=178) that illustrate the prevalence of more-efficient equipment and operational practices in server rooms and closets; these findings highlight opportunities to improve the energy efficiency of the U.S. server stock.

Environment server. Digital field information archival technology

International Nuclear Information System (INIS)

Kita, Nobuyuki; Kita, Yasuyo; Yang, Hai-quan

2002-01-01

For the safety operation of nuclear power plants, it is important to store various information about plants for a long period and visualize those stored information as desired. The system called Environment Server is developed for realizing it. In this paper, the general concepts of Environment Server is explained and its partial implementation for archiving the image information gathered by inspection mobile robots into virtual world and visualizing them is described. An extension of Environment Server for supporting attention sharing is also briefly introduced. (author)

Scaling proprioceptor gene transcription by retrograde NT3 signaling.

Directory of Open Access Journals (Sweden)

Jun Lee

Full Text Available Cell-type specific intrinsic programs instruct neuronal subpopulations before target-derived factors influence later neuronal maturation. Retrograde neurotrophin signaling controls neuronal survival and maturation of dorsal root ganglion (DRG sensory neurons, but how these potent signaling pathways intersect with transcriptional programs established at earlier developmental stages remains poorly understood. Here we determine the consequences of genetic alternation of NT3 signaling on genome-wide transcription programs in proprioceptors, an important sensory neuron subpopulation involved in motor reflex behavior. We find that the expression of many proprioceptor-enriched genes is dramatically altered by genetic NT3 elimination, independent of survival-related activities. Combinatorial analysis of gene expression profiles with proprioceptors isolated from mice expressing surplus muscular NT3 identifies an anticorrelated gene set with transcriptional levels scaled in opposite directions. Voluntary running experiments in adult mice further demonstrate the maintenance of transcriptional adjustability of genes expressed by DRG neurons, pointing to life-long gene expression plasticity in sensory neurons.

Implementasi Cluster Server pada Raspberry Pi dengan Menggunakan Metode Load Balancing

Directory of Open Access Journals (Sweden)

Ridho Habi Putra

2016-06-01

Full Text Available Server merupakan bagian penting dalam sebuah layanan didalam jaringan komputer. Peran server dapat menentukan kualitas baik buruknya dari layanan tersebut. Kegagalan dari sebuah server bisa disebabkan oleh beberapa faktor diantaranya kerusakan perangkat keras, sistem jaringan serta aliran listrik. Salah satu solusi untuk mengatasi kegagalan server dalam suatu jaringan komputer adalah dengan melakukan clustering server.  Tujuan dari penelitian ini adalah untuk mengukur kemampuan Raspberry Pi (Raspi digunakan sebagai web server. Raspberry Pi yang digunakan menggunakan Raspberry Pi 2 Model B dengan menggunakan processor ARM Cortex-A7 berjalan pada frekuensi 900MHz dengan memiliki RAM 1GB. Sistem operasi yang digunakan pada Raspberry Pi adalah Linux Debian Wheezy. Konsep penelitian ini menggunakan empat buah perangkat Raspberry Pi dimana dua Raspi digunakan sebagai web server dan dua Raspi lainnya digunakan sebagai penyeimbang beban (Load Balancer serta database server. Metode yang digunakan dalam pembangunan cluster server ini menggunakan metode load balancing, dimana beban server bekerja secara merata di masing-masing node. Pengujian yang diterapkan dengan melakukan perbandingan kinerja dari Raspbery Pi yang menangani lalu lintas data secara tunggal tanpa menggunakan load balancer serta pengujian Raspberry Pi dengan menggunakan load balancer sebagai beban penyeimbang antara anggota cluster server.

Energy-Reduction Offloading Technique for Streaming Media Servers

Directory of Open Access Journals (Sweden)

Yeongpil Cho

2016-01-01

Full Text Available Recent growth in popularity of mobile video services raises a demand for one of the most popular and convenient methods of delivering multimedia data, video streaming. However, heterogeneity of currently existing mobile devices involves an issue of separate video transcoding for each type of mobile devices such as smartphones, tablet PCs, and smart TVs. As a result additional burden comes to media servers, which pretranscode multimedia data for number of clients. Regarding even higher increase of video data in the Internet in the future, the problem of media servers overload is impending. To struggle against the problem an offloading method is introduced in this paper. By the use of SorTube offloading framework video transcoding process is shifted from the centralized media server to the local offloading server. Thus, clients can receive personally customized video stream; meanwhile the overload of centralized servers is reduced.

The Development of Mobile Server for Language Courses

OpenAIRE

Tokumoto, Hiroko; Yoshida, Mitsunobu

2009-01-01

The aim of this paper is to introduce the conceptual design of the mobile server software "MY Server" for language teaching drafted by Tokumoto. It is to report how this software is designed and adopted effectively to Japanese language teaching. Most of the current server systems for education require facilities in a big scale including high-spec server machines, professional administrators, which naturally result in big budget projects that individual teachers or small size schools canno...

Probing dark matter streams with CoGeNT

International Nuclear Information System (INIS)

Natarajan, Aravind; Savage, Christopher; Freese, Katherine

2011-01-01

We examine the future sensitivity of CoGeNT to the presence of dark matter streams and find that consideration of streams in the data may lead to differences in the interpretation of the results. We show the allowed particle mass and cross section for different halo parameters, assuming spin-independent elastic scattering. As an example, we choose a stream with the same velocity profile as that of the Sagittarius stream (and in the Solar neighborhood) and find that, with an exposure of ∼10 kg yr, the CoGeNT results can be expected to exclude the standard-halo-model-only halo in favor of a standard halo model+stream halo at the 95% (99.7%) confidence level, provided the stream contributes 3% (5%) of the local dark matter density. The presence of a significant stream component may result in incorrect estimates of the particle mass and cross section unless the presence of the stream is taken into account. We conclude that the CoGeNT experiment is sensitive to streams and care should be taken to include the possibility of streams when analyzing experimental results.

Getting started with SQL Server 2014 administration

CERN Document Server

Ellis, Gethyn

2014-01-01

This is an easytofollow handson tutorial that includes real world examples of SQL Server 2014's new features. Each chapter is explained in a stepbystep manner which guides you to implement the new technology.If you want to create an highly efficient database server then this book is for you. This book is for database professionals and system administrators who want to use the added features of SQL Server 2014 to create a hybrid environment, which is both highly available and allows you to get the best performance from your databases.

ORF Alignment: NT_033778 [GENIUS II[Archive

Lifescience Database Archive (English)

Full Text Available de-binding protein [Periplaneta americana] ... pir||JQ0708 lipopolysaccharide-binding protein precurs... NT_033778 gi|24762680 >1qddA 8 141 113 253 1e-15 ... dbj|BAA00616.1| lipopolysacchari

Reliability of the Nidek NT-1000 non contact tonometer.

Science.gov (United States)

Van de Velde, T; Zeyen, T

1995-01-01

In this prospective study, we compared the intraocular pressure (IOP) readings of 100 patients measured with the Goldmann applanation tonometer and the Nidek NT-1000 pneumotonometer. The correlation coefficient between the Goldmann and Nidek readings was 0.86. On the average the pneumotonometer overestimated the intraocular pressure with 0.43 mm Hg. The Nidek NT-1000 non contact tonometer can be used for screening purposes provided an appropriately low IOP value is used to indicate the need for further assessment with the Goldman applanation tonometer.

Locating Hidden Servers

National Research Council Canada - National Science Library

Oeverlier, Lasse; Syverson, Paul F

2006-01-01

.... Announced properties include server resistance to distributed DoS. Both the EFF and Reporters Without Borders have issued guides that describe using hidden services via Tor to protect the safety of dissidents as well as to resist censorship...

ORF Alignment: NT_033779 [GENIUS II[Archive

Lifescience Database Archive (English)

Full Text Available n-like protein CL3 [Periplaneta americana] ... Length = 128 ... Query: 1 ... MVLDNQEDKLLTTTFLKSMGLSFTQSWHH... NT_033779 gi|21357645 >1qddA 26 143 127 254 1e-07 ... dbj|BAA82266.1| Cockroach lecti

Sincronización de Células de Tabaco (Nicotiana tabacum) NT-1

OpenAIRE

Ruiz, León F; Higareda, Ana E; Pardo, Marco A

2010-01-01

Se ha evaluado la capacidad sincronizante de afidicolina e hidroxiurea en cultivos de células de tabaco (Nicotiana tabacum) NT-1. Los cultivos sincronizados son poderosas herramientas en estudios moleculares y bioquímicos relacionados al ciclo celular y comúnmente se utilizan químicos para bloquear el ciclo celular. La línea celular de tabaco (Nicotiana tabacum) NT-1 proviene de la línea celular TBY-2, caracterizándose NT-1 por su menor velocidad de crecimiento y tamaño celular heterogéneo. L...

Energy-efficient server management; Energieeffizientes Servermanagement

Energy Technology Data Exchange (ETDEWEB)

Sauter, B.

2003-07-01

This final report for the Swiss Federal Office of Energy (SFOE) presents the results of a project that aimed to develop an automatic shut-down system for the servers used in typical electronic data processing installations to be found in small and medium-sized enterprises. The purpose of shutting down these computers - the saving of energy - is discussed. The development of a shutdown unit on the basis of a web-server that automatically shuts down the servers connected to it and then interrupts their power supply is described. The functions of the unit, including pre-set times for switching on and off, remote operation via the Internet and its interaction with clients connected to it are discussed. Examples of the system's user interface are presented.

Higher level of NT-proCNP in cerebrospinal fluid of patients with meningitis.

Science.gov (United States)

Tomasiuk, Ryszard; Lipowski, Dariusz; Szlufik, Stanislaw; Peplinska, Krystyna; Mikaszewska-Sokolewicz, Malgorzata

2016-02-12

Aminoterminal pro-C type natriuretic peptide (NT-proCNP) as an active form of CNP, has been recently proven to be a potential marker of sepsis and to be linked to inflammatory diseases. So far, there are no studies describing the level of NT-proCNP in meningitis. The purpose of this study was to evaluate the diagnostic value of NT-proCNP in cerebrospinal fluid (CSF) in patients with meningitis and to compare it with the serum level of CRP and procalcitonin (PCT) in this group of patients. The results were compared to serum levels of CRP, PCT and CSF levels of cytosis, protein and lactate. NT-proCNP levels were statistically significant between the control group and the meningitis groups (p=0.02; R=0.3). We also noted a correlation between the level of NT-proCNP in the CSF of all of the study groups (controls and meningitis patients) and the CSF levels of cytosis (p0.05; R=0.11). These results suggest that NT-proCNP could be a potential marker of meningitis, but it cannot be used to distinguish between the types of meningitis. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Windows Azure

CERN Document Server

Johnson, Bruce; Chambers, James; Garber, Danny; Malik, Jamal; Fazio, Adam

2013-01-01

A collection of five must-have Azure titles, from some of the biggest names in the field Available individually, but at a discounted rate for the collection, this bundle of five e-books covers key developer and IT topics of Windows Azure, including ASP.NET, mobile services, web sites, data storage, and the hybrid cloud. A host of Microsoft employees and MPVs come together to cover the biggest challenges that professionals face when working with Windows Azure. The e-books included are as follows: Windows Azure and ASP.NET MVC MigrationWindows Azure Mobile ServicesWindows Azure Web SitesWindows

Windows Based Data Sets for Evaluation of Robustness of Host Based Intrusion Detection Systems (IDS to Zero-Day and Stealth Attacks

Directory of Open Access Journals (Sweden)

Waqas Haider

2016-07-01

Full Text Available The Windows Operating System (OS is the most popular desktop OS in the world, as it has the majority market share of both servers and personal computing necessities. However, as its default signature-based security measures are ineffectual for detecting zero-day and stealth attacks, it needs an intelligent Host-based Intrusion Detection System (HIDS. Unfortunately, a comprehensive data set that reflects the modern Windows OS’s normal and attack surfaces is not publicly available. To fill this gap, in this paper two open data sets generated by the cyber security department of the Australian Defence Force Academy (ADFA are introduced, namely: Australian Defence Force Academy Windows Data Set (ADFA-WD; and Australian Defence Force Academy Windows Data Set with a Stealth Attacks Addendum (ADFA-WD: SAA. Statistical analysis results based on these data sets show that, due to the low foot prints of modern attacks and high similarity of normal and attacked data, both these data sets are complex, and highly intelligent Host based Anomaly Detection Systems (HADS design will be required.

Learning Windows Azure Mobile Services for Windows 8 and Windows Phone 8

CERN Document Server

Webber-Cross, Geoff

2014-01-01

This book is based around a case study game which was written for the book. This means that the chapters progress in a logical way and build upon lessons learned as we go. Real-world examples are provided for each topic that are practical and not given out-of-context so they can be applied directly to other applications.If you are a developer who wishes to build Windows 8 and Phone 8 applications and integrate them with Windows Azure Mobile Services, this book is for you. Basic C# and JavaScript skills are advantageous, as well as some knowledge of building Windows 8 or Windows Phone 8 applica

Installing and Testing a Server Operating System

Directory of Open Access Journals (Sweden)

Lorentz JÄNTSCHI

2003-08-01

Full Text Available The paper is based on the experience of the author with the FreeBSD server operating system administration on three servers in use under academicdirect.ro domain.The paper describes a set of installation, preparation, and administration aspects of a FreeBSD server.First issue of the paper is the installation procedure of FreeBSD operating system on i386 computer architecture. Discussed problems are boot disks preparation and using, hard disk partitioning and operating system installation using a existent network topology and a internet connection.Second issue is the optimization procedure of operating system, server services installation, and configuration. Discussed problems are kernel and services configuration, system and services optimization.The third issue is about client-server applications. Using operating system utilities calls we present an original application, which allows displaying the system information in a friendly web interface. An original program designed for molecular structure analysis was adapted for systems performance comparisons and it serves for a discussion of Pentium, Pentium II and Pentium III processors computation speed.The last issue of the paper discusses the installation and configuration aspects of dial-in service on a UNIX-based operating system. The discussion includes serial ports, ppp and pppd services configuration, ppp and tun devices using.

Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α.

Directory of Open Access Journals (Sweden)

Jihyun Kim

Full Text Available The β3-adrenergic receptor (AR signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β3-AR signaling highly induces the expression of transcriptional coactivator PGC-1α and its splice variant N-terminal (NT-PGC-1α, which in turn activate the transcription program of adaptive thermogenesis by co-activating a number of transcription factors. We previously reported that NT-PGC-1α is able to increase mitochondrial number and activity in cultured brown adipocytes by promoting the expression of mitochondrial and thermogenic genes. In the present study, we performed genome-wide profiling of NT-PGC-1α-responsive genes in brown adipocytes to identify genes potentially regulated by NT-PGC-1α. Canonical pathway analysis revealed that a number of genes upregulated by NT-PGC-1α are highly enriched in mitochondrial pathways including fatty acid transport and β-oxidation, TCA cycle and electron transport system, thus reinforcing the crucial role of NT-PGC-1α in the enhancement of mitochondrial function. Moreover, canonical pathway analysis of NT-PGC-1α-responsive genes identified several metabolic pathways including glycolysis and fatty acid synthesis. In order to validate the identified genes in vivo, we utilized the FL-PGC-1α-/- mouse that is deficient in full-length PGC-1α (FL-PGC-1α but expresses a slightly shorter and functionally equivalent form of NT-PGC-1α (NT-PGC-1α254. The β3-AR-induced increase of NT-PGC-1α254 in FL-PGC-1α-/- brown and white adipose tissue was closely associated with elevated expression of genes involved in thermogenesis, mitochondrial oxidative metabolism, glycolysis and fatty acid synthesis. Increased adipose tissue thermogenesis by β3-AR activation resulted in attenuation of adipose tissue expansion in FL-PGC-1α-/- adipose tissue under the high-fat diet condition. Together, the data strengthen our previous findings that NT-PGC-1�

Pro SQL Server 2012 relational database design and implementation

CERN Document Server

Davidson, Louis

2012-01-01

Learn effective and scalable database design techniques in a SQL Server environment. Pro SQL Server 2012 Relational Database Design and Implementation covers everything from design logic that business users will understand, all the way to the physical implementation of design in a SQL Server database. Grounded in best practices and a solid understanding of the underlying theory, Louis Davidson shows how to "get it right" in SQL Server database design and lay a solid groundwork for the future use of valuable business data. Gives a solid foundation in best practices and relational theory Covers

Foundations of SQL Server 2008 R2 Business Intelligence

CERN Document Server

Fouche, Guy

2011-01-01

Foundations of SQL Server 2008 R2 Business Intelligence introduces the entire exciting gamut of business intelligence tools included with SQL Server 2008. Microsoft has designed SQL Server 2008 to be more than just a database. It's a complete business intelligence (BI) platform. The database is at its core, and surrounding the core are tools for data mining, modeling, reporting, analyzing, charting, and integration with other enterprise-level software packages. SQL Server 2008 puts an incredible amount of BI functionality at your disposal. But how do you take advantage of it? That's what this

NT-proBNP on Cobas h 232 in point-of-care testing

DEFF Research Database (Denmark)

Gils, Charlotte; Ramanathan, R.; Breindahl, T.

2015-01-01

Background. NT-proBNP may be useful for ruling out heart failure in primary health care. In this study we examined the analytical quality of NT-proBNP in primary health care on the Cobas h 232 point-of-care instrument compared with measurements performed in a hospital laboratory. Materials...... and methods. Blood samples requested for NT-proBNP were collected in primary health care (n = 95) and in a hospital laboratory (n = 107). NT-proBNP was measured on-site on Cobas h 232 instruments both in primary health care centres and at the hospital laboratory and all samples were also analyzed...... with a comparison method at the hospital. Precision, trueness, accuracy, and lot-variation were determined at different concentration levels and evaluated according to acceptance criteria. Furthermore user-friendliness was assessed by questionnaires. Results. For Cobas h 232 repeatability CV was 8...

ORF Alignment: NT_033777 [GENIUS II[Archive

Lifescience Database Archive (English)

Full Text Available NT_033777 gi|24648160 >1mc2A 1 134 1 122 2e-29 ... gb|AAB20876.1| ammodytin L=myotoxi...c phospholipase A2 homologue [Vipera ... ammodytes=European viper, Peptide, 123 aa] ... Length

Building mail server on distributed computing system

International Nuclear Information System (INIS)

Akihiro Shibata; Osamu Hamada; Tomoko Oshikubo; Takashi Sasaki

2001-01-01

The electronic mail has become the indispensable function in daily job, and the server stability and performance are required. Using DCE and DFS we have built the distributed electronic mail sever, that is, servers such as SMTP, IMAP are distributed symmetrically, and provides the seamless access

Professional Team Foundation Server 2012

CERN Document Server

Blankenship, Ed; Holliday, Grant; Keller, Brian

2012-01-01

A comprehensive guide to using Microsoft Team Foundation Server 2012 Team Foundation Server has become the leading Microsoft productivity tool for software management, and this book covers what developers need to know to use it effectively. Fully revised for the new features of TFS 2012, it provides developers and software project managers with step-by-step instructions and even assists those who are studying for the TFS 2012 certification exam. You'll find a broad overview of TFS, thorough coverage of core functions, a look at extensibility options, and more, written by Microsoft ins

Professional Team Foundation Server 2010

CERN Document Server

Blankenship, Ed; Holliday, Grant; Keller, Brian

2011-01-01

Authoritative guide to TFS 2010 from a dream team of Microsoft insiders and MVPs!Microsoft Visual Studio Team Foundation Server (TFS) has evolved until it is now an essential tool for Microsoft?s Application Lifestyle Management suite of productivity tools, enabling collaboration within and among software development teams. By 2011, TFS will replace Microsoft?s leading source control system, VisualSourceSafe, resulting in an even greater demand for information about it. Professional Team Foundation Server 2010, written by an accomplished team of Microsoft insiders and Microsoft MVPs, provides

IBM WebSphere Application Server 80 Administration Guide

CERN Document Server

Robinson, Steve

2011-01-01

IBM WebSphere Application Server 8.0 Administration Guide is a highly practical, example-driven tutorial. You will be introduced to WebSphere Application Server 8.0, and guided through configuration, deployment, and tuning for optimum performance. If you are an administrator who wants to get up and running with IBM WebSphere Application Server 8.0, then this book is not to be missed. Experience with WebSphere and Java would be an advantage, but is not essential.

Life prediction and mechanical reliability of NT551 silicon nitride

Science.gov (United States)

Andrews, Mark Jay

The inert strength and fatigue performance of a diesel engine exhaust valve made from silicon nitride (Si3N4) ceramic were assessed. The Si3N4 characterized in this study was manufactured by Saint Gobain/Norton Industrial Ceramics and was designated as NT551. The evaluation was made utilizing a probabilistic life prediction algorithm that combined censored test specimen strength data with a Weibull distribution function and the stress field of the ceramic valve obtained from finite element analysis. The major assumptions of the life prediction algorithm are that the bulk ceramic material is isotropic and homogeneous and that the strength-limiting flaws are uniformly distributed. The results from mechanical testing indicated that NT551 was not a homogeneous ceramic and that its strength were functions of temperature, loading rate, and machining orientation. Fractographic analysis identified four different failure modes; 2 were identified as inhomogeneities that were located throughout the bulk of NT551 and were due to processing operations. The fractographic analysis concluded that the strength degradation of NT551 observed from the temperature and loading rate test parameters was due to a change of state that occurred in its secondary phase. Pristine and engine-tested valves made from NT551 were loaded to failure and the inert strengths were obtained. Fractographic analysis of the valves identified the same four failure mechanisms as found with the test specimens. The fatigue performance and the inert strength of the Si3N 4 valves were assessed from censored and uncensored test specimen strength data, respectively. The inert strength failure probability predictions were compared to the inert strength of the Si3N4 valves. The inert strength failure probability predictions were more conservative than the strength of the valves. The lack of correlation between predicted and actual valve strength was due to the nonuniform distribution of inhomogeneities present in NT

A polling model with an autonomous server

NARCIS (Netherlands)

de Haan, Roland; Boucherie, Richardus J.; van Ommeren, Jan C.W.

2009-01-01

This paper considers polling systems with an autonomous server that remain at a queue for an exponential amount of time before moving to a next queue incurring a generally distributed switch-over time. The server remains at a queue until the exponential visit time expires, also when the queue

Single-server queues with spatially distributed arrivals

NARCIS (Netherlands)

Kroese, Dirk; Schmidt, Volker

1994-01-01

Consider a queueing system where customers arrive at a circle according to a homogeneous Poisson process. After choosing their positions on the circle, according to a uniform distribution, they wait for a single server who travels on the circle. The server's movement is modelled by a Brownian motion

Evaluation of the Intel Nehalem-EX server processor

CERN Document Server

Jarp, S; Leduc, J; Nowak, A; CERN. Geneva. IT Department

2010-01-01

In this paper we report on a set of benchmark results recently obtained by the CERN openlab by comparing the 4-socket, 32-core Intel Xeon X7560 server with the previous generation 4-socket server, based on the Xeon X7460 processor. The Xeon X7560 processor represents a major change in many respects, especially the memory sub-system, so it was important to make multiple comparisons. In most benchmarks the two 4-socket servers were compared. It should be underlined that both servers represent the “top of the line” in terms of frequency. However, in some cases, it was important to compare systems that integrated the latest processor features, such as QPI links, Symmetric multithreading and over-clocking via Turbo mode, and in such situations the X7560 server was compared to a dual socket L5520 based system with an identical frequency of 2.26 GHz. Before summarizing the results we must stress the fact that benchmarking of modern processors is a very complex affair. One has to control (at least) the following ...

Client/server models for transparent, distributed computational resources

International Nuclear Information System (INIS)

Hammer, K.E.; Gilman, T.L.

1991-01-01

Client/server models are proposed to address issues of shared resources in a distributed, heterogeneous UNIX environment. Recent development of automated Remote Procedure Call (RPC) interface generator has simplified the development of client/server models. Previously, implementation of the models was only possible at the UNIX socket level. An overview of RPCs and the interface generator will be presented and will include a discussion of generation and installation of remote services, the RPC paradigm, and the three levels of RPC programming. Two applications, the Nuclear Plant Analyzer (NPA) and a fluids simulation using molecular modelling, will be presented to demonstrate how client/server models using RPCs and External Data Representations (XDR) have been used production/computation situations. The NPA incorporates a client/server interface for transferring/translation of TRAC or RELAP results from the UNICOS Cray to a UNIX workstation. The fluids simulation program utilizes the client/server model to access the Cray via a single function allowing it to become a shared co-processor to the workstation application. 5 refs., 6 figs

Introduction of an NT-proBNP assay to an acute admission unit--a 2-year audit.

LENUS (Irish Health Repository)

Murtagh, Gillian

2012-02-01

BACKGROUND: The differential diagnosis of dyspnoea is difficult due to the low predictive value of clinical and laboratory parameters. The elevated levels of NT-proBNP in congestive heart failure may improve diagnostic accuracy. We have evaluated the effect of the introduction of an NT-proBNP assay on hospital length of stay (LOS) and mortality. METHODS: There were 11,853 AMAU patient episodes in the 22 months study period (March 2005-Dec 2006). An NT-proBNP assay was requested in 657 (5.5%) of these. Comparison between categorical variables such as diagnosis, NT-proBNP testing, LOS, and in-hospital mortality was made using Chi-square tests. Literature review suggested that an NT-proBNP cut-off >or=5000 ng\\/L should predict acute in-patient mortality. Logistic regression analysis was used to examine the association between such an elevated NT-proBNP level and outcomes. RESULTS: Of the 396 patients with NT-proBNP <5000 ng\\/L, 8.1% died compared with 22.5% of the 178 patients dying with values >or=5000 ng\\/L (p<0.0001). An NT-proBNP >or=5000 ng\\/L was predictive of both LOS >or=9 days (odds ratios (OR) 1.54 (95% CI 1.06, 2.24: p=0.02) and LOS >or=14 days (OR=1.87 (95% CI 1.29, 2.71: p=0.0009). NT-proBNP requests increased over time, from 2.6% to 8.2% of all patients; the result fell in the diagnostic range for CHF in 60% of requests. CONCLUSION: The introduction of an NT-proBNP was reflected in an appropriate but rapidly increasing pattern of requests from clinicians. High NT-proBNP levels predicted in-hospital mortality and longer LOS in an acute medical population.

Single-server blind quantum computation with quantum circuit model

Science.gov (United States)

Zhang, Xiaoqian; Weng, Jian; Li, Xiaochun; Luo, Weiqi; Tan, Xiaoqing; Song, Tingting

2018-06-01

Blind quantum computation (BQC) enables the client, who has few quantum technologies, to delegate her quantum computation to a server, who has strong quantum computabilities and learns nothing about the client's quantum inputs, outputs and algorithms. In this article, we propose a single-server BQC protocol with quantum circuit model by replacing any quantum gate with the combination of rotation operators. The trap quantum circuits are introduced, together with the combination of rotation operators, such that the server is unknown about quantum algorithms. The client only needs to perform operations X and Z, while the server honestly performs rotation operators.

Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors.

Science.gov (United States)

Proenca, Catia C; Song, Minseok; Lee, Francis S

2016-08-01

Neurotrophins are a family of growth factors playing key roles in the survival, development, and function of neurons. The neurotrophins brain-derived neurotrophic factor (BDNF) and NT4 both bind to and activate TrkB receptors, however, they mediate distinct neuronal functions. The molecular mechanism of how TrkB activation by BDNF and NT4 leads to diverse outcomes is unknown. Here, we report that BDNF and NT4 lead to differential endocytic sorting of TrkB receptors resulting in diverse biological functions in cultured cortical neurons. Fluorescent microscopy and surface biotinylation experiments showed that both neurotrophins stimulate internalization of TrkB with similar kinetics. Exposure to BDNF for 2-3 h reduced the surface pool of TrkB receptors to half, whereas a longer treatment (4-5 h) with NT4 was necessary to achieve a similar level of down-regulation. Although BDNF and NT4 induced TrkB phosphorylation with similar intensities, BDNF induced more rapid ubiquitination and degradation of TrkB than NT4. Interestingly, TrkB receptor ubiquitination by these ligands have substantially different pH sensitivities, resulting in varying degrees of receptor ubiquitination at lower pH levels. Consequently, NT4 was capable of maintaining longer sustained downstream signaling activation that correlated with reduced TrkB ubiquitination at endosomal pH. Thus, by leading to altered endocytic trafficking itineraries for TrkB receptors, BDNF and NT4 elicit differential TrkB signaling in terms of duration, intensity, and specificity, which may contribute to their functional differences in vivo. The neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), both bind to and activate TrkB receptors, however, they mediate distinct neuronal functions. Here, we propose that BDNF and NT4 lead to differential endocytic sorting of TrkB receptors resulting in diverse biological functions. BDNF induces more rapid ubiquitination and degradation of TrkB than NT4

CPU Server

CERN Multimedia

The CERN computer centre has hundreds of racks like these. They are over a million times more powerful than our first computer in the 1960's. This tray is a 'dual-core' server. This means it effectively has two CPUs in it (eg. two of your home computers minimised to fit into a single box). Also note the copper cooling fins, to help dissipate the heat.

A tandem queue with delayed server release

NARCIS (Netherlands)

Nawijn, W.M.

1997-01-01

We consider a tandem queue with two stations. The rst station is an s-server queue with Poisson arrivals and exponential service times. After terminating his service in the rst station, a customer enters the second station to require service at an exponential single server, while in the meantime he

Design and implementation of streaming media server cluster based on FFMpeg.

Science.gov (United States)

Zhao, Hong; Zhou, Chun-long; Jin, Bao-zhao

2015-01-01

Poor performance and network congestion are commonly observed in the streaming media single server system. This paper proposes a scheme to construct a streaming media server cluster system based on FFMpeg. In this scheme, different users are distributed to different servers according to their locations and the balance among servers is maintained by the dynamic load-balancing algorithm based on active feedback. Furthermore, a service redirection algorithm is proposed to improve the transmission efficiency of streaming media data. The experiment results show that the server cluster system has significantly alleviated the network congestion and improved the performance in comparison with the single server system.

Design and Implementation of Streaming Media Server Cluster Based on FFMpeg

Science.gov (United States)

Zhao, Hong; Zhou, Chun-long; Jin, Bao-zhao

2015-01-01

Poor performance and network congestion are commonly observed in the streaming media single server system. This paper proposes a scheme to construct a streaming media server cluster system based on FFMpeg. In this scheme, different users are distributed to different servers according to their locations and the balance among servers is maintained by the dynamic load-balancing algorithm based on active feedback. Furthermore, a service redirection algorithm is proposed to improve the transmission efficiency of streaming media data. The experiment results show that the server cluster system has significantly alleviated the network congestion and improved the performance in comparison with the single server system. PMID:25734187

PockDrug-Server: a new web server for predicting pocket druggability on holo and apo proteins.

Science.gov (United States)

Hussein, Hiba Abi; Borrel, Alexandre; Geneix, Colette; Petitjean, Michel; Regad, Leslie; Camproux, Anne-Claude

2015-07-01

Predicting protein pocket's ability to bind drug-like molecules with high affinity, i.e. druggability, is of major interest in the target identification phase of drug discovery. Therefore, pocket druggability investigations represent a key step of compound clinical progression projects. Currently computational druggability prediction models are attached to one unique pocket estimation method despite pocket estimation uncertainties. In this paper, we propose 'PockDrug-Server' to predict pocket druggability, efficient on both (i) estimated pockets guided by the ligand proximity (extracted by proximity to a ligand from a holo protein structure) and (ii) estimated pockets based solely on protein structure information (based on amino atoms that form the surface of potential binding cavities). PockDrug-Server provides consistent druggability results using different pocket estimation methods. It is robust with respect to pocket boundary and estimation uncertainties, thus efficient using apo pockets that are challenging to estimate. It clearly distinguishes druggable from less druggable pockets using different estimation methods and outperformed recent druggability models for apo pockets. It can be carried out from one or a set of apo/holo proteins using different pocket estimation methods proposed by our web server or from any pocket previously estimated by the user. PockDrug-Server is publicly available at: http://pockdrug.rpbs.univ-paris-diderot.fr. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Construction of a nuclear data server using TCP/IP

Energy Technology Data Exchange (ETDEWEB)

Kawano, Toshihiko; Sakai, Osamu [Kyushu Univ., Fukuoka (Japan)

1997-03-01

We construct a nuclear data server which provides data in the evaluated nuclear data library through the network by means of TCP/IP. The client is not necessarily a user but a computer program. Two examples with a prototype server program are demonstrated, the first is data transfer from the server to a user, and the second is to a computer program. (author)

APLIKASI SERVER VIRTUAL IP UNTUK MIKROKONTROLER

OpenAIRE

Ashari, Ahmad

2008-01-01

Selama ini mikrokontroler yang terhubung ke satu komputer hanya dapat diakses melalui satu IP saja, padahal kebanyakan sistem operasi sekarang dapat memperjanjikan lebih dari satu IP untuk setiap komputer dalam bentuk virtual IP. Penelitian ini mengkaji pemanfaatan virtual IP dari IP aliasing pada sistem operasi Linux sebagai Server Virtual IP untuk mikrokontroler. Prinsip dasar Server Virtual IP adalah pembuatan Virtual Host pada masing-masing IP untuk memproses paket-paket data dan menerjem...

LiveBench-1: continuous benchmarking of protein structure prediction servers.

Science.gov (United States)

Bujnicki, J M; Elofsson, A; Fischer, D; Rychlewski, L

2001-02-01

We present a novel, continuous approach aimed at the large-scale assessment of the performance of available fold-recognition servers. Six popular servers were investigated: PDB-Blast, FFAS, T98-lib, GenTHREADER, 3D-PSSM, and INBGU. The assessment was conducted using as prediction targets a large number of selected protein structures released from October 1999 to April 2000. A target was selected if its sequence showed no significant similarity to any of the proteins previously available in the structural database. Overall, the servers were able to produce structurally similar models for one-half of the targets, but significantly accurate sequence-structure alignments were produced for only one-third of the targets. We further classified the targets into two sets: easy and hard. We found that all servers were able to find the correct answer for the vast majority of the easy targets if a structurally similar fold was present in the server's fold libraries. However, among the hard targets--where standard methods such as PSI-BLAST fail--the most sensitive fold-recognition servers were able to produce similar models for only 40% of the cases, half of which had a significantly accurate sequence-structure alignment. Among the hard targets, the presence of updated libraries appeared to be less critical for the ranking. An "ideally combined consensus" prediction, where the results of all servers are considered, would increase the percentage of correct assignments by 50%. Each server had a number of cases with a correct assignment, where the assignments of all the other servers were wrong. This emphasizes the benefits of considering more than one server in difficult prediction tasks. The LiveBench program (http://BioInfo.PL/LiveBench) is being continued, and all interested developers are cordially invited to join.

Getting started with SQL Server 2012 cube development

CERN Document Server

Lidberg, Simon

2013-01-01

As a practical tutorial for Analysis Services, get started with developing cubes. ""Getting Started with SQL Server 2012 Cube Development"" walks you through the basics, working with SSAS to build cubes and get them up and running.Written for SQL Server developers who have not previously worked with Analysis Services. It is assumed that you have experience with relational databases, but no prior knowledge of cube development is required. You need SQL Server 2012 in order to follow along with the exercises in this book.

MX: A beamline control system toolkit

Science.gov (United States)

Lavender, William M.

2000-06-01

The development of experimental and beamline control systems for two Collaborative Access Teams at the Advanced Photon Source has resulted in the creation of a portable data acquisition and control toolkit called MX. MX consists of a set of servers, application programs and libraries that enable the creation of command line and graphical user interface applications that may be easily retargeted to new and different kinds of motor and device controllers. The source code for MX is written in ANSI C and Tcl/Tk with interprocess communication via TCP/IP. MX is available for several versions of Unix, Windows 95/98/NT and DOS. It may be downloaded from the web site http://www.imca.aps.anl.gov/mx/.

An Electronic Healthcare Record Server Implemented in PostgreSQL

Directory of Open Access Journals (Sweden)

Tony Austin

2015-01-01

Full Text Available This paper describes the implementation of an Electronic Healthcare Record server inside a PostgreSQL relational database without dependency on any further middleware infrastructure. The five-part international standard for communicating healthcare records (ISO EN 13606 is used as the information basis for the design of the server. We describe some of the features that this standard demands that are provided by the server, and other areas where assumptions about the durability of communications or the presence of middleware lead to a poor fit. Finally, we discuss the use of the server in two real-world scenarios including a commercial application.

Client Server design and implementation issues in the Accelerator Control System environment

International Nuclear Information System (INIS)

Sathe, S.; Hoff, L.; Clifford, T.

1995-01-01

In distributed system communication software design, the Client Server model has been widely used. This paper addresses the design and implementation issues of such a model, particularly when used in Accelerator Control Systems. in designing the Client Server model one needs to decide how the services will be defined for a server, what types of messages the server will respond to, which data formats will be used for the network transactions and how the server will be located by the client. Special consideration needs to be given to error handling both on the server and client side. Since the server usually is located on a machine other than the client, easy and informative server diagnostic capability is required. The higher level abstraction provided by the Client Server model simplifies the application writing, however fine control over network parameters is essential to improve the performance. Above mentioned design issues and implementation trade-offs are discussed in this paper

Purine Restriction Induces Pronounced Translational Upregulation of the NT1 Adenosine/Pyrimidine Nucleoside Transporter in Leishmania major

OpenAIRE

Ortiz, Diana; Valdés, Raquel; Sanchez, Marco A.; Hayenga, Johanna; Elya, Carolyn; Detke, Siegfried; Landfear, Scott M.

2010-01-01

Leishmania and other parasitic protozoa are unable to synthesize purines de novo and are reliant upon purine nucleoside and nucleobase transporters to import preformed purines from their hosts. To study the roles of the four purine permeases NT1-NT4 in Leishmania major, null mutants in each transporter gene were prepared and the effect of each gene deletion on purine uptake was monitored. Deletion of the NT3 purine nucleobase transporter gene or both NT3 and the NT2 nucleoside transporter gen...

Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells.

Science.gov (United States)

Vita, N; Oury-Donat, F; Chalon, P; Guillemot, M; Kaghad, M; Bachy, A; Thurneyssen, O; Garcia, S; Poinot-Chazel, C; Casellas, P; Keane, P; Le Fur, G; Maffrand, J P; Soubrie, P; Caput, D; Ferrara, P

1998-11-06

The human levocabastine-sensitive neurotensin NT2 receptor was cloned from a cortex cDNA library and stably expressed in Chinese hamster ovary (CHO) cells in order to study its binding and signalling characteristics. The receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. It also binds levocabastine, a histamine H1 receptor antagonist that is not recognised by neurotensin NT1 receptor. Neurotensin binding to recombinant neurotensin NT2 receptor expressed in CHO cells does not elicit a biological response as determined by second messenger measurements. Levocabastine, and the peptides neuromedin N and xenin were also ineffective on neurotensin NT2 receptor activation. Experiments with the neurotensin NT1 receptor antagonists SR48692 and SR142948A, resulted in the unanticipated discovery that both molecules are potent agonists on neurotensin NT2 receptor. Both compounds, following binding to neurotensin NT2 receptor, enhance inositol phosphates (IP) formation with a subsequent [Ca2+]i mobilisation; induce arachidonic acid release; and stimulate mitogen-activated protein kinase (MAPK) activity. Interestingly, these activities are antagonised by neurotensin and levocabastine in a concentration-dependent manner. These activities suggest that the human neurotensin NT2 receptor may be of physiological importance and that a natural agonist for the receptor may exist.

Purine restriction induces pronounced translational upregulation of the NT1 adenosine/pyrimidine nucleoside transporter in Leishmania major.

Science.gov (United States)

Ortiz, Diana; Valdés, Raquel; Sanchez, Marco A; Hayenga, Johanna; Elya, Carolyn; Detke, Siegfried; Landfear, Scott M

2010-10-01

Leishmania and other parasitic protozoa are unable to synthesize purines de novo and are reliant upon purine nucleoside and nucleobase transporters to import preformed purines from their hosts. To study the roles of the four purine permeases NT1-NT4 in Leishmania major, null mutants in each transporter gene were prepared and the effect of each gene deletion on purine uptake was monitored. Deletion of the NT3 purine nucleobase transporter gene or both NT3 and the NT2 nucleoside transporter gene resulted in pronounced upregulation of adenosine and uridine uptake mediated by the NT1 permease and also induced up to a 200-fold enhancement in the level of the NT1 protein but not mRNA. A similar level of upregulation of NT1 was achieved in wild-type promastigotes that were transferred to medium deficient in purines. Pulse labelling and treatment of cells with the translation inhibitor cycloheximide revealed that control of NT1 expression occurs primarily at the level of translation and not protein turnover. These observations imply the existence of a translational control mechanism that enhances the ability of Leishmania parasites to import essential purines when they are present at limiting concentrations. © 2010 Blackwell Publishing Ltd.

The Fifteenth International Conference on the Science and Application of Nanotubes (NT14)

Energy Technology Data Exchange (ETDEWEB)

cronin, stephen

2015-01-06

The Fifteenth International Conference on the Science and Application of Nanotubes (NT14) was held at the University of Southern California in Los Angeles, California on June 2-6, 2014. NT14 upheld the NT tradition of presenting the latest results in the science and applications of nanotubes and related materials in plenary sessions. Emphasis was given to convivial poster sessions and student participation. Over 225 participants attended the conference, including students, post-docs, faculty, and members from industry. A total of 45 talks were presented, as well as 157 posters.

On a Batch Arrival Queuing System Equipped with a Stand-by Server during Vacation Periods or the Repairs Times of the Main Server

Directory of Open Access Journals (Sweden)

Rehab F. Khalaf

2011-01-01

Full Text Available We study a queuing system which is equipped with a stand-by server in addition to the main server. The stand-by server provides service to customers only during the period of absence of the main server when either the main server is on a vacation or it is in the state of repairs due to a sudden failure from time to time. The service times, vacation times, and repair times are assumed to follow general arbitrary distributions while the stand-by service times follow exponential distribution. Supplementary variables technique has been used to obtain steady state results in explicit and closed form in terms of the probability generating functions for the number of customers in the queue, the average number of customers, and the average waiting time in the queue while the MathCad software has been used to illustrate the numerical results in this work.

Níveis NT-Pro-BNP e resposta ao exercício em pacientes com fluxo lento coronariano NT-Pro-BNP levels and their response to exercise in patients with slow coronary flow

Directory of Open Access Journals (Sweden)

Mustafa Yurtdaş

2012-12-01

Full Text Available FUNDAMENTO: Os peptídeos natriuréticos são liberados pelo coração em resposta ao estresse da parede. OBJETIVO: As concentrações de NT-Pro-BNP em pacientes com Fluxo Lento Coronariano (FLC foram avaliadas antes e depois do teste de exercício e comparados com os valores dos controles saudáveis. MÉTODOS: A população do estudo foi de 34 pacientes com FLC [22 homens (64,7%, com idade 51,0 ± 6,2 anos], e 34 indivíduos normais com artérias coronarianas normais [21 homens (61,8%, com idade 53,2 ± 6,6 anos]. As taxas de fluxo coronariano dos pacientes e controles foram determinadas pelo escore TIMI Trombólise no Infarto do Miocárdio (Thrombolysis in Myocardial Infarction. As amostras de sangue foram coletadas em repouso e após o teste ergométrico. RESULTADOS: As concentrações basais de NT-Pro-BNP nos pacientes com FLC foram superiores às dos indivíduos-controle (NT-Pro-BNP: 49,7 ± 14,2 pg/mL vs. 25,3 ± 4,6 pg/mL p BACKGROUND: Natriuretic peptides are released by the heart in response to wall stress. OBJECTIVE: The NT-Pro-BNP concentrations in slow coronary flow (SCF patients were assessed before and after the exercise test and compared with the values of healthy controls. METHODS: The study population was 34 patients with SCF [22 males (64.7%, aged 51.0±6.2 years], and 34 normal subjects with normal coronary arteries [21 males (61.8%, aged 53.2±6.6 years]. Coronary flow rates of all patients and control subjects were documented as Thrombolysis in Myocardial Infarction (TIMI frame count. Blood samples were drawn at rest and after the exercise testing. RESULTS: The baseline NT-Pro-BNP concentrations of the SCF patients were higher than those of the control subjects (NT-Pro-BNP: 49.7±14.2 pg/mL vs. 25.3±4.6 pg/mL p<0.0001, respectively, and this difference increased after exercise test between the groups (NT-Pro-BNP: 69.5±18.6 pg/mL vs. 30.9±6.4 pg/mL p<0.0001. In SCF group after exercise, NT-Pro-BNP concentration in 15

Níveis NT-Pro-BNP e resposta ao exercício em pacientes com fluxo lento coronariano NT-Pro-BNP levels and their response to exercise in patients with slow coronary flow

Directory of Open Access Journals (Sweden)

Mustafa Yurtdaş

2012-01-01

Full Text Available FUNDAMENTO: Os peptídeos natriuréticos são liberados pelo coração em resposta ao estresse da parede. OBJETIVO: As concentrações de NT-Pro-BNP em pacientes com Fluxo Lento Coronariano (FLC foram avaliadas antes e depois do teste de exercício e comparados com os valores dos controles saudáveis. MÉTODOS: A população do estudo foi de 34 pacientes com FLC [22 homens (64,7%, com idade 51,0 ± 6,2 anos], e 34 indivíduos normais com artérias coronarianas normais [21 homens (61,8%, com idade 53,2 ± 6,6 anos]. As taxas de fluxo coronariano dos pacientes e controles foram determinadas pelo escore TIMI Trombólise no Infarto do Miocárdio (Thrombolysis in Myocardial Infarction. As amostras de sangue foram coletadas em repouso e após o teste ergométrico. RESULTADOS: As concentrações basais de NT-Pro-BNP nos pacientes com FLC foram superiores às dos indivíduos-controle (NT-Pro-BNP: 49,7 ± 14,2 pg/mL vs. 25,3 ± 4,6 pg/mL p BACKGROUND: Natriuretic peptides are released by the heart in response to wall stress. OBJECTIVE: The NT-Pro-BNP concentrations in slow coronary flow (SCF patients were assessed before and after the exercise test and compared with the values of healthy controls. METHODS: The study population was 34 patients with SCF [22 males (64.7%, aged 51.0±6.2 years], and 34 normal subjects with normal coronary arteries [21 males (61.8%, aged 53.2±6.6 years]. Coronary flow rates of all patients and control subjects were documented as Thrombolysis in Myocardial Infarction (TIMI frame count. Blood samples were drawn at rest and after the exercise testing. RESULTS: The baseline NT-Pro-BNP concentrations of the SCF patients were higher than those of the control subjects (NT-Pro-BNP: 49.7±14.2 pg/mL vs. 25.3±4.6 pg/mL p<0.0001, respectively, and this difference increased after exercise test between the groups (NT-Pro-BNP: 69.5±18.6 pg/mL vs. 30.9±6.4 pg/mL p<0.0001. In SCF group after exercise, NT-Pro-BNP concentration in 15

The SMARTCyp cytochrome P450 metabolism prediction server

DEFF Research Database (Denmark)

Rydberg, Patrik; Gloriam, David Erik Immanuel; Olsen, Lars

2010-01-01

The SMARTCyp server is the first web application for site of metabolism prediction of cytochrome P450-mediated drug metabolism.......The SMARTCyp server is the first web application for site of metabolism prediction of cytochrome P450-mediated drug metabolism....

Grab Windows training opportunities; check CERN Windows roadmap!

CERN Multimedia

IT Department

2011-01-01

CERN Operating Systems and Information Services group (IT-OIS) actively monitors market trends to check how new software products correspond to CERN needs. In the Windows world, Windows 7 has been a big hit, with over 1500 Windows 7 PCs within less than a year since its support was introduced at CERN. No wonder: Windows XP is nearly 10 years old and is steadily approaching the end of its life-cycle. At CERN, support for Windows XP will stop at the end of December 2012. Compared to Vista, Windows 7 has the same basic hardware requirements, but offers higher performance, so the decision to upgrade is rather straightforward. CERN support for Vista will end in June 2011. In the world of Microsoft Office, version 2007 offers better integration with the central services than the older version 2003. Progressive upgrade from 2003 to 2007 is planned to finish in September 2011, but users are encouraged to pro-actively upgrade at their convenience. Please note that Office 2007 brings an important change in the area of ...

Ultra-Sensitive NT-proBNP Quantification for Early Detection of Risk Factors Leading to Heart Failure

Directory of Open Access Journals (Sweden)

Keum-Soo Song

2017-09-01

Full Text Available Cardiovascular diseases such as acute myocardial infarction and heart failure accounted for the death of 17.5 million people (31% of all global deaths in 2015. Monitoring the level of circulating N-terminal proBNP (NT-proBNP is crucial for the detection of people at risk of heart failure. In this article, we describe a novel ultra-sensitive NT-proBNP test (us-NT-proBNP that allows the quantification of circulating NT-proBNP in 30 min at 25 °C in the linear detection range of 7.0–600 pg/mL. It is a first report on the application of a fluorescence bead labeled detection antibody, DNA-guided detection method, and glass fiber membrane platform for the quantification of NT-proBNP in clinical samples. Limit of blank, limit of detection, and limit of quantification were 2.0 pg/mL, 3.7 pg/mL, and 7 pg/mL, respectively. The coefficient of variation was found to be less than 10% in the entire detection range of 7–600 pg/mL. The test demonstrated specificity for NT-proBNP without interferences from bilirubin, intra-lipid, biotin, and hemoglobin. The serial dilution test for plasma samples containing various NT-proBNP levels showed the linear decrement in concentration with the regression coefficient of 0.980–0.998. These results indicate that us-NT-proBNP test does not suffer from the interference of the plasma components for the measurement of NT-proBNP in clinical samples.

NT-pro-BNP is an independent predictor of mortality in patients with end-stage renal disease.

Science.gov (United States)

Svensson, M; Gorst-Rasmussen, A; Schmidt, E B; Jorgensen, K A; Christensen, J H

2009-04-01

Patients with end-stage renal disease (ESRD) have an increased mortality from cardiovascular disease (CVD). N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is an independent predictor of mortality in patients with ischemic heart disease and congestive heart failure. Previous data have shown markedly elevated levels of NT-pro-BNP in patients with ESRD, while the prognostic value of elevated levels of NT-pro-BNP in patients with ESRD is largely unknown. The aim of the present study was to examine if the level of NT-pro-BNP predicts mortality in patients with ERSD and CVD. We prospectively followed 206 patients with ESRD and documented CVD. Levels of NT-pro-BNP were measured at baseline, and patients were followed for 2 years or until they reached the predefined endpoint of all-cause mortality. During follow-up, the total mortality was 44% (90/206). Patients who died were followed for a median of 314 days (interquartile range 179 - 530). Using Cox regression analysis, age, female sex, systolic blood pressure, dialysis efficiency and plasma levels of NT-pro-BNP were independent prognostic risk factors of mortality. In receiver operating characteristic curve analysis a cut off value for NT-pro-BNP was determined. Patients with values of NT-pro-BNP above 12.200 pg/ml had a 3 times higher risk of death than patients below the cut-off value (HR 3.05 95% CI 1.96 - 4.77, p pro-BNP, NT-pro-BNP is still an independent predictor of mortality and might add prognostic information in patients with ESRD and documented CVD.

Asynchronous data change notification between database server and accelerator control systems

International Nuclear Information System (INIS)

Wenge Fu; Seth Nemesure; Morris, J.

2012-01-01

Database data change notification (DCN) is a commonly used feature, it allows to be informed when the data has been changed on the server side by another client. Not all database management systems (DBMS) provide an explicit DCN mechanism. Even for those DBMS's which support DCN (such as Oracle and MS SQL server), some server side and/or client side programming may be required to make the DCN system work. This makes the setup of DCN between database server and interested clients tedious and time consuming. In accelerator control systems, there are many well established software client/server architectures (such as CDEV, EPICS, and ADO) that can be used to implement data reflection servers that transfer data asynchronously to any client using the standard SET/GET API. This paper describes a method for using such a data reflection server to set up asynchronous DCN (ADCN) between a DBMS and clients. This method works well for all DBMS systems which provide database trigger functionality. (authors)

Two Stage Secure Dynamic Load Balancing Architecture for SIP Server Clusters

Directory of Open Access Journals (Sweden)

G. Vennila

2014-08-01

Full Text Available Session Initiation Protocol (SIP is a signaling protocol emerged with an aim to enhance the IP network capabilities in terms of complex service provision. SIP server scalability with load balancing has a greater concern due to the dramatic increase in SIP service demand. Load balancing of session method (request/response and security measures optimizes the SIP server to regulate of network traffic in Voice over Internet Protocol (VoIP. Establishing a honeywall prior to the load balancer significantly reduces SIP traffic and drops inbound malicious load. In this paper, we propose Active Least Call in SIP Server (ALC_Server algorithm fulfills objectives like congestion avoidance, improved response times, throughput, resource utilization, reducing server faults, scalability and protection of SIP call from DoS attacks. From the test bed, the proposed two-tier architecture demonstrates that the ALC_Server method dynamically controls the overload and provides robust security, uniform load distribution for SIP servers.

Involvement of the putative Ca²⁺-permeable mechanosensitive channels, NtMCA1 and NtMCA2, in Ca²⁺ uptake, Ca²⁺-dependent cell proliferation and mechanical stress-induced gene expression in tobacco (Nicotiana tabacum) BY-2 cells.

Science.gov (United States)

Kurusu, Takamitsu; Yamanaka, Takuya; Nakano, Masataka; Takiguchi, Akiko; Ogasawara, Yoko; Hayashi, Teruyuki; Iida, Kazuko; Hanamata, Shigeru; Shinozaki, Kazuo; Iida, Hidetoshi; Kuchitsu, Kazuyuki

2012-07-01

To gain insight into the cellular functions of the mid1-complementing activity (MCA) family proteins, encoding putative Ca²⁺-permeable mechanosensitive channels, we isolated two MCA homologs of tobacco (Nicotiana tabacum) BY-2 cells, named NtMCA1 and NtMCA2. NtMCA1 and NtMCA2 partially complemented the lethality and Ca²⁺ uptake defects of yeast mutants lacking mechanosensitive Ca²⁺ channel components. Furthermore, in yeast cells overexpressing NtMCA1 and NtMCA2, the hypo-osmotic shock-induced Ca²⁺ influx was enhanced. Overexpression of NtMCA1 or NtMCA2 in BY-2 cells enhanced Ca²⁺ uptake, and significantly alleviated growth inhibition under Ca²⁺ limitation. NtMCA1-overexpressing BY-2 cells showed higher sensitivity to hypo-osmotic shock than control cells, and induced the expression of the touch-inducible gene, NtERF4. We found that both NtMCA1-GFP and NtMCA2-GFP were localized at the plasma membrane and its interface with the cell wall, Hechtian strands, and at the cell plate and perinuclear vesicles of dividing cells. NtMCA2 transcript levels fluctuated during the cell cycle and were highest at the G1 phase. These results suggest that NtMCA1 and NtMCA2 play roles in Ca²⁺-dependent cell proliferation and mechanical stress-induced gene expression in BY-2 cells, by regulating the Ca²⁺ influx through the plasma membrane.

Asynchronous data change notification between database server and accelerator controls system

International Nuclear Information System (INIS)

Fu, W.; Morris, J.; Nemesure, S.

2011-01-01

Database data change notification (DCN) is a commonly used feature. Not all database management systems (DBMS) provide an explicit DCN mechanism. Even for those DBMS's which support DCN (such as Oracle and MS SQL server), some server side and/or client side programming may be required to make the DCN system work. This makes the setup of DCN between database server and interested clients tedious and time consuming. In accelerator control systems, there are many well established software client/server architectures (such as CDEV, EPICS, and ADO) that can be used to implement data reflection servers that transfer data asynchronously to any client using the standard SET/GET API. This paper describes a method for using such a data reflection server to set up asynchronous DCN (ADCN) between a DBMS and clients. This method works well for all DBMS systems which provide database trigger functionality. Asynchronous data change notification (ADCN) between database server and clients can be realized by combining the use of a database trigger mechanism, which is supported by major DBMS systems, with server processes that use client/server software architectures that are familiar in the accelerator controls community (such as EPICS, CDEV or ADO). This approach makes the ADCN system easy to set up and integrate into an accelerator controls system. Several ADCN systems have been set up and used in the RHIC-AGS controls system.

Analisis Algoritma Pergantian Cache Pada Proxy Web Server Internet Dengan Simulasi

OpenAIRE

Nurwarsito, Heru

2007-01-01

Pertumbuhan jumlah client internet dari waktu ke waktu terus bertambah, maka respon akses internet menjadi semakin lambat. Untuk membantu kecepatan akses tersebut maka diperlukan cache pada Proxy Server. Penelitian ini bertujuan untuk menganalisis performansi Proxy Server pada Jaringan Internet terhadap penggunaan algoritma pergantian cache-nya.Analisis Algoritma Pergantian Cache Pada Proxy Server didesain dengan metoda pemodelan simulasi jaringan internet yang terdiri dari Web server, Proxy ...

Prognostic threshold levels of NT-proBNP testing in primary care

DEFF Research Database (Denmark)

Rosenberg, J.; Schou, M.; Gustafsson, F.

2008-01-01

AIMS: Chronic heart failure (HF) is a common condition with a poor prognosis. As delayed diagnosis and treatment of HF patients in primary care can be detrimental, risk-stratified waiting lists for echocardiography might optimize resource utilization. We investigated whether a prognostic threshold...... level of the cardiac peptide, NT-proBNP, could be identified. METHODS AND RESULTS: From 2003-2005, 5875 primary care patients with suspected HF (median age 73 years) had NT-proBNP analysed in the Copenhagen area. Eighteen percent died and 20% had a cardiovascular (CV) hospitalization (median follow....../mL) was associated with an 80% (95% CI: 20-190, P = 0.01) increased mortality risk after adjustment for age, sex, previous hospitalization, CV diseases, and chronic diseases. CONCLUSION: We identified prognostic threshold levels for mortality and CV hospitalization for NT-proBNP in primary care patients suspected...

SciServer Compute brings Analysis to Big Data in the Cloud

Science.gov (United States)

Raddick, Jordan; Medvedev, Dmitry; Lemson, Gerard; Souter, Barbara

2016-06-01

SciServer Compute uses Jupyter Notebooks running within server-side Docker containers attached to big data collections to bring advanced analysis to big data "in the cloud." SciServer Compute is a component in the SciServer Big-Data ecosystem under development at JHU, which will provide a stable, reproducible, sharable virtual research environment.SciServer builds on the popular CasJobs and SkyServer systems that made the Sloan Digital Sky Survey (SDSS) archive one of the most-used astronomical instruments. SciServer extends those systems with server-side computational capabilities and very large scratch storage space, and further extends their functions to a range of other scientific disciplines.Although big datasets like SDSS have revolutionized astronomy research, for further analysis, users are still restricted to downloading the selected data sets locally - but increasing data sizes make this local approach impractical. Instead, researchers need online tools that are co-located with data in a virtual research environment, enabling them to bring their analysis to the data.SciServer supports this using the popular Jupyter notebooks, which allow users to write their own Python and R scripts and execute them on the server with the data (extensions to Matlab and other languages are planned). We have written special-purpose libraries that enable querying the databases and other persistent datasets. Intermediate results can be stored in large scratch space (hundreds of TBs) and analyzed directly from within Python or R with state-of-the-art visualization and machine learning libraries. Users can store science-ready results in their permanent allocation on SciDrive, a Dropbox-like system for sharing and publishing files. Communication between the various components of the SciServer system is managed through SciServer‘s new Single Sign-on Portal.We have created a number of demos to illustrate the capabilities of SciServer Compute, including Python and R scripts

Solution for an Improved WEB Server

Directory of Open Access Journals (Sweden)

George PECHERLE

2009-12-01

Full Text Available We want to present a solution with maximum performance from a web server,in terms of services that the server provides. We do not always know what tools to useor how to configure what we have in order to get what we need. Keeping the Internetrelatedservices you provide in working condition can sometimes be a real challenge.And with the increasing demand in Internet services, we need to come up with solutionsto problems that occur every day.

On the single-server retrial queue

Directory of Open Access Journals (Sweden)

Djellab Natalia V.

2006-01-01

Full Text Available In this work, we review the stochastic decomposition for the number of customers in M/G/1 retrial queues with reliable server and server subjected to breakdowns which has been the subject of investigation in the literature. Using the decomposition property of M/G/1 retrial queues with breakdowns that holds under exponential assumption for retrial times as an approximation in the non-exponential case, we consider an approximate solution for the steady-state queue size distribution.

Server Interface Descriptions for Automated Testing of JavaScript Web Applications

DEFF Research Database (Denmark)

Jensen, Casper Svenning; Møller, Anders; Su, Zhendong

2013-01-01

Automated testing of JavaScript web applications is complicated by the communication with servers. Specifically, it is difficult to test the JavaScript code in isolation from the server code and database contents. We present a practical solution to this problem. First, we demonstrate that formal...... server interface descriptions are useful in automated testing of JavaScript web applications for separating the concerns of the client and the server. Second, to support the construction of server interface descriptions for existing applications, we introduce an effective inference technique that learns...... communication patterns from sample data. By incorporating interface descriptions into the testing tool Artemis, our experimental results show that we increase the level of automation for high-coverage testing on a collection of JavaScript web applications that exchange JSON data between the clients and servers...

TRAP: A Three-Way Handshake Server for TCP Connection Establishment

Directory of Open Access Journals (Sweden)

Fu-Hau Hsu

2016-11-01

Full Text Available Distributed denial of service attacks have become more and more frequent nowadays. In 2013, a massive distributed denial of service (DDoS attack was launched against Spamhaus causing the service to shut down. In this paper, we present a three-way handshaking server for Transmission Control Protocol (TCP connection redirection utilizing TCP header options. When a legitimate client attempted to connect to a server undergoing an SYN-flood DDoS attack, it will try to initiate a three-way handshake. After it has successfully established a connection, the server will reply with a reset (RST packet, in which a new server address and a secret is embedded. The client can, thus, connect to the new server that only accepts SYN packets with the corrected secret using the supplied secret.

A Fuzzy Control Course on the TED Server

DEFF Research Database (Denmark)

Dotoli, Mariagrazia; Jantzen, Jan

1999-01-01

, an educational server that serves as a learning central for students and professionals working with fuzzy logic. Through the server, TED offers an online course on fuzzy control. The course concerns automatic control of an inverted pendulum, with a focus on rule based control by means of fuzzy logic. A ball......The Training and Education Committee (TED) is a committee under ERUDIT, a Network of Excellence for fuzzy technology and uncertainty in Europe. The main objective of TED is to improve the training and educational possibilities for the nodes of ERUDIT. Since early 1999, TED has set up the TED server...

Improvements to the National Transport Code Collaboration Data Server

Science.gov (United States)

Alexander, David A.

2001-10-01

The data server of the National Transport Code Colaboration Project provides a universal network interface to interpolated or raw transport data accessible by a universal set of names. Data can be acquired from a local copy of the Iternational Multi-Tokamak (ITER) profile database as well as from TRANSP trees of MDS Plus data systems on the net. Data is provided to the user's network client via a CORBA interface, thus providing stateful data server instances, which have the advantage of remembering the desired interpolation, data set, etc. This paper will review the status and discuss the recent improvements made to the data server, such as the modularization of the data server and the addition of hdf5 and MDS Plus data file writing capability.

Openlobby: an open game server for lobby and matchmaking

Science.gov (United States)

Zamzami, E. M.; Tarigan, J. T.; Jaya, I.; Hardi, S. M.

2018-03-01

Online Multiplayer is one of the most essential feature in modern games. However, while developing a multiplayer feature can be done with a simple computer networking programming, creating a balanced multiplayer session requires more player management components such as game lobby and matchmaking system. Our objective is to develop OpenLobby, a server that available to be used by other developers to support their multiplayer application. The proposed system acts as a lobby and matchmaker where queueing players will be matched to other player according to a certain criteria defined by developer. The solution provides an application programing interface that can be used by developer to interact with the server. For testing purpose, we developed a game that uses the server as their multiplayer server.

Using Pattern Recognition Techniques for Server Overload Detection

NARCIS (Netherlands)

Bezemer, C.P.; Cheplygina, V.; Zaidman, A.

2011-01-01

One of the key factors in customer satisfaction is application performance. To be able to guarantee good performance, it is necessary to take appropriate measures before a server overload occurs. While in small systems it is usually possible to predict server overload using a subjective human

Server virtualization management of corporate network with hyper-v

OpenAIRE

Kovalenko, Taras

2012-01-01

On a paper main tasks and problems of server virtualization are considerate. Practical value of virtualization in a corporate network, advantages and disadvantages of application of server virtualization are also considerate.

Empirical Analysis of Server Consolidation and Desktop Virtualization in Cloud Computing

Directory of Open Access Journals (Sweden)

Bao Rong Chang

2013-01-01

Full Text Available Physical server transited to virtual server infrastructure (VSI and desktop device to virtual desktop infrastructure (VDI have the crucial problems of server consolidation, virtualization performance, virtual machine density, total cost of ownership (TCO, and return on investments (ROI. Besides, how to appropriately choose hypervisor for the desired server/desktop virtualization is really challenging, because a trade-off between virtualization performance and cost is a hard decision to make in the cloud. This paper introduces five hypervisors to establish the virtual environment and then gives a careful assessment based on C/P ratio that is derived from composite index, consolidation ratio, virtual machine density, TCO, and ROI. As a result, even though ESX server obtains the highest ROI and lowest TCO in server virtualization and Hyper-V R2 gains the best performance of virtual machine management; both of them however cost too much. Instead the best choice is Proxmox Virtual Environment (Proxmox VE because it not only saves the initial investment a lot to own a virtual server/desktop infrastructure, but also obtains the lowest C/P ratio.

Two-Cloud-Servers-Assisted Secure Outsourcing Multiparty Computation

Science.gov (United States)

Wen, Qiaoyan; Zhang, Hua; Jin, Zhengping; Li, Wenmin

2014-01-01

We focus on how to securely outsource computation task to the cloud and propose a secure outsourcing multiparty computation protocol on lattice-based encrypted data in two-cloud-servers scenario. Our main idea is to transform the outsourced data respectively encrypted by different users' public keys to the ones that are encrypted by the same two private keys of the two assisted servers so that it is feasible to operate on the transformed ciphertexts to compute an encrypted result following the function to be computed. In order to keep the privacy of the result, the two servers cooperatively produce a custom-made result for each user that is authorized to get the result so that all authorized users can recover the desired result while other unauthorized ones including the two servers cannot. Compared with previous research, our protocol is completely noninteractive between any users, and both of the computation and the communication complexities of each user in our solution are independent of the computing function. PMID:24982949

Improving data retrieval rates using remote data servers

International Nuclear Information System (INIS)

D'Ottavio, T.; Frak, B.; Nemesure, S.; Morris, J.

2012-01-01

The power and scope of modern Control Systems has led to an increased amount of data being collected and stored, including data collected at high (kHz) frequencies. One consequence is that users now routinely make data requests that can cause giga-bytes of data to be read and displayed. Given that a user's patience can be measured in seconds, this can be quite a technical challenge. This paper explores one possible solution to this problem - the creation of remote data servers whose performance is optimized to handle context-sensitive data requests. Methods for increasing data delivery performance include the use of high speed network connections between the stored data and the data servers, smart caching of frequently used data, and the culling of data delivered as determined by the context of the data request. This paper describes decisions made when constructing these servers and compares data retrieval performance by clients that use or do not use an intermediate data server. (authors)

Two-cloud-servers-assisted secure outsourcing multiparty computation.

Science.gov (United States)

Sun, Yi; Wen, Qiaoyan; Zhang, Yudong; Zhang, Hua; Jin, Zhengping; Li, Wenmin

2014-01-01

We focus on how to securely outsource computation task to the cloud and propose a secure outsourcing multiparty computation protocol on lattice-based encrypted data in two-cloud-servers scenario. Our main idea is to transform the outsourced data respectively encrypted by different users' public keys to the ones that are encrypted by the same two private keys of the two assisted servers so that it is feasible to operate on the transformed ciphertexts to compute an encrypted result following the function to be computed. In order to keep the privacy of the result, the two servers cooperatively produce a custom-made result for each user that is authorized to get the result so that all authorized users can recover the desired result while other unauthorized ones including the two servers cannot. Compared with previous research, our protocol is completely noninteractive between any users, and both of the computation and the communication complexities of each user in our solution are independent of the computing function.

Getting started with Oracle WebLogic Server 12c developer's guide

CERN Document Server

Nunes, Fabio Mazanatti

2013-01-01

Getting Started with Oracle WebLogic Server 12c is a fast-paced and feature-packed book, designed to get you working with Java EE 6, JDK 7 and Oracle WebLogic Server 12c straight away, so start developing your own applications.Getting Started with Oracle WebLogic Server 12c: Developer's Guide is written for developers who are just getting started, or who have some experience, with Java EE who want to learn how to develop for and use Oracle WebLogic Server. Getting Started with Oracle WebLogic Server 12c: Developer's Guide also provides a great overview of the updated features of the 12c releas

Group Policy Fundamentals, Security, and the Managed Desktop

CERN Document Server

Moskowitz, Jeremy

2010-01-01

The ultimate Group Policy guide-now updated for Windows 7 and Server 2008 R2!. IT and network administrators can streamline their Windows Server management tasks by using Group Policy tools to automate or implement rules, processes, or new security across the enterprise. In this comprehensive guide, Microsoft Group Policy MVP Jeremy Moskowitz thoroughly explores Group Policy across all Windows platforms, including the latest on Windows 7 and Server 2008 R2. If you're a Windows network administrator managing scores of users and computers, you need this essential reference on your desk.: Covers

Instant Microsoft SQL Server Analysis Services 2012 dimensions and cube

CERN Document Server

Acharya, Anurag

2013-01-01

Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. Written in a practical, friendly manner this book will take you through the journey from installing SQL Server to developing your first cubes.""Microsoft SQL Server Analysis Service 2012 Dimensions"" and Cube Starter is targeted at anyone who wants to get started with cube development in Microsoft SQL Server Analysis Services. Regardless of whether you are a SQL Server developer who knows nothing about cube development or SSAS or even OLAP, you

Window Stories

DEFF Research Database (Denmark)

Hauge, Bettina

This research project has investigated 17 households in Germany (cities and rural areas). The main aim was to learn about the significance of the window to these people: What they think of their windows, how, when and why they use them in their everyday life, if they have a favorite window and wh...

Windows 10 simplified

CERN Document Server

McFedries, Paul

2015-01-01

Learn Windows 10 quickly and painlessly with this beginner's guide Windows 10 Simplified is your absolute beginner's guide to the ins and outs of Windows. Fully updated to cover Windows 10, this highly visual guide covers all the new features in addition to the basics, giving you a one-stop resource for complete Windows 10 mastery. Every page features step-by-step screen shots and plain-English instructions that walk you through everything you need to know, no matter how new you are to Windows. You'll master the basics as you learn how to navigate the user interface, work with files, create

Windows and doors

Energy Technology Data Exchange (ETDEWEB)

1988-01-01

A complete manual is presented on windows and doors for the housing contractor. In order to understand the role of windows and doors in a house's energy performance, an introduction explains the house as a system of components that can have effects on each other. Further chapters explain in detail the parts of a window, window types and RSI values; window servicing and repair; window replacement; parts of a door, door types and RSI values; door service and repair, including weatherstripping; door replacement; and how to ensure quality, service, and customer satisfaction. A glossary of terms is included. 61 figs., 3 tabs.

Client/server approach to image capturing

Science.gov (United States)

Tuijn, Chris; Stokes, Earle

1998-01-01

The diversity of the digital image capturing devices on the market today is quite astonishing and ranges from low-cost CCD scanners to digital cameras (for both action and stand-still scenes), mid-end CCD scanners for desktop publishing and pre- press applications and high-end CCD flatbed scanners and drum- scanners with photo multiplier technology. Each device and market segment has its own specific needs which explains the diversity of the associated scanner applications. What all those applications have in common is the need to communicate with a particular device to import the digital images; after the import, additional image processing might be needed as well as color management operations. Although the specific requirements for all of these applications might differ considerably, a number of image capturing and color management facilities as well as other services are needed which can be shared. In this paper, we propose a client/server architecture for scanning and image editing applications which can be used as a common component for all these applications. One of the principal components of the scan server is the input capturing module. The specification of the input jobs is based on a generic input device model. Through this model we make abstraction of the specific scanner parameters and define the scan job definitions by a number of absolute parameters. As a result, scan job definitions will be less dependent on a particular scanner and have a more universal meaning. In this context, we also elaborate on the interaction of the generic parameters and the color characterization (i.e., the ICC profile). Other topics that are covered are the scheduling and parallel processing capabilities of the server, the image processing facilities, the interaction with the ICC engine, the communication facilities (both in-memory and over the network) and the different client architectures (stand-alone applications, TWAIN servers, plug-ins, OLE or Apple-event driven

Dynamic Web Pages: Performance Impact on Web Servers.

Science.gov (United States)

Kothari, Bhupesh; Claypool, Mark

2001-01-01

Discussion of Web servers and requests for dynamic pages focuses on experimentally measuring and analyzing the performance of the three dynamic Web page generation technologies: CGI, FastCGI, and Servlets. Develops a multivariate linear regression model and predicts Web server performance under some typical dynamic requests. (Author/LRW)

CORAL Server and CORAL Server Proxy: Scalable Access to Relational Databases from CORAL Applications

International Nuclear Information System (INIS)

Valassi, A; Kalkhof, A; Bartoldus, R; Salnikov, A; Wache, M

2011-01-01

The CORAL software is widely used at CERN by the LHC experiments to access the data they store on relational databases, such as Oracle. Two new components have recently been added to implement a model involving a middle tier 'CORAL server' deployed close to the database and a tree of 'CORAL server proxies', providing data caching and multiplexing, deployed close to the client. A first implementation of the two new components, released in the summer 2009, is now deployed in the ATLAS online system to read the data needed by the High Level Trigger, allowing the configuration of a farm of several thousand processes. This paper reviews the architecture of the software, its development status and its usage in ATLAS.

Tobacco arabinogalactan protein NtEPc can promote banana (Musa AAA) somatic embryogenesis.

Science.gov (United States)

Shu, H; Xu, L; Li, Z; Li, J; Jin, Z; Chang, S

2014-12-01

Banana is an important tropical fruit worldwide. Parthenocarpy and female sterility made it impossible to improve banana varieties through common hybridization. Genetic transformation for banana improvement is imperative. But the low rate that banana embryogenic callus was induced made the transformation cannot be performed in many laboratories. Finding ways to promote banana somatic embryogenesis is critical for banana genetic transformation. After tobacco arabinogalactan protein gene NtEPc was transformed into Escherichia coli (DE3), the recombinant protein was purified and filter-sterilized. A series of the sterilized protein was added into tissue culture medium. It was found that the number of banana immature male flowers developing embryogenic calli increased significantly in the presence of NtEPc protein compared with the effect of the control medium. Among the treatments, explants cultured on medium containing 10 mg/l of NtEPc protein had the highest chance to develop embryogenic calli. The percentage of lines that developed embryogenic calli on this medium was about 12.5 %. These demonstrated that NtEPc protein can be used to promote banana embryogenesis. This is the first paper that reported that foreign arabinogalactan protein (AGP) could be used to improve banana somatic embryogenesis.

Comparing Server Energy Use and Efficiency Using Small Sample Sizes

Energy Technology Data Exchange (ETDEWEB)

Coles, Henry C.; Qin, Yong; Price, Phillip N.

2014-11-01

This report documents a demonstration that compared the energy consumption and efficiency of a limited sample size of server-type IT equipment from different manufacturers by measuring power at the server power supply power cords. The results are specific to the equipment and methods used. However, it is hoped that those responsible for IT equipment selection can used the methods described to choose models that optimize energy use efficiency. The demonstration was conducted in a data center at Lawrence Berkeley National Laboratory in Berkeley, California. It was performed with five servers of similar mechanical and electronic specifications; three from Intel and one each from Dell and Supermicro. Server IT equipment is constructed using commodity components, server manufacturer-designed assemblies, and control systems. Server compute efficiency is constrained by the commodity component specifications and integration requirements. The design freedom, outside of the commodity component constraints, provides room for the manufacturer to offer a product with competitive efficiency that meets market needs at a compelling price. A goal of the demonstration was to compare and quantify the server efficiency for three different brands. The efficiency is defined as the average compute rate (computations per unit of time) divided by the average energy consumption rate. The research team used an industry standard benchmark software package to provide a repeatable software load to obtain the compute rate and provide a variety of power consumption levels. Energy use when the servers were in an idle state (not providing computing work) were also measured. At high server compute loads, all brands, using the same key components (processors and memory), had similar results; therefore, from these results, it could not be concluded that one brand is more efficient than the other brands. The test results show that the power consumption variability caused by the key components as a

Serum NT-proCNP levels increased after initiation of GH treatment in patients with achondroplasia/hypochondroplasia.

Science.gov (United States)

Kubota, Takuo; Wang, Wei; Miura, Kohji; Nakayama, Hirofumi; Yamamoto, Keiko; Fujiwara, Makoto; Ohata, Yasuhisa; Tachibana, Makiko; Kitaoka, Taichi; Takakuwa, Satoshi; Miyoshi, Yoko; Namba, Noriyuki; Ozono, Keiichi

2016-06-01

Serum amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) levels have been proposed as a biomarker of linear growth in healthy children. The usefulness of NT-proCNP in patients with achondroplasia (ACH)/hypochondroplasia (HCH) remains to be elucidated. The objective was to study whether serum NT-proCNP level is a good biomarker for growth in ACH/HCH and other patients of short stature. This was a longitudinal cohort study. Sixteen children with ACH (aged 0·4-4·3 years), six children with HCH (2·7-6·3 years), 23 children with idiopathic short stature (ISS) (2·2-9·0 years), eight short children with GH deficiency (GHD) (2·9-6·8 years) and five short children born small for gestational age (SGA) (2·0-6·6 years). Patients with ACH/HCH received GH treatment for 1 year. Serum NT-proCNP levels and height were measured. NT-proCNP levels positively correlated with height velocity in these short children (P < 0·05, r = 0·27). NT-proCNP levels inversely correlated with age in children with ISS alone (P < 0·01, r = -0·55). Serum NT-proCNP levels in patients with ACH/HCH were increased 3 months following the initiation of GH treatment (P < 0·05). Height SDS gain during GH treatment for 1 year was positively correlated with the changes in NT-proCNP levels after the initiation of GH (P < 0·01, r = 0·72). Serum NT-proCNP levels may be a good biomarker to indicate the effect of GH treatment on growth in patients with ACH/HCH at least in the first year and height velocity in short stature patients. © 2016 John Wiley & Sons Ltd.

NT-proBNP and diastolic left ventricular function in patients with Marfan syndrome

Directory of Open Access Journals (Sweden)

Petra Gehle

2016-09-01

Conclusions: MFS patients presenting with normal ejection fraction show disturbed diastolic function and higher NT-proBNP levels, which is partly explained by aortic Z-score. Assessment of diastolic function and NT-proBNP levels may therefore detect early abnormalities and guide surveillance and prevention management of patients with MFS.

NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure: PRIMA II Randomized Controlled Trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decompensated Heart Failure Reduce Mortality and Readmissions?).

Science.gov (United States)

Stienen, Susan; Salah, Khibar; Moons, Arno H; Bakx, Adrianus L; van Pol, Petra; Kortz, R A Mikael; Ferreira, João Pedro; Marques, Irene; Schroeder-Tanka, Jutta M; Keijer, Jan T; Bayés-Genis, Antoni; Tijssen, Jan G P; Pinto, Yigal M; Kok, Wouter E

2018-04-17

The concept of natriuretic peptide guidance has been extensively studied in patients with chronic heart failure (HF), with only limited success. The effect of NT-proBNP (N-terminal probrain natriuretic peptide)-guided therapy in patients with acute decompensated HF using a relative NT-proBNP target has not been investigated. This study aimed to assess whether NT-proBNP-guided therapy of patients with acute decompensated HF using a relative NT-proBNP target would lead to improved outcomes compared with conventional therapy. We conducted a prospective randomized controlled trial to study the impact of in-hospital guidance for acute decompensated HF treatment by a predefined NT-proBNP target (>30% reduction from admission to discharge) versus conventional treatment. Patients with acute decompensated HF with NT-proBNP levels >1700 ng/L were eligible. After achieving clinical stability, 405 patients were randomized to either NT-proBNP-guided or conventional treatment (1:1). The primary end point was dual: a composite of all-cause mortality and HF readmissions in 180 days and the number of days alive out of the hospital in 180 days. Secondary end points were all-cause mortality within 180 days, HF readmissions within 180 days, and a composite of all-cause mortality and HF readmissions within 90 days. Significantly more patients in the NT-proBNP-guided therapy group were discharged with an NT-proBNP reduction of >30% (80% versus 64%, P =0.001). Nonetheless, NT-proBNP-guided therapy did not significantly improve the combined event rate for all-cause mortality and HF readmissions (hazard ratio, 0.96; 95% confidence interval, 0.72-1.37; P =0.99) or the median number of days alive outside of the hospital (178 versus 179 days for NT-proBNP versus conventional patients, P =0.39). Guided therapy also did not significantly improve any of the secondary end points. The PRIMA II trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decompensated Heart Failure

Strength and fatigue of NT551 silicon nitride and NT551 diesel exhaust valves

Energy Technology Data Exchange (ETDEWEB)

Andrews, M.J.; Werezczak, A.A.; Kirkland, T.P.; Breder, K.

2000-02-01

The content of this report is excerpted from Mark Andrew's Ph.D. Thesis (Andrews, 1999), which was funded by a DOE/OTT High Temperature Materials Laboratory Graduate Fellowship. It involves the characterization of NT551 and valves fabricated with it. The motivations behind using silicon nitride (Si{sub 3}N{sub 4}) as an exhaust valve for a diesel engine are presented in this section. There are several economic factors that have encouraged the design and implementation of ceramic components for internal combustion (IC) engines. The reasons for selecting the diesel engine valve for this are also presented.

NT-proBNP in cardiac surgery: a new tool for the management of our patients?

Science.gov (United States)

Reyes, Guillermo; Forés, Gloria; Rodríguez-Abella, R Hugo; Cuerpo, Gregorio; Vallejo, José Luis; Romero, Carlos; Pinto, Angel

2005-06-01

Our aim was to determine NT-proBNP levels in patients undergoing cardiac surgery and if those levels are related to any of the baseline clinical characteristics of patients before surgery or any of the outcomes or events after surgery. Prospective, analytic study including 83 consecutive patients undergoing cardiac surgery. Preoperatory and postoperatory data were collected. NT-proBNP levels were measured before surgery, the day of surgery, twice the following day and every 24 h until a total of nine determinations. Venous blood was obtained by direct venipuncture and collected into serum separator tubes. Samples were centrifuged within 20 min from sampling and stored for a maximum of 12 h at 2-8 degrees C before the separation of serum. Serum was stored frozen at -40 degrees C and thawed only once at the time of analysis. Mean age was 65+/-11.8 years. An Euroscore 6 was found in 30% of patients. NYHA classification was as follows: I:27.7%; II:47%; III:25.3%. Preoperative atrial fibrilation occurred in 20.5% of patients. After surgery 18.1% of patients required inotropes. Only one death was recorded. A great variability was found in preoperative NT-proBNP levels; 759.9 (S.D.:1371.1); CI 95%: 464.9 to 1054.9 pg/ml, with a wide range (6.39-8854). Median was 366.5 pg/ml. Preoperative NT-proBNP levels were unrelated to the type of surgery (CABG vs. others), sex, age and any of the cardiovascular risk factors. NT-proBNP levels were higher in high risk patients (Euroscore 6); (P=0.021), worse NYHA class (P=0.020) and patients with preoperative atrial fibrilation (m 1767 (2205) vs m 621 (1017); P=0.001). After surgery NT-proBNP levels started increasing the following day until the fourth day (P=0.03), decreasing afterwards (P=0.019). These levels were significantly higher in patients requiring inotropes after surgery (P<0.001). We did not find any relationship between NT-proBNP levels and complications rate (P=0.59). Preoperative NT-proBNP levels depend on preoperative

Creating Large Scale Database Servers

International Nuclear Information System (INIS)

Becla, Jacek

2001-01-01

The BaBar experiment at the Stanford Linear Accelerator Center (SLAC) is designed to perform a high precision investigation of the decays of the B-meson produced from electron-positron interactions. The experiment, started in May 1999, will generate approximately 300TB/year of data for 10 years. All of the data will reside in Objectivity databases accessible via the Advanced Multi-threaded Server (AMS). To date, over 70TB of data have been placed in Objectivity/DB, making it one of the largest databases in the world. Providing access to such a large quantity of data through a database server is a daunting task. A full-scale testbed environment had to be developed to tune various software parameters and a fundamental change had to occur in the AMS architecture to allow it to scale past several hundred terabytes of data. Additionally, several protocol extensions had to be implemented to provide practical access to large quantities of data. This paper will describe the design of the database and the changes that we needed to make in the AMS for scalability reasons and how the lessons we learned would be applicable to virtually any kind of database server seeking to operate in the Petabyte region

Creating Large Scale Database Servers

Energy Technology Data Exchange (ETDEWEB)

Becla, Jacek

2001-12-14

The BaBar experiment at the Stanford Linear Accelerator Center (SLAC) is designed to perform a high precision investigation of the decays of the B-meson produced from electron-positron interactions. The experiment, started in May 1999, will generate approximately 300TB/year of data for 10 years. All of the data will reside in Objectivity databases accessible via the Advanced Multi-threaded Server (AMS). To date, over 70TB of data have been placed in Objectivity/DB, making it one of the largest databases in the world. Providing access to such a large quantity of data through a database server is a daunting task. A full-scale testbed environment had to be developed to tune various software parameters and a fundamental change had to occur in the AMS architecture to allow it to scale past several hundred terabytes of data. Additionally, several protocol extensions had to be implemented to provide practical access to large quantities of data. This paper will describe the design of the database and the changes that we needed to make in the AMS for scalability reasons and how the lessons we learned would be applicable to virtually any kind of database server seeking to operate in the Petabyte region.

ORF Alignment: NT_033777 [GENIUS II[Archive

Lifescience Database Archive (English)

Full Text Available NT_033777 gi|28571958 >1bor0 1 53 282 342 4e-04 ... ref|NP_083045.3| synoviolin 1 [Mu...s musculus] gb|AAH42199.1| Synoviolin 1 [Mus ... musculus] gb|AAH80722.1| Synoviolin 1 [Mus musculus]... ... gb|AAH57917.1| Synoviolin 1 [Mus musculus] ... Length = 61 ... Query: 280 EELRQSDNICIICREDMV

From Server to Desktop: Capital and Institutional Planning for Client/Server Technology.

Science.gov (United States)

Mullig, Richard M.; Frey, Keith W.

1994-01-01

Beginning with a request for an enhanced system for decision/strategic planning support, the University of Chicago's biological sciences division has developed a range of administrative client/server tools, instituted a capital replacement plan for desktop technology, and created a planning and staffing approach enabling rapid introduction of new…

Resources | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Links | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Efficient Windows Collaborative | Home

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

FAQ | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Glossary | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

JLABGEO: a new survey and alignment data manager

Energy Technology Data Exchange (ETDEWEB)

Tremblay, K.J.; Curtis, C.J. [Thomas Jefferson National Accelerator Facility, Virginia (United States)

1999-07-01

The Survey and Alignment group at Thomas Jefferson National Accelerator Facility has relied upon the MS-Dos program Geonet, originally developed at Stanford Linear Accelerator, as its central data manager. With the Lab decision to only use Microsoft Windows NT as the platform for PCs, limitations were reached in using Geonet. A program has been developed at Jefferson Lab, JLabGeo to mimic as many of the Geonet functions as possible, while also expanding and enhancing its capabilities. All of the adjustment programs, originally developed by Dr. Ingolf Burstedde, have been revised in order to work with arrays of any size, and operate as console applications in the NT environment. Integrating the use of a central file server as both the source of the executable programs and data files also ensures that all workstations are using the most recent data. Work continues on developing JLabGeo, notably the integration of all of our survey data types into a easily retrievable database, and the development of a central repository for beamline information and ideal coordinates. (authors)

JLABGEO: a new survey and alignment data manager

International Nuclear Information System (INIS)

Tremblay, K.J.; Curtis, C.J.

1999-01-01

The Survey and Alignment group at Thomas Jefferson National Accelerator Facility has relied upon the MS-Dos program Geonet, originally developed at Stanford Linear Accelerator, as its central data manager. With the Lab decision to only use Microsoft Windows NT as the platform for PCs, limitations were reached in using Geonet. A program has been developed at Jefferson Lab, JLabGeo to mimic as many of the Geonet functions as possible, while also expanding and enhancing its capabilities. All of the adjustment programs, originally developed by Dr. Ingolf Burstedde, have been revised in order to work with arrays of any size, and operate as console applications in the NT environment. Integrating the use of a central file server as both the source of the executable programs and data files also ensures that all workstations are using the most recent data. Work continues on developing JLabGeo, notably the integration of all of our survey data types into a easily retrievable database, and the development of a central repository for beamline information and ideal coordinates. (authors)

Improved materials management through client/server computing

International Nuclear Information System (INIS)

Brooks, D.; Neilsen, E.; Reagan, R.; Simmons, D.

1992-01-01

This paper reports that materials management and procurement impacts every organization within an electric utility from power generation to customer service. An efficient material management and procurement system can help improve productivity and minimize operating costs. It is no longer sufficient to simply automate materials management using inventory control systems. Smart companies are building centralized data warehouses and use the client/server style of computing to provide real time data access. This paper describes how Alabama Power Company, Southern Company Services and Digital Equipment Corporation transformed two existing applications, a purchase order application within DEC's ALL-IN-1 environment and a materials management application within an IBM CICS environment, into a data warehouse - client/server application. An application server is used to overcome incompatibilities between computing environments and provide easy, real-time access to information residing in multi-vendor environments

Agonist properties of a stable hexapeptide analog of neurotensin, N alpha MeArg-Lys-Pro-Trp-tLeu-Leu (NT1).

Science.gov (United States)

Akunne, H C; Demattos, S B; Whetzel, S Z; Wustrow, D J; Davis, D M; Wise, L D; Cody, W L; Pugsley, T A; Heffner, T G

1995-04-18

The major signal transduction pathway for neurotensin (NT) receptors is the G-protein-dependent stimulation of phospholipase C, leading to the mobilization of intracellular free Ca2+ ([Ca2+]i) and the stimulation of cyclic GMP. We investigated the functional actions of an analog of NT(8-13), N alpha MeArg-Lys-Pro-Trp-tLeu-Leu (NT1), and other NT related analogs by quantitative measurement of the cytosolic free Ca2+ concentration in HT-29 (human colonic adenocarcinoma) cells using the Ca(2+)-sensitive dye fura-2/AM and by effects on cyclic GMP levels in rat cerebellar slices. The NT receptor binding affinities for these analogs to HT-29 cell membranes and newborn (10-day-old) mouse brain membranes were also investigated. Data obtained from HT-29 cell and mouse brain membrane preparations showed saturable single high-affinity sites and binding densities (Bmax) of 130.2 and 87.5 fmol/mg protein, respectively. The respective KD values were 0.47 and 0.39 nM, and the Hill coefficients were 0.99 and 0.92. The low-affinity levocabastine-sensitive site was not present (K1 > 10,000) in either membrane preparation. Although the correlation of binding between HT-29 cell membranes and mouse brain membranes was quite significant (r = 0.92), some of the reference agents had lower binding affinities in the HT-29 cell membranes. The metabolically stable compound NT1 plus other NT analogs and related peptides [NT, NT(8-13), xenopsin, neuromedin N, NT(9-13), kinetensin and (D-Trp11)-NT] increased intracellular Ca2+ levels in HT-29 cells, indicating NT receptor agonist properties. The effect of NT1 in mobilizing [Ca2+]i blocked by SR 48692, a non-peptide NT antagonist. Receptor binding affinities of NT analogs to HT-29 cell membranes were positively correlated with potencies for mobilizing intracellular calcium in the same cells. In addition, NT1 increased cyclic GMP levels in rat cerebellar slices, confirming the latter findings of its NT agonist action. These results substantiate

Overexpression of NtPR-Q Up-Regulates Multiple Defense-Related Genes in Nicotiana tabacum and Enhances Plant Resistance to Ralstonia solanacearum

Directory of Open Access Journals (Sweden)

Yuanman Tang

2017-11-01

Full Text Available Various classes of plant pathogenesis-related proteins have been identified in the past several decades. PR-Q, a member of the PR3 family encoding chitinases, has played an important role in regulating plant resistance and preventing pathogen infection. In this paper, we functionally characterized NtPR-Q in tobacco plants and found that the overexpression of NtPR-Q in tobacco Yunyan87 resulted in higher resistance to Ralstonia solanacearum inoculation. Surprisingly, overexpression of NtPR-Q led to the activation of many defense-related genes, such as salicylic acid (SA-responsive genes NtPR1a/c, NtPR2 and NtCHN50, JA-responsive gene NtPR1b and ET production-associated genes NtACC Oxidase and NtEFE26. Consistent with the role of NtPR-Q in multiple stress responses, NtPR-Q transcripts were induced by the exogenous hormones SA, ethylene and methyl jasmonate, which could enhance the resistance of tobacco to R. solanacearum. Collectively, our results suggested that NtPR-Q overexpression led to the up-regulation of defense-related genes and enhanced plant resistance to R. solanacearum infection.

Microsoft SQL Server OLAP Solution - A Survey

OpenAIRE

Badiozamany, Sobhan

2010-01-01

Microsoft SQL Server 2008 offers technologies for performing On-Line Analytical Processing (OLAP), directly on data stored in data warehouses, instead of moving the data into some offline OLAP tool. This brings certain benefits, such as elimination of data copying and better integration with the DBMS compared with off-line OLAP tools. This report reviews SQL Server support for OLAP, solution architectures, tools and components involved. Standard storage options are discussed but the focus of ...

Two-Cloud-Servers-Assisted Secure Outsourcing Multiparty Computation

Directory of Open Access Journals (Sweden)

Yi Sun

2014-01-01

Full Text Available We focus on how to securely outsource computation task to the cloud and propose a secure outsourcing multiparty computation protocol on lattice-based encrypted data in two-cloud-servers scenario. Our main idea is to transform the outsourced data respectively encrypted by different users’ public keys to the ones that are encrypted by the same two private keys of the two assisted servers so that it is feasible to operate on the transformed ciphertexts to compute an encrypted result following the function to be computed. In order to keep the privacy of the result, the two servers cooperatively produce a custom-made result for each user that is authorized to get the result so that all authorized users can recover the desired result while other unauthorized ones including the two servers cannot. Compared with previous research, our protocol is completely noninteractive between any users, and both of the computation and the communication complexities of each user in our solution are independent of the computing function.

Mfold web server for nucleic acid folding and hybridization prediction.

Science.gov (United States)

Zuker, Michael

2003-07-01

The abbreviated name, 'mfold web server', describes a number of closely related software applications available on the World Wide Web (WWW) for the prediction of the secondary structure of single stranded nucleic acids. The objective of this web server is to provide easy access to RNA and DNA folding and hybridization software to the scientific community at large. By making use of universally available web GUIs (Graphical User Interfaces), the server circumvents the problem of portability of this software. Detailed output, in the form of structure plots with or without reliability information, single strand frequency plots and 'energy dot plots', are available for the folding of single sequences. A variety of 'bulk' servers give less information, but in a shorter time and for up to hundreds of sequences at once. The portal for the mfold web server is http://www.bioinfo.rpi.edu/applications/mfold. This URL will be referred to as 'MFOLDROOT'.

CERN Document Server (CDS): Introduction

CERN Multimedia

CERN. Geneva; Costa, Flavio

2017-01-01

A short online tutorial introducing the CERN Document Server (CDS). Basic functionality description, the notion of Revisions and the CDS test environment. Links: CDS Production environment CDS Test environment  

Tobacco Transcription Factor NtWRKY12 Interacts With TGA2.2 in vitro and in vivo

Directory of Open Access Journals (Sweden)

Marcel evan Verk

2011-07-01

Full Text Available The promoter of the salicylic acid-inducible PR-1a gene of Nicotiana tabacum contains binding sites for transcription factor NtWRKY12 (WK-box at position -564 and TGA factors (as-1-like element at position -592. Transactivation experiments in Arabidopsis protoplasts derived from wild type, npr1-1, tga256 and tga2356 mutant plants revealed that NtWRKY12 alone was able to induce a PR-1a::β-glucuronidase (GUS reporter gene to high levels, independent of co-expressed tobacco NtNPR1, TGA2.1, TGA2.2 or endogenous Arabidopsis NPR1, TGA2/3/5/6. By in vitro pull-down assays with GST and Strep fusion proteins and by Fluorescence Resonance Energy Transfer assays with protein-CFP and protein-YFP fusions in transfected protoplasts, it was shown that NtWRKY12 and TGA2.2 could interact in vitro and in vivo. Interaction of NtWRKY12 with TGA1a or TGA2.1 was not detectable by these techniques. A possible mechanism for the role of NtWRKY12 and TGA2.2 in PR-1a gene expression is discussed.

Dynamic modeling of the manipulator RD5NT

Directory of Open Access Journals (Sweden)

Eduardo Monteiro Aguiar

2015-05-01

Full Text Available This article presents the development of a dynamicmathematical model for the DIDACTA ITALIARD5NT manipulator. The model is intendedto be used in the development of strategies ofposition-trajectory control. The choice modelingtype aims at identifying the physical parametersof the manipulator.

Instant Hyper-v Server Virtualization starter

CERN Document Server

Eguibar, Vicente Rodriguez

2013-01-01

Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks.The approach would be in a tutorial manner that will guide the users in an orderly manner toward virtualization.This book is conceived for system administrator and advanced PC enthusiasts who want to venture into the virtualization world. Although this book goes from scratch up, knowledge on server Operative Systems, LAN and networking has to be in place. Having a good background on server administration is desirable, including networking service

Designing a scalable video-on-demand server with data sharing

Science.gov (United States)

Lim, Hyeran; Du, David H. C.

2001-01-01

As current disk space and transfer speed increase, the bandwidth between a server and its disks has become critical for video-on-demand (VOD) services. Our VOD server consists of several hosts sharing data on disks through a ring-based network. Data sharing provided by the spatial-reuse ring network between servers and disks not only increases the utilization towards full bandwidth but also improves the availability of videos. Striping and replication methods are introduced in order to improve the efficiency of our VOD server system as well as the availability of videos. We consider tow kinds of resources of a VOD server system. Given a representative access profile, our intention is to propose an algorithm to find an initial condition, place videos on disks in the system successfully. If any copy of a video cannot be placed due to lack of resources, more servers/disks are added. When all videos are place on the disks by our algorithm, the final configuration is determined with indicator of how tolerable it is against the fluctuation in demand of videos. Considering it is a NP-hard problem, our algorithm generates the final configuration with O(M log M) at best, where M is the number of movies.

Look-ahead policies for admission to a single server loss system

NARCIS (Netherlands)

Nawijn, W.M.

1990-01-01

Consider a single server loss system in which the server, being idle, may reject or accept an arriving customer for service depending on the state at the arrival epoch. It is assumed that at every arrival epoch the server knows the service time of the arriving customer, the arrival time of the next

The influence of BANXIAXIEXIN decoction and its analogous preparations on neurotensin (NT) in rat models with reflux esophagitis

International Nuclear Information System (INIS)

Liu Xiaoni; Gao Yanqing; Si Yinchu; Niu Xin

2003-01-01

Objective: To investigate the mechanism of BANXIAXIEXIN TANG Decoction and its analogous preparations in treatment of reflux esophagitis. Methods: 60 rat models with duodenogastroesophageal reflux were divided into 4 equal numbered groups; control group, BANXIAXIEXIN TANG group, SHENGJIANGXIEXIN TANG group, GANCAOXIEXIN TANG group. The contents of NT in hypothalamus, ileum and plasma were measured by radioimmunoassay in all these models and the relationship between NT concentration and degree of esophageal mucosa injury in the control group was analysed. Results: BANXIAXIEXIN Decoction and its analogous preparations could reduce the degree of the esophageal mucosa injury significantly (p<0.01). Compared with the control group: the hypothalamus content of NT in SHENGJIANGXIEXIN TANG group was significantly lowered (p<0.05), the ileum content of NT in BANXIAXIEXIN TANG group was significantly lowered (p<0.01), the plasma contents of NT in both groups were significantly lowered (p<0.05) as well. There was positive correlation (r=0.442, p<0.01) between content of NT in ileum and degree of the esophageal mucosa injury in control group. Conclusion: NT may play an important role in the development reflux esophagitis. Regulating the synthesis and secretion of NT may be one of the mechanisms of BANXIAXIEXIN Decoction and its analogus preparations in treatment of reflux esophagitis

Evaluation of NT-proBNP concentrations during exercise in asymptomatic patients with severe high-gradient aortic stenosis.

Science.gov (United States)

Dobrowolski, Piotr; Lech, Agnieszka; Klisiewicz, Anna; Hoffman, Piotr

2016-08-11

INTRODUCTION The effect of asymptomatic severe aortic stenosis (ASAS) on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels ar rest and during exercise, as well as their relevance for clinical practice remain controversial.  OBJECTIVES The aim of this study was to test the hypothesis of whether the evaluation of NT-proBNP concentrations during exercise provides additional information about the severity of aortic stenosis and left ventricular remodeling in patients with ASAS. PATIENTS AND METHODS A total of 50 patients with ASAS (mean age, 38.4 ±18.1 years) and 21 healthy subjects (mean age, 43.4 ±10.6 years) were enrolled. Rest and exercise echocardiography was performed to evaluate maximum velocity (Vmax), mean aortic gradient (AG), and aortic valve area (AVA). The left ventricular mass index (LVMI) was calculated. NT-proBNP concentrations at rest and during exercise were assessed, and the difference between the 2 values was calculated (ΔNT-proBNP). RESULTS NT-proBNP and ΔNT-proBNP levels at rest and during exercise were significantly higher in the ASAS group compared with the control group. In the ASAS group, NT-proBNP levels at rest significantly correlated with LVMI (r = 0.432; P <0.0001), AVA (r = -0.408; P <0.0001), Vmax (r = 0.375; P = 0.002), and mean AG (r = 0.257; P = 0.03). NT-proBNP levels during exercise significantly correlated with LVMI (r = 0.432; P <0.0001), mean AG (r = 0.401; P = 0.001), and AVA (r = -0.375; P = 0.001). In the multivariate logistic regression model, the factors independently associated with NT-proBNP both at rest and during exercise were age, AVA, and LVMI. CONCLUSIONS NT-proBNP levels at rest provide valuable information for identifying patients with more advanced left ventricular hypertrophy secondary to severe aortic stenosis. NT-proBNP levels during exercise do not provide new information on the severity of AS.

Distributed processing and network of data acquisition and diagnostics control for Large Helical Device (LHD)

International Nuclear Information System (INIS)

Nakanishi, H.; Kojima, M.; Hidekuma, S.

1997-11-01

The LHD (Large Helical Device) data processing system has been designed in order to deal with the huge amount of diagnostics data of 600-900 MB per 10-second short-pulse experiment. It prepares the first plasma experiment in March 1998. The recent increase of the data volume obliged to adopt the fully distributed system structure which uses multiple data transfer paths in parallel and separates all of the computer functions into clients and servers. The fundamental element installed for every diagnostic device consists of two kinds of server computers; the data acquisition PC/Windows NT and the real-time diagnostics control VME/VxWorks. To cope with diversified kinds of both device control channels and diagnostics data, the object-oriented method are utilized wholly for the development of this system. It not only reduces the development burden, but also widen the software portability and flexibility. 100Mbps EDDI-based fast networks will re-integrate the distributed server computers so that they can behave as one virtual macro-machine for users. Network methods applied for the LHD data processing system are completely based on the TCP/IP internet technology, and it provides the same accessibility to the remote collaborators as local participants can operate. (author)

HDF-EOS Web Server

Science.gov (United States)

Ullman, Richard; Bane, Bob; Yang, Jingli

2008-01-01

A shell script has been written as a means of automatically making HDF-EOS-formatted data sets available via the World Wide Web. ("HDF-EOS" and variants thereof are defined in the first of the two immediately preceding articles.) The shell script chains together some software tools developed by the Data Usability Group at Goddard Space Flight Center to perform the following actions: Extract metadata in Object Definition Language (ODL) from an HDF-EOS file, Convert the metadata from ODL to Extensible Markup Language (XML), Reformat the XML metadata into human-readable Hypertext Markup Language (HTML), Publish the HTML metadata and the original HDF-EOS file to a Web server and an Open-source Project for a Network Data Access Protocol (OPeN-DAP) server computer, and Reformat the XML metadata and submit the resulting file to the EOS Clearinghouse, which is a Web-based metadata clearinghouse that facilitates searching for, and exchange of, Earth-Science data.

Sending servers to Morocco

CERN Multimedia

Joannah Caborn Wengler

2012-01-01

Did you know that computer centres are like people? They breathe air in and out like a person, they have to be kept at the right temperature, and they can even be organ donors. As part of a regular cycle of equipment renewal, the CERN Computer Centre has just donated 161 retired servers to universities in Morocco.   Prof. Abdeslam Hoummada and CERN DG Rolf Heuer seeing off the servers on the beginning of their journey to Morocco. “Many people don’t realise, but the Computer Centre is like a living thing. You don’t just install equipment and it runs forever. We’re continually replacing machines, broken parts and improving things like the cooling.” Wayne Salter, Leader of the IT Computing Facilities Group, watches over the Computer Centre a bit like a nurse monitoring a patient’s temperature, especially since new international recommendations for computer centre environmental conditions were released. “A new international s...

Supervisory control system implemented in programmable logical controller web server

OpenAIRE

Milavec, Simon

2012-01-01

In this thesis, we study the feasibility of supervisory control and data acquisition (SCADA) system realisation in a web server of a programmable logic controller. With the introduction of Ethernet protocol to the area of process control, the more powerful programmable logic controllers obtained integrated web servers. The web server of a programmable logic controller, produced by Siemens, will also be described in this thesis. Firstly, the software and the hardware equipment used for real...

KFC Server: interactive forecasting of protein interaction hot spots.

Science.gov (United States)

Darnell, Steven J; LeGault, Laura; Mitchell, Julie C

2008-07-01

The KFC Server is a web-based implementation of the KFC (Knowledge-based FADE and Contacts) model-a machine learning approach for the prediction of binding hot spots, or the subset of residues that account for most of a protein interface's; binding free energy. The server facilitates the automated analysis of a user submitted protein-protein or protein-DNA interface and the visualization of its hot spot predictions. For each residue in the interface, the KFC Server characterizes its local structural environment, compares that environment to the environments of experimentally determined hot spots and predicts if the interface residue is a hot spot. After the computational analysis, the user can visualize the results using an interactive job viewer able to quickly highlight predicted hot spots and surrounding structural features within the protein structure. The KFC Server is accessible at http://kfc.mitchell-lab.org.

Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression.

Science.gov (United States)

Souazé, Frédérique; Dupouy, Sandra; Viardot-Foucault, Véronique; Bruyneel, Erik; Attoub, Samir; Gespach, Christian; Gompel, Anne; Forgez, Patricia

2006-06-15

Emerging evidence supports neurotensin as a trophic and antiapoptotic factor, mediating its control via the high-affinity neurotensin receptor (NT1 receptor) in several human solid tumors. In a series of 51 patients with invasive ductal breast cancers, 34% of all tumors were positive for neurotensin and 91% positive for NT1 receptor. We found a coexpression of neurotensin and NT1 receptor in a large proportion (30%) of ductal breast tumors, suggesting a contribution of the neurotensinergic signaling cascade within breast cancer progression. Functionally expressed NT1 receptor, in the highly malignant MDA-MB-231 human breast cancer cell line, coordinated a series of transforming functions, including cellular migration, invasion, induction of the matrix metalloproteinase (MMP)-9 transcripts, and MMP-9 gelatinase activity. Disruption of NT1 receptor signaling by silencing RNA or use of a specific NT1 receptor antagonist, SR48692, caused the reversion of these transforming functions and tumor growth of MDA-MB-231 cells xenografted in nude mice. Our findings support the contribution of neurotensin in human breast cancer progression and point out the utility to develop therapeutic molecules targeting neurotensin or NT1 receptor signaling cascade. These strategies would increase the range of therapeutic approaches and be beneficial for specific patients.

The design and implementation about the project of optimizing proxy servers

International Nuclear Information System (INIS)

Wu Ling; Liu Baoxu

2006-01-01

Proxy server is an important facility in the network of an organization, which play an important role in security and access control and accelerating access of Internet. This article introduces the action of proxy servers, and expounds the resolutions to optimize proxy servers at IHEP: integration, dynamic domain name resolves and data synchronization. (authors)

Rclick: a web server for comparison of RNA 3D structures.

Science.gov (United States)

Nguyen, Minh N; Verma, Chandra

2015-03-15

RNA molecules play important roles in key biological processes in the cell and are becoming attractive for developing therapeutic applications. Since the function of RNA depends on its structure and dynamics, comparing and classifying the RNA 3D structures is of crucial importance to molecular biology. In this study, we have developed Rclick, a web server that is capable of superimposing RNA 3D structures by using clique matching and 3D least-squares fitting. Our server Rclick has been benchmarked and compared with other popular servers and methods for RNA structural alignments. In most cases, Rclick alignments were better in terms of structure overlap. Our server also recognizes conformational changes between structures. For this purpose, the server produces complementary alignments to maximize the extent of detectable similarity. Various examples showcase the utility of our web server for comparison of RNA, RNA-protein complexes and RNA-ligand structures. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Adventures in the evolution of a high-bandwidth network for central servers

International Nuclear Information System (INIS)

Swartz, K.L.; Cottrell, L.; Dart, M.

1994-08-01

In a small network, clients and servers may all be connected to a single Ethernet without significant performance concerns. As the number of clients on a network grows, the necessity of splitting the network into multiple sub-networks, each with a manageable number of clients, becomes clear. Less obvious is what to do with the servers. Group file servers on subnets and multihomed servers offer only partial solutions -- many other types of servers do not lend themselves to a decentralized model, and tend to collect on another, well-connected but overloaded Ethernet. The higher speed of FDDI seems to offer an easy solution, but in practice both expense and interoperability problems render FDDI a poor choice. Ethernet switches appear to permit cheaper and more reliable networking to the servers while providing an aggregate network bandwidth greater than a simple Ethernet. This paper studies the evolution of the server networks at SLAC. Difficulties encountered in the deployment of FDDI are described, as are the tools and techniques used to characterize the traffic patterns on the server network. Performance of Ethernet, FDDI, and switched Ethernet networks is analyzed, as are reliability and maintainability issues for these alternatives. The motivations for re-designing the SLAC general server network to use a switched Ethernet instead of FDDI are described, as are the reasons for choosing FDDI for the farm and firewall networks at SLAC. Guidelines are developed which may help in making this choice for other networks

Deep Recurrent Model for Server Load and Performance Prediction in Data Center

Directory of Open Access Journals (Sweden)

Zheng Huang

2017-01-01

Full Text Available Recurrent neural network (RNN has been widely applied to many sequential tagging tasks such as natural language process (NLP and time series analysis, and it has been proved that RNN works well in those areas. In this paper, we propose using RNN with long short-term memory (LSTM units for server load and performance prediction. Classical methods for performance prediction focus on building relation between performance and time domain, which makes a lot of unrealistic hypotheses. Our model is built based on events (user requests, which is the root cause of server performance. We predict the performance of the servers using RNN-LSTM by analyzing the log of servers in data center which contains user’s access sequence. Previous work for workload prediction could not generate detailed simulated workload, which is useful in testing the working condition of servers. Our method provides a new way to reproduce user request sequence to solve this problem by using RNN-LSTM. Experiment result shows that our models get a good performance in generating load and predicting performance on the data set which has been logged in online service. We did experiments with nginx web server and mysql database server, and our methods can been easily applied to other servers in data center.

Spore Coat Architecture of Clostridium novyi-NT spores

Energy Technology Data Exchange (ETDEWEB)

Plomp, M; McCafferey, J; Cheong, I; Huang, X; Bettegowda, C; Kinzler, K; Zhou, S; Vogelstein, B; Malkin, A

2007-05-07

Spores of the anaerobic bacterium Clostridium novyi-NT are able to germinate in and destroy hypoxic regions of tumors in experimental animals. Future progress in this area will benefit from a better understanding of the germination and outgrowth processes that are essential for the tumorilytic properties of these spores. Towards this end, we have used both transmission electron microscopy and atomic force microscopy to determine the structure of dormant as well as germinating spores. We found that the spores are surrounded by an amorphous layer intertwined with honeycomb parasporal layers. Moreover, the spore coat layers had apparently self-assembled and this assembly was likely to be governed by crystal growth principles. During germination and outgrowth, the honeycomb layers as well as the underlying spore coat and undercoat layers sequentially dissolved until the vegetative cell was released. In addition to their implications for understanding the biology of C. novyi-NT, these studies document the presence of proteinaceous growth spirals in a biological organism.

Standby-Loss Elimination in Server Power Supply

Directory of Open Access Journals (Sweden)

Jong-Woo Kim

2017-07-01

Full Text Available In a server power system, a standby converter is required in order to provide the standby output, monitor the system’s status, and communicate with the server power system. Since these functions are always required, losses from the standby converter are produced even though the system operates in normal mode. For these reasons, the losses deteriorate the total efficiency of the system. In this paper, a new structure is proposed to eliminate the losses from the standby converter of a server power supply. The key feature of the proposed structure is that the main direct current (DC/DC converter substitutes all of the output power of the standby converter, and the standby converter is turned off in normal mode. With the proposed structure, the losses from the standby converter can be eliminated in normal mode, and this leads to a higher efficiency in overall load conditions. Although the structure has been proposed in the previous work, very important issues such as a steady state analysis, the transient responses, and how to control the standby converter are not discussed. This paper presents these issues further. The feasibility of the proposed structure has been verified with 400 V link voltage, 12 V/62.5 A main output, and a 12 V/2.1 A standby output server power system.

MRI-Monitored Intra-Tumoral Injection of Iron-Oxide Labeled Clostridium novyi-NT Anaerobes in Pancreatic Carcinoma Mouse Model

Science.gov (United States)

Zheng, Linfeng; Zhang, Zhuoli; Khazaie, Khashayarsha; Saha, Saurabh; Lewandowski, Robert J.; Zhang, Guixiang; Larson, Andrew C.

2014-01-01

Objectives To validate the feasibility of labeling Clostridium novyi-NT (C.novyi-NT) anaerobes with iron-oxide nanoparticles for magnetic resonance imaging (MRI) and demonstrate the potential to use MRI to visualize intra-tumoral delivery of these iron-oxide labeled C.novyi-NT during percutaneous injection procedures. Materials and Methods All studies were approved by IACUC. C.novyi-NT were labeled with hybrid iron-oxide Texas red nanoparticles. Growth of labeled and control samples were evaluated with optical density. Labeling was confirmed with confocal fluorescence and transmission electron microscopy (TEM). MRI were performed using a 7 Tesla scanner with T2*-weighted (T2*W) sequence. Contrast-to-noise ratio (CNR) measurements were performed for phantoms and signal-to-noise ratio (SNR) measurements performed in C57BL/6 mice (n = 12) with Panc02 xenografts before and after percutaneous injection of iron-oxide labeled C.novyi-NT. MRI was repeated 3 and 7 days post-injection. Hematoxylin-eosin (HE), Prussian blue and Gram staining of tumor specimens were performed for confirmation of intra-tumoral delivery. Results Iron-oxide labeling had no influence upon C.novyi-NT growth. The signal intensity (SI) within T2*W images was significantly decreased for iron-oxide labeled C.novyi-NT phantoms compared to unlabeled controls. Under confocal fluorescence microscopy, the iron-oxide labeled C.novyi-NT exhibited a uniform red fluorescence consistent with observed regions of DAPI staining and overall labeling efficiency was 100% (all DAPI stained C.novyi-NT exhibited red fluorescence). Within TEM images, a large number iron granules were observed within the iron-oxide labeled C.novyi-NT; these were not observed within unlabeled controls. Intra-procedural MRI measurements permitted in vivo visualization of the intra-tumoral distribution of iron-oxide labeled C.novyi-NT following percutaneous injection (depicted as punctate regions of SI reductions within T2*-weighted

Client-server password recovery

NARCIS (Netherlands)

Chmielewski, Ł.; Hoepman, J.H.; Rossum, P. van

2009-01-01

Human memory is not perfect - people constantly memorize new facts and forget old ones. One example is forgetting a password, a common problem raised at IT help desks. We present several protocols that allow a user to automatically recover a password from a server using partial knowledge of the

Windows 8.1 bible

CERN Document Server

Boyce, Jim; Tidrow, Rob

2014-01-01

Windows 8.1 coverage that goes above and beyond all competitors? Serving as an evolutionary update to Windows 8, Windows 8.1 provides critical changes to parts of Windows 8, such as greater customization of the interface and boot operations, return of a 'start button' that reveals apps, greater integration between the two interfaces, and updates to apps. Weighing in at nearly 1000 pages, Windows 8.1 Bible provides deeper Windows insight than any other book on the market. It's valuable for both professionals needing a guide to the nooks and crannies of Windows and regular users wanting a wide

Similar pro-NT and pro-RLX2 levels after preeclampsia and after uncomplicated pregnancy

NARCIS (Netherlands)

Zoet, G. A.(Gerbrand); van Rijn, B. B.(Bas); Rehfeldt, M. (Miriam); Franx, A. (Arie); Maas, Angela H E M

2017-01-01

OBJECTIVE: Women are at increased risk of developing cardiovascular disease (CVD) after preeclampsia. Proneurotensin 1-117 (pro-NT) and prorelaxin 2 connecting peptide (pro-RLX2) have recently emerged as potential biomarkers for CVD risk in women. We assessed pro-NT and pro-RLX2 levels in women with

Similar pro-NT and pro-RLX2 levels after preeclampsia and after uncomplicated pregnancy

NARCIS (Netherlands)

Zoet, G. A.(Gerbrand); van Rijn, B. B.(Bas); Rehfeldt, M. (Miriam); Franx, A. (Arie); Maas, Angela H E M

2017-01-01

Objective Women are at increased risk of developing cardiovascular disease (CVD) after preeclampsia. Proneurotensin 1-117 (pro-NT) and prorelaxin 2 connecting peptide (pro-RLX2) have recently emerged as potential biomarkers for CVD risk in women. We assessed pro-NT and pro-RLX2 levels in women with

Analisis Perbandingan Unjuk Kerja Sistem Penyeimbang Beban Web Server dengan HAProxy dan Pound Links

Directory of Open Access Journals (Sweden)

Dite Ardian

2013-04-01

Full Text Available The development of internet technology has many organizations that expanded service website. Initially used single web server that is accessible to everyone through the Internet, but when the number of users that access the web server is very much the traffic load to the web server and the web server anyway. It is necessary for the optimization of web servers to cope with the overload received by the web server when traffic is high. Methodology of this final project research include the study of literature, system design, and testing of the system. Methods from the literature reference books related as well as from several sources the internet. The design of this thesis uses Haproxy and Pound Links as a load balancing web server. The end of this reaserch is testing the network system, where the system will be tested this stage so as to create a web server system that is reliable and safe. The result is a web server system that can be accessed by many user simultaneously rapidly as load balancing Haproxy and Pound Links system which is set up as front-end web server performance so as to create a web server that has performance and high availability.

Conversation Threads Hidden within Email Server Logs

Science.gov (United States)

Palus, Sebastian; Kazienko, Przemysław

Email server logs contain records of all email Exchange through this server. Often we would like to analyze those emails not separately but in conversation thread, especially when we need to analyze social network extracted from those email logs. Unfortunately each mail is in different record and those record are not tided to each other in any obvious way. In this paper method for discussion threads extraction was proposed together with experiments on two different data sets - Enron and WrUT..

Microsoft® Exchange Server 2007 Administrator's Companion

CERN Document Server

Glenn, Walter; Maher, Joshua

2009-01-01

Get your mission-critical messaging and collaboration systems up and running with the essential guide to deploying and managing Exchange Server 2007, now updated for SP1. This comprehensive administrator's reference covers the full range of server and client deployments, unified communications, security features, performance optimization, troubleshooting, and disaster recovery. It also includes four chapters on security policy, tools, and techniques to help protect messaging systems from viruses, spam, and phishing. Written by expert authors Walter Glenn and Scott Lowe, this reference deliver

Hypersensitive detection and quantitation of BoNT/A by IgY antibody against substrate linear-peptide.

Directory of Open Access Journals (Sweden)

Tao Li

Full Text Available Botulinum neurotoxin A (BoNT/A, the most acutely poisonous substance to humans known, cleave its SNAP-25 substrate with high specificity. Based on the endopeptidase activity, different methods have been developed to detect BoNT/A, but most lack ideal reproducibility or sensitivity, or suffer from long-term or unwanted interferences. In this study, we developed a simple method to detect and quantitate trace amounts of botulinum neurotoxin A using the IgY antibody against a linear-peptide substrate. The effects of reaction buffer, time, and temperature were analyzed and optimized. When the optimized assay was used to detect BoNT/A, the limit of detection of the assay was 0.01 mouse LD50 (0.04 pg, and the limit of quantitation was 0.12 mouse LD50/ml (0.48 pg. The findings also showed favorable specificity of detecting BoNT/A. When used to detect BoNT/A in milk or human serum, the proposed assay exhibited good quantitative accuracy (88% < recovery < 111%; inter- and intra-assay CVs < 18%. This method of detection took less than 3 h to complete, indicating that it can be a valuable method of detecting BoNT/A in food or clinical diagnosis.

Middleware for multi-client and multi-server mobile applications

NARCIS (Netherlands)

Rocha, B.P.S.; Rezende, C.G.; Loureiro, A.A.F.

2007-01-01

With popularization of mobile computing, many developers have faced problems due to great heterogeneity of devices. To address this issue, we present in this work a middleware for multi-client and multi-server mobile applications. We assume that the middleware at the server side has no resource

CCTOP: a Consensus Constrained TOPology prediction web server.

Science.gov (United States)

Dobson, László; Reményi, István; Tusnády, Gábor E

2015-07-01

The Consensus Constrained TOPology prediction (CCTOP; http://cctop.enzim.ttk.mta.hu) server is a web-based application providing transmembrane topology prediction. In addition to utilizing 10 different state-of-the-art topology prediction methods, the CCTOP server incorporates topology information from existing experimental and computational sources available in the PDBTM, TOPDB and TOPDOM databases using the probabilistic framework of hidden Markov model. The server provides the option to precede the topology prediction with signal peptide prediction and transmembrane-globular protein discrimination. The initial result can be recalculated by (de)selecting any of the prediction methods or mapped experiments or by adding user specified constraints. CCTOP showed superior performance to existing approaches. The reliability of each prediction is also calculated, which correlates with the accuracy of the per protein topology prediction. The prediction results and the collected experimental information are visualized on the CCTOP home page and can be downloaded in XML format. Programmable access of the CCTOP server is also available, and an example of client-side script is provided. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

2MASS Catalog Server Kit Version 2.1

Science.gov (United States)

Yamauchi, C.

2013-10-01

The 2MASS Catalog Server Kit is open source software for use in easily constructing a high performance search server for important astronomical catalogs. This software utilizes the open source RDBMS PostgreSQL, therefore, any users can setup the database on their local computers by following step-by-step installation guide. The kit provides highly optimized stored functions for positional searchs similar to SDSS SkyServer. Together with these, the powerful SQL environment of PostgreSQL will meet various user's demands. We released 2MASS Catalog Server Kit version 2.1 in 2012 May, which supports the latest WISE All-Sky catalog (563,921,584 rows) and 9 major all-sky catalogs. Local databases are often indispensable for observatories with unstable or narrow-band networks or severe use, such as retrieving large numbers of records within a small period of time. This software is the best for such purposes, and increasing supported catalogs and improvements of version 2.1 can cover a wider range of applications including advanced calibration system, scientific studies using complicated SQL queries, etc. Official page: http://www.ir.isas.jaxa.jp/~cyamauch/2masskit/

Client-Server Password Recovery

NARCIS (Netherlands)

Chmielewski, L.; Hoepman, J.H.; Rossum, P. van

2009-01-01

Human memory is not perfect – people constantly memorize new facts and forget old ones. One example is forgetting a password, a common problem raised at IT help desks. We present several protocols that allow a user to automatically recover a password from a server using partial knowledge of the

In-Vivo Neutralization of Botulinum Neurotoxin Serotype E Using Rabbit Polyclonal Antibody Developed against BoNT/E Light Chain.

Science.gov (United States)

Rani, Sarita; Ponmariappan, S; Sharma, Arti; Kamboj, D V; Jain, A K

2017-01-01

Clostridium botulinum is an obligate anaerobic, Gram positive bacterium that secretes extremely toxic substances known as botulinum neurotoxins (BoNTs) that cause serious paralytic illness called botulism. Based upon the serological properties, these neurotoxin have been classified into seven serotypes designated from A to G. Due to extreme toxicity of BoNTs, these neurotoxins have been designated as category A biowarfare agents. There is no commercial neutralizing antibody available for the treatment of botulism. Hence there is an urgent need to develop therapeutic intervention for prevention and cure of botulism within short period. BoNT antiserum injection is still the effective treatment. In the present study, the recombinant light chain of BoNT/E was successfully purified in soluble form. The purified rBoNT/E LC was used for the generation of polyclonal antibody in rabbit. In order to find out the neutralizing capacity of generated antisera, rabbit antiserum was incubated with 20 LD50 of botulinum neurotoxin type E for 1 hour at 37°C and then injected intraperitoneally (IP) into mice. Further in another set of experiments antiserum was administered in different ways that included administration of - antiserum and BoNT/E toxin simultaneously without preincubation, one after another at the same and different time points for its therapeutic ability. To find out cross neutralization capacity, rBoNT/E LC antiserum was pre-incubated with 5 LD50 of BoNT/A, BoNT/B, BoNT/F and then injected (IP) into mice. In all the cases mice were observed continuously for 96 hours. The results clearly indicate that developed polyclonal rabbit antiserum showed serotype specific neutralization of BoNT/E toxin only but not of BoNT/A, BoNT/B and BoNT/F. The developed antibodies will be used for preventive and therapeutic intervention of type 'E' botulism. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

The Difference Between Using Proxy Server and VPN

Directory of Open Access Journals (Sweden)

David Dwiputra Kurniadi

2015-11-01

For example, looking for software, game through internet. But sometimes, there are some websites that cannot be opened as they have Internet Positive notificatio. To solve that problem, hacker found the solution by creating Proxy Server or VPN. In this time internet is very modern and very easy to access and there are a lot of Proxy Server and VPN that can be easly used.

DoS attacks targeting SIP server and improvements of robustness

OpenAIRE

Vozňák, Miroslav; Šafařík, Jakub

2012-01-01

The paper describes the vulnerability of SIP servers to DoS attacks and methods for server protection. For each attack, this paper describes their impact on a SIP server, evaluation of the threat and the way in which they are executed. Attacks are described in detail, and a security precaution is made to prevent each of them. The proposed solution of the protection is based on a specific topology of an intrusion protection systems components consisting of a combination of...

Optimal Configuration of Fault-Tolerance Parameters for Distributed Server Access

DEFF Research Database (Denmark)

Daidone, Alessandro; Renier, Thibault; Bondavalli, Andrea

2013-01-01

Server replication is a common fault-tolerance strategy to improve transaction dependability for services in communications networks. In distributed architectures, fault-diagnosis and recovery are implemented via the interaction of the server replicas with the clients and other entities...... model using stochastic activity networks (SAN) for the evaluation of performance and dependability metrics of a generic transaction-based service implemented on a distributed replication architecture. The composite SAN model can be easily adapted to a wide range of client-server applications deployed...

An Array Library for Microsoft SQL Server with Astrophysical Applications

Science.gov (United States)

Dobos, L.; Szalay, A. S.; Blakeley, J.; Falck, B.; Budavári, T.; Csabai, I.

2012-09-01

Today's scientific simulations produce output on the 10-100 TB scale. This unprecedented amount of data requires data handling techniques that are beyond what is used for ordinary files. Relational database systems have been successfully used to store and process scientific data, but the new requirements constantly generate new challenges. Moving terabytes of data among servers on a timely basis is a tough problem, even with the newest high-throughput networks. Thus, moving the computations as close to the data as possible and minimizing the client-server overhead are absolutely necessary. At least data subsetting and preprocessing have to be done inside the server process. Out of the box commercial database systems perform very well in scientific applications from the prospective of data storage optimization, data retrieval, and memory management but lack basic functionality like handling scientific data structures or enabling advanced math inside the database server. The most important gap in Microsoft SQL Server is the lack of a native array data type. Fortunately, the technology exists to extend the database server with custom-written code that enables us to address these problems. We present the prototype of a custom-built extension to Microsoft SQL Server that adds array handling functionality to the database system. With our Array Library, fix-sized arrays of all basic numeric data types can be created and manipulated efficiently. Also, the library is designed to be able to be seamlessly integrated with the most common math libraries, such as BLAS, LAPACK, FFTW, etc. With the help of these libraries, complex operations, such as matrix inversions or Fourier transformations, can be done on-the-fly, from SQL code, inside the database server process. We are currently testing the prototype with two different scientific data sets: The Indra cosmological simulation will use it to store particle and density data from N-body simulations, and the Milky Way Laboratory

Overexpression of NtWRKY50 Increases Resistance to Ralstonia solanacearum and Alters Salicylic Acid and Jasmonic Acid Production in Tobacco.

Science.gov (United States)

Liu, Qiuping; Liu, Ying; Tang, Yuanman; Chen, Juanni; Ding, Wei

2017-01-01

WRKY transcription factors (TFs) modulate plant responses to biotic and abiotic stresses. Here, we characterized a WRKY IIc TF, NtWRKY50, isolated from tobacco ( Nicotiana tabacum ) plants. The results showed that NtWRKY50 is a nuclear-localized protein and that its gene transcript is induced in tobacco when inoculated with the pathogenic bacterium Ralstonia solanacearum . Overexpression of NtWRKY50 enhanced bacterial resistance, which correlated with enhanced SA and JA/ET signaling genes. However, silencing of the NtWRKY50 gene had no obvious effects on plant disease resistance, implying functional redundancy of NtWRKY50 with other TFs. In addition, it was found that NtWRKY50 can be induced by various biotic or abiotic stresses, such as Potato virus Y, Rhizoctonia solani, Phytophthora parasitica , hydrogen peroxide, heat, cold, and wounding as well as the hormones salicylic acid (SA), jasmonic acid (JA), and ethylene (ET). Importantly, additional analysis suggests that NtWRKY50 overexpression markedly promotes SA levels but prevents pathogen-induced JA production. These data indicate that NtWRKY50 overexpression leads to altered SA and JA content, increased expression of defense-related genes and enhanced plant resistance to R. solanacearum. These probably due to increased activity of endogenous NtWRKY50 gene or could be gain-of-function phenotypes by altering the profile of genes affected by NtWRKY50 .

NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis

DEFF Research Database (Denmark)

Reinhard, Henrik; Wiinberg, Niels; Hansen, Peter R

2011-01-01

Intensive multifactorial treatment aimed at cardiovascular (CV) risk factor reduction in type 2 diabetic patients with microalbuminuria can diminish fatal and non-fatal CV. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the utility of P-NT-proBNP in screening for ath......-media thickness (CIMT)>0.90 mm, ankle-brachial index...

Implementasi Cloud Computing Menggunakan Metode Pengembangan Sistem Agile

Directory of Open Access Journals (Sweden)

Much Aziz Muslim

2015-05-01

Full Text Available Cloud computing merupakan sebuah teknologi yang menyediakan layanan terhadap sumber daya komputasi melalui sebuah jaringan. Sumber daya yang di sediakan di dalam cloud computing meliputi mesin, media penyimpanan data, sistem operasi dan program aplikasi. Fitur dari cloud computing dipercaya akan jauh lebih hemat dan memuaskan. Masalah yang muncul adalah bagaimana mengimplementasi Cloud Computing dengan menggunakan Windows Azure Pack dan bagaimana provisioning Windows Azure Pack SQL Database. Fokus pada penelitian ini adalah pada proses deploying dan provisioning SQL Database Server. Pengimplementasian cloud computing menggunakan metode pengembangan sistem agile dengan langkah-langkah meliputi perencanaan, implementasi, pengujian (test, dokumentasi, deployment dan pemeliharaan. Untuk menjalankan proses tersebut kebutuhan perangkat yang dipersiapkan meliputi perangkat keras seperti PC Server Cisco UCS C240 M3S2, Hardisk 8753 GB, 256 GB RAM, bandwith minimal 1 Mbps dan kebutuhan perangkat lunak meliputi Windows Server 2012 R2, VMM, Windows Azure Pack, IIS, SQL Server 2012 dan Web Patform Installer. Hasil dari implementasi cloud computing menggunakan metode pengembangan sistem agile adalah terbentuknya sebuah sistem cloud hosting provider dengan menggunakan Windows Azure Pack dan SQL Server 2012 sebagai sistem utama dan pengelolaan database menggunakan Microsoft SQL Server Management 

The SAMGrid database server component: its upgraded infrastructure and future development path

International Nuclear Information System (INIS)

Loebel-Carpenter, L.; White, S.; Baranovski, A.; Garzoglio, G.; Herber, R.; Illingworth, R.; Kennedy, R.; Kreymer, A.; Kumar, A.; Lueking, L.; Lyon, A.; Merritt, W.; Terekhov, I.; Trumbo, J.; Veseli, S.; Burgon-Lyon, M.; St Denis, R.; Belforte, S.; Kerzel, U.; Bartsch, V.; Leslie, M.

2004-01-01

The SAMGrid Database Server encapsulates several important services, such as accessing file metadata and replica catalog, keeping track of the processing information, as well as providing the runtime support for SAMGrid station services. Recent deployment of the SAMGrid system for CDF has resulted in unification of the database schema used by CDF and D0, and the complexity of changes required for the unified metadata catalog has warranted a complete redesign of the DB Server. We describe here the architecture and features of the new server. In particular, we discuss the new CORBA infrastructure that utilizes python wrapper classes around IDL structs and exceptions. Such infrastructure allows us to use the same code on both server and client sides, which in turn results in significantly improved code maintainability and easier development. We also discuss future integration of the new server with an SBIR II project which is directed toward allowing the DB Server to access distributed databases, implemented in different DB systems and possibly using different schema

Note on a tandem queue with delayed server release

NARCIS (Netherlands)

Nawijn, W.M.

2000-01-01

We consider a tandem queue with two stations. The first station is an $s$-server queue with Poisson arrivals and exponential service times. After terminating his service in the first station, a customer enters the second station to require service at a single server, while in the meantime he is

A tandem queue with server slow-down and blocking

NARCIS (Netherlands)

van Foreest, N.D.; van Ommeren, Jan C.W.; Mandjes, M.R.H.; Scheinhardt, Willem R.W.

2005-01-01

We consider two variants of a two-station tandem network with blocking. In both variants the first server ceases to work when the queue length at the second station hits a 'blocking threshold.' In addition, in variant 2 the first server decreases its service rate when the second queue exceeds a

A tandem queue with server slow-down and blocking.

NARCIS (Netherlands)

van Foreest, N.; van Ommeren, J.C.; Mandjes, M.R.H.; Scheinhardt, W.

2005-01-01

We consider two variants of a two-station tandem network with blocking. In both variants the first server ceases to work when the queue length at the second station hits a 'blocking threshold.' In addition, in variant 2 the first server decreases its service rate when the second queue exceeds a

Secure Server Login by Using Third Party and Chaotic System

Science.gov (United States)

Abdulatif, Firas A.; zuhiar, Maan

2018-05-01

Server is popular among all companies and it used by most of them but due to the security threat on the server make this companies are concerned when using it so that in this paper we will design a secure system based on one time password and third parity authentication (smart phone). The proposed system make security to the login process of server by using one time password to authenticate person how have permission to login and third parity device (smart phone) as other level of security.

MultiSETTER: web server for multiple RNA structure comparison.

Science.gov (United States)

Čech, Petr; Hoksza, David; Svozil, Daniel

2015-08-12

Understanding the architecture and function of RNA molecules requires methods for comparing and analyzing their tertiary and quaternary structures. While structural superposition of short RNAs is achievable in a reasonable time, large structures represent much bigger challenge. Therefore, we have developed a fast and accurate algorithm for RNA pairwise structure superposition called SETTER and implemented it in the SETTER web server. However, though biological relationships can be inferred by a pairwise structure alignment, key features preserved by evolution can be identified only from a multiple structure alignment. Thus, we extended the SETTER algorithm to the alignment of multiple RNA structures and developed the MultiSETTER algorithm. In this paper, we present the updated version of the SETTER web server that implements a user friendly interface to the MultiSETTER algorithm. The server accepts RNA structures either as the list of PDB IDs or as user-defined PDB files. After the superposition is computed, structures are visualized in 3D and several reports and statistics are generated. To the best of our knowledge, the MultiSETTER web server is the first publicly available tool for a multiple RNA structure alignment. The MultiSETTER server offers the visual inspection of an alignment in 3D space which may reveal structural and functional relationships not captured by other multiple alignment methods based either on a sequence or on secondary structure motifs.

Advancing the Power and Utility of Server-Side Aggregation

Science.gov (United States)

Fulker, Dave; Gallagher, James

2016-01-01

During the upcoming Summer 2016 meeting of the ESIP Federation (July 19-22), OpenDAP will hold a Developers and Users Workshop. While a broad set of topics will be covered, a key focus is capitalizing on recent EOSDIS-sponsored advances in Hyrax, OPeNDAPs own software for server-side realization of the DAP2 and DAP4 protocols. These Hyrax advances are as important to data users as to data providers, and the workshop will include hands-on experiences of value to both. Specifically, a balanced set of presentations and hands-on tutorials will address advances in1.server installation,2.server configuration,3.Hyrax aggregation capabilities,4.support for data-access from clients that are HTTP-based, JSON-based or OGC-compliant (especially WCS and WMS),5.support for DAP4,6.use and extension of server-side computational capabilities, and7.several performance-affecting matters.Topics 2 through 7 will be relevant to data consumers, data providers andnotably, due to the open-source nature of all OPeNDAP softwareto developers wishing to extend Hyrax, to build compatible clients and servers, andor to employ Hyrax as middleware that enables interoperability across a variety of end-user and source-data contexts. A session for contributed talks will elaborate the topics listed above and embrace additional ones.

Design of SIP transformation server for efficient media negotiation

Science.gov (United States)

Pack, Sangheon; Paik, Eun Kyoung; Choi, Yanghee

2001-07-01

Voice over IP (VoIP) is one of the advanced services supported by the next generation mobile communication. VoIP should support various media formats and terminals existing together. This heterogeneous environment may prevent diverse users from establishing VoIP sessions among them. To solve the problem an efficient media negotiation mechanism is required. In this paper, we propose the efficient media negotiation architecture using the transformation server and the Intelligent Location Server (ILS). The transformation server is an extended Session Initiation Protocol (SIP) proxy server. It can modify an unacceptable session INVITE message into an acceptable one using the ILS. The ILS is a directory server based on the Lightweight Directory Access Protocol (LDAP) that keeps userí*s location information and available media information. The proposed architecture can eliminate an unnecessary response and re-INVITE messages of the standard SIP architecture. It takes only 1.5 round trip times to negotiate two different media types while the standard media negotiation mechanism takes 2.5 round trip times. The extra processing time in message handling is negligible in comparison to the reduced round trip time. The experimental results show that the session setup time in the proposed architecture is less than the setup time in the standard SIP. These results verify that the proposed media negotiation mechanism is more efficient in solving diversity problems.

Random mutagenesis of BoNT/E Hc nanobody to construct a secondary phage-display library.

Science.gov (United States)

Shahi, B; Mousavi Gargari, S L; Rasooli, I; Rajabi Bazl, M; Hoseinpoor, R

2014-08-01

To construct secondary mutant phage-display library of recombinant single variable domain (VHH) against botulinum neurotoxin E by error-prone PCR. The gene coding for specific VHH derived from the camel immunized with binding domain of botulinum neurotoxin E (BoNT/E) was amplified by error-prone PCR. Several biopanning rounds were used to screen the phage-displaying BoNT/E Hc nanobodies. The final nanobody, SHMR4, with increased affinity recognized BoNT/E toxin with no cross-reactivity with other antigens especially with related BoNT toxins. The constructed nanobody could be a suitable candidate for VHH-based biosensor production to detect the Clostridium botulinum type E. Diagnosis and treatment of botulinum neurotoxins are important. Generation of high-affinity antibodies based on the construction of secondary libraries using affinity maturation step leads to the development of reagents for precise diagnosis and therapy. © 2014 The Society for Applied Microbiology.

The nT1 translocation separates vulval regulatory elements from the egl-18 and elt-6 GATA factor genes.

Science.gov (United States)

Koh, Kyunghee; Bernstein, Yelena; Sundaram, Meera V

2004-03-01

egl-18 and elt-6 are partially redundant, adjacent genes encoding GATA factors essential for viability, seam cell development, and vulval development in Caenorhabditis elegans. The nT1 reciprocal translocation causes a strong Vulvaless phenotype, and an nT1 breakpoint was previously mapped to the left arm of LGIV, where egl-18/elt-6 are located. Here we present evidence that the nT1 vulval phenotype is due to a disruption of egl-18/elt-6 function specifically in the vulva. egl-18 mutations do not complement nT1 for vulval defects, and the nT1 breakpoint on LGIV is located within approximately 800 bp upstream of a potential transcriptional start site of egl-18. In addition, we have identified a approximately 350-bp cis-regulatory region sufficient for vulval expression just upstream of the nT1 breakpoint. By examining the fusion state and division patterns of the cells in the developing vulva of nT1 mutants, we demonstrate that egl-18/elt-6 prevent fusion and promote cell proliferation at multiple steps of vulval development.

Saving Money and Time with Virtual Server

CERN Document Server

Sanders, Chris

2006-01-01

Microsoft Virtual Server 2005 consistently proves to be worth its weight in gold, with new implementations thought up every day. With this product now a free download from Microsoft, scores of new users are able to experience what the power of virtualization can do for their networks. This guide is aimed at network administrators who are interested in ways that Virtual Server 2005 can be implemented in their organizations in order to save money and increase network productivity. It contains information on setting up a virtual network, virtual consolidation, virtual security, virtual honeypo

Efficient Windows Collaborative

Energy Technology Data Exchange (ETDEWEB)

Nils Petermann

2010-02-28

The project goals covered both the residential and commercial windows markets and involved a range of audiences such as window manufacturers, builders, homeowners, design professionals, utilities, and public agencies. Essential goals included: (1) Creation of 'Master Toolkits' of information that integrate diverse tools, rating systems, and incentive programs, customized for key audiences such as window manufacturers, design professionals, and utility programs. (2) Delivery of education and outreach programs to multiple audiences through conference presentations, publication of articles for builders and other industry professionals, and targeted dissemination of efficient window curricula to professionals and students. (3) Design and implementation of mechanisms to encourage and track sales of more efficient products through the existing Window Products Database as an incentive for manufacturers to improve products and participate in programs such as NFRC and ENERGY STAR. (4) Development of utility incentive programs to promote more efficient residential and commercial windows. Partnership with regional and local entities on the development of programs and customized information to move the market toward the highest performing products. An overarching project goal was to ensure that different audiences adopt and use the developed information, design and promotion tools and thus increase the market penetration of energy efficient fenestration products. In particular, a crucial success criterion was to move gas and electric utilities to increase the promotion of energy efficient windows through demand side management programs as an important step toward increasing the market share of energy efficient windows.

LHCb: Fabric Management with Diskless Servers and Quattor on LHCb

CERN Multimedia

Schweitzer, P; Brarda, L; Neufeld, N

2011-01-01

Large scientific experiments nowadays very often are using large computer farms to process the events acquired from the detectors. In LHCb a small sysadmin team manages 1400 servers of the LHCb Event Filter Farm, but also a wide variety of control servers for the detector electronics and infrastructure computers: file servers, gateways, DNS, DHCP and others. This variety of servers could not be handled without a solid fabric management system. We choose the Quattor toolkit for this task. We will present our use of this toolkit, with an emphasis on how we handle our diskless nodes (Event filter farm nodes and computers embedded in the acquisition electronic cards). We will show our current tests to replace the standard (RedHat/Scientific Linux) way of handling diskless nodes to fusion filesystems and how it improves fabric management.

Upgrading a TEXTOR Data Acquisition system for remote participation using Java and Corba

International Nuclear Information System (INIS)

Korten, M.; Becks, B.; Blom, H.; Busch, P.; Kemmerling, G.; Kooijman, W.; Krom, J.G.; Laat, C.T.A.M. de; Lourens, W.; Meer, E. van der; Nideroest, B.; Oomens, A.A.M.; Wijnoltz, F.; Samm, U.

2000-01-01

The partners in the Trilateral Euregio Cluster (TEC) are implementing and developing Remote Participation technologies that are expected to support a joint research programme on the experimental facility TEXTOR-94. A common TEC architecture for our heterogeneous data acquisition and storage systems is seen to be one of the major issues. As a consequence, legacy systems will be affected and have to be upgraded for optimised wide area network communication, platform independent data access and display. The object oriented redesign of the system to be described follows theses guidelines. The architecture of the system under development uses Java as programming environment and CORBA as Client/Server communication standard. It is described in this paper, how an operational Data Acquisition CAMAC subsystem of TEXTOR-94 based on OpenVMS and Decnet communications could be redesigned into an open, object oriented architecture in a platform independent way. A suitable Web Browser is required on the client side without further installation of application software to run the server. CORBA static method invocations are used for the communication between the client and server. At the server side, there is only Java code on top of the existing commercial OpenVMS CAMAC device driver. A modular object oriented software design permitted to eliminate dependencies of the generic module levels from the underlying bus systems. Porting of the Java code to other platforms like Windows NT and Linux has proven to be successful

Microsoft SQL Server 2012 Business Intelligence ja sen tuomat uudistukset

OpenAIRE

Luoma, Lauri

2013-01-01

Insinöörityö käsittelee Metropolia Ammattikorkeakoulun Microsoft Business Intelligence (BI) ratkaisut -kurssilla käytetyn laboratoriomanuaalin MCTS Self-Paced Training Kit (Exam 70-448) -harjoituksien siirtämistä SQL Serverille 2012. Työllä on tarkoitus osoittaa, että SQL Server 2012 BI -työkalut soveltuvat harjoituksiin. Työssä siirrytään käyttämään uudempaa työkalua, SQL Server Data Toolsia, joka korvaa SQL Server 2008 R2 Business Intelligence Development Studion. Työn alussa tutust...

Energy Servers Deliver Clean, Affordable Power

Science.gov (United States)

2010-01-01

K.R. Sridhar developed a fuel cell device for Ames Research Center, that could use solar power to split water into oxygen for breathing and hydrogen for fuel on Mars. Sridhar saw the potential of the technology, when reversed, to create clean energy on Earth. He founded Bloom Energy, of Sunnyvale, California, to advance the technology. Today, the Bloom Energy Server is providing cost-effective, environmentally friendly energy to a host of companies such as eBay, Google, and The Coca-Cola Company. Bloom's NASA-derived Energy Servers generate energy that is about 67-percent cleaner than a typical coal-fired power plant when using fossil fuels and 100-percent cleaner with renewable fuels.

RNAiFold: a web server for RNA inverse folding and molecular design.

Science.gov (United States)

Garcia-Martin, Juan Antonio; Clote, Peter; Dotu, Ivan

2013-07-01

Synthetic biology and nanotechnology are poised to make revolutionary contributions to the 21st century. In this article, we describe a new web server to support in silico RNA molecular design. Given an input target RNA secondary structure, together with optional constraints, such as requiring GC-content to lie within a certain range, requiring the number of strong (GC), weak (AU) and wobble (GU) base pairs to lie in a certain range, the RNAiFold web server determines one or more RNA sequences, whose minimum free-energy secondary structure is the target structure. RNAiFold provides access to two servers: RNA-CPdesign, which applies constraint programming, and RNA-LNSdesign, which applies the large neighborhood search heuristic; hence, it is suitable for larger input structures. Both servers can also solve the RNA inverse hybridization problem, i.e. given a representation of the desired hybridization structure, RNAiFold returns two sequences, whose minimum free-energy hybridization is the input target structure. The web server is publicly accessible at http://bioinformatics.bc.edu/clotelab/RNAiFold, which provides access to two specialized servers: RNA-CPdesign and RNA-LNSdesign. Source code for the underlying algorithms, implemented in COMET and supported on linux, can be downloaded at the server website.

Physics capabilities of the second stage Baikal detector NT-200

International Nuclear Information System (INIS)

Spiering, C.; Heller, R.; Heukenkamp, H.; Krabi, J.; Mikolajski, T.; Thon, T.; Wischnewski, R.; Alatin, S.D.; Fialkovsky, S.V.; Kulepov, V.F.; Milenin, M.B.; Belolaptikov, I.A.; Bezrukov, L.B.; Borisovets, B.A.; Bugaev, E.V.; Djilkibaev, Zh.A.M.; Domogatsky, G.V.; Donskich, L.A.; Doroshenko, A.A.; Galperin, M.D.; Gushtan, M.N.; Klabukov, A.M.; Klimushin, S.I.; Lanin, O.J.; Lubsandorzhiev, B.K.; Ogievietzky, N.V.; Panfilov, A.I.; Sokalsky, I.A.; Trofimenko, I.I.; Budnev, N.M.; Chensky, A.G.; Dobrynin, V.I.; Gress, O.A.; Koshechkin, A.P.; Lanin, J.B.; Litunenko, G.A.; Lopin, A.L.; Naumov, V.A.; Nemchenko, M.I.; Parfenov, Yu.V.; Pavlov, A.A.; Pokalev, O.P.; Primin, V.A.; Sumanov, A.A.; Tarashansky, V.A.; Zurbanov, V.L.; Dudkin, G.N.; Egorov, V.Yu.; Lukanin, A.A.; Ovcharov, A.M.; Padalko, V.M.; Padusenko, A.H.; Golikov, A.V.; Kabikov, V.B.; Kuzmichov, L.A.; Osipova, E.A.; Zaslavskaya, E.S.; Jenek, L.; Kiss, D.; Tanko, L.; Kusner, Yu.S.; Poleschuk, V.A.; Sherstyankin, P.P.; Levin, A.A.; Nikiforov, A.I.; Rosanov, M.I.

1991-12-01

We describe the lake Baikal deep underwater detector 'NT-200' and discuss its physics capabilities to investigate problems in the field of neutrino astrophysics, cosmic ray physics and particle physics. (orig.)

Windows 10 for dummies

CERN Document Server

Rathbone, Andy

2015-01-01

The fast and easy way to get up and running with Windows 10 Windows 10 For Dummies covers the latest version of Windows and gets you up and running with the changes and new features you'll find in this updated operating system. Packed with time-saving tips to help you get the most out of the software, this helpful Windows 10 guide shows you how to manage Windows tasks like navigating the interface with a mouse or touchscreen, connecting to the web, and troubleshooting problems and making quick fixes. Assuming no prior knowledge of the software, Windows 10 For Dummies addresses the updates to

Biological profile of 99mTc-HYNIC-βAla-NT(8-13) in MDAMB-231 breast cancer cell line

International Nuclear Information System (INIS)

Teodoro, Rodrigo; Faintuch, Bluma L.; Wiecek, Danielle P.; Silva, Natanael G.; Vallejo, Natalia M.

2009-01-01

Introduction: Neurotensin (NT) is a tridecapeptide involved in several growth-steps of human cancers. Recent studies postulated the role of NT and NT-receptor subtype 1 in breast cancer progression. However, the main drawback of natural NT is its rapid degradation in plasma. In an effort to develop a NT peptide-based radiopharmaceutical for the detection of breast cancer, the aim of this study was the radiolabeling of the double stabilized NT(8-13) peptide using HYNIC as chelating agent. Methods: Conjugated HYNIC-βAla-NT(8-13) was labeled with 99m Tc using tricine and EDDA as coligands. Radiochemical purity was checked by TLC and confirmed by RP-HPLC. 99m Tc-HYNIC-βAla-NT(8-13) (0.1 mL/74 MBq) was administered in Nude mice bearing MDA-MB-231 breast cancer cells and biodistribution studies were carried out at 30 and 90 min postinjection (pi). Blocking evaluation was also conducted by co-injection of 115 nmol of cold NT (8-13) analog. Planar gamma-camera imaging was acquired at the earlier time point studied. Results: Radiochemical purity of the radioconjugate was higher than 99%. Biodistribution studies revealed a very fast accumulation in tumor (1.97±0.18% ID/g, 30 min pi) with a sharply decrease at the later time point studied (0.44±0.02% ID/g). The specificity of the radioconjugate was evaluated with blockade studies. A reduction of 45.94%, 27.73% and 36.39% was found for tumor, large and small intestines, respectively, at 30 min pi. Otherwise, a less impressive blockade was observed for tumor and small intestine (28.68% and 24.90%, respectively) at the later time point studied. Conclusion: The results provide encouraging evidence in the development of radiolabeled NT(8-13) analogues for breast cancer diagnosis. (author)

Provide Views | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Reduced Fading | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

EWC Members | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Visible Transmittance | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Gas Fills | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

EWC Membership | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Reducing Condensation | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Improved Comfort | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Financing & Incentives | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Tools & Resources | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Books & Publications | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Design Considerations | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age.

Science.gov (United States)

Frankenstein, L; Clark, A L; Goode, K; Ingle, L; Remppis, A; Schellberg, D; Grabs, F; Nelles, M; Cleland, J G F; Katus, H A; Zugck, C

2009-05-01

It is unclear whether age-related increases in N-terminal pro-brain natriuretic peptide (NT-proBNP) represent a normal physiological process-possibly affecting the prognostic power-of NT-proBNP-or reflect age-related subclinical pathological changes. To determine the effect of age on the short-term prognostic value of NT-proBNP in patients with chronic heart failure (CHF). Prospective observational study with inclusion and matching of consecutive patients aged >65 years (mean (SD) 73.1 (6.0) years) to patients <65 years (53.7 (8.6) years) with respect to NT-proBNP, New York Heart Association stage, sex and aetiology of CHF (final n = 443). University hospital outpatient departments in the UK and Germany. Chronic stable heart failure due to systolic left ventricular dysfunction. None. All-cause mortality. In both age groups, NT-proBNP was a significant univariate predictor of mortality, and independent of age, sex and other established risk markers. The prognostic information given by NT-proBNP was comparable between the two groups, as reflected by the 1-year mortality of 9% in both groups. The prognostic accuracy of NT-proBNP as judged by the area under the receiver operating characteristics curve for the prediction of 1-year mortality was comparable for elderly and younger patients (0.67 vs 0.71; p = 0.09). NT-proBNP reflects disease severity in elderly and younger patients alike. In patients with chronic stable heart failure, the NT-proBNP value carries the same 1-year prognostic information regardless of the age of the patient.

Three enzymatically active neurotoxins of Clostridium botulinum strain Af84: BoNT/A2, /F4, and /F5.

Science.gov (United States)

Kalb, Suzanne R; Baudys, Jakub; Smith, Theresa J; Smith, Leonard A; Barr, John R

2014-04-01

Botulinum neurotoxins (BoNTs) are produced by various species of clostridia and are potent neurotoxins which cause the disease botulism, by cleaving proteins needed for successful nerve transmission. There are currently seven confirmed serotypes of BoNTs, labeled A-G, and toxin-producing clostridia typically only produce one serotype of BoNT. There are a few strains (bivalent strains) which are known to produce more than one serotype of BoNT, producing either both BoNT/A and /B, BoNT/A and /F, or BoNT/B and /F, designated as Ab, Ba, Af, or Bf. Recently, it was reported that Clostridium botulinum strain Af84 has three neurotoxin gene clusters: bont/A2, bont/F4, and bont/F5. This was the first report of a clostridial organism containing more than two neurotoxin gene clusters. Using a mass spectrometry based proteomics approach, we report here that all three neurotoxins, BoNT/A2, /F4, and /F5, are produced by C. botulinum Af84. Label free MS(E) quantification of the three toxins indicated that toxin composition is 88% BoNT/A2, 1% BoNT/F4, and 11% BoNT/F5. The enzymatic activity of all three neurotoxins was assessed by examining the enzymatic activity of the neurotoxins upon peptide substrates, which mimic the toxins' natural targets, and monitoring cleavage of the substrates by mass spectrometry. We determined that all three neurotoxins are enzymatically active. This is the first report of three enzymatically active neurotoxins produced in a single strain of Clostridium botulinum.

Windows forensic analysis toolkit advanced analysis techniques for Windows 7

CERN Document Server

Carvey, Harlan

2012-01-01

Now in its third edition, Harlan Carvey has updated "Windows Forensic Analysis Toolkit" to cover Windows 7 systems. The primary focus of this edition is on analyzing Windows 7 systems and on processes using free and open-source tools. The book covers live response, file analysis, malware detection, timeline, and much more. The author presents real-life experiences from the trenches, making the material realistic and showing the why behind the how. New to this edition, the companion and toolkit materials are now hosted online. This material consists of electronic printable checklists, cheat sheets, free custom tools, and walk-through demos. This edition complements "Windows Forensic Analysis Toolkit, 2nd Edition", (ISBN: 9781597494229), which focuses primarily on XP. It includes complete coverage and examples on Windows 7 systems. It contains Lessons from the Field, Case Studies, and War Stories. It features companion online material, including electronic printable checklists, cheat sheets, free custom tools, ...

Server consolidation for heterogeneous computer clusters using Colored Petri Nets and CPN Tools

Directory of Open Access Journals (Sweden)

Issam Al-Azzoni

2015-10-01

Full Text Available In this paper, we present a new approach to server consolidation in heterogeneous computer clusters using Colored Petri Nets (CPNs. Server consolidation aims to reduce energy costs and improve resource utilization by reducing the number of servers necessary to run the existing virtual machines in the cluster. It exploits the emerging technology of live migration which allows migrating virtual machines between servers without stopping their provided services. Server consolidation approaches attempt to find migration plans that aim to minimize the necessary size of the cluster. Our approach finds plans which not only minimize the overall number of used servers, but also minimize the total data migration overhead. The latter objective is not taken into consideration by other approaches and heuristics. We explore the use of CPN Tools in analyzing the state spaces of the CPNs. Since the state space of the CPN model can grow exponentially with the size of the cluster, we examine different techniques to generate and analyze the state space in order to find good plans to server consolidation within acceptable time and computing power.

On the optimal use of a slow server in two-stage queueing systems

Science.gov (United States)

Papachristos, Ioannis; Pandelis, Dimitrios G.

2017-07-01

We consider two-stage tandem queueing systems with a dedicated server in each queue and a slower flexible server that can attend both queues. We assume Poisson arrivals and exponential service times, and linear holding costs for jobs present in the system. We study the optimal dynamic assignment of servers to jobs assuming that two servers cannot collaborate to work on the same job and preemptions are not allowed. We formulate the problem as a Markov decision process and derive properties of the optimal allocation for the dedicated (fast) servers. Specifically, we show that the one downstream should not idle, and the same is true for the one upstream when holding costs are larger there. The optimal allocation of the slow server is investigated through extensive numerical experiments that lead to conjectures on the structure of the optimal policy.

Using Web Server Logs in Evaluating Instructional Web Sites.

Science.gov (United States)

Ingram, Albert L.

2000-01-01

Web server logs contain a great deal of information about who uses a Web site and how they use it. This article discusses the analysis of Web logs for instructional Web sites; reviews the data stored in most Web server logs; demonstrates what further information can be gleaned from the logs; and discusses analyzing that information for the…

Advanced energy efficient windows

DEFF Research Database (Denmark)

Thomsen, Kirsten Engelund

2007-01-01

Windows should be paid special attention as they contribute a significant part of the total heat-loss coefficient of the building. Contrary to other parts of the thermal envelope the windows are not only heat loosers, but may gain heat in the day-time. Therefore there are possibilities for large...... energy savings. In terms of energy, windows occupy a special position compared with other thermal envelope structures due to their many functions: 1) windows let daylight into the building and provide occupants with visual contact with their surroundings 2) windows protect against the outdoor climate 3......) windows transmit solar energy that may contribute to a reduction of energy consumption, but which may also lead to unpleasant overheating. In the following paragraphs the current use of windows is reviewed with an emphasis on energy, while special products like solar protection glazing and security...

HPC in a HEP lab: lessons learned from setting up cost-effective HPC clusters

OpenAIRE

Husejko, Michal; Agtzidis, Ioannis; Baehler, Pierre; Dul, Tadeusz; Evans, John; Himyr, Nils; Meinhard, Helge

2015-01-01

In this paper we present our findings gathered during the evaluation and testing of Windows Server High-Performance Computing (Windows HPC) in view of potentially using it as a production HPC system for engineering applications. The Windows HPC package, an extension of Microsofts Windows Server product, provides all essential interfaces, utilities and management functionality for creating, operating and monitoring a Windows-based HPC cluster infrastructure. The evaluation and test phase was f...

Genome sequence of a microbial lipid producing fungus Cryptococcus albidus NT2002.

Science.gov (United States)

Yong, Xiaoyu; Yan, Zhiying; Xu, Lin; Zhou, Jun; Wu, Xiayuan; Wu, Yuandong; Li, Yang; Chen, Zugeng; Zhou, Hua; Wei, Ping; Jia, Honghua

2016-04-10

Cryptococcus albidus NT2002, isolated from the soil in Xinjiang, China, appeared to have the ability to accumulate microbial lipid by utilizing various carbon sources. The predominant properties make it as a potential bio-platform for biodiesel production. Here, we report the complete genome sequence of C. albidus NT2002, which might provide a basis for further elucidation of the genetic background of this promising strain for developing metabolic engineering strategies to produce biodiesel in a green and sustainable manner. Copyright © 2016 Elsevier B.V. All rights reserved.

Web application for monitoring mainframe computer, Linux operating systems and application servers

OpenAIRE

Dimnik, Tomaž

2016-01-01

This work presents the idea and the realization of web application for monitoring the operation of the mainframe computer, servers with Linux operating system and application servers. Web application is intended for administrators of these systems, as an aid to better understand the current state, load and operation of the individual components of the server systems.

Comparison of approaches for mobile document image analysis using server supported smartphones

Science.gov (United States)

Ozarslan, Suleyman; Eren, P. Erhan

2014-03-01

With the recent advances in mobile technologies, new capabilities are emerging, such as mobile document image analysis. However, mobile phones are still less powerful than servers, and they have some resource limitations. One approach to overcome these limitations is performing resource-intensive processes of the application on remote servers. In mobile document image analysis, the most resource consuming process is the Optical Character Recognition (OCR) process, which is used to extract text in mobile phone captured images. In this study, our goal is to compare the in-phone and the remote server processing approaches for mobile document image analysis in order to explore their trade-offs. For the inphone approach, all processes required for mobile document image analysis run on the mobile phone. On the other hand, in the remote-server approach, core OCR process runs on the remote server and other processes run on the mobile phone. Results of the experiments show that the remote server approach is considerably faster than the in-phone approach in terms of OCR time, but adds extra delays such as network delay. Since compression and downscaling of images significantly reduce file sizes and extra delays, the remote server approach overall outperforms the in-phone approach in terms of selected speed and correct recognition metrics, if the gain in OCR time compensates for the extra delays. According to the results of the experiments, using the most preferable settings, the remote server approach performs better than the in-phone approach in terms of speed and acceptable correct recognition metrics.

Windows 8 secrets

CERN Document Server

Thurrott, Paul

2012-01-01

Tips, tricks, treats, and secrets revealed on Windows 8 Microsoft is introducing a major new release of its Windows operating system, Windows 8, and what better way to learn all its ins and outs than from two internationally recognized Windows experts and Microsoft insiders, authors Paul Thurrott and Rafael Rivera? They cut through the hype to get at useful information you'll not find anywhere else, including what role this new OS plays in a mobile and tablet world. Regardless of your level of knowledge, you'll discover little-known facts about how things work, what's new and different, and h

Programming Windows Azure

CERN Document Server

Krishnan, Sriram

2010-01-01

Learn the nuts and bolts of cloud computing with Windows Azure, Microsoft's new Internet services platform. Written by a key member of the product development team, this book shows you how to build, deploy, host, and manage applications using Windows Azure's programming model and essential storage services. Chapters in Programming Windows Azure are organized to reflect the platform's buffet of services. The book's first half focuses on how to write and host application code on Windows Azure, while the second half explains all of the options you have for storing and accessing data on the plat

Beginning Windows 8

CERN Document Server

Halsey, Mike

2012-01-01

Windows 8 has been described by Microsoft as its 'boldest' Windows release ever. Beginning Windows 8 takes you through the new features and helps you get more out of the familiar to reveal the possibilities for this amazing new operating system. You will learn, with non-technical language used throughout, how to get up and running in the new Windows interface, minimize downtime, maximize productivity, and harness the features you never knew existed to take control of your computer and enjoy the peace of mind and excitement that comes with it. From tips and tweaks to easy-to-follow guides and d

Windows 8 tweaks

CERN Document Server

Sinchak, Steve

2013-01-01

Acres of Windows 8 tweaks from a Microsoft MVP and creator of Tweaks.com! From a Microsoft MVP, who is also the savvy creator of Tweaks.com, comes this ultimate collection of Windows 8 workarounds. Steve Sinchak takes you way beyond default system settings, deep under the hood of Windows 8, down to the hidden gems that let you customize your Windows 8 system like you wouldn't believe. From helping you customize the appearance to setting up home networking, sharing media, and squeezing every ounce of performance out of the OS, this book delivers. Get ready to rock and roll with Wind

CERN servers go to Mexico

CERN Multimedia

Stefania Pandolfi

2015-01-01

On Wednesday, 26 August, 384 servers from the CERN Computing Centre were donated to the Faculty of Science in Physics and Mathematics (FCFM) and the Mesoamerican Centre for Theoretical Physics (MCTP) at the University of Chiapas, Mexico.   CERN’s Director-General, Rolf Heuer, met the Mexican representatives in an official ceremony in Building 133, where the servers were prepared for shipment. From left to right: Frédéric Hemmer, CERN IT Department Head; Raúl Heredia Acosta, Deputy Permanent Representative of Mexico to the United Nations and International Organizations in Geneva; Jorge Castro-Valle Kuehne, Ambassador of Mexico to the Swiss Confederation and the Principality of Liechtenstein; Rolf Heuer, CERN Director-General; Luis Roberto Flores Castillo, President of the Swiss Chapter of the Global Network of Qualified Mexicans Abroad; Virginia Romero Tellez, Coordinator of Institutional Relations of the Swiss Chapter of the Global Network of Qualified Me...

The Medicago truncatula gene expression atlas web server

Directory of Open Access Journals (Sweden)

Tang Yuhong

2009-12-01

Full Text Available Abstract Background Legumes (Leguminosae or Fabaceae play a major role in agriculture. Transcriptomics studies in the model legume species, Medicago truncatula, are instrumental in helping to formulate hypotheses about the role of legume genes. With the rapid growth of publically available Affymetrix GeneChip Medicago Genome Array GeneChip data from a great range of tissues, cell types, growth conditions, and stress treatments, the legume research community desires an effective bioinformatics system to aid efforts to interpret the Medicago genome through functional genomics. We developed the Medicago truncatula Gene Expression Atlas (MtGEA web server for this purpose. Description The Medicago truncatula Gene Expression Atlas (MtGEA web server is a centralized platform for analyzing the Medicago transcriptome. Currently, the web server hosts gene expression data from 156 Affymetrix GeneChip® Medicago genome arrays in 64 different experiments, covering a broad range of developmental and environmental conditions. The server enables flexible, multifaceted analyses of transcript data and provides a range of additional information about genes, including different types of annotation and links to the genome sequence, which help users formulate hypotheses about gene function. Transcript data can be accessed using Affymetrix probe identification number, DNA sequence, gene name, functional description in natural language, GO and KEGG annotation terms, and InterPro domain number. Transcripts can also be discovered through co-expression or differential expression analysis. Flexible tools to select a subset of experiments and to visualize and compare expression profiles of multiple genes have been implemented. Data can be downloaded, in part or full, in a tabular form compatible with common analytical and visualization software. The web server will be updated on a regular basis to incorporate new gene expression data and genome annotation, and is accessible

Relationship between CCR and NT-proBNP in Chinese HF patients, and their correlations with severity of HF.

Science.gov (United States)

Lu, Zhigang; Wang, Bo; Wang, Yunliang; Qian, Xueqing; Zheng, Wei; Wei, Meng

2014-01-01

To evaluate the relationship between creatinine clearance rate (CCR) and the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure (HF) patients and their correlations with HF severity. Two hundred and one Chinese patients were grouped according to the New York Heart Association (NYHA) classification as NYHA 1-2 and 3-4 groups and 135 cases out of heart failure patients as control group. The following variables were compared among these three groups: age, sex, body mass index (BMI), smoking status, hypertension, diabetes, NT-proBNP, creatinine (Cr), uric acid (UA), left ventricular end-diastolic diameter (LVEDD), and CCR. The biomarkers of NT-proBNP, Cr, UA, LVEDD, and CCR varied significantly in the three groups, and these variables were positively correlated with the NHYA classification. The levels of NT-proBNP and CCR were closely related to the occurrence of HF and were independent risk factors for HF. At the same time, there was a significant negative correlation between the levels of NT-proBNP and CCR. The area under the receiver operating characteristic curve suggested that the NT-proBNP and CCR have high accuracy for diagnosis of HF and have clinical diagnostic value. NT-proBNP and CCR may be important biomarkers in evaluating the severity of HF.

Involvement of neurotrophin-3 (NT-3) in the functional elimination of synaptic contacts during neuromuscular development.

Science.gov (United States)

Garcia, Neus; Santafé, Manel M; Tomàs, Marta; Lanuza, Maria A; Besalduch, Nuria; Tomàs, Josep

2010-04-05

Confocal immunohistochemistry shows that neurotrophin-3 (NT-3) and its receptor tropomyosin-related tyrosin kinase C (trkC) are present in both neonatal (P6) and adult (P45) mouse motor nerve terminals in neuromuscular junctions (NMJ) colocalized with several synaptic proteins. NT-3 incubation (1-3h, in the range 10-200ng/ml) does not change the size of the evoked and spontaneous endplate potentials at P45. However, NT-3 (1h, 100ng/ml) strongly potentiates evoked ACh release from the weak (70%) and the strong (50%) axonal inputs on dually innervated postnatal endplates (P6) but not in the most developed postnatal singly innervated synapses at P6. The present results indicate that NT-3 has a role in the developmental mechanism that eliminates redundant synapses though it cannot modulate synaptic transmission locally as the NMJ matures.

Professional Microsoft SQL Server 2012 Integration Services

CERN Document Server

Knight, Brian; Moss, Jessica M; Davis, Mike; Rock, Chris

2012-01-01

An in-depth look at the radical changes to the newest release of SISS Microsoft SQL Server 2012 Integration Services (SISS) builds on the revolutionary database product suite first introduced in 2005. With this crucial resource, you will explore how this newest release serves as a powerful tool for performing extraction, transformation, and load operations (ETL). A team of SQL Server experts deciphers this complex topic and provides detailed coverage of the new features of the 2012 product release. In addition to technical updates and additions, the authors present you with a new set of SISS b

Improving consensus contact prediction via server correlation reduction.

Science.gov (United States)

Gao, Xin; Bu, Dongbo; Xu, Jinbo; Li, Ming

2009-05-06

Protein inter-residue contacts play a crucial role in the determination and prediction of protein structures. Previous studies on contact prediction indicate that although template-based consensus methods outperform sequence-based methods on targets with typical templates, such consensus methods perform poorly on new fold targets. However, we find out that even for new fold targets, the models generated by threading programs can contain many true contacts. The challenge is how to identify them. In this paper, we develop an integer linear programming model for consensus contact prediction. In contrast to the simple majority voting method assuming that all the individual servers are equally important and independent, the newly developed method evaluates their correlation by using maximum likelihood estimation and extracts independent latent servers from them by using principal component analysis. An integer linear programming method is then applied to assign a weight to each latent server to maximize the difference between true contacts and false ones. The proposed method is tested on the CASP7 data set. If the top L/5 predicted contacts are evaluated where L is the protein size, the average accuracy is 73%, which is much higher than that of any previously reported study. Moreover, if only the 15 new fold CASP7 targets are considered, our method achieves an average accuracy of 37%, which is much better than that of the majority voting method, SVM-LOMETS, SVM-SEQ, and SAM-T06. These methods demonstrate an average accuracy of 13.0%, 10.8%, 25.8% and 21.2%, respectively. Reducing server correlation and optimally combining independent latent servers show a significant improvement over the traditional consensus methods. This approach can hopefully provide a powerful tool for protein structure refinement and prediction use.

Improving consensus contact prediction via server correlation reduction

Directory of Open Access Journals (Sweden)

Xu Jinbo

2009-05-01

Full Text Available Abstract Background Protein inter-residue contacts play a crucial role in the determination and prediction of protein structures. Previous studies on contact prediction indicate that although template-based consensus methods outperform sequence-based methods on targets with typical templates, such consensus methods perform poorly on new fold targets. However, we find out that even for new fold targets, the models generated by threading programs can contain many true contacts. The challenge is how to identify them. Results In this paper, we develop an integer linear programming model for consensus contact prediction. In contrast to the simple majority voting method assuming that all the individual servers are equally important and independent, the newly developed method evaluates their correlation by using maximum likelihood estimation and extracts independent latent servers from them by using principal component analysis. An integer linear programming method is then applied to assign a weight to each latent server to maximize the difference between true contacts and false ones. The proposed method is tested on the CASP7 data set. If the top L/5 predicted contacts are evaluated where L is the protein size, the average accuracy is 73%, which is much higher than that of any previously reported study. Moreover, if only the 15 new fold CASP7 targets are considered, our method achieves an average accuracy of 37%, which is much better than that of the majority voting method, SVM-LOMETS, SVM-SEQ, and SAM-T06. These methods demonstrate an average accuracy of 13.0%, 10.8%, 25.8% and 21.2%, respectively. Conclusion Reducing server correlation and optimally combining independent latent servers show a significant improvement over the traditional consensus methods. This approach can hopefully provide a powerful tool for protein structure refinement and prediction use.

3Drefine: an interactive web server for efficient protein structure refinement.

Science.gov (United States)

Bhattacharya, Debswapna; Nowotny, Jackson; Cao, Renzhi; Cheng, Jianlin

2016-07-08

3Drefine is an interactive web server for consistent and computationally efficient protein structure refinement with the capability to perform web-based statistical and visual analysis. The 3Drefine refinement protocol utilizes iterative optimization of hydrogen bonding network combined with atomic-level energy minimization on the optimized model using a composite physics and knowledge-based force fields for efficient protein structure refinement. The method has been extensively evaluated on blind CASP experiments as well as on large-scale and diverse benchmark datasets and exhibits consistent improvement over the initial structure in both global and local structural quality measures. The 3Drefine web server allows for convenient protein structure refinement through a text or file input submission, email notification, provided example submission and is freely available without any registration requirement. The server also provides comprehensive analysis of submissions through various energy and statistical feedback and interactive visualization of multiple refined models through the JSmol applet that is equipped with numerous protein model analysis tools. The web server has been extensively tested and used by many users. As a result, the 3Drefine web server conveniently provides a useful tool easily accessible to the community. The 3Drefine web server has been made publicly available at the URL: http://sysbio.rnet.missouri.edu/3Drefine/. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Window selection for dual photopeak window scatter correction in Tc-99m imaging

International Nuclear Information System (INIS)

Vries, D.J. de; King, M.A.

1994-01-01

The width and placement of the windows for the dual photopeak window (DPW) scatter subtraction method for Tc-99m imaging is investigated in order to obtain a method that is stable on a multihead detector system for single photon emission computed tomography (SPECT) and is capable of providing a good scatter estimate for extended objects. For various window pairs, stability and noise were examined with experiments using a SPECT system, while Monte Carlo simulations were used to predict the accuracy of scatter estimates for a variety of objects and to guide the development of regression relations for various window pairs. The DPW method that resulted from this study was implemented with a symmetric 20% photopeak window composed of a 15% asymmetric photopeak window and a 5% lower window abutted at 7 keV below the peak. A power function regression was used to relate the scatter-to-total ratio to the lower window-to-total ratio at each pixel, from which an estimated scatter image was calculated. DPW demonstrated good stability, achieved by abutting the two windows away from the peak. Performance was assessed and compared with Compton window subtraction (CWS). For simulated extended objects, DPW generally produced a less biased scatter estimate than the commonly used CWS method with k = 0.5. In acquisitions of a clinical SPECT phantom, contrast recovery was comparable for both DPW and CWS; however, DPW showed greater visual contrast in clinical SPECT bone studies

EarthServer: Cross-Disciplinary Earth Science Through Data Cube Analytics

Science.gov (United States)

Baumann, P.; Rossi, A. P.

2016-12-01

The unprecedented increase of imagery, in-situ measurements, and simulation data produced by Earth (and Planetary) Science observations missions bears a rich, yet not leveraged potential for getting insights from integrating such diverse datasets and transform scientific questions into actual queries to data, formulated in a standardized way.The intercontinental EarthServer [1] initiative is demonstrating new directions for flexible, scalable Earth Science services based on innovative NoSQL technology. Researchers from Europe, the US and Australia have teamed up to rigorously implement the concept of the datacube. Such a datacube may have spatial and temporal dimensions (such as a satellite image time series) and may unite an unlimited number of scenes. Independently from whatever efficient data structuring a server network may perform internally, users (scientist, planners, decision makers) will always see just a few datacubes they can slice and dice.EarthServer has established client [2] and server technology for such spatio-temporal datacubes. The underlying scalable array engine, rasdaman [3,4], enables direct interaction, including 3-D visualization, common EO data processing, and general analytics. Services exclusively rely on the open OGC "Big Geo Data" standards suite, the Web Coverage Service (WCS). Conversely, EarthServer has shaped and advanced WCS based on the experience gained. The first phase of EarthServer has advanced scalable array database technology into 150+ TB services. Currently, Petabyte datacubes are being built for ad-hoc and cross-disciplinary querying, e.g. using climate, Earth observation and ocean data.We will present the EarthServer approach, its impact on OGC / ISO / INSPIRE standardization, and its platform technology, rasdaman.References: [1] Baumann, et al. (2015) DOI: 10.1080/17538947.2014.1003106 [2] Hogan, P., (2011) NASA World Wind, Proceedings of the 2nd International Conference on Computing for Geospatial Research

Multimedia medical data archive and retrieval server on the Internet

Science.gov (United States)

Komo, Darmadi; Levine, Betty A.; Freedman, Matthew T.; Mun, Seong K.; Tang, Y. K.; Chiang, Ted T.

1997-05-01

The Multimedia Medical Data Archive and Retrieval Server has been installed at the imaging science and information systems (ISIS) center in Georgetown University Medical Center to provide medical data archive and retrieval support for medical researchers. The medical data includes text, images, sound, and video. All medical data is keyword indexed using a database management system and placed temporarily in a staging area and then transferred to a StorageTek one terabyte tape library system with a robotic arm for permanent archive. There are two methods of interaction with the system. The first method is to use a web browser with HTML functions to perform insert, query, update, and retrieve operations. These generate dynamic SQL calls to the database and produce StorageTek API calls to the tape library. The HTML functions consist of a database, StorageTek interface, HTTP server, common gateway interface, and Java programs. The second method is to issue a DICOM store command, which is translated by the system's DICOM server to SQL calls and then produce StorageTek API calls to the tape library. The system performs as both an Internet and a DICOM server using standard protocols such as HTTP, HTML, Java, and DICOM. Users with proper authentication can log on to the server from anywhere on the Internet using a standard web browser resulting in a user-friendly, open environment, and platform independent solution for archiving multimedia medical data. It represents a complex integration of different components including a robotic tape storage system, database, user-interface, WWW protocols, and TCP/IP networking. The user will only deal with the WWW and DICOM server components of the system, the database and robotic tape library system are transparent and the user will not know that the medical data is stored on magnetic tapes. The server provides the researchers a cost-effective tool for archiving and retrieving medical data across a TCP/IP network environment. It will

Round-Trip Delay Estimation in OPC UA Server-Client Communication Channel

OpenAIRE

Nakutis, Zilvinas; Deksnys, Vytautas; Jarusevicius, Ignas; Dambrauskas, Vilius; Cincikas, Gediminas; Kriauceliunas, Alenas

2017-01-01

In this paper an estimation of round-trip delay (RTD) in OPC UA server-client channel was investigated in various data communication networks including Ethernet, WiFi, and 3G. Testing was carried out using the developed IoT gateway device running OPC UA server and remote computer running OPC UA client. The server and the client machines were configured to operate in Virtual Private Network powered by OpenVPN. Experimental analysis revealed that RTD values are distributed in the wide range exh...

MCTBI: a web server for predicting metal ion effects in RNA structures.

Science.gov (United States)

Sun, Li-Zhen; Zhang, Jing-Xiang; Chen, Shi-Jie

2017-08-01

Metal ions play critical roles in RNA structure and function. However, web servers and software packages for predicting ion effects in RNA structures are notably scarce. Furthermore, the existing web servers and software packages mainly neglect ion correlation and fluctuation effects, which are potentially important for RNAs. We here report a new web server, the MCTBI server (http://rna.physics.missouri.edu/MCTBI), for the prediction of ion effects for RNA structures. This server is based on the recently developed MCTBI, a model that can account for ion correlation and fluctuation effects for nucleic acid structures and can provide improved predictions for the effects of metal ions, especially for multivalent ions such as Mg 2+ effects, as shown by extensive theory-experiment test results. The MCTBI web server predicts metal ion binding fractions, the most probable bound ion distribution, the electrostatic free energy of the system, and the free energy components. The results provide mechanistic insights into the role of metal ions in RNA structure formation and folding stability, which is important for understanding RNA functions and the rational design of RNA structures. © 2017 Sun et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

From honeybees to Internet servers: biomimicry for distributed management of Internet hosting centers.

Science.gov (United States)

Nakrani, Sunil; Tovey, Craig

2007-12-01

An Internet hosting center hosts services on its server ensemble. The center must allocate servers dynamically amongst services to maximize revenue earned from hosting fees. The finite server ensemble, unpredictable request arrival behavior and server reallocation cost make server allocation optimization difficult. Server allocation closely resembles honeybee forager allocation amongst flower patches to optimize nectar influx. The resemblance inspires a honeybee biomimetic algorithm. This paper describes details of the honeybee self-organizing model in terms of information flow and feedback, analyzes the homology between the two problems and derives the resulting biomimetic algorithm for hosting centers. The algorithm is assessed for effectiveness and adaptiveness by comparative testing against benchmark and conventional algorithms. Computational results indicate that the new algorithm is highly adaptive to widely varying external environments and quite competitive against benchmark assessment algorithms. Other swarm intelligence applications are briefly surveyed, and some general speculations are offered regarding their various degrees of success.

Increased NT-pro-B-type natriuretic peptide independently predicts outcome following catheter ablation of atrial fibrillation

DEFF Research Database (Denmark)

Nilsson, Brian; Goetze, Jens Peter; Chen, Xu

2009-01-01

AIMS: To investigate whether NT-proBNP before ablation treatment and after exercise testing has predictive information regarding the clinical outcome following pulmonary vein isolation in patients with atrial fibrillation (AF). METHODS: NT-proBNP analysis were obtained before the ablation (before...

Prenatal Clinical Assessment of NT-proBNP as a Diagnostic Tool for Preeclampsia, Gestational Hypertension and Gestational Diabetes Mellitus.

Directory of Open Access Journals (Sweden)

Pawel Sadlecki

Full Text Available Common complications of pregnancy include preeclampsia (PE, gestational hypertension (GH and gestational diabetes mellitus (GDM. Hypertensive disorders (PE/GH and GDM may result in greater maternal, fetal and neonatal morbidity and mortality. Women with PE/GH, one of the most common causes of heart burden in an obstetrical setting, present with elevated serum levels of BNP and NT-proBNP. The aim of this study was to shed more light on the role of NT-proBNP in pathophysiology of PE, GH and GDM. The study included 156 pregnant women with singleton pregnancies. A total of 26 women developed arterial hypertension during pregnancy, 14 were diagnosed with PE, and GDM was detected in 81 patients. The control group included 35 women with uncomplicated pregnancies, normal arterial blood pressure and normal glucose concentrations. Patients with GH presented with significantly higher serum concentrations of NT-proBNPthan normotensive women (65.5 vs. 37.4 pg/ml; p = 0.0136. Serum levels of NT-proBNP in patients with PE were the highest of all the analyzed subsets, being significantly higher than in women without this condition (89.00 vs. 37.4pg/ml,p = 0,0136. However, women with and without GDM did not differ significantly in terms of their serum NT-proBNPconcentrations. Serum NT-proBNP (pg/ml (p = 0.0001 and BMI (p<0.0001 turned out to be independent predictors of GH on multivariate logistic regression analysis.Moreover, serum NT-proBNP (pg/ml was identified as an independent indicator of PE (p = 0.0016. A significant inverse correlation was found between birth weight and maternal serum NT-proBNP concentrations. In our opinion, NT-proBNP can be a useful clinical marker of GH and PE. Determination of NT-proBNP levels may be helpful in identification of patients with PE and GH and in their qualification for intensive treatment; this in turn, may be reflected by better neonatal outcomes.

Building server capabilities in China

DEFF Research Database (Denmark)

Adeyemi, Oluseyi; Slepniov, Dmitrij; Wæhrens, Brian Vejrum

2012-01-01

The purpose of this paper is to further our understanding of multinational companies building server capabilities in China. The paper is based on the cases of two western companies with operations in China. The findings highlight a number of common patterns in the 1) managerial challenges related...

PENGEMBANGAN ANTIVIRUS BERBASIS CLIENT SERVER

Directory of Open Access Journals (Sweden)

Richki Hardi

2015-07-01

Full Text Available The era of globalization is included era where the komputer virus has been growing rapidly, not only of mere academic research but has become a common problem for komputer users in the world. The effect of this loss is increasingly becoming the widespread use of the Internet as a global communication line between komputer users around the world, based on the results of the survey CSI / FB. Along with the progress, komputer viruses undergo some evolution in shape, characteristics and distribution medium such as Worms, Spyware Trojan horse and program Malcodelain. Through the development of server-based antivirus clien then the user can easily determine the behavior of viruses and worms, knowing what part of an operating system that is being attacked by viruses and worms, making itself a development of network-based antivirus client server and can also be relied upon as an engine fast and reliable scanner to recognize the virus and saving in memory management.

CERN servers donated to Ghana

CERN Multimedia

CERN Bulletin

2012-01-01

Cutting-edge research requires a constantly high performance of the computing equipment. At the CERN Computing Centre, computers typically need to be replaced after about four years of use. However, while servers may be withdrawn from cutting-edge use, they are still good for other uses elsewhere. This week, 220 servers and 30 routers were donated to the Kwame Nkrumah University of Science and Technology (KNUST) in Ghana.   “KNUST will provide a good home for these computers. The university has also developed a plan for using them to develop scientific collaboration with CERN,” said John Ellis, a professor at King’s College London and a visiting professor in CERN’s Theory Group.  John Ellis was heavily involved in building the relationship with Ghana, which started in 2006 when a Ghanaian participated in the CERN openlab student programme. Since 2007 CERN has hosted Ghanaians especially from KNUST in the framework of the CERN Summer Student Progr...

The predictive value of plasma biomarkers in discharged heart failure patients: role of plasma NT-proBNP.

Science.gov (United States)

Leto, Laura; Testa, Marzia; Feola, Mauro

2016-04-01

Natriuretic peptides (NPs) have demonstrated their value to support clinical diagnosis of heart failure (HF); furthermore they are also studied for their prognostic role using them to guide appropriate management strategies. The present review gathers available evidence on prognostic role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients hospitalized for acute decompensated heart failure (ADHF). We searched Medline for English-language studies with the sequent key-words: "acute heart failure/acute decompensated heart failure", "NT-proBNP/N-terminal pro-B type natriuretic peptide" and "prognosis/mortality/readmission". Almost 30 studies were included. NT-proBNP plasma levels at admission are strongly associated with all-cause short-term mortality (2-3 months), mid-term (6-11 months) or long- term mortality (more than one year) of follow-up. Regarding the prognostic power on cardiac death fewer data are available with uncertain results. NT-proBNP at discharge demonstrated its prognostic role for all-cause mortality at mid and long-term follow-up. The relation between NT-proBNP at discharge and cardiovascular mortality or composite end-point is under investigation. A decrease in NT-proBNP values during hospitalization provided prognostic prospects mainly for cardiovascular mortality and HF readmission. A 30% variation in NT-proBNP levels during in-hospital stay seemed to be an optimal cut-off for prognostic role. SNT-proBNP plasma levels proved to have a strong correlation with all-cause mortality, cardiovascular mortality, morbidity and composite outcomes in patients discharged after an ADHF. A better definition of the correct time of serial measurements and the cut-off values might be the challenge for the future investigations.

Extremely intense (SML ≤–2500 nT substorms: isolated events that are externally triggered?

Directory of Open Access Journals (Sweden)

B. T. Tsurutani

2015-05-01

Full Text Available We examine particularly intense substorms (SML ≤–2500 nT, hereafter called "supersubstorms" or SSS events, to identify their nature and their magnetic storm dependences. It is found that these intense substorms are typically isolated events and are only loosely related to magnetic storms. SSS events can occur during super (Dst ≤–250 nT and intense (−100 nT ≥ Dst >–250 magnetic storms. SSS events can also occur during nonstorm (Dst ≥–50 nT intervals. SSSs are important because the strongest ionospheric currents will flow during these events, potentially causing power outages on Earth. Several SSS examples are shown. SSS events appear to be externally triggered by small regions of very high density (~30 to 50 cm−3 solar wind plasma parcels (PPs impinging upon the magnetosphere. Precursor southward interplanetary magnetic fields are detected prior to the PPs hitting the magnetosphere. Our hypothesis is that these southward fields input energy into the magnetosphere/magnetotail and the PPs trigger the release of the stored energy.

PANNZER2: a rapid functional annotation web server.

Science.gov (United States)

Törönen, Petri; Medlar, Alan; Holm, Liisa

2018-05-08

The unprecedented growth of high-throughput sequencing has led to an ever-widening annotation gap in protein databases. While computational prediction methods are available to make up the shortfall, a majority of public web servers are hindered by practical limitations and poor performance. Here, we introduce PANNZER2 (Protein ANNotation with Z-scoRE), a fast functional annotation web server that provides both Gene Ontology (GO) annotations and free text description predictions. PANNZER2 uses SANSparallel to perform high-performance homology searches, making bulk annotation based on sequence similarity practical. PANNZER2 can output GO annotations from multiple scoring functions, enabling users to see which predictions are robust across predictors. Finally, PANNZER2 predictions scored within the top 10 methods for molecular function and biological process in the CAFA2 NK-full benchmark. The PANNZER2 web server is updated on a monthly schedule and is accessible at http://ekhidna2.biocenter.helsinki.fi/sanspanz/. The source code is available under the GNU Public Licence v3.

Minimizing cache misses in an event-driven network server: A case study of TUX

DEFF Research Database (Denmark)

Bhatia, Sapan; Consel, Charles; Lawall, Julia Laetitia

2006-01-01

We analyze the performance of CPU-bound network servers and demonstrate experimentally that the degradation in the performance of these servers under high-concurrency workloads is largely due to inefficient use of the hardware caches. We then describe an approach to speeding up event-driven network...... servers by optimizing their use of the L2 CPU cache in the context of the TUX Web server, known for its robustness to heavy load. Our approach is based on a novel cache-aware memory allocator and a specific scheduling strategy that together ensure that the total working data set of the server stays...

Clustering results - Gclust Server | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us Gclust Server Clustering results Data detail Data name Clustering results DOI 10.18908/lsdba...se Update History of This Database Site Policy | Contact Us Clustering results - Gclust Server | LSDB Archive ...

Biological profile of {sup 99m}Tc-HYNIC-betaAla-NT(8-13) in MDAMB-231 breast cancer cell line

Energy Technology Data Exchange (ETDEWEB)

Teodoro, Rodrigo; Faintuch, Bluma L.; Wiecek, Danielle P.; Silva, Natanael G.; Vallejo, Natalia M., E-mail: teodoro_rodrigo@yahoo.com.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Diretoria de Radiofarmacia

2009-07-01

Introduction: Neurotensin (NT) is a tridecapeptide involved in several growth-steps of human cancers. Recent studies postulated the role of NT and NT-receptor subtype 1 in breast cancer progression. However, the main drawback of natural NT is its rapid degradation in plasma. In an effort to develop a NT peptide-based radiopharmaceutical for the detection of breast cancer, the aim of this study was the radiolabeling of the double stabilized NT(8-13) peptide using HYNIC as chelating agent. Methods: Conjugated HYNIC-betaAla-NT(8-13) was labeled with {sup 99m}Tc using tricine and EDDA as coligands. Radiochemical purity was checked by TLC and confirmed by RP-HPLC. {sup 99m}Tc-HYNIC-betaAla-NT(8-13) (0.1 mL/74 MBq) was administered in Nude mice bearing MDA-MB-231 breast cancer cells and biodistribution studies were carried out at 30 and 90 min postinjection (pi). Blocking evaluation was also conducted by co-injection of 115 nmol of cold NT (8-13) analog. Planar gamma-camera imaging was acquired at the earlier time point studied. Results: Radiochemical purity of the radioconjugate was higher than 99%. Biodistribution studies revealed a very fast accumulation in tumor (1.97+-0.18% ID/g, 30 min pi) with a sharply decrease at the later time point studied (0.44+-0.02% ID/g). The specificity of the radioconjugate was evaluated with blockade studies. A reduction of 45.94%, 27.73% and 36.39% was found for tumor, large and small intestines, respectively, at 30 min pi. Otherwise, a less impressive blockade was observed for tumor and small intestine (28.68% and 24.90%, respectively) at the later time point studied. Conclusion: The results provide encouraging evidence in the development of radiolabeled NT(8-13) analogues for breast cancer diagnosis. (author)

Assessment of physical server reliability in multi cloud computing system

Science.gov (United States)

Kalyani, B. J. D.; Rao, Kolasani Ramchand H.

2018-04-01

Business organizations nowadays functioning with more than one cloud provider. By spreading cloud deployment across multiple service providers, it creates space for competitive prices that minimize the burden on enterprises spending budget. To assess the software reliability of multi cloud application layered software reliability assessment paradigm is considered with three levels of abstractions application layer, virtualization layer, and server layer. The reliability of each layer is assessed separately and is combined to get the reliability of multi-cloud computing application. In this paper, we focused on how to assess the reliability of server layer with required algorithms and explore the steps in the assessment of server reliability.

Towards Big Earth Data Analytics: The EarthServer Approach

Science.gov (United States)

Baumann, Peter

2013-04-01

Big Data in the Earth sciences, the Tera- to Exabyte archives, mostly are made up from coverage data whereby the term "coverage", according to ISO and OGC, is defined as the digital representation of some space-time varying phenomenon. Common examples include 1-D sensor timeseries, 2-D remote sensing imagery, 3D x/y/t image timeseries and x/y/z geology data, and 4-D x/y/z/t atmosphere and ocean data. Analytics on such data requires on-demand processing of sometimes significant complexity, such as getting the Fourier transform of satellite images. As network bandwidth limits prohibit transfer of such Big Data it is indispensable to devise protocols allowing clients to task flexible and fast processing on the server. The EarthServer initiative, funded by EU FP7 eInfrastructures, unites 11 partners from computer and earth sciences to establish Big Earth Data Analytics. One key ingredient is flexibility for users to ask what they want, not impeded and complicated by system internals. The EarthServer answer to this is to use high-level query languages; these have proven tremendously successful on tabular and XML data, and we extend them with a central geo data structure, multi-dimensional arrays. A second key ingredient is scalability. Without any doubt, scalability ultimately can only be achieved through parallelization. In the past, parallelizing code has been done at compile time and usually with manual intervention. The EarthServer approach is to perform a samentic-based dynamic distribution of queries fragments based on networks optimization and further criteria. The EarthServer platform is comprised by rasdaman, an Array DBMS enabling efficient storage and retrieval of any-size, any-type multi-dimensional raster data. In the project, rasdaman is being extended with several functionality and scalability features, including: support for irregular grids and general meshes; in-situ retrieval (evaluation of database queries on existing archive structures, avoiding data

CLC-Nt1, a putative chloride channel protein of tobacco, co-localizes with mitochondrial membrane markers.

Science.gov (United States)

Lurin, C; Güclü, J; Cheniclet, C; Carde, J P; Barbier-Brygoo, H; Maurel, C

2000-06-01

The voltage-dependent chloride channel (CLC) family of membrane proteins has cognates in animals, yeast, bacteria and plants, and chloride-channel activity has been assigned to most of the animal homologues. Lack of evidence of CLC functions in plants prompted us to characterize the cellular localization of the tobacco CLC-Nt1 protein. Specific polyclonal antibodies were raised against an N-terminal polypeptide of CLC-Nt1. These antibodies were used to probe membrane proteins prepared by various cell-fractionation methods. These included aqueous two-phase partitioning (for plasma membranes), free-flow electrophoresis (for vacuolar and plasma membranes), intact vacuole isolation, Percoll-gradient centrifugation (for plastids and mitochondria) and stepped, linear, sucrose-density-gradient centrifugation (for mitochondria). Each purified membrane fraction was characterized with specific marker enzyme activities or antibodies. Our studies ruled out the possibility that the major cell localization of CLC-Nt1 was the vacuolar or plasma membranes, the endoplasmic reticulum, the Golgi apparatus or the plastids. In contrast, we showed that the tobacco CLC-Nt1 specifically co-localized with the markers of the mitochondrial inner membrane, cytochrome c oxidase and NAD9 protein. CLC-Nt1 may correspond to the inner membrane anion channel ('IMAC') described previously in animal and plant mitochondria.

GLI1 is involved in cell cycle regulation and proliferation of NT2 embryonal carcinoma stem cells

DEFF Research Database (Denmark)

Vestergaard, Janni; Lind-Thomsen, Allan; Pedersen, Mikkel W.

2008-01-01

of altered HH signaling are interpreted by specific cell types. We have investigated the role of the HH transcription factor glioma-associated oncogene homolog 1 (GLI1) in the human Ntera2=D1 (NT2) embryonal carcinoma stem cell line. The study revealed that expression of GLI1 and its direct transcriptional......1 phase cyclins. In conclusion, our results suggest that GLI1 is involved in cell cycle and proliferation control in the embryonal carcinoma stem cell line NT2....... target Patched (PTCH) is downregulated in the early stages of retinoic acid-induced neuronal differentiation of NT2 cells. To identify transcriptional targets of the HH transcription factor GLI1 in NT2 cells, we performed global expression profiling following GLI1 RNA interference (RNAi). Of the similar...

Use of the decision support system RECASS NT (Radio Ecological Analysis Support System) for anti terrorism actions

International Nuclear Information System (INIS)

Bulgakov, V.G.; Gariyants, A.M.; Kosykh, V.S.; Shershakov, V.M.

2006-01-01

Decision support system RECASS NT (Radio Ecological Analysis Support System) was developed and is still enhancing in Federal Service Roshydromet for providing on-line estimates and prognoses of radiation and chemical situation in the event of an emergency, including acts of terrorism, as well as to estimate transboundary pollutants transport. RECASS NT has been installed at all ten NPPs of the Russian Federation, in Crisis Centers of Roshydromet, concern Rosenergoatom and Minatom, at plants for destroying chemical weapons. The paper describes the structure of RECASS NT system and discuss its possible application in case of an emergency on examples of using the system during radiation emergency response exercises at NPPs. RECASS NT can be used for developing recommendations regarding time when anti terrorism operations are better to be started with a view to minimize damage

NT-proBNP in unstable coronary artery disease--experiences from the FAST, GUSTO IV and FRISC II trials.

Science.gov (United States)

Jernberg, Tomas; James, Stefan; Lindahl, Bertil; Stridsberg, Mats; Venge, Per; Wallentin, Lars

2004-03-15

Risk stratification is important in patients with unstable coronary artery disease (CAD), i.e. unstable angina or non-ST-elevation myocardial infarction. This article focuses on the emerging role of N-terminal pro brain natriuretic peptide (NT-proBNP) and the results from the FAST, GUSTO IV and FRISC II trials. In the FAST study, NT-proBNP was measured on admission in 755 patients admitted because of symptoms suggestive of unstable CAD. Follow up was performed after 40 months. The GUSTO IV and the FRISC II-trials included patients with unstable CAD and NT-proBNP was analyzed in 6806 and 2019 patients, with follow up after 1 and 2 years, respectively. In the FAST study, patients in the 2nd, 3rd, and 4th NT-proBNP quartile had a relative risk of subsequent death of 4.2 (1.6-11.1), 10.7 (4.2-26.8) and 26.6 (10.8-65.5), respectively. In the GUSTO IV trial, increasing quartiles of NT-proBNP were related to short and long term mortality which at 1 year was; 1.8%, 3.9%, 7.7% and 19.2% (P<0.001), respectively. In multivariable analyses including well-known predictors of outcome, NT-proBNP level was independently associated to mortality in all three studies. In the FRISC II trial, the NT-proBNP level, especially if combined with a marker of inflammation, identified those with the greatest benefit from an early invasive strategy. NT-proBNP is strongly associated with mortality in patients with suspected or confirmed unstable CAD and, combined with a marker of inflammation, seems helpful in identifying those with greatest benefit from an early invasive strategy.

Analysis of the Macroscopic Behavior of Server Systems in the Internet Environment

Directory of Open Access Journals (Sweden)

Yusuke Tanimura

2017-11-01

Full Text Available Elasticity is one of the key features of cloud-hosted services built on virtualization technology. To utilize the elasticity of cloud environments, administrators should accurately capture the operational status of server systems, which changes constantly according to service requests incoming irregularly. However, it is difficult to detect and avoid in advance that operating services are falling into an undesirable state. In this paper, we focus on the management of server systems that include cloud systems, and propose a new method for detecting the sign of undesirable scenarios before the system becomes overloaded as a result of various causes. In this method, a measure that utilizes the fluctuation of the macroscopic operational state observed in the server system is introduced. The proposed measure has the property of drastically increasing before the server system is in an undesirable state. Using the proposed measure, we realize a function to detect that the server system is falling into an overload scenario, and we demonstrate its effectiveness through experiments.

The FOLDALIGN web server for pairwise structural RNA alignment and mutual motif search

DEFF Research Database (Denmark)

Havgaard, Jakob Hull; Lyngsø, Rune B.; Gorodkin, Jan

2005-01-01

FOLDALIGN is a Sankoff-based algorithm for making structural alignments of RNA sequences. Here, we present a web server for making pairwise alignments between two RNA sequences, using the recently updated version of FOLDALIGN. The server can be used to scan two sequences for a common structural RNA...... motif of limited size, or the entire sequences can be aligned locally or globally. The web server offers a graphical interface, which makes it simple to make alignments and manually browse the results. the web server can be accessed at http://foldalign.kvl.dk...

Windows for Intel Macs

CERN Document Server

Ogasawara, Todd

2008-01-01

Even the most devoted Mac OS X user may need to use Windows XP, or may just be curious about XP and its applications. This Short Cut is a concise guide for OS X users who need to quickly get comfortable and become productive with Windows XP basics on their Macs. It covers: Security Networking ApplicationsMac users can easily install and use Windows thanks to Boot Camp and Parallels Desktop for Mac. Boot Camp lets an Intel-based Mac install and boot Windows XP on its own hard drive partition. Parallels Desktop for Mac uses virtualization technology to run Windows XP (or other operating systems

Selection of Server-Side Technologies for an E-Business Curriculum

Science.gov (United States)

Sandvig, J. Christopher

2007-01-01

The rapid growth of e-business and e-commerce has made server-side programming an increasingly important topic in information systems (IS) and computer science (CS) curricula. This article presents an overview of the major features of several popular server-side programming technologies and discusses the factors that influence the selection of…

NT-proBNP, echocardiographic abnormalities and subclinical coronary artery disease in high risk type 2 diabetic patients

DEFF Research Database (Denmark)

Reinhard, Henrik; Hansen, Peter R; Wiinberg, Niels

2012-01-01

-NT-proBNP and the putative residual abnormalities in such patients are not well described. This study examined echocardiographic measurements of LV hypertrophy, atrial dilatation and LV dysfunction and their relation to P-NT-proBNP levels or subclinical coronary artery disease (CAD) in type 2 diabetic patients......Intensive multifactorial treatment aimed at prevention of cardiovascular (CV) disease may reduce left ventricular (LV) echocardiographic abnormalities in diabetic subjects. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the association between P...

Retrieving high-resolution images over the Internet from an anatomical image database

Science.gov (United States)

Strupp-Adams, Annette; Henderson, Earl

1999-12-01

The Visible Human Data set is an important contribution to the national collection of anatomical images. To enhance the availability of these images, the National Library of Medicine has supported the design and development of a prototype object-oriented image database which imports, stores, and distributes high resolution anatomical images in both pixel and voxel formats. One of the key database modules is its client-server Internet interface. This Web interface provides a query engine with retrieval access to high-resolution anatomical images that range in size from 100KB for browser viewable rendered images, to 1GB for anatomical structures in voxel file formats. The Web query and retrieval client-server system is composed of applet GUIs, servlets, and RMI application modules which communicate with each other to allow users to query for specific anatomical structures, and retrieve image data as well as associated anatomical images from the database. Selected images can be downloaded individually as single files via HTTP or downloaded in batch-mode over the Internet to the user's machine through an applet that uses Netscape's Object Signing mechanism. The image database uses ObjectDesign's object-oriented DBMS, ObjectStore that has a Java interface. The query and retrieval systems has been tested with a Java-CDE window system, and on the x86 architecture using Windows NT 4.0. This paper describes the Java applet client search engine that queries the database; the Java client module that enables users to view anatomical images online; the Java application server interface to the database which organizes data returned to the user, and its distribution engine that allow users to download image files individually and/or in batch-mode.

MCTS (Exams 70-640, 70-642 and 70-643)

CERN Document Server

Panek, William

2011-01-01

The must-have study guide for all three Windows Server 2008 R2 MCTS examsNetwork administrators boost their value to their employers with certification, and Microsoft?s three Windows Server 2008 exams offer certification specialties in configuring Active Directory, Network Infrastructure, and Applications Infrastructure. With complete coverage to prepare you for all three exams, this comprehensive study guide has three times the value. Real-world scenarios and hands-on exercises supplement the information to facilitate learning.The three Windows Server 2008 R2 exams (70-640, 70-642, and 70-643

Distributed control system for demand response by servers

Science.gov (United States)

Hall, Joseph Edward

Within the broad topical designation of smart grid, research in demand response, or demand-side management, focuses on investigating possibilities for electrically powered devices to adapt their power consumption patterns to better match generation and more efficiently integrate intermittent renewable energy sources, especially wind. Devices such as battery chargers, heating and cooling systems, and computers can be controlled to change the time, duration, and magnitude of their power consumption while still meeting workload constraints such as deadlines and rate of throughput. This thesis presents a system by which a computer server, or multiple servers in a data center, can estimate the power imbalance on the electrical grid and use that information to dynamically change the power consumption as a service to the grid. Implementation on a testbed demonstrates the system with a hypothetical but realistic usage case scenario of an online video streaming service in which there are workloads with deadlines (high-priority) and workloads without deadlines (low-priority). The testbed is implemented with real servers, estimates the power imbalance from the grid frequency with real-time measurements of the live outlet, and uses a distributed, real-time algorithm to dynamically adjust the power consumption of the servers based on the frequency estimate and the throughput of video transcoder workloads. Analysis of the system explains and justifies multiple design choices, compares the significance of the system in relation to similar publications in the literature, and explores the potential impact of the system.

Windows XP ends its life at CERN – register for Windows 7 training!

CERN Multimedia

Michał Kwiatek (IT-OIS)

2012-01-01

Windows XP has been around for over 10 years and it is now time to move on. At CERN, general support for Windows XP will end in December 2012, and before this date users are requested to schedule a migration to the next version of Windows – Windows 7.   Windows 7 is already well established at CERN – it is used by a large majority of users. In fact, there was a considerable user demand even before its official release in October 2009 and its adoption has been smooth. Users praise Windows 7 for its improved stability and a clear advantage on laptops is a much more efficient implementation of offline files. The migration to Windows 7 involves a reinstallation of the operating system. Files stored in user home folders on DFS will be immediately available after the reinstallation. Applications will be upgraded to more recent versions and in certain cases, an application may even be replaced by another application providing the same functionality. Microsoft Office suite is a good ...

Thermal bridges of modern windows

DEFF Research Database (Denmark)

Hansen, Ernst Jan de Place; Møller, Eva B.; Nielsen, Anker

2013-01-01

if the window has an U-factor of 1 W/(m2·K) or lower. This paper describes the development of modern, energy efficient Danish windows with reduced thermal bridges. It focuses on materials, geometry, and sealing of window panes based on a literature review. Examples of modern windows are presented. Experience...... been an important driver for the development of new window solutions in Denmark, increasing the inner-surface temperature at the sealing of window panes. However, it will not stop complaints fromconsumers, as this temperature is calculated under standardized conditions. Increasing requirements...

Comparing speed of Web Map Service with GeoServer on ESRI Shapefile and PostGIS

Directory of Open Access Journals (Sweden)

Jan Růžička

2016-07-01

Full Text Available There are several options how to configure Web Map Service using severalmap servers. GeoServer is one of most popular map servers nowadays.GeoServer is able to read data from several sources. Very popular datasource is ESRI Shapefile. It is well documented and most of softwarefor geodata processing is able to read and write data in this format.Another very popular data store is PostgreSQL/PostGIS object-relationaldatabase. Both data sources has advantages and disadvantages and userof GeoServer has to decide which one to use. The paper describescomparison of performance of GeoServer Web Map Service when readingdata from ESRI Shapefile or from PostgreSQL/PostGIS database.

Comparison of Abbott AxSYM and Roche Elecsys 2010 for measurement of BNP and NT-proBNP.

Science.gov (United States)

Chien, Tzu-I; Chen, Hui-Hou; Kao, Jau-Tsuen

2006-07-15

B-type natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are small cardiac hormones released from the heart. They can be used as an important aid to diagnose congestive heart failure (CHF). We compared the performances of the Abbott AxSYM and Roche Elecsys 2010 for the measurement of BNP and NT-proBNP. The first method uses a microparticle enzyme-linked immunoassay, whereas the other uses chemiluminescent immunometric assay. The CVs using pooled sera ranged from 3.7% to 12.7% for the AxSYM and 0.9% to 2.2% for the Elecsys 2010. The Passing and Bablok regression was Elecsys 2010 NT-proBNP=7.23xAxSYM BNP+2.53. The BNP in EDTA plasma was more stable than in serum. The immunoreactivity difference of NT-proBNP in serum or EDTA plasma was within 10% when stored at 4 degrees Celsius or 25 degrees Celsius for 72 h. Receiver operating characteristic (ROC) curves were different for both assays, and the areas under the curves were 0.704 and 0.841 for the AxSYM and Elecsys 2010 method, respectively. Both assays were not entirely specific for heart failure. The precision and stability for NT-proBNP was better than for BNP in serum. It is important to use method-appropriate reference ranges (or cutoff) for the BNP and NT-proBNP, respectively, in the assessment of CHF.

Design heuristic for parallel many server systems under FCFS-ALIS

NARCIS (Netherlands)

Adan, I.J.B.F.; Boon, M.; Weiss, G.

2016-01-01

We study a parallel service queueing system with servers of types $s_1,\\ldots,s_J$, customers of types $c_1,\\ldots,c_I$, bipartite compatibility graph $\\mathcal{G}$, where arc $(c_i, s_j)$ indicates that server type $s_j$ can serve customer type $c_i$, and service policy of first come first served

Design and Delivery of Multiple Server-Side Computer Languages Course

Science.gov (United States)

Wang, Shouhong; Wang, Hai

2011-01-01

Given the emergence of service-oriented architecture, IS students need to be knowledgeable of multiple server-side computer programming languages to be able to meet the needs of the job market. This paper outlines the pedagogy of an innovative course of multiple server-side computer languages for the undergraduate IS majors. The paper discusses…

Usage of Thin-Client/Server Architecture in Computer Aided Education

Science.gov (United States)

Cimen, Caghan; Kavurucu, Yusuf; Aydin, Halit

2014-01-01

With the advances of technology, thin-client/server architecture has become popular in multi-user/single network environments. Thin-client is a user terminal in which the user can login to a domain and run programs by connecting to a remote server. Recent developments in network and hardware technologies (cloud computing, virtualization, etc.)…

Instant SQL Server Analysis Services 2012 Cube Security