Theoretical Interpretation of Pass 8 Fermi-LAT e + + e - Data

Science.gov (United States)

Di Mauro, M.; Manconi, S.; Vittino, A.; Donato, F.; Fornengo, N.; Baldini, L.; Bonino, R.; Di Lalla, N.; Latronico, L.; Maldera, S.; Manfreda, A.; Negro, M.; Pesce-Rollins, M.; Sgrò, C.; Spada, F.

2017-08-01

The flux of positrons and electrons (e + + e -) has been measured by the Fermi Large Area Telescope (LAT) in the energy range between 7 GeV and 2 TeV. We discuss a number of interpretations of Pass 8 Fermi-LAT e + + e - spectrum, combining electron and positron emission from supernova remnants (SNRs) and pulsar wind nebulae (PWNe), or produced by the collision of cosmic rays (CRs) with the interstellar medium. We find that the Fermi-LAT spectrum is compatible with the sum of electrons from a smooth SNR population, positrons from cataloged PWNe, and a secondary component. If we include in our analysis constraints from the AMS-02 positron spectrum, we obtain a slightly worse fit to the e + + e - Fermi-LAT spectrum, depending on the propagation model. As an additional scenario, we replace the smooth SNR component within 0.7 kpc with the individual sources found in Green’s catalog of Galactic SNRs. We find that separate consideration of far and near sources helps to reproduce the e + + e - Fermi-LAT spectrum. However, we show that the fit degrades when the radio constraints on the positron emission from Vela SNR (which is the main contributor at high energies) are taken into account. We find that a break in the power-law injection spectrum at about 100 GeV can also reproduce the measured e + + e - spectrum and, among the CR propagation models that we consider, no reasonable break of the power-law dependence of the diffusion coefficient can modify the electron flux enough to reproduce the observed shape.

A STACKED ANALYSIS OF 115 PULSARS OBSERVED BY THE FERMI LAT

Energy Technology Data Exchange (ETDEWEB)

McCann, A., E-mail: mccann@kicp.uchicago.edu [Kavli Institute for Cosmological Physics, University of Chicago 933 East 56th Street, Chicago, IL 60637 (United States)

2015-05-10

Due to the low gamma-ray fluxes from pulsars above 50 GeV and the small collecting area of space-based telescopes, the gamma-ray emission discovered by the Fermi Large Area Telescope (LAT) in ∼150 pulsars is largely unexplored at these energies. In this regime, the uncertainties on the spectral data points and/or the constraints from upper limits are not sufficient to provide robust tests of competing emission models in individual pulsars. The discovery of power-law-type emission from the Crab pulsar at energies exceeding 100 GeV provides a compelling justification for exploration of other pulsars at these energies. We applied the method of aperture photometry to measure pulsar emission spectra from Fermi-LAT data and present a stacked analysis of 115 pulsars selected from the Second Fermi-LAT catalog of gamma-ray pulsars. This analysis, which uses an average of ∼4.2 yr of data per pulsar, aggregates low-level emission which cannot be resolved in individual objects but can be detected in an ensemble. We find no significant stacked excess at energies above 50 GeV. An upper limit of 30% of the Crab pulsar level is found for the average flux from 115 pulsars in the 100–177 GeV energy range at the 95% confidence level. Stacked searches exclusive to the young pulsar sample, the millisecond pulsar sample, and several other promising sub-samples also return no significant excesses above 50 GeV.

Fermi-LAT Gamma-Ray Bursts and Insights from Swift

Science.gov (United States)

Racusin, Judith L.

2010-01-01

A new revolution in Gamma-ray Burst (GRB) observations and theory has begun over the last two years since the launch of the Fermi Gamma-ray Space Telescope. The new window into high energy gamma-rays opened by the Fermi-Large Area Telescope (LAT) is providing insight into prompt emission mechanisms and possibly also afterglow physics. The LAT detected GRBs appear to be a new unique subset of extremely energetic and bright bursts compared to the large sample detected by Swift over the last 6 years. In this talk, I will discuss the context and recent discoveries from these LAT GRBs and the large database of broadband observations collected by the Swift X-ray Telescope (XRT) and UV/Optical Telescope (UVOT). Through comparisons between the GRBs detected by Swift-BAT, G8M, and LAT, we can learn about the unique characteristics, physical differences, and the relationships between each population. These population characteristics provide insight into the different physical parameters that contribute to the diversity of observational GRB properties.

Weak light emission of soft tissues induced by heating

Science.gov (United States)

Spinelli, Antonello E.; Durando, Giovanni; Boschi, Federico

2018-04-01

The main goal of this work is to show that soft tissue interaction with high-intensity focused ultrasound (HIFU) or direct heating leads to a weak light emission detectable using a small animal optical imaging system. Our results show that the luminescence signal is detectable after 30 min of heating, resembling the time scale of delayed luminescence. The imaging of a soft tissue after heating it using an HIFU field shows that the luminescence pattern closely matches the shape of the cone typical of the HIFU beam. We conclude that heating a soft tissue using two different sources leads to the emission of a weak luminescence signal from the heated region with a decay half-life of a few minutes (4 to 6 min). The origin of such light emission needs to be further investigated.

The First Fermi-LAT Gamma-Ray Burst Catalog

NARCIS (Netherlands)

Ackermann, M.; et al., [Unknown; van der Horst, A.J.

2013-01-01

In three years of observations since the beginning of nominal science operations in 2008 August, the Large Area Telescope (LAT) on board the Fermi Gamma-Ray Space Telescope has observed high-energy (gsim 20 MeV) γ-ray emission from 35 gamma-ray bursts (GRBs). Among these, 28 GRBs have been detected

Fermi -LAT Observations of High-energy Behind-the-limb Solar Flares

Energy Technology Data Exchange (ETDEWEB)

Ackermann, M.; Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Allafort, A.; Bottacini, E.; Cameron, R. A.; Charles, E. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Baldini, L. [Università di Pisa and Istituto Nazionale di Fisica Nucleare, Sezione di Pisa I-56127 Pisa (Italy); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bissaldi, E.; Caragiulo, M.; Costanza, F. [Istituto Nazionale di Fisica Nucleare, Sezione di Bari, I-70126 Bari (Italy); Bonino, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, I-10125 Torino (Italy); Bregeon, J. [Laboratoire Univers et Particules de Montpellier, Université Montpellier, CNRS/IN2P3, F-34095 Montpellier (France); Bruel, P. [Laboratoire Leprince-Ringuet, École polytechnique, CNRS/IN2P3, F-91128 Palaiseau (France); Caraveo, P. A. [INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano, via E. Bassini 15, I-20133 Milano (Italy); Cavazzuti, E.; Ciprini, S. [Agenzia Spaziale Italiana (ASI) Science Data Center, I-00133 Roma (Italy); Cecchi, C., E-mail: nicola.omodei@stanford.edu, E-mail: vahep@stanford.edu, E-mail: melissa.pesce.rollins@pi.infn.it [Istituto Nazionale di Fisica Nucleare, Sezione di Perugia, I-06123 Perugia (Italy); and others

2017-02-01

We report on the Fermi -LAT detection of high-energy emission from the behind-the-limb (BTL) solar flares that occurred on 2013 October 11, and 2014 January 6 and September 1. The Fermi -LAT observations are associated with flares from active regions originating behind both the eastern and western limbs, as determined by STEREO . All three flares are associated with very fast coronal mass ejections (CMEs) and strong solar energetic particle events. We present updated localizations of the >100 MeV photon emission, hard X-ray (HXR) and EUV images, and broadband spectra from 10 keV to 10 GeV, as well as microwave spectra. We also provide a comparison of the BTL flares detected by Fermi -LAT with three on-disk flares and present a study of some of the significant quantities of these flares as an attempt to better understand the acceleration mechanisms at work during these occulted flares. We interpret the HXR emission to be due to electron bremsstrahlung from a coronal thin-target loop top with the accelerated electron spectra steepening at semirelativistic energies. The >100 MeV gamma-rays are best described by a pion-decay model resulting from the interaction of protons (and other ions) in a thick-target photospheric source. The protons are believed to have been accelerated (to energies >10 GeV) in the CME environment and precipitate down to the photosphere from the downstream side of the CME shock and landed on the front side of the Sun, away from the original flare site and the HXR emission.

THE FIRST FERMI LAT SUPERNOVA REMNANT CATALOG

Energy Technology Data Exchange (ETDEWEB)

Acero, F.; Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d’Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Ackermann, M.; Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Ajello, M. [Department of Physics and Astronomy, Clemson University, Kinard Lab of Physics, Clemson, SC 29634-0978 (United States); Baldini, L. [Università di Pisa and Istituto Nazionale di Fisica Nucleare, Sezione di Pisa I-56127 Pisa (Italy); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D.; Buson, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bissaldi, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Bari, I-70126 Bari (Italy); Blandford, R. D.; Bloom, E. D.; Bottacini, E.; Caliandro, G. A.; Cameron, R. A. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Bonino, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, I-10125 Torino (Italy); Brandt, T. J. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Bregeon, J. [Laboratoire Univers et Particules de Montpellier, Université Montpellier, CNRS/IN2P3, Montpellier (France); Bruel, P., E-mail: francesco.depalma@ba.infn.it, E-mail: t.j.brandt@nasa.gov, E-mail: john.w.hewitt@unf.edu [Laboratoire Leprince-Ringuet, École polytechnique, CNRS/IN2P3, Palaiseau (France); and others

2016-05-01

To uniformly determine the properties of supernova remnants (SNRs) at high energies, we have developed the first systematic survey at energies from 1 to 100 GeV using data from the Fermi Large Area Telescope (LAT). Based on the spatial overlap of sources detected at GeV energies with SNRs known from radio surveys, we classify 30 sources as likely GeV SNRs. We also report 14 marginal associations and 245 flux upper limits. A mock catalog in which the positions of known remnants are scrambled in Galactic longitude allows us to determine an upper limit of 22% on the number of GeV candidates falsely identified as SNRs. We have also developed a method to estimate spectral and spatial systematic errors arising from the diffuse interstellar emission model, a key component of all Galactic Fermi LAT analyses. By studying remnants uniformly in aggregate, we measure the GeV properties common to these objects and provide a crucial context for the detailed modeling of individual SNRs. Combining our GeV results with multiwavelength (MW) data, including radio, X-ray, and TeV, we demonstrate the need for improvements to previously sufficient, simple models describing the GeV and radio emission from these objects. We model the GeV and MW emission from SNRs in aggregate to constrain their maximal contribution to observed Galactic cosmic rays.

The GLAST LAT Instrument Science Operations Center

International Nuclear Information System (INIS)

Cameron, Robert A.; SLAC

2007-01-01

The Gamma-ray Large Area Space Telescope (GLAST) is scheduled for launch in late 2007. Operations support and science data processing for the Large Area Telescope (LAT) instrument on GLAST will be provided by the LAT Instrument Science Operations Center (ISOC) at the Stanford Linear Accelerator Center (SLAC). The ISOC supports GLAST mission operations in conjunction with other GLAST mission ground system elements and supports the research activities of the LAT scientific collaboration. The ISOC will be responsible for monitoring the health and safety of the LAT, preparing command loads for the LAT, maintaining embedded flight software which controls the LAT detector and data acquisition flight hardware, maintaining the operating configuration of the LAT and its calibration, and applying event reconstruction processing to down-linked LAT data to recover information about detected gamma-ray photons. The SLAC computer farm will be used to process LAT event data and generate science products, to be made available to the LAT collaboration through the ISOC and to the broader scientific community through the GLAST Science Support Center at NASA/GSFC. ISOC science operations will optimize the performance of the LAT and oversee automated science processing of LAT data to detect and monitor transient gamma-ray sources

Theoretical Interpretation of Pass 8 Fermi -LAT e {sup +} + e {sup −} Data

Energy Technology Data Exchange (ETDEWEB)

Di Mauro, M. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Manconi, S.; Donato, F.; Fornengo, N.; Bonino, R.; Negro, M. [Department of Physics, University of Torino, via P. Giuria 1, I-10125 Torino (Italy); Vittino, A. [Physik-Department T30D, Technische Universität München, James-Franck Straße 1, D-85748 Garching (Germany); Baldini, L.; Di Lalla, N.; Manfreda, A. [Università di Pisa and Istituto Nazionale di Fisica Nucleare, Sezione di Pisa I-56127 Pisa (Italy); Latronico, L.; Maldera, S. [Istituto Nazionale di Fisica Nucleare, via P. Giuria 1, I-10125 Torino (Italy); Pesce-Rollins, M.; Sgrò, C.; Spada, F. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy)

2017-08-20

The flux of positrons and electrons ( e {sup +} + e {sup −}) has been measured by the Fermi Large Area Telescope (LAT) in the energy range between 7 GeV and 2 TeV. We discuss a number of interpretations of Pass 8 Fermi -LAT e {sup +} + e {sup −} spectrum, combining electron and positron emission from supernova remnants (SNRs) and pulsar wind nebulae (PWNe), or produced by the collision of cosmic rays (CRs) with the interstellar medium. We find that the Fermi -LAT spectrum is compatible with the sum of electrons from a smooth SNR population, positrons from cataloged PWNe, and a secondary component. If we include in our analysis constraints from the AMS-02 positron spectrum, we obtain a slightly worse fit to the e {sup +} + e {sup −} Fermi -LAT spectrum, depending on the propagation model. As an additional scenario, we replace the smooth SNR component within 0.7 kpc with the individual sources found in Green’s catalog of Galactic SNRs. We find that separate consideration of far and near sources helps to reproduce the e {sup +} + e {sup −} Fermi -LAT spectrum. However, we show that the fit degrades when the radio constraints on the positron emission from Vela SNR (which is the main contributor at high energies) are taken into account. We find that a break in the power-law injection spectrum at about 100 GeV can also reproduce the measured e {sup +} + e {sup −} spectrum and, among the CR propagation models that we consider, no reasonable break of the power-law dependence of the diffusion coefficient can modify the electron flux enough to reproduce the observed shape.

FERMI-LAT DETECTION OF PULSED GAMMA-RAYS ABOVE 50 GeV FROM THE VELA PULSAR

Energy Technology Data Exchange (ETDEWEB)

Leung, Gene C. K.; Takata, J.; Ng, C. W.; Cheng, K. S. [Department of Physics, The University of Hong Kong, Pokfulam Road (Hong Kong); Kong, A. K. H.; Tam, P. H. T. [Institute of Astronomy and Department of Physics, National Tsing Hua University, Hsinchu, Taiwan (China); Hui, C. Y., E-mail: gene930@connect.hku.hk, E-mail: takata@hku.hk [Department of Astronomy and Space Science, Chungnam National University, Daejeon (Korea, Republic of)

2014-12-20

The first Fermi-Large Area Telescope (LAT) catalog of sources above 10 GeV reported evidence of pulsed emission above 25 GeV from 12 pulsars, including the Vela pulsar, which showed evidence of pulsation at >37 GeV energy bands. Using 62 months of Fermi-LAT data, we analyzed the gamma-ray emission from the Vela pulsar and searched for pulsed emission above 50 GeV. Having confirmed the significance of the pulsation in 30-50 GeV with the H test (p-value ∼10{sup –77}), we extracted its pulse profile using the Bayesian block algorithm and compared it with the distribution of the five observed photons above 50 GeV using the likelihood ratio test. Pulsation was significantly detected for photons above 50 GeV with a p-value of =3 × 10{sup –5} (4.2σ). The detection of pulsation is significant above 4σ at >79 GeV and above 3σ at >90 GeV energy bands, making this the highest energy pulsation significantly detected by the LAT. We explore the non-stationary outer gap scenario of the very high-energy emissions from the Vela pulsar.

Detailed investigation of the gamma-ray emission in the vicinity of SNR W28 with Fermi-LAT

Energy Technology Data Exchange (ETDEWEB)

Hanabata, Y. [Institute for Cosmic-Ray Research, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8582 (Japan); Katagiri, H. [College of Science, Ibaraki University, 2-1-1, Bunkyo, Mito 310-8512 (Japan); Hewitt, J.W. [CRESST, University of Maryland, Baltimore County, Baltimore, MD 21250 (United States); Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d' Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Fukazawa, Y. [Department of Physical Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Fukui, Y.; Hayakawa, T. [Department of Physics and Astrophysics, Nagoya University, Chikusa-ku Nagoya 464-8602 (Japan); Lemoine-Goumard, M. [Centre d' Études Nucléaires de Bordeaux Gradignan, IN2P3/CNRS, Université Bordeaux 1, BP120, F-33175 Gradignan Cedex (France); Pedaletti, G.; Torres, D. F. [Institut de Ciències de l' Espai (IEEE-CSIC), Campus UAB, 08193 Barcelona (Spain); Strong, A. W. [Max-Planck Institut für extraterrestrische Physik, D-85748 Garching (Germany); Yamazaki, R., E-mail: hanabata@icrr.u-tokyo.ac.jp, E-mail: katagiri@mx.ibaraki.ac.jp [Department of Physics and Mathematics, Aoyama Gakuin University, Sagamihara, Kanagawa 252-5258 (Japan)

2014-05-10

We present a detailed investigation of the γ-ray emission in the vicinity of the supernova remnant (SNR) W28 (G6.4–0.1) observed by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. We detected significant γ-ray emission spatially coincident with TeV sources HESS J1800–240A, B, and C, located outside the radio boundary of the SNR. Their spectra in the 2-100 GeV band are consistent with the extrapolation of the power-law spectra of the TeV sources. We also identified a new source of GeV emission, dubbed Source W, which lies outside the boundary of TeV sources and coincides with radio emission from the western part of W28. All of the GeV γ-ray sources overlap with molecular clouds in the velocity range from 0 to 20 km s{sup –1}. Under the assumption that the γ-ray emission toward HESS J1800–240A, B, and C comes from π{sup 0} decay due to the interaction between the molecular clouds and cosmic rays (CRs) escaping from W28, they can be naturally explained by a single model in which the CR diffusion coefficient is smaller than the theoretical expectation in the interstellar space. The total energy of the CRs escaping from W28 is constrained through the same modeling to be larger than ∼2 × 10{sup 49} erg. The emission from Source W can also be explained with the same CR escape scenario.

Detailed investigation of the gamma-ray emission in the vicinity of SNR W28 with Fermi-LAT

International Nuclear Information System (INIS)

Hanabata, Y.; Katagiri, H.; Hewitt, J.W.; Ballet, J.; Fukazawa, Y.; Fukui, Y.; Hayakawa, T.; Lemoine-Goumard, M.; Pedaletti, G.; Torres, D. F.; Strong, A. W.; Yamazaki, R.

2014-01-01

We present a detailed investigation of the γ-ray emission in the vicinity of the supernova remnant (SNR) W28 (G6.4–0.1) observed by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. We detected significant γ-ray emission spatially coincident with TeV sources HESS J1800–240A, B, and C, located outside the radio boundary of the SNR. Their spectra in the 2-100 GeV band are consistent with the extrapolation of the power-law spectra of the TeV sources. We also identified a new source of GeV emission, dubbed Source W, which lies outside the boundary of TeV sources and coincides with radio emission from the western part of W28. All of the GeV γ-ray sources overlap with molecular clouds in the velocity range from 0 to 20 km s –1 . Under the assumption that the γ-ray emission toward HESS J1800–240A, B, and C comes from π 0 decay due to the interaction between the molecular clouds and cosmic rays (CRs) escaping from W28, they can be naturally explained by a single model in which the CR diffusion coefficient is smaller than the theoretical expectation in the interstellar space. The total energy of the CRs escaping from W28 is constrained through the same modeling to be larger than ∼2 × 10 49 erg. The emission from Source W can also be explained with the same CR escape scenario.

Fermi-LAT View of Bright Flaring Gamma-Ray Blazars

Science.gov (United States)

Bastieri, D.; Ciprini, S.; Gasparrini, D.

2011-06-01

The Fermi LAT provides a continuous and uniform monitoring of the Universe in the gamma-ray band. During the first year many gamma-ray blazar flares, some unidentified transients and emission by the Sun while in a quiet state were promptly detected. This is mainly due to the design of the mission, featuring a detector, the LAT with a wide field of view, and to the operation of the spacecraft itself, that can cover every region of the sky every 3 hours. Nevertheless, the scientific exploitation of this monitoring is more fruitful when early information about transients reaches a broader community. In this respect, the indefatigable activity of flare advocates, who worked on weekly shifts to validate the results and quickly broadcast information about flares and new detections, was the key to most scientific results.

THE ULTRAVIOLET-TO-MID-INFRARED SPECTRAL ENERGY DISTRIBUTION OF WEAK EMISSION LINE QUASARS

International Nuclear Information System (INIS)

Lane, Ryan A.; Shemmer, Ohad; Diamond-Stanic, Aleksandar M.; Fan Xiaohui; Anderson, Scott F.; Brandt, W. N.; Schneider, Donald P.; Plotkin, Richard M.; Richards, Gordon T.; Strauss, Michael A.

2011-01-01

We present Spitzer Space Telescope photometry of 18 Sloan Digital Sky Survey (SDSS) quasars at 2.7 ≤ z ≤ 5.9 which have weak or undetectable high-ionization emission lines in their rest-frame ultraviolet (UV) spectra (hereafter weak-lined quasars, or WLQs). The Spitzer data are combined with SDSS spectra and ground-based, near-infrared (IR) photometry of these sources to produce a large inventory of spectral energy distributions (SEDs) of WLQs across the rest-frame ∼0.1-5 μm spectral band. The SEDs of our sources are inconsistent with those of BL Lacertae objects which are dominated by synchrotron emission due to a jet aligned close to our line of sight, but are consistent with the SED of ordinary quasars with similar luminosities and redshifts that exhibit a near-to-mid-IR 'bump', characteristic of hot dust emission. This indicates that broad emission lines in WLQs are intrinsically weak, rather than suffering continuum dilution from a jet, and that such sources cannot be selected efficiently from traditional photometric surveys.

THE ULTRAVIOLET-TO-MID-INFRARED SPECTRAL ENERGY DISTRIBUTION OF WEAK EMISSION LINE QUASARS

Energy Technology Data Exchange (ETDEWEB)

Lane, Ryan A.; Shemmer, Ohad [Department of Physics, University of North Texas, Denton, TX 76203 (United States); Diamond-Stanic, Aleksandar M. [Center for Astrophysics and Space Sciences, University of California, San Diego, La Jolla, CA 92093 (United States); Fan Xiaohui [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Anderson, Scott F. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Brandt, W. N.; Schneider, Donald P. [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802 (United States); Plotkin, Richard M. [Astronomical Institute ' Anton Pannekoek' , University of Amsterdam, Science Park 904, NL-1098 XH Amsterdam (Netherlands); Richards, Gordon T. [Department of Physics, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 (United States); Strauss, Michael A., E-mail: RyanLane@my.unt.edu, E-mail: ohad@unt.edu [Princeton University Observatory, Peyton Hall, Princeton, NJ 08544 (United States)

2011-12-20

We present Spitzer Space Telescope photometry of 18 Sloan Digital Sky Survey (SDSS) quasars at 2.7 {<=} z {<=} 5.9 which have weak or undetectable high-ionization emission lines in their rest-frame ultraviolet (UV) spectra (hereafter weak-lined quasars, or WLQs). The Spitzer data are combined with SDSS spectra and ground-based, near-infrared (IR) photometry of these sources to produce a large inventory of spectral energy distributions (SEDs) of WLQs across the rest-frame {approx}0.1-5 {mu}m spectral band. The SEDs of our sources are inconsistent with those of BL Lacertae objects which are dominated by synchrotron emission due to a jet aligned close to our line of sight, but are consistent with the SED of ordinary quasars with similar luminosities and redshifts that exhibit a near-to-mid-IR 'bump', characteristic of hot dust emission. This indicates that broad emission lines in WLQs are intrinsically weak, rather than suffering continuum dilution from a jet, and that such sources cannot be selected efficiently from traditional photometric surveys.

Ntal/Lab/Lat2

DEFF Research Database (Denmark)

Iwaki, Shoko; Jensen, Bettina M; Gilfillan, Alasdair M

2007-01-01

T cells. As demonstrated in monocytes and B cells, phosphorylated NTAL/LAB/LAT2 recruits signaling molecules such as Grb2, Gab1 and c-Cbl into receptor-signaling complexes. Although gene knock out and knock down studies have indicated that NTAL/LAB/LAT2 may function as both a positive and negative...

DETECTION OF REST-FRAME OPTICAL LINES FROM X-SHOOTER SPECTROSCOPY OF WEAK EMISSION-LINE QUASARS

International Nuclear Information System (INIS)

Plotkin, Richard M.; Gallo, Elena; Shemmer, Ohad; Trakhtenbrot, Benny; Anderson, Scott F.; Brandt, W. N.; Luo, Bin; Schneider, Donald P.; Fan, Xiaohui; Lira, Paulina; Richards, Gordon T.; Strauss, Michael A.; Wu, Jianfeng

2015-01-01

Over the past 15 yr, examples of exotic radio-quiet quasars with intrinsically weak or absent broad emission line regions (BELRs) have emerged from large-scale spectroscopic sky surveys. Here, we present spectroscopy of seven such weak emission line quasars (WLQs) at moderate redshifts (z = 1.4–1.7) using the X-shooter spectrograph, which provides simultaneous optical and near-infrared spectroscopy covering the rest-frame ultraviolet (UV) through optical. These new observations effectively double the number of WLQs with spectroscopy in the optical rest-frame, and they allow us to compare the strengths of (weak) high-ionization emission lines (e.g., C iv) to low-ionization lines (e.g., Mg ii, Hβ, Hα) in individual objects. We detect broad Hβ and Hα emission in all objects, and these lines are generally toward the weaker end of the distribution expected for typical quasars (e.g., Hβ has rest-frame equivalent widths ranging from 15–40 Å). However, these low-ionization lines are not exceptionally weak, as is the case for high-ionization lines in WLQs. The X-shooter spectra also display relatively strong optical Fe ii emission, Hβ FWHM ≲ 4000 km s −1 , and significant C iv blueshifts (≈1000–5500 km s −1 ) relative to the systemic redshift; two spectra also show elevated UV Fe ii emission, and an outflowing component to their (weak) Mg ii emission lines. These properties suggest that WLQs are exotic versions of “wind-dominated” quasars. Their BELRs either have unusual high-ionization components, or their BELRs are in an atypical photoionization state because of an unusually soft continuum

Fermi-LAT and Suzaku observations of the radio galaxy Centaurus B

International Nuclear Information System (INIS)

Katsuta, J.; Tanaka, Y. T.; Stawarz, Ł.; O’Sullivan, S. P.; Cheung, C. C.

2013-01-01

Centaurus B is a nearby radio galaxy positioned in the southern hemisphere close to the Galactic plane. Here, in this work, we present a detailed analysis of about 43 months of accumulated Fermi-LAT data of the γ-ray counterpart of the source initially reported in the 2nd Fermi-LAT catalog, and of newly acquired Suzaku X-ray data. We confirm its detection at GeV photon energies and analyze the extension and variability of the γ-ray source in the LAT dataset, in which it appears as a steady γ-ray emitter. The X-ray core of Centaurus B is detected as a bright source of a continuum radiation. We do not detect, however, any diffuse X-ray emission from the known radio lobes, with the provided upper limit only marginally consistent with the previously claimed ASCA flux. Two scenarios that connect the X-ray and γ-ray properties are considered. In the first one, we assume that the diffuse non-thermal X-ray emission component is not significantly below the derived Suzaku upper limit. In this case, modeling the inverse-Compton emission shows that the observed γ-ray flux of the source may in principle be produced within the lobes. This association would imply that efficient in-situ acceleration of the radiating electrons is occurring and that the lobes are dominated by the pressure from the relativistic particles. In the second scenario, with the diffuse X-ray emission well below the Suzaku upper limits, the lobes in the system are instead dominated by the magnetic pressure. In this case, the observed γ-ray flux is not likely to be produced within the lobes, but instead within the nuclear parts of the jet. In conclusion, by means of synchrotron self-Compton modeling, we show that this possibility could be consistent with the broad-band data collected for the unresolved core of Centaurus B, including the newly derived Suzaku spectrum.

Search for Gamma-Ray Emission from the Coma Cluster with Six Years of Fermi-LAT Data

Science.gov (United States)

Ackermann, M.; Ajello, M.; Albert, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.;

MULTIWAVELENGTH OBSERVATIONS OF RADIO-QUIET QUASARS WITH WEAK EMISSION LINES

International Nuclear Information System (INIS)

Plotkin, Richard M.; Anderson, Scott F.; MacLeod, Chelsea L.; Brandt, W. N.; Schneider, Donald P.; Diamond-Stanic, Aleksandar M.; Fan Xiaohui; Shemmer, Ohad

2010-01-01

We present radio and X-ray observations, as well as optical light curves, for a subset of 26 BL Lac candidates from the Sloan Digital Sky Survey (SDSS) lacking strong radio emission and with z < 2.2. Half of these 26 objects are shown to be stars, galaxies, or absorbed quasars. We conclude that the other 13 objects are active galactic nuclei (AGNs) with abnormally weak emission features; 10 of those 13 are definitively radio quiet, and, for those with available optical light curves, their level of optical flux variability is consistent with radio-quiet quasars. We cannot exclude the possibility that some of these 13 AGNs lie on the extremely radio-faint tail of the BL Lac distribution, but our study generally supports the notion that all BL Lac objects are radio-loud. These radio-quiet AGNs appear to have intrinsically weak or absent broad emission line regions (BELRs), and, based on their X-ray properties, we argue that some are low-redshift analogs to weak line quasars (WLQs). SDSS BL Lac searches are so far the only systematic surveys of the SDSS database capable of recovering such exotic low-redshift WLQs. There are 71 more z < 2.2 radio-quiet BL Lac candidates already identified in the SDSS, but not considered here, and many of those might be best unified with WLQs as well. Future studies combining low- and high-redshift WLQ samples will yield new insight on our understanding of the structure and formation of AGN BELRs.

Broad Line Radio Galaxies Observed with Fermi-LAT: The Origin of the GeV Gamma-Ray Emission

Energy Technology Data Exchange (ETDEWEB)

Kataoka, J.; /Waseda U., RISE; Stawarz, L.; /JAXA, Sagamihara /Jagiellonian U., Astron. Observ.; Takahashi, Y.; /Waseda U., RISE; Cheung, C.C.; /Natl. Acad. Sci. /Naval Research Lab, Wash., D.C.; Hayashida, M.; /SLAC /Stanford U., HEPL /KIPAC, Menlo Park; Grandi, P.; /Bologna Observ.; Burnett, T.H.; /Washington U., Seattle; Celotti, A.; /SISSA, Trieste; Fegan, S.J.; Fortin, P.; /Ecole Polytechnique; Maeda, K.; Nakamori, T.; /Waseda U., RISE; Taylor, G.B.; /New Mexico U.; Tosti, G.; /INFN, Perugia /Perugia U.; Digel, S.W.; /SLAC /Stanford U., HEPL /KIPAC, Menlo Park; McConville, W.; /NASA, Goddard /Maryland U.; Finke, J.; /Naval Research Lab, Wash., D.C.; D' Ammando, F.; /IASF, Palermo /INAF, Rome

2012-06-07

We report on a detailed investigation of the {gamma}-ray emission from 18 broad line radio galaxies (BLRGs) based on two years of Fermi Large Area Telescope (LAT) data. We confirm the previously reported detections of 3C 120 and 3C 111 in the GeV photon energy range; a detailed look at the temporal characteristics of the observed {gamma}-ray emission reveals in addition possible flux variability in both sources. No statistically significant {gamma}-ray detection of the other BLRGs was however found in the considered dataset. Though the sample size studied is small, what appears to differentiate 3C 111 and 3C 120 from the BLRGs not yet detected in {gamma}-rays is the particularly strong nuclear radio flux. This finding, together with the indications of the {gamma}-ray flux variability and a number of other arguments presented, indicate that the GeV emission of BLRGs is most likely dominated by the beamed radiation of relativistic jets observed at intermediate viewing angles. In this paper we also analyzed a comparison sample of high accretion-rate Seyfert 1 galaxies, which can be considered radio-quiet counterparts of BLRGs, and found none were detected in {gamma}-rays. A simple phenomenological hybrid model applied for the broad-band emission of the discussed radio-loud and radio-quiet type 1 active galaxies suggests that the relative contribution of the nuclear jets to the accreting matter is {ge} 1% on average for BLRGs, while {le} 0.1% for Seyfert 1 galaxies.

X-RAY AND MULTIWAVELENGTH INSIGHTS INTO THE NATURE OF WEAK EMISSION-LINE QUASARS AT LOW REDSHIFT

Energy Technology Data Exchange (ETDEWEB)

Wu Jianfeng; Brandt, W. N.; Schneider, Donald P. [Department of Astronomy and Astrophysics, Pennsylvania State University, 525 Davey Lab, University Park, PA 16802 (United States); Anderson, Scott F. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Diamond-Stanic, Aleksandar M. [Center for Astrophysics and Space Sciences, University of California, San Diego, La Jolla, CA 92903 (United States); Hall, Patrick B. [Department of Physics and Astronomy, York University, 4700 Keele Street, Toronto, ON M3J 1P3 (Canada); Plotkin, Richard M. [Astronomical Institute ' Anton Pannekoek' , University of Amsterdam, Science Park 904, 1098 XH Amsterdam (Netherlands); Shemmer, Ohad, E-mail: jfwu@astro.psu.edu [Department of Physics, University of North Texas, Denton, TX 76203 (United States)

2012-03-01

We report on the X-ray and multiwavelength properties of 11 radio-quiet quasars with weak or no emission lines identified by the Sloan Digital Sky Survey (SDSS) with redshift z = 0.4-2.5. Our sample was selected from the Plotkin et al. catalog of radio-quiet, weak-featured active galactic nuclei (AGNs). The distribution of relative X-ray brightness for our low-redshift weak-line quasar (WLQ) candidates is significantly different from that of typical radio-quiet quasars, having an excess of X-ray weak sources, but it is consistent with that of high-redshift WLQs. Over half of the low-redshift WLQ candidates are X-ray weak by a factor of {approx}> 5, compared to a typical SDSS quasar with similar UV/optical luminosity. These X-ray weak sources generally show similar UV emission-line properties to those of the X-ray weak quasar PHL 1811 (weak and blueshifted high-ionization lines, weak semiforbidden lines, and strong UV Fe emission); they may belong to the notable class of PHL 1811 analogs. The average X-ray spectrum of these sources is somewhat harder than that of typical radio-quiet quasars. Several other low-redshift WLQ candidates have normal ratios of X-ray-to-optical/UV flux, and their average X-ray spectral properties are also similar to those of typical radio-quiet quasars. The X-ray weak and X-ray normal WLQ candidates may belong to the same subset of quasars having high-ionization 'shielding gas' covering most of the wind-dominated broad emission-line region, but be viewed at different inclinations. The mid-infrared-to-X-ray spectral energy distributions (SEDs) of these sources are generally consistent with those of typical SDSS quasars, showing that they are not likely to be BL Lac objects with relativistically boosted continua and diluted emission lines. The mid-infrared-to-UV SEDs of most radio-quiet weak-featured AGNs without sensitive X-ray coverage (34 objects) are also consistent with those of typical SDSS quasars. However, one source in our

X-RAY AND MULTIWAVELENGTH INSIGHTS INTO THE NATURE OF WEAK EMISSION-LINE QUASARS AT LOW REDSHIFT

International Nuclear Information System (INIS)

Wu Jianfeng; Brandt, W. N.; Schneider, Donald P.; Anderson, Scott F.; Diamond-Stanic, Aleksandar M.; Hall, Patrick B.; Plotkin, Richard M.; Shemmer, Ohad

2012-01-01

We report on the X-ray and multiwavelength properties of 11 radio-quiet quasars with weak or no emission lines identified by the Sloan Digital Sky Survey (SDSS) with redshift z = 0.4-2.5. Our sample was selected from the Plotkin et al. catalog of radio-quiet, weak-featured active galactic nuclei (AGNs). The distribution of relative X-ray brightness for our low-redshift weak-line quasar (WLQ) candidates is significantly different from that of typical radio-quiet quasars, having an excess of X-ray weak sources, but it is consistent with that of high-redshift WLQs. Over half of the low-redshift WLQ candidates are X-ray weak by a factor of ∼> 5, compared to a typical SDSS quasar with similar UV/optical luminosity. These X-ray weak sources generally show similar UV emission-line properties to those of the X-ray weak quasar PHL 1811 (weak and blueshifted high-ionization lines, weak semiforbidden lines, and strong UV Fe emission); they may belong to the notable class of PHL 1811 analogs. The average X-ray spectrum of these sources is somewhat harder than that of typical radio-quiet quasars. Several other low-redshift WLQ candidates have normal ratios of X-ray-to-optical/UV flux, and their average X-ray spectral properties are also similar to those of typical radio-quiet quasars. The X-ray weak and X-ray normal WLQ candidates may belong to the same subset of quasars having high-ionization 'shielding gas' covering most of the wind-dominated broad emission-line region, but be viewed at different inclinations. The mid-infrared-to-X-ray spectral energy distributions (SEDs) of these sources are generally consistent with those of typical SDSS quasars, showing that they are not likely to be BL Lac objects with relativistically boosted continua and diluted emission lines. The mid-infrared-to-UV SEDs of most radio-quiet weak-featured AGNs without sensitive X-ray coverage (34 objects) are also consistent with those of typical SDSS quasars. However, one source in our X

Weak Hard X-Ray Emission from Broad Absorption Line Quasars: Evidence for Intrinsic X-Ray Weakness

DEFF Research Database (Denmark)

Luo, B.; Brandt, W. N.; Alexander, D. M.

2014-01-01

We report NuSTAR observations of a sample of six X-ray weak broad absorption line (BAL) quasars. These targets, at z = 0.148-1.223, are among the optically brightest and most luminous BAL quasars known at z 330 times weaker than...... expected for typical quasars. Our results from a pilot NuSTAR study of two low-redshift BAL quasars, a Chandra stacking analysis of a sample of high-redshift BAL quasars, and a NuSTAR spectral analysis of the local BAL quasar Mrk 231 have already suggested the existence of intrinsically X-ray weak BAL...... quasars, i.e., quasars not emitting X-rays at the level expected from their optical/UV emission. The aim of the current program is to extend the search for such extraordinary objects. Three of the six new targets are weakly detected by NuSTAR with ≲ 45 counts in the 3-24 keV band, and the other three...

Fermi-LAT observation of nonblazar AGNs

Science.gov (United States)

Sahakyan, N.; Baghmanyan, V.; Zargaryan, D.

2018-06-01

Context. Fermi Large Area Telescope (Fermi-LAT) has recently detected γ-ray emission from active galactic nuclei (AGN) that do not show clear evidence for optical blazar characteristics or have jets pointing away from the observer (nonblazar AGNs). These are interesting γ-ray emitters providing an alternative approach to studying high energy emission processes. Aims: This paper investigates the spectral and temporal properties of γ-ray emission from nonblazar AGNs using the recent Fermi-LAT observational data. Methods: The data collected by Fermi-LAT during 2008-2015, from the observations of 26 nonblazar AGNs, including 11 Fanaroff-Riley Type I (FRI) and ten FRII radio galaxies and steep spectrum radio quasars (SSRQs) and five narrow line seyfert 1s (NLSy1s) are analysed using the new PASS 8 event selection and instrument response function. Possible spectral changes above GeV energies are investigated with a detailed spectral analysis. Light curves generated with normal and adaptive time bins are used to study the γ-ray flux variability. Results: Non-blazar AGNs have a γ-ray photon index in the range of 1.84-2.86 and a flux varying from a few times 10-9 photon cm-2 s-1 to 10-7 photon cm-2 s-1. Over long time periods, the power law provides an adequate description of the γ-ray spectra of almost all sources. Significant curvature is observed in the γ-ray spectra of NGC 1275, NGC 6251, SBS 0846 + 513, and PMN J0948 + 0022 and their spectra are better described by log parabola or by the power law with exponential cut-off models. The γ-ray spectra of PKS 0625-25 and 3C 380 show a possible deviation from a simple power-law shape, indicating a spectral cut-off around the observed photon energy of Ecut = 131.2 ± 88.04 GeV and Ecut = 55.57 ± 50.74 GeV, respectively. Our analysis confirms the previous finding of an unusual spectral turnover in the γ-ray spectrum of Cen A: the photon index changes from Γ = 2.75 ± 0.02 to 2.31 ± 0.1 at 2.35 ± 0.08 GeV. In the �

Tracking biochemical changes correlated with ultra-weak photon emission using metabolomics

Czech Academy of Sciences Publication Activity Database

Burgos, R.C.R.; Červinková, Kateřina; van der Laan, T.; Ramautar, R.; van Wijk, E.P.A.; Cifra, Michal; Koval, S.; Berger, R.; Hankemeier, T.; van der Greef, J.

-, č. 163 (2016), s. 237-245 ISSN 1011-1344 R&D Projects: GA ČR GA13-29294S Institutional support: RVO:67985882 Keywords : Ultra-weak photon emission * Capillary electrophoresis-mass spectrometry * HL-60 cells Subject RIV: BO - Biophysics Impact factor: 2.673, year: 2016

Detection of 16 Gamma-Ray Pulsars Through Blind Frequency Searches Using the Fermi LAT

International Nuclear Information System (INIS)

Anderson, B.; Atwood, W.B.; Dormody, M.; Johnson, R.P.; Porter, T.A.; Primack, J.R.; Sadrozinski, H.F.W.; Parkinson, P.M.S.; Ziegler, M.; Abdo, A.A.; Dermer, C.D.; Grove, J.E.; Gwon, C.; Johnson, W.N.; Lovellette, M.N.; Makeev, A.; Ray, P.S.; Strickman, M.S.; Wolff, M.T.; Wood, K.S.; Ackermann, M.; Ajello, M.; Bechtol, K.; Berenji, B.; Blandford, R.D.; Borgland, A.W.; Cameron, R.A.; Chiang, J.; Claus, R.; Digel, S.W.; Silva, E.D.E.; Drell, P.S.; Dubois, R.; Funk, S.; Glanzman, T.; Godfrey, G.; Hayashida, M.; Johannesson, G.; Kamae, T.; Kocian, M.L.; Lande, J.; Madejski, G.M.; Michelson, P.F.; Mitthumsiri, W.; Monzani, M.E.; Moskalenko, I.V.; Murgia, S.; Nolan, P.L.; Paneque, D.; Reimer, A.; Reimer, O.; Rochester, L.S.; Romani, R.W.; Tajima, H.; Tanaka, T.; Thayer, J.G.; Tramacere, A.; Uchiyama, Y.; Usher, T.L.; Van Etten, A.; Waite, A.P.; Wang, P.; Watters, K.; Ackermann, M.; Ajello, M.; Bechtol, K.; Berenji, B.; Bloom, E.D.; Borgland, A.W.; Cameron, R.A.; Chiang, J.; Claus, R.; Digel, S.W.; Silva, E.D.E.; Drell, P.S.; Dubois, R.; Glanzman, T.; Godfrey, G.; Hayashida, M.; Johannesson, G.; Kamae, T.; Kocian, M.L.; Lande, J.; Madejski, G.M.; Michelson, P.F.; Mitthumsiri, W.; Monzani, M.E.; Moskalenko, I.V.; Murgia, S.; Nolan, P.L.; Paneque, D.; Reimer, A.; Reimer, O.; Rochester, L.S.; Romani, R.W.; Tajima, H.; Tanaka, T.; Thayer, J.G.; Tramacere, A.; Uchiyama, Y.; Usher, T.L.; Van Etten, A.; Waite, A.P.; Wang, P.; Watters, K.; Axelsson, M.; Conrad, J.; Meurer, C.; Ryde, F.; Ylinen, T.; Axelsson, M.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Brez, A.; Kuss, M.; Latronico, L.; Omodei, N.; Pesce-Rollins, M.; Razzano, M.; Sgro, C.; Spandre, G.; Ballet, J.; Casandjian, J.M.; Grenier, I.A.; Pierbattista, M.; Starck, J.L.

2009-01-01

Pulsars are rapidly rotating, highly magnetized neutron stars emitting radiation across the electromagnetic spectrum. Although there are more than 1800 known radio pulsars, until recently only seven were observed to pulse in gamma rays, and these were all discovered at other wavelengths. The Fermi Large Area Telescope (LAT) makes it possible to pinpoint neutron stars through their gamma-ray pulsations. We report the detection of 16 gamma-ray pulsars in blind frequency searches using the LAT. Most of these pulsars are coincident with previously unidentified gamma-ray sources, and many are associated with supernova remnants. Direct detection of gamma-ray pulsars enables studies of emission mechanisms, population statistics, and the energetics of pulsar wind nebulae and supernova remnants. (authors)

Constraints on the Galactic Halo Dark Matter from Fermi-LAT Diffuse Measurements

Science.gov (United States)

Ackermann, M.; Ajello, M.; Atwood, W. B.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bloom, E. D.;

The GLAST Mission, LAT and GRBs

International Nuclear Information System (INIS)

Omodei, Nicola; INFN, Pisa

2006-01-01

The GLAST Large Area Telescope (LAT) is the next generation satellite experiment for high-energy gamma-ray astronomy. It is a pair conversion telescope built with a plastic anticoincidence shield, a segmented CsI electromagnetic calorimeter, and the largest silicon strip tracker ever built. It will cover the energy range from 30 MeV to 300 GeV, shedding light on many issues left open by its predecessor EGRET. One of the most exciting science topics is the detection and observation of gamma-ray bursts (GRBs). In this paper we present the work done so far by the GRB LAT science group in studying the performance of the LAT detector to observe GRBs.We report on the simulation framework developed by the group as well as on the science tools dedicated to GRBs data analysis. We present the LAT sensitivity to GRBs obtained with such simulations, and, finally, the general scheme of GRBs detection that will be adopted on orbit

Weak Hard X-Ray Emission from Two Broad Absorption Line Quasars Observed with NuStar: Compton-Thick Absorption or Intrinsic X-Ray Weakness?

Science.gov (United States)

Luo, B.; Brandt, W. N.; Alexander, D. M.; Harrison, F. A.; Stern, D.; Bauer, F. E.; Boggs, S. E.; Christensen, F. E.; Comastri, A.; Craig, W. W..;

WEAK HARD X-RAY EMISSION FROM TWO BROAD ABSORPTION LINE QUASARS OBSERVED WITH NuSTAR: COMPTON-THICK ABSORPTION OR INTRINSIC X-RAY WEAKNESS?

Energy Technology Data Exchange (ETDEWEB)

Luo, B.; Brandt, W. N. [Department of Astronomy and Astrophysics, 525 Davey Lab, The Pennsylvania State University, University Park, PA 16802 (United States); Alexander, D. M.; Hickox, R. [Department of Physics, Durham University, South Road, Durham DH1 3LE (United Kingdom); Harrison, F. A.; Fuerst, F.; Grefenstette, B. W.; Madsen, K. K. [Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Stern, D. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Bauer, F. E. [Departamento de Astronomia y Astrofisica, Pontificia Universidad Catolica de Chile, Casilla 306, Santiago 22 (Chile); Boggs, S. E.; Craig, W. W. [Space Sciences Laboratory, University of California, Berkeley, CA 94720 (United States); Christensen, F. E. [DTU Space-National Space Institute, Technical University of Denmark, Elektrovej 327, DK-2800 Lyngby (Denmark); Comastri, A. [INAF-Osservatorio Astronomico di Bologna, Via Ranzani 1, I-40127 Bologna (Italy); Fabian, A. C. [Institute of Astronomy, Madingley Road, Cambridge CB3 0HA (United Kingdom); Farrah, D. [Department of Physics, Virginia Tech, Blacksburg, VA 24061 (United States); Fiore, F. [Osservatorio Astronomico di Roma, via Frascati 33, I-00040 Monteporzio Catone (Italy); Hailey, C. J. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Matt, G. [Dipartimento di Matematica e Fisica, Universita degli Studi Roma Tre, via della Vasca Navale 84, I-00146 Roma (Italy); Ogle, P. [IPAC, California Institute of Technology, Mail Code 220-6, Pasadena, CA 91125 (United States); and others

2013-08-01

We present Nuclear Spectroscopic Telescope Array (NuSTAR) hard X-ray observations of two X-ray weak broad absorption line (BAL) quasars, PG 1004+130 (radio loud) and PG 1700+518 (radio quiet). Many BAL quasars appear X-ray weak, probably due to absorption by the shielding gas between the nucleus and the accretion-disk wind. The two targets are among the optically brightest BAL quasars, yet they are known to be significantly X-ray weak at rest-frame 2-10 keV (16-120 times fainter than typical quasars). We would expect to obtain Almost-Equal-To 400-600 hard X-ray ({approx}> 10 keV) photons with NuSTAR, provided that these photons are not significantly absorbed (N{sub H} {approx}< 10{sup 24} cm{sup -2}). However, both BAL quasars are only detected in the softer NuSTAR bands (e.g., 4-20 keV) but not in its harder bands (e.g., 20-30 keV), suggesting that either the shielding gas is highly Compton-thick or the two targets are intrinsically X-ray weak. We constrain the column densities for both to be N{sub H} Almost-Equal-To 7 Multiplication-Sign 10{sup 24} cm{sup -2} if the weak hard X-ray emission is caused by obscuration from the shielding gas. We discuss a few possibilities for how PG 1004+130 could have Compton-thick shielding gas without strong Fe K{alpha} line emission; dilution from jet-linked X-ray emission is one likely explanation. We also discuss the intrinsic X-ray weakness scenario based on a coronal-quenching model relevant to the shielding gas and disk wind of BAL quasars. Motivated by our NuSTAR results, we perform a Chandra stacking analysis with the Large Bright Quasar Survey BAL quasar sample and place statistical constraints upon the fraction of intrinsically X-ray weak BAL quasars; this fraction is likely 17%-40%.

Dark matter and pulsar model constraints from Galactic center Fermi/LAT γ-ray observations

Science.gov (United States)

Gordon, Chris; Macias, Oscar

2014-05-01

Employing Fermi/LAT γ-ray observations, several independent groups have found excess extended γ-ray emission at the Galactic center (GC). Both, annihilating dark matter (DM) or a population of ~ 103 unresolved millisecond pulsars (MSPs) are regarded as well motivated possible explanations. However, there is significant uncertainties in the diffuse Galactic background at the GC. We have performed a revaluation of these two models for the extended γ-ray source at the GC by accounting for the systematic uncertainties of the Galactic diffuse emission model. We also marginalize over point source and diffuse background parameters in the region of interest. We show that the excess emission is significantly more extended than a point source. We find that the DM (or pulsar population) signal is larger than the systematic errors and therefore proceed to determine the sectors of parameter space that provide an acceptable fit to the data. We found that a population of several thousand MSPs with parameters consistent with the average spectral shape of Fermi/LAT measured MSPs was able to fit the GC excess emission. For DM, we found that a pure τ+τ- annihilation channel is not a good fit to the data. But a mixture of τ+τ- and bb with a of order the thermal relic value and a DM mass of around 20 to 60 GeV provides an adequate fit.

Photocount statistics of ultra-weak photon emission from germinating mung bean

Czech Academy of Sciences Publication Activity Database

Rafieiolhosseini, N.; Poplová, Michaela; Sasanpour, P.; Rafii-Tabar, H.; Alhossaini, M.R.; Cifra, Michal

2016-01-01

Roč. 162, September (2016), s. 50-55 ISSN 1011-1344 R&D Projects: GA ČR GA13-29294S Institutional support: RVO:67985882 Keywords : Mung bean * PMT photomultiplier tube * Abbreviations UPE ultra-weak photon emission Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 2.673, year: 2016

New stage in high-energy gamma-ray studies with GAMMA-400 after Fermi-LAT

Directory of Open Access Journals (Sweden)

Topchiev N.P.

2017-01-01

Full Text Available Fermi-LAT has made a significant contribution to the study of high-energy gamma-ray diffuse emission and the observations of 3000 discrete sources. However, one third of all gamma-ray sources (both galactic and extragalactic are unidentified, the data on the diffuse gamma-ray emission should be clarified, and signatures of dark matter particles in the high-energy gamma-ray range are not observed up to now. GAMMA-400, the currently developing gamma-ray telescope, will have angular (∼0.01∘ at 100 GeV and energy (∼1% at 100 GeV resolutions in the energy range of 10–1000 GeV which are better than Fermi-LAT (as well as ground gamma-ray telescopes by a factor of 5–10. It will observe some regions of the Universe (such as the Galactic Center, Fermi Bubbles, Crab, Cygnus, etc. in a highly elliptic orbit (without shading the telescope by the Earth continuously for a long time. It will allow us to identify many discrete sources, to clarify the structure of extended sources, to specify the data on the diffuse emission, and to resolve gamma rays from dark matter particles.

Why do intimate partners live apart? Evidence on LAT relationships across Europe

Directory of Open Access Journals (Sweden)

Aart C. Liefbroer

2015-01-01

Full Text Available Background: Most research asks whether or not cohabitation has come to rival marriage. Little is known about the meaning of living apart together (LAT relationships, and whether LAT is an alternative to marriage and cohabitation or a dating relationship. Objective: We examine across Europe: (1 the prevalence of LAT, (2 the reasons for LAT, and (3 the correlates of (a LAT relationships vis-à-vis being single, married, or cohabiting, and (b different types of LAT union. Methods: Using Generations and Gender Survey data from ten Western and Eastern European countries, we present descriptive statistics about LATs and estimate multinominal logistic regression models to assess the correlates of being in different types of LAT unions. Results: LAT relationships are uncommon, but they are more common in Western than Eastern Europe. Most people in LAT unions intend to live together but are apart for practical reasons. LAT is more common among young people, those enrolled in higher education, people with liberal attitudes, highly educated people, and those who have previously cohabited or been married. Older people and divorced or widowed persons are more likely to choose LAT to maintain independence. Surprisingly, attitudinal and educational differences are more pronounced in Eastern Europe than in Western Europe. Conclusions: A tentative conclusion is that LAT is more often a stage in the union formation process than an alternative to marriage and cohabitation. Yet some groups do view LAT as substituting for marriage and cohabitation, and these groups differ between East and West. In Eastern Europe a cultural, highly educated elite seems to be the first to resist traditional marriage norms and embrace LAT (and cohabitation as alternative living arrangements, whereas this is less the case in Western Europe. In Western Europe, LAT unions are mainly an alternative for persons who have been married before or had children in a prior relationship.

Dark matter and pulsar model constraints from Galactic Center Fermi-LAT gamma-ray observations

Science.gov (United States)

Gordon, Chris; Macías, Oscar

2013-10-01

Employing Fermi-LAT gamma-ray observations, several independent groups have found excess extended gamma-ray emission at the Galactic Center (GC). Both annihilating dark matter (DM) or a population of ˜103 unresolved millisecond pulsars (MSPs) are regarded as well-motivated possible explanations. However, there are significant uncertainties in the diffuse galactic background at the GC. We have performed a revaluation of these two models for the extended gamma-ray source at the GC by accounting for the systematic uncertainties of the Galactic diffuse emission model. We also marginalize over point-source and diffuse background parameters in the region of interest. We show that the excess emission is significantly more extended than a point source. We find that the DM (or pulsar-population) signal is larger than the systematic errors and therefore proceed to determine the sectors of parameter space that provide an acceptable fit to the data. We find that a population of 1000-2000 MSPs with parameters consistent with the average spectral shape of Fermi-LAT measured MSPs is able to fit the GC excess emission. For DM, we find that a pure τ+τ- annihilation channel is not a good fit to the data. But a mixture of τ+τ- and bb¯ with a ⟨σv⟩ of order the thermal relic value and a DM mass of around 20 to 60 GeV provides an adequate fit.

Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy

Energy Technology Data Exchange (ETDEWEB)

Ohkawa, Mayumi [Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai 980-8578 (Japan); Ohno, Yoshiya [Laboratory of Immunobiology, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe-shi, Hyogo 650-8530 (Japan); Masuko, Kazue; Takeuchi, Akiko; Suda, Kentaro; Kubo, Akihiro; Kawahara, Rieko; Okazaki, Shogo [Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, 4-1 Kowakae 3-chome, Higashiosaka-shi, Osaka 577-8502 (Japan); Tanaka, Toshiyuki [Laboratory of Immunobiology, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe-shi, Hyogo 650-8530 (Japan); Saya, Hideyuki [Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8502 (Japan); Seki, Masayuki; Enomoto, Takemi [Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai 980-8578 (Japan); Yagi, Hideki [Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, 4-1 Kowakae 3-chome, Higashiosaka-shi, Osaka 577-8502 (Japan); Hashimoto, Yoshiyuki [Tohoku University, Sendai (Japan); Masuko, Takashi, E-mail: masuko@phar.kindai.ac.jp [Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, 4-1 Kowakae 3-chome, Higashiosaka-shi, Osaka 577-8502 (Japan)

2011-03-25

Highlights: {yields} We established LAT1 amino-acid transporter-disrupted DT40 cells. {yields} LAT1-disrupted cells showed slow growth and lost the oncogenicity. {yields} siRNA and mAb inhibited human tumor growth in vitro and in vivo. {yields} LAT1 is a promising target molecule for cancer therapy. -- Abstract: L-type amino-acid transporter 1 (LAT1) is the first identified light chain of CD98 molecule, disulfide-linked to a heavy chain of CD98. Following cDNA cloning of chicken full-length LAT1, we have constructed targeting vectors for the disruption of chicken LAT1 gene from genomic DNA of chicken LAT1 consisting of 5.4 kb. We established five homozygous LAT1-disrupted (LAT1{sup -/-}) cell clones, derived from a heterozygous LAT1{sup +/-} clone of DT40 chicken B cell line. Reactivity of anti-chicken CD98hc monoclonal antibody (mAb) with LAT1{sup -/-} DT40 cells was markedly decreased compared with that of wild-type DT40 cells. All LAT1{sup -/-} cells were deficient in L-type amino-acid transporting activity, although alternative-splice variant but not full-length mRNA of LAT1 was detected in these cells. LAT1{sup -/-} DT40 clones showed outstandingly slow growth in liquid culture and decreased colony-formation capacity in soft agar compared with wild-type DT40 cells. Cell-cycle analyses indicated that LAT1{sup -/-} DT40 clones have prolonged cell-cycle phases compared with wild-type or LAT1{sup +/-} DT40 cells. Knockdown of human LAT1 by small interfering RNAs resulted in marked in vitro cell-growth inhibition of human cancer cells, and in vivo tumor growth of HeLa cells in athymic mice was significantly inhibited by anti-human LAT1 mAb. All these results indicate essential roles of LAT1 in the cell proliferation and occurrence of malignant phenotypes and that LAT1 is a promising candidate as a molecular target of human cancer therapy.

Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy

International Nuclear Information System (INIS)

Ohkawa, Mayumi; Ohno, Yoshiya; Masuko, Kazue; Takeuchi, Akiko; Suda, Kentaro; Kubo, Akihiro; Kawahara, Rieko; Okazaki, Shogo; Tanaka, Toshiyuki; Saya, Hideyuki; Seki, Masayuki; Enomoto, Takemi; Yagi, Hideki; Hashimoto, Yoshiyuki; Masuko, Takashi

2011-01-01

Highlights: → We established LAT1 amino-acid transporter-disrupted DT40 cells. → LAT1-disrupted cells showed slow growth and lost the oncogenicity. → siRNA and mAb inhibited human tumor growth in vitro and in vivo. → LAT1 is a promising target molecule for cancer therapy. -- Abstract: L-type amino-acid transporter 1 (LAT1) is the first identified light chain of CD98 molecule, disulfide-linked to a heavy chain of CD98. Following cDNA cloning of chicken full-length LAT1, we have constructed targeting vectors for the disruption of chicken LAT1 gene from genomic DNA of chicken LAT1 consisting of 5.4 kb. We established five homozygous LAT1-disrupted (LAT1 -/- ) cell clones, derived from a heterozygous LAT1 +/- clone of DT40 chicken B cell line. Reactivity of anti-chicken CD98hc monoclonal antibody (mAb) with LAT1 -/- DT40 cells was markedly decreased compared with that of wild-type DT40 cells. All LAT1 -/- cells were deficient in L-type amino-acid transporting activity, although alternative-splice variant but not full-length mRNA of LAT1 was detected in these cells. LAT1 -/- DT40 clones showed outstandingly slow growth in liquid culture and decreased colony-formation capacity in soft agar compared with wild-type DT40 cells. Cell-cycle analyses indicated that LAT1 -/- DT40 clones have prolonged cell-cycle phases compared with wild-type or LAT1 +/- DT40 cells. Knockdown of human LAT1 by small interfering RNAs resulted in marked in vitro cell-growth inhibition of human cancer cells, and in vivo tumor growth of HeLa cells in athymic mice was significantly inhibited by anti-human LAT1 mAb. All these results indicate essential roles of LAT1 in the cell proliferation and occurrence of malignant phenotypes and that LAT1 is a promising candidate as a molecular target of human cancer therapy.

Deep view of the Large Magellanic Cloud with six years of Fermi -LAT observations

International Nuclear Information System (INIS)

Ackermann, M.

2016-01-01

Context. The nearby Large Magellanic Cloud (LMC) provides a rare opportunity of a spatially resolved view of an external star-forming galaxy in -rays. The LMC was detected at 0.1–100 GeV as an extended source with CGRO/EGRET and using early observations with the Fermi-LAT. The emission was found to correlate with massive star-forming regions and to be particularly bright towards 30 Doradus. Aims. Studies of the origin and transport of cosmic rays (CRs) in the Milky Way are frequently hampered by line-of-sight confusion and poor distance determination. The LMC offers a complementary way to address these questions by revealing whether and how the -ray emission is connected to specific objects, populations of objects, and structures in the galaxy. Methods. We revisited the -ray emission from the LMC using about 73 months of Fermi-LAT P7REP data in the 0.2–100 GeV range. We developed a complete spatial and spectral model of the LMC emission, for which we tested several approaches: a simple geometrical description, template-fitting, and a physically driven model for CR-induced interstellar emission. Results. In addition to identifying PSR J0540-6919 through its pulsations, we find two hard sources positionally coincident with plerion N 157B and supernova remnant N 132D, which were also detected at TeV energies with H.E.S.S. We detect an additional soft source that is currently unidentified. Extended emission dominates the total flux from the LMC. It consists of an extended component of about the size of the galaxy and additional emission from three to four regions with degree-scale sizes. If it is interpreted as CRs interacting with interstellar gas, the large-scale emission implies a large-scale population of ~1–100GeV CRs with a density of ~30% of the local Galactic value. On top of that, the three to four small-scale emission regions would correspond to enhancements of the CR density by factors 2 to 6 or higher, possibly more energetic and younger populations

Linoleic Acid-Induced Ultra-Weak Photon Emission from Chlamydomonas reinhardtii as a Tool for Monitoring of Lipid Peroxidation in the Cell Membranes

Science.gov (United States)

Prasad, Ankush; Pospíšil, Pavel

2011-01-01

Reactive oxygen species formed as a response to various abiotic and biotic stresses cause an oxidative damage of cellular component such are lipids, proteins and nucleic acids. Lipid peroxidation is considered as one of the major processes responsible for the oxidative damage of the polyunsaturated fatty acid in the cell membranes. Various methods such as a loss of polyunsaturated fatty acids, amount of the primary and the secondary products are used to monitor the level of lipid peroxidation. To investigate the use of ultra-weak photon emission as a non-invasive tool for monitoring of lipid peroxidation, the involvement of lipid peroxidation in ultra-weak photon emission was studied in the unicellular green alga Chlamydomonas reinhardtii. Lipid peroxidation initiated by addition of exogenous linoleic acid to the cells was monitored by ultra-weak photon emission measured with the employment of highly sensitive charged couple device camera and photomultiplier tube. It was found that the addition of linoleic acid to the cells significantly increased the ultra-weak photon emission that correlates with the accumulation of lipid peroxidation product as measured using thiobarbituric acid assay. Scavenging of hydroxyl radical by mannitol, inhibition of intrinsic lipoxygenase by catechol and removal of molecular oxygen considerably suppressed ultra-weak photon emission measured after the addition of linoleic acid. The photon emission dominated at the red region of the spectrum with emission maximum at 680 nm. These observations reveal that the oxidation of linoleic acid by hydroxyl radical and intrinsic lipoxygenase results in the ultra-weak photon emission. Electronically excited species such as excited triplet carbonyls are the likely candidates for the primary excited species formed during the lipid peroxidation, whereas chlorophylls are the final emitters of photons. We propose here that the ultra-weak photon emission can be used as a non-invasive tool for the

Public List of LAT-Detected Gamma-Ray Pulsars

Data.gov (United States)

National Aeronautics and Space Administration — The following is a compilation of all publicly-announced gamma-ray pulsars detected using the Fermi LAT. Each of the detections has been vetted by the LAT team,...

A giant radio flare from Cygnus X-3 with associated γ-ray emission

Science.gov (United States)

Corbel, S.; Dubus, G.; Tomsick, J. A.; Szostek, A.; Corbet, R. H. D.; Miller-Jones, J. C. A.; Richards, J. L.; Pooley, G.; Trushkin, S.; Dubois, R.; Hill, A. B.; Kerr, M.; Max-Moerbeck, W.; Readhead, A. C. S.; Bodaghee, A.; Tudose, V.; Parent, D.; Wilms, J.; Pottschmidt, K.

2012-04-01

With frequent flaring activity of its relativistic jets, Cygnus X-3 (Cyg X-3) is one of the most active microquasars and is the only Galactic black hole candidate with confirmed high-energy γ-ray emission, thanks to detections by Fermi Large Area Telescope (Fermi/LAT) and AGILE. In 2011, Cyg X-3 was observed to transit to a soft X-ray state, which is known to be associated with high-energy γ-ray emission. We present the results of a multiwavelength campaign covering a quenched state, when radio emission from Cyg X-3 is at its weakest and the X-ray spectrum is very soft. A giant (˜20 Jy) optically thin radio flare marks the end of the quenched state, accompanied by rising non-thermal hard X-rays. Fermi/LAT observations (E≥ 100 MeV) reveal renewed γ-ray activity associated with this giant radio flare, suggesting a common origin for all non-thermal components. In addition, current observations unambiguously show that the γ-ray emission is not exclusively related to the rare giant radio flares. A three-week period of γ-ray emission is also detected when Cyg X-3 was weakly flaring in radio, right before transition to the radio quenched state. No γ-rays are observed during the ˜1-month long quenched state, when the radio flux is weakest. Our results suggest transitions into and out of the ultrasoft X-ray (radio-quenched) state trigger γ-ray emission, implying a connection to the accretion process, and also that the γ-ray activity is related to the level of radio flux (and possibly shock formation), strengthening the connection to the relativistic jets.

Radio Detection of the Fermi-LAT Blind Search Millisecond Pulsar J1311-3430

Science.gov (United States)

Ray, P. S.; Ransom, S. M.; Cheung, C. C.; Giroletti, M.; Cognard, I.; Camilo, F.; Bhattacharyya, B.; Roy, J.; Romani, R. W.; Ferrara, E. C.; Guillemot, L.; Johnston, S.; Keith, M.; Kerr, M.; Kramer, M.; Pletsch, H. J.; Saz Parkinson, P. M.; Wood, K. S.

2013-01-01

We report the detection of radio emission from PSR J1311-3430, the first millisecond pulsar (MSP) discovered in a blind search of Fermi Large Area Telescope (LAT) gamma-ray data. We detected radio pulsations at 2 GHz, visible for delay in the radio pulses as the pulsar appears from eclipse and we speculate on possible mechanisms for the non-detections of the pulse at other orbital phases and observing frequencies.

Linoleic acid-induced ultra-weak photon emission from Chlamydomonas reinhardtii as a tool for monitoring of lipid peroxidation in the cell membranes.

Directory of Open Access Journals (Sweden)

Ankush Prasad

Full Text Available Reactive oxygen species formed as a response to various abiotic and biotic stresses cause an oxidative damage of cellular component such are lipids, proteins and nucleic acids. Lipid peroxidation is considered as one of the major processes responsible for the oxidative damage of the polyunsaturated fatty acid in the cell membranes. Various methods such as a loss of polyunsaturated fatty acids, amount of the primary and the secondary products are used to monitor the level of lipid peroxidation. To investigate the use of ultra-weak photon emission as a non-invasive tool for monitoring of lipid peroxidation, the involvement of lipid peroxidation in ultra-weak photon emission was studied in the unicellular green alga Chlamydomonas reinhardtii. Lipid peroxidation initiated by addition of exogenous linoleic acid to the cells was monitored by ultra-weak photon emission measured with the employment of highly sensitive charged couple device camera and photomultiplier tube. It was found that the addition of linoleic acid to the cells significantly increased the ultra-weak photon emission that correlates with the accumulation of lipid peroxidation product as measured using thiobarbituric acid assay. Scavenging of hydroxyl radical by mannitol, inhibition of intrinsic lipoxygenase by catechol and removal of molecular oxygen considerably suppressed ultra-weak photon emission measured after the addition of linoleic acid. The photon emission dominated at the red region of the spectrum with emission maximum at 680 nm. These observations reveal that the oxidation of linoleic acid by hydroxyl radical and intrinsic lipoxygenase results in the ultra-weak photon emission. Electronically excited species such as excited triplet carbonyls are the likely candidates for the primary excited species formed during the lipid peroxidation, whereas chlorophylls are the final emitters of photons. We propose here that the ultra-weak photon emission can be used as a non

Diffuse γ-ray emission from galactic pulsars

International Nuclear Information System (INIS)

Calore, F.; Di Mauro, M.; Donato, F.

2014-01-01

Millisecond pulsars (MSPs) are old fast-spinning neutron stars that represent the second most abundant source population discovered by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope (Fermi). As guaranteed γ-ray emitters, they might contribute non-negligibly to the diffuse emission measured at high latitudes by Fermi-LAT (i.e., the Isotropic Diffuse γ-Ray Background (IDGRB)), which is believed to arise from the superposition of several components of galactic and extragalactic origin. Additionally, γ-ray sources also contribute to the anisotropy of the IDGRB measured on small scales by Fermi-LAT. In this manuscript we aim to assess the contribution of the unresolved counterpart of the detected MSPs population to the IDGRB and the maximal fraction of the measured anisotropy produced by this source class. To this end, we model the MSPs' spatial distribution in the Galaxy and the γ-ray emission parameters by considering observational constraints coming from the Australia Telescope National Facility pulsar catalog and the Second Fermi-LAT Catalog of γ-ray pulsars. By simulating a large number of MSP populations through a Monte Carlo simulation, we compute the average diffuse emission and the anisotropy 1σ upper limit. We find that the emission from unresolved MSPs at 2 GeV, where the peak of the spectrum is located, is at most 0.9% of the measured IDGRB above 10° in latitude. The 1σ upper limit on the angular power for unresolved MSP sources turns out to be about a factor of 60 smaller than Fermi-LAT measurements above 30°. Our results indicate that this galactic source class represents a negligible contributor to the high-latitude γ-ray sky and confirm that most of the intensity and geometrical properties of the measured diffuse emission are imputable to other extragalactic source classes (e.g., blazars, misaligned active galactic nuclei, or star-forming galaxies). Nevertheless, because MSPs are more concentrated toward the

Spectroscopic and polarimetric study of radio-quiet weak emission line quasars

Science.gov (United States)

Kumar, Parveen; Chand, Hum; Gopal-Krishna; Srianand, Raghunathan; Stalin, Chelliah Subramonian; Petitjean, Patrick

2018-04-01

A small subset of optically selected radio-quiet QSOs with weak or no emission lines may turn out to be the elusive radio-quiet BL Lac objects, or simply be radio-quiet QSOs with an infant/shielded broad line region (BLR). High polarisation (p > 3-4%), a hallmark of BL Lacs, can be used to test whether some optically selected ‘radio-quiet weak emission line QSOs’ (RQWLQs) show a fractional polarisation high enough to qualify as radio-quiet analogues of BL Lac objects. To check this possibility, we have made optical spectral and polarisation measurements of a sample of 19 RQWLQs. Out of these, only 9 sources show a non-significant proper motion (hence very likely extragalactic) and only two of them are found to have p > 1%. For these two RQWLQs, namely J142505.59+035336.2 and J154515.77+003235.2, we found the highest polarization to be 1.59±0.53%, which is again too low to classify them as (radio-quiet) BL Lacs, although one may recall that even genuine BL Lacs sometimes appear weakly polarised. We also present a statistical comparison of the optical spectral index, for a sample of 45 RQWLQs with redshift-luminosity matched control samples of 900 QSOs and an equivalent sample of 120 blazars, assembled from the literature. The spectral index distribution of RQWLQs is found to differ, at a high significance level, from that of blazars. This, too, is consistent with the common view that the mechanism of the central engine in RQWLQs, as a population, is close to that operating in normal QSOs and the primary difference between them is related to the BLR.

Constraints on light WIMP candidates from the isotropic diffuse gamma-ray emission

International Nuclear Information System (INIS)

Arina, Chiara; Tytgat, Michel H.G.

2011-01-01

Motivated by the measurements reported by direct detection experiments, most notably DAMA, CDMS-II, CoGeNT and Xenon10/100, we study further the constraints that might be set on some light dark matter candidates, M DM ∼ few GeV, using the Fermi-LAT data on the isotropic gamma-ray diffuse emission. In particular, we consider a Dirac fermion singlet interacting through a new Z' gauge boson, and a scalar singlet S interacting through the Higgs portal. Both candidates are WIMP (Weakly Interacting Massive Particles), i.e. they have an annihilation cross-section in the pbarn range. Also they may both have a spin-independent elastic cross section on nucleons in the range required by direct detection experiments. Although being generic WIMP candidates, because they have different interactions with Standard Model particles, their phenomenology regarding the isotropic diffuse gamma-ray emission is quite distinct. In the case of the scalar singlet, the one-to-one correspondence between its annihilation cross-section and its spin-independent elastic scattering cross-section permits to express the constraints from the Fermi-LAT data in the direct detection exclusion plot, σ n 0 −M DM . Depending on the astrophysics, we argue that it is possible to exclude the singlet scalar dark matter candidate at 95% confidence level. The constraints on the Dirac singlet interacting through a Z' are comparatively weaker

LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells

Directory of Open Access Journals (Sweden)

Keitaro Hayashi

2016-11-01

Full Text Available L-type amino acid transporter 1 (LAT1, SLC7A5 incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers. However, the function of LAT1 in thymic carcinoma remains unknown. Here we demonstrate that LAT1 is a critical transporter for human thymic carcinoma cells. LAT1 was strongly expressed in human thymic carcinoma tissues. LAT1-specific inhibitor significantly suppressed leucine uptake and growth of Ty82 human thymic carcinoma cell lines, suggesting that thymic carcinoma takes advantage of LAT1 as a quality transporter and that LAT1-specific inhibitor might be clinically beneficial in therapy for thymic carcinoma.

CLUES on Fermi-LAT prospects for the extragalactic detection of μνSSM gravitino dark matter

Energy Technology Data Exchange (ETDEWEB)

Gómez-Vargas, G.A.; Muñoz, C.; Yepes, G. [Departamento de Física Teórica, Universidad Autónoma de Madrid, Cantoblanco, E-28049, Madrid (Spain); Fornasa, M.; Zandanel, F.; Prada, F. [Instituto de Astrofísica de Andalucía (CSIC), E-18008, Granada (Spain); Cuesta, A.J., E-mail: germanarturo.gomez@uam.es, E-mail: mattia@iaa.es, E-mail: fabio@iaa.es, E-mail: antonio.cuesta@yale.edu, E-mail: carlos.munnoz@uam.es, E-mail: fprada@iaa.es, E-mail: gustavo.yepes@uam.es [Yale Center for Astronomy and Astrophysics, Yale University, CT 06511, New Haven (United States)

2012-02-01

The μνSSM is a supersymmetric model that has been proposed to solve the problems generated by other supersymmetric extensions of the standard model of particle physics. Given that R-parity is broken in the μνSSM, the gravitino is a natural candidate for decaying dark matter since its lifetime becomes much longer than the age of the Universe. In this model, gravitino dark matter could be detectable through the emission of a monochromatic gamma ray in a two-body decay. We study the prospects of the Fermi-LAT telescope to detect such monochromatic lines in 5 years of observations of the most massive nearby extragalactic objects. The dark matter halo around the Virgo galaxy cluster is selected as a reference case, since it is associated to a particularly high signal-to-noise ratio and is located in a region scarcely affected by the astrophysical diffuse emission from the galactic plane. The simulation of both signal and background gamma-ray events is carried out with the Fermi Science Tools, and the dark matter distribution around Virgo is taken from a N-body simulation of the nearby extragalactic Universe, with constrained initial conditions provided by the CLUES project. We find that a gravitino with a mass range of 0.6–2 GeV, and with a lifetime range of about 3 × 10{sup 27}–2 × 10{sup 28} s would be detectable by the Fermi-LAT with a signal-to-noise ratio larger than 3. We also obtain that gravitino masses larger than about 4 GeV are already excluded in the μνSSM by Fermi-LAT data of the galactic halo.

Dark matter implications of Fermi-LAT measurement of anisotropies in the diffuse gamma-ray background

International Nuclear Information System (INIS)

Gómez-Vargas, G.A.; Cuoco, A.; Linden, T.; Sánchez-Conde, M.A.; Siegal-Gaskins, J.M.; Delahaye, T.; Fornasa, M.; Komatsu, E.

2014-01-01

The detailed origin of the diffuse gamma-ray background is still unknown. However, the contribution of unresolved sources is expected to induce small-scale anisotropies in this emission, which may provide a way to identify and constrain the properties of its contributors. Recent studies have predicted the contributions to the angular power spectrum (APS) from extragalactic and galactic dark matter (DM) annihilation or decay. The Fermi-LAT collaboration reported detection of angular power with a significance larger than 3σ in the energy range from 1 GeV to 10 GeV on 22 months of data (Ackermann et al., 2012 [2]). For these preliminary results the already published Fermi-LAT APS measurements (Ackermann et al., 2012 [2]) are compared to the accurate predictions for DM anisotropies from state-of-the-art cosmological simulations as presented in Fornasa et al. (2013) [1] to derive constraints on different DM candidates

Dark matter implications of Fermi-LAT measurement of anisotropies in the diffuse gamma-ray background

Energy Technology Data Exchange (ETDEWEB)

Gómez-Vargas, G.A., E-mail: germanarturo.gomez@uam.es [Departamento de Física Teórica, Universidad Autónoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Instituto de Física Teórica IFT-UAM/CSIC, Universidad Autónoma de Madrid, Cantoblanco, E-28049, Madrid (Spain); Istituto Nazionale di Fisica Nucleare, Sez. Roma Tor Vergata, Roma (Italy); Cuoco, A. [The Oskar Klein Centre for Cosmo Particle Physics, AlbaNova, SE-106 91 Stockholm (Sweden); Linden, T. [Department of Physics, University of California, Santa Cruz, CA 95064 (United States); Sánchez-Conde, M.A. [SLAC National Accelerator Laboratory and Kavli Institute for Particle Astrophysics and Cosmology, Menlo Park, CA 94025 (United States); Siegal-Gaskins, J.M. [California Institute of Technology, Pasadena, CA 91125 (United States); Delahaye, T. [LAPTh, Universit e de Savoie, CNRS, 9 chemin de Bellevue, BP110, F-74941 Annecy-le-Vieux Cedex (France); Institut d' Astrophysique de Paris, UMR 7095 – CNRS, Universit e Pierre and Marie Curie, 98 bis boulevard Arago, 75014 Paris (France); Instituto de Física Teórica IFT-UAM/CSIC, Universidad Autónoma de Madrid, Cantoblanco, E-28049, Madrid (Spain); Fornasa, M. [School of Physics and Astronomy, University of Nottingham, NG7 2RD Nottingham (United Kingdom); Komatsu, E. [Max-Planck-Institut fur Astrophysik, Karl-Schwarzschild Str. 1, 85741 Garching (Germany); Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), Todai Institutes for Advanced Study, the University of Tokyo, Kashiwa 277-8583 (Japan); Texas Cosmology Center and the Department of Astronomy, The University of Texas at Austin, 1 University Station, C1400, Austin, TX 78712 (United States); and others

2014-04-01

The detailed origin of the diffuse gamma-ray background is still unknown. However, the contribution of unresolved sources is expected to induce small-scale anisotropies in this emission, which may provide a way to identify and constrain the properties of its contributors. Recent studies have predicted the contributions to the angular power spectrum (APS) from extragalactic and galactic dark matter (DM) annihilation or decay. The Fermi-LAT collaboration reported detection of angular power with a significance larger than 3σ in the energy range from 1 GeV to 10 GeV on 22 months of data (Ackermann et al., 2012 [2]). For these preliminary results the already published Fermi-LAT APS measurements (Ackermann et al., 2012 [2]) are compared to the accurate predictions for DM anisotropies from state-of-the-art cosmological simulations as presented in Fornasa et al. (2013) [1] to derive constraints on different DM candidates.

New genetic variants of LATS1 detected in urinary bladder and colon cancer.

Science.gov (United States)

Saadeldin, Mona K; Shawer, Heba; Mostafa, Ahmed; Kassem, Neemat M; Amleh, Asma; Siam, Rania

2014-01-01

LATS1, the large tumor suppressor 1 gene, encodes for a serine/threonine kinase protein and is implicated in cell cycle progression. LATS1 is down-regulated in various human cancers, such as breast cancer, and astrocytoma. Point mutations in LATS1 were reported in human sarcomas. Additionally, loss of heterozygosity of LATS1 chromosomal region predisposes to breast, ovarian, and cervical tumors. In the current study, we investigated LATS1 genetic variations including single nucleotide polymorphisms (SNPs), in 28 Egyptian patients with either urinary bladder or colon cancers. The LATS1 gene was amplified and sequenced and the expression of LATS1 at the RNA level was assessed in 12 urinary bladder cancer samples. We report, the identification of a total of 29 variants including previously identified SNPs within LATS1 coding and non-coding sequences. A total of 18 variants were novel. Majority of the novel variants, 13, were mapped to intronic sequences and un-translated regions of the gene. Four of the five novel variants located in the coding region of the gene, represented missense mutations within the serine/threonine kinase catalytic domain. Interestingly, LATS1 RNA steady state levels was lost in urinary bladder cancerous tissue harboring four specific SNPs (16045 + 41736 + 34614 + 56177) positioned in the 5'UTR, intron 6, and two silent mutations within exon 4 and exon 8, respectively. This study identifies novel single-base-sequence alterations in the LATS1 gene. These newly identified variants could potentially be used as novel diagnostic or prognostic tools in cancer.

A LINGERING NON-THERMAL COMPONENT IN THE GAMMA-RAY BURST PROMPT EMISSION: PREDICTING GeV EMISSION FROM THE MeV SPECTRUM

International Nuclear Information System (INIS)

Basak, Rupal; Rao, A. R.

2013-01-01

The high-energy GeV emission of gamma-ray bursts (GRBs) detected by Fermi/LAT has a significantly different morphology compared to the lower energy MeV emission detected by Fermi/GBM. Though the late-time GeV emission is believed to be synchrotron radiation produced via an external shock, this emission as early as the prompt phase is puzzling. A meaningful connection between these two emissions can be drawn only by an accurate description of the prompt MeV spectrum. We perform a time-resolved spectroscopy of the Gamma-ray Burst Monitor (GBM) data of long GRBs with significant GeV emission, using a model consisting of two blackbodies and a power law. We examine in detail the evolution of the spectral components and find that GRBs with high GeV emission (GRB 090902B and GRB 090926A) have a delayed onset of the power-law component in the GBM spectrum, which lingers at the later part of the prompt emission. This behavior mimics the flux evolution in the Large Area Telescope (LAT). In contrast, bright GBM GRBs with an order of magnitude lower GeV emission (GRB 100724B and GRB 091003) show a coupled variability of the total and the power-law flux. Further, by analyzing the data for a set of 17 GRBs, we find a strong correlation between the power-law fluence in the MeV and the LAT fluence (Pearson correlation: r = 0.88 and Spearman correlation: ρ = 0.81). We demonstrate that this correlation is not influenced by the correlation between the total and the power-law fluences at a confidence level of 2.3σ. We speculate the possible radiation mechanisms responsible for the correlation

FERMI OBSERVATIONS OF HIGH-ENERGY GAMMA-RAY EMISSION FROM GRB 090217A

International Nuclear Information System (INIS)

Ackermann, M.; Ajello, M.; Bechtol, K.; Berenji, B.; Blandford, R. D.; Borgland, A. W.; Bouvier, A.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Brez, A.; Ballet, J.; Barbiellini, G.; Baring, M. G.; Bastieri, D.; Bhat, P. N.; Briggs, M. S.; Bissaldi, E.; Bonamente, E.; Brigida, M.

2010-01-01

The Fermi observatory is advancing our knowledge of gamma-ray bursts (GRBs) through pioneering observations at high energies, covering more than seven decades in energy with the two on-board detectors, the Large Area Telescope (LAT) and the Gamma-ray Burst Monitor (GBM). Here, we report on the observation of the long GRB 090217A which triggered the GBM and has been detected by the LAT with a significance greater than 9σ. We present the GBM and LAT observations and on-ground analyses, including the time-resolved spectra and the study of the temporal profile from 8 keV up to ∼1 GeV. All spectra are well reproduced by a Band model. We compare these observations to the first two LAT-detected, long bursts GRB 080825C and GRB 080916C. These bursts were found to have time-dependent spectra and exhibited a delayed onset of the high-energy emission, which are not observed in the case of GRB 090217A. We discuss some theoretical implications for the high-energy emission of GRBs.

Decreased expression of LATS1 is correlated with the progression and prognosis of glioma

Directory of Open Access Journals (Sweden)

Ji Tianhai

2012-08-01

Full Text Available Abstract Background LATS1 is a tumor suppressor genes implicated in the pathogenesis of certain types of tumors, but its role is not known in human glioma. Methods Using real-time PCR and immunohistochemistry, we detected the mRNA and protein expression of LATS1 in glioma. The effect of LATS1 on cell growth and invasion were investigated. Results We found that mRNA and protein of LATS1 expression is significantly downregulated in glioma compared with normal control brain tissues. Furthermore, reduced LATS1 expression was markedly negatively correlated with WHO grade and KPS (p Conclusion These results indicate that LATS1 is an important candidate tumor suppressor and its downregulated expression may contribute to glioma progression.

LAT Daily Lightcurve FITS Files

Data.gov (United States)

National Aeronautics and Space Administration — LAT data between 100 MeV and 10 GeV filtered for solar counts in 1-minute time bins, no energy binning, using light-bucket method. Contains exposure (cm^2 s)...

Ultra-weak photon emission as a non-invasive tool for monitoring of oxidative processes in the epidermal cells of human skin: comparative study on the dorsal and the palm side of the hand.

Science.gov (United States)

Rastogi, Anshu; Pospísil, Pavel

2010-08-01

All living organisms emit spontaneous ultra-weak photon emission as a result of cellular metabolic processes. Exposure of living organisms to exogenous factors results in oxidative processes and enhancement in ultra-weak photon emission. Here, hydrogen peroxide (H(2)O(2)), as a strongly oxidizing molecule, was used to induce oxidative processes and enhance ultra-weak photon emission in human hand skin. The presented work intends to compare both spontaneous and peroxide-induced ultra-weak photon emission from the epidermal cells on the dorsal and the palm side of the hand. A highly sensitive photomultiplier tube and a charge-coupled device camera were used to detect ultra-weak photon emission from human hand skin. Spontaneous ultra-weak photon emission from the epidermal cells on the dorsal side of the hand was 4 counts/s. Topical application of 500 mM H(2)O(2) to the dorsal side of the hand caused enhancement in ultra-weak photon emission to 40 counts/s. Interestingly, both spontaneous and peroxide-induced ultra-weak photon emission from the epidermal cells on the palm side of the hand were observed to increase twice their values, i.e. 8 and 80 counts/s, respectively. Similarly, the two-dimensional image of ultra-weak photon emission observed after topical application of H(2)O(2) to human skin reveals that photon emission from the palm side exceeds the photon emission from the dorsal side of the hand. The results presented indicate that the ultra-weak photon emission originating from the epidermal cells on the dorsal and the palm side of the hand is related to the histological structure of the human hand skin. Ultra-weak photon emission is shown as a non-destructive technique for monitoring of oxidative processes in the epidermal cells of the human hand skin and as a diagnostic tool for skin diseases.

Constraints on the pMSSM from LAT Observations of Dwarf Spheroidal Galaxies

Energy Technology Data Exchange (ETDEWEB)

Cotta, R.C.; /SLAC; Drlica-Wagner, A.; Murgia, S.; /SLAC /KIPAC, Menlo Park; Bloom, E.D.; Hewett, J.L.; Rizzo, T.G.; /SLAC

2012-03-15

We examine the ability for the Large Area Telescope (LAT) to constrain Minimal Supersymmetric Standard Model (MSSM) dark matter through a combined analysis of Milky Way dwarf spheroidal galaxies. We examine the Lightest Supersymmetric Particles (LSPs) for a set of {approx}71k experimentally valid supersymmetric models derived from the phenomenological-MSSM (pMSSM). We find that none of these models can be excluded at 95% confidence by the current analysis; nevertheless, many lie within the predicted reach of future LAT analyses. With two years of data, we find that the LAT is currently most sensitive to light LSPs (mLSP < 50 GeV) annihilating into {tau}-pairs and heavier LSPs annihilating into b{bar b}. Additionally, we find that future LAT analyses will be able to probe some LSPs that form a sub-dominant component of dark matter. We directly compare the LAT results to direct detection experiments and show the complementarity of these search methods.

Searching for Dark Matter Signatures in the GLAST LAT Electron Flux

Science.gov (United States)

Moiseev, Alexander; Profumo, Stefano

2008-01-01

We explored several viable scenarios of how LAT might observe DM, when the spectral feature is predicted to be observed in the HE electron flux It has been demonstrated elsewhere that LAT will be capable to detect HE electrons flux in energy range from 20 GeV to - 1 TeV with 520% energy resolution and good statistics If there is a DM-caused feature in the HE electron flux (in the range 20 GeV - 1 TeV), LAT will be the best current instrument to observe it!

LAT 2-year Point Source Catalog

Data.gov (United States)

National Aeronautics and Space Administration — The Fermi Gamma-ray Space Telescope (Fermi) Large Area Telescope (LAT) is a successor to EGRET, with greatly improved sensitivity, resolution, and energy range. This...

Anisotropies in the diffuse gamma-ray background from dark matter with Fermi LAT: A closer look

International Nuclear Information System (INIS)

Cuoco, A.; Sellerholm, A.; Conrad, J.; Hannestad, S.

2011-01-01

We perform a detailed study of the sensitivity to the anisotropies related to dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) as measured by the Fermi Large Area Telescope (Fermi LAT). For the first time, we take into account the effects of the Galactic foregrounds and use a realistic representation of the Fermi LAT. We implement an analysis pipeline which simulates Fermi LAT data sets starting from model maps of the Galactic foregrounds, the Fermi-resolved point sources, the extragalactic diffuse emission and the signal from DM annihilation. The effects of the detector are taken into account by convolving the model maps with the Fermi LAT instrumental response. We then use the angular power spectrum to characterize the anisotropy properties of the simulated data and to study the sensitivity to DM. We consider DM anisotropies of extragalactic origin and of Galactic origin (which can be generated through annihilation in the Milky Way substructures) as opposed to a background of anisotropies generated by sources of astrophysical origin, blazars for example. We find that with statistics from 5 yr of observation, Fermi is sensitive to a DM contribution at the level of 1–10 per cent of the measured IGRB depending on the DM mass m χ and annihilation mode. In terms of the thermally averaged cross-section <σAv>, this corresponds to ~10 –25 cm 3 s –1 , i.e. slightly above the typical expectations for a thermal relic, for low values of the DM mass m χ ≲ 100 GeV. As a result, the anisotropy method for DM searches has a sensitivity comparable to the usual methods based only on the energy spectrum and thus constitutes an independent and complementary piece of information in the DM puzzle.

The Fermi LAT Very Important Project (VIP) List of Active Galactic Nuclei

Science.gov (United States)

Thompson, David J.; Fermi Large Area Telescope Collaboration

2018-01-01

Using nine years of Fermi Gamma-ray Space Telescope Large Area Telescope (LAT) observations, we have identified 30 projects for Active Galactic Nuclei (AGN) that appear to provide strong prospects for significant scientific advances. This Very Important Project (VIP) AGN list includes AGNs that have good multiwavelength coverage, are regularly detected by the Fermi LAT, and offer scientifically interesting timing or spectral properties. Each project has one or more LAT scientists identified who are actively monitoring the source. They will be regularly updating the LAT results for these VIP AGNs, working together with multiwavelength observers and theorists to maximize the scientific return during the coming years of the Fermi mission. See https://confluence.slac.stanford.edu/display/GLAMCOG/VIP+List+of+AGNs+for+Continued+Study

Constraining the High-Energy Emission from Gamma-Ray Bursts with Fermi

Science.gov (United States)

Gehrels, Neil; Harding, A. K.; Hays, E.; Racusin, J. L.; Sonbas, E.; Stamatikos, M.; Guirec, S.

2012-01-01

We examine 288 GRBs detected by the Fermi Gamma-ray Space Telescope's Gamma-ray Burst Monitor (GBM) that fell within the field-of-view of Fermi's Large Area Telescope (LAT) during the first 2.5 years of observations, which showed no evidence for emission above 100 MeV. We report the photon flux upper limits in the 0.1-10 GeV range during the prompt emission phase as well as for fixed 30 s and 100 s integrations starting from the trigger time for each burst. We compare these limits with the fluxes that would be expected from extrapolations of spectral fits presented in the first GBM spectral catalog and infer that roughly half of the GBM-detected bursts either require spectral breaks between the GBM and LAT energy bands or have intrinsically steeper spectra above the peak of the nuF(sub v) spectra (E(sub pk)). In order to distinguish between these two scenarios, we perform joint GBM and LAT spectral fits to the 30 brightest GBM-detected bursts and find that a majority of these bursts are indeed softer above E(sub pk) than would be inferred from fitting the GBM data alone. Approximately 20% of this spectroscopic subsample show statistically significant evidence for a cut-off in their high-energy spectra, which if assumed to be due to gamma gamma attenuation, places limits on the maximum Lorentz factor associated with the relativistic outflow producing this emission. All of these latter bursts have maximum Lorentz factor estimates that are well below the minimum Lorentz factors calculated for LAT-detected GRBs, revealing a wide distribution in the bulk Lorentz factor of GRB outflows and indicating that LAT-detected bursts may represent the high end of this distribution.

Pulsar Emission Geometry and Accelerating Field Strength

Science.gov (United States)

DeCesar, Megan E.; Harding, Alice K.; Miller, M. Coleman; Kalapotharakos, Constantinos; Parent, Damien

2012-01-01

The high-quality Fermi LAT observations of gamma-ray pulsars have opened a new window to understanding the generation mechanisms of high-energy emission from these systems, The high statistics allow for careful modeling of the light curve features as well as for phase resolved spectral modeling. We modeled the LAT light curves of the Vela and CTA I pulsars with simulated high-energy light curves generated from geometrical representations of the outer gap and slot gap emission models. within the vacuum retarded dipole and force-free fields. A Markov Chain Monte Carlo maximum likelihood method was used to explore the phase space of the magnetic inclination angle, viewing angle. maximum emission radius, and gap width. We also used the measured spectral cutoff energies to estimate the accelerating parallel electric field dependence on radius. under the assumptions that the high-energy emission is dominated by curvature radiation and the geometry (radius of emission and minimum radius of curvature of the magnetic field lines) is determined by the best fitting light curves for each model. We find that light curves from the vacuum field more closely match the observed light curves and multiwavelength constraints, and that the calculated parallel electric field can place additional constraints on the emission geometry

A giant radio flare from Cygnus X-3 with associated γ-ray emission: The 2011 radio and γ-ray flare of Cyg X-3

International Nuclear Information System (INIS)

Corbel, S.; Dubus, G.; Tomsick, J. A.; Szostek, A.

2012-01-01

With frequent flaring activity of its relativistic jets, Cygnus X-3 (Cyg X-3) is one of the most active microquasars and is the only Galactic black hole candidate with confirmed high-energy γ-ray emission, thanks to detections by Fermi Large Area Telescope (Fermi/LAT) and AGILE. In 2011, we observed Cyg X-3 in order to transit to a soft X-ray state, which is known to be associated with high-energy γ-ray emission. We present the results of a multiwavelength campaign covering a quenched state, when radio emission from Cyg X-3 is at its weakest and the X-ray spectrum is very soft. A giant (~20 Jy) optically thin radio flare marks the end of the quenched state, accompanied by rising non-thermal hard X-rays. Fermi/LAT observations (E≥ 100 MeV) reveal renewed γ-ray activity associated with this giant radio flare, suggesting a common origin for all non-thermal components. In addition, current observations unambiguously show that the γ-ray emission is not exclusively related to the rare giant radio flares. A three-week period of γ-ray emission is also detected when Cyg X-3 was weakly flaring in radio, right before transition to the radio quenched state. There were no γ-rays observed during the ~1-month long quenched state, when the radio flux is weakest. These results suggest transitions into and out of the ultrasoft X-ray (radio-quenched) state trigger γ-ray emission, implying a connection to the accretion process, and also that the γ-ray activity is related to the level of radio flux (and possibly shock formation), strengthening the connection to the relativistic jets.

Fermi-LAT Observation of Supernova Remnant S147

Energy Technology Data Exchange (ETDEWEB)

Katsuta, J.; Uchiyama, Y.; Tanaka, T.; /SLAC /KIPAC, Menlo Park; Tajima, H.; /SLAC /KIPAC, Menlo Park /Nagoya U., Solar-Terrestrial Environ. Lab.; Bechtol, K.; Funk, S.; Lande, J.; /SLAC /KIPAC, Menlo Park; Ballet, J.; /AIM, Saclay; Hanabata, Y.; /Hiroshima U.; Lemoine-Goumard, M.; /CENBG, Gradignan; Takahashi, T.; /JAXA, Sagamihara

2012-08-17

We present an analysis of gamma-ray data obtained with the Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope in the region around SNR S147 (G180.0-1.7). A spatially extended gamma-ray source detected in an energy range of 0.2-10 GeV is found to coincide with SNR S147. We confirm its spatial extension at >5{sigma} confidence level. The gamma-ray flux is (3.8 {+-} 0.6) x 10{sup -8} photons cm{sup -2} s{sup -1}, corresponding to a luminosity of 1.3 x 10{sup 34} (d/1.3 kpc){sup 2} erg s{sup -1} in this energy range. The gamma-ray emission exhibits a possible spatial correlation with prominent H{alpha} filaments of S147. There is no indication that the gamma-ray emission comes from the associated pulsar PSR J0538+2817. The gamma-ray spectrum integrated over the remnant is likely dominated by the decay of neutral {pi} mesons produced through the proton-proton collisions in the filaments. Reacceleration of pre-existing CRs and subsequent adiabatic compression in the filaments is sufficient to provide the required energy density of high-energy protons.

Fermi/LAT observations of dwarf galaxies highly constrain a dark matter interpretation of excess positrons seen in AMS-02, HEAT, and PAMELA

Energy Technology Data Exchange (ETDEWEB)

López, Alejandro [Michigan Center for Theoretical Physics, University of Michigan – Ann Arbor, 450 Church St., Ann Arbor (United States); Savage, Christopher [Nordita (Nordic Institute for Theoretical Physics), KTH Royal Institute of Technology and Stockholm University, Roslagstullsbacken 23, Stockholm (Sweden); Spolyar, Douglas; Adams, Douglas Q., E-mail: aolopez@umich.edu, E-mail: chris@savage.name, E-mail: dspolyar@gmail.com, E-mail: doug.q.adams@gmail.com [Oskar Klein Centre for Cosmoparticle Physics, Stockholm University, Roslagstullsbacken 23, Roslagstullsbacken 21, Stockholm (Sweden)

2016-03-01

It is shown that a Weakly Interacting Massive dark matter Particle (WIMP) interpretation for the positron excess observed in a variety of experiments, HEAT, PAMELA, and AMS-02, is highly constrained by the Fermi/LAT observations of dwarf galaxies. In particular, this paper examines the annihilation channels that best fit the current AMS-02 data (Boudaud et al., 2014), specifically focusing on channels and parameter space not previously explored by the Fermi/LAT collaboration. The Fermi satellite has surveyed the γ-ray sky, and its observations of dwarf satellites are used to place strong bounds on the annihilation of WIMPs into a variety of channels. For the single channel case, we find that dark matter annihilation into (b b-bar ,e{sup +}e{sup -}, μ{sup +}μ{sup -}, τ{sup +}τ{sup -},4-e or 4-τ ) is ruled out as an explanation of the AMS positron excess (here b quarks are a proxy for all quarks, gauge and Higgs bosons). In addition, we find that the Fermi/LAT 2σ upper limits, assuming the best-fit AMS-02 branching ratios, exclude multichannel combinations into b b-bar and leptons. The tension between the results might relax if the branching ratios are allowed to deviate from their best-fit values, though a substantial change would be required. Of all the channels we considered, the only viable channel that survives the Fermi/LAT constraint and produces a good fit to the AMS-02 data is annihilation (via a mediator) to 4-μ, or mainly to 4-μ in the case of multichannel combinations.

SEARCH FOR GAMMA-RAY EMISSION FROM MAGNETARS WITH THE FERMI LARGE AREA TELESCOPE

International Nuclear Information System (INIS)

Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Bouvier, A.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Ballet, J.; Barbiellini, G.; Baring, M. G.; Bastieri, D.; Bonamente, E.; Brigida, M.; Bruel, P.; Burnett, T. H.; Caliandro, G. A.

2010-01-01

We report on the search for 0.1-10 GeV emission from magnetars in 17 months of Fermi Large Area Telescope (LAT) observations. No significant evidence for gamma-ray emission from any of the currently known magnetars is found. The most stringent upper limits to date on their persistent emission in the Fermi energy range are estimated between ∼10 -12 and10 -10 erg s -1 cm -2 , depending on the source. We also searched for gamma-ray pulsations and possible outbursts, also with no significant detection. The upper limits derived support the presence of a cutoff at an energy below a few MeV in the persistent emission of magnetars. They also show the likely need for a revision of current models of outer-gap emission from strongly magnetized pulsars, which, in some realizations, predict detectable GeV emission from magnetars at flux levels exceeding the upper limits identified here using the Fermi-LAT observations.

MODELING THE EARLY MULTIWAVELENGTH EMISSION IN GRB 130427A

International Nuclear Information System (INIS)

Fraija, N.; Lee, W.; Veres, P.

2016-01-01

One of the most powerful gamma-ray bursts, GRB 130427A was swiftly detected from GeV γ-rays to optical wavelengths. In the GeV band, the Large Area Telescope (LAT) on board the Fermi Gamma-Ray Space Telescope observed the highest-energy photon ever recorded of 95 GeV and a bright peak in the early phase followed by emission temporally extended for more than 20 hr. In the optical band, a bright flash with a magnitude of 7.03 ± 0.03 in the time interval from 9.31 to 19.31 s after the trigger was reported by RAPTOR in r band. We study the origin of the GeV γ-ray emission, using the multiwavelength observation detected in X-ray and optical bands. The origin of the temporally extended LAT, X-ray, and optical flux is naturally interpreted as synchrotron radiation, and the 95 GeV photon and the integral flux upper limits placed by the high-altitude water Cerenkov observatory are consistent with synchrotron self-Compton from an adiabatic forward shock propagating into the stellar wind of its progenitor. The extreme LAT peak and the bright optical flash are explained through synchrotron self-Compton and synchrotron emission from the reverse shock, respectively, when the ejecta evolves in the thick-shell regime and carries a significant magnetic field

Radio Detection of the Fermi-LAT Blind Search Millisecond Pulsar J1311-3430

Science.gov (United States)

Ray, P. S.; Ransom, S. M.; Cheung, C. C.; Giroletti, M.; Cognard, I.; Camilo, F.; Bhattacharyya, B.; Roy, J.; Romani, R. W.; Ferrara, E. C.;

FERMI DISCOVERY OF GAMMA-RAY EMISSION FROM NGC 1275

International Nuclear Information System (INIS)

Abdo, A. A.; Ackermann, M.; Ajello, M.; Bechtol, K.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Asano, K.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Brez, A.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Baughman, B. M.; Bonamente, E.; Brigida, M.; Bruel, P.; Burnett, T. H.

2009-01-01

We report the discovery of high-energy (E > 100 MeV) γ-ray emission from NGC 1275, a giant elliptical galaxy lying at the center of the Perseus cluster of galaxies, based on observations made with the Large Area Telescope (LAT) of the Fermi Gamma-ray Space Telescope. The positional center of the γ-ray source is only ∼3' away from the NGC 1275 nucleus, well within the 95% LAT error circle of ∼5'. The spatial distribution of γ-ray photons is consistent with a point source. The average flux and power-law photon index measured with the LAT from 2008 August 4 to 2008 December 5 are F γ = (2.10 ± 0.23) x 10 -7 ph (>100 MeV) cm -2 s -1 and Γ = 2.17 ± 0.05, respectively. The measurements are statistically consistent with constant flux during the four-month LAT observing period. Previous EGRET observations gave an upper limit of F γ -8 ph (>100 MeV) cm -2 s -1 to the γ-ray flux from NGC 1275. This indicates that the source is variable on timescales of years to decades, and therefore restricts the fraction of emission that can be produced in extended regions of the galaxy cluster. Contemporaneous and historical radio observations are also reported. The broadband spectrum of NGC 1275 is modeled with a simple one-zone synchrotron/synchrotron self-Compton model and a model with a decelerating jet flow.

Fermi Discovery of Gamma-Ray Emission from NGC 1275

International Nuclear Information System (INIS)

Abdo, Aous A.; Ackermann, M.; Ajello, M.; Asano, K.; Baldini, L.; Ballet, J.; Barbiellini, Guido; Bastieri, Denis; Baughman, B.M.; Bechtol, K.; Bellazzini, R.; Blandford, R.D.; Bloom, Elliott D.; Bonamente, E.; Borgland, A.W.; Bregeon, J.; Brez, A.; Brigida, M.; Bruel, P.; Burnett, Thompson H.; Caliandro, G.A.

2009-01-01

We report the discovery of high-energy (E > 100 MeV) γ-ray emission from NGC 1275, a giant elliptical galaxy lying at the center of the Perseus cluster of galaxies, based on observations made with the Large Area Telescope (LAT) of the Fermi Gamma-ray Space Telescope. The positional center of the γ-ray source is only ∼3(prime) away from the NGC 1275 nucleus, well within the 95% LAT error circle of ∼5(prime). The spatial distribution of γ-ray photons is consistent with a point source. The average flux and power-law photon index measured with the LAT from 2008 August 4 to 2008 December 5 are F γ = (2.10 ± 0.23) x 10 -7 ph (>100 MeV) cm -2 s -1 and Γ = 2.17 ± 0.05, respectively. The measurements are statistically consistent with constant flux during the four-month LAT observing period. Previous EGRET observations gave an upper limit of F γ -8 ph (>100 MeV) cm -2 s -1 to the γ-ray flux from NGC 1275. This indicates that the source is variable on timescales of years to decades, and therefore restricts the fraction of emission that can be produced in extended regions of the galaxy cluster. Contemporaneous and historical radio observations are also reported. The broadband spectrum of NGC 1275 is modeled with a simple one-zone synchrotron/synchrotron self-Compton model and a model with a decelerating jet flow.

Study of the high energy gamma-ray emission from the crab pulsar with the MAGIC telescope and Fermi-LAT

International Nuclear Information System (INIS)

Saito, Takayuki

2010-01-01

My thesis deals with a fundamental question of high energy gamma-ray astronomy. Namely, I studied the cut-off shape of the Crab pulsar spectrum to distinguish between the leading scenarios for the pulsar models. Pulsars are celestial objects, which emit periodic pulsed electromagnetic radiation (pulsation) from radio to high energy gamma-rays. Two major scenarios evolved in past 40 years to explain the pulsation mechanism: the inner magnetosphere scenario and the outer magnetosphere scenario. Both scenarios predict a high energy cut-off in the gamma-ray energy spectrum, but with different cut-off sharpness. An exponential cut-off is expected for the outer magnetosphere scenario while a super-exponential cut-off is predicted for the inner magnetosphere scenario. Therefore, one of the best ways to confirm or refute these scenarios is to measure the energy spectrum of a pulsar at around the cut-off energy, i.e., at energies between a few GeV and a few tens of GeV. All past attempts to measure pulsar spectra with ground-based instruments have failed while satellite-borne detectors had a too small area to study detailed spectra in the GeV domain. In this thesis, the gamma-ray emission at around the cut-off energy from the Crab pulsar is studied with the MAGIC telescope. The public data of the satellite-borne gamma-ray detector, Fermi-LAT, are also analyzed in order to discuss the MAGIC observation results in comparison with the adjacent energy band. In late 2007, a new trigger system (SUM trigger system) allowed to reduce the threshold energy of the MAGIC telescope from 50 GeV to 25 GeV and the Crab pulsar was successfully detected during observations from October 2007 and January 2009. My analysis reveals that the energy spectrum is consistent with a simple power law between 25 GeV to 100 GeV. The extension of the energy spectrum up to 100 GeV rules out the inner magnetosphere scenario. Fermi-LAT started operation in August 2008. The Fermi-LAT data reveal that a power

Study of the high energy gamma-ray emission from the crab pulsar with the MAGIC telescope and Fermi-LAT

Energy Technology Data Exchange (ETDEWEB)

Saito, Takayuki

2010-12-06

My thesis deals with a fundamental question of high energy gamma-ray astronomy. Namely, I studied the cut-off shape of the Crab pulsar spectrum to distinguish between the leading scenarios for the pulsar models. Pulsars are celestial objects, which emit periodic pulsed electromagnetic radiation (pulsation) from radio to high energy gamma-rays. Two major scenarios evolved in past 40 years to explain the pulsation mechanism: the inner magnetosphere scenario and the outer magnetosphere scenario. Both scenarios predict a high energy cut-off in the gamma-ray energy spectrum, but with different cut-off sharpness. An exponential cut-off is expected for the outer magnetosphere scenario while a super-exponential cut-off is predicted for the inner magnetosphere scenario. Therefore, one of the best ways to confirm or refute these scenarios is to measure the energy spectrum of a pulsar at around the cut-off energy, i.e., at energies between a few GeV and a few tens of GeV. All past attempts to measure pulsar spectra with ground-based instruments have failed while satellite-borne detectors had a too small area to study detailed spectra in the GeV domain. In this thesis, the gamma-ray emission at around the cut-off energy from the Crab pulsar is studied with the MAGIC telescope. The public data of the satellite-borne gamma-ray detector, Fermi-LAT, are also analyzed in order to discuss the MAGIC observation results in comparison with the adjacent energy band. In late 2007, a new trigger system (SUM trigger system) allowed to reduce the threshold energy of the MAGIC telescope from 50 GeV to 25 GeV and the Crab pulsar was successfully detected during observations from October 2007 and January 2009. My analysis reveals that the energy spectrum is consistent with a simple power law between 25 GeV to 100 GeV. The extension of the energy spectrum up to 100 GeV rules out the inner magnetosphere scenario. Fermi-LAT started operation in August 2008. The Fermi-LAT data reveal that a power

Why do intimate partners live apart? Evidence on LAT relationships across Europe

NARCIS (Netherlands)

Liefbroer, A.C.; Poortman, A.R.; Seltzer, J.A.

2015-01-01

BACKGROUND: Most research asks whether or not cohabitation has come to rival marriage. Little is known about the meaning of living apart together (LAT) relationships, and whether LAT is an alternative to marriage and cohabitation or a dating relationship. OBJECTIVE: We examine across Europe: (1) the

CLUES on Fermi-LAT prospects for the extragalactic detection of {mu}{nu}SSM gravitino dark matter

Energy Technology Data Exchange (ETDEWEB)

Gomez-Vargas, G.A., E-mail: germanarturo.gomez@uam.es [Departamento de Fisica Teorica, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Instituto de Fisica Teorica IFT-UAM/CSIC, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Istituto Nazionale di Fisica Nucleare, Sez. Roma Tor Vergata, Roma (Italy)

2012-11-11

The {mu}{nu}SSM is a supersymmetric model that has been proposed to solve the problems generated by other supersymmetric extensions of the standard model of particle physics. Given that R-parity is broken in the {mu}{nu}SSM, the gravitino is a natural candidate for decaying dark matter since its lifetime becomes much longer than the age of the Universe. In this model, gravitino dark matter could be detectable through the emission of a monochromatic gamma ray in a two-body decay. We study the prospects of the Fermi-LAT telescope to detect such monochromatic lines in 5 years of observations of the most massive nearby extragalactic objects. We focus on the Virgo galaxy cluster, since it is associated to a particularly high signal-to-noise ratio and is located at high Galactic latitude. The simulation of both signal and background gamma-ray events is carried out with the Fermi Science Tools, and the dark matter distribution around Virgo is taken from an N-body simulation, with constrained initial conditions provided by the CLUES project. We find that a gravitino with a mass range of 0.6-2 GeV, and with a lifetime range of about 3 Multiplication-Sign 10{sup 27}-2 Multiplication-Sign 10{sup 28}s would be detectable by the Fermi-LAT with a signal-to-noise ratio larger than 3. We also obtain that gravitino masses larger than about 4 GeV are already excluded in the {mu}{nu}SSM by Fermi-LAT data of the galactic halo. These proceedings are based on Ref. [1].

Probing dark matter decay and annihilation with Fermi LAT observations of nearby galaxy clusters

Energy Technology Data Exchange (ETDEWEB)

Huang, Xiaoyuan [Chinese Academy of Sciences, Beijing (China). National Astronomical Observatories; Max-Planck-Institut fuer Physik, Muenchen (Germany); Vertongen, Gilles [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Institut d' Astrophysique de Paris, 75 - Paris (France); Weniger, Christoph [Max-Planck-Institut fuer Physik, Muenchen (Germany)

2011-09-15

Galaxy clusters are promising targets for indirect dark matter searches. Gamma-ray signatures from the decay or annihilation of dark matter particles inside these clusters could be observable with the Fermi Large Area Telescope (LAT). Based on three years of Fermi LAT gamma-ray data, we analyze the flux coming from eight nearby clusters individually as well as in a combined likelihood analysis. Concentrating mostly on signals from dark matter decay, we take into account uncertainties of the cluster masses as determined by X-ray observations and model the cluster emission with extended sources. We do not find significant emission from any of the considered clusters and present limits on the dark matter lifetime and annihilation cross-section. We compare our lifetime limits derived from cluster observations with the limits that can be obtained from the extragalactic gamma-ray background, and find that in case of hadronic decay the cluster limits become competitive at dark matter masses below a few hundred GeV. Finally, we show that in presence of dark matter substructures down to 10{sup -6} solar masses the limits on the dark matter annihilation cross-section could improve by a factor of a few hundred, possibly going down to the thermal cross-section of 3 x 10{sup -26} cm{sup 3}s{sup -1} for dark matter masses

Probing dark matter decay and annihilation with Fermi LAT observations of nearby galaxy clusters

International Nuclear Information System (INIS)

Huang, Xiaoyuan; Vertongen, Gilles; Weniger, Christoph

2011-09-01

Galaxy clusters are promising targets for indirect dark matter searches. Gamma-ray signatures from the decay or annihilation of dark matter particles inside these clusters could be observable with the Fermi Large Area Telescope (LAT). Based on three years of Fermi LAT gamma-ray data, we analyze the flux coming from eight nearby clusters individually as well as in a combined likelihood analysis. Concentrating mostly on signals from dark matter decay, we take into account uncertainties of the cluster masses as determined by X-ray observations and model the cluster emission with extended sources. We do not find significant emission from any of the considered clusters and present limits on the dark matter lifetime and annihilation cross-section. We compare our lifetime limits derived from cluster observations with the limits that can be obtained from the extragalactic gamma-ray background, and find that in case of hadronic decay the cluster limits become competitive at dark matter masses below a few hundred GeV. Finally, we show that in presence of dark matter substructures down to 10 -6 solar masses the limits on the dark matter annihilation cross-section could improve by a factor of a few hundred, possibly going down to the thermal cross-section of 3 x 10 -26 cm 3 s -1 for dark matter masses < or similar 150 GeV and annihilation into b anti b. As a direct application of our results, we derive limits on the lifetime of gravitino dark matter in scenarios with R-parity violation. Implications of these limits for the possible observation of long-lived superparticles at the LHC are discussed. (orig.)

Extremely Bright GRB 160625B with Multiple Emission Episodes: Evidence for Long-term Ejecta Evolution

Energy Technology Data Exchange (ETDEWEB)

Lü, Hou-Jun; Lü, Jing; Zhong, Shu-Qing; Huang, Xiao-Li; Zhang, Hai-Ming; Lan, Lin; Lu, Rui-Jing; Liang, En-Wei [Guangxi Key Laboratory for Relativistic Astrophysics, Department of Physics, Guangxi University, Nanning 530004 (China); Xie, Wei, E-mail: lhj@gxu.edu.edu, E-mail: lew@gxu.edu.cn [School of Physics, Huazhong University of Science and Technology, Wuhan 430074 (China)

2017-11-01

GRB 160625B is an extremely bright GRB with three distinct emission episodes. By analyzing its data observed with the Gamma-Ray Burst Monitor (GBM) and Large Area Telescope (LAT) on board the Fermi mission, we find that a multicolor blackbody (mBB) model can be used to fit very well the spectra of the initial short episode (Episode I) within the hypothesis of photosphere emission of a fireball model. The time-resolved spectra of its main episode (Episode II), which was detected with both GBM and LAT after a long quiescent stage (∼180 s) following the initial episode, can be fitted with a model comprising an mBB component plus a cutoff power-law (CPL) component. This GRB was detected again in the GBM and LAT bands with a long extended emission (Episode III) after a quiescent period of ∼300 s. The spectrum of Episode III is adequately fitted with CPL plus single power-law models, and no mBB component is required. These features may imply that the emission of the three episodes are dominated by distinct physics processes, i.e., Episode I is possible from the cocoon emission surrounding the relativistic jet, Episode II may be from photosphere emission and internal shock of the relativistic jet, and Episode III is contributed by internal and external shocks of the relativistic jet. On the other hand, both X-ray and optical afterglows are consistent with the standard external shocks model.

Search for Spatially Extended Fermi-LAT Sources Using Two Years of Data

Energy Technology Data Exchange (ETDEWEB)

Lande, Joshua; Ackermann, Markus; Allafort, Alice; Ballet, Jean; Bechtol, Keith; Burnett, Toby; Cohen-Tanugi, Johann; Drlica-Wagner, Alex; Funk, Stefan; Giordano, Francesco; Grondin, Marie-Helene; Kerr, Matthew; Lemoine-Goumard, Marianne

2012-07-13

Spatial extension is an important characteristic for correctly associating {gamma}-ray-emitting sources with their counterparts at other wavelengths and for obtaining an unbiased model of their spectra. We present a new method for quantifying the spatial extension of sources detected by the Large Area Telescope (LAT), the primary science instrument on the Fermi Gamma-ray Space Telescope (Fermi). We perform a series of Monte Carlo simulations to validate this tool and calculate the LAT threshold for detecting the spatial extension of sources. We then test all sources in the second Fermi -LAT catalog (2FGL) for extension. We report the detection of seven new spatially extended sources.

Characterisation of L-Type Amino Acid Transporter 1 (LAT1 Expression in Human Skeletal Muscle by Immunofluorescent Microscopy

Directory of Open Access Journals (Sweden)

Nathan Hodson

2017-12-01

Full Text Available The branch chain amino acid leucine is a potent stimulator of protein synthesis in skeletal muscle. Leucine rapidly enters the cell via the L-Type Amino Acid Transporter 1 (LAT1; however, little is known regarding the localisation and distribution of this transporter in human skeletal muscle. Therefore, we applied immunofluorescence staining approaches to visualise LAT1 in wild type (WT and LAT1 muscle-specific knockout (mKO mice, in addition to basal human skeletal muscle samples. LAT1 positive staining was visually greater in WT muscles compared to mKO muscle. In human skeletal muscle, positive LAT1 staining was noted close to the sarcolemmal membrane (dystrophin positive staining, with a greater staining intensity for LAT1 observed in the sarcoplasmic regions of type II fibres (those not stained positively for myosin heavy-chain 1, Type II—25.07 ± 5.93, Type I—13.71 ± 1.98, p < 0.01, suggesting a greater abundance of this protein in these fibres. Finally, we observed association with LAT1 and endothelial nitric oxide synthase (eNOS, suggesting LAT1 association close to the microvasculature. This is the first study to visualise the distribution and localisation of LAT1 in human skeletal muscle. As such, this approach provides a validated experimental platform to study the role and regulation of LAT1 in human skeletal muscle in response to various physiological and pathophysiological models.

THE GAMMA-RAY AND NEUTRINO SKY: A CONSISTENT PICTURE OF FERMI-LAT, MILAGRO, AND ICECUBE RESULTS

International Nuclear Information System (INIS)

Gaggero, Daniele; Urbano, Alfredo; Valli, Mauro; Grasso, Dario; Marinelli, Antonio

2015-01-01

We compute the γ-ray and neutrino diffuse emission of the Galaxy on the basis of a recently proposed phenomenological model characterized by radially dependent cosmic-ray (CR) transport properties. We show how this model, designed to reproduce both Fermi-LAT γ-ray data and local CR observables, naturally reproduces the anomalous TeV diffuse emission observed by Milagro in the inner Galactic plane. Above 100 TeV our picture predicts a neutrino flux that is about five (two) times larger than the neutrino flux computed with conventional models in the Galactic Center region (full-sky). Explaining in that way up to ∼25% of the flux measured by IceCube, we reproduce the full-sky IceCube spectrum adding an extra-Galactic component derived from the muonic neutrinos flux in the northern hemisphere. We also present precise predictions for the Galactic plane region where the flux is dominated by the Galactic emission

Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation.

Science.gov (United States)

Núñez, Bárbara; Martínez de Mena, Raquel; Obregon, Maria Jesus; Font-Llitjós, Mariona; Nunes, Virginia; Palacín, Manuel; Dumitrescu, Alexandra M; Morte, Beatriz; Bernal, Juan

2014-01-01

Thyroid hormone entry into cells is facilitated by transmembrane transporters. Mutations of the specific thyroid hormone transporter, MCT8 (Monocarboxylate Transporter 8, SLC16A2) cause an X-linked syndrome of profound neurological impairment and altered thyroid function known as the Allan-Herndon-Dudley syndrome. MCT8 deficiency presumably results in failure of thyroid hormone to reach the neural target cells in adequate amounts to sustain normal brain development. However during the perinatal period the absence of Mct8 in mice induces a state of cerebral cortex hyperthyroidism, indicating increased brain access and/or retention of thyroid hormone. The contribution of other transporters to thyroid hormone metabolism and action, especially in the context of MCT8 deficiency is not clear. We have analyzed the role of the heterodimeric aminoacid transporter Lat2 (Slc7a8), in the presence or absence of Mct8, on thyroid hormone concentrations and on expression of thyroid hormone-dependent cerebral cortex genes. To this end we generated Lat2-/-, and Mct8-/yLat2-/- mice, to compare with wild type and Mct8-/y mice during postnatal development. As described previously the single Mct8 KO neonates had a transient increase of 3,5,3'-triiodothyronine concentration and expression of thyroid hormone target genes in the cerebral cortex. Strikingly the absence of Lat2 in the double Mct8Lat2 KO prevented the effect of Mct8 inactivation in newborns. The Lat2 effect was not observed from postnatal day 5 onwards. On postnatal day 21 the Mct8 KO displayed the typical pattern of thyroid hormone concentrations in plasma, decreased cortex 3,5,3'-triiodothyronine concentration and Hr expression, and concomitant Lat2 inactivation produced little to no modifications. As Lat2 is expressed in neurons and in the choroid plexus, the results support a role for Lat2 in the supply of thyroid hormone to the cerebral cortex during early postnatal development.

Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation.

Directory of Open Access Journals (Sweden)

Bárbara Núñez

Full Text Available Thyroid hormone entry into cells is facilitated by transmembrane transporters. Mutations of the specific thyroid hormone transporter, MCT8 (Monocarboxylate Transporter 8, SLC16A2 cause an X-linked syndrome of profound neurological impairment and altered thyroid function known as the Allan-Herndon-Dudley syndrome. MCT8 deficiency presumably results in failure of thyroid hormone to reach the neural target cells in adequate amounts to sustain normal brain development. However during the perinatal period the absence of Mct8 in mice induces a state of cerebral cortex hyperthyroidism, indicating increased brain access and/or retention of thyroid hormone. The contribution of other transporters to thyroid hormone metabolism and action, especially in the context of MCT8 deficiency is not clear. We have analyzed the role of the heterodimeric aminoacid transporter Lat2 (Slc7a8, in the presence or absence of Mct8, on thyroid hormone concentrations and on expression of thyroid hormone-dependent cerebral cortex genes. To this end we generated Lat2-/-, and Mct8-/yLat2-/- mice, to compare with wild type and Mct8-/y mice during postnatal development. As described previously the single Mct8 KO neonates had a transient increase of 3,5,3'-triiodothyronine concentration and expression of thyroid hormone target genes in the cerebral cortex. Strikingly the absence of Lat2 in the double Mct8Lat2 KO prevented the effect of Mct8 inactivation in newborns. The Lat2 effect was not observed from postnatal day 5 onwards. On postnatal day 21 the Mct8 KO displayed the typical pattern of thyroid hormone concentrations in plasma, decreased cortex 3,5,3'-triiodothyronine concentration and Hr expression, and concomitant Lat2 inactivation produced little to no modifications. As Lat2 is expressed in neurons and in the choroid plexus, the results support a role for Lat2 in the supply of thyroid hormone to the cerebral cortex during early postnatal development.

Fermi Discovery of Gamma-Ray Emission from NGC 1275

Energy Technology Data Exchange (ETDEWEB)

Abdo, Aous A.; /Naval Research Lab, Wash., D.C.; Ackermann, M.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Ajello, M.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Asano, K.; /Tokyo Inst. Tech.; Baldini, L.; /INFN, Pisa; Ballet, J.; /DAPNIA, Saclay; Barbiellini, Guido; /INFN, Trieste /Trieste U.; Bastieri, Denis; /INFN, Padua /Padua U.; Baughman, B.M.; /Ohio State U.; Bechtol, K.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bellazzini, R.; /INFN, Pisa; Blandford, R.D.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bloom, Elliott D.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bonamente, E.; /INFN, Perugia /Perugia U.; Borgland, A.W.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bregeon, J.; /INFN, Pisa; Brez, A.; /INFN, Pisa; Brigida, M.; /Bari U. /INFN, Bari; Bruel, P.; /Ecole Polytechnique; Burnett, Thompson H.; /Washington U., Seattle; Caliandro, G.A.; /Bari U. /INFN, Bari /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /IASF, Milan /IASF, Milan /DAPNIA, Saclay /ASDC, Frascati /INFN, Perugia /Perugia U. /SISSA, Trieste /George Mason U. /Naval Research Lab, Wash., D.C. /NASA, Goddard /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /INFN, Perugia /Perugia U. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Montpellier U. /ASDC, Frascati /Sonoma State U. /Stockholm U., OKC /Royal Inst. Tech., Stockholm /Stockholm U. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Naval Research Lab, Wash., D.C. /INFN, Trieste /Bari U. /INFN, Bari /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /NASA, Goddard /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /CENBG, Gradignan /CENBG, Gradignan /Montpellier U. /Bari U. /INFN, Bari /Naval Research Lab, Wash., D.C. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /INFN, Trieste /Hiroshima U.; /more authors..

2009-05-15

We report the discovery of high-energy (E > 100 MeV) {gamma}-ray emission from NGC 1275, a giant elliptical galaxy lying at the center of the Perseus cluster of galaxies, based on observations made with the Large Area Telescope (LAT) of the Fermi Gamma-ray Space Telescope. The positional center of the {gamma}-ray source is only {approx}3{prime} away from the NGC 1275 nucleus, well within the 95% LAT error circle of {approx}5{prime}. The spatial distribution of {gamma}-ray photons is consistent with a point source. The average flux and power-law photon index measured with the LAT from 2008 August 4 to 2008 December 5 are F{sub {gamma}} = (2.10 {+-} 0.23) x 10{sup -7} ph (>100 MeV) cm{sup -2} s{sup -1} and {Gamma} = 2.17 {+-} 0.05, respectively. The measurements are statistically consistent with constant flux during the four-month LAT observing period. Previous EGRET observations gave an upper limit of F{sub {gamma}} < 3.72 x 10{sup -8} ph (>100 MeV) cm{sup -2} s{sup -1} to the {gamma}-ray flux from NGC 1275. This indicates that the source is variable on timescales of years to decades, and therefore restricts the fraction of emission that can be produced in extended regions of the galaxy cluster. Contemporaneous and historical radio observations are also reported. The broadband spectrum of NGC 1275 is modeled with a simple one-zone synchrotron/synchrotron self-Compton model and a model with a decelerating jet flow.

DIRAC framework evaluation for the Fermi-LAT and CTA experiments

International Nuclear Information System (INIS)

Arrabito, L; Cohen-Tanugi, J; Piron, F; Renaud, M; Rolland, V; Diaz, R Graciani; Longo, F; Kuss, M; Sapunov, M; Tsaregorodtsev, A; Zimmer, S

2014-01-01

DIRAC (Distributed Infrastructure with Remote Agent Control) is a general framework for the management of tasks over distributed heterogeneous computing environments. It has been originally developed to support the production activities of the LHCb (Large Hadron Collider Beauty) experiment and today is extensively used by several particle physics and biology communities. Current (Fermi Large Area Telescope – LAT) and planned (Cherenkov Telescope Array – CTA) new generation astrophysical/cosmological experiments, with very large processing and storage needs, are currently investigating the usability of DIRAC in this context. Each of these use cases has some peculiarities: Fermi-LAT will interface DIRAC to its own workflow system to allow the access to the grid resources, while CTA is using DIRAC as workflow management system for Monte Carlo production and analysis on the grid. We describe the prototype effort that we lead toward deploying a DIRAC solution for some aspects of Fermi-LAT and CTA needs.

LAT Onboard Science: Gamma-Ray Burst Identification

International Nuclear Information System (INIS)

Kuehn, Frederick; Hughes, Richard; Smith, Patrick; Winer, Brian; Bonnell, Jerry; Norris, Jay; Ritz, Steven; Russell, James

2007-01-01

The main goal of the Large Area Telescope (LAT) onboard science program is to provide quick identification and localization of Gamma Ray Bursts (GRB) onboard the LAT for follow-up observations by other observatories. The GRB identification and localization algorithm will provide celestial coordinates with an error region that will be distributed via the Gamma ray burst Coordinate Network (GCN). We present results that show our sensitivity to bursts as characterized using Monte Carlo simulations of the GLAST observatory. We describe and characterize the method of onboard track determination and the GRB identification and localization algorithm. Onboard track determination is considerably different than in the on-ground case, resulting in a substantially altered point spread function. The algorithm contains tunable parameters which may be adjusted after launch when real bursts characteristics at very high energies have been identified

MicroRNA-181b promotes ovarian cancer cell growth and invasion by targeting LATS2

Energy Technology Data Exchange (ETDEWEB)

Xia, Ying; Gao, Yan, E-mail: gaoyanhdhos@126.com

2014-05-09

Highlights: • miR-181b is upregulated in human ovarian cancer tissues. • miR-181b promotes ovarian cancer cell proliferation and invasion. • LATS2 is a direct target of miR-181b. • LATS2 is involved in miR-181b-induced ovarian cancer cell growth and invasion. - Abstract: MicroRNAs (miRNAs) are strongly implicated in tumorigenesis and metastasis. In this study, we showed significant upregulation of miR-181b in ovarian cancer tissues, compared with the normal ovarian counterparts. Forced expression of miR-181b led to remarkably enhanced proliferation and invasion of ovarian cancer cells while its knockdown induced significant suppression of these cellular events. The tumor suppressor gene, LATS2 (large tumor suppressor 2), was further identified as a novel direct target of miR-181b. Specifically, miR-181b bound directly to the 3′-untranslated region (UTR) of LATS2 and suppressed its expression. Restoration of LATS2 expression partially reversed the oncogenic effects of miR-181b. Our results indicate that miR-181b promotes proliferation and invasion by targeting LATS2 in ovarian cancer cells. These findings support the utility of miR-181b as a potential diagnostic and therapeutic target for ovarian cancer.

Observation of very low frequency emissions at Indian Antarctic ...

Indian Academy of Sciences (India)

Recently, we have succeeded in recording VLF emissions at the Indian Antarctic station, Maitri (geom. lat. 62° S, geom. long. 57.23°E, =4.5) using a T-type antenna, pre/main amplifiers and digital audio tape recorder. VLF hiss in the frequency ranges 11–13 kHz and 13–14.5 kHz and some riser-type emissions in the ...

Environmental Tests of the Flight GLAST LAT Tracker Towers

Energy Technology Data Exchange (ETDEWEB)

Bagagli, R.; Baldini, L.; Bellazzini, R.; Barbiellini, G.; Belli, F.; Borden, T.; Brez, A.; Brigida, M.; Caliandro, G.A.; Cecchi, C.; Cohen-Tanugi, J.; Angelis, A.De; Drell, P.; Favuzzi, C.; Fusco, P.; Gargano, F.; Germani, S.; Giglietto, N.; Giordano, F.; Goodman, J.; Himel, T.

2008-03-12

The Gamma-ray Large Area Space telescope (GLAST) is a gamma-ray satellite scheduled for launch in 2008. Before the assembly of the Tracker subsystem of the Large Area Telescope (LAT) science instrument of GLAST, every component (tray) and module (tower) has been subjected to extensive ground testing required to ensure successful launch and on-orbit operation. This paper describes the sequence and results of the environmental tests performed on an engineering model and all the flight hardware of the GLAST LAT Tracker. Environmental tests include vibration testing, thermal cycles and thermal-vacuum cycles of every tray and tower as well as the verification of their electrical performance.

Spectrum of the isotropic diffuse gamma-ray emission derived from first-year Fermi Large Area Telescope data.

Science.gov (United States)

Abdo, A A; Ackermann, M; Ajello, M; Atwood, W B; Baldini, L; Ballet, J; Barbiellini, G; Bastieri, D; Baughman, B M; Bechtol, K; Bellazzini, R; Berenji, B; Blandford, R D; Bloom, E D; Bonamente, E; Borgland, A W; Bregeon, J; Brez, A; Brigida, M; Bruel, P; Burnett, T H; Buson, S; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Cavazzuti, E; Cecchi, C; Celik, O; Charles, E; Chekhtman, A; Cheung, C C; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; Cominsky, L R; Conrad, J; Cutini, S; Dermer, C D; de Angelis, A; de Palma, F; Digel, S W; Di Bernardo, G; do Couto e Silva, E; Drell, P S; Drlica-Wagner, A; Dubois, R; Dumora, D; Farnier, C; Favuzzi, C; Fegan, S J; Focke, W B; Fortin, P; Frailis, M; Fukazawa, Y; Funk, S; Fusco, P; Gaggero, D; Gargano, F; Gasparrini, D; Gehrels, N; Germani, S; Giebels, B; Giglietto, N; Giommi, P; Giordano, F; Glanzman, T; Godfrey, G; Grenier, I A; Grondin, M-H; Grove, J E; Guillemot, L; Guiriec, S; Gustafsson, M; Hanabata, Y; Harding, A K; Hayashida, M; Hughes, R E; Itoh, R; Jackson, M S; Jóhannesson, G; Johnson, A S; Johnson, R P; Johnson, T J; Johnson, W N; Kamae, T; Katagiri, H; Kataoka, J; Kawai, N; Kerr, M; Knödlseder, J; Kocian, M L; Kuehn, F; Kuss, M; Lande, J; Latronico, L; Lemoine-Goumard, M; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Makeev, A; Mazziotta, M N; McConville, W; McEnery, J E; Meurer, C; Michelson, P F; Mitthumsiri, W; Mizuno, T; Moiseev, A A; Monte, C; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Nolan, P L; Norris, J P; Nuss, E; Ohsugi, T; Omodei, N; Orlando, E; Ormes, J F; Paneque, D; Panetta, J H; Parent, D; Pelassa, V; Pepe, M; Pesce-Rollins, M; Piron, F; Porter, T A; Rainò, S; Rando, R; Razzano, M; Reimer, A; Reimer, O; Reposeur, T; Ritz, S; Rochester, L S; Rodriguez, A Y; Roth, M; Ryde, F; Sadrozinski, H F-W; Sanchez, D; Sander, A; Saz Parkinson, P M; Scargle, J D; Sellerholm, A; Sgrò, C; Shaw, M S; Siskind, E J; Smith, D A; Smith, P D; Spandre, G; Spinelli, P; Starck, J-L; Strickman, M S; Strong, A W; Suson, D J; Tajima, H; Takahashi, H; Takahashi, T; Tanaka, T; Thayer, J B; Thayer, J G; Thompson, D J; Tibaldo, L; Torres, D F; Tosti, G; Tramacere, A; Uchiyama, Y; Usher, T L; Vasileiou, V; Vilchez, N; Vitale, V; Waite, A P; Wang, P; Winer, B L; Wood, K S; Ylinen, T; Ziegler, M

2010-03-12

We report on the first Fermi Large Area Telescope (LAT) measurements of the so-called "extragalactic" diffuse gamma-ray emission (EGB). This component of the diffuse gamma-ray emission is generally considered to have an isotropic or nearly isotropic distribution on the sky with diverse contributions discussed in the literature. The derivation of the EGB is based on detailed modeling of the bright foreground diffuse Galactic gamma-ray emission, the detected LAT sources, and the solar gamma-ray emission. We find the spectrum of the EGB is consistent with a power law with a differential spectral index gamma = 2.41 +/- 0.05 and intensity I(>100 MeV) = (1.03 +/- 0.17) x 10(-5) cm(-2) s(-1) sr(-1), where the error is systematics dominated. Our EGB spectrum is featureless, less intense, and softer than that derived from EGRET data.

Modulated High-Energy Gamma-Ray Emission from the Micro-quasar Cygnus X-3

International Nuclear Information System (INIS)

Abdo, A.A.; Cheung, C.C.; Dermer, C.D.; Grove, J.E.; Johnson, W.N.; Lovellette, M.N.; Makeev, A.; Ray, P.S.; Strickman, M.S.; Wood, K.S.; Abdo, A.A.; Cheung, C.C.; Ackermann, M.; Ajello, M.; Bechtol, K.; Berenji, B.; Blandford, R.D.; Bloom, E.D.; Borgland, A.W.; Cameron, R.A.; Chiang, J.; Claus, R.; Digel, S.W.; Silva, E.D.E.; Drell, P.S.; Dubois, R.; Focke, W.B.; Glanzman, T.; Godfrey, G.; Hayashida, M.; Johannesson, G.; Johnson, A.S.; Kamae, T.; Kocian, M.L.; Lande, J.; Madejski, G.M.; Michelson, P.F.; Mitthumsiri, W.; Monzani, M.E.; Moskalenko, I.V.; Murgia, S.; Nolan, P.L.; Paneque, D.; Reimer, A.; Reimer, O.; Rochester, L.S.; Romani, R.W.; Tanaka, T.; Thayer, J.B.; Tramacere, A.; Uchiyama, Y.; Usher, T.L.; Waite, A.P.; Wang, P.; Ackermann, M.; Ajello, M.; Bechtol, K.; Berenji, B.; Blandford, R.D.; Bloom, E.D.; Borgland, A.W.; Cameron, R.A.; Chiang, J.; Claus, R.; Digel, S.W.; Silva, E.D.E.; Drell, P.S.; Dubois, R.; Focke, W.B.; Glanzman, T.; Godfrey, G.; Hayashida, M.; Johannesson, G.; Johnson, A.S.; Kamae, T.; Kocian, M.L.; Lande, J.; Madejski, G.M.; Michelson, P.F.; Mitthumsiri, W.; Monzani, M.E.; Moskalenko, I.V.; Murgia, S.; Nolan, P.L.; Paneque, D.; Reimer, A.; Reimer, O.; Rochester, L.S.; Romani, R.W.; Tanaka, T.; Thayer, J.B.; Tramacere, A.; Uchiyama, Y.; Usher, T.L.; Waite, A.P.; Wang, P.; Axelsson, M.; Hjalmarsdotter, L.; Axelsson, M.; Conrad, J.; Hjalmarsdotter, L.; Jackson, M.S.; Meurer, C.; Ryde, F.; Ylinen, T.; Baldini, L.; Bellazzini, R.; Brez, A.; Kuss, M.; Latronico, L.; Omodei, N.; Pesce-Rollins, M.; Razzano, M.; Sgro, C.; Ballet, J.; Casandjian, J.M.; Chaty, S.; Corbel, S.; Grenier, I.A.; Koerding, E.; Rodriguez, J.; Starck, J.L.; Tibaldo, L.

2009-01-01

Micro-quasars are accreting black holes or neutron stars in binary systems with associated relativistic jets. Despite their frequent outburst activity, they have never been unambiguously detected emitting high-energy gamma rays. The Fermi Large Area Telescope (LAT) has detected a variable high-energy source coinciding with the position of the x-ray binary and micro-quasar Cygnus X-3. Its identification with Cygnus X-3 is secured by the detection of its orbital period in gamma rays, as well as the correlation of the LAT flux with radio emission from the relativistic jets of Cygnus X-3. The gamma-ray emission probably originates from within the binary system, opening new areas in which to study the formation of relativistic jets. (authors)

Engineering light emission of two-dimensional materials in both the weak and strong coupling regimes

Science.gov (United States)

Brotons-Gisbert, Mauro; Martínez-Pastor, Juan P.; Ballesteros, Guillem C.; Gerardot, Brian D.; Sánchez-Royo, Juan F.

2018-01-01

Two-dimensional (2D) materials have promising applications in optoelectronics, photonics, and quantum technologies. However, their intrinsically low light absorption limits their performance, and potential devices must be accurately engineered for optimal operation. Here, we apply a transfer matrix-based source-term method to optimize light absorption and emission in 2D materials and related devices in weak and strong coupling regimes. The implemented analytical model accurately accounts for experimental results reported for representative 2D materials such as graphene and MoS2. The model has been extended to propose structures to optimize light emission by exciton recombination in MoS2 single layers, light extraction from arbitrarily oriented dipole monolayers, and single-photon emission in 2D materials. Also, it has been successfully applied to retrieve exciton-cavity interaction parameters from MoS2 microcavity experiments. The present model appears as a powerful and versatile tool for the design of new optoelectronic devices based on 2D semiconductors such as quantum light sources and polariton lasers.

Bioprospecting the lat gene in soil samples

Indian Academy of Sciences (India)

Unknown

of the work reported here was to discover the presence of the lat gene in ... and the mixture was incubated at 65°C for an hour. On reaching ... 70% ethanol for 4 h at room temperature. Ethanol (70 .... Prolonged exposure of one week confirmed ...

Imaging the L-type amino acid transporter-1 (LAT1 with Zr-89 immunoPET.

Directory of Open Access Journals (Sweden)

Oluwatayo F Ikotun

Full Text Available The L-type amino acid transporter-1 (LAT1, SLC7A5 is upregulated in a wide range of human cancers, positively correlated with the biological aggressiveness of tumors, and a promising target for both imaging and therapy. Radiolabeled amino acids such as O-(2-[(18F]fluoroethyl-L-tyrosine (FET that are transport substrates for system L amino acid transporters including LAT1 have met limited success for oncologic imaging outside of the brain, and thus new strategies are needed for imaging LAT1 in systemic cancers. Here, we describe the development and biological evaluation of a novel zirconium-89 labeled antibody, [(89Zr]DFO-Ab2, targeting the extracellular domain of LAT1 in a preclinical model of colorectal cancer. This tracer demonstrated specificity for LAT1 in vitro and in vivo with excellent tumor imaging properties in mice with xenograft tumors. PET imaging studies showed high tumor uptake, with optimal tumor-to-non target contrast achieved at 7 days post administration. Biodistribution studies demonstrated tumor uptake of 10.5 ± 1.8 percent injected dose per gram (%ID/g at 7 days with a tumor to muscle ratio of 13 to 1. In contrast, the peak tumor uptake of the radiolabeled amino acid [(18F]FET was 4.4 ± 0.5 %ID/g at 30 min after injection with a tumor to muscle ratio of 1.4 to 1. Blocking studies with unlabeled anti-LAT1 antibody demonstrated a 55% reduction of [(89Zr]DFO-Ab2 accumulation in the tumor at 7 days. These results are the first report of direct PET imaging of LAT1 and demonstrate the potential of immunoPET agents for imaging specific amino acid transporters.

Synthesis of silver hollow nanoparticles and observation of photoluminescence emission properties

International Nuclear Information System (INIS)

Desarkar, H.S.; Kumbhakar, P.; Mitra, A.K.

2013-01-01

Preparation of hollow silver nanoparticles (HSNs) along-with solid silver nanoparticles are reported by Nd:YAG laser ablation of solid silver target immersed in water medium with a laser ablation time (LAT) duration of 50 min and with the incident laser fluence of 151 J/cm 2 . It is found that only solid silver nanoparticles are produced when the experiment is carried out with smaller values of LAT duration. The synthesized samples are characterized by using transmission electron microscopy and UV–Visible absorption spectroscopy. The UV–Visible absorption spectra of the samples show sharp absorptions in the ultraviolet and in visible regions due to interband transition and surface plasmon resonance oscillations in Ag nanoparticles, respectively. It is found that all samples exhibit photoluminescence (PL) emission, at room temperature, in the UV–Visible region peaked at ∼346 nm, due to the recombination of electrons with holes from sp conduction band to d band of Ag. The sample containing HSNs exhibits strong PL emission and the value of peak PL emission intensity is enhanced by the factor of 2.4 in comparison to that obtained from the sample synthesized with LAT duration of 20 min. The synthesized HSNs may find applications in catalysis and in chemical sensing. - Highlights: ►Hollow silver nanoparticles of 15–60 nm particle sizes are prepared by laser ablation. ►Prepared Ag nanoparticles show sharp absorptions in the UV and visible regions. ►Strong interband transition along-with SPR oscillations is reported. ►Enhancement (2.4 times) in photoluminescence emission in the UV region is reported.

Characterizing high-energy light curves of Fermi/Lat GRBs

Energy Technology Data Exchange (ETDEWEB)

Gillette, Jarred [SLAC National Accelerator Lab., Menlo Park, CA (United States)

2015-08-21

A systematic analysis of the light curves of Gamma-Ray Burst (GRBs) with redshift and detected at high-energy (> 100 MeV) by Fermi/LAT has never been done before our work, because there were only a handful of detections. Now we have 20 of those, which we can use to characterize the GRBs in their rest frame. We compared a characteristic decay times Tc of GRBs with redshifts using the new “Pass 8” data, and used a Crystal Ball function to parametrize GRB characteristics. An unexpected anti-correlation between Tc and the peak flux was observed. This means that brighter peaked GRBs have shorter durations. There is also no correlation between the Tc and the decay index, which makes the anti-correlation with brightness more clear. This results appears to be consistent with the External Shock model, which is one of the competing hypothesis on the origin of the high-energy emission. We did not observe any bimodality, which is seen in GRBs at lower energies.

Stochastic modeling of the Fermi/LAT γ-ray blazar variability

Energy Technology Data Exchange (ETDEWEB)

Sobolewska, M. A.; Siemiginowska, A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Kelly, B. C. [Department of Physics, Broida Hall, University of California, Santa Barbara, CA 93107 (United States); Nalewajko, K., E-mail: malgosia@camk.edu.pl [JILA, University of Colorado and National Institute of Standards and Technology, 440 UCB, Boulder, CO 80309 (United States)

2014-05-10

We study the γ-ray variability of 13 blazars observed with the Fermi/Large Area Telescope (LAT). These blazars have the most complete light curves collected during the first four years of the Fermi sky survey. We model them with the Ornstein-Uhlenbeck (OU) process or a mixture of the OU processes. The OU process has power spectral density (PSD) proportional to 1/f {sup α} with α changing at a characteristic timescale, τ{sub 0}, from 0 (τ >> τ{sub 0}) to 2 (τ << τ{sub 0}). The PSD of the mixed OU process has two characteristic timescales and an additional intermediate region with 0 < α < 2. We show that the OU model provides a good description of the Fermi/LAT light curves of three blazars in our sample. For the first time, we constrain a characteristic γ-ray timescale of variability in two BL Lac sources, 3C 66A and PKS 2155-304 (τ{sub 0} ≅ 25 days and τ{sub 0} ≅ 43 days, respectively, in the observer's frame), which are longer than the soft X-ray timescales detected in blazars and Seyfert galaxies. We find that the mixed OU process approximates the light curves of the remaining 10 blazars better than the OU process. We derive limits on their long and short characteristic timescales, and infer that their Fermi/LAT PSD resemble power-law functions. We constrain the PSD slopes for all but one source in the sample. We find hints for sub-hour Fermi/LAT variability in four flat spectrum radio quasars. We discuss the implications of our results for theoretical models of blazar variability.

Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1

Directory of Open Access Journals (Sweden)

Natesh Singh

2018-04-01

Full Text Available The large neutral amino acid transporter 1 (LAT1, or SLC7A5 is a sodium- and pH-independent transporter, which supplies essential amino acids (e.g., leucine, phenylalanine to cells. It plays an important role at the Blood–Brain Barrier (BBB where it facilitates the transport of thyroid hormones, pharmaceuticals (e.g., l-DOPA, gabapentin, and metabolites into the brain. Moreover, its expression is highly upregulated in various types of human cancer that are characterized by an intense demand for amino acids for growth and proliferation. Therefore, LAT1 is believed to be an important drug target for cancer treatment. With the crystallization of the arginine/agmatine antiporter (AdiC from Escherichia Coli, numerous homology models of LAT1 have been built to elucidate the substrate binding site, ligand–transporter interaction, and structure–function relationship. The use of these models in combination with molecular docking and experimental testing has identified novel chemotypes of ligands of LAT1. Here, we highlight the structure, function, transport mechanism, and homology modeling of LAT1. Additionally, results from structure–function studies performed on LAT1 are addressed, which have enhanced our knowledge of the mechanism of substrate binding and translocation. This is followed by a discussion on ligand- and structure-based approaches, with an emphasis on elucidating the molecular basis of LAT1 inhibition. Finally, we provide an exhaustive summary of different LAT1 inhibitors that have been identified so far, including the recently discovered irreversible covalent inhibitors.

NEW FERMI-LAT EVENT RECONSTRUCTION REVEALS MORE HIGH-ENERGY GAMMA RAYS FROM GAMMA-RAY BURSTS

Energy Technology Data Exchange (ETDEWEB)

Atwood, W. B. [Santa Cruz Institute for Particle Physics, Department of Physics and Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Baldini, L. [Universita di Pisa and Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bregeon, J.; Pesce-Rollins, M.; Sgro, C.; Tinivella, M. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bruel, P. [Laboratoire Leprince-Ringuet, Ecole polytechnique, CNRS/IN2P3, Palaiseau (France); Chekhtman, A. [Center for Earth Observing and Space Research, College of Science, George Mason University, Fairfax, VA 22030 (United States); Cohen-Tanugi, J. [Laboratoire Univers et Particules de Montpellier, Universite Montpellier 2, CNRS/IN2P3, F-34095 Montpellier (France); Drlica-Wagner, A.; Omodei, N.; Rochester, L. S.; Usher, T. L. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Granot, J. [Department of Natural Sciences, The Open University of Israel, 1 University Road, P.O. Box 808, Ra' anana 43537 (Israel); Longo, F. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Razzaque, S. [Department of Physics, University of Johannesburg, Auckland Park 2006 (South Africa); Zimmer, S., E-mail: melissa.pesce.rollins@pi.infn.it, E-mail: nicola.omodei@stanford.edu, E-mail: granot@openu.ac.il [Department of Physics, Stockholm University, AlbaNova, SE-106 91 Stockholm (Sweden)

2013-09-01

Based on the experience gained during the four and a half years of the mission, the Fermi-LAT Collaboration has undertaken a comprehensive revision of the event-level analysis going under the name of Pass 8. Although it is not yet finalized, we can test the improvements in the new event reconstruction with the special case of the prompt phase of bright gamma-ray bursts (GRBs), where the signal-to-noise ratio is large enough that loose selection cuts are sufficient to identify gamma rays associated with the source. Using the new event reconstruction, we have re-analyzed 10 GRBs previously detected by the Large Area Telescope (LAT) for which an X-ray/optical follow-up was possible and found four new gamma rays with energies greater than 10 GeV in addition to the seven previously known. Among these four is a 27.4 GeV gamma ray from GRB 080916C, which has a redshift of 4.35, thus making it the gamma ray with the highest intrinsic energy ({approx}147 GeV) detected from a GRB. We present here the salient aspects of the new event reconstruction and discuss the scientific implications of these new high-energy gamma rays, such as constraining extragalactic background light models, Lorentz invariance violation tests, the prompt emission mechanism, and the bulk Lorentz factor of the emitting region.

Constraining decaying dark matter with Fermi LAT gamma-rays

International Nuclear Information System (INIS)

Zhang, Le; Sigl, Günter; Weniger, Christoph; Maccione, Luca; Redondo, Javier

2010-01-01

High energy electrons and positrons from decaying dark matter can produce a significant flux of gamma rays by inverse Compton off low energy photons in the interstellar radiation field. This possibility is inevitably related with the dark matter interpretation of the observed PAMELA and FERMI excesses. The aim of this paper is providing a simple and universal method to constrain dark matter models which produce electrons and positrons in their decay by using the Fermi LAT gamma-ray observations in the energy range between 0.5 GeV and 300 GeV. We provide a set of universal response functions that, once convolved with a specific dark matter model produce the desired constraints. Our response functions contain all the astrophysical inputs such as the electron propagation in the galaxy, the dark matter profile, the gamma-ray fluxes of known origin, and the Fermi LAT data. We study the uncertainties in the determination of the response functions and apply them to place constraints on some specific dark matter decay models that can well fit the positron and electron fluxes observed by PAMELA and Fermi LAT. To this end we also take into account prompt radiation from the dark matter decay. We find that with the available data decaying dark matter cannot be excluded as source of the PAMELA positron excess

Gamma-ray emission from internal shocks in novae

Science.gov (United States)

Martin, P.; Dubus, G.; Jean, P.; Tatischeff, V.; Dosne, C.

2018-04-01

Context. Gamma-ray emission at energies ≥100 MeV has been detected from nine novae using the Fermi Large Area Telescope (LAT), and can be explained by particle acceleration at shocks in these systems. Eight out of these nine objects are classical novae in which interaction of the ejecta with a tenuous circumbinary material is not expected to generate detectable gamma-ray emission. Aim. We examine whether particle acceleration at internal shocks can account for the gamma-ray emission from these novae. The shocks result from the interaction of a fast wind radiatively-driven by nuclear burning on the white dwarf with material ejected in the initial runaway stage of the nova outburst. Methods: We present a one-dimensional model for the dynamics of a forward and reverse shock system in a nova ejecta, and for the associated time-dependent particle acceleration and high-energy gamma-ray emission. Non-thermal proton and electron spectra are calculated by solving a time-dependent transport equation for particle injection, acceleration, losses, and escape from the shock region. The predicted emission is compared to LAT observations of V407 Cyg, V1324 Sco, V959 Mon, V339 Del, V1369 Cen, and V5668 Sgr. Results: The ≥100 MeV gamma-ray emission arises predominantly from particles accelerated up to 100 GeV at the reverse shock and undergoing hadronic interactions in the dense cooling layer downstream of the shock. The emission rises within days after the onset of the wind, quickly reaches a maximum, and its subsequent decrease reflects mostly the time evolution of the wind properties. Comparison to gamma-ray data points to a typical scenario where an ejecta of mass 10-5-10-4 M⊙ expands in a homologous way with a maximum velocity of 1000-2000 km s-1, followed within a day by a wind with a velocity values of which result in the majority of best-fit models having gamma-ray spectra with a high-energy turnover below 10 GeV. Our typical model is able to account for the main

Dark matter properties implied by gamma ray interstellar emission models

Energy Technology Data Exchange (ETDEWEB)

Balázs, Csaba; Li, Tong, E-mail: csaba.balazs@monash.edu, E-mail: tong.li@monash.edu [ARC Centre of Excellence for Particle Physics at the Tera-scale, School of Physics and Astronomy, Monash University, Melbourne, Victoria 3800 (Australia)

2017-02-01

We infer dark matter properties from gamma ray residuals extracted using eight different interstellar emission scenarios proposed by the Fermi-LAT Collaboration to explain the Galactic Center gamma ray excess. Adopting the most plausible simplified ansatz, we assume that the dark matter particle is a Majorana fermion interacting with standard fermions via a scalar mediator. To trivially respect flavor constraints, we only couple the mediator to third generation fermions. Using this theoretical hypothesis, and the Fermi residuals, we calculate Bayesian evidences, including Fermi-LAT exclusion limits from 15 dwarf spheroidal galaxies as well. Our evidence ratios single out one of the Fermi scenarios as most compatible with the simplified dark matter model. In this scenario the dark matter (mediator) mass is in the 25-200 (1-1000) GeV range and its annihilation is dominated by bottom quark final state. Our conclusion is that the properties of dark matter extracted from gamma ray data are highly sensitive to the modeling of the interstellar emission.

HESS J1640–465 AND HESS J1641–463: TWO INTRIGUING TeV SOURCES IN LIGHT OF NEW FERMI-LAT OBSERVATIONS

Energy Technology Data Exchange (ETDEWEB)

Lemoine-Goumard, M.; Grondin, M.-H.; Laffon, H.; Reposeur, T. [Centre d' Études Nucléaires de Bordeaux Gradignan, IN2P3/CNRS, Université Bordeaux 1, BP120, F-33175 Gradignan Cedex (France); Acero, F.; Ballet, J., E-mail: lemoine@cenbg.in2p3.fr, E-mail: grondin@cenbg.in2p3.fr [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d' Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France)

2014-10-10

We report on γ-ray analysis of the region containing the bright TeV source HESS J1640–465 and the close-by TeV source HESS J1641–463 using 64 months of observations with the Fermi Large Area Telescope (LAT). Previously only one GeV source was reported in this region and was associated with HESS J1640–465. With an increased data set and the improved sensitivity afforded by the reprocessed data (P7REP) of the LAT, we now report the detection, morphological study, and spectral analysis of two distinct sources above 100 MeV. The softest emission in this region comes from the TeV source HESS J1641–463 which is well fitted with a power law of index Γ = 2.47 ± 0.05 ± 0.06 and presents no significant γ-ray signal above 10 GeV, which contrasts with its hard spectrum at TeV energies. The Fermi-LAT spectrum of the second TeV source, HESS J1640–465 is well described by a power-law shape of index Γ = 1.99 ± 0.04 ± 0.07 that links up naturally with the spectral data points obtained by the High Energy Stereoscopic System (H.E.S.S.). These new results provide new constraints concerning the identification of these two puzzling γ-ray sources.

HESS J1640–465 AND HESS J1641–463: TWO INTRIGUING TeV SOURCES IN LIGHT OF NEW FERMI-LAT OBSERVATIONS

International Nuclear Information System (INIS)

Lemoine-Goumard, M.; Grondin, M.-H.; Laffon, H.; Reposeur, T.; Acero, F.; Ballet, J.

2014-01-01

We report on γ-ray analysis of the region containing the bright TeV source HESS J1640–465 and the close-by TeV source HESS J1641–463 using 64 months of observations with the Fermi Large Area Telescope (LAT). Previously only one GeV source was reported in this region and was associated with HESS J1640–465. With an increased data set and the improved sensitivity afforded by the reprocessed data (P7REP) of the LAT, we now report the detection, morphological study, and spectral analysis of two distinct sources above 100 MeV. The softest emission in this region comes from the TeV source HESS J1641–463 which is well fitted with a power law of index Γ = 2.47 ± 0.05 ± 0.06 and presents no significant γ-ray signal above 10 GeV, which contrasts with its hard spectrum at TeV energies. The Fermi-LAT spectrum of the second TeV source, HESS J1640–465 is well described by a power-law shape of index Γ = 1.99 ± 0.04 ± 0.07 that links up naturally with the spectral data points obtained by the High Energy Stereoscopic System (H.E.S.S.). These new results provide new constraints concerning the identification of these two puzzling γ-ray sources

LatY136F knock-in mouse model for human IgG4-related disease.

Science.gov (United States)

Yamada, Kazunori; Zuka, Masahiko; Ito, Kiyoaki; Mizuguchi, Keishi; Kakuchi, Yasushi; Onoe, Tamehito; Suzuki, Yasunori; Yamagishi, Masakazu; Izui, Shozo; Malissen, Marie; Malissen, Bernard; Kawano, Mitsuhiro

2018-01-01

The adaptor protein Linker for activation of T cell (LAT) is a key signaling hub used by the T cell antigen receptor. Mutant mice expressing loss-of-function mutations affecting LAT and including a mutation in which tyrosine 136 is replaced by a phenylalanine (LatY136F) develop lymphoproliferative disorder involving T helper type 2 effector cells capable of triggering a massive polyclonal B cell activation that leads to hypergammaglobulinemia G1 and E and to non-resolving inflammation and autoimmunity. The purpose of this study was to evaluate whether the phenotypes of LatY136F knock-in mice resemble the immunohistopathological features of immunoglobulin G4-related disease (IgG4-RD). LatY136F knock-in mice were sacrificed at 4-20 weeks of age, and pancreas, kidney, salivary gland and lung were obtained. All organs were stained with hematoxylin-eosin and with Azan for estimation of collagen in fibrosis, and the severity scores of inflammation and fibrosis were evaluated. Immunostainings were performed to analyze the types of infiltrating cells. In addition, the effects of corticosteroid treatment on the development of tissue lesions and serum levels of IgG1 were assessed. Tissue lesions characterized by inflammatory mononuclear cell infiltration and fibrosis were detected in pancreas, kidney, and salivary gland starting from 6 weeks of age. Immunostainings showed pronounced infiltration of plasma cells, CD4-positive T cells, and macrophages. Infiltrating plasma cells predominantly expressed IgG1. The extent of inflammation in pancreas and salivary glands was markedly reduced by corticosteroid treatment. LatY136F knock-in mice displayed increased production of Th2-type IgG1 (a homologue of human IgG4) and developed multiple organ tissue lesions reminiscent of those seen in patients with IgG4-RD. Moreover, the development of these tissue lesions was highly sensitive to corticosteroid treatment like in IgG4-RD. For these reasons we consider the LatY136F knock-in mouse

DISCOVERY OF γ -RAY EMISSION FROM THE RADIO-INTERMEDIATE QUASAR III ZW 2: VIOLENT JET ACTIVITY WITH INTRADAY γ -RAY VARIABILITY

Energy Technology Data Exchange (ETDEWEB)

Liao, Neng-Hui; Xin, Yu-Liang; Fan, Yi-Zhong [Key Laboratory of Dark Matter and Space Astronomy, Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China); Fan, Xu-Liang [Graduate University of Chinese Academy of Sciences, Yuquan Road 19, Beijing 100049 (China); Weng, Shan-Shan [Department of Physics, Nanjing Normal University, Nanjing 210046 (China); Li, Shao-Kun [Key Laboratory for the Structure and Evolution of Celestial Objects, Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China); Chen, Liang, E-mail: liaonh@pmo.ac.cn, E-mail: yzfan@pmo.ac.cn [Key Laboratory for Research in Galaxies and Cosmology, Shanghai Astronomical Observatory, Chinese Academy of Sciences, 80 Nandan Road, Shanghai 200030 (China)

2016-10-01

III Zw 2 is the prototype of radio-intermediate quasars. Although there is the evidence of possessing strong jet, significant γ -ray emission has not been reported before. In this work, we carry out a detailed analysis of the latest Fermi -LAT Pass  8 data. No significant γ -ray signal has been detected in the time-averaged 7-year Fermi -LAT data of III Zw 2; however, we have identified two distinct γ -ray flares with isotropic luminosities of ∼10{sup 45} erg s{sup −1}. Multiwavelength data analysis (also including the optical photometric observations from Yunnan Observatories) are presented and the main finding is simultaneous optical and γ -ray flares of III Zw 2 appearing in 2009 November. Violent γ -ray variability with a doubling timescale of 2.5 hr was detected in another γ -ray flare in May 2010, for which the 3-hr γ -ray peak flux is ∼250 times of the average flux in 7 years. Rather similar behaviors are observed in blazars and the blazar model can reasonably reproduce the spectral energy distribution of III Zw 2 in a wide energy range, strongly suggesting that its central engine resembles that of blazars. In view of its core, which shares radio similarities with young radio sources, together with weak extended radio lobe emission, we suggest that III Zw 2 harbors a recurrent activity core and thus serves as a valuable target for investigating the fueling and triggering of the activity in radio-loud active galactic nuclei.

Pulsar Timing with the Fermi LAT

Science.gov (United States)

2010-12-01

Pulsar Timing with the Fermi LAT Paul S. Ray∗, Matthew Kerr†, Damien Parent∗∗ and the Fermi PSC‡ ∗Naval Research Laboratory, 4555 Overlook Ave., SW...Laboratory, Washington, DC 20375, USA ‡Fermi Pulsar Search Consortium Abstract. We present an overview of precise pulsar timing using data from the Large...unbinned photon data. In addition to determining the spindown behavior of the pulsars and detecting glitches and timing noise, such timing analyses al

Rapid variability of blazar 3C 279 during flaring states in 2013-2014 with joint FERMI-LAT, NuSTAR, swift, and ground-based multi-wavelength observations

DEFF Research Database (Denmark)

Hayashida, M.; Nalewajko, K.; Madejski, G. M.

2015-01-01

We report the results of a multiband observing campaign on the famous blazar 3C 279 conducted during a phase of increased activity from 2013 December to 2014 April, including first observations of it with NuSTAR. The γ-ray emission of the source measured by Fermi-LAT showed multiple distinct flar...

US biofuels subsidies and CO2 emissions: An empirical test for a weak and a strong green paradox

International Nuclear Information System (INIS)

Grafton, R. Quentin; Kompas, Tom; Long, Ngo Van; To, Hang

2014-01-01

Using energy data over the period 1981–2011 we find that US biofuels subsidies and production have provided a perverse incentive for US fossil fuel producers to increase their rate of extraction that has generated a weak green paradox. Further, in the short-run if the reduction in the CO 2 emissions from a one-to-one substitution between biofuels and fossil fuels is less than 26 percent, or less than 57 percent if long run effect is taken into account, then US biofuels production is likely to have resulted in a strong green paradox. These results indicate that subsidies for first generation biofuels, which yield a low level of per unit CO 2 emission reduction compared to fossil fuels, might have contributed to additional net CO 2 emissions over the study period. - Highlights: • US biofuels subsidies increased fossil fuel extraction from 1981 to 2011. • US biofuels subsidies likely increased carbon emissions from 1981 to 2011. • Governments must consider effects of biofuel subsidies on fossil fuel extraction

Steep Hard-X-ray Spectra Indicate Extremely High Accretion Rates in Weak Emission-Line Quasars

Science.gov (United States)

Marlar, Andrea; Shemmer, Ohad; Anderson, Scott F.; Brandt, W. Niel; Diamond-Stanic, Aleksandar M.; Fan, Xiaohui; Luo, Bin; Plotkin, Richard; Richards, Gordon T.; Schneider, Donald P.; Wu, Jianfeng

2018-06-01

We present XMM-Newton imaging spectroscopy of ten weak emission-line quasars (WLQs) at 0.928 ≤ z ≤ 3.767, six of which are radio quiet and four which are radio intermediate. The new X-ray data enabled us to measure the hard-X-ray power-law photon index (Γ) in each source with relatively high accuracy. These measurements allowed us to confirm previous reports that WLQs have steeper X-ray spectra, therefore indicating higher accretion rates with respect to "typical" quasars. A comparison between the Γ values of our radio-quiet WLQs and those of a carefully-selected, uniform sample of 84 quasars shows that the first are significantly higher, at the ≥ 3σ level. Collectively, the four radio-intermediate WLQs have lower Γ values with respect to the six radio-quiet WLQs, as may be expected if the spectra of the first group are contaminated by X-ray emission from a jet. These results suggest that, in the absence of significant jet emission along our line of sight, WLQs constitute the extreme high end of the accretion rate distribution in quasars. We detect soft excess emission in our lowest-redshift radio-quiet WLQ, in agreement with previous findings suggesting that the prominence of this feature is associated with a high accretion rate. We have not detected signatures of Compton reflection, Fe Kα lines, or strong variability between two X-ray epochs in any of our WLQs.

Gamma-ray Emission from Globular Clusters

Directory of Open Access Journals (Sweden)

Pak-Hin T. Tam

2016-03-01

Full Text Available Over the last few years, the data obtained using the Large Area Telescope (LAT aboard the Fermi Gamma-ray Space Telescope has provided new insights on high-energy processes in globular clusters, particularly those involving compact objects such as MilliSecond Pulsars (MSPs. Gamma-ray emission in the 100 MeV to 10 GeV range has been detected from more than a dozen globular clusters in our galaxy, including 47 Tucanae and Terzan 5. Based on a sample of known gammaray globular clusters, the empirical relations between gamma-ray luminosity and properties of globular clusters such as their stellar encounter rate, metallicity, and possible optical and infrared photon energy densities, have been derived. The measured gamma-ray spectra are generally described by a power law with a cut-off at a few gigaelectronvolts. Together with the detection of pulsed γ-rays from two MSPs in two different globular clusters, such spectral signature lends support to the hypothesis that γ-rays from globular clusters represent collective curvature emission from magnetospheres of MSPs in the clusters. Alternative models, involving Inverse-Compton (IC emission of relativistic electrons that are accelerated close to MSPs or pulsar wind nebula shocks, have also been suggested. Observations at >100 GeV by using Fermi/LAT and atmospheric Cherenkov telescopes such as H.E.S.S.-II, MAGIC-II, VERITAS, and CTA will help to settle some questions unanswered by current data.

A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (LAT1): A pilot study in a canine model

International Nuclear Information System (INIS)

Fukumoto, Shinya; Hanazono, Kiwamu; Fu, Dah-Renn; Endo, Yoshifumi; Kadosawa, Tsuyoshi; Iwano, Hidetomo; Uchide, Tsuyoshi

2013-01-01

Highlights: •LAT1 is highly expressed in tumors but at low levels in normal tissues. •We examine LAT1 expression and function in malignant melanoma (MM). •LAT1 expression in MM tissues and cell lines is higher than those in normal tissues. •LAT1 selective inhibitors inhibit amino acid uptake and cell growth in MM cells. •New chemotherapeutic protocols including LAT1 inhibitors are effective for treatment. -- Abstract: L-type amino acid transporter 1 (LAT1), an isoform of amino acid transport system L, transports branched or aromatic amino acids essential for fundamental cellular activities such as cellular growth, proliferation and maintenance. This amino acid transporter recently has received attention because of its preferential and up-regulated expression in a variety of human tumors in contrast to its limited distribution and low-level expression in normal tissues. In this study, we explored the feasibility of using LAT1 inhibitor as a new therapeutic agent for human malignant melanomas (MM) using canine spontaneous MM as a model for human MM. A comparative study of LAT expression was performed in 48 normal tissues, 25 MM tissues and five cell lines established from MM. The study observed LAT1 mRNA levels from MM tissues and cell lines that were significantly (P 3 H]L-Leucine uptake and cellular growth activities in CMeC-1 were inhibited in a dose-dependent manner by selective LAT1 inhibitors (2-amino-2-norbornane-carboxylic acid, BCH and melphalan, LPM). Inhibitory growth activities of various conventional anti-cancer drugs, including carboplatin, cyclophosphamide, dacarbazine, doxorubicin, mitoxantrone, nimustine, vinblastine and vincristine, were significantly (P < 0.05) enhanced by combination use with BCH or LPM. These findings suggest that LAT1 could be a new therapeutic target for MM

A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (LAT1): A pilot study in a canine model

Energy Technology Data Exchange (ETDEWEB)

Fukumoto, Shinya; Hanazono, Kiwamu [Veterinary Internal Medicine, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501 (Japan); Fu, Dah-Renn; Endo, Yoshifumi; Kadosawa, Tsuyoshi [Veterinary Oncology, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501 (Japan); Iwano, Hidetomo [Veterinary Biochemistry, Department of Basic Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501 (Japan); Uchide, Tsuyoshi, E-mail: uchide@rakuno.ac.jp [Veterinary Internal Medicine, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501 (Japan)

2013-09-13

Highlights: •LAT1 is highly expressed in tumors but at low levels in normal tissues. •We examine LAT1 expression and function in malignant melanoma (MM). •LAT1 expression in MM tissues and cell lines is higher than those in normal tissues. •LAT1 selective inhibitors inhibit amino acid uptake and cell growth in MM cells. •New chemotherapeutic protocols including LAT1 inhibitors are effective for treatment. -- Abstract: L-type amino acid transporter 1 (LAT1), an isoform of amino acid transport system L, transports branched or aromatic amino acids essential for fundamental cellular activities such as cellular growth, proliferation and maintenance. This amino acid transporter recently has received attention because of its preferential and up-regulated expression in a variety of human tumors in contrast to its limited distribution and low-level expression in normal tissues. In this study, we explored the feasibility of using LAT1 inhibitor as a new therapeutic agent for human malignant melanomas (MM) using canine spontaneous MM as a model for human MM. A comparative study of LAT expression was performed in 48 normal tissues, 25 MM tissues and five cell lines established from MM. The study observed LAT1 mRNA levels from MM tissues and cell lines that were significantly (P < 0.01) higher than in normal tissues. Additionally, MM with distant metastasis showed a higher expression than those without distant metastasis. Functional analysis of LAT1 was performed on one of the five cell lines, CMeC-1. [{sup 3}H]L-Leucine uptake and cellular growth activities in CMeC-1 were inhibited in a dose-dependent manner by selective LAT1 inhibitors (2-amino-2-norbornane-carboxylic acid, BCH and melphalan, LPM). Inhibitory growth activities of various conventional anti-cancer drugs, including carboplatin, cyclophosphamide, dacarbazine, doxorubicin, mitoxantrone, nimustine, vinblastine and vincristine, were significantly (P < 0.05) enhanced by combination use with BCH or LPM

17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway

Science.gov (United States)

Ye, Xiang-Yun; Luo, Qing-Quan; Xu, Yun-Hua; Tang, Nai-Wang; Niu, Xiao-Min; Li, Zi-Ming; Shen, Sheng-Ping; Lu, Shun; Chen, Zhi-Wei

2015-01-01

The large tumour suppressor 1 (LATS1) signalling network has been proved to be an essential regulator within the cell, participating in multiple cellular phenotypes. However, it is unclear concerning the clinical significance of LATS1 and the regulatory mechanisms of 17-Allylamino-17- demethoxygeldanamycin (17-AAG) in lung adenocarcinoma (LAC). The aim of the present study was to investigate the correlation of LATS1 and yes-associated protein (YAP) expression with clinicopathological characteristics in LAC patients, and the effects of 17-AAG on biological behaviours of LAC cells. Subcutaneous LAC tumour models were further established to observe the tumour growth in nude mice. The results showed that the positive expression of LATS1 was significantly lowered (26.7% versus 68.0%, P AAG inhibited proliferation and invasion, and induced cell apoptosis and cycle arrest in LAC cells together with increased expression of E-cadherin and p-LATS1, and decreased expression of YAP and connective tissue growth factor. Tumour volumes and weight were much smaller in 17-AAG-treated groups than those in untreated group (P AAG suppresses growth and invasion of LAC cells via regulation of the LATS1/YAP pathway in vitro and in vivo, suggesting that we may provide a promising therapeutic strategy for the treatment of human LAC. PMID:25712415

Cap and trade schemes on waste management: A case study of the Landfill Allowance Trading Scheme (LATS) in England

International Nuclear Information System (INIS)

Calaf-Forn, Maria; Roca, Jordi; Puig-Ventosa, Ignasi

2014-01-01

Highlights: • LATS has been effective to achieve a reduction of the amount of landfilled waste. • LATS has been one of the few environmental instruments for waste management with a cap and trade methodology. • LATS has achieved to increase recycling of the biodegradable and other waste fractions. - Abstract: The Landfill Allowance Trading Scheme (LATS) is one of the main instruments used in England to enforce the landfill diversion targets established in the Directive 1999/31/EC of the European Parliament and of the Council of 26 April 1999 on the landfill of waste (Landfill Directive). Through the LATS, biodegradable municipal waste (BMW) allowances for landfilling are allocated to each local authority, otherwise known as waste disposal authorities (WDAs). The quantity of landfill allowances received is expected to decrease continuously from 2005/06 to 2019/20 so as to meet the objectives of the Landfill Directive. To achieve their commitments, WDAs can exchange, buy, sell or transfer allowances among each other, or may re-profile their own allocation through banking and/or borrowing. Despite the goals for the first seven years – which included two target years (2005/06 and 2009/10) – being widely achieved (the average allocation of allowances per WDA was 22.9% higher than those finally used), market activity among WDAs was high and prices were not very stable. Results in terms of waste reduction and recycling levels have been satisfactory. The reduction of BMW landfilled (in percentage) was higher during the first seven years of the LATS period (2005/06–2011/12) (around 7% annually) than during the previous period (2001/02–2004/05) (4.2% annually). Since 2008, the significance of the LATS diminished because of an increase in the rate of the UK Landfill Tax. The LATS was suppressed after the 2012/13 target year, before what it was initially scheduled. The purpose of this paper is to describe the particularities of the LATS, analyse its performance as

Cap and trade schemes on waste management: A case study of the Landfill Allowance Trading Scheme (LATS) in England

Energy Technology Data Exchange (ETDEWEB)

Calaf-Forn, Maria, E-mail: mcalaf@ent.cat [Institut de Ciència i Tecnologia Ambientals (ICTA), Universitat Autònoma de Barcelona (UAB), E-08193 Bellaterra, Barcelona (Spain); ENT Environment and Management, Carrer Sant Joan 39, First Floor, E-08800 Vilanova i la Geltrú, Barcelona (Spain); Roca, Jordi [Departament de Teoria Econòmica, Universitat de Barcelona (UB), Diagonal, 696, E-08034 Barcelona (Spain); Puig-Ventosa, Ignasi [ENT Environment and Management, Carrer Sant Joan 39, First Floor, E-08800 Vilanova i la Geltrú, Barcelona (Spain)

2014-05-01

Highlights: • LATS has been effective to achieve a reduction of the amount of landfilled waste. • LATS has been one of the few environmental instruments for waste management with a cap and trade methodology. • LATS has achieved to increase recycling of the biodegradable and other waste fractions. - Abstract: The Landfill Allowance Trading Scheme (LATS) is one of the main instruments used in England to enforce the landfill diversion targets established in the Directive 1999/31/EC of the European Parliament and of the Council of 26 April 1999 on the landfill of waste (Landfill Directive). Through the LATS, biodegradable municipal waste (BMW) allowances for landfilling are allocated to each local authority, otherwise known as waste disposal authorities (WDAs). The quantity of landfill allowances received is expected to decrease continuously from 2005/06 to 2019/20 so as to meet the objectives of the Landfill Directive. To achieve their commitments, WDAs can exchange, buy, sell or transfer allowances among each other, or may re-profile their own allocation through banking and/or borrowing. Despite the goals for the first seven years – which included two target years (2005/06 and 2009/10) – being widely achieved (the average allocation of allowances per WDA was 22.9% higher than those finally used), market activity among WDAs was high and prices were not very stable. Results in terms of waste reduction and recycling levels have been satisfactory. The reduction of BMW landfilled (in percentage) was higher during the first seven years of the LATS period (2005/06–2011/12) (around 7% annually) than during the previous period (2001/02–2004/05) (4.2% annually). Since 2008, the significance of the LATS diminished because of an increase in the rate of the UK Landfill Tax. The LATS was suppressed after the 2012/13 target year, before what it was initially scheduled. The purpose of this paper is to describe the particularities of the LATS, analyse its performance as

Constraints on the bulk Lorentz factor of gamma-ray bursts with the detection rate by Fermi LAT

Science.gov (United States)

Chen, Ye; Liu, Ruo-Yu; Wang, Xiang-Yu

2018-05-01

The bulk Lorentz factor(Γ) of the outflow is an essential parameter to understanding the physics of gamma-ray burst (GRB). Informations about the Lorentz factors of some individual GRBs have been obtained from the spectral features of the high-energy gamma-ray emissions (>100 MeV), assuming that the spectral breaks or cutoffs are due to the pair-production attenuation (i.e., γγ → e+e-). In this paper, we attempt to interpret the dependence of the LAT detection rate of GRBs on the number of high-energy gamma-rays, taking into account the attenuation effect. We first simulate a long-GRB sample with Monte Carlo method using the luminosity function, rate distribution with redshift and properties of the GRB spectrum. To characterize the distribution of the Lorentz factors, we assume that the Lorentz factors follow the relation Γ =Γ _0E_iso,52k, where Eiso, 52 is the isotropic photon energy in unit of 1052erg. After taking into account the attenuation effect related with the above Lorentz factor distribution, we are able to reproduce the LAT-detected rate of GRBs as the function of the number of gamma-rays for suitable choice of the values of Γ0 and k. The result suggests that the distribution of the bulk Lorentz factor for the majority of GRBs is in the range of 50 - 250.

Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.

Directory of Open Access Journals (Sweden)

Ambarish Nag

Full Text Available The linker for activation of T cells (LAT, the linker for activation of B cells (LAB, and the linker for activation of X cells (LAX form a family of transmembrane adaptor proteins widely expressed in lymphocytes. These scaffolding proteins have multiple binding motifs that, when phosphorylated, bind the SH2 domain of the cytosolic adaptor Grb2. Thus, the valence of LAT, LAB and LAX for Grb2 is variable, depending on the strength of receptor activation that initiates phosphorylation. During signaling, the LAT population will exhibit a time-varying distribution of Grb2 valences from zero to three. In the cytosol, Grb2 forms 1:1 and 2:1 complexes with the guanine nucleotide exchange factor SOS1. The 2:1 complex can bridge two LAT molecules when each Grb2, through their SH2 domains, binds to a phosphorylated site on a separate LAT. In T cells and mast cells, after receptor engagement, receptor phosphoyrlation is rapidly followed by LAT phosphorylation and aggregation. In mast cells, aggregates containing more than one hundred LAT molecules have been detected. Previously we considered a homogeneous population of trivalent LAT molecules and showed that for a range of Grb2, SOS1 and LAT concentrations, an equilibrium theory for LAT aggregation predicts the formation of a gel-like phase comprising a very large aggregate (superaggregate. We now extend this theory to investigate the effects of a distribution of Grb2 valence in the LAT population on the formation of LAT aggregates and superaggregate and use stochastic simulations to calculate the fraction of the total LAT population in the superaggregate.

17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway.

Science.gov (United States)

Ye, Xiang-Yun; Luo, Qing-Quan; Xu, Yun-Hua; Tang, Nai-Wang; Niu, Xiao-Min; Li, Zi-Ming; Shen, Sheng-Ping; Lu, Shun; Chen, Zhi-Wei

2015-03-01

The large tumour suppressor 1 (LATS1) signalling network has been proved to be an essential regulator within the cell, participating in multiple cellular phenotypes. However, it is unclear concerning the clinical significance of LATS1 and the regulatory mechanisms of 17-Allylamino-17- demethoxygeldanamycin (17-AAG) in lung adenocarcinoma (LAC). The aim of the present study was to investigate the correlation of LATS1 and yes-associated protein (YAP) expression with clinicopathological characteristics in LAC patients, and the effects of 17-AAG on biological behaviours of LAC cells. Subcutaneous LAC tumour models were further established to observe the tumour growth in nude mice. The results showed that the positive expression of LATS1 was significantly lowered (26.7% versus 68.0%, P AAG inhibited proliferation and invasion, and induced cell apoptosis and cycle arrest in LAC cells together with increased expression of E-cadherin and p-LATS1, and decreased expression of YAP and connective tissue growth factor. Tumour volumes and weight were much smaller in 17-AAG-treated groups than those in untreated group (P AAG suppresses growth and invasion of LAC cells via regulation of the LATS1/YAP pathway in vitro and in vivo, suggesting that we may provide a promising therapeutic strategy for the treatment of human LAC. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Diffuse γ-ray emission from misaligned active galactic nuclei

Energy Technology Data Exchange (ETDEWEB)

Di Mauro, M.; Donato, F. [Physics Department, Torino University, and Istituto Nazionale di Fisica Nucleare, Sezione di Torino, via Giuria 1, I-10125 Torino (Italy); Calore, F. [II. Institute for Theoretical Physics, University of Hamburg, Luruper Chaussee 149, D-22761 Hamburg (Germany); Ajello, M. [Space Sciences Laboratory, University of California, Berkeley, CA 94720 (United States); Latronico, L., E-mail: donato@to.infn.it [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, via Giuria 1, I-10125 Torino (Italy)

2014-01-10

Active galactic nuclei (AGNs) with jets seen at small viewing angles are the most luminous and abundant objects in the γ-ray sky. AGNs with jets misaligned along the line of sight appear fainter in the sky but are more numerous than the brighter blazars. We calculate the diffuse γ-ray emission due to the population of misaligned AGNs (MAGNs) unresolved by the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope (Fermi). A correlation between the γ-ray luminosity and the radio-core luminosity is established and demonstrated to be physical by statistical tests, as well as compatible with upper limits based on Fermi-LAT data for a large sample of radio-loud MAGNs. We constrain the derived γ-ray luminosity function by means of the source-count distribution of the radio galaxies detected by the Fermi-LAT. We finally calculate the diffuse γ-ray flux due to the whole MAGN population. Our results demonstrate that MAGNs can contribute from 10% up to nearly the entire measured isotropic gamma-ray background. We evaluate a theoretical uncertainty on the flux of almost an order of magnitude.

Measurements of the cosmic-ray electron and positron spectrum and anisotropies with the Fermi LAT

Science.gov (United States)

Loparco, F.; Fermi LAT Collaboration

2017-12-01

The Large Area Telescope (LAT) onboard the Fermi satellite is a pair-conversion telescope for high-energy gamma rays of astrophysical origin. Although it was designed to be a high-sensitivity gamma-ray telescope, the LAT has proved to be an excellent electron/positron detector. It has been operating in low Earth orbit since June 2008 and has collected more than 16 million cosmic-ray electron and positron (CRE) events in its first seven years of operation. The huge data sample collected by the LAT enables a precise measurement of the CRE energy spectrum up to the TeV region. A search for anisotropies in the arrival directions of CREs was also performed. The upper limits on the dipole anisotropy probe the presence of nearby young and middle-aged CRE sources.

LAT Perspectives in Detection of High Energy Cosmic Ray Electrons

International Nuclear Information System (INIS)

Moiseev, Alexander; Ormes, J.F.; Funk, Stefan

2007-01-01

The LAT science objectives and capabilities in the detection of high energy electrons in the energy range from 20 GeV to ∼1.5 TeV are presented. LAT simulations are used to establish the event selections. It is found that maintaining the efficiency of electron detection at the level of 30%, the residual hadron contamination does not exceed 2-3% of the electron flux. It is expected to collect ∼ ten million of electrons with the energy above 20 GeV for one year of observation. Precise spectrum reconstruction with collected electron statistics opens the unique opportunity to investigate several important problems such as models of IC radiation, revealing the signatures of nearby sources such as high energy cutoff in the electron spectrum, testing the propagation model, and search for KKDM particles decay through their contribution to the electron spectrum

Weak Disposability in Nonparametric Production Analysis with Undesirable Outputs

NARCIS (Netherlands)

Kuosmanen, T.K.

2005-01-01

Environmental Economics and Natural Resources Group at Wageningen University in The Netherlands Weak disposability of outputs means that firms can abate harmful emissions by decreasing the activity level. Modeling weak disposability in nonparametric production analysis has caused some confusion.

The Half-Life of the HSV-1 1.5 kb LAT Intron is similar to the half-Life of the 2.0 kb LAT Intron

Science.gov (United States)

Brinkman, Kerry K.; Mishra, Prakhar; Fraser, Nigel W.

2013-01-01

Herpes Simplex Virus type 1 (HSV-1) establishes a latent infection in the sensory neurons of the peripheral nervous system of humans. Although about 80 genes are expressed during the lytic cycle of the virus infection, essentially only one gene is expressed during the latent cycle. This gene is known as the latency associated transcript (LAT) and it appears to play a role in the latency cycle through an anti-apoptotic function in the 5’ end of the gene and miRNA encoded along the length of the transcript which down regulate some of the viral immediate early (IE) gene products. The LAT gene is about 8.3 kb long and consists of two exons separated by an unusual intron. The intron between the exons consists of two nested introns. This arrangement of introns has been called a twintron. Furthermore, the larger (2 kb) intron has been shown to be very stable. In this study we measure the stability of the shorter 1.5 kb nested intron and find its half-life is similar to the longer intron. This was achieved by deleting the 0.5 kb overlapping intron from a plasmid construct designed to express the LAT transcript from a tet-inducible promoter, and measuring the half-life of the 1.5 kb intron in tissue culture cells. This finding supports the hypothesis that it is the common branch-point region of these nested introns that is responsible for their stability. PMID:23335177

Potencial evocado auditivo de longa latência: diferenças na forma de contagem do estímulo raro

Directory of Open Access Journals (Sweden)

Rubia Soares Bruno

2016-02-01

Full Text Available RESUMO Objetivo: identificar se existe diferença nos achados do Potencial Evocado Auditivo de Longa Latência em relação à latência e amplitude, em diferentes modos de contagem do estimulo raro, sendo contando mentalmente ou marcando no papel (sem memorizar. Métodos: esse estudo teve caráter prospectivo e transversal. A amostra foi composta por conveniência sendo constituída por 49 indivíduos, sendo 29 do gênero feminino e 20 do gênero masculino. Foram realizados os seguintes procedimentos: Inspeção Visual do Meato Acústico Externo, Audiometria Tonal Liminar, Medidas de Imitância Acústica e Potencial Evocado Auditivo de Longa Latência, o qual foi realizado duas vezes, uma após a outra, com os indivíduos atentando ao estímulo raro, começando sempre contando mentalmente e após marcando em um papel. Resultados: houve diferença estatisticamente significante entre as orelhas para as latências de P1, P2 e amplitude de N1 para o método de marcação no papel, da latência de N1 para o método de contagem mental dos estímulos raros, e da amplitude de P2 em ambos os métodos, porém com todos os valores dentro da faixa de normalidade. Além disso, a diferença estatisticamente significante também foi evidente na comparação entre os gêneros, sendo encontrados valores de latência maiores de P2 e N2 para o gênero masculino em ambos os métodos de contagem dos estímulos raros. A amplitude de P1, P2 e P3 foi menor no gênero masculino nas diferentes formas de contagem, sendo no P2 a diferença apenas no método contando mentalmente. Ao compararmos os métodos, houve diferença estatisticamente significante apenas para a latência de P2, a qual foi maior para o método marcando no papel. Conclusão: não houve diferença para as latências e amplitudes dos potenciais evocados auditivos de longa latência na comparação da contagem do estímulo raro (contando mentalmente e marcando no papel para quase todos os potenciais, com

A search for neutrino emission from the Fermi bubbles with the ANTARES telescope

NARCIS (Netherlands)

Adrian-Martinez, S.; Albert, A.; Al Samarai, I.; Andre, M.; Anton, G.; Anvar, S.; Ardid, M.; Astraatmadja, T.; Aubert, J.J.; Baret, B.; Barrios-Marti, J.; Basa, S.; Bertin, V.; Biagi, S.; Bigongiari, C.; Bogazzi, C.; Bouhou, B.; Bouwhuis, M.; Brunner, J.; Busto, J.; Capone, A.; Caramete, L.; Carloganu, C.; Carr, J.; Cecchini, S.; Charif, Z.; Charvis, P.; Chiarusi, T.; Circella, M.; Classen, F.; Coniglione, R.; Core, L.; Costantini, H.; Coyle, P.; Creusot, A.; Curtil, C.; De Bonis, G.; Dekeyser, I.; Deschamps, A.; Donzaud, C.; Dornic, D.; Dorosti, Q.; Drouhin, D.; Dumas, A.; Eberl, T.; Emanuele, U.; Enzenhofer, A.; Ernenwein, J.P.; Escoffier, S.; Fehn, K.; Fermani, P.; Flaminio, V.; Folger, F.; Fritsch, U.; Fusco, L.; Galata, S.; Gay, P.; Geisselsoder, S.; Geyer, K.; Giacomelli, G.; Giordano, V.; Gleixner, A.; Gomez-Gonzalez, J.P.; Graf, K.; Guillard, G.; van Haren, H.; Heijboer, A.; Hello, Y.; Hernandez-Rey, J.; Herold, B.; Hossl, J.; Hugon, C.; James, C.; de Jong, M.; Kadler, M.; Kalekin, O.; Kappes, A.; Katz, U.; Kooijman, P.; Kouchner, A.; Kreykenbohm, I.; Kulikovskiy, V.; Lahmann, R.; Lambard, E.; Lambard, G.; Larosa, G.; Lattuada, D.; Lefevre, D.; Leonora, E.; Lo Presti, D.; Loehner, H.; Loucatos, S.; Louis, F.; Mangano, S.; Marcelin, M.; Margiotta, A.; Martinez-Mora, J.; Martini, S.; Michael, T.; Montaruli, T.; Morganti, M.; Muller, C.; Neff, M.; Nezri, E.; Palioselitis, D.; Pavalas, G.E.; Perrina, C.; Popa, V.; Pradier, T.; Racca, C.; Riccobene, G.; Richter, R.; Riviere, C.; Robert, A.; Roensch, K.; Rostovtsev, A.; Samtleben, D.; Sanguineti, M.; Sapienza, P.; Schmid, J.; Schnabel, J.; Schulte, S.; Schussler, F.; Seitz, T.; Shanidze, R.; Sieger, C.; Simeone, F.; Spies, A.; Spurio, M.; Steijger, J.; Stolarczyk, T.; Sanchez-Losa, A.; Taiuti, M.; Tamburini, C.; Tayalati, Y.; Trovato, A.; Vallage, B.; Vallee, C.; Van Elewyck, V.; Vecchi, M.; Vernin, P.; Visser, E.; Wagner, S.; Wilms, J.; de Wolf, E.; Yatkin, K.; Yepes, H.; Zornoza, J.; Zuniga, J.; the ANTARES Collaboration

2014-01-01

Analysis of the Fermi-LAT data has revealed two extended structures above and below the Galactic Centre emitting gamma rays with a hard spectrum, the so-called Fermi bubbles. Hadronic models attempting to explain the origin of the Fermi bubbles predict the emission of high-energy neutrinos and gamma

Search for cosmic-ray-induced gamma-ray emission in galaxy clusters

Energy Technology Data Exchange (ETDEWEB)

Ackermann, M.; Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Ajello, M. [Space Sciences Laboratory, 7 Gauss Way, University of California, Berkeley, CA 94720-7450 (United States); Albert, A. [Department of Physics, Center for Cosmology and Astro-Particle Physics, The Ohio State University, Columbus, OH 43210 (United States); Allafort, A.; Bechtol, K.; Bloom, E. D.; Bottacini, E. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Atwood, W. B. [Santa Cruz Institute for Particle Physics, Department of Physics and Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Baldini, L. [Università di Pisa and Istituto Nazionale di Fisica Nucleare, Sezione di Pisa I-56127 Pisa (Italy); Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d' Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D.; Buson, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bellazzini, R.; Bregeon, J. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bonamente, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Perugia, I-06123 Perugia (Italy); Brandt, T. J. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Brigida, M. [Dipartimento di Fisica " M. Merlin" dell' Università e del Politecnico di Bari, I-70126 Bari (Italy); Bruel, P., E-mail: olr@slac.stanford.edu, E-mail: zimmer@fysik.su.se, E-mail: conrad@fysik.su.se, E-mail: apinzke@fysik.su.se, E-mail: christoph.pfrommer@h-its.org [Laboratoire Leprince-Ringuet, École polytechnique, CNRS/IN2P3, F-91128 Palaiseau (France); Collaboration: Fermi-LAT Collaboration; and others

2014-05-20

Current theories predict relativistic hadronic particle populations in clusters of galaxies in addition to the already observed relativistic leptons. In these scenarios hadronic interactions give rise to neutral pions which decay into γ rays that are potentially observable with the Large Area Telescope (LAT) on board the Fermi space telescope. We present a joint likelihood analysis searching for spatially extended γ-ray emission at the locations of 50 galaxy clusters in four years of Fermi-LAT data under the assumption of the universal cosmic-ray (CR) model proposed by Pinzke and Pfrommer. We find an excess at a significance of 2.7σ, which upon closer inspection, however, is correlated to individual excess emission toward three galaxy clusters: A400, A1367, and A3112. We discuss these cases in detail and conservatively attribute the emission to unmodeled background systems (for example, radio galaxies within the clusters).Through the combined analysis of 50 clusters, we exclude hadronic injection efficiencies in simple hadronic models above 21% and establish limits on the CR to thermal pressure ratio within the virial radius, R {sub 200}, to be below 1.25%-1.4% depending on the morphological classification. In addition, we derive new limits on the γ-ray flux from individual clusters in our sample.

Leser-Trélat sign presenting in a patient with ovarian cancer: a case report

Directory of Open Access Journals (Sweden)

Bölke Edwin

2009-07-01

Full Text Available Abstract Introduction Seborrheic keratoses are very common findings in elderly patients. However, a sudden onset and dramatic increase in the number and size of these benign lesions deserves special attention, since this may represent the Leser Trélat sign, a rare paraneoplastic cutaneous syndrome. Case presentation A 92-year-old female presented to our clinic with multiple eruptive seborrheic keratoses, which had dramatically increased in size and number over the past two years. A diagnostic work-up revealed an ovarian carcinoma. Hence, cutaneous findings in our patient were consistent with the diagnosis of the Leser-Trélat sign. Conclusion The Leser-Trélat sign may coincide with the diagnosis of occult cancer or follow or precede it by months or years. Practitioners should take cases of eruptive seborrheic keratoses seriously and perform thorough patient examinations.

Constraints on the dark matter annihilation from Fermi-LAT observation of M31

Energy Technology Data Exchange (ETDEWEB)

Li, Zhengwei; Yuan, Qiang [Key Laboratory of Dark Matter and Space Astronomy, Purple Mountain Observatory, Chinese Academy of Sciences, 2 West Beijing Road, Nanjing, 210008 (China); Huang, Xiaoyuan [Physik-Department T30d, Technische Universität München, James-Franck-Straße, Garching, D-85748 Germany (Germany); Xu, Yupeng, E-mail: lizw@ihep.ac.cn, E-mail: huangxiaoyuan@gmail.com, E-mail: yuanq@pmo.ac.cn, E-mail: xuyp@ihep.ac.cn [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, 19B Yuquan Road, Beijing, 100049 (China)

2016-12-01

Gamma-ray is a good probe of dark matter (DM) particles in the Universe. We search for the DM annihilation signals in the direction of the Andromeda galaxy (M31) using 7.5 year Fermi-LAT pass 8 data. Similar to Pshirkov et al. (2016), we find that there is residual excess emission from the direction of M31 if only the galactic disk as traced by the far infrared emission is considered. Adding a point-like source will improve the fitting effectively, although additional slight improvements can be found if an extended component such as a uniform disk or two bubbles is added instead. Taking the far infrared disk plus a point source as the background model, we search for the DM annihilation signals in the data. We find that there is strong degeneracy between the emission from the galaxy and that from 10s GeV mass DM annihilation in the main halo with quark final state. However, the required DM annihilation cross section is about 10{sup −25}–10{sup −24} cm{sup 3}s{sup −1}, orders of magnitude larger than the constraints from observations of dwarf spheroidal galaxies, indicating a non-DM origin of the emission. If DM subhalos are taken into account, the degeneracy is broken. When considering the enhancement from DM subhalos, the constraints on DM model parameters are comparable to (or slightly weaker than) those from the population of dwarf spheroidal galaxies. We also discuss the inverse Compton scattering component from DM annihilation induced electrons/positrons. For the first time we include an energy dependent template of the inverse Compton emission (i.e., a template cube) in the data analysis to take into account the effect of diffusion of charged particles. We find a significant improvement of the constraints in the high mass range of DM particles after considering the inverse Compton emission.

Targeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: Toward a novel active targeting strategy in breast cancer therapy.

Science.gov (United States)

Li, Lin; Di, Xingsheng; Wu, Mingrui; Sun, Zhisu; Zhong, Lu; Wang, Yongjun; Fu, Qiang; Kan, Qiming; Sun, Jin; He, Zhonggui

2017-04-01

Designing active targeting nanocarriers with increased cellular accumulation of chemotherapeutic agents is a promising strategy in cancer therapy. Herein, we report a novel active targeting strategy based on the large amino acid transporter 1 (LAT1) overexpressed in a variety of cancers. Glutamate was conjugated to polyoxyethylene stearate as a targeting ligand to achieve LAT1-targeting PLGA nanoparticles. The targeting efficiency of nanoparticles was investigated in HeLa and MCF-7 cells. Significant increase in cellular uptake and cytotoxicity was observed in LAT1-targeting nanoparticles compared to the unmodified ones. More interestingly, the internalized LAT1 together with targeting nanoparticles could recycle back to the cell membrane within 3 h, guaranteeing sufficient transporters on cell membrane for continuous cellular uptake. The LAT1 targeting nanoparticles exhibited better tumor accumulation and antitumor effects. These results suggested that the overexpressed LAT1 on cancer cells holds a great potential to be a high-efficiency target for the rational design of active-targeting nanosystems. Copyright © 2016 Elsevier Inc. All rights reserved.

"Küsse lat's ..." : [luuletused] / Kauksi Ülle

Index Scriptorium Estoniae

Kauksi Ülle, pseud., 1962-

2002-01-01

Sisu: "Küsse lat's ..." ; "Vanaimä, ma lupa, ku suurõss kasu ..." ; "Mis-ti küsüt, et ..." ; Ussõ pääl üteld ; "Mis' sõs ku olõ 'pihlõ' ma kesk umma mäke ..." "Kos' sa olt? ..." ; "Maarahva miil ..." ; "Havvakirju ragi yts miis ..." ; Hanõ vai luigõ ; Võlg ; Mu viimäne laul sullõ ; "üts korgõ puu pak mullõ paika ...". Eluloolisi andmeid autori kohta lk. 369

Quantum squeezed state analysis of spontaneous ultra weak light photon emission of practitioners of meditation and control subjects.

Science.gov (United States)

Van Wijk, Eduard P A; Van Wijk, Roeland; Bajpai, Rajendra P

2008-05-01

Research on human ultra-weak photon emission (UPE) has suggested a typical human emission anatomic percentage distribution pattern. It was demonstrated that emission intensities are lower in long-term practitioners of meditation as compared to control subjects. The percent contribution of emission from different anatomic locations was not significantly different for meditation practitioners and control subjects. Recently, a procedure was developed to analyze the fluctuations in the signals by measuring probabilities of detecting different numbers of photons in a bin and correct these for background noise. The procedure was tested utilizing the signal from three different body locations of a single subject, demonstrating that probabilities have non-classical features and are well described by the signal in a coherent state from the three body sites. The values indicate that the quantum state of photon emitted by the subject could be a coherent state in the subject being investigated. The objective in the present study was to systematically quantify, in subjects with long-term meditation experience and subjects without this experience, the photon count distribution of 12 different locations. Data show a variation in quantum state parameters within each individual subject as well as variation in quantum state parameters between the groups.

The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1▿

Science.gov (United States)

Allen, Sariah J.; Hamrah, Pedram; Gate, David; Mott, Kevin R.; Mantopoulos, Dimosthenis; Zheng, Lixin; Town, Terrence; Jones, Clinton; von Andrian, Ulrich H.; Freeman, Gordon J.; Sharpe, Arlene H.; BenMohamed, Lbachir; Ahmed, Rafi; Wechsler, Steven L.; Ghiasi, Homayon

2011-01-01

Herpes simplex virus (HSV) infection is a classic example of latent viral infection in humans and experimental animal models. The HSV-1 latency-associated transcript (LAT) plays a major role in the HSV-1 latency reactivation cycle and thus in recurrent disease. Whether the presence of LAT leads to generation of dysfunctional T cell responses in the trigeminal ganglia (TG) of latently infected mice is not known. To address this issue, we used LAT-positive [LAT(+)] and LAT-deficient [LAT(−)] viruses to evaluate the effect of LAT on CD8 T cell exhaustion in TG of latently infected mice. The amount of latency as determined by quantitative reverse transcription-PCR (qRT-PCR) of viral DNA in total TG extracts was 3-fold higher with LAT(+) than with LAT(−) virus. LAT expression and increased latency correlated with increased mRNA levels of CD8, PD-1, and Tim-3. PD-1 is both a marker for exhaustion and a primary factor leading to exhaustion, and Tim-3 can also contribute to exhaustion. These results suggested that LAT(+) TG contain both more CD8+ T cells and more CD8+ T cells expressing the exhaustion markers PD-1 and Tim-3. This was confirmed by flow cytometry analyses of expression of CD3/CD8/PD-1/Tim-3, HSV-1, CD8+ T cell pentamer (specific for a peptide derived from residues 498 to 505 of glycoprotein B [gB498–505]), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-α). The functional significance of PD-1 and its ligands in HSV-1 latency was demonstrated by the significantly reduced amount of HSV-1 latency in PD-1- and PD-L1-deficient mice. Together, these results may suggest that both PD-1 and Tim-3 are mediators of CD8+ T cell exhaustion and latency in HSV-1 infection. PMID:21307196

Numerical simulation of sediment transport from Ba Lat Mouth and the process of coastal morphology

International Nuclear Information System (INIS)

Chung, Dang Huu

2008-01-01

This paper presents an application of a 3D numerical model to simulate one vertical layer sediment transport and coastal morphodynamical process for the Hai Hau coastal area located in the north of Vietnam, where a very large amount of suspended sediment is carried into the sea from Ba Lat Mouth every year. Four simulations are based on the real data of waves supplied by the observation station close to Ba Lat Mouth. The conditions of wind and suspended sand concentration at Ba Lat Mouth are basically assumed from practice. The computed results show that the hydrodynamic factors strongly depend on the wind condition and these factors govern the direction and the range of suspended sand transport, especially in the shallow-water region. In the deep-water region this influence is not really clear when the wind force is not strong enough to modify the tidal current. In the area close to Ba Lat Mouth the flow velocity is very large with the maximum flood flow about 2.6 m s −1 and the maximum ebb flow about 1 m s −1 at the mouth, and this is one of the reasons for strong erosion. In the case of tidal flow only, the suspended sand concentration decreases resulting in local deposition. Therefore, the area influenced by suspended transport is small, about 12 km from the mouth. In the condition of wind and waves, the suspended sand transport reaches the end of the computation area within a few days, especially the cases with wind from the north-east-north. Through these simulation results, a common tendency of sediment movement from the north to the south is specified for the Hai Hau coastal area. In addition, the results also show that the coast suffers from strong erosion, especially the region near Ba Lat Mouth. From the simulation results it can be seen that the movement of the Red River sand along the Vietnamese coast is quite possible, which is an answer to a long-standing question. Furthermore, although the suspended sediment concentration is quite large, it is

Constraining decaying dark matter with FERMI-LAT gamma rays

International Nuclear Information System (INIS)

Maccione, L.

2011-01-01

High energy electron sand positrons from decaying dark matter can produce a significant flux of gamma rays by inverse Compton of low energy photons in the interstellar radiation field. This possibility is inevitably related with the dark matter interpretation of the observed PAMELA and FERMI excesses. We will describe a simple and universal method to constrain dark matter models which produce electrons and positrons in their decay by using the FERMI-LAT gamma-ray observations in the energy range between 0.5 GeV and 300 GeV, by exploiting universal response functions that, once convolved with a specific dark matter model, produce the desired constraint. The response functions contain all the astrophysical inputs. Here is discussed the uncertainties in the determination of the response functions and apply them to place constraints on some specific dark matter decay models that can well fit the positron and electron fluxes observed by PAMELA and FERMI LAT, also taking into account prompt radiation from the dark matter decay. With the available data decaying dark matter can not be excluded as source of the PAMELA positron excess.

Blazards variability detected by the spatial Fermi-LAT telescope. Study of 3C454.3 and development of an optimised light curves generation method

International Nuclear Information System (INIS)

Escande, L.

2012-01-01

The Fermi Gamma-ray Space Telescope was launched on 2008 June 11, carrying the Large Area Telescope (LAT), sensitive to gamma-rays in the 20 MeV - 300 GeV energy range. The data collected since then allowed to multiply by a factor of 10 the number of Active Galactic Nuclei (AGN) detected in the GeV range. Gamma-rays observed in AGNs come from energetic precesses bringing into play very high energy charged particles. These particles are confined in a magnetized plasma jet rising in a region close to the supermassive black hole in the center of the host galaxy. This jet moves away with velocities as high as 0.9999 c, forming in many cases radio lobes on kilo-parsec or even mega-parsec scales. Among the AGNs, those whose jet inclination angle to the line of sight is small are called blazars. The combination of this small inclination angle with relativistic ejection speeds led to relativistic effects: apparent superluminal motions, amplification of the luminosity and modification of the time scales. Blazars are characterized by extreme variability at all wavelengths, on time scales from a few minutes to several months. A temporal and spectral study of the most luminous of those detected by the LAT, 3C 454.3, was done so as to constrain emission models. A new method for generating adaptive-binning light curves is also suggested in this thesis. It allows to extract the maximum of information from the LAT data whatever the flux state of the source. (author)

Gamma-ray and neutrino diffuse emissions of the Galaxy above the TeV

CERN Document Server

Gaggero, Daniele; Marinelli, Antonio; Urbano, Alfredo; Valli, Mauro

2016-01-01

As recently shown, Fermi-LAT measurements of the diffuse gamma-ray emission from the Galaxy favor the presence of a smooth softening in the primary cosmic-ray spectrum with increasing Galactocentric distance. This result can be interpreted in terms of a spatial-dependent rigidity scaling of the diffusion coefficient. The DRAGON code was used to build a model based on such feature. That scenario correctly reproduces the latest Fermi-LAT results as well as local cosmic-ray measurements from PAMELA, AMS-02 and CREAM. Here we show that the model, if extrapolated at larger energies, grasps both the gamma-ray flux measured by MILAGRO at 15 TeV and the H.E.S.S. data from the Galactic ridge, assuming that the cosmic-ray spectral hardening found by those experiments at about 250 GeV/n is present in the whole inner Galactic plane region. Moreover, we show as that model also predicts a neutrino emission which may account for a significant fraction, as well as for the correct spectral shape, of the astrophysical flux mea...

First Fermi-LAT Catalog of Sources above 10 GeV (1FHL)

Data.gov (United States)

National Aeronautics and Space Administration — This catalog of LAT sources above 10 GeV reports the locations, spectra, and variability properties of the 514 sources significantly detected in this range during...

Planck intermediate results XXVIII. Interstellar gas and dust in the Chamaeleon clouds as seen by Fermi LAT and Planck

DEFF Research Database (Denmark)

Ade, P. A. R.; Aghanim, N.; Aniano, G.

2015-01-01

the clouds. We have separated clouds at local, intermediate, and Galactic velocities in H i and 12CO line emission to model in parallel the γ-ray intensity recorded between 0.4 and 100 GeV; the dust optical depth at 353 GHz, τ353; the thermal radiance of the large grains; and an estimate of the dust...... extinction, AVQ, empirically corrected for the starlight intensity. The dust and gamma-models have been coupled to account for the DNM gas. The consistent γ-emissivity spectra recorded in the different phases confirm that the GeV-TeV cosmic rays probed by the LAT uniformly permeate all gas phases up...... in the gamma-versus dust calibration of XCO, but they confirm the factor of 2 difference found between the XCO estimates in nearby clouds and in the neighbouring spiral arms....

FERMI/LARGE AREA TELESCOPE DISCOVERY OF GAMMA-RAY EMISSION FROM A RELATIVISTIC JET IN THE NARROW-LINE QUASAR PMN J0948+0022

International Nuclear Information System (INIS)

Abdo, A. A.; Ackermann, M.; Ajello, M.; Bechtol, K.; Bloom, E. D.; Borgland, A. W.; Axelsson, M.; Battelino, M.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Brez, A.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Baughman, B. M.; Bonamente, E.; Brigida, M.; Caliandro, G. A.; Bruel, P.

2009-01-01

We report the discovery by the Large Area Telescope (LAT) onboard the Fermi Gamma-Ray Space Telescope of high-energy γ-ray emission from the peculiar quasar PMN J0948+0022 (z = 0.5846). The optical spectrum of this object exhibits rather narrow Hβ (FWHM(Hβ) ∼1500 km s -1 ), weak forbidden lines, and is therefore classified as a narrow-line type I quasar. This class of objects is thought to have relatively small black hole mass and to accrete at a high Eddington ratio. The radio loudness and variability of the compact radio core indicate the presence of a relativistic jet. Quasi-simultaneous radio/optical/X-ray and γ-ray observations are presented. Both radio and γ-ray emissions (observed over five months) are strongly variable. The simultaneous optical and X-ray data from Swift show a blue continuum attributed to the accretion disk and a hard X-ray spectrum attributed to the jet. The resulting broadband spectral energy distribution (SED) and, in particular, the γ-ray spectrum measured by Fermi are similar to those of more powerful Flat-Spectrum Radio Quasars (FSRQs). A comparison of the radio and γ-ray characteristics of PMN J0948+0022 with the other blazars detected by LAT shows that this source has a relatively low radio and γ-ray power with respect to other FSRQs. The physical parameters obtained from modeling the SED also fall at the low power end of the FSRQ parameter region discussed in Celotti and Ghisellini. We suggest that the similarity of the SED of PMN J0948+0022 to that of more massive and more powerful quasars can be understood in a scenario in which the SED properties depend on the Eddington ratio rather than on the absolute power.

A POPULATION OF X-RAY WEAK QUASARS: PHL 1811 ANALOGS AT HIGH REDSHIFT

International Nuclear Information System (INIS)

Wu Jianfeng; Brandt, W. N.; Schneider, Donald P.; Hall, Patrick B.; Gibson, Robert R.; Schmidt, Sarah J.; Richards, Gordon T.; Shemmer, Ohad; Just, Dennis W.

2011-01-01

We report the results from Chandra and XMM-Newton observations of a sample of 10 type 1 quasars selected to have unusual UV emission-line properties (weak and blueshifted high-ionization lines; strong UV Fe emission) similar to those of PHL 1811, a confirmed intrinsically X-ray weak quasar. These quasars were identified by the Sloan Digital Sky Survey at high redshift (z ∼ 2.2); eight are radio quiet while two are radio intermediate. All of the radio-quiet PHL 1811 analogs, without exception, are notably X-ray weak by a mean factor of ∼13. These sources lack broad absorption lines and have blue UV/optical continua, supporting the hypothesis that they are intrinsically X-ray weak like PHL 1811 itself. However, their average X-ray spectrum appears to be harder than those of typical quasars, which may indicate the presence of heavy intrinsic X-ray absorption. Our sample of radio-quiet PHL 1811 analogs supports a connection between an X-ray weak spectral energy distribution and PHL 1811-like UV emission lines; this connection provides an economical way to identify X-ray weak type 1 quasars. The fraction of radio-quiet PHL 1811 analogs in the radio-quiet quasar population is estimated to be ∼< 1.2%. We have investigated correlations between relative X-ray brightness and UV emission-line properties (e.g., C IV equivalent width and blueshift) for a sample combining our radio-quiet PHL 1811 analogs, PHL 1811 itself, and typical type 1 quasars. These correlation analyses suggest that PHL 1811 analogs may have extreme wind-dominated broad emission-line regions. Observationally, the radio-quiet PHL 1811 analogs appear to be a subset (∼30%) of radio-quiet weak-line quasars (WLQs). The existence of a subset of quasars in which high-ionization 'shielding gas' covers most of the broad emission-line region (BELR), but little more than the BELR, could potentially unify the PHL 1811 analogs and WLQs. The two radio-intermediate PHL 1811 analogs are X-ray bright. X

DEVELOPMENT OF THE MODEL OF GALACTIC INTERSTELLAR EMISSION FOR STANDARD POINT-SOURCE ANALYSIS OF FERMI LARGE AREA TELESCOPE DATA

Energy Technology Data Exchange (ETDEWEB)

Acero, F.; Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d’Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Ackermann, M.; Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Ajello, M. [Department of Physics and Astronomy, Clemson University, Kinard Lab of Physics, Clemson, SC 29634-0978 (United States); Albert, A.; Baldini, L.; Bloom, E. D.; Bottacini, E.; Caliandro, G. A.; Cameron, R. A. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bissaldi, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Bari, I-70126 Bari (Italy); Bonino, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, I-10125 Torino (Italy); Brandt, T. J.; Buson, S. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Bregeon, J. [Laboratoire Univers et Particules de Montpellier, Université Montpellier, CNRS/IN2P3, Montpellier (France); Bruel, P., E-mail: isabelle.grenier@cea.fr, E-mail: casandjian@cea.fr [Laboratoire Leprince-Ringuet, École polytechnique, CNRS/IN2P3, Palaiseau (France); and others

2016-04-01

Most of the celestial γ rays detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope originate from the interstellar medium when energetic cosmic rays interact with interstellar nucleons and photons. Conventional point-source and extended-source studies rely on the modeling of this diffuse emission for accurate characterization. Here, we describe the development of the Galactic Interstellar Emission Model (GIEM), which is the standard adopted by the LAT Collaboration and is publicly available. This model is based on a linear combination of maps for interstellar gas column density in Galactocentric annuli and for the inverse-Compton emission produced in the Galaxy. In the GIEM, we also include large-scale structures like Loop I and the Fermi bubbles. The measured gas emissivity spectra confirm that the cosmic-ray proton density decreases with Galactocentric distance beyond 5 kpc from the Galactic Center. The measurements also suggest a softening of the proton spectrum with Galactocentric distance. We observe that the Fermi bubbles have boundaries with a shape similar to a catenary at latitudes below 20° and we observe an enhanced emission toward their base extending in the north and south Galactic directions and located within ∼4° of the Galactic Center.

Leser–Trélat syndrome in malignant mesothelioma and pulmonary adenocarcinoma

DEFF Research Database (Denmark)

Jepsen, Rikke Karlin; Skov, Anne Guldhammer; Skov, Birgit Guldhammer

2014-01-01

The syndrome of Leser–Trélat (LT) is characterized by the sudden appearance of multiple seborrhoeic keratoses (SKs) in association with internal occult malignancy. Usually, the syndrome has been associated with adenocarcinoma, most frequently of the gastrointestinal tract and breast. The pathogen...

Implications of the cosmic ray electron spectrum and anisotropy measured with Fermi-LAT

Energy Technology Data Exchange (ETDEWEB)

Di Bernardo, Giuseppe [Gothenburg Univ. (Sweden). Dept. of Physics; Evoli, Carmelo [SISSA, Trieste (Italy); Gaggero, Daniele; Grasso, Dario [Pisa Univ. (Italy). Dipt. die Fisica; INFN, Pisa (Italy); Maccione, Luca [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Mazziotta, Mario Nicola [Istituto Nazionale di Fisica Nucleare, Bari (Italy)

2010-11-15

The Fermi Large Area Telescope (LAT) collaboration recently released the updated results of the measurement of the cosmic ray electron (CRE) spectrum and published its first constraints on the CRE anisotropy. With respect to the previous Fermi-LAT results, the CRE spectrum measurement was extended down from 20 to 7 GeV, thus providing a better lever arm to discriminate theoretical models. Here we show that the new data strengthen the evidence for the presence of two distinct electron and positron spectral components. Furthermore, we show that under such hypothesis most relevant CRE and positron data sets are remarkably well reproduced. Consistent fits of cosmic-ray nuclei and antiproton data, which are crucial to validate the adopted propagation setup(s) and to fix the solar modulation potential, are obtained for the Kraichnan and plain-diffusion propagation setups, while the Kolmogorov one is disfavored. We then confirm that nearby pulsars are viable source candidates of the required e{sup {+-}} extra-component. In that case, we show that the predicted CRE anisotropy is compatible with Fermi-LAT constraints and that a positive detection should be at hand of that observatory. Models assuming that only nearby supernova remnants contribute to the high energy tail of the observed CRE spectrum are in contrast with anisotropy limits. (orig.)

High-energy emission from bright gamma-ray bursts using Fermi

Energy Technology Data Exchange (ETDEWEB)

Bissaldi, Elisabetta

2010-05-25

Among the scientific objectives of one of the present NASA missions, the Fermi Gamma-ray Space Telescope (FGST), is the study of gamma-ray bursts (GRBs). Fermi's payload comprises two science instruments, the Large Area Telescope (LAT) and the Gamma-Ray Burst Monitor (GBM). GBM was designed to detect and localize bursts for the Fermi mission. By means of an array of 12 NaI(Tl) (8 keV to 1 MeV) and two BGO (0.2 to 40 MeV) scintillation detectors, GBM extends the energy range (20 MeV to > 300 GeV) of the LAT instrument into the traditional range of current GRB databases. The physical detector response of the GBM instrument to GRBs has been determined with the help of Monte Carlo simulations, which are supported and verified by on-ground individual detector calibration measurements. The GBM detectors have been calibrated from 10 keV to 17.5 MeV using various gamma sources, and the detector response has been derived by simulations over the entire energy range (8 keV to 40 MeV) using GEANT. The GBM instrument has been operating successfully in orbit since June 11, 2008. The total trigger count from the time GBM triggering was enabled in July 2008 through December 2009 is 655, and about 380 of these triggers were classified as GRBs. Moreover, GBM detected several bursts in common with the LAT. These amazing detections mainly fulfill the primary science goal of GBM, which is the joint analysis of spectra and time histories of GRBs observed by both Fermi instruments. For every trigger, GBM provides near-real time on-board burst locations to permit repointing of the spacecraft and to obtain LAT observations of delayed emission from bursts. GBM and LAT refined locations are rapidly disseminated to the scientific community, often permitting extensive multiwavelength follow-up observations by NASA's Swift mission or other space- based observatories, and by numerous ground-based telescopes, thus allowing redshift determinations. Calculations of LAT upper limits are

High-energy emission from bright gamma-ray bursts using Fermi

International Nuclear Information System (INIS)

Bissaldi, Elisabetta

2010-01-01

Among the scientific objectives of one of the present NASA missions, the Fermi Gamma-ray Space Telescope (FGST), is the study of gamma-ray bursts (GRBs). Fermi's payload comprises two science instruments, the Large Area Telescope (LAT) and the Gamma-Ray Burst Monitor (GBM). GBM was designed to detect and localize bursts for the Fermi mission. By means of an array of 12 NaI(Tl) (8 keV to 1 MeV) and two BGO (0.2 to 40 MeV) scintillation detectors, GBM extends the energy range (20 MeV to > 300 GeV) of the LAT instrument into the traditional range of current GRB databases. The physical detector response of the GBM instrument to GRBs has been determined with the help of Monte Carlo simulations, which are supported and verified by on-ground individual detector calibration measurements. The GBM detectors have been calibrated from 10 keV to 17.5 MeV using various gamma sources, and the detector response has been derived by simulations over the entire energy range (8 keV to 40 MeV) using GEANT. The GBM instrument has been operating successfully in orbit since June 11, 2008. The total trigger count from the time GBM triggering was enabled in July 2008 through December 2009 is 655, and about 380 of these triggers were classified as GRBs. Moreover, GBM detected several bursts in common with the LAT. These amazing detections mainly fulfill the primary science goal of GBM, which is the joint analysis of spectra and time histories of GRBs observed by both Fermi instruments. For every trigger, GBM provides near-real time on-board burst locations to permit repointing of the spacecraft and to obtain LAT observations of delayed emission from bursts. GBM and LAT refined locations are rapidly disseminated to the scientific community, often permitting extensive multiwavelength follow-up observations by NASA's Swift mission or other space- based observatories, and by numerous ground-based telescopes, thus allowing redshift determinations. Calculations of LAT upper limits are mainly based

3FHL: The Third Catalog of Hard Fermi -LAT Sources

Energy Technology Data Exchange (ETDEWEB)

Ajello, M. [Department of Physics and Astronomy, Clemson University, Kinard Lab of Physics, Clemson, SC 29634-0978 (United States); Atwood, W. B. [Santa Cruz Institute for Particle Physics, Department of Physics and Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Baldini, L. [Università di Pisa and Istituto Nazionale di Fisica Nucleare, Sezione di Pisa I-56127 Pisa (Italy); Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d’Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bissaldi, E. [Dipartimento di Fisica “M. Merlin” dell’Università e del Politecnico di Bari, I-70126 Bari (Italy); Blandford, R. D.; Bloom, E. D. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Bonino, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, I-10125 Torino (Italy); Bregeon, J. [Laboratoire Univers et Particules de Montpellier, Université Montpellier, CNRS/IN2P3, F-34095 Montpellier (France); Britto, R. J. [Department of Physics, University of the Free State, P.O. Box 339, Bloemfontein 9300 (South Africa); Bruel, P., E-mail: majello@slac.stanford.edu [Laboratoire Leprince-Ringuet, École polytechnique, CNRS/IN2P3, F-91128 Palaiseau (France); and others

2017-10-01

We present a catalog of sources detected above 10 GeV by the Fermi Large Area Telescope (LAT) in the first 7 years of data using the Pass 8 event-level analysis. This is the Third Catalog of Hard Fermi -LAT Sources (3FHL), containing 1556 objects characterized in the 10 GeV–2 TeV energy range. The sensitivity and angular resolution are improved by factors of 3 and 2 relative to the previous LAT catalog at the same energies (1FHL). The vast majority of detected sources (79%) are associated with extragalactic counterparts at other wavelengths, including 16 sources located at very high redshift ( z > 2). Of the sources, 8% have Galactic counterparts and 13% are unassociated (or associated with a source of unknown nature). The high-latitude sky and the Galactic plane are observed with a flux sensitivity of 4.4 to 9.5 × 10{sup −11} ph cm{sup −2} s{sup −1}, respectively (this is approximately 0.5% and 1% of the Crab Nebula flux above 10 GeV). The catalog includes 214 new γ -ray sources. The substantial increase in the number of photons (more than 4 times relative to 1FHL and 10 times to 2FHL) also allows us to measure significant spectral curvature for 32 sources and find flux variability for 163 of them. Furthermore, we estimate that for the same flux limit of 10{sup −12} erg cm{sup −2} s{sup −1}, the energy range above 10 GeV has twice as many sources as the range above 50 GeV, highlighting the importance, for future Cherenkov telescopes, of lowering the energy threshold as much as possible.

Is the 130 GeV line real? A search for systematics in the Fermi-LAT data

Energy Technology Data Exchange (ETDEWEB)

Finkbeiner, Douglas P.; Su, Meng [Institute for Theory and Computation, Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS-51, Cambridge, MA 02138 (United States); Weniger, Christoph, E-mail: dfinkbeiner@cfa.harvard.edu, E-mail: mengsu@cfa.harvard.edu, E-mail: weniger@mpp.mpg.de [Max-Planck-Institut für Physik, Föhringer Ring 6, 80805 München (Germany)

2013-01-01

Our recent claims of a Galactic center feature in Fermi-LAT data at approximately 130 GeV have motivated a large number of papers proposing explanations ranging from dark matter annihilation to monoenergetic pulsar winds. Because of the importance of such interpretations for physics and astrophysics, a discovery will require not only additional data, but a thorough investigation of possible LAT systematics. While we do not have access to the details of each event reconstruction, we do have information about each event from the public event lists and spacecraft parameter files. These data allow us to search for suspicious trends that could indicate a spurious signal. We consider several hypotheses that might make an instrumental artifact more apparent at the Galactic center, and find them implausible. We also search for an instrumental signature in the Earth limb photons, which provide a smooth reference spectrum for null tests. We find no significant 130 GeV feature in the Earth limb sample. However, we do find a marginally significant 130 GeV feature in Earth limb photons with a limited range of detector incidence angles. This raises concerns about the 130 GeV Galactic center feature, even though we can think of no plausible model of instrumental behavior that connects the two. A modest amount of additional limb data would tell us if the limb feature is a statistical fluke. If the limb feature persists, it would raise doubts about the Pass 7 processing of E > 100 GeV events. At present we find no instrumental systematics that could plausibly explain the excess Galactic center emission at 130 GeV.

Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation

Science.gov (United States)

BenMohamed, Lbachir; Osorio, Nelson; Srivastava, Ruchi; Khan, Arif A.; Simpson, Jennifer L.; Wechsler, Steven L.

2015-01-01

Blinding ocular herpetic disease in humans is due to herpes simplex virus type 1 (HSV-1) reactivations from latency, rather than to primary acute infection. The cellular and molecular mechanisms that control the HSV-1 latency-reactivation cycle remain to be fully elucidated. The aim of this study was to determine if reactivation of the HSV-1 latency associated transcript (LAT) deletion mutant (dLAT2903) was impaired in this model, as it is in the rabbit model of induced and spontaneous reactivation and in the explant TG induced reactivation model in mice. The eyes of mice latently infected with wild type HSV-1 strain McKrae (LAT(+) virus) or dLAT2903 (LAT(−) virus) were irradiated with UV-B and reactivation was determined. We found that compared to LAT(−) virus, LAT(+) virus reactivated at a higher rate as determined by shedding of virus in tears on days 3 to 7 after UV-B treatment. Thus, the UV-B induced reactivation model of HSV-1 appears to be a useful small animal model for studying the mechanisms involved in how LAT enhances the HSV-1 reactivation phenotype. The utility of the model for investigating the immune evasion mechanisms regulating the HSV-1 latency/reactivation cycle and for testing the protective efficacy of candidate therapeutic vaccines and drugs are discussed. PMID:26002839

High-energy Emission from Nonrelativistic Radiative Shocks: Application to Gamma-Ray Novae

Science.gov (United States)

Vurm, Indrek; Metzger, Brian D.

2018-01-01

The observation of GeV gamma-rays from novae by Fermi/LAT demonstrates that the nonrelativistic radiative shocks in these systems can accelerate particles to energies of at least ∼10 GeV. The low-energy extension of the same nonthermal particle distribution inevitably gives rise to emission in the hard X-ray band. Above ≳ 10 {keV}, this radiation can escape the system without significant absorption/attenuation, and can potentially be detected by NuSTAR. We present theoretical models for hard X-ray and gamma-ray emission from radiative shocks in both leptonic and hadronic scenarios, accounting for the rapid evolution of the downstream properties due to the fast cooling of thermal plasma. We find that due to strong Coulomb losses, only a fraction of {10}-4{--}{10}-3 of the gamma-ray luminosity is radiated in the NuSTAR band; nevertheless, this emission could be detectable simultaneously with the LAT emission in bright gamma-ray novae with a ∼50 ks exposure. The spectral slope in hard X-rays is α ≈ 0 for typical nova parameters, thus serving as a testable prediction of the model. Our work demonstrates how combined hard X-ray and gamma-ray observations can be used to constrain properties of the nova outflow (velocity, density, and mass outflow rate) and particle acceleration at the shock. A very low X-ray to gamma-ray luminosity ratio ({L}{{X}}/{L}γ ≲ 5× {10}-4) would disfavor leptonic models for the gamma-ray emission. Our model can also be applied to other astrophysical environments with radiative shocks, including SNe IIn and colliding winds in massive star binaries.

Fermi-LAT: 4+ Years Out and Just Getting Started!

CERN Multimedia

CERN. Geneva

2012-01-01

The Fermi mission was launched into low Earth orbit in June, 2008. Now in its 5th year of data taking, the primary instrument, the Large Area Telescope (LAT), is now beginning to have a sufficient exposure to probe such fundamental issues as signals from Dark Matter. The achievements of the mission so far will be reviewed and a look towards what the next years could reveal will be presented.

miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1

Energy Technology Data Exchange (ETDEWEB)

Liu, Shikai; Song, Lili, E-mail: commasll@163.com; Zhang, Liang; Zeng, Saitian; Gao, Fangyuan

2015-04-17

Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1.

miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1

International Nuclear Information System (INIS)

Liu, Shikai; Song, Lili; Zhang, Liang; Zeng, Saitian; Gao, Fangyuan

2015-01-01

Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1

Bounds on dark matter interpretation of Fermi-LAT GeV excess

Directory of Open Access Journals (Sweden)

Kyoungchul Kong

2014-11-01

Full Text Available Annihilation of light dark matter of mDM≈(10–40 GeV into the Standard Model fermions has been suggested as a possible origin of the gamma-ray excess at GeV energies in the Fermi-LAT data. In this paper, we examine possible model-independent signatures of such dark matter models in other experiments such as AMS-02, colliders, and cosmic microwave background (CMB measurements. We point out that first generation of fermion final states is disfavored by the existing experimental data. Currently AMS-02 positron measurements provide stringent bounds on cross sections of dark matter annihilation into leptonic final states, and e+e− final state is in severe tension with this constraint, if not ruled out. The e+e− channel will be complementarily verified in an early stage of ILC and future CMB measurements. Light quark final states (qq¯ are relatively strongly constrained by the LHC and dark matter direct detection experiments even though these bounds are model-dependent. Dark matter signals from annihilations into qq¯ channels would be constrained by AMS-02 antiproton data which will be released in very near future. In optimistic case, diffuse radio emission from nearby galaxy (clusters and the galactic center might provide another hint or limit on dark matter annihilation.

Multi-wavelength emission from 3C 66A: clues to its redshift and gamma-ray emission location

International Nuclear Information System (INIS)

Yan Da-Hai; Fan Zhong-Hui; Zhou Yao; Dai Ben-Zhong

2013-01-01

The quasi-simultaneous multi-wavelength emission of TeV blazar 3C 66A is studied by using a one-zone multi-component leptonic jet model. It is found that the quasi-simultaneous spectral energy distribution of 3C 66A can be well reproduced; in particular, the first three months of its average Fermi-LAT spectrum can be well reproduced by the synchrotron self-Compton component plus external Compton component of the broad line region (BLR). Clues to its redshift and gamma-ray emission location are obtained. The results indicate the following. (i) On the redshift: The theoretical intrinsic TeV spectra can be predicted by extrapolating the reproduced GeV spectra. Through comparing these extrapolated TeV spectra with the corrected observed TeV spectra from extragalactic background light, it is suggested that the redshift of 3C 66A could be between 0.1 and 0.3, with the most likely value being ∼ 0.2. (ii) On the gamma-ray emission location: To well reproduce the GeV emission of 3C 66A under different assumptions on the BLR, the gamma-ray emission region is always required to be beyond the inner zone of the BLR. The BLR absorption effect on gamma-ray emission confirms this point.

Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo.

Science.gov (United States)

Kalia, Neena; Auger, Jocelyn M; Atkinson, Ben; Watson, Steve P

2008-05-01

The role of collagen receptor complex GPVI-FcR gamma-chain, PLCgamma2 and LAT in laser-induced thrombosis is unclear. Controversy surrounds whether collagen is exposed in this model or whether thrombosis is dependent on thrombin. This study hypothesized that collagen exposure plays a critical role in thrombus formation in this model, which was tested by investigating contributions of FcR gamma-chain, LAT, PLCgamma2 and thrombin. Thrombi were monitored using intravital microscopy in anesthetized wild-type and FcR gamma-chain, LAT and PLCgamma2 knockout mice. Hirudin (thrombin inhibitor) was administered to wild-type and FcR gamma-chain knockout mice. Significantly reduced thrombus formation was observed in FcR gamma-chain and PLCgamma2 knockouts with a greater decrease observed in LAT knockouts. Dramatic reduction was observed in wild-types treated with hirudin, with abolished thrombus formation only observed in FcR gamma-chain knockouts treated with hirudin. GPVI-FcR gamma-chain, LAT and PLCgamma2 are essential for thrombus generation and stability in this laser-induced model of injury. More importantly, a greater role for LAT was identified, which may reflect a role for it downstream of a second matrix protein receptor. However, inhibition of platelet activation by matrix proteins and thrombin generation are both required to maximally prevent thrombus formation.

Anisotropies in the diffuse gamma-ray background from dark matter with Fermi LAT: a closer look

DEFF Research Database (Denmark)

Cuoco, Alessandro; Sellerholm, A.; Conrad, J.

2011-01-01

We perform a detailed study of the sensitivity to the anisotropies related to dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) as measured by the Fermi Large Area Telescope (Fermi LAT). For the first time, we take into account the effects of the Galactic foregrounds...... of the detector are taken into account by convolving the model maps with the Fermi LAT instrumental response. We then use the angular power spectrum to characterize the anisotropy properties of the simulated data and to study the sensitivity to DM. We consider DM anisotropies of extragalactic origin...

The effect of acetylcholine, LatA and FAA on phloem assimilates translocation of Raphanus sativus L

International Nuclear Information System (INIS)

Yang Chongjun; Zhang Ping

2005-01-01

The petiole phloem of Raphanus sativus L. is treated with the medicaments of acetylcholine (Ach, the expansionist material of protoplasm), latrunculin A (LatA, the dissolubility of microfilament) and FAA (the regularization of phloem). The effects of treatments are measured by the accumulated content of dissoluble sugar and starch in the leaves, and 14 C-labelled assimilates. The regulating role of three medicaments on the translocation of assimilates in the phloem of Raphanus sativus L are investigated. The results indicate that low Ach improves assimilates translocation while LatA and FAA inhibit it in petiole phloem of Raphanus sativus L.. (authors)

An image-based search for pulsars among Fermi unassociated LAT sources

Science.gov (United States)

Frail, D. A.; Ray, P. S.; Mooley, K. P.; Hancock, P.; Burnett, T. H.; Jagannathan, P.; Ferrara, E. C.; Intema, H. T.; de Gasperin, F.; Demorest, P. B.; Stovall, K.; McKinnon, M. M.

2018-03-01

We describe an image-based method that uses two radio criteria, compactness, and spectral index, to identify promising pulsar candidates among Fermi Large Area Telescope (LAT) unassociated sources. These criteria are applied to those radio sources from the Giant Metrewave Radio Telescope all-sky survey at 150 MHz (TGSS ADR1) found within the error ellipses of unassociated sources from the 3FGL catalogue and a preliminary source list based on 7 yr of LAT data. After follow-up interferometric observations to identify extended or variable sources, a list of 16 compact, steep-spectrum candidates is generated. An ongoing search for pulsations in these candidates, in gamma rays and radio, has found 6 ms pulsars and one normal pulsar. A comparison of this method with existing selection criteria based on gamma-ray spectral and variability properties suggests that the pulsar discovery space using Fermi may be larger than previously thought. Radio imaging is a hitherto underutilized source selection method that can be used, as with other multiwavelength techniques, in the search for Fermi pulsars.

Hunting for Intrinsically X-ray Weak Quasars: The Case of PHL 1811 Analogs

Science.gov (United States)

Brandt, William

2009-09-01

A central dogma of X-ray astronomy is that luminous X-ray emission is a universal property of efficiently accreting supermassive black holes. One interesting challenge to this idea has come from the quasar PHL 1811 which appears to be intrinsically X-ray weak and also has distinctive emission-line properties. We propose to observe a sample of eight SDSS quasars, selected to have similar UV emission-line properties to that of PHL 1811, to test if they are also X-ray weak. Our analyses of the currently available X-ray data appear to support this hypothesis but do not provide a proper test. Our results will have implications for the nature of accretion-disk coronae, emission-line formation, and AGN selection.

WEAK AND COMPACT RADIO EMISSION IN EARLY HIGH-MASS STAR-FORMING REGIONS. I. VLA OBSERVATIONS

Energy Technology Data Exchange (ETDEWEB)

Rosero, V.; Hofner, P. [Physics Department, New Mexico Tech, 801 Leroy Pl., Socorro, NM 87801 (United States); Claussen, M. [National Radio Astronomy Observatory, 1003 Lopezville Rd., Socorro, NM 87801 (United States); Kurtz, S.; Carrasco-González, C.; Rodríguez, L. F.; Loinard, L. [Instituto de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, Morelia 58090, México (Mexico); Cesaroni, R. [INAF, Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy); Araya, E. D. [Physics Department, Western Illinois University, 1 University Circle, Macomb, IL 61455 (United States); Menten, K. M.; Wyrowski, F. [Max-Planck-Institute für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Ellingsen, S. P. [School of Physical Sciences, University of Tasmania, Private Bag 37, Hobart, Tasmania 7001 (Australia)

2016-12-01

We present a high-sensitivity radio continuum survey at 6 and 1.3 cm using the Karl G. Jansky Very Large Array toward a sample of 58 high-mass star-forming regions. Our sample was chosen from dust clumps within infrared dark clouds with and without IR sources (CMC–IRs and CMCs, respectively), and hot molecular cores (HMCs), with no previous, or relatively weak radio continuum detection at the 1 mJy level. Due to the improvement in the continuum sensitivity of the Very Large Array, this survey achieved map rms levels of ∼3–10  μ Jy beam{sup −1} at sub-arcsecond angular resolution. We extracted 70 continuum sources associated with 1.2 mm dust clumps. Most sources are weak, compact, and prime candidates for high-mass protostars. Detection rates of radio sources associated with the millimeter dust clumps for CMCs, CMC–IRs, and HMCs are 6%, 53%, and 100%, respectively. This result is consistent with increasing high-mass star formation activity from CMCs to HMCs. The radio sources located within HMCs and CMC–IRs occur close to the dust clump centers, with a median offset from it of 12,000 au and 4000 au, respectively. We calculated 5–25 GHz spectral indices using power-law fits and obtained a median value of 0.5 (i.e., flux increasing with frequency), suggestive of thermal emission from ionized jets. In this paper we describe the sample, observations, and detections. The analysis and discussion will be presented in Paper II.

Algunas reflexiones acerca de la enseñanza del latín

Directory of Open Access Journals (Sweden)

María Purificación Estebañez

1995-06-01

Full Text Available Las reflexiones y sugerencias que en esta Comunicación desea mosofrecer son, sin duda alguna, el fruto de una larga experiencia en la enseñanza de los Cursos de Latín en la Pontificia UniversidadCatólica del Perú.

Emission channeling lattice location experiments with short-lived isotopes

CERN Multimedia

Wahl, U; Ronning, C R

2007-01-01

Emission channeling with position-sensitive detectors is a well-established technique at ISOLDE for studying the lattice location of radioactive impurities implanted into single crystals. In the case of electron emitting isotopes, however, due to count rate and noise-related limitations of the detection systems, the technique was restricted to isotopes with half lives above 6 h and electron energies above 40 keV. Recently, major technical developments have been realized and new equipment has been acquired which has allowed these limitations to be overcome and made feasible electron emission channeling experiments with short-lived isotopes and at low electron energies.\\\\ As first application, making use of two new on-line emission channeling setups at ISOLDE, we propose to investigate the lattice location of the transition metals Ni (2.5 h) and Co (1.6 h) in semiconductors, in particular in ZnO and GaN, by means of on-line $\\beta^{-}$-emission channeling experiments. In addition, we would like to study the lat...

The Spectrum of Isotropic Diffuse Gamma-Ray Emission Between 100 Mev and 820 Gev

Science.gov (United States)

Ackermann, M.; Ajello, M.; Albert, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Brandt, T. J.; Hays, E.;

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.

Science.gov (United States)

Philippe, Chloé; Pinson, Benoît; Dompierre, Jim; Pantesco, Véronique; Viollet, Benoît; Daignan-Fornier, Bertrand; Moenner, Michel

2018-06-01

AICAR (Acadesine) is a pharmacological precursor of purine nucleotide biosynthesis with anti-tumoral properties. Although recognized as an AMP mimetic activator of the protein kinase AMPK, the AICAR monophosphate derivative ZMP was also shown to mediate AMPK-independent effects. In order to unveil these AMPK-independent functions, we performed a transcriptomic analysis in AMPKα1/α2 double knockout murine embryonic cells. Kinetic analysis of the cellular response to AICAR revealed the up-regulation of the large tumor suppressor kinases (Lats) 1 and 2 transcripts, followed by the repression of numerous genes downstream of the transcriptional regulators Yap1 and Taz. This transcriptional signature, together with the observation of increased levels in phosphorylation of Lats1 and Yap1 proteins, suggested that the Hippo signaling pathway was activated by AICAR. This effect was observed in both fibroblasts and epithelial cells. Knockdown of Lats1/2 prevented the cytoplasmic delocalization of Yap1/Taz proteins in response to AICAR and conferred a higher resistance to the drug. These results indicate that activation of the most downstream steps of the Hippo cascade participates to the antiproliferative effects of AICAR. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Parsec-Scale Properties of Gamma-Ray Bright Blazars

Science.gov (United States)

Linford, Justin Dee

The parsec-scale radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been investigated using observations with the Very Long Baseline Array (VLBA). Comparisons between LAT and non-LAT detected samples were made using both archival and contemporaneous data. In total, 244 sources were used in the LAT-detected sample. This very large, radio flux-limited sample of active galactic nuclei (AGN) provides insights into the mechanism that produces strong gamma-ray emission. It has been found that LAT-detected BL Lac objects are very similar to the non-LAT BL Lac objects in most properties, although LAT BL Lac objects may have longer jets. The LAT flat spectrum radio quasars (FSRQs) are significantly different from non-LAT FSRQs and are likely extreme members of the FSRQ population. Archival radio data indicated that there was no significant correlation between radio flux density and gamma-ray flux, especially at lower flux levels. However, contemporaneous observations showed a strong correlation. Most of the differences between the LAT and non-LAT populations are related to the cores of the sources, indicating that the gamma-ray emission may originate near the base of the jets (i.e., within a few pc of the central engine). There is some indication that LAT-detected sources may have larger jet opening angles than the non-LAT sources. Strong core polarization is significantly more common among the LAT sources, suggesting that gamma-ray emission is related to strong, uniform magnetic fields at the base of the jets of the blazars. Observations of sources in two epochs indicate that core fractional polarization was higher when the objects were detected by the LAT. The low-synchrotron peaked (LSP) BL Lac object sample shows indications of contamination by FSRQs which happen to have undetectable emission lines. There is evidence that the LSP BL Lac objects are more strongly beamed than the rest of the BL Lac

V819 TAU: A RARE WEAK-LINED T TAURI STAR WITH A WEAK INFRARED EXCESS

International Nuclear Information System (INIS)

Furlan, E.; Forrest, W. J.; Manoj, P.; Kim, K. H.; Watson, Dan M.; Sargent, B. A.

2009-01-01

We use Spitzer data to infer that the small infrared excess of V819 Tau, a weak-lined T Tauri star in Taurus, is real and not attributable to a 'companion' 10'' to the south. We do not confirm the mid-infrared excess in HBC 427 and V410 X-ray 3, which are also non-accreting T Tauri stars in the same region; instead, for the former object, the excess arises from a red companion 9'' to the east. A single-temperature blackbody fit to the continuum excess of V819 Tau implies a dust temperature of 143 K; however, a better fit is achieved when the weak 10 and 20 μm silicate emission features are also included. We infer a disk of sub-μm silicate grains between about 1 AU and several 100 AU with a constant surface density distribution. The mid-infrared excess of V819 Tau can be successfully modeled with dust composed mostly of small amorphous olivine grains at a temperature of 85 K, and most of the excess emission is optically thin. The disk could still be primordial, but gas-poor and therefore short-lived, or already at the debris disk stage, which would make it one of the youngest debris disk systems known.

The first fermi-lat catalog of sources above 10 GeV

Energy Technology Data Exchange (ETDEWEB)

Ackermann, M.; Ajello, M.; Allafort, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Belfiore, A.; Bellazzini, R.; Bernieri, E.; Bissaldi, E.; Bloom, E. D.; Bonamente, E.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Burnett, T. H.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Campana, R.; Caraveo, P. A.; Casandjian, J. M.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chaves, R. C. G.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Chiaro, G.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Cominsky, L. R.; Conrad, J.; Cutini, S.; D' Ammando, F.; de Angelis, A.; de Palma, F.; Dermer, C. D.; Desiante, R.; Digel, S. W.; Di Venere, L.; Drell, P. S.; Drlica-Wagner, A.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Focke, W. B.; Fortin, P.; Franckowiak, A.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Germani, S.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Godfrey, G.; Gomez-Vargas, G. A.; Grenier, I. A.; Guiriec, S.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Hewitt, J.; Hill, A. B.; Horan, D.; Hughes, R. E.; Jogler, T.; Jóhannesson, G.; Johnson, A. S.; Johnson, T. J.; Johnson, W. N.; Kamae, T.; Kataoka, J.; Kawano, T.; Knödlseder, J.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Lemoine-Goumard, M.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Massaro, E.; Mayer, M.; Mazziotta, M. N.; McEnery, J. E.; Mehault, J.; Michelson, P. F.; Mizuno, T.; Moiseev, A. A.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nemmen, R.; Nuss, E.; Ohsugi, T.; Okumura, A.; Orienti, M.; Ormes, J. F.; Paneque, D.; Perkins, J. S.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Rainò, S.; Razzano, M.; Reimer, A.; Reimer, O.; Reposeur, T.; Ritz, S.; Romani, R. W.; Roth, M.; Saz Parkinson, P. M.; Schulz, A.; Sgrò, C.; Siskind, E. J.; Smith, D. A.; Spandre, G.; Spinelli, P.; Stawarz, Łukasz; Strong, A. W.; Suson, D. J.; Takahashi, H.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Uchiyama, Y.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Werner, M.; Winer, B. L.; Wood, K. S.; Wood, M.

2013-11-14

We present a catalog of gamma-ray sources at energies above 10 GeV based on data from the Large Area Telescope (LAT) accumulated during the first three years of the Fermi Gamma-ray Space Telescope mission. The first Fermi-LAT catalog of >10GeV sources (1FHL) has 514 sources. For each source we present location, spectrum, a measure of variability, and associations with cataloged sources at other wavelengths. We found that 449 (87%) could be associated with known sources, of which 393 (76% of the 1FHL sources) are active galactic nuclei. Of the 27 sources associated with known pulsars, we find 20 (12) to have significant pulsations in the range >10GeV (>25GeV). In this work we also report that, at energies above 10 GeV, unresolved sources account for 27+/-8 % of the isotropic gamma-ray background, while the unresolved Galactic population contributes only at the few percent level to the Galactic diffuse background. We also highlight the subset of the 1FHL sources that are best candidates for detection at energies above 50-100 GeV with current and future ground-based gamma-ray observatories.

CONSTRAINTS ON THE EMISSION GEOMETRIES AND SPIN EVOLUTION OF GAMMA-RAY MILLISECOND PULSARS

Energy Technology Data Exchange (ETDEWEB)

Johnson, T. J. [National Research Council Research Associate, National Academy of Sciences, Washington, DC 20001 (United States); Venter, C. [Centre for Space Research, North-West University, Potchefstroom Campus, Private Bag X6001, 2520 Potchefstroom (South Africa); Harding, A. K.; Çelik, Ö.; Ferrara, E. C. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Guillemot, L. [Laboratoire de Physique et Chimie de l' Environnement, LPCE UMR 6115 CNRS, F-45071 Orléans Cedex 02 (France); Smith, D. A.; Hou, X. [Centre d' Études Nucléaires de Bordeaux Gradignan, IN2P3/CNRS, Université Bordeaux 1, BP120, F-33175 Gradignan Cedex (France); Kramer, M. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, 53121 Bonn (Germany); Den Hartog, P. R. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Lande, J. [Twitter Inc., 1355 Market Street 900, San Francisco, CA 94103 (United States); Ray, P. S., E-mail: tyrel.j.johnson@gmail.com, E-mail: Christo.Venter@nwu.ac.za, E-mail: ahardingx@yahoo.com [Space Science Division, Naval Research Laboratory, Washington, DC 20375-5352 (United States)

2014-07-01

Millisecond pulsars (MSPs) are a growing class of gamma-ray emitters. Pulsed gamma-ray signals have been detected from more than 40 MSPs with the Fermi Large Area Telescope (LAT). The wider radio beams and more compact magnetospheres of MSPs enable studies of emission geometries over a broader range of phase space than non-recycled radio-loud gamma-ray pulsars. We have modeled the gamma-ray light curves of 40 LAT-detected MSPs using geometric emission models assuming a vacuum retarded-dipole magnetic field. We modeled the radio profiles using a single-altitude hollow-cone beam, with a core component when indicated by polarimetry; however, for MSPs with gamma-ray and radio light curve peaks occurring at nearly the same rotational phase, we assume that the radio emission is co-located with the gamma rays and caustic in nature. The best-fit parameters and confidence intervals are determined using a maximum likelihood technique. We divide the light curves into three model classes, with gamma-ray peaks trailing (Class I), aligned (Class II), or leading (Class III) the radio peaks. Outer gap and slot gap (two-pole caustic) models best fit roughly equal numbers of Class I and II, while Class III are exclusively fit with pair-starved polar cap models. Distinguishing between the model classes based on typical derived parameters is difficult. We explore the evolution of the magnetic inclination angle with period and spin-down power, finding possible correlations. While the presence of significant off-peak emission can often be used as a discriminator between outer gap and slot gap models, a hybrid model may be needed.

CONSTRAINTS ON THE EMISSION GEOMETRIES AND SPIN EVOLUTION OF GAMMA-RAY MILLISECOND PULSARS

International Nuclear Information System (INIS)

Johnson, T. J.; Venter, C.; Harding, A. K.; Çelik, Ö.; Ferrara, E. C.; Guillemot, L.; Smith, D. A.; Hou, X.; Kramer, M.; Den Hartog, P. R.; Lande, J.; Ray, P. S.

2014-01-01

Millisecond pulsars (MSPs) are a growing class of gamma-ray emitters. Pulsed gamma-ray signals have been detected from more than 40 MSPs with the Fermi Large Area Telescope (LAT). The wider radio beams and more compact magnetospheres of MSPs enable studies of emission geometries over a broader range of phase space than non-recycled radio-loud gamma-ray pulsars. We have modeled the gamma-ray light curves of 40 LAT-detected MSPs using geometric emission models assuming a vacuum retarded-dipole magnetic field. We modeled the radio profiles using a single-altitude hollow-cone beam, with a core component when indicated by polarimetry; however, for MSPs with gamma-ray and radio light curve peaks occurring at nearly the same rotational phase, we assume that the radio emission is co-located with the gamma rays and caustic in nature. The best-fit parameters and confidence intervals are determined using a maximum likelihood technique. We divide the light curves into three model classes, with gamma-ray peaks trailing (Class I), aligned (Class II), or leading (Class III) the radio peaks. Outer gap and slot gap (two-pole caustic) models best fit roughly equal numbers of Class I and II, while Class III are exclusively fit with pair-starved polar cap models. Distinguishing between the model classes based on typical derived parameters is difficult. We explore the evolution of the magnetic inclination angle with period and spin-down power, finding possible correlations. While the presence of significant off-peak emission can often be used as a discriminator between outer gap and slot gap models, a hybrid model may be needed

Broad band simulation of Gamma Ray Bursts (GRB) prompt emission in presence of an external magnetic field

Science.gov (United States)

Ziaeepour, Houri; Gardner, Brian

2011-12-01

The origin of prompt emission in GRBs is not yet well understood. The simplest and most popular model is Synchrotron Self-Compton (SSC) emission produced by internal shocks inside an ultra-relativistic jet. However, recent observations of a delayed high energy component by the Fermi-LAT instrument have encouraged alternative models. Here we use a recently developed formulation of relativistic shocks for GRBs to simulate light curves and spectra of synchrotron and self-Compton emissions in the framework of internal shock model. This model takes into account the evolution of quantities such as densities of colliding shells, and fraction of kinetic energy transferred to electrons and to induced magnetic field. We also extend this formulation by considering the presence of a precessing external magnetic field. These simulations are very realistic and present significant improvement with respect to previous phenomenological GRB simulations. They reproduce light curves of separate peaks of real GRBs and variety of spectral slopes at E > Epeak observed by the Fermi-LAT instrument. The high energy emission can be explained by synchrotron emission and a subdominant contribution from inverse Compton. We also suggest an explanation for extended tail emission and relate it to the screening of the magnetic field and/or trapping of accelerated electrons in the electromagnetic energy structure of the plasma in the shock front. Spectral slopes of simulated bursts at E external magnetic field, we show that due to the fast variation of other quantities, its signature in the Power Distribution Spectrum (PDS) is significantly suppressed and only when the duration of the burst is few times longer than the oscillation period it can be detected, otherwise either it is confused with the Poisson noise or with intrinsic variations of the emission. Therefore, low significant oscillations observed in the PDS of GRB 090709a are most probably due to a precessing magnetic field.

Fermi-LAT kills dark matter interpretations of AMS-02 data. Or not?

Energy Technology Data Exchange (ETDEWEB)

Belotsky, Konstantin; Budaev, Ruslan; Kirillov, Alexander; Laletin, Maxim, E-mail: k-belotsky@yandex.ru, E-mail: buday48@mail.ru, E-mail: AAKirillov@mephi.ru, E-mail: maxim.laletin@ulg.ac.be [Department of Elementary Particle Physics, National Research Nuclear University MEPhI, 115409 Kashirskoe shosse 31, Moscow (Russian Federation)

2017-01-01

A number of papers attempt to explain the positron anomaly in cosmic rays, observed by PAMELA and AMS-02, in terms of dark matter (DM) decays or annihilations. However, the recent progress in cosmic gamma-ray studies challenges these attempts. Indeed, as we show, any rational DM model explaining the positron anomaly abundantly produces final state radiation and Inverse Compton gamma rays, which inevitably leads to a contradiction with Fermi-LAT isotropic diffuse gamma-ray background measurements. Furthermore, the Fermi-LAT observation of Milky Way dwarf satellites, supposed to be rich in DM, revealed no significant signal in gamma rays. We propose a generic approach in which the major contribution to cosmic rays comes from the dark matter disc and prove that the tension between the DM origin of the positron anomaly and the cosmic gamma-ray observations can be relieved. We consider both a simple model, in which DM decay/annihilate into charged leptons, and a model-independent minimal case of particle production, and we estimate the optimal thickness of DM disk. Possible mechanisms of formation and its properties are briefly discussed.

Legal assessment tool (LAT): an interactive tool to address privacy and data protection issues for data sharing.

Science.gov (United States)

Kuchinke, Wolfgang; Krauth, Christian; Bergmann, René; Karakoyun, Töresin; Woollard, Astrid; Schluender, Irene; Braasch, Benjamin; Eckert, Martin; Ohmann, Christian

2016-07-07

In an unprecedented rate data in the life sciences is generated and stored in many different databases. An ever increasing part of this data is human health data and therefore falls under data protected by legal regulations. As part of the BioMedBridges project, which created infrastructures that connect more than 10 ESFRI research infrastructures (RI), the legal and ethical prerequisites of data sharing were examined employing a novel and pragmatic approach. We employed concepts from computer science to create legal requirement clusters that enable legal interoperability between databases for the areas of data protection, data security, Intellectual Property (IP) and security of biosample data. We analysed and extracted access rules and constraints from all data providers (databases) involved in the building of data bridges covering many of Europe's most important databases. These requirement clusters were applied to five usage scenarios representing the data flow in different data bridges: Image bridge, Phenotype data bridge, Personalised medicine data bridge, Structural data bridge, and Biosample data bridge. A matrix was built to relate the important concepts from data protection regulations (e.g. pseudonymisation, identifyability, access control, consent management) with the results of the requirement clusters. An interactive user interface for querying the matrix for requirements necessary for compliant data sharing was created. To guide researchers without the need for legal expert knowledge through legal requirements, an interactive tool, the Legal Assessment Tool (LAT), was developed. LAT provides researchers interactively with a selection process to characterise the involved types of data and databases and provides suitable requirements and recommendations for concrete data access and sharing situations. The results provided by LAT are based on an analysis of the data access and sharing conditions for different kinds of data of major databases in Europe

FLaapLUC: A pipeline for the generation of prompt alerts on transient Fermi-LAT γ-ray sources

Science.gov (United States)

Lenain, J.-P.

2018-01-01

The large majority of high energy sources detected with Fermi-LAT are blazars, which are known to be very variable sources. High cadence long-term monitoring simultaneously at different wavelengths being prohibitive, the study of their transient activities can help shedding light on our understanding of these objects. The early detection of such potentially fast transient events is the key for triggering follow-up observations at other wavelengths. A Python tool, FLaapLUC, built on top of the Science Tools provided by the Fermi Science Support Center and the Fermi-LAT collaboration, has been developed using a simple aperture photometry approach. This tool can effectively detect relative flux variations in a set of predefined sources and alert potential users. Such alerts can then be used to trigger target of opportunity observations with other facilities. It is shown that FLaapLUC is an efficient tool to reveal transient events in Fermi-LAT data, providing quick results which can be used to promptly organise follow-up observations. Results from this simple aperture photometry method are also compared to full likelihood analyses. The FLaapLUC package is made available on GitHub and is open to contributions by the community.

WEAK LINE QUASARS AT HIGH REDSHIFT: EXTREMELY HIGH ACCRETION RATES OR ANEMIC BROAD-LINE REGIONS?

International Nuclear Information System (INIS)

Shemmer, Ohad; Trakhtenbrot, Benny; Netzer, Hagai; Anderson, Scott F.; Brandt, W. N.; Schneider, Donald P.; Diamond-Stanic, Aleksandar M.; Fan Xiaohui; Lira, Paulina; Plotkin, Richard M.; Richards, Gordon T.; Strauss, Michael A.

2010-01-01

We present Gemini-North K-band spectra of two representative members of the class of high-redshift quasars with exceptionally weak rest-frame ultraviolet emission lines (WLQs), SDSS J114153.34+021924.3 at z = 3.55 and SDSS J123743.08+630144.9 at z = 3.49. In both sources, we detect an unusually weak broad Hβ line and place tight upper limits on the strengths of their [O III] lines. Virial, Hβ-based black hole mass determinations indicate normalized accretion rates of L/L Edd =0.4 for these sources, which is well within the range observed for typical quasars with similar luminosities and redshifts. We also present high-quality XMM-Newton imaging spectroscopy of SDSS J114153.34+021924.3 and find a hard-X-ray photon index of Γ = 1.91 +0.24 -0.22 , which supports the virial L/L Edd determination in this source. Our results suggest that the weakness of the broad emission lines in WLQs is not a consequence of an extreme continuum-emission source but instead due to abnormal broad emission line region properties.

Search for Gamma-Ray Emission from Local Primordial Black Holes with the Fermi Large Area Telescope

Science.gov (United States)

Ackermann, M.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Berenji, B.; Bissaldi, E.; Blandford, R. D.; Bloom, E. D.; Bonino, R.; Bottacini, E.; Bregeon, J.; Bruel, P.; Buehler, R.; Cameron, R. A.; Caputo, R.; Caraveo, P. A.; Cavazzuti, E.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiaro, G.; Ciprini, S.; Cohen-Tanugi, J.; Conrad, J.; Costantin, D.; D’Ammando, F.; de Palma, F.; Digel, S. W.; Di Lalla, N.; Di Mauro, M.; Di Venere, L.; Favuzzi, C.; Fegan, S. J.; Focke, W. B.; Franckowiak, A.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Giglietto, N.; Giordano, F.; Giroletti, M.; Green, D.; Grenier, I. A.; Guillemot, L.; Guiriec, S.; Horan, D.; Jóhannesson, G.; Johnson, C.; Kensei, S.; Kocevski, D.; Kuss, M.; Larsson, S.; Latronico, L.; Li, J.; Longo, F.; Loparco, F.; Lovellette, M. N.; Lubrano, P.; Magill, J. D.; Maldera, S.; Malyshev, D.; Manfreda, A.; Mazziotta, M. N.; McEnery, J. E.; Meyer, M.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Monzani, M. E.; Moretti, E.; Morselli, A.; Moskalenko, I. V.; Negro, M.; Nuss, E.; Ojha, R.; Omodei, N.; Orienti, M.; Orlando, E.; Ormes, J. F.; Palatiello, M.; Paliya, V. S.; Paneque, D.; Persic, M.; Pesce-Rollins, M.; Piron, F.; Principe, G.; Rainò, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Ritz, S.; Sánchez-Conde, M.; Sgrò, C.; Siskind, E. J.; Spada, F.; Spandre, G.; Spinelli, P.; Suson, D. J.; Tajima, H.; Thayer, J. G.; Thayer, J. B.; Torres, D. F.; Tosti, G.; Troja, E.; Valverde, J.; Vianello, G.; Wood, K.; Wood, M.; Zaharijas, G.

2018-04-01

Black holes with masses below approximately 1015 g are expected to emit gamma-rays with energies above a few tens of MeV, which can be detected by the Fermi Large Area Telescope (LAT). Although black holes with these masses cannot be formed as a result of stellar evolution, they may have formed in the early universe and are therefore called primordial black holes (PBHs). Previous searches for PBHs have focused on either short-timescale bursts or the contribution of PBHs to the isotropic gamma-ray emission. We show that, in cases of individual PBHs, the Fermi-LAT is most sensitive to PBHs with temperatures above approximately 16 GeV and masses 6 × 1011 g, which it can detect out to a distance of about 0.03 pc. These PBHs have a remaining lifetime of months to years at the start of the Fermi mission. They would appear as potentially moving point sources with gamma-ray emission that become spectrally harder and brighter with time until the PBH completely evaporates. In this paper, we develop a new algorithm to detect the proper motion of gamma-ray point sources, and apply it to 318 unassociated point sources at a high galactic latitude in the third Fermi-LAT source catalog. None of the unassociated point sources with spectra consistent with PBH evaporation show significant proper motion. Using the nondetection of PBH candidates, we derive a 99% confidence limit on the PBH evaporation rate in the vicinity of Earth, {\\dot{ρ }}PBH}< 7.2× {10}3 {pc}}-3 {yr}}-1. This limit is similar to the limits obtained with ground-based gamma-ray observatories.

Residual Gas and Dust around Transition Objects and Weak T Tauri Stars

Energy Technology Data Exchange (ETDEWEB)

Doppmann, Greg W. [W. M. Keck Observatory, 65-1120 Mamalahoa Hwy., Kamuela, HI 96743 (United States); Najita, Joan R. [National Optical Astronomy Observatory, 950 N. Cherry Avenue, Tucson, AZ 85719 (United States); Carr, John S., E-mail: gdoppmann@keck.hawaii.edu, E-mail: najita@noao.edu, E-mail: carr@nrl.navy.mil [Naval Research Laboratory, Code 7213, Washington, DC 20375 (United States)

2017-02-20

Residual gas in disks around young stars can spin down stars, circularize the orbits of terrestrial planets, and whisk away the dusty debris that is expected to serve as a signpost of terrestrial planet formation. We have carried out a sensitive search for residual gas and dust in the terrestrial planet region surrounding young stars ranging in age from a few to ∼10 Myr. Using high-resolution 4.7 μ m spectra of transition objects (TOs) and weak T Tauri stars, we searched for weak continuum excesses and CO fundamental emission, after making a careful correction for the stellar contribution to the observed spectrum. We find that the CO emission from TOs is weaker and located farther from the star than CO emission from nontransition T Tauri stars with similar stellar accretion rates. The difference is possibly the result of chemical and/or dynamical effects (i.e., a low CO abundance or close-in low-mass planets). The weak T Tauri stars show no CO fundamental emission down to low flux levels (5 × 10{sup −20} to 10{sup −18} W m{sup −2}). We illustrate how our results can be used to constrain the residual disk gas content in these systems and discuss their potential implications for star and planet formation.

Cosmology with weak lensing surveys

International Nuclear Information System (INIS)

Munshi, Dipak; Valageas, Patrick; Waerbeke, Ludovic van; Heavens, Alan

2008-01-01

Weak gravitational lensing is responsible for the shearing and magnification of the images of high-redshift sources due to the presence of intervening matter. The distortions are due to fluctuations in the gravitational potential, and are directly related to the distribution of matter and to the geometry and dynamics of the Universe. As a consequence, weak gravitational lensing offers unique possibilities for probing the Dark Matter and Dark Energy in the Universe. In this review, we summarise the theoretical and observational state of the subject, focussing on the statistical aspects of weak lensing, and consider the prospects for weak lensing surveys in the future. Weak gravitational lensing surveys are complementary to both galaxy surveys and cosmic microwave background (CMB) observations as they probe the unbiased non-linear matter power spectrum at modest redshifts. Most of the cosmological parameters are accurately estimated from CMB and large-scale galaxy surveys, so the focus of attention is shifting to understanding the nature of Dark Matter and Dark Energy. On the theoretical side, recent advances in the use of 3D information of the sources from photometric redshifts promise greater statistical power, and these are further enhanced by the use of statistics beyond two-point quantities such as the power spectrum. The use of 3D information also alleviates difficulties arising from physical effects such as the intrinsic alignment of galaxies, which can mimic weak lensing to some extent. On the observational side, in the next few years weak lensing surveys such as CFHTLS, VST-KIDS and Pan-STARRS, and the planned Dark Energy Survey, will provide the first weak lensing surveys covering very large sky areas and depth. In the long run even more ambitious programmes such as DUNE, the Supernova Anisotropy Probe (SNAP) and Large-aperture Synoptic Survey Telescope (LSST) are planned. Weak lensing of diffuse components such as the CMB and 21 cm emission can also

Cosmology with weak lensing surveys

Energy Technology Data Exchange (ETDEWEB)

Munshi, Dipak [Institute of Astronomy, Madingley Road, Cambridge, CB3 OHA (United Kingdom); Astrophysics Group, Cavendish Laboratory, Madingley Road, Cambridge CB3 OHE (United Kingdom)], E-mail: munshi@ast.cam.ac.uk; Valageas, Patrick [Service de Physique Theorique, CEA Saclay, 91191 Gif-sur-Yvette (France); Waerbeke, Ludovic van [University of British Columbia, Department of Physics and Astronomy, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); Heavens, Alan [SUPA - Scottish Universities Physics Alliance, Institute for Astronomy, University of Edinburgh, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom)

2008-06-15

Weak gravitational lensing is responsible for the shearing and magnification of the images of high-redshift sources due to the presence of intervening matter. The distortions are due to fluctuations in the gravitational potential, and are directly related to the distribution of matter and to the geometry and dynamics of the Universe. As a consequence, weak gravitational lensing offers unique possibilities for probing the Dark Matter and Dark Energy in the Universe. In this review, we summarise the theoretical and observational state of the subject, focussing on the statistical aspects of weak lensing, and consider the prospects for weak lensing surveys in the future. Weak gravitational lensing surveys are complementary to both galaxy surveys and cosmic microwave background (CMB) observations as they probe the unbiased non-linear matter power spectrum at modest redshifts. Most of the cosmological parameters are accurately estimated from CMB and large-scale galaxy surveys, so the focus of attention is shifting to understanding the nature of Dark Matter and Dark Energy. On the theoretical side, recent advances in the use of 3D information of the sources from photometric redshifts promise greater statistical power, and these are further enhanced by the use of statistics beyond two-point quantities such as the power spectrum. The use of 3D information also alleviates difficulties arising from physical effects such as the intrinsic alignment of galaxies, which can mimic weak lensing to some extent. On the observational side, in the next few years weak lensing surveys such as CFHTLS, VST-KIDS and Pan-STARRS, and the planned Dark Energy Survey, will provide the first weak lensing surveys covering very large sky areas and depth. In the long run even more ambitious programmes such as DUNE, the Supernova Anisotropy Probe (SNAP) and Large-aperture Synoptic Survey Telescope (LSST) are planned. Weak lensing of diffuse components such as the CMB and 21 cm emission can also

Parsec-Scale Radio Properties of Gamma-ray Bright Blazars

Science.gov (United States)

Linford, Justin

2012-01-01

The parsec-scale radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been investigated using observations with the Very Long Baseline Array (VLBA). Comparisons between LAT and non-LAT detected samples were made using both archival and contemporaneous data. In total, 244 sources were used in the LAT-detected sample. This very large, radio flux-limited sample of active galactic nuclei (AGN) provides insights into the mechanism that produces strong gamma-ray emission. It has been found that LAT-detected BL Lac objects are very similar to the non-LAT BL Lac objects in most properties, although LAT BL Lac objects may have longer jets. The LAT flat spectrum radio quasars (FSRQs) are significantly different from non-LAT FSRQs and are likely extreme members of the FSRQ population. Archival radio data indicated that there was no significant correlation between radio flux density and gamma-ray flux, especially at lower flux levels. However, contemporaneous observations showed a strong correlation. Most of the differences between the LAT and non-LAT populations are related to the cores of the sources, indicating that the gamma-ray emission may originate near the base of the jets (i.e., within a few pc of the central engine). There is some indication that LAT-detected sources may have larger jet opening angles than the non-LAT sources. Strong core polarization is significantly more common among the LAT sources, suggesting that gamma-ray emission is related to strong, uniform magnetic fields at the base of the jets of the blazars. Observations of sources in two epochs indicate that core fractional polarization was higher when the objects were detected by the LAT. Included in our sample are several non-blazar AGN such as 3C84, M82, and NGC 6251.

Electromagnetic weak turbulence theory revisited

Energy Technology Data Exchange (ETDEWEB)

Yoon, P. H. [IPST, University of Maryland, College Park, Maryland 20742 (United States); Ziebell, L. F. [Instituto de Fisica, UFRGS, Porto Alegre, RS (Brazil); Gaelzer, R.; Pavan, J. [Instituto de Fisica e Matematica, UFPel, Pelotas, RS (Brazil)

2012-10-15

The statistical mechanical reformulation of weak turbulence theory for unmagnetized plasmas including fully electromagnetic effects was carried out by Yoon [Phys. Plasmas 13, 022302 (2006)]. However, the wave kinetic equation for the transverse wave ignores the nonlinear three-wave interaction that involves two transverse waves and a Langmuir wave, the incoherent analogue of the so-called Raman scattering process, which may account for the third and higher-harmonic plasma emissions. The present paper extends the previous formalism by including such a term.

Revisiting simplified dark matter models in terms of AMS-02 and Fermi-LAT

Science.gov (United States)

Li, Tong

2018-01-01

We perform an analysis of the simplified dark matter models in the light of cosmic ray observables by AMS-02 and Fermi-LAT. We assume fermion, scalar or vector dark matter particle with a leptophobic spin-0 mediator that couples only to Standard Model quarks and dark matter via scalar and/or pseudo-scalar bilinear. The propagation and injection parameters of cosmic rays are determined by the observed fluxes of nuclei from AMS-02. We find that the AMS-02 observations are consistent with the dark matter framework within the uncertainties. The AMS-02 antiproton data prefer 30 (50) GeV - 5 TeV dark matter mass and require an effective annihilation cross section in the region of 4 × 10-27 (7 × 10-27) - 4 × 10-24 cm3/s for the simplified fermion (scalar and vector) dark matter models. The cross sections below 2 × 10-26 cm3/s can evade the constraint from Fermi-LAT dwarf galaxies for about 100 GeV dark matter mass.

Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs.

Science.gov (United States)

Napolitano, Lara; Scalise, Mariafrancesca; Koyioni, Maria; Koutentis, Panayiotis; Catto, Marco; Eberini, Ivano; Parravicini, Chiara; Palazzolo, Luca; Pisani, Leonardo; Galluccio, Michele; Console, Lara; Carotti, Angelo; Indiveri, Cesare

2017-11-01

The LAT1 transporter is acknowledged as a pharmacological target of tumours since it is strongly overexpressed in many human cancers. The purpose of this work was to find novel compounds exhibiting potent and prolonged inhibition of the transporter. To this aim, compounds based on dithiazole and dithiazine scaffold have been screened in the proteoliposome experimental model. Inhibition was tested on the antiport catalysed by hLAT1 as transport of extraliposomal [ 3 H]histidine in exchange with intraliposomal histidine. Out of 59 compounds tested, 8 compounds, showing an inhibition higher than 90% at 100µM concentration, were subjected to dose-response analysis. Two of them exhibited IC 50 lower than 1µM. Inhibition kinetics, performed on the two best inhibitors, indicated a mixed type of inhibition with respect to the substrate. Furthermore, inhibition of the transporter was still present after removal of the compounds from the reaction mixture, but was reversed on addition of dithioerythritol, a S-S reducing agent, indicating the formation of disulfide(s) between the compounds and the protein. Molecular docking of the two best inhibitors on the hLAT1 homology structural model, highlighted interaction with the substrate binding site and formation of a covalent bond with the residue C407. Indeed, the inhibition was impaired in the hLAT1 mutant C407A confirming the involvement of that Cys residue. Treatment of SiHa cells expressing hLAT1 at relatively high level, with the two most potent inhibitors led to cell death which was not observed after treatment with a compound exhibiting very poor inhibitory effect. Copyright © 2017 Elsevier Inc. All rights reserved.

Diagnostic usefulness of 18F-FAMT PET and L-type amino acid transporter 1 (LAT1) expression in oral squamous cell carcinoma

International Nuclear Information System (INIS)

Nobusawa, Aiko; Kim, Mai; Kaira, Kyoichi; Miyashita, Go; Negishi, Akihide; Yokoo, Satoshi; Oriuchi, Noboru; Higuchi, Tetsuya; Tsushima, Yoshito; Kanai, Yoshikatsu; Oyama, Tetsunari

2013-01-01

l-[3- 18 F]-α-Methyltyrosine ( 18 F-FAMT) was developed as an amino acid tracer for PET imaging to provide better specificity than 2-[ 18 F]fluoro-2-deoxy-d-glucose ( 18 F-FDG) PET for cancer diagnosis. We investigated the diagnostic usefulness of 18 F-FAMT in oral squamous cell carcinoma (OSCC). The correlation between tumour uptake of 18 F-FAMT and L-type amino acid transporter 1 (LAT1) expression was determined. The study group comprised 68 OSCC patients who underwent both 18 F-FAMT and 18 F-FDG PET. Resected tumour sections were stained by immunohistochemistry for LAT1, CD98 and Ki-67, and microvessel density was determined in terms of CD34 and p53 expression. The sensitivity of primary tumour detection by 18 F-FAMT and 18 F-FDG PET was 98 % and 100 %, respectively. The sensitivity, specificity and accuracy of 18 F-FAMT PET for detecting malignant lymph nodes were 68 %, 99 % and 97 %, respectively, and equivalent values for 18 F-FDG PET were 84 %, 94 % and 94 %, respectively. The specificity and accuracy of 18 F-FAMT were significantly higher than those of 18 F-FDG. The uptake of 18 F-FAMT was significantly correlated with LAT1 expression, cell proliferation and advanced stage. The expression of LAT1 in OSCC cells was closely correlated with CD98 levels, cell proliferation and angiogenesis. 18 F-FAMT PET showed higher specificity for detecting malignant lesions than 18 F-FDG PET. The uptake of 18 F-FAMT by OSCC cells can be determined by the presence of LAT1 expression and tumour cell proliferation. (orig.)

50 CFR Table 3 (north) to Part 660... - 2010 Trip Limits for Open Access Gears North of 40°10′ N. Lat.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2010 Trip Limits for Open Access Gears North of 40°10â² N. Lat. 3 Table 3 (North) to Part 660, Subpart F Wildlife and Fisheries FISHERY... Limits for Open Access Gears North of 40°10′ N. Lat. ER01OC10.020 ER01OC10.021 ...

50 CFR Table 3 (south) to Part 660... - 2010 Trip Limits for Open Access Gears South of 40°10′ N. Lat.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2010 Trip Limits for Open Access Gears South of 40°10â² N. Lat. 3 Table 3 (South) to Part 660, Subpart F Wildlife and Fisheries FISHERY... Limits for Open Access Gears South of 40°10′ N. Lat. ER01OC10.022 ER01OC10.023 ...

Jet emission in young radio sources: A Fermi large area telescope gamma-ray view

Energy Technology Data Exchange (ETDEWEB)

Migliori, G.; Siemiginowska, A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden St., Cambridge, MA 02138 (United States); Kelly, B. C. [Department of Physics, Broida Hall, University of California, Santa Barbara, CA 93107 (United States); Stawarz, Ł. [Institute of Space and Astronautical Science, JAXA, 3-1-1 Yoshinodai, Chuo-ku, Sagamihara, Kanagawa 252-5210 (Japan); Celotti, A. [Scuola Internazionale Superiore di Studi Avanzati (SISSA), via Bonomea, 265-34136 Trieste (Italy); Begelman, M. C., E-mail: migliori@cfa.harvard.edu [JILA, University of Colorado and National Institute of Standards and Technology, 440 UCB, Boulder, CO 80309-0440 (United States)

2014-01-10

We investigate the contribution of the beamed jet component to the high-energy emission in young and compact extragalactic radio sources, focusing for the first time on the γ-ray band. We derive predictions on the γ-ray luminosities associated with the relativistic jet assuming a leptonic radiative model. The high-energy emission is produced via Compton scattering by the relativistic electrons in a spherical region at the considered scales (≲10 kpc). Simulations show a wide range of γ-ray luminosities, with intensities up to ∼10{sup 46}-10{sup 48} erg s{sup –1} depending on the assumed jet parameters. We find a highly linear relation between the simulated X-ray and γ-ray luminosities that can be used to select candidates for γ-ray detection. We compare the simulated luminosity distributions in the radio, X-ray, and γ-ray regimes with observations for the largest sample of X-ray-detected young radio quasars. Our analysis of ∼4-yr Fermi Large Area Telescope (LAT) data does not yield any statistically significant detections. However, the majority of the model-predicted γ-ray fluxes for the sample are near or below the current Fermi-LAT flux threshold and compatible with the derived upper limits. Our study gives constraints on the minimum jet power (L {sub jet,} {sub kin}/L {sub disk} > 0.01) of a potential jet contribution to the X-ray emission in the most compact sources (≲ 1 kpc) and on the particle-to-magnetic field energy density ratio that are in broad agreement with equipartition assumptions.

Fermi-LAT View of Bright Flaring Gamma-Ray Blazars D. Bastieri1,2 ...

Indian Academy of Sciences (India)

Sun while in a quiet state were promptly detected. This is mainly due to the design of the mission, featuring a detector, the LAT with a wide field of view, and to ... the energies of all photons falling inside a solid angle, of a proper opening, cen- ... Opportunity (ToO) triggers for multifrequency observations; to start possible ToO.

OMI/Aura Surface Reflectance Climatology Level 3 Global 0.5deg Lat/Lon Grid V003

Data.gov (United States)

National Aeronautics and Space Administration — The OMI Earth Surface Reflectance Climatology product, OMLER (Global 0.5deg Lat/Lon grid) which is based on Version 003 Level-1B top of atmosphere upwelling radiance...

miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.

Directory of Open Access Journals (Sweden)

Alexandre K Rouquette-Jazdanian

Full Text Available Linker for Activation of T cells (LAT is an adapter protein that is essential for T cell function. Knock-in mice with a LAT mutation impairing calcium flux develop a fatal CD4+ lymphoproliferative disease. miR-155 is a microRNA that is correlated with hyperproliferation in a number of cancers including lymphomas and leukemias and is overexpressed in mutant LAT T cells. To test whether miR-155 was merely indicative of T cell activation or whether it contributes to lymphoproliferative disease in mutant LAT mice, we interbred LAT mutant and miR-155-deficient mice. miR-155 deficiency markedly inhibited lymphoproliferative disease by stimulating BIM-dependent CD4+ T cell apoptosis, even though ERK activation and T cell proliferation were increased in double mutant CD4+ T cells. Bim/Bcl2l11 expression is activated by the forkhead transcription factor FOXO3. Using miR-155-deficient, LAT mutant T cells as a discovery tool, we found two connected pathways that impact the nuclear translocation and activation of FOXO3 in T cells. One pathway is mediated by the inositide phosphatase SHIP-1 and the serine/threonine kinases AKT and PDK1. The other pathway involves PAK1 and JNK kinase activation. We define crosstalk between the two pathways via the kinase mTOR, which stabilizes PAK1. This study establishes a role for PAK1 in T cell apoptosis, which contrasts to its previously identified role in T cell proliferation. Furthermore, miR-155 regulates the delicate balance between PAK1-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.

Nocturama gen. nov., Nothocladus s. lat. and other taxonomic novelties resulting from the further resolution of paraphyly in Australasian members of Batrachospermum (Batrachospermales, Rhodophyta).

Science.gov (United States)

Entwisle, Timothy J; Johnston, Emily T; Lam, Daryl W; Stewart, Sarah A; Vis, Morgan L

2016-06-01

The informal "Australasica Group" was established in 2009 to include several Australasian endemic Batrachospermum species, a few species of the cosmopolitan Batrachospermum section Setacea, and the South American endemic Petrohua bernabei. Although useful for communication purposes, no formal taxonomic designation was proposed due to weakly supported basal nodes. The present research took a two-pronged approach of adding more taxa (29 additional specimens) as well as more sequence data (LSU, cox1, psaA, and psbA markers added to rbcL data) to provide better resolution. The resulting tree showed improved statistical support values (Bayesian posterior probability and maximum likelihood bootstrap) for most nodes providing a framework for taxonomic revision. Based on our well-resolved phylogeny, a new genus, Nocturama, is proposed for a clade of Batrachospermum antipodites specimens. The circumscription of Nothocladus is expanded to include Batrachospermum section Setacea and four additional sections composed of at least 10 species, mostly from Australia and New Zealand. One new species added to the data set, N. diatyches, did not form a clade with the other species of section Setaceus, where it was classified previously, rendering that section paraphyletic. To resolve this, N. diatyches and the morphologically similar species N. latericius are included with N. theaquus, in the new section Theaquus within Nothocladus s. lat. A specimen from Australia unaligned to these clades was sister to the Australia-New Zealand genus Psilosiphon and the cosmopolitan B. cayennense, but lacked statistical support. This specimen has the gross morphology of Batrachospermum s. lat. and is here provisionally assigned to that genus, as B. serendipidum sp. nov. © 2016 Phycological Society of America.

Examining the nature of very-high-energy gamma-ray emission from the AGN PKS 1222+216 and 3C 279

Science.gov (United States)

Price, Sharleen; Brill, Ari; Mukherjee, Reshmi; VERITAS

2018-01-01

Blazars are a type of active galactic nuclei (AGN) that emit jets of ionized matter which move towards the Earth at relativistic speeds. In this research we carried out a study of two objects, 3C 279 and PKS 1222+216, which belong to the subset of blazars known as FSRQs (flat spectrum radio quasars), the most powerful TeV-detected sources at gamma-ray energies with bolometric luminosities exceeding 1048 erg/s. The high-energy emission of quasars peaks in the MeV-GeV band, making these sources very rarely detectable in the TeV energy range. In fact, only six FSRQs have ever been detected in this range by very-high-energy gamma-ray telescopes. We will present results from observing campaigns on 3C 279 in 2014 and 2016, when the object was detected in high flux states by Fermi-LAT. Observations include simultaneous coverage with the Fermi-LAT satellite and the VERITAS ground-based array spanning four decades in energy from 100 MeV to 1 TeV. We will also report VERITAS observations of PKS 1222+216 between 2008 and 2017. The detection/non-detection of TeV emission during flaring episodes at MeV energies will further contribute to our understanding of particle acceleration and gamma-ray emission mechanisms in blazar jets.

Bursts of the Crab Nebula gamma-ray emission at high and ultra-high energies

Directory of Open Access Journals (Sweden)

Lidvansky A.S.

2017-01-01

Full Text Available Characteristics of the flares of gamma rays detected from the Crab Nebula by the AGILE and Fermi-LAT satellite instruments are compared with those of a gamma ray burst recorded by several air shower arrays on February 23, 1989 and with one recent observation made by the ARGO-YBJ array. It is demonstrated that though pulsar-periodicity and energy spectra of emissions at 100 MeV (satellite gamma ray telescopes and 100 TeV (EAS arrays are different, their time structures seem to be similar. Moreover, maybe the difference between “flares” and “waves” recently found in the Crab Nebula emission by the AGILE team also exists at ultra-high energies.

Reconstructing weak values without weak measurements

International Nuclear Information System (INIS)

Johansen, Lars M.

2007-01-01

I propose a scheme for reconstructing the weak value of an observable without the need for weak measurements. The post-selection in weak measurements is replaced by an initial projector measurement. The observable can be measured using any form of interaction, including projective measurements. The reconstruction is effected by measuring the change in the expectation value of the observable due to the projector measurement. The weak value may take nonclassical values if the projector measurement disturbs the expectation value of the observable

FERMI/LAT OBSERVATIONS OF SWIFT/BAT SEYFERT GALAXIES: ON THE CONTRIBUTION OF RADIO-QUIET ACTIVE GALACTIC NUCLEI TO THE EXTRAGALACTIC γ-RAY BACKGROUND

International Nuclear Information System (INIS)

Teng, Stacy H.; Mushotzky, Richard F.; Reynolds, Christopher S.; Sambruna, Rita M.; Davis, David S.

2011-01-01

We present the analysis of 2.1 years of Fermi Large Area Telescope (LAT) data on 491 Seyfert galaxies detected by the Swift Burst Alert Telescope (BAT) survey. Only the two nearest objects, NGC 1068 and NGC 4945, which were identified in the Fermi first year catalog, are detected. Using Swift/BAT and radio 20 cm fluxes, we define a new radio-loudness parameter R X,BAT where radio-loud objects have log R X,BAT > –4.7. Based on this parameter, only radio-loud sources are detected by Fermi/LAT. An upper limit to the flux of the undetected sources is derived to be ∼2 × 10 –11 photons cm –2 s –1 , approximately seven times lower than the observed flux of NGC 1068. Assuming a median redshift of 0.031, this implies an upper limit to the γ-ray (1-100 GeV) luminosity of ∼ 41 erg s –1 . In addition, we identified 120 new Fermi/LAT sources near the Swift/BAT Seyfert galaxies with significant Fermi/LAT detections. A majority of these objects do not have Swift/BAT counterparts, but their possible optical counterparts include blazars, flat-spectrum radio quasars, and quasars.

Diffuse γ-ray emission observed by the Fermi large area telescope: massive stars, cosmic rays and the census of the interstellar medium in the galaxy

International Nuclear Information System (INIS)

Tibaldo, L.

2011-01-01

Galactic diffuse γ-ray emission is produced by interactions of cosmic rays (CRs) with interstellar gas and low-energy radiation fields. This is the brightest component of the high-energy γ-ray sky, surveyed since 2008 with unprecedented sensitivity and angular resolution by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. Galactic diffuse emission constitutes not only a bright and structured background which needs to be modeled in order to study individual sources and fainter diffuse components, but it can be used also as a probe of the interstellar environment of the Milky Way. We present in-depth studies of LAT γ-ray observations of selected regions in the local and outer Galaxy. LAT data are compared with multiwavelength tracers of the interstellar medium (ISM), including radio/mm-wave lines of gas and infrared emission/extinction from dust. The impact of the HI optical depth, often overlooked in the past, is carefully examined and recognized currently as the dominant source of uncertainty in the interpretation of observations. On one hand, we discuss the constraints provided by the γ-ray data on the census of the interstellar gas. We determine the X C O = N(H 2 )/W C O ratio for several clouds, finding no significant gradients in the Galactic disc over a range of ∼ 3.5 kpc in Galactocentric radius, and variations of a factor ≤ 2 in nearby local clouds. We also find evidence for an ubiquitous dark phase of interstellar gas which does not shine at radio/mm wavelengths and which provides a mass ∼ 50% of that traced by CO. For the first time we determine its γ-ray spectrum which is found to be well correlated with that of HI, thus further confirming that the emission originates from interstellar gas. On the other hand, we use the emissivity per hydrogen atom to infer the distribution of CRs in distant locations not accessible by direct measurements. While the local HI emissivity is consistent with the CR spectra measured near

50 CFR Table 5 (south) to Part 660... - 2009-2010 Trip Limits for Open Access Gears South of 40°10′ N. Lat.

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2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2009-2010 Trip Limits for Open Access Gears South of 40°10â² N. Lat. 5 Table 5 (South) to Part 660, Subpart G Wildlife and Fisheries FISHERY... Trip Limits for Open Access Gears South of 40°10′ N. Lat. Link to an amendment published at 75 FR 60995...

50 CFR Table 5 (north) to Part 660... - 2009-2010 Trip Limits for Open Access Gears North of 40°10′ N. Lat.

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2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2009-2010 Trip Limits for Open Access Gears North of 40°10â² N. Lat. 5 Table 5 (North) to Part 660, Subpart G Wildlife and Fisheries FISHERY... Trip Limits for Open Access Gears North of 40°10′ N. Lat. Link to an amendment published at 75 FR 60995...

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.

Science.gov (United States)

Huang, William Y C; Yan, Qingrong; Lin, Wan-Chen; Chung, Jean K; Hansen, Scott D; Christensen, Sune M; Tu, Hsiung-Lin; Kuriyan, John; Groves, Jay T

2016-07-19

The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is known about how these assemblies modulate reaction kinetics and the ultimate propagation of signals. Here, we reconstitute phosphotyrosine-mediated assembly of extended linker for the activation of T cells (LAT):growth factor receptor-bound protein 2 (Grb2):Son of Sevenless (SOS) networks, derived from the T-cell receptor signaling system, on supported membranes. Single-molecule dwell time distributions reveal two, well-differentiated kinetic species for both Grb2 and SOS on the LAT assemblies. The majority fraction of membrane-recruited Grb2 and SOS both exhibit fast kinetics and single exponential dwell time distributions, with average dwell times of hundreds of milliseconds. The minor fraction exhibits much slower kinetics, extending the dwell times to tens of seconds. Considering this result in the context of the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is activated indicates that kinetic stabilization from the LAT assembly may be important. This kinetic proofreading effect would additionally serve as a stochastic noise filter by reducing the relative probability of spontaneous SOS activation in the absence of receptor triggering. The generality of receptor-mediated assembly suggests that such effects may play a role in multiple receptor proximal signaling processes.

THE FIRST FERMI-LAT CATALOG OF SOURCES ABOVE 10 GeV

International Nuclear Information System (INIS)

Ackermann, M.; Buehler, R.; Ajello, M.; Allafort, A.; Bechtol, K.; Bloom, E. D.; Atwood, W. B.; Belfiore, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bregeon, J.; Bernieri, E.; Bissaldi, E.; Bonamente, E.; Brandt, T. J.; M. Merlin dell'Università e del Politecnico di Bari, I-70126 Bari (Italy))" data-affiliation=" (Dipartimento di Fisica M. Merlin dell'Università e del Politecnico di Bari, I-70126 Bari (Italy))" >Brigida, M.; Bruel, P.

2013-01-01

We present a catalog of γ-ray sources at energies above 10 GeV based on data from the Large Area Telescope (LAT) accumulated during the first 3 yr of the Fermi Gamma-ray Space Telescope mission. The first Fermi-LAT catalog of >10 GeV sources (1FHL) has 514 sources. For each source we present location, spectrum, a measure of variability, and associations with cataloged sources at other wavelengths. We found that 449 (87%) could be associated with known sources, of which 393 (76% of the 1FHL sources) are active galactic nuclei. Of the 27 sources associated with known pulsars, we find 20 (12) to have significant pulsations in the range >10 GeV (>25 GeV). In this work we also report that, at energies above 10 GeV, unresolved sources account for 27% ± 8% of the isotropic γ-ray background, while the unresolved Galactic population contributes only at the few percent level to the Galactic diffuse background. We also highlight the subset of the 1FHL sources that are best candidates for detection at energies above 50-100 GeV with current and future ground-based γ-ray observatories

Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells

Energy Technology Data Exchange (ETDEWEB)

Le Vee, Marc; Jouan, Elodie; Lecureur, Valérie [Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes (France); Fardel, Olivier, E-mail: olivier.fardel@univ-rennes1.fr [Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes (France); Pôle Biologie, Centre Hospitalier Universitaire, 2 rue Henri Le Guilloux, 35033 Rennes (France)

2016-01-01

The heterodimeric L-type amino acid transporter (LAT) 1/CD98hc is overexpressed in lung cancers with a poor prognosis factor. Factors that contribute to LAT1/CD98hc overexpression in lung cells remain however to be determined, but the implication of atmospheric pollution can be suspected. The present study was therefore designed to analyze the effects of diesel exhaust particle (DEP) extract (DEPe) on LAT1/CD98hc expression in bronchial epithelial BEAS-2B cells. Exposure to DEPe up-regulated LAT1 and CD98hc mRNA levels in a concentration-dependent manner, with DEPe EC{sub 50} values (around 0.2 μg/mL) relevant to environmental situations. DEPe concomitantly induced LAT1/CD98hc protein expression and LAT1-mediated leucine accumulation in BEAS-2B cells. Inhibition of the aryl hydrocarbon receptor (AhR) pathway through the use of a chemical AhR antagonist or the siRNA-mediated silencing of AhR expression was next found to prevent DEPe-mediated induction of LAT1/CD98hc, indicating that this regulation depends on AhR, known to be activated by major chemical DEP components like polycyclic aromatic hydrocarbons. DEPe exposure was finally shown to induce mRNA expression and activity of matrix metalloproteinase (MMP)-2 in BEAS-2B cells, in a CD98hc/focal adhesion kinase (FAK)/extracellular regulated kinase (ERK) manner, thus suggesting that DEPe-mediated induction of CD98hc triggers activation of the integrin/FAK/ERK signaling pathway known to be involved in MMP-2 regulation. Taken together, these data demonstrate that exposure to DEPe induces functional overexpression of the amino acid transporter LAT1/CD98hc in lung cells. Such a regulation may participate to pulmonary carcinogenic effects of DEPs, owing to the well-documented contribution of LAT1 and CD98hc to cancer development. - Highlights: • The amino acid transporter LAT1/CD98hc is up-regulated in DEPe-treated lung cells. • The aryl hydrocarbon receptor is involved in DEPe-triggered induction of LAT1/CD98hc. �

A Chandra Survey of Milky Way Globular Clusters. I. Emissivity and Abundance of Weak X-Ray Sources

Science.gov (United States)

Cheng, Zhongqun; Li, Zhiyuan; Xu, Xiaojie; Li, Xiangdong

2018-05-01

Based on archival Chandra data, we have carried out an X-ray survey of 69, or nearly half the known population of, Milky Way globular clusters (GCs), focusing on weak X-ray sources, mainly cataclysmic variables (CVs) and coronally active binaries (ABs). Using the cumulative X-ray luminosity per unit stellar mass (i.e., X-ray emissivity) as a proxy of the source abundance, we demonstrate a paucity (lower by 41% ± 27% on average) of weak X-ray sources in most GCs relative to the field, which is represented by the Solar Neighborhood and Local Group dwarf elliptical galaxies. We also revisit the mutual correlations among the cumulative X-ray luminosity (L X), cluster mass (M), and stellar encounter rate (Γ), finding {L}{{X}}\\propto {M}0.74+/- 0.13, {L}{{X}}\\propto {{{Γ }}}0.67+/- 0.07 and {{Γ }}\\propto {M}1.28+/- 0.17. The three quantities can further be expressed as {L}{{X}}\\propto {M}0.64+/- 0.12 {{{Γ }}}0.19+/- 0.07, which indicates that the dynamical formation of CVs and ABs through stellar encounters in GCs is less dominant than previously suggested, and that the primordial formation channel has a substantial contribution. Taking these aspects together, we suggest that a large fraction of primordial, soft binaries have been disrupted in binary–single or binary–binary stellar interactions before they could otherwise evolve into X-ray-emitting close binaries, whereas the same interactions also have led to the formation of new close binaries. No significant correlations between {L}{{X}}/{L}K and cluster properties, including dynamical age, metallicity, and structural parameters, are found.

Pulsar Emission Spectrum

OpenAIRE

Gruzinov, Andrei

2013-01-01

Emission spectrum is calculated for a weak axisymmetric pulsar. Also calculated are the observed spectrum, efficiency, and the observed efficiency. The underlying flow of electrons and positrons turns out to be curiously intricate.

VizieR Online Data Catalog: Fermi LAT second source catalog (2FGL) (Nolan+, 2012)

Science.gov (United States)

Nolan, P. L.; Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Antolini, E.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Belfiore, A.; Bellazzini, R.; Berenji, B.; Bignami, G. F.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Bonnell, J.; Borgland, A. W.; Bottacini, E.; Bouvier, A.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Burnett, T. H.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Campana, R.; Canadas, B.; Cannon, A.; Caraveo, P. A.; Casandjian, J. M.; Cavazzuti, E.; Ceccanti, M.; Cecchi, C.; Celik, O.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Chipaux, R.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Cominsky, L. R.; Conrad, J.; Corbet, R.; Cutini, S.; D'Ammando, F.; Davis, D. S.; de Angelis, A.; Decesar, M. E.; Deklotz, M.; de Luca A.; den Hartog, P. R.; de Palma, F.; Dermer, C. D.; Digel, S. W.; Do Couto, E. Silva E.; Drell, P. S.; Drlica-Wagner, A.; Dubois, R.; Dumora, D.; Enoto, T.; Escande, L.; Fabiani, D.; Falletti, L.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Focke, W. B.; Fortin, P.; Frailis, M.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Germani, S.; Giebels, B.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guillemot, L.; Guiriec, S.; Gustafsson, M.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Hill, A. B.; Horan, D.; Hou, X.; Hughes, R. E.; Iafrate, G.; Itoh, R.; Johannesson, G.; Johnson, R. P.; Johnson, T. E.; Johnson, A. S.; Johnson, T. J.; Kamae, T.; Katagiri, H.; Kataoka, J.; Katsuta, J.; Kawai, N.; Kerr, M.; Knodlseder, J.; Kocevski, D.; Kuss, M.; Lande, J.; Landriu, D.; Latronico, L.; Lemoine-Goumard, M.; Lionetto, A. M.; Llena Garde, M.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Madejski, G. M.; Marelli, M.; Massaro, E.; Mazziotta, M. N.; McConville, W.; McEnery, J. E.; Mehault, J.; Michelson, P. F.; Minuti, M.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Mongelli, M.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nakamori, T.; Naumann-God, O. M.; Norris, J. P.; Nuss, E.; Nymark, T.; Ohno, M.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orlando, E.; Ormes, J. F.; Ozaki, M.; Paneque, D.; Panetta, J. H.; Parent, D.; Perkins, J. S.; Pesce-Rollins, M.; Pierbattista, M.; Pinchera, M.; Piron, F.; Pivato, G.; Porter, T. A.; Racusin, J. L.; Raino, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Reposeur, T.; Ritz, S.; Rochester, L. S.; Romani, R. W.; Roth, M.; Rousseau, R.; Ryde, F.; Sadrozinski, H. F.-W.; Salvetti, D.; Sanchez, D. A.; Saz Parkinson, P. M.; Sbarra, C.; Scargle, J. D.; Schalk, T. L.; Sgro, C.; Shaw, M. S.; Shrader, C.; Siskind, E. J.; Smith, D. A.; Spandre, G.; Spinelli, P.; Stephens, T. E.; Strickman, M. S.; Suson, D. J.; Tajima, H.; Takahashi, H.; Takahashi, T.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tibolla, O.; Tinebra, F.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Uchiyama, Y.; Vandenbroucke, J.; van Etten, A.; van Klaveren, B.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Wallace, E.; Wang, P.; Werner, M.; Winer, B. L.; Wood, D. L.; Wood, K. S.; Wood, M.; Yang, Z.; Zimmer, S.

2012-06-01

This paper presents a catalog of high-energy γ-ray sources detected, in the 100MeV-100GeV energy range, in the first two years of the Fermi Gamma-ray Space Telescope mission by the Large Area Telescope (LAT), during the period 2008 August 4 (15:43 UTC)-2010 August 1 (01:17 UTC). (4 data files).

A radio survey of weak T Tauri stars in Taurus-Auriga

International Nuclear Information System (INIS)

O'neal, D.; Feigelson, E.D.; Mathieu, R.D.; Myers, P.C.

1990-01-01

A multi-epoch 5 GHz survey of candidate or confirmed weak T Tauri stars in the Taurus-Auriga molecular cloud complex was conducted with the Very Large Array. The stars were chosen from those having detectable X-ray or chromospheric emission, and weak-emission-line pre-main-sequence stars found by other means. Snapshots of 99 VLA fields containing 119 candidate stars were obtained with a sensitivity of 0.7 mJy; most fields were observed on two or three dates. Nine radio sources coincident with cataloged stars were found. One may be an RS CVn binary system; the other eight are pre-main-sequence stars. Three of the detected stars - HD 283447, V410 Tau, and FK X-ray 1 - were previously known radio sources. Five new detections are Herbig's Anon 1, Hubble 4, HDE 283572, Elias 12, and HK Tau/c. At least five of the sources are variable, and no linear or circular polarization was found. Several lines of evidence suggest that the radio-detected weak T Tauri stars are quite young, perhaps younger on average than nondetected stars. 54 refs

Diagnostic usefulness of {sup 18}F-FAMT PET and L-type amino acid transporter 1 (LAT1) expression in oral squamous cell carcinoma

Energy Technology Data Exchange (ETDEWEB)

Nobusawa, Aiko [Gunma University Graduate School of Medicine, Department of Stomatology and Maxillofacial Surgery, Maebashi, Gunma (Japan); Gunma University Graduate School of Medicine, Department of Diagnostic Pathology, Maebashi, Gunma (Japan); Kim, Mai [Gunma University Graduate School of Medicine, Department of Stomatology and Maxillofacial Surgery, Maebashi, Gunma (Japan); Gunma University Graduate School of Medicine, Department of Diagnostic Radiology and Nuclear Medicine, Maebashi, Gunma (Japan); Kaira, Kyoichi [Gunma University Graduate School of Medicine, Department of Diagnostic Pathology, Maebashi, Gunma (Japan); Gunma University Hospital, Oncology Center, Maebashi, Gunma (Japan); Miyashita, Go; Negishi, Akihide; Yokoo, Satoshi [Gunma University Graduate School of Medicine, Department of Stomatology and Maxillofacial Surgery, Maebashi, Gunma (Japan); Oriuchi, Noboru; Higuchi, Tetsuya; Tsushima, Yoshito [Gunma University Graduate School of Medicine, Department of Diagnostic Radiology and Nuclear Medicine, Maebashi, Gunma (Japan); Kanai, Yoshikatsu [Osaka University, Division of Bio-system Pharmacology, Graduate School of Medicine, Osaka (Japan); Oyama, Tetsunari [Gunma University Graduate School of Medicine, Department of Diagnostic Pathology, Maebashi, Gunma (Japan)

2013-10-15

l-[3-{sup 18}F]-{alpha}-Methyltyrosine ({sup 18}F-FAMT) was developed as an amino acid tracer for PET imaging to provide better specificity than 2-[{sup 18}F]fluoro-2-deoxy-d-glucose ({sup 18}F-FDG) PET for cancer diagnosis. We investigated the diagnostic usefulness of {sup 18}F-FAMT in oral squamous cell carcinoma (OSCC). The correlation between tumour uptake of {sup 18}F-FAMT and L-type amino acid transporter 1 (LAT1) expression was determined. The study group comprised 68 OSCC patients who underwent both {sup 18}F-FAMT and {sup 18}F-FDG PET. Resected tumour sections were stained by immunohistochemistry for LAT1, CD98 and Ki-67, and microvessel density was determined in terms of CD34 and p53 expression. The sensitivity of primary tumour detection by {sup 18}F-FAMT and {sup 18}F-FDG PET was 98 % and 100 %, respectively. The sensitivity, specificity and accuracy of {sup 18}F-FAMT PET for detecting malignant lymph nodes were 68 %, 99 % and 97 %, respectively, and equivalent values for {sup 18}F-FDG PET were 84 %, 94 % and 94 %, respectively. The specificity and accuracy of {sup 18}F-FAMT were significantly higher than those of {sup 18}F-FDG. The uptake of {sup 18}F-FAMT was significantly correlated with LAT1 expression, cell proliferation and advanced stage. The expression of LAT1 in OSCC cells was closely correlated with CD98 levels, cell proliferation and angiogenesis. {sup 18}F-FAMT PET showed higher specificity for detecting malignant lesions than {sup 18}F-FDG PET. The uptake of {sup 18}F-FAMT by OSCC cells can be determined by the presence of LAT1 expression and tumour cell proliferation. (orig.)

Dark matter in the Reticulum II dSph: a radio search

Science.gov (United States)

Regis, Marco; Richter, Laura; Colafrancesco, Sergio

2017-07-01

We present a deep radio search in the Reticulum II dwarf spheroidal (dSph) galaxy performed with the Australia Telescope Compact Array. Observations were conducted at 16 cm wavelength, with an rms sensitivity of 0.01 mJy/beam, and with the goal of searching for synchrotron emission induced by annihilation or decay of weakly interacting massive particles (WIMPs). Data were complemented with observations on large angular scales taken with the KAT-7 telescope. We find no evidence for a diffuse emission from the dSph and we derive competitive bounds on the WIMP properties. In addition, we detect more than 200 new background radio sources. Among them, we show there are two compelling candidates for being the radio counterpart of the possible γ-ray emission reported by other groups using Fermi-LAT data.

Dark matter in the Reticulum II dSph: a radio search

International Nuclear Information System (INIS)

Regis, Marco; Richter, Laura; Colafrancesco, Sergio

2017-01-01

We present a deep radio search in the Reticulum II dwarf spheroidal (dSph) galaxy performed with the Australia Telescope Compact Array. Observations were conducted at 16 cm wavelength, with an rms sensitivity of 0.01 mJy/beam, and with the goal of searching for synchrotron emission induced by annihilation or decay of weakly interacting massive particles (WIMPs). Data were complemented with observations on large angular scales taken with the KAT-7 telescope. We find no evidence for a diffuse emission from the dSph and we derive competitive bounds on the WIMP properties. In addition, we detect more than 200 new background radio sources. Among them, we show there are two compelling candidates for being the radio counterpart of the possible γ-ray emission reported by other groups using Fermi-LAT data.

THE SPECTRUM OF ISOTROPIC DIFFUSE GAMMA-RAY EMISSION BETWEEN 100 MeV AND 820 GeV

Energy Technology Data Exchange (ETDEWEB)

Ackermann, M.; Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Ajello, M. [Department of Physics and Astronomy, Clemson University, Kinard Lab of Physics, Clemson, SC 29634-0978 (United States); Albert, A.; Blandford, R. D.; Bloom, E. D.; Bottacini, E.; Caliandro, G. A. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Atwood, W. B. [Santa Cruz Institute for Particle Physics, Department of Physics and Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Baldini, L.; Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d' Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D.; Buson, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bechtol, K. [Kavli Institute for Cosmological Physics, University of Chicago, Chicago, IL 60637 (United States); Bissaldi, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, and Università di Trieste, I-34127 Trieste (Italy); Brandt, T. J. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Bregeon, J. [Laboratoire Univers et Particules de Montpellier, Université Montpellier 2, CNRS/IN2P3, F-34095 Montpellier (France); Bruel, P., E-mail: markus.ackermann@desy.de, E-mail: bechtol@kicp.uchicago.edu [Laboratoire Leprince-Ringuet, École Polytechnique, CNRS/IN2P3, F-91128 Palaiseau (France); and others

2015-01-20

The γ-ray sky can be decomposed into individually detected sources, diffuse emission attributed to the interactions of Galactic cosmic rays with gas and radiation fields, and a residual all-sky emission component commonly called the isotropic diffuse γ-ray background (IGRB). The IGRB comprises all extragalactic emissions too faint or too diffuse to be resolved in a given survey, as well as any residual Galactic foregrounds that are approximately isotropic. The first IGRB measurement with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope (Fermi) used 10 months of sky-survey data and considered an energy range between 200 MeV and 100 GeV. Improvements in event selection and characterization of cosmic-ray backgrounds, better understanding of the diffuse Galactic emission (DGE), and a longer data accumulation of 50 months allow for a refinement and extension of the IGRB measurement with the LAT, now covering the energy range from 100 MeV to 820 GeV. The IGRB spectrum shows a significant high-energy cutoff feature and can be well described over nearly four decades in energy by a power law with exponential cutoff having a spectral index of 2.32 ± 0.02 and a break energy of (279 ± 52) GeV using our baseline DGE model. The total intensity attributed to the IGRB is (7.2 ± 0.6) × 10{sup –6} cm{sup –2} s{sup –1} sr{sup –1} above 100 MeV, with an additional +15%/–30% systematic uncertainty due to the Galactic diffuse foregrounds.

Research and characterisation of blazar candidates among the Fermi/LAT 3FGL catalogue using multivariate classifications

Science.gov (United States)

Lefaucheur, Julien; Pita, Santiago

2017-06-01

Context. In the recently published 3FGL catalogue, the Fermi/LAT collaboration reports the detection of γ-ray emission from 3034 sources obtained after four years of observations. The nature of 1010 of those sources is unknown, whereas 2023 have well-identified counterparts in other wavelengths. Most of the associated sources are labelled as blazars (1717/2023), but the BL Lac or FSRQ nature of 573 of these blazars is still undetermined. Aims: The aim of this study was two-fold. First, to significantly increase the number of blazar candidates from a search among the large number of Fermi/LAT 3FGL unassociated sources (case A). Second, to determine the BL Lac or FSRQ nature of the blazar candidates, including those determined as such in this work and the blazar candidates of uncertain type (BCU) that are already present in the 3FGL catalogue (case B). Methods: For this purpose, multivariate classifiers - boosted decision trees and multilayer perceptron neural networks - were trained using samples of labelled sources with no caution flag from the 3FGL catalogue and carefully chosen discriminant parameters. The decisions of the classifiers were combined in order to obtain a high level of source identification along with well controlled numbers of expected false associations. Specifically for case A, dedicated classifications were generated for high (| b | >10◦) and low (| b | ≤10◦) galactic latitude sources; in addition, the application of classifiers to samples of sources with caution flag was considered separately, and specific performance metrics were estimated. Results: We obtained a sample of 595 blazar candidates (high and low galactic latitude) among the unassociated sources of the 3FGL catalogue. We also obtained a sample of 509 BL Lacs and 295 FSRQs from the blazar candidates cited above and the BCUs of the 3FGL catalogue. The number of expected false associations is given for different samples of candidates. It is, in particular, notably low ( 9

Estudo das latências e amplitudes dos potenciais evocados auditivos de média latência em indivíduos audiologicamente normais Middle latency response study of auditory evoked potentials’ amplitudes and lantencies audiologically normal individuals

Directory of Open Access Journals (Sweden)

Ivone Ferreira Neves

2007-02-01

Full Text Available Estudo de coorte contemporânea com corte transversal. O Potencial Evocado Auditivo de Média Latência (PEAML é gerado entre 10 e 80ms e possui múltiplos geradores, com maior contribuição da região tálamo-cortical. O estabelecimento de critérios de normalidade para os valores de latência e amplitude é necessário para uso clínico. OBJETIVOS: Analisar a latência e amplitude do PEAML em indivíduos sem alterações audiológicas, e verificar a confiabilidade da amplitude Pa-Nb. MATERIAL E MÉTODO: Foram coletados os PEAML de 25 indivíduos durante o ano de 2005 e analisados os componentes Na, Pa, Nb para cada orelha testada (A1 e A2, e posicionamento de eletrodo (C3 e C4. RESULTADOS: Observou-se diferença estatisticamente significante entre os valores médios de latência para C3A1 e C4A1 com relação aos componentes Na e Pa, não sendo encontrada esta diferença para o componente Nb e valores médios das amplitudes Na-Pa e Pa-Nb. CONCLUSÃO: Foram estabelecidos os valores das médias e desvios padrão para os parâmetros latência e amplitude dos componentes Na, Pa, Nb, e Na-Pa e Pa-Nb, nas condições C3A1, C4A1, C3A2, C4A2, proporcionando os parâmetros para a análise e interpretação deste potencial.Contemporary cohort cross-sectional study. Introduction: The auditory middle latency response (AMLR is generated between 10 and 80 ms and has multiple generators, with a greater contribution from the thalamus-cortical pathways. The establishment of normality criteria for latency and amplitude values is necessary for clinical use. AIM: to analyze the latency and amplitude of the AMLR in individuals without audiological disorders, and verify the reliability of Pa-Nb amplitude. MATERIALS AND METHODS: The AMLR of 25 individuals was collected during 2005 and the Na, Pa, Nb components were analyzed for each tested ear (A1 and A2, and electrode positioning (C3 and C4. RESULTS: A statistically significant difference was noticed among middle

NuSTAR reveals an intrinsically x-ray weak broad absorption line quasar in the ultraluminous infrared galaxy Markarian 231

DEFF Research Database (Denmark)

Teng, Stacy H.; Brandt, W. N.; Harrison, F. A.

2014-01-01

-ionization broad absorption line quasar that is intrinsically X-ray weak. The weak ionizing continuum may explain the lack of mid-infrared [O IV], [Ne V], and [Ne VI] fine-structure emission lines which are present in sources with otherwise similar AGN properties. We argue that the intrinsic X-ray weakness may...

An adaptive-binning method for generating constant-uncertainty/constant-significance light curves with Fermi-LAT data

International Nuclear Information System (INIS)

Lott, B.; Escande, L.; Larsson, S.; Ballet, J.

2012-01-01

Here, we present a method enabling the creation of constant-uncertainty/constant-significance light curves with the data of the Fermi-Large Area Telescope (LAT). The adaptive-binning method enables more information to be encapsulated within the light curve than with the fixed-binning method. Although primarily developed for blazar studies, it can be applied to any sources. Furthermore, this method allows the starting and ending times of each interval to be calculated in a simple and quick way during a first step. The reported mean flux and spectral index (assuming the spectrum is a power-law distribution) in the interval are calculated via the standard LAT analysis during a second step. In the absence of major caveats associated with this method Monte-Carlo simulations have been established. We present the performance of this method in determining duty cycles as well as power-density spectra relative to the traditional fixed-binning method.

EINSTEIN@HOME DISCOVERY OF FOUR YOUNG GAMMA-RAY PULSARS IN FERMI LAT DATA

Energy Technology Data Exchange (ETDEWEB)

Pletsch, H. J.; Allen, B.; Aulbert, C.; Bock, O.; Eggenstein, H. B.; Fehrmann, H.; Machenschalk, B.; Papa, M. A. [Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), D-30167 Hannover (Germany); Guillemot, L.; Champion, D. J.; Karuppusamy, R.; Kramer, M.; Ng, C. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Anderson, D. [Space Sciences Laboratory, University of California, Berkeley, CA 94720 (United States); Hammer, D.; Siemens, X. [Department of Physics, University of Wisconsin-Milwaukee, Milwaukee, WI 53201 (United States); Keith, M. [CSIRO Astronomy and Space Science, Australia Telescope National Facility (Australia); Ray, P. S., E-mail: holger.pletsch@aei.mpg.de, E-mail: lucas.guillemot@cnrs-orleans.fr [Space Science Division, Naval Research Laboratory, Washington, DC 20375-5352 (United States)

2013-12-10

We report the discovery of four gamma-ray pulsars, detected in computing-intensive blind searches of data from the Fermi Large Area Telescope (LAT). The pulsars were found using a novel search approach, combining volunteer distributed computing via Einstein@Home and methods originally developed in gravitational-wave astronomy. The pulsars PSRs J0554+3107, J1422–6138, J1522–5735, and J1932+1916 are young and energetic, with characteristic ages between 35 and 56 kyr and spin-down powers in the range 6 × 10{sup 34}—10{sup 36} erg s{sup –1}. They are located in the Galactic plane and have rotation rates of less than 10 Hz, among which the 2.1 Hz spin frequency of PSR J0554+3107 is the slowest of any known gamma-ray pulsar. For two of the new pulsars, we find supernova remnants coincident on the sky and discuss the plausibility of such associations. Deep radio follow-up observations found no pulsations, suggesting that all four pulsars are radio-quiet as viewed from Earth. These discoveries, the first gamma-ray pulsars found by volunteer computing, motivate continued blind pulsar searches of the many other unidentified LAT gamma-ray sources.

Characterization of weakly ionized argon flows for radio blackout mitigation experiments

Science.gov (United States)

Steffens, L.; Koch, U.; Esser, B.; Gülhan, A.

2017-06-01

For reproducing the so-called E × B communication blackout mitigation scheme inside the L2K arc heated facility of the DLR in weakly ionized argon §ows, a §at plate model has been equipped with a superconducting magnet, electrodes, and a setup comprising microwave plasma transmission spectroscopy (MPTS). A thorough characterization of the weakly ionized argon §ow has been performed including the use of microwave interferometry (MWI), Langmuir probe measurements, Pitot probe pro¦les, and spectroscopic methods like diode laser absorption spectroscopy (DLAS) and emission spectroscopy.

Study of the boxlike dark matter signals from dwarf spheroidal galaxies with Fermi-LAT data

Science.gov (United States)

Li, Shang; Liang, Yun-Feng; Xia, Zi-Qing; Zu, Lei; Duan, Kai-Kai; Shen, Zhao-Qiang; Feng, Lei; Yuan, Qiang; Fan, Yi-Zhong

2018-04-01

The observation of a special spectral feature in the gamma-ray data would be one of the best ways to identify dark matter (DM). The box-shaped gamma-ray spectra could be generated by the decay of intermediate particles produced by DM annihilation or decay. It provides another kind of signal that can be relatively easily distinguished from astrophysical backgrounds besides the linelike signals. Dwarf spheroidal galaxies are expected to be dominated by DM and may be one of the most promising targets for indirect DM searches. In this paper, we study the box-shaped DM signals with Fermi-LAT observations of dwarf spheroidal galaxies. We analyze 106 months of Fermi-LAT data to derive the upper limits on the annihilation cross section or the decay timescale of DM. In addition, we compare the results for different sample selections and DM density distributions. We expect that more dwarf spheroidal galaxies will be found and the sensitivity of box-shaped gamma-ray signal searches will be significantly improved in the future.

FERMI/LARGE AREA TELESCOPE DISCOVERY OF GAMMA-RAY EMISSION FROM THE FLAT-SPECTRUM RADIO QUASAR PKS 1454-354

International Nuclear Information System (INIS)

Abdo, A. A.; Ackermann, M.; Bechtol, K.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Brez, A.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Baughman, B. M.; Bogaert, G.; Bonamente, E.; Brigida, M.

2009-01-01

We report the discovery by the Large Area Telescope (LAT) onboard the Fermi Gamma-Ray Space Telescope of high-energy γ-ray (GeV) emission from the flat-spectrum radio quasar PKS 1454-354 (z = 1.424). On 2008 September 4, the source rose to a peak flux of (3.5 ± 0.7) x 10 -6 ph cm -2 s -1 (E > 100 MeV) on a timescale of hours and then slowly dropped over the following 2 days. No significant spectral changes occurred during the flare. Fermi/LAT observations also showed that PKS 1454-354 is the most probable counterpart of the unidentified EGRET source 3EG J1500-3509. Multiwavelength measurements performed during the following days (7 September with Swift; 6-7 September with the ground-based optical telescope Automated Telescope for Optical Monitoring; 13 September with the Australia Telescope Compact Array) resulted in radio, optical, UV, and X-ray fluxes greater than archival data, confirming the activity of PKS 1454-354.

The supernova remnant W49B as seen with H.E.S.S. and Fermi-LAT

Science.gov (United States)

H. E. S. S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Benkhali, F. Ait; Akhperjanian, A. G.; Andersson, T.; Angüner, E. O.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Tjus, J. Becker; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chalme-Calvet, R.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Cui, Y.; Davids, I. D.; Decock, J.; Degrange, B.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O.'C.; Dubus, G.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hadasch, D.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holler, M.; Horns, D.; Ivascenko, A.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kerszberg, D.; Khélifi, B.; Kieffer, M.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Naurois, M. de; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Öttl, S.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; los Reyes, R. de; Rieger, F.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; Eldik, C. van; Rensburg, C. van; Soelen, B. van; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.; Fermi-LAT Collaboration; Katsuta, J.

2018-04-01

The supernova remnant (SNR) W49B originated from a core-collapse supernova that occurred between one and four thousand years ago, and subsequently evolved into a mixed-morphology remnant, which is interacting with molecular clouds (MC). Gamma-ray observations of SNR-MC associations are a powerful tool to constrain the origin of Galactic cosmic rays, as they can probe the acceleration of hadrons through their interaction with the surrounding medium and subsequent emission of non-thermal photons. We report the detection of a γ-ray source coincident with W49B at very high energies (VHE; E > 100 GeV) with the H.E.S.S. Cherenkov telescopes together with a study of the source with five years of Fermi-LAT high-energy γ-ray (0.06-300 GeV) data. The smoothly connected, combined source spectrum, measured from 60 MeV to multi-TeV energies, shows two significant spectral breaks at 304 ± 20 MeV and 8.4-2.5+2.2 GeV; the latter is constrained by the joint fit from the two instruments. The detected spectral features are similar to those observed in several other SNR-MC associations and are found to be indicative of γ-ray emission produced through neutral-pion decay. The H.E.S.S. gamma-ray excess map (see Fig. 1, in FITS format) of the W49 region is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/612/A5

Whistler-triggered chorus emissions observed during daytime at low latitude ground station Jammu

Science.gov (United States)

Pratap Patel, Ravindra; Singh, K. K.; Singh, A. K.; Singh, R. P.

In this paper, we present whistler-triggered chorus emission recorded during daytime at low latitude ground station Jammu (geomag. Lat. = 22 degree 26 minute N; L = 1.17) during the period from 1996 to 2003. After analysis of the eight years collected data, we found out 29 events, which are definitely identified as chorus emission triggered by whistlers. During the observation period the magnetic activity is high. Analysis shows that the whistlers have propagated along the geomagnetic field line having L-values lying between L = 1.9 and 4.4. These waves could have propagated along the geomagnetic field lines either in ducted mode or pro-longitudinal mode. The measured relative intensity of the triggered emission and whistler wave is approximately the same and also varies from one event to another. It is proposed that these waves are generated through a process of wave-particle interaction and wave-wave interactions. Related parameters of this interaction are computed for different L-value and wave amplitude. With the help of dynamic spectra of these emissions, the proposed mechanisms are explained.

Fermi LAT Observation of Diffuse Gamma-Rays Produced through Interactions Between Local Interstellar Matter and High Energy Cosmic Rays

Energy Technology Data Exchange (ETDEWEB)

Abdo, A.A.; /Naval Research Lab, Wash., D.C. /Federal City Coll.; Ackermann, M.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Ajello, M.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Atwood, W.B.; /UC, Santa Cruz; Axelsson, M.; /Stockholm U. /Stockholm U., OKC; Baldini, L.; /INFN, Pisa; Ballet, J.; /DAPNIA, Saclay; Barbiellini, G.; /INFN, Trieste /Trieste U.; Bastieri, D.; /INFN, Padua /Padua U.; Baughman, B.M.; /Ohio State U.; Bechtol, K.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bellazzini, R.; /INFN, Pisa; Berenji, B.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bloom, E.D.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bonamente, E.; /INFN, Perugia /Perugia U.; Borgland, A.W.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bregeon, J.; /INFN, Pisa; Brez, A.; /INFN, Pisa; Brigida, M.; /Bari U. /INFN, Bari; Bruel, P.; /Ecole Polytechnique; Burnett, T.H.; /Washington U., Seattle /Bari U. /INFN, Bari /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /IASF, Milan /Milan Polytechnic /Royal Inst. Tech., Stockholm /Stockholm U., OKC /DAPNIA, Saclay /INFN, Perugia /Perugia U. /NASA, Goddard /Naval Research Lab, Wash., D.C. /George Mason U. /NASA, Goddard /INFN, Perugia /Perugia U. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Montpellier U. /Stockholm U. /Stockholm U., OKC /Royal Inst. Tech., Stockholm /ASDC, Frascati /Naval Research Lab, Wash., D.C. /INFN, Trieste /Bari U. /INFN, Bari /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /CENBG, Gradignan /CENBG, Gradignan /Montpellier U. /Bari U. /INFN, Bari /Ecole Polytechnique /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /INFN, Trieste /Hiroshima U. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Bari U. /INFN, Bari /INFN, Bari; /more authors..

2012-03-30

Observations by the Large Area Telescope (LAT) on the Fermi mission of diffuse {gamma}-rays in a mid-latitude region in the third quadrant (Galactic longitude l from 200{sup o} to 260{sup o} and latitude |b| from 22{sup o} to 60{sup o}) are reported. The region contains no known large molecular cloud and most of the atomic hydrogen is within 1 kpc of the solar system. The contributions of {gamma}-ray point sources and inverse Compton scattering are estimated and subtracted. The residual {gamma}-ray intensity exhibits a linear correlation with the atomic gas column density in energy from 100 MeV to 10 GeV. The measured integrated {gamma}-ray emissivity is (1.63 {+-} 0.05) x 10{sup -26} photons s{sup -1}sr{sup -1} H-atom{sup -1} and (0.66 {+-} 0.02) x 10{sup -26} photons s{sup -1}sr{sup -1} H-atom{sup -1} above 100 MeV and above 300 MeV, respectively, with an additional systematic error of {approx}10%. The differential emissivity from 100 MeV to 10 GeV agrees with calculations based on cosmic ray spectra consistent with those directly measured, at the 10% level. The results obtained indicate that cosmic ray nuclei spectra within 1 kpc from the solar system in regions studied are close to the local interstellar spectra inferred from direct measurements at the Earth within {approx}10%.

High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas

International Nuclear Information System (INIS)

Yanagisawa, Nobuyuki; Hana, Kiyomi; Nakada, Norihiro; Ichinoe, Masaaki; Koizumi, Wasaburo; Endou, Hitoshi; Okayasu, Isao; Murakumo, Yoshiki

2014-01-01

Oncocytic L-type amino acid transporter (LAT) 1 may be a prognostic indicator and target of new molecular therapeutic agents against malignancies. To investigate whether LAT1 expression influence the outcomes of patients with bile duct cancer, the expression of LAT1, LAT2, CD98, and Ki-67 was investigated immunohistochemically in 134 surgically resected bile duct adenocarcinomas, including 84 distal extrahepatic bile duct adenocarcinomas, 21 hilar cholangiocarcinomas, 15 intrahepatic cholangiocarcinomas, and 14 ampullary adenocarcinomas. LAT1 expression was weakly correlated with CD98 expression and Ki-67 labeling index (LI). Kaplan–Meier analysis showed a significant difference in prognosis between patients with bile duct adenocarcinomas having LAT1-high and -low scores, whereas LAT2 and CD98 expression and Ki-67 LI were not predictive of poor prognosis. Prognosis tended to be worse in patients having tumors with LAT1-high/LAT2-low than LAT1-low/LAT2-high scores (P = 0.0686). Multivariable analyses revealed that LAT1 expression, surgical margin, pT stage were independent prognostic factors. In conclusion, aberrant overexpression of LAT1 in bile duct adenocarcinoma predicts poor prognosis, suggesting that LAT1 may be a potential target of anticancer therapy

Search for very high-energy gamma-ray emission from the microquasar Cygnus X-1 with the MAGIC telescopes

Science.gov (United States)

Ahnen, M. L.; Ansoldi, S.; Antonelli, L. A.; Arcaro, C.; Babić, A.; Banerjee, B.; Bangale, P.; Barres de Almeida, U.; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bernardini, E.; Berti, A.; Bhattacharyya, W.; Biasuzzi, B.; Biland, A.; Blanch, O.; Bonnefoy, S.; Bonnoli, G.; Carosi, R.; Carosi, A.; Chatterjee, A.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; Cumani, P.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Lotto, B.; de Oña Wilhelmi, E.; di Pierro, F.; Doert, M.; Domínguez, A.; Dominis Prester, D.; Dorner, D.; Doro, M.; Einecke, S.; Eisenacher Glawion, D.; Elsaesser, D.; Engelkemeier, M.; Fallah Ramazani, V.; Fernández-Barral, A.; Fidalgo, D.; Fonseca, M. V.; Font, L.; Fruck, C.; Galindo, D.; García López, R. J.; Garczarczyk, M.; Gaug, M.; Giammaria, P.; Godinović, N.; Gora, D.; Guberman, D.; Hadasch, D.; Hahn, A.; Hassan, T.; Hayashida, M.; Herrera, J.; Hose, J.; Hrupec, D.; Ishio, K.; Konno, Y.; Kubo, H.; Kushida, J.; Kuveždić, D.; Lelas, D.; Lindfors, E.; Lombardi, S.; Longo, F.; López, M.; Maggio, C.; Majumdar, P.; Makariev, M.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menzel, U.; Minev, M.; Mirzoyan, R.; Moralejo, A.; Moreno, V.; Moretti, E.; Neustroev, V.; Niedzwiecki, A.; Nievas Rosillo, M.; Nilsson, K.; Ninci, D.; Nishijima, K.; Noda, K.; Nogués, L.; Paiano, S.; Palacio, J.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Paredes-Fortuny, X.; Pedaletti, G.; Peresano, M.; Perri, L.; Persic, M.; Prada Moroni, P. G.; Prandini, E.; Puljak, I.; Garcia, J. R.; Reichardt, I.; Rhode, W.; Ribó, M.; Rico, J.; Righi, C.; Saito, T.; Satalecka, K.; Schroeder, S.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Stamerra, A.; Strzys, M.; Surić, T.; Takalo, L.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Tescaro, D.; Teshima, M.; Torres, D. F.; Torres-Albà, N.; Treves, A.; Vanzo, G.; Vazquez Acosta, M.; Vovk, I.; Ward, J. E.; Will, M.; Zarić, D.; MAGIC Collaboration; Bosch-Ramon, V.; Pooley, G. G.; Trushkin, S. A.; Zanin, R.

2017-12-01

The microquasar Cygnus X-1 displays the two typical soft and hard X-ray states of a black hole transient. During the latter, Cygnus X-1 shows a one-sided relativistic radio-jet. Recent detection of the system in the high energy (HE; E ≳ 60 MeV) gamma-ray range with Fermi-LAT associates this emission with the outflow. Former MAGIC observations revealed a hint of flaring activity in the very high-energy (VHE; E ≳ 100 GeV) regime during this X-ray state. We analyse ∼97 h of Cygnus X-1 data taken with the MAGIC telescopes between July 2007 and October 2014. To shed light on the correlation between hard X-ray and VHE gamma rays as previously suggested, we study each main X-ray state separately. We perform an orbital phase-folded analysis to look for variability in the VHE band. Additionally, to place this variability behaviour in a multiwavelength context, we compare our results with Fermi-LAT, AGILE, Swift-BAT, MAXI, RXTE-ASM, AMI and RATAN-600 data. We do not detect Cygnus X-1 in the VHE regime. We establish upper limits for each X-ray state, assuming a power-law distribution with photon index Γ = 3.2. For steady emission in the hard and soft X-ray states, we set integral upper limits at 95 per cent confidence level for energies above 200 GeV at 2.6 × 10-12 photons cm-2 s-1 and 1.0 × 10-11 photons cm-2 s-1, respectively. We rule out steady VHE gamma-ray emission above this energy range, at the level of the MAGIC sensitivity, originating in the interaction between the relativistic jet and the surrounding medium, while the emission above this flux level produced inside the binary still remains a valid possibility.

Study on Influencing Factors of Carbon Emissions from Energy Consumption of Shandong Province of China from 1995 to 2012

Science.gov (United States)

Song, Jiekun; Song, Qing; Zhang, Dong; Lu, Youyou; Luan, Long

2014-01-01

Carbon emissions from energy consumption of Shandong province from 1995 to 2012 are calculated. Three zero-residual decomposition models (LMDI, MRCI and Shapley value models) are introduced for decomposing carbon emissions. Based on the results, Kendall coordination coefficient method is employed for testing their compatibility, and an optimal weighted combination decomposition model is constructed for improving the objectivity of decomposition. STIRPAT model is applied to evaluate the impact of each factor on carbon emissions. The results show that, using 1995 as the base year, the cumulative effects of population, per capita GDP, energy consumption intensity, and energy consumption structure of Shandong province in 2012 are positive, while the cumulative effect of industrial structure is negative. Per capita GDP is the largest driver of the increasing carbon emissions and has a great impact on carbon emissions; energy consumption intensity is a weak driver and has certain impact on carbon emissions; population plays a weak driving role, but it has the most significant impact on carbon emissions; energy consumption structure is a weak driver of the increasing carbon emissions and has a weak impact on carbon emissions; industrial structure has played a weak inhibitory role, and its impact on carbon emissions is great. PMID:24977216

Study on Influencing Factors of Carbon Emissions from Energy Consumption of Shandong Province of China from 1995 to 2012

Directory of Open Access Journals (Sweden)

Jiekun Song

2014-01-01

Full Text Available Carbon emissions from energy consumption of Shandong province from 1995 to 2012 are calculated. Three zero-residual decomposition models (LMDI, MRCI and Shapley value models are introduced for decomposing carbon emissions. Based on the results, Kendall coordination coefficient method is employed for testing their compatibility, and an optimal weighted combination decomposition model is constructed for improving the objectivity of decomposition. STIRPAT model is applied to evaluate the impact of each factor on carbon emissions. The results show that, using 1995 as the base year, the cumulative effects of population, per capita GDP, energy consumption intensity, and energy consumption structure of Shandong province in 2012 are positive, while the cumulative effect of industrial structure is negative. Per capita GDP is the largest driver of the increasing carbon emissions and has a great impact on carbon emissions; energy consumption intensity is a weak driver and has certain impact on carbon emissions; population plays a weak driving role, but it has the most significant impact on carbon emissions; energy consumption structure is a weak driver of the increasing carbon emissions and has a weak impact on carbon emissions; industrial structure has played a weak inhibitory role, and its impact on carbon emissions is great.

Anisotropies in the diffuse gamma-ray background measured by the Fermi-LAT

Energy Technology Data Exchange (ETDEWEB)

Cuoco, A. [Stockholm University-Oskar Klein Center AlbaNova University Center, Fysikum, SE-10691 Stockholm (Sweden); Linden, T. [Department of Physics, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Mazziotta, M.N. [Istituto Nazionale di Fisica Nucleare, Sezione di Bari, 70126 Bari (Italy); Siegal-Gaskins, J.M. [Einstein Postdoctoral Fellow, California Institute of Technology 1200 E. California Blvd., Pasadena, CA 91125 (United States); Vitale, Vincenzo, E-mail: vincenzo.vitale@roma2.infn.it [Istituto Nazionale di Fisica Nucleare, Sezione di Tor Vergata, 00133 Roma (Italy); Komatsu, E. [Texas Cosmology Center and Department of Astronomy, University of Texas, Austin, Dept. of Astronomy, 2511 Speedway, Austin, TX 78712 (United States)

2012-11-11

The small angular scale fluctuations of the (on large scale) isotropic gamma-ray background (IGRB) carry information about the presence of unresolved source classes. A guaranteed contribution to the IGRB is expected from the unresolved gamma-ray AGN while other extragalactic sources, Galactic gamma-ray source populations and dark matter Galactic and extragalactic structures (and sub-structures) are candidate contributors. The IGRB was measured with unprecedented precision by the Large Area Telescope (LAT) on-board of the Fermi gamma-ray observatory, and these data were used for measuring the IGRB angular power spectrum (APS). Detailed Monte Carlo simulations of Fermi-LAT all-sky observations were performed to provide a reference against which to compare the results obtained for the real data set. The Monte Carlo simulations are also a method for performing those detailed studies of the APS contributions of single source populations, which are required in order to identify the actual IGRB contributors. We present preliminary results of an anisotropy search in the IGRB. At angular scales <2 Degree-Sign (e.g., above multipole 155), angular power above the photon noise level is detected, at energies between 1 and 10 GeV in each energy bin, with statistical significance between 7.2 and 4.1{sigma}. The obtained energy dependences point to the presence of one or more unclustered source populations with the components having an average photon index {Gamma}=2.40{+-}0.07.

Fermi/LAT Observations of Swift/BAT Seyfert Galaxies: On the Contribution of Radio-Quiet Active Galactic Nuclei to the Extragalactic gamma-Ray Background

Science.gov (United States)

Teng, Stacy H.; Mushotzky, Richard F.; Sambruna, Rita M.; Davis, David S.; Reynolds, Christopher S.

2011-01-01

We present the analysis of 2.1 years of Fermi Large Area Telescope (LAT) data on 491 Seyfert galaxies detected by the Swift Burst Alert Telescope (BAT) survey. Only the two nearest objects, NGC 1068 and NGC 4945, which were identified in the Fermi first year catalog, are detected. Using Swift/BAT and radio 20 cm fluxes, we define a new radio-loudness parameter R(sub X,BAT) where radio-loud objects have logR(sub X,BAT) > -4.7. Based on this parameter, only radio-loud sources are detected by Fermi/LAT. An upper limit to the flux of the undetected sources is derived to be approx.2x10(exp -11) photons/sq cm/s, approximately seven times lower than the observed flux of NGC 1068. Assuming a median redshift of 0.031, this implies an upper limit to the gamma-ray (1-100 GeV) luminosity of BAT Seyfert galaxies with significant Fermi/LAT detections. A majority of these objects do not have Swift/BAT counterparts, but their possible optical counterparts include blazars, flat-spectrum radio quasars, and quasars.

Da Lat Nuclear Research Reactor. Role and perspective in the development of radioisotope and nuclear technique application in Vietnam

International Nuclear Information System (INIS)

Tran Ha Anh; Tran Khac An; Ngo Phu Khang; Nguyen Mong Sinh

1995-01-01

The Da Lat Nuclear Research Reactor is playing a central role in the development of both the Nuclear Research Institute and nuclear application in our country. Thanks to this main scientific tool, the Nuclear Research Institute nearly 10 years after the completion of its renovation from the previous American-made TRIGA MARK 2 reactor is being able to implement numerous scientific and technological research projects and to develop significant applications of radioisotopes and various nuclear techniques. A general overview of the research and development activities of the Institute based on the Da Lat Nuclear Research Reactor is given as well as those aiming at ensuring its safe, reliable and efficient operation and at enlarging the perspectives of its utilisation in the future. (authors). 5 refs., 1 fig., 1 tab

Fracture unicondylienne latérale sagittale du fémur associée à une ...

African Journals Online (AJOL)

Un patient de 24 ans a subit un traumatisme du genou droit suite à un accident de la voie publique occasionnant une fracture simultanée uni condylienne latérale et patellaire verticale. Cette association est exceptionnelle et aucun cas n'as été retrouvé dans la littérature .Un diagnostic précis clinique et radiologique suivi ...

Detergent-induced stabilization and improved 3D map of the human heteromeric amino acid transporter 4F2hc-LAT2.

Science.gov (United States)

Meury, Marcel; Costa, Meritxell; Harder, Daniel; Stauffer, Mirko; Jeckelmann, Jean-Marc; Brühlmann, Béla; Rosell, Albert; Ilgü, Hüseyin; Kovar, Karin; Palacín, Manuel; Fotiadis, Dimitrios

2014-01-01

Human heteromeric amino acid transporters (HATs) are membrane protein complexes that facilitate the transport of specific amino acids across cell membranes. Loss of function or overexpression of these transporters is implicated in several human diseases such as renal aminoacidurias and cancer. HATs are composed of two subunits, a heavy and a light subunit, that are covalently connected by a disulphide bridge. Light subunits catalyse amino acid transport and consist of twelve transmembrane α-helix domains. Heavy subunits are type II membrane N-glycoproteins with a large extracellular domain and are involved in the trafficking of the complex to the plasma membrane. Structural information on HATs is scarce because of the difficulty in heterologous overexpression. Recently, we had a major breakthrough with the overexpression of a recombinant HAT, 4F2hc-LAT2, in the methylotrophic yeast Pichia pastoris. Microgram amounts of purified protein made possible the reconstruction of the first 3D map of a human HAT by negative-stain transmission electron microscopy. Here we report the important stabilization of purified human 4F2hc-LAT2 using a combination of two detergents, i.e., n-dodecyl-β-D-maltopyranoside and lauryl maltose neopentyl glycol, and cholesteryl hemisuccinate. The superior quality and stability of purified 4F2hc-LAT2 allowed the measurement of substrate binding by scintillation proximity assay. In addition, an improved 3D map of this HAT could be obtained. The detergent-induced stabilization of the purified human 4F2hc-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution, and thus the elucidation of the working mechanism of this important protein complex at the molecular level.

Detergent-induced stabilization and improved 3D map of the human heteromeric amino acid transporter 4F2hc-LAT2.

Directory of Open Access Journals (Sweden)

Marcel Meury

Full Text Available Human heteromeric amino acid transporters (HATs are membrane protein complexes that facilitate the transport of specific amino acids across cell membranes. Loss of function or overexpression of these transporters is implicated in several human diseases such as renal aminoacidurias and cancer. HATs are composed of two subunits, a heavy and a light subunit, that are covalently connected by a disulphide bridge. Light subunits catalyse amino acid transport and consist of twelve transmembrane α-helix domains. Heavy subunits are type II membrane N-glycoproteins with a large extracellular domain and are involved in the trafficking of the complex to the plasma membrane. Structural information on HATs is scarce because of the difficulty in heterologous overexpression. Recently, we had a major breakthrough with the overexpression of a recombinant HAT, 4F2hc-LAT2, in the methylotrophic yeast Pichia pastoris. Microgram amounts of purified protein made possible the reconstruction of the first 3D map of a human HAT by negative-stain transmission electron microscopy. Here we report the important stabilization of purified human 4F2hc-LAT2 using a combination of two detergents, i.e., n-dodecyl-β-D-maltopyranoside and lauryl maltose neopentyl glycol, and cholesteryl hemisuccinate. The superior quality and stability of purified 4F2hc-LAT2 allowed the measurement of substrate binding by scintillation proximity assay. In addition, an improved 3D map of this HAT could be obtained. The detergent-induced stabilization of the purified human 4F2hc-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution, and thus the elucidation of the working mechanism of this important protein complex at the molecular level.

DISCOVERY OF PULSED γ-RAYS FROM PSR J0034-0534 WITH THE FERMI LARGE AREA TELESCOPE: A CASE FOR CO-LOCATED RADIO AND γ-RAY EMISSION REGIONS

International Nuclear Information System (INIS)

Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Bechtol, K.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Bouvier, A.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Brez, A.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bonamente, E.; Brigida, M.; Bruel, P.

2010-01-01

Millisecond pulsars (MSPs) have been firmly established as a class of γ-ray emitters via the detection of pulsations above 0.1 GeV from eight MSPs by the Fermi Large Area Telescope (LAT). Using 13 months of LAT data, significant γ-ray pulsations at the radio period have been detected from the MSP PSR J0034-0534, making it the ninth clear MSP detection by the LAT. The γ-ray light curve shows two peaks separated by 0.274 ± 0.015 in phase which are very nearly aligned with the radio peaks, a phenomenon seen only in the Crab pulsar until now. The ≥0.1 GeV spectrum of this pulsar is well fit by an exponentially cutoff power law with a cutoff energy of 1.8 ± 0.6 ± 0.1 GeV and a photon index of 1.5 ± 0.2 ± 0.1, first errors are statistical and second are systematic. The near-alignment of the radio and γ-ray peaks strongly suggests that the radio and γ-ray emission regions are co-located and both are the result of caustic formation.

Gamma-Ray Flaring Activity from the Gravitationally Lensed Blazar PKS 1830-211 Observed by Fermi LAT

Energy Technology Data Exchange (ETDEWEB)

Abdo, A. A.; et al.

2015-01-23

The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the MeV-peaked flat-spectrum radio quasar PKS 1830–211 (z = 2.507). Its apparent isotropic γ-ray luminosity (E > 100 MeV), averaged over ~3 years of observations and peaking on 2010 October 14/15 at 2.9 × 10(50) erg s(–)(1), makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time-delayed variability to follow about 25 days after a primary flare, with flux about a factor of 1.5 less. Two large γ-ray flares of PKS 1830–211 have been detected by the LAT in the considered period, and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the γ-ray flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program indicate a hard spectrum with no significant correlation of X-ray flux with the γ-ray variability. The spectral energy distribution can be modeled with inverse Compton scattering of thermal photons from the dusty torus. The implications of the LAT data in terms of variability, the lack of evident delayed flare events, and different radio and γ-ray flux ratios are discussed. Microlensing effects, absorption, size and location of the emitting regions, the complex mass distribution of the system, an energy-dependent inner structure of the source, and flux suppression by the lens galaxy for one image path may be considered as hypotheses for understanding our results.

FERMI OBSERVATIONS OF HIGH-ENERGY GAMMA-RAY EMISSION FROM GRB 080825C

International Nuclear Information System (INIS)

Abdo, A. A.; Ackermann, M.; Bechtol, K.; Berenji, B.; Bloom, E. D.; Borgland, A. W.; Bouvier, A.; Asano, K.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Ballet, J.; Band, D. L.; Barbiellini, G.; Bastieri, D.; Bhat, P. N.; Bissaldi, E.; Bonamente, E.

2009-01-01

The Fermi Gamma-ray Space Telescope has opened a new high-energy window in the study of gamma-ray bursts (GRBs). Here we present a thorough analysis of GRB 080825C, which triggered the Fermi Gamma-ray Burst Monitor (GBM), and was the first firm detection of a GRB by the Fermi Large Area Telescope (LAT). We discuss the LAT event selections, background estimation, significance calculations, and localization for Fermi GRBs in general and GRB 080825C in particular. We show the results of temporal and time-resolved spectral analysis of the GBM and LAT data. We also present some theoretical interpretation of GRB 080825C observations as well as some common features observed in other LAT GRBs.

On the Weak-Wind Problem in Massive Stars: X-Ray Spectra Reveal a Massive Hot Wind in mu Columbae

Science.gov (United States)

Huenemoerder, David P.; Oskinova, Lidia M.; Ignace, Richard; Waldron, Wayne L.; Todt, Helge; Hamaguchi, Kenji; Kitamoto, Shunji

2012-01-01

Mu Columbae is a prototypical weak-wind O star for which we have obtained a high-resolution X-ray spectrum with the Chandra LETG/ACIS instrument and a low-resolution spectrum with Suzaku. This allows us, for the first time, to investigate the role of X-rays on the wind structure in a bona fide weak-wind system and to determine whether there actually is a massive hot wind. The X-ray emission measure indicates that the outflow is an order of magnitude greater than that derived from UV lines and is commensurate with the nominal wind-luminosity relationship for O stars. Therefore, the "weak-wind problem"--identified from cool wind UV/optical spectra--is largely resolved by accounting for the hot wind seen in X-rays. From X-ray line profiles, Doppler shifts, and relative strengths, we find that this weak-wind star is typical of other late O dwarfs. The X-ray spectra do not suggest a magnetically confined plasma-the spectrum is soft and lines are broadened; Suzaku spectra confirm the lack of emission above 2 keV. Nor do the relative line shifts and widths suggest any wind decoupling by ions. The He-like triplets indicate that the bulk of the X-ray emission is formed rather close to the star, within five stellar radii. Our results challenge the idea that some OB stars are "weak-wind" stars that deviate from the standard wind-luminosity relationship. The wind is not weak, but it is hot and its bulk is only detectable in X-rays.

Fermi-LAT γ-ray anisotropy and intensity explained by unresolved radio-loud active galactic nuclei

International Nuclear Information System (INIS)

Mauro, Mattia Di; Cuoco, Alessandro; Donato, Fiorenza; Siegal-Gaskins, Jennifer M.

2014-01-01

Radio-loud active galactic nuclei (AGN) are expected to contribute substantially to both the intensity and anisotropy of the isotropic γ-ray background (IGRB). In turn, the measured properties of the IGRB can be used to constrain the characteristics of proposed contributing source classes. We consider individual subclasses of radio-loud AGN, including low-, intermediate-, and high-synchrotron-peaked BL Lacertae objects, flat-spectrum radio quasars, and misaligned AGN. Using updated models of the γ-ray luminosity functions of these populations, we evaluate the energy-dependent contribution of each source class to the intensity and anisotropy of the IGRB. We find that collectively radio-loud AGN can account for the entirety of the IGRB intensity and anisotropy as measured by the Fermi Large Area Telescope (LAT). Misaligned AGN provide the bulk of the measured intensity but a negligible contribution to the anisotropy, while high-synchrotron-peaked BL Lacertae objects provide the dominant contribution to the anisotropy. In anticipation of upcoming measurements with the Fermi-LAT and the forthcoming Cherenkov Telescope Array, we predict the anisotropy in the broader energy range that will be accessible to future observations

Fermi-LAT γ-ray anisotropy and intensity explained by unresolved radio-loud active galactic nuclei

Energy Technology Data Exchange (ETDEWEB)

Mauro, Mattia Di; Cuoco, Alessandro; Donato, Fiorenza [Dipartimento di Fisica, Università di Torino, via P. Giuria 1, Torino, 10125 Italy (Italy); Siegal-Gaskins, Jennifer M., E-mail: mattia.dimauro@to.infn.it, E-mail: alessandro.cuoco@to.infn.it, E-mail: donato@to.infn.it, E-mail: jsg@tapir.caltech.edu [California Institute of Technology, 1200 E. California Blvd., Pasadena, CA, 91125 (United States)

2014-11-01

Radio-loud active galactic nuclei (AGN) are expected to contribute substantially to both the intensity and anisotropy of the isotropic γ-ray background (IGRB). In turn, the measured properties of the IGRB can be used to constrain the characteristics of proposed contributing source classes. We consider individual subclasses of radio-loud AGN, including low-, intermediate-, and high-synchrotron-peaked BL Lacertae objects, flat-spectrum radio quasars, and misaligned AGN. Using updated models of the γ-ray luminosity functions of these populations, we evaluate the energy-dependent contribution of each source class to the intensity and anisotropy of the IGRB. We find that collectively radio-loud AGN can account for the entirety of the IGRB intensity and anisotropy as measured by the Fermi Large Area Telescope (LAT). Misaligned AGN provide the bulk of the measured intensity but a negligible contribution to the anisotropy, while high-synchrotron-peaked BL Lacertae objects provide the dominant contribution to the anisotropy. In anticipation of upcoming measurements with the Fermi-LAT and the forthcoming Cherenkov Telescope Array, we predict the anisotropy in the broader energy range that will be accessible to future observations.

Weak measurements and quantum weak values for NOON states

Science.gov (United States)

Rosales-Zárate, L.; Opanchuk, B.; Reid, M. D.

2018-03-01

Quantum weak values arise when the mean outcome of a weak measurement made on certain preselected and postselected quantum systems goes beyond the eigenvalue range for a quantum observable. Here, we propose how to determine quantum weak values for superpositions of states with a macroscopically or mesoscopically distinct mode number, that might be realized as two-mode Bose-Einstein condensate or photonic NOON states. Specifically, we give a model for a weak measurement of the Schwinger spin of a two-mode NOON state, for arbitrary N . The weak measurement arises from a nondestructive measurement of the two-mode occupation number difference, which for atomic NOON states might be realized via phase contrast imaging and the ac Stark effect using an optical meter prepared in a coherent state. The meter-system coupling results in an entangled cat-state. By subsequently evolving the system under the action of a nonlinear Josephson Hamiltonian, we show how postselection leads to quantum weak values, for arbitrary N . Since the weak measurement can be shown to be minimally invasive, the weak values provide a useful strategy for a Leggett-Garg test of N -scopic realism.

On the observations of unique low latitude whistler-triggered VLF/ELF emissions

Science.gov (United States)

Altaf, M.; Singh, K. K.; Singh, A. K.; Lalmani

A detailed analysis of the VLF/ELF wave data obtained during a whistler campaign under All India Coordinated Program of Ionosphere Thermosphere Studies (AICPITS) at our low latitude Indian ground station Jammu (geomag. lat. = 22° 26‧ N, L = 1.17) has yielded two types of unusual and unique whistler-triggered VLF/ELF emissions. These include (1) whistler-triggered hook emissions and (2) whistler-triggered long enduring discrete chorus riser emissions in VLF/ELF frequency range during night time. Such types of whistler-triggered emissions have not been reported earlier from any of the ground observations at low latitudes. In the present study, the observed characteristics of these emissions are described and interpreted. Dispersion analysis of these emissions show that the whistlers as well as emissions have propagated along a higher geomagnetic field line path with L-values lying ∼L = 4, suggesting that these triggered emissions are to be regarded as mid-latitude emissions. These waves could have propagated along the geomagnetic field lines either in a ducted mode or in a pro-longitudinal (PL) mode. The measured intensity of the triggered emissions is almost equal to that of the source waves and does not vary throughout the period of observation on that day. It is speculated that these emissions may have been generated through a process of resonant interaction of the whistler waves with energetic electrons. Parameters related to this interaction are computed for different values of L and wave amplitude. The proposed mechanism explains some aspects of the dynamic spectra.

Weak hard X-ray emission from two broad absorption line quasars observed with NuSTAR: Compton-thick absorption or intrinsic X-ray weakness?

DEFF Research Database (Denmark)

Luo, B.; Brandt, W. N.; Alexander, D. M.

2013-01-01

are not significantly absorbed (NH ≲ 1024 cm-2). However, both BAL quasars are only detected in the softer NuSTAR bands (e.g., 4-20 keV) but not in its harder bands (e.g., 20-30 keV), suggesting that either the shielding gas is highly Compton-thick or the two targets are intrinsically X-ray weak. We constrain...... likely explanation. We also discuss the intrinsic X-ray weakness scenario based on a coronal-quenching model relevant to the shielding gas and disk wind of BAL quasars. Motivated by our NuSTAR results, we perform a Chandra stacking analysis with the Large Bright Quasar Survey BAL quasar sample and place...

Search for Gamma-Ray Emission from DES Dwarf Spheroidal Galaxy Candidates with Fermi-LAT Data

Energy Technology Data Exchange (ETDEWEB)

Drlica-Wagner, A.; et al.

2015-08-04

Due to their proximity, high dark-matter (DM) content, and apparent absence of non-thermal processes, Milky Way dwarf spheroidal satellite galaxies (dSphs) are excellent targets for the indirect detection of DM. Recently, eight new dSph candidates were discovered using the first year of data from the Dark Energy Survey (DES). We searched for gamma-ray emission coincident with the positions of these new objects in six years of Fermi Large Area Telescope data. We found no significant excesses of gamma-ray emission. Under the assumption that the DES candidates are dSphs with DM halo properties similar to the known dSphs, we computed individual and combined limits on the velocity-averaged DM annihilation cross section for these new targets. If the estimated DM content of these dSph candidates is confirmed, they will constrain the annihilation cross section to lie below the thermal relic cross section for DM particles with masses $\\lesssim 20\\,\\mathrm{GeV}$ annihilating via the $b\\bar{b}$ or τ(+)τ(-) channels.

Discovery of γ-ray Emission from the Strongly Lobe-dominated Quasar 3C 275.1

Science.gov (United States)

Liao, Neng-Hui; Xin, Yu-Liang; Li, Shang; Jiang, Wei; Liang, Yun-Feng; Li, Xiang; Zhang, Peng-Fei; Chen, Liang; Bai, Jin-Ming; Fan, Yi-Zhong

2015-07-01

We systematically analyze the 6 year Fermi/Large Area Telescope (LAT) data on lobe-dominated quasars (LDQs) in the complete LDQ sample from the Revised third Cambridge Catalogue of Radio Sources (3CRR) survey and report the discovery of high-energy γ-ray emission from 3C 275.1. The γ-ray emission of 3C 207 is confirmed and significant variability of the light curve is identified. We do not find statistically significant γ-ray emission from other LDQs. 3C 275.1 is the known γ-ray quasar with the lowest core dominance parameter (i.e., R = 0.11). We also show that both the northern radio hotspot and parsec jet models can reasonably reproduce the γ-ray data. The parsec jet model, however, is favored by the potential γ-ray variability on a timescale of months. We suggest that some dimmer γ-ray LDQs will be detected in the future and LDQs could contribute non-ignorably to the extragalactic γ-ray background.

TOMS/Earth Probe UV Reflectivity Daily L3 Global 1x1.25 deg Lat/Lon Grid V008

Data.gov (United States)

National Aeronautics and Space Administration — This data product contains TOMS/Earth Probe UV Reflectivity Daily L3 Global 1x1.25 deg Lat/Lon Grid Version 8 data in ASCII format. (The shortname for this Level-3...

Investigation of mechanisms for He-I emission radial profile broadening in a weakly ionized cylindrical helium plasma with recombining edge

Energy Technology Data Exchange (ETDEWEB)

Hollmann, E. M.; Brandt, C.; Hudson, B.; Nishijima, D.; Pigarov, A. Yu. [University of California–San Diego, 9500 Gilman Dr., La Jolla, California 92093-0417 (United States); Kumar, D. [Johns Hopkins University, 3400 N Charles St., Baltimore, Maryland 21218 (United States)

2013-09-15

Spatially resolved spectroscopic measurements of He-I line emission are used to study the causes of emission profile broadening radially across the cylinder of a weakly ionized helium plasma. The plasma consists of an ionizing core (r < 2 cm) surrounded by a recombining edge (r > 2 cm) plasma. The brightness profiles of low-n EUV He-I resonance lines are shown to be strongly radially broadened due to opacity. The brightness profiles of high-n visible lines are also found to be strongly radially broadened, but dominantly due to edge recombination. Visible low-n lines are less strongly radially broadened, apparently by a combination of both recombination and EUV opacity. The low-n visible He-I line ratio method with central opacity correction is found to calculate central electron density and temperature well, with poor agreement at the edge, as expected for recombining plasma. In the recombining edge, high-n Boltzmann analysis is found to accurately measure the cold (T{sub e} < 0.2 eV) edge temperature. Near the core, however, high-n Boltzmann analysis can be complicated by electron-impact excitation, giving incorrect (T{sub e}≈ 0.1 eV) apparent temperatures. Probe measurements were not able to capture the cold edge temperature accurately, probably due to large potential fluctuations, even when using fast triple probe measurements. Fast spectroscopic measurements show that this discrepancy is not explained by recombining plasma alternating with ionizing plasma in the edge region.

{sup 18}F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with {sup 18}F-FDG and {sup 11}C-Methionine PET

Energy Technology Data Exchange (ETDEWEB)

Watabe, Tadashi [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan); Osaka University Graduate School of Medicine, PET Molecular Imaging Center, Osaka (Japan); Ikeda, Hayato; Aoki, Masanao [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan); Nagamori, Shushi; Wiriyasermkul, Pattama; Tanaka, Yoko; Hagiwara, Kohei; Kanai, Yoshikatsu [Osaka University Graduate School of Medicine, Department of Bio-system Pharmacology, Osaka (Japan); Naka, Sadahiro [Osaka University, Osaka University Graduate School of Medicine, Osaka University Hospital, Osaka (Japan); Kanai, Yasukazu [Osaka University Graduate School of Medicine, PET Molecular Imaging Center, Osaka (Japan); Osaka University Graduate School of Medicine, Department of Molecular Imaging in Medicine, Osaka (Japan); Shimosegawa, Eku [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan); Osaka University Graduate School of Medicine, PET Molecular Imaging Center, Osaka (Japan); Osaka University, Osaka University Graduate School of Medicine, Osaka University Hospital, Osaka (Japan); Hatazawa, Jun [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan); Osaka University Graduate School of Medicine, PET Molecular Imaging Center, Osaka (Japan); Osaka University, Immunology Frontier Research Center, Osaka (Japan)

2017-02-15

The purpose of this study was to evaluate the usefulness of L-4-borono-2-{sup 18}F-fluoro-phenylalanine ({sup 18}F-FBPA) as a tumor-specific probe, in comparison to {sup 18}F-FDG and {sup 11}C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. Cellular analyses of FBPA were performed to evaluate the transportability and K{sub m} value. PET studies were performed in rat xenograft models of C6 glioma (n = 12) and in rat models of turpentine oil-induced subcutaneous inflammation (n = 9). The kinetic parameters and uptake values on static PET images were compared using the one-tissue compartment model (K{sub 1}, k{sub 2}) and maximum standardized uptake value (SUVmax). The cellular analyses showed that FBPA had a lower affinity to a normal cell-type transporter LAT2 and induced less efflux through LAT2 among FBPA, Met, and BPA, while the efflux through LAT1 induced by FBPA was similar among the three compounds. The K{sub m} value of {sup 18}F-FBPA for LAT1 (196.8 ± 11.4 μM) was dramatically lower than that for LAT2 (2813.8 ± 574.5 μM), suggesting the higher selectivity of {sup 18}F-FBPA for LAT1. K{sub 1} and k{sub 2} values were significantly smaller in {sup 18}F-FBPA PET (K{sub 1} = 0.04 ± 0.01 ml/ccm/min and k{sub 2} = 0.07 ± 0.01 /min) as compared to {sup 11}C-Met PET (0.22 ± 0.09 and 0.52 ± 0.10, respectively) in inflammatory lesions. Static PET analysis based on the SUVmax showed significantly higher accumulation of {sup 18}F-FDG in the tumor and inflammatory lesions (7.2 ± 2.1 and 4.6 ± 0.63, respectively) as compared to both {sup 18}F-FBPA (3.2 ± 0.40 and 1.9 ± 0.19) and {sup 11}C-Met (3.4 ± 0.43 and 1.6 ± 0.11). No significant difference was observed between {sup 18}F-FBPA and {sup 11}C-Met in the static PET images. This study shows the utility of {sup 18}F-FBPA as a tumor-specific probe of LAT1 with low accumulation in the inflammatory lesions. (orig.)

"1"8F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with "1"8F-FDG and "1"1C-Methionine PET

International Nuclear Information System (INIS)

Watabe, Tadashi; Ikeda, Hayato; Aoki, Masanao; Nagamori, Shushi; Wiriyasermkul, Pattama; Tanaka, Yoko; Hagiwara, Kohei; Kanai, Yoshikatsu; Naka, Sadahiro; Kanai, Yasukazu; Shimosegawa, Eku; Hatazawa, Jun

2017-01-01

The purpose of this study was to evaluate the usefulness of L-4-borono-2-"1"8F-fluoro-phenylalanine ("1"8F-FBPA) as a tumor-specific probe, in comparison to "1"8F-FDG and "1"1C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. Cellular analyses of FBPA were performed to evaluate the transportability and K_m value. PET studies were performed in rat xenograft models of C6 glioma (n = 12) and in rat models of turpentine oil-induced subcutaneous inflammation (n = 9). The kinetic parameters and uptake values on static PET images were compared using the one-tissue compartment model (K_1, k_2) and maximum standardized uptake value (SUVmax). The cellular analyses showed that FBPA had a lower affinity to a normal cell-type transporter LAT2 and induced less efflux through LAT2 among FBPA, Met, and BPA, while the efflux through LAT1 induced by FBPA was similar among the three compounds. The K_m value of "1"8F-FBPA for LAT1 (196.8 ± 11.4 μM) was dramatically lower than that for LAT2 (2813.8 ± 574.5 μM), suggesting the higher selectivity of "1"8F-FBPA for LAT1. K_1 and k_2 values were significantly smaller in "1"8F-FBPA PET (K_1 = 0.04 ± 0.01 ml/ccm/min and k_2 = 0.07 ± 0.01 /min) as compared to "1"1C-Met PET (0.22 ± 0.09 and 0.52 ± 0.10, respectively) in inflammatory lesions. Static PET analysis based on the SUVmax showed significantly higher accumulation of "1"8F-FDG in the tumor and inflammatory lesions (7.2 ± 2.1 and 4.6 ± 0.63, respectively) as compared to both "1"8F-FBPA (3.2 ± 0.40 and 1.9 ± 0.19) and "1"1C-Met (3.4 ± 0.43 and 1.6 ± 0.11). No significant difference was observed between "1"8F-FBPA and "1"1C-Met in the static PET images. This study shows the utility of "1"8F-FBPA as a tumor-specific probe of LAT1 with low accumulation in the inflammatory lesions. (orig.)

Three Millisecond Pulsars in Fermi LAT Unassociated Bright Sources

Science.gov (United States)

Ransom, S. M.; Ray, P. S.; Camilo, F.; Roberts, M. S. E.; Celik, O.; Wolff, M. T.; Cheung, C. C.; Kerr, M.; Pennucci, T.; DeCesar, M. E.;

New Theoretical Estimates of the Contribution of Unresolved Star-Forming Galaxies to the Extragalactic Gamma-Ray Background (EGB) as Measured by EGRET and the Fermi-LAT

Science.gov (United States)

Venters, Tonia M.

2011-01-01

We present new theoretical estimates of the contribution of unresolved star-forming galaxies to the extragalactic gamma-ray background (EGB) as measured by EGRET and the Fermi-LAT. We employ several methods for determining the star-forming galaxy contribution the the EGB, including a method positing a correlation between the gamma-ray luminosity of a galaxy and its rate of star formation as calculated from the total infrared luminosity, and a method that makes use of a model of the evolution of the galaxy gas mass with cosmic time. We find that depending on the model, unresolved star-forming galaxies could contribute significantly to the EGB as measured by the Fermi-LAT at energies between approx. 300 MeV and approx. few GeV. However, the overall spectrum of unresolved star-forming galaxies can explain neither the EGRET EGB spectrum at energies between 50 and 200 MeV nor the Fermi-LAT EGB spectrum at energies above approx. few GeV.

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function

Czech Academy of Sciences Publication Activity Database

Wang, Y.; Horváth, Ondřej; Hamm-Baarke, A.; Richelme, M.; Grégoire, C.; Guinamard, R.; Hořejší, Václav; Angelisová, Pavla; Špička, Jiří; Schraven, B.; Malissen, B.; Malissen, M.

2005-01-01

Roč. 25, č. 11 (2005), s. 4455-4465 ISSN 0270-7306 R&D Projects: GA MŠk(CZ) 1M0506 Institutional research plan: CEZ:AV0Z50520514 Keywords : NTAL * LAT * B-cell Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 7.093, year: 2005

The coal question that emissions trading has not answered

International Nuclear Information System (INIS)

Pearse, Rebecca

2016-01-01

Can emissions trading assist with the task of placing a limit on coal production and consumption in Australia? This paper outlines a critical political economy perspective on coal and a flagship ‘market mechanism’ for emissions reduction. The prospects for an effective emissions trading scheme in coal-dominated economies are considered in light of its theoretical justifications as well as recent attempts to price carbon in Australia. Emissions trading is a weak instrument that does not address real-world failures of coal governance. At their theoretical best, carbon prices produce marginal changes to the cost structure of production. In practice, the Australian case demonstrates emissions trading is an attempt to displace the emissions reduction task away from coal, through compensation arrangements and offsetting. In light of the urgent need to rapidly reduce global emissions, direct regulation and democratisation of coal production and consumption should be flagship climate policy. - Highlights: • Emissions trading schemes (ETS) are weak instruments for placing a limit on coal. • Pre-existing failures of coal governance cannot be addressed by emissions trading. • Considerable transfers of public wealth to coal companies occurred as part of the Australian ETS. • Carbon offset arrangements spatially displace responsibility for reducing emissions away from coal.

Limiar e latência do reflexo acústico sob efeito de estimulação contralateral Threshold and latency of acoustic reflex under effect of contralateral noise

Directory of Open Access Journals (Sweden)

Isabella Elias Burjato Raposo do Amaral

2008-03-01

Full Text Available OBJETIVO: Investigar o efeito inibitório da via eferente auditiva na variação do limiar e da latência do reflexo acústico ipsilateral com estimulação contralateral. MÉTODOS: Foram avaliados 17 pacientes entre 18 e 30 anos, com audição dentro dos padrões de normalidade submetidos à pesquisa de limiar e de latência do reflexo acústico, com e sem estimulação contralateral. RESULTADOS: Foram observadas médias de latência sem ruído contralateral para as freqüências de 500, 1000 e 2000 Hz respectivamente em 234,48, 214,96 e 236,71 milissegundos. Os valores de latência com ruído nas mesmas freqüências foram 230,74, 214,00 e 232,15 milissegundos. CONCLUSÃO: Houve diminuição da latência e aumento dos limiares do reflexo acústico quando apresentado estímulo supressor na orelha contralateral.PURPOSE: To investigate the inhibitory effect of the efferent auditory path in the variation of the threshold and the latency of ipsilateral acoustic reflex with contralateral stimulation. METHODS: Seventeen male and female patients, with ages between 18 and 30 years and with average normal hearing, were evaluated. After verification of inclusion criteria, the subjects were submitted to acoustic reflex threshold and latency testings, with and without contralateral masking. RESULTS: The latency average rates without contralateral noise at the frequencies 500 Hz, 1000 Hz and 2000 Hz were, respectively, 234,48, 214,96 and 236,71 milliseconds. The latency rates with noise at the same frequencies were 230,74, 214,00 and 232,15 milliseconds. CONCLUSION: The results showed latency decrease and increase on the acoustic reflex thresholds with contralateral white noise suppressor stimulus.

The DTU15 MSS (Mean Sea Surface) and DTU15LAT (Lowest Astronomical Tide) reference surface

DEFF Research Database (Denmark)

Andersen, Ole Baltazar; Stenseng, Lars; Piccioni, Gaia

in the Arctic Ocean for DTU10MSS and DTU13MSS.A new reference surface for off-shore vertical referencing is introduced. This is called the DTU15LAT.The surface is derived from the DTU15MSS and the DTU10 Global ocean tide to give a 19 year Lowest Astronomical Tide referenced to either the Mean sea surface...

EIGHT γ-RAY PULSARS DISCOVERED IN BLIND FREQUENCY SEARCHES OF FERMI LAT DATA

International Nuclear Information System (INIS)

Saz Parkinson, P. M.; Dormody, M.; Ziegler, M.; Belfiore, A.; Johnson, R. P.; Ray, P. S.; Abdo, A. A.; Grove, J. E.; Gwon, C.; Ballet, J.; Baring, M. G.; Burnett, T. H.; Caliandro, G. A.; Camilo, F.; Caraveo, P. A.; De Luca, A.; Ferrara, E. C.; Harding, A. K.; Johnson, T. J.; Freire, P. C. C.

2010-01-01

We report the discovery of eight γ-ray pulsars in blind frequency searches of ∼650 source positions using the Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope. We present the timing models, light curves, and detailed spectral parameters of the new pulsars. PSRs J1023-5746, J1044-5737, J1413-5205, J1429-5911, and J1954+2836 are young (τ c 10 36 erg s -1 ), and located within the Galactic plane (|b| 0 ). The remaining three pulsars, PSRs J1846+0919, J1957+5033, and J2055+25, are less energetic, and located off the plane. Five pulsars are associated with sources included in the Fermi-LAT bright γ-ray source list, but only one, PSR J1413-6205, is clearly associated with an EGRET source. PSR J1023-5746 has the smallest characteristic age (τ c = 4.6 kyr) and is the most energetic ( E-dot = 1.1x10 37 erg s -1 ) of all γ-ray pulsars discovered so far in blind searches. By analyzing >100 ks of publicly available archival Chandra X-ray data, we have identified the likely counterpart of PSR J1023-5746 as a faint, highly absorbed source, CXOU J102302.8-574606. The large X-ray absorption indicates that this could be among the most distant γ-ray pulsars detected so far. PSR J1023-5746 is positionally coincident with the TeV source HESS J1023-575, located near the young stellar cluster Westerlund 2, while PSR J1954+2836 is coincident with a 4.3σ excess reported by Milagro at a median energy of 35 TeV. PSRs J1957+5033 and J2055+25 have the largest characteristic ages (τ c ∼ 1 Myr) and are the least energetic ( E-dot ∼5x10 33 erg s -1 ) of the newly discovered pulsars. We used recent XMM observations to identify the counterpart of PSR J2055+25 as XMMU J205549.4+253959. Deep radio follow-up observations of the eight pulsars resulted in no detections of pulsations and upper limits comparable to the faintest known radio pulsars, indicating that these pulsars can be included among the growing population of radio-quiet pulsars in our Galaxy being

Pulsed Gamma Rays from the Original Millisecond and Black Widow Pulsars: A Case for Caustic Radio Emission?

Science.gov (United States)

Guillemot, L.; Johnson, T. J.; Venter, C.; Kerr, M.; Pancrazi, B.; Livingstone, M.; Janssen, G. H.; Jaroenjittichai, P.; Kramer, M.; Cognard, I.;

Diffuse γ-ray emission in the vicinity of young star cluster Westerlund 2

Science.gov (United States)

Yang, Rui-zhi; de Oña Wilhelmi, Emma; Aharonian, Felix

2018-04-01

We report the results of our analysis of the publicly available data obtained by the Large Area Telescope (LAT) on board the Fermi satellite towards the direction of the young massive star cluster Westerlund 2. We found significant extended γ-ray emission in the vicinity of Westerlund 2 with a hard power-law energy spectrum extending from 1 to 250 GeV with a photon index of 2.0 ± 0.1. We argue that amongst several alternatives, the luminous stars in Westerlund 2 are likely sites of acceleration of particles responsible for the diffuse γ-ray emission of the surrounding interstellar medium. In particular, the young star cluster Westerlund 2 can provide sufficient non-thermal energy to account for the γ-ray emission. In this scenario, since the γ-ray production region is significantly larger than the area occupied by the star cluster, we conclude that the γ-ray production is caused by hadronic interactions of accelerated protons and nuclei with the ambient gas. In that case, the total energy budget in relativistic particles is estimated of the order of 1050 erg.

OMI/Aura Surface UVB Irradiance and Erythemal Dose Daily L2 Global 0.25 deg Lat/Lon Grid V003

Data.gov (United States)

National Aeronautics and Space Administration — The Version 003 of Aura-OMI Spectral Surface UVB Irradiance and Erythemal Dose Level-2G data product (Daily level-2 data binned into global 0.25 deg Lat/Lon grids)...

Pulsed, atmospheric pressure plasma source for emission spectrometry

Science.gov (United States)

Duan, Yixiang; Jin, Zhe; Su, Yongxuan

2004-05-11

A low-power, plasma source-based, portable molecular light emission generator/detector employing an atmospheric pressure pulsed-plasma for molecular fragmentation and excitation is described. The average power required for the operation of the plasma is between 0.02 W and 5 W. The features of the optical emission spectra obtained with the pulsed plasma source are significantly different from those obtained with direct current (dc) discharge higher power; for example, strong CH emission at 431.2 nm which is only weakly observed with dc plasma sources was observed, and the intense CN emission observed at 383-388 nm using dc plasma sources was weak in most cases. Strong CN emission was only observed using the present apparatus when compounds containing nitrogen, such as aniline were employed as samples. The present apparatus detects dimethylsulfoxide at 200 ppb using helium as the plasma gas by observing the emission band of the CH radical. When coupled with a gas chromatograph for separating components present in a sample to be analyzed, the present invention provides an apparatus for detecting the arrival of a particular component in the sample at the end of the chromatographic column and the identity thereof.

The Einstein@Home Gamma-ray Pulsar Survey. II. Source Selection, Spectral Analysis, and Multiwavelength Follow-up

Science.gov (United States)

Wu, J.; Clark, C. J.; Pletsch, H. J.; Guillemot, L.; Johnson, T. J.; Torne, P.; Champion, D. J.; Deneva, J.; Ray, P. S.; Salvetti, D.; Kramer, M.; Aulbert, C.; Beer, C.; Bhattacharyya, B.; Bock, O.; Camilo, F.; Cognard, I.; Cuéllar, A.; Eggenstein, H. B.; Fehrmann, H.; Ferrara, E. C.; Kerr, M.; Machenschalk, B.; Ransom, S. M.; Sanpa-Arsa, S.; Wood, K.

2018-02-01

We report on the analysis of 13 gamma-ray pulsars discovered in the Einstein@Home blind search survey using Fermi Large Area Telescope (LAT) Pass 8 data. The 13 new gamma-ray pulsars were discovered by searching 118 unassociated LAT sources from the third LAT source catalog (3FGL), selected using the Gaussian Mixture Model machine-learning algorithm on the basis of their gamma-ray emission properties being suggestive of pulsar magnetospheric emission. The new gamma-ray pulsars have pulse profiles and spectral properties similar to those of previously detected young gamma-ray pulsars. Follow-up radio observations have revealed faint radio pulsations from two of the newly discovered pulsars and enabled us to derive upper limits on the radio emission from the others, demonstrating that they are likely radio-quiet gamma-ray pulsars. We also present results from modeling the gamma-ray pulse profiles and radio profiles, if available, using different geometric emission models of pulsars. The high discovery rate of this survey, despite the increasing difficulty of blind pulsar searches in gamma rays, suggests that new systematic surveys such as presented in this article should be continued when new LAT source catalogs become available.

TOMS/Earth Probe UV Aerosol Index Monthly L3 Global 1x1.25 deg Lat/Lon Grid V008

Data.gov (United States)

National Aeronautics and Space Administration — This data product contains TOMS/Earth Probe UV Aerosol Index Monthly L3 Global 1x1.25 deg Lat/Lon Grid Version 8 data in ASCII format. (The shortname for this...

TOMS/Nimbus-7 UV Aerosol Index Monthly L3 Global 1x1.25 deg Lat/Lon Grid V008

Data.gov (United States)

National Aeronautics and Space Administration — This data product contains TOMS/Nimbus-7 UV Aerosol Index Monthly L3 Global 1x1.25 deg Lat/Lon Grid Version 8 data in ASCII format. The Total Ozone Mapping...

TOMS/Earth Probe Total Column Ozone Daily L3 Global 1x1.25 deg Lat/Lon Grid V008

Data.gov (United States)

National Aeronautics and Space Administration — This data product contains TOMS/Earth Probe Total Column Ozone Daily L3 Global 1x1.25 deg Lat/Lon Grid Version 8 data in ASCII format. (The shortname for this...

TOMS/Nimbus-7 Total Column Ozone Monthly L3 Global 1x1.25 deg Lat/Lon Grid V008

Data.gov (United States)

National Aeronautics and Space Administration — This data product contains TOMS/Nimbus-7 Total Column Ozone Monthly L3 Global 1x1.25 deg Lat/Lon Grid Version 8 data in ASCII format. The Total Ozone Mapping...

TOMS/Nimbus-7 UV Aerosol Index Daily L3 Global 1x1.25 deg Lat/Lon Grid V008

Data.gov (United States)

National Aeronautics and Space Administration — This data product contains TOMS/Nimbus-7 UV Aerosol Index Daily L3 Global 1x1.25 deg Lat/Lon Grid Version 8 data in ASCII format. The Total Ozone Mapping...

TOMS/Nimbus-7 Total Column Ozone Daily L3 Global 1x1.25 deg Lat/Lon Grid V008

Data.gov (United States)

National Aeronautics and Space Administration — This data product contains TOMS/Nimbus-7 Total Column Ozone Daily L3 Global 1x1.25 deg Lat/Lon Grid Version 8 data in ASCII format. The Total Ozone Mapping...

DISCOVERY OF HIGH-ENERGY GAMMA-RAY EMISSION FROM THE BINARY SYSTEM PSR B1259-63/LS 2883 AROUND PERIASTRON WITH FERMI

International Nuclear Information System (INIS)

Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Bechtol, K.; Berenji, B.; Blandford, R. D.; Borgland, A. W.; Buehler, R.; Cameron, R. A.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Buson, S.; Bellazzini, R.; Bregeon, J.; Bonamente, E.; Brigida, M.; Bruel, P.; Caliandro, G. A.

2011-01-01

We report on the discovery of ≥100 MeV γ-rays from the binary system PSR B1259-63/LS 2883 using the Large Area Telescope (LAT) on board Fermi. The system comprises a radio pulsar in orbit around a Be star. We report on LAT observations from near apastron to ∼128 days after the time of periastron, t p , on 2010 December 15. No γ-ray emission was detected from this source when it was far from periastron. Faint γ-ray emission appeared as the pulsar approached periastron. At ∼t p + 30 days, the ≥100 MeV γ-ray flux increased over a period of a few days to a peak flux 20-30 times that seen during the pre-periastron period, but with a softer spectrum. For the following month, it was seen to be variable on daily timescales, but remained at ∼(1-4) x 10 -6 cm -2 s -1 before starting to fade at ∼t p + 57 days. The total γ-ray luminosity observed during this period is comparable to the spin-down power of the pulsar. Simultaneous radio and X-ray observations of the source showed no corresponding dramatic changes in radio and X-ray flux between the pre-periastron and post-periastron flares. We discuss possible explanations for the observed γ-ray-only flaring of the source.

CONTEMPORANEOUS VLBA 5 GHz OBSERVATIONS OF LARGE AREA TELESCOPE DETECTED BLAZARS

Energy Technology Data Exchange (ETDEWEB)

Linford, J. D.; Taylor, G. B. [Department of Physics and Astronomy, University of New Mexico, MSC07 4220, Albuquerque, NM 87131-0001 (United States); Romani, R. W. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Helmboldt, J. F. [Naval Research Laboratory, Code 7213, 4555 Overlook Avenue SW, Washington, DC 20375 (United States); Readhead, A. C. S.; Reeves, R.; Richards, J. L. [Astronomy Department, California Institute of Technology, Mail Code 247-17, 1200 East California Boulevard, Pasadena, CA 91125 (United States)

2012-01-10

The radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been observed contemporaneously by the Very Long Baseline Array (VLBA). In total, 232 sources were observed with the VLBA. Ninety sources that were previously observed as part of the VLBA Imaging and Polarimetry Survey (VIPS) have been included in the sample, as well as 142 sources not found in VIPS. This very large, 5 GHz flux-limited sample of active galactic nuclei (AGNs) provides insights into the mechanism that produces strong {gamma}-ray emission. In particular, we see that {gamma}-ray emission is related to strong, uniform magnetic fields in the cores of the host AGN. Included in this sample are non-blazar AGNs such as 3C84, M82, and NGC 6251. For the blazars, the total VLBA radio flux density at 5 GHz correlates strongly with {gamma}-ray flux. The LAT BL Lac objects tend to be similar to the non-LAT BL Lac objects, but the LAT flat-spectrum radio quasars (FSRQs) are significantly different from the non-LAT FSRQs. Strong core polarization is significantly more common among the LAT sources, and core fractional polarization appears to increase during LAT detection.

CONTEMPORANEOUS VLBA 5 GHz OBSERVATIONS OF LARGE AREA TELESCOPE DETECTED BLAZARS

International Nuclear Information System (INIS)

Linford, J. D.; Taylor, G. B.; Romani, R. W.; Helmboldt, J. F.; Readhead, A. C. S.; Reeves, R.; Richards, J. L.

2012-01-01

The radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been observed contemporaneously by the Very Long Baseline Array (VLBA). In total, 232 sources were observed with the VLBA. Ninety sources that were previously observed as part of the VLBA Imaging and Polarimetry Survey (VIPS) have been included in the sample, as well as 142 sources not found in VIPS. This very large, 5 GHz flux-limited sample of active galactic nuclei (AGNs) provides insights into the mechanism that produces strong γ-ray emission. In particular, we see that γ-ray emission is related to strong, uniform magnetic fields in the cores of the host AGN. Included in this sample are non-blazar AGNs such as 3C84, M82, and NGC 6251. For the blazars, the total VLBA radio flux density at 5 GHz correlates strongly with γ-ray flux. The LAT BL Lac objects tend to be similar to the non-LAT BL Lac objects, but the LAT flat-spectrum radio quasars (FSRQs) are significantly different from the non-LAT FSRQs. Strong core polarization is significantly more common among the LAT sources, and core fractional polarization appears to increase during LAT detection.

Contemporaneous VLBA 5 GHz Observations of Large Area Telescope Detected Blazars

Science.gov (United States)

Linford, J. D.; Taylor, G. B.; Romani, R. W.; Helmboldt, J. F.; Readhead, A. C. S.; Reeves, R.; Richards, J. L.

2012-01-01

The radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been observed contemporaneously by the Very Long Baseline Array (VLBA). In total, 232 sources were observed with the VLBA. Ninety sources that were previously observed as part of the VLBA Imaging and Polarimetry Survey (VIPS) have been included in the sample, as well as 142 sources not found in VIPS. This very large, 5 GHz flux-limited sample of active galactic nuclei (AGNs) provides insights into the mechanism that produces strong γ-ray emission. In particular, we see that γ-ray emission is related to strong, uniform magnetic fields in the cores of the host AGN. Included in this sample are non-blazar AGNs such as 3C84, M82, and NGC 6251. For the blazars, the total VLBA radio flux density at 5 GHz correlates strongly with γ-ray flux. The LAT BL Lac objects tend to be similar to the non-LAT BL Lac objects, but the LAT flat-spectrum radio quasars (FSRQs) are significantly different from the non-LAT FSRQs. Strong core polarization is significantly more common among the LAT sources, and core fractional polarization appears to increase during LAT detection.

Fermi LAT Pulsed Detection of PSR J0737-3039A in the Double Pulsar System

Science.gov (United States)

Guillemot, L.; Kramer, M.; Johnson, T. J.; Craig, H. A.; Romani, R. W.; Venter, C.; Harding, A. K.; Ferdman, R. D.; Stairs, I. H.; Kerr, M.

2013-01-01

We report the Fermi Large Area Telescope discovery of gamma-ray pulsations from the 22.7 ms pulsar A in the double pulsar system J0737-3039A/B. This is the first mildly recycled millisecond pulsar (MSP) detected in the GeV domain. The 2.7 s companion object PSR J0737-3039B is not detected in gamma rays. PSR J0737-3039A is a faint gamma-ray emitter, so that its spectral properties are only weakly constrained; however, its measured efficiency is typical of other MSPs. The two peaks of the gamma-ray light curve are separated by roughly half a rotation and are well offset from the radio and X-ray emission, suggesting that the GeV radiation originates in a distinct part of the magnetosphere from the other types of emission. From the modeling of the radio and the gamma-ray emission profiles and the analysis of radio polarization data, we constrain the magnetic inclination alpha and the viewing angle zeta to be close to 90 deg., which is consistent with independent studies of the radio emission from PSR J0737-3039A. A small misalignment angle between the pulsar's spin axis and the system's orbital axis is therefore favored, supporting the hypothesis that pulsar B was formed in a nearly symmetric supernova explosion as has been discussed in the literature already.

Gamma-Ray Emission of the Kes 73/1E 1841-045 Region Observed with the Fermi Large Area Telescope

Energy Technology Data Exchange (ETDEWEB)

Yeung, Paul K. H.; Kong, Albert K. H. [Institute of Astronomy and Department of Physics, National Tsing Hua University, Hsinchu, Taiwan (China); Tam, P. H. Thomas [Institute of Astronomy and Space Science, Sun Yat-Sen University, Guangzhou 510275 (China); Hui, C. Y. [Department of Astronomy and Space Science, Chungnam National University, Daejeon 305-764 (Korea, Republic of); Takata, Jumpei [School of physics, Huazhong University of Science and Technology, Wuhan 430074 (China); Cheng, K. S., E-mail: paul2012@connect.hku.hk, E-mail: akong@phys.nthu.edu.tw, E-mail: tanbxuan@mail.sysu.edu.cn [Department of Physics, University of Hong Kong, Pokfulam Road (Hong Kong)

2017-03-01

The supernova remnant (SNR) Kes 73 and/or the magnetar 1E 1841-045 at its center can deposit a large amount of energy to the surroundings and is potentially responsible for particle acceleration. Using the data taken with the Fermi Large Area Telescope (LAT), we confirmed the presence of an extended source whose centroid position is highly consistent with this magnetar/SNR pair. Its emission is intense from 100 MeV to >100 GeV. Its LAT spectrum can be decoupled into two components, which are respectively governed by two different mechanisms. According to the young age of this system, the magnetar is seemingly a necessary and sufficient source for the downward-curved spectrum below 10 GeV, as the observed <10 GeV flux is too high for the SNR to account for. On the other hand, the SNR is reasonably responsible for the hard spectrum above 10 GeV. Further studies of this region in the TeV regime is required so that we can perform physically meaningful comparisons of the >10 GeV spectrum and the TeV spectrum.

Sclérose latérale amyotrophique et traumatisme

Directory of Open Access Journals (Sweden)

M. Schachter

1959-09-01

Full Text Available À propos d'une deuxième observation personnelle de sclérose latérale amyotrophique d'origine traumatique, nous passons en revue les connaissances actuelles sur le chapitre de neuro-traumatologie. Dans l'observation présente le traumatisme cranien n'avait pas entrainé de perte de la connaissance; l'intervalle entre traumatisme et installation des premiers signes (à caractère bulbaire surtout fut de pratiquement un mois; mais on connaît des cas où cet intervalle a été de l'ordre de plusieurs années, comme dans notre première observation (15 ans. La relation entre traumatisme et maladie de Charcot est encore discutée, mais il est indubitable que ce facteur peut déclencher, à lui seul, cette maladie, sans que l'on doive faire intervenir d'autres facteurs pré-dispo-sants.

Système de prévention du risque de renversement latéral pour des véhicules évoluant en milieu naturel

OpenAIRE

Richier , M.; Lenain , R.; Thuilot , Benoît; Debain , C.

2012-01-01

International audience; Un algorithme dédié aux Véhicules Légers Tout-Terrain (VLTT) permettant l'estimation et l'anticipation du renversement est présenté dans ce papier. Il repose sur une estimation temps réel du Transfert de Charge Latéral (TCL), représentatif des instabilités dynamiques latérales. Le TCL est calculé grâce à un modèle dynamique divisé en deux projections 2D. A partir de ce modèle et d'un système de perception bas prix, un observateur est proposé. Il permet d'estimer en tem...

Optical Emissions of Sprite Streamers in Weak Electric Fields

Science.gov (United States)

Liu, N.; Pasko, V. P.

2004-12-01

Sprites commonly consist of large numbers of needle-shaped filaments of ionization [e.g., Gerken and Inan, JASTP, 65, 567, 2003] and typically initiate at altitudes 70-75 km in a form of upward and downward propagating streamers [Stanley et al., GRL, 26, 3201, 1999; Stenbaek-Nielsen et al., GRL, 27, 3829, 2000; McHarg et al., JGR, 107, 1364, 2002; Moudry et al., JASTP, 65, 509, 2003]. The strong electric fields E exceeding the conventional breakdown threshold field Ek are needed for initiation of sprite streamers from single electron avalanches and recent modeling studies indicate that streamers propagating in fields E>Ek experience strong acceleration and expansion in good agreement with the above cited observations [Liu and Pasko, JGR, 109, A04301, 2004]. The initiated streamers are capable of propagating in fields substantially lower than Ek [Allen and Ghaffar, J. Phys. D: Appl. Phys., 28, 331, 1995] and it is expected that a significant part of sprite optical output comes from regions with EEk). Additionally, the values of electric fields inside of the streamer channel are always well below Ek and since the excitation coefficients for optical emissions are very sensitive to the driving electric field magnitude most of the optical luminosity of streamers in this case arises from streamer tips, indicating that observed streamer filaments in many cases may be produced by time averaging of optical luminosity coming from localized regions around streamer tips as streamers move through an instrument's field of view. We will discuss pressure dependent differences of optical emissions at different sprite altitudes, and important similarities between observed sprite streamers and recent time resolved (van Veldhuizen et al., IEEE Trans. Plasma Sci., 30, 162, 2002; Yi and Williams, J. Phys. D. Appl. Phys., 35, 205, 2002].

Weak interactions

International Nuclear Information System (INIS)

Ogava, S.; Savada, S.; Nakagava, M.

1983-01-01

The problem of the use of weak interaction laws to study models of elementary particles is discussed. The most typical examples of weak interaction is beta-decay of nucleons and muons. Beta-interaction is presented by quark currents in the form of universal interaction of the V-A type. Universality of weak interactions is well confirmed using as examples e- and μ-channels of pion decay. Hypothesis on partial preservation of axial current is applicable to the analysis of processes with pion participation. In the framework of the model with four flavours lepton decays of hadrons are considered. Weak interaction without lepton participation are also considered. Properties of neutral currents are described briefly

Decaying dark matter in light of the PAMELA and Fermi LAT data

International Nuclear Information System (INIS)

Ibarra, Alejandro; Tran, David

2009-06-01

A series of experiments measuring high-energy cosmic rays have recently reported strong indications for the existence of an exotic source of high-energy electrons and positrons. If interpreted in terms of the decay of dark matter particles, the PAMELA measurements of the positron fraction and the Fermi LAT measurements of the total electron plus positron flux restrict the possible decaying dark matter scenarios to a few cases. Pursuing a model-independent approach, we identify some promising scenarios of dark matter decay and calculate the predictions for the diffuse extragalactic gamma-ray flux, including the contributions from inverse Compton scattering with the interstellar radiation field. (orig.)

Informação empresarial: dos sistemas transacionais à latência zero

Directory of Open Access Journals (Sweden)

Orandi Mina Falsarella

Full Text Available De cunho teórico e conceitual, o texto discorre sobre o uso das Tecnologias de Informação nas empresas em geral. Apresenta os conceitos básicos atribuídos à informação nesse ambiente e discorre sobre os diversos tipos de sistemas computadorizados de informações, disponíveis atualmente para as empresas. Discute o conceito de Latência Zero que, por meio de indicadores, contribui para o monitoramento do ambiente nas organizações, permitindo melhorar o tempo entre a ocorrência de um determinado evento e a tomada de decisão.

Weakly clopen functions

International Nuclear Information System (INIS)

Son, Mi Jung; Park, Jin Han; Lim, Ki Moon

2007-01-01

We introduce a new class of functions called weakly clopen function which includes the class of almost clopen functions due to Ekici [Ekici E. Generalization of perfectly continuous, regular set-connected and clopen functions. Acta Math Hungar 2005;107:193-206] and is included in the class of weakly continuous functions due to Levine [Levine N. A decomposition of continuity in topological spaces. Am Math Mon 1961;68:44-6]. Some characterizations and several properties concerning weakly clopenness are obtained. Furthermore, relationships among weak clopenness, almost clopenness, clopenness and weak continuity are investigated

Decoupling economic growth from CO2 emissions: A decomposition analysis of China's household energy consumption

Directory of Open Access Journals (Sweden)

Xiao-Wei Ma

2016-09-01

Full Text Available This paper analyzes Chinese household CO2 emissions in 1994–2012 based on the Logarithmic Mean Divisia Index (LMDI structure decomposition model, and discusses the relationship between household CO2 emissions and economic growth based on a decoupling indicator. The results show that in 1994–2012, household CO2 emissions grew in general and displayed an accelerated growth trend during the early 21st century. Economic growth leading to an increase in energy consumption is the main driving factor of CO2 emission growth (an increase of 1.078 Gt CO2 with cumulative contribution rate of 55.92%, while the decline in energy intensity is the main cause of CO2 emission growth inhibition (0.723 Gt CO2 emission reduction with cumulative contribution rate of 38.27%. Meanwhile, household CO2 emissions are in a weak state of decoupling in general. The change in CO2 emissions caused by population and economic growth shows a weak decoupling and expansive decoupling state, respectively. The CO2 emission change caused by energy intensity is in a state of strong decoupling, and the change caused by energy consumption structure fluctuates between a weak and a strong decoupling state.

RADIO-WEAK BL LAC OBJECTS IN THE FERMI ERA

Energy Technology Data Exchange (ETDEWEB)

Massaro, F.; Marchesini, E. J. [Dipartimento di Fisica, Università degli Studi di Torino (UniTO), via Pietro Giuria 1, I-10125 Torino (Italy); D’Abrusco, R.; Smith, Howard A. [Smithsonian Astrophysical Observatory, 60 Garden Street, 02138 Cambridge, MA (United States); Masetti, N. [INAF—Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, via Gobetti 101, I-40129, Bologna (Italy); Andruchow, I. [Facultad de Ciencias Astronómicas y Geofísicas, Universidad Nacional de La Plata, Paseo del Bosque, B1900FWA, La Plata (Argentina)

2017-01-10

The existence of “radio-weak BL Lac objects” (RWBLs) has been an open question, and has remained unsolved since the discovery that quasars could be radio-quiet or radio-loud. Recently, several groups identified RWBL candidates, mostly found while searching for low-energy counterparts of the unidentified or unassociated gamma-ray sources listed in the Fermi catalogs. Confirming RWBLs is a challenging task since they could be confused with white dwarfs (WDs) or weak emission line quasars (WELQs) when there are not sufficient data to precisely draw their broadband spectral energy distribution, and their classification is mainly based on a featureless optical spectra. Motivated by the recent discovery that Fermi BL Lacs appear to have very peculiar mid-IR emission, we show that it is possible to distinguish between WDs, WELQs, and BL Lacs using the [3.4]–[4.6]–[12] μ m color–color plot built using the WISE magnitudes when the optical spectrum is available. On the basis of this analysis, we identify WISE J064459.38+603131 and WISE J141046.00+740511.2 as the first two genuine RWBLs, both potentially associated with Fermi sources. Finally, to strengthen our identification of these objects as true RWBLs, we present multifrequency observations for these two candidates to show that their spectral behavior is indeed consistent with that of the BL Lac population.

RADIO-WEAK BL LAC OBJECTS IN THE FERMI ERA

International Nuclear Information System (INIS)

Massaro, F.; Marchesini, E. J.; D’Abrusco, R.; Smith, Howard A.; Masetti, N.; Andruchow, I.

2017-01-01

The existence of “radio-weak BL Lac objects” (RWBLs) has been an open question, and has remained unsolved since the discovery that quasars could be radio-quiet or radio-loud. Recently, several groups identified RWBL candidates, mostly found while searching for low-energy counterparts of the unidentified or unassociated gamma-ray sources listed in the Fermi catalogs. Confirming RWBLs is a challenging task since they could be confused with white dwarfs (WDs) or weak emission line quasars (WELQs) when there are not sufficient data to precisely draw their broadband spectral energy distribution, and their classification is mainly based on a featureless optical spectra. Motivated by the recent discovery that Fermi BL Lacs appear to have very peculiar mid-IR emission, we show that it is possible to distinguish between WDs, WELQs, and BL Lacs using the [3.4]–[4.6]–[12] μ m color–color plot built using the WISE magnitudes when the optical spectrum is available. On the basis of this analysis, we identify WISE J064459.38+603131 and WISE J141046.00+740511.2 as the first two genuine RWBLs, both potentially associated with Fermi sources. Finally, to strengthen our identification of these objects as true RWBLs, we present multifrequency observations for these two candidates to show that their spectral behavior is indeed consistent with that of the BL Lac population.

Weak value controversy

Science.gov (United States)

Vaidman, L.

2017-10-01

Recent controversy regarding the meaning and usefulness of weak values is reviewed. It is argued that in spite of recent statistical arguments by Ferrie and Combes, experiments with anomalous weak values provide useful amplification techniques for precision measurements of small effects in many realistic situations. The statistical nature of weak values is questioned. Although measuring weak values requires an ensemble, it is argued that the weak value, similarly to an eigenvalue, is a property of a single pre- and post-selected quantum system. This article is part of the themed issue `Second quantum revolution: foundational questions'.

O plantão noturno em anestesia reduz a latência ao sono

OpenAIRE

Mathias, Lígia Andrade da Silva Telles; Coelho, Christina Morotomi Funatsu; Vilela, Elizabeth Pricoli; Vieira, Joaquim Edson; Pagnocca, Marcelo Lacava

2004-01-01

JUSTIFICATIVA E OBJETIVOS: Os médicos em geral, os anestesiologistas em particular, têm jornadas de trabalho prolongadas. Os residentes de Anestesiologia podem apresentar fadiga e estresse significativos. O objetivo deste trabalho foi verificar, em residentes de primeiro e segundo anos a latência do sono em períodos após plantão. MÉTODO: Foram avaliados 11 residentes em situações distintas: às 7 horas da manhã, após noite de sono normal (> 7h), sem plantão nos 3 dias anteriores (M1); às 7 hor...

Evaluation of the Monotonic Lagrangian Grid and Lat-Long Grid for Air Traffic Management

Science.gov (United States)

Kaplan, Carolyn; Dahm, Johann; Oran, Elaine; Alexandrov, Natalia; Boris, Jay

2011-01-01

The Air Traffic Monotonic Lagrangian Grid (ATMLG) is used to simulate a 24 hour period of air traffic flow in the National Airspace System (NAS). During this time period, there are 41,594 flights over the United States, and the flight plan information (departure and arrival airports and times, and waypoints along the way) are obtained from an Federal Aviation Administration (FAA) Enhanced Traffic Management System (ETMS) dataset. Two simulation procedures are tested and compared: one based on the Monotonic Lagrangian Grid (MLG), and the other based on the stationary Latitude-Longitude (Lat- Long) grid. Simulating one full day of air traffic over the United States required the following amounts of CPU time on a single processor of an SGI Altix: 88 s for the MLG method, and 163 s for the Lat-Long grid method. We present a discussion of the amount of CPU time required for each of the simulation processes (updating aircraft trajectories, sorting, conflict detection and resolution, etc.), and show that the main advantage of the MLG method is that it is a general sorting algorithm that can sort on multiple properties. We discuss how many MLG neighbors must be considered in the separation assurance procedure in order to ensure a five-mile separation buffer between aircraft, and we investigate the effect of removing waypoints from aircraft trajectories. When aircraft choose their own trajectory, there are more flights with shorter duration times and fewer CD&R maneuvers, resulting in significant fuel savings.

Greenhouse gas emissions, energy consumption and economic growth: A panel cointegration analysis from Canadian industrial sector perspective

International Nuclear Information System (INIS)

Hamit-Haggar, Mahamat

2012-01-01

This paper investigates the long-run and the causal relationship between greenhouse gas emissions, energy consumption and economic growth for Canadian industrial sectors over the period 1990–2007. The empirical findings suggest that in the long-run equilibrium, energy consumption has a positive and statistically significant impact on greenhouse gas emissions whereas a non-linear relationship is found between greenhouse gas emissions and economic growth, consistent with the environmental Kuznets curve. The short-run dynamics conveys that there is a unidirectional Granger causality running from energy consumption to greenhouse gas emissions; from economic growth to greenhouse gas emissions and a weak unidirectional causality running from greenhouse gas emissions to energy consumption; from economic growth to energy consumption. In the long-run however, there seems to be a weak one way causality flowing from energy consumption and economic growth to greenhouse gas emissions. - Highlights: ► A long-run and a causal relationship between greenhouse gas emissions, energy consumption and economic growth is investigated. ► Energy consumption has a positive impact on greenhouse gas emissions in the long run. ► Unidirectional causality runs from energy consumption and economic growth to greenhouse gas emissions. ► A weak unidirectional causality runs from greenhouse gas emissions and economic growth to energy consumption.

Weak Acid Ionization Constants and the Determination of Weak Acid-Weak Base Reaction Equilibrium Constants in the General Chemistry Laboratory

Science.gov (United States)

Nyasulu, Frazier; McMills, Lauren; Barlag, Rebecca

2013-01-01

A laboratory to determine the equilibrium constants of weak acid negative weak base reactions is described. The equilibrium constants of component reactions when multiplied together equal the numerical value of the equilibrium constant of the summative reaction. The component reactions are weak acid ionization reactions, weak base hydrolysis…

FERMI LAT PULSED DETECTION OF PSR J0737-3039A IN THE DOUBLE PULSAR SYSTEM

Energy Technology Data Exchange (ETDEWEB)

Guillemot, L.; Kramer, M. [Max-Planck-Institut fuer Radioastronomie, Auf dem Huegel 69, D-53121 Bonn (Germany); Johnson, T. J. [National Research Council Research Associate, National Academy of Sciences, Washington, DC 20001 (United States); Craig, H. A.; Romani, R. W.; Kerr, M. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Venter, C. [Centre for Space Research, North-West University, Potchefstroom Campus, Private Bag X6001, 2520 Potchefstroom (South Africa); Harding, A. K. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Ferdman, R. D. [Jodrell Bank Centre for Astrophysics, School of Physics and Astronomy, The University of Manchester, M13 9PL (United Kingdom); Stairs, I. H., E-mail: guillemo@mpifr-bonn.mpg.de [Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z1 (Canada)

2013-05-10

We report the Fermi Large Area Telescope discovery of {gamma}-ray pulsations from the 22.7 ms pulsar A in the double pulsar system J0737-3039A/B. This is the first mildly recycled millisecond pulsar (MSP) detected in the GeV domain. The 2.7 s companion object PSR J0737-3039B is not detected in {gamma} rays. PSR J0737-3039A is a faint {gamma}-ray emitter, so that its spectral properties are only weakly constrained; however, its measured efficiency is typical of other MSPs. The two peaks of the {gamma}-ray light curve are separated by roughly half a rotation and are well offset from the radio and X-ray emission, suggesting that the GeV radiation originates in a distinct part of the magnetosphere from the other types of emission. From the modeling of the radio and the {gamma}-ray emission profiles and the analysis of radio polarization data, we constrain the magnetic inclination {alpha} and the viewing angle {zeta} to be close to 90 Degree-Sign , which is consistent with independent studies of the radio emission from PSR J0737-3039A. A small misalignment angle between the pulsar's spin axis and the system's orbital axis is therefore favored, supporting the hypothesis that pulsar B was formed in a nearly symmetric supernova explosion as has been discussed in the literature already.

Italian Physical Society Galactic diffuse neutrino component in the astrophysical excess measured by the IceCube experiment

CERN Document Server

Grasso, D; Marinelli, A; Taoso, M; Urbano, A

2017-01-01

The Galaxy is a guaranteed source of neutrinos produced by the interaction of cosmic rays (CRs) with the interstellar gas. According to conventional CR propagation models, however, this emission may be too weak to be detected even by km3-scale neutrino telescopes. This expectation has to be revisited in the light of recent Fermi LAT findings showing that the CR spectrum in the inner Galactic plane is significantly harder than that inferred from local CR measurements. Here we discuss some relevant predictions of a phenomenological model —based on a spatially-dependent CR diffusion —which was recently developed to reproduce that large-scale trend. In particular, we show how that model correctly predicts the TeV γ-ray diffuse emission measured by Milagro and H.E.S.S. in the inner Galaxy. We will then compute the corresponding neutrino emission, compare it with ANTARES and IceCube results and discuss the perspectives of KM3NeT.

The radio and optical counterpart of the new Fermi LAT flaring source J0109+6134

Science.gov (United States)

Paredes, J. M.; Martí, J.; Peracaula, M.

2010-02-01

Following the recent ATELs #2414, #2416 and #2420 concerning the Fermi-LAT, AGILE and Swift/XRT consistent detections of the new gamma-ray flaring source J0109+6134, we wish to remind that the proposed radio counterpart (VCS2 J0109+6133/GT 0106+613) was extensively observed nearly two decades ago by different authors in the context of the GT catalogue of Galactic Plane radio sources (Taylor and Gregory 1983, AJ, 88, 1784; Gregory and Taylor 1986, AJ 92, 371).

The Problem of Weak Governments and Weak Societies in Eastern Europe

Directory of Open Access Journals (Sweden)

Marko Grdešić

2008-01-01

Full Text Available This paper argues that, for Eastern Europe, the simultaneous presence of weak governments and weak societies is a crucial obstacle which must be faced by analysts and reformers. The understanding of other normatively significant processes will be deficient without a consciousness-raising deliberation on this problem and its implications. This paper seeks to articulate the “relational” approach to state and society. In addition, the paper lays out a typology of possible patterns of relationship between state and society, dependent on whether the state is weak or strong and whether society is weak or strong. Comparative data are presented in order to provide an empirical support for the theses. Finally, the paper outlines two reform approaches which could enable breaking the vicious circle emerging in the context of weak governments and weak societies.

FERMI LARGE AREA TELESCOPE OBSERVATIONS OF GAMMA-RAY PULSARS PSR J1057-5226, J1709-4429, AND J1952+3252

International Nuclear Information System (INIS)

Abdo, A. A.; Ajello, M.; Bechtol, K.; Berenji, B.; Borgland, A. W.; Bouvier, A.; Buehler, R.; Antolini, E.; Bonamente, E.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Brez, A.; Ballet, J.; Barbiellini, G.; Baring, M. G.; Bastieri, D.; Brigida, M.; Bruel, P.; Burnett, T. H.

2010-01-01

The Fermi Large Area Telescope (LAT) data have confirmed the pulsed emission from all six high-confidence gamma-ray pulsars previously known from the EGRET observations. We report results obtained from the analysis of 13 months of LAT data for three of these pulsars (PSR J1057-5226, PSR J1709-4429, and PSR J1952+3252) each of which had some unique feature among the EGRET pulsars. The excellent sensitivity of LAT allows more detailed analysis of the evolution of the pulse profile with energy and also of the variation of the spectral shape with phase. We measure the cutoff energy of the pulsed emission from these pulsars for the first time and provide a more complete picture of the emission mechanism. The results confirm some, but not all, of the features seen in the EGRET data.

A search for neutrino emission from the Fermi bubbles with the ANTARES telescope

Energy Technology Data Exchange (ETDEWEB)

Adrian-Martinez, S.; Ardid, M.; Larosa, G.; Martinez-Mora, J.A. [Universitat Politecnica de Valencia, Institut d' Investigacio per a la Gestio Integrada de les Zones Costaneres (IGIC), Gandia (Spain); Albert, A.; Drouhin, D.; Racca, C. [GRPHE, Institut Universitaire de Technologie de Colmar, 34 rue du Grillenbreit, BP 50568, Colmar (France); Al Samarai, I.; Aubert, J.J.; Bertin, V.; Brunner, J.; Busto, J.; Carr, J.; Charif, Z.; Core, L.; Costantini, H.; Coyle, P.; Curtil, C.; Dornic, D.; Ernenwein, J.P.; Escoffier, S.; Lambard, E.; Riviere, C.; Vallee, C.; Vecchi, M.; Yatkin, K. [CPPM, Aix-Marseille Universite, CNRS/IN2P3, Marseille (France); Andre, M. [Technical University of Catalonia, Laboratory of Applied Bioacoustics, Vilanova i la Geltru, Barcelona (Spain); Anton, G.; Classen, F.; Eberl, T.; Enzenhoefer, A.; Fehn, K.; Folger, F.; Fritsch, U.; Geisselsoeder, S.; Geyer, K.; Gleixner, A.; Graf, K.; Herold, B.; Hoessl, J.; James, C.W.; Kalekin, O.; Kappes, A.; Katz, U.; Lahmann, R.; Neff, M.; Richter, R.; Roensch, K.; Schmid, J.; Schnabel, J.; Seitz, T.; Shanidze, R.; Sieger, C.; Spies, A.; Wagner, S. [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen Centre for Astroparticle Physics, Erlangen (Germany); Anvar, S.; Louis, F.; Schuessler, F.; Stolarczyk, T.; Vallage, B.; Vernin, P. [Institut de recherche sur les lois fondamentales de l' Univers, Service d' Electronique des Detecteurs et d' Informatique, CEA Saclay, Direction des Sciences de la Matiere, Gif-sur-Yvette Cedex (France); Astraatmadja, T.; Bogazzi, C.; Heijboer, A.J.; Jong, M. de; Michael, T.; Palioselitis, D.; Schulte, S.; Steijger, J.J.M.; Visser, E. [Nikhef, Science Park, Amsterdam (Netherlands); Baret, B.; Bouhou, B.; Creusot, A.; Galata, S.; Kouchner, A.; Elewyck, V. van [APC, Universite Paris Diderot, CNRS/IN2P3, CEA/IRFU, Observatoire de Paris, Sorbonne Paris Cite, Paris (France); Barrios-Marti, J.; Bigongiari, C.; Bouwhuis, M.C.; Emanuele, U.; Gomez-Gonzalez, J.P.; Hernandez-Rey, J.J.; Lambard, G.; Mangano, S.; Sanchez-Losa, A.; Yepes, H.; Zornoza, J.D.; Zuniga, J. [Universitat de Valencia, IFIC, Instituto de Fisica Corpuscular, Edificios Investigacion de Paterna, CSIC, Valencia (Spain); Basa, S.; Marcelin, M.; Nezri, E. [Pole de l' Etoile Site de Chateau-Gombert, LAM, Laboratoire d' Astrophysique de Marseille, Marseille Cedex 13 (France); Biagi, S.; Fusco, L.A.; Giacomelli, G.; Margiotta, A.; Spurio, M. [INFN, Sezione di Bologna, Bologna (Italy); Dipartimento di Fisica dell' Universita, Bologna (Italy); Capone, A.; De Bonis, G.; Fermani, P.; Perrina, C.; Simeone, F. [INFN, Sezione di Roma, Rome (Italy); Dipartimento di Fisica dell' Universita La Sapienza, Rome (Italy); Caramete, L.; Pavalas, G.E.; Popa, V. [Institute for Space Sciences, Bucharest, Magurele (Romania); Carloganu, C.; Dumas, A.; Gay, P.; Guillard, G. [Clermont Universite, Universite Blaise Pascal, CNRS/IN2P3, Laboratoire de Physique Corpusculaire, BP 10448, Clermont-Ferrand (France); Cecchini, S.; Chiarusi, T. [INFN, Sezione di Bologna, Bologna (Italy); Charvis, P.; Deschamps, A.; Hello, Y. [Geoazur, Universite Nice Sophia-Antipolis, CNRS/INSU, IRD, Observatoire de la Cote d' Azur, Sophia Antipolis (France); Circella, M. [INFN, Sezione di Bari, Bari (Italy); Coniglione, R.; Lattuada, D.; Riccobene, G.; Sapienza, P.; Trovato, A. [INFN, Laboratori Nazionali del Sud (LNS), Catania (Italy); Dekeyser, I.; Lefevre, D.; Martini, S.; Robert, A.; Tamburini, C. [Mediterranean Institute of Oceanography (MIO), Aix-Marseille University, Marseille Cedex 9 (France); Universit du Sud Toulon-Var, CNRS-INSU/IRD UM 110, La Garde Cedex (France); Donzaud, C. [APC, Universite Paris Diderot, CNRS/IN2P3, CEA/IRFU, Observatoire de Paris, Sorbonne Paris Cite, Paris (France); Universite Paris-Sud, Orsay Cedex (France); Dorosti, Q.; Loehner, H. [University of Groningen, Kernfysisch Versneller Instituut (KVI), Groningen (Netherlands); Flaminio, V. [INFN, Sezione di Pisa, Pisa (Italy); Dipartimento di Fisica dell' Universita, Pisa (Italy); Giordano, V. [INFN, Sezione di Catania, Catania (Italy); Haren, H. van [Royal Netherlands Institute for Sea Research (NIOZ), ' t Horntje (Texel) (Netherlands); Hugon, C.; Sanguineti, M. [INFN, Sezione di Genova, Genoa (Italy); Kadler, M. [Universitaet Wuerzburg, Institut fuer Theoretische Physik und Astrophysik, Wuerzburg (Germany); Kooijman, P. [Nikhef, Science Park, Amsterdam (Netherlands); Universiteit Utrecht, Faculteit Betawetenschappen, Utrecht (Netherlands); Universiteit van Amsterdam, Instituut voor Hoge-Energie Fysica, Amsterdam (Netherlands); Kreykenbohm, I.; Mueller, C.; Wilms, J. [Universitaet Erlangen-Nuernberg, Dr. Remeis-Sternwarte and ECAP, Bamberg (Germany); Kulikovskiy, V. [INFN, Sezione di Genova, Genoa (Italy); Moscow State University, Skobeltsyn Institute of Nuclear Physics, Moscow (Russian Federation); Leonora, E.; Lo Presti, D. [INFN, Sezione di Catania, Catania (Italy); Dipartimento di Fisica ed Astronomia dell' Universita, Catania (Italy); Loucatos, S. [Institut de recherche sur les lois fondamentales de l' Univers, Service d' Electronique des Detecteurs et d' Informatique, CEA Saclay, Direction des Sciences de la Matiere, Gif-sur-Yvette Cedex (France); APC, Universite Paris Diderot, CNRS/IN2P3, CEA/IRFU, Observatoire de Paris, Sorbonne Paris Cite, Paris (France); Montaruli, T. [Mediterranean Institute of Oceanography (MIO), Aix-Marseille University, Marseille Cedex 9 (France); Universite de Geneve, Departement de Physique Nucleaire et Corpusculaire, Geneva (Switzerland); Morganti, M. [INFN, Sezione di Pisa, Pisa (Italy); Pradier, T. [Universite de Strasbourg et CNRS/IN2P3, IPHC-Institut Pluridisciplinaire Hubert Curien, 23 rue du Loess, BP 28, Strasbourg Cedex 2 (France); Rostovtsev, A. [ITEP, Institute for Theoretical and Experimental Physics, Moscow (Russian Federation); Samtleben, D.F.E. [Nikhef, Science Park, Amsterdam (Netherlands); Universiteit Leiden, Leids Instituut voor Onderzoek in Natuurkunde, Leiden (Netherlands); Taiuti, M. [Technical University of Catalonia, Laboratory of Applied Bioacoustics, Vilanova i la Geltru, Barcelona (Spain); Dipartimento di Fisica dell' Universita, Genoa (IT); Tayalati, Y. [University Mohammed I, Laboratory of Physics of Matter and Radiations, B.P.717, Oujda (MA); Wolf, E. de [Nikhef, Science Park, Amsterdam (NL); Universiteit van Amsterdam, Instituut voor Hoge-Energie Fysica, Amsterdam (NL); Collaboration: The ANTARES Collaboration

2014-02-15

Analysis of the Fermi-LAT data has revealed two extended structures above and below the Galactic Centre emitting gamma rays with a hard spectrum, the so-called Fermi bubbles. Hadronic models attempting to explain the origin of the Fermi bubbles predict the emission of high-energy neutrinos and gamma rays with similar fluxes. The ANTARES detector, a neutrino telescope located in the Mediterranean Sea, has a good visibility to the Fermi bubble regions. Using data collected from 2008 to 2011 no statistically significant excess of events is observed and therefore upper limits on the neutrino flux in TeV range from the Fermi bubbles are derived for various assumed energy cutoffs of the source. (orig.)

A search for neutrino emission from the Fermi bubbles with the ANTARES telescope

International Nuclear Information System (INIS)

Adrian-Martinez, S.; Ardid, M.; Larosa, G.; Martinez-Mora, J.A.; Albert, A.; Drouhin, D.; Racca, C.; Al Samarai, I.; Aubert, J.J.; Bertin, V.; Brunner, J.; Busto, J.; Carr, J.; Charif, Z.; Core, L.; Costantini, H.; Coyle, P.; Curtil, C.; Dornic, D.; Ernenwein, J.P.; Escoffier, S.; Lambard, E.; Riviere, C.; Vallee, C.; Vecchi, M.; Yatkin, K.; Andre, M.; Anton, G.; Classen, F.; Eberl, T.; Enzenhoefer, A.; Fehn, K.; Folger, F.; Fritsch, U.; Geisselsoeder, S.; Geyer, K.; Gleixner, A.; Graf, K.; Herold, B.; Hoessl, J.; James, C.W.; Kalekin, O.; Kappes, A.; Katz, U.; Lahmann, R.; Neff, M.; Richter, R.; Roensch, K.; Schmid, J.; Schnabel, J.; Seitz, T.; Shanidze, R.; Sieger, C.; Spies, A.; Wagner, S.; Anvar, S.; Louis, F.; Schuessler, F.; Stolarczyk, T.; Vallage, B.; Vernin, P.; Astraatmadja, T.; Bogazzi, C.; Heijboer, A.J.; Jong, M. de; Michael, T.; Palioselitis, D.; Schulte, S.; Steijger, J.J.M.; Visser, E.; Baret, B.; Bouhou, B.; Creusot, A.; Galata, S.; Kouchner, A.; Elewyck, V. van; Barrios-Marti, J.; Bigongiari, C.; Bouwhuis, M.C.; Emanuele, U.; Gomez-Gonzalez, J.P.; Hernandez-Rey, J.J.; Lambard, G.; Mangano, S.; Sanchez-Losa, A.; Yepes, H.; Zornoza, J.D.; Zuniga, J.; Basa, S.; Marcelin, M.; Nezri, E.; Biagi, S.; Fusco, L.A.; Giacomelli, G.; Margiotta, A.; Spurio, M.; Capone, A.; De Bonis, G.; Fermani, P.; Perrina, C.; Simeone, F.; Caramete, L.; Pavalas, G.E.; Popa, V.; Carloganu, C.; Dumas, A.; Gay, P.; Guillard, G.; Cecchini, S.; Chiarusi, T.; Charvis, P.; Deschamps, A.; Hello, Y.; Circella, M.; Coniglione, R.; Lattuada, D.; Riccobene, G.; Sapienza, P.; Trovato, A.; Dekeyser, I.; Lefevre, D.; Martini, S.; Robert, A.; Tamburini, C.; Donzaud, C.; Dorosti, Q.; Loehner, H.; Flaminio, V.; Giordano, V.; Haren, H. van; Hugon, C.; Sanguineti, M.; Kadler, M.; Kooijman, P.; Kreykenbohm, I.; Mueller, C.; Wilms, J.; Kulikovskiy, V.; Leonora, E.; Lo Presti, D.; Loucatos, S.; Montaruli, T.; Morganti, M.; Pradier, T.; Rostovtsev, A.; Samtleben, D.F.E.; Taiuti, M.; Tayalati, Y.; Wolf, E. de

2014-01-01

Analysis of the Fermi-LAT data has revealed two extended structures above and below the Galactic Centre emitting gamma rays with a hard spectrum, the so-called Fermi bubbles. Hadronic models attempting to explain the origin of the Fermi bubbles predict the emission of high-energy neutrinos and gamma rays with similar fluxes. The ANTARES detector, a neutrino telescope located in the Mediterranean Sea, has a good visibility to the Fermi bubble regions. Using data collected from 2008 to 2011 no statistically significant excess of events is observed and therefore upper limits on the neutrino flux in TeV range from the Fermi bubbles are derived for various assumed energy cutoffs of the source. (orig.)

Electro-weak theory

International Nuclear Information System (INIS)

Deshpande, N.G.

1980-01-01

By electro-weak theory is meant the unified field theory that describes both weak and electro-magnetic interactions. The development of a unified electro-weak theory is certainly the most dramatic achievement in theoretical physics to occur in the second half of this century. It puts weak interactions on the same sound theoretical footing as quantum elecrodynamics. Many theorists have contributed to this development, which culminated in the works of Glashow, Weinberg and Salam, who were jointly awarded the 1979 Nobel Prize in physics. Some of the important ideas that contributed to this development are the theory of beta decay formulated by Fermi, Parity violation suggested by Lee and Yang, and incorporated into immensely successful V-A theory of weak interactions by Sudarshan and Marshak. At the same time ideas of gauge invariance were applied to weak interaction by Schwinger, Bludman and Glashow. Weinberg and Salam then went one step further and wrote a theory that is renormalizable, i.e., all higher order corrections are finite, no mean feat for a quantum field theory. The theory had to await the development of the quark model of hadrons for its completion. A description of the electro-weak theory is given

Weak decays

International Nuclear Information System (INIS)

Wojcicki, S.

1978-11-01

Lectures are given on weak decays from a phenomenological point of view, emphasizing new results and ideas and the relation of recent results to the new standard theoretical model. The general framework within which the weak decay is viewed and relevant fundamental questions, weak decays of noncharmed hadrons, decays of muons and the tau, and the decays of charmed particles are covered. Limitation is made to the discussion of those topics that either have received recent experimental attention or are relevant to the new physics. (JFP) 178 references

PSR J2030+364I: Radio Discovery and Gamma-ray Study of a Middle-aged Pulsar in the Now Identified Fermi-LAT Source 1FGL J2030.0+3641

Science.gov (United States)

Camilo, F.; Kerr, M.; Ray, P. S.; Ransom, S. M.; Johnston, S.; Romani, R. W.; Parent, D.; Decesar, M. E.; Harding, A. K.; Donato, D.;

Weak currents

International Nuclear Information System (INIS)

Leite Lopes, J.

1976-01-01

A survey of the fundamental ideas on weak currents such as CVC and PCAC and a presentation of the Cabibbo current and the neutral weak currents according to the Salam-Weinberg model and the Glashow-Iliopoulos-Miami model are given [fr

Discovery of Pulsed Gamma Rays from the Young Radio Pulsar PSR J1028-5819 with the Fermi Large Area Telescope

Energy Technology Data Exchange (ETDEWEB)

Abdo, Aous A.; /Naval Research Lab, Wash., D.C.; Ackermann, M.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Atwood, W.B.; /UC, Santa Cruz; Baldini, L.; /INFN, Pisa; Ballet, J.; /DAPNIA, Saclay; Barbiellini, Guido; /INFN, Trieste /Trieste U.; Baring, Matthew G.; /Rice U.; Bastieri, Denis; /INFN, Padua /Padua U.; Baughman, B.M.; /Ohio State U.; Bechtol, K.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bellazzini, R.; /INFN, Pisa; Berenji, B.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bloom, Elliott D.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bonamente, E.; /INFN, Perugia /Perugia U.; Borgland, A.W.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bregeon, J.; /INFN, Pisa; Brez, A.; /INFN, Pisa; Brigida, M.; /Bari U. /INFN, Bari; Bruel, P.; /Ecole Polytechnique; Burnett, Thompson H.; /Washington U., Seattle; Caliandro, G.A.; /Bari U. /INFN, Bari /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /IASF, Milan /IASF, Milan /DAPNIA, Saclay /INFN, Perugia /Perugia U. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /George Mason U. /Naval Research Lab, Wash., D.C. /NASA, Goddard /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /INFN, Perugia /Perugia U. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Montpellier U. /Sonoma State U. /Stockholm U., OKC /Royal Inst. Tech., Stockholm /Stockholm U. /Naval Research Lab, Wash., D.C. /INFN, Trieste /Bari U. /INFN, Bari /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /NASA, Goddard /UC, Santa Cruz /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /CENBG, Gradignan /CENBG, Gradignan /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Montpellier U. /Bari U. /INFN, Bari /Ecole Polytechnique /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /INFN, Trieste /Hiroshima U. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; /more authors..

2009-05-15

Radio pulsar PSR J1028-5819 was recently discovered in a high-frequency search (at 3.1 GHz) in the error circle of the Energetic Gamma-Ray Experiment Telescope (EGRET) source 3EG J1027-5817. The spin-down power of this young pulsar is great enough to make it very likely the counterpart for the EGRET source. We report here the discovery of {gamma}-ray pulsations from PSR J1028-5819 in early observations by the Large Area Telescope (LAT) on the Fermi Gamma-Ray Space Telescope. The {gamma}-ray light curve shows two sharp peaks having phase separation of 0.460 {+-} 0.004, trailing the very narrow radio pulse by 0.200 {+-} 0.003 in phase, very similar to that of other known {gamma}-ray pulsars. The measured {gamma}-ray flux gives an efficiency for the pulsar of {approx}10-20% (for outer magnetosphere beam models). No evidence of a surrounding pulsar wind nebula is seen in the current Fermi data but limits on associated emission are weak because the source lies in a crowded region with high background emission. However, the improved angular resolution afforded by the LAT enables the disentanglement of the previous COS-B and EGRET source detections into at least two distinct sources, one of which is now identified as PSR J1028-5819.

Relação entre potenciais evocados auditivos de média latência e distúrbio de processamento auditivo: estudo de casos

Directory of Open Access Journals (Sweden)

Ana Carla Leite Romero

2013-04-01

Full Text Available O Potencial Evocado Auditivo de Média Latência é um teste objetivo promissor na audiologia na pesquisa neuro-diagnóstica das disfunções do sistema auditivo. Tem como vantagens a precisão e objetividade na avaliação e por isso é útil em crianças. O presente estudo teve como objetivo analisar os potenciais evocados auditivos de média latência em dois pacientes com distúrbio de processamento auditivo e relacionar as medidas objetivas e comportamentais. Para tanto foi realizado estudo de caso de dois pacientes (P1= feminino, 12 anos; P2= masculino, 17 anos, ambos com ausência de alterações sensoriais, distúrbios neurológicos, neuropsiquiátricos. Ambos foram submetidos à anamnese, inspeção do meato acústico externo, avaliação audiológica e avaliação do exame de potencial evocado auditivo de média latência. Houve associação significante entre os resultados dos exames comportamentais e objetivos. Na anamnese, houve queixas referentes à dificuldade de escuta em ambiente ruidoso, localização sonora, desatenção, além de trocas fonológicas na escrita e na fala. Foram observadas alterações no processo de decodificação auditiva à direita em ambos os casos na avaliação comportamental do processamento auditivo e no exame de potencial evocado auditivo de média latência a resposta da via contralateral direita foi deficitária, confirmando as dificuldades dos pacientes estudados na atribuição de significado às informações acústicas em condição de competição sonora à direita nos dois casos. Para os casos estudados comprovou-se à associação entre os resultados, porém há necessidade de novos estudos com maior amostra para confirmação dos dados.

Homological properties of modules with finite weak injective and weak flat dimensions

OpenAIRE

Zhao, Tiwei

2017-01-01

In this paper, we define a class of relative derived functors in terms of left or right weak flat resolutions to compute the weak flat dimension of modules. Moreover, we investigate two classes of modules larger than that of weak injective and weak flat modules, study the existence of covers and preenvelopes, and give some applications.

Fermi LAT detection of renewed strong GeV activity from the FSRQ 3C 279

Science.gov (United States)

Ojha, Roopesh; van Zyl, Pfesesani; Fermi Large Area Telescope Collaboration

2018-04-01

The Large Area Telescope (LAT), one of two instruments on the Fermi Gamma-ray Space Telescope, has observed an intense and hard gamma-ray flare from a source positionally consistent with the flat spectrum radio quasar 3C 279, also known as 3FGL J1256.1-0547 (Acero et al. 2015, ApJS, 218, 23), with radio coordinates R.A.: 12h56m11.1665s, Dec: -05d47m21.523s (J2000.0; Johnston et al. 1995, AJ, 110, 880).

Influence of Herpes Simplex Virus Latency-Associated Transcript (LAT) on the Distribution of Latently Infected Neurons

Science.gov (United States)

2007-03-20

the Qiagen AllPrep DNA/RNA Minikit ( Valencia , CA) after homogenization with an Omni rotor-stator homogenizer with disposable tips (Omni...VP19, VP23, and VP26. VP5 makes pentons ( orange ) and hexons (red), connected by triplexes of VP19 and VP23 (green). Hexons are decorated at the...A. Mallakin, D. C. Bloom , and J. M. Hill. 2003. Overlapping subdeletions within a 348-bp in the 5’ exon of the LAT region that facilitates

A multi-frequency analysis of possible dark matter contributions to M31 gamma-ray emissions

Energy Technology Data Exchange (ETDEWEB)

Beck, G.; Colafrancesco, S., E-mail: geoffrey.beck@wits.ac.za, E-mail: sergio.colafrancesco@wits.ac.za [School of Physics, University of the Witwatersrand, Private Bag 3, WITS-2050, Johannesburg (South Africa)

2017-10-01

We examine the possibility of a dark matter (DM) contribution to the recently observed gamma-ray spectrum seen in the M31 galaxy. In particular, we apply limits on Weakly Interacting Massive Particle DM annihilation cross-sections derived from the Coma galaxy cluster and the Reticulum II dwarf galaxy to determine the maximal flux contribution by DM annihilation to both the M31 gamma-ray spectrum and that of the Milky-Way Galactic Centre. We limit the energy range between 1 and 12 GeV in M31 and Galactic Centre spectra due to the limited range of former's data, as well as to encompass the high-energy gamma-ray excess observed in the latter target. In so doing, we will make use of Fermi-LAT data for all mentioned targets, as well as diffuse radio data for the Coma cluster. The multi-target strategy using both Coma and Reticulum II to derive cross-section limits, as well as multi-frequency data, ensures that our results are robust against the various uncertainties inherent in modelling of indirect DM emissions. Our results indicate that, when a Navarro-Frenk-White (or shallower) radial density profile is assumed, severe constraints can be imposed upon the fraction of the M31 and Galactic Centre spectra that can be accounted for by DM, with the best limits arising from cross-section constraints from Coma radio data and Reticulum II gamma-ray limits. These particular limits force all the studied annihilation channels to contribute 1% or less to the total integrated gamma-ray flux within both M31 and Galactic Centre targets. In contrast, considerably more, 10−100%, of the flux can be attributed to DM when a contracted Navarro-Frenk-White profile is assumed. This demonstrates how sensitive DM contributions to gamma-ray emissions are to the possibility of cored profiles in galaxies. The only channel consistently excluded for all targets and profiles (except for ∼ 10 GeV WIMPs) is the direct annihilation into photons. Finally, we discuss the ramifications of

MINUTE-TIMESCALE >100 MeV γ -RAY VARIABILITY DURING THE GIANT OUTBURST OF QUASAR 3C 279 OBSERVED BY FERMI -LAT IN 2015 JUNE

Energy Technology Data Exchange (ETDEWEB)

Ackermann, M.; Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Anantua, R.; Baldini, L.; Blandford, R. D.; Bloom, E. D.; Bottacini, E.; Caliandro, G. A.; Cameron, R. A. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Asano, K. [Institute for Cosmic-Ray Research, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8582 (Japan); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Gonzalez, J. Becerra [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bissaldi, E.; Caragiulo, M. [Istituto Nazionale di Fisica Nucleare, Sezione di Bari, I-70126 Bari (Italy); Bonino, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, I-10125 Torino (Italy); Bruel, P. [Laboratoire Leprince-Ringuet, École polytechnique, CNRS/IN2P3, F-91128 Palaiseau (France); Caraveo, P. A. [INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica, I-20133 Milano (Italy); Cavazzuti, E. [Agenzia Spaziale Italiana (ASI) Science Data Center, I-00133 Roma (Italy); and others

2016-06-20

On 2015 June 16, Fermi -LAT observed a giant outburst from the flat spectrum radio quasar 3C 279 with a peak >100 MeV flux of ∼3.6 × 10{sup −5} photons cm{sup −2} s{sup −1}, averaged over orbital period intervals. It is historically the highest γ -ray flux observed from the source, including past EGRET observations, with the γ -ray isotropic luminosity reaching ∼10{sup 49} erg s{sup −1}. During the outburst, the Fermi spacecraft, which has an orbital period of 95.4 minutes, was operated in a special pointing mode to optimize the exposure for 3C 279. For the first time, significant flux variability at sub-orbital timescales was found in blazar observations by Fermi -LAT. The source flux variability was resolved down to 2-minute binned timescales, with flux doubling times of less than 5 minutes. The observed minute-scale variability suggests a very compact emission region at hundreds of Schwarzschild radii from the central engine in conical jet models. A minimum bulk jet Lorentz factor (Γ) of 35 is necessary to avoid both internal γ -ray absorption and super-Eddington jet power. In the standard external radiation Comptonization scenario, Γ should be at least 50 to avoid overproducing the synchrotron self-Compton component. However, this predicts extremely low magnetization (∼5 × 10{sup −4}). Equipartition requires Γ as high as 120, unless the emitting region is a small fraction of the dissipation region. Alternatively, we consider γ rays originating as synchrotron radiation of γ {sub e} ∼ 1.6 × 10{sup 6} electrons, in a magnetic field B ∼ 1.3 kG, accelerated by strong electric fields E ∼ B in the process of magnetoluminescence. At such short distance scales, one cannot immediately exclude the production of γ -rays in hadronic processes.

A large sample of Kohonen-selected SDSS quasars with weak emission lines: selection effects and statistical properties

Science.gov (United States)

Meusinger, H.; Balafkan, N.

2014-08-01

Aims: A tiny fraction of the quasar population shows remarkably weak emission lines. Several hypotheses have been developed, but the weak line quasar (WLQ) phenomenon still remains puzzling. The aim of this study was to create a sizeable sample of WLQs and WLQ-like objects and to evaluate various properties of this sample. Methods: We performed a search for WLQs in the spectroscopic data from the Sloan Digital Sky Survey Data Release 7 based on Kohonen self-organising maps for nearly 105 quasar spectra. The final sample consists of 365 quasars in the redshift range z = 0.6 - 4.2 (z¯ = 1.50 ± 0.45) and includes in particular a subsample of 46 WLQs with equivalent widths WMg iiattention was paid to selection effects. Results: The WLQs have, on average, significantly higher luminosities, Eddington ratios, and accretion rates. About half of the excess comes from a selection bias, but an intrinsic excess remains probably caused primarily by higher accretion rates. The spectral energy distribution shows a bluer continuum at rest-frame wavelengths ≳1500 Å. The variability in the optical and UV is relatively low, even taking the variability-luminosity anti-correlation into account. The percentage of radio detected quasars and of core-dominant radio sources is significantly higher than for the control sample, whereas the mean radio-loudness is lower. Conclusions: The properties of our WLQ sample can be consistently understood assuming that it consists of a mix of quasars at the beginning of a stage of increased accretion activity and of beamed radio-quiet quasars. The higher luminosities and Eddington ratios in combination with a bluer spectral energy distribution can be explained by hotter continua, i.e. higher accretion rates. If quasar activity consists of subphases with different accretion rates, a change towards a higher rate is probably accompanied by an only slow development of the broad line region. The composite WLQ spectrum can be reasonably matched by the

New ALMA and Fermi /LAT Observations of the Large-scale Jet of PKS 0637−752 Strengthen the Case Against the IC/CMB Model

Energy Technology Data Exchange (ETDEWEB)

Meyer, Eileen T.; Breiding, Peter; Georganopoulos, Markos [University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250 (United States); Oteo, Iván; Ivison, R. J. [Institute for Astronomy, University of Edinburgh, Royal Observatory, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom); Zwaan, Martin A.; Laing, Robert [European Southern Observatory, Karl-Schwarzschild-Str. 2, D-85748 Garching-bei-München (Germany); Godfrey, Leith, E-mail: meyer@umbc.edu [ASTRON, the Netherlands Institute for Radio Astronomy, Postbus 2, 7990 AA Dwingeloo (Netherlands)

2017-02-01

The Chandra X-ray observatory has discovered several dozen anomalously X-ray-bright jets associated with powerful quasars. A popular explanation for the X-ray flux from the knots in these jets is that relativistic synchrotron-emitting electrons inverse-Compton scatter cosmic microwave background (CMB) photons to X-ray energies (the IC/CMB model). This model predicts a high gamma-ray flux that should be detectable by the Fermi /Large Area Telescope (LAT) for many sources. GeV-band upper limits from Fermi /LAT for the well-known anomalous X-ray jet in PKS 0637−752 were previously shown in Meyer et al. to violate the predictions of the IC/CMB model. Previously, measurements of the jet synchrotron spectrum, important for accurately predicting the gamma-ray flux level, were lacking between radio and infrared wavelengths. Here, we present new Atacama Large Millimeter/submillimeter Array (ALMA) observations of the large-scale jet at 100, 233, and 319 GHz, which further constrain the synchrotron spectrum, supporting the previously published empirical model. We also present updated limits from the Fermi /LAT using the new “Pass 8” calibration and approximately 30% more time on source. With these deeper limits, we rule out the IC/CMB model at the 8.7 σ level. Finally, we demonstrate that complete knowledge of the synchrotron SED is critical in evaluating the IC/CMB model.

A STATISTICAL APPROACH TO RECOGNIZING SOURCE CLASSES FOR UNASSOCIATED SOURCES IN THE FIRST FERMI-LAT CATALOG

Energy Technology Data Exchange (ETDEWEB)

Ackermann, M. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Ajello, M.; Allafort, A.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Buehler, R. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Antolini, E.; Bonamente, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Perugia, I-06123 Perugia (Italy); Baldini, L.; Bellazzini, R.; Bregeon, J. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Universite Paris Diderot, Service d' Astrophysique, CEA Saclay, 91191 Gif sur Yvette (France); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bouvier, A. [Santa Cruz Institute for Particle Physics, Department of Physics and Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Brandt, T. J. [CNRS, IRAP, F-31028 Toulouse Cedex 4 (France); Brigida, M. [Dipartimento di Fisica ' M. Merlin' dell' Universita e del Politecnico di Bari, I-70126 Bari (Italy); Bruel, P., E-mail: monzani@slac.stanford.edu, E-mail: vilchez@cesr.fr, E-mail: salvetti@lambrate.inaf.it, E-mail: elizabeth.c.ferrara@nasa.gov [Laboratoire Leprince-Ringuet, Ecole polytechnique, CNRS/IN2P3, Palaiseau (France); and others

2012-07-01

The Fermi Large Area Telescope (LAT) First Source Catalog (1FGL) provided spatial, spectral, and temporal properties for a large number of {gamma}-ray sources using a uniform analysis method. After correlating with the most-complete catalogs of source types known to emit {gamma} rays, 630 of these sources are 'unassociated' (i.e., have no obvious counterparts at other wavelengths). Here, we employ two statistical analyses of the primary {gamma}-ray characteristics for these unassociated sources in an effort to correlate their {gamma}-ray properties with the active galactic nucleus (AGN) and pulsar populations in 1FGL. Based on the correlation results, we classify 221 AGN-like and 134 pulsar-like sources in the 1FGL unassociated sources. The results of these source 'classifications' appear to match the expected source distributions, especially at high Galactic latitudes. While useful for planning future multiwavelength follow-up observations, these analyses use limited inputs, and their predictions should not be considered equivalent to 'probable source classes' for these sources. We discuss multiwavelength results and catalog cross-correlations to date, and provide new source associations for 229 Fermi-LAT sources that had no association listed in the 1FGL catalog. By validating the source classifications against these new associations, we find that the new association matches the predicted source class in {approx}80% of the sources.

A STATISTICAL APPROACH TO RECOGNIZING SOURCE CLASSES FOR UNASSOCIATED SOURCES IN THE FIRST FERMI-LAT CATALOG

International Nuclear Information System (INIS)

Ackermann, M.; Ajello, M.; Allafort, A.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Buehler, R.; Antolini, E.; Bonamente, E.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bouvier, A.; Brandt, T. J.; Brigida, M.; Bruel, P.

2012-01-01

The Fermi Large Area Telescope (LAT) First Source Catalog (1FGL) provided spatial, spectral, and temporal properties for a large number of γ-ray sources using a uniform analysis method. After correlating with the most-complete catalogs of source types known to emit γ rays, 630 of these sources are 'unassociated' (i.e., have no obvious counterparts at other wavelengths). Here, we employ two statistical analyses of the primary γ-ray characteristics for these unassociated sources in an effort to correlate their γ-ray properties with the active galactic nucleus (AGN) and pulsar populations in 1FGL. Based on the correlation results, we classify 221 AGN-like and 134 pulsar-like sources in the 1FGL unassociated sources. The results of these source 'classifications' appear to match the expected source distributions, especially at high Galactic latitudes. While useful for planning future multiwavelength follow-up observations, these analyses use limited inputs, and their predictions should not be considered equivalent to 'probable source classes' for these sources. We discuss multiwavelength results and catalog cross-correlations to date, and provide new source associations for 229 Fermi-LAT sources that had no association listed in the 1FGL catalog. By validating the source classifications against these new associations, we find that the new association matches the predicted source class in ∼80% of the sources.

Extending the Fermi-LAT data processing pipeline to the grid

Energy Technology Data Exchange (ETDEWEB)

Zimmer, S. [Stockholm Univ., Stockholm (Sweden); The Oskar Klein Centre for Cosmoparticle Physics, Stockholm (Sweden); Arrabito, L. [Univ. Montpellier 2, Montpellier (France); Glanzman, T. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Johnson, T. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Lavalley, C. [Univ. Montpellier 2, Montpellier (France); Tsaregorodtsev, A. [Centre de Physique des Particules de Marseille, Marseille (France)

2015-05-12

The Data Handling Pipeline ("Pipeline") has been developed for the Fermi Gamma-Ray Space Telescope (Fermi) Large Area Telescope (LAT) which launched in June 2008. Since then it has been in use to completely automate the production of data quality monitoring quantities, reconstruction and routine analysis of all data received from the satellite and to deliver science products to the collaboration and the Fermi Science Support Center. Aside from the reconstruction of raw data from the satellite (Level 1), data reprocessing and various event-level analyses are also reasonably heavy loads on the pipeline and computing resources. These other loads, unlike Level 1, can run continuously for weeks or months at a time. Additionally, it receives heavy use in performing production Monte Carlo tasks.

GAMMA-RAY EMISSION FROM TWO BLAZARS BEHIND THE GALACTIC PLANE: B2013+370 AND B2023+336

International Nuclear Information System (INIS)

Kara, E.; Errando, M.; Aliu, E.; Mukherjee, R.; Max-Moerbeck, W.; Readhead, A. C. S.; Richards, J. L.; Böttcher, M.; Fortin, P.; Halpern, J. P.

2012-01-01

B2013+370 and B2023+336 are two blazars at low-galactic latitude that were previously proposed to be the counterparts for the EGRET unidentified sources 3EG J2016+3657 and 3EG J2027+3429. Gamma-ray emission associated with the EGRET sources has been detected by the Fermi Gamma-ray Space Telescope, and the two sources, 1FGL J2015.7+3708 and 1FGL J2027.6+3335, have been classified as unidentified in the 1 year catalog. This analysis of the Fermi Large Area Telescope (LAT) data collected during 31 months reveals that the 1FGL sources are spatially compatible with the blazars and are significantly variable, supporting the hypothesis of extragalactic origin for the gamma-ray emission. The gamma-ray light curves are compared with 15 GHz radio light curves from the 40 m telescope at the Owens Valley Radio Observatory. Simultaneous variability is seen in both bands for the two blazar candidates. The study is completed with the X-ray analysis of 1FGL J2015.7+3708 using Swift observations that were triggered in 2010 August by a Fermi-detected flare. The resulting spectral energy distribution shows a two-component structure typical of blazars. We also identify a second source in the field of view of 1FGL J2027.6+3335 with similar characteristics to the known LAT pulsars. This study gives solid evidence favoring blazar counterparts for these two unidentified EGRET and Fermi sources, supporting the hypothesis that a number of unidentified gamma-ray sources at low-galactic latitudes are indeed of extragalactic origin.

TOMS/Earth Probe UV-B Erythemal Local Noon Irradiance Monthly L3 Global 1x1.25 deg Lat/Lon Grid V008

Data.gov (United States)

National Aeronautics and Space Administration — This data product contains TOMS/Earth Probe UV-B Erythemal Local Noon Irradiance Monthly L3 Global 1x1.25 deg Lat/Lon Grid Version 8 data in ASCII format. (The...

Rocket-borne EUV-visible emission measurements

International Nuclear Information System (INIS)

Schmidtke, G.; Baker, K.D.; Stasek, G.

1982-01-01

Two rocket-borne experiments for measuring EUV atmospheric emissions have been conducted. The first measured emissions at 391.4 nm and 557.7 nm, and the second measured emissions in the range from 50 to 650 nm. Height profiles of selected auroral emissions from atomic oxygen at 130.4 nm (exhibiting resonant radiation diffusion) and from atomic oxygen at 557.7 nm, and from neutral and ionized molecular nitrogen are shown. Some details of the recorded spectra are given. In the shorter wavelength regions, emissions from atomic oxygen and nitrogen dominate. Over 140 nm, Lyman-Birge-Hopfield bands, second positive bands and Vegard-Kaplan bands of molecular nitrogen contribute most strongly except for some atomic lines. The Lyman-Birge-Hopfield bands of molecular nitrogen are relatively weak during the auroral arc as compared to the diffuse aurora

THE SECOND FERMI LARGE AREA TELESCOPE CATALOG OF GAMMA-RAY PULSARS

Energy Technology Data Exchange (ETDEWEB)

Abdo, A. A. [Center for Earth Observing and Space Research, College of Science, George Mason University, Fairfax, VA 22030 (United States); Ajello, M. [Space Sciences Laboratory, 7 Gauss Way, University of California, Berkeley, CA 94720-7450 (United States); Allafort, A.; Bloom, E. D.; Bottacini, E. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Baldini, L. [Università di Pisa and Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d' Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Baring, M. G. [Rice University, Department of Physics and Astronomy, MS-108, P.O. Box 1892, Houston, TX 77251 (United States); Bastieri, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Belfiore, A. [Santa Cruz Institute for Particle Physics, Department of Physics and Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Bellazzini, R.; Bregeon, J. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bhattacharyya, B. [National Centre for Radio Astrophysics, Tata Institute of Fundamental Research, Pune 411 007 (India); Bissaldi, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, and Università di Trieste, I-34127 Trieste (Italy); Bonamente, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Perugia, I-06123 Perugia (Italy); Brandt, T. J. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Brigida, M., E-mail: hartog@stanford.edu [Dipartimento di Fisica ' ' M. Merlin' ' dell' Università e del Politecnico di Bari, I-70126 Bari (Italy); and others

2013-10-01

This catalog summarizes 117 high-confidence ≥0.1 GeV gamma-ray pulsar detections using three years of data acquired by the Large Area Telescope (LAT) on the Fermi satellite. Half are neutron stars discovered using LAT data through periodicity searches in gamma-ray and radio data around LAT unassociated source positions. The 117 pulsars are evenly divided into three groups: millisecond pulsars, young radio-loud pulsars, and young radio-quiet pulsars. We characterize the pulse profiles and energy spectra and derive luminosities when distance information exists. Spectral analysis of the off-peak phase intervals indicates probable pulsar wind nebula emission for four pulsars, and off-peak magnetospheric emission for several young and millisecond pulsars. We compare the gamma-ray properties with those in the radio, optical, and X-ray bands. We provide flux limits for pulsars with no observed gamma-ray emission, highlighting a small number of gamma-faint, radio-loud pulsars. The large, varied gamma-ray pulsar sample constrains emission models. Fermi's selection biases complement those of radio surveys, enhancing comparisons with predicted population distributions.

The second FERMI large area telescope catalog of gamma-ray pulsars

Energy Technology Data Exchange (ETDEWEB)

Abdo, A. A.; Ajello, M.; Allafort, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Baring, M. G.; Bastieri, D.; Belfiore, A.; Bellazzini, R.; Bhattacharyya, B.; Bissaldi, E.; Bloom, E. D.; Bonamente, E.; Bottacini, E.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Burgay, M.; Burnett, T. H.; Busetto, G.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Camilo, F.; Caraveo, P. A.; Casandjian, J. M.; Cecchi, C.; Çelik, Ö.; Charles, E.; Chaty, S.; Chaves, R. C. G.; Chekhtman, A.; Chen, A. W.; Chiang, J.; Chiaro, G.; Ciprini, S.; Claus, R.; Cognard, I.; Cohen-Tanugi, J.; Cominsky, L. R.; Conrad, J.; Cutini, S.; D' Ammando, F.; de Angelis, A.; DeCesar, M. E.; De Luca, A.; den Hartog, P. R.; de Palma, F.; Dermer, C. D.; Desvignes, G.; Digel, S. W.; Di Venere, L.; Drell, P. S.; Drlica-Wagner, A.; Dubois, R.; Dumora, D.; Espinoza, C. M.; Falletti, L.; Favuzzi, C.; Ferrara, E. C.; Focke, W. B.; Franckowiak, A.; Freire, P. C. C.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Germani, S.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Gotthelf, E. V.; Grenier, I. A.; Grondin, M. -H.; Grove, J. E.; Guillemot, L.; Guiriec, S.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Hessels, J.; Hewitt, J.; Hill, A. B.; Horan, D.; Hou, X.; Hughes, R. E.; Jackson, M. S.; Janssen, G. H.; Jogler, T.; Jóhannesson, G.; Johnson, R. P.; Johnson, A. S.; Johnson, T. J.; Johnson, W. N.; Johnston, S.; Kamae, T.; Kataoka, J.; Keith, M.; Kerr, M.; Knödlseder, J.; Kramer, M.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Lemoine-Goumard, M.; Longo, F.; Loparco, F.; Lovellette, M. N.; Lubrano, P.; Lyne, A. G.; Manchester, R. N.; Marelli, M.; Massaro, F.; Mayer, M.; Mazziotta, M. N.; McEnery, J. E.; McLaughlin, M. A.; Mehault, J.; Michelson, P. F.; Mignani, R. P.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nakamori, T.; Nemmen, R.; Nuss, E.; Ohno, M.; Ohsugi, T.; Orienti, M.; Orlando, E.; Ormes, J. F.; Paneque, D.; Panetta, J. H.; Parent, D.; Perkins, J. S.; Pesce-Rollins, M.; Pierbattista, M.; Piron, F.; Pivato, G.; Pletsch, H. J.; Porter, T. A.; Possenti, A.; Rainò, S.; Rando, R.; Ransom, S. M.; Ray, P. S.; Razzano, M.; Rea, N.; Reimer, A.; Reimer, O.; Renault, N.; Reposeur, T.; Ritz, S.; Romani, R. W.; Roth, M.; Rousseau, R.; Roy, J.; Ruan, J.; Sartori, A.; Saz Parkinson, P. M.; Scargle, J. D.; Schulz, A.; Sgrò, C.; Shannon, R.; Siskind, E. J.; Smith, D. A.; Spandre, G.; Spinelli, P.; Stappers, B. W.; Strong, A. W.; Suson, D. J.; Takahashi, H.; Thayer, J. G.; Thayer, J. B.; Theureau, G.; Thompson, D. J.; Thorsett, S. E.; Tibaldo, L.; Tibolla, O.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Uchiyama, Y.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Venter, C.; Vianello, G.; Vitale, V.; Wang, N.; Weltevrede, P.; Winer, B. L.; Wolff, M. T.; Wood, D. L.; Wood, K. S.; Wood, M.; Yang, Z.

2013-09-19

This catalog summarizes 117 high-confidence ≥0.1 GeV gamma-ray pulsar detections using three years of data acquired by the Large Area Telescope (LAT) on the Fermi satellite. Half are neutron stars discovered using LAT data through periodicity searches in gamma-ray and radio data around LAT unassociated source positions. The 117 pulsars are evenly divided into three groups: millisecond pulsars, young radio-loud pulsars, and young radio-quiet pulsars. We characterize the pulse profiles and energy spectra and derive luminosities when distance information exists. Spectral analysis of the off-peak phase intervals indicates probable pulsar wind nebula emission for four pulsars, and off-peak magnetospheric emission for several young and millisecond pulsars. We compare the gamma-ray properties with those in the radio, optical, and X-ray bands. We provide flux limits for pulsars with no observed gamma-ray emission, highlighting a small number of gamma-faint, radio-loud pulsars. The large, varied gamma-ray pulsar sample constrains emission models. Fermi's selection biases complement those of radio surveys, enhancing comparisons with predicted population distributions.

The second fermi large area telescope catalog of gamma-ray pulsars

Energy Technology Data Exchange (ETDEWEB)

Abdo, A. A.; Ajello, M.; Allafort, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Baring, M. G.; Bastieri, D.; Belfiore, A.; Bellazzini, R.; Bhattacharyya, B.; Bissaldi, E.; Bloom, E. D.; Bonamente, E.; Bottacini, E.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Burgay, M.; Burnett, T. H.; Busetto, G.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Camilo, F.; Caraveo, P. A.; Casandjian, J. M.; Cecchi, C.; Çelik, Ö.; Charles, E.; Chaty, S.; Chaves, R. C. G.; Chekhtman, A.; Chen, A. W.; Chiang, J.; Chiaro, G.; Ciprini, S.; Claus, R.; Cognard, I.; Cohen-Tanugi, J.; Cominsky, L. R.; Conrad, J.; Cutini, S.; D' Ammando, F.; de Angelis, A.; DeCesar, M. E.; De Luca, A.; den Hartog, P. R.; de Palma, F.; Dermer, C. D.; Desvignes, G.; Digel, S. W.; Di Venere, L.; Drell, P. S.; Drlica-Wagner, A.; Dubois, R.; Dumora, D.; Espinoza, C. M.; Falletti, L.; Favuzzi, C.; Ferrara, E. C.; Focke, W. B.; Franckowiak, A.; Freire, P. C. C.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Germani, S.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Gotthelf, E. V.; Grenier, I. A.; Grondin, M. -H.; Grove, J. E.; Guillemot, L.; Guiriec, S.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Hessels, J.; Hewitt, J.; Hill, A. B.; Horan, D.; Hou, X.; Hughes, R. E.; Jackson, M. S.; Janssen, G. H.; Jogler, T.; Jóhannesson, G.; Johnson, R. P.; Johnson, A. S.; Johnson, T. J.; Johnson, W. N.; Johnston, S.; Kamae, T.; Kataoka, J.; Keith, M.; Kerr, M.; Knödlseder, J.; Kramer, M.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Lemoine-Goumard, M.; Longo, F.; Loparco, F.; Lovellette, M. N.; Lubrano, P.; Lyne, A. G.; Manchester, R. N.; Marelli, M.; Massaro, F.; Mayer, M.; Mazziotta, M. N.; McEnery, J. E.; McLaughlin, M. A.; Mehault, J.; Michelson, P. F.; Mignani, R. P.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nakamori, T.; Nemmen, R.; Nuss, E.; Ohno, M.; Ohsugi, T.; Orienti, M.; Orlando, E.; Ormes, J. F.; Paneque, D.; Panetta, J. H.; Parent, D.; Perkins, J. S.; Pesce-Rollins, M.; Pierbattista, M.; Piron, F.; Pivato, G.; Pletsch, H. J.; Porter, T. A.; Possenti, A.; Rainò, S.; Rando, R.; Ransom, S. M.; Ray, P. S.; Razzano, M.; Rea, N.; Reimer, A.; Reimer, O.; Renault, N.; Reposeur, T.; Ritz, S.; Romani, R. W.; Roth, M.; Rousseau, R.; Roy, J.; Ruan, J.; Sartori, A.; Saz Parkinson, P. M.; Scargle, J. D.; Schulz, A.; Sgrò, C.; Shannon, R.; Siskind, E. J.; Smith, D. A.; Spandre, G.; Spinelli, P.; Stappers, B. W.; Strong, A. W.; Suson, D. J.; Takahashi, H.; Thayer, J. G.; Thayer, J. B.; Theureau, G.; Thompson, D. J.; Thorsett, S. E.; Tibaldo, L.; Tibolla, O.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Uchiyama, Y.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Venter, C.; Vianello, G.; Vitale, V.; Wang, N.; Weltevrede, P.; Winer, B. L.; Wolff, M. T.; Wood, D. L.; Wood, K. S.; Wood, M.; Yang, Z.

2013-09-19

This catalog summarizes 117 high-confidence ≥0.1 GeV gamma-ray pulsar detections using three years of data acquired by the Large Area Telescope (LAT) on the Fermi satellite. Half are neutron stars discovered using LAT data through periodicity searches in gamma-ray and radio data around LAT unassociated source positions. The 117 pulsars are evenly divided into three groups: millisecond pulsars, young radio-loud pulsars, and young radio-quiet pulsars. We characterize the pulse profiles and energy spectra and derive luminosities when distance information exists. Spectral analysis of the off-peak phase intervals indicates probable pulsar wind nebula emission for four pulsars, and off-peak magnetospheric emission for several young and millisecond pulsars. We compare the gamma-ray properties with those in the radio, optical, and X-ray bands. We provide flux limits for pulsars with no observed gamma-ray emission, highlighting a small number of gamma-faint, radio-loud pulsars. The large, varied gamma-ray pulsar sample constrains emission models. Fermi's selection biases complement those of radio surveys, enhancing comparisons with predicted population distributions.

TOMS/Nimbus-7 UV-B Erythemal Local Noon Irradiance Daily L3 Global 1x1.25 deg Lat/Lon Grid V008

Data.gov (United States)

National Aeronautics and Space Administration — This data product contains TOMS/Nimbus-7 UV-B Erythemal Local Noon Irradiance Daily L3 Global 1x1.25 deg Lat/Lon Grid Version 8 data in ASCII format. The Total Ozone...

Hartman effect and weak measurements that are not really weak

International Nuclear Information System (INIS)

Sokolovski, D.; Akhmatskaya, E.

2011-01-01

We show that in wave packet tunneling, localization of the transmitted particle amounts to a quantum measurement of the delay it experiences in the barrier. With no external degree of freedom involved, the envelope of the wave packet plays the role of the initial pointer state. Under tunneling conditions such ''self-measurement'' is necessarily weak, and the Hartman effect just reflects the general tendency of weak values to diverge, as postselection in the final state becomes improbable. We also demonstrate that it is a good precision, or a 'not really weak' quantum measurement: no matter how wide the barrier d, it is possible to transmit a wave packet with a width σ small compared to the observed advancement. As is the case with all weak measurements, the probability of transmission rapidly decreases with the ratio σ/d.

Implication of the detection of very hard spectra from the TeV blazar Mrk 501

Energy Technology Data Exchange (ETDEWEB)

Shukla, Amit; Hughes, Gareth; Biland, Adrian [ETH Zurich, Institute for Particle Physics (Switzerland); Mannheim, Karl; Dorner, Daniela [Institute for Theoretical Physics and Astrophysics, Universitaet Wuerzburg (Germany); Chitnis, Varsha R. [Department of High Energy Physics, Tata Institute of Fundamental Research, Mumbai (India); Roy, Jayashree; Acharya, Bannanje Sripathi [Center for Excellence in Basic Sciences, UM-DAE Mumbai (India)

2016-07-01

The emission from active galactic nuclei ranges from radio to TeV energies and shows high variability. The origin of the high energy emission is highly debated. The observed emission could be due to a complex superposition of emission from multiple zones. New evidence of the detection of very hard intrinsic gamma-ray spectra obtained from Fermi-LAT observations have challenged the theories about origin of VHE gamma-rays. We have used the 7 years of Fermi-LAT data to search for time intervals with unusually hard spectra from the nearby TeV blazar Mrk 501. In the presentation, we discuss a few possible explanations for the origin of these hard spectra within a leptonic scenario.

Seborrheic Keratoses as the First Sign of Bladder Carcinoma: Case Report of Leser-Trélat Sign in a Rare Association with Urinary Tract Cancer

Directory of Open Access Journals (Sweden)

Aline Stollmeier

2016-01-01

Full Text Available Introduction. Skin disorders can be the first manifestation of occult diseases. The recognition of typical paraneoplastic dermatoses may anticipate the cancer diagnosis and improve its prognosis. Although rarely observed, the sudden appearance and/or rapid increase in number and size of seborrheic keratoses can be associated with malignant neoplasms, known as the sign of Leser-Trélat. The aim of this report is to unveil a case of a patient whose recently erupted seborrheic keratoses led to investigation and consequent diagnosis of bladder cancer. Case Presentation. A 67-year-old man was admitted to the intensive care unit due to an exacerbation of chronic obstructive pulmonary disease (COPD. On physical examination, multiple seborrheic keratoses on the back of the hands, elbows, and trunk were observed; the patient had a 4-month history of these lesions yet was asymptomatic. The possibility of Leser-Trélat syndrome justified the investigation for neoplasia, and a bladder carcinoma was detected by CT-scan. The patient denied previous hematuria or any other related symptoms. Many of the lesions regressed during oncologic treatment. Conclusion. Despite the critics on the validity of the sign of Leser-Trélat, our patient fulfills the description of the disease, though urinary malignancy is a rare association. That corroborates the need of further investigation when there is a possibility of paraneoplastic manifestation.

Neutron star formation and the weak interaction

International Nuclear Information System (INIS)

Burrows, A.

1986-01-01

The only known direct diagnostic of the central event is its neutrino emission. The imprint of the entire internal evolution is stamped on the spectrum, mix of flavors, luminosities, and features of the accompanying neutrino burst. Detection and scrutiny of this neutrino signal will test theories concerning stellar collapse, type II supernovae, and the formation of neutron stars in ways impossible by other means. Despite the fact that an incredible 3x10 53 ergs may be emitted in neutrinos after the initiation of collapse, the very weakness of the neutrino/matter interaction that allows them to penetrate the stellar envelope and escape makes their detection at the Earth very difficult. Though neutrino astronomy is not yet a mature discipline, the physical theories of collapse have progressed to a sufficient degree that specific and detailed predictions can be made about the neutrino emissions that with future detector technology might be tested. The time seems propitious to summarize and review what is known and suspected about the neutrino signature of collapse, the potential for its detection, and how it can be used to test our ideas about the death of massive stars and the birth of neutrino stars. (orig./BBOE)

AN HISTORICAL OVERVIEW OF THE IMPORTANCE OF THE WEAK DECAY OF HYPERNUCLEI

International Nuclear Information System (INIS)

GIBSON, B.F.

2001-01-01

Weak decay of hypernuclei, first cousin to the β-decay of conventional, nonstrange nuclei, was initially observed in the 1950s. Pionic decay rates have proven a challenge--to reconcile nuclear decay rates with that of free λ decay. Pauli blocking of the decay nucleon plays an important role. Nonmesonic decay provides our only practical means of exploring the four-fermion, strangeness-changing NΛ → NN weak interaction. The NΛρ vertex can be investigated in no other way. The large momentum transfer in the nonmesonic decay process suggests a means to probe short distance aspects of the interaction, possibly revealing baryon substructure effects. Whether the ΔI = 1/2 rule, which governs free Λ decay, also applies to the nonmesonic decay process remains an open question. The free Λ does not decay by emission of a π + ; the π + decay of 4 He is a puzzle. Finally, the weak decay of strangeness -2 hypernuclei is an important topic, because the pionic decay process is central to current efforts to seek and identify ΛΛ hypernuclei

Weak KAM theory for a weakly coupled system of Hamilton–Jacobi equations

KAUST Repository

Figalli, Alessio; Gomes, Diogo A.; Marcon, Diego

2016-01-01

Here, we extend the weak KAM and Aubry–Mather theories to optimal switching problems. We consider three issues: the analysis of the calculus of variations problem, the study of a generalized weak KAM theorem for solutions of weakly coupled systems of Hamilton–Jacobi equations, and the long-time behavior of time-dependent systems. We prove the existence and regularity of action minimizers, obtain necessary conditions for minimality, extend Fathi’s weak KAM theorem, and describe the asymptotic limit of the generalized Lax–Oleinik semigroup. © 2016, Springer-Verlag Berlin Heidelberg.

Weak KAM theory for a weakly coupled system of Hamilton–Jacobi equations

KAUST Repository

Figalli, Alessio

2016-06-23

Here, we extend the weak KAM and Aubry–Mather theories to optimal switching problems. We consider three issues: the analysis of the calculus of variations problem, the study of a generalized weak KAM theorem for solutions of weakly coupled systems of Hamilton–Jacobi equations, and the long-time behavior of time-dependent systems. We prove the existence and regularity of action minimizers, obtain necessary conditions for minimality, extend Fathi’s weak KAM theorem, and describe the asymptotic limit of the generalized Lax–Oleinik semigroup. © 2016, Springer-Verlag Berlin Heidelberg.

Organic random lasers in the weak-scattering regime

CERN Document Server

Polson, R C; 10.1103/PhysRevB.71.045205

2005-01-01

We used the ensemble-averaged power Fourier transform (PFT) of random laser emission spectra over the illuminated area to study random lasers with coherent feedback in four different disordered organic gain media in the weak scattering regime, where the light mean free path, l* is much larger than the emission wavelength. The disordered gain media include a pi -conjugated polymer film, an opal photonic crystal infiltrated with a laser dye (rhodamine 6G; R6G) having optical gain in the visible spectral range, a suspension of titania balls in R6G solution, and biological tissues such as chicken breast infiltrated with R6G. We show the existence of universality among the random resonators in each gain medium that we tested, in which at the same excitation intensity a dominant random cavity is excited in different parts of the sample. We show a second universality when scaling the average PFT of the four different media by l*; we found that the dominant cavity in each disordered gain medium scales with l *. The e...

Fermi-LAT Constraints on the Pulsar Wind Nebula Nature of HESS J1857+026

Science.gov (United States)

Rousseau, R.; Grondin, M.-H.; VanEtten, A.; Lemoine-Goumard, M.; Bogdanov, S.; Hessels, J. W. T.; Kaspi, V. M.; Arzoumanian, Z.; Camilo, F.; Casandjian, J. M.;

Effect of equatorial electrodynamics on low-latitude thermosphere as inferred from neutral optical dayglow emission observations

Science.gov (United States)

Karan, D. K.; Duggirala, P. R.

2017-12-01

The diurnal variations in daytime airglow emission intensity measurements at three wavelengths OI 777.4 nm, OI 630.0 nm, and OI 557.7 nm made from a low-latitude location, Hyderabad (Geographic 17.50 N, 78.40 E; 8.90 N Mag. Lat) in India have been investigated. The intensity patterns showed both symmetric and asymmetric behavior in their respective diurnal emission variability with respect to local noon. The asymmetric diurnal behavior is not expected considering the photochemical nature of the production mechanisms. The reason for this observed asymmetric diurnal behavior has been found to be predominantly the temporal variation in the equatorial electrodynamics. The plasma that is transported across latitudes due to the action of varying electric field strength over the magnetic equator in the daytime contributes to the asymmetric diurnal behavior in the neutral daytime airglow emissions. Independent magnetic and radio measurements support this finding. It is also noted that this asymmetric diurnal behavior in the neutral emission intensities has a solar cycle dependence with more number of days during high solar activity period showing asymmetric diurnal behavior compared to those during low-solar activity epoch. These intensity variations over long time scale demonstrate that the daytime neutral optical emissions are extremely sensitive to the changes in the eastward electric field over low- and equatorial-latitudes.

HYDROACOUSTIC OBSERVATIONS OF WEAK EARTHQUAKES IN SHALLOW WATERS OF THE SOUTHERN KURIL ISLANDS

Directory of Open Access Journals (Sweden)

Alexander S. Borisov

2012-01-01

Full Text Available Results of hydroacoustic observations of signals from weak earthquakes in natural conditions in the region of the Southern Kuril Islands are presented. Some earthquakes were registered by the the Yuzhno-Kurilsk Seismic Station, other were only recorded by hydrophone stations. The observations were specific as seismic signals were recorded in shallow waters, i.e. in high noise level conditions. Hydrophones were installed in Lake Lagunnoe (Kunashir and Khromovaya Bay (Shikotan. Our analysis of hydroacoustic records received from the hydrophone stations revealed no evident precursory response of the geological medium to weak distant events. This means that neither before the period of earthquake preparation nor during the earthquake preparation period, any geoacoustic emission was not detected. It is shown that despite the unfavourable noise level conditions, even distant weak earthquakes can be confidently registered by hydrophone stations, and pending application of proper signal processing techniques, it can be possible to determine arrival times of seismic waves and to measure parameters of seismic waves. It is also established that the frequency spectrum of acoustic signals from the weak earthquakes recordable by the hydrophone stations is continuous and of noise type in the frequency range up to 90–100 Hz. It is revealed that in some cases, weak earthquakes and microearthquakes may be forerun by low frequency signals.

Dark-Matter Particles without Weak-Scale Masses or Weak Interactions

International Nuclear Information System (INIS)

Feng, Jonathan L.; Kumar, Jason

2008-01-01

We propose that dark matter is composed of particles that naturally have the correct thermal relic density, but have neither weak-scale masses nor weak interactions. These models emerge naturally from gauge-mediated supersymmetry breaking, where they elegantly solve the dark-matter problem. The framework accommodates single or multiple component dark matter, dark-matter masses from 10 MeV to 10 TeV, and interaction strengths from gravitational to strong. These candidates enhance many direct and indirect signals relative to weakly interacting massive particles and have qualitatively new implications for dark-matter searches and cosmological implications for colliders

Weak maser emission of methyl formate toward Sagittarius B2(N) in the green bank telescope PRIMOS survey

Energy Technology Data Exchange (ETDEWEB)

Faure, A.; Wiesenfeld, L. [UJF-Grenoble 1/CNRS-INSU, Institut de Planétologie et d' Astrophysique de Grenoble (IPAG) UMR 5274, Grenoble F-38041 (France); Remijan, A. J. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Szalewicz, K. [Department of Physics and Astronomy, University of Delaware, Newark, DE 19716 (United States)

2014-03-10

A non-LTE radiative transfer treatment of cis-methyl formate (HCOOCH{sub 3}) rotational lines is presented for the first time using a set of theoretical collisional rate coefficients. These coefficients have been computed in the temperature range 5-30 K by combining coupled-channel scattering calculations with a high accuracy potential energy surface for HCOOCH{sub 3}-He. The results are compared to observations toward the Sagittarius B2(N) molecular cloud using the publicly available PRIMOS survey from the Green Bank Telescope. A total of 49 low-lying transitions of methyl formate, with upper levels below 25 K, are identified. These lines are found to probe a presumably cold (∼30 K), moderately dense (∼10{sup 4} cm{sup –3}), and extended region surrounding Sgr B2(N). The derived column density of ∼4 × 10{sup 14} cm{sup –2} is only a factor of ∼10 larger than the column density of the trans conformer in the same source. Provided that the two conformers have the same spatial distribution, this result suggests that strongly non-equilibrium processes must be involved in their synthesis. Finally, our calculations show that all detected emission lines with a frequency below 30 GHz are (collisionally pumped) weak masers amplifying the continuum of Sgr B2(N). This result demonstrates the importance and generality of non-LTE effects in the rotational spectra of complex organic molecules at centimeter wavelengths.

Stochastic Evolution Equations Driven by Fractional Noises

Science.gov (United States)

2016-11-28

paper is to establish the weak convergence, in the topology of the Skorohod space, of the ν-symmetric Riemann sums for functionals of the fractional...stochastic heat equation with fractional-colored noise: existence of the solution. ALEA Lat. Am. J. Probab. Math . Stat. 4 (2008), 57–87. [8] P. Carmona, Y...Hu: Strong disorder implies strong localization for directed polymers in a random environment. ALEA Lat. Am. J. Probab. Math . Stat. 2 (2006), 217

The program of reclaim negotiable emission licensing: situation and lessons

International Nuclear Information System (INIS)

Soleille, S.

2004-01-01

RECLAIM is an innovative and ambitious program of emission trading that concerns the nitrogen oxides emitted by stationary sources in the Basin of Los Angeles ( United States). It began in 1994 and suffered from various weaknesses. Faced with the Californian energy crisis during the summer of 2000, it could not overcome it. Some power plants have been ejected from the market and are now regulated by a traditional command-and-control approach. The analysis of the RECLAIM program and a comparison with similar markets enable us to point out the weaknesses that led to RECLAIM partial failure and to give some insight into the future evolution of the other emission trading markets. (author)

Detections of millisecond pulsars with the FERMI Large Area Telescope

International Nuclear Information System (INIS)

Guillemot, L.

2009-09-01

The Fermi observatory was launched on June 11, 2008. It hosts the Large Area Telescope (LAT), sensitive to gamma-ray photons from 20 MeV to over 300 GeV. When the LAT began its activity, nine young and energetic pulsars were known in gamma ray range. At least several tens of pulsar detections by the LAT were predicted before launch. The LAT also allowed the study of millisecond pulsars (MSPs), never firmly detected in gamma ray range before Fermi. This thesis first presents the pulsar timing campaign for the LAT, in collaboration with large radio telescopes and X-ray telescopes, allowing for high sensitivity pulsed searches. Furthermore, it lead to quasi-homogeneous coverage of the galactic MSPs, so that the search for pulsations in LAT data for this population of stars was not affected by an a-priori bias. We present a search for pulsations from these objects in LAT data. For the first time, eight galactic MSPs have been detected as sources of pulsed gamma-ray emission over 100 MeV. In addition, a couple of good candidates for future detection are seen. A similar search for globular cluster MSPs was not successful so far. Comparison of the phase-aligned gamma-ray and radio light curves, as well as the spectral shapes, leads to the conclusion that their gamma-ray emission is similar to that of normal pulsars, and is probably produced in the outer-magnetosphere. This discovery suggests that many unresolved gamma-ray sources are unknown MSPs. (author)

Uso do potencial evocado auditivo de média latência em populações infantis: uma revisão integrativa

Directory of Open Access Journals (Sweden)

Ana Carla Leite Romero

2016-02-01

Full Text Available RESUMO Este estudo teve como objetivo investigar na literatura a utilidade do Potencial evocado auditivo de média latência na população infantil para o estudo do sistema auditivo em seus processos normais e desviantes. A revisão integrativa da literatura científica consistiu na busca de estudos utilizando as bases de dados: PubMed, Scopus e Scielo. Como descritores para a pesquisa foram utilizados os termos: "auditory middle latency response" "auditory middle latency potential" , "children", "child", "childhood", "maturation' e "development". Os estudos eram artigos completos, cujos participantes foram crianças, submetidas ao exame de Potencial evocado auditivo de média latência. A análise dos estudos individualmente verificou aspectos relacionados ao objetivo da pesquisa, a metodologia utilizada e a conclusão de cada estudo. Foram selecionados e lidos na íntegra um total de 11 estudos da base bibliográfica PubMed, oito estudos da Scopus e dois estudos da Scielo. Do total de 21 artigos, seis deles foram realizados com crianças saudáveis, quatro examinaram os componentes desse potencial em crianças com distúrbio de linguagem ou distúrbio específico de linguagem, quatro estudos avaliaram crianças usuárias de implante coclear, e sete crianças com outras alterações. Esta revisão integrativa mostrou a importância da investigação dos potenciais evocados auditivos de média latência em crianças. Tal avaliação vem permitindo um diagnóstico mais precoce e preciso de pacientes com alterações de linguagem, fala ou de aprendizado e de distúrbios do processamento auditivo além do monitoramento de evolução terapêutica.

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.

Science.gov (United States)

Milkereit, Ruth; Persaud, Avinash; Vanoaica, Liviu; Guetg, Adriano; Verrey, Francois; Rotin, Daniela

2015-05-22

Mammalian target of rapamycin 1 (mTORC1), a master regulator of cellular growth, is activated downstream of growth factors, energy signalling and intracellular essential amino acids (EAAs) such as Leu. mTORC1 activation occurs at the lysosomal membrane, and involves V-ATPase stimulation by intra-lysosomal EAA (inside-out activation), leading to activation of the Ragulator, RagA/B-GTP and mTORC1 via Rheb-GTP. How Leu enters the lysosomes is unknown. Here we identified the lysosomal protein LAPTM4b as a binding partner for the Leu transporter, LAT1-4F2hc (SLC7A5-SLAC3A2). We show that LAPTM4b recruits LAT1-4F2hc to lysosomes, leading to uptake of Leu into lysosomes, and is required for mTORC1 activation via V-ATPase following EAA or Leu stimulation. These results demonstrate a functional Leu transporter at the lysosome, and help explain the inside-out lysosomal activation of mTORC1 by Leu/EAA.

X-ray Emission from the Guitar Nebula

OpenAIRE

Romani, Roger W.; Cordes, James M.; Yadigaroglu, I. -A.

1997-01-01

We have detected weak soft X-ray emission from the Pulsar Wind Nebula trailing the high velocity star PSR 2224+65 (the `Guitar Nebula'). This X-ray flux gives evidence of \\gamma~10^7 eV particles in the pulsar wind and constrains the properties of the post-shock flow. The X-ray emission is most easily understood if the shocked pulsar wind is partly confined in the nebula and if magnetic fields in this zone can grow to near equipartition values.

X-Ray Emission from the Guitar Nebula

Science.gov (United States)

Romani, Roger W.; Cordes, James M.; Yadigaroglu, I.-A.

1997-01-01

We have detected weak soft X-ray emission from the pulsar wind nebula trailing the high-velocity star PSR 2224+65 (the "Guitar Nebula"). This X-ray flux gives evidence of gamma approximately 10(exp 7) eV particles in the pulsar wind and constrains the properties of the postshock flow. The X-ray emission is most easily understood if the shocked pulsar wind is partly confined in the nebula and if magnetic fields in this zone can grow to near-equipartition values.

Early MESSENGER Results for Less Abundant or Weakly Emitting Species in Mercury's Exosphere

Science.gov (United States)

Vervack, Ronald J., Jr.; McClintock, William E.; Killen, Rosemary M.; Sprague, Ann L.; Burger, Matthew H.; Merkel, Aimee W.; Sarantos, Menelaos

2011-01-01

Now that the Messenger spacecraft is in orbit about Mercury, the extended observing time enables searches for exospheric species that are less abundant or weakly emitting compared with those for which emission has previously been detected. Many of these species cannot be observed from the ground because of terrestrial atmospheric absorption. We report here on the status of MESSENGER orbital-phase searches for additional species in Mercury's exosphere.

H.E.S.S. discovery of very high energy γ-ray emission from PKS 0625-354

Science.gov (United States)

H.E.S.S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Andersson, T.; Angüner, E. O.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chalme-Calvet, R.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Cui, Y.; Davids, I. D.; Decock, J.; Degrange, B.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hadasch, D.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holler, M.; Horns, D.; Ivascenko, A.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kerszberg, D.; Khélifi, B.; Kieffer, M.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu; Kosack, K.; Krakau, S.; Kraus, M.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morâ, K.; Moulin, E.; Murach, T.; de Naurois, M.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Öttl, S.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.

2018-05-01

PKS 0625-354 (z = 0.055) was observed with the four High Energy Stereoscopic System (H.E.S.S.) telescopes in 2012 during 5.5 h. The source was detected above an energy threshold of 200 GeV at a significance level of 6.1σ. No significant variability is found in these observations. The source is well described with a power-law spectrum with photon index Γ = 2.84 ± 0.50stat ± 0.10syst and normalization (at E0 = 1.0 TeV) N0(E0) = (0.58 ± 0.22stat ± 0.12syst) × 10-12 TeV-1 cm-2 s-1. Multiwavelength data collected with Fermi-LAT, Swift-XRT, Swift-UVOT, ATOM and WISE are also analysed. Significant variability is observed only in the Fermi-LAT γ-ray and Swift-XRT X-ray energy bands. Having a good multiwavelength coverage from radio to very high energy, we performed a broad-band modelling from two types of emission scenarios. The results from a one zone lepto-hadronic and a multizone leptonic models are compared and discussed. On the grounds of energetics, our analysis favours a leptonic multizone model. Models associated to the X-ray variability constraint support previous results, suggesting a BL Lac nature of PKS 0625-354 with, however, a large-scale jet structure typical of a radio galaxy.

Search for sharp and smooth spectral signatures of μνSSM gravitino dark matter with Fermi-LAT

Energy Technology Data Exchange (ETDEWEB)

Gómez-Vargas, Germán A. [Instituto de Astrofísica, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4860, Santiago (Chile); López-Fogliani, Daniel E.; Perez, Andres D. [Instituto de Física de Buenos Aires, UBA and CONICET, Departamento de Física, Facultad de Ciencia Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires (Argentina); Muñoz, Carlos [Departamento de Física Teórica, Universidad Autónoma de Madrid (UAM), Cantoblanco, 28049 Madrid (Spain); De Austri, Roberto Ruiz, E-mail: ggomezv@uc.cl, E-mail: daniel.lopez@df.uba.ar, E-mail: c.munoz@uam.es, E-mail: andres.perez@df.uba.ar, E-mail: rruiz@ific.uv.es [Instituto de Física Corpuscular CSIC-UV, c/Catedrático José Beltrán 2, 46980 Paterna (Valencia) (Spain)

2017-03-01

The μνSSM solves the μ problem of supersymmetric models and reproduces neutrino data, simply using couplings with right-handed neutrinos ν's. Given that these couplings break explicitly R parity, the gravitino is a natural candidate for decaying dark matter in the μνSSM. In this work we carry out a complete analysis of the detection of μνSSM gravitino dark matter through γ-ray observations. In addition to the two-body decay producing a sharp line, we include in the analysis the three-body decays producing a smooth spectral signature. We perform first a deep exploration of the low-energy parameter space of the μνSSM taking into account that neutrino data must be reproduced. Then, we compare the γ-ray fluxes predicted by the model with Fermi -LAT observations. In particular, with the 95% CL upper limits on the total diffuse extragalactic γ-ray background using 50 months of data, together with the upper limits on line emission from an updated analysis using 69.9 months of data. For standard values of bino and wino masses, gravitinos with masses larger than about 4 GeV, or lifetimes smaller than about 10{sup 28} s, produce too large fluxes and are excluded as dark matter candidates. However, when limiting scenarios with large and close values of the gaugino masses are considered, the constraints turn out to be less stringent, excluding masses larger than 17 GeV and lifetimes smaller than 4 × 10{sup 25} s.

Weak mixing below the weak scale in dark-matter direct detection

Science.gov (United States)

Brod, Joachim; Grinstein, Benjamin; Stamou, Emmanuel; Zupan, Jure

2018-02-01

If dark matter couples predominantly to the axial-vector currents with heavy quarks, the leading contribution to dark-matter scattering on nuclei is either due to one-loop weak corrections or due to the heavy-quark axial charges of the nucleons. We calculate the effects of Higgs and weak gauge-boson exchanges for dark matter coupling to heavy-quark axial-vector currents in an effective theory below the weak scale. By explicit computation, we show that the leading-logarithmic QCD corrections are important, and thus resum them to all orders using the renormalization group.

Fermi and Swift Gamma-Ray Burst Afterglow Population Studies

Science.gov (United States)

Racusin, Judith L.; Oates, S. R.; Schady, P.; Burrows, D. N.; dePasquale, M.; Donato, D.; Gehrels, N.; Koch, S.; McEnery, J.; Piran, T.;

Jet Physics of Accreting Super-Massive Black Holes in the Era of the Fermi Gamma-ray Space Telescope

Energy Technology Data Exchange (ETDEWEB)

D' Ammando, Filippo, E-mail: dammando@ira.inaf.it [Dipartimento di Fisica e Astronomia, Universitá di Bologna, Bologna (Italy); Istituto di Radioastronomia (INAF), Bologna (Italy)

2017-11-28

The Fermi Gamma-ray Space Telescope with its main instrument on-board, the Large Area Telescope (LAT), opened a new era in the study of high-energy emission from Active Galactic Nuclei (AGN). When combined with contemporaneous ground- and space-based observations, Fermi-LAT achieves its full capability to characterize the jet structure and the emission mechanisms at work in radio-loud AGN with different black hole mass and accretion rate, from flat spectrum radio quasars to narrow-line Seyfert 1 (NLSy1) galaxies. Here, I discuss important findings regarding the blazar population included in the third LAT catalog of AGN and the γ-ray emitting NLSy1. Moreover, the detection of blazars at redshift beyond three in γ rays allows us to constrain the growth and evolution of heavy black holes over cosmic time, suggesting that the radio-loud phase may be important for a fast black hole growth in the early Universe. Finally, results on extragalactic objects from the third catalog of hard LAT sources are presented.

Jet Physics of Accreting Super-Massive Black Holes in the Era of the Fermi Gamma-ray Space Telescope

Directory of Open Access Journals (Sweden)

Filippo D'Ammando

2017-11-01

Full Text Available The Fermi Gamma-ray Space Telescope with its main instrument on-board, the Large Area Telescope (LAT, opened a new era in the study of high-energy emission from Active Galactic Nuclei (AGN. When combined with contemporaneous ground- and space-based observations, Fermi-LAT achieves its full capability to characterize the jet structure and the emission mechanisms at work in radio-loud AGN with different black hole mass and accretion rate, from flat spectrum radio quasars to narrow-line Seyfert 1 (NLSy1 galaxies. Here, I discuss important findings regarding the blazar population included in the third LAT catalog of AGN and the γ-ray emitting NLSy1. Moreover, the detection of blazars at redshift beyond three in γ rays allows us to constrain the growth and evolution of heavy black holes over cosmic time, suggesting that the radio-loud phase may be important for a fast black hole growth in the early Universe. Finally, results on extragalactic objects from the third catalog of hard LAT sources are presented.

RESOLVING THE BRIGHT HCN(1–0) EMISSION TOWARD THE SEYFERT 2 NUCLEUS OF M51: SHOCK ENHANCEMENT BY RADIO JETS AND WEAK MASING BY INFRARED PUMPING?

International Nuclear Information System (INIS)

Matsushita, Satoki; Trung, Dinh-V-; Boone, Frédéric; Krips, Melanie; Lim, Jeremy; Muller, Sebastien

2015-01-01

We present high angular resolution observations of the HCN(1-0) emission (at ∼1'' or ∼34 pc), together with CO J = 1-0, 2-1, and 3-2 observations, toward the Seyfert 2 nucleus of M51 (NGC 5194). The overall HCN(1-0) distribution and kinematics are very similar to that of the CO lines, which have been indicated as the jet-entrained molecular gas in our past observations. In addition, high HCN(1-0)/CO(1-0) brightness temperature ratio of about unity is observed along the jets, similar to that observed at the shocked molecular gas in our Galaxy. These results strongly indicate that both diffuse and dense gases are entrained by the jets and outflowing from the active galactic nucleus. The channel map of HCN(1-0) at the systemic velocity shows a strong emission right at the nucleus, where no obvious emission has been detected in the CO lines. The HCN(1-0)/CO(1-0) brightness temperature ratio at this region reaches >2, a value that cannot be explained considering standard physical/chemical conditions. Based on our calculations, we suggest infrared pumping and possibly weak HCN masing, but still requiring an enhanced HCN abundance for the cause of this high ratio. This suggests the presence of a compact dense obscuring molecular gas in front of the nucleus of M51, which remains unresolved at our ∼1'' (∼34 pc) resolution, and consistent with the Seyfert 2 classification picture

RESOLVING THE BRIGHT HCN(1–0) EMISSION TOWARD THE SEYFERT 2 NUCLEUS OF M51: SHOCK ENHANCEMENT BY RADIO JETS AND WEAK MASING BY INFRARED PUMPING?

Energy Technology Data Exchange (ETDEWEB)

Matsushita, Satoki [Academia Sinica Institute of Astronomy and Astrophysics, P.O. Box 23-141, Taipei 10617, Taiwan (China); Trung, Dinh-V- [Institute of Physics, Vietnamese Academy of Science and Technology, 10, Daotan, BaDinh, Hanoi (Viet Nam); Boone, Frédéric [Université de Toulouse, UPS-OMP, IRAP, F-31400 Toulouse (France); Krips, Melanie [Institute de Radio Astronomie Millimétrique, 300 Rue de la Piscine, F-38406 Saint Martin d' Hères (France); Lim, Jeremy [Department of Physics, University of Hong Kong, Pokfulam Road (Hong Kong); Muller, Sebastien [Department of Earth and Space Sciences, Chalmers University of Technology, Onsala Space Observatory, SE-43992 Onsala (Sweden)

2015-01-20

We present high angular resolution observations of the HCN(1-0) emission (at ∼1'' or ∼34 pc), together with CO J = 1-0, 2-1, and 3-2 observations, toward the Seyfert 2 nucleus of M51 (NGC 5194). The overall HCN(1-0) distribution and kinematics are very similar to that of the CO lines, which have been indicated as the jet-entrained molecular gas in our past observations. In addition, high HCN(1-0)/CO(1-0) brightness temperature ratio of about unity is observed along the jets, similar to that observed at the shocked molecular gas in our Galaxy. These results strongly indicate that both diffuse and dense gases are entrained by the jets and outflowing from the active galactic nucleus. The channel map of HCN(1-0) at the systemic velocity shows a strong emission right at the nucleus, where no obvious emission has been detected in the CO lines. The HCN(1-0)/CO(1-0) brightness temperature ratio at this region reaches >2, a value that cannot be explained considering standard physical/chemical conditions. Based on our calculations, we suggest infrared pumping and possibly weak HCN masing, but still requiring an enhanced HCN abundance for the cause of this high ratio. This suggests the presence of a compact dense obscuring molecular gas in front of the nucleus of M51, which remains unresolved at our ∼1'' (∼34 pc) resolution, and consistent with the Seyfert 2 classification picture.

Bagging Weak Predictors

DEFF Research Database (Denmark)

Lukas, Manuel; Hillebrand, Eric

Relations between economic variables can often not be exploited for forecasting, suggesting that predictors are weak in the sense that estimation uncertainty is larger than bias from ignoring the relation. In this paper, we propose a novel bagging predictor designed for such weak predictor variab...

Comparação da latência anestésica de Articaína, Lidocaína, Levobupivacaína e Ropivacaína através de 'Pulp Tester'

Directory of Open Access Journals (Sweden)

Anny Caroline Siqueira Britto

Full Text Available INTRODUÇÃO: Um conhecimento profundo dos anestésicos odontológicos, como o tempo de latência da droga, pode assegurar o êxito do controle da dor no trans e no pós-operatório. OBJETIVO: Comparar a latência entre quatro soluções anestésicas, ou seja, o tempo entre o início da deposição do anestésico local e o momento em que seus efeitos tornam-se perceptíveis. Entretanto, isso não está relacionado com o êxito do controle da dor no trans e no pós-operatório (profundidade da anestesia. MATERIAL E MÉTODO: Foi realizado um estudo duplo cego, cruzado e randomizado, com 30 pacientes voluntários submetidos a quatro procedimentos em intervalos de uma semana, a partir de bloqueio do alveolar superior posterior. No segundo molar a ser tratado, foi utilizado o 'pulp tester' em intervalos de 2 minutos, considerando a insensibilidade da polpa quando da ausência de resposta após dois testes consecutivos de 80muV, chegando ao máximo de 10 minutos e determinando, assim, o período de latência do anestésico. Os dados foram submetidos aos testes T-student, de Friedman e de Kruskal-Wallis (p<0,05. RESULTADO: Não houve diferenças estatisticamente significativas (p=0,8327 entre as soluções anestésicas. Para todas estas, a mediana foi 2 minutos. Não houve, ainda, diferenças significantes entre os gêneros em relação à idade (p=0,4545, bem como entre os valores, quando se tentou observar a influência do gênero nos valores de latência (p=0,6754. CONCLUSÃO: Sendo os tempos médios de latência idênticos, a escolha da droga dependerá da duração do procedimento cirúrgico-odontológico a se realizar, além da necessidade ou não de analgesia pós-operatória.

Research on economics and CO2 emission of magnetic and inertial fusion reactors

International Nuclear Information System (INIS)

Mori, Kenjiro; Yamazaki, Kozo; Oishi, Tetsutarou; Arimoto, Hideki; Shoji, Tatsuo

2011-01-01

An economical and environment-friendly fusion reactor system is needed for the realization of attractive power plants. Comparative system studies have been done for magnetic fusion energy (MFE) reactors, and been extended to include inertial fusion energy (IFE) reactors by Physics Engineering Cost (PEC) system code. In this study, we have evaluated both tokamak reactor (TR) and IFE reactor (IR). We clarify new scaling formulas for cost of electricity (COE) and CO 2 emission rate with respect to key design parameters. By the scaling formulas, it is clarified that the plant availability and operation year dependences are especially dominant for COE. On the other hand, the parameter dependences of CO 2 emission rate is rather weak than that of COE. This is because CO 2 emission percentage from manufacturing the fusion island is lower than COE percentage from that. Furthermore, the parameters dependences for IR are rather weak than those for TR. Because the CO 2 emission rate from manufacturing the laser system to be exchanged is very large in comparison with CO 2 emission rate from TR blanket exchanges. (author)

The downside of emissions trading

International Nuclear Information System (INIS)

Viialainen, M.

2004-01-01

High unemployment and redundancies are a major problem in Finland today, and the economic downturn has only intensified as a result of the weak dollar and low investments. The growth of the global economy and the expansion of the EU are likely to see the shift in production and jobs away from Finland to low- cost countries, such as China or the countries of Eastern Central Europe, only intensily. The cost burden imposed by emissions trading will be an added problem. The disproportionally high emission reduction demands placed on Finland within the EU could lead to the loss of as many as 15,000 jobs, according to some estimates

Solar Coronal Events with Extended Hard X-ray and Gamma-ray Emission

Science.gov (United States)

Hudson, H. S.

2017-12-01

A characteristic pattern of solar hard X-ray emission, first identified in SOL1969-03-31 by Frost & Dennis (1971) now has been linked to prolonged high-energy gamma-ray emission detected by the Fermi/LAT experiment, for example in SOL2014-09-01. The distinctive features of these events include flat hard X-ray spectra extending well above 100 keV, a characteristic pattern of time development, low-frequency gyrosynchrotron peaks, CME association, and gamma-rays identifiable with pion decay originating in GeV ions. The identification of these events with otherwise known solar structures nevertheless remains elusive, in spite of the wealth of imagery available from AIA. The quandary is that these events have a clear association with CMEs in the high corona, and yet the gamma-ray production implicates the photosphere itself. The vanishingly small loss cone in the nominal acceleration region makes this extremely difficult. I propose direct inward advection of a part of the SEP particle population, as created on closed field structures, as a possible resolution of this puzzle, and note that this requires retracting magnetic structures on long time scales following the flare itself.

First detection in gamma-rays of a young radio galaxy: Fermi -LAT observations of the compact symmetric object PKS 1718−649

Energy Technology Data Exchange (ETDEWEB)

Migliori, G.; Loh, A.; Corbel, S. [Laboratoire AIM (CEA/IRFU—CNRS/INSU—Université Paris Diderot), CEA DSM/SAp, F-91191 Gif-sur-Yvette (France); Siemiginowska, A.; Sobolewska, M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Ostorero, L. [Dipartimento di Fisica, Università degli Studi di Torino and Istituto Nazionale di Fisica Nucleare (INFN), Via P. Giuria 1, I-10125 Torino (Italy); Stawarz, Ł., E-mail: giulia.migliori@cea.fr [Astronomical Observatory, Jagiellonian University, ul. Orla 171, 30-244 Kraków (Poland)

2016-04-20

We report the γ -ray detection of a young radio galaxy, PKS 1718−649, belonging to the class of compact symmetric objects (CSOs), with the Large Area Telescope (LAT) on board the Fermi satellite. The third Fermi Gamma-ray LAT catalog (3FGL) includes an unassociated γ -ray source, 3FGL J1728.0−6446, located close to PKS 1718−649. Using the latest Pass 8 calibration, we confirm that the best-fit 1 σ position of the γ -ray source is compatible with the radio location of PKS 1718−649. Cross-matching of the γ -ray source position with the positions of blazar sources from several catalogs yields negative results. Thus, we conclude that PKS 1718−649 is the most likely counterpart to the unassociated LAT source. We obtain a detection test statistics TS ∼ 36 (>5 σ ) with a best-fit photon spectral index Γ = 2.9 ± 0.3 and a 0.1–100 GeV photon flux density F {sub 0.1−100} {sub GeV} = (11.5 ± 0.3) × 10{sup −9} ph cm{sup −2} s{sup −1}. We argue that the linear size (∼2 pc), the kinematic age (∼100 years), and the source distance ( z = 0.014) make PKS 1718−649 an ideal candidate for γ -ray detection in the framework of the model proposing that the most compact and the youngest CSOs can efficiently produce GeV radiation via inverse-Compton scattering of the ambient photon fields by the radio lobe non-thermal electrons. Thus, our detection of the source in γ -rays establishes young radio galaxies as a distinct class of extragalactic high-energy emitters and yields a unique insight on the physical conditions in compact radio lobes interacting with the interstellar medium of the host galaxy.

The Of emission lines near 4650 A

International Nuclear Information System (INIS)

Underhill, A.B.; Gilroy, K.K.; Hill, G.M.

1989-01-01

Rectified, normalized, high S/N intensity tracings of nine Of stars were obtained from Reticon spectra in the 4550-4800-A region. The well-known relatively sharp Of emission lines are seen to stand on pedestals of broad weak emission somewhat like the broad emission lines from WR stars. It is suggested that cascades following dielectronic recombination may be an important process driving some lines of N III, C III, and C IV into the emission of Of stars, and that the sharp Of lines come from plasma that is stationary with respect to the star. The broad emission features show an extensive low-density wind from each star. The results imply that the detection of two, more or less equal, broad jumps in the rest spectra of galaxies at about 4640 and 4686 A is more indicative of Of stars than of WR stars. 32 refs

Uptake of 3-[125I]iodo-α-methyl-L-tyrosine into colon cancer DLD-1 cells: characterization and inhibitory effect of natural amino acids and amino acid-like drugs

International Nuclear Information System (INIS)

Shikano, Naoto; Ogura, Masato; Okudaira, Hiroyuki; Nakajima, Syuichi; Kotani, Takashi; Kobayashi, Masato; Nakazawa, Shinya; Baba, Takeshi; Yamaguchi, Naoto; Kubota, Nobuo; Iwamura, Yukio; Kawai, Keiichi

2010-01-01

Introduction: We examined 3-[ 123 I]iodo-α-methyl-L-tyrosine ([ 123 I]IMT) uptake and inhibition by amino acids and amino acid-like drugs in the human DLD-1 colon cancer cell line, to discuss correlation between the inhibition effect and structure. Methods: Expression of relevant neutral amino acid transporters was examined by real-time PCR with DLD-1 cells. The time course of [ 125 I]IMT uptake, contributions of transport systems, concentration dependence and inhibition effects by amino acids and amino acid-like drugs (1 mM) on [ 125 I]IMT uptake were examined. Results: Expression of system L (4F2hc, LAT1 and LAT2), system A (ATA1, ATA2) and system ASC (ASCT1) was strongly detected; system L (LAT3, LAT4) and MCT8 were weakly detected; and B 0 AT was not detected. [ 125 I]IMT uptake in DLD-1 cells involved Na + -independent system L primarily and Na + -dependent system(s). Uptake of [ 125 I]IMT in Na + -free buffer followed Michaelis-Menten kinetics, with a K m of 78 μM and V max of 333 pmol/10 6 cells per minute. Neutral D- and L-amino acids with branched or aromatic large side chains inhibited [ 125 I]IMT uptake. Tyrosine analogues, tryptophan analogues, L-phenylalanine and p-halogeno-L-phenylalanines, and gamma amino acids [including 3,4-dihydroxy-L-phenylalanine (L-DOPA), DL-threo-β-(3,4-dihydroxyphenyl)serine (DOPS), 4-[bis(2-chloroethyl)amino]-L-phenylalanine and 1-(aminomethyl)-cyclohexaneacetic acid] strongly inhibited [ 125 I]IMT uptake, but L-tyrosine methyl ester and R(+)/S(-)-baclofen weakly inhibited uptake. The substrates of system ASC and A did not inhibit [ 125 I]IMT uptake except L-serine and D/L-cysteine. Conclusions: [ 125 I]IMT uptake in DLD-1 cells involves mostly LAT1 and its substrates' (including amino acid-like drugs derived from tyrosine, tryptophan and phenylalanine) affinity to transport via LAT1. Whether transport of gamma amino acid analogues is involved in LAT1 depends on the structure of the group corresponding to the amino acid

Source mechanism of Saturn narrowband emission

Directory of Open Access Journals (Sweden)

J. D. Menietti

2010-04-01

Full Text Available Narrowband emission (NB is observed at Saturn centered near 5 kHz and 20 kHz and harmonics. This emission appears similar in many ways to Jovian kilometric narrowband emission observed at higher frequencies, and therefore may have a similar source mechanism. Source regions of NB near 20 kHz are believed to be located near density gradients in the inner magnetosphere and the emission appears to be correlated with the occurrence of large neutral plasma clouds observed in the Saturn magnetotail. In this work we present the results of a growth rate analysis of NB emission (~20 kHz near or within a probable source region. This is made possible by the sampling of in-situ wave and particle data. The results indicate waves are likely to be generated by the mode-conversion of directly generated Z-mode emission to O-mode near a density gradient. When the local hybrid frequency is close n fce (n is an integer and fce is the electron cyclotron frequency with n=4, 5 or 6 in our case, electromagnetic Z-mode and weak ordinary (O-mode emission can be directly generated by the cyclotron maser instability.

Compatibility between weak gel and microorganisms in weak gel-assisted microbial enhanced oil recovery.

Science.gov (United States)

Qi, Yi-Bin; Zheng, Cheng-Gang; Lv, Cheng-Yuan; Lun, Zeng-Min; Ma, Tao

2018-03-20

To investigate weak gel-assisted microbial flooding in Block Wang Long Zhuang in the Jiangsu Oilfield, the compatibility of weak gel and microbe was evaluated using laboratory experiments. Bacillus sp. W5 was isolated from the formation water in Block Wang Long Zhuang. The rate of oil degradation reached 178 mg/day, and the rate of viscosity reduction reached 75.3%. Strain W5 could produce lipopeptide with a yield of 1254 mg/L. Emulsified crude oil was dispersed in the microbial degradation system, and the average diameter of the emulsified oil particles was 18.54 μm. Bacillus sp. W5 did not affect the rheological properties of the weak gel, and the presence of the weak gel did not significantly affect bacterial reproduction (as indicated by an unchanged microbial biomass), emulsification (surface tension is 35.56 mN/m and average oil particles size is 21.38 μm), oil degradation (162 mg/day) and oil viscosity reduction (72.7%). Core-flooding experiments indicated oil recovery of 23.6% when both weak gel and Bacillus sp. W5 were injected into the system, 14.76% when only the weak gel was injected, and 9.78% with strain W5 was injected without the weak gel. The results demonstrate good compatibility between strains W5 and the weak gel and highlight the application potential of weak gel-assisted microbial flooding. Copyright © 2018 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

History of Weak Interactions

Science.gov (United States)

Lee, T. D.

1970-07-01

While the phenomenon of beta-decay was discovered near the end of the last century, the notion that the weak interaction forms a separate field of physical forces evolved rather gradually. This became clear only after the experimental discoveries of other weak reactions such as muon-decay, muon-capture, etc., and the theoretical observation that all these reactions can be described by approximately the same coupling constant, thus giving rise to the notion of a universal weak interaction. Only then did one slowly recognize that the weak interaction force forms an independent field, perhaps on the same footing as the gravitational force, the electromagnetic force, and the strong nuclear and sub-nuclear forces.

Weakly nonlocal symplectic structures, Whitham method and weakly nonlocal symplectic structures of hydrodynamic type

International Nuclear Information System (INIS)

Maltsev, A Ya

2005-01-01

We consider the special type of field-theoretical symplectic structures called weakly nonlocal. The structures of this type are, in particular, very common for integrable systems such as KdV or NLS. We introduce here the special class of weakly nonlocal symplectic structures which we call weakly nonlocal symplectic structures of hydrodynamic type. We investigate then the connection of such structures with the Whitham averaging method and propose the procedure of 'averaging' the weakly nonlocal symplectic structures. The averaging procedure gives the weakly nonlocal symplectic structure of hydrodynamic type for the corresponding Whitham system. The procedure also gives 'action variables' corresponding to the wave numbers of m-phase solutions of the initial system which give the additional conservation laws for the Whitham system

Deriving the Contribution of Blazars to the Fermi-LAT Extragalactic γ-ray Background at E > 10 GeV with Efficiency Corrections and Photon Statistics

Science.gov (United States)

Di Mauro, M.; Manconi, S.; Zechlin, H.-S.; Ajello, M.; Charles, E.; Donato, F.

2018-04-01

The Fermi Large Area Telescope (LAT) Collaboration has recently released the Third Catalog of Hard Fermi-LAT Sources (3FHL), which contains 1556 sources detected above 10 GeV with seven years of Pass 8 data. Building upon the 3FHL results, we investigate the flux distribution of sources at high Galactic latitudes (| b| > 20^\\circ ), which are mostly blazars. We use two complementary techniques: (1) a source-detection efficiency correction method and (2) an analysis of pixel photon count statistics with the one-point probability distribution function (1pPDF). With the first method, using realistic Monte Carlo simulations of the γ-ray sky, we calculate the efficiency of the LAT to detect point sources. This enables us to find the intrinsic source-count distribution at photon fluxes down to 7.5 × 10‑12 ph cm‑2 s‑1. With this method, we detect a flux break at (3.5 ± 0.4) × 10‑11 ph cm‑2 s‑1 with a significance of at least 5.4σ. The power-law indexes of the source-count distribution above and below the break are 2.09 ± 0.04 and 1.07 ± 0.27, respectively. This result is confirmed with the 1pPDF method, which has a sensitivity reach of ∼10‑11 ph cm‑2 s‑1. Integrating the derived source-count distribution above the sensitivity of our analysis, we find that (42 ± 8)% of the extragalactic γ-ray background originates from blazars.

Broadband pulsations from PSR B1821–24: Implications for emission models and the pulsar population of M28

Energy Technology Data Exchange (ETDEWEB)

Johnson, T. J. [National Research Council Research Associate, National Academy of Sciences, Washington, DC 20001 (United States); Guillemot, L.; Freire, P. C. C. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Kerr, M.; Romani, R. W.; Wood, M. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Cognard, I. [Laboratoire de Physique et Chimie de l' Environnement, LPCE UMR 6115 CNRS, F-45071 Orléans Cedex 02 (France); Ray, P. S.; Wolff, M. T.; Grove, J. E.; Cheung, C. C. [Space Science Division, Naval Research Laboratory, Washington, DC 20375-5352 (United States); Bégin, S. [Département de physique, génie physique et optique, Université Laval, Québec (Canada); Janssen, G. H.; Espinoza, C. M. [Jodrell Bank Centre for Astrophysics, School of Physics and Astronomy, The University of Manchester, Manchester M13 9PL (United Kingdom); Venter, C. [Centre for Space Research, North-West University, Potchefstroom Campus, Private Bag X6001, 2520 Potchefstroom (South Africa); Casandjian, J. M. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d' Astrophysique, CEA Saclay, 91191 Gif sur Yvette (France); Stairs, I. H. [Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); Camilo, F. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Ferrara, E. C.; Harding, A. K., E-mail: tyrel.j.johnson@gmail.com, E-mail: guillemo@mpifr-bonn.mpg.de, E-mail: kerrm@stanford.edu, E-mail: icognard@cnrs-orleans.fr, E-mail: Paul.Ray@nrl.navy.mil [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); and others

2013-12-01

We report a 5.4σ detection of pulsed gamma rays from PSR B1821–24 in the globular cluster M28 using ∼44 months of Fermi Large Area Telescope (LAT) data that have been reprocessed with improved instrument calibration constants. We constructed a phase-coherent ephemeris, with post-fit residual rms of 3 μs, using radio data spanning ∼23.2 yr, enabling measurements of the multi-wavelength light-curve properties of PSR B1821–24 at the milliperiod level. We fold RXTE observations of PSR B1821–24 from 1996 to 2007 and discuss implications on the emission zones. The gamma-ray light curve consists of two peaks separated by 0.41 ± 0.02 in phase, with the first gamma-ray peak lagging behind the first radio peak by 0.05 ± 0.02 in phase, consistent with the phase of giant radio pulses. We observe significant emission in the off-peak interval of PSR B1821–24 with a best-fit LAT position inconsistent with the core of M28. We do not detect significant gamma-ray pulsations at the spin or orbital periods from any other known pulsar in M28, and we place limits on the number of energetic pulsars in the cluster. The derived gamma-ray efficiency, ∼2%, is typical of other gamma-ray pulsars with comparable spin-down power, suggesting that the measured spin-down rate (2.2 × 10{sup 36} erg s{sup –1}) is not appreciably distorted by acceleration in the cluster potential. This confirms PSR B1821–24 as the second very energetic millisecond pulsar in a globular cluster and raises the question of whether these represent a separate class of objects that only form in regions of very high stellar density.

Processamento auditivo: comparação entre potenciais evocados auditivos de média latência e testes de padrões temporais Auditory processing: comparision between auditory middle latency response and temporal pattern tests

Directory of Open Access Journals (Sweden)

Eliane Schochat

2009-06-01

Full Text Available OBJETIVO: verificar a concordância entre os resultados da avaliação do Potencial Evocado Auditivo de Média Latência e testes de padrões temporais. MÉTODOS: foram avaliados 155 sujeitos de ambos os sexos, idade entre sete e 16 anos, com audição periférica normal. Os sujeitos foram submetidos aos testes de Padrão de Frequência e Duração e Potenciais Evocados auditivos de Média Latência. RESULTADOS: os sujeitos foram distribuídos em dois grupos: normal ou alterado para o processamento auditivo. O índice de alteração foi em torno de 30%, exceto para Potencial Evocado Auditivo de Média Latência que foi pouco menor (17,4%. Os padrões de frequência e duração foram concordantes até 12 anos. A partir dos 13 anos, observou-se maior ocorrência de alteração no padrão de frequência que no padrão de duração. Os padrões de frequência e duração (orelhas direita e esquerda e Potencial Evocado Auditivo de Média Latência não foram concordantes. Para 7 e 8 anos a combinação padrão de frequência e duração normal / Média Latência alterado tem maior ocorrência que a combinação padrão de frequência e duração alterada / Média Latência normal. Nas demais idades, ocorreu o contrário. Não houve diferença estatística entre as faixas etárias quanto à distribuição de normal e alterado no padrão de frequência (orelhas direita e esquerda, nem para o Potencial Evocado Auditivo de Média Latência, com exceção do padrão de duração para o grupo de 9 e 10 anos. CONCLUSÃO: não houve concordância entre os resultados do Potencial Evocado Auditivo de Média Latência e os testes de padrões temporais aplicados.PURPOSE: to check the concordance between the Middle Latency Response and temporal processing tests. METHODS: 155 normal hearing subjects of both genders (age group range between 7 to 16 years were evaluated with the Pitch and Duration Pattern Tests (behavioral and Middle Latency Response

Search for gamma-ray spectral lines with the Fermi Large Area Telescope and dark matter implications

Energy Technology Data Exchange (ETDEWEB)

Ackermann, M.; Ajello, M.; Albert, A.; Allafort, A.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Bissaldi, E.; Bloom, E. D.; Bonamente, E.; Bottacini, E.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Casandjian, J. M.; Cecchi, C.; Charles, E.; Chaves, R. C. G.; Chekhtman, A.; Chiang, J.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Cutini, S.; D’Ammando, F.; de Angelis, A.; de Palma, F.; Dermer, C. D.; Digel, S. W.; Di Venere, L.; Drell, P. S.; Drlica-Wagner, A.; Essig, R.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Focke, W. B.; Franckowiak, A.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Germani, S.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Gomez-Vargas, G. A.; Grenier, I. A.; Guiriec, S.; Gustafsson, M.; Hadasch, D.; Hayashida, M.; Hill, A. B.; Horan, D.; Hou, X.; Hughes, R. E.; Inoue, Y.; Izaguirre, E.; Jogler, T.; Kamae, T.; Knödlseder, J.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Longo, F.; Loparco, F.; Lovellette, M. N.; Lubrano, P.; Malyshev, D.; Mayer, M.; Mazziotta, M. N.; McEnery, J. E.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nakamori, T.; Nemmen, R.; Nuss, E.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orienti, M.; Orlando, E.; Ormes, J. F.; Paneque, D.; Perkins, J. S.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Rainò, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Romani, R. W.; Sánchez-Conde, M.; Schulz, A.; Sgrò, C.; Siegal-Gaskins, J.; Siskind, E. J.; Snyder, A.; Spandre, G.; Spinelli, P.; Suson, D. J.; Tajima, H.; Takahashi, H.; Thayer, J. G.; Thayer, J. B.; Tibaldo, L.; Tinivella, M.; Tosti, G.; Troja, E.; Uchiyama, Y.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Winer, B. L.; Wood, K. S.; Wood, M.; Yang, Z.; Zaharijas, G.; Zimmer, S.

2013-10-22

Weakly interacting massive particles (WIMPs) are a theoretical class of particles that are excellent dark matter candidates. WIMP annihilation or decay may produce essentially monochromatic γ rays detectable by the Fermi Large Area Telescope (LAT) against the astrophysical γ -ray emission of the Galaxy. We have searched for spectral lines in the energy range 5–300 GeV using 3.7 years of data, reprocessed with updated instrument calibrations and an improved energy dispersion model compared to the previous Fermi-LAT Collaboration line searches. We searched in five regions selected to optimize sensitivity to different theoretically motivated dark matter density distributions. We did not find any globally significant lines in our a priori search regions and present 95% confidence limits for annihilation cross sections of self-conjugate WIMPs and decay lifetimes. Our most significant fit occurred at 133 GeV in our smallest search region and had a local significance of 3.3 standard deviations, which translates to a global significance of 1.5 standard deviations. We discuss potential systematic effects in this search, and examine the feature at 133 GeV in detail. We find that the use both of reprocessed data and of additional information in the energy dispersion model contributes to the reduction in significance of the linelike feature near 130 GeV relative to significances reported in other works. We also find that the feature is narrower than the LAT energy resolution at the level of 2 to 3 standard deviations, which somewhat disfavors the interpretation of the 133 GeV feature as a real WIMP signal.

Liability rules for international trading of greenhouse gas emissions quotas

DEFF Research Database (Denmark)

Haites, E.; Missfeldt, F.

2001-01-01

To reduce the costs of mitigating greenhouse gas emissions in accordance with the Kyoto protocol, international trades of emissions quotas are allowed. The revenue from the sale of quotas may exceed the sanctions for non-compliance if these penalties are weak or poorly enforced. Under...... these circumstances emissions trading enables a country to benefit financially through non-compliance. To counter non-compliance due to trading a range of liability proposals have been suggested. Using a simple global model, we analyze the economic and environmental performance of these proposals for the first...

Weak interactions

International Nuclear Information System (INIS)

Bjorken, J.D.

1978-01-01

Weak interactions are studied from a phenomenological point of view, by using a minimal number of theoretical hypotheses. Charged-current phenomenology, and then neutral-current phenomenology are discussed. This all is described in terms of a global SU(2) symmetry plus an electromagnetic correction. The intermediate-boson hypothesis is introduced and lower bounds on the range of the weak force are inferred. This phenomenology does not yet reconstruct all the predictions of the conventional SU(2)xU(1) gauge theory. To do that requires an additional assumption of restoration of SU(2) symmetry at asymptotic energies

Systematic review: role of acid, weakly acidic and weakly alkaline reflux in gastro-oesophageal reflux disease

NARCIS (Netherlands)

Boeckxstaens, G. E.; Smout, A.

2010-01-01

The importance of weakly acidic and weakly alkaline reflux in gastro-oesophageal reflux disease (GERD) is gaining recognition. To quantify the proportions of reflux episodes that are acidic (pH <4), weakly acidic (pH 4-7) and weakly alkaline (pH >7) in adult patients with GERD, and to evaluate their

Weakly infinite-dimensional spaces

International Nuclear Information System (INIS)

Fedorchuk, Vitalii V

2007-01-01

In this survey article two new classes of spaces are considered: m-C-spaces and w-m-C-spaces, m=2,3,...,∞. They are intermediate between the class of weakly infinite-dimensional spaces in the Alexandroff sense and the class of C-spaces. The classes of 2-C-spaces and w-2-C-spaces coincide with the class of weakly infinite-dimensional spaces, while the compact ∞-C-spaces are exactly the C-compact spaces of Haver. The main results of the theory of weakly infinite-dimensional spaces, including classification via transfinite Lebesgue dimensions and Luzin-Sierpinsky indices, extend to these new classes of spaces. Weak m-C-spaces are characterised by means of essential maps to Henderson's m-compacta. The existence of hereditarily m-strongly infinite-dimensional spaces is proved.

FAST's Discovery of a New Millisecond Pulsar (MSP) toward the Fermi-LAT unassociated source 3FGL J0318.1+0252

Science.gov (United States)

Wang, Pei; Li, Di; Zhu, Weiwei; Zhang, Chengmin; Yan, Jun; Hou, Xian; Clark, Colin J.; Saz Parkinson, Pablo M.; Michelson, Peter F.; Ferrara, Elizabeth C.; Thompson, David J.; Smith, David A.; Ray, Paul S.; Kerr, Matthew; Shen, Zhiqiang; Wang, Na; Fermi-LAT Collaboration

2018-04-01

The Five hundred-meter Aperture Spherical radio Telescope (FAST), operated by the National Astronomical Observatories, Chinese Academy of Sciences, has discovered a radio millisecond pulsar (MSP) coincident with the unassociated gamma-ray source 3FGL J0318.1+0252 (Acero et al. 2015 ApJS, 218, 23), also known as FL8Y J0318.2+0254 in the recently released Fermi Large Area Telescope (LAT) 8-year Point Source List (FL8Y).

Acute muscular weakness in children

Directory of Open Access Journals (Sweden)

Ricardo Pablo Javier Erazo Torricelli

Full Text Available ABSTRACT Acute muscle weakness in children is a pediatric emergency. During the diagnostic approach, it is crucial to obtain a detailed case history, including: onset of weakness, history of associated febrile states, ingestion of toxic substances/toxins, immunizations, and family history. Neurological examination must be meticulous as well. In this review, we describe the most common diseases related to acute muscle weakness, grouped into the site of origin (from the upper motor neuron to the motor unit. Early detection of hyperCKemia may lead to a myositis diagnosis, and hypokalemia points to the diagnosis of periodic paralysis. Ophthalmoparesis, ptosis and bulbar signs are suggestive of myasthenia gravis or botulism. Distal weakness and hyporeflexia are clinical features of Guillain-Barré syndrome, the most frequent cause of acute muscle weakness. If all studies are normal, a psychogenic cause should be considered. Finding the etiology of acute muscle weakness is essential to execute treatment in a timely manner, improving the prognosis of affected children.

MODELING THE EARLY AFTERGLOW IN THE SHORT AND HARD GRB 090510

Energy Technology Data Exchange (ETDEWEB)

Fraija, N.; Lee, W. H. [Instituto de Astronomía, Universidad Nacional Autónoma de México, Apdo. Postal 70-264, Cd. Universitaria, 04510 Ciudad de México, DF (Mexico); Veres, P. [Center for Space Plasma and Aeronomic Research (CSPAR), University of Alabama in Huntsville, Huntsville, AL 35899 (United States); Duran, R. Barniol, E-mail: nifraija@astro.unam.mx, E-mail: wlee@astro.unam.mx, E-mail: pv0004@uah.edu, E-mail: rbarniol@purdue.edu [Department of Physics and Astronomy, Purdue University, 525 Northwestern Avenue, West Lafayette, IN 47907 (United States)

2016-11-01

The bright, short, and hard GRB 090510 was detected by all instruments aboard the Fermi and Swift satellites. The multiwavelength observations of this burst presented similar features to the Fermi -LAT-detected gamma-ray bursts. In the framework of the external shock model of early afterglow, a leptonic scenario that evolves in a homogeneous medium is proposed to revisit GRB 090510 and explain the multiwavelength light curve observations presented in this burst. These observations are consistent with the evolution of a jet before and after the jet break. The long-lasting LAT, X-ray, and optical fluxes are explained in the synchrotron emission from the adiabatic forward shock. Synchrotron self-Compton emission from the reverse shock is consistent with the bright LAT peak provided that the progenitor environment is entrained with strong magnetic fields. It could provide compelling evidence of magnetic field amplification in the neutron star merger.

Weak openness and almost openness

Directory of Open Access Journals (Sweden)

David A. Rose

1984-01-01

Full Text Available Weak openness and almost openness for arbitrary functions between topological spaces are defined as duals to the weak continuity of Levine and the almost continuity of Husain respectively. Independence of these two openness conditions is noted and comparison is made between these and the almost openness of Singal and Singal. Some results dual to those known for weak continuity and almost continuity are obtained. Nearly almost openness is defined and used to obtain an improved link from weak continuity to almost continuity.

Weak values in collision theory

Science.gov (United States)

de Castro, Leonardo Andreta; Brasil, Carlos Alexandre; Napolitano, Reginaldo de Jesus

2018-05-01

Weak measurements have an increasing number of applications in contemporary quantum mechanics. They were originally described as a weak interaction that slightly entangled the translational degrees of freedom of a particle to its spin, yielding surprising results after post-selection. That description often ignores the kinetic energy of the particle and its movement in three dimensions. Here, we include these elements and re-obtain the weak values within the context of collision theory by two different approaches, and prove that the results are compatible with each other and with the results from the traditional approach. To provide a more complete description, we generalize weak values into weak tensors and use them to provide a more realistic description of the Stern-Gerlach apparatus.

Electromagnetic current in weak interactions

International Nuclear Information System (INIS)

Ma, E.

1983-01-01

In gauge models which unify weak and electromagnetic interactions, the weak neutral-current interaction also involves the electromagnetic current. The exact nature of such a component can be explored using e + e - experimental data. In recent years, the existence of a new component of the weak interaction has become firmly established, i.e., the neutral-current interaction. As such, it competes with the electromagnetic interaction whenever the particles involved are also charged, but at a very much lower rate because its effective strength is so small. Hence neutrino processes are best for the detection of the neutral-current interaction. However, in any gauge model which unifies weak and electromagnetic interactions, the weak neutral-current interaction also involves the electromagnetic current

Effects of decoupling of carbon dioxide emission by Chinese nonferrous metals industry

International Nuclear Information System (INIS)

Ren Shenggang; Hu Zhen

2012-01-01

We adopted the refined Laspeyres index approach to explore the impacts of industry scale, energy mix, energy intensity and utility mix on the total carbon dioxide emissions from the Chinese nonferrous metals industry for the period 1996–2008. In addition, we calculated the trend of decoupling effects in nonferrous metals industry in China by presenting a theoretical framework for decoupling. As the results suggest, Chinese nonferrous metals industry has gone through four decoupling stages: strong negative decoupling stage (1996–1998), weak decoupling stage (1999–2000), expensive negative decoupling stage (2001–2003) and weak decoupling stage (2004–2008). We have analyzed the reasons for each phase. Generally speaking, the rapid growth of the industry is the most important factor responsible for the increase of CO 2 emissions, and the change in energy mix was mainly due to the increased proportion of electric energy consumption that has contributed to the increase of CO 2 emissions. Reduction of energy intensity has contributed significantly to emissions decrease, and the utility mix effect has also contributed to the emission decrease to some extent. - Highlights: ► We calculate the decoupling effects of CO 2 from Chinese nonferrous metals industry. ► Results demonstrate that the industry has gone through four decoupling stages. ► The output effect is most important for the increase of CO 2 emissions. ► Reduction of energy intensity has contributed significantly to emissions decrease.

Weak interactions with nuclei

International Nuclear Information System (INIS)

Walecka, J.D.

1983-01-01

Nuclei provide systems where the strong, electomagnetic, and weak interactions are all present. The current picture of the strong interactions is based on quarks and quantum chromodynamics (QCD). The symmetry structure of this theory is SU(3)/sub C/ x SU(2)/sub W/ x U(1)/sub W/. The electroweak interactions in nuclei can be used to probe this structure. Semileptonic weak interactions are considered. The processes under consideration include beta decay, neutrino scattering and weak neutral-current interactions. The starting point in the analysis is the effective Lagrangian of the Standard Model

An explorative study of non-invasive ultra-weak photon emission and the anti-oxidative influence of oral zinc sulphate in light-sensitive patients with erythropoietic protoporphyria

DEFF Research Database (Denmark)

Petersen, Anita Birgit; Philipsen, Peter Alshede; Wulf, Hans Christian

2011-01-01

BACKGROUND: Erythropoietic protoporphyria (EPP) is a rare, inherited disorder of haem biosynthesis owing to deficient ferrochelatase (FECH) and accumulation of protoporphyrin IX (PPIX). This results in acute cutaneous photosensitivity upon light exposure with production of reactive oxygen species...... correlation was found between plasma zinc concentration and the initial burst. CONCLUSION: Measurements of UPE can be used for monitoring UVA-induced oxidative processes in vivo in the skin of EPP patients....... (ROS) and ultra-weak photon emission (UPE) as a by-product. We investigated if UPE evaluated the light sensitivity in EPP patients and influence of zinc treatment. METHODS: Fourteen EPP patients took zinc sulphate (3 × 200 mg/day) during spring and summer. Using a photomultiplier (PM), UPE was measured...... from the buttock skin and dorsal hand before and after solar-simulated light (SUN) exposure. Blood samples were analysed routinely for plasma zinc, iron, ferritin, transferrin, haemoglobin, erythrocyte PPIX and Zn-PPIX. RESULTS: UPE in EPP patients resembled that seen in healthy individuals. Without...

Bayesian Markov Chain Monte Carlo inversion for weak anisotropy parameters and fracture weaknesses using azimuthal elastic impedance

Science.gov (United States)

Chen, Huaizhen; Pan, Xinpeng; Ji, Yuxin; Zhang, Guangzhi

2017-08-01

A system of aligned vertical fractures and fine horizontal shale layers combine to form equivalent orthorhombic media. Weak anisotropy parameters and fracture weaknesses play an important role in the description of orthorhombic anisotropy (OA). We propose a novel approach of utilizing seismic reflection amplitudes to estimate weak anisotropy parameters and fracture weaknesses from observed seismic data, based on azimuthal elastic impedance (EI). We first propose perturbation in stiffness matrix in terms of weak anisotropy parameters and fracture weaknesses, and using the perturbation and scattering function, we derive PP-wave reflection coefficient and azimuthal EI for the case of an interface separating two OA media. Then we demonstrate an approach to first use a model constrained damped least-squares algorithm to estimate azimuthal EI from partially incidence-phase-angle-stack seismic reflection data at different azimuths, and then extract weak anisotropy parameters and fracture weaknesses from the estimated azimuthal EI using a Bayesian Markov Chain Monte Carlo inversion method. In addition, a new procedure to construct rock physics effective model is presented to estimate weak anisotropy parameters and fracture weaknesses from well log interpretation results (minerals and their volumes, porosity, saturation, fracture density, etc.). Tests on synthetic and real data indicate that unknown parameters including elastic properties (P- and S-wave impedances and density), weak anisotropy parameters and fracture weaknesses can be estimated stably in the case of seismic data containing a moderate noise, and our approach can make a reasonable estimation of anisotropy in a fractured shale reservoir.

Systematic search for very-high-energy gamma-ray emission from bow shocks of runaway stars

Science.gov (United States)

H.E.S.S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Andersson, T.; Angüner, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chalme-Calvet, R.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Chrétien, M.; Coffaro, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Cui, Y.; Davids, I. D.; Decock, J.; Degrange, B.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O.'C.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; Kieffer, M.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Öttl, S.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Richter, S.; Rieger, F.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Saito, S.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stycz, K.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.

2018-04-01

Context. Runaway stars form bow shocks by ploughing through the interstellar medium at supersonic speeds and are promising sources of non-thermal emission of photons. One of these objects has been found to emit non-thermal radiation in the radio band. This triggered the development of theoretical models predicting non-thermal photons from radio up to very-high-energy (VHE, E ≥ 0.1 TeV) gamma rays. Subsequently, one bow shock was also detected in X-ray observations. However, the data did not allow discrimination between a hot thermal and a non-thermal origin. Further observations of different candidates at X-ray energies showed no evidence for emission at the position of the bow shocks either. A systematic search in the Fermi-LAT energy regime resulted in flux upper limits for 27 candidates listed in the E-BOSS catalogue. Aim. Here we perform the first systematic search for VHE gamma-ray emission from bow shocks of runaway stars. Methods: Using all available archival H.E.S.S. data we search for very-high-energy gamma-ray emission at the positions of bow shock candidates listed in the second E-BOSS catalogue release. Out of the 73 bow shock candidates in this catalogue, 32 have been observed with H.E.S.S. Results: None of the observed 32 bow shock candidates in this population study show significant emission in the H.E.S.S. energy range. Therefore, flux upper limits are calculated in five energy bins and the fraction of the kinetic wind power that is converted into VHE gamma rays is constrained. Conclusions: Emission from stellar bow shocks is not detected in the energy range between 0.14 and 18 TeV.The resulting upper limits constrain the level of VHE gamma-ray emission from these objects down to 0.1-1% of the kinetic wind energy.

Bright emission lines in new Seyfert galaxies

International Nuclear Information System (INIS)

Afanasev, V.L.; Denisiuk, E.K.; Lipovetskii, V.A.; Shapovalova, A.I.

1983-01-01

Observational data are given on bright emission lines (H-alpha, H-beta, and forbidden N II, S II, and O III) for 14 recently discovered Seyfert galaxies. The investigated objects can be divided into three groups, which correspond approximately to the first (5 objects), the intermediate (4 objects), and the second (4 objects) Seyfert types. Attention is drawn to the properties of the galaxy Markaryan 1018, which has features of both the first and the second type and is distinguished by the weakness of its emission lines, which is probably due to a gas deficit. 7 references

ORIGIN OF 12 μm EMISSION ACROSS GALAXY POPULATIONS FROM WISE AND SDSS SURVEYS

International Nuclear Information System (INIS)

Donoso, E.; Yan Lin; Tsai, C.; Eisenhardt, P.; Stern, D.; Assef, R. J.; Leisawitz, D.; Jarrett, T. H.; Stanford, S. A.

2012-01-01

We cross-matched Wide-field Infrared Survey Explorer sources brighter than 1 mJy at 12 μm with the Sloan Digital Sky Survey galaxy spectroscopic catalog to produce a sample of ∼10 5 galaxies at (z) = 0.08, the largest of its kind. This sample is dominated (70%) by star-forming (SF) galaxies from the blue sequence, with total IR luminosities in the range ∼10 8 -10 12 L ☉ . We identify which stellar populations are responsible for most of the 12 μm emission. We find that most (∼80%) of the 12 μm emission in SF galaxies is produced by stellar populations younger than 0.6 Gyr. In contrast, the 12 μm emission in weak active galactic nuclei (AGNs; L [Oiii] 7 L . ) is produced by older stars, with ages of ∼1-3 Gyr. We find that L 12μm linearly correlates with stellar mass for SF galaxies. At fixed 12 μm luminosity, weak AGNs deviate toward higher masses since they tend to be hosted by massive, early-type galaxies with older stellar populations. SF galaxies and weak AGNs follow different L 12μm -SFR (star formation rate) relations, with weak AGNs showing excess 12 μm emission at low SFR (0.02-1 M ☉ yr –1 ). This is likely due to dust grains heated by older stars. While the specific star formation rate (SSFR) of SF galaxies is nearly constant, the SSFR of weak AGNs decreases by ∼3 orders of magnitude, reflecting the very different star formation efficiencies between SF galaxies and massive, early-type galaxies. Stronger type II AGNs in our sample (L[ Oiii] > 10 7 L . ), act as an extension of massive SF galaxies, connecting the SF and weak AGN sequences. This suggests a picture where galaxies form stars normally until an AGN (possibly after a starburst episode) starts to gradually quench the SF activity. We also find that 4.6-12 μm color is a useful first-order indicator of SF activity in a galaxy when no other data are available.

Extended Gamma-Ray Emission from the G25.0+0.0 Region: A Star-forming Region Powered by the Newly Found OB Association?

Energy Technology Data Exchange (ETDEWEB)

Katsuta, J. [Department of Physical Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Uchiyama, Y. [Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501 (Japan); Funk, S., E-mail: katsuta@hep01.hepl.hiroshima-u.ac.jp [Erlangen Centre for Astroparticle Physics, D-91058 Erlangen (Germany)

2017-04-20

We report a study of extended γ -ray emission with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope , which is likely to be the second case of a γ -ray detection from a star-forming region (SFR) in our Galaxy. The LAT source is located in the G25 region, 1.°7 × 2.°1 around ( l , b ) = (25.°0, 0.°0). The γ -ray emission is found to be composed of two extended sources and one pointlike source. The extended sources have similar sizes of about 1.°4 × 0.°6. An ∼0.°4 diameter subregion of one has a photon index of Γ = 1.53 ± 0.15, and is spatially coincident with HESS J1837−069, likely a pulsar wind nebula. The other parts of the extended sources have a photon index of Γ = 2.1 ± 0.2 without significant spectral curvature. Given their spatial and spectral properties, they have no clear associations with sources at other wavelengths. Their γ -ray properties are similar to those of the Cygnus cocoon SFR, the only firmly established γ -ray detection of an SFR in the Galaxy. Indeed, we find bubble-like structures of atomic and molecular gas in G25, which may be created by a putative OB association/cluster. The γ -ray emitting regions appear confined in the bubble-like structure; similar properties are also found in the Cygnus cocoon. In addition, using observations with the XMM-Newton , we find a candidate young massive OB association/cluster G25.18+0.26 in the G25 region. We propose that the extended γ -ray emission in G25 is associated with an SFR driven by G25.18+0.26. Based on this scenario, we discuss possible acceleration processes in the SFR and compare them with the Cygnus cocoon.

Weak C* Hopf Symmetry

OpenAIRE

Rehren, K. -H.

1996-01-01

Weak C* Hopf algebras can act as global symmetries in low-dimensional quantum field theories, when braid group statistics prevents group symmetries. Possibilities to construct field algebras with weak C* Hopf symmetry from a given theory of local observables are discussed.

PLASMA EMISSION BY COUNTER-STREAMING ELECTRON BEAMS

Energy Technology Data Exchange (ETDEWEB)

Ziebell, L. F.; Petruzzellis, L. T.; Gaelzer, R. [Instituto de Física, UFRGS, Porto Alegre, RS (Brazil); Yoon, P. H. [Institute for Physical Science and Technology, University of Maryland, College Park, MD (United States); Pavan, J., E-mail: luiz.ziebell@ufrgs.br, E-mail: yoonp@umd.edu, E-mail: joel.pavan@ufpel.edu.br [Instituto de Física e Matemática, UFPel, Pelotas, RS (Brazil)

2016-02-10

The radiation emission mechanism responsible for both type-II and type-III solar radio bursts is commonly accepted as plasma emission. Recently Ganse et al. suggested that type-II radio bursts may be enhanced when the electron foreshock geometry of a coronal mass ejection contains a double hump structure. They reasoned that the counter-streaming electron beams that exist between the double shocks may enhance the nonlinear coalescence interaction, thereby giving rise to more efficient generation of radiation. Ganse et al. employed a particle-in-cell simulation to study such a scenario. The present paper revisits the same problem with EM weak turbulence theory, and show that the fundamental (F) emission is not greatly affected by the presence of counter-streaming beams, but the harmonic (H) emission becomes somewhat more effective when the two beams are present. The present finding is thus complementary to the work by Ganse et al.

Gamma-Ray Observations of Tycho’s Supernova Remnant with VERITAS and Fermi

Energy Technology Data Exchange (ETDEWEB)

Archambault, S.; Bourbeau, E.; Feng, Q.; Griffin, S. [Physics Department, McGill University, Montreal, QC H3A 2T8 (Canada); Archer, A.; Buckley, J. H.; Bugaev, V.; Errando, M. [Department of Physics, Washington University, St. Louis, MO 63130 (United States); Benbow, W.; Cerruti, M. [Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645 (United States); Bird, R.; Buchovecky, M. [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095 (United States); Connolly, M. P. [School of Physics, National University of Ireland Galway, University Road, Galway (Ireland); Cui, W.; Finley, J. P. [Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907 (United States); Dwarkadas, V. V. [Department of Astronomy and Astrophysics, University of Chicago, Chicago, IL 60637 (United States); Falcone, A. [Department of Astronomy and Astrophysics, 525 Davey Lab, Pennsylvania State University, University Park, PA 16802 (United States); Fleischhack, H. [DESY, Platanenallee 6, D-15738 Zeuthen (Germany); Fortson, L. [School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455 (United States); Furniss, A., E-mail: nahee@uchicago.edu [Department of Physics, California State University—East Bay, Hayward, CA 94542 (United States); and others

2017-02-10

High-energy gamma-ray emission from supernova remnants (SNRs) has provided a unique perspective for studies of Galactic cosmic-ray acceleration. Tycho’s SNR is a particularly good target because it is a young, type Ia SNR that has been well-studied over a wide range of energies and located in a relatively clean environment. Since the detection of gamma-ray emission from Tycho’s SNR by VERITAS and Fermi -LAT, there have been several theoretical models proposed to explain its broadband emission and high-energy morphology. We report on an update to the gamma-ray measurements of Tycho’s SNR with 147 hr of VERITAS and 84 months of Fermi -LAT observations, which represent about a factor of two increase in exposure over previously published data. About half of the VERITAS data benefited from a camera upgrade, which has made it possible to extend the TeV measurements toward lower energies. The TeV spectral index measured by VERITAS is consistent with previous results, but the expanded energy range softens a straight power-law fit. At energies higher than 400 GeV, the power-law index is 2.92 ± 0.42{sub stat} ± 0.20{sub sys}. It is also softer than the spectral index in the GeV energy range, 2.14 ± 0.09{sub stat} ± 0.02{sub sys}, measured in this study using Fermi -LAT data. The centroid position of the gamma-ray emission is coincident with the center of the remnant, as well as with the centroid measurement of Fermi -LAT above 1 GeV. The results are consistent with an SNR shell origin of the emission, as many models assume. The updated spectrum points to a lower maximum particle energy than has been suggested previously.

FERMI/LAT OBSERVATIONS OF LS 5039

International Nuclear Information System (INIS)

Abdo, A. A.; Ackermann, M.; Ajello, M.; Bechtol, K.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Brez, A.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Baughman, B. M.; Bonamente, E.; Brigida, M.

2009-01-01

The first results from observations of the high-mass X-ray binary LS 5039 using the Fermi Gamma-ray Space Telescope data between 2008 August and 2009 June are presented. Our results indicate variability that is consistent with the binary period, with the emission being modulated with a period of 3.903 ± 0.005 days; the first detection of this modulation at GeV energies. The light curve is characterized by a broad peak around superior conjunction in agreement with inverse Compton scattering models. The spectrum is represented by a power law with an exponential cutoff, yielding an overall flux (100 MeV-300 GeV) of 4.9 ± 0.5(stat) ± 1.8(syst) x10 -7 photon cm -2 s -1 , with a cutoff at 2.1 ± 0.3(stat) ± 1.1(syst) GeV and photon index Γ = 1.9 ± 0.1(stat) ± 0.3(syst). The spectrum is observed to vary with orbital phase, specifically between inferior and superior conjunction. We suggest that the presence of a cutoff in the spectrum may be indicative of magnetospheric emission similar to the emission seen in many pulsars by Fermi.

Effect of Weakly Nonthermal Ion Velocity Distribution on Jeans Instability in a Complex Plasma in Presence of Secondary Electrons

International Nuclear Information System (INIS)

Sarkar, S.; Maity, S.

2013-01-01

In this paper we have investigated the effect of weak nonthermality of ion velocity distribution on Jean’s instability in a complex plasma in presence of secondary electrons and negatively charged dust grains. The primary and secondary electron temperatures are assumed equal. Thus plasma under consideration consists of three components: Boltzman distributed electrons, non-thermal ions and negatively charged inertial dust grains. From the linear dispersion relation we have calculated the real frequency and growth rate of the Jean’s mode. Numerically we have found that secondary electron emission destabilizes Jean’s mode when ion nonthermality is weak. (author)

Early X- and HE γ-ray emission from the symbiotic recurrent novae V745 Sco & RS Oph.

Science.gov (United States)

Delgado, L.; Hernanz, M.

2017-10-01

RS Oph was the first nova for which evidence of particle acceleration during its 2006 outburst was found. In recent years, several nova explosions - eight classical and two symbiotic recurrent novae - have been detected by Fermi/LAT at E>100 MeV. In most cases, this emission has been observed early after the explosion, around the optical maximum, and for a short period of time. The high-energy γ-ray emission is a consequence of π^{0} decay and/or Inverse Compton, which are related to particle (p and e^{-}) acceleration in the strong shock between the nova ejecta and the circumstellar matter. Our aim is to understand the acceleration process through the analysis of contemporaneous X-ray emission, and in particular, through the evolution of the shock wave. A deep analysis of early X-ray observations of the symbiotic recurrent novae V745 Sco (2014) by Swift/XRT, Chandra/HETG and NuStar, and RS Oph (2006) by XMM-Newton/EPIC and RGS, Swift/XRT and BAT and RXTE/PCA is presented taking into account the contemporaneous information from the IR and radio observations. This provides for the first time a global view of the early evolution of a nova remnant and its relationship with particle acceleration.

3 mm GMVA Observations of Total and Polarized Emission from Blazar and Radio Galaxy Core Regions

Directory of Open Access Journals (Sweden)

Carolina Casadio

2017-10-01

Full Text Available We present total and linearly polarized 3 mm Global mm-VLBI Array (GMVA; mm-VLBI: Very Long Baseline Interferometry observations at millimetre wavelengths images of a sample of blazars and radio galaxies from the VLBA-BU-BLAZAR 7 mm monitoring program designed to probe the innermost regions of active galactic nuclei (AGN jets and locate the sites of gamma-ray emission observed by the Fermi-LAT. The lower opacity at 3 mm and improved angular resolution—on the order of 50 microarcseconds—allow us to distinguish features in the jet not visible in the 7 mm VLBA data. We also compare two different methods used for the calibration of instrumental polarisation and we analyze the resulting images for some of the sources in the sample.

Reduction of weak interaction rates in neutron stars by nucleon spin fluctuations: Degenerate case

International Nuclear Information System (INIS)

Raffelt, G.; Strobel, T.

1997-01-01

Nucleon spin fluctuations in a dense medium reduce the open-quotes naiveclose quotes values of weak interaction rates (neutrino opacities, neutrino emissivities). We extend previous studies of this effect to the degenerate case which is appropriate for neutron stars a few ten seconds after formation. If neutron-neutron interactions by a one-pion exchange potential are the dominant cause of neutron spin fluctuations, a perturbative calculation of weak interaction rates is justified for T approx-lt 3m/(4πα π 2 )∼1MeV, where m is the neutron mass and α π ∼15 the pion fine-structure constant. At higher temperatures, the application of Landau close-quote s theory of Fermi liquids is no longer justified; i.e., the neutrons cannot be viewed as simple quasiparticles in any obvious sense. copyright 1997 The American Physical Society

Interference of Photons from a Weak Laser and a Quantum Dot

Science.gov (United States)

Ritchie, David; Bennett, Anthony; Patel, Raj; Nicoll, Christine; Shields, Andrew

2010-03-01

We demonstrate two-photon interference from two unsynchronized sources operating via different physical processes [1]. One source is spontaneous emission from the X^- state of an electrically-driven InAs/GaAs single quantum dot with μeV linewidth, the other stimulated emission from a laser with a neV linewidth. We mix the emission from these sources on a balanced non-polarising beam splitter and measure correlations in the photons that exit using Si-avalanche photodiodes and a time-correlated counting card. By periodically switching the polarisation state of the weak laser we simultaneously measure the correlation for parallel and orthogonally polarised sources, corresponding to maximum and minimum degrees of interference. When the two sources have the same intensity, a reduction in the correlation function at time zero for the case of parallel photon sources clearly indicates this interference effect. To quantify the degree of interference, we develop a theory that predicts the correlation function. Data and experiment are then compared for a range of intensity ratios. Based on this analysis we infer a wave-function overlap of 91%, which is remarkable given the fundamental differences between the two sources. [1] Bennett A. J et al Nature Physics, 5, 715--717 (2009).

Weak Solution and Weakly Uniformly Bounded Solution of Impulsive Heat Equations Containing “Maximum” Temperature

Directory of Open Access Journals (Sweden)

Oyelami, Benjamin Oyediran

2013-09-01

Full Text Available In this paper, criteria for the existence of weak solutions and uniformly weak bounded solution of impulsive heat equation containing maximum temperature are investigated and results obtained. An example is given for heat flow system with impulsive temperature using maximum temperature simulator and criteria for the uniformly weak bounded of solutions of the system are obtained.

Discovery of Nine Gamma-Ray Pulsars in Fermi-Lat Data Using a New Blind Search Method

Science.gov (United States)

Celik-Tinmaz, Ozlem; Ferrara, E. C.; Pletsch, H. J.; Allen, B.; Aulbert, C.; Fehrmann, H.; Kramer, M.; Barr, E. D.; Champion, D. J.; Eatough, R. P.;

A weak balance: the contribution of muscle weakness to postural instability and falls.

NARCIS (Netherlands)

Horlings, G.C.; Engelen, B.G.M. van; Allum, J.H.J.; Bloem, B.R.

2008-01-01

Muscle strength is a potentially important factor contributing to postural control. In this article, we consider the influence of muscle weakness on postural instability and falling. We searched the literature for research evaluating muscle weakness as a risk factor for falls in community-dwelling

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

NARCIS (Netherlands)

Rosilio, C.; Nebout, M.; Imbert, V.; Griessinger, E.; Neffati, Z.; Benadiba, J.; Hagenbeek, T.; Spits, H.; Reverso, J.; Ambrosetti, D.; Michiels, J.-F.; Bailly-Maitre, B.; Endou, H.; Wempe, M. F.; Peyron, J.-F.

2015-01-01

The altered metabolism of cancer cells is a treasure trove to discover new antitumoral strategies. The gene (SLC7A5) encoding system L amino-acid transporter 1 (LAT1) is overexpressed in murine lymphoma cells generated via T-cell deletion of the pten tumor suppressor, and also in human T-cell acute

Select problems of the electrodynamics of superconducting weak-coupled systems

International Nuclear Information System (INIS)

Belenov, E.M.; Vedeneev, S.I.; Uskov, A.V.

1988-01-01

The interaction of currents in superconducting Josephson elements irradiated by electromagnetic fields in a cavity and a waveguide is considered theoretically. The possibility of using weak-coupled systems to implement stimulated emission oscillators tunable over a broad range from 10 10 to 10 13 Hz is investigated. The properties of a superconducting point contact for use as a nonlinear element in a reference frequency circuit from the microwave to the optical ranges are investigated theoretically. The possibility of frequency synthesis by means of a single nonlinear element from the microwave range to the optical range is demonstrated together with the capacity for precision laser frequency measurements. The noise aspects of using superconducting elements for laser frequency measurements are investigated

Charged weak currents

International Nuclear Information System (INIS)

Turlay, R.

1979-01-01

In this review of charged weak currents I shall concentrate on inclusive high energy neutrino physics. There are surely still things to learn from the low energy weak interaction but I will not discuss it here. Furthermore B. Tallini will discuss the hadronic final state of neutrino interactions. Since the Tokyo conference a few experimental results have appeared on charged current interaction, I will present them and will also comment on important topics which have been published during the last past year. (orig.)

Weak-interacting holographic QCD

International Nuclear Information System (INIS)

Gazit, D.; Yee, H.-U.

2008-06-01

We propose a simple prescription for including low-energy weak-interactions into the frame- work of holographic QCD, based on the standard AdS/CFT dictionary of double-trace deformations. As our proposal enables us to calculate various electro-weak observables involving strongly coupled QCD, it opens a new perspective on phenomenological applications of holographic QCD. We illustrate efficiency and usefulness of our method by performing a few exemplar calculations; neutron beta decay, charged pion weak decay, and meson-nucleon parity non-conserving (PNC) couplings. The idea is general enough to be implemented in both Sakai-Sugimoto as well as Hard/Soft Wall models. (author)

Second class weak currents

International Nuclear Information System (INIS)

Delorme, J.

1978-01-01

The definition and general properties of weak second class currents are recalled and various detection possibilities briefly reviewed. It is shown that the existing data on nuclear beta decay can be consistently analysed in terms of a phenomenological model. Their implication on the fundamental structure of weak interactions is discussed [fr

BL Lacertae Objects Beyond Redshift 1.3 - UV-to-NIR Photometry and Photometric Redshift for Fermi/LAT Blazars

Science.gov (United States)

Rau, A.; Schady, P.; Greiner, J.; Salvato, M.; Ajello, M.; Bottacini, E.; Gehrels, N.; Afonso, P. M. J.; Elliott, J.; Filgas, R.;

The Fermi-LAT gamma-ray excess at the Galactic Center in the singlet-doublet fermion dark matter model

Energy Technology Data Exchange (ETDEWEB)

Horiuchi, Shunsaku; Macias, Oscar [Center for Neutrino Physics, Department of Physics, Virginia Tech, Blacksburg, VA 24061 (United States); Restrepo, Diego; Rivera, Andrés; Zapata, Oscar [Instituto de Física, Universidad de Antioquia, Calle 70 No. 52-21, Medellín (Colombia); Silverwood, Hamish, E-mail: horiuchi@vt.edu, E-mail: oscar.macias@vt.edu, E-mail: restrepo@udea.edu.co, E-mail: afelipe.rivera@udea.edu.co, E-mail: oalberto.zapata@udea.edu.co, E-mail: h.g.m.silverwood@uva.nl [GRAPPA, University of Amsterdam, Science Park 904, 1098 XH Amsterdam (Netherlands)

2016-03-01

The singlet-doublet fermion dark matter model (SDFDM) provides a good DM candidate as well as the possibility of generating neutrino masses radiatively. The search and identification of DM requires the combined effort of both indirect and direct DM detection experiments in addition to the LHC. Remarkably, an excess of GeV gamma rays from the Galactic Center (GCE) has been measured with the Fermi Large Area Telescope (LAT) which appears to be robust with respect to changes in the diffuse galactic background modeling. Although several astrophysical explanations have been proposed, DM remains a simple and well motivated alternative. In this work, we examine the sensitivities of dark matter searches in the SDFDM scenario using Fermi-LAT, CTA, IceCube/DeepCore, LUX, PICO and LHC with an emphasis on exploring the regions of the parameter space that can account for the GCE. We find that DM particles present in this model with masses close to ∼ 99 GeV and ∼ (173–190) GeV annihilating predominantly into the W{sup +}W{sup −} channel and t t-bar channel respectively, provide an acceptable fit to the GCE while being consistent with different current experimental bounds. We also find that much of the obtained parameter space can be ruled out by future direct search experiments like LZ and XENON-1T, in case of null results by these detectors. Interestingly, we show that the most recent data by LUX is starting to probe the best fit region in the SDFDM model.

Standard and Null Weak Values

OpenAIRE

Zilberberg, Oded; Romito, Alessandro; Gefen, Yuval

2013-01-01

Weak value (WV) is a quantum mechanical measurement protocol, proposed by Aharonov, Albert, and Vaidman. It consists of a weak measurement, which is weighed in, conditional on the outcome of a later, strong measurement. Here we define another two-step measurement protocol, null weak value (NVW), and point out its advantages as compared to WV. We present two alternative derivations of NWVs and compare them to the corresponding derivations of WVs.

The GAMMA Ray Sky as Seen by Fermi: Opening a New Window on the High Energy Space Environment

Science.gov (United States)

2009-01-01

important early discoveries of Fermi have been from objects in our galaxy. The LAT has discovered 12 new pulsars that seem to be visible only in gamma...have now been discov- ered by LAT. Finally, the discovery of pulsed gamma rays from several radio pulsars with millisecond spin periods, previously... pulsars , stars whose repeating emissions can be used as ultra-precise chronometers. Measurement of gamma radiation provides unique insight

A forward looking, actor based, indicator for climate gas emissions

Energy Technology Data Exchange (ETDEWEB)

Ericson, Torgeir; Randers, Joergen

2011-04-15

The most commonly used Norwegian indicator for climate change displays historical emissions and compare with Norway's Kyoto target. This indicator says little about future emissions, about the ongoing Norwegian effort to reduce climate gas emissions, or about its effect on sustainability. In this paper we propose an indicator that improves on these weaknesses. We present a forward looking climate indicator that in addition to historic data includes business as usual scenarios, different proposals for future domestic emissions, and national or international commitments and agreements. This indicator presents - in one graph - a broad diversity of views on how the climate challenge should be handled from now and into the future. This indicator-graph may contribute to a more transparent discussion of available policy options. (Author)

DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins

DEFF Research Database (Denmark)

Nguyen, Thanh Hung; Kugler, Jan-Michael; Cohen, Stephen Michael

2017-01-01

/TAZ, is regulated by ubiquitin mediated protein turnover and several ubiquitin ligase complexes have been implicated in human cancer. However, little is known about the deubiquitylating enzymes that counteract these ubiquitin ligases in regulation of the Hippo pathway. Here we identify the DUB3 family...... deubiquitylating enzymes as regulators of Hippo pathway activity. We provide evidence that DUB3 proteins regulate YAP/TAZ activity by controlling the stability of the E3 ligase ITCH, the LATS kinases and the AMOT family proteins. As a novel Hippo pathway regulator, DUB3 has the potential to act a tumor suppressor...

Quantum degeneracy corrections to plasma line emission and to Saha equation

International Nuclear Information System (INIS)

Molinari, V.G.; Mostacci, D.; Rocchi, F.; Sumini, M.

2003-01-01

The effect of quantum degeneracy on the electron collisional excitation is investigated, and its effects on line emission evaluated for applications to spectroscopy of dense, cold plasmas. A correction to Saha equation for weakly-degenerate plasmas is also presented

Weak interactions

International Nuclear Information System (INIS)

Chanda, R.

1981-01-01

The theoretical and experimental evidences to form a basis for Lagrangian Quantum field theory for Weak Interactions are discussed. In this context, gauge invariance aspects of such interactions are showed. (L.C.) [pt

OBSERVATIONS OF THE YOUNG SUPERNOVA REMNANT RX J1713.7-3946 WITH THE FERMI LARGE AREA TELESCOPE

International Nuclear Information System (INIS)

Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Ballet, J.; Barbiellini, G.; Baring, M. G.; Bastieri, D.; Bonamente, E.; Bouvier, A.; Brandt, T. J.; Brigida, M.; Bruel, P.

2011-01-01

We present observations of the young supernova remnant (SNR) RX J1713.7-3946 with the Fermi Large Area Telescope (LAT). We clearly detect a source positionally coincident with the SNR. The source is extended with a best-fit extension of 0. 0 55 ± 0. 0 04 matching the size of the non-thermal X-ray and TeV gamma-ray emission from the remnant. The positional coincidence and the matching extended emission allow us to identify the LAT source with SNR RX J1713.7-3946. The spectrum of the source can be described by a very hard power law with a photon index of Γ = 1.5 ± 0.1 that coincides in normalization with the steeper H.E.S.S.-detected gamma-ray spectrum at higher energies. The broadband gamma-ray emission is consistent with a leptonic origin as the dominant mechanism for the gamma-ray emission.

Strategies for enhanced deammonification performance and reduced nitrous oxide emissions.

Science.gov (United States)

Leix, Carmen; Drewes, Jörg E; Ye, Liu; Koch, Konrad

2017-07-01

Deammonification's performance and associated nitrous oxide emissions (N 2 O) depend on operational conditions. While studies have investigated factors for high performances and low emissions separately, this study investigated optimizing deammonification performance while simultaneously reducing N 2 O emissions. Using a design of experiment (DoE) method, two models were developed for the prediction of the nitrogen removal rate and N 2 O emissions during single-stage deammonification considering three operational factors (i.e., pH value, feeding and aeration strategy). The emission factor varied between 0.7±0.5% and 4.1±1.2% at different DoE-conditions. The nitrogen removal rate was predicted to be maximized at settings of pH 7.46, intermittent feeding and aeration. Conversely, emissions were predicted to be minimized at the design edges at pH 7.80, single feeding, and continuous aeration. Results suggested a weak positive correlation between the nitrogen removal rate and N 2 O emissions, thus, a single optimizing operational set-point for maximized performance and minimized emissions did not exist. Copyright © 2017 Elsevier Ltd. All rights reserved.

Combination of e+/e- ratio from AMS-02 and gamma ray line from Fermi-LAT with implication for Dark Matter

OpenAIRE

Li, Shiyuan; Luo, Yonggang

2013-01-01

The precise AMS-02 data provide definite information for the e+/e- ratio in 100 - 350 GeV region. Assuming that the recent gamma ray line observed by Fermi-LAT experiment is product of dark matter in space and taken as input. We make a global fit for the AMS-02 e+/e- spectrum with both dark matter and pulsar contribution. For this spectrum over 130 GeV, pulsar is the dominant contribution. We also investigate the constrains on hadron production from dark matter annihilation.

The Intrinsically X-Ray-weak Quasar PHL 1811. II. Optical and UV Spectra and Analysis

Science.gov (United States)

Leighly, Karen M.; Halpern, Jules P.; Jenkins, Edward B.; Casebeer, Darrin

2007-11-01

This is the second of two papers reporting observations and analysis of the unusually bright (mb=14.4), luminous (MB=-25.5), nearby (z=0.192) narrow-line quasar PHL 1811. The first paper reported that PHL 1811 is intrinsically X-ray-weak and presented a spectral energy distribution (SED). Here we present HST STIS optical and UV spectra, and ground-based optical spectra. The optical and UV line emission is very unusual. There is no evidence for forbidden or semiforbidden lines. The near-UV spectrum is dominated by very strong Fe II and Fe III, and unusual low-ionization lines such as Na I D and Ca II H and K are observed. High-ionization lines are very weak; C IV has an equivalent width of 6.6 Å, a factor of ~5 smaller than measured from quasar composite spectra. An unusual feature near 1200 Å can be deblended in terms of Lyα, N V, Si II, and C III* using the blueshifted C IV profile as a template. Photoionization modeling shows that the unusual line emission can be explained qualitatively by the unusually soft SED. Principally, a low gas temperature results in inefficient emission of collisionally excited lines, including the semiforbidden lines generally used as density diagnostics. The emission resembles that of high-density gas; in both cases this is a consequence of inefficient cooling. PHL 1811 is very unusual, but we note that quasar surveys may be biased against finding similar objects. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. These observations are associated with proposal 9181. Based on observations obtained at Kitt Peak National Observatory, a division of the National Optical Astronomy Observatories, which is operated by the Association of Universities for Research in Astronomy, Inc., under cooperative agreement with the National Science Foundation.

ENERGETIC FERMI/LAT GRB 100414A: ENERGETIC AND CORRELATIONS

Energy Technology Data Exchange (ETDEWEB)

Urata, Yuji; Tsai, Patrick P. [Institute of Astronomy, National Central University, Chung-Li 32054, Taiwan (China); Huang, Kuiyun [Academia Sinica Institute of Astronomy and Astrophysics, Taipei 106, Taiwan (China); Yamaoka, Kazutaka [Department of Physics and Mathematics, Aoyama Gakuin University, 5-10-1, Fuchinobe, Sayamihara 229-8558 (Japan); Tashiro, Makoto S., E-mail: urata@astro.ncu.edu.tw [Department of Physics, Saitama University, Shimo-Okubo, Saitama 338-8570 (Japan)

2012-03-20

This study presents multi-wavelength observational results for energetic GRB 100414A with GeV photons. The prompt spectral fitting using Suzaku/WAM data yielded spectral peak energies of E{sup src}{sub peak} of 1458.7{sup +132.6}{sub -106.6} keV and E{sub iso} of 34.5{sup +2.0}{sub -1.8} Multiplication-Sign 10{sup 52} erg with z = 1.368. The optical afterglow light curves between 3 and 7 days were effectively fitted according to a simple power law with a temporal index of {alpha} = -2.6 {+-} 0.1. The joint light curve with earlier Swift/UVOT observations yields a temporal break at 2.3 {+-} 0.2 days. This was the first Fermi/LAT detected event that demonstrated the clear temporal break in the optical afterglow. The jet opening angle derived from this temporal break was 5.{sup 0}8, consistent with those of other well-observed long gamma-ray bursts (GRBs). The multi-wavelength analyses in this study showed that GRB 100414A follows E{sup src}{sub peak}-E{sub iso} and E{sup src}{sub peak}-E{sub {gamma}} correlations. The late afterglow revealed a flatter evolution with significant excesses at 27.2 days. The most straightforward explanation for the excess is that GRB 100414A was accompanied by a contemporaneous supernova. The model light curve based on other GRB-SN events is marginally consistent with that of the observed light curve.

ENERGETIC FERMI/LAT GRB 100414A: ENERGETIC AND CORRELATIONS

International Nuclear Information System (INIS)

Urata, Yuji; Tsai, Patrick P.; Huang, Kuiyun; Yamaoka, Kazutaka; Tashiro, Makoto S.

2012-01-01

This study presents multi-wavelength observational results for energetic GRB 100414A with GeV photons. The prompt spectral fitting using Suzaku/WAM data yielded spectral peak energies of E src peak of 1458.7 +132.6 –106.6 keV and E iso of 34.5 +2.0 –1.8 × 10 52 erg with z = 1.368. The optical afterglow light curves between 3 and 7 days were effectively fitted according to a simple power law with a temporal index of α = –2.6 ± 0.1. The joint light curve with earlier Swift/UVOT observations yields a temporal break at 2.3 ± 0.2 days. This was the first Fermi/LAT detected event that demonstrated the clear temporal break in the optical afterglow. The jet opening angle derived from this temporal break was 5. 0 8, consistent with those of other well-observed long gamma-ray bursts (GRBs). The multi-wavelength analyses in this study showed that GRB 100414A follows E src peak -E iso and E src peak -E γ correlations. The late afterglow revealed a flatter evolution with significant excesses at 27.2 days. The most straightforward explanation for the excess is that GRB 100414A was accompanied by a contemporaneous supernova. The model light curve based on other GRB-SN events is marginally consistent with that of the observed light curve.

Potencial evocado auditivo de longa latência para estímulo de fala apresentado com diferentes transdutores em crianças ouvintes Late auditory evoked potentials to speech stimuli presented with different transducers in hearing children

Directory of Open Access Journals (Sweden)

Raquel Sampaio Agostinho-Pesse

2013-01-01

Full Text Available OBJETIVO: analisar, de forma comparativa, a influência do transdutor no registro dos componentes P1, N1 e P2 eliciados por estímulo de fala, quanto à latência e à amplitude, em crianças ouvintes. MÉTODO: 30 crianças ouvintes de quatro a 12 anos de idade, de ambos os sexos. Os potenciais evocados auditivos de longa latência foram pesquisados por meio dos transdutores, fone de inserção e caixa acústica, eliciados por estímulo de fala /da/, sendo o intervalo interestímulos de 526ms, a intensidade de 70dBNA e a taxa de apresentação de 1,9 estímulos por segundo. Foram analisados os componentes P1, N1 e P2 quando presentes, quanto à latência e à amplitude. RESULTADOS: constatou-se um nível de concordância forte entre a pesquisadora e o juiz. Não houve diferença estatisticamente significante ao comparar os valores de latência e amplitude dos componentes P1, N1 e P2, ao considerar sexo e orelha, assim como para a latência dos componentes quando analisado os tipos de transdutores. Entretanto, houve diferença estatisticamente significante para a amplitude dos componentes P1 e N1, com maior amplitude para o transdutor caixa acústica. CONCLUSÃO: os valores de latência dos componentes P1, N1 e P2 e amplitude de P2 obtidos com fone de inserção podem ser utilizados como referência de normalidade independente do transdutor utilizado para a pesquisa dos potenciais evocados auditivos de longa latência.PURPOSE: to analyze, in a comparative manner, the influence of the transducer on the recordings of P1, N1 and P2components elicited through speech stimulus, as to the latency and amplitude in hearing children. METHOD: the sample was comprised of 30 hearing children aged 4-12 yrs, both genders. The long latency auditory evoked potentials were researched by means of transducers, insertion phone and speakers, elicited through speech stimulus /da/ presented with interstimuli interval of 526ms, the intensity of 70dBNA and presentation

Sustained >100 MeV Gamma-Ray Emission: A Monitor for >300 MeV SEP Protons at the Sun

Science.gov (United States)

Share, G. H.; Murphy, R. J.

2017-12-01

Solar γ radiation is the product of proton and ion interactions in the solar atmosphere. The spectrum and temporal characteristics of the emission provides fundamental information on the ions at the Sun. Until the launch of the Fermi satellite, with its Large Area Telescope (LAT) sensitive to radiation above 100 MeV, most of the γ-ray observations were made in the nuclear energy range with radiation arising from interaction of one to tens of MeV ions produced in solar flares. Since 2008 the LAT has detected 30 high-energy γ-ray events with temporal and spectral characteristics that are distinct from the associated solar flare. We call this radiation Sustained Gamma-Ray Emission (SGRE) and briefly summarize its characteristics reported in a recent paper. The γ-ray spectra are consistent with pion decay radiation produced by protons above 300 MeV. The onset of the radiation most often occurs after the impulsive flare and the emission can last several hours. We find that the number of protons responsible for the SGRE is typically more than 10 times the number of flare-accelerated protons. These characteristics require that there be an additional source of energy to accelerate the protons to hundreds of MeV to produce the SGRE. As 28 of the 30 SGRE events are accompanied by fast CMEs, it is likely that these protons are accelerated by the same shock that produces gradual SEPs. We find that the number of protons >500 MeV in the accompanying SEPs is typically about 50-100 times the number of protons that return to the Sun to produce the SGRE. There also appear to be correlations between the numbers of SEP and SGRE protons and durations of >100 MeV SEP proton and SGRE events. We find that for all SGRE events where there were flare observations, the accompanying impulsive X-radiation reached energies >100 keV. In a limited study of 18 solar events with CME speeds >800 km/s we also find that the median SEP proton flux is 25 times higher when flare hard X-rays exceed 100

Feasibility of isotachochromatography as a method for the preparative separation of weak acids and weak bases. I. Theoretical considerations

NARCIS (Netherlands)

Kooistra, C.; Sluyterman, L.A.A.E.

1988-01-01

The fundamental equation of isotachochromatography, i.e., isotachophoresis translated into ion-exchange chromatography, has been derived for weak acids and weak bases. Weak acids are separated on strong cation exchangers and weak bases on strong anion exchangers. According to theory, the elution

Energy intensity, CO{sub 2} emissions and the environmental Kuznets curve. The Spanish case

Energy Technology Data Exchange (ETDEWEB)

Roca, J. [Universitat de Barcelona (Spain). Dpt. Teoria Economica; Alcantara, V. [Universitat Autonoma de Barcelona (Spain). Dpt. Economia Aplicada

2001-06-01

This article analyses the role of energy intensity and the relationship between CO{sub 2} emissions and primary energy in order to explain the evolution of CO{sub 2} emissions by unit of real GDP. It also distinguishes two different meanings of CO{sub 2} emissions Kuznets curve hypothesis: the weak and the strong sense. It considers the case of Spain in the period 1972-1997 as an example in which there is not any evidence supporting this hypothesis in either sense. (author)

Entropy, limits to growth, and the prospects for weak sustainability

International Nuclear Information System (INIS)

Krysiak, Frank C.

2006-01-01

In this paper, we analyze the consequences of mass and energy conservation and the second law of thermodynamics for economic activity. In contrast to former studies, we deduce our results formally from a general model of production and consumption. We show that in a static setting for economies containing irreversible processes, a non-zero resource input as well as non-zero emissions are necessary to sustain a positive level of consumption. We generalize this result to a dynamic setting and apply it to the growth discussion and the sustainability discourse. Thereby we show that limits to growth of production and consumption are likely to exist and that the concept of weak sustainability is either morally unattractive or physically infeasible. (author)

Assessment of the strengths and weaknesses of the new Real Driving Emissions (RDE) test procedure

NARCIS (Netherlands)

Cuelenaere, R.F.A.; Ligterink, N.E.

2016-01-01

Door Dieselgate is er hernieuwde aandacht voor de luchtverontreinigende uitlaatgassen van auto’s, in het bijzonder voor de hoge NOx praktijkemissies van moderne Euro-5 en Euro-6 personenauto’s en bestelwagens. De ontwikkeling van nieuwe Europese Real Driving Emissions (RDE) wetgeving wordt gezien

Riemann Geometric Color-Weak Compensationfor Individual Observers

OpenAIRE

Kojima, Takanori; Mochizuki, Rika; Lenz, Reiner; Chao, Jinhui

2014-01-01

We extend a method for color weak compensation based on the criterion of preservation of subjective color differences between color normal and color weak observers presented in [2]. We introduce a new algorithm for color weak compensation using local affine maps between color spaces of color normal and color weak observers. We show howto estimate the local affine map and how to determine correspondences between the origins of local coordinates in color spaces of color normal and color weak ob...

A NOVEL APPROACH IN THE WEAKLY INTERACTING MASSIVE PARTICLE QUEST: CROSS-CORRELATION OF GAMMA-RAY ANISOTROPIES AND COSMIC SHEAR

International Nuclear Information System (INIS)

Camera, Stefano; Fornasa, Mattia; Fornengo, Nicolao; Regis, Marco

2013-01-01

Both cosmic shear and cosmological gamma-ray emission stem from the presence of dark matter (DM) in the universe: DM structures are responsible for the bending of light in the weak-lensing regime and those same objects can emit gamma rays, either because they host astrophysical sources (active galactic nuclei or star-forming galaxies) or directly by DM annihilations (or decays, depending on the properties of the DM particle). Such gamma rays should therefore exhibit strong correlation with the cosmic shear signal. In this Letter, we compute the cross-correlation angular power spectrum of cosmic shear and gamma rays produced by the annihilation/decay of weakly interacting massive particle DM, as well as by astrophysical sources. We show that this observable provides novel information on the composition of the extragalactic gamma-ray background (EGB), since the amplitude and shape of the cross-correlation signal strongly depend on which class of sources is responsible for the gamma-ray emission. If the DM contribution to the EGB is significant (at least in a definite energy range), although compatible with current observational bounds, its strong correlation with the cosmic shear makes such signal potentially detectable by combining Fermi Large Area Telescope data with forthcoming galaxy surveys, like the Dark Energy Survey and Euclid. At the same time, the same signal would demonstrate that the weak-lensing observables are indeed due to particle DM matter and not to possible modifications of general relativity.

A Novel Approach in the Weakly Interacting Massive Particle Quest: Cross-correlation of Gamma-Ray Anisotropies and Cosmic Shear

Science.gov (United States)

Camera, Stefano; Fornasa, Mattia; Fornengo, Nicolao; Regis, Marco

2013-07-01

Both cosmic shear and cosmological gamma-ray emission stem from the presence of dark matter (DM) in the universe: DM structures are responsible for the bending of light in the weak-lensing regime and those same objects can emit gamma rays, either because they host astrophysical sources (active galactic nuclei or star-forming galaxies) or directly by DM annihilations (or decays, depending on the properties of the DM particle). Such gamma rays should therefore exhibit strong correlation with the cosmic shear signal. In this Letter, we compute the cross-correlation angular power spectrum of cosmic shear and gamma rays produced by the annihilation/decay of weakly interacting massive particle DM, as well as by astrophysical sources. We show that this observable provides novel information on the composition of the extragalactic gamma-ray background (EGB), since the amplitude and shape of the cross-correlation signal strongly depend on which class of sources is responsible for the gamma-ray emission. If the DM contribution to the EGB is significant (at least in a definite energy range), although compatible with current observational bounds, its strong correlation with the cosmic shear makes such signal potentially detectable by combining Fermi Large Area Telescope data with forthcoming galaxy surveys, like the Dark Energy Survey and Euclid. At the same time, the same signal would demonstrate that the weak-lensing observables are indeed due to particle DM matter and not to possible modifications of general relativity.

A NOVEL APPROACH IN THE WEAKLY INTERACTING MASSIVE PARTICLE QUEST: CROSS-CORRELATION OF GAMMA-RAY ANISOTROPIES AND COSMIC SHEAR

Energy Technology Data Exchange (ETDEWEB)

Camera, Stefano [CENTRA, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Lisboa (Portugal); Fornasa, Mattia [School of Physics and Astronomy, University of Nottingham, Nottingham (United Kingdom); Fornengo, Nicolao; Regis, Marco [Dipartimento di Fisica, Universita di Torino and INFN, Torino (Italy)

2013-07-01

Both cosmic shear and cosmological gamma-ray emission stem from the presence of dark matter (DM) in the universe: DM structures are responsible for the bending of light in the weak-lensing regime and those same objects can emit gamma rays, either because they host astrophysical sources (active galactic nuclei or star-forming galaxies) or directly by DM annihilations (or decays, depending on the properties of the DM particle). Such gamma rays should therefore exhibit strong correlation with the cosmic shear signal. In this Letter, we compute the cross-correlation angular power spectrum of cosmic shear and gamma rays produced by the annihilation/decay of weakly interacting massive particle DM, as well as by astrophysical sources. We show that this observable provides novel information on the composition of the extragalactic gamma-ray background (EGB), since the amplitude and shape of the cross-correlation signal strongly depend on which class of sources is responsible for the gamma-ray emission. If the DM contribution to the EGB is significant (at least in a definite energy range), although compatible with current observational bounds, its strong correlation with the cosmic shear makes such signal potentially detectable by combining Fermi Large Area Telescope data with forthcoming galaxy surveys, like the Dark Energy Survey and Euclid. At the same time, the same signal would demonstrate that the weak-lensing observables are indeed due to particle DM matter and not to possible modifications of general relativity.

Radio core dominance of Fermi blazars

Science.gov (United States)

Pei, Zhi-Yuan; Fan, Jun-Hui; Liu, Yi; Yuan, Yi-Hai; Cai, Wei; Xiao, Hu-Bing; Lin, Chao; Yang, Jiang-He

2016-07-01

During the first 4 years of mission, Fermi/LAT detected 1444 blazars (3FGL) (Ackermann et al. in Astrophys. J. 810:14, 2015). Fermi/LAT observations of blazars indicate that Fermi blazars are luminous and strongly variable with variability time scales, for some cases, as short as hours. Those observations suggest a strong beaming effect in Fermi/LAT blazars. In the present work, we will investigate the beaming effect in Fermi/LAT blazars using a core-dominance parameter, R = S_{core}/ S_{ext.}, where S_{core} is the core emission, while S_{ext.} is the extended emission. We compiled 1335 blazars with available core-dominance parameter, out of which 169 blazars have γ-ray emission (from 3FGL). We compared the core-dominance parameters, log R, between the 169 Fermi-detected blazars (FDBs) and the rest non-Fermi-detected blazars (non-FDBs), and we found that the averaged values are R+(2.25±0.10), suggesting that a source with larger log R has larger V.I. value. Thirdly, we compared the mean values of radio spectral index for FDBs and non-FDBs, and we obtained < α_{radio}rangle =0.06±0.35 for FDBs and < α_{radio}rangle =0.57±0.46 for non-FDBs. If γ-rays are composed of two components like radio emission (core and extended components), then we can expect a correlation between log R and the γ-ray spectral index. When we used the radio core-dominance parameter, log R, to investigate the relationship, we found that the spectral index for the core component is α_{γ}|_{core} = 1.11 (a photon spectral index of α_{γ}^{ph}|_{core} = 2.11) and that for the extended component is α_{γ}|_{ext.} = 0.70 (a photon spectral index of α_{γ}^{ph}|_{ext.} = 1.70). Some discussions are also presented.

Coherent manipulation of spontaneous emission spectra in coupled semiconductor quantum well structures.

Science.gov (United States)

Chen, Aixi

2014-11-03

In triple coupled semiconductor quantum well structures (SQWs) interacting with a coherent driving filed, a coherent coupling field and a weak probe field, spontaneous emission spectra are investigated. Our studies show emission spectra can easily be manipulated through changing the intensity of the driving and coupling field, detuning of the driving field. Some interesting physical phenomena such as spectral-line enhancement/suppression, spectral-line narrowing and spontaneous emission quenching may be obtained in our system. The theoretical studies of spontaneous emission spectra in SQWS have potential application in high-precision spectroscopy. Our studies are based on the real physical system [Appl. Phys. Lett.86(20), 201112 (2005)], and this scheme might be realizable with presently available techniques.

Fermi LAT Detection of a GeV Flare from the Radio-Loud Narrow-Line Sy1 1H 0323+342

Science.gov (United States)

Carpenter, Bryce; Ojha, Roopesh

2013-08-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with 1H 0323+342 (RA=03h24m41.1613s, Dec=+34d10m45.856s, J2000; Beasley et al. 2002, ApJS, 141, 13) at z= 0.061 (Marcha et al. 1996, MNRAS, 281, 425). This is the second nearest radio-loud Narrow-Line Seyfert 1 galaxy, a small and important class of gamma-ray loud AGN (Abdo et al.

SEARCHING THE GAMMA-RAY SKY FOR COUNTERPARTS TO GRAVITATIONAL WAVE SOURCES: FERMI GAMMA-RAY BURST MONITO R AND LARGE AREA TELESCOPE OBSERVATIONS OF LVT151012 AND GW151226

Energy Technology Data Exchange (ETDEWEB)

Racusin, J. L.; Camp, J.; Singer, L. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Burns, E. [Physics Dept, University of Alabama in Huntsville, 320 Sparkman Dr., Huntsville, AL 35805 (United States); Goldstein, A.; Connaughton, V.; Littenberg, T.; Cleveland, W. [Universities Space Research Association, 320 Sparkman Dr. Huntsville, AL 35806 (United States); Wilson-Hodge, C. A.; Hui, C. M. [Astrophysics Office, ZP12, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Jenke, P.; Briggs, M. S.; Bhat, P. N. [CSPAR, University of Alabama in Huntsville, 320 Sparkman Dr., Huntsville, AL 35805 (United States); Blackburn, L. [LIGO, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Broida, J.; Christensen, N. [Physics and Astronomy, Carleton College, MN 55057 (United States); Shawhan, P. [Department of Physics, University of Maryland, College Park, MD 20742 (United States); Veitch, J. [University of Birmingham, Birmingham B15 2TT (United Kingdom); Fitzpatrick, G. [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Gibby, M. H. [Jacobs Technology, Inc., Huntsville, AL (United States); Collaboration: Fermi LAT Collaboration; and others

2017-01-20

We present the Fermi Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) observations of the LIGO binary black hole merger event GW151226 and candidate LVT151012. At the time of the LIGO triggers on LVT151012 and GW151226, GBM was observing 68% and 83% of the localization regions, and LAT was observing 47% and 32%, respectively. No candidate electromagnetic counterparts were detected by either the GBM or LAT. We present a detailed analysis of the GBM and LAT data over a range of timescales from seconds to years, using automated pipelines and new techniques for characterizing the flux upper bounds across large areas of the sky. Due to the partial GBM and LAT coverage of the large LIGO localization regions at the trigger times for both events, differences in source distances and masses, as well as the uncertain degree to which emission from these sources could be beamed, these non-detections cannot be used to constrain the variety of theoretical models recently applied to explain the candidate GBM counterpart to GW150914.

Characteristics of Gamma-Ray Loud Blazars in the VLBA Imaging and Polarimetry Survey

Science.gov (United States)

Linford, J. D.; Taylor, G. B.; Romani, R. W.; Healey, S. E.; Helmboldt, J. F.; Readhead, A. C.; Reeves, R.; Richards, J. L.; Cotter, G.

2010-01-01

The radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been observed as part of the VLBA Imaging and Polarimetry Survey. This large, flux-limited sample of active galactic nuclei (AGNs) provides insights into the mechanism that produces strong gamma-ray emission. At lower flux levels, radio flux density does not directly correlate with gamma-ray flux. We find that the LAT-detected BL Lac objects tend to be similar to the non-LAT BL Lac objects, but that the LAT-detected FSRQs are often significantly different from the non-LAT FSRQs. The differences between the gamma-ray loud and quiet FSRQS can be explained by Doppler boosting; these objects appear to require larger Doppler factors than those of the BL Lac objects. It is possible that the gamma-ray loud FSRQs are fundamentally different from the gamma-ray quiet FSRQs. Strong polarization at the base of the jet appears to be a signature for gamma-ray loud AGNs.

Searching the Gamma-Ray Sky for Counterparts to Gravitational Wave Sources Fermi Gamma-Ray Burst Monitor and Large Area Telescope Observations of LVT151012 and GW151226

Science.gov (United States)

Racusin, J. L.; Burns, E.; Goldstein, A.; Connaughton, V.; Wilson-Hodge, C. A.; Jenke, P.; Blackburn, L.; Briggs, M. S.; Broida, J.; Camp, J.;

CHARACTERISTICS OF GAMMA-RAY LOUD BLAZARS IN THE VLBA IMAGING AND POLARIMETRY SURVEY

International Nuclear Information System (INIS)

Linford, J. D.; Taylor, G. B.; Romani, R. W.; Healey, S. E.; Helmboldt, J. F.; Readhead, A. C. S.; Reeves, R.; Richards, J. L.; Cotter, G.

2011-01-01

The radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been observed as part of the VLBA Imaging and Polarimetry Survey. This large, flux-limited sample of active galactic nuclei (AGNs) provides insights into the mechanism that produces strong γ-ray emission. At lower flux levels, radio flux density does not directly correlate with γ-ray flux. We find that the LAT-detected BL Lac objects tend to be similar to the non-LAT BL Lac objects, but that the LAT-detected FSRQs are often significantly different from the non-LAT FSRQs. The differences between the γ-ray loud and quiet FSRQs can be explained by Doppler boosting; these objects appear to require larger Doppler factors than those of the BL Lac objects. It is possible that the γ-ray loud FSRQs are fundamentally different from the γ-ray quiet FSRQs. Strong polarization at the base of the jet appears to be a signature for γ-ray loud AGNs.

Characteristics of Gamma-ray Loud Blazars in the VLBA Imaging and Polarimetry Survey

Science.gov (United States)

Linford, J. D.; Taylor, G. B.; Romani, R. W.; Healey, S. E.; Helmboldt, J. F.; Readhead, A. C. S.; Reeves, R.; Richards, J. L.; Cotter, G.

2011-01-01

The radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been observed as part of the VLBA Imaging and Polarimetry Survey. This large, flux-limited sample of active galactic nuclei (AGNs) provides insights into the mechanism that produces strong γ-ray emission. At lower flux levels, radio flux density does not directly correlate with γ-ray flux. We find that the LAT-detected BL Lac objects tend to be similar to the non-LAT BL Lac objects, but that the LAT-detected FSRQs are often significantly different from the non-LAT FSRQs. The differences between the γ-ray loud and quiet FSRQs can be explained by Doppler boosting; these objects appear to require larger Doppler factors than those of the BL Lac objects. It is possible that the γ-ray loud FSRQs are fundamentally different from the γ-ray quiet FSRQs. Strong polarization at the base of the jet appears to be a signature for γ-ray loud AGNs.

Efeito de supressão nas vias auditivas: um estudo com os potenciais de média e longa latência Effect of suppression in the auditory pathways: a study with middle and long latency potentials

Directory of Open Access Journals (Sweden)

Mariana Buncana Simões

2009-03-01

Full Text Available OBJETIVO: avaliar o efeito de supressão no Potencial Evocado Auditivo de Média e Longa Latência em indivíduos sem alterações auditivas, com presença de emissões otoacústicas (EOA transientes em ambas as orelhas. MÉTODOS: foram avaliados 25 indivíduos (50 orelhas de 18 a 30 anos de idade, de ambos os sexos, utilizando-se os Potenciais Evocados Auditivos de Média e Longa latência sem e com ruído branco contralateral. Os sujeitos não apresentavam queixa relacionada ao Processamento Auditivo. Foram verificados e comparados os valores numéricos das latências e amplitudes das ondas na avaliação convencional sem ruído e com ruído contralateral. RESULTADOS: a média aritmética da amplitude de resposta na situação com ruído (mascaramento reduziu em todas as posições (C3/A1, C4/A1, C3/A2 e C4/A2, porém estes achados foram estatisticamente significantes nas posições C4/A1, C3/A2 e C4/A2. CONCLUSÃO: a diminuição da amplitude pode ter relação com o número de sinapses realizadas. O efeito de supressão na amplitude pode estar relacionado à ação do sistema eferente que suprime o número de sinapses neuronais.PURPOSE: to evaluate the suppression effect of the Middle Latency Response (MLR and Long Latency Potential on normal hearing individuals. METHODS: twenty-five individuals of both genders between 18 and 30-year old were evaluated (50 ears, with presence of OAE in both ears (thus, excluding any middle ear problem or hearing loss that could compromise the final evaluation. The individuals did not present any complain on the Auditory Processing. We used MLR and P300 with and with no contralateral white noise. The latency and amplitude of the waves were evaluated (with and with no noise and the results were compared. RESULTS: we found reduction in the median amplitude in the situation with noise (masking in all positions (C3/A1, C4/A1, C3/A2 and C4/A2. However, these findings had no statistically significant difference in

Defect-assisted tuning of electroluminescence from p-GaN/n-ZnO ...

Indian Academy of Sciences (India)

diodes (LEDs), major research is focused on tuning the emission colour so as to achieve white emission without the ... with the help of phosphors.4–6 ZnO is a wide band gap material ... and GaN have same crystal structure with very close lat-.

Hard X-ray emission spectroscopy with pink beam

Energy Technology Data Exchange (ETDEWEB)

Kvashnina, Kristina O.; Rossberg, Andre; Exner, Joerg; Scheinost, Andreas C. [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Molecular Structures

2017-06-01

Valence-band X-ray emission spectroscopy (XES) with a ''pink beam'', i.e. a beam with large energy bandwidth produced by a double-multilayer monochromator, is introduced here to overcome the weak count rate of monochromatic beams produced by conventional double-crystal monochromators. Our results demonstrate that - in spite of the large bandwidth in the order of 100 eV - the high spectral resolution of the Johann-type spectrometer is maintained, while the two orders of magnitude higher flux greatly reduces the required counting time. The short working distance Johann-type X-ray emission spectrometer and multilayer monochromator is available at ROBL.

Interregional differences of coal carbon dioxide emissions in China

International Nuclear Information System (INIS)

Chen, Jiandong; Cheng, Shulei; Song, Malin; Wang, Jia

2016-01-01

Coal is one of the main fuel sources in China. This paper sheds light on the evolution of China's interregional differences in CO 2 emissions from coal by constructing a Gini coefficient and decoupling elasticity index for emissions from 1997 to 2012 and explains why emission differences deviate from economic growth differences. The study decomposed the Gini coefficient of CO 2 emissions from coal by source, incremental source, and region. It also divided the decoupling elasticity of carbon emissions into two components: effects of environmental expenditure and effects of emission reduction policy. The findings of the study are as follows: First, interregional differences in China's overall CO 2 emissions from coal are characterized by periodic fluctuation. Second, the differences in emissions from raw coal, the concentration effect of emissions, and the emission differences within regions are the three main factors in the overall difference changes in coal's carbon emissions in China. Last but not least, the decoupling between provincial CO 2 emissions from coal and economic growth is on the whole weak. Based on the above findings, the author offers four suggestions for emission reduction. - Highlights: •We focus on interregional differences in China's coal carbon dioxide emissions. •We construct an emission decoupling elasticity index. •Expenditure on environmental protection is the intermediate variable for the index. •We use the Gini coefficient to decompose emissions by source and incremental source. •Interregional emission and economic growth differences deviate due to govt. policy.

Modeling the Broad-Band Emission from the Gamma-Ray Emitting Narrow-Line Seyfert-1 Galaxies 1H 0323+342 and B2 0954+25A

International Nuclear Information System (INIS)

Arrieta-Lobo, Maialen; Boisson, Catherine; Zech, Andreas

2017-01-01

Prior to the Fermi-LAT era, only two classes of Active Galactic Nuclei (AGN) were thought to harbor relativistic jets that radiate up to gamma-ray energies: blazars and radio galaxies. The detection of variable gamma-ray emission from Narrow Line Seyfert 1 (NLSy1) galaxies has put them on the spotlight as a new class of gamma-ray emitting AGN. In this respect, gamma-ray emitting NLSy1s seem to be situated between blazars (dominated by non-thermal emission) and Seyferts (accretion disc dominated). In this work, we model the Spectral Energy Distribution (SED) of two gamma-loud NLSy1s, 1H 0323+342 and B2 0954+25A, during quiescent and flaring episodes via a multi-component radiative model that features a relativistic jet and external photon fields from the torus, disc, corona and Broad Line Region (BLR). We find that the interpretation of the high-energy emission of jetted NLSy1s requires taking into account Inverse Compton emission from particles in the relativistic jet that interact with external photon fields. Minimal changes are applied to the model parameters to transition from average to flaring states. In this scenario, the observed variability is explained mainly by means of changes in the jet density and Doppler factor.

Modeling the Broad-Band Emission from the Gamma-Ray Emitting Narrow-Line Seyfert-1 Galaxies 1H 0323+342 and B2 0954+25A

Energy Technology Data Exchange (ETDEWEB)

Arrieta-Lobo, Maialen; Boisson, Catherine; Zech, Andreas, E-mail: maialen.arrieta@obspm.fr [Laboratoire Univers et Theories, Observatoire de Paris, CNRS, Université Paris-Diderot, PSL Research University, Meudon (France)

2017-12-08

Prior to the Fermi-LAT era, only two classes of Active Galactic Nuclei (AGN) were thought to harbor relativistic jets that radiate up to gamma-ray energies: blazars and radio galaxies. The detection of variable gamma-ray emission from Narrow Line Seyfert 1 (NLSy1) galaxies has put them on the spotlight as a new class of gamma-ray emitting AGN. In this respect, gamma-ray emitting NLSy1s seem to be situated between blazars (dominated by non-thermal emission) and Seyferts (accretion disc dominated). In this work, we model the Spectral Energy Distribution (SED) of two gamma-loud NLSy1s, 1H 0323+342 and B2 0954+25A, during quiescent and flaring episodes via a multi-component radiative model that features a relativistic jet and external photon fields from the torus, disc, corona and Broad Line Region (BLR). We find that the interpretation of the high-energy emission of jetted NLSy1s requires taking into account Inverse Compton emission from particles in the relativistic jet that interact with external photon fields. Minimal changes are applied to the model parameters to transition from average to flaring states. In this scenario, the observed variability is explained mainly by means of changes in the jet density and Doppler factor.

Fine structures in hearing thresholds and distortion product otoacoustic emissions

DEFF Research Database (Denmark)

Hammershøi, Dorte; Ordoñez, Rodrigo Pizarro; Torrente, Marina

2010-01-01

Otoacoustic emissions (OAEs) are weak sounds that can be recorded in the external ear. They are generated by the active amplification of the outer hair cells, and are by many believed to reflect the status of the most vulnerable part of the hearing better than ordinary behavioral thresholds. Dist...

Classical field approach to quantum weak measurements.

Science.gov (United States)

Dressel, Justin; Bliokh, Konstantin Y; Nori, Franco

2014-03-21

By generalizing the quantum weak measurement protocol to the case of quantum fields, we show that weak measurements probe an effective classical background field that describes the average field configuration in the spacetime region between pre- and postselection boundary conditions. The classical field is itself a weak value of the corresponding quantum field operator and satisfies equations of motion that extremize an effective action. Weak measurements perturb this effective action, producing measurable changes to the classical field dynamics. As such, weakly measured effects always correspond to an effective classical field. This general result explains why these effects appear to be robust for pre- and postselected ensembles, and why they can also be measured using classical field techniques that are not weak for individual excitations of the field.

Polarized Gamma-Ray Emission from the Galactic Black Hole Cygnus X-1

Science.gov (United States)

Laurent, P.; Rodriquez, J.; Wilms, J.; Bel, M. Cadolle; Pottschmidt, K.; Grinberg, V.

2011-01-01

Because of their inherently high flux allowing the detection of clear signals, black hole X-ray binaries are interesting candidates for polarization studies, even if no polarization signals have been observed from them before. Such measurements would provide further detailed insight into these sources' emission mechanisms. We measured the polarization of the gamma-ray emission from the black hole binary system Cygnus X-I with the INTEGRAL/IBIS telescope. Spectral modeling ofthe data reveals two emission mechanisms: The 250-400 keY data are consistent with emission dominated by Compton scattering on thermal electrons and are weakly polarized. The second spectral component seen in the 400keV-2MeV band is by contrast strongly polarized, revealing that the MeV emission is probably related to the jet first detected in the radio band.

HDE 245059: A WEAK-LINED T TAURI BINARY REVEALED BY CHANDRA AND KECK

International Nuclear Information System (INIS)

Baldovin-Saavedra, C.; Audard, M.; Duchene, G.; Guedel, M.; Skinner, S.L.; Paerels, F. B. S.; Ghez, A.; McCabe, C.

2009-01-01

We present the Chandra High Energy Transmission Grating Spectrometer and Keck observations of HDE 245059, a young weak-lined T Tauri star (WTTS), member of the pre-main-sequence group in the λ Orionis Cluster. Our high spatial resolution, near-infrared observations with Keck reveal that HDE 245059 is in fact a binary separated by 0.''87, probably composed of two WTTS based on their color indices. Based on this new information we have obtained an estimate of the masses of the binary components; ∼3 M sun and ∼2.5 M sun for the north and south components, respectively. We have also estimated the age of the system to be ∼2-3 Myr. We detect both components of the binary in the zeroth-order Chandra image and in the grating spectra. The light curves show X-ray variability of both sources and in particular a flaring event in the weaker southern component. The spectra of both stars show similar features: a combination of cool and hot plasma as demonstrated by several iron lines from Fe XVII to Fe XXV and a strong bremsstrahlung continuum at short wavelengths. We have fitted the combined grating and zeroth-order spectrum (considering the contribution of both stars) in XSPEC. The coronal abundances and emission measure distribution for the binary have been obtained using different methods, including a continuous emission measure distribution and a multi-temperature approximation. In all cases we have found that the emission is dominated by plasma between ∼8 and ∼15 MK a soft component at ∼4 MK and a hard component at ∼50 MK are also detected. The value of the hydrogen column density was low, N H ∼ 8 x 10 19 cm -2 , likely due to the clearing of the inner region of the λ Orionis cloud, where HDE 245059 is located. The abundance pattern shows an inverse first ionization potential effect for all elements from O to Fe, the only exception being Ca. To obtain the properties of the binary components, a 3-T model was fitted to the individual zeroth-order spectra

Peripheral facial weakness (Bell's palsy).

Science.gov (United States)

Basić-Kes, Vanja; Dobrota, Vesna Dermanović; Cesarik, Marijan; Matovina, Lucija Zadro; Madzar, Zrinko; Zavoreo, Iris; Demarin, Vida

2013-06-01

Peripheral facial weakness is a facial nerve damage that results in muscle weakness on one side of the face. It may be idiopathic (Bell's palsy) or may have a detectable cause. Almost 80% of peripheral facial weakness cases are primary and the rest of them are secondary. The most frequent causes of secondary peripheral facial weakness are systemic viral infections, trauma, surgery, diabetes, local infections, tumor, immune disorders, drugs, degenerative diseases of the central nervous system, etc. The diagnosis relies upon the presence of typical signs and symptoms, blood chemistry tests, cerebrospinal fluid investigations, nerve conduction studies and neuroimaging methods (cerebral MRI, x-ray of the skull and mastoid). Treatment of secondary peripheral facial weakness is based on therapy for the underlying disorder, unlike the treatment of Bell's palsy that is controversial due to the lack of large, randomized, controlled, prospective studies. There are some indications that steroids or antiviral agents are beneficial but there are also studies that show no beneficial effect. Additional treatments include eye protection, physiotherapy, acupuncture, botulinum toxin, or surgery. Bell's palsy has a benign prognosis with complete recovery in about 80% of patients, 15% experience some mode of permanent nerve damage and severe consequences remain in 5% of patients.

Weakly oval electron lense

International Nuclear Information System (INIS)

Daumenov, T.D.; Alizarovskaya, I.M.; Khizirova, M.A.

2001-01-01

The method of the weakly oval electrical field getting generated by the axially-symmetrical field is shown. Such system may be designed with help of the cylindric form coaxial electrodes with the built-in quadrupole duplet. The singularity of the indicated weakly oval lense consists of that it provides the conducting both mechanical and electronic adjustment. Such lense can be useful for elimination of the near-axis astigmatism in the electron-optical system

The Another Assimilation System for WRF-Chem (AAS4WRF): a new mass-conserving emissions pre-processor for WRF-Chem regional modelling

Science.gov (United States)

Vara Vela, A. L.; Muñoz, A.; Lomas, A., Sr.; González, C. M.; Calderon, M. G.; Andrade, M. D. F.

2017-12-01

The Weather Research and Forecasting with Chemistry (WRF-Chem) community model have been widely used for the study of pollutants transport, formation of secondary pollutants, as well as for the assessment of air quality policies implementation. A key factor to improve the WRF-Chem air quality simulations over urban areas is the representation of anthropogenic emission sources. There are several tools that are available to assist users in creating their own emissions based on global emissions information (e.g. anthro_emiss, prep_chem_src); however, there is no single tool that will construct local emissions input datasets for any particular domain at this time. Because the official emissions pre-processor (emiss_v03) is designed to work with domains located over North America, this work presents the Another Assimilation System for WRF-Chem (AAS4WRF), a ncl based mass-conserving emissions pre-processor designed to create WRF-Chem ready emissions files from local inventories on a lat/lon projection. AAS4WRF is appropriate to scale emission rates from both surface and elevated sources, providing the users an alternative way to assimilate their emissions to WRF-Chem. Since it was successfully tested for the first time for the city of Lima, Peru in 2014 (managed by SENAMHI, the National Weather Service of the country), several studies on air quality modelling have applied this utility to convert their emissions to those required for WRF-Chem. Two case studies performed in the metropolitan areas of Sao Paulo and Manizales in Brazil and Colombia, respectively, are here presented in order to analyse the influence of using local or global emission inventories in the representation of regulated air pollutants such as O3 and PM2.5. Although AAS4WRF works with local emissions information at the moment, further work is being conducted to make it compatible with global/regional emissions data file format. The tool is freely available upon request to the corresponding author.