Reconstruction of global gridded monthly sectoral water withdrawals for 1971–2010 and analysis of their spatiotemporal patterns

Directory of Open Access Journals (Sweden)

Z. Huang

2018-04-01

Full Text Available Human water withdrawal has increasingly altered the global water cycle in past decades, yet our understanding of its driving forces and patterns is limited. Reported historical estimates of sectoral water withdrawals are often sparse and incomplete, mainly restricted to water withdrawal estimates available at annual and country scales, due to a lack of observations at seasonal and local scales. In this study, through collecting and consolidating various sources of reported data and developing spatial and temporal statistical downscaling algorithms, we reconstruct a global monthly gridded (0.5° sectoral water withdrawal dataset for the period 1971–2010, which distinguishes six water use sectors, i.e., irrigation, domestic, electricity generation (cooling of thermal power plants, livestock, mining, and manufacturing. Based on the reconstructed dataset, the spatial and temporal patterns of historical water withdrawal are analyzed. Results show that total global water withdrawal has increased significantly during 1971–2010, mainly driven by the increase in irrigation water withdrawal. Regions with high water withdrawal are those densely populated or with large irrigated cropland production, e.g., the United States (US, eastern China, India, and Europe. Seasonally, irrigation water withdrawal in summer for the major crops contributes a large percentage of total annual irrigation water withdrawal in mid- and high-latitude regions, and the dominant season of irrigation water withdrawal is also different across regions. Domestic water withdrawal is mostly characterized by a summer peak, while water withdrawal for electricity generation has a winter peak in high-latitude regions and a summer peak in low-latitude regions. Despite the overall increasing trend, irrigation in the western US and domestic water withdrawal in western Europe exhibit a decreasing trend. Our results highlight the distinct spatial pattern of human water use by sectors at

Optimizing withdrawal from drinking water reservoirs to reduce downstream temperature pollution and reservoir hypoxia.

Science.gov (United States)

Weber, M; Rinke, K; Hipsey, M R; Boehrer, B

2017-07-15

Sustainable management of drinking water reservoirs requires balancing the demands of water supply whilst minimizing environmental impact. This study numerically simulates the effect of an improved withdrawal scheme designed to alleviate the temperature pollution downstream of a reservoir. The aim was to identify an optimal withdrawal strategy such that water of a desirable discharge temperature can be supplied downstream without leading to unacceptably low oxygen concentrations within the reservoir. First, we calibrated a one-dimensional numerical model for hydrodynamics and oxygen dynamics (GLM-AED2), verifying that the model reproduced water temperatures and hypolimnetic dissolved oxygen concentrations accurately over a 5 year period. Second, the model was extended to include an adaptive withdrawal functionality, allowing for a prescribed withdrawal temperature to be found, with the potential constraint of hypolimnetic oxygen concentration. Scenario simulations on epi-/metalimnetic withdrawal demonstrate that the model is able to autonomously determine the best withdrawal height depending on the thermal structure and the hypolimnetic oxygen concentration thereby optimizing the ability to supply a desirable discharge temperature to the downstream river during summer. This new withdrawal strategy also increased the hypolimnetic raw water volume to be used for drinking water supply, but reduced the dissolved oxygen concentrations in the deep and cold water layers (hypolimnion). Implications of the results for reservoir management are discussed and the numerical model is provided for operators as a simple and efficient tool for optimizing the withdrawal strategy within different reservoir contexts. Copyright © 2017 Elsevier Ltd. All rights reserved.

78 FR 20252 - Water Quality Standards; Withdrawal of Certain Federal Water Quality Criteria Applicable to...

Science.gov (United States)

2013-04-04

... Water Quality Standards; Withdrawal of Certain Federal Water Quality Criteria Applicable to California... aquatic life water quality criteria applicable to waters of New Jersey, Puerto Rico, and California's San Francisco Bay. In 1992, EPA promulgated the National Toxics Rule or NTR to establish numeric water quality...

76 FR 57646 - Final Withdrawal of Certain Federal Aquatic Life Water Quality Criteria Applicable to Wisconsin

Science.gov (United States)

2011-09-16

... Final Withdrawal of Certain Federal Aquatic Life Water Quality Criteria Applicable to Wisconsin AGENCY... aquatic life water quality criteria applicable to Wisconsin? C. Why is the EPA not withdrawing Wisconsin's chronic endrin aquatic life use criterion for waters designated as Warm Water Sportfish and Warm Water...

Operational water consumption and withdrawal factors for electricity generating technologies: a review of existing literature

International Nuclear Information System (INIS)

Macknick, J; Newmark, R; Heath, G; Hallett, K C

2012-01-01

This report provides estimates of operational water withdrawal and water consumption factors for electricity generating technologies in the United States. Estimates of water factors were collected from published primary literature and were not modified except for unit conversions. The water factors presented may be useful in modeling and policy analyses where reliable power plant level data are not available. Major findings of the report include: water withdrawal and consumption factors vary greatly across and within fuel technologies, and water factors show greater agreement when organized according to cooling technologies as opposed to fuel technologies; a transition to a less carbon-intensive electricity sector could result in either an increase or a decrease in water use, depending on the choice of technologies and cooling systems employed; concentrating solar power technologies and coal facilities with carbon capture and sequestration capabilities have the highest water consumption values when using a recirculating cooling system; and non-thermal renewables, such as photovoltaics and wind, have the lowest water consumption factors. Improved power plant data and further studies into the water requirements of energy technologies in different climatic regions would facilitate greater resolution in analyses of water impacts of future energy and economic scenarios. This report provides the foundation for conducting water use impact assessments of the power sector while also identifying gaps in data that could guide future research. (letter)

Impacts of impervious cover, water withdrawals, and climate change on river flows in the conterminous US

Directory of Open Access Journals (Sweden)

P. V. Caldwell

2012-08-01

Full Text Available Rivers are essential to aquatic ecosystem and societal sustainability, but are increasingly impacted by water withdrawals, land-use change, and climate change. The relative and cumulative effects of these stressors on continental river flows are relatively unknown. In this study, we used an integrated water balance and flow routing model to evaluate the impacts of impervious cover and water withdrawal on river flow across the conterminous US at the 8-digit Hydrologic Unit Code (HUC watershed scale. We then estimated the impacts of projected change in withdrawals, impervious cover, and climate under the B1 "Low" and A2 "High" emission scenarios on river flows by 2060. Our results suggest that compared to no impervious cover, 2010 levels of impervious cover increased river flows by 9.9% on average with larger impacts in and downstream of major metropolitan areas. In contrast, compared to no water withdrawals, 2005 withdrawals decreased river flows by 1.4% on average with larger impacts in heavily irrigated arid regions of Western US. By 2060, impacts of climate change were predicted to overwhelm the potential gain in river flow due to future changes in impervious cover and add to the potential reduction in river flows from withdrawals, decreasing mean annual river flows from 2010 levels by 16% on average. However, increases in impervious cover by 2060 may offset the impact of climate change during the growing season in some watersheds. Large water withdrawals will aggravate the predicted impact of climate change on river flows, particularly in the Western US. Predicted ecohydrological impacts of land cover, water withdrawal, and climate change will likely include alteration of the terrestrial water balance, stream channel habitat, riparian and aquatic community structure in snow-dominated basins, and fish and mussel extirpations in heavily impacted watersheds. These changes may also require new infrastructure to support increasing anthropogenic

18 CFR 430.19 - Ground water withdrawal metering, recording, and reporting.

Science.gov (United States)

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Ground water withdrawal metering, recording, and reporting. 430.19 Section 430.19 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION SPECIAL REGULATIONS GROUND WATER PROTECTION AREA: PENNSYLVANIA § 430.19...

Optimization of ground-water withdrawal in the lower Fox River communities, Wisconsin

Science.gov (United States)

Walker, J.F.; Saad, D.A.; Krohelski, J.T.

1998-01-01

Pumping from closely spaced wells in the Central Brown County area and the Fox Cities area near the north shore of Lake Winnebago has resulted in the formation of deep cones of depression in the vicinity of the two pumping centers. Water-level measurements indicate there has been a steady decline in water levels in the vicinity of these two pumping centers for the past 50 years. This report describes the use of ground-water optimization modeling to efficiently allocate the ground-water resources in the Lower Fox River Valley. A 3-dimensional ground-water flow model was used along with optimization techniques to determine the optimal withdrawal rates for a variety of management alternatives. The simulations were conducted separately for the Central Brown County area and the Fox Cities area. For all simulations, the objective of the optimization was to maximize total ground-water withdrawals. The results indicate that ground water can supply nearly all of the projected 2030 demand for Central Brown County municipalities if all of the wells are managed (including the city of Green Bay), 8 new wells are installed, and the water-levels are allowed to decline to 100 ft below the bottom of the confining unit. Ground water can supply nearly all of the projected 2030 demand for the Fox Cities if the municipalities in Central Brown County convert to surface water; if Central Brown County municipalities follow the optimized strategy described above, there will be a considerable shortfall of available ground water for the Fox Cities communities. Relaxing the water-level constraint in a few wells, however, would likely result in increased availability of water. In all cases examined, optimization alternatives result in a rebound of the steady-state water levels due to projected 2030 withdrawal rates to levels at or near the bottom of the confining unit, resulting in increased well capacity. Because the simulations are steady-state, if all of the conditions of the model remain

76 FR 14351 - Proposed Withdrawal of Certain Federal Aquatic Life Water Quality Criteria Applicable to Wisconsin

Science.gov (United States)

2011-03-16

... Proposed Withdrawal of Certain Federal Aquatic Life Water Quality Criteria Applicable to Wisconsin AGENCY... aquatic life water quality criteria for chronic and acute copper and nickel, and chronic endrin and...., Washington, DC 20460 or Francine Norling, Proposed Withdrawal of Certain Federal Aquatic Life Water Quality...

Demand-driven water withdrawals by Chinese industry: a multi-regional input-output analysis

Science.gov (United States)

Zhang, Bo; Chen, Z. M.; Zeng, L.; Qiao, H.; Chen, B.

2016-03-01

With ever increasing water demands and the continuous intensification of water scarcity arising from China's industrialization, the country is struggling to harmonize its industrial development and water supply. This paper presents a systems analysis of water withdrawals by Chinese industry and investigates demand-driven industrial water uses embodied in final demand and interregional trade based on a multi-regional input-output model. In 2007, the Electric Power, Steam, and Hot Water Production and Supply sector ranks first in direct industrial water withdrawal (DWW), and Construction has the largest embodied industrial water use (EWU). Investment, consumption, and exports contribute to 34.6%, 33.3%, and 30.6% of the national total EWU, respectively. Specifically, 58.0%, 51.1%, 48.6%, 43.3%, and 37.5% of the regional EWUs respectively in Guangdong, Shanghai, Zhejiang, Jiangsu, and Fujian are attributed to international exports. The total interregional import/export of embodied water is equivalent to about 40% of the national total DWW, of which 55.5% is associated with the DWWs of Electric Power, Steam, and Hot Water Production and Supply. Jiangsu is the biggest interregional exporter and deficit receiver of embodied water, in contrast to Guangdong as the biggest interregional importer and surplus receiver. Without implementing effective water-saving measures and adjusting industrial structures, the regional imbalance between water availability and water demand tends to intensify considering the water impact of domestic trade of industrial products. Steps taken to improve water use efficiency in production, and to enhance embodied water saving in consumption are both of great significance for supporting China's water policies.

A comparison of three federal datasets for thermoelectric water withdrawals in the United States for 2010

Science.gov (United States)

Harris, Melissa A.; Diehl, Timothy H.

2017-01-01

Historically, thermoelectric water withdrawal has been estimated by the Energy Information Administration (EIA) and the U.S. Geological Survey's (USGS) water-use compilations. Recently, the USGS developed models for estimating withdrawal at thermoelectric plants to provide estimates independent from plant operator-reported withdrawal data. This article compares three federal datasets of thermoelectric withdrawals for the United States in 2010: one based on the USGS water-use compilation, another based on EIA data, and the third based on USGS model-estimated data. The withdrawal data varied widely. Many plants had three different withdrawal values, and for approximately 54% of the plants the largest withdrawal value was twice the smallest, or larger. The causes of discrepancies among withdrawal estimates included definitional differences, definitional noise, and various nondefinitional causes. The uncertainty in national totals can be characterized by the range among the three datasets, from 5,640 m3/s (129 billion gallons per day [bgd]) to 6,954 m3/s (158 bgd), or by the aggregate difference between the smallest and largest values at each plant, from 4,014 m3/s (92 bgd) to 8,590 m3/s (196 bgd). When used to assess the accuracy of reported values, the USGS model estimates identify plants that need to be reviewed.

Simulating the effects of ground-water withdrawals on streamflow in a precipitation-runoff model

Science.gov (United States)

Zarriello, Philip J.; Barlow, P.M.; Duda, P.B.

2004-01-01

Precipitation-runoff models are used to assess the effects of water use and management alternatives on streamflow. Often, ground-water withdrawals are a major water-use component that affect streamflow, but the ability of surface-water models to simulate ground-water withdrawals is limited. As part of a Hydrologic Simulation Program-FORTRAN (HSPF) precipitation-runoff model developed to analyze the effect of ground-water and surface-water withdrawals on streamflow in the Ipswich River in northeastern Massachusetts, an analytical technique (STRMDEPL) was developed for calculating the effects of pumped wells on streamflow. STRMDEPL is a FORTRAN program based on two analytical solutions that solve equations for ground-water flow to a well completed in a semi-infinite, homogeneous, and isotropic aquifer in direct hydraulic connection to a fully penetrating stream. One analytical method calculates unimpeded flow at the stream-aquifer boundary and the other method calculates the resistance to flow caused by semipervious streambed and streambank material. The principle of superposition is used with these analytical equations to calculate time-varying streamflow depletions due to daily pumping. The HSPF model can readily incorporate streamflow depletions caused by a well or surface-water withdrawal, or by multiple wells or surface-water withdrawals, or both, as a combined time-varying outflow demand from affected channel reaches. These demands are stored as a time series in the Watershed Data Management (WDM) file. This time-series data is read into the model as an external source used to specify flow from the first outflow gate in the reach where these withdrawals are located. Although the STRMDEPL program can be run independently of the HSPF model, an extension was developed to run this program within GenScn, a scenario generator and graphical user interface developed for use with the HSPF model. This extension requires that actual pumping rates for each well be stored

Effect of selective withdrawal on the annual thermal regime of a deep water body

International Nuclear Information System (INIS)

Bocharov, O.B.; Zinov'ev, A.T.

1993-01-01

The construction of any large hydraulic structure leads to the occurrence of new ecosystems in the upper and lower pools of the hydro development. A study of scenarios of the development of these ecosystems and an investigation of the possibilities of minimizing the negative ecological consequences of waterpower engineering by means of mathematical modeling in many respects determine the quality of developing the scientific and technical project. For high-head hydroelectric stations, an effective tool for controlling the water quality in the upper and lower pools is the withdrawal of water form different horizons of the upper pool reservoir. Temperature stratification of a deep sluggish water body is modeled in a one-dimensional vertical approximation with the use of an improved method of describing fluid outflow. The effect of selective withdrawal on the annual thermal regime and temperature of the outflowing water was studied. The results obtained permit estimating the effect of selective withdrawal on the thermal regime of the upper pool of the planned hydro development and temperature of the water being discharged into the lower pool on the possibility, in principle, of the water temperature in the lower pool approaching the natural both in winter and summer

Global modeling of withdrawal, allocation and consumptive use of surface water and groundwater resources

NARCIS (Netherlands)

Wada, Y.; Wisser, D.; Bierkens, M. F. P.

2014-01-01

To sustain growing food demand and increasing standard of living, global water withdrawal and consumptive water use have been increasing rapidly. To analyze the human perturbation on water resources consistently over large scales, a number of macro-scale hydrological models (MHMs) have been

Tomographic Imaging of Water Injection and Withdrawal in PEMFC Gas Diffusion Layers

Energy Technology Data Exchange (ETDEWEB)

McGill U; Gostick, J. T.; Gunterman, H. P.; Weber, A. Z.; Newman, J. S.; Kienitz, B. L.; MacDowell, A. A.

2010-06-25

X-ray computed tomography was used to visualize the water configurations inside gas diffusion layers for various applied capillary pressures, corresponding to both water invasion and withdrawal. A specialized sample holder was developed to allow capillary pressure control on the small-scale samples required. Tests were performed on GDL specimens with and without hydrophobic treatments.

Global modeling of withdrawal, allocation and consumptive use of surface water and groundwater resources

NARCIS (Netherlands)

Wada, Y.; Wisser, D.; Bierkens, M.F.P.

2013-01-01

To sustain growing food demand and increasing standard of living, global water withdrawal and consumptive water use have been increasing rapidly. To analyze the human perturbation on water resources consistently over a large scale, a number of macro-scale hydrological models (MHMs) have been

Simulated effects of groundwater withdrawals from the Kirkwood-Cohansey aquifer system and Piney Point aquifer, Maurice and Cohansey River Basins, Cumberland County and vicinity, New Jersey

Science.gov (United States)

Gordon, Alison D.; Buxton, Debra E.

2018-05-10

The U.S. Geological Survey, in cooperation with the New Jersey Department of Environmental Protection, conducted a study to simulate the effects of withdrawals from the Kirkwood-Cohansey aquifer system on streamflow and groundwater flow and from the Piney Point aquifer on water levels in the Cohansey and Maurice River Basins in Cumberland County and surrounding areas. The aquifer system consists of gravel, sand, silt, and clay sediments of the Cohansey Sand and Kirkwood Formation that dip and thicken to the southeast. The aquifer system is generally an unconfined aquifer, but semi-confined and confined conditions exist within the Cumberland County study area. The Kirkwood-Cohansey aquifer system is present throughout Cumberland County and is the principal source of groundwater for public, domestic, agricultural-irrigation, industrial, and commercial water uses. In 2008, reported groundwater withdrawals from the Kirkwood-Cohansey aquifer system in the study area totaled about 21,700 million gallons—about 36 percent for public supply; about 49 percent for agricultural irrigation; and about 15 percent for industrial, commercial, mining by sand and gravel companies, and non-agricultural irrigation uses. A transient numerical groundwater-flow model of the Kirkwood-Cohansey aquifer system was developed and calibrated by incorporating monthly recharge, base-flow estimates, water-level data, surface-water diversions and discharges, and groundwater withdrawals from 1998 to 2008.The groundwater-flow model was used to simulate five withdrawal scenarios to observe the effects of additional groundwater withdrawals on the Kirkwood-Cohansey aquifer system and streams. These scenarios include (1) average 1998 to 2008 monthly groundwater withdrawals (baseline scenario); (2) monthly full-allocation groundwater withdrawals, but agricultural-irrigation withdrawals were decreased for October through March; (3) monthly full-allocation groundwater withdrawals; (4) estimated monthly

Simulation of the Effects of Water Withdrawals, Wastewater Return Flows, and Land-Use Change on Streamflow in the Blackstone River Basin, Massachusetts and Rhode Island

Science.gov (United States)

Barbaro, Jeffrey R.

2007-01-01

. Ratios of long-term (1960?2004) simulated flows with 1996?2001 water use (representing the net effect of withdrawals and wastewater-return flows) to long-term simulated flows with no water use indicated that, for many reaches, 1996?2001 water use did not deplete flows at the 90-percent flow duration substantially compared to flows unaffected by water use. Flows generally were more severely depleted in the reaches that include surface-water supplies for the larger cities in the basin (Kettle and Tatnuck Brooks, Worcester, Mass. water supply; Quinsigamond River, Shrewsbury, Mass. water supply; Crookfall Brook, Woonsocket, R.I. water supply; and Abbott Run, Pawtucket, R.I. water supply). These reaches did not have substantial wastewater-return flows that could offset the effects of the withdrawals. In contrast, wastewater-return flows from the Upper Blackstone Wastewater Treatment Facility in Millbury, Mass. increased flows at the 90-percent flow duration in the main stem of the Blackstone River compared to no-water-use conditions. Under the assumptions used to develop the buildout scenario, nearly all of the new water withdrawals were returned to the Blackstone River Basin at municipal wastewater-treatment plants or on-site septic systems. Consequently, buildout generally had small effects on simulated low flows in the Blackstone River and most of the major tributary streams compared to flows with 1996?2001 water use. To evaluate the effects of water use on flows in the rivers and major tributary streams in the Rhode Island part of the basin in greater detail, the magnitudes of water withdrawals and wastewater-return flows in relation to simulated streamflow were calculated as unique ratios for individual HSPF subbasins, total contributing areas to HSPF subbasins, and total contributing areas to the major tributary streams. For recent conditions (1996?2001 withdrawals and 1995?1999 land use), ratios of average summer (June through September) withdrawals to the l

Public-supply water use and self-supplied industrial water use in Tennessee, 2010

Science.gov (United States)

Robinson, John A.

2018-04-26

The U.S. Geological Survey (USGS), in cooperation with the Tennessee Department of Environment and Conservation, Division of Water Resources, prepared this report and displayed and analyzed water use by self-supplied industrial and public-supply water systems in Tennessee for 2010. Public-supply water systems in Tennessee provide water for domestic, industrial, and commercial uses and for municipal services. In 2010, 474 public-supply water systems distributed 917 million gallons per day (Mgal/d) of surface water (67 percent, 617 Mgal/d) and groundwater (33 percent, 300 Mgal/d) to a population of 5.7 million in Tennessee. Gross per capita water use in Tennessee during 2010 was 162 gallons per day.Since 1950, water withdrawals by public-supply water systems in Tennessee have increased from 160 Mgal/d to 917 Mgal/d in 2010. Each of the 95 counties in Tennessee was served by at least 1 public-supply water system in 2010. Tennessee public-supply water systems withdraw less groundwater than surface water, and surface-water use has increased at a faster rate than groundwater use. Since 2005, surface-water withdrawals have increased by 26 Mgal/d, and groundwater withdrawals have decreased by 29 Mgal/d, which is the first decrease in groundwater withdrawals since 1950; however, 29 systems reported increased groundwater withdrawals during 2010, and 12 of these 29 systems reported increases of 1 Mgal/d or more. Davidson County had the largest surface-water withdrawal rate (136 Mgal/d) in 2010. The largest groundwater withdrawal rate (151 Mgal/d) by a single public-supply water system was reported by Memphis Light, Gas and Water, which served more than 669,000 people in Shelby County in 2010.Self-supplied industrial water use includes water for such purposes as fabrication, processing, washing, diluting, cooling, or transporting a product; incorporating water into a product; or for sanitation needs in facilities that manufacture various products. Water withdrawals for self

Variations in Withdrawal, Return Flow, and Consumptive Use of Water in Ohio and Indiana, with Selected Data from Wisconsin, 1999-2004

Science.gov (United States)

Shaffer, Kimberly H.

2009-01-01

This report contains an analysis of water withdrawal and return-flow data for Ohio and withdrawal data for Indiana and Wisconsin to compute consumptive-use coefficients and to describe monthly variability of withdrawals and consumptive use. Concurrent data were available for most water-use categories from 1999 through 2004. Average monthly water withdrawals are discussed for a variety of water-use categories, and average water use per month is depicted graphically for Ohio, Indiana, and Wisconsin (public supply only). For most water-use categories, the summer months were those of highest withdrawal and highest consumptive use. For public supply, average monthly withdrawals ranged from 1,380 million gallons per day (Mgal/d) (November) to 1,620 Mgal/d (July) in Ohio, 621 Mgal/d (December) to 816 Mgal/d (July) in Indiana, and 515 Mgal/d (December) to 694 Mgal/d (July) in Wisconsin. Ohio and Indiana thermoelectric facilities had large increases in average monthly withdrawals in the summer months (5,520 Mgal/d in March to 7,510 Mgal/d in August for Indiana; 7,380 Mgal/d in February to 10,040 Mgal/d in July for Ohio), possibly because of increased electricity production in the summer, a need for additional cooling-water withdrawals when intake-water temperature is high, or use of different types of cooling methods during different times of the year. Average industrial withdrawals ranged from 2,220 Mgal/d (December) to 2,620 Mgal/d (August) in Indiana and from 707 Mgal/d (January) to 787 Mgal/d (August) in Ohio. The Ohio and Indiana irrigation data showed that most withdrawals were in May through October for golf courses, nurseries, and crop irrigation. Commercial water withdrawals ranged from 30.4 Mgal/d (January) to 65.0 Mgal/d (September) in Indiana and from 23.2 Mgal/d (November) to 49.5 Mgal/d (August) in Ohio; commercial facilities that have high water demand in Ohio and Indiana are medical facilities, schools, amusement facilities, wildlife facilities, large stores

18 CFR 430.13 - Protected area permits for new withdrawals.

Science.gov (United States)

2010-04-01

... space heating or cooling that are subsequently used for commercial or industrial water supply purposes... against significant leaks of refrigerant, all ground water heat pump systems shall be equipped with an... resource requirements; evaluate supply-side and demand-side alternatives to meet water withdrawal needs...

Life-cycle and freshwater withdrawal impact assessment of water supply technologies

DEFF Research Database (Denmark)

Godskesen, Berit; Hauschild, Michael Zwicky; Rygaard, Martin

2013-01-01

Four alternative cases for water supply were environmentally evaluated and compared based on the standard environmental impact categories from the life-cycle assessment (LCA) methodology extended with a freshwater withdrawal category (FWI). The cases were designed for Copenhagen, a part of Denmark...... with high population density and relatively low available water resources. FWI was applied at local groundwater catchments based on data from the national implementation of the EU Water Framework Directive. The base case of the study was the current practice of groundwater abstraction from well fields...... situated near Copenhagen. The 4 cases studied were: Rain & stormwater harvesting from several blocks in the city; Today's groundwater abstraction with compensating actions applied in the affected freshwater environments to ensure sufficient water flow in water courses; Establishment of well fields further...

Operational cost minimization in cooling water systems

Directory of Open Access Journals (Sweden)

Castro M.M.

2000-01-01

Full Text Available In this work, an optimization model that considers thermal and hydraulic interactions is developed for a cooling water system. It is a closed loop consisting of a cooling tower unit, circulation pump, blower and heat exchanger-pipe network. Aside from process disturbances, climatic fluctuations are considered. Model constraints include relations concerning tower performance, air flowrate requirement, make-up flowrate, circulating pump performance, heat load in each cooler, pressure drop constraints and climatic conditions. The objective function is operating cost minimization. Optimization variables are air flowrate, forced water withdrawal upstream the tower, and valve adjustment in each branch. It is found that the most significant operating cost is related to electricity. However, for cooled water temperatures lower than a specific target, there must be a forced withdrawal of circulating water and further makeup to enhance the cooling tower capacity. Additionally, the system is optimized along the months. The results corroborate the fact that the most important variable on cooling tower performance is not the air temperature itself, but its humidity.

Competing effects of groundwater withdrawals and climate change on water availability in semi-arid India

Science.gov (United States)

Sishodia, R. P.; Shukla, S.

2017-12-01

India, a global leader in groundwater use (250 km3/yr), is experiencing groundwater depletion. There has been a 130-fold increase in number of irrigation wells since 1960. Anticipated future increase in groundwater demand is likely to exacerbate the water availability in the semi-arid regions of India. Depending on the direction of change, future climate change may either worsen or enhance the water availability. This study uses an integrated hydrologic modeling approach (MIKE SHE MIKE 11) to compare and combine the effects of future (2040-2069) increased groundwater withdrawals and climate change on surface and groundwater flows and availability for an agricultural watershed in semi-arid south India. Modeling results showed that increased groundwater withdrawals in the future resulted in reduced surface flows (25%) and increased frequency and duration (90 days/yr) of well drying. In contrast, projected future increase in rainfall (7-43%) under the changed climate showed increased groundwater recharge (15-67%) and surface flows (9-155%). Modeling results suggest that the positive effects of climate change may enhance the water availability in this semi-arid region of India. However, in combination with increased withdrawals, climate change was shown to increase the well drying and reduce the water availability especially during dry years. A combination of management options such as flood to drip conversion, energy subsidy reductions and water storage can support increased groundwater irrigated area in the future while mitigating the well drying. A cost-benefit analysis showed that dispersed water storage and flood to drip conversion can be highly cost-effective in this semi-arid region. The study results suggest that the government and management policies need to be focused towards an integrated management of demand and supply to create a sustainable food-water-energy nexus in the region.

Relations between precipitation, groundwater withdrawals, and changes in hydrologic conditions at selected monitoring sites in Volusia County, Florida, 1995--2010

Science.gov (United States)

Murray, Louis C.

2012-01-01

A study to examine the influences of climatic and anthropogenic stressors on groundwater levels, lake stages, and surface-water discharge at selected sites in northern Volusia County, Florida, was conducted in 2009 by the U.S. Geological Survey. Water-level data collected at 20 monitoring sites (17 groundwater and 3 lake sites) in the vicinity of a wetland area were analyzed with multiple linear regression to examine the relative influences of precipitation and groundwater withdrawals on changes in groundwater levels and lake stage. Analyses were conducted across varying periods of record between 1995 and 2010 and included the effects of groundwater withdrawals aggregated from municipal water-supply wells located within 12 miles of the project sites. Surface-water discharge data at the U.S. Geological Survey Tiger Bay canal site were analyzed for changes in flow between 1978 and 2001. As expected, water-level changes in monitoring wells located closer to areas of concentrated groundwater withdrawals were more highly correlated with withdrawals than were water-level changes measured in wells further removed from municipal well fields. Similarly, water-level changes in wells tapping the Upper Floridan aquifer, the source of municipal supply, were more highly correlated with groundwater withdrawals than were water-level changes in wells tapping the shallower surficial aquifer system. Water-level changes predicted by the regression models over precipitation-averaged periods of record were underestimated for observations having large positive monthly changes (generally greater than 1.0 foot). Such observations are associated with high precipitation and were identified as points in the regression analyses that produced large standardized residuals and/or observations of high influence. Thus, regression models produced by multiple linear regression analyses may have better predictive capability in wetland environments when applied to periods of average or below average

CALCULATING WATER CONSUMPTION AND WITHDRAWAL FROM POWER PLANTS GLOBALLYUsing machine learning, remote sensing and power plant data from the Power Watch platform

Science.gov (United States)

Kressig, A.

2017-12-01

BACKGROUND The Greenhouse Gas Protocol (GHGP), Scope 2 Guidance standardizes how companies measure greenhouse gas emissions from purchased or independently generated electricity (called "scope 2 emissions"). Additionally, the interlinkages between industrial or commercial (nonresidential) energy requirements and water demands have been studied extensively, mostly at the national or provincial scale, focused on industries involved in power generation. However there is little guidance available for companies to systematically and effectively quantify water withdrawals and consumption (herein referred to as "water demand") associated with purchased or acquired electricity(what we call "Scope 2 Water"). This lack of guidance on measuring a company's water demand from electricity use is due to a lack of data on average consumption and withdrawal rates of water associated with purchased electricity. OBJECTIVE There is growing demand from companies in the food, beverage, manufacturing, information communication and technology, and other sectors for a methodology to quantify Scope 2 water demands. By understanding Scope 2 water demands, companies could evaluate their exposure to water-related risks associated with purchased or acquired electricity, and quantify the water benefits of changing to less water-intensive sources of electricity and energy generation such as wind and solar. However, there has never been a way of quantifying Scope 2 Water consumption and withdrawals for a company across its international supply chain. Even with interest in understanding exposure to water related risk and measuring water use reductions, there has been no quantitative way of measuring this information. But WRI's Power Watch provides the necessary data to allow for the Scope 2 Water accounting, because it will provide water withdrawal and consumption rates associated with purchased electricity at the power plant level. By calculating the average consumption and withdrawal rates per

Marginal costs of water savings from cooling system retrofits: a case study for Texas power plants

Science.gov (United States)

Loew, Aviva; Jaramillo, Paulina; Zhai, Haibo

2016-10-01

The water demands of power plant cooling systems may strain water supply and make power generation vulnerable to water scarcity. Cooling systems range in their rates of water use, capital investment, and annual costs. Using Texas as a case study, we examined the cost of retrofitting existing coal and natural gas combined-cycle (NGCC) power plants with alternative cooling systems, either wet recirculating towers or air-cooled condensers for dry cooling. We applied a power plant assessment tool to model existing power plants in terms of their key plant attributes and site-specific meteorological conditions and then estimated operation characteristics of retrofitted plants and retrofit costs. We determined the anticipated annual reductions in water withdrawals and the cost-per-gallon of water saved by retrofits in both deterministic and probabilistic forms. The results demonstrate that replacing once-through cooling at coal-fired power plants with wet recirculating towers has the lowest cost per reduced water withdrawals, on average. The average marginal cost of water withdrawal savings for dry-cooling retrofits at coal-fired plants is approximately 0.68 cents per gallon, while the marginal recirculating retrofit cost is 0.008 cents per gallon. For NGCC plants, the average marginal costs of water withdrawal savings for dry-cooling and recirculating towers are 1.78 and 0.037 cents per gallon, respectively.

Simulation of groundwater flow and hydrologic effects of groundwater withdrawals from the Kirkwood-Cohansey aquifer system in the Pinelands of southern New Jersey

Science.gov (United States)

Charles, Emmanuel; Nicholson, Robert S.

2012-01-01

The Kirkwood-Cohansey aquifer system is an important source of present and future water supply in southern New Jersey. Because this unconfined aquifer system also supports sensitive wetland and aquatic habitats within the New Jersey Pinelands (Pinelands), water managers and policy makers need up-to-date information, data, and projections that show the effects of potential increases in groundwater withdrawals on these habitats. Finite-difference groundwater flow models (MODFLOW) were constructed for three drainage basins (McDonalds Branch Basin, 14.3 square kilometers (km2); Morses Mill Stream Basin, 21.63 km2; and Albertson Brook Basin, 52.27 km2) to estimate the effects of potential increases in groundwater withdrawals on water levels and the base-flow portion of streamflow, in wetland and aquatic habitats. Three models were constructed for each drainage basin: a transient model consisting of twenty-four 1-month stress periods (October 2004 through September 2006); a transient model to simulate the 5- to 10-day aquifer tests that were performed as part of the study; and a high-resolution, steady-state model used to assess long-term effects of increased groundwater withdrawals on water levels in wetlands and on base flow. All models were constructed with the same eight-layer structure. The smallest horizontal cell dimensions among the three model areas were 150 meters (m) for the 24-month transient models, 10 m for the steady-state models, and 3 m for the transient aquifer-test models. Boundary flows of particular interest to this study and represented separately are those for wetlands, streams, and evapotranspiration. The final variables calibrated from both transient models were then used in steady-state models to assess the long-term effects of increased groundwater withdrawals on water levels in wetlands and on base flow. Results of aquifer tests conducted in the three study areas illustrate the effects of withdrawals on water levels in wetlands and on base

Developing a methodology for real-time trading of water withdrawal and waste load discharge permits in rivers.

Science.gov (United States)

Soltani, Maryam; Kerachian, Reza

2018-04-15

In this paper, a new methodology is proposed for the real-time trading of water withdrawal and waste load discharge permits in agricultural areas along the rivers. Total Dissolved Solids (TDS) is chosen as an indicator of river water quality and the TDS load that agricultural water users discharge to the river are controlled by storing a part of return flows in some evaporation ponds. Available surface water withdrawal and waste load discharge permits are determined using a non-linear multi-objective optimization model. Total available permits are then fairly reallocated among agricultural water users, proportional to their arable lands. Water users can trade their water withdrawal and waste load discharge permits simultaneously, in a bilateral, step by step framework, which takes advantage of differences in their water use efficiencies and agricultural return flow rates. A trade that would take place at each time step results in either more benefit or less diverted return flow. The Nucleolus cooperative game is used to redistribute the benefits generated through trades in different time steps. The proposed methodology is applied to PayePol region in the Karkheh River catchment, southwest Iran. Predicting that 1922.7 Million Cubic Meters (MCM) of annual flow is available to agricultural lands at the beginning of the cultivation year, the real-time optimization model estimates the total annual benefit to reach 46.07 million US Dollars (USD), which requires 6.31 MCM of return flow to be diverted to the evaporation ponds. Fair reallocation of the permits, changes these values to 35.38 million USD and 13.69 MCM, respectively. Results illustrate the effectiveness of the proposed methodology in the real-time water and waste load allocation and simultaneous trading of permits. Copyright © 2018 Elsevier Ltd. All rights reserved.

75 FR 7526 - Withdrawal of Regulatory Guide

Science.gov (United States)

2010-02-19

...'s Electronic Reading Room at http://www.nrc.gov/reading-rm/doc-collections . Regulatory guides are... NUCLEAR REGULATORY COMMISSION [NRC-2010-0052] Withdrawal of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Withdrawal of Regulatory Guide 1.56, ``Maintenance of Water Purity in Boiling...

75 FR 71559 - Hazardous Waste Management System; Identification and Listing of Hazardous Waste; Withdrawal of...

Science.gov (United States)

2010-11-24

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 261 [EPA-R06-RCRA-2010-0066; SW FRL-9231-4] Hazardous Waste Management System; Identification and Listing of Hazardous Waste; Withdrawal of Direct Final Exclusion AGENCY: Environmental Protection Agency (EPA). ACTION: Withdrawal of direct final exclusion...

Neurobiology of opioid withdrawal: Role of the endothelin system.

Science.gov (United States)

Bhalla, Shaifali; Andurkar, Shridhar V; Gulati, Anil

2016-08-15

Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor antagonists potentiate opioid analgesia and eliminate analgesic tolerance. Mechanistically, G proteins and regulatory proteins such as β-arrestins have shown to play an important role in mediating opioid tolerance, dependence, and withdrawal. Recently, the involvement of central ET mechanisms in opioid withdrawal was investigated. ETA receptor antagonist was shown to block majority of the signs and symptoms associated with opioid withdrawal. This review focuses on ET as one of the potential novel strategies to manage the challenge of opioid withdrawal. An overview of additional players in this process (G proteins and β-arrestin2), and the possible therapeutic implications of these findings are presented. Copyright © 2016 Elsevier Inc. All rights reserved.

Water Use in Georgia by County for 2005; and Water-Use Trends, 1980-2005

Science.gov (United States)

Fanning, Julia L.; Trent, Victoria P.

2009-01-01

Water use for 2005 for each county in Georgia was estimated using data obtained from various Federal and State agencies and local sources. Total consumptive water use also was estimated for each county in Georgia for 2005. Water use is subdivided according to offstream and instream use. Offstream use is defined as water withdrawn or diverted from a ground- or surface-water source and transported to the place of use. Estimates for offstream water use include the categories of public supply, domestic, commercial, industrial, mining, irrigation, livestock, aquaculture, and thermoelectric power. Instream use is that which occurs within a stream channel for such purposes as hydroelectric-power generation, navigation, water-quality improvement, fish propagation, and recreation. The only category of instream use estimated was hydroelectric-power generation. Georgia law (the Georgia Ground-Water Use Act of 1972 and the Georgia Water Supply Act of 1978 [Georgia Department of Natural Resources, 2008a,b]) requires any water user who withdraws more than 100,000 gallons per day on a monthly average to obtain a withdrawal permit from the Georgia Environmental Protection Division. Permit holders generally must report their withdrawals by month. The Georgia Water-Use Program collects the reported information under the withdrawal permit system and the drinking-water permit system and stores the data in the Georgia Water-Use Data System.

Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.

Directory of Open Access Journals (Sweden)

Marina Rubio

Full Text Available Cessation of chronic ethanol consumption can increase the sensitivity of the brain to excitotoxic damages. Cannabinoids have been proposed as neuroprotectants in different models of neuronal injury, but their effect have never been investigated in a context of excitotoxicity after alcohol cessation. Here we examined the effects of the pharmacological activation/inhibition of the endocannabinoid system in an in vitro model of chronic ethanol exposure and withdrawal followed by an excitotoxic challenge. Ethanol withdrawal increased N-methyl-D-aspartate (NMDA-evoked neuronal death, probably by altering the ratio between GluN2A and GluN2B NMDA receptor subunits. The stimulation of the endocannabinoid system with the cannabinoid agonist HU-210 decreased NMDA-induced neuronal death exclusively in ethanol-withdrawn neurons. This neuroprotection could be explained by a decrease in NMDA-stimulated calcium influx after the administration of HU-210, found exclusively in ethanol-withdrawn neurons. By contrast, the inhibition of the cannabinoid system with the CB1 receptor antagonist rimonabant (SR141716 during ethanol withdrawal increased death of ethanol-withdrawn neurons without any modification of NMDA-stimulated calcium influx. Moreover, chronic administration of rimonabant increased NMDA-stimulated toxicity not only in withdrawn neurons, but also in control neurons. In summary, we show for the first time that the stimulation of the endocannabinoid system is protective against the hyperexcitability developed during alcohol withdrawal. By contrast, the blockade of the endocannabinoid system is highly counterproductive during alcohol withdrawal.

Treatment for amphetamine withdrawal.

Science.gov (United States)

Shoptaw, Steven J; Kao, Uyen; Heinzerling, Keith; Ling, Walter

2009-04-15

withdrawal. Amineptine showed reduction in discontinuation rates and improvement in clinical presentation compared to placebo, but had no effect on reducing withdrawal symptoms or craving. In spite of these limited benefits, amineptine is not available for use due to concerns over abuse liability when using the drug. The benefits of mirtazapine as a withdrawal agent are less clear based on findings from two randomised controlled trials: one report showed improvements in amphetamine withdrawal symptoms over placebo; a second report showed no differences in withdrawal symptoms compared to placebo. Further potential treatment studies should examine medications that increase central nervous system activity involving dopamine, norepinephrine and/or serotonin neurotransmitters, including mirtazapine.

Metabolic modelling to support long term strategic decisions on water supply systems

Science.gov (United States)

Ciriello, Valentina; Felisa, Giada; Lauriola, Ilaria; Pomanti, Flavio; Di Federico, Vittorio

2017-04-01

Water resources are essential for the economic development and sustenance of anthropic activities belonging to the civil, agricultural and industrial sectors. Nevertheless, availability of water resources is not uniformly distributed in space and time. Moreover, the increasing water demand, mainly due to population growth and expansion of agricultural crops, may cause increasing water stress conditions, if combined with the effects of climate change. Under these circumstances, it is necessary to improve the resilience of water supply systems both in terms of infrastructures and environmental compliance. Metabolic modelling approaches represent a flexible tool able to provide support to decision making in the long term, based on sustainability criteria. These approaches mimic the water supply network through a set of material and energy fluxes that interact and influence each other. By analyzing these fluxes, a suite of key performance indicators is evaluated in order to identify which kind of interventions may be applied to increase the sustainability of the system. Here, we adopt these concepts to analyze the water supply network of Reggio-Emilia (Italy) which is supported by water withdrawals from both surface water and groundwater bodies. We analyze different scenarios, including possible reduction of water withdrawals from one of the different sources as a consequence of a decrease in water availability under present and future scenarios. On these basis, we identify preventive strategies for a dynamic management of the water supply system.

Simulated effects of potential withdrawals from wells near Yucca Mountain, Nevada

International Nuclear Information System (INIS)

Tucce, Patrick; Faunt, Claudia C.

1999-01-01

The effects of potential future withdrawals from wells J-12, J-13, and UE-25c number 3 on the ground-water flow system in the area surrounding Yucca Mountain, Nevada, were simulated by using an existing (1997) three-dimensional regional ground-water flow model. The 1997 regional model was modified only to include changes at the pumped wells. Two steady-state simulations (baseline and predictive) were conducted to estimate changes in water level and changes in ground-water outflow from Jackass Flats, where the pumped wells are located, south to the Amargosa Desert

Recalibration of a ground-water flow model of the Mississippi River Valley alluvial aquifer in Southeastern Arkansas, 1918, with simulations of hydraulic heads caused by projected ground-water withdrawals through 2049

Science.gov (United States)

Stanton, Gregory P.; Clark, Brian R.

2003-01-01

The Mississippi River Valley alluvial aquifer, encompassing parts of Arkansas, Kentucky, Louisiana, Mississippi, Missouri, and Tennessee supplies an average of 5 billion gallons of water per day. However, withdrawals from the aquifer in recent years have caused considerable drawdown in the hydraulic heads in southeastern Arkansas and other areas. The effects of current ground-water withdrawals and potential future withdrawals on water availability are major concerns of water managers and users as well as the general public. A full understanding of the behavior of the aquifer under various water-use scenarios is critical for the development of viable water-management and alternative source plans. To address these concerns, the U.S. Geological Survey, in cooperation with the U.S. Army Corps of Engineers, Vicksburg District, and the Arkansas Soil and Water Conservation Commission developed and calibrated a ground-water flow model for the Mississippi River valley alluvial aquifer in southeastern Arkansas to simulate hydraulic heads caused by projected ground-water withdrawals. A previously published ground-water flow model for the alluvial aquifer in southeastern Arkansas was updated and recalibrated to reflect more current pumping stresses with additional stress periods added to bring the model forward from 1982 to 1998. The updated model was developed and calibrated with MODFLOW-2000 finite difference numerical modeling and parameter estimation software. The model was calibrated using hydraulic-head data collected during 1972 and 1982 and hydraulic-head measurements made during spring (February to April) of 1992 and 1998. The residuals for 1992 and 1998 have a mean absolute value of 4.74 and 5.45 feet, respectively, and a root mean square error of 5.9 and 6.72 feet, respectively. The effects of projected ground-water withdrawals were simulated through 2049 in three predictive scenarios by adding five additional stress periods of 10 years each. In the three scenarios

The effects of withdrawals and drought on groundwater availability in the Northern Guam Lens Aquifer, Guam

Science.gov (United States)

Gingerich, Stephen B.

2013-01-01

Owing to population growth, freshwater demand on Guam has increased in the past and will likely increase in the future. During the early 1970s to 2010, groundwater withdrawals from the limestone Northern Guam Lens Aquifer, the main source of freshwater on the island, tripled from about 15 to 45 million gallons per day. Because of proposed military relocation to Guam and expected population growth, freshwater demand on Guam is projected to increase further. The expected increased demand for groundwater has led to concern over the long-term sustainability of withdrawals from existing and proposed wells. A three-dimensional numerical groundwater flow and transport model was developed to simulate the effects of hypothetical withdrawal and recharge scenarios on water levels and on the transition zone between freshwater and saltwater. The model was constructed by using average recharge during 1961–2005 and withdrawals from 2010. Hydraulic properties used to construct the model were initially based on published estimates but ultimately were adjusted to obtain better agreement between simulated and measured water levels and salinity profiles in the modeled area. Two hypothetical groundwater withdrawal scenarios were simulated: no withdrawal to simulate predevelopment conditions and withdrawal at 2010 rates under a 5-year drought. Simulation results indicate that prior to pumping; the fresh-water lens was 10 to 50 feet thicker in the Yigo-Tumon basin and more than 50 feet thicker in the Hagåtña basin. Results also indicate that continuing the 2010 withdrawal distribution during a 5-year drought would result in decreased water levels, a thinner freshwater lens, and increased salinity of water pumped from wells. The available water with an acceptable salinity (chloride concentration less than 200 milligrams per liter) would decrease from about 34 million gallons per day to 11.5 million gallons per day after 5 years but recover to pre-drought levels 5 years after the

Man-made organic compounds in source water of nine community water systems that withdraw from streams, 2002-05

Science.gov (United States)

Kingsbury, James A.; Delzer, Gregory C.; Hamilton, Pixie A.

2008-01-01

Initial findings from a national study by the National Water-Quality Assessment (NAWQA) Program of the U.S. Geological Survey (USGS) characterize the occurrence of about 250 anthropogenic organic compounds in source water (defined as water collected at a surface-water intake prior to water treatment) at nine community water systems in nine States in the Nation. The organic compounds analyzed in this study are primarily man-made and include pesticides, solvents, gasoline hydrocarbons, personal-care and domestic-use products, disinfection by-products, and manufacturing additives. The study also describes and compares the occurrence of selected compounds detected in source water with their occurrence in finished water, which is defined as water that has passed through treatment processes but prior to distribution. This fact sheet summarizes major findings and implications of the study and serves as a companion product to two USGS reports that present more detailed and technical information for the nine systems studied during 2002-05 (Carter and others, 2007; Kingsbury and others, 2008).

Operational Water Withdrawal and Consumption Factors for Electricity Generation Technology in China—A Literature Review

Directory of Open Access Journals (Sweden)

Jinjing Gao

2018-04-01

Full Text Available As two indispensable resources for human development, energy and water are closely related. China, as the world’s largest consumer of electricity, is also experiencing very serious water shortages. Understanding the water consumption intensity in various types of electric power production technologies according to China’s national conditions is a prerequisite for understanding the potential impact of electrical power production on water resources. Therefore, following the steps of a meta-analysis, this paper provides a literature review on operational water withdrawal and consumption factors for electricity generation technology in China. We observed that 50% of water consumption for electricity generation was for coal power, whereas there was no research on the water consumption intensity of natural gas power generation, and a shortage of studies on water intake during electrical power production. The average water consumption intensity of hydropower is the largest. The results indicate that compared with other fuel types, hydropower is not a sustainable energy with respect to water conservation, and the study of hydropower applications should be improved in China.

Effect of intensive epilimnetic withdrawal on phytoplankton community in a (subtropical deep reservoir

Directory of Open Access Journals (Sweden)

Man Zhang

2013-10-01

Full Text Available Withdrawal is an important process in reservoir hydrodynamics, removing phytoplankton with flushed water. Zooplankton，the grazers of phytoplankton, having longer generation times, are even more susceptible than phytoplankton to flushing loss. Therefore phytoplankton are affected not only by abiotic conditions linked to hydrodynamics but also by zooplankton due to weakened grazing pressure. During the Asian Games (November 12-27, 2010 in Guangzhou, China, two intensive epilimnetic withdrawals were conducted in Liuxihe, a deep canyon-shaped reservoir. To examine the influence of the intensive epilimnetic withdrawals on the phytoplankton community, a seven-week field observation and a hydrodynamic simulation were carried out. The observation was divided in two stages: stage 1 represented partial surface vertical mixing period, and stage 2 represented intensive epilimnetic withdrawal period. It was found that phytoplankton abundance and biomass declined with water temperature and partial surface vertical mixing in stage 1. However, the intensive epilimnetic withdrawal reversed this decreasing trend and increased phytoplankton biomass and abundance in stage 2. Phytoplankton showed a higher rate of composition change in stage 2. A numerical model (DYRESM-CAEDYM simulated scenarios with and without epilimnetic withdrawal to test their effects on abiotic factors (water temperature, suspended sediment and soluble reactive phosphorus for phytoplankton. The results showed no obvious difference in the abiotic factors between the two scenarios during stage 2. We therefore suggested that the abiotic factors in the water column were probably driven by a seasonal pattern, not by epilimnetic withdrawal. It is likely that the intensive epilimnetic withdrawal could remove large crustaceans. The reduced grazing pressure probably explained the increase of phytoplankton biomass and abundance after the withdrawal. Thus, we suggest that reservoir operation should pay

National water summary 1987: Hydrologic events and water supply and use

Science.gov (United States)

Carr, Jerry E.; Chase, Edith B.; Paulson, Richard W.; Moody, David W.

1990-01-01

Water use in the United States, as measured by freshwater withdrawals in 1985, averaged 338,000 Mgal/d (million gallons per day), which is enough water to cover the 48 conterminous States to a depth of about 2.4 inches. Only 92,300 Mgal/d, or 27.3 percent of the water withdrawn, was consumptive use and thus lost to immediate further use; the remainder of the withdrawals (72.7 percent) was return flow available for reuse a number of times as the water flowed to the sea. The 1985 freshwater withdrawals were much less than the average 30 inches of precipitation that falls on the conterminous States each year; consumptive use accounted for only 7 percent of the estimated annual runoff of 1,230,000 Mgal/d. Nonetheless, as the State summaries on water supply and use clearly show, water is not always available when and where it is needed. Balancing water demands with available water supplies constitutes one of the major resource allocation issues that will face the United States in the coming decade.Of the 1985 freshwater withdrawals, 78.3 percent (265,000 Mgal/d) came from surface-water sources (streams and lakes), and 21.7 percent (73,300 Mgal/d) came from ground water. Surface water provided drinking water for about 47 percent of the Nation's total population. It was the source of 59.9 percent of the Nation's public-supply systems. For self-supplied withdrawals, surface water accounted for 1.6 percent of the domestic and commercial uses; 64.0 percent of the industrial and mining use; 99.4 percent of the thermoelectric generation withdrawals, mainly for cooling water; and 65.6 percent of the agricultural withdrawals. Eight States accounted for 43 percent of the surface-water use; California, Colorado, and Idaho used surface water primarily for irrigation, and Dlinois, Michigan, Ohio, Pennsylvania, and Texas used surface-water primarily for cooling condensers or reactors in thermoelectric plants.Ground water provided drinking water for 53 percent of the Nation's total

Model simulation of the Manasquan water-supply system in Monmouth County, New Jersey

Science.gov (United States)

Chang, Ming; Tasker, Gary D.; Nieswand, Steven

2001-01-01

Model simulation of the Manasquan Water Supply System in Monmouth County, New Jersey, was completed using historic hydrologic data to evaluate the effects of operational and withdrawal alternatives on the Manasquan reservoir and pumping system. Changes in the system operations can be simulated with the model using precipitation forecasts. The Manasquan Reservoir system model operates by using daily streamflow values, which were reconstructed from historical U.S. Geological Survey streamflow-gaging station records. The model is able to run in two modes--General Risk analysis Model (GRAM) and Position Analysis Model (POSA). The GRAM simulation procedure uses reconstructed historical streamflow records to provide probability estimates of certain events, such as reservoir storage levels declining below a specific level, when given an assumed set of operating rules and withdrawal rates. POSA can be used to forecast the likelihood of specified outcomes, such as streamflows falling below statutory passing flows, associated with a specific working plan for the water-supply system over a period of months. The user can manipulate the model and generate graphs and tables of streamflows and storage, for example. This model can be used as a management tool to facilitate the development of drought warning and drought emergency rule curves and safe yield values for the water-supply system.

Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice.

Science.gov (United States)

Hwa, Lara S; Nathanson, Anna J; Shimamoto, Akiko; Tayeh, Jillian K; Wilens, Allison R; Holly, Elizabeth N; Newman, Emily L; DeBold, Joseph F; Miczek, Klaus A

2015-08-01

Disrupted social behavior, including occasional aggressive outbursts, is characteristic of withdrawal from long-term alcohol (EtOH) use. Heavy EtOH use and exaggerated responses during withdrawal may be treated using glutamatergic N-methyl-D-aspartate receptor (NMDAR) antagonists. The current experiments explore aggression and medial prefrontal cortex (mPFC) glutamate as consequences of withdrawal from intermittent access to EtOH and changes in aggression and mPFC glutamate caused by NMDAR antagonists memantine and ketamine. Swiss male mice underwent withdrawal following 1-8 weeks of intermittent access to 20 % EtOH. Aggressive and nonaggressive behaviors with a conspecific were measured 6-8 h into EtOH withdrawal after memantine or ketamine (0-30 mg/kg, i.p.) administration. In separate mice, extracellular mPFC glutamate after memantine was measured during withdrawal using in vivo microdialysis. At 6-8 h withdrawal from EtOH, mice exhibited more convulsions and aggression and decreased social contact compared to age-matched water controls. Memantine, but not ketamine, increased withdrawal aggression at the 5-mg/kg dose in mice with a history of 8 weeks of EtOH but not 1 or 4 weeks of EtOH or in water drinkers. Tonic mPFC glutamate was higher during withdrawal after 8 weeks of EtOH compared to 1 week of EtOH or 8 weeks of water. Five milligrams per kilogram of memantine increased glutamate in 8-week EtOH mice, but also in 1-week EtOH and water drinkers. These studies reveal aggressive behavior as a novel symptom of EtOH withdrawal in outbred mice and confirm a role of NMDARs during withdrawal aggression and for disrupted social behavior.

Ketogenic Diet suppresses Alcohol Withdrawal Syndrome in Rats

DEFF Research Database (Denmark)

Dencker, Ditte; Molander, Anna; Thomsen, Morgane

2018-01-01

, we investigated the potential therapeutic benefit of a ketogenic diet in managing alcohol withdrawal symptoms during detoxification. METHODS: Male Sprague Dawley rats fed either ketogenic or regular diets were administered ethanol or water orally, twice daily for 6 days while the diet conditions were...... maintained. Abstinence symptoms were rated 6, 24, 48, and 72 hours after the last alcohol administration. RESULTS: Maintenance on a ketogenic diet caused a significant decrease in the alcohol withdrawal symptoms 'rigidity' and 'irritability'. CONCLUSION: Our preclinical pilot study suggests that a ketogenic...... diet may be a novel approach for treating alcohol withdrawal symptoms in humans. This article is protected by copyright. All rights reserved....

Complex plastic changes in the neuropeptide Y system during ethanol intoxication and withdrawal in the rat brain

DEFF Research Database (Denmark)

Olling, J D; Ulrichsen, J; Christensen, D Z

2009-01-01

and NPY-stimulated [(35)S]GTPgammaS functional binding. Rats received intragastric ethanol repeatedly for 4 days, and the NPY system was studied in the hippocampal dentate gyrus (DG), CA3, CA1, and piriform cortex (PirCx) and neocortex (NeoCx) during intoxication, peak withdrawal (16 hr), late withdrawal...

Performance Optimization of the Water Cooling System for Resonance Frequency Control of the PEFP DTL

International Nuclear Information System (INIS)

Kim, K. Y.; Kim, H. K.; Kim, H. S.; Yoon, J. C.; Sohn, Y. K.; Kweon, S. J.; Park, J.; Kim, K. S.

2010-03-01

The objective of in this research project is prototype cooling water skid of separated closed loop in order to supply and withdraw low conductivity deionized water in drift tube of drift tube linac as core components of proton accelerates. This report is dealt with design specification of J-PARC 400 MeV Linac cooling water system, PEFP DTL cooling system, specification of RCCS21-24, RCCS101 with pump, loss coefficient for DTL2 modeling, pressure drop with flow rate of heat exchanger.

Simulation of ground-water flow and evaluation of water-management alternatives in the upper Charles River basin, eastern Massachusetts

Science.gov (United States)

DeSimone, Leslie A.; Walter, Donald A.; Eggleston, John R.; Nimiroski, Mark T.

2002-01-01

Ground water is the primary source of drinking water for towns in the upper Charles River Basin, an area of 105 square miles in eastern Massachusetts that is undergoing rapid growth. The stratified-glacial aquifers in the basin are high yield, but also are thin, discontinuous, and in close hydraulic connection with streams, ponds, and wetlands. Water withdrawals averaged 10.1 million gallons per day in 1989?98 and are likely to increase in response to rapid growth. These withdrawals deplete streamflow and lower pond levels. A study was conducted to develop tools for evaluating water-management alternatives at the regional scale in the basin. Geologic and hydrologic data were compiled and collected to characterize the ground- and surface-water systems. Numerical flow modeling techniques were applied to evaluate the effects of increased withdrawals and altered recharge on ground-water levels, pond levels, and stream base flow. Simulation-optimization methods also were applied to test their efficacy for management of multiple water-supply and water-resource needs. Steady-state and transient ground-water-flow models were developed using the numerical modeling code MODFLOW-2000. The models were calibrated to 1989?98 average annual conditions of water withdrawals, water levels, and stream base flow. Model recharge rates were varied spatially, by land use, surficial geology, and septic-tank return flow. Recharge was changed during model calibration by means of parameter-estimation techniques to better match the estimated average annual base flow; area-weighted rates averaged 22.5 inches per year for the basin. Water withdrawals accounted for about 7 percent of total simulated flows through the stream-aquifer system and were about equal in magnitude to model-calculated rates of ground-water evapotranspiration from wetlands and ponds in aquifer areas. Water withdrawals as percentages of total flow varied spatially and temporally within an average year; maximum values were

Trade Openness and Domestic Water Use

Science.gov (United States)

Dang, Qian; Konar, Megan

2018-01-01

We contribute to the debate over globalization and the environment by asking, what is the impact of trade on national water use? To address this question, we employ econometric methods to quantify the causal relationship between trade openness and water use. Specifically, we use the instrumental variables methodology to evaluate the impact of trade openness on domestic water withdrawals in agriculture and industry. We find that trade openness does not have a significant impact on total or industrial water withdrawals. However, we show that one percentage point increase in trade openness leads to a 5.21% decrease in agricultural water withdrawals. We find that trade openness reduces water use in agriculture primarily through the intensive margin effect, by leading farmers to produce more with less water, such as through the adoption of technology. We do not find evidence for extensive margin or crop mix impacts on agricultural water withdrawals. Significantly, these results demonstrate that trade openness leads to less water use in agriculture. This finding has broad scientific and policy relevance as we endeavor to untangle causal relationships in the complex global food system and develop policies to achieve water and food security.

Time-dependent negative reinforcement of ethanol intake by alleviation of acute withdrawal.

Science.gov (United States)

Cunningham, Christopher L; Fidler, Tara L; Murphy, Kevin V; Mulgrew, Jennifer A; Smitasin, Phoebe J

2013-02-01

Drinking to alleviate the symptoms of acute withdrawal is included in diagnostic criteria for alcoholism, but the contribution of acute withdrawal relief to high alcohol intake has been difficult to model in animals. Ethanol dependence was induced by passive intragastric ethanol infusions in C57BL/6J (B6) and DBA/2J (D2) mice; nondependent control animals received water infusions. Mice were then allowed to self-administer ethanol or water intragastrically. The time course of acute withdrawal was similar to that produced by chronic ethanol vapor exposure in mice, reaching a peak at 7 to 9 hours and returning to baseline within 24 hours; withdrawal severity was greater in D2 than in B6 mice (experiment 1). Postwithdrawal delays in initial ethanol access (1, 3, or 5 days) reduced the enhancement in later ethanol intake normally seen in D2 (but not B6) mice allowed to self-infuse ethanol during acute withdrawal (experiment 2). The postwithdrawal enhancement of ethanol intake persisted over a 5-day abstinence period in D2 mice (experiment 3). D2 mice allowed to drink ethanol during acute withdrawal drank more ethanol and self-infused more ethanol than nondependent mice (experiment 4). Alcohol access during acute withdrawal increased later alcohol intake in a time-dependent manner, an effect that may be related to a genetic difference in sensitivity to acute withdrawal. This promising model of negative reinforcement encourages additional research on the mechanisms underlying acute withdrawal relief and its role in determining risk for alcoholism. Copyright © 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Regional water coefficients for U.S. industrial sectors

OpenAIRE

Riccardo Boero; Donatella Pasqualini

2017-01-01

Designing policies for water systems management requires the capability to assess the economic impacts of water availability and to effectively couple water withdrawals by human activities with natural hydrologic dynamics. At the core of any scientific approach to these issues there is the estimation of water withdrawals by industrial sectors in the form of water coefficients, which are measurements of the quantity of water withdrawn per dollar of GDP or output. In this work we focus on the c...

18 CFR 801.3 - Allocations, diversions, withdrawals and release.

Science.gov (United States)

2010-04-01

... wherein the demands upon supply made by water users have developed or threaten to develop to such a degree..., or withdrawals of water be based on the common law principles of riparian rights which entitles... actual and immediate shortage of available and usable water supply, determine and delineate the area of...

Hungry Horse mitigation: Aquatic modeling of the selective withdrawal system -- Hungry Horse Dam, Montana

International Nuclear Information System (INIS)

Marotz, B.L.; Althen, C.; Gustafson, D.

1994-04-01

Hungry Horse Dam presently releases frigid water from the bottom of the reservoir all year long. Cold water effects insect production and fish growth downstream. Rapid temperature changes of up to 8.3 C (14 F) have been measured in the Flathead River downstream of the South Fork confluence, controlled by dam discharges. Thermal effects from Hungry Horse Dam are detectable for over 64 Km downstream to Flathead Lake. The installation of a selective withdrawal structure on each of the dam's discharge penstocks was determined to be the most cost-effective means to provide constant, permanent temperature control without impacting power production and flexibility in dam operation. The thermal model presented herein revealed that fish growth potential in the river would increase two to five times through selective withdrawal, temperature control. Temperature control is possible over the entire range of turbine discharge capacity, with very little effect on power production. Findings indicate that angling would improve through higher catch rates and larger fish. Temperature control will solve the most serious impact to river health. However, flow fluctuations will continue to effect insect production and usable fishery habitat in the Flathead River. A natural thermal regime combined with moderated flow fluctuation would further enhance riverine food production, trout growth and recreation potential

Mitigation options for chemicals of emerging concern in surface waters operationalising solutions-focused risk assessment

NARCIS (Netherlands)

Van Wezel, Annemarie P.; Ter Laak, Thomas L.; Fischer, Astrid; Bäuerlein, Patrick S.; Munthe, John; Posthuma, Leo

2017-01-01

The water system provides many services to society; industries, municipalities and agriculture all withdraw, use and return water and demand a water quality fit for the intended purposes. Both global production of chemicals and global water withdrawal grow faster than human population. This implies

[An examination of the determinants of social withdrawal and affinity for social withdrawal].

Science.gov (United States)

Watanabe, Asami; Matsui, Yutaka; Takatsuka, Yusuke

2010-12-01

This study examined the determinants of social withdrawal using data from a survey by the Tokyo Metropolitan Government Office for Youth Affairs and Public Safety (2008). In addition, this study identified young people who showed an affinity for social withdrawal although they were not in a state of withdrawal, and examined the determinants of an affinity for social withdrawal. The results of stepwise discriminant analysis showed that factors such as social phobia, depression, violence, and emotional bonds with family differentiated between the general youth group and the social withdrawal group and the "affinity group". Social phobia, violence, and refusal to be interfered in self-decision making differentiated between the social withdrawal group and the "affinity group". This study shows that an "affinity group" should be cared as well as an actual withdrawal group.

User's Manual for the New England Water-Use Data System (NEWUDS)

Science.gov (United States)

Horn, Marilee A.

2003-01-01

Water is used in a variety of ways that need to be understood for effective management of water resources. Water-use activities need to be categorized and included in a database management system to understand current water uses and to provide information to water-resource management policy decisionmakers. The New England Water-Use Data System (NEWUDS) is a complex database developed to store water-use information that allows water to be tracked from a point of water-use activity (called a 'Site'), such as withdrawal from a resource (reservoir or aquifer), to a second Site, such as distribution to a user (business or irrigator). NEWUDS conceptual model consists of 10 core entities: system, owner, address, location, site, data source, resource, conveyance, transaction/rate, and alias, with tables available to store user-defined details. Three components--site (with both a From Site and a To Site), a conveyance that connects them, and a transaction/rate associated with the movement of water over a specific time interval form the core of the basic NEWUDS network model. The most important step in correctly translating real-world water-use activities into a storable format in NEWUDS depends on choosing the appropriate sites and linking them correctly in a network to model the flow of water from the initial From Site to the final To Site. Ten water-use networks representing real-world activities are described--three withdrawal networks, three return networks, two user networks, two complex community-system networks. Ten case studies of water use, one for each network, also are included in this manual to illustrate how to compile, store, and retrieve the appropriate data. The sequence of data entry into tables is critical because there are many foreign keys. The recommended core entity sequence is (1) system, (2) owner, (3) address, (4) location, (5) site, (6) data source, (7) resource, (8) conveyance, (9) transaction, and (10) rate; with (11) alias and (12) user

A Mock UF6 Feed and Withdrawal System for Testing Safeguards Monitoring Systems and Strategies Intended for Nuclear Fuel Enrichment and Processing Plants

International Nuclear Information System (INIS)

Krichinsky, Alan M.; Bates, Bruce E.; Chesser, Joel B.; Koo, Sinsze; Whitaker, J. Michael

2009-01-01

This report describes an engineering-scale, mock UF6 feed and withdrawal (F and W) system, its operation, and its intended uses. This system has been assembled to provide a test bed for evaluating and demonstrating new methodologies that can be used in remote, unattended, continuous monitoring of nuclear material process operations. These measures are being investigated to provide independent inspectors improved assurance that operations are being conducted within declared parameters, and to increase the overall effectiveness of safeguarding nuclear material. Testing applicable technologies on a mock F and W system, which uses water as a surrogate for UF6, enables thorough and cost-effective investigation of hardware, software, and operational strategies before their direct installation in an industrial nuclear material processing environment. Electronic scales used for continuous load-cell monitoring also are described as part of the basic mock F and W system description. Continuous monitoring components on the mock F and W system are linked to a data aggregation computer by a local network, which also is depicted. Data collection and storage systems are described only briefly in this report. The mock UF 6 F and W system is economical to operate. It uses a simple process involving only a surge tank between feed tanks and product and withdrawal (or waste) tanks. The system uses water as the transfer fluid, thereby avoiding the use of hazardous UF 6 . The system is not tethered to an operating industrial process involving nuclear materials, thereby allowing scenarios (e.g., material diversion) that cannot be conducted otherwise. These features facilitate conducting experiments that yield meaningful results with a minimum of expenditure and quick turnaround time. Technologies demonstrated on the engineering-scale system lead to field trials (described briefly in this report) for determining implementation issues and performance of the monitoring technologies under

Opiate and opioid withdrawal

Science.gov (United States)

... opiate withdrawal; Oxycontin - opiate withdrawal; Hydrocodone - opiate withdrawal; Detox - opiates; Detoxification - opiates ... facilities set up to help people with detoxification (detox). In a regular hospital, if symptoms are severe. ...

Simulation of groundwater flow to assess future withdrawals associated with Base Realignment and Closure (BRAC) at Fort George G. Meade, Maryland

Science.gov (United States)

Raffensperger, Jeff P.; Fleming, Brandon J.; Banks, William S.L.; Horn, Marilee A.; Nardi, Mark R.; Andreasen, David C.

2010-01-01

Increased groundwater withdrawals from confined aquifers in the Maryland Coastal Plain to supply anticipated growth at Fort George G. Meade (Fort Meade) and surrounding areas resulting from the Department of Defense Base Realignment and Closure Program may have adverse effects in the outcrop or near-outcrop areas. Specifically, increased pumping from the Potomac Group aquifers (principally the Patuxent aquifer) could potentially reduce base flow in small streams below rates necessary for healthy biological functioning. Additionally, water levels may be lowered near, or possibly below, the top of the aquifer within the confined-unconfined transition zone near the outcrop area. A three-dimensional groundwater flow model was created to incorporate and analyze data on water withdrawals, streamflow, and hydraulic head in the region. The model is based on an earlier model developed to assess the effects of future withdrawals from well fields in Anne Arundel County, Maryland and surrounding areas, and includes some of the same features, including model extent, boundary conditions, and vertical discretization (layering). The resolution (horizontal grid discretization) of the earlier model limited its ability to simulate the effects of withdrawals on the outcrop and near-outcrop areas. The model developed for this study included a block-shaped higher-resolution local grid, referred to as the child model, centered on Fort Meade, which was coupled to the coarser-grid parent model using the shared node Local Grid Refinement capability of MODFLOW-LGR. A more detailed stream network was incorporated into the child model. In addition, for part of the transient simulation period, stress periods were reduced in length from 1 year to 3 months, to allow for simulation of the effects of seasonally varying withdrawals and recharge on the groundwater-flow system and simulated streamflow. This required revision of the database on withdrawals and estimation of seasonal variations in

Water Use in Oklahoma 1950-2005

Science.gov (United States)

Tortorelli, Robert L.

2009-01-01

Comprehensive planning for water resources development and use in Oklahoma requires a historical perspective on water resources. The U.S. Geological Survey, in cooperation with the Oklahoma Water Resources Board, summarized the 1950-2005 water-use information for Oklahoma. This report presents 1950-2005 estimates of freshwater withdrawal for water use in Oklahoma by source and category in 5-year intervals. Withdrawal source was either surface water or groundwater. Withdrawal categories include: public supply, irrigation, livestock and aquaculture, thermoelectric-power generation (cooling water), domestic and commercial, and industrial and mining. Withdrawal data were aggregated and tabulated by county, major river basin, and principal aquifer. The purpose of this report is to summarize water-use data in Oklahoma through: (1) presentation of detailed information on freshwater withdrawals by source, county, major river basin, and principal aquifer for 2005; (2) comparison of water use by source, category, major river basin, and principal aquifer at 5-year intervals from 1990-2005; and (3) comparison of water use on a statewide basis by source and category at 5-year intervals from 1950-2005. Total withdrawals from surface-water and groundwater sources during 2005 were 1,559 million gallons per day-989 million gallons a day or 63 percent from surface-water sources and 570 million gallons per day or 37 percent from groundwater sources. The three largest water use categories were: public supply, 646 million gallons per day or 41 percent of total withdrawals; irrigation, 495 million gallons per day or 32 percent of total withdrawals; and livestock and aquaculture, 181 million gallons per day or 12 percent of total withdrawals. All other categories were 237 million gallons per day or 15 percent of total withdrawals. The influence of public supply on the total withdrawals can be seen in the eastern two-thirds of Oklahoma; whereas, the influence of irrigation on total

Estimated use of water in the United States in 2015

Science.gov (United States)

Dieter, Cheryl A.; Maupin, Molly A.; Caldwell, Rodney R.; Harris, Melissa A.; Ivahnenko, Tamara I.; Lovelace, John K.; Barber, Nancy L.; Linsey, Kristin S.

2018-06-19

thermoelectric power accounted for 97 percent of total saline surface-water withdrawals for all uses. Thermoelectric-power withdrawals accounted for 41 percent of total withdrawals for all uses, and freshwater withdrawals for thermoelectric power accounted for 34 percent of the total freshwater withdrawals for all uses. Total consumptive use for thermoelectric power was 4.31 Bgal/d in 2015 or 3 percent of the total thermoelectric-power withdrawals.Irrigation withdrawals were 118 Bgal/d in 2015, an increase of 2 percent from 2010 (116 Bgal/d), but were approximately equal to withdrawals estimated in the 1960s. Irrigation withdrawals, all freshwater, accounted for 42 percent of total freshwater withdrawals for all uses and 64 percent of total freshwater withdrawals for all uses excluding thermoelectric power. Surface-water withdrawals (60.9 Bgal/d) accounted for 52 percent of the total irrigation withdrawals, or about 8 percent less than in 2010. Ground­water withdrawals for irrigation were 57.2 Bgal/d in 2015, about 16 percent more than in 2010. About 63,500 thousand acres (or 63.5 million acres) were irrigated in 2015, an increase from 2010 of about 1,130 thousand acres (2 percent). The number of acres irrigated using sprinkler and microirrigation systems accounted for 63 percent of the total irrigated lands in 2015. Total consumptive use for irrigation was 73.2 Bgal/d in 2015 or 62 percent of the total use (withdrawals and reclaimed wastewater).Public-supply withdrawals in 2015 were 39.0 Bgal/d, or 7 percent less than in 2010, continuing the declines observed from 2005 to 2010. Total population in the United States increased from 312.6 million people in 2010 to 325.0 million people in 2015, an increase of 4 percent. Public-supply withdrawals accounted for 14 percent of the total freshwater withdrawals for all uses and 21 percent of freshwater with­drawals for all uses, excluding thermoelectric power. The number of people that received potable water from public

Optimization of regional water - power systems under cooling constraints and climate change

DEFF Research Database (Denmark)

Payet-burin, Raphaël; Bertoni, Federica; Davidsen, Claus

2018-01-01

Thermo-electric generation represents 70% of Europe's electricity production and 43% of water withdrawals, and is therefore a key element of the water-energy nexus. In 2003, 2006 and 2009, several thermal power plants had to be switched off in Europe because of heat waves, showing the need...... to assess the impact of climate change on cooling constraints of thermal power plants. An integrated water-power model of the Iberian Peninsula was developed in this study. It includes a physical hydrologic representation, spatially and temporally resolved water demands, management of water infrastructure...... and a simple power system model. The system was evaluated under present and future climatic conditions using different climate change scenarios. The cost of cooling constraints is found to increase by 220–640 million €/year, for the period 2046–2065 depending on the climate change scenario. Average available...

Integration of Water Resource Models with Fayetteville Shale Decision Support and Information System

Energy Technology Data Exchange (ETDEWEB)

Cothren, Jackson; Thoma, Greg; DiLuzio, Mauro; Limp, Fred

2013-06-30

Significant issues can arise with the timing, location, and volume of surface water withdrawals associated with hydraulic fracturing of gas shale reservoirs as impacted watersheds may be sensitive, especially in drought years, during low flow periods, or during periods of the year when activities such as irrigation place additional demands on the surface supply of water. Significant energy production and associated water withdrawals may have a cumulative impact to watersheds over the short-term. Hence, hydraulic fracturing based on water withdrawal could potentially create shifts in the timing and magnitude of low or high flow events or change the magnitude of river flow at daily, monthly, seasonal, or yearly time scales. These changes in flow regimes can result in dramatically altered river systems. Currently little is known about the impact of fracturing on stream flow behavior. Within this context the objective of this study is to assess the impact of the hydraulic fracturing on the water balance of the Fayetteville Shale play area and examine the potential impacts of hydraulic fracturing on river flow regime at subbasin scale. This project addressed that need with four unique but integrated research and development efforts: 1) Evaluate the predictive reliability of the Soil and Water Assessment Tool (SWAT) model based at a variety of scales (Task/Section 3.5). The Soil and Water Assessment Tool (SWAT) model was used to simulate the across-scale water balance and the respective impact of hydraulic fracturing. A second hypothetical scenario was designed to assess the current and future impacts of water withdrawals for hydraulic fracturing on the flow regime and on the environmental flow components (EFCs) of the river. The shifting of these components, which present critical elements to water supply and water quality, could influence the ecological dynamics of river systems. For this purpose, we combined the use of SWAT model and Richter et al.’s (1996

Selegiline prevents long-term changes in dopamine efflux and stress immobility during the second and third weeks of abstinence following opiate withdrawal.

Science.gov (United States)

Grasing, K; Ghosh, S

1998-08-01

Selegiline is an irreversible inhibitor of monoamine oxidase B with trophic and neuroprotective effects. Because of evidence for decreased dopaminergic function during the withdrawal syndromes associated with opiates and other medications with potential for abuse, we investigated effects of treatment with selegiline on in vitro measures of dopamine efflux following opiate withdrawal. Treatment with 2.0 mg/kg/day of selegiline did not modify the severity of opiate withdrawal, as assessed by weight loss over the first 3 days of abstinence. Opiate withdrawal increased immobility in response to a forced warm water swim test performed during the second and third weeks of abstinence following the onset of withdrawal. Brain slices obtained from the nucleus accumbens of opiate-withdrawn animals immediately following swim stress testing displayed diminished efflux of tritiated dopamine after two in vitro exposures to cocaine or amphetamine. Cocaine increases neurotransmitter efflux through blockade of dopamine reuptake, while amphetamine augments efflux by stimulating release of dopamine from intracellular storage vesicles. Although slices from opiate withdrawal subjects showed decreases in efflux after in vitro treatment with these agents, no differences were observed after exposure to 4-aminopyridine, which increases neurotransmitter release by prolonging action potential duration. These findings indicate mechanisms of action that are specific for catecholamine neurotransmitter systems are important for demonstrating long-term changes in dopaminergic function following opiate withdrawal. Selegiline prevented decreases in the efflux of tritiated dopamine in slices obtained from opiate-withdrawn subjects. In addition, selegiline decreased withdrawal-induced immobility during warm water swim testing. In conclusion, treatment with selegiline can prevent long-term changes in stress-induced immobility and deficits in presynaptic dopaminergic function that occur following the

Linking electricity and water models to assess electricity choices at water-relevant scales

International Nuclear Information System (INIS)

Sattler, S; Rogers, J; Macknick, J; Lopez, A; Yates, D; Flores-Lopez, F

2012-01-01

Hydrology/water management and electricity generation projections have been modeled separately, but there has been little effort in intentionally and explicitly linking the two sides of the water–energy nexus. This paper describes a platform for assessing power plant cooling water withdrawals and consumption under different electricity pathways at geographic and time scales appropriate for both electricity and hydrology/water management. This platform uses estimates of regional electricity generation by the Regional Energy Deployment System (ReEDS) as input to a hydrologic and water management model—the Water Evaluation and Planning (WEAP) system. In WEAP, this electricity use represents thermoelectric cooling water withdrawals and consumption within the broader, regional water resource context. Here we describe linking the electricity and water models, including translating electricity generation results from ReEDS-relevant geographies to the water-relevant geographies of WEAP. The result of this analysis is water use by the electric sector at the regional watershed level, which is used to examine the water resource implications of these electricity pathways. (letter)

Estimated use of water in South Dakota, 2005

Science.gov (United States)

Carter, Janet M.; Neitzert, Kathleen M.

2008-01-01

During 2005, withdrawals from ground-water and surface-water sources in South Dakota for the eight categories of offstream use totaled about 500 million gallons per day (Mgal/d). Of total withdrawals, about 271 Mgal/d was withdrawn from ground water and about 230 Mgal/d was withdrawn from surface water. The largest use of water in South Dakota during 2005 was irrigation, which accounted for about 58 percent of the total water withdrawn, followed by public supply, which accounted for about 20 percent of withdrawals. Public-supply systems served about 666,210 people, or about 86 percent of South Dakota's population in 2005. Public-supply systems withdrew about 100 Mgal/d in 2005. Ground-water withdrawals accounted for about 66 percent of the total withdrawals (66 Mgal/d), and surface-water withdrawals accounted for about 34 percent of total withdrawals (35 Mgal/d). Total public-supply withdrawals averaged about 151 gallons per day (gal/d) per capita. About 65 percent of the public-supply water was used for domestic purposes, and the average per capita domestic use was 99 gal/d. Self-supplied domestic withdrawals were about 8 Mgal/d, all of which was from ground water. About 109,750 people obtained household water from private wells in 2005, and per capita use was about 70 gal/d. Industrial self-supplied water use during 2005 was about 4 Mgal/d, of which about 98 percent was from ground water and about 2 percent was from surface water. Total withdrawals for thermoelectric use were about 5 Mgal/d, of which about 1 Mgal/d was from ground water and about 4 Mgal/d was from surface water. Total mining water use was about 10 Mgal/d, of which about 5 Mgal/d came from ground water and about 6 Mgal/d came from surface water. Total livestock water use was about 48 Mgal/d, of which about 19 Mgal/d came from ground water and about 28 Mgal/d came from surface water. Total aquaculture use was about 33 Mgal/d, of which about 19 Mgal/d came from ground water and about 14 Mgal/d came

Projected freshwater withdrawals in the United States under a changing climate

Science.gov (United States)

Thomas C. Brown; Romano Foti; Jorge A. Ramirez

2013-01-01

Relying on the U.S. Geological Survey water use data for the period 1960 2005, this paper summarizes past water use and then projects future water use based on the trends in water use efficiency and major drivers of water use. Water use efficiency has improved in most sectors. Over the past 45 years, withdrawals in industry and at thermoelectric plants have steadily...

Regional Responses to Constrained Water Availability

Science.gov (United States)

Cui, Y.; Calvin, K. V.; Hejazi, M. I.; Clarke, L.; Kim, S. H.; Patel, P.

2017-12-01

There have been many concerns about water as a constraint to agricultural production, electricity generation, and many other human activities in the coming decades. Nevertheless, how different countries/economies would respond to such constraints has not been explored. Here, we examine the responding mechanism of binding water availability constraints at the water basin level and across a wide range of socioeconomic, climate and energy technology scenarios. Specifically, we look at the change in water withdrawals between energy, land-use and other sectors within an integrated framework, by using the Global Change Assessment Model (GCAM) that also endogenizes water use and allocation decisions based on costs. We find that, when water is taken into account as part of the production decision-making, countries/basins in general fall into three different categories, depending on the change of water withdrawals and water re-allocation between sectors. First, water is not a constraining factor for most of the basins. Second, advancements in water-saving technologies of the electricity generation cooling systems are sufficient of reducing water withdrawals to meet binding water availability constraints, such as in China and the EU-15. Third, water-saving in the electricity sector alone is not sufficient and thus cannot make up the lowered water availability from the binding case; for example, many basins in Pakistan, Middle East and India have to largely reduce irrigated water withdrawals by either switching to rain-fed agriculture or reducing production. The dominant responding strategy for individual countries/basins is quite robust across the range of alternate scenarios that we test. The relative size of water withdrawals between energy and agriculture sectors is one of the most important factors that affect the dominant mechanism.

Putting Flow–Ecology Relationships into Practice: A Decision-Support System to Assess Fish Community Response to Water-Management Scenarios

Directory of Open Access Journals (Sweden)

Jennifer Cartwright

2017-03-01

Full Text Available This paper presents a conceptual framework to operationalize flow–ecology relationships into decision-support systems of practical use to water-resource managers, who are commonly tasked with balancing multiple competing socioeconomic and environmental priorities. We illustrate this framework with a case study, whereby fish community responses to various water-management scenarios were predicted in a partially regulated river system at a local watershed scale. This case study simulates management scenarios based on interactive effects of dam operation protocols, withdrawals for municipal water supply, effluent discharges from wastewater treatment, and inter-basin water transfers. Modeled streamflow was integrated with flow–ecology relationships relating hydrologic departure from reference conditions to fish species richness, stratified by trophic, reproductive, and habitat characteristics. Adding a hypothetical new water-withdrawal site was predicted to increase the frequency of low-flow conditions with adverse effects for several fish groups. Imposition of new reservoir release requirements was predicted to enhance flow and fish species richness immediately downstream of the reservoir, but these effects were dissipated further downstream. The framework presented here can be used to translate flow–ecology relationships into evidence-based management by developing decision-support systems for conservation of riverine biodiversity while optimizing water availability for human use.

Putting flow-ecology relationships into practice: A decision-support system to assess fish community response to water-management scenarios

Science.gov (United States)

Cartwright, Jennifer M.; Caldwell, Casey; Nebiker, Steven; Knight, Rodney

2017-01-01

This paper presents a conceptual framework to operationalize flow–ecology relationships into decision-support systems of practical use to water-resource managers, who are commonly tasked with balancing multiple competing socioeconomic and environmental priorities. We illustrate this framework with a case study, whereby fish community responses to various water-management scenarios were predicted in a partially regulated river system at a local watershed scale. This case study simulates management scenarios based on interactive effects of dam operation protocols, withdrawals for municipal water supply, effluent discharges from wastewater treatment, and inter-basin water transfers. Modeled streamflow was integrated with flow–ecology relationships relating hydrologic departure from reference conditions to fish species richness, stratified by trophic, reproductive, and habitat characteristics. Adding a hypothetical new water-withdrawal site was predicted to increase the frequency of low-flow conditions with adverse effects for several fish groups. Imposition of new reservoir release requirements was predicted to enhance flow and fish species richness immediately downstream of the reservoir, but these effects were dissipated further downstream. The framework presented here can be used to translate flow–ecology relationships into evidence-based management by developing decision-support systems for conservation of riverine biodiversity while optimizing water availability for human use.

Emergence of dormant conditioned incentive approach by conditioned withdrawal in nicotine addiction.

Science.gov (United States)

Scott, Daniel; Hiroi, Noboru

2010-10-15

Nicotine is one of the determinants for the development of persistent smoking, and this maladaptive behavior is characterized by many symptoms, including withdrawal and nicotine seeking. The process by which withdrawal affects nicotine seeking is poorly understood. The impact of a withdrawal-associated cue on nicotine (.2 mg/kg)-conditioned place preference was assessed in male C57BL/6J mice (n = 8-17/group). To establish a cue selectively associated with withdrawal distinct from those associated with nicotine, a tone was paired with withdrawal in their home cages; mice were chronically exposed to nicotine (200 μg/mL for 15 days) from drinking water in their home cages and received the nicotinic acetylcholine receptor antagonist mecamylamine (2.5 mg/kg) to precipitate withdrawal in the presence of a tone. The effect of the withdrawal-associated tone on nicotine-conditioned place preference was then evaluated in the place-conditioning apparatus after a delay, when nicotine-conditioned place preference spontaneously disappeared. A cue associated with precipitated withdrawal reactivated the dormant effect of nicotine-associated cues on conditioned place preference. This effect occurred during continuous exposure to nicotine but not during abstinence. A conditioned withdrawal cue could directly amplify the incentive properties of cues associated with nicotine. This observation extends the contemporary incentive account of the role of withdrawal in addiction to cue-cue interaction. Copyright © 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Estimated water use in Puerto Rico, 2010

Science.gov (United States)

Molina-Rivera, Wanda L.

2014-01-01

Water-use data were aggregated for the 78 municipios of the Commonwealth of Puerto Rico for 2010. Five major offstream categories were considered: public-supply water withdrawals and deliveries, domestic and industrial self-supplied water use, crop-irrigation water use, and thermoelectric-power freshwater use. One instream water-use category also was compiled: power-generation instream water use (thermoelectric saline withdrawals and hydroelectric power). Freshwater withdrawals for offstream use from surface-water [606 million gallons per day (Mgal/d)] and groundwater (118 Mgal/d) sources in Puerto Rico were estimated at 724 million gallons per day. The largest amount of freshwater withdrawn was by public-supply water facilities estimated at 677 Mgal/d. Public-supply domestic water use was estimated at 206 Mgal/d. Fresh groundwater withdrawals by domestic self-supplied users were estimated at 2.41 Mgal/d. Industrial self-supplied withdrawals were estimated at 4.30 Mgal/d. Withdrawals for crop irrigation purposes were estimated at 38.2 Mgal/d, or approximately 5 percent of all offstream freshwater withdrawals. Instream freshwater withdrawals by hydroelectric facilities were estimated at 556 Mgal/d and saline instream surface-water withdrawals for cooling purposes by thermoelectric-power facilities was estimated at 2,262 Mgal/d.

Impact of feed withdrawal and addition of acetic acid in drinking ...

African Journals Online (AJOL)

ALI GILANI

2012-11-02

Nov 2, 2012 ... 1.5, 3, 4.5 or 6% acetic acid added to their drinking water with feed ... contents of birds with acidified water in comparison to the control and feed withdrawal treatments. .... more hygienic evisceration process or lower microbial.

Nicotine Withdrawal Induces Neural Deficits in Reward Processing.

Science.gov (United States)

Oliver, Jason A; Evans, David E; Addicott, Merideth A; Potts, Geoffrey F; Brandon, Thomas H; Drobes, David J

2017-06-01

Nicotine withdrawal reduces neurobiological responses to nonsmoking rewards. Insight into these reward deficits could inform the development of targeted interventions. This study examined the effect of withdrawal on neural and behavioral responses during a reward prediction task. Smokers (N = 48) attended two laboratory sessions following overnight abstinence. Withdrawal was manipulated by having participants smoke three regular nicotine (0.6 mg yield; satiation) or very low nicotine (0.05 mg yield; withdrawal) cigarettes. Electrophysiological recordings of neural activity were obtained while participants completed a reward prediction task that involved viewing four combinations of predictive and reward-determining stimuli: (1) Unexpected Reward; (2) Predicted Reward; (3) Predicted Punishment; (4) Unexpected Punishment. The task evokes a medial frontal negativity that mimics the phasic pattern of dopaminergic firing in ventral tegmental regions associated with reward prediction errors. Nicotine withdrawal decreased the amplitude of the medial frontal negativity equally across all trial types (p nicotine dependence (p Nicotine withdrawal had equivocal impact across trial types, suggesting reward processing deficits are unlikely to stem from changes in phasic dopaminergic activity during prediction errors. Effects on tonic activity may be more pronounced. Pharmacological interventions directly targeting the dopamine system and behavioral interventions designed to increase reward motivation and responsiveness (eg, behavioral activation) may aid in mitigating withdrawal symptoms and potentially improving smoking cessation outcomes. Findings from this study indicate nicotine withdrawal impacts reward processing signals that are observable in smokers' neural activity. This may play a role in the subjective aversive experience of nicotine withdrawal and potentially contribute to smoking relapse. Interventions that address abnormal responding to both pleasant and

A system model for assessing vehicle use-phase water consumption in urban mobility networks

International Nuclear Information System (INIS)

Yen, Jeff; Bras, Bert

2012-01-01

Water consumption is emerging as an important issue potentially influencing the composition of future urban transportation networks, especially as projected urban populations are expected to outpace water availability and as alternative fuels and vehicles are being implemented in such regions. National and State policies aimed at reducing dependence on imported fuels and energy can increase local production of fuels and energy, impacting demand on local water resources. This article details the development of a model-based assessment on water consumption and withdrawal pertaining to the use-phase of conventional and alternative transportation modes based on regional energy and fuel production. An extensive literature review details water consumption from fuel extraction, processing, and distribution as well as power plant operations. Using Model-Based Systems Engineering principles and the Systems Modeling Language, a multi-level, multi-modal framework was developed and applied to the Metro Atlanta transportation system consisting of conventional and alternative vehicles across varying conditions. According to the analysis, vehicles powered by locally produced biofuels and electricity (assuming average local grid mix for charging) consume more water than locally refined gasoline and CNG-powered vehicles. Improvements in power plant technologies, electricity generation (e.g., use of solar and wind versus hydro power) and vehicle efficiencies can reduce such water consumption significantly. Total water withdrawal for each vehicle and fuel is significantly greater than water consumption. - Highlights: ► A model was made to assess the local water consumption due to conventional and alternatively powered vehicles in a city. ► Water consumed in the local and external production of various fuels was reviewed and included. ► Basic battery electric and biofuel powered vehicles consume on average more water than conventional gasoline and Compressed Natural Gas (CNG

Neural mechanisms underlying morphine withdrawal in addicted patients: a review

Directory of Open Access Journals (Sweden)

Nima Babhadiashar

2015-06-01

Full Text Available Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly on the central nervous system; nonetheless, its chronic abuse increases tolerance and physical dependence, which is commonly known as opiate addiction. Morphine withdrawal syndrome is physiological and behavioral symptoms that stem from prolonged exposure to morphine. A majority of brain regions are hypofunctional over prolonged abstinence and acute morphine withdrawal. Furthermore, several neural mechanisms are likely to contribute to morphine withdrawal. The present review summarizes the literature pertaining to neural mechanisms underlying morphine withdrawal. Despite the fact that morphine withdrawal is a complex process, it is suggested that neural mechanisms play key roles in morphine withdrawal.

Hydrogeology and water quality of the Floridan aquifer system and effect of Lower Floridan aquifer withdrawals on the Upper Floridan aquifer at Barbour Pointe Community, Chatham County, Georgia, 2013

Science.gov (United States)

Gonthier, Gerard; Clarke, John S.

2016-06-02

Two test wells were completed at the Barbour Pointe community in western Chatham County, near Savannah, Georgia, in 2013 to investigate the potential of using the Lower Floridan aquifer as a source of municipal water supply. One well was completed in the Lower Floridan aquifer at a depth of 1,080 feet (ft) below land surface; the other well was completed in the Upper Floridan aquifer at a depth of 440 ft below land surface. At the Barbour Pointe test site, the U.S. Geological Survey completed electromagnetic (EM) flowmeter surveys, collected and analyzed water samples from discrete depths, and completed a 72-hour aquifer test of the Floridan aquifer system withdrawing from the Lower Floridan aquifer.Based on drill cuttings, geophysical logs, and borehole EM flowmeter surveys collected at the Barbour Pointe test site, the Upper Floridan aquifer extends 369 to 567 ft below land surface, the middle semiconfining unit, separating the two aquifers, extends 567 to 714 ft below land surface, and the Lower Floridan aquifer extends 714 to 1,056 ft below land surface.A borehole EM flowmeter survey indicates that the Upper Floridan and Lower Floridan aquifers each contain four water-bearing zones. The EM flowmeter logs of the test hole open to the entire Floridan aquifer system indicated that the Upper Floridan aquifer contributed 91 percent of the total flow rate of 1,000 gallons per minute; the Lower Floridan aquifer contributed about 8 percent. Based on the transmissivity of the middle semiconfining unit and the Floridan aquifer system, the middle semiconfining unit probably contributed on the order of 1 percent of the total flow.Hydraulic properties of the Upper Floridan and Lower Floridan aquifers were estimated based on results of the EM flowmeter survey and a 72-hour aquifer test completed in Lower Floridan aquifer well 36Q398. The EM flowmeter data were analyzed using an AnalyzeHOLE-generated model to simulate upward borehole flow and determine the transmissivity of

Data model and relational database design for the New England Water-Use Data System (NEWUDS)

Science.gov (United States)

Tessler, Steven

2001-01-01

The New England Water-Use Data System (NEWUDS) is a database for the storage and retrieval of water-use data. NEWUDS can handle data covering many facets of water use, including (1) tracking various types of water-use activities (withdrawals, returns, transfers, distributions, consumptive-use, wastewater collection, and treatment); (2) the description, classification and location of places and organizations involved in water-use activities; (3) details about measured or estimated volumes of water associated with water-use activities; and (4) information about data sources and water resources associated with water use. In NEWUDS, each water transaction occurs unidirectionally between two site objects, and the sites and conveyances form a water network. The core entities in the NEWUDS model are site, conveyance, transaction/rate, location, and owner. Other important entities include water resources (used for withdrawals and returns), data sources, and aliases. Multiple water-exchange estimates can be stored for individual transactions based on different methods or data sources. Storage of user-defined details is accommodated for several of the main entities. Numerous tables containing classification terms facilitate detailed descriptions of data items and can be used for routine or custom data summarization. NEWUDS handles single-user and aggregate-user water-use data, can be used for large or small water-network projects, and is available as a stand-alone Microsoft? Access database structure. Users can customize and extend the database, link it to other databases, or implement the design in other relational database applications.

Simulation of the Regional Ground-Water-Flow System and Ground-Water/Surface-Water Interaction in the Rock River Basin, Wisconsin

Science.gov (United States)

Juckem, Paul F.

2009-01-01

A regional, two-dimensional, areal ground-water-flow model was developed to simulate the ground-water-flow system and ground-water/surface-water interaction in the Rock River Basin. The model was developed by the U.S. Geological Survey (USGS), in cooperation with the Rock River Coalition. The objectives of the regional model were to improve understanding of the ground-water-flow system and to develop a tool suitable for evaluating the effects of potential regional water-management programs. The computer code GFLOW was used because of the ease with which the model can simulate ground-water/surface-water interactions, provide a framework for simulating regional ground-water-flow systems, and be refined in a stepwise fashion to incorporate new data and simulate ground-water-flow patterns at multiple scales. The ground-water-flow model described in this report simulates the major hydrogeologic features of the modeled area, including bedrock and surficial aquifers, ground-water/surface-water interactions, and ground-water withdrawals from high-capacity wells. The steady-state model treats the ground-water-flow system as a single layer with hydraulic conductivity and base elevation zones that reflect the distribution of lithologic groups above the Precambrian bedrock and a regionally significant confining unit, the Maquoketa Formation. In the eastern part of the Basin where the shale-rich Maquoketa Formation is present, deep ground-water flow in the sandstone aquifer below the Maquoketa Formation was not simulated directly, but flow into this aquifer was incorporated into the GFLOW model from previous work in southeastern Wisconsin. Recharge was constrained primarily by stream base-flow estimates and was applied uniformly within zones guided by regional infiltration estimates for soils. The model includes average ground-water withdrawals from 1997 to 2006 for municipal wells and from 1997 to 2005 for high-capacity irrigation, industrial, and commercial wells. In addition

TRACY transient experiment databook. 2) ramp withdrawal experiment

International Nuclear Information System (INIS)

Nakajima, Ken; Yamane, Yuichi; Ogawa, Kazuhiko; Aizawa, Eiju; Yanagisawa, Hiroshi; Miyoshi, Yoshinori

2002-03-01

This is a databook of TRACY ''ramp withdrawal'' experiments. TRACY is a reactor to perform supercritical experiments using low-enriched uranyl nitrate aqueous solution. The excess reactivity of TRACY is 3$ at maximum, and it is inserted by feeding the solution to a core tank or by withdrawing a control rod, which is called as the transient rod, from the core. In the ramp withdrawal experiment, the supercritical experiment is initiated by withdrawing the transient rod from the core in a constant speed using a motor drive system. The data in the present databook consist of datasheets and graphs. Experimental conditions and typical values of measured parameters are tabulated in the datasheet. In the graph, power and temperature profiles are plotted. Those data are useful for the investigation of criticality accidents with fissile solutions, and for validation of criticality accident analysis codes. (author)

Withdrawal: Expanding a Key Addiction Construct.

Science.gov (United States)

Piper, Megan E

2015-12-01

Withdrawal is an essential component of classical addiction theory; it is a vital manifestation of dependence and motivates relapse. However, the traditional conceptualization of withdrawal as a cohesive collection of symptoms that emerge during drug deprivation and decline with either the passage of time or reinstatement of drug use, may be inadequate to explain scientific findings or fit with modern theories of addiction. This article expands the current understanding of tobacco withdrawal by examining: (1) withdrawal variability; (2) underlying causes of withdrawal variability, including biological and person factors, environmental influences, and the influence of highly routinized behavioral patterns; (3) new withdrawal symptoms that allow for enhanced characterization of the withdrawal experience; and (4) withdrawal-related cognitive processes. These topics provide guidance regarding the optimal assessment of withdrawal and illustrate the potential impact modern withdrawal conceptualization and assessment could have on identifying treatment targets. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Neonatal opioid withdrawal syndrome.

Science.gov (United States)

Sutter, Mary Beth; Leeman, Lawrence; Hsi, Andrew

2014-06-01

Neonatal opioid withdrawal syndrome is common due to the current opioid addiction epidemic. Infants born to women covertly abusing prescription opioids may not be identified as at risk until withdrawal signs present. Buprenorphine is a newer treatment for maternal opioid addiction and appears to result in a milder withdrawal syndrome than methadone. Initial treatment is with nonpharmacological measures including decreasing stimuli, however pharmacological treatment is commonly required. Opioid monotherapy is preferred, with phenobarbital or clonidine uncommonly needed as adjunctive therapy. Rooming-in and breastfeeding may decease the severity of withdrawal. Limited evidence is available regarding long-term effects of perinatal opioid exposure. Copyright © 2014 Elsevier Inc. All rights reserved.

76 FR 59960 - Hazardous Waste Management System; Identification and Listing of Hazardous Waste; Withdrawal of...

Science.gov (United States)

2011-09-28

... Waste Management System; Identification and Listing of Hazardous Waste; Withdrawal of proposed rule... Permitting Division, Corrective Action and Waste Minimization Section (6PD-C), 1445 Ross Avenue, Dallas, TX... petition. A new petition will be required for this waste stream. List of Subjects in 40 CFR Part 261...

Control rod withdrawal monitoring device

International Nuclear Information System (INIS)

Ebisuya, Mitsuo.

1984-01-01

Purpose: To prevent the power ramp even if a plurality of control rods are subjected to withdrawal operation at a time, by reducing the reactivity applied to the reactor. Constitution: The control rod withdrawal monitoring device is adapted to monitor and control the withdrawal of the control rods depending on the reactor power and the monitoring region thereof is divided into a control rod group monitoring region a transition region and a control group monitoring not interfere region. In a case if the distance between a plurality of control rods for which the withdrawal positions are selected is less than a limiting value, the coordinate for the control rods, distance between the control rods and that the control rod distance is shorter are displayed on a display panel, and the withdrawal for the control rods are blocked. Accordingly, even if a plurality of control rods are subjected successively to the withdrawal operation contrary to the control rod withdrawal sequence upon high power operation of the reactor, the power ramp can be prevented. (Kawakami, Y.)

Regional water coefficients for U.S. industrial sectors

Directory of Open Access Journals (Sweden)

Riccardo Boero

2017-12-01

Full Text Available Designing policies for water systems management requires the capability to assess the economic impacts of water availability and to effectively couple water withdrawals by human activities with natural hydrologic dynamics. At the core of any scientific approach to these issues there is the estimation of water withdrawals by industrial sectors in the form of water coefficients, which are measurements of the quantity of water withdrawn per dollar of GDP or output. In this work we focus on the contiguous United States and on the estimation of water coefficients for regional scale analyses. We first compare an established methodology for the estimation of national water coefficients with a parametric one we propose. Second, we introduce a method to estimate water coefficients at the level of ecological regions and we discuss how they reduce possible biases in regional analyses of water systems. We conclude discussing advantages and limits of regional water coefficients.

Impacts of Combined Cooling, Heating and Power Systems, and Rainwater Harvesting on Water Demand, Carbon Dioxide, and NOx Emissions for Atlanta.

Science.gov (United States)

James, Jean-Ann; Sung, Sangwoo; Jeong, Hyunju; Broesicke, Osvaldo A; French, Steven P; Li, Duo; Crittenden, John C

2018-01-02

The purpose of this study is to explore the potential water, CO 2 and NO x emission, and cost savings that the deployment of decentralized water and energy technologies within two urban growth scenarios can achieve. We assess the effectiveness of urban growth, technological, and political strategies to reduce these burdens in the 13-county Atlanta metropolitan region. The urban growth between 2005 and 2030 was modeled for a business as usual (BAU) scenario and a more compact growth (MCG) scenario. We considered combined cooling, heating and power (CCHP) systems using microturbines for our decentralized energy technology and rooftop rainwater harvesting and low flow fixtures for the decentralized water technologies. Decentralized water and energy technologies had more of an impact in reducing the CO 2 and NO x emissions and water withdrawal and consumption than an MCG growth scenario (which does not consider energy for transit). Decentralized energy can reduce the CO 2 and NO x emissions by 8% and 63%, respectively. Decentralized energy and water technologies can reduce the water withdrawal and consumption in the MCG scenario by 49% and 50% respectively. Installing CCHP systems on both the existing and new building stocks with a net metering policy could reduce the CO 2 , NO x , and water consumption by 50%, 90%, and 75% respectively.

Power-law Growth and Punctuated Equilibrium Dynamics in Water Resources Systems

Science.gov (United States)

Parolari, A.; Katul, G. G.; Porporato, A. M.

2015-12-01

The global rise in population-driven water scarcity and recent appreciation of strong dynamic coupling between human and natural systems has called for new approaches to predict the future sustainability of regional and global water resources systems. The dynamics of coupled human-water systems are driven by a complex set of social, environmental, and technological factors. Present projections of water resources systems range from a finite carrying capacity regulated by accessible freshwater, or `peak renewable water,' to punctuated evolution with new supplied and improved efficiency gained from technological and social innovation. However, these projections have yet to be quantified from observations or in a comprehensive theoretical framework. Using data on global water withdrawals and storage capacity of regional water supply systems, non-trivial dynamics are identified in water resources systems development over time, including power-law growth and punctuated equilibria. Two models are introduced to explain this behavior: (1) a delay differential equation and (2) a power-law with log-periodic oscillations, both of which rely on past conditions (or system memory) to describe the present rate of growth in the system. In addition, extension of the first model demonstrates how system delays and punctuated equilibria can emerge from coupling between human population growth and associated resource demands. Lastly, anecdotal evidence is used to demonstrate the likelihood of power-law growth in global water use from the agricultural revolution 3000 BC to the present. In a practical sense, the presence of these patterns in models with delayed oscillations suggests that current decision-making related to water resources development results from the historical accumulation of resource use decisions, technological and social changes, and their consequences.

Earth observation based assessment of the water production and water consumption of Nile Basin agro-ecosystems

Science.gov (United States)

Bastiaanssen, Wim G.M.; Karimi, Poolad; Rebelo, Lisa-Maria; Duan, Zheng; Senay, Gabriel; Muthuwatte, Lal; Smakhtin, Vladimir

2014-01-01

The increasing competition for water resources requires a better understanding of flows, fluxes, stocks, and the services and benefits related to water consumption. This paper explains how public domain Earth Observation data based on Moderate Resolution Imaging Spectroradiometer (MODIS), Second Generation Meteosat (MSG), Tropical Rainfall Measurement Mission (TRMM) and various altimeter measurements can be used to estimate net water production (rainfall (P) > evapotranspiration (ET)) and net water consumption (ET > P) of Nile Basin agro-ecosystems. Rainfall data from TRMM and the Famine Early Warning System Network (FEWS-NET) RainFall Estimates (RFE) products were used in conjunction with actual evapotranspiration from the Operational Simplified Surface Energy Balance (SSEBop) and ETLook models. Water flows laterally between net water production and net water consumption areas as a result of runoff and withdrawals. This lateral flow between the 15 sub-basins of the Nile was estimated, and partitioned into stream flow and non-stream flow using the discharge data. A series of essential water metrics necessary for successful integrated water management are explained and computed. Net water withdrawal estimates (natural and humanly instigated) were assumed to be the difference between net rainfall (Pnet) and actual evapotranspiration (ET) and some first estimates of withdrawals—without flow meters—are provided. Groundwater-dependent ecosystems withdraw large volumes of groundwater, which exceed water withdrawals for the irrigation sector. There is a strong need for the development of more open-access Earth Observation databases, especially for information related to actual ET. The fluxes, flows and storage changes presented form the basis for a global framework to describe monthly and annual water accounts in ungauged river basins.

Hydrology and numerical simulation of groundwater flow and streamflow depletion by well withdrawals in the Malad-Lower Bear River Area, Box Elder County, Utah

Science.gov (United States)

Stolp, Bernard J.; Brooks, Lynette E.; Solder, John

2017-03-28

The Malad-Lower Bear River study area in Box Elder County, Utah, consists of a valley bounded by mountain ranges and is mostly agricultural or undeveloped. The Bear and Malad Rivers enter the study area with a combined average flow of about 1,100,000 acre-feet per year (acre-ft/yr), and this surface water dominates the hydrology. Groundwater occurs in consolidated rock and basin fill. Groundwater recharge occurs from precipitation in the mountains and moves through consolidated rock to the basin fill. Recharge occurs in the valley from irrigation. Groundwater discharge occurs to rivers, springs and diffuse seepage areas, evapotranspiration, field drains, and wells. Groundwater, including springs, is a source for municipal and domestic water supply. Although withdrawal from wells is a small component of the groundwater budget, there is concern that additional groundwater development will reduce the amount of flow in the Malad River. Historical records of surface-water diversions, land use, and groundwater levels indicate relatively stable hydrologic conditions from the 1960s to the 2010s, and that current groundwater development has had little effect on the groundwater system. Average annual recharge to and discharge from the groundwater flow system are estimated to be 164,000 and 228,000 acre-ft/yr, respectively. The imbalance between recharge and discharge represents uncertainties resulting from system complexities, and the possibility of groundwater inflow from surrounding basins.This study reassesses the hydrologic system, refines the groundwater budget, and creates a numerical groundwater flow model that is used to analyze the effects of groundwater withdrawals on surface water. The model uses the detailed catalog of locations and amounts of groundwater recharge and discharge defined during this study. Calibrating the model to adequately simulate recharge, discharge, and groundwater levels results in simulated aquifer properties that can be used to understand

Simulated effects of increased groundwater withdrawals in the Cave Springs area, Hixson, Tennessee

Science.gov (United States)

Haugh, Connor J.

2014-01-01

Concern for future water supplies in Tennessee has grown in recent years as a result of increased awareness of competing needs, the impact of droughts, and the need for more water to support growing populations. The U.S. Geological Survey conducts investigations to improve the knowledge about interactions of geology, climate, humans, and ecosystems with the water cycle, which is critical to understanding and optimizing water availability. The Hixson Utility District in Hamilton County, Tennessee, uses groundwater resources in the Cave Springs area as a water supply, withdrawing water from two well fields located at Cave Springs and Walkers Corner. Historically, Hixson Utility District has withdrawn about 5 million gallons per day (Mgal/d) at the Cave Springs well field and between 2 and 3 Mgal/d at the Walkers Corner well field. To assess the capacity of the groundwater resources in the Cave Springs area to meet future demands, four different scenarios of increased groundwater withdrawals were analyzed using computer model simulations.

Artificial groundwater recharge as integral part of a water resources system in a humid environment

Science.gov (United States)

Kupfersberger, Hans; Stadler, Hermann

2010-05-01

In Graz, Austria, artificial groundwater recharge has been operated as an integral part of the drinking water supply system for more than thirty years. About 180 l/s of high quality water from pristine creeks (i.e. no pre-treatment necessary) are infiltrated via sand and lawn basins and infiltration trenches into two phreatic aquifers to sustain the extraction of approximately 400 l/s. The remaining third of drinking water for roughly 300.000 people is provided by a remote supply line from the East alpine karst region Hochschwab. By this threefold model the water supply system is less vulnerable to external conditions. In the early 1980's the infiltration devices were also designed as a hydraulic barrier against riverbank infiltration from the river Mur, which at that time showed seriously impaired water quality due to upstream paper mills. This resulted into high iron and manganese groundwater concentrations which lead to clogging of the pumping wells. These problems have been eliminated in the meantime due to the onsite purification of paper mill effluents and the construction of many waste water treatment plants. The recharge system has recently been thoroughly examined to optimize the operation of groundwater recharge and to provide a basis for further extension. The investigations included (i) field experiments and laboratory analyses to improve the trade off between infiltration rate and elimination capacities of the sand filter basins' top layer, (ii) numerical groundwater modelling to compute the recovery rate of the recharged water, the composition of the origin of the pumped water, emergency scenarios due to the failure of system parts, the transient capture zones of the withdrawal wells and the coordination of recharge and withdrawal and (iii) development of an online monitoring setup combined with a decision support system to guarantee reliable functioning of the entire structure. Additionally, the depreciation, maintenance and operation costs of the

Automation of irrigation systems to control irrigation applications and crop water use efficiency

Science.gov (United States)

Agricultural irrigation management to slow water withdrawals from non-replenishing quality water resources is a global endeavor and vital to sustaining irrigated agriculture and dependent rural economies. Research in site-specific irrigation management has shown that water use efficiency, and crop p...

Reassessment of Ground-Water Recharge and Simulated Ground-Water Availability for the Hawi Area of North Kohala, Hawaii

Science.gov (United States)

Oki, Delwyn S.

2002-01-01

An estimate of ground-water availability in the Hawi area of north Kohala, Hawaii, is needed to determine whether ground-water resources are adequate to meet future demand within the area and other areas to the south. For the Hawi area, estimated average annual recharge from infiltration of rainfall, fog drip, and irrigation is 37.5 million gallons per day from a daily water budget. Low and high annual recharge estimates for the Hawi area that incorporate estimated uncertainty are 19.9 and 55.4 million gallons per day, respectively. The recharge estimates from this study are lower than the recharge of 68.4 million gallons per day previously estimated from a monthly water budget. Three ground-water models, using the low, intermediate, and high recharge estimates (19.9, 37.5, and 55.4 million gallons per day, respectively), were developed for the Hawi area to simulate ground-water levels and discharges for the 1990?s. To assess potential ground-water availability, the numerical ground-water flow models were used to simulate the response of the freshwater-lens system to withdrawals at rates in excess of the average 1990?s withdrawal rates. Because of uncertainty in the recharge estimate, estimates of ground-water availability also are uncertain. Results from numerical simulations indicate that for appropriate well sites, depths, and withdrawal rates (1) for the low recharge estimate (19.9 million gallons per day) it may be possible to develop an additional 10 million gallons per day of fresh ground water from the Hawi area and maintain a freshwater-lens thickness of 160 feet near the withdrawal sites, (2) for the intermediate recharge estimate (37.5 million gallons per day) it may be possible to develop an additional 15 million gallons per day of fresh ground water from the Hawi area and maintain a freshwater-lens thickness of 190 feet near the withdrawal sites, and (3) for the high recharge estimate (55.4 million gallons per day) it may be possible to develop at

Low efficacy of non-opioid drugs in opioid withdrawal symptoms.

Science.gov (United States)

Hermann, Derik; Klages, Eckard; Welzel, Helga; Mann, Karl; Croissant, Bernhard

2005-06-01

Opioid withdrawal, stress or cues associated with opioid consumption can induce opioid craving. If opioids are not available, opioid-dependent patients usually search for alternative drugs. Because several non-opioid drugs stimulate the endogenous opioidergic system, this concept may explain their frequent use by opioid-dependent patients. We hypothesized that non-opioid drugs alleviate opioid withdrawal symptoms and are therefore consumed by opioid addicts. We asked 89 opioid-dependent patients participating in an out-patient opioid maintenance program to estimate the potential of several non-opioid drugs in being able to alleviate opioid withdrawal. We applied a five-point Lickert scale (1 = very good reduction of opioid withdrawal; 5 = no reduction of opioid withdrawal). Patients could also indicate a worsening of opioid withdrawal. Values (mean +/- SD) were: for benzodiazepines, 3.2 +/- 1.1; tricyclic antidepressants, 3.6 +/- 1.1; cannabis, 3.6 +/- 1.0; alcohol, 4.1 +/- 1.1; cocaine, 4.2 +/- 1.1; amphetamine, 4.4 +/- 0.9; nicotine, 4.7 +/- 0.7; and caffeine, 4.9 +/- 0.5. A worsening of opioid withdrawal was reported by 62% of the patients for cocaine, 62% for amphetamine, 50% for caffeine, 37.5% for cannabis, 27% for nicotine, 26% for alcohol, 8% for tricyclic antidepressants and 3% for benzodiazepines. Our study shows a low efficacy of non-opioid drugs in alleviating opioid withdrawal symptoms. The data basis of this study was good and the sample was suitable to be asked for estimations of drug-drug interactions. Of the patients, 26 - 62% even reported a worsening of opioid withdrawal for cannabis, alcohol, cocaine and amphetamine. Only benzodiazepines and tricyclic antidepressants were reported to have a moderate positive effect on opioid withdrawal.

Conditioned flavor avoidance as a measure of withdrawal in rats chronically exposed to a caffeine solution.

Science.gov (United States)

Dreumont-Boudreau, Sarah E; Dingle, Rachel N; Alcolado, Gillian M; Lolordo, Vincent M

2008-09-03

Rats were given 21 days of chronic oral caffeine. A novel flavor (Maintenance CS) was then paired with the continuation of caffeine, and a second flavor (Withdrawal CS) was paired with caffeine removal. Rats avoided the Withdrawal CS, and drank more of the Maintenance CS in a two-bottle test, suggesting that removing caffeine had induced withdrawal. The value of the Maintenance CS was investigated by comparing it to a novel flavor paired with water (Neutral CS). In a series of two-bottle tests, the Maintenance and Neutral CSs were equivalent when pitted against each other, and both were preferred to the Withdrawal CS. These results demonstrate that conditioned flavor avoidance is a useful procedure in assessing caffeine withdrawal, and by inference dependence, produced by chronic oral consumption.

State National Pollutant Discharge Elimination System (NPDES) Program Withdrawal Petitions

Data.gov (United States)

U.S. Environmental Protection Agency — Search for pending and resolved NPDES withdrawal petitions by state, region, date, or keyword. "Pending" means EPA has received the petition and is working with the...

Is this ?complicated? opioid withdrawal?

OpenAIRE

Parkar, S.R.; Seethalakshmi, R; Adarkar, S; Kharawala, S

2006-01-01

Seven patients with opioid dependence admitted in the de-addiction centre for detoxification developed convulsions and delirium during the withdrawal phase. After ruling out all other possible causes of these complications, opioid withdrawal seemed to emerge as the most likely explanation. The unpredictability of the course of opioid dependence and withdrawal needs to be considered when treating patients with opioid dependence.

Ketogenic Diet Suppresses Alcohol Withdrawal Syndrome in Rats.

Science.gov (United States)

Dencker, Ditte; Molander, Anna; Thomsen, Morgane; Schlumberger, Chantal; Wortwein, Gitta; Weikop, Pia; Benveniste, Helene; Volkow, Nora D; Fink-Jensen, Anders

2018-02-01

Alcohol use disorder is underdiagnosed and undertreated, and up to 50% of alcohol-abstinent patients diagnosed with alcohol dependence relapse within the first year of treatment. Current treatments for the maintenance of alcohol abstinence in patients with alcohol use disorder have limited efficacy, and there is an urgent need for novel treatment strategies. Decreased cerebral glucose metabolism and increased brain uptake of acetate were recently reported in heavy drinkers, relative to controls. Given the switch of metabolic fuel from glucose to acetate in the alcohol-dependent brain, we investigated the potential therapeutic benefit of a ketogenic diet in managing alcohol withdrawal symptoms during detoxification. Male Sprague Dawley rats fed either ketogenic or regular diet were administered ethanol or water orally, twice daily for 6 days while the diet conditions were maintained. Abstinence symptoms were rated 6, 24, 48, and 72 hours after the last alcohol administration. Maintenance on a ketogenic diet caused a significant decrease in the alcohol withdrawal symptoms' "rigidity" and "irritability." Our preclinical pilot study suggests that a ketogenic diet may be a novel approach for treating alcohol withdrawal symptoms in humans. Copyright © 2017 by the Research Society on Alcoholism.

Public supply and domestic water use in the United States, 2015

Science.gov (United States)

Dieter, Cheryl A.; Maupin, Molly A.

2017-10-30

IntroductionThe U.S. Geological Survey (USGS) National Water Use Science Project (NWUSP), part of the USGS Water Availability and Use Science Program (WAUSP), has estimated water use in the United States every 5 years since 1950. This report provides an overview of total population, public-supply use, including the population that is served by public-supply systems and the domestic deliveries to those users, and self-supplied domestic water use in the United States for 2015, continuing the task of estimating water use in the United States every 5 years. In this report, estimates for the United States include the 50 States, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands (hereafter referred to as “states” for brevity).County-level data for total population, public-supply withdrawals and the population served by public-supply systems, and domestic withdrawals for 2015 were published in a data release in an effort to provide data to the public in a timely manner. Data in the current version (1.0) of Dieter and others (2017) contains county-level total withdrawals from groundwater and surface-water sources (both fresh and saline) for public-water supply, the deliveries from those suppliers to domestic users, and the quantities of water from groundwater and surface-water sources for self-supplied domestic users, and total population. Methods used to estimate the various data elements for the public-supply and domestic use categories at the county level are described by Bradley (2017).This Open-File Report is an interim report summarizing the data published in Dieter and others (2017) at the state and national level. This report includes discussions on the total population, totals for public-supply withdrawals and population served, total domestic withdrawals, and provides comparisons of the 2015 estimates to 2010 estimates (Maupin and others, 2014). Total domestic water use, as described in this report, represents the summation of deliveries from

Cerebral blood flow and oxygen consumption during ethanol withdrawal in the rat.

Science.gov (United States)

Hemmingsen, R; Barry, D I; Hertz, M M; Klinken, L

1979-09-14

The ethanol withdrawal syndrome in man and animals is characterized by signs of CNS hyperactivity although a direct measurement of a physiological variable reflecting this CNS hyperactivity has never been performed in untreated man or in animals. We induced ethanol dependence in the rat by means of intragastric intubation with a 20% w/v ethanol solution, thus keeping the animals in a state of continuous severe intoxication for 3--4 days; during the subsequent state of withdrawal characterized by tremor, rigidity, stereotyped movements and general seizures a 25% increase in cerebral oxygen consumption (CMRO2) could be measured; this increase was not due to catecholamines originating from adrenal medulla as adrenomedullectomized animals showed a similar increase in CMRO2 (28%); the withdrawing animals showed a corresponding cerebral blood flow (CBF) increase. The elevated CMRO2 and CBF could be reduced to normal by administration of a beta-adrenergic receptor blocker (propranolol 2 mg/kg i.v.), and hence the increased CMRO2 during ethanol withdrawal could be related to catecholaminergic systems in the brain, e.g. the noradrenergic locus coeruleus system which is anatomically well suited as a general activating system. This interpretation is supported by the earlier neurochemical finding of an increased cerebral noradrenaline turnover during ethanol withdrawal. The exact mechanism underlying the increased cerebral oxygen consumption during ethanol withdrawal and the effect of propranolol on cerebral function during this condition remains to be clarified.

Water use and quality of fresh surface-water resources in the Barataria-Terrebonne Basins, Louisiana

Science.gov (United States)

Johnson-Thibaut, Penny M.; Demcheck, Dennis K.; Swarzenski, Christopher M.; Ensminger, Paul A.

1998-01-01

Approximately 170 Mgal/d (million gallons per day) of ground- and surface-water was withdrawn from the Barataria-Terrebonne Basins in 1995. Of this amount, surface water accounted for 64 percent ( 110 MgaVd) of the total withdrawal rates in the basins. The largest surface-water withdrawal rates were from Bayou Lafourche ( 40 Mgal/d), Bayou Boeuf ( 14 MgaVd), and the Gulf Intracoastal Waterway (4.2 Mgal/d). The largest ground-water withdrawal rates were from the Mississippi River alluvial aquifer (29 Mgal/d), the Gonzales-New Orleans aquifer (9.5 Mgal/d), and the Norco aquifer (3.6 MgaVd). The amounts of water withdrawn in the basins in 1995 differed by category of use. Public water suppliers within the basins withdrew 41 Mgal/d of water. The five largest public water suppliers in the basins withdrew 30 Mgal/d of surface water: Terrebonne Waterworks District 1 withdrew the largest amount, almost 15 MgaVd. Industrial facilities withdrew 88 Mgal/d, fossil-fuel plants withdrew 4.7 MgaVd, and commercial facilities withdrew 0.67 MgaVd. Aggregate water-withdrawal rates, compiled by parish for aquaculture (37 Mgal/d), livestock (0.56 Mgal/d), rural domestic (0.44 MgaVd), and irrigation uses (0.54 MgaVd), totaled about 38 MgaVd in the basins. Ninety-five percent of aquaculture withdrawal rates, primarily for crawfish and alligator farming, were from surface-water sources. >br> Total water-withdrawal rates increased 221 percent from 1960–95. Surface-water withdrawal rates have increased by 310 percent, and ground-water withdrawal rates have increased by 133 percent. The projection for the total water-withdrawal rates in 2020 is 220 MgaVd, an increase of 30 percent from 1995. Surface-water withdrawal rates would account for 59 percent of the total, or 130 Mgal/d. Surface-water withdrawal rates are projected to increase by 20 percent from 1995 to 2020. Analysis of water-quality data from the Mississippi River indicates that the main threats to surface water resources are

Simulation and assessment of groundwater flow and groundwater and surface-water exchanges in lakes of the northeast Twin Cities Metropolitan Area, Minnesota, 2003 through 2013: Chapter B of Water levels and groundwater and surface-water exchanges in lakes of the northeast Twin Cities Metropolitan Area, Minnesota, 2002 through 2015

Science.gov (United States)

Jones, Perry M.; Roth, Jason L.; Trost, Jared J.; Christenson, Catherine A.; Diekoff, Aliesha L.; Erickson, Melinda L.

2017-09-05

Water levels during 2003 through 2013 were less than mean water levels for the period 1925–2013 for several lakes in the northeast Twin Cities Metropolitan Area in Minnesota. Previous periods of low lake-water levels generally were correlated with periods with less than mean precipitation. Increases in groundwater withdrawals and land-use changes have brought into question whether or not recent (2003–13) lake-water-level declines are solely caused by decreases in precipitation. A thorough understanding of groundwater and surface-water exchanges was needed to assess the effect of water-management decisions on lake-water levels. To address this need, the U.S. Geological Survey, in cooperation with the Metropolitan Council and the Minnesota Department of Health, developed and calibrated a three-dimensional, steady-state groundwater-flow model representing 2003–13 mean hydrologic conditions to assess groundwater and lake-water exchanges, and the effects of groundwater withdrawals and precipitation on water levels of 96 lakes in the northeast Twin Cities Metropolitan Area.Lake-water budgets for the calibrated groundwater-flow model indicated that groundwater is flowing into lakes in the northeast Twin Cities Metropolitan Area and lakes are providing water to underlying aquifers. Lake-water outflow to the simulated groundwater system was a major outflow component for Big Marine Lake, Lake Elmo, Snail Lake, and White Bear Lake, accounting for 45 to 64 percent of the total outflows from the lakes. Evaporation and transpiration from the lake surface ranged from 19 to 52 percent of the total outflow from the four lakes. Groundwater withdrawals and precipitation were varied from the 2003‒13 mean values used in the calibrated model (30-percent changes in groundwater withdrawals and 5-percent changes in precipitation) for hypothetical scenarios to assess the effects of groundwater withdrawals and precipitation on water budgets and levels in Big Marine Lake, Snail Lake

Scenarios for Low Carbon and Low Water Electric Power Plant Operations: Implications for Upstream Water Use.

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Dodder, Rebecca S; Barnwell, Jessica T; Yelverton, William H

2016-11-01

Electric sector water use, in particular for thermoelectric operations, is a critical component of the water-energy nexus. On a life cycle basis per unit of electricity generated, operational (e.g., cooling system) water use is substantially higher than water demands for the fuel cycle (e.g., natural gas and coal) and power plant manufacturing (e.g., equipment and construction). However, could shifting toward low carbon and low water electric power operations create trade-offs across the electricity life cycle? We compare business-as-usual with scenarios of carbon reductions and water constraints using the MARKet ALlocation (MARKAL) energy system model. Our scenarios show that, for water withdrawals, the trade-offs are minimal: operational water use accounts for over 95% of life cycle withdrawals. For water consumption, however, this analysis identifies potential trade-offs under some scenarios. Nationally, water use for the fuel cycle and power plant manufacturing can reach up to 26% of the total life cycle consumption. In the western United States, nonoperational consumption can even exceed operational demands. In particular, water use for biomass feedstock irrigation and manufacturing/construction of solar power facilities could increase with high deployment. As the United States moves toward lower carbon electric power operations, consideration of shifting water demands can help avoid unintended consequences.

Contribution of Nutrient Pollution to Water Scarcity in the Water-Rich Northeastern United States

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Hale, R. L.; Lopez, C.; Vorosmarty, C. J.

2015-12-01

Most studies of water stress focus on water-scarce regions such as drylands. Yet, even water-rich regions can be water stressed due to local water withdrawals that exceed supply or due to water pollution that makes water unusable. The northeastern United States (NE) is a water-rich region relative to the rest of the country, as it concentrates about 50% of total renewable water of the country. Yes the NE features relatively high water withdrawals, ~50 km3/yr, for thermo-power generation, agriculture, and industry, as well as to support a human population of about 70 million. At the same time, rivers and streams in the NE suffer from nutrient pollution, largely from agricultural and urban land uses. We asked: to what extent is the NE water stressed, and how do water withdrawals and water quality each contribute to water scarcity across the NE? We used information on county-level water withdrawals and runoff to calculate a water scarcity index (WSI) for 200 hydrologic units across the NE from 1987 to 2002. We used data on surface water concentrations of nitrogen to calculate the additional water necessary to dilute surface water pollution to weak, moderate, and strong water quality standards derived from the literature. Only considering withdrawals, we found that approximately 10% of the NE was water stressed. Incorporating a moderate water quality standard, 25% of the NE was water stressed. We calculated a dilution burden by sectors of water users and found that public utilities faced 41% of the total dilution burden for the region, followed by irrigation users at 21%. Our results illustrate that even water rich regions can experience water stress and even scarcity, where withdrawals exceed surface water supplies. Water quality contributes to water stress and can change the spatial patterns of water stress across a region. The common approach to address scarcity has required the use of inter-basin water transfers, or in the case of water quality-caused scarcity

On the relationship between Indian monsoon withdrawal and Iran's fall precipitation onset

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Babaeian, Iman; Rezazadeh, Parviz

2017-09-01

Indian monsoon is the most prominent of the world's monsoon systems which primarily affects synoptic patterns of India and adjacent countries such as Iran in interaction with large-scale weather systems. In this article, the relationship between the withdrawal date of the Indian monsoon and the onset of fall precipitation in Iran has been studied. Data included annual time series of withdrawal dates of the Indian monsoon prepared by the Indian Institute for Tropical Meteorology, and time series of the first date of 25 mm accumulated precipitation over Iran's synoptic weather stations in a 10-day period which is the basis for the cultivation date. Both time series were considered in Julian calendar with the starting date on August 1. The studied period is 1960-2014 which covers 55 years of data from 36 meteorological stations in Iran. By classifying the withdrawal dates of the Indian monsoon in three stages of late, normal, and early withdrawals, its relation with the onset of fall precipitation in western, southwestern, southern, eastern, central, and northern regions of Iran was studied. Results demonstrated that in four out of the six mentioned regions, the late withdrawal of the Indian monsoon postpones the onset of fall precipitation over Iran. No significant relation was found between the onset of fall precipitation in central region of Iran and the monsoon's withdrawal date. In the western, southwestern, southern, and eastern regions of Iran, the late monsoon delays the onset of fall's precipitation; while in the south Caspian Sea coastal area, it causes the early onset of autumnal precipitation. The lag in onset of fall precipitation in Iran which is coordinated with the late withdrawal of monsoon is accompanied with prolonged subtropical high settling over Iran's plateau that prevents the southward movement of polar jet frontal systems. Such conditions enhance northerly wind currents over the Caspian Sea which, in turn, increase the precipitation in Caspian

Groundwater flow and water budget in the surficial and Floridan aquifer systems in east-central Florida

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Sepulveda, Nicasio; Tiedeman, Claire; O'Reilly, Andrew M.; Davis, Jeffrey B.; Burger, Patrick

2012-01-01

A numerical transient model of the surficial and Floridan aquifer systems in east-central Florida was developed to (1) increase the understanding of water exchanges between the surficial and the Floridan aquifer systems, (2) assess the recharge rates to the surficial aquifer system from infiltration through the unsaturated zone and (3) obtain a simulation tool that could be used by water-resource managers to assess the impact of changes in groundwater withdrawals on spring flows and on the potentiometric surfaces of the hydrogeologic units composing the Floridan aquifer system. The hydrogeology of east-central Florida was evaluated and used to develop and calibrate the groundwater flow model, which simulates the regional fresh groundwater flow system. The U.S. Geological Survey three-dimensional groundwater flow model, MODFLOW-2005, was used to simulate transient groundwater flow in the surficial, intermediate, and Floridan aquifer systems from 1995 to 2006. The East-Central Florida Transient model encompasses an actively simulated area of about 9,000 square miles. Although the model includes surficial processes-rainfall, irrigation, evapotranspiration (ET), runoff, infiltration, lake water levels, and stream water levels and flows-its primary purpose is to characterize and refine the understanding of groundwater flow in the Floridan aquifer system. Model-independent estimates of the partitioning of rainfall into ET, streamflow, and aquifer recharge are provided from a water-budget analysis of the surficial aquifer system. The interaction of the groundwater flow system with the surface environment was simulated using the Green-Ampt infiltration method and the MODFLOW-2005 Unsaturated-Zone Flow, Lake, and Streamflow-Routing Packages. The model is intended to simulate the part of the groundwater system that contains freshwater. The bottom and lateral boundaries of the model were established at the estimated depths where the chloride concentration is 5,000 milligrams

Future Water-Supply Scenarios, Cape May County, New Jersey, 2003-2050

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Lacombe, Pierre J.; Carleton, Glen B.; Pope, Daryll A.; Rice, Donald E.

2009-01-01

Vertical Datum of 1988 (NAVD 88).] Future scenarios 4 to 9 represent withdrawals and the effects on the water supply while using estimated full build-out water demands. In most townships, existing wells would be used for withdrawals in the simulation. However, in Lower and Middle Townships, the Wildwoods, and the Cape Mays, withdrawals from some wells would be terminated, reduced, or increased. Depending on the scenario, proposed production wells would be installed in locations far from the saltwater fronts, in deep freshwater aquifers, in deeper saltwater aquifers, or proposed injection wells would be installed to inject reused water to create a freshwater barrier to saltwater intrusion. Simulations indicate that future Scenarios 4 to 9 would reduce many of the adverse effects of Scenarios 1, 2, and 3. No future scenario will minimize all adverse impacts. In Scenario 4, Lower Township would drill two production wells in the Cohansey aquifer farther from the Delaware shoreline than existing wells and reduce withdrawals from wells near the shoreline. Wildwood Water Utility (WWU) would reduce withdrawals from existing wells in the Cohansey aquifer and increase withdrawals from wells in the Rio Grande water-bearing zone. Results of the simulation indicate that saltwater intrusion and ecological-water supply problems would be reduced but not as much as in Scenarios 5, 7, 8, and 9. In Scenario 5, the Wildwoods and Lower Township each would install a desalination plant and drill two wells to withdraw saltwater from the Atlantic City 800-foot sand. Saltwater intrusion problems would be reduced to the greatest extent with this scenario. Ecological water supplies remain constant or decline from 2003 baseline values. Water-level altitudes would decline to -193 ft in the Atlantic City 800-foot sand, the deepest potentiometric level for all scenarios. In Scenario 6, Lower Township would build a tertiary treatment system and drill three wells open to the Cohanse

19 CFR 144.38 - Withdrawal for consumption.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Withdrawal for consumption. 144.38 Section 144.38... Withdrawal for consumption. (a) Form. Withdrawals for consumption of merchandise in bonded warehouses shall... considered a withdrawal for consumption pursuant to § 181.53 of this chapter. (c) Information to be shown on...

The Role of Science in Managed Aquifer Recharge--the Equus Beds aquifer near Wichita, Kansas Andrew Ziegler, Director Brian Kelly, Office Chief Michael Jacobs, Manager of Water Planning and Production Debra Ary, Engineer, Water Systems Planning (Invited)

Science.gov (United States)

Ziegler, A. C.; Jacobs, M.; Ary, D.; Kelly, B.

2013-12-01

, and groundwater identified indicator bacteria, atrazine, chloride, sodium, nitrate, arsenic, iron, and manganese as constituents of concern exceeding water-quality criteria in baseline samples. Techniques were developed to estimate Little Arkansas River water quality in real-time for treatment. Geochemical modeling using PHREEQC and PHAST shows that groundwater quality is not changed if groundwater and recharge water are of similar redox potential. If different, calcite or metal hydroxides may precipitate and decrease water infiltration. A network of 38 locations with shallow and deep wells characterizes the recharge quantities and qualities for the city of Wichita to withdraw when needed from storage. Through 2013, the Demonstration project and Phase 1 and 2 facilities (capacity 40 MGD) have artificially recharged about 2 billion gallons. Total construction costs are about $300,000,000. Data-collection, interpretative geochemical and numerical simulations and water-quality transport modeling tools developed in the past 70 years are a scientific foundation to effectively and objectively manage this aquifer system.

Water use for electricity in the United States: an analysis of reported and calculated water use information for 2008

International Nuclear Information System (INIS)

Averyt, K; Meldrum, J; Macknick, J; Newmark, R; Rogers, J; Madden, N; Fisher, J

2013-01-01

Water use by the electricity sector represents a significant portion of the United States water budget (41% of total freshwater withdrawals; 3% consumed). Sustainable management of water resources necessitates an accurate accounting of all water demands, including water use for generation of electricity. Since 1985, the Department of Energy (DOE) Energy Information Administration (EIA) has collected self-reported data on water consumption and withdrawals from individual power generators. These data represent the only annual collection of water consumption and withdrawals by the electricity sector. Here, we compile publically available information into a comprehensive database and then calculate water withdrawals and consumptive use for power plants in the US. In effect, we evaluate the quality of water use data reported by EIA for the year 2008. Significant differences between reported and calculated water data are evident, yet no consistent reason for the discrepancies emerges. (letter)

Method and system for formation and withdrawal of a sample from a surface to be analyzed

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Van Berkel, Gary J.; Kertesz, Vilmos

2017-10-03

A method and system for formation and withdrawal of a sample from a surface to be analyzed utilizes a collection instrument having a port through which a liquid solution is conducted onto the surface to be analyzed. The port is positioned adjacent the surface to be analyzed, and the liquid solution is conducted onto the surface through the port so that the liquid solution conducted onto the surface interacts with material comprising the surface. An amount of material is thereafter withdrawn from the surface. Pressure control can be utilized to manipulate the solution balance at the surface to thereby control the withdrawal of the amount of material from the surface. Furthermore, such pressure control can be coordinated with the movement of the surface relative to the port of the collection instrument within the X-Y plane.

Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast).

Science.gov (United States)

Hutchinson, Mark R; Lewis, Susannah S; Coats, Benjamen D; Skyba, David A; Crysdale, Nicole Y; Berkelhammer, Debra L; Brzeski, Anita; Northcutt, Alexis; Vietz, Christine M; Judd, Charles M; Maier, Steven F; Watkins, Linda R; Johnson, Kirk W

2009-02-01

Morphine-induced glial proinflammatory responses have been documented to contribute to tolerance to opioid analgesia. Here, we examined whether drugs previously shown to suppress glial proinflammatory responses can alter other clinically relevant opioid effects; namely, withdrawal or acute analgesia. AV411 (ibudilast) and minocycline, drugs with distinct mechanisms of action that result in attenuation of glial proinflammatory responses, each reduced naloxone-precipitated withdrawal. Analysis of brain nuclei associated with opioid withdrawal revealed that morphine altered expression of glial activation markers, cytokines, chemokines, and a neurotrophic factor. AV411 attenuated many of these morphine-induced effects. AV411 also protected against spontaneous withdrawal-induced hyperactivity and weight loss recorded across a 12-day timecourse. Notably, in the spontaneous withdrawal study, AV411 treatment was delayed relative to the start of the morphine regimen so to also test whether AV411 could still be effective in the face of established morphine dependence, which it was. AV411 did not simply attenuate all opioid effects, as co-administering AV411 with morphine or oxycodone caused three-to-five-fold increases in acute analgesic potency, as revealed by leftward shifts in the analgesic dose response curves. Timecourse analyses revealed that plasma morphine levels were not altered by AV411, suggestive that potentiated analgesia was not simply due to prolongation of morphine exposure or increased plasma concentrations. These data support and extend similar potentiation of acute opioid analgesia by minocycline, again providing converging lines of evidence of glial involvement. Hence, suppression of glial proinflammatory responses can significantly reduce opioid withdrawal, while improving analgesia.

In-Situ Measurements of the Performance of Thermosyphon Solar Water Heating Systems in Libya

International Nuclear Information System (INIS)

Abdunnabi, M. I. R.; Loveday, D. L.

2014-01-01

This paper reports on a project carried out by the Centre for Solar Energy Research and Studies (CSERS) to familiarize Libyan people with solar water heating technologies. Around 100 solar water heaters have been installed in the domestic sector and selected systems were equipped with monitoring instruments required to evaluate thermal performance. The paper presents the results of data collected over a one year period from a system installed in a family residence situated in a village located 90 km south of Tripoli (Libyan capital). The results showed that the system solar fraction was 55.8% of the average amount of daily hot water withdrawn (144 liters) at an average withdrawal temperature of 46.6 °. The total energy withdrawn during the whole year was 1557 kWl1. It is concluded that such a system is not adequate in terms of cost effectiveness for the current installed situation. It is recommended that the annual solar fraction for any solar water heating system should be over 70° in order to achieve cost—effectiveness and to help wide spread take—up of this technology.(author)

Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus.

Directory of Open Access Journals (Sweden)

M Julia García-Fuster

Full Text Available Relapse, even following an extended period of withdrawal, is a major challenge in substance abuse management. Delayed neurobiological effects of the drug during prolonged withdrawal likely contribute to sustained vulnerability to relapse. Stress is a major trigger of relapse, and the hippocampus regulates the magnitude and duration of stress responses. Recent work has implicated hippocampal plasticity in various aspects of substance abuse. We asked whether changes in stress regulatory mechanisms in the hippocampus may participate in the neuroadaptations that occur during prolonged withdrawal. We therefore examined changes in the rat stress system during the course of withdrawal from extended daily access (5-hours of cocaine self-administration, an animal model of addiction. Tissue was collected at 1, 14 and 28 days of withdrawal. Plasma corticosterone levels were determined and corticosteroid receptors (GR, MR, MR/GR mRNA ratios and expression of other stress-related molecules (HSP90AA1 and HSP90AB1 mRNA were measured in hippocampal subfields using in situ hybridization. Results showed a delayed emergence of dysregulation of stress genes in the posterior hippocampus following 28 days of cocaine withdrawal. This included increased GR mRNA in DG and CA3, increased MR and HSP90AA1 mRNA in DG, and decreased MR/GR mRNA ratio in DG and CA1. Corticosterone levels progressively decreased during the course of withdrawal, were normalized following 28 days of withdrawal, and were correlated negatively with GR and positively with MR/GR mRNA ratio in DG. These results suggest a role for the posterior hippocampus in the neuroadaptations that occur during prolonged withdrawal, and point to a signaling partner of GR, HSP90AA1, as a novel dysregulated target during cocaine withdrawal. These delayed neurobiological effects of extended cocaine exposure likely contribute to sustained vulnerability to relapse.

Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.

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Seillier, Alexandre; Martinez, Alex A; Giuffrida, Andrea

2013-08-01

The neuronal mechanisms underlying social withdrawal, one of the core negative symptoms of schizophrenia, are not well understood. Recent studies suggest an involvement of the endocannabinoid system in the pathophysiology of schizophrenia and, in particular, of negative symptoms. We used biochemical, pharmacological, and behavioral approaches to investigate the role played by the endocannabinoid system in social withdrawal induced by sub-chronic administration of phencyclidine (PCP). Pharmacological enhancement of endocannabinoid levels via systemic administration of URB597, an inhibitor of endocannabinoid degradation, reversed social withdrawal in PCP-treated rats via stimulation of CB1 receptors, but reduced social interaction in control animals through activation of a cannabinoid/vanilloid-sensitive receptor. In addition, the potent CB agonist CP55,940 reversed PCP-induced social withdrawal in a CB₁-dependent manner, whereas pharmacological blockade of CB₁ receptors by either AM251 or SR141716 reduced the time spent in social interaction in control animals. PCP-induced social withdrawal was accompanied by a decrease of anandamide (AEA) levels in the amygdala and prefrontal cortex, and these deficits were reversed by URB597. As CB₁ receptors are predominantly expressed on GABAergic interneurons containing the anxiogenic peptide cholecystokinin (CCK), we also examined whether the PCP-induced social withdrawal resulted from deficient CB₁-mediated modulation of CCK transmission. The selective CCK2 antagonist LY225910 blocked both PCP- and AM251-induced social withdrawal, but not URB597 effect in control rats. Taken together, these findings indicate that AEA-mediated activation of CB₁ receptors is crucial for social interaction, and that PCP-induced social withdrawal results from deficient endocannabinoid transmission.

The quality of our Nation's waters: water quality in the Mississippi embayment-Texas coastal uplands aquifer system and Mississippi River Valley alluvial aquifer, south-central United States, 1994-2008

Science.gov (United States)

Kingsbury, James A.; Barlow, Jeannie R.; Katz, Brian G.; Welch, Heather L.; Tollett, Roland W.; Fahlquist, Lynne S.

2015-01-01

About 8 million people rely on groundwater from the Mississippi embayment—Texas coastal uplands aquifer system for drinking water. The Mississippi River Valley alluvial aquifer also provides drinking water for domestic use in rural areas but is of primary importance to the region as a source of water for irrigation. Irrigation withdrawals from this aquifer are among the largest in the Nation and play a key role in the economy of the area, where annual crop sales total more than $7 billion. The reliance of the region on both aquifers for drinking water and irrigation highlights the importance of long-term management to sustain the availability and quality of these resources.

Anticonvulsants for alcohol withdrawal.

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Minozzi, Silvia; Amato, Laura; Vecchi, Simona; Davoli, Marina

2010-03-17

Alcohol abuse and dependence represents a most serious health problem worldwide with major social, interpersonal and legal interpolations. Besides benzodiazepines, anticonvulsants are often used for the treatment of alcohol withdrawal symptoms. Anticonvulsants drugs are indicated for the treatment of alcohol withdrawal syndrome, alone or in combination with benzodiazepine treatments. In spite of the wide use, the exact role of the anticonvulsants for the treatment of alcohol withdrawal has not yet bee adequately assessed. To evaluate the effectiveness and safety of anticonvulsants in the treatment of alcohol withdrawal. We searched Cochrane Drugs and Alcohol Group' Register of Trials (December 2009), PubMed, EMBASE, CINAHL (1966 to December 2009), EconLIT (1969 to December 2009). Parallel searches on web sites of health technology assessment and related agencies, and their databases. Randomized controlled trials (RCTs) examining the effectiveness, safety and overall risk-benefit of anticonvulsants in comparison with a placebo or other pharmacological treatment. All patients were included regardless of age, gender, nationality, and outpatient or inpatient therapy. Two authors independently screened and extracted data from studies. Fifty-six studies, with a total of 4076 participants, met the inclusion criteria. Comparing anticonvulsants with placebo, no statistically significant differences for the six outcomes considered.Comparing anticonvulsant versus other drug, 19 outcomes considered, results favour anticonvulsants only in the comparison carbamazepine versus benzodiazepine (oxazepam and lorazepam) for alcohol withdrawal symptoms (CIWA-Ar score): 3 studies, 262 participants, MD -1.04 (-1.89 to -0.20), none of the other comparisons reached statistical significance.Comparing different anticonvulsants no statistically significant differences in the two outcomes considered.Comparing anticonvulsants plus other drugs versus other drugs (3 outcomes considered), results

MITS Feed and Withdrawal Subsystem: operating procedures

International Nuclear Information System (INIS)

Brown, W.S.

1980-01-01

This procedure details the steps involved in filling two of the four MITS (Machine Interface Test System) Feed and Withdrawal subsystem main traps and the Sample/Inventory Make-up Pipette with uranium hexafluoride from the ''AS RECEIVED'' UF 6 supply

Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal.

Science.gov (United States)

Scavone, J L; Sterling, R C; Van Bockstaele, E J

2013-09-17

Withdrawal from opiates, such as heroin or oral narcotics, is characterized by a host of aversive physical and emotional symptoms. High rates of relapse and limited treatment success rates for opiate addiction have prompted a search for new approaches. For many opiate addicts, achieving abstinence may be further complicated by poly-drug use and co-morbid mental disorders. Research over the past decade has shed light on the influence of endocannabinoids (ECs) on the opioid system. Evidence from both animal and clinical studies point toward an interaction between these two systems, and suggest that targeting the EC system may provide novel interventions for managing opiate dependence and withdrawal. This review will summarize the literature surrounding the molecular effects of cannabinoids and opioids on the locus coeruleus-norepinephrine system, a key circuit implicated in the negative sequelae of opiate addiction. A consideration of the trends and effects of marijuana use in those seeking treatment to abstain from opiates in the clinical setting will also be presented. In summary, the present review details how cannabinoid-opioid interactions may inform novel interventions in the management of opiate dependence and withdrawal. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

Data model and relational database design for the New Jersey Water-Transfer Data System (NJWaTr)

Science.gov (United States)

Tessler, Steven

2003-01-01

The New Jersey Water-Transfer Data System (NJWaTr) is a database design for the storage and retrieval of water-use data. NJWaTr can manage data encompassing many facets of water use, including (1) the tracking of various types of water-use activities (withdrawals, returns, transfers, distributions, consumptive-use, wastewater collection, and treatment); (2) the storage of descriptions, classifications and locations of places and organizations involved in water-use activities; (3) the storage of details about measured or estimated volumes of water associated with water-use activities; and (4) the storage of information about data sources and water resources associated with water use. In NJWaTr, each water transfer occurs unidirectionally between two site objects, and the sites and conveyances form a water network. The core entities in the NJWaTr model are site, conveyance, transfer/volume, location, and owner. Other important entities include water resource (used for withdrawals and returns), data source, permit, and alias. Multiple water-exchange estimates based on different methods or data sources can be stored for individual transfers. Storage of user-defined details is accommodated for several of the main entities. Many tables contain classification terms to facilitate the detailed description of data items and can be used for routine or custom data summarization. NJWaTr accommodates single-user and aggregate-user water-use data, can be used for large or small water-network projects, and is available as a stand-alone Microsoft? Access database. Data stored in the NJWaTr structure can be retrieved in user-defined combinations to serve visualization and analytical applications. Users can customize and extend the database, link it to other databases, or implement the design in other relational database applications.

Perinatal risk factors and social withdrawal behaviour.

Science.gov (United States)

Guedeney, Antoine; Marchand-Martin, Laetitia; Cote, Sylvana J; Larroque, Béatrice

2012-04-01

The objectives of the study were (1) to assess prevalence of social withdrawal behaviour in infants aged 12 months included in the French Perinatal Risk Factor Study Eden; (2) To study the correlation between relational withdrawal and several perinatal and parental factors assessed in the EDEN study. A longitudinal study using the ADBB scale was conducted within the Eden Cohort in the year 2008. 1,586 infants were included in the study. Fourteen percent of the children who had an ADBB assessment had a score at 5 and over on the ADBB, a scale designed to assess social withdrawal behaviour at age 0-24 months. Social withdrawal at 12 months was associated with low birth weight, low gestational age and with intra uterine growth retardation. Social withdrawal was independently associated with several maternal and paternal risk factors. The level of social withdrawal behaviour increased with a score of maternal difficulties. This study on a large longitudinally followed volunteer sample demonstrate a clear association of social withdrawal behaviour at age one with low birth weight and preterm birth, possibly mediated by parental vulnerabilities. Social withdrawal behaviour seems to be an important alarm signal to detect early on particularly in premature and small for date babies. © Springer-Verlag 2012

Clinical management of alcohol withdrawal: A systematic review

Directory of Open Access Journals (Sweden)

Shivanand Kattimani

2013-01-01

Full Text Available Alcohol withdrawal is commonly encountered in general hospital settings. It forms a major part of referrals received by a consultation-liaison psychiatrist. This article aims to review the evidence base for appropriate clinical management of the alcohol withdrawal syndrome. We searched Pubmed for articles published in English on pharmacological management of alcohol withdrawal in humans with no limit on the date of publication. Articles not relevant to clinical management were excluded based on the titles and abstract available. Full-text articles were obtained from this list and the cross-references. There were four meta-analyses, 9 systematic reviews, 26 review articles and other type of publications like textbooks. Alcohol withdrawal syndrome is a clinical diagnosis. It may vary in severity. Complicated alcohol withdrawal presents with hallucinations, seizures or delirium tremens. Benzodiazepines have the best evidence base in the treatment of alcohol withdrawal, followed by anticonvulsants. Clinical institutes withdrawal assessment-alcohol revised is useful with pitfalls in patients with medical comorbidities. Evidence favors an approach of symptom-monitored loading for severe withdrawals where an initial dose is guided by risk factors for complicated withdrawals and further dosing may be guided by withdrawal severity. Supportive care and use of vitamins is also discussed.

Experimental and numerical study of heat transfer phenomena, inside a flat-plate integrated collector storage solar water heater (ICSSWH), with indirect heat withdrawal

International Nuclear Information System (INIS)

Gertzos, K.P.; Pnevmatikakis, S.E.; Caouris, Y.G.

2008-01-01

The thermal behavior of a particular flat-plate integrated collector storage solar water heater (ICSSWH) is examined, experimentally and numerically. The particularity consists of the indirect heating of the service hot water, through a heat exchanger incorporated into front and back major surfaces of the ICSSWH. Natural and forced convection mechanisms are both examined. A prototype tank was fabricated and experimental data of temperature profiles are extracted, during various energy withdrawals. A 3D computational fluid dynamics (CFD) model was developed and validated against experimental results. Numerical predictions are found highly accurate, providing thus the use of the 3D CFD model for the optimization of this and similar devices

Water reuse in river basins with multiple users: A literature review

Science.gov (United States)

Simons, G. W. H. (Gijs); Bastiaanssen, W. G. M. (Wim); Immerzeel, W. W. (Walter)

2015-03-01

Unraveling the interaction between water users in a river basin is essential for sound water resources management, particularly in a context of increasing water scarcity and the need to save water. While most attention from managers and decision makers goes to allocation and withdrawals of surface water resources, reuse of non-consumed water gets only marginal attention despite the potentially significant volumes. As a consequence, claims of water saving are often grossly exaggerated. It is the purpose of this paper to explore the processes associated with water reuse in a river basin among users of varying nature and review existing methods for directly or indirectly describing non-consumed water, recoverable flow and/or water reuse. First a conceptual representation of processes surrounding water withdrawals and associated definitions is discussed, followed by a section on connectivity between individual withdrawals and the complex dynamics arising from dependencies and tradeoffs within a river basin. The current state-of-the-art in categorizing basin hydrological flows is summarized and its applicability to a water system where reuse occurs is explored. The core of the paper focuses on a selection and demonstration of existing indicators developed for assessing water reuse and its impacts. It is concluded that although several methods for analyses of water reuse and recoverable flows have been developed, a number of essential aspects of water reuse are left out of existing indicators. Moreover, a proven methodology for obtaining crucial quantitative information on recoverable flows is currently lacking. Future studies should aim at spatiotemporal tracking of the recoverable portion of water withdrawals and showing the dependency of multiple water users on such flows to water policy makers.

Estimated Use of Water in the United States in 1985

Science.gov (United States)

Solley, Wayne B.; Merk, Charles F.; Pierce, Robert R.

1988-01-01

Water withdrawals in the United States during 1985 were estimated to average 399,000 million gallons per day (Mgal/d) of freshwater and saline water for offstream uses--10 percent less than the 1980 estimate. Average per-capita use for all offstream uses was 1,650 gallons per day (gal/d) of freshwater and saline water combined and 1,400 gal/d of freshwater alone. Offstream water-use categories are classified in this report as public supply, domestic, commercial, irrigation, livestock, industrial, mining, and thermoelectric power. During 1985, public-supply withdrawals were estimated to be 36,500 Mgal/d, and self-supplied withdrawals were estimated as follows: domestic, 3,320 Mgal/d: commercial, 1,230 Mgal/d; irrigation, 137,000 Mgal/d: livestock, 4,470 Mgal/d; industrial, 25,800 Mgal/d; mining, 3,440 Mgal/d; and thermoelectric power, 187,000 Mgal/d. Water use for hydroelectric power generation, the only instream use compiled in this report, was estimated to be 3,050,000 Mgal/d during 1985, or 7 percent less than during 1980. This is in contrast to an increasing trend that persisted from 1950 to 1980. Estimates of withdrawals by source indicate that, during 1985, total surface-water withdrawals were 325,000 Mgal/d, or 10 percent less than during 1980, and total ground-water withdrawals were 74,000 Mgal/d, or 12 percent less than during 1980. Total saline-water withdrawals during 1985 were 60,300 Mgal/d, or 16 percent less than during 1980; most was saline surface water. Reclaimed sewage averaged about 579 Mgal/d during 1985, or 22 percent more than during 1980. Total freshwater consumptive use was estimated to be 92,300 Mgal/d during 1985, or 9 percent less than during 1980. Consumptive use by irrigation accounted for the largest part of consumptive use during 1985 and was estimated to be 73,800 Mgal/d. A comparison of total withdrawals (fresh and saline) by State indicates that 37 States and Puerto Rico had less water withdrawn for offstream uses during 1985 than

Prediction of withdrawal symptoms during opioid detoxification

NARCIS (Netherlands)

Dijkstra, Boukje A G; Krabbe, Paul F M; De Jong, Cor A J; van der Staak, Cees P F

2008-01-01

OBJECTIVE: The severity of self-reported withdrawal symptoms varies during detoxification of opioid-dependent patients. The aim of this study is to identify subgroups of withdrawal symptoms within the detoxification trajectory and to predict the severity of withdrawal symptoms on the basis of

Prediction of withdrawal symptoms during opioid detoxification

NARCIS (Netherlands)

Dijkstra, B.A.G.; Krabbe, P.F.M.; Jong, C.A.J. de; Staak, C.P.F. van der

2008-01-01

Objective: The severity of self-reported withdrawal symptoms varies during detoxification of opioid-dependent patients. The aim of this study is to identify subgroups of withdrawal symptoms within the detoxification trajectory and to predict the severity of withdrawal symptoms on the basis of

Estimated use of water in Alabama in 2005

Science.gov (United States)

Hutson, Susan S.; Littlepage, Thomas M.; Harper, Michael J.; Tinney, James O.

2009-01-01

Water use in Alabama was about 9,958 million gallons per day (Mgal/d) during 2005. Estimates of withdrawals by source indicate that total surface-water withdrawals were about 9,467 Mgal/d (95 percent of the total withdrawals) and the remaining 491 Mgal/d (5 percent) were from ground water. More surface water than ground water was withdrawn for all categories except aquaculture, mining, and self-supplied residential. During 2005, estimated withdrawals by category and in descending order were: thermoelectric power, 8,274 Mgal/d; public supply, 802 Mgal/d; self-supplied industrial, 550 Mgal/d; irrigation, 161 Mgal/d; aquaculture, 75 Mgal/d; self-supplied residential, 39 Mgal/d; livestock, 28 Mgal/d; and mining, 28 Mgal/d.

78 FR 58555 - Public Land Order No. 7821; Withdrawal of National Forest System Land for Steamboat Rock Picnic...

Science.gov (United States)

2013-09-24

...; Withdrawal of National Forest System Land for Steamboat Rock Picnic Grounds; South Dakota AGENCY: Bureau of... the Steamboat Rock Picnic Grounds within the Black Hills National Forest in South Dakota. DATES... Steamboat Rock Picnic Grounds. Order By virtue of the authority vested in the Secretary of the Interior by...

Guidelines for preparation of State water-use estimates for 2015

Science.gov (United States)

Bradley, Michael W.

2017-05-01

The U.S. Geological Survey (USGS) has estimated the use of water in the United States at 5-year intervals since 1950. This report describes the water-use categories and data elements used for the national water-use compilation conducted as part of the USGS National Water-Use Science Project. The report identifies sources of water-use information, provides standard methods and techniques for estimating water use at the county level, and outlines steps for preparing documentation for the United States, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands.As part of this USGS program to document water use on a national scale, estimates of water withdrawals for the categories of public supply, self-supplied domestic, industrial, irrigation, and thermoelectric power are prepared for each county in each State, District, or territory by using the guidelines in this report. County estimates of water withdrawals for aquaculture, livestock, and mining are prepared for each State by using a county-based national model, although water-use programs in each State or Water Science Center have the option of producing independent county estimates of water withdrawals for these categories. Estimates of water withdrawals and consumptive use for thermoelectric power will be aggregated to the county level for each State by the national project; additionally, irrigation consumptive use at the county level will also be provided, although study chiefs in each State have the option of producing independent county estimates of water withdrawals and consumptive use for these categories.Estimates of deliveries of water from public supplies for domestic use by county also will be prepared for each State. As a result, total domestic water use can be determined for each State by combining self-supplied domestic withdrawals and public-supplied domestic deliveries. Fresh groundwater and surface-water estimates will be prepared for all categories of use, and saline groundwater and

Control rod excess withdrawal prevention device

International Nuclear Information System (INIS)

Takayama, Yoshihito.

1992-01-01

Excess withdrawal of a control rod of a BWR type reactor is prevented. That is, the device comprises (1) a speed detector for detecting the driving speed of a control rod, (2) a judging circuit for outputting an abnormal signal if the driving speed is greater than a predetermined level and (3) a direction control valve compulsory closing circuit for controlling the driving direction of inserting and withdrawing a control rod based on an abnormal signal. With such a constitution, when the with drawing speed of a control rod is greater than a predetermined level, it is detected by the speed detector and the judging circuit. Then, all of the direction control valve are closed by way of the direction control valve compulsory closing circuit. As a result, the operation of the control rod is stopped compulsorily and the withdrawing speed of the control rod can be lowered to a speed corresponding to that upon gravitational withdrawal. Accordingly, excess withdrawal can be prevented. (I.S)

19 CFR 144.37 - Withdrawal for exportation.

Science.gov (United States)

2010-04-01

...) Class 9 warehouse withdrawals for exportation—(1) Applicability of sales ticket procedure. Merchandise... be eligible for withdrawal under the sales ticket procedure specified in this paragraph. (2) Sales ticket content and handling. Sales ticket withdrawals must be made only under a blanket permit to...

5 CFR 362.207 - Withdrawal and readmission.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Withdrawal and readmission. 362.207... PRESIDENTIAL MANAGEMENT FELLOWS PROGRAM Program Administration § 362.207 Withdrawal and readmission. (a...) An agency must notify OPM when a Fellow or Senior Fellow withdraws from the Program. (b) Readmission...

Opioid withdrawal suppression efficacy of oral dronabinol in opioid dependent humans.

Science.gov (United States)

Lofwall, Michelle R; Babalonis, Shanna; Nuzzo, Paul A; Elayi, Samy Claude; Walsh, Sharon L

2016-07-01

The cannabinoid (CB) system is a rational novel target for treating opioid dependence, a significant public health problem around the world. This proof-of-concept study examined the potential efficacy of a CB1 receptor partial agonist, dronabinol, in relieving signs and symptoms of opioid withdrawal. Twelve opioid dependent adults participated in this 5-week, inpatient, double-blind, randomized, placebo-controlled study. Volunteers were maintained on double-blind oxycodone (30mg oral, four times/day) and participated in a training session followed by 7 experimental sessions, each testing a single oral test dose (placebo, oxycodone 30 and 60mg, dronabinol 5, 10, 20, and 30mg [decreased from 40mg]). Placebo was substituted for oxycodone maintenance doses for 21h before each session in order to produce measurable opioid withdrawal. Outcomes included observer- and participant-ratings of opioid agonist, opioid withdrawal and psychomotor/cognitive performance. Oxycodone produced prototypic opioid agonist effects (i.e. suppressing withdrawal and increasing subjective effects indicative of abuse liability). Dronabinol 5 and 10mg produced effects most similar to placebo, while the 20 and 30mg doses produced modest signals of withdrawal suppression that were accompanied by dose-related increases in high, sedation, bad effects, feelings of heart racing, and tachycardia. Dronabinol was not liked more than placebo, showed some impairment in cognitive performance, and was identified as marijuana with increasing dose. CB1 receptor activation is a reasonable strategy to pursue for the treatment of opioid withdrawal; however, dronabinol is not a likely candidate given its modest withdrawal suppression effects of limited duration and previously reported tachycardia during opioid withdrawal. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Tobacco withdrawal among opioid-dependent smokers.

Science.gov (United States)

Streck, Joanna M; Heil, Sarah H; Higgins, Stephen T; Bunn, Janice Y; Sigmon, Stacey C

2018-04-01

Prevalence of cigarette smoking among opioid-dependent individuals is 6-fold that of the general U.S. adult population and their quit rates are notoriously poor. One possible reason for the modest cessation outcomes in opioid-dependent smokers may be that they experience more severe tobacco withdrawal upon quitting. In this secondary analysis, we evaluated tobacco withdrawal in opioid-dependent (OD) smokers versus smokers without co-occurring substance use disorders (SUDs). Participants were 47 methadone- or buprenorphine-maintained smokers and 25 non-SUD smokers who completed 1 of several 2-week studies involving daily visits for biochemical monitoring, delivery of financial incentives contingent on smoking abstinence, and assessment of withdrawal via the Minnesota Nicotine Withdrawal Scale (MNWS). Prior to quitting smoking, OD smokers presented with higher baseline withdrawal scores than non-SUD smokers (1.7 ± 0.2 vs. 0.7 ± 0.2, respectively; F [1, 63] = 7.31, p non-SUD smokers, suggesting that elevated withdrawal severity following quitting may not be a major factor contributing to the poor cessation outcomes consistently observed among OD smokers. Further scientific efforts are needed to improve our understanding of the high smoking rates and modest cessation outcomes in this challenging population. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

77 FR 8895 - Public Land Order No. 7788; Withdrawal of National Forest System Land for the Red Cloud...

Science.gov (United States)

2012-02-15

... Land Order No. 7788; Withdrawal of National Forest System Land for the Red Cloud Campground; New Mexico... Cloud Campground within the Cibola National Forest, and to protect a capital investment in the... (FIRS) at 1-800-877-8339 to contact either of the above individuals during normal business hours. The...

The benzodiazepine withdrawal syndrome and its management.

OpenAIRE

Onyett, S R

1989-01-01

The literature on benzodiazepine dependence and withdrawal is reviewed with an emphasis on social and psychological considerations. The problems of when to prescribe, identifying withdrawal symptoms, effective communication with the patient, the structure of withdrawal programmes, and the use of drugs, psychological approaches and other services are discussed.

47 CFR 1.8 - Withdrawal of papers.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Withdrawal of papers. 1.8 Section 1.8 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE General Rules of Practice and Procedure General § 1.8 Withdrawal of papers. The granting of a request to dismiss or withdraw an...

29 CFR 102.104 - Withdrawal of petition.

Science.gov (United States)

2010-07-01

... 29 Labor 2 2010-07-01 2010-07-01 false Withdrawal of petition. 102.104 Section 102.104 Labor... Orders and Advisory Opinions Regarding Board Jurisdiction § 102.104 Withdrawal of petition. The petitioner may withdraw his petition at any time prior to issuance of the Board's advisory opinion. ...

Quantifying the Clinical Significance of Cannabis Withdrawal

Science.gov (United States)

Allsop, David J.; Copeland, Jan; Norberg, Melissa M.; Fu, Shanlin; Molnar, Anna; Lewis, John; Budney, Alan J.

2012-01-01

Background and Aims Questions over the clinical significance of cannabis withdrawal have hindered its inclusion as a discrete cannabis induced psychiatric condition in the Diagnostic and Statistical Manual of Mental Disorders (DSM IV). This study aims to quantify functional impairment to normal daily activities from cannabis withdrawal, and looks at the factors predicting functional impairment. In addition the study tests the influence of functional impairment from cannabis withdrawal on cannabis use during and after an abstinence attempt. Methods and Results A volunteer sample of 49 non-treatment seeking cannabis users who met DSM-IV criteria for dependence provided daily withdrawal-related functional impairment scores during a one-week baseline phase and two weeks of monitored abstinence from cannabis with a one month follow up. Functional impairment from withdrawal symptoms was strongly associated with symptom severity (p = 0.0001). Participants with more severe cannabis dependence before the abstinence attempt reported greater functional impairment from cannabis withdrawal (p = 0.03). Relapse to cannabis use during the abstinence period was associated with greater functional impairment from a subset of withdrawal symptoms in high dependence users. Higher levels of functional impairment during the abstinence attempt predicted higher levels of cannabis use at one month follow up (p = 0.001). Conclusions Cannabis withdrawal is clinically significant because it is associated with functional impairment to normal daily activities, as well as relapse to cannabis use. Sample size in the relapse group was small and the use of a non-treatment seeking population requires findings to be replicated in clinical samples. Tailoring treatments to target withdrawal symptoms contributing to functional impairment during a quit attempt may improve treatment outcomes. PMID:23049760

Quantifying the clinical significance of cannabis withdrawal.

Directory of Open Access Journals (Sweden)

David J Allsop

Full Text Available Questions over the clinical significance of cannabis withdrawal have hindered its inclusion as a discrete cannabis induced psychiatric condition in the Diagnostic and Statistical Manual of Mental Disorders (DSM IV. This study aims to quantify functional impairment to normal daily activities from cannabis withdrawal, and looks at the factors predicting functional impairment. In addition the study tests the influence of functional impairment from cannabis withdrawal on cannabis use during and after an abstinence attempt.A volunteer sample of 49 non-treatment seeking cannabis users who met DSM-IV criteria for dependence provided daily withdrawal-related functional impairment scores during a one-week baseline phase and two weeks of monitored abstinence from cannabis with a one month follow up. Functional impairment from withdrawal symptoms was strongly associated with symptom severity (p=0.0001. Participants with more severe cannabis dependence before the abstinence attempt reported greater functional impairment from cannabis withdrawal (p=0.03. Relapse to cannabis use during the abstinence period was associated with greater functional impairment from a subset of withdrawal symptoms in high dependence users. Higher levels of functional impairment during the abstinence attempt predicted higher levels of cannabis use at one month follow up (p=0.001.Cannabis withdrawal is clinically significant because it is associated with functional impairment to normal daily activities, as well as relapse to cannabis use. Sample size in the relapse group was small and the use of a non-treatment seeking population requires findings to be replicated in clinical samples. Tailoring treatments to target withdrawal symptoms contributing to functional impairment during a quit attempt may improve treatment outcomes.

Modeling and Economic Analysis of Power Grid Operations in a Water Constrained System

Science.gov (United States)

Zhou, Z.; Xia, Y.; Veselka, T.; Yan, E.; Betrie, G.; Qiu, F.

2016-12-01

The power sector is the largest water user in the United States. Depending on the cooling technology employed at a facility, steam-electric power stations withdrawal and consume large amounts of water for each megawatt hour of electricity generated. The amounts are dependent on many factors, including ambient air and water temperatures, cooling technology, etc. Water demands from most economic sectors are typically highest during summertime. For most systems, this coincides with peak electricity demand and consequently a high demand for thermal power plant cooling water. Supplies however are sometimes limited due to seasonal precipitation fluctuations including sporadic droughts that lead to water scarcity. When this occurs there is an impact on both unit commitments and the real-time dispatch. In this work, we model the cooling efficiency of several different types of thermal power generation technologies as a function of power output level and daily temperature profiles. Unit specific relationships are then integrated in a power grid operational model that minimizes total grid production cost while reliably meeting hourly loads. Grid operation is subject to power plant physical constraints, transmission limitations, water availability and environmental constraints such as power plant water exit temperature limits. The model is applied to a standard IEEE-118 bus system under various water availability scenarios. Results show that water availability has a significant impact on power grid economics.

A science plan for a comprehensive assessment of water supply in the region underlain by fractured rock in Maryland

Science.gov (United States)

Fleming, Brandon J.; Hammond, Patrick A.; Stranko, Scott A.; Duigon, Mark T.; Kasraei, Saeid

2012-01-01

The fractured rock region of Maryland, which includes land areas north and west of the Interstate 95 corridor, is the source of water supply for approximately 4.4 million Marylanders, or approximately 76 percent of the State's population. Whereas hundreds of thousands of residents rely on wells (both domestic and community), millions rely on surface-water sources. In this region, land use, geology, topography, water withdrawals, impoundments, and other factors affect water-flow characteristics. The unconfined groundwater systems are closely interconnected with rivers and streams, and are affected by seasonal and climatic variations. During droughts, groundwater levels drop, thereby decreasing well yields, and in some cases, wells have gone dry. Low ground-water levels contribute to reduced streamflows, which in turn, can lead to reduced habitat for aquatic life. Increased demand, over-allocation, population growth, and climate change can affect the future sustainability of water supplies in the region of Maryland underlain by fractured rock. In response to recommendations of the 2008 Advisory Committee on the Management and Protection of the State's Water Resources report, the Maryland Department of the Environment's Water Supply Program, the Maryland Geological Survey, the Maryland Department of Natural Resources, Monitoring and Non-Tidal Assessment (MANTA) Division, and the U.S. Geological Survey have developed a science plan for a comprehensive assessment that will provide new scientific information, new data analysis, and new tools for the State to better manage water resources in the fractured rock region of Maryland. The science plan lays out five goals for the comprehensive assessment: (1) develop tools for the improved management and investigation of groundwater and surface-water resources; (2) characterize factors affecting reliable yields of individual groundwater and surface-water supplies; (3) investigate impacts on nearby water withdrawal users caused

19 CFR 144.36 - Withdrawal for transportation.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Withdrawal for transportation. 144.36 Section 144... § 144.36 Withdrawal for transportation. (a) Time limit. Merchandise may be withdrawn from warehouse for transportation to another port of entry if withdrawal for consumption or exportation can be accomplished at the...

Real-Time System for Water Modeling and Management

Science.gov (United States)

Lee, J.; Zhao, T.; David, C. H.; Minsker, B.

2012-12-01

Working closely with the Texas Commission on Environmental Quality (TCEQ) and the University of Texas at Austin (UT-Austin), we are developing a real-time system for water modeling and management using advanced cyberinfrastructure, data integration and geospatial visualization, and numerical modeling. The state of Texas suffered a severe drought in 2011 that cost the state $7.62 billion in agricultural losses (crops and livestock). Devastating situations such as this could potentially be avoided with better water modeling and management strategies that incorporate state of the art simulation and digital data integration. The goal of the project is to prototype a near-real-time decision support system for river modeling and management in Texas that can serve as a national and international model to promote more sustainable and resilient water systems. The system uses National Weather Service current and predicted precipitation data as input to the Noah-MP Land Surface model, which forecasts runoff, soil moisture, evapotranspiration, and water table levels given land surface features. These results are then used by a river model called RAPID, along with an error model currently under development at UT-Austin, to forecast stream flows in the rivers. Model forecasts are visualized as a Web application for TCEQ decision makers, who issue water diversion (withdrawal) permits and any needed drought restrictions; permit holders; and reservoir operation managers. Users will be able to adjust model parameters to predict the impacts of alternative curtailment scenarios or weather forecasts. A real-time optimization system under development will help TCEQ to identify optimal curtailment strategies to minimize impacts on permit holders and protect health and safety. To develop the system we have implemented RAPID as a remotely-executed modeling service using the Cyberintegrator workflow system with input data downloaded from the North American Land Data Assimilation System. The

A holistic water balance of Austria - how does the quantitative proportion of urban water requirements relate to other users?

Science.gov (United States)

Vanham, D

2012-01-01

Traditional water use statistics only include the blue water withdrawal/consumption of municipalities, industry and irrigated agriculture. When, however, green water use of the agricultural sector is included as well as the virtual water use/water footprint (WF), water use quantity statistics become very different. In common water use statistics, Austria withdraws in total about 2.5 km(3) per year, only 3% of available resources (total discharge 81.4 km(3) = surface and ground water). The total water consumption (0.5 km(3)) is less than 1% of available resources. Urban (municipal) water requirements account for 27% of total withdrawal or 33% of consumption. When agricultural green water use (cropland) is included in statistics, the fraction of municipal water requirements diminishes to 7.6% of total withdrawal and 2.5% of total consumption. If the evapotranspiration of grassland and alpine meadows is also included in agricultural green water use, this fraction decreases to 3.2% and 0.9% respectively. When the WF is assessed as base value for water use in Austria, the municipal water use represents 5.8% of this value. In this globalized world, these traditional water use statistics are no longer recommendable. Only a holistic water balance approach really represents water use statistics.

The Visible Burrow System: A behavioral paradigm to assess sociability and social withdrawal in BTBR and C57BL/6J mice strains.

Science.gov (United States)

Bove, Maria; Ike, Kevin; Eldering, Adriaan; Buwalda, Bauke; de Boer, Sietse F; Morgese, Maria Grazia; Schiavone, Stefania; Cuomo, Vincenzo; Trabace, Luigia; Kas, Martien J H

2018-05-15

Disrupted sociability and consequent social withdrawal are (early) symptoms of a wide variety of neuropsychiatric diseases, such as schizophrenia, autism spectrum disorders, depressive disorders and Alzheimer's disease. The paucity of objective measures to translationally assess social withdrawal characteristics has been an important limitation to study this behavioral phenotype, both in human and rodents. The aim of the present study was to investigate sociability and social withdrawal in rodents using an ethologically valid behavioral paradigm, the Visible Burrow System (VBS). The VBS mimics a natural environment, with male and female rodents housed together in an enclosure where a large open arena is connected to a continuously dark burrow system that includes 4 nest boxes. In this study, mixed-sex colonies of C57BL/6J and of BTBR mice have been investigated (n = 8 mice per colony). Results showed marked differences between the two strains, in terms of sociability as well as social withdrawal behaviors. In particular, BTBR mice performed less social behaviors and have a preference for non-social behaviors compared to C57BL/6J mice. Neurobiologically, the decreased sociability of BTBR was accompanied by reduced GABA and increased glutamate concentrations in brain prefrontal cortex (PFC) and amygdala regions. In conclusion, our study validated the use of the VBS as an ethologically relevant behavioral paradigm in group-housed mice to investigate individual sociability and social withdrawal features and their underlying neurobiology. This paradigm may provide new insights to develop new therapeutic treatments for behavioral dysfunctions that may be relevant across neuropsychiatric diseases. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Worldwide withdrawal of medicinal products because of adverse drug reactions: a systematic review and analysis.

Science.gov (United States)

Onakpoya, Igho J; Heneghan, Carl J; Aronson, Jeffrey K

2016-07-01

We have systematically identified medicinal products withdrawn worldwide because of adverse drug reactions, assessed the level of evidence used for making the withdrawal decisions, and explored the patterns of withdrawals over time. We searched PubMed, the WHO database of withdrawn products, and selected texts. We included products that were withdrawn after launch from 1950 onwards, excluding non-human and over-the-counter medicines. We assessed the levels of evidence on which withdrawals were based using the Oxford Center for Evidence Based Medicine Levels of Evidence. Of 353 medicinal products withdrawn from any country, only 40 were withdrawn worldwide. Anecdotal reports were cited as evidence for withdrawal in 30 (75%) and deaths occurred in 27 (68%). Hepatic, cardiac, and nervous system toxicity accounted for over 60% of withdrawals. In 28 cases, the first withdrawal was initiated by the manufacturer. The median interval between the first report of an adverse drug reaction that led to withdrawal and the first withdrawal was 1 year (range 0-43 years). Worldwide withdrawals occurred within 1 year after the first withdrawal in any country. In conclusion, the time it takes for drugs to be withdrawn worldwide after reports of adverse drug reactions has shortened over time. However, there are inconsistencies in current withdrawal procedures when adverse drug reactions are suspected. A uniform method for establishing worldwide withdrawal of approved medicinal products when adverse drug reactions are suspected should be developed, to facilitate global withdrawals. Rapid synthesis of the evidence on harms should be a priority when serious adverse reactions are suspected.

Estimated use of water in the United States in 1970

Science.gov (United States)

Murray, Charles Richard; Reeves, E. Bodette

1972-01-01

Estimates of water use in the United States in 1970 indicate that an average of about 370 bgd (billion gallons per day)about 1,800 gallons per capita per day--was withdrawn for the four principal off-channel uses which are (1) public-supply (for domestic, commercial, and industrial uses), (2) rural (domestic and livestock), (3) irrigation, and (4) self-supplied industrial (including thermoelectric power). In 1970, withdrawals for these uses exceeded by 19 percent the 310 bgd estimated for 1965. Increases in the various categories of off-channel water use since 1965 were: approximately 25 percent for self-supplied industry (mainly in electric-utility thermoelectric plants), 13 percent for public supplies, 13 percent for rural supplies, and 8 percent for irrigation. Industrial water withdrawals included 54 bgd of saline water, a 20 percent increase in 5 years. The fifth principal withdrawal use, hydroelectric power (an in-channel use), amounted to 2,800 bgd, a 5-year increase of 22 percent. In computing total withdrawals, recycling within a plant (reuse) is not counted, but withdrawal of the same water by a downstream user (cumulative withdrawals) is counted. The quantity of fresh water consumed--that is, water made unavailable for further possible withdrawal because of evaporation, incorporation in crops and manufactured products, and other causes--was estimated to average 87 bgd for 1970, an increase of about 12 percent since 1965.

Psychosis following Tramadol Withdrawal

OpenAIRE

Rajabizadeh, Ghodratolah; Kheradmand, Ali; Nasirian, Mansoureh

2009-01-01

Background: Tramadol is a centrally acting opioid analgesic used to treat moderate to sever pain. It has more advantage and less opioid adverse effects than conventional opioid analgesia. Case Report: This article reports a patient with tramadol dependency that had psychosis after tramadol withdrawal. Conclusion: By the increase of tramadol usage for relief of chronic pain, tramadol abuse and dependency is increased. Some of tramadol withdrawal symptoms are not related to opioid, for example ...

Phencyclidine-Induced Social Withdrawal Results from Deficient Stimulation of Cannabinoid CB1 Receptors: Implications for Schizophrenia

Science.gov (United States)

Seillier, Alexandre; Martinez, Alex A; Giuffrida, Andrea

2013-01-01

The neuronal mechanisms underlying social withdrawal, one of the core negative symptoms of schizophrenia, are not well understood. Recent studies suggest an involvement of the endocannabinoid system in the pathophysiology of schizophrenia and, in particular, of negative symptoms. We used biochemical, pharmacological, and behavioral approaches to investigate the role played by the endocannabinoid system in social withdrawal induced by sub-chronic administration of phencyclidine (PCP). Pharmacological enhancement of endocannabinoid levels via systemic administration of URB597, an inhibitor of endocannabinoid degradation, reversed social withdrawal in PCP-treated rats via stimulation of CB1 receptors, but reduced social interaction in control animals through activation of a cannabinoid/vanilloid-sensitive receptor. In addition, the potent CB agonist CP55,940 reversed PCP-induced social withdrawal in a CB1-dependent manner, whereas pharmacological blockade of CB1 receptors by either AM251 or SR141716 reduced the time spent in social interaction in control animals. PCP-induced social withdrawal was accompanied by a decrease of anandamide (AEA) levels in the amygdala and prefrontal cortex, and these deficits were reversed by URB597. As CB1 receptors are predominantly expressed on GABAergic interneurons containing the anxiogenic peptide cholecystokinin (CCK), we also examined whether the PCP-induced social withdrawal resulted from deficient CB1-mediated modulation of CCK transmission. The selective CCK2 antagonist LY225910 blocked both PCP- and AM251-induced social withdrawal, but not URB597 effect in control rats. Taken together, these findings indicate that AEA-mediated activation of CB1 receptors is crucial for social interaction, and that PCP-induced social withdrawal results from deficient endocannabinoid transmission. PMID:23563893

Life cycle assessment of water supply alternatives in water-receiving areas of the South-to-North Water Diversion Project in China.

Science.gov (United States)

Li, Yi; Xiong, Wei; Zhang, Wenlong; Wang, Chao; Wang, Peifang

2016-02-01

To alleviate the water shortage in northern China, the Chinese government launched the world's largest water diversion project, the South-to-North Water Diversion Project (SNWDP), which delivers water from water-sufficient southern China to water-deficient northern China. However, an up-to-date study has not been conducted to determine whether the project is a favorable option to augment the water supply from an environmental perspective. The life cycle assessment (LCA) methodology integrated with a freshwater withdrawal category (FWI) was adopted to compare water supply alternatives in the water-receiving areas of the SNWDP, i.e., water diversion, wastewater reclamation and seawater desalination. Beijing, Tianjin, Jinan and Qingdao were studied as representative cities because they are the primary water-receiving areas of the SNWDP. The results revealed that the operation phase played the dominant role in all but one of the life cycle impact categories considered and contributed to more than 70% of their scores. For Beijing and Tianjin, receiving water through the SNWDP is the most sustainable option to augment the water supply. The result can be drawn in all of the water-receiving areas of the middle route of the SNWDP. For Jinan and Qingdao, the most sustainable option is the wastewater reclamation system. The seawater desalination system obtains the highest score of the standard impact indicators in all of the study areas, whereas it is the most favorable water supply option when considering the freshwater withdrawal impact. Although the most sustainable water supply alternative was recommended through an LCA analysis, multi-water resources should be integrated into the region's water supply from the perspective of water sustainability. The results of this study provide a useful recommendation on the management of water resources for China. Copyright © 2015 Elsevier Ltd. All rights reserved.

Intractable nausea caused by zolpidem withdrawal: a case report.

Science.gov (United States)

Baruch, Edward; Vernon, Leonard F; Hasbun, Rafael J

2007-03-01

First launched in France in 1988, zolpidem (Ambien®) is a short-acting hypnotic agent. Early studies reported that that the development of physical dependence and tolerance to sedative-hypnotic drugs, such as the depressant and anticonvulsant effects evidenced with benzodiazepines, is not found with zolpidem. Direct to consumer advertising by the manufacturer continues to state that the risk for dependency is low; however, recent publications seem to contradict this. Additionally, adverse drug reactions affecting the central nervous system, gastrointestinal tract, and respiratory system have been reported. Other studies have examined the interactions of selective serotonin reuptake inhibitors and zolpidem as a possible cause of hallucinations. With continued physician marketing efforts touting the safety and efficacy of zolpidem, there is a high likelihood to overlook the risk of dependency and the symptoms related to zolpidem withdrawal. We report a case of a 41-year-old female who developed a dependency to zolpidem, who on her own decided to decrease her dosage, resulting in intractable nausea requiring hospitalization. Reported cases of zolpidem withdrawal have occurred with doses in excess of 160 mg per day, none of these have reported with intractable nausea as the sole symptom. In our reported case, although exceeding recommended dosage withdrawal phenomenon seemed to be severe after withdrawal from a comparatively low dose of zolpidem. Before zolpidem is prescribed, patient education should include warnings about the potential problems associated with dependency and abrupt discontinuation. Education about this common and likely underrecognized clinical phenomenon will help prevent future episodes and minimize the risk of misdiagnosis.

Predictors of withdrawal: possible precursors of avoidant personality disorder.

Science.gov (United States)

Eggum, Natalie D; Eisenberg, Nancy; Spinrad, Tracy L; Valiente, Carlos; Edwards, Alison; Kupfer, Anne S; Reiser, Mark

2009-01-01

Relations of avoidant personality disorder (AvPD) with shyness and inhibition suggest that a precursor of AvPD is withdrawal. Using a sample of 4.5- to 7-year-olds studied four times, 2 years apart, four and three classes of children differing in trajectories of mother- and teacher-reported withdrawal, respectively, were identified. Mothers and teachers generally did not agree on children's trajectories but the pattern of findings in the two contexts did not differ markedly. The mother-identified high and declining withdrawal class, in comparison with less withdrawn classes, and the teacher-identified high and declining class compared with low withdrawal classes, were associated with relatively high levels of anger and low levels of attentional control and resiliency. The mother-identified moderate and increasing withdrawal class was distinguished from less problematic withdrawal classes by higher anger, lower resiliency, and sometimes, lower attentional control. The teacher-identified low and increasing withdrawal class was distinguished from less problematic withdrawal classes by lower resiliency and lower attentional control. Findings are discussed in terms of the developmental precursors to social withdrawal and avoidant behavior.

Buprenorphine for managing opioid withdrawal.

Science.gov (United States)

Gowing, Linda; Ali, Robert; White, Jason M; Mbewe, Dalitso

2017-02-21

Managed withdrawal is a necessary step prior to drug-free treatment or as the endpoint of substitution treatment. To assess the effects of buprenorphine versus tapered doses of methadone, alpha 2 -adrenergic agonists, symptomatic medications or placebo, or different buprenorphine regimens for managing opioid withdrawal, in terms of the intensity of the withdrawal syndrome experienced, duration and completion of treatment, and adverse effects. We searched the Cochrane Central Register of Controlled Trials (CENTRAL, Issue 11, 2016), MEDLINE (1946 to December week 1, 2016), Embase (to 22 December 2016), PsycINFO (1806 to December week 3, 2016), and the Web of Science (to 22 December 2016) and handsearched the reference lists of articles. Randomised controlled trials of interventions using buprenorphine to modify the signs and symptoms of withdrawal in participants who were primarily opioid dependent. Comparison interventions involved reducing doses of methadone, alpha 2 -adrenergic agonists (clonidine or lofexidine), symptomatic medications or placebo, and different buprenorphine-based regimens. We used standard methodological procedures expected by Cochrane. We included 27 studies involving 3048 participants. The main comparators were clonidine or lofexidine (14 studies). Six studies compared buprenorphine versus methadone, and seven compared different rates of buprenorphine dose reduction. We assessed 12 studies as being at high risk of bias in at least one of seven domains of methodological quality. Six of these studies compared buprenorphine with clonidine or lofexidine and two with methadone; the other four studies compared different rates of buprenorphine dose reduction.For the comparison of buprenorphine and methadone in tapered doses, meta-analysis was not possible for the outcomes of intensity of withdrawal or adverse effects. However, information reported by the individual studies was suggestive of buprenorphine and methadone having similar capacity to

20 CFR 408.355 - Can you withdraw your application?

Science.gov (United States)

2010-04-01

... Section 408.355 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Filing Applications Withdrawal of Application § 408.355 Can you withdraw your application? (a) Request for withdrawal filed before a determination is made. You may withdraw your application...

21 CFR 514.7 - Withdrawal of applications without prejudice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Withdrawal of applications without prejudice. 514... Withdrawal of applications without prejudice. The sponsor may withdraw his pending application from.... Such withdrawal may be made without prejudice to a future filing. Upon resubmission, the time...

Safety analysis results for the control rod banks withdrawal event at a full power of the SMART-P

International Nuclear Information System (INIS)

Yang, S. H.; Chung, Y. J.; Kim, H. C.; Zee, S. Q.

2005-01-01

For the validation of the 330 MWt SMART (System-integrated Modular Advanced ReacTor), a detailed design for the SMART-P has been accomplished by KAERI. In the SMART-P design similar to the SMART design, the soluble boron free design is adapted. This concept results in a larger reactivity worth of the control rod bank compared to that of the commercial pressurized water reactor. Moreover, in the SMART-P design, the control rod banks are fairly well inserted into the core, even at a full power condition. Therefore, accidents related to the reactivity anomalies have been evaluated as crucial events when compared to the other initiating events. In this paper, safety analysis for the control rod banks withdrawal event at a full power of the SMART-P has been accomplished by considering various initial conditions, different withdrawal times of the control rod banks and the reactivity feedback. To perform the safety analysis, the TASS/SMR (Transients And Setpoint Simulation/Small and Medium Reactor) code for a system response and SSF-1 correlation for a CHFR (Critical Heat Flux Ratio) have been used

47 CFR 76.917 - Notification of certification withdrawal.

Science.gov (United States)

2010-10-01

... certification withdrawal. A franchising authority that has been certified to regulate rates may, at any time... include the franchising authority's determination that rate regulation no longer serves the interests of cable subscribers served by the cable system within the franchising authority's jurisdiction, and that...

Determinants of early withdrawal and of early withdrawal by reason of disability from the Irish labour force in the third age

OpenAIRE

Lawless, Martin

2015-01-01

III – Abstract: Determinants of early withdrawal and early withdrawal by reason of disability from the Irish labour force in the Third Age.Background. This study examines the relationship between early withdrawal and early withdrawal through disability from the Irish labour force in the Third Age. The relationship between unemployment or early retirement and ill health has been determined by a number of studies and, while unemployment through ill health or occupational disability may lead to ...

Estimates of water use and trends in the Colorado River Basin, Southwestern United States, 1985–2010

Science.gov (United States)

Maupin, Molly A.; Ivahnenko, Tamara I.; Bruce, Breton

2018-06-26

1985 and 2010. When comparing domestic daily per-capita rates for the upper and lower CRB, people in the lower CRB, on average, used less water for domestic purposes at 128 gal per-capita daily (1985–2010), while those in the upper CRB for the same time period averaged 133 gal per-capita daily. The trend in daily per-capita use rates for the entire CRB fluctuated between the reporting years, but decreased overall, indicating that more people used less water in 2010 than in 1985, likely due to improved infrastructure, conservation, and improvements to water using appliances in homes and businesses.Irrigation accounted for most total withdrawals in the CRB, excluding instream use for hydroelectric power and interbasin transfers, averaging 85 percent from 1985 to 2010. Far more surface water than groundwater was used for irrigation in both the upper and lower CRB, but in the upper CRB, it accounted for an average of more than 98 percent of the total withdrawals (1985–2010), whereas in the lower CRB, surface-water withdrawals for irrigation averaged 61 percent of total withdrawals. On average, the upper CRB accounted for 56 percent of total irrigated acres, and the irrigation systems in the upper CRB trended towards more efficient sprinkler systems from 1985 to 2010. Long-term drought in the CRB substantially decreased the amount of streamflow available for irrigation. Increases in micro-irrigation acres, which can have efficiencies that exceed 90 percent and require 20–50 percent less water than sprinkler systems, likely contributed to reduced withdrawals in the lower CRB.For thermoelectric power, total withdrawals, including the use of reclaimed wastewater, were greater in the upper CRB from 1985 through 2005. In 2010, the lower CRB exceeded the upper by only 11,000 acre-feet. On average, thermoelectric consumptive use accounted for about 80 percent of the total withdrawals; however, consumptive-use data in the upper CRB was incomplete. Surface water was the

Summary of estimated water use in the United States in 2015

Science.gov (United States)

Maupin, Molly A.

2018-06-19

A total of 322 Bgal/d of water withdrawals was reported for eight categories of use in the United States in 2015, which was 9 percent less than in 2010 (354 Bgal/d), and continued a declining trend since 2005. The decline in total withdrawals in 2015 primarily was caused by significant decreases (28.8 Bgal/d) in thermoelectric power, which accounted for 89 percent of the decrease in total withdrawals. Between 2010 and 2015, withdrawals decreased in all categories except irrigation (2 percent increase), mining (1 percent increase), and livestock (no change). Fresh surface-water withdrawals (198 Bgal/d) were 14 percent less than in 2010, and fresh groundwater withdrawals (82.3 Bgal/d) were about 8 percent more than in 2010. Saline surface-water withdrawals (38.6 Bgal/d) were 14 percent less than in 2010, and saline groundwater withdrawals (2.34 Bgal/d) were 5 percent more than in 2010. Total population in the United States in 2015 (325 million) increased by 4 percent (12.4 million) from 2010, which was similar to the increase between 2005 and 2010. For the first time since 1995, consumptive use for irrigation and thermoelectric power were reported. Consumptive use accounted for 62 percent (73.2 Bgal/d) of water used for irrigation, and 3 percent (4.31 Bgal/d) of water used for thermoelectric power in 2015.

20 CFR 404.640 - Withdrawal of an application.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Withdrawal of an application. 404.640 Section 404.640 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Filing of Applications and Other Forms Withdrawal of Application § 404.640 Withdrawal of...

20 CFR 416.355 - Withdrawal of an application.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Withdrawal of an application. 416.355 Section 416.355 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Filing of Applications Withdrawal of Application § 416.355 Withdrawal of an...

Withdrawal symptoms in internet gaming disorder: A systematic review.

Science.gov (United States)

Kaptsis, Dean; King, Daniel L; Delfabbro, Paul H; Gradisar, Michael

2016-02-01

Internet gaming disorder (IGD) is currently positioned in the appendix of the DSM-5 as a condition requiring further study. The aim of this review was to examine the state of current knowledge of gaming withdrawal symptomatology, given the importance of withdrawal in positioning the disorder as a behavioral addiction. A total of 34 studies, including 10 qualitative studies, 17 research reports on psychometric instruments, and 7 treatment studies, were evaluated. The results indicated that the available evidence on Internet gaming withdrawal is very underdeveloped. Internet gaming withdrawal is most consistently referred to as 'irritability' and 'restlessness' following cessation of the activity. There exists a concerning paucity of qualitative studies that provide detailed clinical descriptions of symptoms arising from cessation of internet gaming. This has arguably compromised efforts to quantify withdrawal symptoms in empirical studies of gaming populations. Treatment studies have not reported on the natural course of withdrawal and/or withdrawal symptom trajectory following intervention. It is concluded that many more qualitative clinical studies are needed, and should be prioritised, to develop our understanding of gaming withdrawal. This should improve clinical descriptions of problematic internet gaming and in turn improve the quantification of IGD withdrawal and thus treatments for harmful internet gaming. Copyright © 2015 Elsevier Ltd. All rights reserved.

Withdrawal from long-term hemodialysis in patients with end-stage renal disease in Taiwan.

Science.gov (United States)

Lai, Chun-Fu; Tsai, Hung-Bin; Hsu, Su-Hsuan; Chiang, Chih-Kang; Huang, Jenq-Wen; Huang, Sheng-Jean

2013-10-01

Withdrawal from dialysis is ethically appropriate for some patients with multiple comorbidities and a shortened life expectancy. Taiwan has the highest prevalence of dialysis patients in the world, and the National Health Insurance (NHI) program offers renal replacement therapy free of charge. In this review, we discuss its current status and many background issues related to withdrawing dialysis from patients with advanced renal failure in Taiwan. Compared with dialysis therapy, the medical resources for hospice care are relatively sparse. Since the announcement of the Statute for Palliative Care in 2000, there has been a gradual improvement in the laws and health polices supporting dialysis withdrawal. Culture and social customs also have a significant impact on the practice of hospice care. Based on current evidence and in accordance with the local environment, we propose recommendations for the clinical practice of dialysis withdrawal and hospice care. There remains a need to expand upon the community-based hospice care and home care systems to better serve patients. In conclusion, there are cross-cultural differences relating to dialysis withdrawal between Taiwan and Western countries. Our experience and clinical recommendations may be helpful for the countries with NHI systems or for the Eastern countries. Copyright © 2013. Published by Elsevier B.V.

41 CFR 101-39.105-2 - Agency requests to withdraw participation.

Science.gov (United States)

2010-07-01

..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.105-2 Agency requests to withdraw participation. (a) Executive agencies receiving motor vehicle services from fleet management systems may request...

SSRI and SNRI withdrawal symptoms reported on an internet forum.

Science.gov (United States)

Stockmann, Tom; Odegbaro, Dolapo; Timimi, Sami; Moncrieff, Joanna

2018-05-09

Antidepressant withdrawal symptoms are well-recognised, but their potential duration remains uncertain. We aimed to describe the characteristics of withdrawal associated with two popular classes of antidepressants, including duration. We analysed the content of a sample of posts on an antidepressant withdrawal website. We compared the characteristics of withdrawal associated with SSRIs and SNRIs, including time of onset, duration and nature of symptoms. 110 posts about SSRI withdrawal, and 63 concerning SNRI withdrawal, were analysed. The mean duration of withdrawal symptoms was significantly longer with SSRIs than SNRIs: 90.5 weeks (standard deviation, SD, 150.0) and 50.8 weeks (SD 76.0) respectively; p = 0.043). Neurological symptoms, such as 'brain zaps,' were more common among SNRI users (p = 0.023). Psychosexual/genitourinary symptoms may be more common among SSRI users (p = 0.054). The website aims to help people with antidepressant withdrawal, and is therefore likely to attract people who have difficulties. Length of prior use of antidepressants was long, with a mean of 252.2 weeks (SD 250.8). People accessing antidepressant withdrawal websites report experiencing protracted withdrawal symptoms. There are some differences in the characteristics of withdrawal associated with different classes of antidepressants.

The Non-Proliferation Treaty and the Withdrawal Clause

International Nuclear Information System (INIS)

Boutherin, Gregory

2008-01-01

Like any international agreement, the NPT includes a withdrawal clause. The North Korean withdrawal, which was announced in 1993 and became effective in 2003, shows how difficult it is to preserve this possibility, while guaranteeing compliance with signed agreements. To achieve this target, two conditions are required: first, enhancing the means by which the reasons for withdrawals can be made clear and second, to allow the Security Council to draw all the consequences of withdrawals that could imply that a treaty has been violated

Effects of water-supply reservoirs on streamflow in Massachusetts

Science.gov (United States)

Levin, Sara B.

2016-10-06

reservoir simulation tool was used to simulate 35 single- and multiple-reservoir systems in Massachusetts over a 44-year period (water years 1961 to 2004) under two water-use scenarios. The no-pumping scenario assumes no water withdrawal pumping, and the pumping scenario incorporates average annual pumping rates from 2000 to 2004. By comparing the results of the two scenarios, the total streamflow alteration can be parsed into the portion of streamflow alteration caused by the presence of a reservoir and the additional streamflow alteration caused by the level of water use of the system.For each reservoir system, the following metrics were computed to characterize the frequency, duration, and magnitude of reservoir outflow volumes compared with unaltered streamflow conditions: (1) the median number of days per year in which the reservoir did not spill, (2) the median duration of the longest consecutive period of no-spill days per year, and (3) the lowest annual flow duration exceedance probability at which the outflows are significantly different from estimated unaltered streamflow at the 95-percent confidence level. Most reservoirs in the study do not spill during the summer months even under no-pumping conditions. The median number of days during which there was no spillage was less than 365 for all reservoirs in the study, indicating that, even under reported pumping conditions, the reservoirs refill to full volume and spill at least once during nondrought years, typically in the spring.Thirteen multiple-reservoir systems consisting of two or three hydrologically connected reservoirs were included in the study. Because operating rules used to manage multiple-reservoir systems are not available, these systems were simulated under two pumping scenarios, one in which water transfers between reservoirs are minimal and one in which reservoirs continually transferred water to intermediate or terminal reservoirs. These two scenarios provided upper and lower estimates of

Delirium and High Creatine Kinase and Myoglobin Levels Related to Synthetic Cannabinoid Withdrawal

Directory of Open Access Journals (Sweden)

Ahmet Bulent Yazici

2017-01-01

Full Text Available Synthetic cannabinoids (SCs are included in a group of drugs called new psychoactive substances. Effects of SCs on the central nervous system are similar to other cannabinoids, but 2–100 times more potent than marijuana. Thus, addiction and withdrawal symptoms are more severe than natural cannabinoids. Withdrawal symptoms of SCs were reported in the literature previously. But there is no report about SC withdrawal delirium and its treatment. Several studies reported that agonists of CB1 receptors play a role in GABA and glutamatergic neurotransmission, which is similar to the effects of alcohol on GABA and glutamatergic receptors. Previous studies on alcohol delirium cases suggested that elevated creatine kinase (CK can be a marker of progress. This study reports delirium and high serum CK levels related to SC withdrawal and offers a treatment with benzodiazepine for them. We described two cases treated in our inpatient clinic about SC withdrawal with increase of serum CK level and other laboratory parameters. One of them demonstrated delirium symptoms and the other did not with early rapid treatment.

Withdrawal of immunosuppresive agents in the treatment of disseminated coccidioidomycosis.

Science.gov (United States)

Kaplan, J E; Zoschke, D; Kisch, A L

1980-04-01

Disseminated coccidioidomycosis is a systemic fungal infection that causes high mortality in the renal transplatn patient. Cell-mediated immunity, which appears to be the relevant host defense mechanism, is impaired by the immunosupressive agents used to prevent allograft rejection. In the case presented, immunosuppressive therapy was stopped as an adjunct to treatment of this infection. The patient has shown evidence of improvement, and his allograft has continued to function nine months after the withdrawal of immunosuppressive therapy and 18 months after the diagnosis. In vitro lymphocyte function studies indicate that the impairment in cell-mediated immunity detected prior to withdrawal of immunosuppressive therapy has persisted, probably accounting for allograft survival. Withdrawal of immunosuppressive therapy may prolong survival in renal transplant patients with disseminated coccidioidomycosis. Additionally, depression in cell-mediated immunity associated with the fungal infection itself may be sufficient to prevent allograft rejection in these patients.

Withdrawal-oriented therapy for smokers.

Science.gov (United States)

Hajek, P

1989-06-01

The treatment approach of the Maudsley Hospital Smokers Clinic is described. It stems from the notion that smokers seeking help are dependent on nicotine, and that withdrawal discomfort is a major block to their success in quitting. Accordingly, therapy focuses on helping clients overcome nicotine deprivation. It uses nicotine replacement and a special format of group treatment. Details are given of preparation of clients, use of nicotine chewing gum, use of group-oriented groupwork, use of information about withdrawal, and training in withdrawal-oriented therapy. Data are presented concerning characteristics of the clientele, treatment adherence, and treatment results. A number of controversial issues are addressed, such as the optimal duration of treatment, timing of the quit date, the value of educational input, and the value of individualization of treatment goals.

Documentation of methods and inventory of irrigation data collected for the 2000 and 2005 U.S. Geological Survey Estimated use of water in the United States, comparison of USGS-compiled irrigation data to other sources, and recommendations for future compilations

Science.gov (United States)

Dickens, Jade M.; Forbes, Brandon T.; Cobean, Dylan S.; Tadayon, Saeid

2011-01-01

Every five years since 1950, the U.S. Geological Survey (USGS) National Water Use Information Program (NWUIP) has compiled water-use information in the United States and published a circular report titled "Estimated use of water in the United States," which includes estimates of water withdrawals by State, sources of water withdrawals (groundwater or surface water), and water-use category (irrigation, public supply, industrial, thermoelectric, and so forth). This report discusses the impact of important considerations when estimating irrigated acreage and irrigation withdrawals, including estimates of conveyance loss, irrigation-system efficiencies, pasture, horticulture, golf courses, and double cropping.

Occurrence and fate of acrylamide in water-recycling systems and sludge in aggregate industries.

Science.gov (United States)

Junqua, Guillaume; Spinelli, Sylvie; Gonzalez, Catherine

2015-05-01

Acrylamide is a hazardous substance having irritant and toxic properties as well as carcinogen, mutagen, and impaired fertility possible effects. Acrylamide might be found in the environment as a consequence of the use of polyacrylamides (PAMs) widely added as a flocculant for water treatment. Acrylamide is a monomer used to produce polyacrylamide (PAM) polymers. This reaction of polymerization can be incomplete, and acrylamide molecules can be present as traces in the commercial polymer. Thus, the use of PAMs may generate a release of acrylamide in the environment. In aggregate industries, PAM is widely involved in recycling process and water reuse (aggregate washing). Indeed, these industries consume large quantities of water. Thus, European and French regulations have favored loops of recycling of water in order to reduce water withdrawals. The main goal of this article is to study the occurrence and fate of acrylamide in water-recycling process as well as in the sludge produced by the flocculation treatment process in aggregate production plants. Moreover, to strengthen the relevance of this article, the objective is also to demonstrate if the recycling system leads to an accumulation effect in waters and sludge and if free acrylamide could be released by sludge during their storage. To reach this objective, water sampled at different steps of recycling water process has been analyzed as well as different sludge corresponding to various storage times. The obtained results reveal no accumulation effect in the water of the water-recycling system nor in the sludge.

MITS Feed and Withdrawal Subsystem: operating procedures

International Nuclear Information System (INIS)

Brown, W.S.

1980-01-01

This document details procedures for the operation of the MITS (Machine Interface Test System) Feed and Withdrawal Subsystem (F and W). Included are fill with UF 6 , establishment of recycle and thruput flows, shutdown, UF 6 makeup, dump to supply container, Cascade dump to F and W, and lights cold trap dump, all normal procedures, plus an alternate procedure for trapping light gases

Opiate Withdrawal Complicated by Tetany and Cardiac Arrest

Directory of Open Access Journals (Sweden)

Irfanali R. Kugasia

2014-01-01

Full Text Available Patients with symptoms of opiate withdrawal, after the administration of opiate antagonist by paramedics, are a common presentation in the emergency department of hospitals. Though most of opiate withdrawal symptoms are benign, rarely they can become life threatening. This case highlights how a benign opiate withdrawal symptom of hyperventilation led to severe respiratory alkalosis that degenerated into tetany and cardiac arrest. Though this patient was successfully resuscitated, it is imperative that severe withdrawal symptoms are timely identified and immediate steps are taken to prevent catastrophes. An easier way to reverse the severe opiate withdrawal symptom would be with either low dose methadone or partial opiate agonists like buprenorphine. However, if severe acid-base disorder is identified, it would be safer to electively intubate these patients for better control of their respiratory and acid-base status.

The alcohol withdrawal syndrome.

LENUS (Irish Health Repository)

McKeon, A

2008-08-01

The alcohol withdrawal syndrome (AWS) is a common management problem in hospital practice for neurologists, psychiatrists and general physicians alike. Although some patients have mild symptoms and may even be managed in the outpatient setting, others have more severe symptoms or a history of adverse outcomes that requires close inpatient supervision and benzodiazepine therapy. Many patients with AWS have multiple management issues (withdrawal symptoms, delirium tremens, the Wernicke-Korsakoff syndrome, seizures, depression, polysubstance abuse, electrolyte disturbances and liver disease), which requires a coordinated, multidisciplinary approach. Although AWS may be complex, careful evaluation and available treatments should ensure safe detoxification for most patients.

Intentional intrathecal opioid detoxification in 3 patients: characterization of the intrathecal opioid withdrawal syndrome.

Science.gov (United States)

Jackson, Tracy P; Lonergan, Daniel F; Todd, R David; Martin, Peter R

2013-04-01

Intrathecal (IT) drug delivery systems for patients with chronic non-malignant pain are intended to improve pain and quality of life and reduce side effects of systemic use. A subset of patients may have escalating pain, functional decline, and/or intolerable side effects even as IT opioid doses are increased. Discontinuation of IT medications may represent a viable treatment option but strategies to accomplish this are needed. Three patients with intrathecal drug delivery systems (IDDS), inadequate pain control, and declining functionality underwent abrupt IT opioid cessation. This was accomplished through a standardized protocol with symptom-triggered administration of clonidine and buprenorphine, monitored using the clinical opiate withdrawal scale. Symptoms of IT withdrawal were similar in all patients and included diuresis, agitation, hyperalgesia, mild diarrhea, yawning, and taste and smell aversion. Hypertension and tachycardia were effectively controlled by clonidine administration. Classic symptoms of withdrawal, such as piloerection, chills, severe diarrhea, nausea, vomiting, diaphoresis, myoclonus, and mydriasis, were not noted. At 2 to 3 months follow-up, patients reported decreased, but ongoing pain, with improvements in functional capacity and quality of life. This preliminary work demonstrates the safety of abrupt IT opioid cessation utilizing standardized inpatient withdrawal protocols. To our knowledge, these are among the first reported cases of intentional, controlled IT opioid cessation without initiation of an opioid bridge: self-reported pain scores, functional capacity, and quality of life improved. The IT opioid withdrawal syndrome is characterized based upon our observations and a review of the literature. © 2012 The Authors. Pain Practice © 2012 World Institute of Pain.

42 CFR 457.170 - Withdrawal process.

Science.gov (United States)

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Withdrawal process. 457.170 Section 457.170 Public... Plans for Child Health Insurance Programs and Outreach Strategies § 457.170 Withdrawal process. (a... amendment, or any portion of a proposed State plan or plan amendment, at any time during the review process...

Analysis of potential water-supply management options, 2010-60, and documentation of revisions to the model of the Irwin Basin Aquifer System, Fort Irwin National Training Center, California

Science.gov (United States)

Voronin, Lois M.; Densmore, Jill N.; Martin, Peter

2014-01-01

The Fort Irwin National Training Center is considering several alternatives to manage their limited water-supply sources in the Irwin Basin. An existing three-dimensional, finite-difference groundwater-flow model—the U.S. Geological Survey’s MODFLOW—of the aquifer system in the basin was updated and the initial input dataset was supplemented with groundwater withdrawal data for the period 2000–10. The updated model was then used to simulate four combinations, or scenarios, of groundwater withdrawal and recharge over the next 50 years (January 2011 through December 2060). The scenarios included combinations of continuing withdrawals from currently active production wells, supplementing any increases in demand with withdrawals from an inactive production well, reducing withdrawal amounts and rates, and reducing the discharge of treated wastewater to infiltration ponds that provide a recharge source to the underlying aquifer. Results of the simulations indicated that, depending on the scenario implemented, groundwater levels would rise (over the next 50 years) from 40 feet to as much as 65 feet in the northwestern part of the Irwin Basin, and from 5 feet to 10 feet in the southeastern part.

Effect of Morphine Withdrawal Syndrome on Cerebral Ischemia

Directory of Open Access Journals (Sweden)

Mohammad Allahtavakoli

2011-01-01

Full Text Available Objective(sOpioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema. In the present study, we investigated whether spontaneously withdrawal syndrome might affect stroke outcomes.Materials and MethodsAddiction was induced by progressive incremental doses of morphine over 7 days. Behavioral signs of withdrawal were observed 24, 48 and 72 hr after morphine deprivation and total withdrawal score was determined. Cerebral ischemia was induced 18-22 hr after the last morphine injection by placing a natural clot into the middle cerebral artery (MCA. Neurological deficits were evaluated at 2, 24 and 48 hr after ischemia induction, and infarct size and brain edema were determined at 48 hr after stroke.ResultsMorphine withdrawal animals showed a significant increase in total withdrawal score and decrease of weight gain during the 72 hr after the last morphine injection. Compared to the addicted and control animals, infarct volume and brain edema were significantly increased in the morphine deprived animals (P< 0.05 at 48 hr after cerebral ischemia. Also, neurological deficits were higher in the morphine-withdrawn rats at 48 hr after stroke (P< 0.05. ConclusionOur data indicates that spontaneous withdrawal syndrome may worsen stroke outcomes. Further investigations are necessary to elucidate mechanisms of opiate withdrawal syndrome on stroke.

Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish.

Directory of Open Access Journals (Sweden)

Beng-Siang Khor

Full Text Available A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to mitigate the harshness of drug withdrawal. A series of experiments was conducted to investigate the effect of mitragynine on anxiety behavior, cortisol level and expression of stress pathway related genes in zebrafish undergoing morphine withdrawal phase. Adult zebrafish were subjected to two weeks chronic morphine exposure at 1.5 mg/L, followed by withdrawal for 24 hours prior to tests. Using the novel tank diving tests, we first showed that morphine-withdrawn zebrafish display anxiety-related swimming behaviors such as decreased exploratory behavior and increased erratic movement. Morphine withdrawal also elevated whole-body cortisol levels, which confirms the phenotypic stress-like behaviors. Exposing morphine-withdrawn fish to mitragynine however attenuates majority of the stress-related swimming behaviors and concomitantly lower whole-body cortisol level. Using real-time PCR gene expression analysis, we also showed that mitragynine reduces the mRNA expression of corticotropin releasing factor receptors and prodynorphin in zebrafish brain during morphine withdrawal phase, revealing for the first time a possible link between mitragynine's ability to attenuate anxiety during opiate withdrawal with the stress-related corticotropin pathway.

Water withdrawal for brackish and inland aquaculture, and options to produce more fish in ponds with present water use

NARCIS (Netherlands)

Verdegem, M.C.J.; Bosma, R.H.

2009-01-01

This paper reviews freshwater use in inland and coastal pond aquaculture, and focuses on options to increase productivity while reducing water use. Total freshwater use depends on system-associated and feed-associated water losses. System-associated water losses depend on total area, evaporation,

Sources of water to wells in updip areas of the Wenonah-Mount Laurel aquifer, Gloucester and Camden Counties, New Jersey

Science.gov (United States)

Watt, Martha K.; Voronin, Lois M.

2006-01-01

Since 1996, when the New Jersey Department of Environmental Protection (NJDEP) restricted ground-water withdrawals from the Potomac-Raritan-Magothy aquifer system in the southern New Jersey Coastal Plain as a result of excessive drawdown, Coastal Plain communities have been interested in developing alternate sources of water supply for their residents. The use of ground water from areas near the updip parts of the overlying confined aquifers where withdrawals are not restricted is being considered to meet the demand for drinking water. Concerns have arisen, however, regarding the potential effects of increased withdrawals from these areas on ground-water flow to streams and wetlands as well as to the deeper, confined parts of the aquifers. Therefore, the U.S. Geological Survey, in cooperation with the NJDEP, conducted a study to investigate the sources of water to currently inactive wells in the updip part of the Wenonah-Mount Laurel aquifer in Gloucester and Camden Counties, New Jersey. Of particular interest is whether the primary source of the increased withdrawals is likely to be the aquifer outcrop or the downdip, confined part of the aquifer. The outcrop of the Wenonah-Mount Laurel aquifer covers nearly 8 mi2 (square miles), or about 46 percent of Deptford Township's 17.56-mi2 area. The Deptford Township Municipal Utilities Authority owns six currently (2005) inactive wells in the Wenonah-Mount Laurel aquifer at the southeastern boundary of Deptford Township, 1.25 mi (miles) from the outcrop. For the purposes of this study, an existing ground-water-flow model of the New Jersey Coastal Plain aquifers was used to simulate ground-water-flow conditions in Gloucester and Camden Counties in 1998. Two alternative withdrawal scenarios were superimposed on the results of the 1998 simulation. In the first (the 'full-allocation' scenario), full-allocation withdrawal rates established by the NJDEP were applied to 45 existing wells in the Deptford Township area. In the

Withdrawing to a Virtual World: Associations between Subtypes of Withdrawal, Media Use, and Maladjustment in Emerging Adults

Science.gov (United States)

Nelson, Larry J.; Coyne, Sarah M.; Howard, Emily; Clifford, Brandon N.

2016-01-01

An approach-avoidance model of social withdrawal (Asendorpf, 1990) identifies 3 types of social withdrawal including shyness, unsociability, and avoidance. Each appears to be uniquely associated with varying indicators of maladjustment in emerging adulthood (Nelson, 2013) but little, if any, work has been done to see how they might be linked to…

An overview of research on social withdrawal in childhood

OpenAIRE

野村, あすか; NOMURA, Asuka

2013-01-01

In recent years, “HIKIKOMORI” in adolescence or adulthood has grown into a serious problem in Japan and the need for early intervention and support has been emphasized. Among the risk factors of “HIKIKOMORI” is social withdrawal in childhood. With this in mind, I reviewed previous studies on the social withdrawal in children living abroad. The review commences with an examination of definitions of social withdrawal, which showed that in some foreign countries, social withdrawal refers to the ...

Why withdrawal from the European Union is undemocratic

DEFF Research Database (Denmark)

Olsen, Tore Vincents; Rostbøll, Christian F.

2017-01-01

The Lisbon Treaty from 2009 introduced the possibility for individual member states to withdraw from the European Union (EU) on the basis of a unilateral decision. In June 2016 the UK decided to leave the EU invoking article 50 of the treaty. But is withdrawal democratically legitimate? In fact......, the all affected principle suggests that it is undemocratic for subunits to leave larger political units when it adversely affects other citizens without including them in the decision. However, it is unclear what the currency of this affectedness is and, hence, why withdrawal would be undemocratic. We...... argue that it is the effect of withdrawal on the status of citizens as free and equal that is decisive and that explains why unilateral withdrawal of subunits from larger units is democratically illegitimate. Moreover, on the ‘all affected status principle’ that we develop, even multilaterally agreed...

Cortical and spinal assessment - a comparative study using encephalography and the nociceptive withdrawal reflex

DEFF Research Database (Denmark)

Fischer, I W; Gram, M; Hansen, T M

2017-01-01

solution in randomized order. The electroencephalogram (EEG) was recorded during rest and during immersion of the hand into ice-water. Electrical stimulation of the sole of the foot was used to elicit the nociceptive withdrawal reflex and the reflex amplitude was recorded. RESULTS: Data from thirty...

Global water scarcity: the monthly blue water footprint compared to blue water availability for the world's major river basins

NARCIS (Netherlands)

Hoekstra, Arjen Ysbert; Mekonnen, Mesfin

Conventional blue water scarcity indicators suffer from four weaknesses: they measure water withdrawal instead of consumptive water use, they compare water use with actual runoff rather than natural (undepleted) runoff, they ignore environmental flow requirements and they evaluate scarcity on an

APR1400 CEA Withdrawal at Power Accident Analysis using KNAP

International Nuclear Information System (INIS)

Lee, Dong-Hyuk; Yang, Chang-Keun; Kim, Yo-Han; Sung, Chang-Kyung

2006-01-01

KEPRI (Korea Electric Power Research Institute) has been developing safety analysis methodology for non- LOCA (Loss Of Coolant Accident) analysis of OPR1000 (Optimized Power Reactor 1000, formerly KSNP). The new methodology, named KNAP (Korea Non-LOCA Analysis Package), uses RETRAN as the main system analysis code. RETRAN code is a non- LOCA safety analysis code developed by EPRI. The new methodology will replace existing CE (Combustion Engineering) supplied codes and methodologies currently used in non-LOCA analysis of OPR1000. In this paper, we apply KNAP methodology to APR1400 (Advanced Power Reactor 1400). The CEA (Control Element Assembly) withdrawal at power accident is one of the 'reactivity and power distribution anomalies' events and the results are typically described in the chapter 15.4.2 of SAR (Safety Analysis Report). The APR1400 has been designed to generate 1,400MWe of electricity with advanced features for greatly enhanced safety and economic goals. The CEA withdrawal at power analysis in APR1400 SSAR (Standard Safety Analysis Report) is analyzed with CESEC-III computer code. In this study, to confirm the applicability of the KNAP methodology and code system to APR1400, CEA withdrawal at power accident is analyzed using RETRAN code and it is compared with results from APR1400 SSAR

Shallow ground-water conditions, Tom Green County, Texas

Science.gov (United States)

Lee, J.N.

1986-01-01

Most of the water needs of Tom Green County, Texas, are supplied by ground water; however, the city of San Angelo is supplied by surface water. Groundwater withdrawals during 1980 (latest year for which data are available) in Tom Green County totaled about 15,300 acre-feet, all derived from shallow aquifers. Shallow aquifers in this report refer to the ground-water system generally less than 400 feet deep that contains water with less than a 10,000 milligrams per liter concentration of dissolved solids; aquifers comprising this system include: The Leona, Comanche Peak, Trinity, Blaine, San Angelo, Choza, Bullwagon, Vale, Standpipe, and Arroyo aquifers.

Valuation of power oscillations in a BWR after control rod banks withdrawal events

International Nuclear Information System (INIS)

Costa, A. L.; Pereira, C.; Da Silva, C. A. M.; Veloso, M. A. F.

2009-01-01

The out-of-phase mode of oscillation is a very challenging type of instability occurring in BWR (Boiling Water Reactor) and its study is relevant because of the safety implications related to the capability to promptly detect any such inadvertent occurrence by in-core neutron detectors, thus triggering the necessary countermeasures in terms of selected rod insertion or even reactor shutdown. In this work, control rod banks (CRB) withdrawal transient was considered to study the power instability occurring in a BWR. To simulate this transient, the control rod banks were continuously removed from the BWR core in different cases. The simulation resulted in a very large increase of power. To perform the instability simulations, the RELAP5/MOD3.3 thermal hydraulic system code was coupled with the PARCS/2.4 3D neutron kinetic code. Data from a real BWR, the Peach Bottom, have been used as reference conditions and reactor parameters. The trend of the mass flow rate, pressure, coolant temperature and the void fraction to four thermal hydraulic channels symmetrically located in the core with respect to the core centre, were taken. It appears that the velocity of the rod bank withdrawal is a very important aspect for reactor stability. The slowest CRB withdrawal (180 s) did not cause power perturbation while the fast removal (20 s) triggered a slow power oscillation that little by little amplified to reach levels of more 100% of the initial power after about 210 s. The investigation of the related thermo hydraulic parameters showed that the mass flow rate, the void fraction and also the coolant temperature began to oscillate at approximately the same time interval

Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats.

Science.gov (United States)

Khaliq, Saima; Haider, Saida; Naqvi, Faizan; Perveen, Tahira; Saleem, Sadia; Haleem, Darakhshan Jabeen

2012-01-01

Caffeine administration has been shown to enhance performance and memory in rodents and humans while its withdrawal on the other hand produces neurobehavioral deficits which are thought to be mediated by alterations in monoamines neurotransmission. A role of decreased brain 5-HT (5-hydroxytryptamine, serotonin) levels has been implicated in impaired cognitive performance and depression. Memory functions of rats were assessed by Water Maze (WM) and immobility time by Forced Swim Test (FST). The results of this study showed that repeated caffeine administration for 6 days at 30 mg/kg dose significantly increases brain 5-HT (pcaffeine. Withdrawal of caffeine however produced memory deficits and significantly increases the immobility time of rats in FST. The results of this study are linked with caffeine induced alterations in serotonergic neurotransmission and its role in memory and depression.

Quantifying the potential effects of high-volume water extractions on water resources during natural gas development: Marcellus Shale, NY

Directory of Open Access Journals (Sweden)

Laura C. Best

2014-07-01

New hydrological insights for the region: The potential effects of the withdrawal scenarios on both the water table and stream discharge were quantified. Based on these impact results, locations in the aquifer and stream networks were identified, which demonstrate particular vulnerability to increased withdrawals and their distribution. These are the locations of importance for planners and regulators who oversee water permitting, to reach a sustainable management of the water resources under changing conditions of energy and corresponding water demand.

Hydrologic conditions, recharge, and baseline water quality of the surficial aquifer system at Jekyll Island, Georgia, 2012-13

Science.gov (United States)

Gordon, Debbie W.; Torak, Lynn J.

2016-03-08

An increase of groundwater withdrawals from the surficial aquifer system on Jekyll Island, Georgia, prompted an investigation of hydrologic conditions and water quality by the U.S. Geological Survey during October 2012 through December 2013. The study demonstrated the importance of rainfall as the island’s main source of recharge to maintain freshwater resources by replenishing the water table from the effects of hydrologic stresses, primarily evapotranspiration and pumping. Groundwater-flow directions, recharge, and water quality of the water-table zone on the island were investigated by installing 26 shallow wells and three pond staff gages to monitor groundwater levels and water quality in the water-table zone. Climatic data from Brunswick, Georgia, were used to calculate potential maximum recharge to the water-table zone on Jekyll Island. A weather station located on the island provided only precipitation data. Additional meteorological data from the island would enhance potential evapotranspiration estimates for recharge calculations.

Assessment of the MDNBR enhancement methodologies for the SMART control rods banks withdrawal event

International Nuclear Information System (INIS)

Yang, Soo Hyung; Chung, Young-Jong; Kim, Hee Cheol

2005-01-01

For an electricity generation and seawater desalination, a 330 MW System-integrated Modular Advanced ReacTor (SMART) was developed by KAERI. The safety level of the SMART is enhanced when compared to that of the typical commercial reactors, with the aid of an elimination of a large break loss of coolant accident by placing the major components of the primary system in a reactor vessel and the adoption of a new technology and a passive design concept into the safety system. However, the events related to reactivity and power distribution anomalies have been evaluated as vulnerable points when compared to the other initiating events in the SMART, since the reactivity worth of the control rods (CR) banks is quite large due to the boron free core concept. Especially, safety margins, i.e., minimum departure from nucleate boiling ratio (MDNBR), are significantly threatened during the CR banks withdrawal event. Therefore, MDNBR enhancement methodology for the CR banks withdrawal event should be considered to further enhance the safety level of the SMART design. Two methodologies have been suggested to enhance the MDNBR during the CR banks withdrawal event: the application of a DNBR trip function into a core protection system and a turbine trip delay methodology. Sensitivity studies are performed to evaluate the two MDNBR enhancement methodologies and show that the suggested methodologies could enhance the MDNBR during the CR banks withdrawal event of the SMART

Depletion and capture: revisiting “The source of water derived from wells"

Science.gov (United States)

Konikow, Leonard F.; Leake, Stanley A.

2014-01-01

A natural consequence of groundwater withdrawals is the removal of water from subsurface storage, but the overall rates and magnitude of groundwater depletion and capture relative to groundwater withdrawals (extraction or pumpage) have not previously been well characterized. This study assesses the partitioning of long-term cumulative withdrawal volumes into fractions derived from storage depletion and capture, where capture includes both increases in recharge and decreases in discharge. Numerical simulation of a hypothetical groundwater basin is used to further illustrate some of Theis' (1940) principles, particularly when capture is constrained by insufficient available water. Most prior studies of depletion and capture have assumed that capture is unconstrained through boundary conditions that yield linear responses. Examination of real systems indicates that capture and depletion fractions are highly variable in time and space. For a large sample of long-developed groundwater systems, the depletion fraction averages about 0.15 and the capture fraction averages about 0.85 based on cumulative volumes. Higher depletion fractions tend to occur in more arid regions, but the variation is high and the correlation coefficient between average annual precipitation and depletion fraction for individual systems is only 0.40. Because 85% of long-term pumpage is derived from capture in these real systems, capture must be recognized as a critical factor in assessing water budgets, groundwater storage depletion, and sustainability of groundwater development. Most capture translates into streamflow depletion, so it can detrimentally impact ecosystems.

Financial tools to induce cooperation in power asymmetrical water systems

Science.gov (United States)

Denaro, Simona; Castelletti, Andrea; Giuliani, Matteo; Characklis, Gregory W.

2017-04-01

irrespective of the timing of downstream users, i.e., farmers, demands. This situation can lead to financial losses by the farmers, an already disadvantaged group, and, as demonstrated by previous work, lead the global system to underperform. Results suggest that financial hedging tools may offer a reliable and relatively inexpensive alternative to other forms of compensation, and thereby favor more equitable management of multi-purpose water systems characterized by power asymmetry. This finding is especially relevant in times where granting of licenses to use/withdrawal water are often being reviewed with attention to environmental protection and social justice issues.

15 CFR 10.13 - Withdrawal of a published standard.

Science.gov (United States)

2010-01-01

...) Before withdrawing a standard published under these procedures, the Director will review the relative... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Withdrawal of a published standard. 10... DEVELOPMENT OF VOLUNTARY PRODUCT STANDARDS § 10.13 Withdrawal of a published standard. (a) Standards published...

Demand-Withdraw Patterns in Marital Conflict in the Home.

Science.gov (United States)

Papp, Lauren M; Kouros, Chrystyna D; Cummings, E Mark

2009-06-01

The present study extended laboratory-based findings of demand-withdraw communication into marital conflict in the home and further explored its linkages with spousal depression. U.S. couples (N = 116) provided diary reports of marital conflict and rated depressive symptoms. Hierarchical linear modeling results indicated that husband demand-wife withdraw and wife demand-husband withdraw occurred in the home at equal frequency, and both were more likely to occur when discussing topics that concerned the marital relationship. For both patterns, conflict initiator was positively linked to the demander role. Accounting for marital satisfaction, both demand-withdraw patterns predicted negative emotions and tactics during marital interactions and lower levels of conflict resolution. Spousal depression was linked to increased likelihood of husband demand-wife withdraw.

Estimated use of water in the Delaware River Basin in Delaware, New Jersey, New York, and Pennsylvania, 2010

Science.gov (United States)

Hutson, Susan S.; Linsey, Kristin S.; Ludlow, Russell A.; Reyes, Betzaida; Shourds, Jennifer L.

2016-11-07

water withdrawn was freshwater. Total groundwater withdrawals were calculated to be 545 Mgal/d (8 percent of the total), all of which was freshwater. During 2010, calculated withdrawals by category, in decreasing order, were: thermoelectric power, 4,910 Mgal/d; public supply, 1,490 Mgal/d; self-supplied industrial, 350 Mgal/d; irrigation, 175 Mgal/d; self-supplied domestic, 117 Mgal/d; mining, 41.3 Mgal/d; aquaculture, 19.3 Mgal/d; livestock, 6.72 Mgal/d, and commercial, 5.89 Mgal/d. The amount of instream use for hydroelectric power generation purposes in 2010 was reported to be 273 Mgal/d for the Wallenpaupack Plant and 127 Mgal/d for the Mongaup River system.Total return flows in the DRB were 2,960 Mgal/d in 2010. Although municipal wastewater-treatment plants accounted for 539 (97 percent) of the return-flow sites, they accounted for about 70 percent of the total return flows in the DRB. There was limited information on return flows from thermoelectric power.

Modeling of fluid injection and withdrawal induced fault activation using discrete element based hydro-mechanical and dynamic coupled simulator

Science.gov (United States)

Yoon, Jeoung Seok; Zang, Arno; Zimmermann, Günter; Stephansson, Ove

2016-04-01

Operation of fluid injection into and withdrawal from the subsurface for various purposes has been known to induce earthquakes. Such operations include hydraulic fracturing for shale gas extraction, hydraulic stimulation for Enhanced Geothermal System development and waste water disposal. Among these, several damaging earthquakes have been reported in the USA in particular in the areas of high-rate massive amount of wastewater injection [1] mostly with natural fault systems. Oil and gas production have been known to induce earthquake where pore fluid pressure decreases in some cases by several tens of Mega Pascal. One recent seismic event occurred in November 2013 near Azle, Texas where a series of earthquakes began along a mapped ancient fault system [2]. It was studied that a combination of brine production and waste water injection near the fault generated subsurface pressures sufficient to induced earthquakes on near-critically stressed faults. This numerical study aims at investigating the occurrence mechanisms of such earthquakes induced by fluid injection [3] and withdrawal by using hydro-geomechanical coupled dynamic simulator (Itasca's Particle Flow Code 2D). Generic models are setup to investigate the sensitivity of several parameters which include fault orientation, frictional properties, distance from the injection well to the fault, amount of fluid withdrawal around the injection well, to the response of the fault systems and the activation magnitude. Fault slip movement over time in relation to the diffusion of pore pressure is analyzed in detail. Moreover, correlations between the spatial distribution of pore pressure change and the locations of induced seismic events and fault slip rate are investigated. References [1] Keranen KM, Weingarten M, Albers GA, Bekins BA, Ge S, 2014. Sharp increase in central Oklahoma seismicity since 2008 induced by massive wastewater injection, Science 345, 448, DOI: 10.1126/science.1255802. [2] Hornbach MJ, DeShon HR

Acupuncture for alcohol withdrawal: a randomized controlled trial.

Science.gov (United States)

Trümpler, François; Oez, Suzan; Stähli, Peter; Brenner, Hans Dieter; Jüni, Peter

2003-01-01

Previous trials on acupuncture in alcohol addiction were in outpatients and focused on relapse prevention. Rates of dropout were high and interpretation of results difficult. We compared auricular laser and needle acupuncture with sham laser stimulation in reducing the duration of alcohol withdrawal. Inpatients undergoing alcohol withdrawal were randomly allocated to laser acupuncture (n = 17), needle acupuncture (n = 15) or sham laser stimulation (n = 16). Attempts were made to blind patients, therapists and outcome assessors, but this was not feasible for needle acupuncture. The duration of withdrawal symptoms (as assessed using a nurse-rated scale) was the primary outcome; the duration of sedative prescription was the secondary outcome. Patients randomized to laser and sham laser had identical withdrawal symptom durations (median 4 days). Patients randomized to needle stimulation had a shorter duration of withdrawal symptoms (median 3 days; P = 0.019 versus sham intervention), and tended to have a shorter duration of sedative use, but these differences diminished after adjustment for baseline differences. The data from this pilot trial do not suggest a relevant benefit of auricular laser acupuncture for alcohol withdrawal. A larger trial including adequate sham interventions is needed, however, to reliably determine the effectiveness of any type of auricular acupuncture in this condition.

Multi-objective analysis of the conjunctive use of surface water and groundwater in a multisource water supply system

Science.gov (United States)

Vieira, João; da Conceição Cunha, Maria

2017-04-01

A multi-objective decision model has been developed to identify the Pareto-optimal set of management alternatives for the conjunctive use of surface water and groundwater of a multisource urban water supply system. A multi-objective evolutionary algorithm, Borg MOEA, is used to solve the multi-objective decision model. The multiple solutions can be shown to stakeholders allowing them to choose their own solutions depending on their preferences. The multisource urban water supply system studied here is dependent on surface water and groundwater and located in the Algarve region, southernmost province of Portugal, with a typical warm Mediterranean climate. The rainfall is low, intermittent and concentrated in a short winter, followed by a long and dry period. A base population of 450 000 inhabitants and visits by more than 13 million tourists per year, mostly in summertime, turns water management critical and challenging. Previous studies on single objective optimization after aggregating multiple objectives together have already concluded that only an integrated and interannual water resources management perspective can be efficient for water resource allocation in this drought prone region. A simulation model of the multisource urban water supply system using mathematical functions to represent the water balance in the surface reservoirs, the groundwater flow in the aquifers, and the water transport in the distribution network with explicit representation of water quality is coupled with Borg MOEA. The multi-objective problem formulation includes five objectives. Two objective evaluate separately the water quantity and the water quality supplied for the urban use in a finite time horizon, one objective calculates the operating costs, and two objectives appraise the state of the two water sources - the storage in the surface reservoir and the piezometric levels in aquifer - at the end of the time horizon. The decision variables are the volume of withdrawals from

45 CFR 400.301 - Withdrawal from the refugee program.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Withdrawal from the refugee program. 400.301... Waivers and Withdrawals § 400.301 Withdrawal from the refugee program. (a) In the event that a State... assistance, social services, preventive health, and an unaccompanied minors program if appropriate. A State...

Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice

Directory of Open Access Journals (Sweden)

Vikas Seth

2010-01-01

Full Text Available The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced by using an opioid antagonist, naloxone. Mice were observed for 30 minutes for the withdrawal signs ie, the characteristic jumping, hyperactivity, urination and diarrhea. ATP-dependent potassium (K + ATP channel modulators were injected intraperitoneally (i.p. 30 minutes before the naloxone. It was found that a K + ATP channel opener, minoxidil (12.5–50 mg/kg i.p., suppressed the morphine withdrawal significantly. On the other hand, the K + ATP channel blocker glibenclamide (12.5–50 mg/kg i.p. caused a significant facilitation of the withdrawal. Glibenclamide was also found to abolish the minoxidil's inhibitory effect on morphine withdrawal. The study concludes that K + ATP channels play an important role in the genesis of morphine withdrawal and K + ATP channel openers could be useful in the management of opioid withdrawal. As morphine opens K + ATP channels in neurons, the channel openers possibly act by mimicking the effects of morphine on neuronal K + currents.

Managing acute alcohol withdrawal with Homoeopathy: A prospective, observational, multicentre exploratory study

Directory of Open Access Journals (Sweden)

Debadatta Nayak

2014-01-01

Full Text Available Background: Alcohol dependence is a common social problem which may be associated with other risk factors and co-morbidities. Abrupt cessation of alcohol intake may provoke an acute alcohol withdrawal phase with varying degrees of signs and symptoms. In conventional medical system, specific pharmacological interventions are used for management of Acute Alcohol Withdrawal (AAW. There exists a need to explore safe and holistic treatment of AAW. The present work reports the results of a prospective, observational, exploratory, multicentre trial (2008-2011 to assess the role of Homoeopathy in AAW. Materials and Methods: Individualised Homoeopathy was given to 112 patients reporting with AAW. The clinical assessment was done for 05 days using Clinical Institute Withdrawal Assessment Scale of Alcohol-Revised (CIWA-Ar. Post-withdrawal phase, quality of life of patients was assessed at end of 01 st , 03 rd and 06 th month using World Health Organisation quality of life (WHOQOL- BREF. Results and Analysis: There was a significant decrease in CIWA-Ar mean scores and increase in quality of life score (P < 0.001. The most common remedies used were Arsenicum album, Lycopodium clavatum, Belladonna, Nux vomica and Pulsatilla. Conclusion: The results of current observational pilot study suggest the promising use of Homoeopathy in the management of acute alcohol withdrawal. Further studies with large sample size and rigorous design are warranted.

A psychometric validation of the Short Alcohol Withdrawal Scale (SAWS)

DEFF Research Database (Denmark)

Elholm, Bjarne; Larsen, Klaus; Hornnes, Nete

2010-01-01

The study aimed to evaluate psychometrically a Danish translation of the Short Alcohol Withdrawal Scale (SAWS) in an outpatient setting in patients with Alcohol Dependence (AD) and Alcohol Withdrawal Symptoms/Syndrome (AWS).......The study aimed to evaluate psychometrically a Danish translation of the Short Alcohol Withdrawal Scale (SAWS) in an outpatient setting in patients with Alcohol Dependence (AD) and Alcohol Withdrawal Symptoms/Syndrome (AWS)....

[The effect of palonosetron on rocuronium-induced withdrawal movement].

Science.gov (United States)

Park, Ki-Bum; Jeon, Younghoon; Yi, Junggu; Kim, Ji-Hyun; Chung, Seung-Yeon; Kwak, Kyung-Hwa

Rocuronium causes pain and withdrawal movement during induction of anesthesia. In this study, palonosetron was investigated to have analgesic effect on the reduction of rocuronium-induced withdrawal movement. 120 patients were randomly assigned to one of three groups to receive either saline, lidocaine 20mg, or palonosetron 0.075mg with a tourniquet applied two minutes before thiopental sodium (5mg.kg -1 ) was given intravenously. After loss of consciousness, rocuronium (0.6mg.kg -1 ) was injected and the withdrawal movement was estimated by 4-point scale in a double-blind manner. The overall incidence of rocuronium withdrawal movement was 50% with lidocaine (p=0.038), 38% with palonosetron (p=0.006) compared with 75% for saline. The incidence of no pain to mild pain was significantly lower in the lidocaine and palonosetron groups (85% and 92% respectively) than in the saline group (58%). However, there was no significant difference in withdrawal movement between the lidocaine and palonosetron groups. There was no severe movement with palonosetron. Pretreatment of palonosetron with venous occlusion may attenuate rocuronium-induced withdrawal movement as effective as the use of lidocaine. It suggested that peripheral action of palonosetron was effective to reduce rocuronium-induced withdrawal movement. Copyright © 2016. Publicado por Elsevier Editora Ltda.

[Treatment of gamma-hydroxybutyrate withdrawal].

Science.gov (United States)

Strand, Niels August Willer; Petersen, Tonny Studsgaard; Nielsen, Lars Martin; Boegevig, Soren

2017-12-11

Gamma-hydroxybutyrate (GHB) is a drug of abuse, for which physical addiction develops quickly. GHB withdrawal can develop into a life-threatening condition and has previously been treated mainly with benzodiazepines. These have not always proven effective, leading to long hospitalizations in intensive care units. Based on successful Dutch treatment results for using GHB to treat GHB withdrawal symptoms, we propose to implement a similar method in Denmark. The method requires an interdisciplinary effort for which The Danish Poison Information Centre should be consulted for expertise.

21 CFR 171.7 - Withdrawal of petition without prejudice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Withdrawal of petition without prejudice. 171.7... Withdrawal of petition without prejudice. (a) In some cases the Commissioner will notify the petitioner that... clarification or the obtaining of additional data. This withdrawal will be without prejudice to a future filing...

21 CFR 571.7 - Withdrawal of petition without prejudice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Withdrawal of petition without prejudice. 571.7... Withdrawal of petition without prejudice. (a) In some cases the Commissioner will notify the petitioner that... clarification or the obtaining of additional data. This withdrawal will be without prejudice to a future filing...

The Water-Use Implications of a Changing Power Sector

Science.gov (United States)

Peer, R.; Sanders, K.

2016-12-01

Changing policies, declining natural gas prices due to shale production and, growing pressure for cleaner energy sources are causing significant shifts in the fuels and technologies utilized for US electricity generation. These shifts have already impacted the volumes of water required for cooling thermal power plants, imposing consequences for watersheds that have yet to be quantified. This research investigates how these regulatory, economic, and socially-driven changes in the power sector have impacted cooling water usage across the US, which currently represents nearly half of US water withdrawals. This study uses plant-specific fuel consumption, generation, and cooling water data to assess water usage trends in the power sector from 2008 to 2014 across HUC-8 hydrologic units. Over this period, transitions from steam-cycle coal and nuclear units towards combined-cycle natural gas units and renewables, as well as transitions from once-through cooling towards wet recirculating tower and dry cooling systems resulted in large shifts in water usage. Trends towards non-traditional cooling water sources such as recycled water reduced freshwater consumption in some watersheds. Although US cooling water withdrawals and consumption increased from 2008 to 2014 largely due to electricity demand growth, the average water withdrawn and consumed per unit of electricity generated decreased and remained similar in magnitude, respectively. Changes at the watershed scale were not uniform, with some experiencing significant water use reductions and environmental benefits, especially due to coal-fired power plant retirements. Results highlight the importance of evaluating both water withdrawals and consumption at local spatial scales, as these shifts have varying consequences on water availability and quality for downstream users and ecosystems. This analysis underscores the importance of prioritizing local water security in global climate change adaptation and mitigation efforts.

Water use at pulverized coal power plants with postcombustion carbon capture and storage.

Science.gov (United States)

Zhai, Haibo; Rubin, Edward S; Versteeg, Peter L

2011-03-15

Coal-fired power plants account for nearly 50% of U.S. electricity supply and about a third of U.S. emissions of CO(2), the major greenhouse gas (GHG) associated with global climate change. Thermal power plants also account for 39% of all freshwater withdrawals in the U.S. To reduce GHG emissions from coal-fired plants, postcombustion carbon capture and storage (CCS) systems are receiving considerable attention. Current commercial amine-based capture systems require water for cooling and other operations that add to power plant water requirements. This paper characterizes and quantifies water use at coal-burning power plants with and without CCS and investigates key parameters that influence water consumption. Analytical models are presented to quantify water use for major unit operations. Case study results show that, for power plants with conventional wet cooling towers, approximately 80% of total plant water withdrawals and 86% of plant water consumption is for cooling. The addition of an amine-based CCS system would approximately double the consumptive water use of the plant. Replacing wet towers with air-cooled condensers for dry cooling would reduce plant water use by about 80% (without CCS) to about 40% (with CCS). However, the cooling system capital cost would approximately triple, although costs are highly dependent on site-specific characteristics. The potential for water use reductions with CCS is explored via sensitivity analyses of plant efficiency and other key design parameters that affect water resource management for the electric power industry.

Current and future groundwater withdrawals: Effects, management and energy policy options for a semi-arid Indian watershed

Science.gov (United States)

Sishodia, Rajendra P.; Shukla, Sanjay; Graham, Wendy D.; Wani, Suhas P.; Jones, James W.; Heaney, James

2017-12-01

Effects of future expansion/intensification of irrigated agriculture on groundwater and surface water levels and availability in a semi-arid watershed were evaluated using an integrated hydrologic model (MIKE SHE/MIKE 11) in conjunction with biophysical measurements. Improved water use efficiency, water storage, and energy policy options were evaluated for their ability to sustain the future (2035) increased groundwater withdrawals. Three future withdrawal scenarios (low = 20, medium = 30, high = 50 wells/100 km2/year) based on the historical rate of growth of irrigation wells were formulated. While well drying from falling groundwater levels was limited to drought and consecutive below average rainfall years, under the current (2015) withdrawals, significant increases in frequency and duration (17-97 days/year) of well drying along with 13-26% (19-37 mm) reductions in surface flows were predicted under the future withdrawals. Higher (27-108%) energy demands of existing irrigation pumps due to declining groundwater levels and reduced hydroelectric generation due to decreased surface flows would create a vicious water-food-energy nexus in the future. Crop failure, one of the main causes of farmers' emotional distress and death in the region, is predicted to exacerbate under the future withdrawal scenarios. Shift to negative net recharge (-63 mm) and early and prolonged drying of wells under the high scenario will reduce the groundwater availability and negatively affect crop production in more than 60% and 90% of cropped areas in the Rabi (November-February) and summer (March-May) seasons, respectively during a drought year. Individual and combined demand (drip irrigation and reduced farm electricity subsidy) and supply (water storage) management options improved groundwater levels and reduced well drying by 55-97 days/year compared to business-as-usual management under the high scenario. The combined management (50% drip conversion, 50% reduction in subsidy, and

Water Stress from High-Volume Hydraulic Fracturing Potentially Threatens Aquatic Biodiversity and Ecosystem Services in Arkansas, United States.

Science.gov (United States)

Entrekin, Sally; Trainor, Anne; Saiers, James; Patterson, Lauren; Maloney, Kelly; Fargione, Joseph; Kiesecker, Joseph; Baruch-Mordo, Sharon; Konschnik, Katherine; Wiseman, Hannah; Nicot, Jean-Philippe; Ryan, Joseph N

2018-02-20

Demand for high-volume, short duration water withdrawals could create water stress to aquatic organisms in Fayetteville Shale streams sourced for hydraulic fracturing fluids. We estimated potential water stress using permitted water withdrawal volumes and actual water withdrawals compared to monthly median, low, and high streamflows. Risk for biological stress was considered at 20% of long-term median and 10% of high- and low-flow thresholds. Future well build-out projections estimated potential for continued stress. Most water was permitted from small, free-flowing streams and "frack" ponds (dammed streams). Permitted 12-h pumping volumes exceeded median streamflow at 50% of withdrawal sites in June, when flows were low. Daily water usage, from operator disclosures, compared to median streamflow showed possible water stress in 7-51% of catchments from June-November, respectively. If 100% of produced water was recycled, per-well water use declined by 25%, reducing threshold exceedance by 10%. Future water stress was predicted to occur in fewer catchments important for drinking water and species of conservation concern due to the decline in new well installations and increased use of recycled water. Accessible and precise withdrawal and streamflow data are critical moving forward to assess and mitigate water stress in streams that experience high-volume withdrawals.

Water stress from high-volume hydraulic fracturing potentially threatens aquatic biodiversity and ecosystem services in Arkansas, United States

Science.gov (United States)

Entrekin, Sally; Trainor, Anne; Saiers, James; Patterson, Lauren; Maloney, Kelly O.; Fargione, Joseph; Kiesecker, Joseph M.; Baruch-Mordo, Sharon; Konschnik, Katherine E.; Wiseman, Hannah; Nicot, Jean-Philippe; Ryan, Joseph N.

2018-01-01

Demand for high-volume, short duration water withdrawals could create water stress to aquatic organisms in Fayetteville Shale streams sourced for hydraulic fracturing fluids. We estimated potential water stress using permitted water withdrawal volumes and actual water withdrawals compared to monthly median, low, and high streamflows. Risk for biological stress was considered at 20% of long-term median and 10% of high- and low-flow thresholds. Future well build-out projections estimated potential for continued stress. Most water was permitted from small, free-flowing streams and “frack” ponds (dammed streams). Permitted 12-h pumping volumes exceeded median streamflow at 50% of withdrawal sites in June, when flows were low. Daily water usage, from operator disclosures, compared to median streamflow showed possible water stress in 7–51% of catchments from June–November, respectively. If 100% of produced water was recycled, per-well water use declined by 25%, reducing threshold exceedance by 10%. Future water stress was predicted to occur in fewer catchments important for drinking water and species of conservation concern due to the decline in new well installations and increased use of recycled water. Accessible and precise withdrawal and streamflow data are critical moving forward to assess and mitigate water stress in streams that experience high-volume withdrawals.

Development of water demand coefficients for power generation from renewable energy technologies

International Nuclear Information System (INIS)

Ali, Babkir; Kumar, Amit

2017-01-01

Highlights: • Water consumption and withdrawals coefficients for renewable power generation were developed. • Six renewable energy sources (biomass, nuclear, solar, wind, hydroelectricity, and geothermal) were studied. • Life cycle water footprints for 60 electricity generation pathways were considered. • Impact of cooling systems for some power generation pathways was assessed. - Abstract: Renewable energy technology-based power generation is considered to be environmentally friendly and to have a low life cycle greenhouse gas emissions footprint. However, the life cycle water footprint of renewable energy technology-based power generation needs to be assessed. The objective of this study is to develop life cycle water footprints for renewable energy technology-based power generation pathways. Water demand is evaluated through consumption and withdrawals coefficients developed in this study. Sixty renewable energy technology-based power generation pathways were developed for a comprehensive comparative assessment of water footprints. The pathways were based on the use of biomass, nuclear, solar, wind, hydroelectricity, and geothermal as the source of energy. During the complete life cycle, power generation from bio-oil extracted from wood chips, a biomass source, was found to have the highest water demand footprint and wind power the lowest. During the complete life cycle, the water demand coefficients for biomass-based power generation pathways range from 260 to 1289 l of water per kilowatt hour and for nuclear energy pathways from 0.48 to 179 l of water per kilowatt hour. The water demand for power generation from solar energy-based pathways ranges from 0.02 to 4.39 l of water per kilowatt hour, for geothermal pathways from 0.04 to 1.94 l of water per kilowatt hour, and for wind from 0.005 to 0.104 l of water per kilowatt hour. A sensitivity analysis was conducted with varying conversion efficiencies to evaluate the impact of power plant performance on

Narp regulates long-term aversive effects of morphine withdrawal

Science.gov (United States)

Reti, Irving M.; Crombag, Hans S.; Takamiya, Kogo; Sutton, Jeffrey M.; Guo, Ning; Dinenna, Megan L.; Huganir, Richard L.; Holland, Peter C.; Baraban, Jay M.

2008-01-01

Although long-lasting effects of drug withdrawal are thought to play a key role in motivating continued drug use, the mechanisms mediating this type of drug-induced plasticity are unclear. As Narp is an immediate early gene product that is secreted at synaptic sites and binds to AMPA receptors, it has been implicated in mediating enduring forms of synaptic plasticity. In previous studies, we found that Narp is selectively induced by morphine withdrawal in the extended amygdala, a group of limbic nuclei that mediate aversive behavioral responses. Accordingly, in this study, we evaluated whether long-term aversive effects of morphine withdrawal are altered in Narp KO mice. We found that acute physical signs of morphine withdrawal are unaffected by Narp deletion. However, Narp KO mice acquire and sustain more aversive responses to the environment conditioned with morphine withdrawal than WT controls. Paradoxically, Narp KO mice undergo accelerated extinction of this heightened aversive response. Taken together, these studies suggest that Narp modulates both acquisition and extinction of aversive responses to morphine withdrawal and, therefore, may regulate plasticity processes underlying drug addiction. PMID:18729628

A case of rhabdomyolysis associated with severe opioid withdrawal.

Science.gov (United States)

Gangahar, Deepali

2015-08-01

While the risk of opioid overdose is widely accepted, the dangers of opioid withdrawal are far less clearly defined. The purpose of this publication is to provide evidence against the erroneous clinical dictum that opioid withdrawal is never life-threatening. This case report (N = 1) illustrates an unfortunate, common scenario of a man abusing prescription opioids and heroin. His attempt at self-detoxification with buprenorphine-naloxone resulted in life-threatening opioid withdrawal. A detailed account of each day of his withdrawal period was documented by patient and family report and review of all medical records. The patient was contacted three months after hospitalization to verify information and determine progress in treatment and abstinence from drugs and alcohol. A review of the literature was completed on severe cases of precipitated and spontaneous opioid withdrawal followed by a discussion of the significance as it relates to this case. Given the widespread use of prescription opioids and opioid maintenance treatment, physicians should be aware of the complications of acute opioid withdrawal and should be equipped to treat these complications. © American Academy of Addiction Psychiatry.

Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats.

Directory of Open Access Journals (Sweden)

Maurício dos Santos Pereira

Full Text Available Methylphenidate (MPD is one of the most prescribed drugs for alleviating the symptoms of Attention Deficit/Hyperactivity Disorder (ADHD. However, changes in the molecular mechanisms related to MPD withdrawal and susceptibility to consumption of other psychostimulants in normal individuals or individuals with ADHD phenotype are not completely understood. The aims of the present study were: (i to characterize the molecular differences in the prefrontal dopaminergic system of SHR and Wistar strains, (ii to establish the neurochemical consequences of short- (24 hours and long-term (10 days MPD withdrawal after a subchronic treatment (30 days with Ritalin® (Methylphenidate Hydrochloride; 2.5 mg/kg orally, (iii to investigate the dopaminergic synaptic functionality after a cocaine challenge in adult MPD-withdrawn SHR and Wistar rats. Our results indicate that SHR rats present reduced [3H]-Dopamine uptake and cAMP accumulation in the prefrontal cortex (PFC and are not responsive to dopaminergic stimuli in when compared to Wistar rats. After a 24-hour withdrawal of MPD, SHR did not present any alterations in [3H]-Dopamine Uptake, [3H]-SCH 23390 binding and cAMP production; nonetheless, after a 10-day MPD withdrawal, the results showed a significant increase of [3H]-Dopamine uptake, of the quantity of [3H]-SCH 23390 binding sites and of cAMP levels in these animals. Finally, SHR that underwent a 10-day MPD withdrawal and were challenged with cocaine (10 mg/kg i.p. presented reduced [3H]-Dopamine uptake and increased cAMP production. Wistar rats were affected by the 10-day withdrawal of MPD in [3H]-dopamine uptake but not in cAMP accumulation; in addition, cocaine was unable to induce significant modifications in [3H]-dopamine uptake and in cAMP levels after the 10-day withdrawal of MPD. These results indicate a mechanism that could explain the high comorbidity between ADHD adolescent patients under methylphenidate treatment and substance abuse in adult

Depletion and capture: revisiting "the source of water derived from wells".

Science.gov (United States)

Konikow, L F; Leake, S A

2014-09-01

A natural consequence of groundwater withdrawals is the removal of water from subsurface storage, but the overall rates and magnitude of groundwater depletion and capture relative to groundwater withdrawals (extraction or pumpage) have not previously been well characterized. This study assesses the partitioning of long-term cumulative withdrawal volumes into fractions derived from storage depletion and capture, where capture includes both increases in recharge and decreases in discharge. Numerical simulation of a hypothetical groundwater basin is used to further illustrate some of Theis' (1940) principles, particularly when capture is constrained by insufficient available water. Most prior studies of depletion and capture have assumed that capture is unconstrained through boundary conditions that yield linear responses. Examination of real systems indicates that capture and depletion fractions are highly variable in time and space. For a large sample of long-developed groundwater systems, the depletion fraction averages about 0.15 and the capture fraction averages about 0.85 based on cumulative volumes. Higher depletion fractions tend to occur in more arid regions, but the variation is high and the correlation coefficient between average annual precipitation and depletion fraction for individual systems is only 0.40. Because 85% of long-term pumpage is derived from capture in these real systems, capture must be recognized as a critical factor in assessing water budgets, groundwater storage depletion, and sustainability of groundwater development. Most capture translates into streamflow depletion, so it can detrimentally impact ecosystems. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

Indicators of streamflow alteration, habitat fragmentation, impervious cover, and water quality for Massachusetts stream basins

Science.gov (United States)

Weiskel, Peter K.; Brandt, Sara L.; DeSimone, Leslie A.; Ostiguy, Lance J.; Archfield, Stacey A.

2010-01-01

Massachusetts streams and stream basins have been subjected to a wide variety of human alterations since colonial times. These alterations include water withdrawals, treated wastewater discharges, construction of onsite septic systems and dams, forest clearing, and urbanization—all of which have the potential to affect streamflow regimes, water quality, and habitat integrity for fish and other aquatic biota. Indicators were developed to characterize these types of potential alteration for subbasins and groundwater contributing areas in Massachusetts. The potential alteration of streamflow by the combined effects of withdrawals and discharges was assessed under two water-use scenarios. Water-use scenario 1 incorporated publicly reported groundwater withdrawals and discharges, direct withdrawals from and discharges to streams, and estimated domestic-well withdrawals and septic-system discharges. Surface-water-reservoir withdrawals were excluded from this scenario. Water-use scenario 2 incorporated all the types of withdrawal and discharge included in scenario 1 as well as withdrawals from surface-water reservoirs—all on a long-term, mean annual basis. All withdrawal and discharge data were previously reported to the State for the 2000–2004 period, except domestic-well withdrawals and septic-system discharges, which were estimated for this study. The majority of the state’s subbasins and groundwater contributing areas were estimated to have relatively minor (less than 10 percent) alteration of streamflow under water-use scenario 1 (seasonally varying water use; no surface-water-reservoir withdrawals). However, about 12 percent of subbasins and groundwater contributing areas were estimated to have extensive alteration of streamflows (greater than 40 percent) in August; most of these basins were concentrated in the outer metropolitan Boston region. Potential surcharging of streamflow in August was most commonly indicated for main-stem river subbasins, although

49 CFR 450.16 - Withdrawal of delegation.

Science.gov (United States)

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Withdrawal of delegation. 450.16 Section 450.16... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS GENERAL Procedure for Delegation to Approval Authorities § 450.16 Withdrawal of delegation. (a) The Chief, Office of Operating and Environmental Standards (CG-522...

20 CFR 410.690 - Withdrawal of charges.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Withdrawal of charges. 410.690 Section 410.690 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969... Review, Finality of Decisions, and Representation of Parties § 410.690 Withdrawal of charges. If an...

CONSUMER'S RIGHT TO WITHDRAW

Directory of Open Access Journals (Sweden)

ANCA NICOLETA GHEORGHE

2013-05-01

Full Text Available The right of withdrawal (of a contract belongs to the consumer, and is an essential means for the improvement of regulations that protect the consumer.. Right of withdrawal is not a recent creation and is not even specific to the consumer field. He was previously recognized in civil and commercial law (without special regulation. The right to withdraw may even have as ground the parties will. Thus, based on the contractual freedom, the parties may agree that one of them has the right to terminate the contract unilaterally The possibility of unilateral denunciation of the contract, gives the consumer, added protection by being able to reflect the decision and to check how the trader fulfil its obligations. In this context, through its effects, the right of denunciation, forces the professional parties to conduct themselves as fair as possible to the consumer and to execute the contract properly. In the study of the consumer protection, the time of conclusion is essential because in this stage is manifested, the inequality between the consumer and professional. Thus, the lack of information, the major of products and activities, commercial practices, influence the formation of consumer will, preventing the expression of a freely and knowingly consent.

Groundwater, surface-water, and water-chemistry data, Black Mesa area, northeastern Arizona: 2011-2012

Science.gov (United States)

Macy, Jamie P.; Unema, Joel A.

2014-01-01

The Navajo (N) aquifer is an extensive aquifer and the primary source of groundwater in the 5,400-square-mile Black Mesa area in northeastern Arizona. Availability of water is an important issue in northeastern Arizona because of continued water requirements for industrial and municipal use by a growing population and because of low precipitation in the arid climate of the Black Mesa area. Precipitation in the area typically is between 6 and 14 inches per year. The U.S. Geological Survey water-monitoring program in the Black Mesa area began in 1971 and provides information about the long-term effects of groundwater withdrawals from the N aquifer for industrial and municipal uses. This report presents results of data collected as part of the monitoring program in the Black Mesa area from January 2011 to September 2012. The monitoring program includes measurements of (1) groundwater withdrawals, (2) groundwater levels, (3) spring discharge, (4) surface-water discharge, and (5) groundwater chemistry. In 2011, total groundwater withdrawals were 4,480 acre-ft, industrial withdrawals were 1,390 acre-ft, and municipal withdrawals were 3,090 acre-ft. Total withdrawals during 2011 were about 39 percent less than total withdrawals in 2005 because of Peabody Western Coal Company’s discontinued use of water to transport coal in a slurry. From 2010 to 2011 total withdrawals increased by 11 percent; industrial withdrawals increased by approximately 19 percent, and total municipal withdrawals increased by 8 percent. From 2011 to 2012, annually measured water levels in the Black Mesa area declined in 8 of 15 wells that were available for comparison in the unconfined areas of the N aquifer, and the median change was -0.1 feet. Water levels declined in 9 of 18 wells measured in the confined area of the aquifer. The median change for the confined area of the aquifer was 0.0 feet. From the prestress period (prior to 1965) to 2012, the median water-level change for 34 wells in both

Transient Analysis of a Gas-cooled Fast Reactor for Single Control Assembly Withdrawal

International Nuclear Information System (INIS)

Choi, Hangbok

2014-01-01

The Energy Multiplier Module (EMZ) system response has been evaluated for control assembly withdrawal transients. Currently the EM2 core is equipped with six cylindrical drum-type control assemblies in the reflector zone for excess reactivity control and power maneuvering during the operating core life. This study investigates the system response to the control assembly withdrawal accident with various rotational speeds and reactivity worth to determine feasible control assembly design requirements from the physics viewpoint. The simulations have been conducted for single control assembly withdrawal transients without scram by a gas-cooled reactor plant simulator, which is based on a simplified plant nodal model, including the point reactor kinetics, single channel core thermal-fluid model, and a turbo-machinery performance model. Simulations were conducted for the middle-of- cycle core, when the excess reactivity of the core is the highest. Control assembly withdrawal times were varied from 1 (runaway) to 180 sec and reactivity worth was varied from 100 to 400 pcm. For a single control assembly withdrawal, the simulation has shown that the peak fuel temperature is expected to be ~1820°C when the assembly worth is 200 pcm and the runaway time is 1 sec per 180 degree rotation. The peak temperature could be reduced to ~1780°C if the assembly is rotated out in a moderate speed such as 1 degree/sec. These peak temperatures give a thermal margin of 22 to 24% to the melting point of uranium carbide fuel. The results also indicate that the current design with a single control assembly worth of 314 pcm may need adjustments in the future design. (author)

Nest building is a novel method for indexing severity of alcohol withdrawal in mice.

Science.gov (United States)

Greenberg, G D; Huang, L C; Spence, S E; Schlumbohm, J P; Metten, P; Ozburn, A R; Crabbe, J C

2016-04-01

Withdrawal after chronic ethanol (EtOH) affects body temperature, goal-directed behavior and motor function in mice and increases general central nervous system excitability. Nest-building tests have been used to assay these states but to this point have not been employed as measures of EtOH withdrawal severity. We first refined nest-scoring methods using a genetically heterogeneous stock of mice (HS/Npt). Mice were then made physically dependent following three days of chronic EtOH vapor inhalation to produce average blood EtOH concentrations (BECs) of 1.89 mg/mL. EtOH withdrawal affected the progression of nest building over time when mice were tested 2-4 days after removal from three days of chronic exposure to EtOH. In a separate group of mice, chronic EtOH vapor inhalation (BECs 1.84 mg/mL) suppressed nest building over days 1-2 but not days 2-3 of withdrawal. In a following experiment, EtOH withdrawal dose-dependently slowed recovery of nest building for up to 32 h. Finally, we determined that long-lasting nest-building deficits extend to mice undergoing withdrawal from a high dose (4 g/kg) of acute EtOH. Sex differences for nest building were absent following EtOH exposure. In mice naïve to EtOH treatments, male mice had lower pre-test body temperatures and increased nest scores across a two-day testing period compared to females. These results suggest that nest building can be used to assess chronic and acute EtOH withdrawal severity in mice. Published by Elsevier B.V.

Water Accounting Plus for Water Resources Reporting and River Basin Planning

NARCIS (Netherlands)

Karimi, P.

2014-01-01

This thesis introduces Water Accounting Plus (WA+), which is a new framework designed to provide explicit spatial information on water depletion and net withdrawal processes in complex river basins. WA+ is a simple, yet comprehensive and understandable water accounting framework that provides a

Scenarios of bioenergy development impacts on regional groundwater withdrawals

Science.gov (United States)

Uden, Daniel R.; Allen, Craig R.; Mitchell, Rob B.; Guan, Qingfeng; McCoy, Tim D.

2013-01-01

Irrigation increases agricultural productivity, but it also stresses water resources (Huffaker and Hamilton 2007). Drought and the potential for drier conditions resulting from climate change could strain water supplies in landscapes where human populations rely on finite groundwater resources for drinking, agriculture, energy, and industry (IPCC 2007). For instance, in the North American Great Plains, rowcrops are utilized for livestock feed, food, and bioenergy production (Cassman and Liska 2007), and a large portion is irrigated with groundwater from the High Plains aquifer system (McGuire 2011). Under projected future climatic conditions, greater crop water use requirements and diminished groundwater recharge rates could make rowcrop irrigation less feasible in some areas (Rosenberg et al. 1999; Sophocleous 2005). The Rainwater Basin region of south central Nebraska, United States, is an intensively farmed and irrigated Great Plains landscape dominated by corn (Zea mays L.) and soybean (Glycine max L.) production (Bishop and Vrtiska 2008). Ten starch-based ethanol plants currently service the region, producing ethanol from corn grain (figure 1). In this study, we explore the potential of switchgrass (Panicum virgatum L.), a drought-tolerant alternative bioenergy feedstock, to impact regional annual groundwater withdrawals for irrigation under warmer and drier future conditions. Although our research context is specific to the Rainwater Basin and surrounding North American Great Plains, we believe the broader research question is internationally pertinent and hope that this study simulates similar research in other areas.

Quantification and Multi-purpose Allocation of Water Resources in a Dual-reservoir System

Science.gov (United States)

Salami, Y. D.

2017-12-01

Transboundary rivers that run through separate water management jurisdictions sometimes experience competitive water usage. Where the river has multiple existing or planned dams along its course, quantification and efficient allocation of water for such purposes as hydropower generation, irrigation for agriculture, and water supply can be a challenge. This problem is even more pronounced when large parts of the river basin are located in semi-arid regions known for water insecurity, poor crop yields from irrigation scheme failures, and human population displacement arising from water-related conflict. This study seeks to mitigate the impacts of such factors on the Kainji-Jebba dual-reservoir system located along the Niger River in Africa by seasonally quantifying and efficiently apportioning water to all stipulated uses of both dams thereby improving operational policy and long-term water security. Historical storage fluctuations (18 km3 to 5 km3) and flows into and out of both reservoirs were analyzed for relationships to such things as surrounding catchment contribution, dam operational policies, irrigation and hydropower requirements, etc. Optimum values of the aforementioned parameters were then determined by simulations based upon hydrological contributions and withdrawals and worst case scenarios of natural and anthropogenic conditions (like annual probability of reservoir depletion) affecting water availability and allocation. Finally, quantification and optimized allocation of water was done based on needs for hydropower, irrigation for agriculture, water supply, and storage evacuation for flood control. Results revealed that water supply potential increased by 69%, average agricultural yield improved by 36%, and hydropower generation increased by 54% and 66% at the upstream and downstream dams respectively. Lessons learned from this study may help provide a robust and practical means of water resources management in similar river basins and multi

Opioid antagonists with minimal sedation for opioid withdrawal.

Science.gov (United States)

Gowing, Linda; Ali, Robert; White, Jason M

2017-05-29

Managed withdrawal is a necessary step prior to drug-free treatment or as the endpoint of long-term substitution treatment. To assess the effects of opioid antagonists plus minimal sedation for opioid withdrawal. Comparators were placebo as well as more established approaches to detoxification, such as tapered doses of methadone, adrenergic agonists, buprenorphine and symptomatic medications. We updated our searches of the following databases to December 2016: CENTRAL, MEDLINE, Embase, PsycINFO and Web of Science. We also searched two trials registers and checked the reference lists of included studies for further references to relevant studies. We included randomised and quasi-randomised controlled clinical trials along with prospective controlled cohort studies comparing opioid antagonists plus minimal sedation versus other approaches or different opioid antagonist regimens for withdrawal in opioid-dependent participants. We used standard methodological procedures expected by Cochrane. Ten studies (6 randomised controlled trials and 4 prospective cohort studies, involving 955 participants) met the inclusion criteria for the review. We considered 7 of the 10 studies to be at high risk of bias in at least one of the domains we assessed.Nine studies compared an opioid antagonist-adrenergic agonist combination versus a treatment regimen based primarily on an alpha 2 -adrenergic agonist (clonidine or lofexidine). Other comparisons (placebo, tapered doses of methadone, buprenorphine) made by included studies were too diverse for any meaningful analysis. This review therefore focuses on the nine studies comparing an opioid antagonist (naltrexone or naloxone) plus clonidine or lofexidine versus treatment primarily based on clonidine or lofexidine.Five studies took place in an inpatient setting, two studies were in outpatients with day care, two used day care only for the first day of opioid antagonist administration, and one study described the setting as outpatient

Gradual withdrawal of remifentanil infusion may prevent opioid-induced hyperalgesia.

Science.gov (United States)

Comelon, M; Raeder, J; Stubhaug, A; Nielsen, C S; Draegni, T; Lenz, H

2016-04-01

The aim of this study was to examine if gradual withdrawal of remifentanil infusion prevented opioid-induced hyperalgesia (OIH) as opposed to abrupt withdrawal. OIH duration was also evaluated. Nineteen volunteers were enrolled in this randomized, double-blinded, placebo-controlled, crossover study. All went through three sessions: abrupt or gradual withdrawal of remifentanil infusion and placebo. Remifentanil was administered at 2.5 ng ml(-1) for 30 min before abrupt withdrawal or gradual withdrawal by 0.6 ng ml(-1) every five min. Pain was assessed at baseline, during infusion, 45-50 min and 105-110 min after end of infusions using the heat pain test (HPT) and the cold pressor test (CPT). The HPT 45 min after infusion indicated OIH development in the abrupt withdrawal session with higher pain scores compared with the gradual withdrawal and placebo sessions (both Pwithdrawal compared with placebo (P=0.93). In the CPT 50 min after end of infusion there was OIH in both remifentanil sessions compared with placebo (gradual P=0.01, abrupt Pwithdrawal of remifentanil infusion in the HPT. After abrupt withdrawal OIH was present in the HPT. In the CPT there was OIH after both gradual and abrupt withdrawal of infusion. The duration of OIH was less than 105 min for both pain modalities. NCT 01702389. EudraCT number 2011-002734-39. © The Author 2016. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Two-day thionamide withdrawal prior to radioiodine uptake sufficiently increases uptake and does not exacerbate hyperthyroidism compared to 7-day withdrawal in Graves' disease

International Nuclear Information System (INIS)

Kubota, Sumihisa; Ohye, Hidemi; Yano, Genichiro; Nishihara, Eijun; Kudo, Takumi; Ito, Mitsuru; Fukata, Shuji; Amino, Nobuyuki; Kuma, Kanji; Miyauchi, Akira

2006-01-01

The appropriate period of antithyroid drug (ATD) discontinuation before radioiodine therapy is the most critical problem in Graves' disease patients under going treatment with ATD. To determine the optimal period that does not alter the outcome of radioiodine therapy or exacerbate hyperthyroidism, we compared serum FT4 levels at radioiodine uptake (RAIU) and therapy outcomes between a 2-day withdrawal group and 7-day withdrawal group. We prospectively recruited 43 patients for the 2-day withdrawal protocol and retrospectively reviewed 49 patients treated with radioiodine following the protocol of 7-day withdrawal. There was no significant difference in RAIU between the 2 groups. The mean serum FT4 level measured on the first day of 24-h RAIU of the 7-day group was significantly higher than that in the 2-day group. There were no significant differences in the outcomes at each point (6 months, 1 year, and 2 years after therapy) between the 2 groups. Our results indicated that withdrawal of ATD for 2 days is superior to 7 days in that 2 days discontinuation did not exacerbate hyperthyroidism. In order to prevent serum thyroid hormone increase after ATD withdrawal and radioiodine therapy, a 2-day ATD withdrawal period before radioiodine therapy may be useful for high-risk patients such as the elderly and patients with cardiac complications. We believe that the 2-day ATD withdrawal method may be useful for patients undergoing treatment with ATD who are to undergo radioiodine therapy. (author)

Acute coronary ischemia during alcohol withdrawal: a case report

Directory of Open Access Journals (Sweden)

Sriram Ganeshalingam

2011-08-01

Full Text Available Abstract Introduction The potential of alcohol withdrawal to cause acute coronary events is an area that needs the urgent attention of clinicians and researchers. Case presentation We report the case of a 52-year-old heavy-alcohol-using Sri Lankan man who developed electocardiogram changes suggestive of an acute coronary event during alcohol withdrawal. Despite the patient being asymptomatic, subsequent echocardiogram showed evidence of ischemic myocardial dysfunction. We review the literature on precipitation of myocardial ischemia during alcohol withdrawal and propose possible mechanisms. Conclusions Alcohol withdrawal is a commonly observed phenomenon in hospitals. However, the number of cases reported in the literature of acute coronary events occurring during withdrawal is few. Many cases of acute ischemia or sudden cardiac deaths may be attributed to other well known complications of delirium tremens. This is an area needing the urgent attention of clinicians and epidemiologists.

USA Withdrawal from Paris Agreement – What Next?

Directory of Open Access Journals (Sweden)

Sergey Chestnoy

2017-12-01

Full Text Available In June 2017, President Trump announced the USA’s withdrawal from the Paris Climate Accord, which had been ratified for less than a year, thanks in large part to the USA. That drastic shift followed the change in residency at the White House. Withdrawing from the Paris Accord presents an interesting topic for analysis. There’s the practical side of the withdrawal procedure as set out in Article 28 of the agreement, not to mention the consequences of US non-participation in addressing international climate issues. There are other international forums (Such as G8 and G20, which also have an interest in climate related topics. The Article analyses the U.S. position in negotiations and its commitments assumed the moment the United Nations Framework Convention on Climate Change (UNFCCC came into effect until now: the reduction of greenhouse gas emissions, financial aid and reporting. It also provides general analysis of national legal obligations under the Paris Accord, ratification of that agreement in general and in particularly another that took place in the USA, it focuses on the specifics of withdrawal. The specified three-year period from the Agreement becoming active, after which any party may withdraw from it (2019, is a noteworthy detail. It is well-known that the Paris Agreement provides a framework that does not impose individual national commitments or a commitment to a compliance system. In essence, and from a legal point of view, it is nonbinding. This was what allowed the USA to accept the terms of the accord relatively quickly and to use the simplified procedure, which by-passed Congress. In the opinion of the authors, President Trump’s resolution to withdraw should, possibly, be considered as a simple continuation of his election discourse and the fulfilment of a campaign promise. Additionally, President Trump’s declared intent to review the Paris Accord has legal grounds on which to launch further international negotiations

Groundwater, surface-water, and water-chemistry data, Black Mesa area, northeastern Arizona—2012–2013

Science.gov (United States)

Macy, Jamie P.; Truini, Margot

2016-03-02

The Navajo (N) aquifer is an extensive aquifer and the primary source of groundwater in the 5,400-square-mile Black Mesa area in northeastern Arizona. Availability of water is an important issue in northeastern Arizona because of continued water requirements for industrial and municipal use by a growing population and because of low precipitation in the arid climate of the Black Mesa area. Precipitation in the area typically is between 6 and 14 inches per year.The U.S. Geological Survey water-monitoring program in the Black Mesa area began in 1971 and provides information about the long-term effects of groundwater withdrawals from the N aquifer for industrial and municipal uses. This report presents results of data collected as part of the monitoring program in the Black Mesa area from January 2012 to September 2013. The monitoring program includes measurements of (1) groundwater withdrawals, (2) groundwater levels, (3) spring discharge, (4) surface-water discharge, and (5) groundwater chemistry.In calendar year 2012, total groundwater withdrawals were 4,010 acre-ft, industrial withdrawals were 1,370 acre-ft, and municipal withdrawals were 2,640 acre-ft. Total withdrawals during 2012 were about 45 percent less than total withdrawals in 2005 because of Peabody Western Coal Company’s discontinued use of water to transport coal in a coal slurry pipeline. From 2011 to 2012 total withdrawals decreased by 10 percent; industrial withdrawals decreased by approximately 1 percent, and total municipal withdrawals decreased by 15 percent.From 2012 to 2013, annually measured water levels in the Black Mesa area declined in 6 of 16 wells that were available for comparison in the unconfined areas of the N aquifer, and the median change was 0.8 feet. Water levels declined in 5 of 16 wells measured in the confined area of the aquifer. The median change for the confined area of the aquifer was 0.3 feet. From the prestress period (prior to 1965) to 2013, the median water

Stress Testing Water Resource Systems at Regional and National Scales with Synthetic Drought Event Sets

Science.gov (United States)

Hall, J. W.; Mortazavi-Naeini, M.; Coxon, G.; Guillod, B. P.; Allen, M. R.

2017-12-01

Water resources systems can fail to deliver the services required by water users (and deprive the environment of flow requirements) in many different ways. In an attempt to make systems more resilient, they have also been made more complex, for example through a growing number of large-scale transfers, optimized storages and reuse plants. These systems may be vulnerable to complex variants of hydrological variability in space and time, and behavioural adaptations by water users. In previous research we have used non-parametric stochastic streamflow generators to test the vulnerability of water resource systems. Here we use a very large ensemble of regional climate model outputs from the weather@home crowd-sourced citizen science project, which has generated more than 30,000 years of synthetic weather for present and future climates in the UK and western Europe, using the HadAM3P regional climate model. These simulations have been constructed in order to preserve prolonged drought characteristics, through treatment of long-memory processes in ocean circulations and soil moisture. The weather simulations have been propagated through the newly developed DynaTOP national hydrological for Britain, in order to provide low flow simulations at points of water withdrawal for public water supply, energy and agricultural abstractors. We have used the WATHNET water resource simulation model, set up for the Thames Basin and for all of the large water resource zones in England, to simulate the frequency, severity and duration of water shortages in all of these synthetic weather conditions. In particular, we have sought to explore systemic vulnerabilities associated with inter-basin transfers and the trade-offs between different water users. This analytical capability is providing the basis for (i) implementation of the Duty of Resilience, which has been placed upon the water industry in the 2014 Water Act and (ii) testing reformed abstraction arrangements which the UK government

Cannabis Withdrawal in Adults With Attention-Deficit/Hyperactivity Disorder.

Science.gov (United States)

Chauchard, Emeline; Hartwell, Karen J; McRae-Clark, Aimee L; Sherman, Brian J; Gorelick, David A

2018-02-22

Cannabis withdrawal has not been studied in adults with attention-deficit/hyperactivity disorder (ADHD) who have high rates of cannabis use. We aimed to describe cannabis withdrawal, motivations to quit, and strategies to quit cannabis use in cannabis-dependent adults with ADHD. Twenty-three adults with ADHD enrolled in a controlled clinical trial of pharmacotherapy (atomoxetine) for cannabis dependence (DSM-IV criteria) completed the Marijuana Quit Questionnaire (MJQQ) to provide information on their "most serious" quit attempt made without formal treatment. The study was conducted between November 2005 and June 2008. Participants were predominantly male (82.6%, n = 19), with a mean (SD) age of 27.4 (8.5) years (range, 18-53) at the start of their index quit attempt. The most common motive for quitting cannabis was "to save money" (87%, n = 20); the most common strategy to maintain abstinence was "stopped associating with people who smoke marijuana" (43%, n = 10). Almost all (96%, n = 22) subjects reported ≥ 1 cannabis withdrawal symptom; 7 (30%) met DSM-5 diagnostic criteria for cannabis withdrawal syndrome. Participants with comorbid ADHD and cannabis dependence reported withdrawal symptoms similar to other samples of non-treatment-seeking cannabis-dependent adults with no psychiatric comorbidity. These findings suggest that ADHD does not influence cannabis withdrawal in the way that it does tobacco (nicotine) withdrawal. Data used in this secondary analysis came from ClinicalTrials.gov identifier: NCT00360269. © Copyright 2018 Physicians Postgraduate Press, Inc.

40 CFR 97.86 - Withdrawal from NOX Budget Trading Program.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS Individual Unit Opt-ins. § 97.86 Withdrawal from NOX Budget Trading Program. (a) Requesting withdrawal. To...

42 CFR 8.6 - Withdrawal of approval of accreditation bodies.

Science.gov (United States)

2010-10-01

... PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Accreditation § 8.6 Withdrawal of approval of... 42 Public Health 1 2010-10-01 2010-10-01 false Withdrawal of approval of accreditation bodies. 8.6... to establish that the problems that were grounds for withdrawal of approval have been resolved. (2...

Massive intracerebral Epstein-Barr virus reactivation in lethal multiple sclerosis relapse after natalizumab withdrawal.

Science.gov (United States)

Serafini, Barbara; Scorsi, Eleonora; Rosicarelli, Barbara; Rigau, Valérie; Thouvenot, Eric; Aloisi, Francesca

2017-06-15

Rebound of disease activity in multiple sclerosis patients after natalizumab withdrawal is a potentially life-threatening event. To verify whether highly destructive inflammation after natalizumab withdrawal is associated with Epstein-Barr virus (EBV) reactivation in central nervous system infiltrating B-lineage cells and cytotoxic immunity, we analyzed post-mortem brain tissue from a patient who died during a fulminating MS relapse following natalizumab withdrawal. Numerous EBV infected B cells/plasma cells and CD8+ T cells infiltrated all white matter lesions; the highest frequency of EBV lytically infected cells and granzyme B+ CD8+ T cells was observed in actively demyelinating lesions. These results may encourage switching to B-cell depleting therapy after natalizumab discontinuation. Copyright © 2017 Elsevier B.V. All rights reserved.

Tobacco withdrawal symptoms mediate motivation to reinstate smoking during abstinence.

Science.gov (United States)

Aguirre, Claudia G; Madrid, Jillian; Leventhal, Adam M

2015-08-01

Withdrawal-based theories of addiction hypothesize that motivation to reinstate drug use following acute abstinence is mediated by withdrawal symptoms. Experimental tests of this hypothesis in the tobacco literature are scant and may be subject to methodological limitations. This study utilized a robust within-subject laboratory experimental design to investigate the extent to which composite tobacco withdrawal symptomatology level and 3 unique withdrawal components (i.e., low positive affect, negative affect, and urge to smoke) mediated the effect of smoking abstinence on motivation to reinstate smoking. Smokers (≥10 cigarettes per day; N = 286) attended 2 counterbalanced sessions at which abstinence duration was differentially manipulated (1 hr vs. 17 hr). At both sessions, participants reported current withdrawal symptoms and subsequently completed a task in which they were monetarily rewarded proportional to the length of time they delayed initiating smoking, with shorter latency reflecting stronger motivation to reinstate smoking. Abstinence reduced latency to smoking initiation and positive affect and increased composite withdrawal symptom level, urge, and negative affect. Abstinence-induced reductions in latency to initiating smoking were mediated by each withdrawal component, with stronger effects operating through urge. Combined analyses suggested that urge, negative affect, and low positive affect operate through empirically unique mediational pathways. Secondary analyses suggested similar effects on smoking quantity, few differences among specific urge and affect subtypes, and that dependence amplifies some abstinence effects. This study provides the first experimental evidence that within-person variation in abstinence impacts motivation to reinstate drug use through withdrawal. Urge, negative affect, and low positive affect may reflect unique withdrawal-mediated mechanisms underlying tobacco addiction. (c) 2015 APA, all rights reserved).

Analysis of core physics and thermal-hydraulics results of control rod withdrawal experiments in the LOFT facility

International Nuclear Information System (INIS)

Varacalle, D.J. Jr.; Chen, T.H.; Harvego, E.A.; Ollikkala, H.

1983-01-01

Two anticipated transient experiments simulating an uncontrolled control rod withdrawal event in a pressurized water reactor (PWR) were conducted in the Loss-of-Fluid Test (LOFT) Facility at the Idaho National Engineering Laboratory. The scaled LOFT 50-MW(t) PWR includes most of the principal features of larger commercial PWRs. The experiments tested the ability of reactor analysis codes to accurately calculate core reactor physics and thermal-hydraulic phenomena in an integral reactor system. The initial conditions and scaled operating parameters for the experiments were representative of those expected in a commercial PWR. In both experiments, all four LOFT control rod assemblies were withdrawn at a reactor power of 37.5 MW and a system pressure of 14.8 MPa

Social Withdrawal, Friendship, and Depressed Mood in Adolescents

NARCIS (Netherlands)

Aleva, A.E.|info:eu-repo/dai/nl/141299789; van Beek, Y.|info:eu-repo/dai/nl/107292300

2017-01-01

Social withdrawal in children may develop into a depressed mood in early adolescence , through experiences of problematic peer relationships, while friendship may function as a buffer (Rubin, Coplan, & Bowker, 2009). Our study examines the predictive relation between social withdrawal and depressive

Prolonged social withdrawal disorder: a hikikomori case in Spain.

Science.gov (United States)

Ovejero, Santiago; Caro-Cañizares, Irene; de León-Martínez, Victoria; Baca-Garcia, Enrique

2014-09-01

The Japanese term hikikomori means literally 'to be confined'. Social withdrawal can be present in severe psychiatric disorders; however, in Japan, hikikomori is a defined nosologic entity. There have been only a few reported cases in occidental culture. We present a case report of a Spanish man with prolonged social withdrawal lasting for 4 years. This is a case of prolonged social withdrawal not bound to culture, as well as the second case of hikikomori reported in Spain. We propose prolonged social withdrawal disorder as a disorder not linked to culture, in contrast to hikikomori. Further documentation of this disorder is still needed to encompass all cases reported in Japan and around the world. © The Author(s) 2013.

The impact of water use fees on dispatching and water requirements for water-cooled power plants in Texas.

Science.gov (United States)

Sanders, Kelly T; Blackhurst, Michael F; King, Carey W; Webber, Michael E

2014-06-17

We utilize a unit commitment and dispatch model to estimate how water use fees on power generators would affect dispatching and water requirements by the power sector in the Electric Reliability Council of Texas' (ERCOT) electric grid. Fees ranging from 10 to 1000 USD per acre-foot were separately applied to water withdrawals and consumption. Fees were chosen to be comparable in cost to a range of water supply projects proposed in the Texas Water Development Board's State Water Plan to meet demand through 2050. We found that these fees can reduce water withdrawals and consumption for cooling thermoelectric power plants in ERCOT by as much as 75% and 23%, respectively. To achieve these water savings, wholesale electricity generation costs might increase as much as 120% based on 2011 fuel costs and generation characteristics. We estimate that water saved through these fees is not as cost-effective as conventional long-term water supply projects. However, the electric grid offers short-term flexibility that conventional water supply projects do not. Furthermore, this manuscript discusses conditions under which the grid could be effective at "supplying" water, particularly during emergency drought conditions, by changing its operational conditions.

Alcohol withdrawal delirium manifested by manic symptoms in an elderly patient.

Science.gov (United States)

Chan, Hung-Yu; Lee, Kuan-I

2015-03-01

Alcohol withdrawal syndrome is a commonly seen problem in psychiatric practice. Alcohol withdrawal delirium is associated with significant morbidity and mortality. Withdrawal symptoms usually include tremulousness, psychotic and perceptual symptoms, seizures, and consciousness disturbance. Herein, we report a case involving a 63-year-old man who had alcohol withdrawal delirium that was manifested mainly by manic symptoms. © 2014 The Authors. Psychogeriatrics © 2014 Japanese Psychogeriatric Society.

Social Withdrawal and Maladjustment in a Very Group-Oriented Society

Science.gov (United States)

Valdivia, Ibis Alvarez; Schneider, Barry H.; Chavez, Kenia Lorenzo; Chen, Xinyin

2005-01-01

Elementary-school children in Cuba and Canada participated in measures of loneliness, sociometric status, friendship, aggression, and social withdrawal. Withdrawal was associated with loneliness in the Cuban data from both cohorts, Grade 4 and Grade 6. In the Canadian data, withdrawal was only linked to loneliness in Grade 6. In contrast with…

Demand-Withdraw Patterns in Marital Conflict in the Home

OpenAIRE

Papp, Lauren M.; Kouros, Chrystyna D.; Cummings, E. Mark

2009-01-01

The present study extended laboratory-based findings of demand-withdraw communication into marital conflict in the home and further explored its linkages with spousal depression. U.S. couples (N = 116) provided diary reports of marital conflict and rated depressive symptoms. Hierarchical linear modeling results indicated that husband demand-wife withdraw and wife demand-husband withdraw occurred in the home at equal frequency, and both were more likely to occur when discussing topics that con...

41 CFR 101-39.307 - Grounds for withdrawal of vehicle.

Science.gov (United States)

2010-07-01

... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Grounds for withdrawal of vehicle. 101-39.307 Section 101-39.307 Public Contracts and Property Management Federal Property...

An integrated assessment of energy-water nexus at the state level in the United States: Projections and analyses under different scenarios through 2095

Science.gov (United States)

Liu, L.; Patel, P. L.; Hejazi, M. I.; Kyle, P.; Davies, E. G.; Zhou, Y.; Clarke, L.; Edmonds, J.

2013-12-01

Water withdrawals for thermoelectric power plants account for approximately half of the total water use in the United States. With growing electricity demands in the future and limited water supplies in many water-scarce states in the U.S., grasping the trade-off between energy and water requires an integrated modeling approach that can capture the interactions among energy, water availability, climate, technology, and economic factors at various scales. In this study, the Global Change Assessment Model (GCAM), a technologically-detailed integrated model of the economy, energy, agriculture and land use, water, and climate systems, with 14 geopolitical regions that are further dissaggregated into up to 18 agro-ecological zones, was extended to model the electricity and water systems at the state level in the U.S. More specifically, GCAM was employed to estimate future state-level electricity generation and demands, and the associated water withdrawals and consumptions under a set of six scenarios with extensive levels of details on generation fuel portfolio, cooling technology mix, and water use intensities. The state-level estimates were compared against available inventories where good agreement was achieved on national and regional levels. We then explored the electric-sector water use up to 2095, focusing on implications from: 1) socioeconomics and growing demands, 2) the adoption of climate mitigation policy (e.g., RCP4.5 W/m2 vs. a reference scenario), 3) the transition of cooling systems, 4) constraints on electricity trading across states (full trading vs. limited trading), and 5) the adoption of water saving technologies. Overall, the fast retirement of once-through cooling, together with the gradual transition from fossil fuels dominant to a mixture of different fuels, accelerate the decline of water withdrawals and correspondingly compensate consumptive water use. Results reveal that U.S. electricity generation expands significantly as population grows

Provincial Water Resource Allocation in Agricultural Sector Using Conflict Resolution Methods in Atrak Basin

OpenAIRE

Parvaneh KazemiMeresht; Shahab Araghinejad

2017-01-01

Introduction: In spite of improving the water productivity due to development in water infrastructure systems, population increasing causing the water withdrawal is triple in the last fifty years. In this situation competition on water consumption especially in the agricultural sector which is the biggest consumer in the world and also in Iran is a severe problem. Water allocation has been assessed widely in the recent past. Additionally, several studies have explored methods to incorporate c...

Ethical Analysis of Withdrawing Total Artificial Heart Support.

Science.gov (United States)

DeMartino, Erin S; Wordingham, Sara E; Stulak, John M; Boilson, Barry A; Fuechtmann, Kayla R; Singh, Nausheen; Sulmasy, Daniel P; Pajaro, Octavio E; Mueller, Paul S

2017-05-01

To describe the characteristics of patients who undergo withdrawal of total artificial heart support and to explore the ethical aspects of withdrawing this life-sustaining treatment. We retrospectively reviewed the medical records of all adult recipients of a total artificial heart at Mayo Clinic from the program's inception in 2007 through June 30, 2015. Management of other life-sustaining therapies, approach to end-of-life decision making, engagement of ethics and palliative care consultation, and causes of death were analyzed. Of 47 total artificial heart recipients, 14 patients or their surrogates (30%) requested withdrawal of total artificial heart support. No request was denied by treatment teams. All 14 patients were supported with at least 1 other life-sustaining therapy. Only 1 patient was able to participate in decision making. It is widely held to be ethically permissible to withdraw a life-sustaining treatment when the treatment no longer meets the patient's health care-related goals (ie, the burdens outweigh the benefits). These data suggest that some patients, surrogates, physicians, and other care providers believe that this principle extends to the withdrawal of total artificial heart support. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Alcohol Withdrawal Mimicking Organophosphate Poisoning

Directory of Open Access Journals (Sweden)

Nezihat Rana Disel

2014-02-01

Full Text Available Organophosphates, which can cause occupational poisoning due to inappropriate personal protective measures, are widely used insecticides in agricultural regions of southern Turkey. Therefore, the classical clinical findings of this cholinergic poisoning are myosis, excessive secretions, bradicardia and fasciculations are easy to be recognized by local medical stuff. Diseases and conditions related to alcoholism such as mental and social impairments, coma, toxicity, withdrawal, and delirium are frequent causes of emergency visits of chronic alcoholic patients. Here we present a case diagnosed and treated as organophosphate poisoning although it was an alcohol withdrawal in the beginning and became delirium tremens, due to similar symptoms.

Groundwater, surface-water, and water-chemistry data, Black Mesa area, northeastern Arizona—2013–2015

Science.gov (United States)

Macy, Jamie P.; Mason, Jon P.

2017-12-07

The Navajo (N) aquifer is an extensive aquifer and the primary source of groundwater in the 5,400-square-mile Black Mesa area in northeastern Arizona. Availability of water is an important issue in northeastern Arizona because of continued water requirements for industrial and municipal use by a growing population and because of low precipitation in the arid climate of the Black Mesa area. Precipitation in the area typically is between 6 and 16 inches per year.The U.S. Geological Survey water-monitoring program in the Black Mesa area began in 1971 and provides information about the long-term effects of groundwater withdrawals from the N aquifer for industrial and municipal uses. This report presents results of data collected as part of the monitoring program in the Black Mesa area from January 2013 to December 2015. The monitoring program includes measurements of (1) groundwater withdrawals (pumping), (2) groundwater levels, (3) spring discharge, (4) surface-water discharge, and (5) groundwater chemistry.In 2013, total groundwater withdrawals were 3,980 acre-feet (ft), in 2014 total withdrawals were 4,170 acre-ft, and in 2015 total withdrawals were 3,970 acre-ft. From 2013 to 2015 total withdrawals varied by less than 5 percent.From 2014 to 2015, annually measured water levels in the Black Mesa area declined in 9 of 15 wells that were available for comparison in the unconfined areas of the N aquifer, and the median change was -0.1 feet. Water levels declined in 3 of 16 wells measured in the confined area of the aquifer. The median change for the confined area of the aquifer was 0.6 feet. From the prestress period (prior to 1965) to 2015, the median water-level change for 34 wells in both the confined and unconfined areas was -13.2 feet; the median water-level changes were -1.7 feet for 16 wells measured in the unconfined areas and -42.3 feet for 18 wells measured in the confined area.Spring flow was measured at four springs in 2014. Flow fluctuated during the

Induction of synaptic long-term potentiation after opioid withdrawal.

Science.gov (United States)

Drdla, Ruth; Gassner, Matthias; Gingl, Ewald; Sandkühler, Jürgen

2009-07-10

mu-Opioid receptor (MOR) agonists represent the gold standard for the treatment of severe pain but may paradoxically also enhance pain sensitivity, that is, lead to opioid-induced hyperalgesia (OIH). We show that abrupt withdrawal from MOR agonists induces long-term potentiation (LTP) at the first synapse in pain pathways. Induction of opioid withdrawal LTP requires postsynaptic activation of heterotrimeric guanine nucleotide-binding proteins and N-methyl-d-aspartate receptors and a rise of postsynaptic calcium concentrations. In contrast, the acute depression by opioids is induced presynaptically at these synapses. Withdrawal LTP can be prevented by tapered withdrawal and shares pharmacology and signal transduction pathways with OIH. These findings provide a previously unrecognized target to selectively combat pro-nociceptive effects of opioids without compromising opioid analgesia.

Sedative-hypnotic drug withdrawal syndrome: recognition and treatment [digest].

Science.gov (United States)

Santos, Cynthia; Olmedo, Ruben E; Kim, Jeremy

2017-03-22

Sedative-hypnotic drugs include gamma-Aminobutyric acid (GABA)ergic agents such as benzodiazepines, barbiturates, gamma-Hydroxybutyric acid [GHB], gamma-Butyrolactone [GBL], baclofen, and ethanol. Chronic use of these substances can cause tolerance, and abrupt cessation or a reduction in the quantity of the drug can precipitate a life-threatening withdrawal syndrome. Benzodiazepines, phenobarbital, propofol, and other GABA agonists or analogues can effectively control symptoms of withdrawal from GABAergic agents. Managing withdrawal symptoms requires a patient-specific approach that takes into account the physiologic pathways of the particular drugs used as well as the patient's age and comorbidities. Adjunctive therapies include alpha agonists, beta blockers, anticonvulsants, and antipsychotics. Newer pharmacological therapies offer promise in managing withdrawal symptoms. [Points & Pearls is a digest of Emergency Medicine Practice].

Public-supply water use in Kansas, 1990-2012

Science.gov (United States)

Kenny, Joan F.

2014-01-01

This fact sheet describes water-use data collection and quantities of surface water and groundwater diverted for public supply in Kansas for the years 1990 through 2012. Data used in this fact sheet are from the Kansas Department of Agriculture’s Division of Water Resources and the Kansas Water Office. Water used for public supply represents about 10 percent of all reported water withdrawals in Kansas. Between 1990 and 2012, annual withdrawals for public supply ranged from a low of 121 billion gallons in 1993 to a high of 159 billion gallons in 2012. Differences in annual withdrawals were associated primarily with climatic fluctuations. Six suppliers distributed about one-half of the total water withdrawn for public supply, and nearly three-quarters of the surface water. Surface water represented between 52 and 61 percent of total annual withdrawals for public supply. The proportion of surface water obtained through contracts from Federal reservoirs increased from less than 5 percent in the 1990s to 8 percent in 2011 and 2012. More than 99 percent of the reported water withdrawn for public supply in Kansas in 2012 was metered, which was an increase from 92 percent in 1990. State population increased steadily from 2.5 million people in 1990 to 2.9 million in 2012. Recent estimates indicate that about 95 percent of the total population was served by public water supply; the remainder obtained water from other sources such as private wells. Average per capita water use as calculated for State conservation planning purposes varied by region of the State. The smallest regional average water use for the years 1990–2012 was 98 gallons per person per day in easternmost Kansas, and the largest regional average water use was 274 gallons per person per day in westernmost Kansas.

Caffeine Withdrawal and Dependence: A Convenience Survey Among Addiction Professionals.

Science.gov (United States)

Budney, Alan J; Brown, Pamela C; Griffiths, Roland R; Hughes, John R; Juliano, Laura M

2013-06-01

Caffeine withdrawal was included in the research appendix of the DSM-IV to encourage additional research to assist with determining its status for the next version of the manual. Caffeine dependence was not included because of a lack of empirical research at the time of publication. This study assessed the beliefs of addiction professionals about the clinical importance of caffeine withdrawal and dependence. A 6-item survey was developed and delivered electronically to the members of six professional organizations that focus on addiction. Open-ended comments were also solicited. Five hundred members responded. The majority (95%) thought that cessation of caffeine could produce a withdrawal syndrome, and that caffeine withdrawal can have clinical importance (73%); however, only half (48%) thought that caffeine withdrawal should be included in the Diagnostic and Statistical Manual of Mental Disorders (DSM). A majority (58%) believed that some people develop caffeine dependence; however, only 44% indicated that it should be in the DSM. Comments suggested that trepidation about inclusion of caffeine diagnoses was due to the concerns about the field of psychiatry being criticized for including common disorders with a relatively low clinical severity. Others, however, expressed an urgent need to take caffeine-related problems more seriously. The majority of addiction professionals believe that caffeine withdrawal and dependence disorders exist and are clinically important; however, these professionals are divided in whether caffeine withdrawal and dependence should be included in DSM. Wider dissemination of the extant literature on caffeine withdrawal and additional research on caffeine dependence will be needed to provide additional guidance to policymakers and healthcare workers.

[Alcohol withdrawal syndrome dynamics during treatment with nooclerin (deanoli aceglumas)].

Science.gov (United States)

Agibalova, T V; Buzik, O Zh; Rychkova, O V; Smyshlyaev, A V; Rumbesht, V V

2018-01-01

To study the efficacy of nooclerin (deanoli aceglumas) in alcohol withdrawal syndrome assessed by clinical and biochemical characteristics. A multicenter, open, randomized, comparative study of nooclerin in the complex treatment of alcohol withdrawal syndrome included 90 patients. The patients were randomized into nooclerin group (n=55) and control group (n=35). Nooclerin reduced alcohol withdrawal symptoms more significantly throughout the whole study period. There were significant between-group differences on the Clinical Institute Withdrawal Assessment of Alcohol Scale (CIWA-Ar) and the Multidimensional Fatigue Inventory (МFI-20). However, patients exhibited no excessive activity. No adverse side-effects were observed.

Opioid withdrawal syndrome: emerging concepts and novel therapeutic targets.

Science.gov (United States)

Rehni, Ashish K; Jaggi, Amteshwar S; Singh, Nirmal

2013-02-01

Opioid withdrawal syndrome is a debilitating manifestation of opioid dependence and responds poorly to the available clinical therapies. Studies from various in vivo and in vitro animal models of opioid withdrawal syndrome have led to understanding of its pathobiology which includes complex interrelated pathways leading to adenylyl cyclase superactivation based central excitation. Advancements in the elucidation of opioid withdrawal syndrome mechanisms have revealed a number of key targets that have been hypothesized to modulate clinical status. The present review discusses the neurobiology of opioid withdrawal syndrome and its therapeutic target recptors like calcitonin gene related peptide receptors (CGRP), N-methyl-D-aspartate (NMDA) receptors, gamma aminobutyric acid receptors (GABA), G-proteingated inwardly rectifying potassium (GIRK) channels and calcium channels. The present review further details the potential role of second messengers like calcium (Ca2+) / calmodulin-dependent protein kinase (CaMKII), nitric oxide synthase, cytokines, arachidonic acid metabolites, corticotropin releasing factor, fos and src kinases in causing opioid withdrawal syndrome. The exploitation of these targets may provide effective therapeutic agents for the management of opioid dependence-induced abstinence syndrome.

Evaluation of Ashwagandha in alcohol withdrawal syndrome

Directory of Open Access Journals (Sweden)

Ruby B

2012-10-01

Full Text Available Objective: To evaluate the effect of Ashwagandha (ASW in attenuation of alcohol withdrawal in ethanol withdrawal mice model. Methods: Alcohol dependence was induced in mice by the oral, once-daily administration of 10% v/v ethanol (2 g/kg for one week. Once the animals were withdrawn from alcohol, the efficacy of ASW (200mg/kg and 500mg/kg in comparison with diazepam (1 mg/kg in the attenuation of withdrawal was studied using, pentylenetetrazole (PTZ kindling test for seizure threshold, forced swim test (FST for depression and locomotor activity (LCA in open field test (OFT. 6 hours after the last ethanol administration, seizure threshold was measured in all the groups by administering the convulsant drug, PTZ with a subconvulsive dose of 30 mg/kg i.p. In FST, mice were forced to swim and the total duration of immobility (seconds was measured during the last 4 min of a single 6-min test session. In OFT, number of crossings of the lines marked on the floor was recorded for a period of 5 min. Results: Compared to ethanol group, ASW (500 mg/Kg has suppressed the PTZ kindling seizures in ethanol withdrawal animals [0% convulsion], FST has shown decreased immobility time and OFT has exhibited increase in the number of line crossing activity by mice which may be the consequence of anxiolytic activity of ASW similar to that of diazepam. Conclusions: The present study provides satisfactory evidence to use ASW as a safe and reliable alternative to diazepam in alcohol withdrawal conditions.

Water Accounting Plus (WA+) - a water accounting procedure for complex river basins based on satellite measurements

Science.gov (United States)

Karimi, P.; Bastiaanssen, W. G. M.; Molden, D.

2012-11-01

Coping with the issue of water scarcity and growing competition for water among different sectors requires proper water management strategies and decision processes. A pre-requisite is a clear understanding of the basin hydrological processes, manageable and unmanageable water flows, the interaction with land use and opportunities to mitigate the negative effects and increase the benefits of water depletion on society. Currently, water professionals do not have a common framework that links hydrological flows to user groups of water and their benefits. The absence of a standard hydrological and water management summary is causing confusion and wrong decisions. The non-availability of water flow data is one of the underpinning reasons for not having operational water accounting systems for river basins in place. In this paper we introduce Water Accounting Plus (WA+), which is a new framework designed to provide explicit spatial information on water depletion and net withdrawal processes in complex river basins. The influence of land use on the water cycle is described explicitly by defining land use groups with common characteristics. Analogous to financial accounting, WA+ presents four sheets including (i) a resource base sheet, (ii) a consumption sheet, (iii) a productivity sheet, and (iv) a withdrawal sheet. Every sheet encompasses a set of indicators that summarize the overall water resources situation. The impact of external (e.g. climate change) and internal influences (e.g. infrastructure building) can be estimated by studying the changes in these WA+ indicators. Satellite measurements can be used for 3 out of the 4 sheets, but is not a precondition for implementing WA+ framework. Data from hydrological models and water allocation models can also be used as inputs to WA+.

USA Withdrawal from Paris Agreement – What Next?

OpenAIRE

Sergey Chestnoy; Dinara Gershinkova

2017-01-01

In June 2017, President Trump announced the USA’s withdrawal from the Paris Climate Accord, which had been ratified for less than a year, thanks in large part to the USA. That drastic shift followed the change in residency at the White House. Withdrawing from the Paris Accord presents an interesting topic for analysis. There’s the practical side of the withdrawal procedure as set out in Article 28 of the agreement, not to mention the consequences of US non-participation in address...

Methyl Parathion Masks Withdrawal from Physical Dependence on Morphine

Directory of Open Access Journals (Sweden)

Robin W. Rockhold

2002-10-01

Full Text Available Abstract: The cholinergic system has been proposed to participate in the development of dependence on opioids. The present study examined effects of dermal pretreatment with methyl parathion (MP, an acetylcholinesterase inhibitor, on the development of physical dependence on morphine. Opioid dependence was induced by continuous intracerebroventricular (i.c.v. infusion of morphine (26 nmol/μl/h for 3 days in adult male Sprague-Dawley rats. Each rat received two doses of MP, 12.5 mg/kg, dermally, initially, 3 days prior to initiation of i.c.v. morphine infusion and again on the first day of infusion. Withdrawal was precipitated after 3 days of infusion by administering an opioid antagonist, naloxone (48 nmol/5 μl, i.c.v.. Twelve of 23 MP-treated rats exhibited signs of acetylcholinesterase inhibitor intoxication (mild tremors and showed reduced spontaneous locomotor activity (tested by an open field test, prior to naloxone. The brain cholinesterase activity in these 12 rats was 13% of levels in control rats. Eleven rats that did not show toxic signs, exhibited cholinesterase activities that were 20% of control (not significant versus toxic group. The group that showed signs of MP intoxication exhibited a significantly lower incidence of opioid withdrawal jumping, rearing and wet dog shakes compared with the non-toxic group. No differences between quantal withdrawal signs (ptosis, penis-licking, and vocalization were noted between the two groups. The results suggest that toxic inhibition of acetylcholinesterase non-specifically reduces locomotor activity and may obscure certain behavioral signs of withdrawal from opioid dependence. This indicates that caution should be used in interpreting a direct involvement of acetylcholinesterase inhibition in preventing opioid dependence.

Chronic agmatine treatment prevents behavioral manifestations of nicotine withdrawal in mice.

Science.gov (United States)

Kotagale, Nandkishor R; Chopde, Chandrabhan T; Umekar, Milind J; Taksande, Brijesh G

2015-05-05

Smoking cessation exhibits an aversive withdrawal syndrome characterized by both increases in somatic signs and affective behaviors including anxiety and depression. In present study, abrupt withdrawal of daily nicotine injections (2mg/kg, s.c., four times daily, for 10 days) significantly increased somatic signs viz. rearing, grooming, jumping, genital licking, leg licking, head shakes with associated depression (increased immobility in forced swim test) as well as anxiety (decreased the number of entries and time spent in open arm in elevated plus maze) in nicotine dependent animals. The peak effect was observed at 24h time point of nicotine withdrawal. Repeated administration of agmatine (40-80µg/mouse, i.c.v.) before the first daily dose of nicotine from day 5 to 10 attenuated the elevated scores of somatic signs and abolished the depression and anxiety like behavior induced by nicotine withdrawal in dependent animals. However, in separate groups, its acute administration 30min before behavior analysis of nicotine withdrawal was ineffective. This result clearly shows the role of agmatine in development of nicotine dependence and its withdrawal. In extension to behavioral experiments, brain agmatine analyses, carried out at 24h time point of nicotine withdrawal demonstrated marked decrease in basal brain agmatine concentration as compared to control animals. Taken together, these data support the role of agmatine as common biological substrate for somatic signs and affective symptoms of nicotine withdrawal. This data may project therapies based on agmatine in anxiety, depression and mood changes associated with tobacco withdrawal. Copyright © 2015 Elsevier B.V. All rights reserved.

48 CFR 1419.506 - Withdrawing or modifying small business set-asides.

Science.gov (United States)

2010-10-01

... small business set-asides. 1419.506 Section 1419.506 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 1419.506 Withdrawing or modifying small business set-asides. The HCA is authorized, without the power of redelegation...

Using a Content Management System for Integrated Water Quantity, Quality and Instream Flows Modeling

Science.gov (United States)

Burgholzer, R.; Brogan, C. O.; Scott, D.; Keys, T.

2017-12-01

With increased population and water demand, in-stream flows can become depleted by consumptive uses and dilution of permitted discharges may be compromised. Reduced flows downstream of water withdrawals may increase the violation rate of bacterial concentrations from direct deposition by livestock and wildlife. Water storage reservoirs are constructed and operated to insure more stable supplies for consumptive demands and dilution flows, however their use comes at the cost of increased evaporative losses, potential for thermal pollution, interrupted fish migration, and reduced flooding events that are critical to maintain habitat and water quality. Due to this complex interrelationship between water quantity, quality and instream habitat comprehensive multi-disciplinary models must be developed to insure long-term sustainability of water resources and to avoid conflicts between drinking water, food and energy production, and aquatic biota. The Commonwealth of Virginia funded the expansion of the Chesapeake Bay Program Phase 5 model to cover the entire state, and has been using this model to evaluate water supply permit and planning since 2009. This integrated modeling system combines a content management system (Drupal and PHP) for model input data and leverages the modularity of HSPF with the custom segmentation and parameterization routines programmed by modelers working with the Chesapeake Bay Program. The model has been applied to over 30 Virginia Water Permits, instream flows and aquatic habitat models and a Virginias 30 year water supply demand projections. Future versions will leverage the Bay Model auto-calibration routines for adding small-scale water supply and TMDL models, utilize climate change scenarios, and integrate Virginia's reservoir management modules into the Chesapeake Bay watershed model, feeding projected demand and operational changes back up to EPA models to improve the realism of future Bay-wide simulations.

Time-course of the DSM-5 cannabis withdrawal symptoms in poly-substance abusers

DEFF Research Database (Denmark)

Hesse, Morten; Thylstrup, Birgitte

2013-01-01

Background Evidence is accumulating that a cannabis withdrawal syndrome is common, of clinical significance, and has a clear time course. Up till now, very limited data exist on the cannabis withdrawal symptoms in patients with co-morbid substance use disorders, other than cannabis use and tobacco...... the DSM-5 Withdrawal Symptom Check List with withdrawal symptoms from all classes of substances, with no indication that the described symptoms should be attributed to withdrawal. Self-reported time since last use of cannabis was used as a predictor of cannabis withdrawal severity. Results...... With the exception of loss of appetite, time since last use of cannabis was associated with all types of withdrawal symptoms listed in the DSM-5. Only four of 19 symptoms intended to measure withdrawal from other substances were related to time since last use of cannabis, including vivid, unpleasant dreams...

Water systems

International Nuclear Information System (INIS)

Riess, R.

1980-01-01

The present paper describes the coolant chemistry and its consequences for 1300 MWsub(e) KWU PWR plants. Some selected systems, i.e. primary heat transport system, steam water cycle and cooling water arrangements, are chosen for this description. Various aspects of coolant chemistry regarding general corrosion, selective types of corrosion and deposits on heat transfer surfaces have been discussed. The water supply systems necessary to fulfill the requirements of the coolant chemistry are discussed as well. It has been concluded that a good operating performance can only be achieved when - beside other factors - the water chemistry has been given sufficient consideration. (orig./RW)

Water systems

International Nuclear Information System (INIS)

Riess, R.

1981-01-01

The present paper describes the coolant chemistry and its consequences for 1300 MWsub(e) KWU PWR plants. Some selected systems, i.e. primary heat transport system, steam water cycle and cooling water arrangements, are chosen for this description. Various aspects of coolant chemistry regarding general corrosion, selective types of corrosion and deposits on heat transfer surface have been discussed. The water supply systems necessary to fulfill the requirements of the coolant chemistry are discussed as well. It has been concluded that a good operating performance can only be achieved when - beside other factors - the water chemistry has been given sufficient consideration. (orig./RW)

Tolerance and withdrawal from prolonged opioid use in critically ill children.

Science.gov (United States)

Anand, Kanwaljeet J S; Willson, Douglas F; Berger, John; Harrison, Rick; Meert, Kathleen L; Zimmerman, Jerry; Carcillo, Joseph; Newth, Christopher J L; Prodhan, Parthak; Dean, J Michael; Nicholson, Carol

2010-05-01

After prolonged opioid exposure, children develop opioid-induced hyperalgesia, tolerance, and withdrawal. Strategies for prevention and management should be based on the mechanisms of opioid tolerance and withdrawal. Relevant manuscripts published in the English language were searched in Medline by using search terms "opioid," "opiate," "sedation," "analgesia," "child," "infant-newborn," "tolerance," "dependency," "withdrawal," "analgesic," "receptor," and "individual opioid drugs." Clinical and preclinical studies were reviewed for data synthesis. Mechanisms of opioid-induced hyperalgesia and tolerance suggest important drug- and patient-related risk factors that lead to tolerance and withdrawal. Opioid tolerance occurs earlier in the younger age groups, develops commonly during critical illness, and results more frequently from prolonged intravenous infusions of short-acting opioids. Treatment options include slowly tapering opioid doses, switching to longer-acting opioids, or specifically treating the symptoms of opioid withdrawal. Novel therapies may also include blocking the mechanisms of opioid tolerance, which would enhance the safety and effectiveness of opioid analgesia. Opioid tolerance and withdrawal occur frequently in critically ill children. Novel insights into opioid receptor physiology and cellular biochemical changes will inform scientific approaches for the use of opioid analgesia and the prevention of opioid tolerance and withdrawal.

A double blind, within subject comparison of spontaneous opioid withdrawal from buprenorphine versus morphine.

Science.gov (United States)

Tompkins, D Andrew; Smith, Michael T; Mintzer, Miriam Z; Campbell, Claudia M; Strain, Eric C

2014-02-01

Preliminary evidence suggests that there is minimal withdrawal after the cessation of chronically administered buprenorphine and that opioid withdrawal symptoms are delayed compared with those of other opioids. The present study compared the time course and magnitude of buprenorphine withdrawal with a prototypical μ-opioid agonist, morphine. Healthy, out-of-treatment opioid-dependent residential volunteers (N = 7) were stabilized on either buprenorphine (32 mg/day i.m.) or morphine (120 mg/day i.m.) administered in four divided doses for 9 days. They then underwent an 18-day period of spontaneous withdrawal, during which four double-blind i.m. placebo injections were administered daily. Stabilization and spontaneous withdrawal were assessed for the second opioid using the same time course. Opioid withdrawal measures were collected eight times daily. Morphine withdrawal symptoms were significantly (P withdrawal as measured by mean peak ratings of Clinical Opiate Withdrawal Scale (COWS), Subjective Opiate Withdrawal Scale (SOWS), all subscales of the Profile of Mood States (POMS), sick and pain (0-100) Visual Analog Scales, systolic and diastolic blood pressure, heart rate, respiratory rate, and pupil dilation. Peak ratings on COWS and SOWS occurred on day 2 of morphine withdrawal and were significantly greater than on day 2 of buprenorphine withdrawal. Subjective reports of morphine withdrawal resolved on average by day 7. There was minimal evidence of buprenorphine withdrawal on any measure. In conclusion, spontaneous withdrawal from high-dose buprenorphine appears subjectively and objectively milder compared with that of morphine for at least 18 days after drug cessation.

Sustainability of water-supply at military installations, Kabul Basin, Afghanistan

Science.gov (United States)

Mack, Thomas J.; Chornack, Michael P.; Verstraeten, Ingrid M.; Linkov, Igor

2014-01-01

The Kabul Basin, including the city of Kabul, Afghanistan, is host to several military installations of Afghanistan, the United States, and other nations that depend on groundwater resources for water supply. These installations are within or close to the city of Kabul. Groundwater also is the potable supply for the approximately four million residents of Kabul. The sustainability of water resources in the Kabul Basin is a concern to military operations, and Afghan water-resource managers, owing to increased water demands from a growing population and potential mining activities. This study illustrates the use of chemical and isotopic analysis, groundwater flow modeling, and hydrogeologic investigations to assess the sustainability of groundwater resources in the Kabul Basin.Water supplies for military installations in the southern Kabul Basin were found to be subject to sustainability concerns, such as the potential drying of shallow-water supply wells as a result of declining water levels. Model simulations indicate that new withdrawals from deep aquifers may have less of an impact on surrounding community water supply wells than increased withdrawals from near- surface aquifers. Higher rates of recharge in the northern Kabul Basin indicate that military installations in that part of the basin may have fewer issues with long-term water sustainability. Simulations of groundwater withdrawals may be used to evaluate different withdrawal scenarios in an effort to manage water resources in a sustainable manner in the Kabul Basin.

The Study of the Role of Contributor Factors in Addiction Withdrawal

Directory of Open Access Journals (Sweden)

Omar Kianipour

2012-08-01

Full Text Available Introduction: The present paper investigated the factors contributing to addiction withdrawal so as to it would be possible to set preventive and rehabilitative programs for addicts. Method: The study was ex-post facto and causal-comparative one. Population included all addicts referred to addiction withdrawal centers of Kahnouj city and the sample was selected of addicts of Yaran addiction withdrawal Center by voluntary sampling. Bar-on emotional intelligence inventory, family boundary questionnaire and demographic information were administered among selected sample. Results: The results showed that normal family boundaries, higher emotional intelligence and opium use in comparison of crack and crystal glass are effective on addiction withdrawal. But disengaged family boundaries, crack and crystal glass use can be led to addiction recursion. Age, addiction duration, marital status, and education level are not effective on addiction withdrawal. Conclusion: Altogether, the results represented the role and importance of variables namely: family, emotional intelligence, and the kind of used material in addiction withdrawal.

20 CFR 410.232 - Withdrawal of a claim.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Withdrawal of a claim. 410.232 Section 410.232 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969... Claims and Evidence § 410.232 Withdrawal of a claim. (a) Before adjudication of claim. A claimant (or an...

12 CFR 563g.11 - Withdrawal or abandonment.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Withdrawal or abandonment. 563g.11 Section 563g.11 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SECURITIES OFFERINGS § 563g.11 Withdrawal or abandonment. (a) Any offering circular, amendment, or exhibit may be withdrawn...

27 CFR 19.997 - Withdrawal of fuel alcohol.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Withdrawal of fuel alcohol. 19.997 Section 19.997 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... and Transfers § 19.997 Withdrawal of fuel alcohol. For each shipment or other removal of fuel alcohol...

Water Accounting Plus (WA+ – a water accounting procedure for complex river basins based on satellite measurements

Directory of Open Access Journals (Sweden)

P. Karimi

2013-07-01

Full Text Available Coping with water scarcity and growing competition for water among different sectors requires proper water management strategies and decision processes. A pre-requisite is a clear understanding of the basin hydrological processes, manageable and unmanageable water flows, the interaction with land use and opportunities to mitigate the negative effects and increase the benefits of water depletion on society. Currently, water professionals do not have a common framework that links depletion to user groups of water and their benefits. The absence of a standard hydrological and water management summary is causing confusion and wrong decisions. The non-availability of water flow data is one of the underpinning reasons for not having operational water accounting systems for river basins in place. In this paper, we introduce Water Accounting Plus (WA+, which is a new framework designed to provide explicit spatial information on water depletion and net withdrawal processes in complex river basins. The influence of land use and landscape evapotranspiration on the water cycle is described explicitly by defining land use groups with common characteristics. WA+ presents four sheets including (i a resource base sheet, (ii an evapotranspiration sheet, (iii a productivity sheet, and (iv a withdrawal sheet. Every sheet encompasses a set of indicators that summarise the overall water resources situation. The impact of external (e.g., climate change and internal influences (e.g., infrastructure building can be estimated by studying the changes in these WA+ indicators. Satellite measurements can be used to acquire a vast amount of required data but is not a precondition for implementing WA+ framework. Data from hydrological models and water allocation models can also be used as inputs to WA+.

Effects of Aquifer Development and Changes in Irrigation Practices on Ground-Water Availability in the Santa Isabel Area, Puerto Rico

Science.gov (United States)

Kuniansky, Eve L.; Gómez-Gómez, Fernando; Torres-Gonzalez, Sigfredo

2003-01-01

The alluvial aquifer in the area of Santa Isabel is located within the South Coastal Plain aquifer of Puerto Rico. Variations in precipitation, changes in irrigation practices, and increasing public-supply water demand have been the primary factors controlling water-level fluctuations within the aquifer. Until the late 1970s, much of the land in the study area was irrigated using inefficient furrow flooding methods that required large volumes of both surface and ground water. A gradual shift in irrigation practices from furrow systems to more efficient micro-drip irrigation systems occurred between the late 1970s and the late 1980s. Irrigation return flow from the furrow-irrigation systems was a major component of recharge to the aquifer. By the early 1990s, furrow-type systems had been replaced by the micro-drip irrigation systems. Water levels declined about 20 feet in the aquifer from 1985 until present (February 2003). The main effect of the changes in agricultural practices is the reduction in recharge to the aquifer and total irrigation withdrawals. Increases in ground-water withdrawals for public supply offset the reduction in ground-water withdrawals for irrigation such that the total estimated pumping rate in 2003 was only 8 percent less than in 1987. Micro-drip irrigation resulted in the loss of irrigation return flow to the aquifer. These changes resulted in lowering the water table below sea level over most of the Santa Isabel area. By 2002, lowering of the water table reversed the natural discharge along the coast and resulted in the inland movement of seawater, which may result in increased salinity of the aquifer, as had occurred in other parts of the South Coastal Plain. Management alternatives for the South Coastal Plain aquifer in the vicinity of Santa Isabel include limiting groundwater withdrawals or implementing artificial recharge measures. Another alternative for the prevention of saltwater intrusion is to inject freshwater or treated sewage

Psychosocial withdrawal characteristics of nicotine compared with alcohol and caffeine.

Science.gov (United States)

Miyata, Hisatsugu; Hironaka, Naoyuki; Takada, Kohji; Miyasato, Katsumasa; Nakamura, Koichi; Yanagita, Tomoji

2008-10-01

The purpose of the present study was to observe the psychosocial characteristics of withdrawal from cigarette smoking in comparison with those from caffeine (CAF) and alcoholic (ALC) beverage withdrawal. Twenty-seven healthy volunteers at a medial level of dependence on both cigarettes (nicotine, NCT) and either CAF or ALC, as judged by the DSM-IV-TR criteria for substance dependence, participated in this study. The participants were required to abstain from smoking and either CAF or ALC for 7 days, each one after another, with a 7-day interval. The order of abstinence was counterbalanced among the participants. Psychosocial parameters, including a desire for substances, social activity function, well-being, withdrawal symptoms, and vital signs, were assessed during the withdrawal periods. The study protocol was approved by the Jikei University Review Board. The results indicated that there were no differences in the maximum level of desire for a substance and the influence on social activity function between NCT and other substances during the withdrawal periods. As for withdrawal symptoms, NCT caused a more intensive degree of irritability than CAF or ALC, and a more intensive degree of difficulty concentrating and restlessness than did withdrawal from ALC. However, the subjective well-being questionnaire indicated no differences in these symptoms between NCT and other substances. The present results suggest that there are no significant differences in psychosocial manifestations regarding the difficulty in abstaining from NCT, CAF, and ALC.

Safety analysis of a high temperature supercritical pressure light water cooled and moderated reactor

International Nuclear Information System (INIS)

Ishiwatari, Y.; Oka, Y.; Koshizuka, S.

2002-01-01

A safety analysis code for a high temperature supercritical pressure light water cooled reactor (SCLWR-H) with water rods cooled by descending flow, SPRAT-DOWN, is developed. The hottest channel, a water rod, down comer, upper and lower plenums, feed pumps, etc. are modeled as junction of nodes. Partial of the feed water flows downward from the upper dome of the reactor pressure vessel to the water rods. The accidents analyzed here are total loss of feed water flow, feed water pump seizure, and control rods ejection. All the accidents satisfy the criteria. The accident event at which the maximum cladding temperature is the highest is total loss of feedwater flow. The transients analyzed here are loss of feed water heating, inadvertent start-up of an auxiliary water supply system, partial loss of feed water flow, loss of offsite power, loss of load, and abnormal withdrawal of control rods. All the transients satisfied the criteria. The transient event for which the maximum cladding temperature is the highest is control rod withdrawal at normal operation. The behavior of loss of load transient is different from that of BWR. The power does not increase because loss of flow occurs and the density change is small. The sensitivities of the system behavior to various parameters during transients and accidents are analyzed. The parameters having strong influence are the capacity of the auxiliary water supply system, the coast down time of the main feed water pumps, and the time delay of the main feed water pumps trip. The control rod reactivity also has strong influence. (authors)

The Treatment of Clozapine-Withdrawal Delirium with Electroconvulsive Therapy

Directory of Open Access Journals (Sweden)

Anish Modak

2017-01-01

Full Text Available Clozapine, a commonly used atypical antipsychotic, can precipitate a severe withdrawal syndrome. In this report, we describe a case of delirium with catatonic features emerging after the immediate cessation of clozapine subsequent to concerns of developing neuroleptic malignant syndrome. After multiple treatments were found to be inefficacious, electroconvulsive therapy (ECT was initiated, resulting in significant improvement. A literature search revealed six previous cases of clozapine-withdrawal syndromes of varied symptomatology treated with ECT. To our knowledge, the present case represents the first reported clozapine-withdrawal delirium treated successfully with ECT.

Youth social withdrawal behavior (hikikomori): A systematic review of qualitative and quantitative studies.

Science.gov (United States)

Li, Tim M H; Wong, Paul W C

2015-07-01

Acute and/or severe social withdrawal behavior among youth was seen as a culture-bound psychiatric syndrome in Japan, but more youth social withdrawal cases in different countries have been discovered recently. However, due to the lack of a formal definition and diagnostic tool for youth social withdrawal, cross-cultural observational and intervention studies are limited. We aimed to consolidate existing knowledge in order to understand youth social withdrawal from diverse perspectives and suggest different interventions for different trajectories of youth social withdrawal. This review examined the current available scientific information on youth social withdrawal in the academic databases: ProQuest, ScienceDirect, Web of Science and PubMed. We included quantitative and qualitative studies of socially withdrawn youths published in English and academic peer-reviewed journals. We synthesized the information into the following categories: (1) definitions of youth social withdrawal, (2) developmental theories, (3) factors associated with youth social withdrawal and (4) interventions for socially withdrawn youths. Accordingly, there are diverse and controversial definitions for youth social withdrawal. Studies of youth social withdrawal are based on models that lead to quite different conclusions. Researchers with an attachment perspective view youth social withdrawal as a negative phenomenon, whereas those who adopt Erikson's developmental theory view it more positively as a process of seeking self-knowledge. Different interventions for socially withdrawn youths have been developed, mainly in Japan, but evidence-based practice is almost non-existent. We propose a theoretical framework that views youth social withdrawal as resulting from the interplay between psychological, social and behavioral factors. Future validation of the framework will help drive forward advances in theory and interventions for youth social withdrawal as an emerging issue in developed

Smartphone Restriction and its Effect on Subjective Withdrawal Related Scores

OpenAIRE

Aarestad, Sarah Helene; Eide, Tine Almenning

2017-01-01

Smartphone overuse is associated with a number of negative consequences for the individual and the environment. In the right end of the distribution of smartphone usage, concepts such as smartphone addiction seem warranted. An area that so far lacks research concerns the effect of smartphone restriction generally and specifically on subjective withdrawal related scores across different degrees of smartphone usage. The present study examined withdrawal related scores on the Smartphone Withdraw...

An analytic-geospatial approach for sustainable water resource management: a case study in the province of Perugia

Directory of Open Access Journals (Sweden)

Stefano Casadei

2013-09-01

Full Text Available Water is a strategic, but also highly vulnerable, natural resource. This because the increasing demand from multiple uses, in many cases competing amongst them, seems to influence the concepts of sustainability of the exploitation. From the operational point of view, the studied system is an integrated decision support system. It is not only a platform to exchange information and assessments, but also a tool for conflict resolution, in the management of water resources, to obtain the consensus among all participants in the decisional processes. So the canonical “top-down” approach has been replaced with a “bottom-up” approach where all stakeholders become decision makers themselves. The application of the aforementioned approach was studied for the Tiber River basin and has been applied to the Province of Perugia area. The study focused to the building of a spatial database of hydrological data and multipurpose water withdrawals, together with the setting of the evaluation model for the surface water resources. This model bases its algorithms on regionalization procedures of flow parameters. For the definition of the river condition, hydrological indices calculated from the hydrological database have been used, while for the existing withdrawals, an analysis procedure has been developed, that from the point of interest directly selected on the map, finds out the upstream basin and, by means of overlay procedures, identifies the upstream water uses and the total flow that could be extracted. The potential of the system and the technologies used are contained in a WEB platform that allows the analysis of the database of water uses/withdrawals on the cartography, and the comparison with the hydrogeological characteristics of the sub-basin examined. The purpose of this study is to provide software tools that can be used as a support in water resource evaluation and management policies at the basin scale.

Water: A critical resource in the thermoelectric power industry

International Nuclear Information System (INIS)

Feeley, Thomas J. III.; McNemar, Andrea; Skone, Timothy J.; Stiegel, Gary J. Jr.; Nemeth, Michael; Schimmoller, Brian; Murphy, James T.; Manfredo, Lynn

2008-01-01

Water availability represents a growing concern for meeting future power generation needs. In the United States, projected population growth rates, energy consumption patterns, and demand from competing water use sectors will increase pressure on power generators to reduce water use. Water availability and use also exhibit strong regional variations, complicating the nature of public policy and technological response. The US Department of Energy's (DOE) National Energy Technology Laboratory (NETL) is engaged in a research and development (R and D) program to reduce freshwater withdrawal (total quantity of water utilized) and consumption (portion of withdrawal not returned to the source) from existing and future thermoelectric power generating facilities. The Innovations for Existing Plants (IEP) Program is currently developing technologies in 5 categories of water management projects to reduce water use while minimizing the impacts of plant operations on water quality. This paper outlines the freshwater withdrawal and consumption rates for various thermoelectric power generating types and then estimates the potential benefits of IEP program technologies at both the national and regional levels in the year 2030. NETL is working to protect and conserve water resources while leveraging domestic fossil fuel resources, such as coal, to increase national energy security. (author)

The acute tobacco withdrawal syndrome among black smokers.

Science.gov (United States)

Robinson, Cendrine D; Pickworth, Wallace B; Heishman, Stephen J; Waters, Andrew J

2014-03-01

Black smokers have greater difficulty quitting tobacco than White smokers, but the mechanisms underlying between-race differences in smoking cessation are not clear. One possibility is that Black smokers experience greater acute withdrawal than Whites. We investigated whether Black (n = 104) and White smokers (n = 99) differed in abstinence-induced changes in self-report, physiological, and cognitive performance measures. Smokers not wishing to quit completed two counterbalanced experimental sessions. Before one session, they abstained from smoking for at least 12 hr. They smoked normally before the other session. Black smokers reported smaller abstinence-induced changes on a number of subjective measures including the total score of the 10-item Questionnaire for Smoking Urges (QSU) and the total score of the Wisconsin Smoking Withdrawal Scale (WSWS). However, on most subjective measures, and on all objective measures, there were no between-race differences in abstinence-induced change scores. Moreover, Black participants did not report lower QSU and WSWS ratings at the abstinent session, but they did experience significantly higher QSU and WSWS ratings at the nonabstinent session. Abstinence-induced changes in subjective, physiological, and cognitive measures in White smokers were similar for smokers of nonflavored and menthol-flavored cigarettes. There was no evidence that Black smokers experienced greater acute tobacco withdrawal than Whites. To the contrary, Black participants experienced smaller abstinence-induced changes in self-reported craving and withdrawal on some measures. Racial differences in smoking cessation are unlikely to be explained by acute withdrawal.

5 CFR 831.1207 - Withdrawal of disability retirement applications.

Science.gov (United States)

2010-01-01

... type. (d) OPM also considers a disability retirement application to be withdrawn when the agency... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Withdrawal of disability retirement...) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Disability Retirement § 831.1207 Withdrawal of...

Opioid withdrawal signs and symptoms in children: frequency and determinants.

Science.gov (United States)

Fisher, Deborah; Grap, Mary Jo; Younger, Janet B; Ameringer, Suzanne; Elswick, R K

2013-01-01

The purpose of this study was to, in a pediatric population, describe the frequency of opioid withdrawal signs and symptoms and to identify factors associated with these opioid withdrawal signs and symptoms. Opioids are used routinely in the pediatric intensive care population for analgesia, sedation, blunting of physiologic responses to stress, and safety. In children, physical dependence may occur in as little as 2-3 days of continuous opioid therapy. Once the child no longer needs the opioid, the medications are reduced over time. A prospective, descriptive study was conducted. The sample of 26 was drawn from all patients, ages 2 weeks to 21 years admitted to the Children's Hospital of Richmond pediatric intensive care unit (PICU) and who have received continuous infusion or scheduled opioids for at least 5 days. Data collected included: opioid withdrawal score (WAT-1), opioid taper rate (total dose of opioid per day in morphine equivalents per kilogram [MEK]), pretaper peak MEK, pretaper cumulative MEK, number of days of opioid exposure prior to taper, and age. Out of 26 enrolled participants, only 9 (45%) had opioid withdrawal on any given day. In addition, there was limited variability in WAT-1 scores. The most common symptoms notes were diarrhea, vomit, sweat, and fever. For optimal opioid withdrawal assessments, clinicians should use a validated instrument such as the WAT-1 to measure for signs and symptoms of opioid withdrawal. Further research is indicated to examine risk factors for opioid withdrawal in children. Copyright © 2013 Elsevier Inc. All rights reserved.

U.S. withdrawal from the Paris Agreement: Reasons, impacts, and China's response

OpenAIRE

Hai-Bin Zhang; Han-Cheng Dai; Hua-Xia Lai; Wen-Tao Wang

2017-01-01

Applying qualitative and quantitative methods, this article explains the driving forces behind U.S. President Donald Trump's decision to withdraw from the Paris Agreement, assesses the impacts of this withdrawal on the compliance prospects of the agreement, and proposes how China should respond. The withdrawal undercuts the foundation of global climate governance and upsets the process of climate cooperation, and the impacts are manifold. The withdrawal undermines the universality of the Pari...

Pharmacological Treatment of Neonatal Opiate Withdrawal: Between the Devil and the Deep Blue Sea

Directory of Open Access Journals (Sweden)

Anthony Liu

2011-01-01

Full Text Available Illicit drug use with opiates in pregnancy is a major global health issue with neonatal withdrawal being a common complication. Morphine is the main pharmacological agent administered for the treatment of neonatal withdrawal. In the past, morphine has been considered by and large inert in terms of its long-term effects on the central nervous system. However, recent animal and clinical studies have demonstrated that opiates exhibit significant effects on the growing brain. This includes direct dose-dependent effects on reduction in brain size and weight, protein, DNA, RNA, and neurotransmitters—possibly as a direct consequence of a number of opiate-mediated systems that influence neural cell differentiation, proliferation, and apoptosis. At this stage, we are stuck between the devil and the deep blue sea. There are no real alternatives to pharmacological treatment with opiates and other drugs for neonatal opiate withdrawal and opiate addiction in pregnant women. However, pending further rigorous studies examining the potential harmful effects of opiate exposure in utero and the perinatal period, prolonged use of these agents in the neonatal period should be used judiciously, with caution, and avoided where possible.

Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment

DEFF Research Database (Denmark)

Askgaard, Gro; Hallas, Jesper; Fink-Jensen, Anders

2016-01-01

BACKGROUND: Long-acting benzodiazepines such as chlordiazepoxide are recommended as first-line treatment for alcohol withdrawal. These drugs are known for their abuse liability and might increase alcohol consumption among problem drinkers. Phenobarbital could be an alternative treatment option......, possibly with the drawback of a more pronounced acute toxicity. We evaluated if phenobarbital compared to chlordiazepoxide decreased the risk of subsequent use of benzodiazepines, alcohol recidivism and mortality. METHODS: The study was a register-based cohort study of patients admitted for alcohol...... withdrawal 1998-2013 and treated with either phenobarbital or chlordiazepoxide. Patients were followed for one year. We calculated hazard ratios (HR) for benzodiazepine use, alcohol recidivism and mortality associated with alcohol withdrawal treatment, while adjusting for confounders. RESULTS: A total...

An integrated crop and hydrologic modeling system to estimate hydrologic impacts of crop irrigation demands

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R.T. McNider; C. Handyside; K. Doty; W.L. Ellenburg; J.F. Cruise; J.R. Christy; D. Moss; V. Sharda; G. Hoogenboom; Peter Caldwell

2015-01-01

The present paper discusses a coupled gridded crop modeling and hydrologic modeling system that can examine the benefits of irrigation and costs of irrigation and the coincident impact of the irrigation water withdrawals on surface water hydrology. The system is applied to the Southeastern U.S. The system tools to be discussed include a gridded version (GriDSSAT) of...

Mice from lines selectively bred for high voluntary wheel running exhibit lower blood pressure during withdrawal from wheel access.

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Kolb, Erik M; Kelly, Scott A; Garland, Theodore

2013-03-15

Exercise is known to be rewarding and have positive effects on mental and physical health. Excessive exercise, however, can be the result of an underlying behavioral/physiological addiction. Both humans who exercise regularly and rodent models of exercise addiction sometimes display behavioral withdrawal symptoms, including depression and anxiety, when exercise is denied. However, few studies have examined the physiological state that occurs during this withdrawal period. Alterations in blood pressure (BP) are common physiological indicators of withdrawal in a variety of addictions. In this study, we examined exercise withdrawal in four replicate lines of mice selectively bred for high voluntary wheel running (HR lines). Mice from the HR lines run almost 3-fold greater distances on wheels than those from non-selected control lines, and have altered brain activity as well as increased behavioral despair when wheel access is removed. We tested the hypothesis that male HR mice have an altered cardiovascular response (heart rate, systolic, diastolic, and mean arterial pressure [MAP]) during exercise withdrawal. Measurements using an occlusion tail-cuff system were taken during 8 days of baseline, 6 days of wheel access, and 2 days of withdrawal (wheel access blocked). During withdrawal, HR mice had significantly lower systolic BP, diastolic BP, and MAP than controls, potentially indicating a differential dependence on voluntary wheel running in HR mice. This is the first characterization of a cardiovascular withdrawal response in an animal model of high voluntary exercise. Copyright © 2013. Published by Elsevier Inc.

75 FR 12804 - Withdrawal of Regulatory Guide 8.6

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2010-03-17

... ``Regulatory Guides'' in the NRC's Electronic Reading Room at http://www.nrc.gov/reading-rm/doc-collections... NUCLEAR REGULATORY COMMISSION [NRC-2010-0103] Withdrawal of Regulatory Guide 8.6 AGENCY: Nuclear Regulatory Commission. ACTION: Withdrawal of Regulatory Guide 8.6, ``Standard Test Procedure for Geiger-M...

40 CFR 180.8 - Withdrawal of petitions without prejudice.

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2010-07-01

... prejudice. 180.8 Section 180.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 180.8 Withdrawal of petitions without prejudice. In some cases the Administrator will notify the... clarification or the obtaining of additional data. This withdrawal may be without prejudice to a future filing...

Caffeine withdrawal symptoms and self-administration following caffeine deprivation.

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Mitchell, S H; de Wit, H; Zacny, J P

1995-08-01

This study examined the effects of complete or partial caffeine deprivation on withdrawal symptomatology and self-administration of coffee in caffeine-dependent coffee drinkers. Nine habitual coffee drinkers abstained from dietary sources of caffeine for 33.5 h. Caffeine deprivation was manipulated by administering capsules containing 0%, 50%, or 100% of each subject's daily caffeine intake (complete, partial, and no deprivation conditions). Caffeine withdrawal symptomatology was measured using self-report questionnaires. Caffeine self-administration was measured using: i) the amount of coffee subjects earned on a series of concurrent random-ratio schedules that yielded coffee and money reinforcers; ii) the amount of earned coffee they consumed. Saliva samples revealed that subjects complied with the caffeine abstinence instructions. Caffeine withdrawal symptoms occurred reliably following complete caffeine deprivation, though not in the partial deprivation condition. Caffeine self-administration was not related to deprivation condition. We conclude that caffeine withdrawal symptomatology is not necessarily associated with increased caffeine consumption.

Steroid withdrawal in renal transplant patients: the Irish experience.

LENUS (Irish Health Repository)

Phelan, P J

2012-02-01

BACKGROUND: Steroid therapy is associated with significant morbidity in renal transplant recipients. However, there is concern that steroid withdrawal will adversely affect outcome. METHODS: We report on 241 renal transplant recipients on different doses of corticosteroids at 3 months (zero, <\\/= 5 mg\\/day, > 5 mg\\/day). Parameters analysed included blood pressure, lipid profile, weight change, new onset diabetes after transplantation (NODAT), allograft survival and acute rejection. RESULTS: Elimination of corticosteroids had no impact on allograft survival at 1 year. There were no cases of NODAT in the steroid withdrawal group compared with over 7% in each of the steroid groups. There were no significant improvements in weight gain, blood pressure control or total cholesterol with withdrawal of steroids before 3 months. CONCLUSIONS: In renal transplant patients treated with tacrolimus and mycophenolate, early withdrawal of steroids does not appear to adversely affect allograft outcome at 1 year. It may result in less NODAT.

Steroid withdrawal in renal transplant patients: the Irish experience.

LENUS (Irish Health Repository)

Phelan, P J

2010-10-29

BACKGROUND: Steroid therapy is associated with significant morbidity in renal transplant recipients. However, there is concern that steroid withdrawal will adversely affect outcome. METHODS: We report on 241 renal transplant recipients on different doses of corticosteroids at 3 months (zero, ≤5 mg\\/day, >5 mg\\/day). Parameters analysed included blood pressure, lipid profile, weight change, new onset diabetes after transplantation (NODAT), allograft survival and acute rejection. RESULTS: Elimination of corticosteroids had no impact on allograft survival at 1 year. There were no cases of NODAT in the steroid withdrawal group compared with over 7% in each of the steroid groups. There were no significant improvements in weight gain, blood pressure control or total cholesterol with withdrawal of steroids before 3 months. CONCLUSIONS: In renal transplant patients treated with tacrolimus and mycophenolate, early withdrawal of steroids does not appear to adversely affect allograft outcome at 1 year. It may result in less NODAT.

Determination of Screw and Nail Withdrawal Resistance of Some Important Wood Species

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Alper Aytekin

2008-04-01

Full Text Available In this study, screw and nail withdrawal resistance of fir (Abies nordmanniana, oak (Quercus robur L. black pine (Pinus nigra Arnold and Stone pine (Pinus pinea L. wood were determined and compared. The data represent the testing of withdrawal resistance of three types of screws as smart, serrated and conventional and common nails. The specimens were prepared according to TS 6094 standards. The dimensions of the specimens were 5x5x15cm and for all of the directions. Moreover, the specimens were conditioned at ambient room temperature and 65±2% relative humidity. The screws and nails were installed according to ASTM-D 1761 standards. Nail dimensions were 2.5mm diameter and 50 mm length, conventional screws were 4x50mm, serrated screws were 4x45mm and smart screws were 4x50mm. Results show that the maximum screw withdrawal resistance value was found in Stone pine for the serrated screw. There were no significant differences between Stone pine and oak regarding screw withdrawal resistance values. Conventional screw yielded the maximum screw withdrawal resistance value in oak, followed by Stone pine, black pine and fir. Oak wood showed the maximum screw withdrawal resistance value for the smart screw, followed by Stone pine, black pine, and fir. Oak wood showed higher nail withdrawal resistances than softwood species. It was also determined that oak shows the maximum nail withdrawal resistance in all types. The nail withdrawal resistances at the longitudinal direction are lower with respect to radial and tangential directions.

A genetic perspective on the proposed inclusion of cannabis withdrawal in the DSM-5

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Verweij, K.J.H.; Agrawal, A.; Nat, N.O.; Creemers, H.E.; Huizink, A.C.; Martin, N.G.; Lynskey, M.T.

2013-01-01

Background Various studies support the inclusion of cannabis withdrawal to the diagnosis of cannabis use disorders in the upcoming DSM-5. The aims of the current study were to (1) estimate the prevalence of DSM-5 cannabis withdrawal (Criterion B), (2) estimate the role of genetic and environmental influences on individual differences in cannabis withdrawal, and (3) determine the extent to which genetic and environmental influences on cannabis withdrawal overlap with those on DSM-IV defined abuse/dependence. Methods The sample included 2276 lifetime cannabis-using adult Australian twins. Cannabis withdrawal was defined in accordance with Criterion B of the proposed DSM-5 revisions. Cannabis abuse/dependence was defined as endorsing one or more DSM-IV criteria of abuse or three or more dependence criteria. The classical twin model was used to estimate the genetic and environmental influences on variation in cannabis withdrawal, as well as its covariation with abuse/dependence. Results Of all cannabis users 11.9% met criteria for cannabis withdrawal. Around 50% of between-individual variation in withdrawal could be attributed to additive genetic variation, and the rest of the variation was mostly due to non-shared environmental influences. Importantly, the genetic influences on cannabis withdrawal almost completely (99%) overlapped with those on abuse/dependence. Conclusions We showed that cannabis withdrawal symptoms exist among cannabis users, and that cannabis withdrawal is moderately heritable. Genetic influences on cannabis withdrawal are the same as those influencing abuse/dependence. These results add to the wealth of literature that recommends the addition of cannabis withdrawal to the diagnosis of DSM-5 cannabis use disorders. PMID:23194657

Water within the Shared Socioeconomic Pathways: Constraints and the Impact on Future Global Change Scenarios

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Graham, N. T.; Hejazi, M. I.; Davies, E. G.; Calvin, K. V.; Kim, S. H.; Miralles-Wilhelm, F.

2017-12-01

The Shared Socioeconomic Pathways (SSPs) represent the next generation of future global change scenarios and their inclusion in the Coupled Model Intercomparison Project Phase 6 (CMIP6) scenarios reinforces the importance of a complete understanding of the SSPs. This study uses the Global Change Assessment Model (GCAM) to investigate the effects of limited water supplies on future withdrawals at regional and water basin scales across all SSPs in combination with various climate mitigation scenarios. Water supply is calculated using a global hydrologic model and water data from five ISI-MIP models across the four RCP scenarios. When water constraints are incorporated, our results show that water withdrawals are reduced by as much as 40% across all SSP scenarios without climate policies. As climate policies are imposed and become more stringent, water withdrawals increase in regions already affected by water stress in order to allow for greater biomass production. The results of this research show the importance of including water resource constraints within the SSP scenarios for establishing water withdrawal scenarios under a wide range of scenarios including different climate policies. The results will also provide data products - such as gridded land use and water demand estimates - of potential interest to the impact, adaptation, and vulnerability community following the SSP scenarios.

Acupuncture Attenuates Anxiety-Like Behavior by Normalizing Amygdaloid Catecholamines during Ethanol Withdrawal in Rats

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Zheng Lin Zhao

2011-01-01

Full Text Available Previously, we demonstrated acupuncture at acupoint HT7 (Shen-Men attenuated ethanol withdrawal syndrome by normalizing the dopamine release in nucleus accumbens shell. In the present study, we investigated the effect of acupuncture on anxiety-like behavior in rats and its relevant mechanism by studying neuro-endocrine parameters during ethanol withdrawal. Rats were treated with 3 g kg−1day−1 of ethanol (20%, w/v or saline by intraperitoneal injections for 28 days. The rats undergoing ethanol withdrawal exhibited anxiety-like behavior 72 h after the last dose of ethanol characterized by the decrease of time spent in the open arms of the elevated plus maze compared with the saline-treated rats (P < .05. Radioimmunoassay exhibited there were notably increased concentrations of plasma corticosterone in ethanol-withdrawn rats compared with saline-treated rats (P < .05. Additionally, high performance liquid chromatography analysis also showed the levels of norepinephrine and 3-methoxy-4-hydroxy-phenylglycol were markedly increased while the levels of dopamine and 3,4-dihydroxyphenylacetic acid were significantly decreased in the central nucleus of the amygdala of ethanol-withdrawn rats compared with saline-treated rats (P < .01. Acupuncture groups were treated with acupuncture at acupoint HT7 or PC6 (Nei-Guan. Acupuncture at HT7 but not PC6 greatly attenuated the anxiety-like behavior during ethanol withdrawal as evidenced by significant increases in the percentage of time spent in open arms (P < .05. In the meantime, acupuncture at HT7 also markedly inhibited the alterations of neuro-endocrine parameters induced by ethanol withdrawal (P < .05. These results suggest that acupuncture may attenuate anxiety-like behavior during ethanol withdrawal through regulation of neuro-endocrine system.

Evidence for a causative role of N-methyl-D-aspartate receptors in an in vitro model of alcohol withdrawal hyperexcitability.

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Thomas, M P; Monaghan, D T; Morrisett, R A

1998-10-01

Synaptic mechanisms underlying hyperexcitability due to withdrawal from chronic ethanol exposure were investigated in a hippocampal explant model system using electrophysiological techniques. Whole-cell voltage clamp recordings from CA1 pyramidal cells demonstrated that acute ethanol exposure inhibited N-methyl-D-aspartate receptor (NMDAR)-mediated excitatory postsynaptic currents by over 40%. Chronic ethanol exposure for 6 to 11 days at 35 or 75 mM induced no differences from control explants in the fast component of the population synaptic response (non-NMDAR-mediated). Prolonged field potential recordings (to 10 hr) were used to monitor the withdrawal process in vitro. Ethanol-exposed explants from both 35 and 75 mM groups displayed an increase (60% and 89%, respectively) in the NMDAR-mediated component of synaptic transmission on withdrawal from chronic exposure. Prolonged tonic-clonic electrographic seizure activity was consistently observed after ethanol withdrawal only after the increase in NMDAR function. This hyperexcitability was inhibited by the NMDAR antagonist D-2-amino-5-phosphonovaleric acid and returned once the NMDAR component was reestablished after antagonist washout. In situ hybridization studies suggest that expression of NR2B subunit mRNA may be enhanced in explants after chronic ethanol exposure. No lasting differences were observed in the NMDAR component after acute in vitro ethanol exposure and withdrawal. These data suggest that the occurance of ethanol withdrawal hyperexcitability in this system may be directly dependent on alterations in NMDAR function after chronic exposure. Since this region and others that contain ethanol sensitive NMDARs may serve as epileptic foci, long term alterations in NMDAR function may be expected to generate paroxysmal depolarizing shifts underlying ictal events after withdrawal from ethanol exposure.

Caffeine, sleep and wakefulness: implications of new understanding about withdrawal reversal.

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James, Jack E; Keane, Michael A

2007-12-01

The broad aim of this review is to critically examine the implications of new understanding concerning caffeine withdrawal and withdrawal reversal in the context of research concerned with the effects of caffeine on sleep and wakefulness. A comprehensive search was conducted for relevant experimental studies in the PubMED and PsycINFO databases. Studies were assessed with particular reference to methodological adequacy for controlling against confounding due to caffeine withdrawal and withdrawal reversal. This assessment was used to clarify evidence of effects, highlight areas of ambiguity and derive recommendations for future research. It was found that researchers have generally failed to take account of the fact that habitual use of caffeine, even at moderate levels, leads to physical dependence evidenced by physiological, behavioural and subjective withdrawal effects during periods of abstinence. Consequently, there has been near-complete absence of adequate methodological controls against confounding due to reversal of withdrawal effects when caffeine is experimentally administered. The findings of what has been a substantial research effort to elucidate the effects of caffeine on sleep and wakefulness, undertaken over a period spanning decades, are ambiguous. Current shortcomings can be redressed by incorporating suitable controls in new experimental designs.

Simulation of groundwater conditions and streamflow depletion to evaluate water availability in a Freeport, Maine, watershed

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Nielsen, Martha G.; Locke, Daniel B.

2012-01-01

In order to evaluate water availability in the State of Maine, the U.S. Geological Survey (USGS) and the Maine Geological Survey began a cooperative investigation to provide the first rigorous evaluation of watersheds deemed "at risk" because of the combination of instream flow requirements and proportionally large water withdrawals. The study area for this investigation includes the Harvey and Merrill Brook watersheds and the Freeport aquifer in the towns of Freeport, Pownal, and Yarmouth, Maine. A numerical groundwater- flow model was used to evaluate groundwater withdrawals, groundwater-surface-water interactions, and the effect of water-management practices on streamflow. The water budget illustrates the effect that groundwater withdrawals have on streamflow and the movement of water within the system. Streamflow measurements were made following standard USGS techniques, from May through September 2009 at one site in the Merrill Brook watershed and four sites in the Harvey Brook watershed. A record-extension technique was applied to estimate long-term monthly streamflows at each of the five sites. The conceptual model of the groundwater system consists of a deep, confined aquifer (the Freeport aquifer) in a buried valley that trends through the middle of the study area, covered by a discontinuous confining unit, and topped by a thin upper saturated zone that is a mixture of sandy units, till, and weathered clay. Harvey and Merrill Brooks flow southward through the study area, and receive groundwater discharge from the upper saturated zone and from the deep aquifer through previously unknown discontinuities in the confining unit. The Freeport aquifer gets most of its recharge from local seepage around the edges of the confining unit, the remainder is received as inflow from the north within the buried valley. Groundwater withdrawals from the Freeport aquifer in the study area were obtained from the local water utility and estimated for other categories. Overall

Children's judgements of social withdrawal behaviours.

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Watling, Dawn

2015-06-01

Ding et al. (Brit. J. Dev. Psychol., 2015; 33, 159-173) demonstrated that Chinese children discriminate between the three subtypes of social withdrawal: Shyness, unsociability, and social avoidance. This commentary on the Ding et al.'s paper highlights the need to further explore the following: (1) children's understanding of the implications of being shy, unsociable, or socially avoidant, including assessing these which we know are associated with outcomes for socially withdrawn children; (2) what additional subtypes might exist naturally within the Chinese culture; and (3) consider the implications of social withdrawal on children's developing social skills. © 2015 The British Psychological Society.

Water for electricity in India: A multi-model study of future challenges and linkages to climate change mitigation

Energy Technology Data Exchange (ETDEWEB)

Srinivasan, Shweta; Kholod, Nazar; Chaturvedi, Vaibhav; Ghosh, Probal Pratap; Mathur, Ritu; Clarke, Leon; Evans, Meredydd; Hejazi, Mohamad; Kanudia, Amit; Koti, Poonam Nagar; Liu, Bo; Parikh, Kirit S.; Ali, Mohammed Sahil; Sharma, Kabir

2018-01-01

This paper provides projections of water withdrawals and consumption for electricity generation in India through 2050. Based on the results from five energy-economic modeling teams, the paper explores the implications of economic growth, power plant cooling policies, and electricity CO2 emissions reductions on water withdrawals and consumption. To isolate modeling differences, the five teams used harmonized assumptions regarding economic and population growth, the distribution of power plants by cooling technologies, and withdrawals and consumption intensities. The results demonstrate the different but potentially complementary implications of cooling technology policies and efforts to reduce CO2 emissions. The application of closed-loop cooling technologies substantially reduces water withdrawals but increases consumption. The water implications of CO2 emissions reductions, depend critically on the approach to these reductions. Focusing on wind and solar power reduces consumption and withdrawals; a focus on nuclear power increases both; and a focus on hydroelectric power could increase consumptive losses through evaporation.

Conducting a Withdrawal Survey.

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Aldridge, Sue; Rowley, Jennifer

2001-01-01

A survey at Edge Hill College of Higher Education in Canada, designed to be part of the mechanism for monitoring and evaluating the quality of the student experience, revealed that key factors influencing withdrawal were: course not as expected, traveling difficulties, institution not as expected, domestic difficulties, and financial difficulties.…

Estimates of ground-water pumpage from the Yakima River Basin aquifer system, Washington, 1960-2000

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Vaccaro, J.J.; Sumioka, S.S.

2006-01-01

Ground-water pumpage in the Yakima River Basin, Washington, was estimated for eight categories of use for 1960-2000 as part of an investigation to assess groundwater availability in the basin. Methods used, pumpage estimates, reliability of the estimates, and a comparison with appropriated quantities are described. The eight categories of pumpage were public water supply, self-supplied domestic (exempt wells), irrigation, frost protection, livestock and dairy operations, industrial and commercial, fish and wildlife propagation, and ground-water claims. Pumpage estimates were based on methods that varied by the category and primarily represent pumpage for groundwater rights. Washington State Department of Ecology’s digital database has 2,874 active ground-water rights in the basin that can withdraw an annual quantity of about 529,231 acre-feet during dry years. Irrigation rights are for irrigation of about 129,570 acres. All but 220 of the rights were associated with well drillers’ logs, allowing for a spatial representation of the pumpage. Five-hundred and sixty of the irrigation rights were estimated to be standby/reserve rights. During this study, another 30 rights were identified that were not in the digital database. These rights can withdraw an annual quantity of about 20,969 acre-feet; about 6,700 acre-feet of these rights are near but outside the basin. In 1960, total annual pumpage in the basin, excluding standby/reserve pumpage, was about 115,776 acre-feet. By 2000, total annual pumpage was estimated to be 395,096 acre-feet, and excluding the standby/reserve rights, the total was 312,284 acre-feet. Irrigation accounts for about 60 percent of the pumpage, followed by public water supply at about 12 percent. The smallest category of pumpage was for livestock use with pumpage estimated to be 6,726 acre-feet. Total annual pumpage in 2000 was about 430 cubic feet per second, which is about 11 percent of the surface-water demand. Maximum pumpage is in July

Concentration data for anthropogenic organic compounds in ground water, surface water, and finished water of selected community water systems in the United States, 2002-05

Science.gov (United States)

Carter, Janet M.; Delzer, Gregory C.; Kingsbury, James A.; Hopple, Jessica A.

2007-01-01

The National Water-Quality Assessment Program of the U.S. Geological Survey began implementing Source Water-Quality Assessments (SWQAs) in 2001 that focus on characterizing the quality of source water and finished water of aquifers and major rivers used by some of the larger community water systems (CWSs) in the United States. As used for SWQA studies, source water is the raw (ambient) water collected at the supply well prior to water treatment (for ground water) or the raw (ambient) water collected from the river near the intake (for surface water), and finished water is the water that is treated and ready to be delivered to consumers. Finished water is collected before entering the distribution system. SWQA studies are conducted in two phases, and the objectives of SWQA studies are twofold: (1) to determine the occurrence and, for rivers, seasonal changes in concentrations of a broad list of anthropogenic organic compounds (AOCs) in aquifers and rivers that have some of the largest withdrawals for drinking-water supply (phase 1), and (2) for those AOCs found to occur most frequently in source water, characterize the extent to which these compounds are present in finished water (phase 2). These objectives were met for SWQA studies by collecting ground-water and surface-water (source) samples and analyzing these samples for 258 AOCs during phase 1. Samples from a subset of wells and surface-water sites located in areas with substantial agricultural production in the watershed were analyzed for 19 additional AOCs, for a total of 277 compounds analyzed for SWQA studies. The 277 compounds were classified according to the following 13 primary use or source groups: (1) disinfection by-products; (2) fumigant-related compounds; (3) fungicides; (4) gasoline hydrocarbons, oxygenates, and oxygenate degradates; (5) herbicides and herbicide degradates; (6) insecticides and insecticide degradates; (7) manufacturing additives; (8) organic synthesis compounds; (9) pavement- and

Developing Sustainable Urban Water-Energy Infrastructures: Applying a Multi-Sectoral Social-Ecological-Infrastructural Systems (SEIS) Framework

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Ramaswami, A.

2016-12-01

Urban infrastructure - broadly defined to include the systems that provide water, energy, food, shelter, transportation-communication, sanitation and green/public spaces in cities - have tremendous impact on the environment and on human well-being (Ramaswami et al., 2016; Ramaswami et al., 2012). Aggregated globally, these sectors contribute 90% of global greenhouse gas (GHG) emissions and 96% of global water withdrawals. Urban infrastructure contributions to such impacts are beginning to dominate. Cities are therefore becoming the action arena for infrastructure transformations that can achieve high levels of service delivery while reducing environmental impacts and enhancing human well-being. Achieving sustainable urban infrastructure transitions requires: information about the engineered infrastructure, and its interaction with the natural (ecological-environmental) and the social sub-systems In this paper, we apply a multi-sector, multi-scalar Social-Ecological-Infrastructural Systems framework that describes the interactions among biophysical engineered infrastructures, the natural environment and the social system in a systems-approach to inform urban infrastructure transformations. We apply the SEIS framework to inform water and energy sector transformations in cities to achieve environmental and human health benefits realized at multiple scales - local, regional and global. Local scales address pollution, health, wellbeing and inequity within the city; regional scales address regional pollution, scarcity, as well as supply risks in the water-energy sectors; global impacts include greenhouse gas emissions and climate impacts. Different actors shape infrastructure transitions including households, businesses, and policy actors. We describe the development of novel cross-sectoral strategies at the water-energy nexus in cities, focusing on water, waste and energy sectors, in a case study of Delhi, India. Ramaswami, A.; Russell, A.G.; Culligan, P.J.; Sharma, K

Simulated effects of projected ground-water withdrawals in the Floridan aquifer system, greater Orlando metropolitan area, east-central Florida

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Murray, Louis C.; Halford, Keith J.

1999-01-01

Ground-water levels in the Floridan aquifer system within the greater Orlando metropolitan area are expected to decline because of a projected increase in the average pumpage rate from 410 million gallons per day in 1995 to 576 million gallons per day in 2020. The potential decline in ground-water levels and spring discharge within the area was investigated with a calibrated, steady-state, ground-water flow model. A wetter-than-average condition scenario and a drought-condition scenario were simulated to bracket the range of water-levels and springflow that may occur in 2020 under average rainfall conditions. Pumpage used to represent the drought-condition scenario totaled 865 million gallons per day, about 50 percent greater than the projected average pumpage rate in 2020. Relative to average 1995 steady-state conditions, drawdowns simulated in the Upper Floridan aquifer exceeded 10 and 25 feet for wet and dry conditions, respectively, in parts of central and southwest Orange County and in north Osceola County. In Seminole County, drawdowns of up to 20 feet were simulated for dry conditions, compared with 5 to 10 feet simulated for wet conditions. Computed springflow was reduced by 10 percent for wet conditions and by 38 percent for dry conditions, with the largest reductions (28 and 76 percent) occurring at the Sanlando Springs group. In the Lower Floridan aquifer, drawdowns simulated in southwest Orange County exceeded 20 and 40 feet for wet and dry conditions, respectively.

Acute pregabalin withdrawal: a case report and review of the literature

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Barrett JA

2015-05-01

Full Text Available Objective: Pregabalin is a commonly prescribed GABA analog most commonly used for the treatment of neuralgia. Recently, case reports on pregabalin have been published describing episodes that may be associated with withdrawal-like symptoms after extended or aggressive therapy. This report describes a case in which long term exposure of high dose pregabalin may have resulted in acute withdrawal, and outlines the subsequent medical management of these symptoms. Case Summary: A 61-year-old male presenting with severe agitation presumed to be withdrawal from long term and high dose exposure to pregabalin. Medical management included the use of haloperidol, diphenhydramine, lorazepam and the addition of clonidine over the course of several days for the pharmacological management of withdrawal symptoms. Discussion: Although case reports are available to guide clinicians in the recognition of acute pregabalin withdrawal, definitive evidence on how best to treat these patients remains severely limited. With an increase in the prescribing practices of pregabalin, insight into the acute management by fellow clinicians is further needed. Conclusion: Caution must be practiced when prescribing and educating patients on the use of pregabalin to prevent associated withdrawal-like symptoms. In addition, documentation by the medical community on methods utilized to treat pregabalin withdrawal syndromes remains crucial for the advancement of patient care. Benzodiazepines and clonidine are the current therapies that have been documented as potentially effective treatment modalities at this time.

Gut microbiota modulates alcohol withdrawal-induced anxiety in mice.

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Xiao, Hui-Wen; Ge, Chang; Feng, Guo-Xing; Li, Yuan; Luo, Dan; Dong, Jia-Li; Li, Hang; Wang, Haichao; Cui, Ming; Fan, Sai-Jun

2018-05-01

Excessive alcohol consumption remains a major public health problem that affects millions of people worldwide. Accumulative experimental evidence has suggested an important involvement of gut microbiota in the modulation of host's immunological and neurological functions. However, it is previously unknown whether enteric microbiota is implicated in the formation of alcohol withdrawal-induced anxiety. Using a murine model of chronic alcoholism and withdrawal, we examined the impact of alcohol consumption on the possible alterations of gut microbiota as well as alcohol withdrawal-induced anxiety and behavior changes. The 16S rRNA sequencing revealed that alcohol consumption did not alter the abundance of bacteria, but markedly changed the composition of gut microbiota. Moreover, the transplantation of enteric microbes from alcohol-fed mice to normal healthy controls remarkably shaped the composition of gut bacteria, and elicited behavioral signs of alcohol withdrawal-induced anxiety. Using quantitative real-time polymerase chain reaction, we further confirmed that the expression of genes implicated in alcohol addiction, BDNF, CRHR1 and OPRM1, was also altered by transplantation of gut microbes from alcohol-exposed donors. Collectively, our findings suggested a possibility that the alterations of gut microbiota composition might contribute to the development of alcohol withdrawal-induced anxiety, and reveal potentially new etiologies for treating alcohol addiction. Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved.

Death Valley regional ground-water flow system, Nevada and California -- hydrogeologic framework and transient ground-water flow model

Science.gov (United States)

Belcher, Wayne R.

2004-01-01

provided by acquiring additional data, by reevaluating existing data using current technology and concepts, and by refining earlier interpretations to reflect the current understanding of the regional ground-water flow system. Ground-water flow in the Death Valley region is composed of several interconnected, complex ground-water flow systems. Ground-water flow occurs in three subregions in relatively shallow and localized flow paths that are superimposed on deeper, regional flow paths. Regional ground-water flow is predominantly through a thick Paleozoic carbonate rock sequence affected by complex geologic structures from regional faulting and fracturing that can enhance or impede flow. Spring flow and evapotranspiration (ET) are the dominant natural ground-water discharge processes. Ground water also is withdrawn for agricultural, commercial, and domestic uses. Ground-water flow in the DVRFS was simulated using MODFLOW-2000, a 3D finite-difference modular ground-water flow modeling code that incorporates a nonlinear least-squares regression technique to estimate aquifer parameters. The DVRFS model has 16 layers of defined thickness, a finite-difference grid consisting of 194 rows and 160 columns, and uniform cells 1,500 m on each side. Prepumping conditions (before 1913) were used as the initial conditions for the transient-state calibration. The model uses annual stress periods with discrete recharge and discharge components. Recharge occurs mostly from infiltration of precipitation and runoff on high mountain ranges and from a small amount of underflow from adjacent basins. Discharge occurs primarily through ET and spring discharge (both simulated as drains) and water withdrawal by pumping and, to a lesser amount, by underflow to adjacent basins, also simulated by drains. All parameter values estimated by the regression are reasonable and within the range of expected values. The simulated hydraulic heads of the final calibrated transient model gener

The Visible Burrow System : A behavioral paradigm to assess sociability and social withdrawal in BTBR and C57BL/6J mice strains

NARCIS (Netherlands)

Bove, Maria; Ike, Kevin; Eldering, Adriaan; Buwalda, Bauke; de Boer, Sietse F; Morgese, Maria Grazia; Schiavone, Stefania; Cuomo, Vincenzo; Trabace, Luigia; Kas, Martien J H

2018-01-01

Disrupted sociability and consequent social withdrawal are (early) symptoms of a wide variety of neuropsychiatric diseases, such as schizophrenia, autism spectrum disorders, depressive disorders and Alzheimer's disease. The paucity of objective measures to translationally assess social withdrawal

Analysis of key thresholds leading to upstream dependencies in global transboundary water bodies

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Munia, Hafsa Ahmed; Guillaume, Joseph; Kummu, Matti; Mirumachi, Naho; Wada, Yoshihide

2017-04-01

Transboundary water bodies supply 60% of global fresh water flow and are home to about 1/3 of the world's population; creating hydrological, social and economic interdependencies between countries. Trade-offs between water users are delimited by certain thresholds, that, when crossed, result in changes in system behavior, often related to undesirable impacts. A wide variety of thresholds are potentially related to water availability and scarcity. Scarcity can occur because of the country's own water use, and that is potentially intensified by upstream water use. In general, increased water scarcity escalates the reliance on shared water resources, which increases interdependencies between riparian states. In this paper the upstream dependencies of global transboundary river basins are examined at the scale of sub-basin areas. We aim to assess how upstream water withdrawals cause changes in the scarcity categories, such that crossing thresholds is interpreted in terms of downstream dependency on upstream water availability. The thresholds are defined for different types of water availability on which a sub-basin relies: - reliable local runoff (available even in a dry year), - less reliable local water (available in the wet year), - reliable dry year inflows from possible upstream area, and - less reliable wet year inflows from upstream. Possible upstream withdrawals reduce available water downstream, influencing the latter two water availabilities. Upstream dependencies have then been categorized by comparing a sub-basin's scarcity category across different water availability types. When population (or water consumption) grows, the sub-basin satisfies its needs using less reliable water. Thus, the factors affecting the type of water availability being used are different not only for each type of dependency category, but also possibly for every sub- basin. Our results show that, in the case of stress (impacts from high use of water), in 104 (12%) sub- basins out of

A rare case of complicated opioid withdrawal in delirium without convulsions

OpenAIRE

B Neeraj Raj; N Manamohan; Divya Hegde; Chandrashekar B Huded; Johnson Pradeep

2017-01-01

Opioids are one of the commonly abused substances in India. Opioid withdrawal symptoms classically include severe muscle cramps, bone aches, autonomic symptoms, anxiety, restlessness, insomnia, and temperature dysregulation. However, reports of cases with delirium during withdrawal are few. A 25-year-old male with severe opioid withdrawal symptoms developed delirium. Investigations were normal. There were no comorbidities, no significant past history and family history. Patient treated for op...

An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice.

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Metten, Pamela; Schlumbohm, Jason P; Huang, Lawrence C; Greenberg, Gian D; Hack, Wyatt R; Spence, Stephanie E; Crabbe, John C

2018-05-01

Despite acceptance that risk for alcohol-use disorder (AUD) has a large genetic component, the identification of genes underlying various components of risk for AUD has been hampered in humans, in part by the heterogeneity of expression of the phenotype. One aspect of AUD is physical dependence. Alcohol withdrawal is a serious consequence of alcohol dependence with multiple symptoms, many of which are seen in multiple species, and can be experienced over a wide-ranging time course. In the present three studies, we developed a battery of withdrawal tests in mice, examining behavioral symptoms from multiple domains that could be measured over time. To permit eventual use of the battery in different strains of mice, we used male and female mice of a genetically heterogeneous stock developed from intercrossing eight inbred strains. Withdrawal symptoms were assessed using commonly used tests after administration of ethanol in vapor for 72 continuous hours. We found significant effects of ethanol withdrawal versus air-breathing controls on nearly all symptoms, spanning 4 days following ethanol vapor inhalation. Withdrawal produced hypothermia, greater neurohyperexcitability (seizures and tremor), anxiety-like behaviors using an apparatus (such as reduced transitions between light and dark compartments), anhedonia (reduced sucrose preference), Straub tail, backward walking, and reductions in activity; however, there were no changes in thermal pain sensitivity, hyper-reactivity to handling, or anxiety-like emergence behaviors in other apparatus. Using these data, we constructed a refined battery of withdrawal tests. Individual differences in severity of withdrawal among different tests were weakly correlated at best. This battery should be useful for identifying genetic influences on particular withdrawal behaviors, which should reflect the influences of different constellations of genes. Published by Elsevier Inc.

Dansyl-PQRamide, a putative antagonist of NPFF receptors, reduces anxiety-like behavior of ethanol withdrawal in a plus-maze test in rats.

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Kotlinska, Jolanta; Pachuta, Agnieszka; Bochenski, Marcin; Silberring, Jerzy

2009-06-01

Much evidence indicates that endogenous opioid peptides are involved in effects caused by ethanol. The aim of the present study was to determine whether dansyl-PQR amide, a putative antagonist of receptors for an anti-opioid peptide-neuropeptide FF (NPFF) could affect anxiety-like behavior measured during withdrawal from acute-, and chronic ethanol administration in the elevated plus maze test in rats. Our study indicated that intracerebroventricular (i.c.v.) administration of dansyl-PQRamide (2.4 and 4.8 nmol) reversed anxiety-like behavior measured as a percent time spent in the open arms, and a percent open arm entries onto the open arms in the elevated plus-maze test in rats. These effects were inhibited by NPFF (10 and/or 20 nmol, i.c.v.) in the experiments performed during withdrawal from acute- and chronic ethanol administration. During withdrawal from acute ethanol, naloxone (1mg/kg, i.p.), a nonselective opioid receptor antagonist, attenuated only an increased percent time spent in the open arms induced by dansyl-PQR amide (4.8 nmol). Dansyl-PQR amide, NPFF and naloxone given alone to naive rats did not have influence on spontaneous locomotor activity of animals. Furthermore, NPFF potentiated anxiety-like behavior during withdrawal from chronic, but not acute, ethanol administration in rats. Our data suggest that NPFF system is involved in regulation of affective symptoms of ethanol withdrawal. It seems that involvement of the NPFF system in ethanol withdrawal anxiety-like behavior is associated with regulation of the opioid system activity.

Impact of litter Salmonella status during feed withdrawal on Salmonella recovery from the broiler crop and ceca.

Science.gov (United States)

Buhr, R J; Bourassa, D V; Hinton, A; Fairchild, B D; Ritz, C W

2017-12-01

were switched between Salmonella challenge pens. However, when non-challenged broilers were placed into the Salmonella challenge pens and commingled during the 12-hour feed and water withdrawal period, it was possible to recover the pen litter Salmonella from the ceca at a low level of 5% (2/40). Published by Oxford University Press on behalf of Poultry Science Association 2017.

27 CFR 19.532 - Withdrawals of spirits for use in wine production.

Science.gov (United States)

2010-04-01

... use in wine production. 19.532 Section 19.532 Alcohol, Tobacco Products and Firearms ALCOHOL AND... Withdrawals Withdrawal of Spirits Without Payment of Tax § 19.532 Withdrawals of spirits for use in wine production. Wine spirits may be withdrawn to a bonded wine cellar without payment of tax for use in wine...

Source Water Management for Disinfection By-Product Control using New York City's Operations Support Tool and On-Line Monitoring

Science.gov (United States)

Weiss, W. J.; Becker, W.; Schindler, S.

2012-12-01

The United States Environmental Protection Agency's 2006 Stage 2 Disinfectant / Disinfection Byproduct Rule (DBPR) for finished drinking waters is intended to reduce overall DBP levels by limiting the levels of total trihalomethanes (TTHM) and five of the haloacetic acids (HAA5). Under Stage 2, maximum contaminant levels (MCLs), 80 μg/L for TTHM and 60 μg/L for HAA5, are based on a locational running annual average for individual sites instead of as the system-wide quarterly running annual average of the Stage 1 DBPR. This means compliance will have to be met at sampling locations of peak TTHM and HAA5 concentrations rather than an average across the entire system. Compliance monitoring under the Stage 2 DBPR began on April 1, 2012. The New York City (NYC) Department of Environmental Protection (DEP) began evaluating potential impacts of the Stage 2 DBPR on NYC's unfiltered water supply in 2002 by monitoring TTHM and HAA5 levels at various locations throughout the distribution system. Initial monitoring indicated that HAA5 levels could be of concern in the future, with the potential to intermittently violate the Stage 2 DBPR at specific locations, particularly those with high water age. Because of the uncertainty regarding the long-term prospect for compliance, DEP evaluated alternatives to ensure compliance, including operational changes (reducing chlorine dose, changing flow configurations to minimize water age, altering pH, altering source water withdrawals); changing the residual disinfectant from free chlorine to chloramines; and engineered treatment alternatives. This paper will discuss the potential for using DEP's Operations Support Tool (OST) and enhanced reservoir monitoring to support optimization of source water withdrawals to minimize finished water DBP levels. The OST is a state-of-the-art decision support system (DSS) to provide computational and predictive support for water supply operations and planning. It incorporates a water supply system

Screening of sustainable groundwater sources for integration into a regional drought-prone water supply system

Directory of Open Access Journals (Sweden)

H. Lucas

2009-07-01

Full Text Available This paper reports on the qualitative and quantitative screening of groundwater sources for integration into the public water supply system of the Algarve, Portugal. The results are employed in a decision support system currently under development for an integrated water resources management scheme in the region. Such a scheme is crucial for several reasons, including the extreme seasonal and annual variations in rainfall, the effect of climate change on more frequent and long-lasting droughts, the continuously increasing water demand and the high risk of a single-source water supply policy. The latter was revealed during the severe drought of 2004 and 2005, when surface reservoirs were depleted and the regional water demand could not be met, despite the drilling of emergency wells.

For screening and selection, quantitative criteria are based on aquifer properties and well yields, whereas qualitative criteria are defined by water quality indices. These reflect the well's degree of violation of drinking water standards for different sets of variables, including toxicity parameters, nitrate and chloride, iron and manganese and microbiological parameters. Results indicate the current availability of at least 1100 l s⁻¹ of high quality groundwater (55% of the regional demand, requiring only disinfection (900 l s⁻¹ or basic treatment, prior to human consumption. These groundwater withdrawals are sustainable when compared to mean annual recharge, considering that at least 40% is preserved for ecological demands. A more accurate and comprehensive analysis of sustainability is performed with the help of steady-state and transient groundwater flow simulations, which account for aquifer geometry, boundary conditions, recharge and discharge rates, pumping activity and seasonality. They permit an advanced analysis of present and future scenarios and show that increasing water demands and decreasing rainfall will make

Evolution of Metabolic Abnormalities in Alcoholic Patients during Withdrawal

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X. Vandemergel

2015-01-01

Full Text Available Chronic alcohol intoxication is accompanied by metabolic abnormalities. Evolution during the early withdrawal period has been poorly investigated. The aim of this study was to determine the evolution of metabolic parameters during alcohol withdrawal. Patients and Methods. Thirty-three patients admitted in our department for alcohol withdrawal were prospectively included. Results. Baseline hypophosphatemia was found in 24% of cases. FEPO4 was reduced from 14.2 ± 9% at baseline to 7.3 ± 4.2% at day 3 (Pnl, respectively. No correlation was found between the sodium and CPK levels (P=0.75 nor between the CPK level and the amount of alcohol ingested (rs = 0.084, P=0.097. Baseline urate level was elevated and returned to normal after three days. Baseline magnesium concentration was normal and stable over time. Conclusion. Chronic alcohol intoxication was accompanied by phosphaturia, rapidly reversible after alcohol withdrawal and inversely correlated with albuminemia, slight hyponatremia, low levels of 25 hydroxy vitamin D, elevated CPK level in about 30% of women, and hyperuricemia with rapid normalization.

It's self defense: how perceived discrimination promotes employee withdrawal.

Science.gov (United States)

Volpone, Sabrina D; Avery, Derek R

2013-10-01

Integrating theory on stress, stigma, and coping, the present study sheds light on how employees react to perceived discrimination (PD) in the workplace. Using three national samples, we found that PD based on race, sex, age, family obligation, and sexual orientation related to physical withdrawal (i.e., lateness, absenteeism,and intent to quit) indirectly through psychological withdrawal (i.e., burnout and engagement) such that PD corresponded in less engagement and more burnout, which related to increased lateness, absenteeism, and intent to quit [corrected].Further, these indirect relationships were moderated by employees' coping mechanisms with those who were more apt to change the situation or to avoid the stressor exhibiting weaker relationships between PD and psychological withdrawal. Though each of these studies is cross-sectional in nature and therefore cannot provide strong evidence of causal ordering of the variables in our model, the replication and extension of results over three databases and multiple forms of discrimination, coping, psychological, and physical withdrawal demonstrates that understanding the relationships explored in these studies can aid researchers and practitioners in enhancing employee quality of life and productivity.

Differentiating Delirium From Sedative/Hypnotic-Related Iatrogenic Withdrawal Syndrome: Lack of Specificity in Pediatric Critical Care Assessment Tools.

Science.gov (United States)

Madden, Kate; Burns, Michele M; Tasker, Robert C

2017-06-01

To identify available assessment tools for sedative/hypnotic iatrogenic withdrawal syndrome and delirium in PICU patients, the evidence supporting their use, and describe areas of overlap between the components of these tools and the symptoms of anticholinergic burden in children. Studies were identified using PubMed and EMBASE from the earliest available date until July 3, 2016, using a combination of MeSH terms "delirium," "substance withdrawal syndrome," and key words "opioids," "benzodiazepines," "critical illness," "ICU," and "intensive care." Review article references were also searched. Human studies reporting assessment of delirium or iatrogenic withdrawal syndrome in children 0-18 years undergoing critical care. Non-English language, exclusively adult, and neonatal intensive care studies were excluded. References cataloged by study type, population, and screening process. Iatrogenic withdrawal syndrome and delirium are both prevalent in the PICU population. Commonly used scales for delirium and iatrogenic withdrawal syndrome assess signs and symptoms in the motor, behavior, and state domains, and exhibit considerable overlap. In addition, signs and symptoms of an anticholinergic toxidrome (a risk associated with some common PICU medications) overlap with components of these scales, specifically in motor, cardiovascular, and psychiatric domains. Although important studies have demonstrated apparent high prevalence of iatrogenic withdrawal syndrome and delirium in the PICU population, the overlap in these scoring systems presents potential difficulty in distinguishing syndromes, both clinically and for research purposes.

Data mining of Students Withdrawal at University of Tehran, Focusing on Fee Paid Students (to prevent customer churn

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Saied Ali Akbar Ahmadi

2015-06-01

Full Text Available Student withdrawal in higher education is one the important challenges in universities. This paper considers the admission of fee paid students as a business and their withdrawals as customer churn. The aim is to investigate the attrition and predicted risk of attrition to adapt interventionist polices deterrent. This study is a descriptive an applicable technique that uses quantitative and qualitative data. It uses Crisp technology of data mining. The data are derived from educational system of University of Tehran including 21420 fee paid students accepted at 2010 to 2014. The main goal is to analyze the behavior that is at risk of attrition and withdrawal. After data analyze and construction of predictive modeling, the probability table of attrition and regression model will be presented. The final results show that the first and second semester (especially the age range 24-31 of M.Sc students are the most likely risk of withdrawal of happening.

Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats.

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Kumar, Jaya; Hapidin, Hermizi; Bee, Yvonne-Tee Get; Ismail, Zalina

2013-11-26

Abstinence from chronic ethanol consumption leads to the manifestation of a variety of symptoms attributed to central nervous system hyperexcitability, such as increased irritability, anxiety, and restlessness. Recent studies have demonstrated the importance of metabotropic glutamate receptor 5 (mGluR5) in addictive behaviours. This study investigates the effects of the mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) on ethanol withdrawal induced anxiety using two behavioural paradigms. Male Wistar rats were fed a Modified Liquid Diet (MLD) containing low fat cow milk, sucrose, and maltodextrin with a gradual introduction of 2.4%, 4.8% and 7.2% ethanol for 20 days. Six hours into ethanol withdrawal, the rats were intraperitoneally injected with normal saline and MPEP (2.5, 5.0, 10, 20, 30 mg/kg) and were assessed for ethanol withdrawal induced anxiety-like syndrome using an automated elevated plus maze and an open field. MPEP at 10 mg/kg significantly attenuated ethanol withdrawal induced anxiety without any compromising effects on locomotor activities. Despite reversing several indices of ethanol withdrawal induced anxiety in both the elevated plus maze and the open field, low doses of MPEP (2.5, 5 mg/kg) significantly compromised the locomotor activities of ethanol withdrawn rats. High doses of MPEP (20 and 30 mg/kg) significantly attenuated withdrawal anxiety when tested in the elevated plus maze but not in the open field. Administration of MPEP (2.5, 5, 10, 20, 30 mg/kg) has no significant compromising effect on the locomotor activities of ethanol naïve rats. Despite significantly reducing withdrawal anxiety in both behavioural paradigms at 10 mg/kg, the compromising effects of low and high doses of MPEP must be further explored along with the therapeutic efficiency of this drug for relieving withdrawal induced anxiety.

Object relations, reality testing, and social withdrawal in schizophrenia and bipolar disorder.

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Hansen, Charlotte Fredslund; Torgalsbøen, Anne-Kari; Røssberg, Jan Ivar; Romm, Kristin Lie; Andreassen, Ole Andreas; Bell, Morris D; Melle, Ingrid

2013-03-01

In this study, we investigated the relationships between observed social withdrawal (Positive and Negative Syndrome Scale [PANSS] Passive Social Withdrawal and PANSS Active Social Avoidance), subjectively experienced social withdrawal (Social Functioning Scale [SFS] Withdrawal and SFS Interpersonal Behavior), and their associations to the underlying psychological patterns of Object Relations and Reality Testing. Patients with schizophrenia (n = 55) and bipolar disorder (n = 51) from the ongoing Thematically Organized Psychosis project, Oslo University Hospital, Norway, were evaluated using the Bell Object Relations and Reality Testing Inventory, the PANSS, and the SFS. Object relations and reality testing subscales related differentially to PANSS Passive Social Withdrawal and PANSS Active Social Avoidance. These two measures, together with the level of alienation, explained a significant amount of variance in self-experienced social dysfunction. Findings reveal the multidimensional nature of social dysfunction in severe mental disorders.

Life cycle water use of energy production and its environmental impacts in China.

Science.gov (United States)

Zhang, Chao; Anadon, Laura Diaz

2013-12-17

The energy sector is a major user of fresh water resources in China. We investigate the life cycle water withdrawals, consumptive water use, and wastewater discharge of China's energy sectors and their water-consumption-related environmental impacts, using a mixed-unit multiregional input-output (MRIO) model and life cycle impact assessment method (LCIA) based on the Eco-indicator 99 framework. Energy production is responsible for 61.4 billion m(3) water withdrawals, 10.8 billion m(3) water consumption, and 5.0 billion m(3) wastewater discharges in China, which are equivalent to 12.3%, 4.1% and 8.3% of the national totals, respectively. The most important feature of the energy-water nexus in China is the significantly uneven spatial distribution of consumptive water use and its corresponding environmental impacts caused by the geological discrepancy among fossil fuel resources, fresh water resources, and energy demand. More than half of energy-related water withdrawals occur in the east and south coastal regions. However, the arid north and northwest regions have much larger water consumption than the water abundant south region, and bear almost all environmental damages caused by consumptive water use.

Residents' perceptions about surrogate decision makers' financial conflicts of interest in ventilator withdrawal.

Science.gov (United States)

Wastila, Lisa J; Farber, Neil J

2014-05-01

There have been no studies to date that examine physicians' decisions to withdraw life-sustaining treatment for patients based on their surrogates' financial gain. The authors' objective was to ascertain physician attitudes about withdrawing life-sustaining treatment when financial considerations are involved. A survey was developed and pretested containing eight scenarios in which a terminally ill patient's spouse had a decision to make regarding withdrawal of the ventilator, which was deemed medically futile. Nested variables included agreement or disagreement between the spouse and patient, decision to withdraw or continue the ventilator, and financial gain or no financial gain for the spouse. The authors surveyed all internal medicine residents at the University of California, San Diego in the autumn of 2011 and winter of 2012. The responses on each of the three variables for which respondents were likely to withdraw the ventilator were analyzed via student's t-tests. Residents were more likely to withdraw the ventilator when requested to do so than when it was requested to be continued. They were also more likely to withdraw the ventilator when there was agreement in the decision between the spouse and the patient. Residents were more likely to withdraw the ventilator when the spouse would not benefit financially. Internal medicine residents make some decisions about whether to withdraw life-sustaining treatment based on financial considerations. There needs to be ongoing communication with residents about end-of-life decisions where conflicts may exist between the surrogate decision makers and patients or physicians.

The nature of the scientific evidence leading to drug withdrawals for pharmacovigilance reasons in France.

Science.gov (United States)

Olivier, Pascale; Montastruc, Jean-Louis

2006-11-01

Because of design, objectives and number of included subjects, clinical studies are insufficient to assess the safety of new drugs. Sometimes, serious adverse drug reactions (ADRs) led to withdrawal of the drug from the market after their approval. The objective of our study was to determine the scientific evidences leading to drug withdrawal for pharmacovigilance reasons in France. Data coming from French Health Products Safety Agency, literature and Toulouse Pharmacovigilance Center allowed to identify all drugs withdrawn from the French market for pharmacovigilance reasons from 1998 to 2004. We classified data according to their study design (Randomized Clinical Trial [RCT], case serie or case report, case-control study, cohort study, observational study, animal study), the organ/system affected and the type of ADR. A total of 21 drugs were withdrawn for safety reasons between 1998 and 2004 in France. The most frequent ADRs were hepatic (n = 7), cardiovascular (n = 4) or neurological (n = 3) ones. Eleven withdrawals were due to type-B ('unexpected') reactions (52%). For 19 out of 21 drugs, scientific evidence leading to drug withdrawal came from spontaneous case reports (or case series). Among these, case reports were the sole evidence in 12 cases. Withdrawals were based on evidence from case reports in combination with case-control or cohort study in four cases, in combination with observational study in two cases or in combination with animal study in two other cases. In only one case, a RCT supported the decision. This study underlines the importance of spontaneous case reports in detecting signals and supporting withdrawal of drug for pharmacovigilance reasons in France. Health authorities suffer from lack of comparative data resource. In this perspective, a pharmaco-epidemiological population-based database could represent a helpful tool to both generate and test safety hypotheses.

8 CFR 246.4 - Immigration judge's authority; withdrawal and substitution.

Science.gov (United States)

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Immigration judge's authority; withdrawal... IMMIGRATION REGULATIONS RESCISSION OF ADJUSTMENT OF STATUS § 246.4 Immigration judge's authority; withdrawal and substitution. In any proceeding conducted under this part, the immigration judge shall have...

20 CFR 416.360 - Cancellation of a request to withdraw.

Science.gov (United States)

2010-04-01

....360 Section 416.360 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Filing of Applications Withdrawal of Application § 416.360... received after we have approved the withdrawal, the cancellation request is filed no later than 60 days...

Trajectories of Social Withdrawal from Middle Childhood to Early Adolescence

Science.gov (United States)

Oh, Wonjung; Rubin, Kenneth H.; Bowker, Julie C.; Booth-LaForce, Cathryn; Rose-Krasnor, Linda; Laursen, Brett

2008-01-01

Heterogeneity and individual differences in the developmental course of social withdrawal were examined longitudinally in a community sample (N = 392). General Growth Mixture Modeling (GGMM) was used to identify distinct pathways of social withdrawal, differentiate valid subgroup trajectories, and examine factors that predicted change in…