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Sample records for warburg minerva center

  1. The Minerva process

    International Nuclear Information System (INIS)

    Detilleux, E.; Eschrich, H.; Geel, J. van.

    1978-07-01

    The objective of the work presented in this paper is to develop an advanced technology for the conversion of the highly radiactive liquid wastes from fuel reprocessing into solid products of properties ensuring the safe isolation of the contained radionuclides from the biosphere. In pursuing this objective, the chemical and technical investigations led to the development of a process, called MINERVA, which was demonstrated in cold laboratory scale tests to be applicable not only to the solidification of various types of liquid high-level waste but also to all kinds of liquid aqueous medium-level and organic wastes generated in a Purex reprocessing plant. The Minerva process is carried out in two main operation steps: the solidification of the different waste solutions, either individually or mixed, to mineral-like granular phosphate compounds at about 500 deg C using a stirred-bed reactor; and the conditioning of the granulates according to their chemical composition and generated specific heat into either a monlithic phosphate glass-ceramic block by using the in-can melting technique, or by incorporating them into a metal matrix. (author)

  2. The MINERVA Software Development Process

    Science.gov (United States)

    Narkawicz, Anthony; Munoz, Cesar A.; Dutle, Aaron M.

    2017-01-01

    This paper presents a software development process for safety-critical software components of cyber-physical systems. The process is called MINERVA, which stands for Mirrored Implementation Numerically Evaluated against Rigorously Verified Algorithms. The process relies on formal methods for rigorously validating code against its requirements. The software development process uses: (1) a formal specification language for describing the algorithms and their functional requirements, (2) an interactive theorem prover for formally verifying the correctness of the algorithms, (3) test cases that stress the code, and (4) numerical evaluation on these test cases of both the algorithm specifications and their implementations in code. The MINERVA process is illustrated in this paper with an application to geo-containment algorithms for unmanned aircraft systems. These algorithms ensure that the position of an aircraft never leaves a predetermined polygon region and provide recovery maneuvers when the region is inadvertently exited.

  3. Walker-Warburg syndrome

    Directory of Open Access Journals (Sweden)

    Schachter Harry

    2006-08-01

    Full Text Available Abstract Walker-Warburg Syndrome (WWS is a rare form of autosomal recessive congenital muscular dystrophy associated with brain and eye abnormalities. WWS has a worldwide distribution. The overall incidence is unknown but a survey in North-eastern Italy has reported an incidence rate of 1.2 per 100,000 live births. It is the most severe form of congenital muscular dystrophy with most children dying before the age of three years. WWS presents at birth with generalized hypotonia, muscle weakness, developmental delay with mental retardation and occasional seizures. It is associated with type II cobblestone lissencephaly, hydrocephalus, cerebellar malformations, eye abnormalities and congenital muscular dystrophy characterized by hypoglycosylation of α-dystroglycan. Several genes have been implicated in the etiology of WWS, and others are as yet unknown. Several mutations were found in the Protein O-Mannosyltransferase 1 and 2 (POMT1 and POMT2 genes, and one mutation was found in each of the fukutin and fukutin-related protein (FKRP genes. Laboratory investigations usually show elevated creatine kinase, myopathic/dystrophic muscle pathology and altered α-dystroglycan. Antenatal diagnosis is possible in families with known mutations. Prenatal ultrasound may be helpful for diagnosis in families where the molecular defect is unknown. No specific treatment is available. Management is only supportive and preventive.

  4. Minerva User Manual Version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    J.J. Cogliati; M. L. Milvich; D. E. Wessol; C. A. Wemple

    2007-03-01

    MINERVA (Modality-Inclusive Environment for Radiotherapeutic Variable Analysis) is a Java-based patient-centric radiation treatment planning system (RTPS) for computational dosimetry and treatment planning in emerging areas of radiotherapy for cancer and other diseases. MINERVA was primarily developed at the Idaho National Laboratory (INL) and Montana State University (MSU). MINERVA allows the radiotherapist to make side-by-side comparison of plans for multiple treatment modalities with a common anatomical basis for the computational geometry, calculate doses for combinations of different radiotherapy modalities, and perform dose analysis and reporting functions. This provides the therapist with a consistent basis for selecting the modality or combination of modalities to use for treatment of the patient. MINERVA employs an integrated, lightweight plug-in architecture to accommodate multi-modal treatment planning using standard interface components. The MINERVA design facilitates integration of improved or emerging treatment planning technologies. MINERVA consists of the basic radiation treatment planning software modules managed by a consistent patient interface for developing multi-modal radiotherapy patient treatment plans. One of MINERVA's main functions is to provide a graphical environment for constructing and displaying uniform volume-element-based solid models derived from medical images. These solid models form the geometric basis of the target areas for the radiation transport model.

  5. Recent Results from MINERvA

    Energy Technology Data Exchange (ETDEWEB)

    Fields, Laura [Fermilab

    2016-12-21

    The MINERvA collaboration is currently engaged in a broad program of neutrino-nucleus interaction measurements. Several recent measurements of interest to the accelerator-based oscillation community are presented. These include measurements of quasi-elastic scattering, diffractive pion production, kaon production and comparisons of interaction cross sections across nuclei. A new measurement of the NuMI neutrino beam flux that incorporates both external hadro-production data and MINERvA detector data is also presented.

  6. Recent Results from MINERvA

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Jonathan [Santa Maria U., Valparaiso

    2014-09-01

    MINERvA (Main INjector ExpeRiment for v-A) is a few-GeV neutrino nucleus scattering experiment at Fermilab using various nuclei as targets. The experiment provides measurements of neutrino and anti-neutrino cross sections off of nuclear targets which are important for neutrino oscillation experiments and the probing of the nuclear medium.Presented are recent results from MINERvA on quasi-elastic, inclusive charged-current neutrino scattering, and pion production processes.

  7. Warburg, Shakespeare e la prima impresa

    Directory of Open Access Journals (Sweden)

    Alice Barale

    2012-12-01

    Full Text Available With his fight against the sea monster Medusa, Perseus embodies for Warburg the “world-directed energy”. Warburg's “energetic  aesthetics” could be interpreted then as nothing but another version of the hypertrophic, despotic subject Ferraris has often written about. We will show it that is not the case by considering the relationship that Warburg draws between Perseus and Hamlet.

  8. Nuclear Physics with MINERvA

    International Nuclear Information System (INIS)

    Tice, Brian G.

    2011-01-01

    MINERvA is a precision neutrino experiment designed to improve our understanding of the neutrino-nucleus interaction. The experiment uses a fully active scintillation detector to allow full event reconstruction and includes nuclear targets helium, water, carbon, iron and lead. Here we describe the first steps in measuring lead to iron to carbon cross section ratios.

  9. Maria Minerva - Eesti esimene hüpnagoogilise popi staar / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2011-01-01

    Maria Minerva nime all tegutsevast Londonis õppivast muusikust Maria Juurest. Muusiku USA-s plaadifirma Not Not Fun poolt välja antud helikassetist Maria Minerva "Tallinn At Down" ja heliplaadist Maria Minerva "Noble Savage"

  10. MINERVA, qualification of dissimilar welds for HTR-application

    International Nuclear Information System (INIS)

    Baumann, B.; Gnirss, G.; Neureuther, H.; Schneider, K.

    1989-01-01

    The component test ''MINERVA'' is part of an overall concept to qualify dissimilar welds in pipings of advanced gas-cooled high temperature reactors. ''MINERVA'' is designed for a testing time of 20000 h. The experiment started in January 1987. The paper describes the concept, the manufacuring parameters including the basis of selection of materials and welding procedures. The experiment MINERVA and the operating conditions are described. (orig.)

  11. Minerva: An Integrated Geospatial/Temporal Toolset for Real-time Science Decision Making and Data Collection

    Science.gov (United States)

    Lees, D. S.; Cohen, T.; Deans, M. C.; Lim, D. S. S.; Marquez, J.; Heldmann, J. L.; Hoffman, J.; Norheim, J.; Vadhavk, N.

    2016-12-01

    Minerva integrates three capabilities that are critical to the success of NASA analogs. It combines NASA's Exploration Ground Data Systems (xGDS) and Playbook software, and MIT's Surface Exploration Traverse Analysis and Navigation Tool (SEXTANT). Together, they help to plan, optimize, and monitor traverses; schedule and track activity; assist with science decision-making and document sample and data collection. Pre-mission, Minerva supports planning with a priori map data (e.g., UAV and satellite imagery) and activity scheduling. During missions, xGDS records and broadcasts live data to a distributed team who take geolocated notes and catalogue samples. Playbook provides live schedule updates and multi-media chat. Post-mission, xGDS supports data search and visualization for replanning and analysis. NASA's BASALT (Biologic Analog Science Associated with Lava Terrains) and FINESSE (Field Investigations to Enable Solar System Science and Exploration) projects use Minerva to conduct field science under simulated Mars mission conditions including 5 and 15 minute one-way communication delays. During the recent BASALT-FINESSE mission, two field scientists (EVA team) executed traverses across volcanic terrain to characterize and sample basalts. They wore backpacks with communications and imaging capabilities, and carried field portable spectrometers. The Science Team was 40 km away in a simulated mission control center. The Science Team monitored imaging (video and still), spectral, voice, location and physiological data from the EVA team via the network from the field, under communication delays. Minerva provided the Science Team with a unified context of operations at the field site, so they could make meaningful remote contributions to the collection of 10's of geotagged samples. Minerva's mission architecture will be presented with technical details and capabilities. Through the development, testing and application of Minerva, we are defining requirements for the

  12. Recent Results From MINERvA

    Energy Technology Data Exchange (ETDEWEB)

    Patrick, Cheryl [Northwestern U.

    2015-05-13

    The MINERvA detector is situated in Fermilab's NuMI beam, which provides neutrinos and antineutrinos in the 1-20 GeV range. It is designed to make precision cross-section measurements for scattering processes on various nuclei. These proceedings summarize the differential cross-section distributions measured for several different processes. Comparison of these with various models hints at additional nuclear effects not included in common simulations. These results will help constrain generators' nuclear models and reduce systematic uncertainties on their predictions. An accurate cross-section model, with minimal uncertainties, is vital to oscillation experiments.

  13. Warburg effect—damping of electromagnetic oscillations

    Czech Academy of Sciences Publication Activity Database

    Pokorný, Jiří; Pokorný, Jan; Borodavka, Fedir

    2017-01-01

    Roč. 36, č. 3 (2017), s. 270-278 ISSN 1536-8378 R&D Projects: GA ČR GA16-12757S Institutional support: RVO:68378271 Keywords : Warburg effect * mitochondrial dysfunction * water ordering * mitochondrial membrane potential * biological electromagnetic activity * cancer Subject RIV: BO - Biophysics OBOR OECD: Biophysics Impact factor: 1.272, year: 2016

  14. MINERvA - neutrino nucleus cross section experiment

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    Recent results from MINERvA, a neutrino cross section experiment at Fermilab, are presented. MINERVA has the goal of providing precision results which will have important impact on oscillation experiments.  Initial data runs for muon neutrino and antineutrino beams of ~3.5 GeV have produced a large number of new results. This seminar will introduce the experiment and describe results for quasielastic, pion production, and inclusive cross sections.

  15. Aby Warburg, Images and Exhibitions. Aby Warburg, Bilderreihen und Ausstellungen edited by Uwe Fleckner and Isabelle Woldt, Akademie Verlag, 2012

    Directory of Open Access Journals (Sweden)

    Matthew Rampley

    2012-12-01

    Full Text Available This article reviews the latest volume in the collected works of Aby Warburg published by Akademie Verlag. The volume consists of exhibitions and plates of images Warburg compiled to illustrate lectures in the period between 1925-1929. The review focuses on two key issues raised by the publication: the light it casts on the Mnemosyne Atlas Warburg was working on at the same time, and, in particular, how it helps shape perceptions of the broader intellectual direction of Warburg's thinking in the final half decade of his life.

  16. Warburg effect or reverse Warburg effect? A review of cancer metabolism.

    Science.gov (United States)

    Xu, Xiao Dong; Shao, Shi Xiu; Jiang, Hai Ping; Cao, Yan Wei; Wang, Yong Hua; Yang, Xue Cheng; Wang, You Lin; Wang, Xin Sheng; Niu, Hai Tao

    2015-01-01

    Cancer is a major threat to human health. A considerable amount of research has focused on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor cell metabolism has been considered a hallmark of cancer. Cancer cells differ from normal cells through unlimited cell division, and show a greater need for energy for their rapid growth and duplication. Research on glycometabolism, as the key point of energy metabolism, has played a unique role. In the 1920s, Warburg found that cancer cells prefer to produce adenosine triphosphate (ATP) by glycolysis, which is a less efficient pathway compared to oxidative phosphorylation. This striking discovery, called 'the Warburg effect', has influenced and guided the study of the mechanism and treatment of tumors for generations, but its causal relationship with cancer progression is still unclear. Some studies have now shown contradicting evidence and a new hypothesis, the reverse Warburg effect, has been put forward, in which cancer cells produce most of their ATP via glycolysis, even under aerobic conditions. In this review we discuss the new points concerning the energy metabolism of a tumor, as well as the current facts and perspectives. © 2015 S. Karger GmbH, Freiburg.

  17. The Emerging Facets of Non-Cancerous Warburg Effect

    KAUST Repository

    Abdel-Haleem, Alyaa M.; Lewis, Nathan E.; Jamshidi, Neema; Mineta, Katsuhiko; Gao, Xin; Gojobori, Takashi

    2017-01-01

    The Warburg effect (WE), or aerobic glycolysis, is commonly recognized as a hallmark of cancer and has been extensively studied for potential anti-cancer therapeutics development. Beyond cancer, the WE plays an important role in many other cell

  18. Lactate as an insidious metabolite due to the Warburg effect.

    Science.gov (United States)

    Luc, Raymond; Tortorella, Stephanie M; Ververis, Katherine; Karagiannis, Tom C

    2015-04-01

    Although oncogenetics remains a critical component of cancer biology and therapeutic research, recent interest has been taken towards the non-genetic features of tumour development and progression, such as cancer metabolism. Specifically, it has been observed that tumour cells are inclined to preferentially undergo glycolysis despite presence of adequate oxygen. First reported by Otto Warburg in the 1920s, and now termed the 'Warburg effect', this aberrant metabolism has become of particular interest due to the prevalence of the fermentation phenotype in a variety of cancers studied. Consequently, this phenotype has proven to play a pivotal role in cancer proliferation. As such Warburg's observations are now being integrated within the modern paradigms of cancer and in this review we explore the role of lactate as an insidious metabolite due to the Warburg effect.

  19. Design, calibration, and performance of the MINERvA detector

    Energy Technology Data Exchange (ETDEWEB)

    Aliaga, L. [Department of Physics, College of William and Mary, Williamsburg, VA 23187 (United States); Sección Física, Departamento de Ciencias, Pontificia Universidad Católica del Perú, Apartado 1761, Lima, Perú (Peru); Bagby, L.; Baldin, B. [Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States); Baumbaugh, A. [Sección Física, Departamento de Ciencias, Pontificia Universidad Católica del Perú, Apartado 1761, Lima, Perú (Peru); Bodek, A.; Bradford, R. [University of Rochester, Rochester, NY 14610 (United States); Brooks, W.K. [Departamento de Física, Universidad Técnica Federico Santa María, Avda. España 1680, Casilla 110-V, Valparaíso (Chile); Boehnlein, D. [Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States); Boyd, S. [Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Budd, H. [University of Rochester, Rochester, NY 14610 (United States); Butkevich, A. [Institute for Nuclear Research of the Russian Academy of Sciences, 117312 Moscow (Russian Federation); Martinez Caicedo, D.A.; Castromonte, C.M. [Hampton University, Department of Physics, Hampton, VA 23668 (United States); Christy, M.E. [Department of Physics, University of Minnesota – Duluth, Duluth, MN 55812 (United States); Chvojka, J. [University of Rochester, Rochester, NY 14610 (United States); Motta, H. da [Centro Brasileiro de Pesquisas Físicas, Rua Dr. Xavier Sigaud 150, Urca, Rio de Janeiro, RJ 22290-180 (Brazil); and others

    2014-04-11

    The MINERvA experiment is designed to perform precision studies of neutrino-nucleus scattering using ν{sub μ} and ν{sup ¯}{sub μ} neutrinos incident at 1–20 GeV in the NuMI beam at Fermilab. This article presents a detailed description of the MINERvA detector and describes the ex situ and in situ techniques employed to characterize the detector and monitor its performance. The detector is composed of a finely segmented scintillator-based inner tracking region surrounded by electromagnetic and hadronic sampling calorimetry. The upstream portion of the detector includes planes of graphite, iron and lead interleaved between tracking planes to facilitate the study of nuclear effects in neutrino interactions. Observations concerning the detector response over sustained periods of running are reported. The detector design and methods of operation have relevance to future neutrino experiments in which segmented scintillator tracking is utilized.

  20. Arsenic exposure induces the Warburg effect in cultured human cells

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Fei; Severson, Paul; Pacheco, Samantha; Futscher, Bernard W.; Klimecki, Walter T., E-mail: klimecki@pharmacy.arizona.edu

    2013-08-15

    Understanding how arsenic exacts its diverse, global disease burden is hampered by a limited understanding of the particular biological pathways that are disrupted by arsenic and underlie pathogenesis. A reductionist view would predict that a small number of basic pathways are generally perturbed by arsenic, and manifest as diverse diseases. Following an initial observation that arsenite-exposed cells in culture acidify their media more rapidly than control cells, the report here shows that low level exposure to arsenite (75 ppb) is sufficient to induce aerobic glycolysis (the Warburg effect) as a generalized phenomenon in cultured human primary cells and cell lines. Expanded studies in one such cell line, the non-malignant pulmonary epithelial line, BEAS-2B, established that the arsenite-induced Warburg effect was associated with increased accumulation of intracellular and extracellular lactate, an increased rate of extracellular acidification, and inhibition by the non-metabolized glucose analog, 2-deoxy-D-glucose. Associated with the induction of aerobic glycolysis was a pathway-wide induction of glycolysis gene expression, as well as protein accumulation of an established glycolysis master-regulator, hypoxia-inducible factor 1A. Arsenite-induced alteration of energy production in human cells represents the type of fundamental perturbation that could extend to many tissue targets and diseases. - Highlights: • Chronic arsenite exposure induces aerobic glycolysis, dubbed the “Warburg effect”. • Arsenite-induced Warburg effect is a general phenomenon in cultured human cells. • HIF-1A may mediate arsenite induced Warburg effect.

  1. Arsenic exposure induces the Warburg effect in cultured human cells

    International Nuclear Information System (INIS)

    Zhao, Fei; Severson, Paul; Pacheco, Samantha; Futscher, Bernard W.; Klimecki, Walter T.

    2013-01-01

    Understanding how arsenic exacts its diverse, global disease burden is hampered by a limited understanding of the particular biological pathways that are disrupted by arsenic and underlie pathogenesis. A reductionist view would predict that a small number of basic pathways are generally perturbed by arsenic, and manifest as diverse diseases. Following an initial observation that arsenite-exposed cells in culture acidify their media more rapidly than control cells, the report here shows that low level exposure to arsenite (75 ppb) is sufficient to induce aerobic glycolysis (the Warburg effect) as a generalized phenomenon in cultured human primary cells and cell lines. Expanded studies in one such cell line, the non-malignant pulmonary epithelial line, BEAS-2B, established that the arsenite-induced Warburg effect was associated with increased accumulation of intracellular and extracellular lactate, an increased rate of extracellular acidification, and inhibition by the non-metabolized glucose analog, 2-deoxy-D-glucose. Associated with the induction of aerobic glycolysis was a pathway-wide induction of glycolysis gene expression, as well as protein accumulation of an established glycolysis master-regulator, hypoxia-inducible factor 1A. Arsenite-induced alteration of energy production in human cells represents the type of fundamental perturbation that could extend to many tissue targets and diseases. - Highlights: • Chronic arsenite exposure induces aerobic glycolysis, dubbed the “Warburg effect”. • Arsenite-induced Warburg effect is a general phenomenon in cultured human cells. • HIF-1A may mediate arsenite induced Warburg effect

  2. The Warburg effect: molecular aspects and therapeutic possibilities.

    Science.gov (United States)

    Ngo, Hanh; Tortorella, Stephanie M; Ververis, Katherine; Karagiannis, Tom C

    2015-04-01

    It has been about nine decades since the proposal of Otto Warburg on the metabolism of cancer cells. Unlike normal cells which undergo glycolysis and oxidative phosphorylation in the presence of oxygen, proliferating and cancer cells exhibit an increased uptake of glucose and increased rate of glycolysis and predominantly undergo lactic acid fermentation. Whether this phenomenon is the consequence of genetic dysregulation in cancer or is the cause of cancer still remains unknown. However, there is certainly a strong link between the genetic factors, epigenetic modulation, cancer immunosurveillance and the Warburg effect, which will be discussed in this review. Dichloroacetate and 3-bromopyruvate are among the substances that have been studied as potential cancer therapies. With our expanding knowledge of cellular metabolism, therapies targeting the Warburg effect appear very promising. This review discusses different aspects of these emerging therapies.

  3. Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

    KAUST Repository

    Demetrius, Lloyd A.; Magistretti, Pierre J.; Pellerin, Luc

    2015-01-01

    Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's disease (AD) are characterized by the following hallmarks: (a) An exponential increase with age; (b) Selective neuronal vulnerability; (c) Inverse cancer comorbidity. The present article appeals to these hallmarks to evaluate and contrast two competing models of AD: the amyloid hypothesis (a neuron-centric mechanism) and the Inverse Warburg hypothesis (a neuron-astrocytic mechanism). We show that these three hallmarks of AD conflict with the amyloid hypothesis, but are consistent with the Inverse Warburg hypothesis, a bioenergetic model which postulates that AD is the result of a cascade of three events—mitochondrial dysregulation, metabolic reprogramming (the Inverse Warburg effect), and natural selection. We also provide an explanation for the failures of the clinical trials based on amyloid immunization, and we propose a new class of therapeutic strategies consistent with the neuroenergetic selection model.

  4. Anesthesia for a child with Walker–Warburg syndrome

    Directory of Open Access Journals (Sweden)

    Emine Arzu Kose

    2014-03-01

    Full Text Available Background and objectives: Walker–Warburg Syndrome is a rare, autosomal recessive congenital muscular dystrophy manifested by central nervous system, eye malformations and possible multisystem involvement. The diagnosis is established by the presence of four criteria: congenital muscular dystrophy, type II lissencephaly, cerebellar malformation, and retinal malformation. Most of the syndromic children die in the first three years of life because of respiratory failure, pneumonia, seizures, hyperthermia and ventricular fibrillation. Case report: The anesthetic management of a two-months-old male child listed for elective ventriculo-peritoneal shunt operation was discussed. Conclusions: A careful anesthetic management is necessary due to the multisystem involvement. We reported anesthetic management of a two-months-old male child with Walker–Warburg Syndrome who was listed for elective ventriculo-peritoneal shunt operation. Keywords: Walker–Warburg Syndrome, Congenital muscular dystrophy, General anesthesia

  5. Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

    KAUST Repository

    Demetrius, Lloyd A.

    2015-01-14

    Epidemiological and biochemical studies show that the sporadic forms of Alzheimer\\'s disease (AD) are characterized by the following hallmarks: (a) An exponential increase with age; (b) Selective neuronal vulnerability; (c) Inverse cancer comorbidity. The present article appeals to these hallmarks to evaluate and contrast two competing models of AD: the amyloid hypothesis (a neuron-centric mechanism) and the Inverse Warburg hypothesis (a neuron-astrocytic mechanism). We show that these three hallmarks of AD conflict with the amyloid hypothesis, but are consistent with the Inverse Warburg hypothesis, a bioenergetic model which postulates that AD is the result of a cascade of three events—mitochondrial dysregulation, metabolic reprogramming (the Inverse Warburg effect), and natural selection. We also provide an explanation for the failures of the clinical trials based on amyloid immunization, and we propose a new class of therapeutic strategies consistent with the neuroenergetic selection model.

  6. Model Uncertainties for Valencia RPA Effect for MINERvA

    Energy Technology Data Exchange (ETDEWEB)

    Gran, Richard [Univ. of Minnesota, Duluth, MN (United States)

    2017-05-08

    This technical note describes the application of the Valencia RPA multi-nucleon effect and its uncertainty to QE reactions from the GENIE neutrino event generator. The analysis of MINERvA neutrino data in Rodrigues et al. PRL 116 071802 (2016) paper makes clear the need for an RPA suppression, especially at very low momentum and energy transfer. That published analysis does not constrain the magnitude of the effect; it only tests models with and without the effect against the data. Other MINERvA analyses need an expression of the model uncertainty in the RPA effect. A well-described uncertainty can be used for systematics for unfolding, for model errors in the analysis of non-QE samples, and as input for fitting exercises for model testing or constraining backgrounds. This prescription takes uncertainties on the parameters in the Valencia RPA model and adds a (not-as-tight) constraint from muon capture data. For MINERvA we apply it as a 2D ($q_0$,$q_3$) weight to GENIE events, in lieu of generating a full beyond-Fermi-gas quasielastic events. Because it is a weight, it can be applied to the generated and fully Geant4 simulated events used in analysis without a special GENIE sample. For some limited uses, it could be cast as a 1D $Q^2$ weight without much trouble. This procedure is a suitable starting point for NOvA and DUNE where the energy dependence is modest, but probably not adequate for T2K or MicroBooNE.

  7. Preliminary results from the MINERvA experiment

    International Nuclear Information System (INIS)

    Harris, Deborah A.

    2011-01-01

    The MINERvA experiment, operating since 2009 in the NuMI neutrino beam line at Fermilab, has collected neutrino and antineutrino scattering data on a variety of nuclear targets. The detector is designed to identify events originating in plastic scintillator, lead, carbon, iron, water, and liquid helium. The goal of the experiment is to measure inclusive and exclusive cross sections for neutrino and antineutrino with much greater precision than previous experiments. We present preliminary kinematic distributions for charged current quasi-elastic scattering and other processes.

  8. Involvement of the Warburg effect in non-tumor diseases processes.

    Science.gov (United States)

    Chen, Zhe; Liu, Meiqing; Li, Lanfang; Chen, Linxi

    2018-04-01

    Warburg effect, as an energy shift from mitochondrial oxidative phosphorylation to aerobic glycolysis, is extensively found in various cancers. Interestingly, increasing researchers show that Warburg effect plays a crucial role in non-tumor diseases. For instance, inhibition of Warburg effect can alleviate pulmonary vascular remodeling in the process of pulmonary hypertension (PH). Interference of Warburg effect improves mitochondrial function and cardiac function in the process of cardiac hypertrophy and heart failure. Additionally, the Warburg effect induces vascular smooth muscle cell proliferation and contributes to atherosclerosis. Warburg effect may also involve in axonal damage and neuronal death, which are related with multiple sclerosis. Furthermore, Warburg effect significantly promotes cell proliferation and cyst expansion in polycystic kidney disease (PKD). Besides, Warburg effect relieves amyloid β-mediated cell death in Alzheimer's disease. And Warburg effect also improves the mycobacterium tuberculosis infection. Finally, we also introduce some glycolytic agonists. This review focuses on the newest researches about the role of Warburg effect in non-tumor diseases, including PH, tuberculosis, idiopathic pulmonary fibrosis (IPF), failing heart, cardiac hypertrophy, atherosclerosis, Alzheimer's diseases, multiple sclerosis, and PKD. Obviously, Warburg effect may be a potential therapeutic target for those non-tumor diseases. © 2017 Wiley Periodicals, Inc.

  9. Generalized Warburg impedance on realistic self-affine fractals ...

    Indian Academy of Sciences (India)

    Administrator

    Generalized Warburg impedance on realistic self-affine fractals: Comparative study of statistically corrugated and isotropic roughness. RAJESH KUMAR and RAMA KANT. Journal of Chemical Sciences, Vol. 121, No. 5, September 2009, pp. 579–588. 1. ( ) c. L. R ω on page 582, column 2, para 2, after eq (8) should read as ...

  10. MINERVA - a multi-modal radiation treatment planning system

    Energy Technology Data Exchange (ETDEWEB)

    Wemple, C.A. E-mail: cew@enel.gov; Wessol, D.E.; Nigg, D.W.; Cogliati, J.J.; Milvich, M.L.; Frederickson, C.; Perkins, M.; Harkin, G.J

    2004-11-01

    Researchers at the Idaho National Engineering and Environmental Laboratory and Montana State University have undertaken development of MINERVA, a patient-centric, multi-modal, radiation treatment planning system. This system can be used for planning and analyzing several radiotherapy modalities, either singly or combined, using common modality independent image and geometry construction and dose reporting and guiding. It employs an integrated, lightweight plugin architecture to accommodate multi-modal treatment planning using standard interface components. The MINERVA design also facilitates the future integration of improved planning technologies. The code is being developed with the Java Virtual Machine for interoperability. A full computation path has been established for molecular targeted radiotherapy treatment planning, with the associated transport plugin developed by researchers at the Lawrence Livermore National Laboratory. Development of the neutron transport plugin module is proceeding rapidly, with completion expected later this year. Future development efforts will include development of deformable registration methods, improved segmentation methods for patient model definition, and three-dimensional visualization of the patient images, geometry, and dose data. Transport and source plugins will be created for additional treatment modalities, including brachytherapy, external beam proton radiotherapy, and the EGSnrc/BEAMnrc codes for external beam photon and electron radiotherapy.

  11. Extruded plastic scintillator for MINERvA

    International Nuclear Information System (INIS)

    Pla-Dalmau, Anna; Bross, Alan D.; FermilabRykalin, Victor V.; Wood, Brian M.; NICADD, DeKalb

    2005-01-01

    An extrusion line has recently been installed at Fermilab in collaboration with NICADD (Northern Illinois Center for Accelerator and Detector Development). This new facility will serve to further develop and improve extruded plastic scintillator. Since polystyrene is widely used in the consumer industry, the logical path was to investigate the extrusion of commercial-grade polystyrene pellets with dopants to yield high quality plastic scintillator. The D0 and MINOS experiments are already using extruded scintillator strips in their detectors. A new experiment at Fermilab is pursuing the use of extruded plastic scintillator. A new plastic scintillator strip is being tested and its properties characterized. The initial results are presented here

  12. The Emerging Facets of Non-Cancerous Warburg Effect

    KAUST Repository

    Abdel-Haleem, Alyaa M.

    2017-10-23

    The Warburg effect (WE), or aerobic glycolysis, is commonly recognized as a hallmark of cancer and has been extensively studied for potential anti-cancer therapeutics development. Beyond cancer, the WE plays an important role in many other cell types involved in immunity, angiogenesis, pluripotency, and infection by pathogens (e.g., malaria). Here, we review the WE in non-cancerous context as a

  13. VME Data Acquisition Modules for MINERvA Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Baldin, B.; /fermilab

    2010-01-01

    This document describes two VME modules developed for MINERvA experiment at Fermilab. The Chain ReadOut Controller (CROC) module has four serial data channels and can interface with up to 48 front-ends using standard CAT5e networking cable. The data transmission rate of each channel is 160 Mbit/s. The maximum data transmission rate via VME bus is {approx}18 MB/s. The Chain Readout Interface Module (CRIM) is designed to provide various interface functions for the CROC module. It is compatible with MINOS MTM timing module and can be used to distribute timing signals to four CROC modules. The CRIM module also has a data port compatible with the CROC serial data interface. The data port can be used for diagnostic purpose and can generate triggers from front-end events. The CRIM module is a standard D08(O) interrupter module.

  14. Theoretical interpretation of Warburg's impedance in unsupported electrolytic cells.

    Science.gov (United States)

    Barbero, G

    2017-12-13

    We discuss the origin of Warburg's impedance in unsupported electrolytic cells containing only one group of positive and one group of negative ions. Our analysis is based on the Poisson-Nernst-Planck model, where the generation-recombination phenomenon is neglected. We show that to observe Warburg-like impedance the diffusion coefficient of the positive ions has to differ from that of the negative ones, and furthermore the electrodes have to be not blocking. We assume that the non-blocking properties of the electrodes can be described by means of an Ohmic model, where the charge exchange between the cell and the external circuit is described by means of an electrode conductivity. For simplicity we consider a symmetric cell. However, our analysis can be easily generalized to more complicated situations, where the cell is not symmetric and the charge exchange is described by the Chang-Jaffe model, or by a linearized version of the Butler-Volmer equation. Our analysis allows justification of the expression for Warburg's impedance proposed previously by several groups, based on wrong assumptions.

  15. Project Minerva: A low cost manned Mars mission based on indigenous propellant production

    Science.gov (United States)

    Beder, David; Bryan, Richard; Bui, Tuyen; Caviezel, Kelly; Cinnamon, Mark; Daggert, Todd; Folkers, Mike; Fornia, Mark; Hanks, Natasha; Hamilton, Steve

    1992-01-01

    Project Minerva is a low-cost manned Mars mission designed to deliver a crew of four to the Martian surface using only two sets of two launches from the Kennedy Space Center. Key concepts which make this mission realizable are the use of near-term technologies and in-situ propellant production, following the scenario originally proposed by R. Zubrin. The first set of launches delivers two unmanned payloads into low Earth orbit (LEO): the first payload consists of an Earth Return Vehicle (ERV), a propellant production plant, and a set of robotic vehicles; the second payload consists of the trans-Mars injection (TMI) upper stage. In LEO, the two payloads are docked and the configuration is injected into a Mars transfer orbit. The landing on Mars is performed with the aid of multiple aerobraking maneuvers. On the Martian surface, the propellant production plant uses a Sabatier/electrolysis type process to combine nine tons of hydrogen with carbon dioxide from the Martian atmosphere to produce over a hundred tons of liquid oxygen and liquid methane, which are later used as the propellants for the rover expeditions and the manned return journey of the ERV. The systems necessary for the flights to and from Mars, as well as those needed for the stay on Mars, are discussed. These systems include the transfer vehicle design, life support, guidance and communications, rovers and telepresence, power generation, and propellant manufacturing. Also included are the orbital mechanics, the scientific goals, and the estimated mission costs.

  16. Minerva: using a software program to improve resident performance during independent call

    Science.gov (United States)

    Itri, Jason N.; Redfern, Regina O.; Cook, Tessa; Scanlon, Mary H.

    2010-03-01

    We have developed an application called Minerva that allows tracking of resident discrepancy rates and missed cases. Minerva mines the radiology information system (RIS) for preliminary interpretations provided by residents during independent call and copies both the preliminary and final interpretations to a database. Both versions are displayed for direct comparison by Minerva and classified as 'in agreement', 'minor discrepancy' or 'major discrepancy' by the resident program director. Minerva compiles statistics comparing minor, major and total discrepancy rates for individual residents relative to the overall group. Discrepant cases are categorized according to date, modality and body part and reviewed for trends in missed cases. The rate of minor, major and total discrepancies for residents on-call at our institution was similar to rates previously published, including a 2.4% major discrepancy rate for second year radiology residents in the DePICTORS study and a 2.6% major discrepancy rate for resident at a community hospital. Trend analysis of missed cases was used to generate a topic-specific resident missed case conference on acromioclavicular (AC) joint separation injuries, which resulted in a 75% decrease in the number of missed cases related to AC separation subsequent to the conference. Using a software program to track of minor and major discrepancy rates for residents taking independent call using modified RadPeer scoring guidelines provides a competency-based metric to determine resident performance. Topic-specific conferences using the cases identified by Minerva can result in a decrease in missed cases.

  17. Difficulties with Prenatal Diagnosis of the Walker-Warburg Syndrome

    International Nuclear Information System (INIS)

    Low, A.S.C.; Lee, S.L.; Tan, A.S.A.; Chan, D.K.L.; Chan, L.L.

    2005-01-01

    We describe a postnatally diagnosed case of Walker-Warburg syndrome - a form of congenital muscular dystrophy with lissencephaly and eye abnormalities. We reviewed the literature to highlight its clinico-radiological diagnostic features and discuss the difficulties encountered with prenatal diagnosis, especially in cases with no positive family history. An increased awareness of this rare but lethal condition, and a high index of suspicion during routine antenatal ultrasound, could prompt further advanced fetal ultrasonography and magnetic resonance imaging, and aid in timely prenatal diagnosis, management, and counseling. Brain/brainstem, congenital, magnetic resonance imaging, obstetrics, pediatrics, ultrasound

  18. Difficulties with Prenatal Diagnosis of the Walker-Warburg Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Low, A.S.C.; Lee, S.L.; Tan, A.S.A.; Chan, D.K.L.; Chan, L.L. [Singapore General Hospital (Singapore). Depts. of Diagnostic Radiology, Obstetrics and Gynecology and Neonatology

    2005-10-01

    We describe a postnatally diagnosed case of Walker-Warburg syndrome - a form of congenital muscular dystrophy with lissencephaly and eye abnormalities. We reviewed the literature to highlight its clinico-radiological diagnostic features and discuss the difficulties encountered with prenatal diagnosis, especially in cases with no positive family history. An increased awareness of this rare but lethal condition, and a high index of suspicion during routine antenatal ultrasound, could prompt further advanced fetal ultrasonography and magnetic resonance imaging, and aid in timely prenatal diagnosis, management, and counseling. Brain/brainstem, congenital, magnetic resonance imaging, obstetrics, pediatrics, ultrasound.

  19. Understanding Super-Earths with MINERVA-Australis at USQ's Mount Kent Observatory

    Science.gov (United States)

    Wittenmyer, Robert; Horner, Jonathan; Kane, Stephen; Plavchan, Peter; Ciardi, David; Eastman, Jason; Johnson, John Asher; Wright, Jason; McCrady, Nate; MINERVA Collaboration

    2018-01-01

    Super Earths, planets between 5-10 Earth masses, are the most common types of planets known, yet are completely absent from our Solar system. As a result, their detailed properties, compositions, and formation mechanisms are poorly understood. NASA's Transiting Exoplanet Survey Satellite (TESS) will identify hundreds of Super-Earths orbiting bright stars, for the first time allowing in-depth characterisation of these planets. At the University of Southern Queensland, we are host to the MINERVA-Australis project, dedicated wholly to the follow-up characterisation and mass measurement of TESS planets. We give an update on the status of MINERVA-Australis and our expected performance. We also present results from the fully operational Northern MINERVA array, with the primary mission of discovering rocky planets orbiting 80 nearby bright stars.

  20. Arachne - A web-based event viewer for MINERvA

    International Nuclear Information System (INIS)

    Tagg, N.; Brangham, J.; Chvojka, J.; Clairemont, M.; Day, M.; Eberly, B.; Felix, J.; Fields, L.; Gago, A.M.; Gran, R.; Harris, D.A.

    2011-01-01

    Neutrino interaction events in the MINERvA detector are visually represented with a web-based tool called Arachne. Data are retrieved from a central server via AJAX, and client-side JavaScript draws images into the user's browser window using the draft HTML 5 standard. These technologies allow neutrino interactions to be viewed by anyone with a web browser, allowing for easy hand-scanning of particle interactions. Arachne has been used in MINERvA to evaluate neutrino data in a prototype detector, to tune reconstruction algorithms, and for public outreach and education.

  1. Arachne - A web-based event viewer for MINERvA

    Energy Technology Data Exchange (ETDEWEB)

    Tagg, N.; /Otterbein Coll.; Brangham, J.; /Otterbein Coll.; Chvojka, J.; /Rochester U.; Clairemont, M.; /Otterbein Coll.; Day, M.; /Rochester U.; Eberly, B.; /Pittsburgh U.; Felix, J.; /Guanajuato U.; Fields, L.; /Northwestern U.; Gago, A.M.; /Lima, Pont. U. Catolica; Gran, R.; /Maryland U.; Harris, D.A.; /Fermilab /William-Mary Coll.

    2011-11-01

    Neutrino interaction events in the MINERvA detector are visually represented with a web-based tool called Arachne. Data are retrieved from a central server via AJAX, and client-side JavaScript draws images into the user's browser window using the draft HTML 5 standard. These technologies allow neutrino interactions to be viewed by anyone with a web browser, allowing for easy hand-scanning of particle interactions. Arachne has been used in MINERvA to evaluate neutrino data in a prototype detector, to tune reconstruction algorithms, and for public outreach and education.

  2. Metabolic changes in cancer: beyond the Warburg effect

    Institute of Scientific and Technical Information of China (English)

    Weihua Wu; Shimin Zhao

    2013-01-01

    Altered metabolism is one of the hallmarks of cancer cells.The best-known metabolic abnormality in cancer cells is the Warburg effect,which demonstrates an increased glycolysis even in the presence of oxygen.However,tumor-related metabolic abnormalities are not limited to altered balance between glucose fermentation and oxidative phosphorylation.Key tumor genes such as p53 and c-myc are found to be master regulators of metabolism.Metabolic enzymes such as succinate dehydrogenase,fumarate hydratase,pyruvate kinase,and isocitrate dehydrogenase mutations or expressing level alterations are all linked to tumorigenesis.In this review,we introduce some of the cancer-associated metabolic disorders and current understanding of their molecular tumorigenic mechanisms.

  3. NuMI Flux Predictions for NOvA and MINERvA

    Science.gov (United States)

    Aliaga Soplin, Leonidas; Nova Collaboration; Minerva Collaboration

    2017-01-01

    The determination of the neutrino flux in any conventional neutrino beam presents a challenge for the current and future short and long baseline neutrino experiments. The uncertainties associated with the production and attenuation of the hadrons in the beamline materials along with those associated with the beam optics have a big effect in the knowledge of the flux. For experiments like MINERvA and NOvA, understanding the flux is crucial since it enters directly into every neutrino-nucleus cross-section measurement. The majority of this work involves predicting the neutrino flux using dedicated hadron production measurements from hadron-nucleus collisions. The predictions at the MINERvA and NOvA near detectors are presented as well as the results of incorporating in-situ MINERvA data that can provide additional constraints. These results have been fully implemented in MINERvA and they are currently use for its cross-section analysis. The implementation for NoVA is underway. The procedure and conclusions of this work will have a big impact on future hadron production experiments and on determining the flux for the upcoming DUNE experiment.

  4. MINERvA neutrino detector response measured with test beam data

    International Nuclear Information System (INIS)

    Aliaga, L.; Altinok, O.; Araujo Del Castillo, C.; Bagby, L.; Bellantoni, L.; Bergan, W.F.; Bodek, A.; Bradford, R.; Bravar, A.; Budd, H.; Butkevich, A.; Martinez Caicedo, D.A.; Carneiro, M.F.; Christy, M.E.; Chvojka, J.; Motta, H. da; Devan, J.

    2015-01-01

    The MINERvA collaboration operated a scaled-down replica of thesolid scintillator tracking and sampling calorimeter regions of the MINERvA detector in a hadron test beam at the Fermilab Test Beam Facility. This paper reports measurements with samples of protons, pions, and electrons from 0.35 to 2.0 GeV/c momentum. The calorimetric response to protons, pions, and electrons is obtained from these data. A measurement of the parameter in Birks' law and an estimate of the tracking efficiency are extracted from the proton sample. Overall the data are well described by a Geant4-based Monte Carlo simulation of the detector and particle interactions with agreements better than 4% for the calorimetric response, though some features of the data are not precisely modeled. These measurements are used to tune the MINERvA detector simulation and evaluate systematic uncertainties in support of the MINERvA neutrino cross-section measurement program

  5. MINERvA neutrino detector response measured with test beam data

    Energy Technology Data Exchange (ETDEWEB)

    Aliaga, L. [Department of Physics, College of William & Mary, Williamsburg, VA 23187 (United States); Altinok, O. [Physics Department, Tufts University, Medford, MA 02155 (United States); Araujo Del Castillo, C. [Sección Física, Departamento de Ciencias, Pontificia Universidad Católica del Perú, Apartado 1761, Lima (Peru); Bagby, L.; Bellantoni, L. [Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States); Bergan, W.F. [Department of Physics, College of William & Mary, Williamsburg, VA 23187 (United States); Bodek, A.; Bradford, R. [University of Rochester, Rochester, New York 14627 (United States); Bravar, A. [University of Geneva, 1211 Geneva 4 (Switzerland); Budd, H. [University of Rochester, Rochester, New York 14627 (United States); Butkevich, A. [Institute for Nuclear Research of the Russian Academy of Sciences, 117312 Moscow (Russian Federation); Martinez Caicedo, D.A. [Centro Brasileiro de Pesquisas Físicas, Rua Dr. Xavier Sigaud 150, Urca, Rio de Janeiro, Rio de Janeiro 22290-180 (Brazil); Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States); Carneiro, M.F. [Centro Brasileiro de Pesquisas Físicas, Rua Dr. Xavier Sigaud 150, Urca, Rio de Janeiro, Rio de Janeiro 22290-180 (Brazil); Christy, M.E. [Hampton University, Department of Physics, Hampton, VA 23668 (United States); Chvojka, J. [University of Rochester, Rochester, New York 14627 (United States); Motta, H. da [Centro Brasileiro de Pesquisas Físicas, Rua Dr. Xavier Sigaud 150, Urca, Rio de Janeiro, Rio de Janeiro 22290-180 (Brazil); Devan, J. [Department of Physics, College of William & Mary, Williamsburg, VA 23187 (United States); and others

    2015-07-21

    The MINERvA collaboration operated a scaled-down replica of thesolid scintillator tracking and sampling calorimeter regions of the MINERvA detector in a hadron test beam at the Fermilab Test Beam Facility. This paper reports measurements with samples of protons, pions, and electrons from 0.35 to 2.0 GeV/c momentum. The calorimetric response to protons, pions, and electrons is obtained from these data. A measurement of the parameter in Birks' law and an estimate of the tracking efficiency are extracted from the proton sample. Overall the data are well described by a Geant4-based Monte Carlo simulation of the detector and particle interactions with agreements better than 4% for the calorimetric response, though some features of the data are not precisely modeled. These measurements are used to tune the MINERvA detector simulation and evaluate systematic uncertainties in support of the MINERvA neutrino cross-section measurement program.

  6. Lactic Acidosis in Prostate Cancer: Consider the Warburg Effect

    Directory of Open Access Journals (Sweden)

    Johannes C. van der Mijn

    2017-11-01

    Full Text Available Lactic acidosis is a commonly observed clinical condition that is associated with a poor prognosis, especially in malignancies. We describe a case of an 81-year-old patient who presented with symptoms of tachypnea and general discomfort. Arterial blood gas analysis showed a high anion gap acidosis with a lactate level of 9.5 mmol/L with respiratory compensation. CT scanning showed no signs of pulmonary embolism or other causes of impaired tissue oxygenation. Despite treatment with sodium bicarbonate, the patient developed an adrenalin-resistant cardiac arrest, most likely caused by the acidosis. Autopsy revealed Gleason score 5 + 5 metastatic prostate cancer as the most probable cause of the lactic acidosis. Next-generation sequencing indicated a nonsense mutation in the TP53 gene (887delA and an activating mutation in the PIK3CA gene (1634A>G as candidate molecular drivers. This case demonstrates the prevalence and clinical relevance of metabolic reprogramming, frequently referred to as “the Warburg effect,” in patients with prostate cancer.

  7. Measurement of partonic nuclear effects in deep-inelastic neutrino scattering using MINERvA

    Science.gov (United States)

    Mousseau, J.; Wospakrik, M.; Aliaga, L.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Budd, H.; Cai, T.; Carneiro, M. F.; Christy, M. E.; Chvojka, J.; da Motta, H.; Devan, J.; Dytman, S. A.; Díaz, G. A.; Eberly, B.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Gallagher, H.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Hurtado, K.; Kiveni, M.; Kleykamp, J.; Kordosky, M.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Marshall, C. M.; Martinez Caicedo, D. A.; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman; Osta, J.; Paolone, V.; Park, J.; Patrick, C. E.; Perdue, G. N.; Rakotondravohitra, L.; Ramirez, M. A.; Ransome, R. D.; Ray, H.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schellman, H.; Schmitz, D. W.; Solano Salinas, C. J.; Tagg, N.; Tice, B. G.; Valencia, E.; Walton, T.; Wolcott, J.; Zavala, G.; Zhang, D.; Minerν A Collaboration

    2016-04-01

    The MINERvA Collaboration reports a novel study of neutrino-nucleus charged-current deep inelastic scattering (DIS) using the same neutrino beam incident on targets of polystyrene, graphite, iron, and lead. Results are presented as ratios of C, Fe, and Pb to CH. The ratios of total DIS cross sections as a function of neutrino energy and flux-integrated differential cross sections as a function of the Bjorken scaling variable x are presented in the neutrino-energy range of 5-50 GeV. Based on the predictions of charged-lepton scattering ratios, good agreement is found between the data and prediction at medium x and low neutrino energy. However, the ratios appear to be below predictions in the vicinity of the nuclear shadowing region, x <0.1 . This apparent deficit, reflected in the DIS cross-section ratio at high Eν, is consistent with previous MINERvA observations [B. Tice et al. (MINERvA Collaboration), Phys. Rev. Lett. 112, 231801 (2014).] and with the predicted onset of nuclear shadowing with the axial-vector current in neutrino scattering.

  8. MINERVA: A multi-modality plug-in-based radiation therapy treatment planning system

    International Nuclear Information System (INIS)

    Wemple, C. A.; Wessol, D. E.; Nigg, D. W.; Cogliati, J. J.; Milvich, M.; Fredrickson, C. M.; Perkins, M.; Harkin, G. J.; Hartmann-Siantar, C. L.; Lehmann, J.; Flickinger, T.; Pletcher, D.; Yuan, A.; DeNardo, G. L.

    2005-01-01

    Researchers at the INEEL, MSU, LLNL and UCD have undertaken development of MINERVA, a patient-centric, multi-modal, radiation treatment planning system, which can be used for planning and analysing several radiotherapy modalities, either singly or combined, using common treatment planning tools. It employs an integrated, lightweight plug-in architecture to accommodate multi-modal treatment planning using standard interface components. The design also facilitates the future integration of improved planning technologies. The code is being developed with the Java programming language for inter-operability. The MINERVA design includes the image processing, model definition and data analysis modules with a central module to coordinate communication and data transfer. Dose calculation is performed by source and transport plug-in modules, which communicate either directly through the database or through MINERVA's openly published, extensible markup language (XML)-based application programmer's interface (API). All internal data are managed by a database management system and can be exported to other applications or new installations through the API data formats. A full computation path has been established for molecular-targeted radiotherapy treatment planning, with additional treatment modalities presently under development. (authors)

  9. Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K.

    Science.gov (United States)

    Courtnay, Rupert; Ngo, Darleen C; Malik, Neha; Ververis, Katherine; Tortorella, Stephanie M; Karagiannis, Tom C

    2015-04-01

    Cancer cells have been shown to have altered metabolism when compared to normal non-malignant cells. The Warburg effect describes a phenomenon in which cancer cells preferentially metabolize glucose by glycolysis, producing lactate as an end product, despite being the presence of oxygen. The phenomenon was first described by Otto Warburg in the 1920s, and has resurfaced as a controversial theory, with both supportive and opposing arguments. The biochemical aspects of the Warburg effect outline a strong explanation for the cause of cancer cell proliferation, by providing the biological requirements for a cell to grow. Studies have shown that pathways such as phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) as well as hypoxia inducible factor-1 (HIF-1) are central regulators of glycolysis, cancer metabolism and cancer cell proliferation. Studies have shown that PI3K signaling pathways have a role in many cellular processes such as metabolism, inflammation, cell survival, motility and cancer progression. Herein, the cellular aspects of the PI3K pathway are described, as well as the influence HIF has on cancer cell metabolism. HIF-1 activation has been related to angiogenesis, erythropoiesis and modulation of key enzymes involved in aerobic glycolysis, thereby modulating key processes required for the Warburg effect. In this review we discuss the molecular aspects of the Warburg effect with a particular emphasis on the role of the HIF-1 and the PI3K pathway.

  10. Tests of the Hardware and Software for the Reconstruction of Trajectories in the Experiment MINERvA

    International Nuclear Information System (INIS)

    Palomino Gallo, Jose Luis

    2009-01-01

    MINERvA experiment has a highly segmented and high precision neutrino detector able to record events with high statistic (over 13 millions in a four year run). MINERvA uses FERMILAB NuMI beamline. The detector will allow a detailed study of neutrino-nucleon interactions. Moreover, the detector has a target with different materials allowing, for the first time, the study of nuclear effects in neutrino interactions. We present here the work done with the MINERvA reconstruction group that has resulted in: (a) development of new codes to be added to the RecPack package so it can be adapted to the MINERvA detector structure; (b) finding optimum values for two of the MegaTracker reconstruction package variables: PEcut = 4 (minimum number of photo electrons for a signal to be accepted) and Chi2Cut = 200 (maximum value of χ 2 for a track to be accepted); (c) testing of the multi anode photomultiplier tubes used at MINERvA in order to determine the correlation between different channels and for checking the device's dark counts.

  11. Tests of the Hardware and Software for the Reconstruction of Trajectories in the Experiment MINERvA

    Energy Technology Data Exchange (ETDEWEB)

    Palomino Gallo, Jose Luis; /Rio de Janeiro, CBPF

    2009-05-01

    MINERvA experiment has a highly segmented and high precision neutrino detector able to record events with high statistic (over 13 millions in a four year run). MINERvA uses FERMILAB NuMI beamline. The detector will allow a detailed study of neutrino-nucleon interactions. Moreover, the detector has a target with different materials allowing, for the first time, the study of nuclear effects in neutrino interactions. We present here the work done with the MINERvA reconstruction group that has resulted in: (a) development of new codes to be added to the RecPack package so it can be adapted to the MINERvA detector structure; (b) finding optimum values for two of the MegaTracker reconstruction package variables: PEcut = 4 (minimum number of photo electrons for a signal to be accepted) and Chi2Cut = 200 (maximum value of {chi}{sup 2} for a track to be accepted); (c) testing of the multi anode photomultiplier tubes used at MINERvA in order to determine the correlation between different channels and for checking the device's dark counts.

  12. On the reverse. Some notes on photographic images from the Warburg Institute Photographic Collection

    Directory of Open Access Journals (Sweden)

    Katia Mazzucco

    2012-10-01

    Full Text Available How can the visual and textual data about an image – the image of a work of art – on recto and verso of a picture be interpreted? An analogical-art-documentary photograph represents a palimpsest to be considered layer by layer. The examples discussed in this article, which refer to both Aby Warburg himself and the first nucleus of the Warburg Institute Photographic Collection, contribute to effectively outline elements of the debate around the question of the photographic reproduction of the work of art as well as of the position of photography in relation to the perception of the work of art.

  13. The Warburg/Arnheim effect: Linking cultural/social and perceptual psychology of art

    Directory of Open Access Journals (Sweden)

    Ladislav Kesner

    2015-01-01

    Full Text Available Aby Warburg and Rudolf Arnheim represent two, mutually complementary, ways of productive interfacing between art history/culture history on the one hand and psychology on the other. It is suggested that neither Warburg´s nor Arnheim´s ideas could have come to form a sustainable theory without taking into account the perspective and focus that preoccupied the other. The article points to possible ways of bridging the gap between the kind of visual cultural and social psychology pursued by Warburg and the perceptual psychology that concerned Arnheim. It is argued that, far from being a matter of just historiographic interest, the attempt to make such connections touches on some key issues and concepts of art theory and its relationship to sciences of the mind and brain today. A conceptual framework is presented in which the approaches of Warburg and Arnheim can be meaningfully integrated. Both thinkers were much preoccupied by the problem of expression. The final section establishes some connections between their respective theories of expression and shows how these theories can be productively extended to address current research on the affective and the empathic response to visual art.

  14. Introduction to the molecular basis of cancer metabolism and the Warburg effect.

    Science.gov (United States)

    Ngo, Darleen C; Ververis, Katherine; Tortorella, Stephanie M; Karagiannis, Tom C

    2015-04-01

    In differentiated normal cells, the conventional route of glucose metabolism involves glycolysis, followed by the citric acid cycle and electron transport chain to generate usable energy in the form of adenosine triphosphate (ATP). This occurs in the presence of oxygen. In hypoxic conditions, normal cells undergo anaerobic glycolysis to yield significantly less energy producing lactate as a product. As first highlighted in the 1920s by Otto Warburg, the metabolism exhibited by tumor cells involves an increased rate of aerobic glycolysis, known as the Warburg effect. In aerobic glycolysis, pyruvate molecules yielded from glycolysis are converted into fewer molecules of ATP even in the presence of oxygen. Evidence indicates that the reasons as to why tumor cells undergo aerobic glycolysis include: (1) the shift in priority to accumulate biomass rather than energy production, (2) the evasion of apoptosis as fewer reactive oxygen species are released by the mitochondria and (3) the production of lactate to further fuel growth of tumors. In this mini-review we discuss emerging molecular aspects of cancer metabolism and the Warburg effect. Aspects of the Warburg effect are analyzed in the context of the established hallmarks of cancer including the role of oncogenes and tumor suppressor genes.

  15. Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome

    DEFF Research Database (Denmark)

    Aligianis, Irene A; Johnson, Colin A; Gissen, Paul

    2005-01-01

    Warburg Micro syndrome (WARBM1) is a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system and by microgenitalia. We identified homozygous inactivating mutations in RAB3GAP, encoding RAB3 GTPase activating protein, a key regulator...

  16. Neutrino-Electron Scattering in MINERvA for Constraining the NuMI Neutrino Flux

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jaewon [Univ. of Rochester, NY (United States)

    2013-01-01

    Neutrino-electron elastic scattering is used as a reference process to constrain the neutrino flux at the Main Injector (NuMI) beam observed by the MINERvA experiment. Prediction of the neutrino flux at accelerator experiments from other methods has a large uncertainty, and this uncertainty degrades measurements of neutrino oscillations and neutrino cross-sections. Neutrino-electron elastic scattering is a rare process, but its cross-section is precisely known. With a sample corresponding to $3.5\\times10^{20}$ protons on target in the NuMI low-energy neutrino beam, a sample of $120$ $\

  17. ‘”Cannon fodder for respectable question marks”: Fritz Saxl and the history of the Warburg Library’. Review of: Dorothea McEwan, Fritz Saxl – Eine Biografie: Aby Warburgs Bibliothekar und Erster Direktor des Londoner Warburg Institutes, Wien, Köln, Weimar: Böhlau Verlag, 2012

    Directory of Open Access Journals (Sweden)

    Mark A. Russell

    2013-12-01

    Full Text Available As the first Archivist of The Warburg Institute, University of London, from 1993 until her retirement in 2006, Dorothea McEwan compiled the database of the Aby Warburg Correspondence. McEwan has published and lectured widely on Warburg and Fritz Saxl. The present book is preceded by two previous volumes treating the Warburg-Saxl correspondence: Das Ausreiten der Ecken, Hamburg: Dölling und Galitz, 1998; and Wanderstrassen der Kultur, München und Hamburg: Dölling und Galitz, 2004. Based largely on Fritz Saxl’s correspondence in his various capacities as Aby Warburg’s principal aid and successor, this recounting of the Austrian scholar’s life and work is presented as a narration of the events of his professional career, and not as an intellectual biography per se. Saxl is situated within a history of the Warburg Library, is pictured as devoted to Warburg and his work, and is shown to have been critical to the functioning and survival of the Library in its various forms. As such, the book suggests that Saxl’s greatest achievement was his administrative and organizational contribution to what became the Warburg Institute. Surveying and integrating a large body of material, the author provides the necessary outlines of a career and corpus of scholarship worthy of further exploration.

  18. Electron Neutrino Charged-Current Quasielastic Scattering in the MINERvA Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Wolcott, Jeremy [Rochester U.

    2015-10-28

    The electron-neutrino charged-current quasielastic (CCQE) cross section on nuclei is an important input parameter to appearance-type neutrino oscillation experiments. Current experiments typically work from the muon neutrino cross section and apply corrections from theoretical arguments to obtain a prediction for the electron neutrino cross section, but to date there has been no experimental verification of the estimates for this channel at an energy scale appropriate to such experiments. We present the first measurement of an exclusive reaction in few-GeV electron neutrino interactions, namely, the cross section for a CCQE-like process, made using the MINERvA detector. The result is given as differential cross-sections vs. the electron energy, electron angle, and square of the four-momentum transferred to the nucleus, $Q^2$. We also compute the ratio to a muon neutrino cross-section in $Q^2$ from MINERvA. We find satisfactory agreement between this measurement and the predictions of the GENIE generator.

  19. Warburg effect increases steady-state ROS condition in cancer cells through decreasing their antioxidant capacities (anticancer effects of 3-bromopyruvate through antagonizing Warburg effect).

    Science.gov (United States)

    El Sayed, Salah Mohamed; Mahmoud, Ahmed Alamir; El Sawy, Samer Ahmed; Abdelaal, Esam Abdelrahim; Fouad, Amira Murad; Yousif, Reda Salah; Hashim, Marwa Shaban; Hemdan, Shima Badawy; Kadry, Zainab Mahmoud; Abdelmoaty, Mohamed Ahmed; Gabr, Adel Gomaa; Omran, Faten M; Nabo, Manal Mohamed Helmy; Ahmed, Nagwa Sayed

    2013-11-01

    Cancer cells undergo an increased steady-state ROS condition compared to normal cells. Among the major metabolic differences between cancer cells and normal cells is the dependence of cancer cells on glycolysis as a major source of energy even in the presence of oxygen (Warburg effect). In Warburg effect, glucose is catabolized to lactate that is extruded through monocarboxylate transporters to the microenvironment of cancer cells, while in normal cells, glucose is metabolized into pyruvate that is not extruded. Pyruvate is a potent antioxidant, while lactate has no antioxidant effect. Pyruvate in normal cells may be further metabolized to acetyl CoA and then through Krebs cycle with production of antioxidant intermediates e.g. citrate, malate and oxaloacetate together with the reducing equivalents (NADH.H+). Through activity of mitochondrial transhydrogenase, NADH.H+ replenishes NADPH.H+, coenzyme of glutathione reductase which replenishes reduced form of glutathione (potent antioxidant). This enhances antioxidant capacities of normal cells, while cancer cells exhibiting Warburg effect may be deprived of all that antioxidant capabilities due to loss of extruded lactate (substrate for Krebs cycle). Although intrinsic oxidative stress in cancer cells is high, it may be prevented from reaching progressively increasing levels that are cytotoxic to cancer cells. This may be due to some antioxidant effects exerted by hexokinase II (HK II) and NADPH.H+ produced through HMP shunt. Glycolytic phenotype in cancer cells maintains a high non-toxic oxidative stress in cancer cells and may be responsible for their malignant behavior. Through HK II, glycolysis fuels the energetic arm of malignancy, the mitotic arm of malignancy (DNA synthesis through HMP shunt pathway) and the metastatic arm of malignancy (hyaluronan synthesis through uronic acid pathway) in addition to the role of phosphohexose isomerase (autocrine motility factor). All those critical three arms start with the

  20. MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.

    Science.gov (United States)

    Zhu, Weimin; Huang, Yijiao; Pan, Qi; Xiang, Pei; Xie, Nanlan; Yu, Hao

    2017-03-01

    Warburg effect is a hallmark of cancer cells. Accumulating evidence suggests that microRNAs (miRs) could regulate such metabolic reprograming. Aberrant expression of miR-98 has been observed in many types of cancers. However, its functions and significance in colon cancer remain largely elusive. To investigate miR-98 expression and the biological functions in colon cancer progression. miR-98 expression levels were determined by quantitative RT-PCR in 215 cases of colon cancer samples. miR-98 mimic or inhibitor was used to test the biological functions in SW480 and HCT116 cells, followed by cell proliferation assay, lactate production, glucose uptake, and cellular ATP levels assay and extracellular acidification rates measurement. Western blot and luciferase assay were used to identify the target of miR-98. miR-98 was significantly down-regulated in colon cancer tissues compared to adjacent colon tissues and acted as a suppressor for Warburg effect in cancer cells. miR-98 inhibited glycolysis by directly targeting hexokinase 2, or HK2, illustrating a novel pathway to mediate Warburg effect of cancer cells. In vitro experiments further indicated that HK2 was involved in miR-98-mediated suppression of glucose uptake, lactate production, and cell proliferation. In addition, we detected HK2 expression in colon cancer tissues and found that the expressions of miR-98 and HK2 were negatively correlated. miR-98 acts as tumor suppressor gene and inhibits Warburg effect in colon cancer cells, which provided potential targets for clinical treatments.

  1. Cancer Stem Cell Theory and the Warburg Effect, Two Sides of the Same Coin?

    Directory of Open Access Journals (Sweden)

    Nicola Pacini

    2014-05-01

    Full Text Available Over the last 100 years, many studies have been performed to determine the biochemical and histopathological phenomena that mark the origin of neoplasms. At the end of the last century, the leading paradigm, which is currently well rooted, considered the origin of neoplasms to be a set of genetic and/or epigenetic mutations, stochastic and independent in a single cell, or rather, a stochastic monoclonal pattern. However, in the last 20 years, two important areas of research have underlined numerous limitations and incongruities of this pattern, the hypothesis of the so-called cancer stem cell theory and a revaluation of several alterations in metabolic networks that are typical of the neoplastic cell, the so-called Warburg effect. Even if this specific “metabolic sign” has been known for more than 85 years, only in the last few years has it been given more attention; therefore, the so-called Warburg hypothesis has been used in multiple and independent surveys. Based on an accurate analysis of a series of considerations and of biophysical thermodynamic events in the literature, we will demonstrate a homogeneous pattern of the cancer stem cell theory, of the Warburg hypothesis and of the stochastic monoclonal pattern; this pattern could contribute considerably as the first basis of the development of a new uniform theory on the origin of neoplasms. Thus, a new possible epistemological paradigm is represented; this paradigm considers the Warburg effect as a specific “metabolic sign” reflecting the stem origin of the neoplastic cell, where, in this specific metabolic order, an essential reason for the genetic instability that is intrinsic to the neoplastic cell is defined.

  2. Optical spectroscopic characteristics of lactate and mitochondrion as new biomarkers in cancer diagnosis: understanding Warburg effect

    Science.gov (United States)

    Liu, C.-H.; Ni, X. H.; Pu, Yang; Yang, Y. L.; Zhou, F.; Zuzolo, R.; Wang, W. B.; Masilamani, V.; Rizwan, A.; Alfano, R. R.

    2012-01-01

    Cancer cells display high rates of glycolysis even under normoxia and mostly under hypoxia. Warburg proposed this effect of altered metabolism in cells more than 80 years ago. It is considered as a hallmark of cancer. Optical spectroscopy can be used to explore this effect. Pathophysiological studies indicate that mitochondria of cancer cells are enlarged and increased in number. Warburg observed that cancer cells tend to convert most glucose to lactate regardless of the presence of oxygen. Previous observations show increased lactate in breast cancer lines. The focus of this study is to investigate the relative content changes of lactate and mitochondria in human cancerous and normal breast tissue samples using optical spectroscopic techniques. The optical spectra were obtained from 30 cancerous and 25 normal breast tissue samples and five model components (Tryptophan, fat, collagen, lactate and mitochondrion) using fluorescence, Stokes shift and Raman spectroscopy. The basic biochemical component analysis model (BBCA) and a set of algorithm were used to analyze the spectra. Our analyses of fluorescence spectra showed a 14 percent increase in lactate content and 2.5 times increase in mitochondria number in cancerous breast tissue as compared with normal tissue. Our findings indicate that optical spectroscopic techniques may be used to understand Warburg effect. Lactate and mitochondrion content changes in tumors examined using optical spectroscopy may be used as a prognostic molecular marker in clinic applications.

  3. Fatty Acid Oxidation Compensates for Lipopolysaccharide-Induced Warburg Effect in Glucose-Deprived Monocytes

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    Nora Raulien

    2017-05-01

    Full Text Available Monocytes enter sites of microbial or sterile inflammation as the first line of defense of the immune system and initiate pro-inflammatory effector mechanisms. We show that activation with bacterial lipopolysaccharide (LPS induces them to undergo a metabolic shift toward aerobic glycolysis, similar to the Warburg effect observed in cancer cells. At sites of inflammation, however, glucose concentrations are often drastically decreased, which prompted us to study monocyte function under conditions of glucose deprivation and abrogated Warburg effect. Experiments using the Seahorse Extracellular Flux Analyzer revealed that limited glucose supply shifts monocyte metabolism toward oxidative phosphorylation, fueled largely by fatty acid oxidation at the expense of lipid droplets. While this metabolic state appears to provide sufficient energy to sustain functional properties like cytokine secretion, migration, and phagocytosis, it cannot prevent a rise in the AMP/ATP ratio and a decreased respiratory burst. The molecular trigger mediating the metabolic shift and the functional consequences is activation of AMP-activated protein kinase (AMPK. Taken together, our results indicate that monocytes are sufficiently metabolically flexible to perform pro-inflammatory functions at sites of inflammation despite glucose deprivation and inhibition of the LPS-induced Warburg effect. AMPK seems to play a pivotal role in orchestrating these processes during glucose deprivation in monocytes.

  4. Pyruvate dehydrogenase kinase inhibition: Reversing the Warburg effect in cancer therapy

    Directory of Open Access Journals (Sweden)

    Hayden Bell

    2016-06-01

    Full Text Available The poor efficacy of many cancer chemotherapeutics, which are often non-selective and highly toxic, is attributable to the remarkable heterogeneity and adaptability of cancer cells. The Warburg effect describes the up regulation of glycolysis as the main source of adenosine 5’-triphosphate in cancer cells, even under normoxic conditions, and is a unique metabolic phenotype of cancer cells. Mitochondrial suppression is also observed which may be implicated in apoptotic suppression and increased funneling of respiratory substrates to anabolic processes, conferring a survival advantage. The mitochondrial pyruvate dehydrogenase complex is subject to meticulous regulation, chiefly by pyruvate dehydrogenase kinase. At the interface between glycolysis and the tricarboxylic acid cycle, the pyruvate dehydrogenase complex functions as a metabolic gatekeeper in determining the fate of glucose, making pyruvate dehydrogenase kinase an attractive candidate in a bid to reverse the Warburg effect in cancer cells. The small pyruvate dehydrogenase kinase inhibitor dichloroacetate has, historically, been used in conditions associated with lactic acidosis but has since gained substantial interest as a potential cancer chemotherapeutic. This review considers the Warburg effect as a unique phenotype of cancer cells in-line with the history of and current approaches to cancer therapies based on pyruvate dehydrogenase kinase inhibition with particular reference to dichloroacetate and its derivatives.

  5. Academic freedom and the professional responsibilities of applied ethicists: a comment on Minerva.

    Science.gov (United States)

    Dawson, Angus; Herington, Jonathan

    2014-05-01

    Academic freedom is an important good, but it comes with several responsibilities. In this commentary we seek to do two things. First, we argue against Francesca Minerva's view of academic freedom as presented in her article 'New threats to academic freedom' on a number of grounds. We reject the nature of the absolutist moral claim to free speech for academics implicit in the article; we reject the elitist role for academics as truth-seekers explicit in her view; and we reject a possible more moderate re-construction of her view based on the harm/offence distinction. Second, we identify some of the responsibilities of applied ethicists, and illustrate how they recommend against allowing for anonymous publication of research. Such a proposal points to the wider perils of a public discourse which eschews the calm and careful discussion of ideas. © 2014 John Wiley & Sons Ltd.

  6. Measurement of Muon Neutrino Charged Current Single $\\pi^0$ Production on Hydrocarbon using MINERvA

    Energy Technology Data Exchange (ETDEWEB)

    Altinok, Ozgur [Tufts Univ., Medford, MA (United States)

    2017-01-01

    A sample of charged-current single pion production events for the semi- exclusive channel νµ + CH → µ-π0 + nucleon(s) has been obtained using neutrino exposures of the MINERvA detector. Differential cross sections for muon momentum, muon production angle, pion momentum, pion production angle, and four-momentum transfer square Q2 are reported and are compared to a GENIE-based simulation. The cross section versus neutrino energy is also re- ported. The effects of pion final-state interactions on these cross sections are investigated. The effect of baryon resonance suppression at low Q2 is examined and an event re-weight used by two previous experiments is shown to improve the data versus simulation agreement. The differential cross sections for Q2 for Eν < 4.0 GeV and Eν ≥ 4.0 GeV are examined and the shapes of these distributions are compared to those from the experiment’s $\\bar{v}$µ-CC (π0) measurement. The polarization of the pπ0 system is measured and compared to the simulation predictions. The hadronic invariant mass W distribution is examined for evidence of resonance content, and a search is reported for evidence of a two-particle two-hole (2p2h) contribution. All of the differential cross-section measurements of this Thesis are compared with published MINERvA measurements for νµ-CC (π+) and \\bar{v}$µ-CC (π0) processes.

  7. Pentachlorophenol exposure causes Warburg-like effects in zebrafish embryos at gastrulation stage

    International Nuclear Information System (INIS)

    Xu, Ting; Zhao, Jing; Hu, Ping; Dong, Zhangji; Li, Jingyun; Zhang, Hongchang; Yin, Daqiang; Zhao, Qingshun

    2014-01-01

    Pentachlorophenol (PCP) is a prevalent pollutant in the environment and has been demonstrated to be a serious toxicant to humans and animals. However, little is known regarding the molecular mechanism underlying its toxic effects on vertebrate early development. To explore the impacts and underlying mechanisms of PCP on early development, zebrafish (Danio rerio) embryos were exposed to PCP at concentrations of 0, 20 and 50 μg/L, and microscopic observation and cDNA microarray analysis were subsequently conducted at gastrulation stage. The morphological observations revealed that PCP caused a developmental delay of zebrafish embryos in a concentration-dependent manner. Transcriptomic data showed that 50 μg/L PCP treatment resulted in significant changes in gene expression level, and the genes involved in energy metabolism and cell behavior were identified based on gene functional enrichment analysis. The energy production of embryos was influenced by PCP via the activation of glycolysis along with the inhibition of oxidative phosphorylation (OXPHOS). The results suggested that PCP acts as an inhibitor of OXPHOS at 8 hpf (hours postfertilization). Consistent with the activated glycolysis, the cell cycle activity of PCP-treated embryos was higher than the controls. These characteristics are similar to the Warburg effect, which occurs in human tumors. The microinjection of exogenous ATP confirmed that an additional energy supply could rescue PCP-treated embryos from the developmental delay due to the energy deficit. Taken together, our results demonstrated that PCP causes a Warburg-like effect on zebrafish embryos during gastrulation, and the affected embryos had the phenotype of developmental delay. - Highlights: • We treat zebrafish embryos with PCP at gastrula stage. • PCP acts as an oxidative phosphorylation inhibitor, not an uncoupler, in gastrulation. • Exogenous ATP injection will rescue the development of effected embryos. • The transcriptome of PCP

  8. Pentachlorophenol exposure causes Warburg-like effects in zebrafish embryos at gastrulation stage

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Ting; Zhao, Jing [Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Technology, Tongji University, Shanghai 200092 (China); Hu, Ping [Key Laboratory of Model Animal for Disease Study, Ministry of Education, Model Animal Research Center, Nanjing University, Nanjing 210061 (China); State Key Laboratory of Reproductive Medicine, Department of Prenatal Diagnosis, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing 210029 (China); Dong, Zhangji; Li, Jingyun [Key Laboratory of Model Animal for Disease Study, Ministry of Education, Model Animal Research Center, Nanjing University, Nanjing 210061 (China); Zhang, Hongchang [Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Technology, Tongji University, Shanghai 200092 (China); Yin, Daqiang, E-mail: yindq@tongji.edu.cn [Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Technology, Tongji University, Shanghai 200092 (China); Zhao, Qingshun, E-mail: qingshun@nju.edu.cn [Key Laboratory of Model Animal for Disease Study, Ministry of Education, Model Animal Research Center, Nanjing University, Nanjing 210061 (China)

    2014-06-01

    Pentachlorophenol (PCP) is a prevalent pollutant in the environment and has been demonstrated to be a serious toxicant to humans and animals. However, little is known regarding the molecular mechanism underlying its toxic effects on vertebrate early development. To explore the impacts and underlying mechanisms of PCP on early development, zebrafish (Danio rerio) embryos were exposed to PCP at concentrations of 0, 20 and 50 μg/L, and microscopic observation and cDNA microarray analysis were subsequently conducted at gastrulation stage. The morphological observations revealed that PCP caused a developmental delay of zebrafish embryos in a concentration-dependent manner. Transcriptomic data showed that 50 μg/L PCP treatment resulted in significant changes in gene expression level, and the genes involved in energy metabolism and cell behavior were identified based on gene functional enrichment analysis. The energy production of embryos was influenced by PCP via the activation of glycolysis along with the inhibition of oxidative phosphorylation (OXPHOS). The results suggested that PCP acts as an inhibitor of OXPHOS at 8 hpf (hours postfertilization). Consistent with the activated glycolysis, the cell cycle activity of PCP-treated embryos was higher than the controls. These characteristics are similar to the Warburg effect, which occurs in human tumors. The microinjection of exogenous ATP confirmed that an additional energy supply could rescue PCP-treated embryos from the developmental delay due to the energy deficit. Taken together, our results demonstrated that PCP causes a Warburg-like effect on zebrafish embryos during gastrulation, and the affected embryos had the phenotype of developmental delay. - Highlights: • We treat zebrafish embryos with PCP at gastrula stage. • PCP acts as an oxidative phosphorylation inhibitor, not an uncoupler, in gastrulation. • Exogenous ATP injection will rescue the development of effected embryos. • The transcriptome of PCP

  9. Norrie-Warburg syndrome: two novel mutations in patients with classical clinical phenotype.

    Science.gov (United States)

    Gal, A; Veske, A; Jojart, G; Grammatico, B; Huber, B; Gu, S; del Porto, G; Senyi, K

    1996-01-01

    Norrie-Warburg syndrome (NWS) is a rare X-linked disorder characterized by blindness, which is invariable, deafness and mental disturbances, which are present occasionally. We describe here two novel mutations, a missense mutation (C126S) and a 1-base pair insertion (insT466/T467), together with a recurrent mutation (M1V), found in patients presenting with the classical clinical phenotype of NWS. All three mutations are likely to result in prominent structural changes of the norrin protein.

  10. The afterlife of antiquity and modern art: Aby Warburg on Manet

    Directory of Open Access Journals (Sweden)

    Dimitrios Latsis

    2015-12-01

    Full Text Available Aby Warburg’s manuscript on Édouard Manet – unpublished during his lifetime and presented here for the first time in English – constitutes one of his rare, substantial commentaries on nineteenth century art. Using “Le Déjeuner sur l’herbe” as a departure point, Warburg proceeds from his customary meticulous investigation of the central motif’s “visual archeology,” to a larger reflection on the evolution of the representation of nature in art and the image of antiquity that modernity has created for itself.

  11. Under a Starry Vault. Warburg, Jung and the Renaissance of Ancient Paganisms at the Beginning of the 20th Century

    Directory of Open Access Journals (Sweden)

    Manuela Pallotto Strickland

    2015-11-01

    Full Text Available The paper tackles the controversial question of the affinities between the work of Aby Warburg and Carl Gustav Jung. Instead of focussing her interest exclusively on the concepts of collective memory and primordial images, though, the author critically compares the different ways Warburg and Jung looked at the renaissance of ancient practices of Paganism at the beginning of the Twentieth century, and questions the extent to which the cultural crisis heralded by Modernity, and the challenges brought about by secularisation influenced their reading of the revivals.

  12. Anestesia em criança com síndrome de Walker-Warburg

    Directory of Open Access Journals (Sweden)

    Emine Arzu Kose

    2014-04-01

    Full Text Available Justificativa e objetivos: A síndrome de Walker-Warburg é uma distrofia muscular autossômica recessiva congênita rara, manifestada pelo sistema nervoso central com malformações oculares e possível envolvimento de vários sistemas. O diagnóstico é estabelecido pela presença de quatro critérios: distrofia muscular congênita, lisencefalia tipo II, malformação cerebelar e malformação da retina. A maioria das crianças com a síndrome morre nos primeiros três anos de vida por causa de insuficiência respiratória, pneumonia, convulsões, hipertermia e fibrilação ventricular. Relato de caso: É discutida a conduta anestésica em uma criança do sexo masculino, de dois meses, programada para cirurgia eletiva de derivação ventrículo-peritoneal. Conclusões: Uma abordagem anestésica cuidadosa é necessária por causa do envolvimento de vários sistemas. Relatamos a conduta anestésica em uma criança do sexo masculino de dois meses com síndrome de Walker-Warburg, que foi programada para cirurgia eletiva de derivação ventrículo-peritoneal.

  13. POMT1-associated walker-warburg syndrome: a disorder of dendritic development of neocortical neurons.

    Science.gov (United States)

    Judas, M; Sedmak, G; Rados, M; Sarnavka, V; Fumić, K; Willer, T; Gross, C; Hehr, U; Strahl, S; Cuk, M; Barić, I

    2009-02-01

    We have analyzed the morphology and dendritic development of neocortical neurons in a 2.5-month-old infant with Walker-Warburg syndrome homozygotic for a novel POMT1 gene mutation, by Golgi methods. We found that pyramidal neurons frequently displayed abnormal (oblique, horizontal, or inverted) orientation. A novel finding of this study is that members of the same population of pyramidal neurons display different stages of development of their dendritic arborizations: some neurons had poorly developed dendrites and thus resembled pyramidal neurons of the late fetal cortex; for some neurons, the level of differentiation corresponded to that in the newborn cortex; finally, some neurons had quite elaborate dendritic trees as expected for the cortex of 2.5-month-old infant. In addition, apical dendrites of many pyramidal neurons were conspiciously bent to one side, irrespective to the general orientation of the pyramidal neuron. These findings suggest that Walker-Warburg lissencephaly is characterized by two hitherto unnoticed pathogenetic changes in the cerebral cortex: (a) heterochronic decoupling of dendritic maturation within the same neuronal population (with some members significantly lagging behind the normal maturational schedule) and (b) anisotropically distorted shaping of dendritic trees, probably caused by patchy displacement of molecular guidance cues for dendrites in the malformed cortex. Copyright Georg Thieme Verlag KG Stuttgart New York.

  14. The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancer.

    Directory of Open Access Journals (Sweden)

    Christoph Ruckenstuhl

    Full Text Available BACKGROUND: Otto Warburg observed that cancer cells are often characterized by intense glycolysis in the presence of oxygen and a concomitant decrease in mitochondrial respiration. Research has mainly focused on a possible connection between increased glycolysis and tumor development whereas decreased respiration has largely been left unattended. Therefore, a causal relation between decreased respiration and tumorigenesis has not been demonstrated. METHODOLOGY/PRINCIPAL FINDINGS: For this purpose, colonies of Saccharomyces cerevisiae, which is suitable for manipulation of mitochondrial respiration and shows mitochondria-mediated cell death, were used as a model. Repression of respiration as well as ROS-scavenging via glutathione inhibited apoptosis and conferred a survival advantage during seeding and early development of this fast proliferating solid cell population. In contrast, enhancement of respiration triggered cell death. CONCLUSION/SIGNIFICANCE: Thus, the Warburg effect might directly contribute to the initiation of cancer formation--not only by enhanced glycolysis--but also via decreased respiration in the presence of oxygen, which suppresses apoptosis.

  15. Measurement of Neutral-Current K+ Production by Neutrinos using MINERvA

    Science.gov (United States)

    Marshall, C. M.; Aliaga, L.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Cai, T.; Carneiro, M. F.; da Motta, H.; Dytman, S. A.; Díaz, G. A.; Dunkman, M.; Eberly, B.; Endress, E.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Gallagher, H.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Hurtado, K.; Kleykamp, J.; Kordosky, M.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Caicedo, D. A. Martinez; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Mousseau, J.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman; Paolone, V.; Patrick, C. E.; Perdue, G. N.; Ramírez, M. A.; Ransome, R. D.; Ray, H.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schmitz, D. W.; Solano Salinas, C. J.; Sultana, M.; Sánchez Falero, S.; Valencia, E.; Walton, T.; Wolcott, J.; Wospakrik, M.; Yaeggy, B.; Zhang, D.; Minerva Collaboration

    2017-07-01

    Neutral-current production of K+ by atmospheric neutrinos is a background in searches for the proton decay p →K+ν ¯. Reactions such as ν p →ν K+Λ are indistinguishable from proton decays when the decay products of the Λ are below detection threshold. Events with K+ are identified in MINERvA by reconstructing the timing signature of a K+ decay at rest. A sample of 201 neutrino-induced neutral-current K+ events is used to measure differential cross sections with respect to the K+ kinetic energy, and the non-K+ hadronic visible energy. An excess of events at low hadronic visible energy is observed relative to the prediction of the neut event generator. Good agreement is observed with the cross section prediction of the genie generator. A search for photons from π0 decay, which would veto a neutral-current K+ event in a proton decay search, is performed, and a 2 σ deficit of detached photons is observed relative to the genie prediction.

  16. The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate.

    Science.gov (United States)

    Lis, Paweł; Dyląg, Mariusz; Niedźwiecka, Katarzyna; Ko, Young H; Pedersen, Peter L; Goffeau, Andre; Ułaszewski, Stanisław

    2016-12-15

    This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the "Warburg" and "Crabtree" effects. This work also summarizes two key discoveries, one of which relates to hexokinase-2 (HK2), a major player in both the "Warburg effect" and cancer cell immortalization. The second discovery relates to the finding that cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the "Warburg effect", and the remaining 40% is derived from mitochondrial oxidative phosphorylation. Also described are selected anticancer agents which generally act as strong energy blockers inside cancer cells. Among them, much attention has focused on 3-bromopyruvate (3BP). This small alkylating compound targets both the "Warburg effect", i.e., elevated glycolysis even in the presence oxygen, as well as mitochondrial oxidative phosphorylation in cancer cells. Normal cells remain unharmed. 3BP rapidly kills cancer cells growing in tissue culture, eradicates tumors in animals, and prevents metastasis. In addition, properly formulated 3BP shows promise also as an effective anti-liver cancer agent in humans and is effective also toward cancers known as "multiple myeloma". Finally, 3BP has been shown to significantly extend the life of a human patient for which no other options were available. Thus, it can be stated that 3BP is a very promising new anti-cancer agent in the process of undergoing clinical development.

  17. PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway

    Directory of Open Access Journals (Sweden)

    Yunbin Xiao

    2017-07-01

    Full Text Available Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs is a central pathological component in pulmonary arterial hypertension (PAH. Both the Warburg effect and platelet-derived growth factor (PDGF are involved in the proliferation of PASMCs. However, the mechanism underlying the crosstalk between the Warburg effect and PDGF during PASMC proliferation is still unknown. We hypothesized that PDGF promotes the Warburg effect via activating the phosphatidylinositol 3-kinase (PI3K signaling pathway and hypoxia-inducible factor 1-α (HIF-1α in proliferative PASMCs. Methods: PASMCs were derived from pulmonary arteries of SD rats; cell viability, the presence of metabolites, and metabolic enzyme activities assay were determined by MTT assays, kit assays and western blot analysis, respectively. Results: PDGF promoted PASMC proliferation in a dose- and time-dependent manner, accompanied by an enhanced Warburg effect. Treatment with PDGFR antagonists, Warburg effect inhibitor and PDK1 inhibitor significantly inhibited PI3K signaling activation, HIF-1α expression and PASMC proliferation induced by PDGF, respectively. Furthermore, treatment with PI3K signaling pathway inhibitors remarkably suppressed PDGF-induced PASMC proliferation and the Warburg effect. Conclusion: microplate reader (Biotek, Winooski The Warburg effect plays a critical role in PDGF-induced PASMC proliferation and is mediated by activation of the PI3K signaling pathway and HIF-1α.

  18. Efficacy and patient satisfaction after NovaSure and Minerva endometrial ablation for treating abnormal uterine bleeding: a retrospective comparative study.

    Science.gov (United States)

    Scordalakes, Constantine; delRosario, Robert; Shimer, Andrew; Stankiewicz, Russell

    2018-01-01

    Compare amenorrhea rate, menstrual symptoms, patient satisfaction, and adverse events in women who underwent endometrial ablation with the NovaSure versus the Minerva radiofrequency ablation systems. We surveyed 189 premenopausal women (mean 40.8±6.2 years old) who underwent endometrial ablation for abnormal uterine bleeding using the NovaSure (n=97) or Minerva (n=92) systems, at four private US gynecology clinics, and whose procedure date was after July 2015 with follow-up ≥3 months. Women were surveyed an average of 11.3±3.9 months (range 137-532 days) after ablation. The subject-reported amenorrhea rate was 52% higher in NovaSure subjects than Minerva subjects (64% and 42%, respectively; p =0.004). Age and bleeding cyclicity did not affect amenorrhea rate in either group. Normal-to-no bleeding was reported by >90% of subjects after either treatment. NovaSure was significantly more effective than Minerva at reducing pad/tampon use in women with any residual bleeding (2.4±5.2 items/day versus 4.7±5.5 items/day, p =0.049). NovaSure was significantly more effective than Minerva at reducing premenstrual syndrome (PMS) symptoms ( p =0.019) and menstrual pain ( p =0.003), and more NovaSure subjects (94%) than Minerva subjects (78%) were satisfied with clinical outcomes ( p =0.003). Adverse events did not differ by treatment; three women in each group progressed to hysterectomy. While overall bleeding reduction in premenopausal women with abnormal uterine bleeding was excellent with either endometrial ablation system, NovaSure treatment resulted in a higher patient-reported 1-year amenorrhea rate, and women with residual bleeding used fewer pads and tampons than Minerva-treated women. Additionally, NovaSure subjects reported better menstrual-related life quality and PMS symptom alleviation, and greater satisfaction with outcomes than Minerva-treated women.

  19. Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes.

    Directory of Open Access Journals (Sweden)

    Zhen Li

    Full Text Available Previously we have generated inducible liver tumor models by transgenic expression of Myc or xmrk (activated EGFR homolog oncogenes in zebrafish. To investigate the interaction of the two oncogenes, we crossed the two transgenic lines and observed more severe and faster hepatocarcinogenesis in Myc/xmrk double transgenic zebrafish than either single transgenic fish. RNA-Seq analyses revealed distinct changes in many molecular pathways among the three types of liver tumors. In particular, we found dramatic alteration of cancer metabolism based on the uniquely enriched pathways in the Myc/xmrk tumors. Critical glycolytic genes including hk2, pkm and ldha were significantly up-regulated in Myc/xmrk tumors but not in either single oncogene-induced tumors, suggesting a potential Warburg effect. In RT-qPCR analyses, the specific pkm2 isoformin Warburg effect was found to be highly enriched in the Myc/xmrk tumors but not in Myc or xmrk tumors, consistent with the observations in many human cancers with Warburg effect. Moreover, the splicing factor genes (hnrnpa1, ptbp1a, ptbp1b and sfrs3b responsible for generating the pkm isoform were also greatly up-regulated in the Myc/xmrk tumors. As Pkm2 isoform is generally inactive and causes incomplete glycolysis to favor anabolism and tumor growth, by treatment with a Pkm2-specific activator, TEPP-46, we further demonstrated that activation of Pkm2 suppressed the growth of oncogenic liver as well as proliferation of liver cells. Collectively, our Myc/xmrk zebrafish model suggests synergetic effect of EGFR and MYC in triggering Warburg effect in the HCC formation and may provide a promising in vivo model for Warburg effect.

  20. Impact of exploratory offshore drilling on benthic communities in the Minerva gas field, Port Campbell, Australia

    Energy Technology Data Exchange (ETDEWEB)

    Currie, D.R.; Isaacs, L.R. [Central Queensland Univ., Gladstone (Australia). Centre for Environmental Management

    2005-04-01

    Changes to benthic infauna caused by exploratory gas drilling operations in the Minerva field were examined experimentally using a BACI (before, after, control, impact) design. Analysis of 72 x 0.1 m{sup 2} Smith-McIntyre grab samples obtained from one pre-drilling and three post-drilling periods yielded a diverse fauna consisting of 196 invertebrate species and 5035 individuals. Changes to benthic community structure were assessed using ANOVA and nonmetric multidimensional scaling (MDS). The abundances of two common species (Apseudes sp. 1 and Prionospio coorilla) decreased significantly at the well-head site immediately after drilling. The size of these reductions in abundance ranged between 71% and 88%, and persisted for less than 4 months after drilling. A third common species (Katlysia sp. 1) increased in abundance 200 m east of the well-head following drilling. Most species occurred at densities too low to be analysed individually and so were pooled at higher taxonomic levels. Changes in the abundance of species aggregated by phylum varied, but significant declines in the most abundant phyla (Crustaceans and Polychaetes) of 45-73% were observed at all sites within a 100 m radius of the well-head following drilling. In most cases these changes became undetectable four months after drilling following species recruitments. MDS ordinations confirm that drilling related changes to benthic community structure are most pronounced at stations located closest to the well-head. Additionally, the ordinations indicate that modified communities persist at the well-head for more than 11 months following exploratory drilling. (author)

  1. Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells.

    Directory of Open Access Journals (Sweden)

    Ana M Sanchez-Sanchez

    Full Text Available Melatonin kills or inhibits the proliferation of different cancer cell types, and this is associated with an increase or a decrease in reactive oxygen species, respectively. Intracellular oxidants originate mainly from oxidative metabolism, and cancer cells frequently show alterations in this metabolic pathway, such as the Warburg effect (aerobic glycolysis. Thus, we hypothesized that melatonin could also regulate differentially oxidative metabolism in cells where it is cytotoxic (Ewing sarcoma cells and in cells where it inhibits proliferation (chondrosarcoma cells. Ewing sarcoma cells but not chondrosarcoma cells showed a metabolic profile consistent with aerobic glycolysis, i.e. increased glucose uptake, LDH activity, lactate production and HIF-1α activation. Melatonin reversed Ewing sarcoma metabolic profile and this effect was associated with its cytotoxicity. The differential regulation of metabolism by melatonin could explain why the hormone is harmless for a wide spectrum of normal and only a few tumoral cells, while it kills specific tumor cell types.

  2. Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells

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    Bradley Smith

    2016-10-01

    Full Text Available Metabolic reprogramming is critical to oncogenesis, but the emergence and function of this profound reorganization remain poorly understood. Here we find that cooperating oncogenic mutations drive large-scale metabolic reprogramming, which is both intrinsic to cancer cells and obligatory for the transition to malignancy. This involves synergistic regulation of several genes encoding metabolic enzymes, including the lactate dehydrogenases LDHA and LDHB and mitochondrial glutamic pyruvate transaminase 2 (GPT2. Notably, GPT2 engages activated glycolysis to drive the utilization of glutamine as a carbon source for TCA cycle anaplerosis in colon cancer cells. Our data indicate that the Warburg effect supports oncogenesis via GPT2-mediated coupling of pyruvate production to glutamine catabolism. Although critical to the cancer phenotype, GPT2 activity is dispensable in cells that are not fully transformed, thus pinpointing a metabolic vulnerability specifically associated with cancer cell progression to malignancy.

  3. Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells

    International Nuclear Information System (INIS)

    Tosato, Valentina; Grüning, Nana-Maria; Breitenbach, Michael; Arnak, Remigiusz; Ralser, Markus; Bruschi, Carlo V.

    2013-01-01

    Yeast has been established as an efficient model system to study biological principles underpinning human health. In this review we focus on yeast models covering two aspects of cancer formation and progression (i) the activity of pyruvate kinase (PK), which recapitulates metabolic features of cancer cells, including the Warburg effect, and (ii) chromosome bridge-induced translocation (BIT) mimiking genome instability in cancer. Saccharomyces cerevisiae is an excellent model to study cancer cell metabolism, as exponentially growing yeast cells exhibit many metabolic similarities with rapidly proliferating cancer cells. The metabolic reconfiguration includes an increase in glucose uptake and fermentation, at the expense of respiration and oxidative phosphorylation (the Warburg effect), and involves a broad reconfiguration of nucleotide and amino acid metabolism. Both in yeast and humans, the regulation of this process seems to have a central player, PK, which is up-regulated in cancer, and to occur mostly on a post-transcriptional and post-translational basis. Furthermore, BIT allows to generate selectable translocation-derived recombinants (“translocants”), between any two desired chromosomal locations, in wild-type yeast strains transformed with a linear DNA cassette carrying a selectable marker flanked by two DNA sequences homologous to different chromosomes. Using the BIT system, targeted non-reciprocal translocations in mitosis are easily inducible. An extensive collection of different yeast translocants exhibiting genome instability and aberrant phenotypes similar to cancer cells has been produced and subjected to analysis. In this review, we hence provide an overview upon two yeast cancer models, and extrapolate general principles for mimicking human disease mechanisms in yeast.

  4. WARBURG EFFECT AND TRANSLOCATION-INDUCED GENOMIC INSTABILITY: TWO YEAST MODELS FOR CANCER CELLS

    Directory of Open Access Journals (Sweden)

    Valentina eTosato

    2013-01-01

    Full Text Available Yeast has been established as an efficient model system to study biological principles underpinning human health. In this review we focus on yeast models covering two aspects of cancer formation and progression i the activity of pyruvate kinase (PK, which recapitulates metabolic features of cancer cells, including the Warburg effect, and ii Bridge-Induced chromosome Translocation (BIT mimicking genome instability in cancer. Saccharomyces cerevisiae is an excellent model to study cancer cell metabolism, as exponentially growing yeast cells exhibit many metabolic similarities with rapidly proliferating cancer cells. The metabolic reconfiguration includes an increase in glucose uptake and fermentation, at the expense of respiration and oxidative phosphorylation (the Warburg effect, and involves a broad reconfiguration of nucleotide and amino acid metabolism. Both in yeast and humans, the regulation of this process seems to have a central player, pyruvate kinase, which is up-regulated in cancer, and to occur mostly on a post-transcriptional and posttranslational basis. Furthermore, BIT allows to generate selectable translocation-derived recombinants (translocants, between any two desired chromosomal locations, in wild-type yeast strains transformed with a linear DNA cassette carrying a selectable marker flanked by two DNA sequences homologous to different chromosomes. Using the Bridge-Induced Translocation system, targeted non-reciprocal translocations in mitosis are easily inducible. An extensive collection of different yeast translocants exhibiting genome instability and aberrant phenotypes similar to cancer cells has been produced and subjected to analysis. In this review, we hence provide an overview upon two yeast cancer models, and extrapolate general principles for mimicking human disease mechanisms in yeast.

  5. Heterogeneity and proliferation of invasive cancer subclones in game theory models of the Warburg effect.

    Science.gov (United States)

    Archetti, M

    2015-04-01

    The Warburg effect, a switch from aerobic energy production to anaerobic glycolysis, promotes tumour proliferation and motility by inducing acidification of the tumour microenvironment. Therapies that reduce acidity could impair tumour growth and invasiveness. I analysed the dynamics of cell proliferation and of resistance to therapies that target acidity, in a population of cells, under the Warburg effect. The dynamics of mutant cells with increased glycolysis and motility has been assessed in a multi-player game with collective interactions in the framework of evolutionary game theory. Perturbations of the level of acidity in the microenvironment have been used to simulate the effect of therapies that target glycolysis. The non-linear effects of glycolysis induce frequency-dependent clonal selection leading to coexistence of glycolytic and non-glycolytic cells within a tumour. Mutants with increased motility can invade such a polymorphic population and spread within the tumour. While reducing acidity may produce a sudden reduction in tumour cell proliferation, frequency-dependent selection enables it to adapt to the new conditions and can enable the tumour to restore its original levels of growth and invasiveness. The acidity produced by glycolysis acts as a non-linear public good that leads to coexistence of cells with high and low glycolysis within the tumour. Such a heterogeneous population can easily adapt to changes in acidity. Therapies that target acidity can only be effective in the long term if the cost of glycolysis is high, that is, under non-limiting oxygen concentrations. Their efficacy, therefore, is reduced when combined with therapies that impair angiogenesis. © 2015 The Authors Cell Proliferation Published by John Wiley & Sons Ltd.

  6. Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Tosato, Valentina [International Centre for Genetic Engineering and Biotechnology, Trieste (Italy); Grüning, Nana-Maria [Cambridge System Biology Center, Department of Biochemistry, University of Cambridge, Cambridge (United Kingdom); Breitenbach, Michael [Division of Genetics, Department of Cell Biology, University of Salzburg, Salzburg (Austria); Arnak, Remigiusz [International Centre for Genetic Engineering and Biotechnology, Trieste (Italy); Ralser, Markus [Cambridge System Biology Center, Department of Biochemistry, University of Cambridge, Cambridge (United Kingdom); Bruschi, Carlo V., E-mail: bruschi@icgeb.org [International Centre for Genetic Engineering and Biotechnology, Trieste (Italy)

    2013-01-18

    Yeast has been established as an efficient model system to study biological principles underpinning human health. In this review we focus on yeast models covering two aspects of cancer formation and progression (i) the activity of pyruvate kinase (PK), which recapitulates metabolic features of cancer cells, including the Warburg effect, and (ii) chromosome bridge-induced translocation (BIT) mimiking genome instability in cancer. Saccharomyces cerevisiae is an excellent model to study cancer cell metabolism, as exponentially growing yeast cells exhibit many metabolic similarities with rapidly proliferating cancer cells. The metabolic reconfiguration includes an increase in glucose uptake and fermentation, at the expense of respiration and oxidative phosphorylation (the Warburg effect), and involves a broad reconfiguration of nucleotide and amino acid metabolism. Both in yeast and humans, the regulation of this process seems to have a central player, PK, which is up-regulated in cancer, and to occur mostly on a post-transcriptional and post-translational basis. Furthermore, BIT allows to generate selectable translocation-derived recombinants (“translocants”), between any two desired chromosomal locations, in wild-type yeast strains transformed with a linear DNA cassette carrying a selectable marker flanked by two DNA sequences homologous to different chromosomes. Using the BIT system, targeted non-reciprocal translocations in mitosis are easily inducible. An extensive collection of different yeast translocants exhibiting genome instability and aberrant phenotypes similar to cancer cells has been produced and subjected to analysis. In this review, we hence provide an overview upon two yeast cancer models, and extrapolate general principles for mimicking human disease mechanisms in yeast.

  7. Project Minerva: A low-cost manned Mars mission based on indigenous propellant production

    Science.gov (United States)

    Bruckner, Adam P.; Anderson, Hobie; Caviezel, Kelly; Daggert, Todd; Folkers, Mike; Fornia, Mark; Hamling, Steven; Johnson, Bryan; Kalberer, Martin; Machula, Mike

    1992-01-01

    Project Minerva is a low-cost manned Mars mission designed to deliver a crew of four to the Martian surface, using only two sets of two launches. Key concepts which make this mission realizable are the use of near-term technologies and in-situ propellant production, following the senario originally proposed by R. Zubrin of Martin Marietta. The first set of launches delivers two unmanned payloads into low earth orbit (LEO): one consists of an Earth Return Vehicle (ERV), a propellant production plant, and a set of robotic vehicles, and the second consists of the upper stage/trans-Mars injection (TMI) booster. In LEO, the two payloads are joined and inserted into a Mars transfer orbit. The landing on Mars is performed with the aid of multiple aerobraking maneuvers. On the Martian surface, the propellant production plant uses a Sabatier/electrolysis-type process to combine six tons of hydrogen brought from earth with carbon dioxide from the Martian atmosphere to produce 100 tons of liquid oxygen and methane, which are later used as the propellants for the rover expeditions and the manned return journey of the ERV. Once the in-situ propellant production is completed, approximately two years after the first set of launches, the manned portion of the mission leaves earth. This set of two launches is similar to that of the unmanned vehicles; the two payloads are the Manned Transfer Vehicle (MTV) and the upper stage/TMI booster. The MTV contains the manned rover and the habitat which houses the astronauts enroute to Mars and on the Martian surface. During the 180-day trip to Mars, artificial gravity is created by tethering the MTV to the TMI booster and inducing rotation. Upon arrival the MTV performs aerobraking maneuvers to land near the fully-fueled ERV, which will be used by the crew a year and a half later to return to earth. The mission entails moderate travel times with relatively low-energy conjunction-class trajectories and allows ample time for scientific

  8. White spot syndrome virus induces metabolic changes resembling the warburg effect in shrimp hemocytes in the early stage of infection.

    Science.gov (United States)

    Chen, I-Tung; Aoki, Takashi; Huang, Yun-Tzu; Hirono, Ikuo; Chen, Tsan-Chi; Huang, Jiun-Yan; Chang, Geen-Dong; Lo, Chu-Fang; Wang, Han-Ching

    2011-12-01

    The Warburg effect is an abnormal glycolysis response that is associated with cancer cells. Here we present evidence that metabolic changes resembling the Warburg effect are induced by a nonmammalian virus. When shrimp were infected with white spot syndrome virus (WSSV), changes were induced in several metabolic pathways related to the mitochondria. At the viral genome replication stage (12 h postinfection [hpi]), glucose consumption and plasma lactate concentration were both increased in WSSV-infected shrimp, and the key enzyme of the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PDH), showed increased activity. We also found that at 12 hpi there was no alteration in the ADP/ATP ratio and that oxidative stress was lower than that in uninfected controls. All of these results are characteristic of the Warburg effect as it is present in mammals. There was also a significant decrease in triglyceride concentration starting at 12 hpi. At the late stage of the infection cycle (24 hpi), hemocytes of WSSV-infected shrimp showed several changes associated with cell death. These included the induction of mitochondrial membrane permeabilization (MMP), increased oxidative stress, decreased glucose consumption, and disrupted energy production. A previous study showed that WSSV infection led to upregulation of the voltage-dependent anion channel (VDAC), which is known to be involved in both the Warburg effect and MMP. Here we show that double-stranded RNA (dsRNA) silencing of the VDAC reduces WSSV-induced mortality and virion copy number. For these results, we hypothesize a model depicting the metabolic changes in host cells at the early and late stages of WSSV infection.

  9. Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas

    Science.gov (United States)

    Li, Yaqing; Li, Xiaoran; Kan, Quancheng; Zhang, Mingzhi; Li, Xiaoli; Xu, Ruiping; Wang, Junsheng; Yu, Dandan; Goscinski, Mariusz Adam; Wen, Jian-Guo; Nesland, Jahn M.; Suo, Zhenhe

    2017-01-01

    Aerobic glycolysis is one of the emerging hallmarks of cancer cells. In this study, we investigated the relationship between blocking mitochondrial pyruvate carrier (MPC) with MPC blocker UK5099 and the metabolic alteration as well as aggressive features of esophageal squamous carcinoma. It was found that blocking pyruvate transportation into mitochondria attenuated mitochondrial oxidative phosphorylation (OXPHOS) and triggered aerobic glycolysis, a feature of Warburg effect. In addition, the HIF-1α expression and ROS production were also activated upon UK5099 application. It was further revealed that the UK5099-treated cells became significantly more resistant to chemotherapy and radiotherapy, and the UK5099-treated tumor cells also exhibited stronger invasive capacity compared to the parental cells. In contrast to esophageal squamous epithelium cells, decreased MPC protein expression was observed in a series of 157 human squamous cell carcinomas, and low/negative MPC1 expression predicted an unfavorable clinical outcome. All these results together revealed the potential connection of altered MPC expression/activity with the Warburg metabolic reprogramming and tumor aggressiveness in cell lines and clinical samples. Collectively, our findings highlighted a therapeutic strategy targeting Warburg reprogramming of human esophageal squamous cell carcinomas. PMID:27911865

  10. Warburg effect regulated by amphiregulin in the development of colorectal cancer

    International Nuclear Information System (INIS)

    Nam, Sung Ouk; Yotsumoto, Fusanori; Miyata, Kohei; Fukagawa, Satoshi; Yamada, Hiromi; Kuroki, Masahide; Miyamoto, Shingo

    2015-01-01

    Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality worldwide. Amphiregulin (AREG), a member of the epidermal growth factor family and a rational target for CRC therapy, is essential for the three-dimensional structure of tumor formation. To clone the genes associated with increased AREG expression, we performed a cDNA microarray analysis in two CRC cell lines undergoing two-dimensional (2DC) and three-dimensional culture (3DC). Upregulated (>2.0-fold) and downregulated (<0.5-fold) genes in 3DC compared with 2DC were selected. Pathway analysis using DAVID based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway databases revealed a number of genes involved in glycolysis. In CRC cells, glucose elevated the expression of GLUT1 and AREG as well as the activity of the hypoxia-inducible factor 1 (HIF-1) luciferase reporter promoter. The suppression of AREG expression reduced the uptake of glucose and production of lactate. Luciferase assay identified a critical regulatory region for AREG expression between −130 and −180 bp upstream of the start site, which contained a carbohydrate response element (ChoRE). Max-like protein X (MLX) bound to ChoRE and enhanced the expression of AREG. Together these data suggest that AREG plays a pivotal role in the development of CRC through activation of the Warburg effect

  11. Cancer and Exercise: Warburg Hypothesis, Tumour Metabolism and High-Intensity Anaerobic Exercise.

    Science.gov (United States)

    Hofmann, Peter

    2018-01-31

    There is ample evidence that regular moderate to vigorous aerobic physical activity is related to a reduced risk for various forms of cancer to suggest a causal relationship. Exercise is associated with positive changes in fitness, body composition, and physical functioning as well as in patient-reported outcomes such as fatigue, sleep quality, or health-related quality of life. Emerging evidence indicates that exercise may also be directly linked to the control of tumour biology through direct effects on tumour-intrinsic factors. Beside a multitude of effects of exercise on the human body, one underscored effect of exercise training is to target the specific metabolism of tumour cells, namely the Warburg-type highly glycolytic metabolism. Tumour metabolism as well as the tumour⁻host interaction may be selectively influenced by single bouts as well as regularly applied exercise, dependent on exercise intensity, duration, frequency and mode. High-intensity anaerobic exercise was shown to inhibit glycolysis and some studies in animals showed that effects on tumour growth might be stronger compared with moderate-intensity aerobic exercise. High-intensity exercise was shown to be safe in patients; however, it has to be applied carefully with an individualized prescription of exercise.

  12. Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families.

    Science.gov (United States)

    Chang, Wendy; Winder, Thomas L; LeDuc, Charles A; Simpson, Lynn L; Millar, William S; Dungan, Jeffrey; Ginsberg, Norman; Plaga, Stacey; Moore, Steven A; Chung, Wendy K

    2009-06-01

    Walker-Warburg syndrome (WWS) is a genetically heterogeneous congenital muscular dystrophy caused by abnormal glycosylation of alpha-dystroglycan (alpha-DG) that is associated with brain malformations and eye anomalies. The Fukutin (FKTN) gene, which causes autosomal recessively inherited WWS is most often associated with Fukuyama congenital muscular dystrophy in Japan. We describe the clinical features of four nonconsanguinous Ashkenazi Jewish families with WWS and identify the underlying genetic basis for WWS. We screened for mutations in POMGnT1, POMT1, POMT2, and FKTN, genes causing WWS, by dideoxy sequence analysis. We identified an identical homozygous c.1167insA mutation in the FKTN gene on a common haplotype in all four families and identified 2/299 (0.7%) carriers for the c.1167insA mutation among normal American Ashkenazi Jewish adults. These data suggest that the c.1167insA FKTN mutation described by us is a founder mutation that can be used to target diagnostic testing and carrier screening in the Ashkenazi Jewish population. Copyright (c) 2009 John Wiley & Sons, Ltd.

  13. Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families†

    Science.gov (United States)

    Chang, Wendy; Winder, Thomas L.; LeDuc, Charles A.; Simpson, Lynn L.; Millar, William S.; Dungan, Jeffrey; Ginsberg, Norman; Plaga, Stacey; Moore, Steven A.; Chung, Wendy K.

    2009-01-01

    Objective Walker-Warburg syndrome (WWS) is a genetically heterogeneous congenital muscular dystrophy caused by abnormal glycosylation of α-dystroglycan (α-DG) that is associated with brain malformations and eye anomalies. The Fukutin (FKTN) gene, which causes autosomal recessively inherited WWS is most often associated with Fukuyama congenital muscular dystrophy in Japan. We describe the clinical features of four nonconsanguinous Ashkenazi Jewish families with WWS and identify the underlying genetic basis for WWS. Method We screened for mutations in POMGnT1, POMT1, POMT2, and FKTN, genes causing WWS, by dideoxy sequence analysis. Results We identified an identical homozygous c.1167insA mutation in the FKTN gene on a common haplotype in all four families and identified 2/299 (0.7%) carriers for the c.1167insA mutation among normal American Ashkenazi Jewish adults. Conclusion These data suggest that the c.1167insA FKTN mutation described by us is a founder mutation that can be used to target diagnostic testing and carrier screening in the Ashkenazi Jewish population. PMID:19266496

  14. Optical Coherence Tomography in an Infant with Walker-Warburg Syndrome

    Directory of Open Access Journals (Sweden)

    Natsuko Mano

    2015-06-01

    Full Text Available Purpose: Walker-Warburg syndrome (WWS is a type of congenital muscular dystrophy (CMD characterised by severe brain malformation, lissencephaly, and congenital eye abnormalities. Despite the coexistence of various eye abnormalities, results from optical coherence tomography (OCT in WWS have not previously been reported. We herein report specific OCT findings in an infant with WWS. Patients and Methods: The patient was a 14-day-old boy delivered by caesarean section at 38 weeks and 4 days of gestation and with a birth weight of 2,543 g. A cranial MRI showed lissencephaly, hydrocephalus, an encephalocele, and cerebellar hypoplasia, consistent with the diagnosis of WWS. Results: A bilateral ocular examination showed no abnormalities of the anterior eye segment. A fundus examination showed a persistent hyaloid artery in the vitreous cavity, a widespread loss of fundus pigmentation, transparent choroidal vessels (some choroidal vessel sections were visible, and the absence of a distinct macular reflex. OCT showed no foveal pit and an indistinct laminar structure of the retina. The infant subsequently developed congenital glaucoma and he then died of respiratory failure at the age of 8 months. Conclusions: WWS is associated with a high incidence of congenital eye abnormalities, and this infant showed findings consistent with WWS. OCT revealed a marked retinal dysplasia.

  15. Molecular Pathways: Fumarate Hydratase-Deficient Kidney Cancer: Targeting the Warburg Effect in Cancer

    Science.gov (United States)

    Linehan, W. Marston; Rouault, Tracey A.

    2015-01-01

    Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a hereditary cancer syndrome in which affected individuals are at risk for development of cutaneous and uterine leiomyomas and an aggressive form of type II papillary kidney cancer. HLRCC is characterized by germline mutation of the tricarboxylic acid cycle (TCA) enzyme, fumarate hydratase (FH). FH-deficient kidney cancer is characterized by impaired oxidative phosphorylation and a metabolic shift to aerobic glycolysis, a form of metabolic reprogramming referred to as the Warburg effect. Increased glycolysis generates ATP needed for increased cell proliferation. In FH-deficient kidney cancer levels of AMPK, a cellular energy sensor, are decreased; resulting in diminished p53 levels, decreased expression of the iron importer, DMT1, leading to low cellular iron levels, and to enhanced fatty acid synthesis by diminishing phosphorylation of acetyl CoA carboxylase, a rate limiting step for fatty acid synthesis. Increased fumarate and decreased iron levels in FH-deficient kidney cancer cells inactivate prolyl hydroxylases, leading to stabilization of HIF1α, and increased expression of genes such as vascular endothelial growth factor (VEGF) and GLUT1 to provide fuel needed for rapid growth demands. Several therapeutic approaches for targeting the metabolic basis of FH-deficient kidney cancer are under development or are being evaluated in clinical trials, including the use of agents such as metformin, which would reverse the inactivation of AMPK, approaches to inhibit glucose transport, LDH-A, the anti-oxidant response pathway, the heme oxygenase pathway and approaches to target the tumor vasculature and glucose transport with agents such as bevacizumab and erlotinib. These same types of metabolic shifts, to aerobic glycolysis with decreased oxidative phosphorylation, have been found in a wide variety of other cancer types. Targeting the metabolic basis of a rare cancer such as fumarate hydratase

  16. Brucella abortus Induces a Warburg Shift in Host Metabolism That Is Linked to Enhanced Intracellular Survival of the Pathogen.

    Science.gov (United States)

    Czyż, Daniel M; Willett, Jonathan W; Crosson, Sean

    2017-08-01

    Intracellular bacterial pathogens exploit host cell resources to replicate and survive inside the host. Targeting these host systems is one promising approach to developing novel antimicrobials to treat intracellular infections. We show that human macrophage-like cells infected with Brucella abortus undergo a metabolic shift characterized by attenuated tricarboxylic acid cycle metabolism, reduced amino acid consumption, altered mitochondrial localization, and increased lactate production. This shift to an aerobic glycolytic state resembles the Warburg effect, a change in energy production that is well described in cancer cells and also occurs in activated inflammatory cells. B. abortus efficiently uses lactic acid as its sole carbon and energy source and requires the ability to metabolize lactate for normal survival in human macrophage-like cells. We demonstrate that chemical inhibitors of host glycolysis and lactate production do not affect in vitro growth of B. abortus in axenic culture but decrease its survival in the intracellular niche. Our data support a model in which infection shifts host metabolism to a Warburg-like state, and B. abortus uses this change in metabolism to promote intracellular survival. Pharmacological perturbation of these features of host cell metabolism may be a useful strategy to inhibit infection by intracellular pathogens. IMPORTANCE Brucella spp. are intracellular bacterial pathogens that cause disease in a range of mammals, including livestock. Transmission from livestock to humans is common and can lead to chronic human disease. Human macrophage-like cells infected with Brucella abortus undergo a Warburg-like metabolic shift to an aerobic glycolytic state where the host cells produce lactic acid and have reduced amino acid catabolism. We provide evidence that the pathogen can exploit this change in host metabolism to support growth and survival in the intracellular niche. Drugs that inhibit this shift in host cell metabolism

  17. A vida póstuma de Aby Warburg: por que seu pensamento seduz os pesquisadores contemporâneos da imagem?

    Directory of Open Access Journals (Sweden)

    Mauricio Lissovsky

    Full Text Available A fama de Aby Warburg (1866-1929 sempre superou o conhecimento de sua obra. Mas, nas últimas duas décadas, alguns dos mais importantes pensadores da estética - como Georges Didi-Huberman e Giorgio Agamben - encontram neste obscuro historiador da arte alemão um precursor de suas próprias investigações. Partindo do debate sobre o legado de Warburg nas obras de Ernst Gombrich e Erwin Panofsky, este ensaio procura historiar a trajetória deste resgate e repertoriar os conceitos e procedimentos warburgianos que mais mobilizam os teóricos contemporâneos. Sugere-se, por fim, que é devido à crescente influência de Walter Benjamin e às inquietações suscitadas pelo estatuto da imagem na contemporaneidade que os estudos de Warburg voltam a servir de referência para historiadores e estudiosos da imagem.

  18. Measurement of the antineutrino to neutrino charged-current interaction cross section ratio in MINERvA

    Science.gov (United States)

    Ren, L.; Aliaga, L.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Budd, H.; Cai, T.; Carneiro, M. F.; da Motta, H.; Devan, J.; Dytman, S. A.; Díaz, G. A.; Eberly, B.; Endress, E.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Gallagher, H.; Ghosh, A.; Golan, T.; Gran, R.; Han, J. Y.; Harris, D. A.; Hurtado, K.; Kiveni, M.; Kleykamp, J.; Kordosky, M.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Marshall, C. M.; Martinez Caicedo, D. A.; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Mousseau, J.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman, Paolone, V.; Park, J.; Patrick, C. E.; Perdue, G. N.; Ramírez, M. A.; Ransome, R. D.; Ray, H.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schellman, H.; Solano Salinas, C. J.; Sultana, M.; Sánchez Falero, S.; Valencia, E.; Walton, T.; Wolcott, J.; Wospakrik, M.; Yaeggy, B.; MinerνA Collaboration

    2017-04-01

    We present measurements of the neutrino and antineutrino total charged-current cross sections on carbon and their ratio using the MINERvA scintillator-tracker. The measurements span the energy range 2-22 GeV and were performed using forward and reversed horn focusing modes of the Fermilab low-energy NuMI beam to obtain large neutrino and antineutrino samples. The flux is obtained using a subsample of charged-current events at low hadronic energy transfer along with precise higher energy external neutrino cross section data overlapping with our energy range between 12-22 GeV. We also report on the antineutrino-neutrino cross section ratio, RCC , which does not rely on external normalization information. Our ratio measurement, obtained within the same experiment using the same technique, benefits from the cancellation of common sample systematic uncertainties and reaches a precision of ˜5 % at low energy. Our results for the antineutrino-nucleus scattering cross section and for RCC are the most precise to date in the energy range Eν<6 GeV .

  19. Measurement of the Antineutrino Double-Differential Charged-Current Quasi-Elastic Scattering Cross Section at MINERvA

    Energy Technology Data Exchange (ETDEWEB)

    Patrick, Cheryl [Northwestern U.

    2016-01-01

    Next-generation neutrino oscillation experiments, such as DUNE and Hyper-Kamiokande, hope to measure charge-parity (CP) violation in the lepton sector. In order to do this, they must dramatically reduce their current levels of uncertainty, particularly those due to neutrino-nucleus interaction models. As CP violation is a measure of the difference between the oscillation properties of neutrinos and antineutrinos, data about how the less-studied antineutrinos interact is especially valuable. We present the MINERvA experiment's first double-differential scattering cross sections for antineutrinos on scintillator, in the few-GeV range relevant to experiments such as DUNE and NOvA. We also present total antineutrino-scintillator quasi-elastic cross sections as a function of energy, which we compare to measurements from previous experiments. As well as being useful to help reduce oscillation experiments' uncertainty, our data can also be used to study the prevalence of various cor relation and final-state interaction effects within the nucleus. We compare to models produced by different model generators, and are able to draw first conclusions about the predictions of these models.

  20. Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK and FOXO1.

    Directory of Open Access Journals (Sweden)

    Tamás Fodor

    Full Text Available Cancer cells are characterized by metabolic alterations, namely, depressed mitochondrial oxidation, enhanced glycolysis and pentose phosphate shunt flux to support rapid cell growth, which is called the Warburg effect. In our study we assessed the metabolic consequences of a joint treatment of MCF-7 breast cancer cells with AICAR, an inducer of AMP-activated kinase (AMPK jointly with methotrexate (MTX, a folate-analog antimetabolite that blunts de novo nucleotide synthesis. MCF7 cells, a model of breast cancer cells, were resistant to the individual application of AICAR or MTX, however combined treatment of AICAR and MTX reduced cell proliferation. Prolonged joint application of AICAR and MTX induced AMPK and consequently enhanced mitochondrial oxidation and reduced the rate of glycolysis. These metabolic changes suggest an anti-Warburg rearrangement of metabolism that led to the block of the G1/S and the G2/M transition slowing down cell cycle. The slowdown of cell proliferation was abolished when mitotropic transcription factors, PGC-1α, PGC-1β or FOXO1 were silenced. In human breast cancers higher expression of AMPKα and FOXO1 extended survival. AICAR and MTX exerts similar additive antiproliferative effect on other breast cancer cell lines, such as SKBR and 4T1 cells, too. Our data not only underline the importance of Warburg metabolism in breast cancer cells but nominate the AICAR+MTX combination as a potential cytostatic regime blunting Warburg metabolism. Furthermore, we suggest the targeting of AMPK and FOXO1 to combat breast cancer.

  1. Laminin beta 2 chain and adhalin deficiency in the skeletal muscle of Walker-Warburg syndrome (cerebro-ocular dysplasia-muscular dystrophy)

    DEFF Research Database (Denmark)

    Wewer, U M; Durkin, M E; Zhang, X

    1995-01-01

    Muscular dystrophy may be caused by disturbances in a number of muscle proteins that appear to be part of a chain of interacting molecules that includes cytoskeletal, cell membrane, and basement membrane components. We found that the skeletal muscle cells in two cases of Walker-Warburg syndrome w...

  2. Transforming growth factor-β induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis.

    Science.gov (United States)

    Young, Vicky J; Brown, Jeremy K; Maybin, Jacqueline; Saunders, Philippa T K; Duncan, W Colin; Horne, Andrew W

    2014-09-01

    TGF-β is believed to play a major role in the etiology of peritoneal endometriosis. In tumors, TGF-β induces the metabolic conversion of glucose to lactate via glycolysis, a process referred to as the "Warburg effect." Lactate increases cell invasion, angiogenesis, and immune suppression, all crucial steps in the development of endometriosis. The aim of this study was to determine whether TGF-β induces a "Warburg-like" effect in peritoneal endometriosis. The study was informed by human tissue analysis and cel culture. The study was conducted at the university research institute. We studied women undergoing surgical investigation for endometriosis. Concentrations of lactate and TGF-β1 in peritoneal fluid (n = 16) were measured by commercial assay. Expression of genes implicated in glycolysis was measured in endometrial and peritoneal biopsies (n = 31) by quantitative RT-PCR and immunohistochemistry. The effect of TGF-β1 on primary human peritoneal mesothelial cells (n = 6) and immortalized mesothelial (MeT-5A) cells (n = 3) was assessed by quantitative RT-PCR, Western blot, and commercial assays. Lactate, TGF-β1, and markers of glycolysis were measured. Concentrations of lactate in peritoneal fluid paralleled those of TGF-β1, being significantly higher in women with endometriosis compared to women without (P Endometriosis lesions expressed higher levels of glycolysis-associated genes HIF1A, PDK1, and LDHA than eutopic endometrium, and adjacent peritoneum had higher levels of HIF1A and SLC2A1 than peritoneum from women without disease (P endometriosis lesions and peritoneal mesothelium in women with endometriosis may favor development of endometriosis.

  3. Flux balance analysis predicts Warburg-like effects of mouse hepatocyte deficient in miR-122a.

    Directory of Open Access Journals (Sweden)

    Hua-Qing Wu

    2017-07-01

    Full Text Available The liver is a vital organ involving in various major metabolic functions in human body. MicroRNA-122 (miR-122 plays an important role in the regulation of liver metabolism, but its intrinsic physiological functions require further clarification. This study integrated the genome-scale metabolic model of hepatocytes and mouse experimental data with germline deletion of Mir122a (Mir122a-/- to infer Warburg-like effects. Elevated expression of MiR-122a target genes in Mir122a-/-mice, especially those encoding for metabolic enzymes, was applied to analyze the flux distributions of the genome-scale metabolic model in normal and deficient states. By definition of the similarity ratio, we compared the flux fold change of the genome-scale metabolic model computational results and metabolomic profiling data measured through a liquid-chromatography with mass spectrometer, respectively, for hepatocytes of 2-month-old mice in normal and deficient states. The Ddc gene demonstrated the highest similarity ratio of 95% to the biological hypothesis of the Warburg effect, and similarity of 75% to the experimental observation. We also used 2, 6, and 11 months of mir-122 knockout mice liver cell to examined the expression pattern of DDC in the knockout mice livers to show upregulated profiles of DDC from the data. Furthermore, through a bioinformatics (LINCS program prediction, BTK inhibitors and withaferin A could downregulate DDC expression, suggesting that such drugs could potentially alter the early events of metabolomics of liver cancer cells.

  4. III. Cellular ultrastructures in situ as key to understanding tumor energy metabolism: biological significance of the Warburg effect.

    Science.gov (United States)

    Witkiewicz, Halina; Oh, Phil; Schnitzer, Jan E

    2013-01-01

    Despite the universality of metabolic pathways, malignant cells were found to have their metabolism reprogrammed to generate energy by glycolysis even under normal oxygen concentrations (the Warburg effect). Therefore, the pathway energetically 18 times less efficient than oxidative phosphorylation was implicated to match increased energy requirements of growing tumors. The paradox was explained by an abnormally high rate of glucose uptake, assuming unlimited availability of substrates for tumor growth in vivo. However, ultrastructural analysis of tumor vasculature morphogenesis showed that the growing tissue regions did not have continuous blood supply and intermittently depended on autophagy for survival. Erythrogenic autophagy, and resulting ATP generation by glycolysis, appeared critical to initiating vasculature formation where it was missing. This study focused on ultrastructural features that reflected metabolic switch from aerobic to anaerobic. Morphological differences between and within different types of cells were evident in tissue sections. In cells undergoing nucleo-cytoplasmic conversion into erythrosomes (erythrogenesis), gradual changes led to replacing mitochondria with peroxisomes, through an intermediate form connected to endoplasmic reticulum. Those findings related to the issue of peroxisome biogenesis and to the phenomenon of hemogenic endothelium. Mitochondria were compacted also during mitosis. In vivo, cells that lost and others that retained capability to use oxygen coexisted side-by-side; both types were important for vasculature morphogenesis and tissue growth. Once passable, the new vasculature segment could deliver external oxygen and nutrients. Nutritional and redox status of microenvironment had similar effect on metabolism of malignant and non-malignant cells demonstrating the necessity to maintain structure-energy equivalence in all living cells. The role of glycolysis in initiating vasculature formation, and in progression of

  5. Measurement of νμ charged-current single π0 production on hydrocarbon in the few-GeV region using MINERvA

    Science.gov (United States)

    Altinok, O.; Le, T.; Aliaga, L.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Budd, H.; Caceres Vera, G. F. R.; Cai, T.; Carneiro, M. F.; da Motta, H.; Dytman, S. A.; Díaz, G. A.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Gallagher, H.; Ghosh, A.; Gran, R.; Han, J. Y.; Harris, D. A.; Kleykamp, J.; Kordosky, M.; Maher, E.; Manly, S.; Mann, W. A.; Marshall, C. M.; Martinez Caicedo, D. A.; McFarland, K. S.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman, Paolone, V.; Patrick, C. E.; Perdue, G. N.; Ramirez, M. A.; Ransome, R. D.; Ray, H.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schellman, H.; Sobczyk, J. T.; Solano Salinas, C. J.; Sultana, M.; Sánchez Falero, S.; Valencia, E.; Wolcott, J.; Yaeggy, B.

    2017-10-01

    The semiexclusive channel νμ+CH →μ-π0+nucleon(s ) is analyzed using MINERvA exposed to the low-energy NuMI νμ beam with spectral peak at Eν≃3 GeV . Differential cross sections for muon momentum and production angle, π0 kinetic energy and production angle, and for squared four-momentum transfer are reported, and the cross section σ (Eν) is obtained over the range 1.5 GeV ≤Eν<20 GeV . Results are compared to GENIE and NuWro predictions and to published MINERvA cross sections for charged-current π+(π0) production by νμ(ν¯μ) neutrinos. Disagreements between data and simulation are observed at very low and relatively high values for muon angle and for Q2 that may reflect shortfalls in modeling of interactions on carbon. For π0 kinematic distributions, however, the data are consistent with the simulation and provide support for generator treatments of pion intranuclear scattering. Using signal-event subsamples that have reconstructed protons as well as π0 mesons, the p π0 invariant mass distribution is obtained, and the decay polar and azimuthal angle distributions in the rest frame of the p π0 system are measured in the region of Δ (1232 )+ production, W <1.4 GeV .

  6. The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

    Directory of Open Access Journals (Sweden)

    Paweł Lis

    2016-12-01

    Full Text Available This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the “Warburg” and “Crabtree” effects. This work also summarizes two key discoveries, one of which relates to hexokinase-2 (HK2, a major player in both the “Warburg effect” and cancer cell immortalization. The second discovery relates to the finding that cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the “Warburg effect”, and the remaining 40% is derived from mitochondrial oxidative phosphorylation. Also described are selected anticancer agents which generally act as strong energy blockers inside cancer cells. Among them, much attention has focused on 3-bromopyruvate (3BP. This small alkylating compound targets both the “Warburg effect”, i.e., elevated glycolysis even in the presence oxygen, as well as mitochondrial oxidative phosphorylation in cancer cells. Normal cells remain unharmed. 3BP rapidly kills cancer cells growing in tissue culture, eradicates tumors in animals, and prevents metastasis. In addition, properly formulated 3BP shows promise also as an effective anti-liver cancer agent in humans and is effective also toward cancers known as “multiple myeloma”. Finally, 3BP has been shown to significantly extend the life of a human patient for which no other options were available. Thus, it can be stated that 3BP is a very promising new anti-cancer agent in the process of undergoing clinical development.

  7. Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

    Directory of Open Access Journals (Sweden)

    Jeff Charles Kremer

    2017-01-01

    Full Text Available Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1 is a common metabolic alteration reported in a broad range of aggressive cancers. To assess the metabolic effects that arise from acute and chronic arginine starvation in ASS1-deficient cell lines, we performed metabolite profiling. We found that pharmacologically induced arginine depletion causes increased serine biosynthesis, glutamine anaplerosis, oxidative phosphorylation, and decreased aerobic glycolysis, effectively inhibiting the Warburg effect. The reduction of glycolysis in cells otherwise dependent on aerobic glycolysis is correlated with reduced PKM2 expression and phosphorylation and upregulation of PHGDH. Concurrent arginine deprivation and glutaminase inhibition was found to be synthetic lethal across a spectrum of ASS1-deficient tumor cell lines and is sufficient to cause in vivo tumor regression in mice. These results identify two synthetic lethal therapeutic strategies exploiting metabolic vulnerabilities of ASS1-negative cancers.

  8. Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology.

    Directory of Open Access Journals (Sweden)

    Alexei Vazquez

    2011-04-01

    Full Text Available Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is unknown. To study this issue, here we develop a model of human central metabolism that incorporates a solvent capacity constraint of metabolic enzymes and mitochondria, accounting for their occupied volume densities, while assuming glucose and/or fatty acid utilization. The model demonstrates that activation of aerobic glycolysis is favored above a threshold metabolic rate in both rapidly proliferating cells and heavily contracting muscles, because it provides higher ATP yield per volume density than mitochondrial oxidative phosphorylation. In the case of muscle physiology, the model also predicts that before the lactate switch, fatty acid oxidation increases, reaches a maximum, and then decreases to zero with concomitant increase in glucose utilization, in agreement with the empirical evidence. These results are further corroborated by a larger scale model, including biosynthesis of major cell biomass components. The larger scale model also predicts that in proliferating cells the lactate switch is accompanied by activation of glutaminolysis, another distinctive feature of the Warburg effect. In conclusion, intracellular molecular crowding is a fundamental constraint for cell metabolism in both rapidly proliferating- and non-proliferating cells with high metabolic demand. Addition of this constraint to metabolic flux balance models can explain several observations of mammalian cell metabolism under steady state conditions.

  9. HK2 Recruitment to Phospho-BAD Prevents Its Degradation, Promoting Warburg Glycolysis by Theileria-Transformed Leukocytes.

    Science.gov (United States)

    Haidar, Malak; Lombès, Anne; Bouillaud, Frédéric; Kennedy, Eileen J; Langsley, Gordon

    2017-03-10

    Theileria annulata infects bovine leukocytes, transforming them into invasive, cancer-like cells that cause the widespread disease called tropical theileriosis. We report that in Theileria-transformed leukocytes hexokinase-2 (HK2) binds to B cell lymphoma-2-associated death promoter (BAD) only when serine (S) 155 in BAD is phosphorylated. We show that HK2 recruitment to BAD is abolished by a cell-penetrating peptide that acts as a nonphosphorylatable BAD substrate that inhibits endogenous S155 phosphorylation, leading to complex dissociation and ubiquitination and degradation of HK2 by the proteasome. As HK2 is a critical enzyme involved in Warburg glycolysis, its loss forces Theileria-transformed macrophages to switch back to HK1-dependent oxidative glycolysis that down-regulates macrophage proliferation only when they are growing on glucose. When growing on galactose, degradation of HK2 has no effect on Theileria-infected leukocyte proliferation, because metabolism of this sugar is independent of hexokinases. Thus, targeted disruption of the phosphorylation-dependent HK2/BAD complex may represent a novel approach to control Theileria-transformed leukocyte proliferation.

  10. Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH.

    Science.gov (United States)

    Schwartz, Laurent; Seyfried, Thomas; Alfarouk, Khalid O; Da Veiga Moreira, Jorgelindo; Fais, Stefano

    2017-04-01

    As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketogenic diet). To increase catabolism, the oxidative phosphorylation should be restored. Treatment with a combination of α-lipoic acid and hydroxycitrate has been shown to be effective in multiple animal models. This treatment, in combination with conventional chemotherapy, has yielded extremely encouraging results in glioblastoma, brain metastasis and lung cancer. Randomized trials are necessary to confirm these preliminary data. The major limitation is the fact that the combination of α-lipoic acid and hydroxycitrate can only be effective if the mitochondria are still present and/or functional. That may not be the case in the most aggressive tumors. The increased intracellular alkalosis is a strong mitogenic signal, which bypasses most inhibitory signals. Concomitant correction of this alkalosis may be a very effective treatment in case of mitochondrial failure. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-γ

    Science.gov (United States)

    Appelberg, Rui; Moreira, Diana; Barreira-Silva, Palmira; Borges, Margarida; Silva, Letícia; Dinis-Oliveira, Ricardo Jorge; Resende, Mariana; Correia-Neves, Margarida; Jordan, Michael B; Ferreira, Nuno C; Abrunhosa, Antero J; Silvestre, Ricardo

    2015-01-01

    Granulomas are the hallmark of mycobacterial disease. Here, we demonstrate that both the cell recruitment and the increased glucose consumption in granulomatous infiltrates during Mycobacterium avium infection are highly dependent on interferon-γ (IFN-γ). Mycobacterium avium-infected mice lacking IFN-γ signalling failed to developed significant inflammatory infiltrations and lacked the characteristic uptake of the glucose analogue fluorine-18-fluorodeoxyglucose (FDG). To assess the role of macrophages in glucose uptake we infected mice with a selective impairment of IFN-γ signalling in the macrophage lineage (MIIG mice). Although only a partial reduction of the granulomatous areas was observed in infected MIIG mice, the insensitivity of macrophages to IFN-γ reduced the accumulation of FDG. In vivo, ex vivo and in vitro assays showed that macrophage activated by IFN-γ displayed increased rates of glucose uptake and in vitro studies showed also that they had increased lactate production and increased expression of key glycolytic enzymes. Overall, our results show that the activation of macrophages by IFN-γ is responsible for the Warburg effect observed in organs infected with M. avium. PMID:25807843

  12. Targeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells

    Science.gov (United States)

    Lai, I-Lu; Chou, Chih-Chien; Lai, Po-Ting; Fang, Chun-Sheng; Shirley, Lawrence A.; Yan, Ribai; Mo, Xiaokui; Bloomston, Mark; Kulp, Samuel K.; Bekaii-Saab, Tanios; Chen, Ching-Shih

    2014-01-01

    Gemcitabine resistance remains a significant clinical challenge. Here, we used a novel glucose transporter (Glut) inhibitor, CG-5, as a proof-of-concept compound to investigate the therapeutic utility of targeting the Warburg effect to overcome gemcitabine resistance in pancreatic cancer. The effects of gemcitabine and/or CG-5 on viability, survival, glucose uptake and DNA damage were evaluated in gemcitabine-sensitive and gemcitabine-resistant pancreatic cancer cell lines. Mechanistic studies were conducted to determine the molecular basis of gemcitabine resistance and the mechanism of CG-5-induced sensitization to gemcitabine. The effects of CG-5 on gemcitabine sensitivity were investigated in a xenograft tumor model of gemcitabine-resistant pancreatic cancer. In contrast to gemcitabine-sensitive pancreatic cancer cells, the resistant Panc-1 and Panc-1GemR cells responded to gemcitabine by increasing the expression of ribonucleotide reductase M2 catalytic subunit (RRM2) through E2F1-mediated transcriptional activation. Acting as a pan-Glut inhibitor, CG-5 abrogated this gemcitabine-induced upregulation of RRM2 through decreased E2F1 expression, thereby enhancing gemcitabine-induced DNA damage and inhibition of cell survival. This CG-5-induced inhibition of E2F1 expression was mediated by the induction of a previously unreported E2F1-targeted microRNA, miR-520f. The addition of oral CG-5 to gemcitabine therapy caused greater suppression of Panc-1GemR xenograft tumor growth in vivo than either drug alone. Glut inhibition may be an effective strategy to enhance gemcitabine activity for the treatment of pancreatic cancer. PMID:24879635

  13. NMR (1H and 13C) based signatures of abnormal choline metabolism in oral squamous cell carcinoma with no prominent Warburg effect

    International Nuclear Information System (INIS)

    Bag, Swarnendu; Banerjee, Deb Ranjan; Basak, Amit; Das, Amit Kumar; Pal, Mousumi; Banerjee, Rita; Paul, Ranjan Rashmi; Chatterjee, Jyotirmoy

    2015-01-01

    At functional levels, besides genes and proteins, changes in metabolome profiles are instructive for a biological system in health and disease including malignancy. It is understood that metabolomic alterations in association with proteomic and transcriptomic aberrations are very fundamental to unravel malignant micro-ambient criticality and oral cancer is no exception. Hence deciphering intricate dimensions of oral cancer metabolism may be contributory both for integrated appreciation of its pathogenesis and to identify any critical but yet unexplored dimension of this malignancy with high mortality rate. Although several methods do exist, NMR provides higher analytical precision in identification of cancer metabolomic signature. Present study explored abnormal signatures in choline metabolism in oral squamous cell carcinoma (OSCC) using 1 H and 13 C NMR analysis of serum. It has demonstrated down-regulation of choline with concomitant up-regulation of its break-down product in the form of trimethylamine N-oxide in OSCC compared to normal counterpart. Further, no significant change in lactate profile in OSCC possibly indicated that well-known Warburg effect was not a prominent phenomenon in such malignancy. Amongst other important metabolites, malonate has shown up-regulation but D-glucose, saturated fatty acids, acetate and threonine did not show any significant change. Analyzing these metabolomic findings present study proposed trimethyl amine N-oxide and malonate as important metabolic signature for oral cancer with no prominent Warburg effect. - Highlights: • NMR ( 1 H and 13 C) study of Oral Squamous cell Carcinoma Serum. • Abnormal Choline metabolomic signatures. • Up-regulation of Trimethylamine N-oxide. • Unchanged lactate profile indicates no prominent Warburg effect. • Proposed alternative glucose metabolism path through up-regulation of malonate

  14. Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

    Directory of Open Access Journals (Sweden)

    Pluk Helma

    2009-07-01

    Full Text Available Abstract Background The Warburg phenotype in cancer cells has been long recognized, but there is still limited insight in the consecutive metabolic alterations that characterize its establishment. We obtained better understanding of the coupling between metabolism and malignant transformation by studying mouse embryonic fibroblast-derived cells with loss-of-senescence or H-RasV12/E1A-transformed phenotypes at different stages of oncogenic progression. Results Spontaneous immortalization or induction of senescence-bypass had only marginal effects on metabolic profiles and viability. In contrast, H-RasV12/E1A transformation initially caused a steep increase in oxygen consumption and superoxide production, accompanied by massive cell death. During prolonged culture in vitro, cell growth rate increased gradually, along with tumor forming potential in in vitro anchorage-independent growth assays and in vivo tumor formation assays in immuno-deficient mice. Notably, glucose-to-lactic acid flux increased with passage number, while cellular oxygen consumption decreased. This conversion in metabolic properties was associated with a change in mitochondrial NAD+/NADH redox, indicative of decreased mitochondrial tricarboxic acid cycle and OXPHOS activity. Conclusion The high rate of oxidative metabolism in newly transformed cells is in marked contrast with the high glycolytic rate in cells in the later tumor stage. In our experimental system, with cells growing under ambient oxygen conditions in nutrient-rich media, the shift towards this Warburg phenotype occurred as a step-wise adaptation process associated with augmented tumorigenic capacity and improved survival characteristics of the transformed cells. We hypothesize that early-transformed cells, which potentially serve as founders for new tumor masses may escape therapies aimed at metabolic inhibition of tumors with a fully developed Warburg phenotype.

  15. NMR ({sup 1}H and {sup 13}C) based signatures of abnormal choline metabolism in oral squamous cell carcinoma with no prominent Warburg effect

    Energy Technology Data Exchange (ETDEWEB)

    Bag, Swarnendu, E-mail: Swarna.bag@gmail.com [School of Medical Science and Technology, Indian Institute of Technology-Kharagpur, 721302 West Bengal (India); Banerjee, Deb Ranjan, E-mail: debranjan2@gmail.com [Department of Chemistry, Indian Institute of Technology-Kharagpur, 721302 West Bengal (India); Basak, Amit, E-mail: absk@chem.iitkgp.ernet.in [Department of Chemistry, Indian Institute of Technology-Kharagpur, 721302 West Bengal (India); Das, Amit Kumar, E-mail: amitk@hijli.iitkgp.ernet.in [Department of Biotechnology, Indian Institute of Technology-Kharagpur, 721302 West Bengal (India); Pal, Mousumi, E-mail: drmpal62@gmail.com [Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal (India); Banerjee, Rita, E-mail: ritabanerjee@outlook.com [Department of Science and Technology, New Mehrauli Road, New Delhi 110016 (India); Paul, Ranjan Rashmi, E-mail: dr_rsspaul@yahoo.co.in [Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal (India); Chatterjee, Jyotirmoy, E-mail: jchatterjee.iitkgp@gmail.com [School of Medical Science and Technology, Indian Institute of Technology-Kharagpur, 721302 West Bengal (India)

    2015-04-17

    At functional levels, besides genes and proteins, changes in metabolome profiles are instructive for a biological system in health and disease including malignancy. It is understood that metabolomic alterations in association with proteomic and transcriptomic aberrations are very fundamental to unravel malignant micro-ambient criticality and oral cancer is no exception. Hence deciphering intricate dimensions of oral cancer metabolism may be contributory both for integrated appreciation of its pathogenesis and to identify any critical but yet unexplored dimension of this malignancy with high mortality rate. Although several methods do exist, NMR provides higher analytical precision in identification of cancer metabolomic signature. Present study explored abnormal signatures in choline metabolism in oral squamous cell carcinoma (OSCC) using {sup 1}H and {sup 13}C NMR analysis of serum. It has demonstrated down-regulation of choline with concomitant up-regulation of its break-down product in the form of trimethylamine N-oxide in OSCC compared to normal counterpart. Further, no significant change in lactate profile in OSCC possibly indicated that well-known Warburg effect was not a prominent phenomenon in such malignancy. Amongst other important metabolites, malonate has shown up-regulation but D-glucose, saturated fatty acids, acetate and threonine did not show any significant change. Analyzing these metabolomic findings present study proposed trimethyl amine N-oxide and malonate as important metabolic signature for oral cancer with no prominent Warburg effect. - Highlights: • NMR ({sup 1}H and {sup 13}C) study of Oral Squamous cell Carcinoma Serum. • Abnormal Choline metabolomic signatures. • Up-regulation of Trimethylamine N-oxide. • Unchanged lactate profile indicates no prominent Warburg effect. • Proposed alternative glucose metabolism path through up-regulation of malonate.

  16. «…la fatica di ricostruire la naturale unità fra parola e immagine». Warburg, Benjamin e ciò che la storia non può dire

    Directory of Open Access Journals (Sweden)

    Silvia Ferretti

    2012-05-01

    Full Text Available The paper intends to draw some topics about relationship between word and image in works and thinking of Aby Warburg and Walter Benjamin. In recent history of ideas, word and image are frequently interpreted as alternative ways to express reality. In both, Warburg and Benjamin, and in spite of  their very different methods of approaching history of art and history of culture, we can find a similar idea of the connection between word and image. The two authors deem that this relationship is necessary to understand historical facts and legacy.

  17. Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect

    Directory of Open Access Journals (Sweden)

    Thomas Sithara

    2017-09-01

    Full Text Available The study under investigation focuses on in vitro antiproliferative efficacy of the flavonoid morin and the mechanisms by which it inhibits the growth of colon cancer using SW480 colon cancer cells with emphasis on Warburg effect. It was found that the cell proliferation was significantly inhibited by morin in a dose and time dependent manner. Morin induced apoptosis that was correlated with increased levels of reactive oxygen species formation and loss of mitochondrial membrane potential of the cells. In addition, an increase in cleaved PARP, cleaved caspase 3, cleaved caspase 8, cleaved caspase 9 and Bax as well as a decrease in Bcl 2 was observed, indicating morin is inducing both intrinsic as well as extrinsic pathway of apoptosis. This was further confirmed by using downstream caspase 3 inhibitor which indicated that caspase 3 inhibition reduces morin induced cell death. Moreover, the impact of morin on over all energy status when determined in terms of total cellular ATP level showed a decline with low level of glucose uptake and Glut1 expression. The results indicate that morin exerts antiproliferative activity by inducing apoptosis and by reducing Warburg effect in the evaluated cell lines and provide preliminary evidence for its anticancer activity.

  18. The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes

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    Fan Xing

    2017-01-01

    Full Text Available Summary: Glioblastoma multiforme (GBM is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we established an induced differentiation model of GBM using cAMP activators that specifically directed GBM differentiation into astroglia. Transcriptomic and proteomic analyses revealed that oxidative phosphorylation and mitochondrial biogenesis are involved in induced differentiation of GBM. Dibutyryl cyclic AMP (dbcAMP reverses the Warburg effect, as evidenced by increased oxygen consumption and reduced lactate production. Mitochondrial biogenesis induced by activation of the CREB-PGC1α pathway triggers metabolic shift and differentiation. Blocking mitochondrial biogenesis using mdivi1 or by silencing PGC1α abrogates differentiation; conversely, overexpression of PGC1α elicits differentiation. In GBM xenograft models and patient-derived GBM samples, cAMP activators also induce tumor growth inhibition and differentiation. Our data show that mitochondrial biogenesis and metabolic switch to oxidative phosphorylation drive the differentiation of tumor cells. : Xing et al. show that the metabolic shift from glycolysis to oxidative phosphorylation drives differentiation of GBM cells into astrocytes by cAMP activation. Mechanistically, the cAMP-CREB-PGC1α signal mediates mitochondrial biogenesis, which leads to metabolic reprogramming, induced differentiation, and tumor growth inhibition. Keywords: glioblastoma, induced differentiation, Warburg effect, metabolic reprogramming, oxidative phosphorylation, glycolysis, mitochondrial biogenesis, cyclic adenosine monophosphate, cAMP, PPARγ coactivator-1α, PGC1α

  19. Light exposure at night disrupts host/cancer circadian regulatory dynamics: impact on the Warburg effect, lipid signaling and tumor growth prevention.

    Directory of Open Access Journals (Sweden)

    David E Blask

    Full Text Available The central circadian clock within the suprachiasmatic nucleus (SCN plays an important role in temporally organizing and coordinating many of the processes governing cancer cell proliferation and tumor growth in synchrony with the daily light/dark cycle which may contribute to endogenous cancer prevention. Bioenergetic substrates and molecular intermediates required for building tumor biomass each day are derived from both aerobic glycolysis (Warburg effect and lipid metabolism. Using tissue-isolated human breast cancer xenografts grown in nude rats, we determined that circulating systemic factors in the host and the Warburg effect, linoleic acid uptake/metabolism and growth signaling activities in the tumor are dynamically regulated, coordinated and integrated within circadian time structure over a 24-hour light/dark cycle by SCN-driven nocturnal pineal production of the anticancer hormone melatonin. Dim light at night (LAN-induced melatonin suppression disrupts this circadian-regulated host/cancer balance among several important cancer preventative signaling mechanisms, leading to hyperglycemia and hyperinsulinemia in the host and runaway aerobic glycolysis, lipid signaling and proliferative activity in the tumor.

  20. Warburg effect's manifestation in aggressive pheochromocytomas and paragangliomas: insights from a mouse cell model applied to human tumor tissue.

    Directory of Open Access Journals (Sweden)

    Stephanie M J Fliedner

    Full Text Available A glycolytic profile unifies a group of pheochromocytomas and paragangliomas (PHEOs/PGLs with distinct underlying gene defects, including von Hippel-Lindau (VHL and succinate dehydrogenase B (SDHB mutations. Nevertheless, their tumor aggressiveness is distinct: PHEOs/PGLs metastasize rarely in VHL-, but frequently in SDHB-patients. To date, the molecular mechanisms causing the more aggressive phenotype in SDHB-PHEOs/PGLs remain largely unknown. Recently, however, an excellent model to study aggressive PHEOs (mouse tumor tissue (MTT cells has been developed from mouse PHEO cells (MPC. We employed this model for a proteomics based approach to identify changes characteristic for tumor aggressiveness, which we then explored in a homogeneous set of human SDHB- and VHL-PHEOs/PGLs. The increase of glucose transporter 1 in VHL, and of hexokinase 2 in VHL and SDHB, confirmed their glycolytic profile. In agreement with the cell model and in support of decoupling of glycolysis, the Krebs cycle and oxidative phosphorylation (OXPHOS, SDHB tumors showed increased lactate dehydrogenase levels. In SDHB-PGLs OXPHOS complex activity was increased at complex III and, as expected, decreased at complex II. Moreover, protein and mRNA expression of all tested OXPHOS-related genes were higher in SDHB- than in VHL-derived tumors. Although there was no direct evidence for increased reactive oxygen species production, elevated superoxide dismutase 2 expression may reflect elevated oxidative stress in SDHB-derived PHEOs/PGLs. For the first time, we show that despite dysfunction in complex II and evidence for a glycolytic phenotype, the Warburg effect does not seem to fully apply to SDHB-PHEOs/PGLs with respect to decreased OXPHOS. In addition, we present evidence for increased LDHA and SOD2 expression in SDHB-PHEOs/PGLs, proteins that have been proposed as promising therapeutic targets in other cancers. This study provides new insight into pathogenic mechanisms in

  1. Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy☆

    Science.gov (United States)

    Mathupala, Saroj P.; Ko, Young H.; Pedersen, Peter L.

    2009-01-01

    The most common metabolic hallmark of malignant tumors, i.e., the “Warburg effect” is their propensity to metabolize glucose to lactic acid at a high rate even in the presence of oxygen. The pivotal player in this frequent cancer phenotype is mitochondrial-bound hexokinase [Bustamante E, Pedersen PL. High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Natl Acad Sci USA 1977;74(9):3735−9; Bustamante E, Morris HP, Pedersen PL. Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 1981;256(16):8699−704]. Now, in clinics worldwide this prominent phenotype forms the basis of one of the most common detection systems for cancer, i.e., positron emission tomography (PET). Significantly, HK-2 is the major bound hexokinase isoform expressed in cancers that exhibit a “Warburg effect”. This includes most cancers that metastasize and kill their human host. By stationing itself on the outer mitochondrial membrane, HK-2 also helps immortalize cancer cells, escapes product inhibition and gains preferential access to newly synthesized ATP for phosphorylating glucose. The latter event traps this essential nutrient inside the tumor cells as glucose-6-P, some of which is funneled off to serve as carbon precursors to help promote the production of new cancer cells while much is converted to lactic acid that exits the cells. The resultant acidity likely wards off an immune response while preparing surrounding tissues for invasion. With the re-emergence and acceptance of both the “Warburg effect” as a prominent phenotype of most clinical cancers, and “metabolic targeting” as a rational therapeutic strategy, a number of laboratories are focusing on metabolite entry or exit steps. One remarkable success story [Ko YH, Smith BL, Wang Y, Pomper MG, Rini DA, Torbenson MS, et al. Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to

  2. 2-Deoxyglucose induces the expression of thioredoxin interacting protein (TXNIP) by increasing O-GlcNAcylation – Implications for targeting the Warburg effect in cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Shin Yee; Hagen, Thilo, E-mail: bchth@nus.edu.sg

    2015-10-02

    The high proliferation rate of cancer cells and the microenvironment in the tumor tissue require the reprogramming of tumor cell metabolism. The major mechanism of metabolic reprogramming in cancer cells is the Warburg effect, defined as the preferential utilization of glucose via glycolysis even in the presence of oxygen. Targeting the Warburg effect is considered as a promising therapeutic strategy in cancer therapy. In this regard, the glycolytic inhibitor 2-deoxyglucose (2DG) has been evaluated clinically. 2DG exerts its effect by directly inhibiting glycolysis at the level of hexokinase and phosphoglucoisomerase. In addition, 2DG is also known to induce the expression of thioredoxin interacting protein (TXNIP), a tumor suppressor protein and an important negative regulator of cellular glucose uptake. Hence, characterization of the mechanism through which 2DG regulates TXNIP expression may reveal novel approaches to target the Warburg effect in cancer cells. Therefore, in this study we sought to test various hypotheses for the mechanistic basis of the 2DG dependent TXNIP regulation. We have shown that 2DG induced TXNIP expression is independent of carbohydrate response element mediated transcription. Furthermore, the induction of TXNIP is neither dependent on the ability of 2DG to deplete cellular ATP nor to cause endoplasmic reticulum stress. We found that the 2DG induced TXNIP expression is at least in part dependent on the inhibition of the O-GlcNAcase enzyme and the accumulation of O-GlcNAc modified proteins. These results have implications for the identification of therapeutic targets to increase TXNIP expression in cancer. - Highlights: • 2DG increases TXNIP expression at the mRNA and protein level. • The effect of 2DG on TXNIP is independent of ChoRE mediated transcription. • 2DG induces TXNIP independent of ER stress induction and ATP depletion. • 2DG inhibits OGA and leads to accumulation of O-GlcNAcylated proteins. • The upregulation of

  3. Le retour de l’antique dans le cinéma italien moderne : de Warburg à Fellini et Pasolini

    Directory of Open Access Journals (Sweden)

    Anne-Violaine Houcke

    2012-08-01

    Full Text Available L’auteur se donne pour objectif de montrer en quoi il est légitime et fécond d’éclairer l’œuvre de ces deux cinéastes à la lumière des travaux d’Aby Warburg sur le Quattrocento ou sur les Hopis d’Amérique. La mise en évidence d’une identité de démarches entre l’historien de l’art et Fellini et Pasolini ouvre la perspective d’un renouvellement de la manière dont on aborde traditionnellement le rapport qu’entretiennent ces cinéastes avec le passé : le retour à l’Antiquité peut- être envisagé comme la forme d’une démarche visant à mettre au jour le retour de l’antique, entendu comme les formes symptomales d’un passé vivant dans le présent. Si Warburg ne s’est pas explicitement intéressé au cinéma, ses travaux sur l’image et les représentations ouvrent d’intéressantes perspectives sur la manière dont Fellini et Pasolini ont cherché à interroger leur propre moyen d’expression, via l’antique.I would like to show in this paper that it is legitimate and fruitful to consider Fellini’s and Pasolini’s works through Warburg’s studies of the Quattrocento or of the Hopis in America. The comparison of their methods paves the way for new perspectives on their relation to the past. Indeed, we may see the return to Antiquity in their works as a way to bring into light the return of the Antiquity, considered here as the symptomatic forms of a past still living in the present. Warburg was not particularly interested in cinema, but his work on the Image and on representations opens interesting perspectives on the way Fellini and Pasolini questioned their own means of expression, thanks to the Antiquity.

  4. New RAB3GAP1 mutations in patients with Warburg Micro Syndrome from different ethnic backgrounds and a possible founder effect in the Danish

    DEFF Research Database (Denmark)

    Morris-Rosendahl, Deborah J; Segel, Reeval; Born, A Peter

    2010-01-01

    Warburg Micro Syndrome is a rare, autosomal recessive syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. We have found...... and may aid the differential diagnosis of Micro Syndrome for patients in the future. All patients had postnatal microcephaly, micropthalmia, microcornia, bilateral congenital cataracts, short palpebral fissures, optic atrophy, severe mental retardation, and congenital hypotonia with subsequent spasticity....... Only one patient had microcephaly at birth, highlighting the fact that congenital microcephaly is not a consistent feature of Micro syndrome. Analysis of the brain magnetic resonance imagings (MRIs) revealed a consistent pattern of polymicrogyria in the frontal and parietal lobes, wide sylvian fissures...

  5. ID2 mediates the transforming growth factor-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis.

    Science.gov (United States)

    Young, Vicky J; Ahmad, Syed F; Brown, Jeremy K; Duncan, W Colin; Horne, Andrew W

    2016-09-01

    Is inhibitor of DNA-binding protein 2 (ID2) a mediator of the transforming growth factor (TGF)-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis? The TGF-β1-induced changes in the metabolic phenotype of peritoneal mesothelial cells from women with endometriosis are mediated through the ID2 pathway. TGF-β1 induces the metabolic conversion of glucose to lactate via aerobic glycolysis (the 'Warburg effect') in the peritoneum of women with endometriosis, through increased expression of the transcription factor hypoxia inducible factor α (HIF-1α). ID proteins are transcriptional targets of TGF-β1. Expression of ID2 was investigated in luteal phase peritoneal biopsies from women with regular menstrual cycles, with and without endometriosis (n = 8-10 each group) by quantitative RT-PCR (qRT-PCR) and immunohistochemistry. ID2 mRNA expression in primary human peritoneal mesothelial cells (HPMC) and immortalized mesothelial cells (MeT-5A) was assessed by qRT-PCR (n = 6). The effects of TGF-β1 and ID2 siRNA on HIF-1α mRNA expression and lactate secretion was assessed using qRT-PCR and a colorimetric lactate assay. ID2 is localized to peritoneal mesothelial and stromal cells of women with and without endometriosis. ID2 mRNA expression is lower in peritoneum adjacent to the endometriosis lesions compared to distal sites (P endometriosis. None. This work was funded by a Wellbeing of Women research grant (R42533) awarded to A.W.H., J.K.B. and W.C.D.; and an MRC Centre Grant G1002033. V.J.Y. received grant support from Federation of Women Graduates (134225) and a PhD studentship from the College of Medicine and Veterinary Medicine at the University of Edinburgh. There are no competing interests to declare. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  6. A RAB3GAP1 SINE Insertion in Alaskan Huskies with Polyneuropathy, Ocular Abnormalities, and Neuronal Vacuolation (POANV Resembling Human Warburg Micro Syndrome 1 (WARBM1

    Directory of Open Access Journals (Sweden)

    Michaela Wiedmer

    2016-02-01

    Full Text Available We observed a hereditary phenotype in Alaskan Huskies that was characterized by polyneuropathy with ocular abnormalities and neuronal vacuolation (POANV. The affected dogs developed a progressive severe ataxia, which led to euthanasia between 8 and 16 months of age. The pedigrees were consistent with a monogenic autosomal recessive inheritance. We localized the causative genetic defect to a 4 Mb interval on chromosome 19 by a combined linkage and homozygosity mapping approach. Whole genome sequencing of one affected dog, an obligate carrier, and an unrelated control revealed a 218-bp SINE insertion into exon 7 of the RAB3GAP1 gene. The SINE insertion was perfectly associated with the disease phenotype in a cohort of 43 Alaskan Huskies, and it was absent from 541 control dogs of diverse other breeds. The SINE insertion induced aberrant splicing and led to a transcript with a greatly altered exon 7. RAB3GAP1 loss-of-function variants in humans cause Warburg Micro Syndrome 1 (WARBM1, which is characterized by additional developmental defects compared to canine POANV, whereas Rab3gap1-deficient mice have a much milder phenotype than either humans or dogs. Thus, the RAB3GAP1 mutant Alaskan Huskies provide an interesting intermediate phenotype that may help to better understand the function of RAB3GAP1 in development. Furthermore, the identification of the presumed causative genetic variant will enable genetic testing to avoid the nonintentional breeding of affected dogs.

  7. Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.

    Science.gov (United States)

    Luo, Jingtao; Hong, Yun; Lu, Yang; Qiu, Songbo; Chaganty, Bharat K R; Zhang, Lun; Wang, Xudong; Li, Qiang; Fan, Zhen

    2017-01-01

    Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. AMP-activated protein kinase (AMPK) is activated after cetuximab treatment, and a sustained AMPK activity is a mechanism contributing to cetuximab resistance. Here, we investigated how acetyl-CoA carboxylase (ACC), a downstream target of AMPK, rewires cancer metabolism in response to cetuximab treatment. We found that introduction of experimental ACC mutants lacking the AMPK phosphorylation sites (ACC1_S79A and ACC2_S212A) into head and neck squamous cell carcinoma (HNSCC) cells protected HNSCC cells from cetuximab-induced growth inhibition. HNSCC cells with acquired cetuximab resistance contained not only high levels of T172-phosphorylated AMPK and S79-phosphorylated ACC1 but also an increased level of total ACC. These findings were corroborated in tumor specimens of HNSCC patients treated with cetuximab. Cetuximab plus TOFA (an allosteric inhibitor of ACC) achieved remarkable growth inhibition of cetuximab-resistant HNSCC xenografts. Our data suggest a novel paradigm in which cetuximab-mediated activation of AMPK and subsequent phosphorylation and inhibition of ACC is followed by a compensatory increase in total ACC, which rewires cancer metabolism from glycolysis-dependent to lipogenesis-dependent. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  8. A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells

    Directory of Open Access Journals (Sweden)

    Tomoaki Takai

    2017-01-01

    Full Text Available Bladder cancer is one of the most difficult malignancies to control. We explored the use of a novel RNA-interference method for a driver oncogene regulating cancer specific energy metabolism by the combination treatment with a small interfering RNA (siRNA and a microRNA. After transfection of T24 and 253JB-V cells with miR-145 and/or siR-PTBP1, we examined the effects of cell growth and gene expression by performing the trypan blue dye exclusion test, Western blot, Hoechst 33342 staining, reverse transcription polymerase chain reaction (RT-PCR, and electron microscopy. The anti-cancer effects of xenograft model mice with miR-145 and/or siR-PTBP1 were then assessed. The combination treatment induced the deeper and longer growth inhibition and reduced the levels of both mRNA and protein expression of c-Myc and polypyrimidine tract-binding protein 1 (PTBP1 more than each single treatment. Notably, the combination treatment not only impaired the cancer specific energy metabolism by inhibiting c-Myc/PTBP1/PKMs axis but also inactivated MAPK/ERK and PI3K/AKT pathways examined in vitro and in vivo. Furthermore, the combination treatment induced apoptosis or autophagy; but, in some cells, apoptotic cell death was accompanied by autophagy, because the condensation of chromatin and many autophagosomes were coexistent. This combination treatment could be a novel RNA-interference strategy through the systemic silencing of the Warburg effect-promoting driver oncogene PTBP1 in bladder cancer cells.

  9. A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton

    Directory of Open Access Journals (Sweden)

    Sarah M. Carpanini

    2014-06-01

    Full Text Available Mutations in RAB18 have been shown to cause the heterogeneous autosomal recessive disorder Warburg Micro syndrome (WARBM. Individuals with WARBM present with a range of clinical symptoms, including ocular and neurological abnormalities. However, the underlying cellular and molecular pathogenesis of the disorder remains unclear, largely owing to the lack of any robust animal models that phenocopy both the ocular and neurological features of the disease. We report here the generation and characterisation of a novel Rab18-mutant mouse model of WARBM. Rab18-mutant mice are viable and fertile. They present with congenital nuclear cataracts and atonic pupils, recapitulating the characteristic ocular features that are associated with WARBM. Additionally, Rab18-mutant cells exhibit an increase in lipid droplet size following treatment with oleic acid. Lipid droplet abnormalities are a characteristic feature of cells taken from WARBM individuals, as well as cells taken from individuals with other neurodegenerative conditions. Neurological dysfunction is also apparent in Rab18-mutant mice, including progressive weakness of the hind limbs. We show that the neurological defects are, most likely, not caused by gross perturbations in synaptic vesicle recycling in the central or peripheral nervous system. Rather, loss of Rab18 is associated with widespread disruption of the neuronal cytoskeleton, including abnormal accumulations of neurofilament and microtubule proteins in synaptic terminals, and gross disorganisation of the cytoskeleton in peripheral nerves. Global proteomic profiling of peripheral nerves in Rab18-mutant mice reveals significant alterations in several core molecular pathways that regulate cytoskeletal dynamics in neurons. The apparent similarities between the WARBM phenotype and the phenotype that we describe here indicate that the Rab18-mutant mouse provides an important platform for investigation of the disease pathogenesis and therapeutic

  10. A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton.

    Science.gov (United States)

    Carpanini, Sarah M; McKie, Lisa; Thomson, Derek; Wright, Ann K; Gordon, Sarah L; Roche, Sarah L; Handley, Mark T; Morrison, Harris; Brownstein, David; Wishart, Thomas M; Cousin, Michael A; Gillingwater, Thomas H; Aligianis, Irene A; Jackson, Ian J

    2014-06-01

    Mutations in RAB18 have been shown to cause the heterogeneous autosomal recessive disorder Warburg Micro syndrome (WARBM). Individuals with WARBM present with a range of clinical symptoms, including ocular and neurological abnormalities. However, the underlying cellular and molecular pathogenesis of the disorder remains unclear, largely owing to the lack of any robust animal models that phenocopy both the ocular and neurological features of the disease. We report here the generation and characterisation of a novel Rab18-mutant mouse model of WARBM. Rab18-mutant mice are viable and fertile. They present with congenital nuclear cataracts and atonic pupils, recapitulating the characteristic ocular features that are associated with WARBM. Additionally, Rab18-mutant cells exhibit an increase in lipid droplet size following treatment with oleic acid. Lipid droplet abnormalities are a characteristic feature of cells taken from WARBM individuals, as well as cells taken from individuals with other neurodegenerative conditions. Neurological dysfunction is also apparent in Rab18-mutant mice, including progressive weakness of the hind limbs. We show that the neurological defects are, most likely, not caused by gross perturbations in synaptic vesicle recycling in the central or peripheral nervous system. Rather, loss of Rab18 is associated with widespread disruption of the neuronal cytoskeleton, including abnormal accumulations of neurofilament and microtubule proteins in synaptic terminals, and gross disorganisation of the cytoskeleton in peripheral nerves. Global proteomic profiling of peripheral nerves in Rab18-mutant mice reveals significant alterations in several core molecular pathways that regulate cytoskeletal dynamics in neurons. The apparent similarities between the WARBM phenotype and the phenotype that we describe here indicate that the Rab18-mutant mouse provides an important platform for investigation of the disease pathogenesis and therapeutic interventions.

  11. Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect.

    Science.gov (United States)

    Unwin, Richard D; Craven, Rachel A; Harnden, Patricia; Hanrahan, Sarah; Totty, Nick; Knowles, Margaret; Eardley, Ian; Selby, Peter J; Banks, Rosamonde E

    2003-08-01

    Renal cell carcinoma (RCC) is the tenth most common cancer although the incidence is increasing. The main clinical problems stem from the relatively late presentation of many patients due to the often asymptomatic nature of the illness, and the relative insensitivity of metastatic disease to conventional chemotherapy and radiotherapy. Despite increasing knowledge of some of the genetic changes underlying sporadic renal cancer such as those involving the Von Hippel Lindau (VHL) gene, many of the underlying pathophysiological changes are ill-defined and there remains a need for the identification of disease markers for use in diagnosis and prognosis or as potential therapeutic targets. This study has used a proteomic approach, based on two-dimensional gel electrophoresis and mass spectrometry, to compare the protein profiles of conventional RCC tissue with patient-matched normal kidney cortex. Sequencing of 32 protein spots with significantly increased expression in RCC samples (>/= 4/6 patients) and 41 proteins whose levels decreased (6/6 patients) confirmed several previously known RCC-associated changes such as increases in Mn-superoxide dismutase, lactate dehydrogenase-A, aldolase A and C, pyruvate kinase M2, and thymidine phosphorylase. Additionally, several previously unknown changes were identified, including increased expression of three members of the annexin family and increased levels of the actin depolymerisation factor cofilin. The Warburg effect was also demonstrated with the identification of increases in proteins involved in the majority of steps in the glycolytic pathway and decreases in the gluconeogenic reactions, together with a parallel decrease in several mitochondrial enzymes. A number of the alterations seen were further confirmed in additional samples by immunohistochemistry, Western blotting, and laser capture microdissection.

  12. Domitian between Isis and Minerva

    DEFF Research Database (Denmark)

    Clausen, Kristine Bülow

    2013-01-01

    This paper is concerned with the sculptural decoration of the Flavian sanctuary of Isis at Beneventum. It challenges the traditional “Egyptian” appearance of the sanctuary and suggests that “Graeco-Roman” elements, too, played a role in its sculptural decoration. Based on the analysis of a small...

  13. O lugar da fotografia na construção da obra de Aby Warburg: uma perspectiva cultural para a compreensão da criação imagética

    Directory of Open Access Journals (Sweden)

    Paulo César Boni

    2015-01-01

    Full Text Available Este estudio busca discutir las relaciones planteadas entre la producción fotográfica y la construcción de la teoría warburguiana de posvida de las imá genes ( Nachleben der Antike por medio de su atlas Mnemosyne . Para tanto, utiliza la investigación bibliográca de autores que contribuirán a la elucidación de ese hecho, como Michaud (2013, Didi-Huberman (2013 y Kossoy (1989. Dado el hecho de la creación de paneles fotográcos para la aproximación de las relaciones temporales, Warburg rearma la impor- tancia de la fotografía como un objeto cultural e histórico. Para él, el atlas enfoca en la capacidad de comparación de imágenes en la historia del arte precisamente porque utiliza un panel móvil y práctico para establecer una base antropológica. Se concluye, por tanto, que Warburg usó y se ampa- ró en el potencial de la imagen fotográca para plantear una nueva mirada que rompiera con la perspectiva estática por medio de la imagen en movi- miento y del arte.

  14. Ginsenoside 20(S)-Rg3 Inhibits the Warburg Effect Via Modulating DNMT3A/ MiR-532-3p/HK2 Pathway in Ovarian Cancer Cells.

    Science.gov (United States)

    Zhou, Yuanyuan; Zheng, Xia; Lu, Jiaojiao; Chen, Wei; Li, Xu; Zhao, Le

    2018-01-01

    The Warburg effect is one of the main energy metabolism features supporting cancer cell growth. 20(S)-Rg3 exerts anti-tumor effect on ovarian cancer partly by inhibiting the Warburg effect. microRNAs are important regulators of the Warburg effect. However, the microRNA regulatory network mediating the anti-Warburg effect of 20(S)-Rg3 was largely unknown. microRNA deep sequencing was performed to identify the 20(S)-Rg3-influenced microRNAs in SKOV3 ovarian cancer cells. miR-532-3p was overexpressed by mimic532-3p transfection in SKOV3 and A2780 cells or inhibited by inhibitor532-3p transfection in 20(S)-Rg3-treated cells to examine the changes in HK2 and PKM2 expression, glucose consumption, lactate production and cell growth. Dual-luciferase reporter assay was conducted to verify the direct binding of miR-532-3p to HK2. The methylation status in the promoter region of pre-miR-532-3p gene was examined by methylation-specific PCR. Expression changes of key molecules controlling DNA methylation including DNMT1, DNMT3A, DNMT3B, and TET1-3 were examined in 20(S)-Rg3-treated cells. DNMT3A was overexpressed in 20(S)-Rg3-treated cells to examine its influence on miR-532-3p level, HK2 and PKM2 expression, glucose consumption and lactate production. Deep sequencing results showed that 11 microRNAs were increased and 9 microRNAs were decreased by 20(S)-Rg3 in SKOV3 cells, which were verified by qPCR. More than 2-fold increase of miR-532-3p was found in 20(S)-Rg3-treated SKOV3 cells. Forced expression of miR-532-3p reduced HK2 and PKM2 expression, glucose consumption and lactate production in SKOV3 and A2780 ovarian cancer cells. Inhibition of miR-532-3p antagonized the suppressive effect of 20(S)-Rg3 on HK2 and PKM2 expression, glucose consumption and lactate production in ovarian cancer cells. Dual-luciferase reporter assay showed that miR-532-3p directly suppressed HK2 rather than PKM2. miR-532-3p level was controlled by the methylation in the promoter region of its host

  15. In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous 18F-FDG-PET and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET: Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

    Directory of Open Access Journals (Sweden)

    Henrik Gutte

    2015-06-01

    Full Text Available In this communication the mismatch between simultaneous 18F-FDG-PET and a 13C-lactate imaging (hyperPET in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that 18F-FDG-PET may not always reflect the Warburg effect in all tumors.

  16. In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

    DEFF Research Database (Denmark)

    Gutte, Henrik; Hansen, Adam E; Larsen, Majbrit M E

    2015-01-01

    In this communication the mismatch between simultaneous (18)F-FDG-PET and a (13)C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that (18)F-FDG-PET may not always reflect the Warburg effect...

  17. SERRANO ESTRELLA, Felipe (coord.. Docta Minerva. Homenaje a la profesora Luz de Ulierte Vázquez. Jaén: Universidad de Jaén, 2011, 583 pp.

    Directory of Open Access Journals (Sweden)

    María del Mar Rodríguez Rodríguez

    2012-01-01

    Full Text Available Con motivo de la jubilación de la profesora Luz de Ulierte Vázquez, la Universidad de Jaén, a través de su Servicio de Publicaciones, la Facultad de Humanidades y Ciencias de la Educación, el Departamento de Patrimonio Histórico y el Grupo de Investigación “Arquitecto Vandelvira”, han promovido la realización de un libro con el que rendir homenaje a la trayectoria profesional de la doctora De Ulierte, al servicio de las universidades de Jaén y Granada. Bajo el título Docta Minerva se recogen las colaboraciones de compañeros de Historia del Arte de ambos centros, así como de Sevilla, Málaga, Córdoba, Castilla la Mancha, Castellón, Barcelona, Valencia, Veracruzana de México, etc., junto a los cuales también se encuentran investigaciones procedentes de las áreas de Historia Antigua, Filología, Psicología y Antropología.

  18. Measurement of Neutral-Current K+ Production by Neutrinos using MINERvA

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, C. M.; Aliaga, L.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Cai, T.; Carneiro, M. F.; da Motta, H.; Dytman, S. A.; Díaz, G. A.; Dunkman, M.; Eberly, B.; Endress, E.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Gallagher, H.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Hurtado, K.; Kleykamp, J.; Kordosky, M.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Caicedo, D. A. Martinez; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Mousseau, J.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman,; Paolone, V.; Patrick, C. E.; Perdue, G. N.; Ramírez, M. A.; Ransome, R. D.; Ray, H.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schmitz, D. W.; Solano Salinas, C. J.; Sultana, M.; Sánchez Falero, S.; Valencia, E.; Walton, T.; Wolcott, J.; Wospakrik, M.; Yaeggy, B.; Zhang, D.

    2017-07-01

    Neutral-current production of K+ by atmospheric neutrinos is a background in searches for the proton decay p→K+ν¯. Reactions such as νp→νK+Λ are indistinguishable from proton decays when the decay products of the Λ are below detection threshold. Events with K+ are identified in MINERvA by reconstructing the timing signature of a K+ decay at rest. A sample of 201 neutrino-induced neutral-current K+ events is used to measure differential cross sections with respect to the K+ kinetic energy, and the non-K+ hadronic visible energy. An excess of events at low hadronic visible energy is observed relative to the prediction of the neut event generator. Good agreement is observed with the cross section prediction of the genie generator. A search for photons from π0 decay, which would veto a neutral-current K+ event in a proton decay search, is performed, and a 2σ deficit of detached photons is observed relative to the genie prediction.

  19. Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice.

    Science.gov (United States)

    Jiang, Shu-Heng; Li, Jun; Dong, Fang-Yuan; Yang, Jian-Yu; Liu, De-Jun; Yang, Xiao-Mei; Wang, Ya-Hui; Yang, Min-Wei; Fu, Xue-Liang; Zhang, Xiao-Xin; Li, Qing; Pang, Xiu-Feng; Huo, Yan-Miao; Li, Jiao; Zhang, Jun-Feng; Lee, Ho-Young; Lee, Su-Jae; Qin, Wen-Xin; Gu, Jian-Ren; Sun, Yong-Wei; Zhang, Zhi-Gang

    2017-07-01

    of 5-HT to be increased in human PDAC tissues compared with non-tumor pancreatic tissues, and PDAC cell lines compared with non-transformed pancreatic cells. Incubation of PDAC cell lines with 5-HT increased proliferation and prevented apoptosis. Agonists of HTR2B, but not other 5-HT receptors, promoted proliferation and prevented apoptosis of PDAC cells. Knockdown of HTR2B in PDAC cells, or incubation of cells with HTR2B inhibitors, reduced their growth as xenograft tumors in mice. We observed a correlation between 5-HT and glycolytic flux in PDAC cells; levels of metabolic enzymes involved in glycolysis, the phosphate pentose pathway, and hexosamine biosynthesis pathway increased significantly in PDAC cells following 5-HT stimulation. 5-HT stimulation led to formation of the HTR2B-LYN-p85 complex, which increased PI3K-Akt-mTOR signaling and the Warburg effect by increasing protein levels of MYC and HIF1A. Administration of SB204741 to KPC mice slowed growth and metabolism of established pancreatic tumors and prolonged survival of the mice. Human PDACs have increased levels of 5-HT, and PDAC cells increase expression of its receptor, HTR2B. These increases allow for tumor glycolysis under metabolic stress and promote growth of pancreatic tumors and PDAC xenograft tumors in mice. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

  20. III. Cellular ultrastructures in situ as key to understanding tumor energy metabolism: biological significance of the Warburg effect [v1; ref status: indexed, http://f1000r.es/a0

    Directory of Open Access Journals (Sweden)

    Halina Witkiewicz

    2013-01-01

    Full Text Available Despite the universality of metabolic pathways, malignant cells were found to have their metabolism reprogrammed to generate energy by glycolysis even under normal oxygen concentrations (the Warburg effect. Therefore, the pathway energetically 18 times less efficient than oxidative phosphorylation was implicated to match increased energy requirements of growing tumors. The paradox was explained by an abnormally high rate of glucose uptake, assuming unlimited availability of substrates for tumor growth in vivo. However, ultrastructural analysis of tumor vasculature morphogenesis showed that the growing tissue regions did not have continuous blood supply and intermittently depended on autophagy for survival. Erythrogenic autophagy, and resulting ATP generation by glycolysis, appeared critical to initiating vasculature formation where it was missing. This study focused on ultrastructural features that reflected metabolic switch from aerobic to anaerobic. Morphological differences between and within different types of cells were evident in tissue sections. In cells undergoing nucleo-cytoplasmic conversion into erythrosomes (erythrogenesis, gradual changes led to replacing mitochondria with peroxisomes, through an intermediate form connected to endoplasmic reticulum. Those findings related to the issue of peroxisome biogenesis and to the phenomenon of hemogenic endothelium. Mitochondria were compacted also during mitosis. In vivo, cells that lost and others that retained capability to use oxygen coexisted side-by-side; both types were important for vasculature morphogenesis and tissue growth. Once passable, the new vasculature segment could deliver external oxygen and nutrients. Nutritional and redox status of microenvironment had similar effect on metabolism of malignant and non-malignant cells demonstrating the necessity to maintain structure-energy equivalence in all living cells. The role of glycolysis in initiating vasculature formation, and in

  1. Sábanas blancas en mi balcón, negra mi condición : hacia una (re)evaluación de narrativas cubanas decimonónicas sobre género, "raza" y nación en las páginas de "Minerva"

    OpenAIRE

    Colón Pichardo, Maikel

    2016-01-01

    Este artículo examina algunas de las posturas defendidas por un grupo de mujeres negras y mulatas en la revista Minerva: revista quincenal dedicada a la mujer de color, en el ocaso del siglo XIX cubano. Las líneas principales del análisis pretenden confrontar las posiciones de reivindicación racial y de género planteadas por estas autoras. A partir de ahí, se abre un debate que interacciona con las ideologías de género y «raza» interpuestas por una férrea estructura patriarcal, y que aborda s...

  2. Usage Center

    DEFF Research Database (Denmark)

    Kleinaltenkamp, Michael; Plewa, Carolin; Gudergan, Siegfried

    2017-01-01

    Purpose: The purpose of this paper is to advance extant theorizing around resourceintegration by conceptualizing and delineating the notion of a usage center. Ausage center consists of a combination of interdependent actors that draw onresources across their individual usage processes to create v...

  3. Report: After birth abortion: why should the baby live? Alcune note su un seminario di riflessione sulle questioni della procreazione a partire dall’articolo di Alberto Giubilini e Francesca Minerva. Centro Interuniversitario di Ricerca Bioetica di Napoli Università l’Orientale, Palazzo Giusso, Napoli 17 gennaio 2013

    Directory of Open Access Journals (Sweden)

    Speranza Maria Teresa

    2013-06-01

    Full Text Available After the publication of the paper by Alberto Giubilini and Francesca Minerva, two Italian researchers currently active in Australia, entitled After birth abortion: Why Should the baby live?, published in 2012, there was a great debate among scholars and journalists that induced many people to rethink the current conditions of life and death. The mass media have reported a strong controversy on this topic. Fitting into this heated exchange of views, the University Orientale of Naples, in the presence of the authors of the paper, hosted a seminar organized by CIRB (Centro Interuniversitario di Ricerca Bioetica of Naples to reflect on post‐birth abortion, which was attended by doctors, lawyers and philosophers. The meeting generated an interesting discussion on the main topics of bioethics, but left many unanswered questions.

  4. Center for Adaptive Optics | Center

    Science.gov (United States)

    Astronomy, UCSC's CfAO and ISEE, and Maui Community College, runs education and internship programs in / Jacobs Retina Center Department of Psychology University of California, San Francisco Department of University School of Optometry Maui Community College Maui Community College Space Grant Program Montana

  5. Aby Warburg's wildest dreams come true?

    NARCIS (Netherlands)

    J.P.J. Brandhorst (Hans)

    2013-01-01

    textabstractIn the midst of the "digital revolution," should we be pleased or disappointed about its effects in the field of art history? How does one answer this question, which is most likely premature and lacking in analytical acuity given what we know about art historical preferences and

  6. Genetics Home Reference: Walker-Warburg syndrome

    Science.gov (United States)

    ... cataracts ), and problems with the nerve that relays visual information from the eyes to the brain (the optic nerve ). These eye problems lead to ... some neurons migrate past the surface of the brain into the fluid-filled space that ... Less is known about the effects of the gene mutations in other parts of ...

  7. Synaptic plasticity and the warburg effect

    KAUST Repository

    Magistretti, Pierre J.

    2014-01-01

    Functional brain imaging studies show that in certain brain regions glucose utilization exceeds oxygen consumption, indicating the predominance of aerobic glycolysis. In this issue, Goyal et al. (2014) report that this metabolic profile is associated with an enrichment in the expression of genes involved in synaptic plasticity and remodeling processes. © 2014 Elsevier Inc.

  8. Synaptic plasticity and the warburg effect

    KAUST Repository

    Magistretti, Pierre J.

    2014-01-01

    Functional brain imaging studies show that in certain brain regions glucose utilization exceeds oxygen consumption, indicating the predominance of aerobic glycolysis. In this issue, Goyal et al. (2014) report that this metabolic profile

  9. Iowa Water Center | Iowa Water Center

    Science.gov (United States)

    Home Iowa State University Extension Iowa Water Center Submitted by mollyd on April 24, 2012 - 09 :42 Advancing the state of water knowledge and management The Iowa Water Center is a part of a nationwide network of university-based water centers created to encourage interdisciplinary water research

  10. Stephenson Cancer Center

    Science.gov (United States)

    Stephenson Cancer Center at the University of Oklahoma in Oklahoma City is an NCI-designated cancer center at the forefront of NCI-supported cancer research. Learn more about the Stephenson Cancer Center's mission.

  11. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Education Centers Carbon Monoxide Information Center Carbon Monoxide Information Center En Español The Invisible Killer Carbon monoxide, ... Install one and check its batteries regularly. View Information About CO Alarms Other CO Topics Safety Tips ...

  12. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Education Safety Education Centers Carbon Monoxide Information Center Carbon Monoxide Information Center En Español The Invisible Killer Carbon monoxide, also known as CO, is called the " ...

  13. Womens Business Center

    Data.gov (United States)

    Small Business Administration — Women's Business Centers (WBCs) represent a national network of nearly 100 educational centers throughout the United States and its territories, which are designed...

  14. Tornadoes: A Center Approach.

    Science.gov (United States)

    Christman-Rothlein, Liz; Meinbach, Anita M.

    1981-01-01

    Information is given on how to put together a learning center. Discusses information and activity packets for a complete learning center on tornadoes including objectives, directions, materials, photographs of physical arrangements, and posttest. (DC)

  15. Tehran Nuclear Research Center

    International Nuclear Information System (INIS)

    Taherzadeh, M.

    1977-01-01

    The Tehran Nuclear Research Center was formerly managed by the University of Tehran. This Center, after its transformation to the AEOI, has now become a focal point for basic research in the area of Nuclear Energy in Iran

  16. Day Care Centers

    Data.gov (United States)

    Department of Homeland Security — This database contains locations of day care centers for 50 states and Washington D.C. and Puerto Rico. The dataset only includes center based day care locations...

  17. Center for Functional Nanomaterials

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Functional Nanomaterials (CFN) explores the unique properties of materials and processes at the nanoscale. The CFN is a user-oriented research center...

  18. Hydrologic Engineering Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Hydrologic Engineering Center (HEC), an organization within the Institute for Water Resources, is the designated Center of Expertise for the U.S. Army Corps of...

  19. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... OnSafety Blog Safety Education Centers Neighborhood Safety Network Community Outreach Resource Center Toy Recall Statistics CO Poster ... Sitemap RSS E-mail Inside CPSC Accessibility Privacy Policy Budget, Performances & Finance Open Government Freedom of Information ( ...

  20. MARYLAND ROBOTICS CENTER

    Data.gov (United States)

    Federal Laboratory Consortium — The Maryland Robotics Center is an interdisciplinary research center housed in the Institute for Systems Research (link is external)within the A. James Clark School...

  1. Find a Health Center

    Data.gov (United States)

    U.S. Department of Health & Human Services — HRSA Health Centers care for you, even if you have no health insurance – you pay what you can afford based on your income. Health centers provide services that...

  2. NIH Clinical Centers

    Data.gov (United States)

    Federal Laboratory Consortium — The NIH Clinical Center consists of two main facilities: The Mark O. Hatfield Clinical Research Center, which opened in 2005, houses inpatient units, day hospitals,...

  3. Genetic Science Learning Center

    Science.gov (United States)

    Genetic Science Learning Center Making science and health easy for everyone to understand Home News Our Team What We Do ... Collaboration Conferences Current Projects Publications Contact The Genetic Science Learning Center at The University of Utah is a ...

  4. Poison Control Centers

    Science.gov (United States)

    ... 1222 immediately. Name State American Association of Poison Control Centers Address AAPCC Central Office NOT A POISON ... not for emergency use. Arkansas ASPCA Animal Poison Control Center Address 1717 S. Philo Road, Suite 36 Urbana, ...

  5. Data Center Tasking.

    Science.gov (United States)

    Temares, M. Lewis; Lutheran, Joseph A.

    Operations tasking for data center management is discussed. The original and revised organizational structures of the data center at the University of Miami are also described. The organizational strategy addresses the functions that should be performed by the data center, anticipates the specialized skills required, and addresses personnel…

  6. Center of buoyancy definition

    International Nuclear Information System (INIS)

    Sandberg, V.

    1988-12-01

    The center of buoyancy of an arbitrary shaped body is defined in analogy to the center of gravity. The definitions of the buoyant force and center of buoyancy in terms of integrals over the area of the body are converted to volume integrals and shown to have simple intuitive interpretations

  7. Wound care centers

    Science.gov (United States)

    Pressure ulcer - wound care center; Decubitus ulcer - wound care center; Diabetic ulcer - wound care center; Surgical wound - wound ... Common types of non-healing wounds include: Pressure sores Surgical ... flow, or swollen legs Certain wounds may not heal well due to: ...

  8. Nuclear Reaction Data Centers

    International Nuclear Information System (INIS)

    McLane, V.; Nordborg, C.; Lemmel, H.D.; Manokhin, V.N.

    1988-01-01

    The cooperating Nuclear Reaction Data Centers are involved in the compilation and exchange of nuclear reaction data for incident neutrons, charged particles and photons. Individual centers may also have services in other areas, e.g., evaluated data, nuclear structure and decay data, reactor physics, nuclear safety; some of this information may also be exchanged between interested centers. 20 refs., 1 tab

  9. Handbook on data centers

    CERN Document Server

    Khan, Samee Ullah

    2015-01-01

    This handbook offers a comprehensive review of the state-of-the-art research achievements in the field of data centers. Contributions from international, leading researchers and scholars offer topics in cloud computing, virtualization in data centers, energy efficient data centers, and next generation data center architecture.  It also comprises current research trends in emerging areas, such as data security, data protection management, and network resource management in data centers. Specific attention is devoted to industry needs associated with the challenges faced by data centers, such as various power, cooling, floor space, and associated environmental health and safety issues, while still working to support growth without disrupting quality of service. The contributions cut across various IT data technology domains as a single source to discuss the interdependencies that need to be supported to enable a virtualized, next-generation, energy efficient, economical, and environmentally friendly data cente...

  10. Call Center Capacity Planning

    DEFF Research Database (Denmark)

    Nielsen, Thomas Bang

    in order to relate the results to the service levels used in call centers. Furthermore, the generic nature of the approximation is demonstrated by applying it to a system incorporating a dynamic priority scheme. In the last paper Optimization of overflow policies in call centers, overflows between agent......The main topics of the thesis are theoretical and applied queueing theory within a call center setting. Call centers have in recent years become the main means of communication between customers and companies, and between citizens and public institutions. The extensively computerized infrastructure...... in modern call centers allows for a high level of customization, but also induces complicated operational processes. The size of the industry together with the complex and labor intensive nature of large call centers motivates the research carried out to understand the underlying processes. The customizable...

  11. The guiding center Lagrangian

    International Nuclear Information System (INIS)

    Larsson, J.

    1986-01-01

    Recursion relations determining the guiding center Langrangian Λ and the associated guiding center variables to all orders are derived. We consider some particularly simple forms of Λ obtainable by specific choices of certain arbitrary functions appearing as free parameters in the theory. It is, for example, possible to locally define the guiding center variables so that the expression for the corresponding Langrangian is unchanged by all higher order terms. (orig.)

  12. Environmental Modeling Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Environmental Modeling Center provides the computational tools to perform geostatistical analysis, to model ground water and atmospheric releases for comparison...

  13. Chemical Security Analysis Center

    Data.gov (United States)

    Federal Laboratory Consortium — In 2006, by Presidential Directive, DHS established the Chemical Security Analysis Center (CSAC) to identify and assess chemical threats and vulnerabilities in the...

  14. Center for Women Veterans

    Science.gov (United States)

    ... Business with VA Acquisition, Logistics, & Construction Small & Veteran Business Programs VetBiz.gov Financial & Asset Enterprise Management Security Investigation Center/Background Clearances Freedom of Information ...

  15. Small Business Development Center

    Data.gov (United States)

    Small Business Administration — Small Business Development Centers (SBDCs) provide assistance to small businesses and aspiring entrepreneurs throughout the United States and its territories. SBDCs...

  16. Center for Deployment Psychology

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Deployment Psychology was developed to promote the education of psychologists and other behavioral health specialists about issues pertaining to the...

  17. Advanced Simulation Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Advanced Simulation Center consists of 10 individual facilities which provide missile and submunition hardware-in-the-loop simulation capabilities. The following...

  18. Electron Microscopy Center (EMC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Electron Microscopy Center (EMC) at Argonne National Laboratory develops and maintains unique capabilities for electron beam characterization and applies those...

  19. Audio Visual Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Audiovisual Services Center provides still photographic documentation with laboratory support, video documentation, video editing, video duplication, photo/video...

  20. Test Control Center (TCC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Test Control Center (TCC) provides a consolidated facility for planning, coordinating, controlling, monitoring, and analyzing distributed test events. ,The TCC...

  1. Great Lakes Science Center

    Data.gov (United States)

    Federal Laboratory Consortium — Since 1927, Great Lakes Science Center (GLSC) research has provided critical information for the sound management of Great Lakes fish populations and other important...

  2. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... main content Languages 简体中文 English Bahasa Indonesia 한국어 Español ภาษาไทย Tiếng Việt Text Size: Decrease Font Increase ... Monoxide Information Center Carbon Monoxide Information Center En Español The Invisible Killer Carbon monoxide, also known as ...

  3. The Revitalized Tutoring Center

    Science.gov (United States)

    Koselak, Jeremy

    2017-01-01

    One high-leverage strategy rooted in a strong research base--the revitalized tutoring center--provides a wealth of opportunity to students who may be otherwise underserved. This embedded, open-all-day tutoring center supports collaborative teacher teams by using peer tutors and community volunteers. By centralizing resources and providing supports…

  4. From Periphery To Center

    DEFF Research Database (Denmark)

    Carré, David

    2014-01-01

    the notions of Center/Periphery. As Hermans (2001) proposed, center and periphery are not fixed ‘I-positions’ of the self; in this vein, these notions are explored as relevant theoretical tools for addressing the developmental trajectories involved in the construction of scientific identities. In sum...

  5. ENERGY RESOURCES CENTER

    Energy Technology Data Exchange (ETDEWEB)

    Sternberg, Virginia

    1979-11-01

    First I will give a short history of this Center which has had three names and three moves (and one more in the offing) in three years. Then I will tell you about the accomplishments made in the past year. And last, I will discuss what has been learned and what is planned for the future. The Energy and Environment Information Center (EEIC), as it was first known, was organized in August 1975 in San Francisco as a cooperative venture by the Federal Energy Administration (FEA), Energy Research and Development Administration (ERDA) and the Environmental Protection Agency (EPA). These three agencies planned this effort to assist the public in obtaining information about energy and the environmental aspects of energy. The Public Affairs Offices of FEA, ERDA and EPA initiated the idea of the Center. One member from each agency worked at the Center, with assistance from the Lawrence Berkeley Laboratory Information Research Group (LBL IRG) and with on-site help from the EPA Library. The Center was set up in a corner of the EPA Library. FEA and ERDA each contributed one staff member on a rotating basis to cover the daily operation of the Center and money for books and periodicals. EPA contributed space, staff time for ordering, processing and indexing publications, and additional money for acquisitions. The LBL Information Research Group received funds from ERDA on a 189 FY 1976 research project to assist in the development of the Center as a model for future energy centers.

  6. Accredited Birth Centers

    Science.gov (United States)

    ... Danbury, CT 06810 203-748-6000 Accredited Since March 1998 Corvallis Birth & Women's Health Center Accredited 2314 NW Kings Blvd, Suite ... Washington, DC 20002 202-398-5520 Accredited Since March 2001 Flagstaff Birth and Women's Center Accredited 401 West Aspen Avenue Flagstaff, AZ ...

  7. Technology Information Center

    International Nuclear Information System (INIS)

    Emerson, E.L.; Shepherd, E.W.; Minor, E.E.

    1980-01-01

    A Transportation Technology Center (TTC) has been established at Sandia to address the transportation of nuclear waste and spent fuel. The Technology Information Center (TIC) acts as TTC's clearing house for nuclear material transportation information. TIC's activities are divided into three activities: public information, policy information, and technical information. Some of the uses of TIC's activities are briefly outlined

  8. Funding Opportunity: Genomic Data Centers

    Science.gov (United States)

    Funding Opportunity CCG, Funding Opportunity Center for Cancer Genomics, CCG, Center for Cancer Genomics, CCG RFA, Center for cancer genomics rfa, genomic data analysis network, genomic data analysis network centers,

  9. Relative Lyapunov Center Bifurcations

    DEFF Research Database (Denmark)

    Wulff, Claudia; Schilder, Frank

    2014-01-01

    Relative equilibria (REs) and relative periodic orbits (RPOs) are ubiquitous in symmetric Hamiltonian systems and occur, for example, in celestial mechanics, molecular dynamics, and rigid body motion. REs are equilibria, and RPOs are periodic orbits of the symmetry reduced system. Relative Lyapunov...... center bifurcations are bifurcations of RPOs from REs corresponding to Lyapunov center bifurcations of the symmetry reduced dynamics. In this paper we first prove a relative Lyapunov center theorem by combining recent results on the persistence of RPOs in Hamiltonian systems with a symmetric Lyapunov...... center theorem of Montaldi, Roberts, and Stewart. We then develop numerical methods for the detection of relative Lyapunov center bifurcations along branches of RPOs and for their computation. We apply our methods to Lagrangian REs of the N-body problem....

  10. Energy efficient data centers

    Energy Technology Data Exchange (ETDEWEB)

    Tschudi, William; Xu, Tengfang; Sartor, Dale; Koomey, Jon; Nordman, Bruce; Sezgen, Osman

    2004-03-30

    Data Center facilities, prevalent in many industries and institutions are essential to California's economy. Energy intensive data centers are crucial to California's industries, and many other institutions (such as universities) in the state, and they play an important role in the constantly evolving communications industry. To better understand the impact of the energy requirements and energy efficiency improvement potential in these facilities, the California Energy Commission's PIER Industrial Program initiated this project with two primary focus areas: First, to characterize current data center electricity use; and secondly, to develop a research ''roadmap'' defining and prioritizing possible future public interest research and deployment efforts that would improve energy efficiency. Although there are many opinions concerning the energy intensity of data centers and the aggregate effect on California's electrical power systems, there is very little publicly available information. Through this project, actual energy consumption at its end use was measured in a number of data centers. This benchmark data was documented in case study reports, along with site-specific energy efficiency recommendations. Additionally, other data center energy benchmarks were obtained through synergistic projects, prior PG&E studies, and industry contacts. In total, energy benchmarks for sixteen data centers were obtained. For this project, a broad definition of ''data center'' was adopted which included internet hosting, corporate, institutional, governmental, educational and other miscellaneous data centers. Typically these facilities require specialized infrastructure to provide high quality power and cooling for IT equipment. All of these data center types were considered in the development of an estimate of the total power consumption in California. Finally, a research ''roadmap'' was developed

  11. Information sharing guidebook for transportation management centers, emergency operations centers, and fusion centers

    Science.gov (United States)

    2010-06-01

    This guidebook provides an overview of the mission and functions of transportation management centers, emergency operations centers, and fusion centers. The guidebook focuses on the types of information these centers produce and manage and how the sh...

  12. Information sharing guidebook for transportation management centers, emergency operations centers, and fusion centers.

    Science.gov (United States)

    2010-06-01

    This guidebook provides an overview of the mission and functions of transportation management centers, emergency operations centers, and fusion centers. The guidebook focuses on the types of information these centers produce and manage and how the sh...

  13. User-centered design

    International Nuclear Information System (INIS)

    Baik, Joo Hyun; Kim, Hyeong Heon

    2008-01-01

    The simplification philosophy, as an example, that both of EPRI-URD and EUR emphasize is treated mostly for the cost reduction of the nuclear power plants, but not for the simplification of the structure of user's tasks, which is one of the principles of user-centered design. A user-centered design is a philosophy based on the needs and interests of the user, with an emphasis on making products usable and understandable. However, the nuclear power plants offered these days by which the predominant reactor vendors are hardly user-centered but still designer-centered or technology-centered in viewpoint of fulfilling user requirements. The main goal of user-centered design is that user requirements are elicited correctly, reflected properly into the system requirements, and verified thoroughly by the tests. Starting from the user requirements throughout to the final test, each requirement should be traceable. That's why requirement traceability is a key to the user-centered design, and main theme of a requirement management program, which is suggested to be added into EPRI-URD and EUR in the section of Design Process. (author)

  14. Advanced Cancer Detection Center

    National Research Council Canada - National Science Library

    Ruckdeschel, John

    1999-01-01

    ... through screening, and the testing of methods to prevent cancer. In addition, the Center created and supports education programs to provide increased cancer awareness and established working collaborations with the James...

  15. Advanced Missile Signature Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Advanced Missile Signature Center (AMSC) is a national facility supporting the Missile Defense Agency (MDA) and other DoD programs and customers with analysis,...

  16. FEMA Disaster Recovery Centers

    Data.gov (United States)

    Department of Homeland Security — This is a search site for FEMA's Disaster Recovery Centers (DRC). A DRC is a readily accessible facility or mobile office set up by FEMA where applicants may go for...

  17. World Trade Center

    Index Scriptorium Estoniae

    2006-01-01

    Esilinastus katastroofifilm "World Trade Center" : stsenarist Andrea Berloff : režissöör Oliver Stone : kunstnik Jan Roelfs : osades Nicholas Cage, Michael Pena, Stephen Dorff jpt : Ameerika Ühendriigid 2006. Ka filmi prototüüpidest

  18. USU Patient Simulation Center

    Data.gov (United States)

    Federal Laboratory Consortium — he National Capital Area (NCA) Medical Simulation Center is a state-of-the-art training facility located near the main USU campus. It uses simulated patients (i.e.,...

  19. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Community Outreach Resource Center Toy Recall Statistics CO Poster Contest Pool Safely Business & Manufacturing Business & Manufacturing Business ... Featured Resources CPSC announces winners of carbon monoxide poster contest Video View the blog Clues You Can ...

  20. Center for Contaminated Sediments

    Data.gov (United States)

    Federal Laboratory Consortium — The U.S. Army Corps of Engineers Center for Contaminated Sediments serves as a clearinghouse for technology and expertise concerned with contaminated sediments. The...

  1. Reliability Centered Maintenance - Methodologies

    Science.gov (United States)

    Kammerer, Catherine C.

    2009-01-01

    Journal article about Reliability Centered Maintenance (RCM) methodologies used by United Space Alliance, LLC (USA) in support of the Space Shuttle Program at Kennedy Space Center. The USA Reliability Centered Maintenance program differs from traditional RCM programs because various methodologies are utilized to take advantage of their respective strengths for each application. Based on operational experience, USA has customized the traditional RCM methodology into a streamlined lean logic path and has implemented the use of statistical tools to drive the process. USA RCM has integrated many of the L6S tools into both RCM methodologies. The tools utilized in the Measure, Analyze, and Improve phases of a Lean Six Sigma project lend themselves to application in the RCM process. All USA RCM methodologies meet the requirements defined in SAE JA 1011, Evaluation Criteria for Reliability-Centered Maintenance (RCM) Processes. The proposed article explores these methodologies.

  2. Mental Health Screening Center

    Science.gov (United States)

    ... Releases & Announcements Public Service Announcements Partnering with DBSA Mental Health Screening Center These online screening tools are not ... you have any concerns, see your doctor or mental health professional. Depression Screening for Adult Depression Screening for ...

  3. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Reports Injury Statistics NEISS Injury Data Consumer Opinion Surveys About CPSC About CPSC Chairman Commissioners Contact / FAQ ... Guide View All CO Safety Guides ")); jQuery(".node-type-safety-education-center .region-sidebar-second").css('display', " ...

  4. Climate Prediction Center - Outlooks

    Science.gov (United States)

    Weather Service NWS logo - Click to go to the NWS home page Climate Prediction Center Home Site Map News Web resources and services. HOME > Outreach > Publications > Climate Diagnostics Bulletin Climate Diagnostics Bulletin - Tropics Climate Diagnostics Bulletin - Forecast Climate Diagnostics

  5. Heart Information Center

    Science.gov (United States)

    ... Rounds Seminar Series & Daily Conferences Fellowships and Residencies School of Perfusion Technology Education Resources Library & Learning Resource Center CME Resources THI Journal THI Cardiac Society Register for the Cardiac Society ...

  6. Cooperative Tagging Center (CTC)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Cooperative Tagging Center (CTC) began as the Cooperative Game Fish Tagging Program (GTP) at Woods Hole Oceanographic Institute (WHOI) in 1954. The GTP was...

  7. National Automotive Center - NAC

    Data.gov (United States)

    Federal Laboratory Consortium — Encouraged by the advantages of collaboration, the U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) worked with the Secretary of the...

  8. Center for Hydrogen Storage.

    Science.gov (United States)

    2013-06-01

    The main goals of this project were to (1) Establish a Center for Hydrogen Storage Research at Delaware State University for the preparation and characterization of selected complex metal hydrides and the determination their suitability for hydrogen ...

  9. Mobility Data Analytics Center.

    Science.gov (United States)

    2016-01-01

    Mobility Data Analytics Center aims at building a centralized data engine to efficiently manipulate : large-scale data for smart decision making. Integrating and learning the massive data are the key to : the data engine. The ultimate goal of underst...

  10. HUD Homeownership Centers

    Data.gov (United States)

    Department of Housing and Urban Development — HUD Homeownership Centers (HOCs) insure single family Federal Housing Administration (FHA) mortgages and oversee the selling of HUD homes. FHA has four Homeownership...

  11. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... CONSUMER PRODUCT SAFETY COMMISSION Search CPSC Search Menu Home Recalls Recall List CPSC Recall API Recall Lawsuits ... and Bans Report an Unsafe Product Consumers Businesses Home Safety Education Safety Education Centers Carbon Monoxide Information ...

  12. - Oklahoma Water Resources Center

    Science.gov (United States)

    Development Ag Business Community & Rural Development Crops Family & Consumer Sciences Gardening Family & Consumer Sciences Food & Ag Products Center Horticulture & Landscape Architecture & Landscape Architecture Natural Resource Ecology & Management Plant & Soil Sciences

  13. World data centers

    Science.gov (United States)

    Shapley, Alan H.; Hart, Pembroke J.

    One of the lasting heritages of the International Geophysical Year (1957-58) is the system of world data centers (WDC) through which there has been international exchange of a wide variety of geophysical data on a continuing basis. This voluntary exchange mechanism has been remarkably successful. The basic operating costs of the centers are provided by the host country. The international exchanges are mainly by barter. The data providers number in the thousands and the users in the tens of thousands.

  14. PACS for imaging centers.

    Science.gov (United States)

    Farnsworth, T J

    2003-01-01

    PACS can be a difficult and confusing decision for any radiology provider, but it can be an even more dynamic question for an outpatient imaging center. Every center represents a unique situation and requires a specialized solution. Typically, most of what is said and discussed about PACS concentrates on solutions and requirements for hospital radiology facilities. Administrators of imaging centers have different problems from hospital administrators, and they need different answers. For imaging centers, the financial justification for PACS may be less immediate than for hospitals. The first thing that must be understood is that no PAC system can make a typical imaging center completely filmless, at least not for quite a while. A hospital has the ability to dictate to its internal referring physicians how a radiological study is delivered, whereas in an imaging center environment, the roles are very much reversed. Once the justification are made for the financial viability of PACS in an imaging center, the next question is how to finance the acquisition of PACS. The decision will depend on how you cost justify your PACS, as well as the shape of your business model, and it will come to a decision between capital purchase or contracting with an application service provider, or ASP. Historically, in the hospital-dominated marketplace, PAC systems have been treated as capital acquisitions. However, for most imaging center, owning the system is more of a problem than a benefit. ASPs increasingly represent a successful alternative for imaging centers. One of the biggest things to consider with PACS is how to store all of those images. There are typically two options, on-site and off-site, with a new "hybrid" option surfacing more recently. Each option has benefits for the user, but the benefits of off-site storage are increasing as the technology advances. Some of the benefits are data security and access. Other issues to address are HIPAA compliance, standardized

  15. "Infotonics Technology Center"

    Energy Technology Data Exchange (ETDEWEB)

    Fritzemeier, L. [Infotonics Technology Center Inc., Canandaigua, NY (United States); Boysel, M. B. [Infotonics Technology Center Inc., Canandaigua, NY (United States); Smith, D. R. [Infotonics Technology Center Inc., Canandaigua, NY (United States)

    2004-09-30

    During this grant period July 15, 2002 thru September 30, 2004, the Infotonics Technology Center developed the critical infrastructure and technical expertise necessary to accelerate the development of sensors, alternative lighting and power sources, and other specific subtopics of interest to Department of Energy. Infotonics fosters collaboration among industry, universities and government and operates as a national center of excellence to drive photonics and microsystems development and commercialization. A main goal of the Center is to establish a unique, world-class research and development facility. A state-of-the-art microsystems prototype and pilot fabrication facility was established to enable rapid commercialization of new products of particular interest to DOE. The Center has three primary areas of photonics and microsystems competency: device research and engineering, packaging and assembly, and prototype and pilot-scale fabrication. Center activities focused on next generation optical communication networks, advanced imaging and information sensors and systems, micro-fluidic systems, assembly and packaging technologies, and biochemical sensors. With targeted research programs guided by the wealth of expertise of Infotonics business and scientific staff, the fabrication and packaging facility supports and accelerates innovative technology development of special interest to DOE in support of its mission and strategic defense, energy, and science goals.

  16. Engineer Research and Development Center's Materials Testing Center (MTC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Engineer Research and Development Center's Materials Testing Center (MTC) is committed to quality testing and inspection services that are delivered on time and...

  17. The USC Epigenome Center.

    Science.gov (United States)

    Laird, Peter W

    2009-10-01

    The University of Southern California (USC, CA, USA) has a long tradition of excellence in epigenetics. With the recent explosive growth and technological maturation of the field of epigenetics, it became clear that a dedicated high-throughput epigenomic data production facility would be needed to remain at the forefront of epigenetic research. To address this need, USC launched the USC Epigenome Center as the first large-scale center in academics dedicated to epigenomic research. The Center is providing high-throughput data production for large-scale genomic and epigenomic studies, and developing novel analysis tools for epigenomic research. This unique facility promises to be a valuable resource for multidisciplinary research, education and training in genomics, epigenomics, bioinformatics, and translational medicine.

  18. International Water Center

    Science.gov (United States)

    The urban district of Nancy and the Town of Nancy, France, have taken the initiative of creating an International Center of Water (Centre International de l'Eau à Nancy—NAN.C.I.E.) in association with two universities, six engineering colleges, the Research Centers of Nancy, the Rhine-Meuse Basin Agency, and the Chamber of Commerce and Industry. The aim of this center is to promote research and technology transfer in the areas of water and sanitation. In 1985 it will initiate a research program drawing on the experience of 350 researchers and engineers of various disciplines who have already been assigned to research in these fields. The research themes, the majority of which will be multidisciplinary, concern aspects of hygiene and health, the engineering of industrial processes, water resources, and the environment and agriculture. A specialist training program offering five types of training aimed at university graduates, graduates of engineering colleges, or experts, will start in October 1984.

  19. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Centers Regional Benefits Offices Regional Loan Centers Cemetery Locations Get help from Veterans Crisis Line Search Enter ... Experience (TEE) Tournament Wheelchair Games Winter Sports Clinic Locations Hospitals & Clinics Vet Centers Regional Benefits Offices Regional ...

  20. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business ... Community Providers and Clergy Co-Occurring Conditions Continuing Education Publications List of Center Publications Articles by Center ...

  1. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... TEE) Tournament Wheelchair Games Winter Sports Clinic Locations Hospitals & Clinics Vet Centers Regional Benefits Offices Regional Loan Centers ... Prevention / Wellness Public Health Weight Management (MOVE!) Locations Hospitals & Clinics Vet Centers Veterans Canteen Service (VCS) Research Research ...

  2. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Performance VA Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery ... Community Providers and Clergy Co-Occurring Conditions Continuing Education Publications List of Center Publications Articles by Center ...

  3. QUAD FAMILY CENTERING

    International Nuclear Information System (INIS)

    PINAYEV, I.

    2005-01-01

    It is well known that beam position monitors (BPM) utilizing signals from pickup electrodes (PUE) provide good resolution and relative accuracy. The absolute accuracy (i.e. position of the orbit in the vacuum chamber) is not very good due to the various reasons. To overcome the limitation it was suggested to use magnetic centers of quadrupoles for the calibration of the BPM [1]. The proposed method provides accuracy better then 200 microns for centering of the beam position monitors using modulation of the whole quadrupole family

  4. Lied Transplant Center

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    The Department of Energy has prepared an Environmental Assessment (DOE/EA-1143) evaluating the construction, equipping and operation of the proposed Lied Transplant Center at the University of Nebraska Medical Center in Omaha, Nebraska. Based on the analysis in the EA, the DOE has determined that the proposed action does not constitute a major federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an Environmental Statement in not required.

  5. Starting an aphasia center?

    Science.gov (United States)

    Elman, Roberta J

    2011-08-01

    Starting an aphasia center can be an enormous challenge. This article provides initial issues to review and consider when deciding whether starting a new organization is right for you. Determining the need for the program in your community, the best size and possible affiliation for the organization, and available resources, as well as developing a business plan, marketing the program, and building awareness in the community, are some of the factors that are discussed. Specific examples related to starting the Aphasia Center of California are provided. © Thieme Medical Publishers.

  6. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Topics For Veterans For Researchers Research Oversight Special Groups Caregivers Combat Veterans & their Families Readjustment Counseling (Vet Centers) War Related Illness & Injury Study Center ...

  7. Crib Information Center

    Science.gov (United States)

    ... 한국어 Español ภาษาไทย Tiếng Việt Text Size: Decrease Font Increase Font Contact CPSC Consumers: Businesses: Report an Unsafe Product ... Department of Health (HRSA) NICHD text4baby ")); jQuery(".node-type-safety-education-center .region-sidebar-second").css('display', " ...

  8. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... 한국어 Español ภาษาไทย Tiếng Việt Text Size: Decrease Font Increase Font Contact CPSC Consumers: Businesses: Report an Unsafe Product ... Guide View All CO Safety Guides ")); jQuery(".node-type-safety-education-center .region-sidebar-second").css('display', " ...

  9. Carbon Monoxide Information Center

    Science.gov (United States)

    ... 한국어 Español ภาษาไทย Tiếng Việt Text Size: Decrease Font Increase Font Contact CPSC Consumers: Businesses: Report an Unsafe Product ... Guide View All CO Safety Guides ")); jQuery(".node-type-safety-education-center .region-sidebar-second").css('display', " ...

  10. Distribution center consolidation games

    NARCIS (Netherlands)

    Klijn, F.; Slikker, M.

    2005-01-01

    We study a location-inventory model to analyze the impact of consolidation of distribution centers on facility and inventory costs. We introduce a cooperative game and show that when demand processes are i.i.d. the core is non-empty, i.e., consolidation allows for a stable division of the minimal

  11. Carolinas Energy Career Center

    Energy Technology Data Exchange (ETDEWEB)

    Classens, Anver; Hooper, Dick; Johnson, Bruce

    2013-03-31

    Central Piedmont Community College (CPCC), located in Charlotte, North Carolina, established the Carolinas Energy Career Center (Center) - a comprehensive training entity to meet the dynamic needs of the Charlotte region's energy workforce. The Center provides training for high-demand careers in both conventional energy (fossil) and renewable energy (nuclear and solar technologies/energy efficiency). CPCC completed four tasks that will position the Center as a leading resource for energy career training in the Southeast: • Development and Pilot of a New Advanced Welding Curriculum, • Program Enhancement of Non-Destructive Examination (NDE) Technology, • Student Support through implementation of a model targeted toward Energy and STEM Careers to support student learning, • Project Management and Reporting. As a result of DOE funding support, CPCC achieved the following outcomes: • Increased capacity to serve and train students in emerging energy industry careers; • Developed new courses and curricula to support emerging energy industry careers; • Established new training/laboratory resources; • Generated a pool of highly qualified, technically skilled workers to support the growing energy industry sector.

  12. School Based Health Centers

    Science.gov (United States)

    Children's Aid Society, 2012

    2012-01-01

    School Based Health Centers (SBHC) are considered by experts as one of the most effective and efficient ways to provide preventive health care to children. Few programs are as successful in delivering health care to children at no cost to the patient, and where they are: in school. For many underserved children, The Children's Aid Society's…

  13. The Women's Center.

    Science.gov (United States)

    Stimpson, Catharine R.; And Others

    Barnard College has created a Women's Center that devotes itself to the task of reaffirming the dignity, autonomy, and equality of women. For too long society has held that women are less rational than men, less capable than men, and thus that educating women is less useful than educating men. Replacing myth with fact is the responsibility of…

  14. Climate Prediction Center

    Science.gov (United States)

    Weather Service NWS logo - Click to go to the NWS home page Climate Prediction Center Home Site Map News Organization Enter Search Term(s): Search Search the CPC Go NCEP Quarterly Newsletter Climate Highlights U.S Climate-Weather El Niño/La Niña MJO Blocking AAO, AO, NAO, PNA Climatology Global Monsoons Expert

  15. Ocean Prediction Center

    Science.gov (United States)

    Social Media Facebook Twitter YouTube Search Search For Go NWS All NOAA Weather Analysis & Forecasts of Commerce Ocean Prediction Center National Oceanic and Atmospheric Administration Analysis & Unified Surface Analysis Ocean Ocean Products Ice & Icebergs NIC Ice Products NAIS Iceberg Analysis

  16. National Pesticide Information Center

    Science.gov (United States)

    ... How can I protect my pets when using pesticides around them? More FAQs FAQ Comics Video FAQs From NPIC: Fact Sheets Videos Web Apps Podcasts Outreach Materials NPIC Professional Resources Social Media: National Pesticide Information Center Tweets by NPICatOSU Please read our ...

  17. Queering the Writing Center

    Science.gov (United States)

    Denny, Harry

    2010-01-01

    Composition classrooms and writing centers are spaces where negotiation of academic, social, cultural, and political identities are ubiquitous, yet research has not produced adequate theory and practice to help tutors and writers navigate identity production and its politics. This article seeks to begin conversations that might lead to better…

  18. Precision Joining Center

    Science.gov (United States)

    Powell, J. W.; Westphal, D. A.

    1991-08-01

    A workshop to obtain input from industry on the establishment of the Precision Joining Center (PJC) was held on July 10-12, 1991. The PJC is a center for training Joining Technologists in advanced joining techniques and concepts in order to promote the competitiveness of U.S. industry. The center will be established as part of the DOE Defense Programs Technology Commercialization Initiative, and operated by EG&G Rocky Flats in cooperation with the American Welding Society and the Colorado School of Mines Center for Welding and Joining Research. The overall objectives of the workshop were to validate the need for a Joining Technologists to fill the gap between the welding operator and the welding engineer, and to assure that the PJC will train individuals to satisfy that need. The consensus of the workshop participants was that the Joining Technologist is a necessary position in industry, and is currently used, with some variation, by many companies. It was agreed that the PJC core curriculum, as presented, would produce a Joining Technologist of value to industries that use precision joining techniques. The advantage of the PJC would be to train the Joining Technologist much more quickly and more completely. The proposed emphasis of the PJC curriculum on equipment intensive and hands-on training was judged to be essential.

  19. Centering of quadrupole family

    International Nuclear Information System (INIS)

    Pinayev, Igor

    2007-01-01

    A procedure for finding the individual centers for a family of quadrupoles fed with a single power supply is described. The method is generalized for using the correctors adjacent to the quadrupoles. Theoretical background is presented as well as experimental data for the NSLS rings. The method accuracy is also discussed

  20. Guiding center drift equations

    International Nuclear Information System (INIS)

    Boozer, A.H.

    1979-03-01

    The quations for particle guiding center drift orbits are given in a new magnetic coordinate system. This form of the equations not only separates the fast motion along the lines from the slow motion across, but also requires less information about the magnetic field than many other formulations of the problem

  1. vCenter troubleshooting

    CERN Document Server

    Mills, Chuck

    2015-01-01

    The book is designed for the competent vCenter administrator or anyone who is responsible for the vSphere environment. It can be used as a guide by vSphere architects and VMware consultants for a successful vSphere solution. You should have good knowledge and an understanding of core elements and applications of the vSphere environment.

  2. Water Resources Research Center

    Science.gov (United States)

    Untitled Document  Search Welcome to the University of Hawai'i at Manoa Water Resources Research Center At WRRC we concentrate on addressing the unique water and wastewater management problems and issues elsewhere by researching water-related issues distinctive to these areas. We are Hawaii's link in a network

  3. Starting a sleep center.

    Science.gov (United States)

    Epstein, Lawrence J; Valentine, Paul S

    2010-05-01

    The demand for sleep medicine services has grown tremendously during the last decade and will likely continue. To date, growth in demand has been met by growth in the number of new sleep centers. The need for more new centers will be dependent on market drivers that include increasing regulatory requirements, personnel shortages, integration of home sleep testing, changes in reimbursement, a shift in emphasis from diagnostics to treatment, and an increased consumer focus on sleep. The decision to open a new center should be based on understanding the market dynamics, completing a market analysis, and developing a business plan. The business plan should include an overview of the facility, a personnel and organizational structure, an evaluation of the business environment, a financial plan, a description of services provided, and a strategy for obtaining, managing, and extending a referral base. Implementation of the business plan and successful operation require ongoing planning and monitoring of operational parameters. The need for new sleep centers will likely continue, but the shifting market dynamics indicate a greater need for understanding the marketplace and careful planning.

  4. The Precarious Question of Black Cultural Centers Versus Multicultural Centers.

    Science.gov (United States)

    Princes, Carolyn D. W.

    This paper discusses the role of black cultural centers on university campuses, focusing on whether black cultural centers or multicultural centers best meet the needs of an increasingly diverse student body and society. It examines the historical role of black cultural centers as vehicles to promote educational opportunity, student retention, and…

  5. User-Centered Design through Learner-Centered Instruction

    Science.gov (United States)

    Altay, Burçak

    2014-01-01

    This article initially demonstrates the parallels between the learner-centered approach in education and the user-centered approach in design disciplines. Afterward, a course on human factors that applies learner-centered methods to teach user-centered design is introduced. The focus is on three tasks to identify the application of theoretical and…

  6. Stern-Center Potsdam; Stern-Center Potsdam

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1999-07-01

    The ''Stern-Center Potsdam'' is a star-shaped shopping mall in the city center. [German] Das Stern-Center in Potsdam bietet als Einkaufszentrum vor den Toren Berlins Platz fuer eine Vielzahl von Geschaeften. Die sternfoermige Gebaeudestruktur des Centers bildet den Mittelpunkt des Stadtviertels 'Am Stern'. (orig.)

  7. NREL's Education Center Programs | NREL

    Science.gov (United States)

    NREL's Education Center Programs NREL's Education Center Programs There are a variety of educational programs offered through NREL's education center to inspire our community to explore the science neighbors, campus and trail maps, and more. A photo of the NREL Education Center exterior. Programs for

  8. Alternative Fuels Data Center: Biodiesel

    Science.gov (United States)

    Biodiesel Printable Version Share this resource Send a link to Alternative Fuels Data Center : Biodiesel to someone by E-mail Share Alternative Fuels Data Center: Biodiesel on Facebook Tweet about Alternative Fuels Data Center: Biodiesel on Twitter Bookmark Alternative Fuels Data Center: Biodiesel on

  9. Revisiting the student centered

    DEFF Research Database (Denmark)

    Sarauw, Laura Louise

    2018-01-01

    Has the orthodoxy of progressive pedagogy, or what praise as the student centered, become means of an overall managerial turn that erodes students’ freedom do learn? This is the main question in Bruce Macfarlane’s book Freedom to learn - The Threat to Student Academic Freedom and Why it Needs...... to be Reclaimed (2017). In eighth well-written chapters, Macfarlane explores an often-overlooked paradox in higher education teaching and learning: The idea of the student centered learning, deriving from humanist psychology and progressive pedagogy, has been hijacked by increased and continuous demands of bodily......, cognitive and emotional performance that restricts students’ freedom to develop as autonomous adults. Macfarlane’s catch 22 is, however, that his heritage from humanist psychology, i.e. the idea that we as humans are born with an inner potential that we should be free to realise though education...

  10. COMPUTATIONAL SCIENCE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    DAVENPORT,J.

    2004-11-01

    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security.

  11. The Center is Everywhere

    OpenAIRE

    Weinberg, David H.

    2012-01-01

    "The Center is Everywhere" is a sculpture by Josiah McElheny, currently (through October 14, 2012) on exhibit at the Institute of Contemporary Art, Boston. The sculpture is based on data from the Sloan Digital Sky Survey (SDSS), using hundreds of glass crystals and lamps suspended from brass rods to represent the three-dimensional structure mapped by the SDSS through one of its 2000+ spectroscopic plugplates. This article describes the scientific ideas behind this sculpture, emphasizing the p...

  12. Evaluate Data Center Network Performance

    DEFF Research Database (Denmark)

    Pilimon, Artur

    through a data center network, which is usually built with layer 2 switches and layer 3 routers. The topology of the data center network is crucial for latency in the data communication to and from the data center and between servers in the data center. Tests can be conducted to measure latency and other...... Engineering, scientists evaluate data center network topologies with an SDN-based (Software-Defined Networking) control framework measuring network performance – primarily latency. This can be used to plan data center scaling by testing how a new topology will function before changes are made. Data center...... performance parameters for different data center network topologies. It is however important that tests can be repeated and reproduced to have comparable information from the tests. There are, of course, many topologies that can be used for data center networks. At DTU Fotonik, Department of Photonics...

  13. Solar Technology Center

    Energy Technology Data Exchange (ETDEWEB)

    Boehm, Bob

    2011-04-27

    The Department of Energy, Golden Field Office, awarded a grant to the UNLV Research Foundation (UNLVRF) on August 1, 2005 to develop a solar and renewable energy information center. The Solar Technology Center (STC) is to be developed in two phases, with Phase I consisting of all activities necessary to determine feasibility of the project, including design and engineering, identification of land access issues and permitting necessary to determine project viability without permanently disturbing the project site, and completion of a National Environmental Policy Act (NEPA) Environmental Assessment. Phase II is the installation of infrastructure and related structures, which leads to commencement of operations of the STC. The STC is located in the Boulder City designated 3,000-acre Eldorado Valley Energy Zone, approximately 15 miles southwest of downtown Boulder City and fronting on Eldorado Valley Drive. The 33-acre vacant parcel has been leased to the Nevada Test Site Development Corporation (NTSDC) by Boulder City to accommodate a planned facility that will be synergistic with present and planned energy projects in the Zone. The parcel will be developed by the UNLVRF. The NTSDC is the economic development arm of the UNLVRF. UNLVRF will be the entity responsible for overseeing the lease and the development project to assure compliance with the lease stipulations established by Boulder City. The STC will be operated and maintained by University of Nevada, Las Vegas (UNLV) and its Center for Energy Research (UNLV-CER). Land parcels in the Eldorado Valley Energy Zone near the 33-acre lease are committed to the construction and operation of an electrical grid connected solar energy production facility. Other projects supporting renewable and solar technologies have been developed within the energy zone, with several more developments in the horizon.

  14. [Client centered psychotherapy].

    Science.gov (United States)

    Werthmann, H V

    1979-01-01

    In the discussion concerning which psychotherapeutic methods should come under the auspices of the medical health system in West Germany, the question is raised regarding the client-centered therapy of Carl Rogers. Can it be considered a distinct psychotherapeutic method? A review of the scientific literature dealing with this method shows that it provides neither a theory of mental illness nor a theory of clinical application based on individual cases or specific neurotic disturbances, Therefore it should be categorized as a useful method of communication in the field of psychology and not as a therapeutic method for treating mental illness.

  15. FFTF Work Control Center

    International Nuclear Information System (INIS)

    Talbot, M.D.

    1986-01-01

    A centralized Work Control Center (WCC) is responsible for assuring that maintenance and modification of the Fast Flux Test Facility (FFTF) is performed in accordance with written procedures that ensure design integrity, personnel and public safety, and equipment and system availability for the computerized Master Information Data Acquisition System (MIDAS). Each maintenance task is logged into MIDAS from a Work Request from that has been reviewed and prioritized by the WCC. Thereafter, MIDAS is used to track schedule, manpower and material requirements; authorize field work; and close out the maintenance activity

  16. COMPUTATIONAL SCIENCE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    DAVENPORT, J.

    2005-11-01

    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include, for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security. To achieve our goals we have established a close alliance with applied mathematicians and computer scientists at Stony Brook and Columbia Universities.

  17. Illinois Accelerator Research Center

    Science.gov (United States)

    Kroc, Thomas K.; Cooper, Charlie A.

    The Illinois Accelerator Research Center (IARC) hosts a new accelerator development program at Fermi National Accelerator Laboratory. IARC provides access to Fermi's state-of-the-art facilities and technologies for research, development and industrialization of particle accelerator technology. In addition to facilitating access to available existing Fermi infrastructure, the IARC Campus has a dedicated 36,000 ft2 Heavy Assembly Building (HAB) with all the infrastructure needed to develop, commission and operate new accelerators. Connected to the HAB is a 47,000 ft2 Office, Technology and Engineering (OTE) building, paid for by the state, that has office, meeting, and light technical space. The OTE building, which contains the Accelerator Physics Center, and nearby Accelerator and Technical divisions provide IARC collaborators with unique access to world class expertise in a wide array of accelerator technologies. At IARC scientists and engineers from Fermilab and academia work side by side with industrial partners to develop breakthroughs in accelerator science and translate them into applications for the nation's health, wealth and security.

  18. Phenomenological three center model

    CERN Document Server

    Poenaru, D N; Gherghescu, R A; Nagame, Y; Hamilton, J H; Ramayya, A V

    2001-01-01

    Experimental results on ternary fission of sup 2 sup 5 sup 2 Cf suggest the existence of a short-lived quasi-molecular state. We present a three-center phenomenological model able to explain such a state by producing a new minimum in the deformation energy at a separation distance very close to the touching point. The shape parametrization chosen by us allows to describe the essential geometry of the systems in terms of one independent coordinate, namely, the distance between the heavy fragment centers. The shell correction (also treated phenomenologically) only produces quantitative effects; qualitatively it is not essential for the new minimum. Half-lives of some quasi-molecular states which could be formed in sup 1 sup 0 B accompanied fission of sup 2 sup 3 sup 6 U, sup 2 sup 3 sup 6 Pu, sup 2 sup 4 sup 6 Cm, sup 2 sup 5 sup 2 Cf, sup 2 sup 5 sup 2 sup , sup 2 sup 5 sup 6 Fm, sup 2 sup 5 sup 6 sup , sup 2 sup 6 sup 0 No, and sup 2 sup 6 sup 2 Rf are roughly estimated. (authors)

  19. Sustainable Biofuels Development Center

    Energy Technology Data Exchange (ETDEWEB)

    Reardon, Kenneth F. [Colorado State Univ., Fort Collins, CO (United States)

    2015-03-01

    The mission of the Sustainable Bioenergy Development Center (SBDC) is to enhance the capability of America’s bioenergy industry to produce transportation fuels and chemical feedstocks on a large scale, with significant energy yields, at competitive cost, through sustainable production techniques. Research within the SBDC is organized in five areas: (1) Development of Sustainable Crops and Agricultural Strategies, (2) Improvement of Biomass Processing Technologies, (3) Biofuel Characterization and Engine Adaptation, (4) Production of Byproducts for Sustainable Biorefining, and (5) Sustainability Assessment, including evaluation of the ecosystem/climate change implication of center research and evaluation of the policy implications of widespread production and utilization of bioenergy. The overall goal of this project is to develop new sustainable bioenergy-related technologies. To achieve that goal, three specific activities were supported with DOE funds: bioenergy-related research initiation projects, bioenergy research and education via support of undergraduate and graduate students, and Research Support Activities (equipment purchases, travel to attend bioenergy conferences, and seminars). Numerous research findings in diverse fields related to bioenergy were produced from these activities and are summarized in this report.

  20. Rapid guiding center calculations

    International Nuclear Information System (INIS)

    White, R.B.

    1995-04-01

    Premature loss of high energy particles, and in particular fusion alpha particles, is very deleterious in a fusion reactor. Because of this it is necessary to make long-time simulations, on the order of the alpha particle slowing down time, with a number of test particles sufficient to give predictions with reasonable statistical accuracy. Furthermore it is desirable to do this for a large number of equilibria with different characteristic magnetic field ripple, to best optimize engineering designs. In addition, modification of the particle distribution due to magnetohydrodynamic (MHD) modes such as the saw tooth mode present in the plasma can be important, and this effect requires additional simulation. Thus the large number of necessary simulations means any increase of computing speed in guiding center codes is an important improvement in predictive capability. Previous guiding center codes using numerical equilibria such as ORBIT evaluated the local field strength and ripple magnitude using Lagrangian interpolation on a grid. Evaluation of these quantities four times per time step (using a fourth order Runge-Kutta routine) constitutes the major computational effort of the code. In the present work the authors represent the field quantities through an expansion in terms of pseudo-cartesian coordinates formed from the magnetic coordinates. The simplicity of the representation gives four important advantages over previous methods

  1. Recombination luminescence from H centers and conversion of H centers into I centers in alkali iodides

    International Nuclear Information System (INIS)

    Berzina, B.J.

    1981-01-01

    The study is aimed at the search for H-plus-electron centers of luminescence and the investigation of the conversion of H- into I centers by the luminescence of H-plus-electron centers in alkali iodide crystals. KI, RbI and NaI crystals were studied at 12 K. H and F centers were created by irradiation with ultraviolet light corresponding to the absorption band of anion excitons. Then the excitation of electron centers by red light irradiation was followed. The spectra of stimulated recombination luminescence were studied. The luminescence of H-plus- electron centers had been observed and the conclusion was made that this center was formed on immobile H centers. In case of stable H centers the optically stimulated conversion of H centers into I centers occurs. The assumption is advanced on the spontaneous annihilation of near placed unstable F, H centers which leads to the creation of H-plus-electron luminescence centers and to the spontaneous H-I-centers conversion [ru

  2. Dialysis centers - what to expect

    Science.gov (United States)

    ... kidneys - dialysis centers; Dialysis - what to expect; Renal replacement therapy - dialysis centers; End-stage renal disease - dialysis ... to a tube that connects to the dialysis machine. Your blood will flow through the tube, into ...

  3. VT Designated Growth Center Boundary

    Data.gov (United States)

    Vermont Center for Geographic Information — Growth centers aim to align public infrastructure and private building investments with a local framework of policies and regulations to ensure that 20 years of...

  4. PTSD: National Center for PTSD

    Medline Plus

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  5. PTSD: National Center for PTSD

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    Full Text Available ... Special Groups Caregivers Combat Veterans & their Families Readjustment Counseling (Vet Centers) War Related Illness & Injury Study Center ... Advanced Search Where to Get Help PTSD Coach Online Tools to help you manage stress. Search Pilots ...

  6. PTSD: National Center for PTSD

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    Full Text Available ... enter to expand a main menu option (Health, Benefits, etc). 3. To enter and activate the submenu ... Numbers Locator Hospitals and Clinics Vet Centers Regional Benefits Offices Regional Loan Centers Cemetery Locations Get help ...

  7. PTSD: National Center for PTSD

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    Full Text Available ... Media Room Public Affairs News Releases Speeches Videos Publications National Observances Veterans Day Memorial Day Celebrating America's ... Providers and Clergy Co-Occurring Conditions Continuing Education Publications List of Center Publications Articles by Center Staff ...

  8. Center for Beam Physics, 1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This report contains the following information on the center for beam physics: Facilities; Organizational Chart; Roster; Profiles of Staff; Affiliates; Center Publications (1991--1993); and 1992 Summary of Activities.

  9. PTSD: National Center for PTSD

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    Full Text Available ... Locator Hospitals and Clinics Vet Centers Regional Benefits Offices Regional Loan Centers Cemetery Locations Get help from ... Resource Directory Grants Management Services Veterans Service Organizations Office of Accountability & Whistleblower Protection Transparency Media Room Inside ...

  10. National Center for Biotechnology Information

    Science.gov (United States)

    ... to NCBI Sign Out NCBI National Center for Biotechnology Information Search database All Databases Assembly Biocollections BioProject ... Search Welcome to NCBI The National Center for Biotechnology Information advances science and health by providing access ...

  11. Center for Beam Physics, 1992

    International Nuclear Information System (INIS)

    1993-06-01

    This report contains the following information on the center for beam physics: Facilities; Organizational Chart; Roster; Profiles of Staff; Affiliates; Center Publications (1991--1993); and 1992 Summary of Activities

  12. Daugherty Memorial Assessment Center (DMAC)

    Data.gov (United States)

    Federal Laboratory Consortium — Daugherty Memorial Assessment Center (DMAC) is a 39,000-square-foot facility that doubles the warfare center's high-secured performance assessment capabilities. DMAC...

  13. PTSD: National Center for PTSD

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    Full Text Available ... FAQs Ask a Question Toll Free Numbers Locator Hospitals and Clinics Vet Centers Regional Benefits Offices Regional ... TEE) Tournament Wheelchair Games Winter Sports Clinic Locations Hospitals & Clinics Vet Centers Regional Benefits Offices Regional Loan ...

  14. PTSD: National Center for PTSD

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    Full Text Available ... Community Providers and Clergy Co-Occurring Conditions Continuing Education Publications List of Center Publications Articles by Center ... Type List of Materials By Type Assessments Continuing Education Handouts Manuals Mobile Apps Publications Toolkits Videos Web ...

  15. Center for Veterinary Medicine (CVM)

    Data.gov (United States)

    Federal Laboratory Consortium — As seen on the center's logo, the mission statement for FDA's Center for Veterinary Medicine (CVM) reads: "Protecting Human and Animal Health." To achieve this broad...

  16. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Families Readjustment Counseling (Vet Centers) War Related Illness & Injury Study Center Homeless ... crisis or having thoughts of suicide, visit VeteransCrisisLine.net for more resources. Close this modal

  17. VT Designated Village Centers Boundary

    Data.gov (United States)

    Vermont Center for Geographic Information — This community revitalization program helps maintain or evolve small to medium-sized historic centers with existing civic and commercial buildings. The designation...

  18. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Search Contact Us FAQs Ask a Question Toll Free Numbers Locator Hospitals and Clinics Vet Centers Regional ... Locations Contact Us FAQs Ask a Question Toll Free Numbers VA » Health Care » PTSD: National Center for ...

  19. Italy INAF Data Center Report

    Science.gov (United States)

    Negusini, M.; Sarti, P.

    2013-01-01

    This report summarizes the activities of the Italian INAF VLBI Data Center. Our Data Center is located in Bologna, Italy and belongs to the Institute of Radioastronomy, which is part of the National Institute of Astrophysics.

  20. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... and Media Research Topics For Veterans For Researchers Research Oversight Special Groups Caregivers Combat Veterans & their Families Readjustment Counseling (Vet Centers) War Related Illness & Injury Study Center Homeless Veterans Returning Service Members Rural Veterans ...

  1. PTSD: National Center for PTSD

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    Full Text Available ... PTSD Consultation For Specific Providers VA Providers and Staff Disaster Responders Medical Doctors Community Providers and Clergy ... Publications List of Center Publications Articles by Center Staff Clinician’s Trauma Update PTSD Research Quarterly Publications Search ...

  2. PTSD: National Center for PTSD

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  3. PTSD: National Center for PTSD

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    Full Text Available ... PTSD Screens Trauma Exposure Measures Assessment Request Form List of All Measures Treatment Treatment Overview Early Intervention ... and Clergy Co-Occurring Conditions Continuing Education Publications List of Center Publications Articles by Center Staff Clinician’s ...

  4. Center for Prostate Disease Research

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Prostate Disease Research is the only free-standing prostate cancer research center in the U.S. This 20,000 square foot state-of-the-art basic science...

  5. School-Based Health Centers

    Science.gov (United States)

    ... care group, such as a community health center, hospital, or health department. A few are run by the school district itself. Centers often get money from charities and the government so they can give care ...

  6. PTSD: National Center for PTSD

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  7. PTSD: National Center for PTSD

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    Full Text Available ... Conditions Continuing Education Publications List of Center Publications Articles by Center Staff Clinician’s Trauma Update PTSD Research ... Search Tips Modify Your Search How to Obtain Articles Alerts User Guide Purpose and Scope Find Assessment ...

  8. PTSD: National Center for PTSD

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    Full Text Available ... Community Providers and Clergy Co-Occurring Conditions Continuing Education Publications List of Center Publications Articles by Center Staff Clinician’s Trauma Update PTSD Research Quarterly Publications Search ...

  9. COMPUTATIONAL SCIENCE CENTER

    International Nuclear Information System (INIS)

    DAVENPORT, J.

    2006-01-01

    Computational Science is an integral component of Brookhaven's multi science mission, and is a reflection of the increased role of computation across all of science. Brookhaven currently has major efforts in data storage and analysis for the Relativistic Heavy Ion Collider (RHIC) and the ATLAS detector at CERN, and in quantum chromodynamics. The Laboratory is host for the QCDOC machines (quantum chromodynamics on a chip), 10 teraflop/s computers which boast 12,288 processors each. There are two here, one for the Riken/BNL Research Center and the other supported by DOE for the US Lattice Gauge Community and other scientific users. A 100 teraflop/s supercomputer will be installed at Brookhaven in the coming year, managed jointly by Brookhaven and Stony Brook, and funded by a grant from New York State. This machine will be used for computational science across Brookhaven's entire research program, and also by researchers at Stony Brook and across New York State. With Stony Brook, Brookhaven has formed the New York Center for Computational Science (NYCCS) as a focal point for interdisciplinary computational science, which is closely linked to Brookhaven's Computational Science Center (CSC). The CSC has established a strong program in computational science, with an emphasis on nanoscale electronic structure and molecular dynamics, accelerator design, computational fluid dynamics, medical imaging, parallel computing and numerical algorithms. We have been an active participant in DOES SciDAC program (Scientific Discovery through Advanced Computing). We are also planning a major expansion in computational biology in keeping with Laboratory initiatives. Additional laboratory initiatives with a dependence on a high level of computation include the development of hydrodynamics models for the interpretation of RHIC data, computational models for the atmospheric transport of aerosols, and models for combustion and for energy utilization. The CSC was formed to bring together

  10. COMPUTATIONAL SCIENCE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    DAVENPORT, J.

    2006-11-01

    Computational Science is an integral component of Brookhaven's multi science mission, and is a reflection of the increased role of computation across all of science. Brookhaven currently has major efforts in data storage and analysis for the Relativistic Heavy Ion Collider (RHIC) and the ATLAS detector at CERN, and in quantum chromodynamics. The Laboratory is host for the QCDOC machines (quantum chromodynamics on a chip), 10 teraflop/s computers which boast 12,288 processors each. There are two here, one for the Riken/BNL Research Center and the other supported by DOE for the US Lattice Gauge Community and other scientific users. A 100 teraflop/s supercomputer will be installed at Brookhaven in the coming year, managed jointly by Brookhaven and Stony Brook, and funded by a grant from New York State. This machine will be used for computational science across Brookhaven's entire research program, and also by researchers at Stony Brook and across New York State. With Stony Brook, Brookhaven has formed the New York Center for Computational Science (NYCCS) as a focal point for interdisciplinary computational science, which is closely linked to Brookhaven's Computational Science Center (CSC). The CSC has established a strong program in computational science, with an emphasis on nanoscale electronic structure and molecular dynamics, accelerator design, computational fluid dynamics, medical imaging, parallel computing and numerical algorithms. We have been an active participant in DOES SciDAC program (Scientific Discovery through Advanced Computing). We are also planning a major expansion in computational biology in keeping with Laboratory initiatives. Additional laboratory initiatives with a dependence on a high level of computation include the development of hydrodynamics models for the interpretation of RHIC data, computational models for the atmospheric transport of aerosols, and models for combustion and for energy utilization. The CSC was formed to

  11. Generalized Warburg impedance on realistic self-affine fractals ...

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... We analyse the problem of impedance for a diffusion controlled charge transfer process across an irregular interface. These interfacial irregularities are characterized as two class of random fractals: (i) a statistically isotropic self-affine fractals and (ii) a statistically corrugated self-affine fractals.

  12. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.

    Science.gov (United States)

    Ward, Patrick S; Thompson, Craig B

    2012-03-20

    Cancer metabolism has long been equated with aerobic glycolysis, seen by early biochemists as primitive and inefficient. Despite these early beliefs, the metabolic signatures of cancer cells are not passive responses to damaged mitochondria but result from oncogene-directed metabolic reprogramming required to support anabolic growth. Recent evidence suggests that metabolites themselves can be oncogenic by altering cell signaling and blocking cellular differentiation. No longer can cancer-associated alterations in metabolism be viewed as an indirect response to cell proliferation and survival signals. We contend that altered metabolism has attained the status of a core hallmark of cancer. Copyright © 2012 Elsevier Inc. All rights reserved.

  13. Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

    OpenAIRE

    Ward, Patrick S.; Thompson, Craig B.

    2012-01-01

    Cancer metabolism has long been equated with aerobic glycolysis, seen by early biochemists as primitive and inefficient. Despite these early beliefs, the metabolic signatures of cancer cells are not passive responses to damaged mitochondria, but result from oncogene-directed metabolic reprogramming required to support anabolic growth. Recent evidence suggests that metabolites themselves can be oncogenic by altering cell signaling and blocking cellular differentiation. No longer can cancer-ass...

  14. Generalized Warburg impedance on realistic self-affine fractals

    Indian Academy of Sciences (India)

    We analyse the problem of impedance for a diffusion controlled charge transfer process across an irregular interface. These interfacial irregularities are characterized as two class of random fractals: (i) a statistically isotropic self-affine fractals and (ii) a statistically corrugated self-affine fractals. The information about the ...

  15. Virtual Meteorological Center

    Directory of Open Access Journals (Sweden)

    Marius Brinzila

    2007-10-01

    Full Text Available A virtual meteorological center, computer based with Internet possibility transmission of the information is presented. Circumstance data is collected with logging field meteorological station. The station collects and automatically save data about the temperature in the air, relative humidity, pressure, wind speed and wind direction, rain gauge, solar radiation and air quality. Also can perform sensors test, analyze historical data and evaluate statistical information. The novelty of the system is that it can publish data over the Internet using LabVIEW Web Server capabilities and deliver a video signal to the School TV network. Also the system performs redundant measurement of temperature and humidity and was improved using new sensors and an original signal conditioning module.

  16. Microtubule-Organizing Centers.

    Science.gov (United States)

    Wu, Jingchao; Akhmanova, Anna

    2017-10-06

    The organization of microtubule networks is crucial for controlling chromosome segregation during cell division, for positioning and transport of different organelles, and for cell polarity and morphogenesis. The geometry of microtubule arrays strongly depends on the localization and activity of the sites where microtubules are nucleated and where their minus ends are anchored. Such sites are often clustered into structures known as microtubule-organizing centers, which include the centrosomes in animals and spindle pole bodies in fungi. In addition, other microtubules, as well as membrane compartments such as the cell nucleus, the Golgi apparatus, and the cell cortex, can nucleate, stabilize, and tether microtubule minus ends. These activities depend on microtubule-nucleating factors, such as γ-tubulin-containing complexes and their activators and receptors, and microtubule minus end-stabilizing proteins with their binding partners. Here, we provide an overview of the current knowledge on how such factors work together to control microtubule organization in different systems.

  17. Interactive design center.

    Energy Technology Data Exchange (ETDEWEB)

    Pomplun, Alan R. (Sandia National Laboratories, Livermore, CA)

    2005-07-01

    Sandia's advanced computing resources provide researchers, engineers and analysts with the ability to develop and render highly detailed large-scale models and simulations. To take full advantage of these multi-million data point visualizations, display systems with comparable pixel counts are needed. The Interactive Design Center (IDC) is a second generation visualization theater designed to meet this need. The main display integrates twenty-seven projectors in a 9-wide by 3-high array with a total display resolution of more than 35 million pixels. Six individual SmartBoard displays offer interactive capabilities that include on-screen annotation and touch panel control of the facility's display systems. This report details the design, implementation and operation of this innovative facility.

  18. Center for dielectric studies

    Science.gov (United States)

    Cross, L. E.; Newnham, R. E.; Biggers, J. V.

    1984-05-01

    This report focuses upon the parts of the Center program which have drawn most extensively upon Navy funds. In the basic study of polarization processes in high K dielectrics, major progress has been made in understanding the mechanisms in relaxor ferroelectric in the perovskite structure families. A new effort is also being mounted to obtain more precise evaluation of the internal stress effects in fine grained barium titanate. Related to reliability, studies of the effects of induced macro-defects are described, and preparation for the evaluation of space charge by internal potential distribution measurements discussed. To develop new processing methods for very thin dielectric layers, a new type of single barrier layer multilayer is discussed, and work on the thermal evaporation of oriented crystalline antimony sulphur iodide describe.

  19. The satellite situation center

    International Nuclear Information System (INIS)

    Teague, M.J.; Sawyer, D.M.; Vette, J.I.

    1982-01-01

    Considerations related to the early planning for the International Magnetospheric Study (IMS) took into account the desirability of an establishment of specific entities for generating and disseminating coordination information for both retrospective and predictive periods. The organizations established include the IMS/Satellite Situation Center (IMS/SSC) operated by NASA. The activities of the SSC are related to the preparation of reports on predicted and actually achieved satellite positions, the response to inquiries, the compilation of information on satellite experiments, and the issue of periodic status summaries. Attention is given to high-altitude satellite services, other correlative satellite services, non-IMS activities of the SSC, a summary of the SSC request activity, and post-IMS and future activities

  20. Citizen centered design

    Directory of Open Access Journals (Sweden)

    Ingrid Mulder

    2015-11-01

    Full Text Available Today architecture has to design for rapidly changing futures, in a citizen-centered way. That is, architecture needs to embrace meaningful design. Societal challenges ask for a new paradigm in city-making, which combines top-down public management with bottom-up social innovation to reach meaningful design. The biggest challenge is indeed to embrace a new collaborative attitude, a participatory approach, and to have the proper infrastructure that supports this social fabric. Participatory design and transition management are future-oriented, address people and institutions. Only through understanding people in context and the corresponding dynamics, one is able to design for liveable and sustainable urban environments, embracing the human scale.

  1. Abramovo Counterterrorism Training Center

    International Nuclear Information System (INIS)

    Hayes, Christopher M.; Ross, Larry; Kaldenbach, Karen Yvonne; Estigneev, Yuri; Murievav, Andrey

    2011-01-01

    The U.S. government has been assisting the Russian Federation (RF) Ministry of Defense (MOD) for many years with nuclear weapons transportation security (NWTS) through the provision of specialized guard escort railcars and cargo railcars with integrated physical security and communication systems, armored transport vehicles, and armored escort vehicles. As a natural continuation of the NWTS program, a partnership has been formed to construct a training center that will provide counterterrorism training to personnel in all branches of the RF MOD. The Abramovo Counterterrorism Training Center (ACTC) is a multinational, multiagency project with funding from Canada, RF and the U.S. Departments of Defense and Energy. ACTC will be a facility where MOD personnel can conduct basic through advanced training in various security measures to protect Category IA material against the threat of terrorist attack. The training will enhance defense-in-depth principles by integrating MOD guard force personnel into the overall physical protection systems and improving their overall response time and neutralization capabilities. The ACTC project includes infrastructure improvements, renovation of existing buildings, construction of new buildings, construction of new training facilities, and provision of training and other equipment. Classroom training will be conducted in a renovated training building. Basic and intermediate training will be conducted on three different security training areas where various obstacles and static training devices will be constructed. The central element of ACTC, where advanced training will be held, is the 'autodrome,' a 3 km road along which various terrorist events can be staged to challenge MOD personnel in realistic and dynamic nuclear weapons transportation scenarios. This paper will address the ACTC project elements and the vision for training development and integrating this training into actual nuclear weapons transportation operations.

  2. Launch Vehicle Control Center Architectures

    Science.gov (United States)

    Watson, Michael D.; Epps, Amy; Woodruff, Van; Vachon, Michael Jacob; Monreal, Julio; Williams, Randall; McLaughlin, Tom

    2014-01-01

    This analysis is a survey of control center architectures of the NASA Space Launch System (SLS), United Launch Alliance (ULA) Atlas V and Delta IV, and the European Space Agency (ESA) Ariane 5. Each of these control center architectures have similarities in basic structure, and differences in functional distribution of responsibilities for the phases of operations: (a) Launch vehicles in the international community vary greatly in configuration and process; (b) Each launch site has a unique processing flow based on the specific configurations; (c) Launch and flight operations are managed through a set of control centers associated with each launch site, however the flight operations may be a different control center than the launch center; and (d) The engineering support centers are primarily located at the design center with a small engineering support team at the launch site.

  3. The Lathrop Wells volcanic center

    International Nuclear Information System (INIS)

    Crowe, B.; Morley, R.

    1992-01-01

    The Lathrop Wells volcanic center is located 20 km south of the potential Yucca Mountain site, at the south end of the Yucca Mountain range. This paper discusses a detailed Study Plan which was prepared describing planned geochronology and field studies to assess the chronology of the Lathrop Wells volcanic center and other Quaternary volcanic centers in the region. A paper was published discussing the geomorphic and soil evidence for a late Pleistocene or Holoceno age for the main cone of the center. The purpose of this paper was to expose the ideas concerning the age of the Lathrop Wells center to scientific scrutiny. Additionally, field evidence was described suggesting the Lathrop Wells center may have formed from multiple eruptive events with significant intervals of no activity between events. This interpretation breaks with established convention in the volcanological literature that small volume basalt centers are monogenetic

  4. The ATOMKI Accelerator Center

    International Nuclear Information System (INIS)

    Biri, S.; Kormany, Z.; Berzi, I.; Hunyadi, M.

    2009-01-01

    In 2009 a new division was established in our institute: the ATOMKI Accelerator Center (AAC). Before this time the facilities and staff of AAC belonged to other departments of the institute. The re-organization however, was necessary. It was understood that the translocation of all the accelerators into a centralized unit is advantageous in numerous fields. Here we just mention some of them. The submission of any instrumentation type proposal (EU or domestic) will be easier and has a higher chance to be supported. The organization and distribution of the beamtimes will be more equal and optimal. The usage of the maintenance and spare tools can became better and cheaper. The operating staff (cca. 20 person) can serve at more than one accelerator and the teams can help each other. The accelerator center actually became a fourth new basic unit of the institute besides the three traditional scientific divisions (see the Atomki homepage for the organization chart). The following six main facilities belong to the accelerator center: Cyclotron; VdG-5 accelerator; VdG-1 accelerator; ECR ion source; Isotope separator; Tandetron (under installation). In figure 1 the placements of these machines are shown in an artistic 3D map of the Atomki. The table 1 summarizes the main parameters of the accelerators. More detailed technical specification of the machines can be found in the new homepage of the center. In 2009 all the accelerators operated as scheduled, safely and without major breakdowns. After the experiences in the first months it can be concluded that the new center works well both for technical and human point of views. In the next sub-chapters the 2009 operation and development details of the individual accelerators are summarized. Cyclotron operation. The operation of the cyclotron in 2009 was concentrated to the usual 9 months; January, July and August were reserved for maintenance and holidays. The overall working time of the accelerator was 2009 hours; the time

  5. 'Motor control center obsolescence'

    International Nuclear Information System (INIS)

    Irish, C.S.

    2003-01-01

    A significant and growing problem within the global nuclear industry is the aging of motor control center (MCC) components. MCC's have a very important role in the safety and critical to generation requirements of a nuclear power plant. Although many OEM's MCC's such as ITE/Telemechanique, GE, Westinghouse, Cutler Hammer, Klockner Moeller, etc. have been used throughout the global nuclear industry, they all have one common aspect obsolescence. Obsolescence of various components within the MCC's such as molded case circuit breakers, starters, relays, heaters, contactors, etc. are impacting the reliability of the MCC to serve its intended function. The paper will discuss the options which the nuclear industry is faced with to increase the reliability of the MCC's while maintaining design control, qualification and meeting budget constraints. The options as listed below shall be discussed in detail with examples to enhance the readers understanding of the situation: 1) Component by component replacement: The hurdles associated with trying to find equivalent components to replace the obsolete components while still worki (mechanically and electrically) in the original cubicle will be presented. 2) Complete MCC cubicle with new internal components replacement: The process of supplying a replacement cubicle, with all new internal components and new door to replace the original cubicle will be discussed. The presentation will conclude with a comparison of the advantages and dis-advantages of the two methods to bring the MCC to an as new condition with the overall goal of increasing reliability. (author)

  6. The DESY Research Center

    International Nuclear Information System (INIS)

    Waloschek, P.

    1988-01-01

    On November 12, 1964, the 6 GeV electrons synchrotron and the associated utility facilities were dedicated for regular operation. Since that date, the DESY Research Center, the German Electron Synchrotron in Hamburg, has offered to scientists from all over the world unique facilities in which to study the smallest constituents of matter. At present, some 580 physicists participate in DESY's research work on particle physics and high energy physics. Most of them are university teachers, a great many come from abroad. Their home institutions make considerable contributions to setting up the measuring equipment. Another 500 physicists annually make use of the extensive synchrotron radiation facilities available at DESY. DESY is one of the thirteen national research laboratories in the Federal Republic of Germany; its annual government grants for operation and personnel (1300 staff members in 1988) amount to some DM 150 million. In addition, some DM 950 million will be invested into the construction of the new HERA facility between 1984 and 1990, of which 15% will be contributed by foreign institutions. The ordinary budget of DESY is paid 90% by the German Federal Ministry for Research and Technology (BMFT) and 10% by the city of Hamburg. (orig.)

  7. Space Operations Learning Center

    Science.gov (United States)

    Lui, Ben; Milner, Barbara; Binebrink, Dan; Kuok, Heng

    2012-01-01

    The Space Operations Learning Center (SOLC) is a tool that provides an online learning environment where students can learn science, technology, engineering, and mathematics (STEM) through a series of training modules. SOLC is also an effective media for NASA to showcase its contributions to the general public. SOLC is a Web-based environment with a learning platform for students to understand STEM through interactive modules in various engineering topics. SOLC is unique in its approach to develop learning materials to teach schoolaged students the basic concepts of space operations. SOLC utilizes the latest Web and software technologies to present this educational content in a fun and engaging way for all grade levels. SOLC uses animations, streaming video, cartoon characters, audio narration, interactive games and more to deliver educational concepts. The Web portal organizes all of these training modules in an easily accessible way for visitors worldwide. SOLC provides multiple training modules on various topics. At the time of this reporting, seven modules have been developed: Space Communication, Flight Dynamics, Information Processing, Mission Operations, Kids Zone 1, Kids Zone 2, and Save The Forest. For the first four modules, each contains three components: Flight Training, Flight License, and Fly It! Kids Zone 1 and 2 include a number of educational videos and games designed specifically for grades K-6. Save The Forest is a space operations mission with four simulations and activities to complete, optimized for new touch screen technology. The Kids Zone 1 module has recently been ported to Facebook to attract wider audience.

  8. Energy Efficiency Center - Overview

    International Nuclear Information System (INIS)

    Obryk, E.

    2000-01-01

    Full text: The Energy Efficiency Center (EEC) activities have been concentrated on Energy Efficiency Network (SEGE), education and training of energy auditors. EEC has started studies related to renewable fuels (bio fuel, wastes) and other topics related to environment protection. EEC has continued close collaboration with Institute for Energy Technology, Kjeller, Norway. It has been organized and conducted Seminar and Workshop on ''How to Reduce Energy and Water Cost in Higher Education Buildings'' for general and technical managers of the higher education institutions. This Seminar was proceeded by the working meeting on energy efficiency strategy in higher education at the Ministry of National Education. EEC has worked out proposal for activities of Cracow Regional Agency for Energy Efficiency and Environment and has made offer to provide services for this Agency in the field of training, education and consulting. The vast knowledge and experiences in the field of energy audits have been used by the members of EEC in lecturing at energy auditors courses authorized by the National Energy Efficiency Agency (KAPE). Altogether 20 lectures have been delivered. (author)

  9. Satellite medical centers project

    Science.gov (United States)

    Aggarwal, Arvind

    2002-08-01

    World class health care for common man at low affordable cost: anywhere, anytime The project envisages to set up a national network of satellite Medical centers. Each SMC would be manned by doctors, nurses and technicians, six doctors, six nurses, six technicians would be required to provide 24 hour cover, each SMC would operate 24 hours x 7 days. It would be equipped with the Digital telemedicine devices for capturing clinical patient information and investigations in the form of voice, images and data and create an audiovisual text file - a virtual Digital patient. Through the broad band connectivity the virtual patient can be sent to the central hub, manned by specialists, specialists from several specialists sitting together can view the virtual patient and provide a specialized opinion, they can see the virtual patient, see the examination on line through video conference or even PCs, talk to the patient and the doctor at the SMC and controlle capturing of information during examination and investigations of the patient at the SMC - thus creating a virtual Digital consultant at the SMC. Central hub shall be connected to the doctors and consultants in remote locations or tertiary care hospitals any where in the world, thus creating a virtual hub the hierarchical system shall provide upgradation of knowledge to thedoctors in central hub and smc and thus continued medical education and benefit the patient thru the world class treatment in the smc located at his door step. SMC shall be set up by franchisee who shall get safe business opportunity with high returns, patients shall get Low cost user friendly worldclass health care anywhere anytime, Doctors can get better meaningful selfemplyment with better earnings, flexibility of working time and place. SMC shall provide a wide variety of services from primary care to world class Global consultation for difficult patients.

  10. Production and Distribution Research Center

    Science.gov (United States)

    1986-05-01

    Steel, Coca Cola , Standard Oil of Ohio, and Martin Marietta have been involved in joint research with members of the Center. The number of Faculty...permitted the establishment of the Center and supports its continuing development. The Center has also received research sponsorship from the Joint...published relating to results developed within the PDRC under Offce of Naval Research sponsorship . These reports are listed in Appendix A. Many of these

  11. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Immunizations Flu Vaccination Prevention / Wellness Public Health Weight Management (MOVE!) Locations Hospitals & Clinics Vet Centers Veterans Canteen Service (VCS) Research ...

  12. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Performance VA Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report ... Management Services Veterans Service Organizations Office of Accountability & Whistleblower ...

  13. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act ... Management Services Veterans Service Organizations Office of Accountability & Whistleblower ...

  14. Center for Rehabilitation Sciences Research

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Rehabilitation Sciences Research (CRSR) was established as a research organization to promote successful return to duty and community reintegration of...

  15. Center for Environmental Health Sciences

    Data.gov (United States)

    Federal Laboratory Consortium — The primary research objective of the Center for Environmental Health Sciences (CEHS) at the University of Montana is to advance knowledge of environmental impacts...

  16. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget ... Events Adaptive Sports Program Creative Arts Festival Golden Age Games Summer ...

  17. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... and Media Research Topics For Veterans For Researchers Research Oversight Special Groups Caregivers Combat Veterans & their Families Readjustment Counseling (Vet Centers) War Related Illness & Injury ...

  18. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Type List of Materials By Type Assessments Continuing Education Handouts Manuals Mobile Apps Publications Toolkits Videos Web Links Advanced Search About Us National Center ...

  19. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Organizations History Budget and Performance VA Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business ...

  20. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget ... Management Services Veterans Service Organizations Office of Accountability & Whistleblower ...

  1. Energetics Manufacturing Technology Center (EMTC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Energetics Manufacturing Technology Center (EMTC), established in 1994 by the Office of Naval Research (ONR) Manufacturing Technology (ManTech) Program, is Navy...

  2. Bistable amphoteric centers in semiconductors

    International Nuclear Information System (INIS)

    Nikitina, A. G.; Zuev, V. V.

    2008-01-01

    It is shown that, at thermodynamic equilibrium, the release of charge carriers from the localized states of bistable amphoteric centers into quasi-free states depends on the degree of compensation. This brings about different functional dependences of the concentration of free charge carriers on temperature. It is found that, in uncompensated semiconductors, the concentration of free charge carriers follows the same dependence in the case of bistable amphoteric centers and bistable amphoteric U - centers, although the distributions of charge carriers over the charge states and configurations are different for these types of centers. The results can be used for interpreting various experimental data insufficiently explained in the context of the traditional approach

  3. Center for Neuroscience & Regenerative Medicine

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Neuroscience and Regenerative Medicine (CNRM) was established as a collaborative intramural federal program involving the U.S. Department of Defense...

  4. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business Congressional Affairs Jobs Benefits Booklet Data & Statistics ...

  5. PTSD: National Center for PTSD

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    Full Text Available ... Immunizations Flu Vaccination Prevention / Wellness Public Health Weight Management (MOVE!) Locations Hospitals & Clinics Vet Centers Veterans Canteen Service (VCS) Research Research ...

  6. PTSD: National Center for PTSD

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    Full Text Available ... Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business Congressional Affairs Jobs Benefits Booklet Data & Statistics VA ...

  7. Consolidated Copayment Processing Center (CCPC)

    Data.gov (United States)

    Department of Veterans Affairs — The Consolidated Copayment Processing Center (CCPC) database contains Veteran patient contact and billing information in order to support the printing and mailing of...

  8. Clean Energy Application Center

    Energy Technology Data Exchange (ETDEWEB)

    Freihaut, Jim [Pennsylvania State Univ., University Park, PA (United States)

    2013-09-30

    The Mid Atlantic Clean Energy Application Center (MACEAC), managed by The Penn State College of Engineering, serves the six states in the Mid-Atlantic region (Pennsylvania, New Jersey, Delaware, Maryland, Virginia and West Virginia) plus the District of Columbia. The goals of the Mid-Atlantic CEAC are to promote the adoption of Combined Heat and Power (CHP), Waste Heat Recovery (WHR) and District Energy Systems (DES) in the Mid Atlantic area through education and technical support to more than 1,200 regional industry and government representatives in the region. The successful promotion of these technologies by the MACEAC was accomplished through the following efforts; (1)The MACEAC developed a series of technology transfer networks with State energy and environmental offices, Association of Energy Engineers local chapters, local community development organizations, utilities and, Penn State Department of Architectural Engineering alumni and their firms to effectively educate local practitioners about the energy utilization, environmental and economic advantages of CHP, WHR and DES; (2) Completed assessments of the regional technical and market potential for CHP, WHR and DE technologies application in the context of state specific energy prices, state energy and efficiency portfolio development. The studies were completed for Pennsylvania, New Jersey and Maryland and included a set of incentive adoption probability models used as a to guide during implementation discussions with State energy policy makers; (3) Using the technical and market assessments and adoption incentive models, the Mid Atlantic CEAC developed regional strategic action plans for the promotion of CHP Application technology for Pennsylvania, New Jersey and Maryland; (4) The CHP market assessment and incentive adoption model information was discussed, on a continuing basis, with relevant state agencies, policy makers and Public Utility Commission organizations resulting in CHP favorable incentive

  9. Techbelt Energy Innovation Center

    Energy Technology Data Exchange (ETDEWEB)

    Marie, Hazel [Youngstown State Univ., OH (United States); Nestic, Dave [TechBelt Energy Innovation Center, Warren, OH (United States); Hripko, Michael [Youngstown State Univ., OH (United States); Abraham, Martin [Youngstown State Univ., OH (United States)

    2017-06-30

    This project consisted of three main components 1) The primary goal of the project was to renovate and upgrade an existing commercial building to the highest possible environmentally sustainable level for the purpose of creating an energy incubator. This initiative was part of the Infrastructure Technologies Program, through which a sustainable energy demonstration facility was to be created and used as a research and community outreach base for sustainable energy product and process incubation; 2) In addition, fundamental energy related research on wind energy was performed; a shrouded wind turbine on the Youngstown State University campus was commissioned; and educational initiatives were implemented; and 3) The project also included an education and outreach component to inform and educate the public in sustainable energy production and career opportunities. Youngstown State University and the Tech Belt Energy Innovation Center (TBEIC) renovated a 37,000 square foot urban building which is now being used as a research and development hub for the region’s energy technology innovation industry. The building houses basic research facilities and business development in an incubator format. In addition, the TBEIC performs community outreach and education initiatives in advanced and sustainable energy. The building is linked to a back warehouse which will eventually be used as a build-out for energy laboratory facilities. The projects research component investigated shrouded wind turbines, and specifically the “Windcube” which was renamed the “Wind Sphere” during the course of the project. There was a specific focus on the development in the theory of shrouded wind turbines. The goal of this work was to increase the potential efficiency of wind turbines by improving the lift and drag characteristics. The work included computational modeling, scale models and full-sized design and construction of a test turbine. The full-sized turbine was built on the YSU

  10. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available skip to page content Attention A T users. To access the menus on this page please perform the following steps. 1. Please switch auto forms ... Conditions Continuing Education Publications List of Center Publications Articles by Center Staff Clinician’s Trauma Update PTSD Research ...

  11. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Section Home PTSD Overview PTSD Basics Return from War Specific to Women Types of Trauma War Terrorism Violence and Abuse Disasters Is it PTSD? ... Combat Veterans & their Families Readjustment Counseling (Vet Centers) War Related Illness & Injury Study Center Homeless Veterans Returning ...

  12. Person-Centered Transition Planning.

    Science.gov (United States)

    Miner, Craig A.; Bates, Paul E.

    1997-01-01

    Describes a person-centered planning approach for involving students with disabilities and their families in the transition planning process. Components of person-centered planning are discussed, including development of a personal profile, identification of future lifestyle preferences, action steps and responsible parties, and necessary changes…

  13. Potential energy center site investigations

    International Nuclear Information System (INIS)

    Savage, W.F.

    1977-01-01

    Past studies by the AEC, NRC, NSF and others have indicated that energy centers have certain advantages over dispersed siting. There is the need, however, to investigate such areas as possible weather modifications due to major heat releases, possible changes in Federal/state/local laws and institutional arrangements to facilitate implementation of energy centers, and to assess methods of easing social and economic pressures on a surrounding community due to center construction. All of these areas are under study by ERDA, but there remains the major requirement for the study of a potential site to yield a true assessment of the energy center concept. In this regard the Division of Nuclear Research and Applications of ERDA is supporting studies by the Southern and Western Interstate Nuclear Boards to establish state and utility interest in the concept and to carry out screening studies of possible sites. After selection of a final site for center study , an analysis will be made of the center including technical areas such as heat dissipation methods, water resource management, transmission methods, construction methods and schedules, co-located fuel cycle facilities, possible mix of reactor types, etc. Additionally, studies of safeguards, the interaction of all effected entities in the siting, construction, licensing and regulation of a center, labor force considerations in terms of local impact, social and economic changes, and financing of a center will be conducted. It is estimated that the potential site study will require approximately two years

  14. Climate Prediction Center - Seasonal Outlook

    Science.gov (United States)

    Weather Service NWS logo - Click to go to the NWS home page Climate Prediction Center Site Map News Forecast Discussion PROGNOSTIC DISCUSSION FOR MONTHLY OUTLOOK NWS CLIMATE PREDICTION CENTER COLLEGE PARK MD INFLUENCE ON THE MONTHLY-AVERAGED CLIMATE. OUR MID-MONTH ASSESSMENT OF LOW-FREQUENCY CLIMATE VARIABILITY IS

  15. Acoustic Center or Time Origin?

    DEFF Research Database (Denmark)

    Staffeldt, Henrik

    1999-01-01

    The paper discusses the acoustic center in relation to measurements of loudspeaker polar data. Also, it presents the related concept time origin and discusses the deviation that appears between positions of the acoustic center found by wavefront based and time based measuring methods....

  16. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Section Home PTSD Overview PTSD Basics Return from War Specific to Women Types of Trauma War Terrorism Violence and Abuse Disasters Is it PTSD? ... Community Providers and Clergy Co-Occurring Conditions Continuing Education Publications List of Center Publications Articles by Center ...

  17. PTSD: National Center for PTSD

    Science.gov (United States)

    ... Care » PTSD: National Center for PTSD » Public » Videos PTSD: National Center for PTSD Menu Menu PTSD PTSD Home For the Public ... Prescribing for PTSD, Know Your Options . × What is PTSD? Right Click here to download "What is PTSD?" ( ...

  18. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Care » PTSD: National Center for PTSD » Public » Videos PTSD: National Center for PTSD Menu Menu PTSD PTSD Home For the Public ... Prescribing for PTSD, Know Your Options . × What is PTSD? Right Click here to download "What is PTSD?" ( ...

  19. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Community Providers and Clergy Co-Occurring Conditions Continuing Education Publications List of Center Publications Articles by Center Staff Clinician’s Trauma Update PTSD Research Quarterly Publications Search Using the PILOTS Database What is PILOTS? Quick Search Tips Modify ...

  20. Improving Productivity via QWL Centers.

    Science.gov (United States)

    Bentley, Marion T.; Hansen, Gary B.

    1980-01-01

    Gives a brief history of productivity improvement legislation in the United States and of the development and demise of the National Center for Productivity and Quality of Working Life (QWL). Describes existing productivity and QWL centers, including their locations, scope, services, and activities, and urges greater support at the federal level.…

  1. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Community Providers and Clergy Co-Occurring Conditions Continuing Education Publications List of Center Publications Articles by Center Staff ... Type List of Materials By Type Assessments Continuing Education Handouts Manuals Mobile Apps Publications Toolkits Videos Web Links Advanced Search About Us ...

  2. Head Start Center Design Guide.

    Science.gov (United States)

    Administration for Children, Youth, and Families (DHHS), Washington, DC. Head Start Bureau.

    This guide contains suggested criteria for planning, designing, and renovating Head Start centers so that they are safe, child-oriented, developmentally appropriate, beautiful, environmentally sensitive, and functional. The content is based on the U.S. General Services Administration's Child Care Center Design Guide, PBS-P140, which was intended…

  3. Spherical Torus Center Stack Design

    International Nuclear Information System (INIS)

    C. Neumeyer; P. Heitzenroeder; C. Kessel; M. Ono; M. Peng; J. Schmidt; R. Woolley; I. Zatz

    2002-01-01

    The low aspect ratio spherical torus (ST) configuration requires that the center stack design be optimized within a limited available space, using materials within their established allowables. This paper presents center stack design methods developed by the National Spherical Torus Experiment (NSTX) Project Team during the initial design of NSTX, and more recently for studies of a possible next-step ST (NSST) device

  4. Spatial Distribution of Market Centers

    Directory of Open Access Journals (Sweden)

    Md. Morshedul Islam

    2018-03-01

    Full Text Available The present study is an attempt to find the location pattern, distribution and their sphere of influences of market centers in Rangpur City Corporation, Bangladesh. Rangpur is facing some problems like a traffic jam, noisy environment, population pressure etc due to the over population in full day long in the center of this city, all of the whole sale and retail sale markets are located in the middle. Location of Market is always influencing the daily life of the city population who are directly or indirectly connected with the market. If the market strategically distributed in an area they don’t face such kind of problems. Analysis or investigation shows that at about all of the market centers are located in the center of Rangpur and in the residential area of Rangpur. The maximum 67% market centers are found in the high-income residential area. Rangpur City Corporation, Bangladesh Bureau of Statistics and survey of Bangladesh provided the maps, reports and relevant documents of the study. The spatial dispersion pattern of market centers is clustered together at one place 0.33(Nearest Neighbor Index value, R found in the study area. Geographical Information System (GIS and other software also used to analyze the maps and diagrams. Investigation refers that, the market of Rangpur city have a clustered pattern and different levels of market centers found on the bases of centrality scores. By this centrality scores or levels, found the variation of influencing spheres of market centers in Rangpur City.

  5. Allegheny County Kane Regional Center Census

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Total number of residents in each Kane Regional Center facility by race and gender. The Kane Regional Centers are skilled nursing and rehabilitation centers run by...

  6. Pengembangan Model Manajemen ICT Center

    Directory of Open Access Journals (Sweden)

    Hakkun Elmunsyah

    2013-01-01

    Full Text Available Abstrak: Pengembangan Model Manajemen ICT Center. Kemendiknas telah melakukan investasi  cukup besar berupa pembangunan Jejaring komputer pendidikan nasional yang disebut Jaringan Pendidikan Nasional (Jardiknas, pada sekolah menengah kejuruan (SMK di seluruh Indonesia yang dikenal dengan nama ICT center. Penelitian ini bertujuan untuk menemukan model manajemen ICT center sesuai karakteristik SMK sehingga dapat memberikan kontribusi mutu pada SMK tersebut. Penelitian ini merupakan penelitian pengembangan atau Research and Development yang dikembangkan oleh Borg and Gall. Hasil secara keseluruhan penelitian menunjukkan berdasarkan uji coba keefektivan kinerja manajemen pada skala terbatas dan lebih luas menunjukkan bahwa model manajemen ICT center memenuhi kriteria sangat efektif. Kata-kata kunci: Jardiknas, SMK, model manajemen ICT center, kontribusi mutu

  7. Aerial view of the Kennedy Space Center Visitor Center

    Science.gov (United States)

    1998-01-01

    The Kennedy Space Center Visitor Center, shown in this aerial view looking south, sprawls across 70 acres on Florida's Space Coast , and is located off State Road 405, NASA Parkway, six miles inside the Space Center entrance. SR 405 can be seen at the bottom of the photo. Just above the roadway, from left can be seen the Shuttle/Gantry mockup; the Post Show Dome; the Astronaut Memorial; and to the far right, the Center for Space Education. Behind the Memorial are a cluster of buildings that include the Theater Complex, Cafeteria, Space Flight Exhibit Building, Souvenir Sales Building, Spaceport Central, and Ticket Pavilion. At the upper right are various rockets that have played a significant role in the growth of the space program.

  8. Emergency Operations Center ribbon cutting

    Science.gov (United States)

    2009-01-01

    Center Director Gene Goldman and special guests celebrate the opening of the site's new Emergency Operations Center on June 2. Participants included (l t r): Steven Cooper, deputy director of the National Weather Service Southern Region; Tom Luedtke, NASA associate administrator for institutions and management; Charles Scales, NASA associate deputy administrator; Mississippi Gov. Haley Barbour; Gene Goldman, director of Stennis Space Center; Jack Forsythe, NASA assistant administrator for the Office of Security and Program Protection; Dr. Richard Williams, NASA chief health and medical officer; and Weldon Starks, president of Starks Contracting Company Inc. of Biloxi.

  9. Human-Centered Design Capability

    Science.gov (United States)

    Fitts, David J.; Howard, Robert

    2009-01-01

    For NASA, human-centered design (HCD) seeks opportunities to mitigate the challenges of living and working in space in order to enhance human productivity and well-being. Direct design participation during the development stage is difficult, however, during project formulation, a HCD approach can lead to better more cost-effective products. HCD can also help a program enter the development stage with a clear vision for product acquisition. HCD tools for clarifying design intent are listed. To infuse HCD into the spaceflight lifecycle the Space and Life Sciences Directorate developed the Habitability Design Center. The Center has collaborated successfully with program and project design teams and with JSC's Engineering Directorate. This presentation discusses HCD capabilities and depicts the Center's design examples and capabilities.

  10. Shopping Malls - ShoppingCenters

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Collected from a variety of sources both commercial and internal, this layer represents shopping center locations within Volusia County and is maintained by the...

  11. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Polytrauma Rehabilitation Spinal Cord Injury Telehealth Womens Health Issues Wellness Programs MyHealtheVet Nutrition Quitting Smoking Vaccines & Immunizations Flu Vaccination Prevention / Wellness Public Health Weight Management (MOVE!) Locations Hospitals & Clinics Vet Centers Veterans Canteen ...

  12. Center for Worker's Compensation Studies

    Data.gov (United States)

    Federal Laboratory Consortium — The mission of the NIOSH Center for Workers’ Compensation Studies (CWCS) is to use workers’ compensation data and systems to improve workplace safety and health....

  13. PTSD: National Center for PTSD

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    Full Text Available ... America's Freedoms Special Events Adaptive Sports Program Creative Arts Festival Golden Age Games Summer Sports Clinic Training - Exposure - Experience (TEE) Tournament Wheelchair Games Winter Sports Clinic Locations Hospitals & Clinics Vet Centers Regional Benefits Offices Regional Loan ...

  14. PTSD: National Center for PTSD

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    Full Text Available ... Espanol Apps, Videos and More Mobile Apps Videos Web Links PTSD Site Search For Professionals Professional Section ... Education Handouts Manuals Mobile Apps Publications Toolkits Videos Web Links Advanced Search About Us National Center for ...

  15. PTSD: National Center for PTSD

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    Full Text Available ... by Center Staff Clinician’s Trauma Update PTSD Research Quarterly Publications Search Using the PILOTS Database What is ... Advisory Boards History and Achievements Divisions and Staff Leadership Divisions Executive Behavioral Science Clinical Neurosciences Dissemination & Training ...

  16. PTSD: National Center for PTSD

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    Full Text Available ... Performance VA Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business Congressional Affairs Jobs Benefits Booklet Data & Statistics VA Open Data VA App Store National Resource Directory Grants ...

  17. PTSD: National Center for PTSD

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    Full Text Available ... Performance VA Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery ... and Coping Treatment Self-Help and Coping PTSD Research Where to Get Help for PTSD Help with ...

  18. Engineering Technical Support Center (ETSC)

    Science.gov (United States)

    ETSC is EPA’s technical support and resource centers responsible for providing specialized scientific and engineering support to decision-makers in the Agency’s ten regional offices, states, communities, and local businesses.

  19. Records Center Program Billing System

    Data.gov (United States)

    National Archives and Records Administration — RCPBS supports the Records center programs (RCP) in producing invoices for the storage (NARS-5) and servicing of National Archives and Records Administration’s...

  20. PTSD: National Center for PTSD

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    Full Text Available ... Publications Toolkits Videos Web Links Advanced Search About Us National Center for PTSD What We Do Mission and Overview Goals and Objectives Looking Ahead Annual Reports Research Initiatives Education Initiatives Advisory Boards History and Achievements Divisions and ...

  1. Transportation Research & Analysis Computing Center

    Data.gov (United States)

    Federal Laboratory Consortium — The technical objectives of the TRACC project included the establishment of a high performance computing center for use by USDOT research teams, including those from...

  2. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business Congressional Affairs Jobs Benefits Booklet Data & Statistics VA Open Data VA App Store National Resource Directory Grants ...

  3. PTSD: National Center for PTSD

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    Full Text Available ... Performance VA Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery ... Crisis Line: 1-800-273-8255 (Press 1) Social Media Complete Directory EMAIL UPDATES Email Address Required ...

  4. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... and Coping Treatment Self-Help and Coping PTSD Research Where to Get Help for PTSD Help with ... Articles by Center Staff Clinician’s Trauma Update PTSD Research Quarterly Publications Search Using the PILOTS Database What ...

  5. Electricity Infrastructure Operations Center (EIOC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Electricity Infrastructure Operations Center (EIOC) at PNNL brings together industry-leading software, real-time grid data, and advanced computation into a fully...

  6. PTSD: National Center for PTSD

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    Full Text Available ... Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources ... Job with VA Health Care Jobs (VA Careers) Travel Nurses Get Job Help Vets in the Workplace ...

  7. PTSD: National Center for PTSD

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    Full Text Available ... Data VA App Store National Resource Directory Grants Management Services Veterans Service Organizations Office of Accountability & Whistleblower ... Immunizations Flu Vaccination Prevention / Wellness Public Health Weight Management (MOVE!) Locations Hospitals & Clinics Vet Centers Veterans Canteen ...

  8. Africa Center for Strategic Studies

    National Research Council Canada - National Science Library

    2000-01-01

    The Africa Center for Strategic Studies supports democratic governance in Africa by offering senior African civilian and military leaders a rigorous academic and practical program in civil-military...

  9. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources ... Crisis Line: 1-800-273-8255 (Press 1) Social Media Complete Directory EMAIL UPDATES Email Address Required ...

  10. PTSD: National Center for PTSD

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    Full Text Available ... Executive Biographies Organizations History Budget and Performance VA Plans, Budget, & Performance VA Center for Innovation (VACI) Agency ... Applications VA Forms State and Local Resources Strat Plan FY 2014-2020 VA Plans, Budget, & Performance VA ...

  11. PTSD: National Center for PTSD

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    Full Text Available ... For Veterans For Researchers Research Oversight Special Groups Caregivers Combat Veterans & their Families Readjustment Counseling (Vet Centers) ... Professional Section: Prescribing for PTSD, Know Your Options . × What is PTSD? Right Click here to download "What ...

  12. PTSD: National Center for PTSD

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    Full Text Available ... Immunizations Flu Vaccination Prevention / Wellness Public Health Weight Management (MOVE!) Locations Hospitals & Clinics Vet Centers Veterans Canteen Service (VCS) Research Research Home About VA Research Services Programs News, Events and Media Research Topics For Veterans For Researchers ...

  13. PTSD: National Center for PTSD

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    Full Text Available ... Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business ... Search Where to Get Help PTSD Coach Online Tools to help you manage stress. Search Pilots Search ...

  14. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... the following steps. 1. Please switch auto forms mode to off. 2. Hit enter to expand a ... Performance VA Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery ...

  15. PTSD: National Center for PTSD

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    Full Text Available ... a VA Appointment Crisis Prevention Mental Health PTSD Public Health Veterans Access, Choice & Accountability Act Benefits General Benefits ... Quitting Smoking Vaccines & Immunizations Flu Vaccination Prevention / Wellness Public Health Weight Management (MOVE!) Locations Hospitals & Clinics Vet Centers ...

  16. National Center on Elder Abuse

    Science.gov (United States)

    ... Research Synthesize and disseminate high quality research on elder abuse to encourage the translation of research into practice. ... to further the field for those interested in elder abuse identification and prevention. What’s Happening National Center on ...

  17. Clean Energy Solutions Center Services

    Energy Technology Data Exchange (ETDEWEB)

    2016-03-01

    The Solutions Center offers no-cost expert policy assistance, webinars and training forums, clean energy policy reports, data, and tools provided in partnership with more than 35 leading international and regional clean energy organizations.

  18. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Executive Biographies Organizations History Budget and Performance VA Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business Congressional Affairs Jobs Benefits Booklet Data & Statistics VA ...

  19. FEMA Disaster Recovery Centers - KML

    Data.gov (United States)

    Department of Homeland Security — This is a KML file for FEMA's Disaster Recovery Centers (DRC). A DRC is a readily accessible facility or mobile office set up by FEMA where applicants may go for...

  20. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Home Apply for VA Care Apply Online Application Process Veteran Eligibility Active Duty Families of Veterans Women ... Immunizations Flu Vaccination Prevention / Wellness Public Health Weight Management (MOVE!) Locations Hospitals & Clinics Vet Centers Veterans Canteen ...

  1. PTSD: National Center for PTSD

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    Full Text Available ... Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business Congressional ... Trauma Assessment Assessment Overview Adult Interviews Adult Self Report Child Measures Deployment Measures DSM-5 Measures PTSD ...

  2. PTSD: National Center for PTSD

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    Full Text Available ... Website Site Map Content Inventory Accessibility Privacy and Security Updating of Web Site Web Site Policies Important ... Immunizations Flu Vaccination Prevention / Wellness Public Health Weight Management (MOVE!) Locations Hospitals & Clinics Vet Centers Veterans Canteen ...

  3. Classification of Security Operation Centers

    CSIR Research Space (South Africa)

    Jacobs, P

    2013-08-01

    Full Text Available Security Operation Centers (SOCs) are a necessary service for organisations that want to address compliance and threat management. While there are frameworks in existence that addresses the technology aspects of these services, a holistic framework...

  4. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... of VA Executive Biographies Organizations History Budget and Performance VA Plans, Budget, & Performance VA Center for Innovation ( ... America's Freedoms Special Events Adaptive Sports Program Creative Arts Festival Golden Age Games Summer Sports Clinic Training - ...

  5. National Center for Health Statistics

    Science.gov (United States)

    ... Submit Search the CDC National Center for Health Statistics Note: Javascript is disabled or is not supported ... Survey of Family Growth Vital Records National Vital Statistics System National Death Index Vital Statistics Rapid Release ...

  6. PTSD: National Center for PTSD

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    Full Text Available ... Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business ... Search How to Obtain Articles Alerts User Guide Purpose and Scope Find Assessment Measures Instrument Authority List ...

  7. PTSD: National Center for PTSD

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    Full Text Available ... Adaptive Sports Program Creative Arts Festival Golden Age Games Summer Sports Clinic Training - Exposure - Experience (TEE) Tournament Wheelchair Games Winter Sports Clinic Locations Hospitals & Clinics Vet Centers ...

  8. PTSD: National Center for PTSD

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    Full Text Available ... Resources Business Congressional Affairs Jobs Benefits Booklet Data & Statistics VA Open Data VA App Store National Resource ... Manuals Mobile Apps Publications Toolkits Videos Web Links Advanced Search About Us National Center for PTSD What ...

  9. PTSD: National Center for PTSD

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    Full Text Available ... The National Center for PTSD does not provide direct clinical care, individual referrals or benefits information. For ... Minority Veterans Plain Language Surviving Spouses & Dependents Adaptive Sports Program ADMINISTRATION Veterans Health Administration Veterans Benefits Administration ...

  10. CENTER FOR CYBER SECURITY STUDIES

    Data.gov (United States)

    Federal Laboratory Consortium — The mission of the Center for Cyber Security Studies is to enhance the education of midshipmen in all areas of cyber warfare, to facilitate the sharing of expertise...

  11. Poison control center - emergency number

    Science.gov (United States)

    For a POISON EMERGENCY call: 1-800-222-1222 ANYWHERE IN THE UNITED STATES This national hotline number will let you ... is a free and confidential service. All local poison control centers in the United States use this ...

  12. Italy INAF Analysis Center Report

    Science.gov (United States)

    Negusini, M.; Sarti, P.

    2013-01-01

    This report summarizes the activity of the Italian INAF VLBI Analysis Center. Our Analysis Center is located in Bologna, Italy and belongs to the Institute of Radioastronomy, which is part of the National Institute of Astrophysics. IRA runs the observatories of Medicina and Noto, where two 32-m VLBI AZ-EL telescopes are situated. This report contains the AC's VLBI data analysis activities and shortly outlines the investigations into the co-locations of space geodetic instruments.

  13. Design of Shanghai irradiation center

    International Nuclear Information System (INIS)

    Chen Fugen; Lu Zhongwen; Xue Xiangrong; Yao Zewu; Du Bende; Xu Zhicheng; Du Kangsen

    1988-01-01

    Shanghai Irradiation Center, situated in westrn suburb of Shanghai, was completed in August, 1986. At present, a 6.55 x 10 15 Bq 60 Co source has been loaded, though the designed activity of maximum loading is 18.5 x 10 10 Bq. the center is designed mainly for irradiation preservation of food and sterilization of medical devices and tools. Its processing ability is 10 t/h for potatoes

  14. User-Centered Data Management

    CERN Document Server

    Catarci, Tiziana; Kimani, Stephen

    2010-01-01

    This lecture covers several core issues in user-centered data management, including how to design usable interfaces that suitably support database tasks, and relevant approaches to visual querying, information visualization, and visual data mining. Novel interaction paradigms, e.g., mobile and interfaces that go beyond the visual dimension, are also discussed. Table of Contents: Why User-Centered / The Early Days: Visual Query Systems / Beyond Querying / More Advanced Applications / Non-Visual Interfaces / Conclusions

  15. The Comparison between Teacher Centered and Student Centered Educational Methods

    Directory of Open Access Journals (Sweden)

    M Anvar

    2009-02-01

    Full Text Available Background and Purpose: Various approaches to learning are suggested & practiced. The traditional medical education were more teacher centered oriented . In this method the students’ involvement in the process of learning is not remarkable, but the new approach to medical education supports the students involvement. This study evaluated the various method of lecturing considering students involvements.Methods: One hundred two first year medical and nursing students involved in this study and their opinion about these two methods of learning were obtained by filling of a questionnaire. The subject of the lectures was “general psychology” which was carried out 50% by the students and 50% by the teacher. The statistical analysis was carried out by SPSS program.Results: Considering students opinion in student-centered method the various aspect of learning such as mutual understanding, use of textbooks and references were significantly increased , whereasother aspects of learning such as self esteem, study time, innovation, and study attitude though were improved, but were not significant as compared with teacher centered method. In teacher-centeredmethod the understanding of the subjects was significantly increased .Other aspects of learning such as motivation and concentration were improved but not significantly as compared with studentcentered method.Conclusion: As the result showed student centered method was favored in several aspects of learning while in teacher centered method only understanding of the subject was better . Careful choice of teaching method to provide a comprehensive learning experience should take into account these differences.Key words: TEACHER CENTERED, STUDENT CENTERED, LEARNING

  16. Techniques for evaluating optimum data center operation

    Science.gov (United States)

    Hamann, Hendrik F.; Rodriguez, Sergio Adolfo Bermudez; Wehle, Hans-Dieter

    2017-06-14

    Techniques for modeling a data center are provided. In one aspect, a method for determining data center efficiency is provided. The method includes the following steps. Target parameters for the data center are obtained. Technology pre-requisite parameters for the data center are obtained. An optimum data center efficiency is determined given the target parameters for the data center and the technology pre-requisite parameters for the data center.

  17. Correlations between Abelian monopoles and center vortices

    Energy Technology Data Exchange (ETDEWEB)

    Hosseini Nejad, Seyed Mohsen, E-mail: smhosseininejad@ut.ac.ir; Deldar, Sedigheh, E-mail: sdeldar@ut.ac.ir

    2017-04-15

    We study the correlations between center vortices and Abelian monopoles for SU(3) gauge group. Combining fractional fluxes of monopoles, center vortex fluxes are constructed in the thick center vortex model. Calculating the potentials induced by fractional fluxes constructing the center vortex flux in a thick center vortex-like model and comparing with the potential induced by center vortices, we observe an attraction between fractional fluxes of monopoles constructing the center vortex flux. We conclude that the center vortex flux is stable, as expected. In addition, we show that adding a contribution of the monopole-antimonopole pairs in the potentials induced by center vortices ruins the Casimir scaling at intermediate regime.

  18. INIS National Center in Syria

    International Nuclear Information System (INIS)

    Al-Hallack, R.

    2006-01-01

    International Nuclear Information System (INIS) is the world's leading information system on the peaceful uses of nuclear science and technology and it is operated by the International Atomic Energy Agency (IAEA) in Vienna, Austria. An overview of INIS products, services, philosophy and operation is given. INIS hold a database containing over 2.5 million references increasing at approximately 85,000 references per year and a collection of full text non-conventional, or grey literature that would be hard to obtain elsewhere. In addition, the PC-based software for inputs preparation (WinFIBRE) is demonstrated. INIS national center in Syria is considered as a regional center for INIS inputs preparation. The center is responsible for selecting the relevant nuclear literature produced and published in Syria and preparing the national inputs and send them to INIS Secretariat to be included in the INIS database. The center also provides INIS services and products to users within Syria. Availability of INIS Database on CD-ROMs, which updated monthly, and the internet version, which updated weekly, and the NCL collections are also presented. Finally, translation activity of the center, such as INIS Booklet entitled Presenting INIS, and the INIS Thesaurus into Arabic were mentioned. This was an in-kind contribution from the Atomic Energy Commission of Syria to support the valuable work of the INIS and Nuclear Knowledge Management (NKM) section and will contribute significantly the dissemination of information among the researchers and scientists in the Arab Countries. (author)

  19. Dynamic centering of liquid shells

    International Nuclear Information System (INIS)

    Tsamopoulos, J.A.; Brown, R.A.

    1987-01-01

    The moderate-amplitude axisymmetric oscillations of an inviscid liquid shell surrounding an incompressible gas bubble are calculated by a multiple-time-scale expansion for initial deformations composed of two-lobed perturbations of the shell and a displacement of the bubble from the center of mass of the liquid. Two types of small-amplitude motion are identified and lead to very different nonlinear dynamic interactions, as described by the results valid up to second order in the amplitude of the initial deformation. In the ''bubble mode,'' the oscillations of the captive bubble and the liquid shell are exactly in phase and the bubble vibrates about its initial eccentric location. The bubble moves toward the center of the drop when the shell is perturbed into a ''sloshing mode'' of oscillation where both interfaces move out of phase. These results explain the centering of liquid shells observed in several experiments

  20. Multifunctional centers in rural areas

    DEFF Research Database (Denmark)

    Svendsen, Gunnar Lind Haase

    2009-01-01

    abandoned. One outcome has been closings of schools in remote rural areas. This evidently contributes to exacerbate depopulation in these areas. To stop this tendency, we need new models for high-quality, cost effective public services in rural areas as those as we find in Denmark. This chapter introduces...... ideological roots in history pointing at 19th c. national civic movements and an early 20th c. transnational Garden City movement within urban planning as crucial. Drawing on contemporary case studies of multifunctional centers in Holland and Denmark, I then suggest that public and private donors should...... invest in multifunctional centers in which the local public school is the dynamo. This in order to increase local levels of social as well as human capital. Ideally, such centers should contain both public services such as school, library and health care, private enterprises as hairdressers and banks...

  1. Center for Beam Physics, 1993

    International Nuclear Information System (INIS)

    1994-05-01

    The Center for Beam Physics is a multi-disciplinary research and development unit in the Accelerator and Fusion Research Division at Lawrence Berkeley Laboratory. At the heart of the Center's mission is the fundamental quest for mechanisms of acceleration, radiation and focusing of energy. Dedicated to exploring the frontiers of the physics of (and with) particle and photon beams, its primary mission is to promote the science and technology of the production, manipulation, storage and control systems of charged particles and photons. The Center serves this mission via conceptual studies, theoretical and experimental research, design and development, institutional project involvement, external collaborations, association with industry and technology transfer. This roster provides a glimpse at the scientists, engineers, technical support, students, and administrative staff that make up this team and a flavor of their multifaceted activities during 1993

  2. A multipurpose radiation service center

    International Nuclear Information System (INIS)

    Hofmann, E.-G.

    1977-01-01

    In Germany, AEG-Telefunken has been working as a supplier of irradiation equipment for more than ten years. There is a close cooperation with Radiation Dynamics Inc., Westbury, N.Y. Radiation sources are available for most industrial applications. As a special service AEG is establishing a multipurpose radiation service center in Hamburg-Wedel, Germany. This center will be used by a host of companies to investigate the effects of radiation on a broad range of materials, to develop special processing equipment, to process customer supplied products and to perform R and D work and contracts. Initially this service center will be equipped with one research type High-Power X-ray Unit (200 kV/32 mA) and one industrial type Dynamitron accelerator (1500 kV/37.5 kW). (author)

  3. Centers and homotopy centers in enriched monoidal categories

    Czech Academy of Sciences Publication Activity Database

    Batanin, M.; Markl, Martin

    2012-01-01

    Roč. 230, 4-6 (2012), s. 1811-1858 ISSN 0001-8708 R&D Projects: GA ČR GA201/08/0397 Institutional support: RVO:67985840 Keywords : monoidal categories * center * Hochschild complex Subject RIV: BA - General Mathematics Impact factor: 1.373, year: 2012 http://www.sciencedirect.com/science/article/pii/S0001870812001508

  4. Self-Access Centers: Maximizing Learners’ Access to Center Resources

    Directory of Open Access Journals (Sweden)

    Mark W. Tanner

    2010-09-01

    Full Text Available Originally published in TESL-EJ March 2009, Volume 12, Number 4 (http://tesl-ej.org/ej48/a2.html. Reprinted with permission from the authors.Although some students have discovered how to use self-access centers effectively, the majority appear to be unaware of available resources. A website and database of materials were created to help students locate materials and use the Self-Access Study Center (SASC at Brigham Young University’s English Language Center (ELC more effectively. Students took two surveys regarding their use of the SASC. The first survey was given before the website and database were made available. A second survey was administered 12 weeks after students had been introduced to the resource. An analysis of the data shows that students tend to use SASC resources more autonomously as a result of having a web-based database. The survey results suggest that SAC managers can encourage more autonomous use of center materials by provided a website and database to help students find appropriate materials to use to learn English.

  5. PACS strategy for imaging centers.

    Science.gov (United States)

    Bedel, Victoria; Zdanowicz, Mark

    2004-01-01

    Picture archiving and communications systems (PACS) have been available in imaging centers for many years, but they often were less functional, were not well integrated into patient information systems, and lacked the network backbone to implement a system. As modalities are replaced and technology improves, the ability and time for an imaging center to acquire, integrate, and utilize PACS has arrived. However, each imaging center must determine why it should invest in PACS. A business plan is the fundamental need. Each imaging center must understand its target market, growth rate, and staffing plans. Additional considerations lie in current and future modality availability, the need for offsite delivery of images and reports, and the potential need for remote transmission of images. These issues must be identified and prioritized. A multidisciplinary team is essential. The most successful PACS implementation begins with complete involvement from all levels. The team should be comprised of people with complementary skills who are committed to a common purpose, set of performance goals, and approach for which they hold themselves mutually accountable. The team must jointly decide on the project's objectives. These objectives fall under 4 categories: clinical, service, financial, and performance. PACS must be considered a tool to help accomplish each objective. The imaging center must determine its top priorities, then translate them into a technology "wish list." The center can then list those pieces of technology that are most important and prioritize them. There are even more considerations for connecting multiple imaging centers. The team must create a comprehensive request for proposal (RFP) and determine the vendors that will receive the document. Once the RFP responses have been received and the vendor has been selected, an effective training plan must be executed. Training plans should be competency-based, ensuring comfort and competency among all staff. Upon

  6. Integrating heterogeneous healthcare call centers.

    Science.gov (United States)

    Peschel, K M; Reed, W C; Salter, K

    1998-01-01

    In a relatively short period, OHS has absorbed multiple call centers supporting different LOBs from various acquisitions, functioning with diverse standards, processes, and technologies. However, customer and employee satisfaction is predicated on OHS's ability to thoroughly integrate these heterogeneous call centers. The integration was initiated and has successfully progressed through a balanced program of focused leadership and a defined strategy which includes site consolidation, sound performance management philosophies, and enabling technology. Benefits have already been achieved with even more substantive ones to occur as the integration continues to evolve.

  7. Advertising by academic medical centers.

    Science.gov (United States)

    Larson, Robin J; Schwartz, Lisa M; Woloshin, Steven; Welch, H Gilbert

    2005-03-28

    Many academic medical centers have increased their use of advertising to attract patients. While the content of direct-to-consumer pharmaceutical advertisements (ads) has been studied, to our knowledge, advertising by academic medical centers has not. We aimed to characterize advertising by the nation's top academic medical centers. We contacted all 17 medical centers named to the US News & World Report 2002 honor roll of "America's Best Hospitals" for a semistructured interview regarding their advertising practices. In addition, we obtained and systematically analyzed all non-research-related print ads placed by these institutions in their 5 most widely circulating local newspapers during 2002. Of the 17 institutions, 16 reported advertising to attract patients; 1 stated, "We're just word of mouth." While all 17 centers confirmed the presence of an institutional review board process for approving advertising to attract research subjects, none reported a comparable process for advertising to attract patients. We identified 127 unique non-research-related print ads for the 17 institutions during 2002 (mean, 7.5; range, 0-39). Three ads promoted community events with institution sponsorship, 2 announced genuine public services, and 122 were aimed at attracting patients. Of the latter group, 36 ads (29.5%) promoted the medical center as a whole, while 65 (53.3%) promoted specific clinical departments and 21 (17.2%) promoted single therapeutic interventions or diagnostic tests. The most commonly used marketing strategies included appealing to emotions (61.5%), highlighting institution prestige (60.7%), mentioning a symptom or disease (53.3%), and promoting introductory lectures or special offers likely to lead to further business (47.5%). Of the 21 ads for single interventions, most were for unproved (38.1%) or cosmetic (28.6%) procedures. While more than half of these ads presented benefits, none quantified their positive claims and just 1 mentioned potential harms

  8. Consistent guiding center drift theories

    International Nuclear Information System (INIS)

    Wimmel, H.K.

    1982-04-01

    Various guiding-center drift theories are presented that are optimized in respect of consistency. They satisfy exact energy conservation theorems (in time-independent fields), Liouville's theorems, and appropriate power balance equations. A theoretical framework is given that allows direct and exact derivation of associated drift-kinetic equations from the respective guiding-center drift-orbit theories. These drift-kinetic equations are listed. Northrop's non-optimized theory is discussed for reference, and internal consistency relations of G.C. drift theories are presented. (orig.)

  9. The Aube Center evaluation 2002

    International Nuclear Information System (INIS)

    2003-01-01

    During the meeting of the information local commission, organized the 7 may 2003, the ANDRA took stock on the Aube Center activities during the year 2002. These activities presented in the document concern: the stability of the wastes packages, the personnel safety, the environmental survey, the authorizations of releases, the public information, some data on the exploitation the environment and the radiation protection and a presentation of the storage Center of Morvilliers devoted to the storage of low activity wastes. (A.L.B.)

  10. Telework centers as local development

    OpenAIRE

    Lorentzen, Anne

    2013-01-01

    This paper discusses the establishment of distant work centers as an element in local development strategies in rural areas with a particular view on two new telework centers in Region North DenmarkDistant work is a phenomenon on the rise, due to the development of the internet on the one hand and new flexible work functions on the other hand. Not only the exchange of documents, but also meetings can be organized virtually by still better video conference equipment and programs. An implicatio...

  11. User-centered agile method

    CERN Document Server

    Deuff, Dominique

    2013-01-01

    Agile development methods began to emerge around 20 years ago. However, it was not until the early 2000s that they began to be widely used in industry. This growth was often due to the advent of Internet services requiring faster cycles of development in order to heighten the rate at which an ever-greater number of functionalities were made available. In parallel, user-centered design (UCD) methods were also becoming more and more widely used: hence, user-centered design and agile methods were bound to cross paths, at least in the telecoms industry! During this period, in the field of telec

  12. Agriculture: About EPA's National Agriculture Center

    Science.gov (United States)

    EPA's National Agriculture Center (Ag Center), with the support of the United States Department of Agriculture, serves growers, livestock producers, other agribusinesses, and agricultural information/education providers.

  13. VT Designated New Town Center Boundary

    Data.gov (United States)

    Vermont Center for Geographic Information — Municipalities that lack a historic downtown may obtain New Town Center designation, meeting requirements for planning, capital expenditures, and regulatory tools...

  14. VMware vCenter cookbook

    CERN Document Server

    Kuminsky, Konstantin

    2015-01-01

    If you are a system administrator who has some experience with virtualization and already uses VMware vCenter, but wishes to learn more, then this is the book for you. If you are looking for tips or shortcuts for common administration tasks as well as workarounds for pain points in vSphere administration, you'll find this guide useful.

  15. RIAR training center, Dimitrovgrad, Russia

    International Nuclear Information System (INIS)

    Makin, R.

    1998-01-01

    The presentation describes activities and history of the training Center for NPP personnel at the Research Institute of Atomic Reactors (RIAR) in Dimitrovgrad, Russian Federation since its beginnings in 1993. The courses held for training instructors and specialists as well as Russian NPPs were organised in cooperation with American and German organisations

  16. Introduction | Center for Cancer Research

    Science.gov (United States)

    Introduction In order to meet increasing demands from both NIH intramural and extramural communities for access to a small angle X-ray scattering (SAXS) resource, the Center for Cancer Research (CCR) under the leadership of Jeffrey Strathern and Bob Wiltrout established a partnership user program (PUP) with the Argonne National Laboratory Photon Source in October 2008.

  17. Child-Centered Play Therapy

    Science.gov (United States)

    VanFleet, Rise; Sywulak, Andrea E.; Sniscak, Cynthia Caparosa

    2010-01-01

    Highly practical, instructive, and authoritative, this book vividly describes how to conduct child-centered play therapy. The authors are master clinicians who explain core therapeutic principles and techniques, using rich case material to illustrate treatment of a wide range of difficulties. The focus is on nondirective interventions that allow…

  18. Education Information Centers: An Evaluation.

    Science.gov (United States)

    Tice, Karin E.; Gill, Stephen Joel

    1991-01-01

    Key findings of an evaluation of the Education Information Centers (EICs) project were that (1) many EICs have affected patrons lives; (2) libraries have improved career collections, attracted new patrons, and become viewed as community resources; (3) library staff have developed better ways to ascertain information needs; and (4) new agency…

  19. Center for Ukrainian Cultural Studies

    NARCIS (Netherlands)

    van der Laarse, R.

    2017-01-01

    The Amsterdam-based Center for Ukrainian Cultural Studies (UCS) unites Dutch scholars in Ukrainian art, cinema, media, memory, language, and literature. Launched by the Amsterdam School for Heritage, Memory and Material Culture (AHM) and the University of Amsterdam’s Department of Slavic Languages

  20. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Inside VA Secretary of VA Executive Biographies Organizations History Budget and Performance VA Plans, Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business Congressional Affairs Jobs Benefits Booklet Data & Statistics VA ...

  1. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business ... Get Help for PTSD Help with VA PTSD Care or Benefits Other Common Problems Family and Friends PTSD and Communities Paginas en Espanol Apps, Videos and More Mobile ...

  2. Budgeting for School Media Centers.

    Science.gov (United States)

    Drott, M. Carl

    1978-01-01

    Describes various forms of budgets and discusses concepts in budgeting useful to supervisors of school media centers: line item budgets, capital budgets, creating budgets, the budget calendar, innovations, PPBS (Planning, Programing, Budgeting System), zero-based budgeting, cost-benefit analysis, benefits, benefit guidelines, and budgeting for the…

  3. Climate Prediction Center - monthly Outlook

    Science.gov (United States)

    Weather Service NWS logo - Click to go to the NWS home page Climate Prediction Center Site Map News Outlooks monthly Climate Outlooks Banner OFFICIAL Forecasts June 2018 [UPDATED MONTHLY FORECASTS SERVICE ) Canonical Correlation Analysis ECCA - Ensemble Canonical Correlation Analysis Optimal Climate Normals

  4. Climate Prediction Center - Site Index

    Science.gov (United States)

    Weather Service NWS logo - Click to go to the NWS home page Climate Prediction Center Home Site Map News Means Bulletins Annual Winter Stratospheric Ozone Climate Diagnostics Bulletin (Most Recent) Climate (Hazards Outlook) Climate Assessment: Dec. 1999-Feb. 2000 (Seasonal) Climate Assessment: Mar-May 2000

  5. Center for Adaptive Optics | Software

    Science.gov (United States)

    Optics Software The Center for Adaptive Optics acts as a clearing house for distributing Software to Institutes it gives specialists in Adaptive Optics a place to distribute their software. All software is shared on an "as-is" basis and the users should consult with the software authors with any

  6. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... a-z] More VA More VA Health Health Care Information A-Z Health Topic Finder My Health ... Ask a Question Toll Free Numbers VA » Health Care » PTSD: National Center for PTSD » Public » Videos PTSD: ...

  7. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business Congressional ... Search How to Obtain Articles Alerts User Guide Purpose and Scope Find Assessment ... Reports Research Initiatives Education Initiatives Advisory Boards History and ...

  8. ITMO Photonics: center of excellence

    Science.gov (United States)

    Voznesenskaya, Anna; Bougrov, Vladislav; Kozlov, Sergey; Vasilev, Vladimir

    2016-09-01

    ITMO University, the leading Russian center in photonics research and education, has the mission to train highlyqualified competitive professionals able to act in conditions of fast-changing world. This paradigm is implemented through creation of a strategic academic unit ITMO Photonics, the center of excellence concentrating organizational, scientific, educational, financial, laboratory and human resources. This Center has the following features: dissemination of breakthrough scientific results in photonics such as advanced photonic materials, ultrafast optical and quantum information, laser physics, engineering and technologies, into undergraduate and graduate educational programs through including special modules into the curricula and considerable student's research and internships; transformation of the educational process in accordance with the best international educational practices, presence in the global education market in the form of joint educational programs with leading universities, i.e. those being included in the network programs of international scientific cooperation, and international accreditation of educational programs; development of mechanisms for the commercialization of innovative products - results of scientific research; securing financial sustainability of research in the field of photonics of informationcommunication systems via funding increase and the diversification of funding sources. Along with focusing on the research promotion, the Center is involved in science popularization through such projects as career guidance for high school students; interaction between student's chapters of international optical societies; invited lectures of World-famous experts in photonics; short educational programs in optics, photonics and light engineering for international students; contests, Olympics and grants for talented young researchers; social events; interactive demonstrations.

  9. Colorado Learning Disabilities Research Center.

    Science.gov (United States)

    DeFries, J. C.; And Others

    1997-01-01

    Results obtained from the center's six research projects are reviewed, including research on psychometric assessment of twins with reading disabilities, reading and language processes, attention deficit-hyperactivity disorder and executive functions, linkage analysis and physical mapping, computer-based remediation of reading disabilities, and…

  10. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Budget, & Performance VA Center for Innovation (VACI) Agency Financial Report (AFR) Budget Submission Recovery Act Resources Business ... Dissemination & Training Evaluation Pacific Islands Women’s Health Sciences Positions Available Press & Promotion Contacts for the Media AboutFace ...

  11. Importance of Grid Center Arrangement

    Science.gov (United States)

    Pasaogullari, O.; Usul, N.

    2012-12-01

    In Digital Elevation Modeling, grid size is accepted to be the most important parameter. Despite the point density and/or scale of the source data, it is freely decided by the user. Most of the time, arrangement of the grid centers are ignored, even most GIS packages omit the choice of grid center coordinate selection. In our study; importance of the arrangement of grid centers is investigated. Using the analogy between "Raster Grid DEM" and "Bitmap Image", importance of placement of grid centers in DEMs are measured. The study has been conducted on four different grid DEMs obtained from a half ellipsoid. These grid DEMs are obtained in such a way that they are half grid size apart from each other. Resulting grid DEMs are investigated through similarity measures. Image processing scientists use different measures to investigate the dis/similarity between the images and the amount of different information they carry. Grid DEMs are projected to a finer grid in order to co-center. Similarity measures are then applied to each grid DEM pairs. These similarity measures are adapted to DEM with band reduction and real number operation. One of the measures gives function graph and the others give measure matrices. Application of similarity measures to six grid DEM pairs shows interesting results. These four different grid DEMs are created with the same method for the same area, surprisingly; thirteen out of 14 measures state that, the half grid size apart grid DEMs are different from each other. The results indicated that although grid DEMs carry mutual information, they have also additional individual information. In other words, half grid size apart constructed grid DEMs have non-redundant information.; Joint Probability Distributions Function Graphs

  12. Center for Advanced Computational Technology

    Science.gov (United States)

    Noor, Ahmed K.

    2000-01-01

    The Center for Advanced Computational Technology (ACT) was established to serve as a focal point for diverse research activities pertaining to application of advanced computational technology to future aerospace systems. These activities include the use of numerical simulations, artificial intelligence methods, multimedia and synthetic environments, and computational intelligence, in the modeling, analysis, sensitivity studies, optimization, design and operation of future aerospace systems. The Center is located at NASA Langley and is an integral part of the School of Engineering and Applied Science of the University of Virginia. The Center has four specific objectives: 1) conduct innovative research on applications of advanced computational technology to aerospace systems; 2) act as pathfinder by demonstrating to the research community what can be done (high-potential, high-risk research); 3) help in identifying future directions of research in support of the aeronautical and space missions of the twenty-first century; and 4) help in the rapid transfer of research results to industry and in broadening awareness among researchers and engineers of the state-of-the-art in applications of advanced computational technology to the analysis, design prototyping and operations of aerospace and other high-performance engineering systems. In addition to research, Center activities include helping in the planning and coordination of the activities of a multi-center team of NASA and JPL researchers who are developing an intelligent synthesis environment for future aerospace systems; organizing workshops and national symposia; as well as writing state-of-the-art monographs and NASA special publications on timely topics.

  13. Commission for the Accreditation of Birth Centers

    Science.gov (United States)

    ... Learning Login: Commissioners Birth Centers CABC Learning Place Home Accredited Birth Centers Find CABC Accredited Birth Centers What does ... In the Pursuit of Excellence You are here: Home In the ... for the Accreditation of Birth Centers (CABC) provides support, education, and accreditation to ...

  14. Alternative Fuels Data Center: Natural Gas

    Science.gov (United States)

    Natural Gas Printable Version Share this resource Send a link to Alternative Fuels Data Center : Natural Gas to someone by E-mail Share Alternative Fuels Data Center: Natural Gas on Facebook Tweet about Alternative Fuels Data Center: Natural Gas on Twitter Bookmark Alternative Fuels Data Center: Natural Gas on

  15. Alternative Fuels Data Center: Natural Gas Benefits

    Science.gov (United States)

    Benefits to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Benefits on Facebook Tweet about Alternative Fuels Data Center: Natural Gas Benefits on Twitter Bookmark Alternative Fuels Data Center: Natural Gas Benefits on Google Bookmark Alternative Fuels Data Center: Natural Gas

  16. INFINITY at NASA Stennis Space Center

    Science.gov (United States)

    2010-01-01

    Flags are planted on the roof of the new INFINITY at NASA Stennis Space Center facility under construction just west of the Mississippi Welcome Center at exit 2 on Interstate 10. Stennis and community leaders celebrated the 'topping out' of the new science center Nov. 17, marking a construction milestone for the center. The 72,000-square-foot science and education center will feature space and Earth galleries to showcase the science that underpins the missions of the agencies at Stennis Space Center. The center is targeted to open in 2012.

  17. REGIONAL LOGISTICS CENTER: FORMATION AND FUNCTIONING SPESIFIC

    Directory of Open Access Journals (Sweden)

    Oleg Tkach

    2017-08-01

    Full Text Available In this article the essence of the definition of logistics centers is defined, the main provisions concerning the formation of the logistics center are defined. The formation of a logistic hub is analyzed. The structure of the transport-logistic center is proposed. The basic requirements for the location of the regional logistics center and the principles of its operation are determined. The financial and financial mechanism of a typical logistics center and their effective functioning are presented. It is proved that the most important component of the logistics center is transport. Key words: logistics centers, logistics, hub, distribution centers, transport and logistics centers, regional logistic centers, logistics complex, transport, transport-logistic system.

  18. Patient-centered blood management.

    Science.gov (United States)

    Hohmuth, Benjamin; Ozawa, Sherri; Ashton, Maria; Melseth, Richard L

    2014-01-01

    Transfusions are common in hospitalized patients but carry significant risk, with associated morbidity and mortality that increases with each unit of blood received. Clinical trials consistently support a conservative over a liberal approach to transfusion. Yet there remains wide variation in practice, and more than half of red cell transfusions may be inappropriate. Adopting a more comprehensive approach to the bleeding, coagulopathic, or anemic patient has the potential to improve patient care. We present a patient-centered blood management (PBM) paradigm. The 4 guiding principles of effective PBM that we present include anemia management, coagulation optimization, blood conservation, and patient-centered decision making. PBM has the potential to decrease transfusion rates, decrease practice variation, and improve patient outcomes. PBM's value proposition is highly aligned with that of hospital medicine. Hospitalists' dual role as front-line care providers and quality improvement leaders make them the ideal candidates to develop, implement, and practice PBM. © 2013 Society of Hospital Medicine.

  19. Rolex learning center English guide

    CERN Document Server

    Della Casa, Francesco

    2012-01-01

    The novel architectural form of this building, conceived of by the architects of SAANA (winners of the Pritzker Prize in 2010), compelled the building engineers to come up with unprecedented structural, technical and logistical solutions. And yet, once the Rolex Learning Center was complete, the ingenuity required for its construction had become practically invisible in the eyes of the uninitiated. This richly illustrated guide provides, in condensed form, an account of the extraordinary adventure of the realization of the Rolex Learning Center. It explains in detail the context of its construction and brings to light the spatial subtleties of its architecture. In addition, it provides the visitor of the building with all the needed technical information and many novel facts and figures.

  20. Engineering test facility design center

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    The vehicle by which the fusion program would move into the engineering testing phase of fusion power development is designated the Engineering Test Facility (ETF). The ETF would provide a test bed for reactor components in the fusion environment. In order to initiate preliminary planning for the ETF decision, the Office of Fusion Energy established the ETF Design Center activity to prepare the design of the ETF. This section describes the status of this design

  1. Dynamical processes in galaxy centers

    International Nuclear Information System (INIS)

    Combes, Francoise

    2012-01-01

    How does the gas get in nuclear regions to fuel black holes? How efficient is the feedback? The different processes to cause rapid gas inflow (or outflow) in galaxy centers are reviewed. Non axisymmetries can be created or maintained by internal disk instabilities, or galaxy interactions. Simulations and observations tell us that the fueling is a chaotic and intermittent process, with different scenarios and time-scales, according to the various radial scales across a galaxy.

  2. Technical center for transportation analyses

    International Nuclear Information System (INIS)

    Foley, J.T.

    1978-01-01

    A description is presented of an information search/retrieval/research activity of Sandia Laboratories which provides technical environmental information which may be used in transportation risk analyses, environmental impact statements, development of design and test criteria for packaging of energy materials, and transportation mode research studies. General activities described are: (1) history of center development; (2) environmental information storage/retrieval system; (3) information searches; (4) data needs identification; and (5) field data acquisition system and applications

  3. Clean Energy Solutions Center (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Reategui, S.

    2012-07-01

    The Clean Energy Ministerial launched the Clean Energy Solutions Center in April, 2011 for major economy countries, led by Australia and U.S. with other CEM partners. Partnership with UN-Energy is extending scope to support all developing countries: 1. Enhance resources on policies relating to energy access, small to medium enterprises (SMEs), and financing programs; 2. Offer expert policy assistance to all countries; 3. Expand peer to peer learning, training, and deployment and policy data for developing countries.

  4. NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The National Cancer Institute’s Technology Transfer Center (TTC) facilitates partnerships between the NIH research laboratories and external partners. With specialized teams, TTC guides the interactions of our partners from the point of discovery to patenting, from invention development to licensing. We play a key role in helping to accelerate development of cutting-edge research by connecting our partners to NIH’s world-class researchers, facilities, and knowledge.

  5. F centers emission in KCN

    International Nuclear Information System (INIS)

    Ohkura, H.; Carmo, L.C.S. do; Kalinowski, H.J.; Ribeiro, S.C.

    1976-01-01

    The emission spectrum of F centers in KCN is reported. The temperature dependence of this emission between 62 K and 178K was measured and the energy gap between the relaxed excited state and conduction band could be determined as 070 eV. Below the antiferroelectric transition temperature at 83K a blue shift in the peak of the emission spectrum is observed due partially to the internal Stark effect

  6. Army Continuing Education System Centers

    Science.gov (United States)

    1979-05-01

    Scheme C . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... 6-20 Example Plan–Scheme Coeducation Center for 21,000 Military...Information to supplement construction completion records shall be prepared to instruct the installation on how to gain the most benefit from such...High School Completion Program (HSCP). This gives soldiers a chance to earn a high school diploma or a State-issued high school equivalency certificate

  7. On the center of distances

    Czech Academy of Sciences Publication Activity Database

    Bielas, Wojciech; Plewik, S.; Walczyńska, Marta

    2018-01-01

    Roč. 4, č. 2 (2018), s. 687-698 ISSN 2199-675X R&D Projects: GA ČR GF16-34860L Institutional support: RVO:67985840 Keywords : Cantorval center of distances von Neumann's theorem * set of subsums Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics https://link.springer.com/article/10.1007%2Fs40879-017-0199-4

  8. Learning System Center App Controller

    CERN Document Server

    Naeem, Nasir

    2015-01-01

    This book is intended for IT professionals working with Hyper-V, Azure cloud, VMM, and private cloud technologies who are looking for a quick way to get up and running with System Center 2012 R2 App Controller. To get the most out of this book, you should be familiar with Microsoft Hyper-V technology. Knowledge of Virtual Machine Manager is helpful but not mandatory.

  9. Centralized consolidation/recycling center

    International Nuclear Information System (INIS)

    St. Georges, L.T.; Poor, A.D.

    1995-05-01

    There are approximately 175 separate locations on the Hanford Site where dangerous waste is accumulated in hundreds of containers according to compatibility. Materials that are designated as waste could be kept from entering the waste stream by establishing collection points for these materials and wastes and then transporting them to a centralized consolidation/recycling center (hereinafter referred to as the consolidation center). Once there the materials would be prepared for offsite recycling. This document discusses the removal of batteries, partially full aerosol cans, and DOP light ballasts from the traditional waste management approach, which eliminates 89 satellite accumulation areas from the Hanford Site (43 for batteries, 33 for aerosols, and 13 for DOP ballasts). Eliminating these 89 satellite accumulation areas would reduce by hundreds the total number of containers shipped offsite as hazardous waste (due to the increase in containers when the wastes that are accumulated are segregated according to compatibility for final shipment). This new approach is in line with the U.S. Environmental Protection Agency's (EPA) draft Universal Waste Rules for these open-quotes nuisanceclose quotes and common waste streams. Additionally, future reviews of other types of wastes that can be handled in this less restrictive and more cost-effective manner will occur as part of daily operations at the consolidation center. The Hanford Site has been identified as a laboratory for reinventing government by the Secretary of the U.S. Department of Energy (DOE), Hazel O'Leary, and as a demonstration zone where open-quotes innovative ideas, processes and technologies can be created, tested and demonstrated.close quotes Additionally, DOE, EPA, and the Washington State Department of Ecology (Ecology) have agreed to cut Hanford cleanup costs by $1 billion over a 5-year period

  10. Process Engineering Technology Center Initiative

    Science.gov (United States)

    Centeno, Martha A.

    2002-01-01

    NASA's Kennedy Space Center (KSC) is developing as a world-class Spaceport Technology Center (STC). From a process engineering (PE) perspective, the facilities used for flight hardware processing at KSC are NASA's premier factories. The products of these factories are safe, successful shuttle and expendable vehicle launches carrying state-of-the-art payloads. PE is devoted to process design, process management, and process improvement, rather than product design. PE also emphasizes the relationships of workers with systems and processes. Thus, it is difficult to speak of having a laboratory for PE at K.S.C. because the entire facility is practically a laboratory when observed from a macro level perspective. However, it becomes necessary, at times, to show and display how K.S.C. has benefited from PE and how K.S.C. has contributed to the development of PE; hence, it has been proposed that a Process Engineering Technology Center (PETC) be developed to offer a place with a centralized focus on PE projects, and a place where K.S.C.'s PE capabilities can be showcased, and a venue where new Process Engineering technologies can be investigated and tested. Graphics for showcasing PE capabilities have been designed, and two initial test beds for PE technology research have been identified. Specifically, one test bed will look into the use of wearable computers with head mounted displays to deliver work instructions; the other test bed will look into developing simulation models that can be assembled into one to create a hierarchical model.

  11. Kennedy Space Center Spaceport Analysis

    Science.gov (United States)

    Wary, Samantha A.

    2013-01-01

    Until the Shuttle Atlantis' final landing on July 21, 2011, Kennedy Space Center (KSC) served as NASA's main spaceport, which is a launch and landing facility for rockets and spacecraft that are attempting to enter orbit. Many of the facilities at KSC were created to assist the Shuttle Program. One of the most important and used facilities is the Shuttle Landing Facility (SLF), This was the main landing area for the return of the shuttle after her mission in space. · However, the SLF has also been used for a number of other projects including straight-line testing by Gibbs Racing, weather data collection by NOAA, and an airfield for the KSC helicopters. This runway is three miles long with control tower at midfield and a fire department located at the end in care of an emergency. This facility, which was part of the great space race, will continue to be used for historical events as Kennedy begins to commercialize its facilities. KSC continues to be an important spaceport to the government, and it will transform into an important spaceport for the commercial industry as well. During my internship at KSC's Center Planning and Development Directorate, I had the opportunity to be a part of the negotiation team working on the agreement for Space Florida to control the Shuttle Landing Facility. This gave me the opportunity to learn about all the changes that are occurring here at Kennedy Space Center. Through various meetings, I discovered the Master Plan and its focus is to transform the existing facilities that were primarily used for the Shuttle Program, to support government operations and commercial flights in the future. This. idea is also in a new strategic business plan and completion of a space industry market analysis. All of these different documentations were brought to my attention and I. saw how they came together in the discussions of transitioning the SLF to a commercial operator, Space Florida. After attending meetings and partaking in discussions for

  12. Materials Characterization Center program plan

    International Nuclear Information System (INIS)

    Nelson, R.D.; Ross, W.A.; Hill, O.F.; Mendel, J.E.; Merz, M.D.; Turcotte, R.P.

    1980-03-01

    The Materials Characterization Center (MCC) has been established at Pacific Northwest Laboratory as part of the Materials Characterization Organization for providing an authoritative, referenceable basis for establishing nuclear waste material properties and test methods. The MCC will provide a data base that will include information on the components of the waste emplacement package - the spent fuel or processed waste form and the engineered barriers - and their interaction with each other and as affected by the environment. The MCC will plan materials testing, develop and document procedures, collect and analyze existing materials data, and conduct tests as necessary

  13. Management of nuclear training center

    International Nuclear Information System (INIS)

    Seo, In Suk; Lee, Han Young; Cho, Boung Jae; Lee, Seung Hee; Lee, Eoi Jin; You, Byung Hoon; Lee, Won Ku; Jeon, Hyung Ryeon; Seo, Kyung Won; Kim, Young Joong; Kim, Ik Hyun; Hyun, Ha Il; Choi, Il Ki; Hong, Choon Sun; Won, Jong Yeul; Joo, Yong Chang; Nam, Jae Yeul; Sin, Eun Jeong

    1996-02-01

    This report describes the annual results of training courses. The scope and contents are as follows : 1. Regional and interregional training courses, 2. Training courses assisted by foreign experts, 3. Training courses for nuclear industry personnel, 4. Training courses for internal staff-members, 5. Training courses under the law. The nuclear training center executed the open-door training courses for 2,699 engineers/scientists from the regulatory body, nuclear industries, research institutes and other related organizations by means of offering 69 training courses during the fiscal year 1995. (Author) .new

  14. NASA Airline Operations Research Center

    Science.gov (United States)

    Mogford, Richard H.

    2016-01-01

    This is a PowerPoint presentation NASA airline operations center (AOC) research. It includes information on using IBM Watson in the AOC. It also reviews a dispatcher decision support tool call the Flight Awareness Collaboration Tool (FACT). FACT gathers information about winter weather onto one screen and includes predictive abilities. It should prove to be useful for airline dispatchers and airport personnel when they manage winter storms and their effect on air traffic. This material is very similar to other previously approved presentations with the same title.

  15. Air Risk Information Support Center

    Energy Technology Data Exchange (ETDEWEB)

    Shoaf, C.R.; Guth, D.J. [Environmental Protection Agency, Washington, DC (United States)

    1990-12-31

    The Air Risk Information Support Center (Air RISC) was initiated in early 1988 by the US Environmental Protection Agency`s (EPA) Office of Health and Environmental Assessment (OHEA) and the Office of Air Quality Planning and Standards (OAQPS) as a technology transfer effort that would focus on providing information to state and local environmental agencies and to EPA Regional Offices in the areas of health, risk, and exposure assessment for toxic air pollutants. Technical information is fostered and disseminated by Air RISCs three primary activities: (1) a {open_quotes}hotline{close_quotes}, (2) quick turn-around technical assistance projects, and (3) general technical guidance projects. 1 ref., 2 figs.

  16. Information on the Karlsruhe Nuclear Research Center

    International Nuclear Information System (INIS)

    Reuter, H.H.

    1980-01-01

    A short overview is given about the origins of Karlsruhe Nuclear Research Center. The historical development of the different companies operating the Center is shown. Because the original task assigned to the Center was the construction and testing of the first German reactor exclusively built by German companies, a detailed description of this reactor and the changes made afterwards is presented. Next, today's organizational structure of the Center is outlined and the development of the Center's financing since its foundation is shown. A short overview about the structure of employees from the Center's beginning up to now is also included as well as a short description of today's main activities. (orig.)

  17. Midwest Clean Energy Application Center

    Energy Technology Data Exchange (ETDEWEB)

    Cuttica, John; Haefke, Cliff

    2013-12-31

    The Midwest Clean Energy Application Center (CEAC) was one of eight regional centers that promoted and assisted in transforming the market for combined heat and power (CHP), waste heat to power (WHP), and district energy (DE) technologies and concepts throughout the United States between October 1, 2009 and December 31, 2013. The key services the CEACs provided included: Market Opportunity Analyses – Supporting analyses of CHP market opportunities in diverse markets including industrial, federal, institutional, and commercial sectors. Education and Outreach – Providing information on the energy and non-energy benefits and applications of CHP to state and local policy makers, regulators, energy end-users, trade associations and others. Information was shared on the Midwest CEAC website: www.midwestcleanergy.org. Technical Assistance – Providing technical assistance to end-users and stakeholders to help them consider CHP, waste heat to power, and/or district energy with CHP in their facility and to help them through the project development process from initial CHP screening to installation. The Midwest CEAC provided services to the Midwest Region that included the states of Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, and Wisconsin.

  18. [Communication center in public health].

    Science.gov (United States)

    George, W; Grimminger, F; Krause, B

    2002-06-01

    The Communications Center's portfolio covers areas such as marketing, contacts, distribution of information, sales activities and collection of bills by telephone (encashment). A special emphasis is Customer Care Management (Customer Relationship Management) to the patient and his caregivers (relatives), the customers, especially the physicians who send their patients to the hospital and the hospital doctor. By providing communication centers, the hospital would be able to improve the communication with the G.P.s, and identify the wishes and requirements more accurately and easily from the beginning. Dealing effectively with information and communication is already also of special importance for hospital doctors today. One can assume that the demands on doctors in this respect will become even more complex in the future. Doctors who are involved in scientific research are of course fully aware of the growing importance of the Internet with its new information and communication channels. Therefore analysing the current situation, the demands on a future information management system can be formulated: A system that will help doctors to avoid dealing with little goal-oriented information and thus setting up effective communication channels; an information system which is multi-media oriented towards the interests and needs of the patients and patient's relatives and which is further developed continually and directly by those involved.

  19. Reinventing the academic health center.

    Science.gov (United States)

    Kirch, Darrell G; Grigsby, R Kevin; Zolko, Wayne W; Moskowitz, Jay; Hefner, David S; Souba, Wiley W; Carubia, Josephine M; Baron, Steven D

    2005-11-01

    Academic health centers have faced well-documented internal and external challenges over the last decade, putting pressure on organizational leaders to develop new strategies to improve performance while simultaneously addressing employee morale, patient satisfaction, educational outcomes, and research growth. In the aftermath of a failed merger, new leaders of The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center encountered a climate of readiness for a transformational change. In a case study of this process, nine critical success factors are described that contributed to significant performance improvement: performing a campus-wide cultural assessment and acting decisively on the results; making values explicit and active in everyday decisions; aligning corporate structure and governance to unify the academic enterprise and health system; aligning the next tier of administrative structure and function; fostering collaboration and accountability-the creation of unified campus teams; articulating a succinct, highly focused, and compelling vision and strategic plan; using the tools of mission-based management to realign resources; focusing leadership recruitment on organizational fit; and "growing your own" through broad-based leadership development. Outcomes assessment data for academic, research, and clinical performance showed significant gains between 2000 and 2004. Organizational transformation as a result of the nine factors is possible in other institutional settings and can facilitate a focus on crucial quality initiatives.

  20. NASA's engineering research centers and interdisciplinary education

    Science.gov (United States)

    Johnston, Gordon I.

    1990-01-01

    A new program of interactive education between NASA and the academic community aims to improve research and education, provide long-term, stable funding, and support cross-disciplinary and multi-disciplinary research. The mission of NASA's Office of Aeronautics, Exploration and Technology (OAET) is discussed and it is pointed out that the OAET conducts about 10 percent of its total R&D program at U.S. universities. Other NASA university-based programs are listed including the Office of Commercial Programs Centers for the Commercial Development of Space (CCDS) and the National Space Grant program. The importance of university space engineering centers and the selection of the nine current centers are discussed. A detailed composite description is provided of the University Space Engineering Research Centers. Other specialized centers are described such as the Center for Space Construction, the Mars Mission Research Center, and the Center for Intelligent Robotic Systems for Space Exploration. Approaches to educational outreach are discussed.

  1. Center for Food Safety and Applied Nutrition

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Food Safety and Applied Nutrition, known as CFSAN, is one of six product-oriented centers, in addition to a nationwide field force, that carry out the...

  2. Birthing Centers and Hospital Maternity Services

    Science.gov (United States)

    ... Educators Search English Español Birthing Centers and Hospital Maternity Services KidsHealth / For Parents / Birthing Centers and Hospital Maternity Services What's in this article? Giving Birth at ...

  3. New Mexico Museums and Cultural Centers

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset provides an initial version of the locations of museums and cultural centers in New Mexico, in point form, with limited attributes, compiled using...

  4. Industrial Assessment Center (IAC) Operations Manual

    Energy Technology Data Exchange (ETDEWEB)

    Gopalakrishnan, Bhaskaran [West Virginia Univ., Morgantown, WV (United States); Nimbalkar, Sachin U. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wenning, Thomas J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Thirumaran, Kiran [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-04-01

    IAC Operations Manual describes organizational model and operations of the Industrial Assessment Center (IAC), Center management activities, typical process of energy assessment, and energy assessment data for specific industry sectors.

  5. EPA Center for Corporate Climate Leadership

    Science.gov (United States)

    EPA's Center for Corporate Climate Leadership is a comprehensive resource to help organizations measure & manage GHG emissions. The Center provides technical tools, educational resources, opportunities for information sharing & highlights best practices.

  6. Center Innovation Fund: AFRC CIF Program

    Data.gov (United States)

    National Aeronautics and Space Administration — The Armstrong Flight Research Center is NASA’s primary center for atmospheric flight research and operations, with a vision “to fly what others only...

  7. Remote Sensing/Geographic Information Systems Center

    Data.gov (United States)

    Federal Laboratory Consortium — The RS/GIS Center, located at ERDC's Cold Regions Research and Engineering Laboratory, in Hanover, New Hampshire, is the Corps of Engineers Center of Expertise for...

  8. Issues at a university based FEL center

    International Nuclear Information System (INIS)

    Smith, T.I.; Schwettman, H.A.

    1998-01-01

    The Stanford FEL Center was established in September 1990. In this paper, the FEL itself, the Center infrastructure, the interaction with experimenters and the educational mission are described. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  9. 76 FR 17139 - Health Center Program

    Science.gov (United States)

    2011-03-28

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration Health Center Program AGENCY: Health Resources and Services Administration, HHS. ACTION: Notice of Noncompetitive... Improvement Project (CIP) from Saint Vincent's Catholic Medical Centers (SVCMC) of New York, current grantee...

  10. Competitive Intelligence and the Information Center.

    Science.gov (United States)

    Greene, H. Frances

    1988-01-01

    Examines the competitive intelligence approach to corporate information gathering, and discusses how it differs from the traditional library information center approach. Steps for developing a competitive intelligence system in the library information center are suggested. (33 references) (MES)

  11. 2011 Las Conchas Post Fire Center Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This data set consists of photo centers of raw aerial images representing multi-spectral (red, green, blue, near-infrared) digital aerial imagery of the Las Conchas...

  12. Probability distribution of machining center failures

    International Nuclear Information System (INIS)

    Jia Yazhou; Wang Molin; Jia Zhixin

    1995-01-01

    Through field tracing research for 24 Chinese cutter-changeable CNC machine tools (machining centers) over a period of one year, a database of operation and maintenance for machining centers was built, the failure data was fitted to the Weibull distribution and the exponential distribution, the effectiveness was tested, and the failure distribution pattern of machining centers was found. Finally, the reliability characterizations for machining centers are proposed

  13. PSI-Center Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Jarboe, Thomas R. [Univ. of Washington, Seattle, WA (United States); Shumlak, Uri [Univ. of Washington, Seattle, WA (United States); Sovinec, Carl [Univ. of Washington, Seattle, WA (United States); Hansen, Chris [Univ. of Washington, Seattle, WA (United States); Ji, Jeong-Young [Utah State Univ., Logan, UT (United States); Nelson, Brian [Univ. of Wisconsin, Madison, WI (United States)

    2017-04-20

    This is the Final Progress Report of the Plasma Science and Innovation Center (PSI-Center) covering March 2014 through February 2017. The Center has accomplished a great deal during this period. The PSI-Center is organized into four groups: Edge and Dynamic Neutrals; Transport and Kinetic Effects; Equilibrium, Stability, and Kinetic Effects in 3D Topologies; and Interface for Validation. Each group has made good progress and the results from each group are given in detail.

  14. Electrolysis activities at FCH Test Center

    DEFF Research Database (Denmark)

    Ravn Nielsen, Eva; Nygaard, Frederik Berg

    FCH Test Center for fuel cell and hydrogen technologies was established in 2010 at Risø DTU in Denmark. Today, the test center is part of DTU Energy Conversion. The center gives industry access to advanced testing and demonstration of components and systems. A number of national projects and EU...... projects regarding water electrolysis involve FCH Test Center as a partner. This presentation gives an overview of the activities....

  15. PREFACE: Galactic Center Workshop 2006

    Science.gov (United States)

    Schödel, Rainer; Bower, Geoffrey C.; Muno, Michael P.; Nayakshin, Sergei; Ott, Thomas

    2006-12-01

    We are pleased to present the proceedings from the Galactic Center Workshop 2006—From the Center of the Milky Way to Nearby Low-Luminosity Galactic Nuclei. The conference took place in the Physikzentrum, Bad Honnef, Germany, on 18 to 22 April 2006. It is the third workshop of this kind, following the Galactic Center Workshops held 1998 in Tucson, Arizona, and 2002 in Kona, Hawaii. The center of the Milky Way is the only galactic nucleus of a fairly common spiral galaxy that can be observed in great detail. With a distance of roughly 8 kpc, the resolution that can currently be achieved is of the order 40 mpc/8000 AU in the X-ray domain, 2 mpc/400 AU in the near-infrared, and 0.01 mpc/1 AU with VLBI in the millimeter domain. This is two to three orders of magnitude better than for any comparable nearby galaxy, making thus the center of the Milky Way thetemplate object for the general physical interpretation of the phenomena that can be observed in galactic nuclei. We recommend the summary article News from the year 2006 Galactic Centre workshopby Mark Morris and Sergei Nayakshin—who also gave the summary talk of the conference—to the reader in order to obtain a first, concise overview of the results presented at the workshop and some of the currently most exciting—and debated—developments in recent GC research. While the workshops held in 1998 and 2002 were dedicated solely to the center of the Milky Way, the field of view was widened in Bad Honnef to include nearby low-luminosity nuclei. This new feature followed the realization that not only the GC serves as a template for understanding extragalactic nuclei, but that the latter can also provide the context and broader statistical base for understanding the center of our Milky Way. This concerns especially the accretion and emission processes related to the Sagittarius A*, the manifestation of the super massive black hole in the GC, but also the surprising observation of great numbers of massive, young

  16. Alternative Fuels Data Center: Biodiesel Equipment Options

    Science.gov (United States)

    Equipment Options to someone by E-mail Share Alternative Fuels Data Center: Biodiesel Equipment Options on Facebook Tweet about Alternative Fuels Data Center: Biodiesel Equipment Options on Twitter Bookmark Alternative Fuels Data Center: Biodiesel Equipment Options on Google Bookmark Alternative Fuels

  17. Mailman Segal Center for Human Development | NSU

    Science.gov (United States)

    rendition of the National Anthem sung by Jonathan Richard, a young man with an autism spectrum disorder (ASD Dean Jim & Jan Moran Family Center Village Collaborations Early Learning Programs About Early Learning Programs Family Center Preschool About Our Preschool Enrollment Family Center Infant & Toddler

  18. Academic Specialization and Contemporary University Humanities Centers

    Science.gov (United States)

    Brownley, Martine W.

    2012-01-01

    Given the academic specialization endemic today in humanities disciplines, some of the most important work of humanities centers has become promoting education about the humanities in general. After charting the rise of humanities centers in the US, three characteristics of centers that enable their advancement of larger concerns of the humanities…

  19. The Invention and Institutionalization of Volunteer Centers

    DEFF Research Database (Denmark)

    Lorentzen, Håkon; Henriksen, Lars Skov

    2014-01-01

    the Norwegian centers lacked a national coordinating unit. Third, an independent legal form in which local associations are members may have helped Danish centers bring about a sense of local ownership. In Norway, volunteer centers had weak ties to other local voluntary associations and were at times perceived...

  20. National Rehabilitation Hospital Assistive Technology Research Center

    Science.gov (United States)

    1995-10-01

    Shoulder-Arm Orthoses Several years ago, the Rehabilitation Engineering Research Center (RERC) on Rehabilitation Robotics in Delaware1 identified a... exoskeletal applications for persons with disabilities. 2. Create a center of expertise in rehabilitation technology transfer that benefits persons with...AD COOPERATIVE AGREEMENT NUMBER: DAMD17-94-V-4036 TITLE: National Rehabilitation Hospital Assistive Technology- Research Center PRINCIPAL

  1. 77 FR 3242 - Comprehensive Centers Program

    Science.gov (United States)

    2012-01-23

    ... training, technical assistance, and professional development to SEAs, LEAs, regional educational agencies..., instruction, teacher quality, innovation and improvement, or high schools. The 16 Regional Centers focused... requirements for all Regional Centers do not support the development of new content. A Regional Center...

  2. Clean Energy Solutions Center Services (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2014-04-01

    The Clean Energy Solutions Center (Solutions Center) helps governments, advisors and analysts create policies and programs that advance the deployment of clean energy technologies. The Solutions Center partners with international organizations to provide online training, expert assistance, and technical resources on clean energy policy.

  3. Alternative Fuels Data Center: Natural Gas Vehicles

    Science.gov (United States)

    Natural Gas Printable Version Share this resource Send a link to Alternative Fuels Data Center : Natural Gas Vehicles to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Vehicles on Facebook Tweet about Alternative Fuels Data Center: Natural Gas Vehicles on Twitter Bookmark Alternative

  4. Development and Demise of a Women's Center.

    Science.gov (United States)

    Liss, Lora

    The formation, development, and demise of a women's center in suburban New York are described. The women's center resulted from a conference designed to assess problems confronting women and to mobilize resources to meet those problems. However, after the formation of the center, a struggle for leadership and conflicts over the values and beliefs…

  5. Une maison de culture (A Culture Center).

    Science.gov (United States)

    Mourlevat, Alain

    1980-01-01

    Describes the "Culture Center" designed by Le Corbusier and located in Firminy, France. The role of the center in arousing intellectual curiosity in people living in a technological age is discussed. The audience of this culture center, young people, and the types of activities directed toward them are described. (AMH)

  6. The Poison Control Center--Its Role

    Science.gov (United States)

    Manoguerra, Anthony S.

    1976-01-01

    Poison Control Centers are being utilized by more schools of pharmacy each year as training sites for students. This paper discusses what such a center is, its services, changes anticipated in the poison center system in the next several years and how they may influence pharmacy education, specifically as it relates to clinical toxicology.…

  7. Regional Test Center Operations Manual

    Energy Technology Data Exchange (ETDEWEB)

    Stein, Joshua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Burnham, Laurie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Christian Birk [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-07-01

    The U.S. DOE Regional Test Center for Solar Technologies program was established to validate photovoltaic (PV) technologies installed in a range of different climates. The program is funded by the Energy Department's SunShot Initiative. The initiative seeks to make solar energy cost competitive with other forms of electricity by the end of the decade. Sandia National Laboratory currently manages four different sites across the country. The National Renewable Energy Laboratory manages a fifth site in Colorado. The entire PV portfolio currently includes 20 industry partners and almost 500 kW of installed systems. The program follows a defined process that outlines tasks, milestones, agreements, and deliverables. The process is broken out into four main parts: 1) planning and design, 2) installation, 3) operations, and 4) decommissioning. This operations manual defines the various elements of each part.

  8. Southern Energy Efficiency Center (SEEC)

    Energy Technology Data Exchange (ETDEWEB)

    Vieira, Robin; Sonne, Jeffrey; Withers, Charles; Cummings, James; Verdict, Malcolm; Roberts, Sydney

    2009-09-30

    The Southern Energy Efficiency Center (SEEC) builds collaborative partnerships with: state and local governments and their program support offices, the building delivery industry (designers, contractors, realtors and commissioning agents), product manufacturers and their supply chains, utilities and their program implementers, consumers and other stakeholders in order to forge a strong regional network of building energy efficiency allies. Through a project Steering Committee composed of the state energy offices and building industry stakeholders, the SEEC works to establish consensus-based goals, priorities and strategies at the regional, state and local levels that will materially advance the deployment of high-performance “beyond code” buildings. In its first Phase, SEEC will provide limited technical and policy support assistance, training, certification and education to a wide spectrum of the building construction, codes and standards, and the consumer marketplace.

  9. Danish User-Centered Innovation

    DEFF Research Database (Denmark)

    Jeppesen, Lars Bo

    2007-01-01

    Danish User-centered Innovation Lab (DUCI lab) is a collaboration between faculty at Copenhagen Business School, Aarhus School of Business and Massachusetts Institute of Technology, based at Copenhagen Business School. DUCI lab is a unique effort to understand the issues involved in user innovation...... processes, with particular emphasis on managing user driven innovation. The project takes advantage of CBS location in Denmark. Denmark has been at the forefront in creating policies that favor user driven innovation. CBS's location at the heart of one of the world's most vibrant user driven regions...... companies and on how such practices can be diffused broadly for the benefit of start-ups, SME's and other types of organizations....

  10. The Micropaleontological Reference Centers Network

    Directory of Open Access Journals (Sweden)

    David Lazarus

    2006-09-01

    Full Text Available The Micropaleontological Reference Centers (MRCscomprise large microfossil slide collections prepared from core samples obtained through the Deep Sea Drilling Project(DSDP and Ocean Drilling Program (ODP. The MRCs have been maintained for three decades, largely as a volunteer effort by a global network of curators at more than a dozen institutions (Fig.1, Table 1. They were originallyintended to provide a permanent micropaleontological archive for the DSDP; however, as their geographic and stratigraphic coverage has increased they have become increasingly valuable for research and teaching. This article describes the MRCs and their current usage, identifi es the need to maintain and improve the accuracy of the microfossil taxonomy upon which most DSDP and ODP geochronologyis based, and cites the potential for the future use of the MRCs by the Integrated Ocean Drilling Program (IODP.

  11. Hanford Nuclear Energy Center study

    International Nuclear Information System (INIS)

    Harty, H.

    1976-01-01

    Studies of a Nuclear Energy Center (NEC) at Hanford have not revealed any insurmountable technical problems, but problems have been identified that appear to be more difficult to resolve than for dispersed siting. Major technical developments in meteorology, and probably in seismology, are needed before an environmental report or safety analysis report could be prepared for an NEC. It would be helpful in further NEC studies if licensing requirements (and related criteria) were defined for them. An NEC will likely cause a step change in the amount of planning and involvement of regional groups in the energy picture compared to dispersed siting. The tools that must be developed for analysis of NECs will probably be used for evaluating dispersed siting in greater detail. NECs will probably bring about the use of dry or wet/dry cooling before it is required in equivalent amount for dispersed plants

  12. Multiple single-centered attractors

    International Nuclear Information System (INIS)

    Dominic, Pramod; Mandal, Taniya; Tripathy, Prasanta K.

    2014-01-01

    In this paper we study spherically symmetric single-centered attractors in N=2 supergravity in four dimensions. The attractor points are obtained by extremising the effective black hole potential in the moduli space. Both supersymmetric as well as non-supersymmetric attractors exist in mutually exclusive domains of the charge lattice. We construct axion free supersymmetric as well as non-supersymmetric multiple attractors in a simple two parameter model. We further obtain explicit examples of two distinct non-supersymmetric attractors in type IIA string theory compactified on K3×T"2 carrying D0−D4−D6 charges. We compute the entropy of these attractors and analyse their stability in detail.

  13. Optimal oscillation-center transformations

    International Nuclear Information System (INIS)

    Dewar, R.L.

    1984-08-01

    A variational principle is proposed for defining that canonical transformation, continuously connected with the identity transformation, which minimizes the residual, coordinate-dependent part of the new Hamiltonian. The principle is based on minimization of the mean-square generalized force. The transformation reduces to the action-angle transformation in that part of the phase space of an integrable system where the orbit topology is that of the unperturbed system, or on primary KAM surfaces. General arguments in favor of this definition are given, based on Galilean invariance, decay of the Fourier spectrum, and its ability to include external fields or inhomogeneous systems. The optimal oscillation-center transformation for the physical pendulum, or particle in a sinusoidal potential, is constructed

  14. Center for Extended Magnetohydrodynamics Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Jesus [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2017-02-14

    This researcher participated in the DOE-funded Center for Extended Magnetohydrodynamics Modeling (CEMM), a multi-institutional collaboration led by the Princeton Plasma Physics Laboratory with Dr. Stephen Jardin as the overall Principal Investigator. This project developed advanced simulation tools to study the non-linear macroscopic dynamics of magnetically confined plasmas. The collaborative effort focused on the development of two large numerical simulation codes, M3D-C1 and NIMROD, and their application to a wide variety of problems. Dr. Ramos was responsible for theoretical aspects of the project, deriving consistent sets of model equations applicable to weakly collisional plasmas and devising test problems for verification of the numerical codes. This activity was funded for twelve years.

  15. Ohio Advanced Energy Manufacturing Center

    Energy Technology Data Exchange (ETDEWEB)

    Kimberly Gibson; Mark Norfolk

    2012-07-30

    The program goal of the Ohio Advanced Energy Manufacturing Center (OAEMC) is to support advanced energy manufacturing and to create responsive manufacturing clusters that will support the production of advanced energy and energy-efficient products to help ensure the nation's energy and environmental security. This goal cuts across a number of existing industry segments critical to the nation's future. Many of the advanced energy businesses are starting to make the transition from technology development to commercial production. Historically, this transition from laboratory prototypes through initial production for early adopters to full production for mass markets has taken several years. Developing and implementing manufacturing technology to enable production at a price point the market will accept is a key step. Since these start-up operations are configured to advance the technology readiness of the core energy technology, they have neither the expertise nor the resources to address manufacturing readiness issues they encounter as the technology advances toward market entry. Given the economic realities of today's business environment, finding ways to accelerate this transition can make the difference between success and failure for a new product or business. The advanced energy industry touches a wide range of industry segments that are not accustomed to working together in complex supply chains to serve large markets such as automotive and construction. During its first three years, the Center has catalyzed the communication between companies and industry groups that serve the wide range of advanced energy markets. The Center has also found areas of common concern, and worked to help companies address these concerns on a segment or industry basis rather than having each company work to solve common problems individually. EWI worked with three industries through public-private partnerships to sew together disparate segments helping to promote

  16. Telework centers as local development

    DEFF Research Database (Denmark)

    Lorentzen, Anne

    2013-01-01

    of the telework center projects in terms of e.g. jobs, entrepreneurship, attraction or retention of population, and reduced commuting. Also the challenges and risks of failure connected with them will be discussed. Based on this points for further research will be suggested. Theoretically the paper will draw...... and new flexible work functions on the other hand. Not only the exchange of documents, but also meetings can be organized virtually by still better video conference equipment and programs. An implication is that an increasing number of new service jobs in the knowledge economy can be carried out...... regardless of location, as long as there is access to internet. Not only firms, but individual labor is potentially liberated from the logic of physical location and proximity. Technically speaking ‘geography is dead’ and the clustering of new service jobs in big cities is no longer a technical necessity...

  17. Hanford Nuclear Energy Center study

    Energy Technology Data Exchange (ETDEWEB)

    Harty, H.

    1976-03-16

    Studies of a Nuclear Energy Center (NEC) at Hanford have not revealed any insurmountable technical problems, but problems have been identified that appear to be more difficult to resolve than for dispersed siting. Major technical developments in meteorology, and probably in seismology, are needed before an environmental report or safety analysis report could be prepared for an NEC. It would be helpful in further NEC studies if licensing requirements (and related criteria) were defined for them. An NEC will likely cause a step change in the amount of planning and involvement of regional groups in the energy picture compared to dispersed siting. The tools that must be developed for analysis of NECs will probably be used for evaluating dispersed siting in greater detail. NECs will probably bring about the use of dry or wet/dry cooling before it is required in equivalent amount for dispersed plants.

  18. User-centered ecotourism development.

    Science.gov (United States)

    Talsma, L; Molenbroek, J F M

    2012-01-01

    The transfer of knowledge in an ecotourism project is never a one-way affair. An approach connected to bottom-up development is the submersion into another culture, while creating a new organizational structure. For co-creation, patterns that are often latent, such as leadership roles, the association with business, or even the color of education can be revealed by carefully facilitated brainstorms or workshops. Especially in countries with a different hierarchical structure, such as Indonesia compared to Holland, a careful analysis is needed before starting cooperation. Although a case is only a temporary view on a situation and not a guarantee for a truly sustainable system, the bottom-up approach tested has interesting starting points for an ecotourism system. Two cases were conducted in Bali, Indonesia, which resulted in guidelines on how to approach user-centered ecotourism development.

  19. Center for Advanced Separation Technology

    Energy Technology Data Exchange (ETDEWEB)

    Honaker, Rick

    2013-09-30

    The U.S. is the largest producer of mining products in the world. In 2011, U.S. mining operations contributed a total of $232 billion to the nation’s GDP plus $138 billion in labor income. Of this the coal mining industry contributed a total of $97.5 billion to GDP plus $53 billion in labor income. Despite these contributions, the industry has not been well supported with research and development funds as compared to mining industries in other countries. To overcome this problem, the Center for Advanced Separation Technologies (CAST) was established to develop technologies that can be used by the U.S. mining industry to create new products, reduce production costs, and meet environmental regulations. Originally set up by Virginia Tech and West Virginia University, CAST is now a five-university consortium – Virginia Tech, West Virginia University, University of Kentucky, University of Utah and Montana Tech, - that is supported through U.S. DOE Cooperative Agreement No. DE-FE0000699, Center for Advanced Separation Technology. Much of the research to be conducted with Cooperative Agreement funds will be longer term, high-risk, basic research and will be carried out in two broad areas: Advanced Pre-Combustion Clean Coal Technologies and Gas-Gas Separations. Distribution of funds is handled via competitive solicitation of research proposals through Site Coordinators at the five member universities. These were reviewed and the selected proposals were forwarded these to the DOE/NETL Project Officer for final review and approval. The successful projects are listed below by category, along with abstracts from their final reports.

  20. Complex centers of polynomial differential equations

    Directory of Open Access Journals (Sweden)

    Mohamad Ali M. Alwash

    2007-07-01

    Full Text Available We present some results on the existence and nonexistence of centers for polynomial first order ordinary differential equations with complex coefficients. In particular, we show that binomial differential equations without linear terms do not have complex centers. Classes of polynomial differential equations, with more than two terms, are presented that do not have complex centers. We also study the relation between complex centers and the Pugh problem. An algorithm is described to solve the Pugh problem for equations without complex centers. The method of proof involves phase plane analysis of the polar equations and a local study of periodic solutions.