WorldWideScience

Sample records for wannier function analysis

  1. Quantum phase space with a basis of Wannier functions

    Science.gov (United States)

    Fang, Yuan; Wu, Fan; Wu, Biao

    2018-02-01

    A quantum phase space with Wannier basis is constructed: (i) classical phase space is divided into Planck cells; (ii) a complete set of Wannier functions are constructed with the combination of Kohn’s method and Löwdin method such that each Wannier function is localized at a Planck cell. With these Wannier functions one can map a wave function unitarily onto phase space. Various examples are used to illustrate our method and compare it to Wigner function. The advantage of our method is that it can smooth out the oscillations in wave functions without losing any information and is potentially a better tool in studying quantum-classical correspondence. In addition, we point out that our method can be used for time-frequency analysis of signals.

  2. Partly occupied Wannier functions: Construction and applications

    DEFF Research Database (Denmark)

    Thygesen, Kristian Sommer; Hansen, Lars Bruno; Jacobsen, Karsten Wedel

    2005-01-01

    We have developed a practical scheme to construct partly occupied, maximally localized Wannier functions (WFs) for a wide range of systems. We explain and demonstrate how the inclusion of selected unoccupied states in the definition of the WFs can improve both their localization and symmetry...

  3. Compactly supported Wannier functions and algebraic K -theory

    Science.gov (United States)

    Read, N.

    2017-03-01

    In a tight-binding lattice model with n orbitals (single-particle states) per site, Wannier functions are n -component vector functions of position that fall off rapidly away from some location, and such that a set of them in some sense span all states in a given energy band or set of bands; compactly supported Wannier functions are such functions that vanish outside a bounded region. They arise not only in band theory, but also in connection with tensor-network states for noninteracting fermion systems, and for flat-band Hamiltonians with strictly short-range hopping matrix elements. In earlier work, it was proved that for general complex band structures (vector bundles) or general complex Hamiltonians—that is, class A in the tenfold classification of Hamiltonians and band structures—a set of compactly supported Wannier functions can span the vector bundle only if the bundle is topologically trivial, in any dimension d of space, even when use of an overcomplete set of such functions is permitted. This implied that, for a free-fermion tensor network state with a nontrivial bundle in class A, any strictly short-range parent Hamiltonian must be gapless. Here, this result is extended to all ten symmetry classes of band structures without additional crystallographic symmetries, with the result that in general the nontrivial bundles that can arise from compactly supported Wannier-type functions are those that may possess, in each of d directions, the nontrivial winding that can occur in the same symmetry class in one dimension, but nothing else. The results are obtained from a very natural usage of algebraic K -theory, based on a ring of polynomials in e±i kx,e±i ky,..., which occur as entries in the Fourier-transformed Wannier functions.

  4. Molecular transport calculations with Wannier Functions

    DEFF Research Database (Denmark)

    Thygesen, Kristian Sommer; Jacobsen, Karsten Wedel

    2005-01-01

    We present a scheme for calculating coherent electron transport in atomic-scale contacts. The method combines a formally exact Green's function formalism with a mean-field description of the electronic structure based on the Kohn-Sham scheme of density functional theory. We use an accurate plane...

  5. Bloch-Kohn and Wannier-Kohn functions in one dimension

    International Nuclear Information System (INIS)

    Bruno-Alfonso, Alexys; Guo-Qiang, Hai

    2003-01-01

    Bloch and Wannier functions of the Kohn type for a quite general one-dimensional Hamiltonian with inversion symmetry are studied. Important clarifications on null minigaps and the symmetry of those functions are given, with emphasis on the Kronig-Penney model. The lack of a general selection rule on the miniband index for optical transitions between edge states in semiconductor superlattices is discussed. A direct method for the calculation of Wannier-Kohn functions is presented

  6. Group Theory of Wannier Functions Providing the Basis for a Deeper Understanding of Magnetism and Superconductivity

    Directory of Open Access Journals (Sweden)

    Ekkehard Krüger

    2015-05-01

    Full Text Available The paper presents the group theory of optimally-localized and symmetry-adapted Wannier functions in a crystal of any given space group G or magnetic group M. Provided that the calculated band structure of the considered material is given and that the symmetry of the Bloch functions at all of the points of symmetry in the Brillouin zone is known, the paper details whether or not the Bloch functions of particular energy bands can be unitarily transformed into optimally-localized Wannier functions symmetry-adapted to the space group G, to the magnetic group M or to a subgroup of G or M. In this context, the paper considers usual, as well as spin-dependent Wannier functions, the latter representing the most general definition of Wannier functions. The presented group theory is a review of the theory published by one of the authors (Ekkehard Krüger in several former papers and is independent of any physical model of magnetism or superconductivity. However, it is suggested to interpret the special symmetry of the optimally-localized Wannier functions in the framework of a nonadiabatic extension of the Heisenberg model, the nonadiabatic Heisenberg model. On the basis of the symmetry of the Wannier functions, this model of strongly-correlated localized electrons makes clear predictions of whether or not the system can possess superconducting or magnetic eigenstates.

  7. The use of Wannier function in the calculations of band structure of covalent crystals

    International Nuclear Information System (INIS)

    Lu Dong; Yang Guang

    1985-10-01

    A variational procedure has been used to build up Wannier functions to study the energy bands of diamond, silicon and α-tin. For the case of silicon the Wannier function, density of charge and band structure are calculated self-consistently and a simple method in a non-self-consistent way has been used to compute the band structure of diamond, silicon and α-tin. The method seems to be effective to describe the electronic properties of covalent crystals. (author)

  8. On the construction of Wannier functions in topological insulators

    DEFF Research Database (Denmark)

    Cornean, Decebal Horia; Monaco, Domenico

    2017-01-01

    vanish, we provide an algorithm which constructs a “multi-step logarithm” that is employed to continuously deform the given family into a constant one, identically equal to the identity matrix. This algorithm leads to a constructive procedure to produce the composite Wannier bases mentioned above....

  9. Optimally localized Wannier functions for quasi one-dimensional nonperiodic insulators

    DEFF Research Database (Denmark)

    Cornean, Horia; Nenciu, A.; Nenciu, Gheorghe

    It is proved that for general, not necessarily periodic quasi one dimensional systems, the band position operator corresponding to an isolated part of the energy spectrum has discrete spectrum and its eigenfunctions have the same spatial localization as the corresponding spectral projection....... As a consequence, an eigenbasis of the band position operator provides a basis of optimally localized (generalized) Wannier functions for quasi one dimensional systems. If the system has some translation symmetries (e.g. usual translations, screw transformations), they are "inherited" bythe Wannier basis....

  10. Crystal field parameters with Wannier functions: application to rare-earth aluminates

    Czech Academy of Sciences Publication Activity Database

    Novák, Pavel; Knížek, Karel; Kuneš, Jan

    2013-01-01

    Roč. 87, č. 20 (2013), "205139-1"-"205139-7" ISSN 1098-0121 R&D Projects: GA ČR(CZ) GAP204/11/0713 Institutional support: RVO:68378271 Keywords : crystal-field * rare earths * Wannier functions Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.664, year: 2013 http://link.aps.org/doi/10.1103/PhysRevB.87.205139

  11. Optimally localized Wannier functions for quasi one-dimensional nonperiodic insulators

    DEFF Research Database (Denmark)

    Cornean, Horia; Nenciu, A.; Nenciu, Gheorghe

    2008-01-01

    It is proved that for general, not necessarily periodic, quasi one-dimensional systems the band position operator corresponding to an isolated part of the energy spectrum has discrete spectrum and its eigenfunctions have the same spatial localization as the corresponding spectral projection....... As a consequence, an eigenbasis of the band position operator provides a basis of optimally localized (generalized) Wannier functions for quasi one-dimensional systems, and this proves the strong Marzari-Vanderbilt conjecture. If the system has some translation symmetries (e.g. usual translations, screw...

  12. Electronic Transport Properties of One Dimensional Zno Nanowires Studied Using Maximally-Localized Wannier Functions

    Science.gov (United States)

    Sun, Xu; Gu, Yousong; Wang, Xueqiang

    2012-08-01

    One dimensional ZnO NWs with different diameters and lengths have been investigated using density functional theory (DFT) and Maximally Localized Wannier Functions (MLWFs). It is found that ZnO NWs are direct band gap semiconductors and there exist a turn on voltage for observable current. ZnO nanowires with different diameters and lengths show distinctive turn-on voltage thresholds in I-V characteristics curves. The diameters of ZnO NWs are greatly influent the transport properties of ZnO NWs. For the ZnO NW with large diameter that has more states and higher transmission coefficients leads to narrow band gap and low turn on voltage. In the case of thinner diameters, the length of ZnO NW can effects the electron tunneling and longer supercell lead to higher turn on voltage.

  13. woptic: Optical conductivity with Wannier functions and adaptive k-mesh refinement

    Czech Academy of Sciences Publication Activity Database

    Assmann, E.; Wissgott, P.; Kuneš, Jan; Toschi, A.; Blaha, P.; Held, K.

    2016-01-01

    Roč. 202, May (2016), s. 1-11 ISSN 0010-4655 Institutional support: RVO:68378271 Keywords : optical spectra * Wannier orbital Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.936, year: 2016

  14. Quasiparticle band structure of rocksalt-CdO determined using maximally localized Wannier functions.

    Science.gov (United States)

    Dixit, H; Lamoen, D; Partoens, B

    2013-01-23

    CdO in the rocksalt structure is an indirect band gap semiconductor. Thus, in order to determine its band gap one needs to calculate the complete band structure. However, in practice, the exact evaluation of the quasiparticle band structure for the large number of k-points which constitute the different symmetry lines in the Brillouin zone can be an extremely demanding task compared to the standard density functional theory (DFT) calculation. In this paper we report the full quasiparticle band structure of CdO using a plane-wave pseudopotential approach. In order to reduce the computational effort and time, we make use of maximally localized Wannier functions (MLWFs). The MLWFs offer a highly accurate method for interpolation of the DFT or GW band structure from a coarse k-point mesh in the irreducible Brillouin zone, resulting in a much reduced computational effort. The present paper discusses the technical details of the scheme along with the results obtained for the quasiparticle band gap and the electron effective mass.

  15. Studying the hopping parameters of half-Heusler NaAuS using maximally localized Wannier function

    Science.gov (United States)

    Sihi, Antik; Lal, Sohan; Pandey, Sudhir K.

    2018-04-01

    Here, the electronic behavior of half-Heusler NaAuS is studied using PBEsol exchange correlation functional by plotting the band structure curve. These bands are reproduced using maximally localized Wannier function using WANNIER90. Tight-binding bands are nicely matched with density functional theory bands. By fitting the tight-binding model, hopping parameter for NaAuS is obtained by including Na 2s, 2p, Au 6s, 5p, 5d and S 3s, 3p orbitals within the energy interval of -5 to 16 eV around the Fermi level. In present study, hopping integrals for NaAuS are computed for the first primitive unit cell atoms as well as the first nearest neighbor primitive unit cell. The most dominating hopping integrals are found for Na (3s) - S (3s), Na (2px) - S (2px), Au (6s) - S (3px), Au (6s) - S (3py) and Au (6s) - S (3pz) orbitals. The hopping integrals for the first nearest neighbor primitive unit cell are also discussed in this manuscript. In future, these hopping integrals are very important to find the topological invariant for NaAuS compound.

  16. First principles calculations for liquids and solids using maximally localized Wannier functions

    Science.gov (United States)

    Swartz, Charles W., VI

    The field of condensed matter computational physics has seen an explosion of applicability over the last 50+ years. Since the very first calculations with ENIAC and MANIAC the field has continued to pushed the boundaries of what is possible; from the first large-scale molecular dynamics simulation, to the implementation of Density Functional Theory and large scale Car-Parrinello molecular dynamics, to million-core turbulence calculations by Standford. These milestones represent not only technological advances but theoretical breakthroughs and algorithmic improvements as well. The work in this thesis was completed in the hopes of furthering such advancement, even by a small fraction. Here we will focus mainly on the calculation of electronic and structural properties of solids and liquids, where we shall implement a wide range of novel approaches that are both computational efficient and physically enlightening. To this end we routinely will work with maximally localized Wannier functions (MLWFs) which have recently seen a revival in mainstream scientific literature. MLWFs present us with interesting opportunity to calculate a localized orbital within the planewave formalism of atomistic simulations. Such a localization will prove to be invaluable in the construction of layer-based superlattice models, linear scaling hybrid functional schemes and model quasiparticle calculations. In the first application of MLWF we will look at modeling functional piezoelectricity in superlattices. Based on the locality principle of insulating superlattices, we apply the method of Wu et al to the piezoelectric strains of individual layers under iifixed displacement field. For a superlattice of arbitrary stacking sequence an accurate model is acquired for predicting piezoelectricity. By applying the model in the superlattices where ferroelectric and antiferrodistortive modes are in competition, functional piezoelectricity can be achieved. A strong nonlinear effect is observed and can

  17. Band selection and disentanglement using maximally localized Wannier functions: the cases of Co impurities in bulk copper and the Cu(111) surface

    Energy Technology Data Exchange (ETDEWEB)

    Korytar, Richard; Pruneda, Miguel; Ordejon, Pablo; Lorente, Nicolas [Centre d' Investigacio en Nanociencia i Nanotecnologia (CSIC-ICN), Campus de la UAB, E-08193 Bellaterra (Spain); Junquera, Javier, E-mail: rkorytar@cin2.e [Departamento de Ciencias de la Tierra y Fisica de la Materia Condensada, Universidad de Cantabria, E-39005 Santander (Spain)

    2010-09-29

    We have adapted the maximally localized Wannier function approach of Souza et al (2002 Phys. Rev. B 65 035109) to the density functional theory based SIESTA code (Soler et al 2002 J. Phys.: Condens. Mater. 14 2745) and applied it to the study of Co substitutional impurities in bulk copper as well as to the Cu(111) surface. In the Co impurity case, we have reduced the problem to the Co d-electrons and the Cu sp-band, permitting us to obtain an Anderson-like Hamiltonian from well defined density functional parameters in a fully orthonormal basis set. In order to test the quality of the Wannier approach to surfaces, we have studied the electronic structure of the Cu(111) surface by again transforming the density functional problem into the Wannier representation. An excellent description of the Shockley surface state is attained, permitting us to be confident in the application of this method to future studies of magnetic adsorbates in the presence of an extended surface state.

  18. Wannier-function-based constrained DFT with nonorthogonality-correcting Pulay forces in application to the reorganization effects in graphene-adsorbed pentacene

    Science.gov (United States)

    Roychoudhury, Subhayan; O'Regan, David D.; Sanvito, Stefano

    2018-05-01

    Pulay terms arise in the Hellmann-Feynman forces in electronic-structure calculations when one employs a basis set made of localized orbitals that move with their host atoms. If the total energy of the system depends on a subspace population defined in terms of the localized orbitals across multiple atoms, then unconventional Pulay terms will emerge due to the variation of the orbital nonorthogonality with ionic translation. Here, we derive the required exact expressions for such terms, which cannot be eliminated by orbital orthonormalization. We have implemented these corrected ionic forces within the linear-scaling density functional theory (DFT) package onetep, and we have used constrained DFT to calculate the reorganization energy of a pentacene molecule adsorbed on a graphene flake. The calculations are performed by including ensemble DFT, corrections for periodic boundary conditions, and empirical Van der Waals interactions. For this system we find that tensorially invariant population analysis yields an adsorbate subspace population that is very close to integer-valued when based upon nonorthogonal Wannier functions, and also but less precisely so when using pseudoatomic functions. Thus, orbitals can provide a very effective population analysis for constrained DFT. Our calculations show that the reorganization energy of the adsorbed pentacene is typically lower than that of pentacene in the gas phase. We attribute this effect to steric hindrance.

  19. Maximally localized Wannier functions in LaMnO3 within PBE + U, hybrid functionals and partially self-consistent GW: an efficient route to construct ab initio tight-binding parameters for eg perovskites.

    Science.gov (United States)

    Franchini, C; Kováčik, R; Marsman, M; Murthy, S Sathyanarayana; He, J; Ederer, C; Kresse, G

    2012-06-13

    Using the newly developed VASP2WANNIER90 interface we have constructed maximally localized Wannier functions (MLWFs) for the e(g) states of the prototypical Jahn-Teller magnetic perovskite LaMnO(3) at different levels of approximation for the exchange-correlation kernel. These include conventional density functional theory (DFT) with and without the additional on-site Hubbard U term, hybrid DFT and partially self-consistent GW. By suitably mapping the MLWFs onto an effective e(g) tight-binding (TB) Hamiltonian we have computed a complete set of TB parameters which should serve as guidance for more elaborate treatments of correlation effects in effective Hamiltonian-based approaches. The method-dependent changes of the calculated TB parameters and their interplay with the electron-electron (el-el) interaction term are discussed and interpreted. We discuss two alternative model parameterizations: one in which the effects of the el-el interaction are implicitly incorporated in the otherwise 'noninteracting' TB parameters and a second where we include an explicit mean-field el-el interaction term in the TB Hamiltonian. Both models yield a set of tabulated TB parameters which provide the band dispersion in excellent agreement with the underlying ab initio and MLWF bands.

  20. Adiabatic theory of Wannier threshold laws and ionization cross sections

    International Nuclear Information System (INIS)

    Macek, J.H.; Ovchinnikov, S.Y.

    1994-01-01

    Adiabatic energy eigenvalues of H 2 + are computed for complex values of the internuclear distance R. The infinite number of bound-state eigenenergies are represented by a function ε(R) that is single valued on a multisheeted Riemann surface. A region is found where ε(R) and the corresponding eigenfunctions exhibit harmonic-oscillator structure characteristic of electron motion on a potential saddle. The Schroedinger equation is solved in the adiabatic approximation along a path in the complex R plane to compute ionization cross sections. The cross section thus obtained joins the Wannier threshold region with the keV energy region, but the exponent near the ionization threshold disagrees with well-accepted values. Accepted values are obtained when a lowest-order diabatic correction is employed, indicating that adiabatic approximations do not give the correct zero velocity limit for ionization cross sections. Semiclassical eigenvalues for general top-of-barrier motion are given and the theory is applied to the ionization of atomic hydrogen by electron impact. The theory with a first diabatic correction gives the Wannier threshold law even for this case

  1. Raman-laser spectroscopy of Wannier-Stark states

    International Nuclear Information System (INIS)

    Tackmann, G.; Pelle, B.; Hilico, A.; Beaufils, Q.; Pereira dos Santos, F.

    2011-01-01

    Raman lasers are used as a spectroscopic probe of the state of atoms confined in a shallow one-dimensional (1D) vertical lattice. For sufficiently long laser pulses, resolved transitions in the bottom band of the lattice between Wannier Stark states corresponding to neighboring wells are observed. Couplings between such states are measured as a function of the lattice laser intensity and compared to theoretical predictions, from which the lattice depth can be extracted. Limits to the linewidth of these transitions are investigated. Transitions to higher bands can also be induced, as well as between transverse states for tilted Raman beams. All these features allow for a precise characterization of the trapping potential and for an efficient control of the atomic external degrees of freedom.

  2. Quasiparticle properties of DNA bases from GW calculations in a Wannier basis

    Science.gov (United States)

    Qian, Xiaofeng; Marzari, Nicola; Umari, Paolo

    2009-03-01

    The quasiparticle GW-Wannier (GWW) approach [1] has been recently developed to overcome the size limitations of conventional planewave GW calculations. By taking advantage of the localization properties of the maximally-localized Wannier functions and choosing a small set of polarization basis we reduce the number of Bloch wavefunctions products required for the evaluation of dynamical polarizabilities, and in turn greatly reduce memory requirements and computational efficiency. We apply GWW to study quasiparticle properties of different DNA bases and base-pairs, and solvation effects on the energy gap, demonstrating in the process the key advantages of this approach. [1] P. Umari,G. Stenuit, and S. Baroni, cond-mat/0811.1453

  3. Existence of the Stark-Wannier quantum resonances

    Energy Technology Data Exchange (ETDEWEB)

    Sacchetti, Andrea, E-mail: andrea.sacchetti@unimore.it [Department of Physics, Computer Sciences and Mathematics, University of Modena e Reggio Emilia, Modena (Italy)

    2014-12-15

    In this paper, we prove the existence of the Stark-Wannier quantum resonances for one-dimensional Schrödinger operators with smooth periodic potential and small external homogeneous electric field. Such a result extends the existence result previously obtained in the case of periodic potentials with a finite number of open gaps.

  4. Adiabatic theory of Wannier threshold laws and ionization cross sections

    International Nuclear Information System (INIS)

    Macek, J.H.; Ovchinnikov, S.Yu.

    1994-01-01

    The Wannier threshold law for three-particle fragmentation is reviewed. By integrating the Schroedinger equation along a path where the reaction coordinate R is complex, anharmonic corrections to the simple power law are obtained. These corrections are found to be non-analytic in the energy E, in contrast to the expected analytic dependence upon E

  5. Adiabatic theory of Wannier threshold laws and ionization cross sections

    International Nuclear Information System (INIS)

    Macek, J.H.; Ovchinnikov, S.Y.

    1995-01-01

    The Wannier threshold law for three-particle fragmentation is reviewed. By integrating the Schroedinger equation along a path where the reaction coordinate R is complex, anharmonic corrections to the simple power law are obtained. These corrections are found to be non-analytic in the energy E, in contrast to the expected analytic dependence upon E. copyright 1995 American Institute of Physics

  6. Wannier-Mott Excitons in Nanoscale Molecular Ices

    Science.gov (United States)

    Chen, Y.-J.; Muñoz Caro, G. M.; Aparicio, S.; Jiménez-Escobar, A.; Lasne, J.; Rosu-Finsen, A.; McCoustra, M. R. S.; Cassidy, A. M.; Field, D.

    2017-10-01

    The absorption of light to create Wannier-Mott excitons is a fundamental feature dictating the optical and photovoltaic properties of low band gap, high permittivity semiconductors. Such excitons, with an electron-hole separation an order of magnitude greater than lattice dimensions, are largely limited to these semiconductors but here we find evidence of Wannier-Mott exciton formation in solid carbon monoxide (CO) with a band gap of >8 eV and a low electrical permittivity. This is established through the observation that a change of a few degrees K in deposition temperature can shift the electronic absorption spectra of solid CO by several hundred wave numbers, coupled with the recent discovery that deposition of CO leads to the spontaneous formation of electric fields within the film. These so-called spontelectric fields, here approaching 4 ×107 V m-1 , are strongly temperature dependent. We find that a simple electrostatic model reproduces the observed temperature dependent spectral shifts based on the Stark effect on a hole and electron residing several nm apart, identifying the presence of Wannier-Mott excitons. The spontelectric effect in CO simultaneously explains the long-standing enigma of the sensitivity of vacuum ultraviolet spectra to the deposition temperature.

  7. Functional analysis

    CERN Document Server

    Kantorovich, L V

    1982-01-01

    Functional Analysis examines trends in functional analysis as a mathematical discipline and the ever-increasing role played by its techniques in applications. The theory of topological vector spaces is emphasized, along with the applications of functional analysis to applied analysis. Some topics of functional analysis connected with applications to mathematical economics and control theory are also discussed. Comprised of 18 chapters, this book begins with an introduction to the elements of the theory of topological spaces, the theory of metric spaces, and the theory of abstract measure space

  8. Surface Acoustic Analog of Bloch Oscillations, Wannier-Stark Ladders and Landau-Zener Tunneling

    Science.gov (United States)

    de Lima, M. M.; Kosevich, Yu. A.; Santos, P. V.; Cantarero, A.

    2011-12-01

    In this contribution, we discuss the recent experimental demonstration of Wannier-Stark ladders, Bloch Oscillations and Landau Zener tunneling in a solid by means of surface acoustic waves propagating through perturbed grating structures.

  9. Extension of the radiative lifetime of Wannier-Mott excitons in semiconductor nanoclusters

    International Nuclear Information System (INIS)

    Kukushkin, V. A.

    2015-01-01

    The purpose of the study is to calculate the radiative lifetime of Wannier-Mott excitons in three-dimensional potential wells formed of direct-gap narrow-gap semiconductor nanoclusters in wide-gap semiconductors and assumed to be large compared to the exciton radius. Calculations are carried out for the InAs/GaAs heterosystem. It is shown that, as the nanocluster dimensions are reduced to values on the order of the exciton radius, the exciton radiative lifetime becomes several times longer compared to that in a homogeneous semiconductor. The increase in the radiative lifetime is more pronounced at low temperatures. Thus, it is established that the placement of Wannier-Mott excitons into direct-gap semiconductor nanoclusters, whose dimensions are of the order of the exciton radius, can be used for considerable extension of the exciton radiative lifetime

  10. WannierTools: An open-source software package for novel topological materials

    Science.gov (United States)

    Wu, QuanSheng; Zhang, ShengNan; Song, Hai-Feng; Troyer, Matthias; Soluyanov, Alexey A.

    2018-03-01

    We present an open-source software package WannierTools, a tool for investigation of novel topological materials. This code works in the tight-binding framework, which can be generated by another software package Wannier90 (Mostofi et al., 2008). It can help to classify the topological phase of a given material by calculating the Wilson loop, and can get the surface state spectrum, which is detected by angle resolved photoemission (ARPES) and in scanning tunneling microscopy (STM) experiments. It also identifies positions of Weyl/Dirac points and nodal line structures, calculates the Berry phase around a closed momentum loop and Berry curvature in a part of the Brillouin zone (BZ).

  11. Phonon-assisted hopping of an electron on a Wannier-Stark ladder in a strong electric field

    International Nuclear Information System (INIS)

    Emin, D.; Hart, C.F.

    1987-01-01

    With the application of a spatially constant electric field, the degeneracy of electronic energy levels of geometrically equivalent sites of a crystal is generally lifted. As a result, the electric field causes the electronic eigenstates of a one-dimensional periodic chain to become localized. In particular, they are Wannier-Stark states. With sufficiently large electric-field strengths these states become sufficiently well localized that it becomes appropriate to consider electronic transport to occur via a succession of phonon-assisted hops between the localized Wannier-Stark states. In this paper, we present calculations of the drift velocity arising from acoustic- and optical-phonon-assisted hopping motion between Wannier-Stark states. When the intersite electronic transfer energy is sufficiently small so that the Wannier-Stark states are essentially each confined to a single atomic site, the transport reduces to that of a small polaron. In this regime, while the drift velocity initially rises with increasing electric field strength, the drift velocity ultimately falls with increasing electric-field strength at extremely large electric fields. More generally, for common values of the electronic bandwidth and electric field strength, the Wannier-Stark states span many sites. At sufficiently large electric fields, the energy separation between Wannier-Stark states exceeds the energy uncertainty associated with the carrier's interaction with phonons. Then, it is appropriate to treat the electronic transport in terms of phonon-assisted hopping between Wannier-Stark states. The resulting high-field drift velocity falls with increasing field strength in a series of steps. Thus, we find a structured negative differential mobility at large electric fields

  12. Functional Object Analysis

    DEFF Research Database (Denmark)

    Raket, Lars Lau

    We propose a direction it the field of statistics which we will call functional object analysis. This subfields considers the analysis of functional objects defined on continuous domains. In this setting we will focus on model-based statistics, with a particularly emphasis on mixed......-effect formulations, where the observed functional signal is assumed to consist of both fixed and random functional effects. This thesis takes the initial steps toward the development of likelihood-based methodology for functional objects. We first consider analysis of functional data defined on high...

  13. Functional analysis and applications

    CERN Document Server

    Siddiqi, Abul Hasan

    2018-01-01

    This self-contained textbook discusses all major topics in functional analysis. Combining classical materials with new methods, it supplies numerous relevant solved examples and problems and discusses the applications of functional analysis in diverse fields. The book is unique in its scope, and a variety of applications of functional analysis and operator-theoretic methods are devoted to each area of application. Each chapter includes a set of problems, some of which are routine and elementary, and some of which are more advanced. The book is primarily intended as a textbook for graduate and advanced undergraduate students in applied mathematics and engineering. It offers several attractive features making it ideally suited for courses on functional analysis intended to provide a basic introduction to the subject and the impact of functional analysis on applied and computational mathematics, nonlinear functional analysis and optimization. It introduces emerging topics like wavelets, Gabor system, inverse pro...

  14. Surface Acoustic Bloch Oscillations, the Wannier-Stark Ladder, and Landau-Zener Tunneling in a Solid

    Science.gov (United States)

    de Lima, M. M., Jr.; Kosevich, Yu. A.; Santos, P. V.; Cantarero, A.

    2010-04-01

    We present the experimental observation of Bloch oscillations, the Wannier-Stark ladder, and Landau-Zener tunneling of surface acoustic waves in perturbed grating structures on a solid substrate. A model providing a quantitative description of our experimental observations, including multiple Landau-Zener transitions of the anticrossed surface acoustic Wannier-Stark states, is developed. The use of a planar geometry for the realization of the Bloch oscillations and Landau-Zener tunneling allows a direct access to the elastic field distribution. The vertical surface displacement has been measured by interferometry.

  15. Functional data analysis

    CERN Document Server

    Ramsay, J O

    1997-01-01

    Scientists today collect samples of curves and other functional observations. This monograph presents many ideas and techniques for such data. Included are expressions in the functional domain of such classics as linear regression, principal components analysis, linear modelling, and canonical correlation analysis, as well as specifically functional techniques such as curve registration and principal differential analysis. Data arising in real applications are used throughout for both motivation and illustration, showing how functional approaches allow us to see new things, especially by exploiting the smoothness of the processes generating the data. The data sets exemplify the wide scope of functional data analysis; they are drwan from growth analysis, meterology, biomechanics, equine science, economics, and medicine. The book presents novel statistical technology while keeping the mathematical level widely accessible. It is designed to appeal to students, to applied data analysts, and to experienced researc...

  16. Fundamentals of functional analysis

    CERN Document Server

    Farenick, Douglas

    2016-01-01

    This book provides a unique path for graduate or advanced undergraduate students to begin studying the rich subject of functional analysis with fewer prerequisites than is normally required. The text begins with a self-contained and highly efficient introduction to topology and measure theory, which focuses on the essential notions required for the study of functional analysis, and which are often buried within full-length overviews of the subjects. This is particularly useful for those in applied mathematics, engineering, or physics who need to have a firm grasp of functional analysis, but not necessarily some of the more abstruse aspects of topology and measure theory normally encountered. The reader is assumed to only have knowledge of basic real analysis, complex analysis, and algebra. The latter part of the text provides an outstanding treatment of Banach space theory and operator theory, covering topics not usually found together in other books on functional analysis. Written in a clear, concise manner,...

  17. ARPES and NMTO Wannier Orbital Theory of Li{sub 0.9}Mo{sub 6}O{sub 17}

    Energy Technology Data Exchange (ETDEWEB)

    Dudy, L. [Physikalisches Institut, Universitaet Wuerzburg, D- 97074 Wuerzburg (Germany); Allen, J.W. [University of Michigan, Ann Arbor, MI (United States); Denlinger, J.D. [Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA (United States); He, J. [Clemson University, Clemson, SC (United States); Greenblatt, M. [Rutgers University, Piscataway, NJ (United States); Haverkort, M.W. [Max-Planck-Institut fuer Chemische Physik fester Stoffe, Dresden (Germany); Andersen, O.K.; Nohara, Y. [Max-Planck-Institut fuer Festkoerperphysik, Stuttgart (Germany)

    2015-07-01

    Li{sub 0.9}Mo{sub 6}O{sub 17} displays theoretically interesting metallic quasi-one dimensional (1D) behavior that is unusually robust against 3D crossover with decreasing temperature, and is characterized by a large value of anomalous exponent α∼ 0.6. We present very high resolution, low temperature (T=6K-30K) angle resolved photoemission spectroscopy (ARPES) of its band structure and Fermi surface (FS), analyzed with N-th order muffin tin orbital (NMTO) Wannier function band theory. We confirm a previous conclusion that LDA band theory is unusually successful, implying a small Hubbard U, and find in ARPES the dispersion and FS warping and splitting expected for predicted small and long range hoppings (t {sub perpendicular} {sub to} ∼ 10-15 meV) between chains.

  18. Applied functional analysis

    CERN Document Server

    Griffel, DH

    2002-01-01

    A stimulating introductory text, this volume examines many important applications of functional analysis to mechanics, fluid mechanics, diffusive growth, and approximation. Detailed enough to impart a thorough understanding, the text is also sufficiently straightforward for those unfamiliar with abstract analysis. Its four-part treatment begins with distribution theory and discussions of Green's functions. Essentially independent of the preceding material, the second and third parts deal with Banach spaces, Hilbert space, spectral theory, and variational techniques. The final part outlines the

  19. Wannier-Frenkel hybrid exciton in organic-semiconductor quantum dot heterostructures

    International Nuclear Information System (INIS)

    Birman, Joseph L.; Huong, Nguyen Que

    2007-01-01

    The formation of a hybridization state of Wannier Mott exciton and Frenkel exciton in different hetero-structure configurations involving quantum dots is investigated. The hybrid excitons exist at the interfaces of the semiconductors quantum dots and the organic medium, having unique properties and a large optical non-linearity. The coupling at resonance is very strong and tunable by changing the parameters of the systems (dot radius, dot-dot distance, generation of the organic dendrites and the materials of the system etc...). Different semiconductor quantum dot-organic material combination systems have been considered such as a semiconductor quantum dot lattice embedded in an organic host, a semiconductor quantum dot at the center of an organic dendrite, a semiconductor quantum dot coated by an organic shell

  20. Applied functional analysis

    CERN Document Server

    Oden, J Tinsley

    2010-01-01

    The textbook is designed to drive a crash course for beginning graduate students majoring in something besides mathematics, introducing mathematical foundations that lead to classical results in functional analysis. More specifically, Oden and Demkowicz want to prepare students to learn the variational theory of partial differential equations, distributions, and Sobolev spaces and numerical analysis with an emphasis on finite element methods. The 1996 first edition has been used in a rather intensive two-semester course. -Book News, June 2010

  1. Notes on functional analysis

    CERN Document Server

    Bhatia, Rajendra

    2009-01-01

    These notes are a record of a one semester course on Functional Analysis given by the author to second year Master of Statistics students at the Indian Statistical Institute, New Delhi. Students taking this course have a strong background in real analysis, linear algebra, measure theory and probability, and the course proceeds rapidly from the definition of a normed linear space to the spectral theorem for bounded selfadjoint operators in a Hilbert space. The book is organised as twenty six lectures, each corresponding to a ninety minute class session. This may be helpful to teachers planning a course on this topic. Well prepared students can read it on their own.

  2. Nonlinear functional analysis

    CERN Document Server

    Deimling, Klaus

    1985-01-01

    topics. However, only a modest preliminary knowledge is needed. In the first chapter, where we introduce an important topological concept, the so-called topological degree for continuous maps from subsets ofRn into Rn, you need not know anything about functional analysis. Starting with Chapter 2, where infinite dimensions first appear, one should be familiar with the essential step of consider­ ing a sequence or a function of some sort as a point in the corresponding vector space of all such sequences or functions, whenever this abstraction is worthwhile. One should also work out the things which are proved in § 7 and accept certain basic principles of linear functional analysis quoted there for easier references, until they are applied in later chapters. In other words, even the 'completely linear' sections which we have included for your convenience serve only as a vehicle for progress in nonlinearity. Another point that makes the text introductory is the use of an essentially uniform mathematical languag...

  3. (Non-)Abelian Kramers-Wannier duality and topological field theory

    CERN Document Server

    Severa, Pavol

    2002-01-01

    We study a connection between duality and topological field theories. First, 2d Kramers-Wannier duality is formulated as a simple 3d topological claim (more or less Poincare duality), and a similar formulation is given for higher-dimensional cases. In this form they lead to simple TFTs with boundary coloured in two colours. The statistical models live on the boundary of these TFTs, as in the CS/WZW or AdS/CFT correspondence. Classical models (Poisson-Lie T-duality) suggest a non-abelian generalization in the 2dcase, with abelian groups replaced by quantum groups. Amazingly, the TFT formulation solves the problem without computation: quantum groups appear in pictures, independently of the classical motivation. Connection with Chern-Simons theory appears at the symplectic level, and also in the pictures of the Drinfeld double: Reshetikhin-Turaev invariants of links in 3-manifolds, computed from the double, are included in these TFTs. All this suggests nice phenomena in higher dimensions.

  4. A Primer on Functional Analysis

    Science.gov (United States)

    Yoman, Jerome

    2008-01-01

    This article presents principles and basic steps for practitioners to complete a functional analysis of client behavior. The emphasis is on application of functional analysis to adult mental health clients. The article includes a detailed flow chart containing all major functional diagnoses and behavioral interventions, with functional assessment…

  5. Strange functions in real analysis

    CERN Document Server

    Kharazishvili, AB

    2005-01-01

    Weierstrass and Blancmange nowhere differentiable functions, Lebesgue integrable functions with everywhere divergent Fourier series, and various nonintegrable Lebesgue measurable functions. While dubbed strange or "pathological," these functions are ubiquitous throughout mathematics and play an important role in analysis, not only as counterexamples of seemingly true and natural statements, but also to stimulate and inspire the further development of real analysis.Strange Functions in Real Analysis explores a number of important examples and constructions of pathological functions. After introducing the basic concepts, the author begins with Cantor and Peano-type functions, then moves to functions whose constructions require essentially noneffective methods. These include functions without the Baire property, functions associated with a Hamel basis of the real line, and Sierpinski-Zygmund functions that are discontinuous on each subset of the real line having the cardinality continuum. Finally, he considers e...

  6. Crystal field and magnetism with Wannier functions: rare-earth dopedaluminum garnets

    Czech Academy of Sciences Publication Activity Database

    Mihóková, Eva; Novák, Pavel; Laguta, Valentyn

    2015-01-01

    Roč. 33, č. 12 (2015), 1316-1323 ISSN 1002-0721 R&D Projects: GA ČR GA13-09876S Institutional support: RVO:68378271 Keywords : crystal field * ab initio calculations * garnets * rare earths Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.188, year: 2015

  7. Crystal field and magnetism with Wannier functions: Orthorhombic rare-earth manganites

    Czech Academy of Sciences Publication Activity Database

    Novák, Pavel; Nekvasil, Vladimír; Knížek, Karel

    358-359, MAY (2014), s. 228-232 ISSN 0304-8853 R&D Projects: GA ČR GA13-25251S Institutional support: RVO:68378271 Keywords : crystal field * rare- earth magnetism Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.970, year: 2014

  8. Interband optical absorption in the Wannier-Stark ladder under the electron-LO-phonon resonance condition

    International Nuclear Information System (INIS)

    Govorov, A.O.

    1993-08-01

    Interband optical absorption in the Wannier-Stark ladder in the presence of the electron-LO-phonon resonance is investigated theoretically. The electron-LO-phonon resonance occurs when the energy spacing between adjacent Stark-ladder levels coincides with the LO-phonon energy. We propose a model describing the polaron effect in a superlattice. Calculations show that the absorption line shape is strongly modified due to the polaron effect under the electron-LO-phonon resonance condition. We consider optical phenomena in a normal magnetic field that leads to enhancement of polaron effects. (author). 17 refs, 5 figs

  9. Theoretical numerical analysis a functional analysis framework

    CERN Document Server

    Atkinson, Kendall

    2005-01-01

    This textbook prepares graduate students for research in numerical analysis/computational mathematics by giving to them a mathematical framework embedded in functional analysis and focused on numerical analysis. This helps the student to move rapidly into a research program. The text covers basic results of functional analysis, approximation theory, Fourier analysis and wavelets, iteration methods for nonlinear equations, finite difference methods, Sobolev spaces and weak formulations of boundary value problems, finite element methods, elliptic variational inequalities and their numerical solu

  10. Functional Analysis in Interdisciplinary Applications

    CERN Document Server

    Nursultanov, Erlan; Ruzhansky, Michael; Sadybekov, Makhmud

    2017-01-01

    This volume presents current research in functional analysis and its applications to a variety of problems in mathematics and mathematical physics. The book contains over forty carefully refereed contributions to the conference “Functional Analysis in Interdisciplinary Applications” (Astana, Kazakhstan, October 2017). Topics covered include the theory of functions and functional spaces; differential equations and boundary value problems; the relationship between differential equations, integral operators and spectral theory; and mathematical methods in physical sciences. Presenting a wide range of topics and results, this book will appeal to anyone working in the subject area, including researchers and students interested to learn more about different aspects and applications of functional analysis.

  11. Edge-entanglement spectrum correspondence in a nonchiral topological phase and Kramers-Wannier duality

    Science.gov (United States)

    Ho, Wen Wei; Cincio, Lukasz; Moradi, Heidar; Gaiotto, Davide; Vidal, Guifre

    2015-03-01

    cut are governed by Kramers-Wannier self-dual Hamiltonians, in addition to them being Z2 symmetric, which is imposed by the topological order. Thus, by considering the Wen-plaquette model as a SET, the topological order in the bulk together with the translation invariance of the perturbations along the edge/cut imply an edge-ES correspondence at least in some finite domain in Hamiltonian space.

  12. Functional Group Analysis.

    Science.gov (United States)

    Smith, Walter T., Jr.; Patterson, John M.

    1984-01-01

    Literature on analytical methods related to the functional groups of 17 chemical compounds is reviewed. These compounds include acids, acid azides, alcohols, aldehydes, ketones, amino acids, aromatic hydrocarbons, carbodiimides, carbohydrates, ethers, nitro compounds, nitrosamines, organometallic compounds, peroxides, phenols, silicon compounds,…

  13. Automatic Functional Harmonic Analysis

    NARCIS (Netherlands)

    de Haas, W.B.; Magalhães, J.P.; Wiering, F.; Veltkamp, R.C.

    2013-01-01

    Music scholars have been studying tonal harmony intensively for centuries, yielding numerous theories and models. Unfortunately, a large number of these theories are formulated in a rather informal fashion and lack mathematical precision. In this article we present HarmTrace, a functional model of

  14. Elementary functional analysis

    CERN Document Server

    Shilov, Georgi E

    1996-01-01

    Introductory text covers basic structures of mathematical analysis (linear spaces, metric spaces, normed linear spaces, etc.), differential equations, orthogonal expansions, Fourier transforms - including problems in the complex domain, especially involving the Laplace transform - and more. Each chapter includes a set of problems, with hints and answers. Bibliography. 1974 edition.

  15. Functional Generalized Structured Component Analysis.

    Science.gov (United States)

    Suk, Hye Won; Hwang, Heungsun

    2016-12-01

    An extension of Generalized Structured Component Analysis (GSCA), called Functional GSCA, is proposed to analyze functional data that are considered to arise from an underlying smooth curve varying over time or other continua. GSCA has been geared for the analysis of multivariate data. Accordingly, it cannot deal with functional data that often involve different measurement occasions across participants and a large number of measurement occasions that exceed the number of participants. Functional GSCA addresses these issues by integrating GSCA with spline basis function expansions that represent infinite-dimensional curves onto a finite-dimensional space. For parameter estimation, functional GSCA minimizes a penalized least squares criterion by using an alternating penalized least squares estimation algorithm. The usefulness of functional GSCA is illustrated with gait data.

  16. Transform analysis of generalized functions

    CERN Document Server

    Misra, O P

    1986-01-01

    Transform Analysis of Generalized Functions concentrates on finite parts of integrals, generalized functions and distributions. It gives a unified treatment of the distributional setting with transform analysis, i.e. Fourier, Laplace, Stieltjes, Mellin, Hankel and Bessel Series.Included are accounts of applications of the theory of integral transforms in a distributional setting to the solution of problems arising in mathematical physics. Information on distributional solutions of differential, partial differential equations and integral equations is conveniently collected here.The volume will

  17. Functional Analysis in Virtual Environments

    Science.gov (United States)

    Vasquez, Eleazar, III; Marino, Matthew T.; Donehower, Claire; Koch, Aaron

    2017-01-01

    Functional analysis (FA) is an assessment procedure involving the systematic manipulation of an individual's environment to determine why a target behavior is occurring. An analog FA provides practitioners the opportunity to manipulate variables in a controlled environment and formulate a hypothesis for the function of a behavior. In previous…

  18. Functional and shape data analysis

    CERN Document Server

    Srivastava, Anuj

    2016-01-01

    This textbook for courses on function data analysis and shape data analysis describes how to define, compare, and mathematically represent shapes, with a focus on statistical modeling and inference. It is aimed at graduate students in analysis in statistics, engineering, applied mathematics, neuroscience, biology, bioinformatics, and other related areas. The interdisciplinary nature of the broad range of ideas covered—from introductory theory to algorithmic implementations and some statistical case studies—is meant to familiarize graduate students with an array of tools that are relevant in developing computational solutions for shape and related analyses. These tools, gleaned from geometry, algebra, statistics, and computational science, are traditionally scattered across different courses, departments, and disciplines; Functional and Shape Data Analysis offers a unified, comprehensive solution by integrating the registration problem into shape analysis, better preparing graduate students for handling fu...

  19. Functional Analysis of Metabolomics Data.

    Science.gov (United States)

    Chagoyen, Mónica; López-Ibáñez, Javier; Pazos, Florencio

    2016-01-01

    Metabolomics aims at characterizing the repertory of small chemical compounds in a biological sample. As it becomes more massive and larger sets of compounds are detected, a functional analysis is required to convert these raw lists of compounds into biological knowledge. The most common way of performing such analysis is "annotation enrichment analysis," also used in transcriptomics and proteomics. This approach extracts the annotations overrepresented in the set of chemical compounds arisen in a given experiment. Here, we describe the protocols for performing such analysis as well as for visualizing a set of compounds in different representations of the metabolic networks, in both cases using free accessible web tools.

  20. Wavelets in functional data analysis

    CERN Document Server

    Morettin, Pedro A; Vidakovic, Brani

    2017-01-01

    Wavelet-based procedures are key in many areas of statistics, applied mathematics, engineering, and science. This book presents wavelets in functional data analysis, offering a glimpse of problems in which they can be applied, including tumor analysis, functional magnetic resonance and meteorological data. Starting with the Haar wavelet, the authors explore myriad families of wavelets and how they can be used. High-dimensional data visualization (using Andrews' plots), wavelet shrinkage (a simple, yet powerful, procedure for nonparametric models) and a selection of estimation and testing techniques (including a discussion on Stein’s Paradox) make this a highly valuable resource for graduate students and experienced researchers alike.

  1. Fifteen papers on functional analysis

    CERN Document Server

    Allakhverdiev, B P; Fainshtein, A S; Khelemskii, AYa; Klenina, LI

    1984-01-01

    The papers in this volume cover topics on functional analysis. They have been selected, translated, and edited from publications not otherwise translated into English under the auspices of the AMS-ASL-IMS Committee on Translations from Russian and Other Foreign Languages.

  2. Static Analysis of Functional Programs

    NARCIS (Netherlands)

    van den Berg, Klaas; van den Broek, P.M.

    1994-01-01

    In this paper, the static analysis of programs in the functional programming language Miranda is described based on two graph models. A new control-flow graph model of Miranda definitions is presented, and a model with four classes of caligraphs. Standard software metrics are applicable to these

  3. Higher-dimensional Wannier Interpolation for the Modern Theory of the Dzyaloshinskii-Moriya Interaction: Application to Co-based Trilayers

    Science.gov (United States)

    Hanke, Jan-Philipp; Freimuth, Frank; Blügel, Stefan; Mokrousov, Yuriy

    2018-04-01

    We present an advanced first-principles formalism to evaluate the Dzyaloshinskii-Moriya interaction (DMI) in its modern theory as well as Berry curvatures in complex spaces based on a higher-dimensional Wannier interpolation. Our method is applied to the Co-based trilayer systems IrδPt1-δ/Co/Pt and AuγPt1-γ/Co/Pt, where we gain insights into the correlations between the electronic structure and the DMI, and we uncover prominent sign changes of the chiral interaction with the overlayer composition. Beyond the discussed phenomena, the scope of applications of our Wannier-based scheme is particularly broad as it is ideally suited to study efficiently the Hamiltonian evolution under the slow variation of very general parameters.

  4. Function analysis of unknown genes

    DEFF Research Database (Denmark)

    Rogowska-Wrzesinska, A.

    2002-01-01

      This thesis entitled "Function analysis of unknown genes" presents the use of proteome analysis for the characterisation of yeast (Saccharomyces cerevisiae) genes and their products (proteins especially those of unknown function). This study illustrates that proteome analysis can be used...... to describe different aspects of molecular biology of the cell, to study changes that occur in the cell due to overexpression or deletion of a gene and to identify various protein modifications. The biological questions and the results of the described studies show the diversity of the information that can...... genes and proteins. It reports the first global proteome database collecting 36 yeast single gene deletion mutants and selecting over 650 differences between analysed mutants and the wild type strain. The obtained results show that two-dimensional gel electrophoresis and mass spectrometry based proteome...

  5. EVENT PLANNING USING FUNCTION ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    Lori Braase; Jodi Grgich

    2011-06-01

    Event planning is expensive and resource intensive. Function analysis provides a solid foundation for comprehensive event planning (e.g., workshops, conferences, symposiums, or meetings). It has been used at Idaho National Laboratory (INL) to successfully plan events and capture lessons learned, and played a significant role in the development and implementation of the “INL Guide for Hosting an Event.” Using a guide and a functional approach to planning utilizes resources more efficiently and reduces errors that could be distracting or detrimental to an event. This integrated approach to logistics and program planning – with the primary focus on the participant – gives us the edge.

  6. Functional analysis theory and applications

    CERN Document Server

    Edwards, RE

    2011-01-01

    ""The book contains an enormous amount of information - mathematical, bibliographical and historical - interwoven with some outstanding heuristic discussions."" - Mathematical Reviews.In this massive graduate-level study, Emeritus Professor Edwards (Australian National University, Canberra) presents a balanced account of both the abstract theory and the applications of linear functional analysis. Written for readers with a basic knowledge of set theory, general topology, and vector spaces, the book includes an abundance of carefully chosen illustrative examples and excellent exercises at the

  7. B Plant function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate B Plant

  8. Functional Multiple-Set Canonical Correlation Analysis

    Science.gov (United States)

    Hwang, Heungsun; Jung, Kwanghee; Takane, Yoshio; Woodward, Todd S.

    2012-01-01

    We propose functional multiple-set canonical correlation analysis for exploring associations among multiple sets of functions. The proposed method includes functional canonical correlation analysis as a special case when only two sets of functions are considered. As in classical multiple-set canonical correlation analysis, computationally, the…

  9. Gaussian process regression analysis for functional data

    CERN Document Server

    Shi, Jian Qing

    2011-01-01

    Gaussian Process Regression Analysis for Functional Data presents nonparametric statistical methods for functional regression analysis, specifically the methods based on a Gaussian process prior in a functional space. The authors focus on problems involving functional response variables and mixed covariates of functional and scalar variables.Covering the basics of Gaussian process regression, the first several chapters discuss functional data analysis, theoretical aspects based on the asymptotic properties of Gaussian process regression models, and new methodological developments for high dime

  10. Interpretable functional principal component analysis.

    Science.gov (United States)

    Lin, Zhenhua; Wang, Liangliang; Cao, Jiguo

    2016-09-01

    Functional principal component analysis (FPCA) is a popular approach to explore major sources of variation in a sample of random curves. These major sources of variation are represented by functional principal components (FPCs). The intervals where the values of FPCs are significant are interpreted as where sample curves have major variations. However, these intervals are often hard for naïve users to identify, because of the vague definition of "significant values". In this article, we develop a novel penalty-based method to derive FPCs that are only nonzero precisely in the intervals where the values of FPCs are significant, whence the derived FPCs possess better interpretability than the FPCs derived from existing methods. To compute the proposed FPCs, we devise an efficient algorithm based on projection deflation techniques. We show that the proposed interpretable FPCs are strongly consistent and asymptotically normal under mild conditions. Simulation studies confirm that with a competitive performance in explaining variations of sample curves, the proposed FPCs are more interpretable than the traditional counterparts. This advantage is demonstrated by analyzing two real datasets, namely, electroencephalography data and Canadian weather data. © 2015, The International Biometric Society.

  11. Functional 2D Procrustes Shape Analysis

    DEFF Research Database (Denmark)

    Larsen, Rasmus

    2005-01-01

    Using a landmark based approach to Procrustes alignment neglects the functional nature of outlines and surfaces. In order to re-introduce this functional nature into the analysis we will consider alignment of shapes with functional representations. First functional Procrustes analysis of curve...

  12. Nearly Perfect Triplet-Triplet Energy Transfer from Wannier Excitons to Naphthalene in Organic-Inorganic Hybrid Quantum-Well Materials

    Science.gov (United States)

    Ema, K.; Inomata, M.; Kato, Y.; Kunugita, H.; Era, M.

    2008-06-01

    We report the observation of extremely efficient energy transfer (greater than 99%) in an organic-inorganic hybrid quantum-well structure consisting of perovskite-type lead bromide well layers and naphthalene-linked ammonium barrier layers. Time-resolved photoluminescence measurements confirm that the transfer is triplet-triplet Dexter-type energy transfer from Wannier excitons in the inorganic well to the triplet state of naphthalene molecules in the organic barrier. Using measurements in the 10 300 K temperature range, we also investigated the temperature dependence of the energy transfer.

  13. Functional Analysis and Treatment of Nail Biting

    Science.gov (United States)

    Dufrene, Brad A.; Watson, T. Steuart; Kazmerski, Jennifer S.

    2008-01-01

    This study applied functional analysis methodology to nail biting exhibited by a 24-year-old female graduate student. Results from the brief functional analysis indicated variability in nail biting across assessment conditions. Functional analysis data were then used to guide treatment development and implementation. Treatment included a…

  14. Absolute 3PO triple differential cross sections for electron-helium Wannier threshold ionisation

    International Nuclear Information System (INIS)

    Carruthers, D.R.J.; Crothers, D.S.F.

    1992-01-01

    The uniform semiclassical approximation of Crothers is employed to find a final-state 3 P O wave function for threshold electron impact ionisation of helium. The Kohn variational principle is applied perturbatively to evaluate the scattering amplitude and hence the absolute 3 P O contribution to the triple differential cross sections. These plus the previous absolute singlet results of Crothers are compared favourably with the relative experimental results of Selles et al. (orig.)

  15. Functional analysis and treatment of diurnal bruxism.

    Science.gov (United States)

    Lang, Russell; Davenport, Katy; Britt, Courtney; Ninci, Jennifer; Garner, Jennifer; Moore, Melissa

    2013-01-01

    An analogue functional analysis identified attention as a function for a 5-year-old boy's bruxism (teeth grinding). Functional communication training resulted in a reduction of bruxism and an increase in alternative mands for attention. Results were maintained 3 weeks following the intervention. © Society for the Experimental Analysis of Behavior.

  16. Functional Techniques for Data Analysis

    Science.gov (United States)

    Tomlinson, John R.

    1997-01-01

    This dissertation develops a new general method of solving Prony's problem. Two special cases of this new method have been developed previously. They are the Matrix Pencil and the Osculatory Interpolation. The dissertation shows that they are instances of a more general solution type which allows a wide ranging class of linear functional to be used in the solution of the problem. This class provides a continuum of functionals which provide new methods that can be used to solve Prony's problem.

  17. Functional analysis of controbloc incidents

    International Nuclear Information System (INIS)

    Gouffon, A.; Jorel, M.

    1992-11-01

    The subject of the present paper is the survey jointly carried out in 1989 by the IPSN Safety Analysis Department and the Firm BERTIN and Co. on significant incidents related to the Controbloc system equipping the EDF 1300 MWe PWR power plants in France. This survey consisted in a general review of Controbloc operating problems, together with analysis of the safety consequences of the incidents discussed. The survey enabled improvements to be recommended in this respect and provided a basis for safety analysis

  18. Assessment of right atrial function analysis

    International Nuclear Information System (INIS)

    Shohgase, Takashi; Miyamoto, Atsushi; Kanamori, Katsushi; Kobayashi, Takeshi; Yasuda, Hisakazu

    1988-01-01

    To assess the potential utility of right atrial function analysis in cardiac disease, reservoir function, pump function, and right atrial peak emptying rate (RAPER) were compared in 10 normal subjects, 32 patients with coronary artery disease, and 4 patients with primary pulmonary hypertension. Right atrial volume curves were obtained using cardiac radionuclide method with Kr-81m. In normal subjects, reservoir function index was 0.41+-0.05; pump function index was 0.25+-0.05. Both types of patients has decreased reservoir funcion and increased pump function. Pump function tended to decrease with an increase of right ventricular end-diastolic pressure. RAPER correlated well with right ventricular peak filling rate, probably reflecting right ventricular diastolic function. Analysis of right atrial function seemed to be of value in evaluating factors regulating right ventricular contraction and diastolic function, and cardiac output. (Namekawa, K)

  19. Basic methods of linear functional analysis

    CERN Document Server

    Pryce, John D

    2011-01-01

    Introduction to the themes of mathematical analysis, geared toward advanced undergraduate and graduate students. Topics include operators, function spaces, Hilbert spaces, and elementary Fourier analysis. Numerous exercises and worked examples.1973 edition.

  20. Functional Analysis of Kori Unit 1

    International Nuclear Information System (INIS)

    Choi, Seong Soo; Han, Jeong Hyun; Heo, Tae Young

    2009-07-01

    Function Analysis of Kori Unit 1 has been performed as a part of independent human factors review tasks for control room renovation of the plant. The top level goal defined for the scope of function analysis is 'Generate Electricity'. Through this function analysis of Kori Unit 1, the detailed sub-functions extracted from the existing design documents and procedures, functional relationships among the high level functions, functional classification of each hierarchical level, and tree diagrams of the hierarchical function structures of the plant were developed and identified as the result of the project. In addition, we investigated and compiled the specifications of MMIS devices used in Ulchin Nuclear Power Plant Unit 5,6 in accordance with the request from KAERI. The results of those researches will be used as basis data for independent review of the control room MMIS design of the Kori Unit 1

  1. Functional analysis, spectral theory, and applications

    CERN Document Server

    Einsiedler, Manfred

    2017-01-01

    This textbook provides a careful treatment of functional analysis and some of its applications in analysis, number theory, and ergodic theory. In addition to discussing core material in functional analysis, the authors cover more recent and advanced topics, including Weyl’s law for eigenfunctions of the Laplace operator, amenability and property (T), the measurable functional calculus, spectral theory for unbounded operators, and an account of Tao’s approach to the prime number theorem using Banach algebras. The book further contains numerous examples and exercises, making it suitable for both lecture courses and self-study. Functional Analysis, Spectral Theory, and Applications is aimed at postgraduate and advanced undergraduate students with some background in analysis and algebra, but will also appeal to everyone with an interest in seeing how functional analysis can be applied to other parts of mathematics.

  2. Differential analysis of matrix convex functions II

    DEFF Research Database (Denmark)

    Hansen, Frank; Tomiyama, Jun

    2009-01-01

    We continue the analysis in [F. Hansen, and J. Tomiyama, Differential analysis of matrix convex functions. Linear Algebra Appl., 420:102--116, 2007] of matrix convex functions of a fixed order defined in a real interval by differential methods as opposed to the characterization in terms of divided...

  3. Basic Functional Analysis Puzzles of Spectral Flow

    DEFF Research Database (Denmark)

    Booss-Bavnbek, Bernhelm

    2011-01-01

    We explain an array of basic functional analysis puzzles on the way to general spectral flow formulae and indicate a direction of future topological research for dealing with these puzzles.......We explain an array of basic functional analysis puzzles on the way to general spectral flow formulae and indicate a direction of future topological research for dealing with these puzzles....

  4. Functional Analysis and Reduction of Inappropriate Spitting

    Science.gov (United States)

    Carter, Stacy L.; Wheeler, John J.

    2007-01-01

    Functional analysis was used to determine the possible function of inappropriate spitting behavior of an adult woman who had been diagnosed with profound mental retardation. Results of an initial descriptive assessment indicated a possible attention function and led to an attention-based intervention, which was deemed ineffective at reducing the…

  5. Functional analysis in MR urography - made simple

    Energy Technology Data Exchange (ETDEWEB)

    Khrichenko, Dmitry; Darge, Kassa [Children' s Hospital of Philadelphia, Department of Radiology, Philadelphia, PA (United States)

    2010-02-15

    MR urography (MRU) has proved to be a most advantageous imaging modality of the urinary tract in children, providing one-stop comprehensive morphological and functional information, without the utilization of ionizing radiation. The functional analysis of the MRU scan still requires external post-processing using relatively complex software. This has proved to be a limiting factor in widespread routine implementation of MRU functional analysis and use of MRU functional parameters similar to nuclear medicine. We present software, developed in a pediatric radiology department, that not only enables comprehensive automated functional analysis, but is also very user-friendly, fast, easily operated by the average radiologist or MR technician and freely downloadable Virtual Machine is required for the installation, which is obtained at no charge. The analysis software, known as ''CHOP-fMRU,'' has the potential to help overcome the obstacles to widespread use of functional MRU in children. (orig.)

  6. Linear functional analysis for scientists and engineers

    CERN Document Server

    Limaye, Balmohan V

    2016-01-01

    This book provides a concise and meticulous introduction to functional analysis. Since the topic draws heavily on the interplay between the algebraic structure of a linear space and the distance structure of a metric space, functional analysis is increasingly gaining the attention of not only mathematicians but also scientists and engineers. The purpose of the text is to present the basic aspects of functional analysis to this varied audience, keeping in mind the considerations of applicability. A novelty of this book is the inclusion of a result by Zabreiko, which states that every countably subadditive seminorm on a Banach space is continuous. Several major theorems in functional analysis are easy consequences of this result. The entire book can be used as a textbook for an introductory course in functional analysis without having to make any specific selection from the topics presented here. Basic notions in the setting of a metric space are defined in terms of sequences. These include total boundedness, c...

  7. Lessons learned in applying function analysis

    International Nuclear Information System (INIS)

    Mitchel, G.R.; Davey, E.; Basso, R.

    2001-01-01

    This paper summarizes the lessons learned in undertaking and applying function analysis based on the recent experience of utility, AECL and international design and assessment projects. Function analysis is an analytical technique that can be used to characterize and asses the functions of a system and is widely recognized as an essential component of a 'systematic' approach to design, on that integrated operational and user requirements into the standard design process. (author)

  8. Wannier threshold theory for the description of the two-electron cusp in the ion-induced double ionization of atoms

    Energy Technology Data Exchange (ETDEWEB)

    Barrachina, R.O., E-mail: barra@cab.cnea.gov.ar [Centro Atómico Bariloche and Instituto Balseiro, Comisíon Nacional de Energía Atómica and Universidad Nacional de Cuyo, 8400 Bariloche, Río Negro (Argentina); Gulyás, L.; Sarkadi, L. [Institute for Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), Pf. 51, H-4001 Debrecen (Hungary)

    2016-02-15

    The double electron capture into the continuum states of the projectile (double ECC) is investigated theoretically in collisions of 100 keV He{sup 2+} ions with He atoms. The process is described within the framework of the impact parameter and frozen-correlation approximations where the single-electron events are treated by the continuum distorted wave method. On the other hand, the Wannier theory is employed for describing the angular correlation between both ejected electrons. This treatment substantially improved the agreement between the theory and experiment as compared to the previous version of the theory (Gulyás et al., 2010) in which the correlation between the ejected electrons was taken into account by the Coulomb density of states approximation.

  9. Transfer function analysis of radiographic imaging systems

    International Nuclear Information System (INIS)

    Metz, C.E.; Doi, K.

    1979-01-01

    The theoretical and experimental aspects of the techniques of transfer function analysis used in radiographic imaging systems are reviewed. The mathematical principles of transfer function analysis are developed for linear, shift-invariant imaging systems, for the relation between object and image and for the image due to a sinusoidal plane wave object. The other basic mathematical principle discussed is 'Fourier analysis' and its application to an input function. Other aspects of transfer function analysis included are alternative expressions for the 'optical transfer function' of imaging systems and expressions are derived for both serial and parallel transfer image sub-systems. The applications of transfer function analysis to radiographic imaging systems are discussed in relation to the linearisation of the radiographic imaging system, the object, the geometrical unsharpness, the screen-film system unsharpness, other unsharpness effects and finally noise analysis. It is concluded that extensive theoretical, computer simulation and experimental studies have demonstrated that the techniques of transfer function analysis provide an accurate and reliable means for predicting and understanding the effects of various radiographic imaging system components in most practical diagnostic medical imaging situations. (U.K.)

  10. FGWAS: Functional genome wide association analysis.

    Science.gov (United States)

    Huang, Chao; Thompson, Paul; Wang, Yalin; Yu, Yang; Zhang, Jingwen; Kong, Dehan; Colen, Rivka R; Knickmeyer, Rebecca C; Zhu, Hongtu

    2017-10-01

    Functional phenotypes (e.g., subcortical surface representation), which commonly arise in imaging genetic studies, have been used to detect putative genes for complexly inherited neuropsychiatric and neurodegenerative disorders. However, existing statistical methods largely ignore the functional features (e.g., functional smoothness and correlation). The aim of this paper is to develop a functional genome-wide association analysis (FGWAS) framework to efficiently carry out whole-genome analyses of functional phenotypes. FGWAS consists of three components: a multivariate varying coefficient model, a global sure independence screening procedure, and a test procedure. Compared with the standard multivariate regression model, the multivariate varying coefficient model explicitly models the functional features of functional phenotypes through the integration of smooth coefficient functions and functional principal component analysis. Statistically, compared with existing methods for genome-wide association studies (GWAS), FGWAS can substantially boost the detection power for discovering important genetic variants influencing brain structure and function. Simulation studies show that FGWAS outperforms existing GWAS methods for searching sparse signals in an extremely large search space, while controlling for the family-wise error rate. We have successfully applied FGWAS to large-scale analysis of data from the Alzheimer's Disease Neuroimaging Initiative for 708 subjects, 30,000 vertices on the left and right hippocampal surfaces, and 501,584 SNPs. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Damage analysis: damage function development and application

    International Nuclear Information System (INIS)

    Simons, R.L.; Odette, G.R.

    1975-01-01

    The derivation and application of damage functions, including recent developments for the U.S. LMFBR and CTR programs, is reviewed. A primary application of damage functions is in predicting component life expectancies; i.e., the fluence required in a service spectrum to attain a specified design property change. An important part of the analysis is the estimation of the uncertainty in such fluence limit predictions. The status of standardizing the procedures for the derivation and application of damage functions is discussed. Improvements in several areas of damage function development are needed before standardization can be completed. These include increasing the quantity and quality of the data used in the analysis, determining the limitations of the analysis due to the presence of multiple damage mechanisms, and finally, testing of damage function predictions against data obtained from material surveillance programs in operating thermal and fast reactors. 23 references. (auth)

  12. Quantum functional analysis non-coordinate approach

    CERN Document Server

    Helemskii, A Ya

    2010-01-01

    This book contains a systematic presentation of quantum functional analysis, a mathematical subject also known as operator space theory. Created in the 1980s, it nowadays is one of the most prominent areas of functional analysis, both as a field of active research and as a source of numerous important applications. The approach taken in this book differs significantly from the standard approach used in studying operator space theory. Instead of viewing "quantized coefficients" as matrices in a fixed basis, in this book they are interpreted as finite rank operators in a fixed Hilbert space. This allows the author to replace matrix computations with algebraic techniques of module theory and tensor products, thus achieving a more invariant approach to the subject. The book can be used by graduate students and research mathematicians interested in functional analysis and related areas of mathematics and mathematical physics. Prerequisites include standard courses in abstract algebra and functional analysis.

  13. Functional Requirement Analysis and Function Allocation for APR 1400

    International Nuclear Information System (INIS)

    Nuraslinda, Anuar; Florah, Kamanja; Noloyiso, Mtoko and others

    2013-01-01

    This paper intends to fulfill the FRA and FA of the HFE as required in Chapter 4 of NUREG-0711 rev. 3 for APR1400 to satisfy both plant safety and power generation objectives. This paper aims to evaluate the FRA and FA for APR1400. The allocation of function is done at the system level for all processes for both the power generation and safety goals, following the NUREG/CR-3331 guideline. As a conclusion, this paper has successfully implemented the requirements and methodology specified in NUREG-0711 for APR 1400. The Functional Requirement Analysis (FRA) and Function Allocation (FA) are required by the regulation in the Human Factors Engineering (HFE) program. The FRA defines the functions, processes, and system for plant safety and power generation. The FA allocates the functions to human operator, automation, or a combination of two. The FRA and FA for APR1400 have been performed in the very early stage of development but only for the plant safety. However, the analysis did not include the goal of power generation and also did not fully satisfy the latest revision of NUREG-0711

  14. Functional analysis of the exploratory studies facility

    International Nuclear Information System (INIS)

    Duffy, M.A.; Mozhi, T.A.; Kumar, P.N.; Senderling, M.S.; Lemeshewsky, W.A.

    1993-01-01

    The 'Physical System Requirements - Exploratory Studies Facility' (PSR-ESF) was developed as part of an improved management structure and procedure initiative by the OCRWM for managing the disposal of spent nuclear fuel and high-level radioactive wastes. This paper discusses the development of the PSR-EF document. Based on a functional analysis approach, this document includes results in the form of boundary diagrams, function hierarchy trees, function description tables containing a compilation of requirements, architecture tree and tables, and functional flow diagrams. The approach used ensures the flowdown and traceability of relevant requirements for the ESF design process

  15. Spectral theory and nonlinear functional analysis

    CERN Document Server

    Lopez-Gomez, Julian

    2001-01-01

    This Research Note addresses several pivotal problems in spectral theory and nonlinear functional analysis in connection with the analysis of the structure of the set of zeroes of a general class of nonlinear operators. It features the construction of an optimal algebraic/analytic invariant for calculating the Leray-Schauder degree, new methods for solving nonlinear equations in Banach spaces, and general properties of components of solutions sets presented with minimal use of topological tools. The author also gives several applications of the abstract theory to reaction diffusion equations and systems.The results presented cover a thirty-year period and include recent, unpublished findings of the author and his coworkers. Appealing to a broad audience, Spectral Theory and Nonlinear Functional Analysis contains many important contributions to linear algebra, linear and nonlinear functional analysis, and topology and opens the door for further advances.

  16. Multilevel sparse functional principal component analysis.

    Science.gov (United States)

    Di, Chongzhi; Crainiceanu, Ciprian M; Jank, Wolfgang S

    2014-01-29

    We consider analysis of sparsely sampled multilevel functional data, where the basic observational unit is a function and data have a natural hierarchy of basic units. An example is when functions are recorded at multiple visits for each subject. Multilevel functional principal component analysis (MFPCA; Di et al. 2009) was proposed for such data when functions are densely recorded. Here we consider the case when functions are sparsely sampled and may contain only a few observations per function. We exploit the multilevel structure of covariance operators and achieve data reduction by principal component decompositions at both between and within subject levels. We address inherent methodological differences in the sparse sampling context to: 1) estimate the covariance operators; 2) estimate the functional principal component scores; 3) predict the underlying curves. Through simulations the proposed method is able to discover dominating modes of variations and reconstruct underlying curves well even in sparse settings. Our approach is illustrated by two applications, the Sleep Heart Health Study and eBay auctions.

  17. SURFACE TEXTURE ANALYSIS FOR FUNCTIONALITY CONTROL

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo; Andreasen, Jan Lasson; Tosello, Guido

    This document is used in connection with three exercises of 3 hours duration as a part of the course VISION ONLINE – One week course on Precision & Nanometrology. The exercises concern surface texture analysis for functionality control, in connection with three different case stories. This docume...... contains a short description of each case story, 3-D roughness parameters analysis and relation with the product’s functionality.......This document is used in connection with three exercises of 3 hours duration as a part of the course VISION ONLINE – One week course on Precision & Nanometrology. The exercises concern surface texture analysis for functionality control, in connection with three different case stories. This document...

  18. Functional data analysis of sleeping energy expenditure.

    Science.gov (United States)

    Lee, Jong Soo; Zakeri, Issa F; Butte, Nancy F

    2017-01-01

    Adequate sleep is crucial during childhood for metabolic health, and physical and cognitive development. Inadequate sleep can disrupt metabolic homeostasis and alter sleeping energy expenditure (SEE). Functional data analysis methods were applied to SEE data to elucidate the population structure of SEE and to discriminate SEE between obese and non-obese children. Minute-by-minute SEE in 109 children, ages 5-18, was measured in room respiration calorimeters. A smoothing spline method was applied to the calorimetric data to extract the true smoothing function for each subject. Functional principal component analysis was used to capture the important modes of variation of the functional data and to identify differences in SEE patterns. Combinations of functional principal component analysis and classifier algorithm were used to classify SEE. Smoothing effectively removed instrumentation noise inherent in the room calorimeter data, providing more accurate data for analysis of the dynamics of SEE. SEE exhibited declining but subtly undulating patterns throughout the night. Mean SEE was markedly higher in obese than non-obese children, as expected due to their greater body mass. SEE was higher among the obese than non-obese children (p0.1, after post hoc testing). Functional principal component scores for the first two components explained 77.8% of the variance in SEE and also differed between groups (p = 0.037). Logistic regression, support vector machine or random forest classification methods were able to distinguish weight-adjusted SEE between obese and non-obese participants with good classification rates (62-64%). Our results implicate other factors, yet to be uncovered, that affect the weight-adjusted SEE of obese and non-obese children. Functional data analysis revealed differences in the structure of SEE between obese and non-obese children that may contribute to disruption of metabolic homeostasis.

  19. Theoretical analysis of polarized structure functions

    International Nuclear Information System (INIS)

    Altarelli, G.; ); Ball, R.D.; Forte, S.; Ridolfi, G.

    1998-01-01

    We review the analysis of polarized structure function data using perturbative QCD and NLO We use the most recent experimental data to obtain updated results for polarized parton distributions, first moments and the strong coupling. We also discuss several theoretical issues involving in this analysis and in the interpretation of its results. Finally, we compare our results with other similar analyses in the recent literature. (author)

  20. Theoretical Analysis of Polarized Structure Functions

    CERN Document Server

    Altarelli, Guido; Forte, Stefano; Ridolfi, G

    1998-01-01

    We review the analysis of polarized structure function data using perturbative QCD at next-to-leading order. We use the most recent experimental data to obtain updated results for polarized parton distributions, first moments and the strong coupling. We also discuss several theoretical issues involved in this analysis and in the interpretation of its results. Finally, we compare our results with other similar analyses in the recent literature.

  1. Reliability analysis of software based safety functions

    International Nuclear Information System (INIS)

    Pulkkinen, U.

    1993-05-01

    The methods applicable in the reliability analysis of software based safety functions are described in the report. Although the safety functions also include other components, the main emphasis in the report is on the reliability analysis of software. The check list type qualitative reliability analysis methods, such as failure mode and effects analysis (FMEA), are described, as well as the software fault tree analysis. The safety analysis based on the Petri nets is discussed. The most essential concepts and models of quantitative software reliability analysis are described. The most common software metrics and their combined use with software reliability models are discussed. The application of software reliability models in PSA is evaluated; it is observed that the recent software reliability models do not produce the estimates needed in PSA directly. As a result from the study some recommendations and conclusions are drawn. The need of formal methods in the analysis and development of software based systems, the applicability of qualitative reliability engineering methods in connection to PSA and the need to make more precise the requirements for software based systems and their analyses in the regulatory guides should be mentioned. (orig.). (46 refs., 13 figs., 1 tab.)

  2. Adaptive Analysis of Functional MRI Data

    International Nuclear Information System (INIS)

    Friman, Ola

    2003-01-01

    Functional Magnetic Resonance Imaging (fMRI) is a recently developed neuro-imaging technique with capacity to map neural activity with high spatial precision. To locate active brain areas, the method utilizes local blood oxygenation changes which are reflected as small intensity changes in a special type of MR images. The ability to non-invasively map brain functions provides new opportunities to unravel the mysteries and advance the understanding of the human brain, as well as to perform pre-surgical examinations in order to optimize surgical interventions. This dissertation introduces new approaches for the analysis of fMRI data. The detection of active brain areas is a challenging problem due to high noise levels and artifacts present in the data. A fundamental tool in the developed methods is Canonical Correlation Analysis (CCA). CCA is used in two novel ways. First as a method with the ability to fully exploit the spatio-temporal nature of fMRI data for detecting active brain areas. Established analysis approaches mainly focus on the temporal dimension of the data and they are for this reason commonly referred to as being mass-univariate. The new CCA detection method encompasses and generalizes the traditional mass-univariate methods and can in this terminology be viewed as a mass-multivariate approach. The concept of spatial basis functions is introduced as a spatial counterpart of the temporal basis functions already in use in fMRI analysis. The spatial basis functions implicitly perform an adaptive spatial filtering of the fMRI images, which significantly improves detection performance. It is also shown how prior information can be incorporated into the analysis by imposing constraints on the temporal and spatial models and a constrained version of CCA is devised to this end. A general Principal Component Analysis technique for generating and constraining temporal and spatial subspace models is proposed to be used in combination with the constrained CCA

  3. Functional data analysis of sleeping energy expenditure

    Science.gov (United States)

    Adequate sleep is crucial during childhood for metabolic health, and physical and cognitive development. Inadequate sleep can disrupt metabolic homeostasis and alter sleeping energy expenditure (SEE). Functional data analysis methods were applied to SEE data to elucidate the population structure of ...

  4. Chemical kinetic functional sensitivity analysis: Elementary sensitivities

    International Nuclear Information System (INIS)

    Demiralp, M.; Rabitz, H.

    1981-01-01

    Sensitivity analysis is considered for kinetics problems defined in the space--time domain. This extends an earlier temporal Green's function method to handle calculations of elementary functional sensitivities deltau/sub i//deltaα/sub j/ where u/sub i/ is the ith species concentration and α/sub j/ is the jth system parameter. The system parameters include rate constants, diffusion coefficients, initial conditions, boundary conditions, or any other well-defined variables in the kinetic equations. These parameters are generally considered to be functions of position and/or time. Derivation of the governing equations for the sensitivities and the Green's funciton are presented. The physical interpretation of the Green's function and sensitivities is given along with a discussion of the relation of this work to earlier research

  5. Hand function evaluation: a factor analysis study.

    Science.gov (United States)

    Jarus, T; Poremba, R

    1993-05-01

    The purpose of this study was to investigate hand function evaluations. Factor analysis with varimax rotation was used to assess the fundamental characteristics of the items included in the Jebsen Hand Function Test and the Smith Hand Function Evaluation. The study sample consisted of 144 subjects without disabilities and 22 subjects with Colles fracture. Results suggest a four factor solution: Factor I--pinch movement; Factor II--grasp; Factor III--target accuracy; and Factor IV--activities of daily living. These categories differentiated the subjects without Colles fracture from the subjects with Colles fracture. A hand function evaluation consisting of these four factors would be useful. Such an evaluation that can be used for current clinical purposes is provided.

  6. First Meeting in Topology and Functional Analysis

    CERN Document Server

    López-Pellicer, Manuel

    2014-01-01

    Descriptive topology and functional analysis, with extensive material demonstrating new connections between them, are the subject of the first section of this work. Applications to spaces of continuous functions, topological Abelian groups, linear topological equivalence and to the separable quotient problem are included and are presented as open problems. The second section is devoted to Banach spaces, Banach algebras and operator theory. Each chapter presents a lot of worthwhile and important recent theorems with an abstract discussing the material in the chapter. Each chapter can almost be seen as a survey covering a particular area.

  7. Function analysis of steam isolation valves

    International Nuclear Information System (INIS)

    Persson, R.; Kilpi, K.; Noro, H.; Siikonen, T.; Sjoeberg, A.; Wallen, G.; Aakesson, H.

    1981-01-01

    Function analysis of system-medium-operated steam isolation valves has been the objective of the Swedish-Finnish IVLS project, the results of which are presented in this report. Theoretical models were to be verified against available experimental data, to some extent from the HDR blowdown experiments, which are part of a German reactor safety program. Finnish hydraulic measurements on a valve model (scale 1:2.15) have been performed to give complementary data. The analysis work has covered the thermal-hydraulic behaviour of steam isolation valves as well as phenomena related to structural mechanics. Work performed under contract with the Swedish Nuclear Power Inspectorate. (Author)

  8. Function analysis of steam isolation valves

    International Nuclear Information System (INIS)

    Persson, R.; Sjoeberg, A.; Aakesson, H.; Kilpi, K.; Noro, H.; Siikonen, T.; Wallen, G.

    1981-01-01

    Function analysis of system-medium-operated steam isolation valves has been the objective of the Swedish-Finnish IVLS project, the results of which are presented in this report. Theoretical models were to be verified against available experimental data, to some extent from the HDR blowdown experiments, which are part of a German reactor safety program. Finnish hydraulic measurements on a valve model (scale 1:2.15) have been performed to give complementary data. The analysis work has covered the thermal-hydraulic behaviour of steam isolation valves as well as phenomena related to structural mechanics. (Auth.)

  9. Fracture Analysis of Functionally Graded Materials

    International Nuclear Information System (INIS)

    Zhang, Ch.; Gao, X. W.; Sladek, J.; Sladek, V.

    2010-01-01

    This paper reports our recent research works on crack analysis in continuously non-homogeneous and linear elastic functionally graded materials. A meshless boundary element method is developed for this purpose. Numerical examples are presented and discussed to demonstrate the efficiency and the accuracy of the present numerical method, and to show the effects of the material gradation on the crack-opening-displacements and the stress intensity factors.

  10. Survival Function Analysis of Planet Size Distribution

    OpenAIRE

    Zeng, Li; Jacobsen, Stein B.; Sasselov, Dimitar D.; Vanderburg, Andrew

    2018-01-01

    Applying the survival function analysis to the planet radius distribution of the Kepler exoplanet candidates, we have identified two natural divisions of planet radius at 4 Earth radii and 10 Earth radii. These divisions place constraints on planet formation and interior structure model. The division at 4 Earth radii separates small exoplanets from large exoplanets above. When combined with the recently-discovered radius gap at 2 Earth radii, it supports the treatment of planets 2-4 Earth rad...

  11. Industrial entrepreneurial network: Structural and functional analysis

    Science.gov (United States)

    Medvedeva, M. A.; Davletbaev, R. H.; Berg, D. B.; Nazarova, J. J.; Parusheva, S. S.

    2016-12-01

    Structure and functioning of two model industrial entrepreneurial networks are investigated in the present paper. One of these networks is forming when implementing an integrated project and consists of eight agents, which interact with each other and external environment. The other one is obtained from the municipal economy and is based on the set of the 12 real business entities. Analysis of the networks is carried out on the basis of the matrix of mutual payments aggregated over the certain time period. The matrix is created by the methods of experimental economics. Social Network Analysis (SNA) methods and instruments were used in the present research. The set of basic structural characteristics was investigated: set of quantitative parameters such as density, diameter, clustering coefficient, different kinds of centrality, and etc. They were compared with the random Bernoulli graphs of the corresponding size and density. Discovered variations of random and entrepreneurial networks structure are explained by the peculiarities of agents functioning in production network. Separately, were identified the closed exchange circuits (cyclically closed contours of graph) forming an autopoietic (self-replicating) network pattern. The purpose of the functional analysis was to identify the contribution of the autopoietic network pattern in its gross product. It was found that the magnitude of this contribution is more than 20%. Such value allows using of the complementary currency in order to stimulate economic activity of network agents.

  12. 308 Building deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describes what needs to be performed to deactivate the 308 Building

  13. PUREX Plant deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate PUREX

  14. 309 Building deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate the 309 Building

  15. FFTF Plant transition function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and function hierarchy charts that describe what needs to be performed to deactivate FFTF

  16. FANTOM: Functional and taxonomic analysis of metagenomes

    Directory of Open Access Journals (Sweden)

    Sanli Kemal

    2013-02-01

    Full Text Available Abstract Background Interpretation of quantitative metagenomics data is important for our understanding of ecosystem functioning and assessing differences between various environmental samples. There is a need for an easy to use tool to explore the often complex metagenomics data in taxonomic and functional context. Results Here we introduce FANTOM, a tool that allows for exploratory and comparative analysis of metagenomics abundance data integrated with metadata information and biological databases. Importantly, FANTOM can make use of any hierarchical database and it comes supplied with NCBI taxonomic hierarchies as well as KEGG Orthology, COG, PFAM and TIGRFAM databases. Conclusions The software is implemented in Python, is platform independent, and is available at http://www.sysbio.se/Fantom.

  17. Functional Data Analysis Applied in Chemometrics

    DEFF Research Database (Denmark)

    Muller, Martha

    nutritional status and metabolic phenotype. We want to understand how metabolomic spectra can be analysed using functional data analysis to detect the in uence of dierent factors on specic metabolites. These factors can include, for example, gender, diet culture or dietary intervention. In Paper I we apply...... representation of each spectrum. Subset selection of wavelet coecients generates the input to mixed models. Mixed-model methodology enables us to take the study design into account while modelling covariates. Bootstrap-based inference preserves the correlation structure between curves and enables the estimation...

  18. A Complexity Analysis of Functional Interpretations

    DEFF Research Database (Denmark)

    Hernest, Mircea-Dan; Kohlenbach, Ulrich

    2003-01-01

    We give a quantitative analysis of G ̈odel’s functional interpretation and its monotone variant. The two have been used for the extraction of programs and numerical bounds as well as for conservation results. They apply both to (semi-)intuitionistic as well as (combined with negative translation...... of the verifying proof. In all cases terms of size linear in the size of the proof at input can be extracted and the corresponding extraction algorithms have cubic worst-time complexity. The verifying proofs have depth linear in the depth of the proof at input and the maximal size of a formula of this proof....

  19. A complexity analysis of functional interpretations

    DEFF Research Database (Denmark)

    Hernest, Mircea-Dan; Kohlenbach, Ulrich

    2005-01-01

    Summary: We give a quantitative analysis of Gödel's functional     interpretation and its monotone variant. The two have been used     for the extraction of programs and numerical bounds as well as     for conservation results. They apply both to (semi-)intuitionistic     as well as (combined...... with negative translation) classical proofs.     The proofs may be formalized in systems ranging from weak base     systems to arithmetic and analysis (and numerous fragments of     these). We give upper bounds in basic proof data on the depth,     size, maximal type degree and maximal type arity...

  20. Biosignals Analysis for Kidney Function Effect Analysis of Fennel Aromatherapy

    Science.gov (United States)

    Kim, Bong-Hyun; Cho, Dong-Uk; Seo, Ssang-Hee

    2015-01-01

    Human effort in order to enjoy a healthy life is diverse. IT technology to these analyzes, the results of development efforts, it has been applied. Therefore, I use the care and maintenance diagnostic health management and prevention than treatment. In particular, the aromatherapy treatment easy to use without the side effects there is no irritation, are widely used in modern society. In this paper, we measured the aroma effect by applying a biosignal analysis techniques; an experiment was performed to analyze. In particular, we design methods and processes of research based on the theory aroma that affect renal function. Therefore, in this paper, measuring the biosignals and after fennel aromatherapy treatment prior to the enforcement of the mutual comparison, through the analysis, studies were carried out to analyze the effect of fennel aromatherapy therapy on kidney function. PMID:25977696

  1. Creep analysis by the path function method

    International Nuclear Information System (INIS)

    Akin, J.E.; Pardue, R.M.

    1977-01-01

    The finite element method has become a common analysis procedure for the creep analysis of structures. The most recent programs are designed to handle a general class of material properties and are able to calculate elastic, plastic, and creep components of strain under general loading histories. The constant stress approach is too crude a model to accurately represent the actual behaviour of the stress for large time steps. The true path of a point in the effective stress-effective strain (sigmasup(e)-epsilonsup(c)) plane is often one in which the slope is rapidly changing. Thus the stress level quickly moves away from the initial stress level and then gradually approaches the final one. The result is that the assumed constant stress level quickly becomes inaccurate. What is required is a better method of approximation of the true path in the sigmasup(e)-epsilonsup(c) space. The method described here is called the path function approach because it employs an assumed function to estimate the motion of points in the sigmasup(e)-epsilonsup(c) space. (Auth.)

  2. Problems in real and functional analysis

    CERN Document Server

    Torchinsky, Alberto

    2015-01-01

    It is generally believed that solving problems is the most important part of the learning process in mathematics because it forces students to truly understand the definitions, comb through the theorems and proofs, and think at length about the mathematics. The purpose of this book is to complement the existing literature in introductory real and functional analysis at the graduate level with a variety of conceptual problems (1,457 in total), ranging from easily accessible to thought provoking, mixing the practical and the theoretical aspects of the subject. Problems are grouped into ten chapters covering the main topics usually taught in courses on real and functional analysis. Each of these chapters opens with a brief reader's guide stating the needed definitions and basic results in the area and closes with a short description of the problems. The Problem chapters are accompanied by Solution chapters, which include solutions to two-thirds of the problems. Students can expect the solutions to be written in ...

  3. Functional data analysis of generalized regression quantiles

    KAUST Repository

    Guo, Mengmeng

    2013-11-05

    Generalized regression quantiles, including the conditional quantiles and expectiles as special cases, are useful alternatives to the conditional means for characterizing a conditional distribution, especially when the interest lies in the tails. We develop a functional data analysis approach to jointly estimate a family of generalized regression quantiles. Our approach assumes that the generalized regression quantiles share some common features that can be summarized by a small number of principal component functions. The principal component functions are modeled as splines and are estimated by minimizing a penalized asymmetric loss measure. An iterative least asymmetrically weighted squares algorithm is developed for computation. While separate estimation of individual generalized regression quantiles usually suffers from large variability due to lack of sufficient data, by borrowing strength across data sets, our joint estimation approach significantly improves the estimation efficiency, which is demonstrated in a simulation study. The proposed method is applied to data from 159 weather stations in China to obtain the generalized quantile curves of the volatility of the temperature at these stations. © 2013 Springer Science+Business Media New York.

  4. Functional data analysis of generalized regression quantiles

    KAUST Repository

    Guo, Mengmeng; Zhou, Lan; Huang, Jianhua Z.; Hä rdle, Wolfgang Karl

    2013-01-01

    Generalized regression quantiles, including the conditional quantiles and expectiles as special cases, are useful alternatives to the conditional means for characterizing a conditional distribution, especially when the interest lies in the tails. We develop a functional data analysis approach to jointly estimate a family of generalized regression quantiles. Our approach assumes that the generalized regression quantiles share some common features that can be summarized by a small number of principal component functions. The principal component functions are modeled as splines and are estimated by minimizing a penalized asymmetric loss measure. An iterative least asymmetrically weighted squares algorithm is developed for computation. While separate estimation of individual generalized regression quantiles usually suffers from large variability due to lack of sufficient data, by borrowing strength across data sets, our joint estimation approach significantly improves the estimation efficiency, which is demonstrated in a simulation study. The proposed method is applied to data from 159 weather stations in China to obtain the generalized quantile curves of the volatility of the temperature at these stations. © 2013 Springer Science+Business Media New York.

  5. Imaging of brain function based on the analysis of functional ...

    African Journals Online (AJOL)

    Objective: This Study observed the relevant brain areas activated by acupuncture at the Taichong acupoint (LR3) and analyzed the functional connectivity among brain areas using resting state functional magnetic resonance imaging (fMRI) to explore the acupoint specificity of the Taichong acupoint. Methods: A total of 45 ...

  6. Human milk metagenome: a functional capacity analysis

    Science.gov (United States)

    2013-01-01

    Background Human milk contains a diverse population of bacteria that likely influences colonization of the infant gastrointestinal tract. Recent studies, however, have been limited to characterization of this microbial community by 16S rRNA analysis. In the present study, a metagenomic approach using Illumina sequencing of a pooled milk sample (ten donors) was employed to determine the genera of bacteria and the types of bacterial open reading frames in human milk that may influence bacterial establishment and stability in this primal food matrix. The human milk metagenome was also compared to that of breast-fed and formula-fed infants’ feces (n = 5, each) and mothers’ feces (n = 3) at the phylum level and at a functional level using open reading frame abundance. Additionally, immune-modulatory bacterial-DNA motifs were also searched for within human milk. Results The bacterial community in human milk contained over 360 prokaryotic genera, with sequences aligning predominantly to the phyla of Proteobacteria (65%) and Firmicutes (34%), and the genera of Pseudomonas (61.1%), Staphylococcus (33.4%) and Streptococcus (0.5%). From assembled human milk-derived contigs, 30,128 open reading frames were annotated and assigned to functional categories. When compared to the metagenome of infants’ and mothers’ feces, the human milk metagenome was less diverse at the phylum level, and contained more open reading frames associated with nitrogen metabolism, membrane transport and stress response (P milk metagenome also contained a similar occurrence of immune-modulatory DNA motifs to that of infants’ and mothers’ fecal metagenomes. Conclusions Our results further expand the complexity of the human milk metagenome and enforce the benefits of human milk ingestion on the microbial colonization of the infant gut and immunity. Discovery of immune-modulatory motifs in the metagenome of human milk indicates more exhaustive analyses of the functionality of the human

  7. Correspondence between Traditional Models of Functional Analysis and a Functional Analysis of Manding Behavior

    Science.gov (United States)

    LaRue, Robert H.; Sloman, Kimberly N.; Weiss, Mary Jane; Delmolino, Lara; Hansford, Amy; Szalony, Jill; Madigan, Ryan; Lambright, Nathan M.

    2011-01-01

    Functional analysis procedures have been effectively used to determine the maintaining variables for challenging behavior and subsequently develop effective interventions. However, fear of evoking dangerous topographies of maladaptive behavior and concerns for reinforcing infrequent maladaptive behavior present challenges for people working in…

  8. Microscopic theory of the superconducting gap in the quasi-one-dimensional organic conductor (TMTSF) 2ClO4 : Model derivation and two-particle self-consistent analysis

    Science.gov (United States)

    Aizawa, Hirohito; Kuroki, Kazuhiko

    2018-03-01

    We present a first-principles band calculation for the quasi-one-dimensional (Q1D) organic superconductor (TMTSF) 2ClO4 . An effective tight-binding model with the TMTSF molecule to be regarded as the site is derived from a calculation based on maximally localized Wannier orbitals. We apply a two-particle self-consistent (TPSC) analysis by using a four-site Hubbard model, which is composed of the tight-binding model and an onsite (intramolecular) repulsive interaction, which serves as a variable parameter. We assume that the pairing mechanism is mediated by the spin fluctuation, and the sign of the superconducting gap changes between the inner and outer Fermi surfaces, which correspond to a d -wave gap function in a simplified Q1D model. With the parameters we adopt, the critical temperature for superconductivity estimated by the TPSC approach is approximately 1 K, which is consistent with experiment.

  9. Development of pair distribution function analysis

    International Nuclear Information System (INIS)

    Vondreele, R.; Billinge, S.; Kwei, G.; Lawson, A.

    1996-01-01

    This is the final report of a 3-year LDRD project at LANL. It has become more and more evident that structural coherence in the CuO 2 planes of high-T c superconducting materials over some intermediate length scale (nm range) is important to superconductivity. In recent years, the pair distribution function (PDF) analysis of powder diffraction data has been developed for extracting structural information on these length scales. This project sought to expand and develop this technique, use it to analyze neutron powder diffraction data, and apply it to problems. In particular, interest is in the area of high-T c superconductors, although we planned to extend the study to the closely related perovskite ferroelectric materials andother materials where the local structure affects the properties where detailed knowledge of the local and intermediate range structure is important. In addition, we planned to carry out single crystal experiments to look for diffuse scattering. This information augments the information from the PDF

  10. Introducing trimming and function ranking to Solid Works based on function analysis

    NARCIS (Netherlands)

    Chechurin, Leonid S.; Wits, Wessel Willems; Bakker, Hans M.; Cascini, G.; Vaneker, Thomas H.J.

    2011-01-01

    TRIZ based Function Analysis models existing products based on functional interactions between product parts. Such a function model description is the ideal starting point for product innovation. Design engineers can apply (TRIZ) methods such as trimming and function ranking to this function model

  11. Introducing Trimming and Function Ranking to SolidWorks based on Function Analysis

    NARCIS (Netherlands)

    Chechurin, L.S.; Wits, Wessel Willems; Bakker, Hans M.; Vaneker, Thomas H.J.

    2015-01-01

    TRIZ based Function Analysis models existing products based on functional interactions between product parts. Such a function model description is the ideal starting point for product innovation. Design engineers can apply (TRIZ) methods such as trimming and function ranking to this function model

  12. Analysis of Discrete Mittag - Leffler Functions

    Directory of Open Access Journals (Sweden)

    N. Shobanadevi

    2015-03-01

    Full Text Available Discrete Mittag - Leffler functions play a major role in the development of the theory of discrete fractional calculus. In the present article, we analyze qualitative properties of discrete Mittag - Leffler functions and establish sufficient conditions for convergence, oscillation and summability of the infinite series associated with discrete Mittag - Leffler functions.

  13. Monogenic functions with parameters in Clifford analysis

    International Nuclear Information System (INIS)

    Le Hung Son.

    1990-02-01

    In this paper we study some properties of monogenic functions taking values in a Clifford algebra and depending on several parameters. It is proved that the Hartogs extension theorems are valid for these functions and for the multi-monogenic functions, which contain solutions of many important systems of partial differential equations in Theoretical Physics. (author). 4 refs

  14. Contracting Out Government Procurement Functions: An Analysis

    National Research Council Canada - National Science Library

    Lamm, David; Yoder, Cory

    2008-01-01

    ...)), asked the Naval Postgraduate School (NPS) to analyze the contracting out of procurement functions currently being accomplished by Navy, Marine Corps, and other Department of Defense (DOD) Activities...

  15. Functional analysis of systems for the project AP-600

    International Nuclear Information System (INIS)

    Fernandez, L.A.; Lopez, A.; Gayo, C.; Garcia, A.

    1993-01-01

    A methodology to carry out functional analysis of AP-600 is given. This analysis allows to optimize the Control Room design. The final result of the functional analysis will be: 1) set of date recording formats conveniently fulfilled will ensure coherent information. 2) A functional structure where tasks associated to the different functional the system are represented. 3) An analysis of tasks where all data necessary to perform a task will be identified. With this analysis it is guaranteed that all operator necessities and machine demands are contemplated and coordinated by control room design. 4) Allocation of tasks man/machine which allows an optimum and safe plant exploitation

  16. A Didactic Analysis of Functional Queues

    Science.gov (United States)

    Rinderknecht, Christian

    2011-01-01

    When first introduced to the analysis of algorithms, students are taught how to assess the best and worst cases, whereas the mean and amortized costs are considered advanced topics, usually saved for graduates. When presenting the latter, aggregate analysis is explained first because it is the most intuitive kind of amortized analysis, often…

  17. Functional analysis for complex systems of nuclear fusion plant

    International Nuclear Information System (INIS)

    Pinna, Tonio; Dongiovanni, Danilo Nicola; Iannone, Francesco

    2016-01-01

    Highlights: • Functional analysis for complex systems. • Functional Flow Block Diagrams (FFBD). • IDEFØ diagrams. • Petri Net algorithm - Abstract: In system engineering context, a functional analysis is the systematic process of identifying, describing and correlating the functions a system must perform in order to be successful at any foreseen life-cycle phase or operational state/mode. By focusing on what the system must do disregarding the implementation, the functional analysis supports an unbiased system requirement allocation analysis. The system function architecture is defined in terms of process, protection (interlock) or nuclear safety functions. Then, the system functions are analyzed from several points of view in order to highlight the various pieces of information defining the way the system is designed to accomplish its mission as defined in the system requirement documents. The process functional flow is identified and represented by Functional Flow Block Diagrams (FFBD) while the system function interfaces are identified and represented by IDEFØ diagrams. Function interfaces are defined as relationships across identified functions in terms of function input (from other functions or requirements), output (added value or outcome of the function), controls (from other functions or systems) and mechanisms necessary to fulfill the function. The function architecture is further detailed by considering for each function: a) the phase of application, b) the actions performed c) the controlled variable and control actions to be foreseen in the implementation of the functions, d) the system involved in the control action, e) the equipment involved in the function, f) the requirements allocated to the function. The methodology here presented are suggested for the designing of fusion facilities and reactors already from the first phases of the pre-conceptual design, as it is now for DEMO.

  18. Genomic analysis of Xenopus organizer function

    Directory of Open Access Journals (Sweden)

    Suhai Sándor

    2006-06-01

    Full Text Available Abstract Background Studies of the Xenopus organizer have laid the foundation for our understanding of the conserved signaling pathways that pattern vertebrate embryos during gastrulation. The two primary activities of the organizer, BMP and Wnt inhibition, can regulate a spectrum of genes that pattern essentially all aspects of the embryo during gastrulation. As our knowledge of organizer signaling grows, it is imperative that we begin knitting together our gene-level knowledge into genome-level signaling models. The goal of this paper was to identify complete lists of genes regulated by different aspects of organizer signaling, thereby providing a deeper understanding of the genomic mechanisms that underlie these complex and fundamental signaling events. Results To this end, we ectopically overexpress Noggin and Dkk-1, inhibitors of the BMP and Wnt pathways, respectively, within ventral tissues. After isolating embryonic ventral halves at early and late gastrulation, we analyze the transcriptional response to these molecules within the generated ectopic organizers using oligonucleotide microarrays. An efficient statistical analysis scheme, combined with a new Gene Ontology biological process annotation of the Xenopus genome, allows reliable and faithful clustering of molecules based upon their roles during gastrulation. From this data, we identify new organizer-related expression patterns for 19 genes. Moreover, our data sub-divides organizer genes into separate head and trunk organizing groups, which each show distinct responses to Noggin and Dkk-1 activity during gastrulation. Conclusion Our data provides a genomic view of the cohorts of genes that respond to Noggin and Dkk-1 activity, allowing us to separate the role of each in organizer function. These patterns demonstrate a model where BMP inhibition plays a largely inductive role during early developmental stages, thereby initiating the suites of genes needed to pattern dorsal tissues

  19. Shape Analysis Using the Auto Diffusion Function

    DEFF Research Database (Denmark)

    Gebal, Katarzyna; Bærentzen, Jakob Andreas; Aanæs, Henrik

    2009-01-01

    Scalar functions defined on manifold triangle meshes is a starting point for many geometry processing algorithms such as mesh parametrization, skeletonization, and segmentation. In this paper, we propose the Auto Diffusion Function (ADF) which is a linear combination of the eigenfunctions......, it is controlled by a single parameter which can be interpreted as feature scale, and, finally, the ADF is invariant to rigid and isometric deformations. We describe the ADF and its properties in detail and compare it to other choices of scalar functions on manifolds. As an example of an application, we present...

  20. Trial-Based Functional Analysis and Functional Communication Training in an Early Childhood Setting

    Science.gov (United States)

    Lambert, Joseph M.; Bloom, Sarah E.; Irvin, Jennifer

    2012-01-01

    Problem behavior is common in early childhood special education classrooms. Functional communication training (FCT; Carr & Durand, 1985) may reduce problem behavior but requires identification of its function. The trial-based functional analysis (FA) is a method that can be used to identify problem behavior function in schools. We conducted…

  1. Crystal field parameters with Wannier functions: application to Nd.sub.2./sub.Fe.sub.14./sub.B systems

    Czech Academy of Sciences Publication Activity Database

    Yoshioka, T.; Tsuchiura, H.; Novák, Pavel

    2015-01-01

    Roč. 19, Sup.3 (2015), S4-S8 ISSN 1432-8917 Institutional support: RVO:68378271 Keywords : crystal field parameters * Nd-Fe-B permanent magnet Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.830, year: 2014

  2. Functional Enhancements in Used Oil Analysis Spectrometers

    National Research Council Canada - National Science Library

    Lukas, Malte

    1998-01-01

    Spark emission spectrometers using the rotating disk electrode (RDE) technique have become the workhorses and primary analytical tool of most machine condition monitoring programs based on oil analysis...

  3. Descriptive Topology in Selected Topics of Functional Analysis

    CERN Document Server

    Kakol, J; Pellicer, Manuel Lopez

    2011-01-01

    "Descriptive Topology in Selected Topics of Functional Analysis" is a collection of recent developments in the field of descriptive topology, specifically focused on the classes of infinite-dimensional topological vector spaces that appear in functional analysis. Such spaces include Frechet spaces, (LF)-spaces and their duals, and the space of continuous real-valued functions C(X) on a completely regular Hausdorff space X, to name a few. These vector spaces appear in functional analysis in distribution theory, differential equations, complex analysis, and various other analytical set

  4. Time-frequency analysis and harmonic Gaussian functions

    International Nuclear Information System (INIS)

    Ranaivoson, R.T.R; Raoelina Andriambololona; Hanitriarivo, R.

    2013-01-01

    A method for time-frequency analysis is given. The approach utilizes properties of Gaussian distribution, properties of Hermite polynomials and Fourier analysis. We begin by the definitions of a set of functions called Harmonic Gaussian Functions. Then these functions are used to define a set of transformations, noted Τ n , which associate to a function ψ, of the time variable t, a set of functions Ψ n which depend on time, frequency and frequency (or time) standard deviation. Some properties of the transformations Τ n and the functions Ψ n are given. It is proved in particular that the square of the modulus of each function Ψ n can be interpreted as a representation of the energy distribution of the signal, represented by the function ψ, in the time-frequency plane for a given value of the frequency (or time) standard deviation. It is also shown that the function ψ can be recovered from the functions Ψ n .

  5. Safety analysis of autonomous excavator functionality

    International Nuclear Information System (INIS)

    Seward, D.; Pace, C.; Morrey, R.; Sommerville, I.

    2000-01-01

    This paper presents an account of carrying out a hazard analysis to define the safety requirements for an autonomous robotic excavator. The work is also relevant to the growing generic class of heavy automated mobile machinery. An overview of the excavator design is provided and the concept of a safety manager is introduced. The safety manager is an autonomous module responsible for all aspects of system operational safety, and is central to the control system's architecture. Each stage of the hazard analysis is described, i.e. system model creation, hazard definition and hazard analysis. Analysis at an early stage of the design process, and on a system that interfaces directly to an unstructured environment, exposes certain issues relevant to the application of current hazard analysis methods. The approach taken in the analysis is described. Finally, it is explained how the results of the hazard analysis have influenced system design, in particular, safety manager specifications. Conclusions are then drawn about the applicability of hazard analysis of requirements in general, and suggestions are made as to how the approach can be taken further

  6. Functional Analysis of P4-ATPases

    DEFF Research Database (Denmark)

    Theorin, Lisa

    and mammalian P4-ATPases have been studied extensively and the physiological function is mostly known, while the exact biochemistry and specific activity is mostly unknown. Even though the plant Arabidopsis thaliana has 12 P4-ATPases, not much is known about their function. In this study, the biochemical...... for purification of the complex by one-step purification. The ATPase activity of the ALA2/ALIS5 complex was stimulated in a highly specific manner by phosphatidylserine. Changes in the phosphatidylserine headgroup or alteration of the stereochemistry affected enzymatic activity. The results demonstrate that ALA2...... is specific for phosphatidylserine and that binding of the lipid to the substrate binding site requires a unique spatial configuration of the lipid head group. Detailed information on the substrate requirements lead the way towards the full function and transport pathway of lipid flippases in plants. Recent...

  7. Functional analysis screening for multiple topographies of problem behavior.

    Science.gov (United States)

    Bell, Marlesha C; Fahmie, Tara A

    2018-04-23

    The current study evaluated a screening procedure for multiple topographies of problem behavior in the context of an ongoing functional analysis. Experimenters analyzed the function of a topography of primary concern while collecting data on topographies of secondary concern. We used visual analysis to predict the function of secondary topographies and a subsequent functional analysis to test those predictions. Results showed that a general function was accurately predicted for five of six (83%) secondary topographies. A specific function was predicted and supported for a subset of these topographies. The experimenters discuss the implication of these results for clinicians who have limited time for functional assessment. © 2018 Society for the Experimental Analysis of Behavior.

  8. Application of functional analysis techniques to supervisory systems

    International Nuclear Information System (INIS)

    Lambert, Manuel; Riera, Bernard; Martel, Gregory

    1999-01-01

    The aim of this paper is to apply firstly two interesting functional analysis techniques for the design of supervisory systems for complex processes, and secondly to discuss the strength and the weaknesses of each of them. Two functional analysis techniques have been applied, SADT (Structured Analysis and Design Technique) and FAST (Functional Analysis System Technique) on a process, an example of a Water Supply Process Control (WSPC) system. These techniques allow a functional description of industrial processes. The paper briefly discusses the functions of a supervisory system and some advantages of the application of functional analysis for the design of a 'human' centered supervisory system. Then the basic principles of the two techniques applied on the WSPC system are presented. Finally, the different results obtained from the two techniques are discussed

  9. Stability analysis of impulsive functional differential equations

    CERN Document Server

    Stamova, Ivanka

    2009-01-01

    This book is devoted to impulsive functional differential equations which are a natural generalization of impulsive ordinary differential equations (without delay) and of functional differential equations (without impulses). At the present time the qualitative theory of such equationsis under rapid development. After a presentation of the fundamental theory of existence, uniqueness and continuability of solutions, a systematic development of stability theory for that class of problems is given which makes the book unique. It addresses to a wide audience such as mathematicians, applied research

  10. Asymptotic analysis for functional stochastic differential equations

    CERN Document Server

    Bao, Jianhai; Yuan, Chenggui

    2016-01-01

    This brief treats dynamical systems that involve delays and random disturbances. The study is motivated by a wide variety of systems in real life in which random noise has to be taken into consideration and the effect of delays cannot be ignored. Concentrating on such systems that are described by functional stochastic differential equations, this work focuses on the study of large time behavior, in particular, ergodicity. This brief is written for probabilists, applied mathematicians, engineers, and scientists who need to use delay systems and functional stochastic differential equations in their work. Selected topics from the brief can also be used in a graduate level topics course in probability and stochastic processes.

  11. An advanced complex analysis problem book topological vector spaces, functional analysis, and Hilbert spaces of analytic functions

    CERN Document Server

    Alpay, Daniel

    2015-01-01

    This is an exercises book at the beginning graduate level, whose aim is to illustrate some of the connections between functional analysis and the theory of functions of one variable. A key role is played by the notions of positive definite kernel and of reproducing kernel Hilbert space. A number of facts from functional analysis and topological vector spaces are surveyed. Then, various Hilbert spaces of analytic functions are studied.

  12. Differential analysis of matrix convex functions

    DEFF Research Database (Denmark)

    Hansen, Frank; Tomiyama, Jun

    2007-01-01

    We analyze matrix convex functions of a fixed order defined in a real interval by differential methods as opposed to the characterization in terms of divided differences given by Kraus [F. Kraus, Über konvekse Matrixfunktionen, Math. Z. 41 (1936) 18-42]. We obtain for each order conditions for ma...

  13. Analysis of the Bogoliubov free energy functional

    DEFF Research Database (Denmark)

    Reuvers, Robin

    In this thesis, we analyse a variational reformulation of the Bogoliubov approximation that is used to describe weakly-interacting translationally-invariant Bose gases. For the resulting model, the `Bogoliubov free energy functional', we demonstrate existence of minimizers as well as the presence...

  14. Density functional and neural network analysis

    DEFF Research Database (Denmark)

    Jalkanen, K. J.; Suhai, S.; Bohr, Henrik

    1997-01-01

    Density functional theory (DFT) calculations have been carried out for hydrated L-alanine, L-alanyl-L-alanine and N-acetyl L-alanine N'-methylamide and examined with respect to the effect of water on the structure, the vibrational frequencies, vibrational absorption (VA) and vibrational circular...

  15. Bispectral analysis: comparison of two windowing functions

    Science.gov (United States)

    Silvagni, D.; Djerroud, C.; Réveillé, T.; Gravier, E.

    2018-02-01

    Amongst all the normalized forms of bispectrum, the bicoherence is shown to be a very useful diagnostic tool in experimental studies of nonlinear wave interactions in plasma, as it measures the fraction of wave power due to the quadratic wave coupling in a self-excited fluctuation spectrum [1, 2]. In order to avoid spectral leakage, the application of a windowing function is needed during the bicoherence computation. Spectral leakage from statistically dependent components are of crucial importance in the discrimination between coupled and uncoupled modes, as they will introduce in the bicoherence spectrum phase-coupled modes which in reality do not exist. Therefore, the windowing function plays a key role in the bicoherence estimation. In this paper, two windowing methods are compared: the multiplication of the initial signal by the Hanning function and the subtraction of the straight line which links the two extremities of the signal. The influence of these two windowing methods on both the power spectrum and the bicoherence spectrum is showed. Although both methods give precise results, the Hanning function appears to be the more suitable window.

  16. Functional Foods Baseline and Requirements Analysis

    Science.gov (United States)

    Cooper, M. R.; Bermudez-Aguirre, L. D.; Douglas, G.

    2015-01-01

    Current spaceflight foods were evaluated to determine if their nutrient profile supports positioning as a functional food and if the stability of the bioactive compound within the food matrix over an extended shelf-life correlated with the expected storage duration during the mission. Specifically, the research aims were: Aim A. To determine the amount of each nutrient in representative spaceflight foods immediately after processing and at predetermined storage time to establish the current nutritional state. Aim B. To identify the requirements to develop foods that stabilize these nutrients such that required concentrations are maintained in the space food system throughout long duration missions (up to five years). Aim C. To coordinate collaborations with health and performance groups that may require functional foods as a countermeasure.

  17. Discriminant Function Analysis as a Proof for Sexual Dimorphism ...

    African Journals Online (AJOL)

    Background: Forensic scientists study human skeleton in legal setting. Discriminant function analysis has become important in forensic anthropology. The aim of this study was to determine the sex of adolescent Yoruba ethnic group of Nigeria using iscriminant function analysis. Methodology: One thousand (500 males and ...

  18. Some connections for manuals of empirical logic to functional analysis

    International Nuclear Information System (INIS)

    Cook, T.A.

    1981-01-01

    In this informal presentation, the theory of manuals of operations is connected with some familiar concepts in functional analysis; namely, base normed and order unit normed spaces. The purpose of this discussion is to present several general open problems which display the interplay of empirical logic with functional analysis. These are mathematical problems with direct physical interpretation. (orig./HSI)

  19. Classwide Functional Analysis and Treatment of Preschoolers' Disruptive Behavior

    Science.gov (United States)

    Poole, Veena Y.; Dufrene, Brad A.; Sterling, Heather E.; Tingstrom, Daniel H.; Hardy, Christina M.

    2012-01-01

    Relatively few functional assessment and intervention studies have been conducted in preschool classrooms with children of typical development who engage in high incidence problem behaviors. Moreover, limited studies have used functional assessment procedures with the class as the unit of analysis. This study included functional analyses and a…

  20. Continuous nowhere differentiable functions the monsters of analysis

    CERN Document Server

    Jarnicki, Marek

    2015-01-01

    This book covers the construction, analysis, and theory of continuous nowhere differentiable functions, comprehensively and accessibly. After illuminating the significance of the subject through an overview of its history, the reader is introduced to the sophisticated toolkit of ideas and tricks used to study the explicit continuous nowhere differentiable functions of Weierstrass, Takagi–van der Waerden, Bolzano, and others. Modern tools of functional analysis, measure theory, and Fourier analysis are applied to examine the generic nature of continuous nowhere differentiable functions, as well as linear structures within the (nonlinear) space of continuous nowhere differentiable functions. To round out the presentation, advanced techniques from several areas of mathematics are brought together to give a state-of-the-art analysis of Riemann’s continuous, and purportedly nowhere differentiable, function. For the reader’s benefit, claims requiring elaboration, and open problems, are clearly indicated. An a...

  1. [A functional analysis of healthcare auditors' skills in Venezuela, 2008].

    Science.gov (United States)

    Chirinos-Muñoz, Mónica S

    2010-10-01

    Using functional analysis for identifying the basic, working, specific and generic skills and values which a health service auditor must have. Implementing the functional analysis technique with 10 experts, identifying specific, basic, generic skills and values by means of deductive logic. A functional map was obtained which started by establishing a key purpose based on improving healthcare and service quality from which three key functions emerged. The main functions and skills' units were then broken down into the competitive elements defining what a health service auditor is able to do. This functional map (following functional analysis methodology) shows in detail the simple and complex tasks which a healthcare auditor should apply in the workplace, adopting a forward management approach for improving healthcare and health service quality. This methodology, expressing logical-deductive awareness raising, provides expert consensual information validating each element regarding overall skills.

  2. False Positive Functional Analysis Results as a Contributor of Treatment Failure during Functional Communication Training

    Science.gov (United States)

    Mann, Amanda J.; Mueller, Michael M.

    2009-01-01

    Research has shown that functional analysis results are beneficial for treatment selection because they identify reinforcers for severe behavior that can then be used to reinforce replacement behaviors either differentially or noncontingently. Theoretically then, if a reinforcer is identified in a functional analysis erroneously, a well researched…

  3. A Comparison of Functional Behavioral Assessment and Functional Analysis Methodology among Students with Mild Disabilities

    Science.gov (United States)

    Lewis, Timothy J.; Mitchell, Barbara S.; Harvey, Kristin; Green, Ambra; McKenzie, Jennifer

    2015-01-01

    Functional behavioral assessment (FBA) and functional analyses (FA) are grounded in the applied behavior analysis principle that posits problem behavior is functionally related to the environment in which it occurs and is maintained by either providing access to reinforcing outcomes or allowing the individual to avoid or escape that which they…

  4. Functional Analysis for Double Shell Tank (DST) Subsystems

    International Nuclear Information System (INIS)

    SMITH, D.F.

    2000-01-01

    This functional analysis identifies the hierarchy and describes the subsystem functions that support the Double-Shell Tank (DST) System described in HNF-SD-WM-TRD-007, System Specification for the Double-Shell Tank System. Because of the uncertainty associated with the need for upgrades of the existing catch tanks supporting the Waste Feed Delivery (WFD) mission, catch tank functions are not addressed in this document. The functions identified herein are applicable to the Phase 1 WFD mission only

  5. Function analysis for waste information systems

    International Nuclear Information System (INIS)

    Sexton, J.L.; Neal, C.T.; Heath, T.C.; Starling, C.D.

    1996-04-01

    This study has a two-fold purpose. It seeks to identify the functional requirements of a waste tracking information system and to find feasible alternatives for meeting those requirements on the Oak Ridge Reservation (ORR) and the Portsmouth (PORTS) and Paducah (PGDP) facilities; identify options that offer potential cost savings to the US government and also show opportunities for improved efficiency and effectiveness in managing waste information; and, finally, to recommend a practical course of action that can be immediately initiated. In addition to identifying relevant requirements, it also identifies any existing requirements that are currently not being completely met. Another aim of this study is to carry out preliminary benchmarking by contacting representative companies about their strategic directions in waste information. The information obtained from representatives of these organizations is contained in an appendix to the document; a full benchmarking effort, however, is beyond the intended scope of this study

  6. Bioprospecting and Functional Analysis of Neglected Environments

    DEFF Research Database (Denmark)

    Vogt, Josef Korbinian

    on Biological Diversity (explained in Chapter 3). Proteolytic enzymes – described in Chapter 4 – are the target for bioprospecting due to their high market value. Section II describes methods used for the analysis of metagenomic and RNA-seq datasets, including Manuscript I, which includes the taxonomic...... of arctic marine metagenomes reveals bacterial strategies for deep sea persistence (Manuscript II). Furthermore, this extreme environment is a fertile ground to mine for novel proteolytic enzymes. Manuscript III presents a bioinformatics approach to identify sequences for potential commercialization...

  7. Applications of functional analysis to optimal control problems

    International Nuclear Information System (INIS)

    Mizukami, K.

    1976-01-01

    Some basic concepts in functional analysis, a general norm, the Hoelder inequality, functionals and the Hahn-Banach theorem are described; a mathematical formulation of two optimal control problems is introduced by the method of functional analysis. The problem of time-optimal control systems with both norm constraints on control inputs and on state variables at discrete intermediate times is formulated as an L-problem in the theory of moments. The simplex method is used for solving a non-linear minimizing problem inherent in the functional analysis solution to this problem. Numerical results are presented for a train operation. The second problem is that of optimal control of discrete linear systems with quadratic cost functionals. The problem is concerned with the case of unconstrained control and fixed endpoints. This problem is formulated in terms of norms of functionals on suitable Banach spaces. (author)

  8. GOMA: functional enrichment analysis tool based on GO modules

    Institute of Scientific and Technical Information of China (English)

    Qiang Huang; Ling-Yun Wu; Yong Wang; Xiang-Sun Zhang

    2013-01-01

    Analyzing the function of gene sets is a critical step in interpreting the results of high-throughput experiments in systems biology.A variety of enrichment analysis tools have been developed in recent years,but most output a long list of significantly enriched terms that are often redundant,making it difficult to extract the most meaningful functions.In this paper,we present GOMA,a novel enrichment analysis method based on the new concept of enriched functional Gene Ontology (GO) modules.With this method,we systematically revealed functional GO modules,i.e.,groups of functionally similar GO terms,via an optimization model and then ranked them by enrichment scores.Our new method simplifies enrichment analysis results by reducing redundancy,thereby preventing inconsistent enrichment results among functionally similar terms and providing more biologically meaningful results.

  9. The Investigation of NPP Control and Monitoring Functional Analysis Applied to Functional Displays’ Implementation

    International Nuclear Information System (INIS)

    Yan, J.

    2015-01-01

    NPP Control and Monitoring System has been recognised as extreme and safe as well as large scale product, thus it was one of the most major design activities that fully, accurately and operationally functional analysis. The results of functional analysis would be employed as initial instruction through the whole lifecycle of NPP Control and Monitoring System. In this paper, it was discovered that several disadvantages of present functional analysis methods included FAST, The Subtract and Operate Procedure and Functional Procedure Method; owing to the identity methods enveloped here was the combination of Functional Tree and System Structure, as well as its decomposition steps; and RCS Inventory Control function which is defined as one of the most significant control functions in Advanced Light Water Reactor Utility Requirement Document has been employed to demonstrate the feasibility of this method; the analysis results of RCS Inventory function has been applied to direct the design and implementation of related displays, here the functional display of RCS Inventory Control function has been implemented on NuCON which is originated by SNPAS. Owing to the analyzing results, it would be ensured that the accuracy of information displayed to operators, thus the operator would be aware the condition of systems and then make the proper move to ensure the safety and productivity of NPP based on the received data. (author)

  10. Magnetothermoelastic creep analysis of functionally graded cylinders

    International Nuclear Information System (INIS)

    Loghman, A.; Ghorbanpour Arani, A.; Amir, S.; Vajedi, A.

    2010-01-01

    This paper describes time-dependent creep stress redistribution analysis of a thick-walled FGM cylinder placed in uniform magnetic and temperature fields and subjected to an internal pressure. The material creep, magnetic and mechanical properties through the radial graded direction are assumed to obey the simple power law variation. Total strains are assumed to be the sum of elastic, thermal and creep strains. Creep strains are time, temperature and stress dependent. Using equations of equilibrium, stress-strain and strain-displacement a differential equation, containing creep strains, for displacement is obtained. Ignoring creep strains in this differential equation a closed form solution for the displacement and initial magnetothermoelastic stresses at zero time is presented. Initial magnetothermoelastic stresses are illustrated for different material properties. Using Prandtl-Reuss relation in conjunction with the above differential equation and the Norton's law for the material uniaxial creep constitutive model, the radial displacement rate is obtained and then the radial and circumferential creep stress rates are calculated. Creep stress rates are plotted against dimensionless radius for different material properties. Using creep stress rates, stress redistributions are calculated iteratively using magnetothermoelastic stresses as initial values for stress redistributions. It has been found that radial stress redistributions are not significant for different material properties, however major redistributions occur for circumferential and effective stresses.

  11. Cost of product functions using analysis of value

    Directory of Open Access Journals (Sweden)

    Luminita Parv

    2016-09-01

    Full Text Available The value of use is a specific notion but of a great generality that makes the product be regarded as a complex system that transforms itself in time, thus undergoing evolution. Therefore, the product is important not in itself, but for the sake of the requirements it satisfies and for the functions it provides. In the analysis of value there are connections of a technical nature that implicitly lead to connections of an economic nature. Thus, the method of the ”analysis of value” will actually examine the cost of product functions, the aim of the method being the balance of functions costs on the basis of their importance for the product. Identifying the functions represents one of the important stages of the analysis of value. The difficulty in fixing the functions derives from the fact that there are not any rules clear enough for this activity, but only principles

  12. Use of linear discriminant function analysis in seed morphotype ...

    African Journals Online (AJOL)

    Use of linear discriminant function analysis in seed morphotype relationship study in 31 ... Data were collected on 100-seed weight, seed length and seed width. ... to the Mesoamerican gene pool, comprising the cultigroups Sieva-Big Lima, ...

  13. Spectral Analysis of Traffic Functions in Urban Areas

    Directory of Open Access Journals (Sweden)

    Florin Nemtanu

    2015-12-01

    Full Text Available The paper is focused on the Fourier transform application in urban traffic analysis and the use of said transform in traffic decomposition. The traffic function is defined as traffic flow generated by different categories of traffic participants. A Fourier analysis was elaborated in terms of identifying the main traffic function components, called traffic sub-functions. This paper presents the results of the method being applied in a real case situation, that is, an intersection in the city of Bucharest where the effect of a bus line was analysed. The analysis was done using different time scales, while three different traffic functions were defined to demonstrate the theoretical effect of the proposed method of analysis. An extension of the method is proposed to be applied in urban areas, especially in the areas covered by predictive traffic control.

  14. QCD analysis of structure functions in terms of Jacobi polynomials

    International Nuclear Information System (INIS)

    Krivokhizhin, V.G.; Kurlovich, S.P.; Savin, I.A.; Sidorov, A.V.; Skachkov, N.B.; Sanadze, V.V.

    1987-01-01

    A new method of QCD-analysis of singlet and nonsinglet structure functions based on their expansion in orthogonal Jacobi polynomials is proposed. An accuracy of the method is studied and its application is demonstrated using the structure function F 2 (x,Q 2 ) obtained by the EMC Collaboration from measurements with an iron target. (orig.)

  15. An introduction with medical applications to functional data analysis

    DEFF Research Database (Denmark)

    Sørensen, Helle; Goldsmith, Jeff; Sangalli, Laura M

    2013-01-01

    Functional data are data that can be represented by suitable functions, such as curves (potentially multi-dimensional) or surfaces. This paper gives an introduction to some basic but important techniques for the analysis of such data, and we apply the techniques to two datasets from biomedicine. ...

  16. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions

    DEFF Research Database (Denmark)

    Pendle, Alison F; Clark, Gillian P; Boon, Reinier

    2005-01-01

    The eukaryotic nucleolus is involved in ribosome biogenesis and a wide range of other RNA metabolism and cellular functions. An important step in the functional analysis of the nucleolus is to determine the complement of proteins of this nuclear compartment. Here, we describe the first proteomic ...

  17. Functional Principal Components Analysis of Shanghai Stock Exchange 50 Index

    Directory of Open Access Journals (Sweden)

    Zhiliang Wang

    2014-01-01

    Full Text Available The main purpose of this paper is to explore the principle components of Shanghai stock exchange 50 index by means of functional principal component analysis (FPCA. Functional data analysis (FDA deals with random variables (or process with realizations in the smooth functional space. One of the most popular FDA techniques is functional principal component analysis, which was introduced for the statistical analysis of a set of financial time series from an explorative point of view. FPCA is the functional analogue of the well-known dimension reduction technique in the multivariate statistical analysis, searching for linear transformations of the random vector with the maximal variance. In this paper, we studied the monthly return volatility of Shanghai stock exchange 50 index (SSE50. Using FPCA to reduce dimension to a finite level, we extracted the most significant components of the data and some relevant statistical features of such related datasets. The calculated results show that regarding the samples as random functions is rational. Compared with the ordinary principle component analysis, FPCA can solve the problem of different dimensions in the samples. And FPCA is a convenient approach to extract the main variance factors.

  18. Analyzing coastal environments by means of functional data analysis

    Science.gov (United States)

    Sierra, Carlos; Flor-Blanco, Germán; Ordoñez, Celestino; Flor, Germán; Gallego, José R.

    2017-07-01

    Here we used Functional Data Analysis (FDA) to examine particle-size distributions (PSDs) in a beach/shallow marine sedimentary environment in Gijón Bay (NW Spain). The work involved both Functional Principal Components Analysis (FPCA) and Functional Cluster Analysis (FCA). The grainsize of the sand samples was characterized by means of laser dispersion spectroscopy. Within this framework, FPCA was used as a dimension reduction technique to explore and uncover patterns in grain-size frequency curves. This procedure proved useful to describe variability in the structure of the data set. Moreover, an alternative approach, FCA, was applied to identify clusters and to interpret their spatial distribution. Results obtained with this latter technique were compared with those obtained by means of two vector approaches that combine PCA with CA (Cluster Analysis). The first method, the point density function (PDF), was employed after adapting a log-normal distribution to each PSD and resuming each of the density functions by its mean, sorting, skewness and kurtosis. The second applied a centered-log-ratio (clr) to the original data. PCA was then applied to the transformed data, and finally CA to the retained principal component scores. The study revealed functional data analysis, specifically FPCA and FCA, as a suitable alternative with considerable advantages over traditional vector analysis techniques in sedimentary geology studies.

  19. Function analysis and function assignment of NPP advanced main control room

    International Nuclear Information System (INIS)

    Zheng Mingguang; Xu Jijun

    2001-01-01

    The author addresses the requirements of function analysis and function assignment, which should be carried out in the design of main control room in nuclear power plant according to the design research of advanced main control room, then states its contents, functions, importance and necessity as well as how to implement these requirements and how to do design verification and validation in the design of advanced main control room of nuclear power plant

  20. Function modeling: improved raster analysis through delayed reading and function raster datasets

    Science.gov (United States)

    John S. Hogland; Nathaniel M. Anderson; J .Greg Jones

    2013-01-01

    Raster modeling is an integral component of spatial analysis. However, conventional raster modeling techniques can require a substantial amount of processing time and storage space, often limiting the types of analyses that can be performed. To address this issue, we have developed Function Modeling. Function Modeling is a new modeling framework that streamlines the...

  1. Functional Analysis in Public Schools: A Summary of 90 Functional Analyses

    Science.gov (United States)

    Mueller, Michael M.; Nkosi, Ajamu; Hine, Jeffrey F.

    2011-01-01

    Several review and epidemiological studies have been conducted over recent years to inform behavior analysts of functional analysis outcomes. None to date have closely examined demographic and clinical data for functional analyses conducted exclusively in public school settings. The current paper presents a data-based summary of 90 functional…

  2. Efficient Bayesian hierarchical functional data analysis with basis function approximations using Gaussian-Wishart processes.

    Science.gov (United States)

    Yang, Jingjing; Cox, Dennis D; Lee, Jong Soo; Ren, Peng; Choi, Taeryon

    2017-12-01

    Functional data are defined as realizations of random functions (mostly smooth functions) varying over a continuum, which are usually collected on discretized grids with measurement errors. In order to accurately smooth noisy functional observations and deal with the issue of high-dimensional observation grids, we propose a novel Bayesian method based on the Bayesian hierarchical model with a Gaussian-Wishart process prior and basis function representations. We first derive an induced model for the basis-function coefficients of the functional data, and then use this model to conduct posterior inference through Markov chain Monte Carlo methods. Compared to the standard Bayesian inference that suffers serious computational burden and instability in analyzing high-dimensional functional data, our method greatly improves the computational scalability and stability, while inheriting the advantage of simultaneously smoothing raw observations and estimating the mean-covariance functions in a nonparametric way. In addition, our method can naturally handle functional data observed on random or uncommon grids. Simulation and real studies demonstrate that our method produces similar results to those obtainable by the standard Bayesian inference with low-dimensional common grids, while efficiently smoothing and estimating functional data with random and high-dimensional observation grids when the standard Bayesian inference fails. In conclusion, our method can efficiently smooth and estimate high-dimensional functional data, providing one way to resolve the curse of dimensionality for Bayesian functional data analysis with Gaussian-Wishart processes. © 2017, The International Biometric Society.

  3. Complex analysis a modern first course in function theory

    CERN Document Server

    Muir, Jerry R

    2015-01-01

    A thorough introduction to the theory of complex functions emphasizing the beauty, power, and counterintuitive nature of the subject Written with a reader-friendly approach, Complex Analysis: A Modern First Course in Function Theory features a self-contained, concise development of the fundamental principles of complex analysis. After laying groundwork on complex numbers and the calculus and geometric mapping properties of functions of a complex variable, the author uses power series as a unifying theme to define and study the many rich and occasionally surprising properties of analytic fun

  4. Optimal choice of basis functions in the linear regression analysis

    International Nuclear Information System (INIS)

    Khotinskij, A.M.

    1988-01-01

    Problem of optimal choice of basis functions in the linear regression analysis is investigated. Step algorithm with estimation of its efficiency, which holds true at finite number of measurements, is suggested. Conditions, providing the probability of correct choice close to 1 are formulated. Application of the step algorithm to analysis of decay curves is substantiated. 8 refs

  5. Economic analysis of evolution/devolution of electronic devices functionality

    Directory of Open Access Journals (Sweden)

    Esipov A. S.

    2017-12-01

    Full Text Available the researcher of this article has presented the analysis of evolution/devolution of electronic devices functionality as well as the analysis of the current situation at the computers and mobile devices market, and some thoughts about new products. Is a newer device better? Are corporations producing really new devices or they are only the improvement of old ones.

  6. Trial-Based Functional Analysis Informs Treatment for Vocal Scripting.

    Science.gov (United States)

    Rispoli, Mandy; Brodhead, Matthew; Wolfe, Katie; Gregori, Emily

    2018-05-01

    Research on trial-based functional analysis has primarily focused on socially maintained challenging behaviors. However, procedural modifications may be necessary to clarify ambiguous assessment results. The purposes of this study were to evaluate the utility of iterative modifications to trial-based functional analysis on the identification of putative reinforcement and subsequent treatment for vocal scripting. For all participants, modifications to the trial-based functional analysis identified a primary function of automatic reinforcement. The structure of the trial-based format led to identification of social attention as an abolishing operation for vocal scripting. A noncontingent attention treatment was evaluated using withdrawal designs for each participant. This noncontingent attention treatment resulted in near zero levels of vocal scripting for all participants. Implications for research and practice are presented.

  7. Apply Functional Modelling to Consequence Analysis in Supervision Systems

    DEFF Research Database (Denmark)

    Zhang, Xinxin; Lind, Morten; Gola, Giulio

    2013-01-01

    This paper will first present the purpose and goals of applying functional modelling approach to consequence analysis by adopting Multilevel Flow Modelling (MFM). MFM Models describe a complex system in multiple abstraction levels in both means-end dimension and whole-part dimension. It contains...... consequence analysis to practical or online applications in supervision systems. It will also suggest a multiagent solution as the integration architecture for developing tools to facilitate the utilization results of functional consequence analysis. Finally a prototype of the multiagent reasoning system...... causal relations between functions and goals. A rule base system can be developed to trace the causal relations and perform consequence propagations. This paper will illustrate how to use MFM for consequence reasoning by using rule base technology and describe the challenges for integrating functional...

  8. Analysis of Lamellar Structures with Application of Generalized Functions

    Directory of Open Access Journals (Sweden)

    Kipiani Gela

    2016-12-01

    Full Text Available Theory of differential equations in respect of the functional area is based on the basic concepts on generalized functions and splines. There are some basic concepts related to the theory of generalized functions and their properties are considered in relation to the rod systems and lamellar structures. The application of generalized functions gives the possibility to effectively calculate step-variable stiffness lamellar structures. There are also widely applied structures, in that several in which a number of parallel load bearing layers are interconnected by discrete-elastic links. For analysis of system under study, such as design diagrams, there are applied discrete and discrete-continual models.

  9. On Special Functions in the Context of Clifford Analysis

    Science.gov (United States)

    Malonek, H. R.; Falcão, M. I.

    2010-09-01

    Considering the foundation of Quaternionic Analysis by R. Fueter and his collaborators in the beginning of the 1930s as starting point of Clifford Analysis, we can look back to 80 years of work in this field. However the interest in multivariate analysis using Clifford algebras only started to grow significantly in the 70s. Since then a great amount of papers on Clifford Analysis referring different classes of Special Functions have appeared. This situation may have been triggered by a more systematic treatment of monogenic functions by their multiple series development derived from Gegenbauer or associated Legendre polynomials (and not only by their integral representation). Also approaches to Special Functions by means of algebraic methods, either Lie algebras or through Lie groups and symmetric spaces gained by that time importance and influenced their treatment in Clifford Analysis. In our talk we will rely on the generalization of the classical approach to Special Functions through differential equations with respect to the hypercomplex derivative, which is a more recently developed tool in Clifford Analysis. In this context special attention will be payed to the role of Special Functions as intermediator between continuous and discrete mathematics. This corresponds to a more recent trend in combinatorics, since it has been revealed that many algebraic structures have hidden combinatorial underpinnings.

  10. Square function analysis of the Inductor-Converter Bridge

    International Nuclear Information System (INIS)

    Ehsani, M.; Kustom, R.L.

    1979-03-01

    The transfer of energy between two superconducting coils can be controlled with an Inductor-Converter Bridge (ICB) by changing the relative timing between the storage side bridge and the load side bridge. The average voltages on the coils have been previously derived as a function of relative timing between the two halves of the bridges and the relative currents in the two coils using a one-line, harmonic current source representation of each coil and its bridge network. Since the coil current in each of the ICB phases appears as bipolar rectangular pulses, an analysis based on unit step functions has been developed. The unit step function analysis leads to simple polynomial expressions relating the average coil voltages to relative timing. The new derivations are shown to have the same harmonic representation as previously developed. The polynomial expressions are more compatible to microprocessor control than are the harmonic function expressions

  11. A Unified Approach to Functional Principal Component Analysis and Functional Multiple-Set Canonical Correlation.

    Science.gov (United States)

    Choi, Ji Yeh; Hwang, Heungsun; Yamamoto, Michio; Jung, Kwanghee; Woodward, Todd S

    2017-06-01

    Functional principal component analysis (FPCA) and functional multiple-set canonical correlation analysis (FMCCA) are data reduction techniques for functional data that are collected in the form of smooth curves or functions over a continuum such as time or space. In FPCA, low-dimensional components are extracted from a single functional dataset such that they explain the most variance of the dataset, whereas in FMCCA, low-dimensional components are obtained from each of multiple functional datasets in such a way that the associations among the components are maximized across the different sets. In this paper, we propose a unified approach to FPCA and FMCCA. The proposed approach subsumes both techniques as special cases. Furthermore, it permits a compromise between the techniques, such that components are obtained from each set of functional data to maximize their associations across different datasets, while accounting for the variance of the data well. We propose a single optimization criterion for the proposed approach, and develop an alternating regularized least squares algorithm to minimize the criterion in combination with basis function approximations to functions. We conduct a simulation study to investigate the performance of the proposed approach based on synthetic data. We also apply the approach for the analysis of multiple-subject functional magnetic resonance imaging data to obtain low-dimensional components of blood-oxygen level-dependent signal changes of the brain over time, which are highly correlated across the subjects as well as representative of the data. The extracted components are used to identify networks of neural activity that are commonly activated across the subjects while carrying out a working memory task.

  12. The Necessity of Functional Analysis for Space Exploration Programs

    Science.gov (United States)

    Morris, A. Terry; Breidenthal, Julian C.

    2011-01-01

    As NASA moves toward expanded commercial spaceflight within its human exploration capability, there is increased emphasis on how to allocate responsibilities between government and commercial organizations to achieve coordinated program objectives. The practice of program-level functional analysis offers an opportunity for improved understanding of collaborative functions among heterogeneous partners. Functional analysis is contrasted with the physical analysis more commonly done at the program level, and is shown to provide theoretical performance, risk, and safety advantages beneficial to a government-commercial partnership. Performance advantages include faster convergence to acceptable system solutions; discovery of superior solutions with higher commonality, greater simplicity and greater parallelism by substituting functional for physical redundancy to achieve robustness and safety goals; and greater organizational cohesion around program objectives. Risk advantages include avoidance of rework by revelation of some kinds of architectural and contractual mismatches before systems are specified, designed, constructed, or integrated; avoidance of cost and schedule growth by more complete and precise specifications of cost and schedule estimates; and higher likelihood of successful integration on the first try. Safety advantages include effective delineation of must-work and must-not-work functions for integrated hazard analysis, the ability to formally demonstrate completeness of safety analyses, and provably correct logic for certification of flight readiness. The key mechanism for realizing these benefits is the development of an inter-functional architecture at the program level, which reveals relationships between top-level system requirements that would otherwise be invisible using only a physical architecture. This paper describes the advantages and pitfalls of functional analysis as a means of coordinating the actions of large heterogeneous organizations

  13. Determination of resonance parameters in QCD by functional analysis methods

    International Nuclear Information System (INIS)

    Ciulli, S.; Geniet, F.; Papadopoulos, N.A.; Schilcher, K.

    1988-01-01

    A mathematically rigorous method based on functional analysis is used to determine resonance parameters of an amplitude from its given asymptotic expression in the space-like region. This method is checked on a model amplitude where both the asymptotic expression and the exact function are known. This method is then applied to the determination of the mass and the width of the ρ-meson from the corresponding space-like asymptotic QCD expression. (orig.)

  14. Local properties of analytic functions and non-standard analysis

    International Nuclear Information System (INIS)

    O'Brian, N.R.

    1976-01-01

    This is an expository account which shows how the methods of non-standard analysis can be applied to prove the Nullstellensatz for germs of analytic functions. This method of proof was discovered originally by Abraham Robinson. The necessary concepts from model theory are described in some detail and the Nullstellensatz is proved by investigating the relation between the set of infinitesimal elements in the complex n-plane and the spectrum of the ring of germs of analytic functions. (author)

  15. Functional Parallel Factor Analysis for Functions of One- and Two-dimensional Arguments.

    Science.gov (United States)

    Choi, Ji Yeh; Hwang, Heungsun; Timmerman, Marieke E

    2018-03-01

    Parallel factor analysis (PARAFAC) is a useful multivariate method for decomposing three-way data that consist of three different types of entities simultaneously. This method estimates trilinear components, each of which is a low-dimensional representation of a set of entities, often called a mode, to explain the maximum variance of the data. Functional PARAFAC permits the entities in different modes to be smooth functions or curves, varying over a continuum, rather than a collection of unconnected responses. The existing functional PARAFAC methods handle functions of a one-dimensional argument (e.g., time) only. In this paper, we propose a new extension of functional PARAFAC for handling three-way data whose responses are sequenced along both a two-dimensional domain (e.g., a plane with x- and y-axis coordinates) and a one-dimensional argument. Technically, the proposed method combines PARAFAC with basis function expansion approximations, using a set of piecewise quadratic finite element basis functions for estimating two-dimensional smooth functions and a set of one-dimensional basis functions for estimating one-dimensional smooth functions. In a simulation study, the proposed method appeared to outperform the conventional PARAFAC. We apply the method to EEG data to demonstrate its empirical usefulness.

  16. Extracting neuronal functional network dynamics via adaptive Granger causality analysis.

    Science.gov (United States)

    Sheikhattar, Alireza; Miran, Sina; Liu, Ji; Fritz, Jonathan B; Shamma, Shihab A; Kanold, Patrick O; Babadi, Behtash

    2018-04-24

    Quantifying the functional relations between the nodes in a network based on local observations is a key challenge in studying complex systems. Most existing time series analysis techniques for this purpose provide static estimates of the network properties, pertain to stationary Gaussian data, or do not take into account the ubiquitous sparsity in the underlying functional networks. When applied to spike recordings from neuronal ensembles undergoing rapid task-dependent dynamics, they thus hinder a precise statistical characterization of the dynamic neuronal functional networks underlying adaptive behavior. We develop a dynamic estimation and inference paradigm for extracting functional neuronal network dynamics in the sense of Granger, by integrating techniques from adaptive filtering, compressed sensing, point process theory, and high-dimensional statistics. We demonstrate the utility of our proposed paradigm through theoretical analysis, algorithm development, and application to synthetic and real data. Application of our techniques to two-photon Ca 2+ imaging experiments from the mouse auditory cortex reveals unique features of the functional neuronal network structures underlying spontaneous activity at unprecedented spatiotemporal resolution. Our analysis of simultaneous recordings from the ferret auditory and prefrontal cortical areas suggests evidence for the role of rapid top-down and bottom-up functional dynamics across these areas involved in robust attentive behavior.

  17. Landscape function analysis as a base of rural development strategies

    Directory of Open Access Journals (Sweden)

    Filepné Kovács Krisztina

    2017-11-01

    Full Text Available Research on ecosystem services and landscape functions are highly important in landscape ecology, landscape planning and open space design. The terms of ecosystem service and landscape function have been evolved parallel to each other in the scientific literature but have different focus. The term of landscape functions evolved from the scientific field of landscape ecology; it reflects the goods and services provided by regions, landscapes where the cultural, economic factors are important as well. As a framework assessment method with additional economic assessment, a landscape function analysis could be an additional tool of rural development, as it gives a complex analysis of multiple aspects, thus it is highly appropriate to explore, analyze the potentials, resources and limits of landscapes and land use systems. In the current research a landscape function analysis was compared with the rural development strategies in Hungarian micro-regions. We focused on the level of landscape functions and the objectives of the rural development strategies of the study areas. The local development strategies do not focus on territorial differences nor potentials evolving from natural, cultural resources or local constrains. The only exception is tourism development, where in some cases there is a holistic spatial approach which intends to develop the region as a whole.

  18. Identifying functions for ex-core neutron noise analysis

    International Nuclear Information System (INIS)

    Avila, J.M.; Oliveira, J.C.

    1987-01-01

    A method of performing the phase analysis of signals arising from neutron detectors placed in the periphery of a pressurized water reactor is proposed. It consists in the definition of several identifying functions, based on the phases of cross power spectral densities corresponding to four ex-core neutron detectors. Each of these functions enhances the appearance of different sources of noise. The method, applied to the ex-core neutron fluctuation analysis of a French PWR, proved to be very useful as it allows quick recognition of various patterns in the power spectral densities. (orig.) [de

  19. Meeting the reactor operator's information needs using functional analysis

    International Nuclear Information System (INIS)

    Nelson, W.R.; Clark, M.T.

    1980-01-01

    Since the accident at Three Mile Island, many ideas have been proposed for assisting the reactor operator during emergency situations. However, some of the suggested remedies do not alleviate an important shortcoming of the TMI control room: the operators were not presented with the information they needed in a manner which would allow prompt diagnosis of the problem. To address this problem, functional analysis is being applied at the LOFT facility to ensure that the operator's information needs are being met in his procedures and graphic displays. This paper summarizes the current applications of functional analysis at LOFT

  20. Polynomial regression analysis and significance test of the regression function

    International Nuclear Information System (INIS)

    Gao Zhengming; Zhao Juan; He Shengping

    2012-01-01

    In order to analyze the decay heating power of a certain radioactive isotope per kilogram with polynomial regression method, the paper firstly demonstrated the broad usage of polynomial function and deduced its parameters with ordinary least squares estimate. Then significance test method of polynomial regression function is derived considering the similarity between the polynomial regression model and the multivariable linear regression model. Finally, polynomial regression analysis and significance test of the polynomial function are done to the decay heating power of the iso tope per kilogram in accord with the authors' real work. (authors)

  1. Characterization of technical surfaces by structure function analysis

    Science.gov (United States)

    Kalms, Michael; Kreis, Thomas; Bergmann, Ralf B.

    2018-03-01

    The structure function is a tool for characterizing technical surfaces that exhibits a number of advantages over Fourierbased analysis methods. So it is optimally suited for analyzing the height distributions of surfaces measured by full-field non-contacting methods. The structure function is thus a useful method to extract global or local criteria like e. g. periodicities, waviness, lay, or roughness to analyze and evaluate technical surfaces. After the definition of line- and area-structure function and offering effective procedures for their calculation this paper presents examples using simulated and measured data of technical surfaces including aircraft parts.

  2. Measuring coalition functioning: refining constructs through factor analysis.

    Science.gov (United States)

    Brown, Louis D; Feinberg, Mark E; Greenberg, Mark T

    2012-08-01

    Internal and external coalition functioning is an important predictor of coalition success that has been linked to perceived coalition effectiveness, coalition goal achievement, coalition ability to support evidence-based programs, and coalition sustainability. Understanding which aspects of coalition functioning best predict coalition success requires the development of valid measures of empirically unique coalition functioning constructs. The goal of the present study is to examine and refine the psychometric properties of coalition functioning constructs in the following six domains: leadership, interpersonal relationships, task focus, participation benefits/costs, sustainability planning, and community support. The authors used factor analysis to identify problematic items in our original measure and then piloted new items and scales to create a more robust, psychometrically sound, multidimensional measure of coalition functioning. Scales displayed good construct validity through correlations with other measures. Discussion considers the strengths and weaknesses of the refined instrument.

  3. Fractals and spectra related to fourier analysis and function spaces

    CERN Document Server

    Triebel, Hans

    1997-01-01

    Fractals and Spectra Hans Triebel This book deals with the symbiotic relationship between the theory of function spaces, fractal geometry, and spectral theory of (fractal) pseudodifferential operators as it has emerged quite recently. Atomic and quarkonial (subatomic) decompositions in scalar and vector valued function spaces on the euclidean n-space pave the way to study properties (compact embeddings, entropy numbers) of function spaces on and of fractals. On this basis, distributions of eigenvalues of fractal (pseudo)differential operators are investigated. Diverse versions of fractal drums are played. The book is directed to mathematicians interested in functional analysis, the theory of function spaces, fractal geometry, partial and pseudodifferential operators, and, in particular, in how these domains are interrelated. ------ It is worth mentioning that there is virtually no literature on this topic and hence the most of the presented material is published here the first time. - Zentralblatt MATH (…) ...

  4. Functional linear models for association analysis of quantitative traits.

    Science.gov (United States)

    Fan, Ruzong; Wang, Yifan; Mills, James L; Wilson, Alexander F; Bailey-Wilson, Joan E; Xiong, Momiao

    2013-11-01

    Functional linear models are developed in this paper for testing associations between quantitative traits and genetic variants, which can be rare variants or common variants or the combination of the two. By treating multiple genetic variants of an individual in a human population as a realization of a stochastic process, the genome of an individual in a chromosome region is a continuum of sequence data rather than discrete observations. The genome of an individual is viewed as a stochastic function that contains both linkage and linkage disequilibrium (LD) information of the genetic markers. By using techniques of functional data analysis, both fixed and mixed effect functional linear models are built to test the association between quantitative traits and genetic variants adjusting for covariates. After extensive simulation analysis, it is shown that the F-distributed tests of the proposed fixed effect functional linear models have higher power than that of sequence kernel association test (SKAT) and its optimal unified test (SKAT-O) for three scenarios in most cases: (1) the causal variants are all rare, (2) the causal variants are both rare and common, and (3) the causal variants are common. The superior performance of the fixed effect functional linear models is most likely due to its optimal utilization of both genetic linkage and LD information of multiple genetic variants in a genome and similarity among different individuals, while SKAT and SKAT-O only model the similarities and pairwise LD but do not model linkage and higher order LD information sufficiently. In addition, the proposed fixed effect models generate accurate type I error rates in simulation studies. We also show that the functional kernel score tests of the proposed mixed effect functional linear models are preferable in candidate gene analysis and small sample problems. The methods are applied to analyze three biochemical traits in data from the Trinity Students Study. © 2013 WILEY

  5. A Novel Synchronization-Based Approach for Functional Connectivity Analysis

    Directory of Open Access Journals (Sweden)

    Angela Lombardi

    2017-01-01

    Full Text Available Complex network analysis has become a gold standard to investigate functional connectivity in the human brain. Popular approaches for quantifying functional coupling between fMRI time series are linear zero-lag correlation methods; however, they might reveal only partial aspects of the functional links between brain areas. In this work, we propose a novel approach for assessing functional coupling between fMRI time series and constructing functional brain networks. A phase space framework is used to map couples of signals exploiting their cross recurrence plots (CRPs to compare the trajectories of the interacting systems. A synchronization metric is extracted from the CRP to assess the coupling behavior of the time series. Since the functional communities of a healthy population are expected to be highly consistent for the same task, we defined functional networks of task-related fMRI data of a cohort of healthy subjects and applied a modularity algorithm in order to determine the community structures of the networks. The within-group similarity of communities is evaluated to verify whether such new metric is robust enough against noise. The synchronization metric is also compared with Pearson’s correlation coefficient and the detected communities seem to better reflect the functional brain organization during the specific task.

  6. Prediction of functional sites in proteins using conserved functional group analysis.

    Science.gov (United States)

    Innis, C Axel; Anand, A Prem; Sowdhamini, R

    2004-04-02

    A detailed knowledge of a protein's functional site is an absolute prerequisite for understanding its mode of action at the molecular level. However, the rapid pace at which sequence and structural information is being accumulated for proteins greatly exceeds our ability to determine their biochemical roles experimentally. As a result, computational methods are required which allow for the efficient processing of the evolutionary information contained in this wealth of data, in particular that related to the nature and location of functionally important sites and residues. The method presented here, referred to as conserved functional group (CFG) analysis, relies on a simplified representation of the chemical groups found in amino acid side-chains to identify functional sites from a single protein structure and a number of its sequence homologues. We show that CFG analysis can fully or partially predict the location of functional sites in approximately 96% of the 470 cases tested and that, unlike other methods available, it is able to tolerate wide variations in sequence identity. In addition, we discuss its potential in a structural genomics context, where automation, scalability and efficiency are critical, and an increasing number of protein structures are determined with no prior knowledge of function. This is exemplified by our analysis of the hypothetical protein Ydde_Ecoli, whose structure was recently solved by members of the North East Structural Genomics consortium. Although the proposed active site for this protein needs to be validated experimentally, this example illustrates the scope of CFG analysis as a general tool for the identification of residues likely to play an important role in a protein's biochemical function. Thus, our method offers a convenient solution to rapidly and automatically process the vast amounts of data that are beginning to emerge from structural genomics projects.

  7. Semen analysis and sperm function tests: How much to test?

    Directory of Open Access Journals (Sweden)

    S S Vasan

    2011-01-01

    Full Text Available Semen analysis as an integral part of infertility investigations is taken as a surrogate measure for male fecundity in clinical andrology, male fertility, and pregnancy risk assessments. Clearly, laboratory seminology is still very much in its infancy. In as much as the creation of a conventional semen profile will always represent the foundations of male fertility evaluation, the 5th edition of the World Health Organization (WHO manual is a definitive statement on how such assessments should be carried out and how the quality should be controlled. A major advance in this new edition of the WHO manual, resolving the most salient critique of previous editions, is the development of the first well-defined reference ranges for semen analysis based on the analysis of over 1900 recent fathers. The methodology used in the assessment of the usual variables in semen analysis is described, as are many of the less common, but very valuable, sperm function tests. Sperm function testing is used to determine if the sperm have the biologic capacity to perform the tasks necessary to reach and fertilize ova and ultimately result in live births. A variety of tests are available to evaluate different aspects of these functions. To accurately use these functional assays, the clinician must understand what the tests measure, what the indications are for the assays, and how to interpret the results to direct further testing or patient management.

  8. Functional Interaction Network Construction and Analysis for Disease Discovery.

    Science.gov (United States)

    Wu, Guanming; Haw, Robin

    2017-01-01

    Network-based approaches project seemingly unrelated genes or proteins onto a large-scale network context, therefore providing a holistic visualization and analysis platform for genomic data generated from high-throughput experiments, reducing the dimensionality of data via using network modules and increasing the statistic analysis power. Based on the Reactome database, the most popular and comprehensive open-source biological pathway knowledgebase, we have developed a highly reliable protein functional interaction network covering around 60 % of total human genes and an app called ReactomeFIViz for Cytoscape, the most popular biological network visualization and analysis platform. In this chapter, we describe the detailed procedures on how this functional interaction network is constructed by integrating multiple external data sources, extracting functional interactions from human curated pathway databases, building a machine learning classifier called a Naïve Bayesian Classifier, predicting interactions based on the trained Naïve Bayesian Classifier, and finally constructing the functional interaction database. We also provide an example on how to use ReactomeFIViz for performing network-based data analysis for a list of genes.

  9. Uncertainty importance analysis using parametric moment ratio functions.

    Science.gov (United States)

    Wei, Pengfei; Lu, Zhenzhou; Song, Jingwen

    2014-02-01

    This article presents a new importance analysis framework, called parametric moment ratio function, for measuring the reduction of model output uncertainty when the distribution parameters of inputs are changed, and the emphasis is put on the mean and variance ratio functions with respect to the variances of model inputs. The proposed concepts efficiently guide the analyst to achieve a targeted reduction on the model output mean and variance by operating on the variances of model inputs. The unbiased and progressive unbiased Monte Carlo estimators are also derived for the parametric mean and variance ratio functions, respectively. Only a set of samples is needed for implementing the proposed importance analysis by the proposed estimators, thus the computational cost is free of input dimensionality. An analytical test example with highly nonlinear behavior is introduced for illustrating the engineering significance of the proposed importance analysis technique and verifying the efficiency and convergence of the derived Monte Carlo estimators. Finally, the moment ratio function is applied to a planar 10-bar structure for achieving a targeted 50% reduction of the model output variance. © 2013 Society for Risk Analysis.

  10. Functional MRI experiments : acquisition, analysis and interpretation of data

    NARCIS (Netherlands)

    Ramsey, NF; Hoogduin, H; Jansma, JM

    2002-01-01

    Functional MRI is widely used to address basic and clinical neuroscience questions. In the key domains of fMRI experiments, i.e. acquisition, processing and analysis, and interpretation of data, developments are ongoing. The main issues are sensitivity for changes in fMRI signal that are associated

  11. Genome-wide identification, functional analysis and expression ...

    African Journals Online (AJOL)

    Fuyou Fu

    2013-07-24

    Jul 24, 2013 ... Key words: ABC transporter, potato, pleiotropic drug resistance (PDR), RNA-seq. INTRODUCTION ..... of relative transcript accumulation of each of 55 PDR genes as determined by RNA-seq analysis are presented as a heatmap, with ... specificities provide clues to the endogenous function of the individual ...

  12. Knowledge-based analysis of functional impacts of mutations in ...

    Indian Academy of Sciences (India)

    Knowledge-based analysis of functional impacts of mutations in microRNA seed regions. Supplementary figure 1. Summary of predicted miRNA targets from ... All naturally occurred SNPs in seed regions of human miRNAs. The information of the columns is given in the second sheet. Hihly expressed miRNAs are ...

  13. Expression and functional analysis of apoptosis-related gene ...

    African Journals Online (AJOL)

    Administrator

    2011-10-19

    Oct 19, 2011 ... conducted a molecular cloning and functional analysis to study a specific silkworm gene BmICAD related to apoptosis. .... blocking with 5% non-fat milk for 1 h at room temperature, the .... requirements for all next experiments.

  14. Assessing the Utility of a Demand Assessment for Functional Analysis

    Science.gov (United States)

    Roscoe, Eileen M.; Rooker, Griffin W.; Pence, Sacha T.; Longworth, Lynlea J.

    2009-01-01

    We evaluated the utility of an assessment for identifying tasks for the functional analysis demand condition with 4 individuals who had been diagnosed with autism. During the demand assessment, a therapist presented a variety of tasks, and observers measured problem behavior and compliance to identify demands associated with low levels of…

  15. The Maslov index in weak symplectic functional analysis

    DEFF Research Database (Denmark)

    Booss-Bavnbek, Bernhelm; Zhu, Chaofeng

    2013-01-01

    We recall the Chernoff-Marsden definition of weak symplectic structure and give a rigorous treatment of the functional analysis and geometry of weak symplectic Banach spaces. We define the Maslov index of a continuous path of Fredholm pairs of Lagrangian subspaces in continuously varying Banach...

  16. Effects of Language of Implementation on Functional Analysis Outcomes

    Science.gov (United States)

    Rispoli, Mandy; O'Reilly, Mark; Lang, Russell; Sigafoos, Jeff; Mulloy, Austin; Aguilar, Jeannie; Singer, George

    2011-01-01

    This study evaluated the influence of language of implementation on functional analysis outcomes for a child with a severe intellectual disability from a Spanish-speaking home. Challenging behavior was assessed during 5-min sessions under 4 conditions; attention, play-verbal, play-nonverbal, and demand and across 2 phases; implementation in…

  17. Some Logical Metatheorems with Applications in Functional Analysis

    DEFF Research Database (Denmark)

    Kohlenbach, Ulrich

    2005-01-01

    In previous papers we have developed proof-theoretic techniques for extracting effective uniform bounds from large classes of ineffective existence proofs in functional analysis. Here `uniform' means independence from parameters in compact spaces. A recent case study in fixed-point theory...

  18. Multiresolution Analysis by Infinitely Differentiable Compactly Supported Functions

    Science.gov (United States)

    1992-09-01

    Math. Surveys 45:1 (1990), 87-120. [I] (;. Strang and G. Fix, A Fourier analysis of the finite element variational method. C.I.M.F. I 1 Ciclo 1971, in Constructi’c Aspects of Functional Analyszs ed. G. Geymonat 1973, 793-840. 10

  19. Functional Analysis and Treatment of Noncompliance by Preschool Children

    Science.gov (United States)

    Wilder, David A.; Harris, Carelle; Reagan, Renee; Rasey, Amy

    2007-01-01

    A functional analysis showed that noncompliance occurred most often for 2 preschoolers when it resulted in termination of a preferred activity, suggesting that noncompliance was maintained by positive reinforcement. A differential reinforcement procedure, which involved contingent access to coupons that could be exchanged for uninterrupted access…

  20. Mixed kernel function support vector regression for global sensitivity analysis

    Science.gov (United States)

    Cheng, Kai; Lu, Zhenzhou; Wei, Yuhao; Shi, Yan; Zhou, Yicheng

    2017-11-01

    Global sensitivity analysis (GSA) plays an important role in exploring the respective effects of input variables on an assigned output response. Amongst the wide sensitivity analyses in literature, the Sobol indices have attracted much attention since they can provide accurate information for most models. In this paper, a mixed kernel function (MKF) based support vector regression (SVR) model is employed to evaluate the Sobol indices at low computational cost. By the proposed derivation, the estimation of the Sobol indices can be obtained by post-processing the coefficients of the SVR meta-model. The MKF is constituted by the orthogonal polynomials kernel function and Gaussian radial basis kernel function, thus the MKF possesses both the global characteristic advantage of the polynomials kernel function and the local characteristic advantage of the Gaussian radial basis kernel function. The proposed approach is suitable for high-dimensional and non-linear problems. Performance of the proposed approach is validated by various analytical functions and compared with the popular polynomial chaos expansion (PCE). Results demonstrate that the proposed approach is an efficient method for global sensitivity analysis.

  1. Discrete-Trial Functional Analysis and Functional Communication Training with Three Adults with Intellectual Disabilities and Problem Behavior

    Science.gov (United States)

    Chezan, Laura C.; Drasgow, Erik; Martin, Christian A.

    2014-01-01

    We conducted a sequence of two studies on the use of discrete-trial functional analysis and functional communication training. First, we used discrete-trial functional analysis (DTFA) to identify the function of problem behavior in three adults with intellectual disabilities and problem behavior. Results indicated clear patterns of problem…

  2. LikelihoodLib - Fitting, Function Maximization, and Numerical Analysis

    CERN Document Server

    Smirnov, I B

    2001-01-01

    A new class library is designed for function maximization, minimization, solution of equations and for other problems related to mathematical analysis of multi-parameter functions by numerical iterative methods. When we search the maximum or another special point of a function, we may change and fit all parameters simultaneously, sequentially, recursively, or by any combination of these methods. The discussion is focused on the first the most complicated method, although the others are also supported by the library. For this method we apply: control of precision by interval computations; the calculation of derivatives either by differential arithmetic, or by the method of finite differences with the step lengths which provide suppression of the influence of numerical noise; possible synchronization of the subjective function calls with minimization of the number of iterations; competitive application of various methods for step calculation, and converging to the solution by many trajectories.

  3. An advanced probabilistic structural analysis method for implicit performance functions

    Science.gov (United States)

    Wu, Y.-T.; Millwater, H. R.; Cruse, T. A.

    1989-01-01

    In probabilistic structural analysis, the performance or response functions usually are implicitly defined and must be solved by numerical analysis methods such as finite element methods. In such cases, the most commonly used probabilistic analysis tool is the mean-based, second-moment method which provides only the first two statistical moments. This paper presents a generalized advanced mean value (AMV) method which is capable of establishing the distributions to provide additional information for reliability design. The method requires slightly more computations than the second-moment method but is highly efficient relative to the other alternative methods. In particular, the examples show that the AMV method can be used to solve problems involving non-monotonic functions that result in truncated distributions.

  4. Real analysis series, functions of several variables, and applications

    CERN Document Server

    Laczkovich, Miklós

    2017-01-01

    This book develops the theory of multivariable analysis, building on the single variable foundations established in the companion volume, Real Analysis: Foundations and Functions of One Variable. Together, these volumes form the first English edition of the popular Hungarian original, Valós Analízis I & II, based on courses taught by the authors at Eötvös Loránd University, Hungary, for more than 30 years. Numerous exercises are included throughout, offering ample opportunities to master topics by progressing from routine to difficult problems. Hints or solutions to many of the more challenging exercises make this book ideal for independent study, or further reading. Intended as a sequel to a course in single variable analysis, this book builds upon and expands these ideas into higher dimensions. The modular organization makes this text adaptable for either a semester or year-long introductory course. Topics include: differentiation and integration of functions of several variables; infinite numerica...

  5. Colombeau's generalized functions and non-standard analysis

    International Nuclear Information System (INIS)

    Todorov, T.D.

    1987-10-01

    Using some methods of the Non-Standard Analysis we modify one of Colombeau's classes of generalized functions. As a result we define a class ε-circumflex of the so-called meta-functions which possesses all good properties of Colombeau's generalized functions, i.e. (i) ε-circumflex is an associative and commutative algebra over the system of the so-called complex meta-numbers C-circumflex; (ii) Every meta-function has partial derivatives of any order (which are meta-functions again); (iii) Every meta-function is integrable on any compact set of R n and the integral is a number from C-circumflex; (iv) ε-circumflex contains all tempered distributions S', i.e. S' is contained in ε' isomorphically with respect to all linear operations (including the differentiation). Thus, within the class ε-circumflex the problem of multiplication of the tempered distributions is satisfactorily solved (every two distributions in S' have a well-defined product in ε-circumflex). The crucial point is that C-circumflex is a field in contrast to the system of Colombeau's generalized numbers C-bar which is a ring only (C-bar is the counterpart of C-circumflex in Colombeau's theory). In this way we simplify and improve slightly the properties of the integral and notion of ''values of the meta-functions'' as well as the properties of the whole class ε-circumflex itself if compared with the original Colombeau theory. And, what is maybe more important, we clarify the connection between the Non-Standard Analysis and Colombeau's theory of new generalized functions in the framework of which the problem of multiplication of distributions was recently solved. (author). 14 refs

  6. Confirmatory factor analysis of the female sexual function index.

    Science.gov (United States)

    Opperman, Emily A; Benson, Lindsay E; Milhausen, Robin R

    2013-01-01

    The Female Sexual Functioning Index (Rosen et al., 2000 ) was designed to assess the key dimensions of female sexual functioning using six domains: desire, arousal, lubrication, orgasm, satisfaction, and pain. A full-scale score was proposed to represent women's overall sexual function. The fifth revision to the Diagnostic and Statistical Manual (DSM) is currently underway and includes a proposal to combine desire and arousal problems. The objective of this article was to evaluate and compare four models of the Female Sexual Functioning Index: (a) single-factor model, (b) six-factor model, (c) second-order factor model, and (4) five-factor model combining the desire and arousal subscales. Cross-sectional and observational data from 85 women were used to conduct a confirmatory factor analysis on the Female Sexual Functioning Index. Local and global goodness-of-fit measures, the chi-square test of differences, squared multiple correlations, and regression weights were used. The single-factor model fit was not acceptable. The original six-factor model was confirmed, and good model fit was found for the second-order and five-factor models. Delta chi-square tests of differences supported best fit for the six-factor model validating usage of the six domains. However, when revisions are made to the DSM-5, the Female Sexual Functioning Index can adapt to reflect these changes and remain a valid assessment tool for women's sexual functioning, as the five-factor structure was also supported.

  7. Advances in the indirect, descriptive, and experimental approaches to the functional analysis of problem behavior.

    Science.gov (United States)

    Wightman, Jade; Julio, Flávia; Virués-Ortega, Javier

    2014-05-01

    Experimental functional analysis is an assessment methodology to identify the environmental factors that maintain problem behavior in individuals with developmental disabilities and in other populations. Functional analysis provides the basis for the development of reinforcement-based approaches to treatment. This article reviews the procedures, validity, and clinical implementation of the methodological variations of functional analysis and function-based interventions. We present six variations of functional analysis methodology in addition to the typical functional analysis: brief functional analysis, single-function tests, latency-based functional analysis, functional analysis of precursors, and trial-based functional analysis. We also present the three general categories of function-based interventions: extinction, antecedent manipulation, and differential reinforcement. Functional analysis methodology is a valid and efficient approach to the assessment of problem behavior and the selection of treatment strategies.

  8. multi scale analysis of a function by neural networks elementary derivatives functions

    International Nuclear Information System (INIS)

    Chikhi, A.; Gougam, A.; Chafa, F.

    2006-01-01

    Recently, the wavelet network has been introduced as a special neural network supported by the wavelet theory . Such networks constitute a tool for function approximation problems as it has been already proved in reference . Our present work deals with this model, treating a multi scale analysis of a function. We have then used a linear expansion of a given function in wavelets, neglecting the usual translation parameters. We investigate two training operations. The first one consists on an optimization of the output synaptic layer, the second one, optimizing the output function with respect to scale parameters. We notice a temporary merging of the scale parameters leading to some interesting results : new elementary derivatives units emerge, representing a new elementary task, which is the derivative of the output task

  9. Consolidity analysis for fully fuzzy functions, matrices, probability and statistics

    Directory of Open Access Journals (Sweden)

    Walaa Ibrahim Gabr

    2015-03-01

    Full Text Available The paper presents a comprehensive review of the know-how for developing the systems consolidity theory for modeling, analysis, optimization and design in fully fuzzy environment. The solving of systems consolidity theory included its development for handling new functions of different dimensionalities, fuzzy analytic geometry, fuzzy vector analysis, functions of fuzzy complex variables, ordinary differentiation of fuzzy functions and partial fraction of fuzzy polynomials. On the other hand, the handling of fuzzy matrices covered determinants of fuzzy matrices, the eigenvalues of fuzzy matrices, and solving least-squares fuzzy linear equations. The approach demonstrated to be also applicable in a systematic way in handling new fuzzy probabilistic and statistical problems. This included extending the conventional probabilistic and statistical analysis for handling fuzzy random data. Application also covered the consolidity of fuzzy optimization problems. Various numerical examples solved have demonstrated that the new consolidity concept is highly effective in solving in a compact form the propagation of fuzziness in linear, nonlinear, multivariable and dynamic problems with different types of complexities. Finally, it is demonstrated that the implementation of the suggested fuzzy mathematics can be easily embedded within normal mathematics through building special fuzzy functions library inside the computational Matlab Toolbox or using other similar software languages.

  10. Lectures on functional analysis and the Lebesgue integral

    CERN Document Server

    Komornik, Vilmos

    2016-01-01

    This textbook, based on three series of lectures held by the author at the University of Strasbourg, presents functional analysis in a non-traditional way by generalizing elementary theorems of plane geometry to spaces of arbitrary dimension. This approach leads naturally to the basic notions and theorems. Most results are illustrated by the small ℓp spaces. The Lebesgue integral, meanwhile, is treated via the direct approach of Frigyes Riesz, whose constructive definition of measurable functions leads to optimal, clear-cut versions of the classical theorems of Fubini-Tonelli and Radon-Nikodým. Lectures on Functional Analysis and the Lebesgue Integral presents the most important topics for students, with short, elegant proofs. The exposition style follows the Hungarian mathematical tradition of Paul Erdős and others. The order of the first two parts, functional analysis and the Lebesgue integral, may be reversed. In the third and final part they are combined to study various spaces of continuous and integ...

  11. Informing the Structure of Executive Function in Children: A Meta-Analysis of Functional Neuroimaging Data

    Science.gov (United States)

    McKenna, Róisín; Rushe, T.; Woodcock, Kate A.

    2017-01-01

    The structure of executive function (EF) has been the focus of much debate for decades. What is more, the complexity and diversity provided by the developmental period only adds to this contention. The development of executive function plays an integral part in the expression of children's behavioral, cognitive, social, and emotional capabilities. Understanding how these processes are constructed during development allows for effective measurement of EF in this population. This meta-analysis aims to contribute to a better understanding of the structure of executive function in children. A coordinate-based meta-analysis was conducted (using BrainMap GingerALE 2.3), which incorporated studies administering functional magnetic resonance imaging (fMRI) during inhibition, switching, and working memory updating tasks in typical children (aged 6–18 years). The neural activation common across all executive tasks was compared to that shared by tasks pertaining only to inhibition, switching or updating, which are commonly considered to be fundamental executive processes. Results support the existence of partially separable but partially overlapping inhibition, switching, and updating executive processes at a neural level, in children over 6 years. Further, the shared neural activation across all tasks (associated with a proposed “unitary” component of executive function) overlapped to different degrees with the activation associated with each individual executive process. These findings provide evidence to support the suggestion that one of the most influential structural models of executive functioning in adults can also be applied to children of this age. However, the findings also call for careful consideration and measurement of both specific executive processes, and unitary executive function in this population. Furthermore, a need is highlighted for a new systematic developmental model, which captures the integrative nature of executive function in children. PMID

  12. Function-Oriented Mobile Malware Analysis as First Aid

    Directory of Open Access Journals (Sweden)

    Jae-wook Jang

    2016-01-01

    Full Text Available Recently, highly well-crafted mobile malware has arisen as mobile devices manage highly valuable and sensitive information. Currently, it is impossible to detect and prevent all malware because the amount of new malware continues to increase exponentially; malware detection methods need to improve in order to respond quickly and effectively to malware. For the quick response, revealing the main purpose or functions of captured malware is important; however, only few recent works have attempted to find malware’s main purpose. Our approach is designed to help with efficient and effective incident responses or countermeasure development by analyzing the main functions of malicious behavior. In this paper, we propose a novel method for function-oriented malware analysis approach based on analysis of suspicious API call patterns. Instead of extracting API call patterns for malware in each family, we focus on extracting such patterns for certain malicious functionalities. Our proposed method dumps memory sections where an application is allocated and extracts suspicious API sequences from bytecode by comparing with predefined suspicious API lists. By matching API call patterns with our functionality database, our method determines whether they are malicious. The experiment results demonstrate that our method performs well in detecting malware with high accuracy.

  13. FADTTS: functional analysis of diffusion tensor tract statistics.

    Science.gov (United States)

    Zhu, Hongtu; Kong, Linglong; Li, Runze; Styner, Martin; Gerig, Guido; Lin, Weili; Gilmore, John H

    2011-06-01

    The aim of this paper is to present a functional analysis of a diffusion tensor tract statistics (FADTTS) pipeline for delineating the association between multiple diffusion properties along major white matter fiber bundles with a set of covariates of interest, such as age, diagnostic status and gender, and the structure of the variability of these white matter tract properties in various diffusion tensor imaging studies. The FADTTS integrates five statistical tools: (i) a multivariate varying coefficient model for allowing the varying coefficient functions in terms of arc length to characterize the varying associations between fiber bundle diffusion properties and a set of covariates, (ii) a weighted least squares estimation of the varying coefficient functions, (iii) a functional principal component analysis to delineate the structure of the variability in fiber bundle diffusion properties, (iv) a global test statistic to test hypotheses of interest, and (v) a simultaneous confidence band to quantify the uncertainty in the estimated coefficient functions. Simulated data are used to evaluate the finite sample performance of FADTTS. We apply FADTTS to investigate the development of white matter diffusivities along the splenium of the corpus callosum tract and the right internal capsule tract in a clinical study of neurodevelopment. FADTTS can be used to facilitate the understanding of normal brain development, the neural bases of neuropsychiatric disorders, and the joint effects of environmental and genetic factors on white matter fiber bundles. The advantages of FADTTS compared with the other existing approaches are that they are capable of modeling the structured inter-subject variability, testing the joint effects, and constructing their simultaneous confidence bands. However, FADTTS is not crucial for estimation and reduces to the functional analysis method for the single measure. Copyright © 2011 Elsevier Inc. All rights reserved.

  14. Global sensitivity analysis of computer models with functional inputs

    International Nuclear Information System (INIS)

    Iooss, Bertrand; Ribatet, Mathieu

    2009-01-01

    Global sensitivity analysis is used to quantify the influence of uncertain model inputs on the response variability of a numerical model. The common quantitative methods are appropriate with computer codes having scalar model inputs. This paper aims at illustrating different variance-based sensitivity analysis techniques, based on the so-called Sobol's indices, when some model inputs are functional, such as stochastic processes or random spatial fields. In this work, we focus on large cpu time computer codes which need a preliminary metamodeling step before performing the sensitivity analysis. We propose the use of the joint modeling approach, i.e., modeling simultaneously the mean and the dispersion of the code outputs using two interlinked generalized linear models (GLMs) or generalized additive models (GAMs). The 'mean model' allows to estimate the sensitivity indices of each scalar model inputs, while the 'dispersion model' allows to derive the total sensitivity index of the functional model inputs. The proposed approach is compared to some classical sensitivity analysis methodologies on an analytical function. Lastly, the new methodology is applied to an industrial computer code that simulates the nuclear fuel irradiation.

  15. Population structure analysis using rare and common functional variants

    Directory of Open Access Journals (Sweden)

    Ding Lili

    2011-11-01

    Full Text Available Abstract Next-generation sequencing technologies now make it possible to genotype and measure hundreds of thousands of rare genetic variations in individuals across the genome. Characterization of high-density genetic variation facilitates control of population genetic structure on a finer scale before large-scale genotyping in disease genetics studies. Population structure is a well-known, prevalent, and important factor in common variant genetic studies, but its relevance in rare variants is unclear. We perform an extensive population structure analysis using common and rare functional variants from the Genetic Analysis Workshop 17 mini-exome sequence. The analysis based on common functional variants required 388 principal components to account for 90% of the variation in population structure. However, an analysis based on rare variants required 532 significant principal components to account for similar levels of variation. Using rare variants, we detected fine-scale substructure beyond the population structure identified using common functional variants. Our results show that the level of population structure embedded in rare variant data is different from the level embedded in common variant data and that correcting for population structure is only as good as the level one wishes to correct.

  16. Genre Analysis in the Frame of Systemic Functional Linguistics

    Directory of Open Access Journals (Sweden)

    Najih Imtihani

    2012-08-01

    Full Text Available Systemic Functional Linguistics is a linguistics approach which cop-siders not only the structure of the language but also its social context. In the Systemic Functional Linguistics the concept of genre is defined as a step-by-step activity to reach the goal. The concept of genre is used to describe the cultural context in a language. According to this view, text should be seen and observed in its interaction with the context and social background. For that, the genre analysis will constantly involve the linguistic social context in the forms of field, tenor, mode, schematic structure and its realization in the text.

  17. Analyzing availability using transfer function models and cross spectral analysis

    International Nuclear Information System (INIS)

    Singpurwalla, N.D.

    1980-01-01

    The paper shows how the methods of multivariate time series analysis can be used in a novel way to investigate the interrelationships between a series of operating (running) times and a series of maintenance (down) times of a complex system. Specifically, the techniques of cross spectral analysis are used to help obtain a Box-Jenkins type transfer function model for the running times and the down times of a nuclear reactor. A knowledge of the interrelationships between the running times and the down times is useful for an evaluation of maintenance policies, for replacement policy decisions, and for evaluating the availability and the readiness of complex systems

  18. Analysis of diagnostic calorimeter data by the transfer function technique

    Energy Technology Data Exchange (ETDEWEB)

    Delogu, R. S., E-mail: rita.delogu@igi.cnr.it; Pimazzoni, A.; Serianni, G. [Consorzio RFX, Corso Stati Uniti, 35127 Padova (Italy); Poggi, C.; Rossi, G. [Università degli Studi di Padova, Via 8 Febbraio 1848, 35122 Padova (Italy)

    2016-02-15

    This paper describes the analysis procedure applied to the thermal measurements on the rear side of a carbon fibre composite calorimeter with the purpose of reconstructing the energy flux due to an ion beam colliding on the front side. The method is based on the transfer function technique and allows a fast analysis by means of the fast Fourier transform algorithm. Its efficacy has been tested both on simulated and measured temperature profiles: in all cases, the energy flux features are well reproduced and beamlets are well resolved. Limits and restrictions of the method are also discussed, providing strategies to handle issues related to signal noise and digital processing.

  19. Automated reasoning applications to design validation and sneak function analysis

    International Nuclear Information System (INIS)

    Stratton, R.C.

    1984-01-01

    Argonne National Laboratory (ANL) is actively involved in the LMFBR Man-Machine Integration (MMI) Safety Program. The objective of this program is to enhance the operational safety and reliability of fast-breeder reactors by optimum integration of men and machines through the application of human factors principles and control engineering to the design, operation, and the control environment. ANL is developing methods to apply automated reasoning and computerization in the validation and sneak function analysis process. This project provides the element definitions and relations necessary for an automated reasoner (AR) to reason about design validation and sneak function analysis. This project also provides a demonstration of this AR application on an Experimental Breeder Reactor-II (EBR-II) system, the Argonne Cooling System

  20. Functional Analysis Of A Selected Airport’s System

    Directory of Open Access Journals (Sweden)

    Dudek Ewa

    2015-11-01

    Full Text Available In this paper two selected airport’s systems (Flight Information System and Public Address Voice Annunciation are defined and described. Then they are used to create an integrated unit, with the presentation of its way of functioning and a schematic picture. The author names main purposes of the integration process, serving to counteract negative consequences arising from implementation of the increasing number of systems on transport objects. In the following part of the article functional analysis of the integrated unit is carried out, defining system’s possible states of work and relations between them. Utilization of mathematical apparatus allows to calculate probabilities of system staying in the respective states, as well as system’s time indexes. Presented results are a fundament for the further analysis of this matter.

  1. Linking Design to Business Strategy Through Functional Analysis

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    1997-01-01

    The paper discusses how designers, conducting design projects in specific organization's, can assure that the design of IT is appropriately linked to the organizations overall business strategy. A case study is presented in the form of a design project in a small public organization. Functional...... analysis was used as a means to clarify how a specific needed information system could support the organization's new business strategy. Using functional analysis in the design project had a powerful effect: it seriously challenged the organization's business strategy and revealed that the system...... to the relation between an organization's IT-projects and its business strategy and by suggesting that it is the responsibility of the designers, conducting design projects, to assure that this task is taken proper care of. Practical guidelines for this purpose are given....

  2. Semantic Analysis of Verbal Collocations with Lexical Functions

    CERN Document Server

    Gelbukh, Alexander

    2013-01-01

    This book is written for both linguists and computer scientists working in the field of artificial intelligence as well as to anyone interested in intelligent text processing. Lexical function is a concept that formalizes semantic and syntactic relations between lexical units. Collocational relation is a type of institutionalized lexical relations which holds between the base and its partner in a collocation. Knowledge of collocation is important for natural language processing because collocation comprises the restrictions on how words can be used together. The book shows how collocations can be annotated with lexical functions in a computer readable dictionary - allowing their precise semantic analysis in texts and their effective use in natural language applications including parsers, high quality machine translation, periphrasis system and computer-aided learning of lexica. The books shows how to extract collocations from corpora and annotate them with lexical functions automatically. To train algorithms,...

  3. Family Functioning and Adolescent Alcohol Use: A Moderated Mediation Analysis

    Science.gov (United States)

    Ohannessian, Christine McCauley; Flannery, Kaitlin M.; Simpson, Emily; Russell, Beth S.

    2016-01-01

    The primary goals of this longitudinal study were to examine the relationship between family functioning and adolescent alcohol use and to examine whether depressed mood mediates this relationship. An additional goal was to explore whether these relations were moderated by gender. The sample included 1,031 high school students from the Mid-Atlantic United States. Participants completed surveys in school during the spring of 2007, 2008, and 2009. Path analysis results indicated that family functioning predicted alcohol use for girls. Moreover, depressed mood mediated this relationship. None of the direct paths between family functioning and adolescent alcohol use were significant for boys. However, similar to girls, depressed mood negatively predicted alcohol use for boys. Taken together, the findings highlight the need for prevention programs targeting adolescent substance use to consider gender-specific trajectories. PMID:26994346

  4. Performance analysis, quality function deployment and structured methods

    Science.gov (United States)

    Maier, M. W.

    Quality function deployment, (QFD), an approach to synthesizing several elements of system modeling and design into a single unit, is presented. Behavioral, physical, and performance modeling are usually considered as separate aspects of system design without explicit linkages. Structured methodologies have developed linkages between behavioral and physical models before, but have not considered the integration of performance models. QFD integrates performance models with traditional structured models. In this method, performance requirements such as cost, weight, and detection range are partitioned into matrices. Partitioning is done by developing a performance model, preferably quantitative, for each requirement. The parameters of the model become the engineering objectives in a QFD analysis and the models are embedded in a spreadsheet version of the traditional QFD matrices. The performance model and its parameters are used to derive part of the functional model by recognizing that a given performance model implies some structure to the functionality of the system.

  5. Computer assisted functional analysis. Computer gestuetzte funktionelle Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, H A.E.; Roesler, H

    1982-01-01

    The latest developments in computer-assisted functional analysis (CFA) in nuclear medicine are presented in about 250 papers of the 19th international annual meeting of the Society of Nuclear Medicine (Bern, September 1981). Apart from the mathematical and instrumental aspects of CFA, computerized emission tomography is given particular attention. Advances in nuclear medical diagnosis in the fields of radiopharmaceuticals, cardiology, angiology, neurology, ophthalmology, pulmonology, gastroenterology, nephrology, endocrinology, oncology and osteology are discussed.

  6. A functional data analysis approach for genetic association studies

    OpenAIRE

    Reimherr, Matthew; Nicolae, Dan

    2014-01-01

    We present a new method based on Functional Data Analysis (FDA) for detecting associations between one or more scalar covariates and a longitudinal response, while correcting for other variables. Our methods exploit the temporal structure of longitudinal data in ways that are otherwise difficult with a multivariate approach. Our procedure, from an FDA perspective, is a departure from more established methods in two key aspects. First, the raw longitudinal phenotypes are assembled into functio...

  7. Phylotyping and functional analysis of two ancient human microbiomes.

    Directory of Open Access Journals (Sweden)

    Raúl Y Tito

    Full Text Available BACKGROUND: The Human Microbiome Project (HMP is one of the U.S. National Institutes of Health Roadmap for Medical Research. Primary interests of the HMP include the distinctiveness of different gut microbiomes, the factors influencing microbiome diversity, and the functional redundancies of the members of human microbiotas. In this present work, we contribute to these interests by characterizing two extinct human microbiotas. METHODOLOGY/PRINCIPAL FINDINGS: We examine two paleofecal samples originating from cave deposits in Durango Mexico and dating to approximately 1300 years ago. Contamination control is a serious issue in ancient DNA research; we use a novel approach to control contamination. After we determined that each sample originated from a different human, we generated 45 thousand shotgun DNA sequencing reads. The phylotyping and functional analysis of these reads reveals a signature consistent with the modern gut ecology. Interestingly, inter-individual variability for phenotypes but not functional pathways was observed. The two ancient samples have more similar functional profiles to each other than to a recently published profile for modern humans. This similarity could not be explained by a chance sampling of the databases. CONCLUSIONS/SIGNIFICANCE: We conduct a phylotyping and functional analysis of ancient human microbiomes, while providing novel methods to control for DNA contamination and novel hypotheses about past microbiome biogeography. We postulate that natural selection has more of an influence on microbiome functional profiles than it does on the species represented in the microbial ecology. We propose that human microbiomes were more geographically structured during pre-Columbian times than today.

  8. Phylogenomic and functional domain analysis of polyketide synthases in Fusarium

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Daren W.; Butchko, Robert A.; Baker, Scott E.; Proctor, Robert H.

    2012-02-01

    Fusarium species are ubiquitous in nature, cause a range of plant diseases, and produce a variety of chemicals often referred to as secondary metabolites. Although some fungal secondary metabolites affect plant growth or protect plants from other fungi and bacteria, their presence in grain based food and feed is more often associated with a variety of diseases in plants and in animals. Many of these structurally diverse metabolites are derived from a family of related enzymes called polyketide synthases (PKSs). A search of genomic sequence of Fusarium verticillioides, F. graminearum, F. oxysporum and Nectria haematococca (anamorph F. solani) identified a total of 58 PKS genes. To gain insight into how this gene family evolved and to guide future studies, we conducted a phylogenomic and functional domain analysis. The resulting genealogy suggested that Fusarium PKSs represent 34 different groups responsible for synthesis of different core metabolites. The analyses indicate that variation in the Fusarium PKS gene family is due to gene duplication and loss events as well as enzyme gain-of-function due to the acquisition of new domains or of loss-of-function due to nucleotide mutations. Transcriptional analysis indicate that the 16 F. verticillioides PKS genes are expressed under a range of conditions, further evidence that they are functional genes that confer the ability to produce secondary metabolites.

  9. Using Operational Analysis to Improve Access to Pulmonary Function Testing

    Directory of Open Access Journals (Sweden)

    Ada Ip

    2016-01-01

    Full Text Available Background. Timely pulmonary function testing is crucial to improving diagnosis and treatment of pulmonary diseases. Perceptions of poor access at an academic pulmonary function laboratory prompted analysis of system demand and capacity to identify factors contributing to poor access. Methods. Surveys and interviews identified stakeholder perspectives on operational processes and access challenges. Retrospective data on testing demand and resource capacity was analyzed to understand utilization of testing resources. Results. Qualitative analysis demonstrated that stakeholder groups had discrepant views on access and capacity in the laboratory. Mean daily resource utilization was 0.64 (SD 0.15, with monthly average utilization consistently less than 0.75. Reserved testing slots for subspecialty clinics were poorly utilized, leaving many testing slots unfilled. When subspecialty demand exceeded number of reserved slots, there was sufficient capacity in the pulmonary function schedule to accommodate added demand. Findings were shared with stakeholders and influenced scheduling process improvements. Conclusion. This study highlights the importance of operational data to identify causes of poor access, guide system decision-making, and determine effects of improvement initiatives in a variety of healthcare settings. Importantly, simple operational analysis can help to improve efficiency of health systems with little or no added financial investment.

  10. Acquisition and analysis strategies in functional MRI at high fields

    International Nuclear Information System (INIS)

    Windischberger, C.

    2001-08-01

    Functional magnetic resonance imaging represents a non-invasive technique to examine neuronal activity in the brain. It applies radio waves to excite nuclear spins, using the emitted signal during relaxation for image generation. Signal modulations from local blood flow and oxygenation level changes caused by neuronal activity are the basis for calculating functional brain maps with high spatial resolution. The present work discusses concepts for improving the spatial and temporal resolution, as well as sophisticated analysis approaches. Besides an exhaustive description of image reconstruction algorithms, computational simulations on echo-shifting in echo-planar imaging are presented and effects on spatial resolution are quantified. The results demonstrate that echo-shifting causes only minimal resolution losses for high signal-to-noise data, but leads to severe resolution degradation (up to 30 %) in images with low signal-to-noise ratios. After an overview of the mechanisms that cause fMRI signal changes subsequent to neuronal activity, explorative analysis algorithms like Fuzzy Cluster Analysis, as well as parametric approaches are described and discussed. In the context of fMRI artifacts, effects of respiratory motion are examined. For the first time, well-defined breathing patterns are used to quantify the influences on fMRI signal intensity. Also, the variability of fMRI activation in a mental rotation paradigm are investigated, using single-trial analysis. Such, intra-subject activation consistency was determined successfully. Finally, in a second study on mental rotation explorative data analysis was applied to retrieve neuro-functional hypotheses. (author)

  11. A Systemic-Functional Analysis of English Language Learners' Writing

    Directory of Open Access Journals (Sweden)

    Luciana C. DE OLIVEIRA

    2015-06-01

    Full Text Available This article presents a systemic-functional linguistic analysis of two writing samples of the University of California Analytical Writing Placement (AWP Examination written by English language learners (ELLs. The analysis shows the linguistic features utilized in the two writing samples, one that received a passing score and one that received a failing score. The article describes some of the grammatical resources which are functional for expository writing, which are divided under three main categories: textual, interpersonal, and ideational resources. Following this brief description is the analysis of both essays in terms of these resources.. The configuration of grammatical features used in the essays make up the detached style of essay 1 and the more personal style of essay 2. These grammatical features include the textual resources of thematic choices and development, clause-combining strategies (connectors, and lexical cohesion; interpersonal resources of interpersonal metaphors of modality; and ideational resources of nominalization and abstractions as ideational metaphors. Implications for educational practice and recommendations for educators based on the analysis are provided.

  12. Discriminant analysis of functional optical topography for schizophrenia diagnosis

    Science.gov (United States)

    Chuang, Ching-Cheng; Nakagome, Kazuyuki; Pu, Shenghong; Lan, Tsuo-Hung; Lee, Chia-Yen; Sun, Chia-Wei

    2014-01-01

    Abnormal prefrontal function plays a central role in the cognition deficits of schizophrenic patients; however, the character of the relationship between discriminant analysis and prefrontal activation remains undetermined. Recently, evidence of low prefrontal cortex (PFC) activation in individuals with schizophrenia has also been found during verbal fluency tests (VFT) and other cognitive tests with several neuroimaging methods. The purpose of this study is to assess the hemodynamic changes of the PFC and discriminant analysis between schizophrenia patients and healthy controls during VFT task by utilizing functional optical topography. A total of 99 subjects including 53 schizophrenic patients and 46 age- and gender-matched healthy controls were studied. The results showed that the healthy group had larger activation in the right and left PFC than in the middle PFC. Besides, the schizophrenic group showed weaker task performance and lower activation in the whole PFC than the healthy group. The result of the discriminant analysis showed a significant difference with P value <0.001 in six channels (CH 23, 29, 31, 40, 42, 52) between the schizophrenic and healthy groups. Finally, 68.69% and 71.72% of subjects are correctly classified as being schizophrenic or healthy with all 52 channels and six significantly different channels, respectively. Our findings suggest that the left PFC can be a feature region for discriminant analysis of schizophrenic diagnosis.

  13. ProbFAST: Probabilistic Functional Analysis System Tool

    Directory of Open Access Journals (Sweden)

    Oliveira Thiago YK

    2010-03-01

    Full Text Available Abstract Background The post-genomic era has brought new challenges regarding the understanding of the organization and function of the human genome. Many of these challenges are centered on the meaning of differential gene regulation under distinct biological conditions and can be performed by analyzing the Multiple Differential Expression (MDE of genes associated with normal and abnormal biological processes. Currently MDE analyses are limited to usual methods of differential expression initially designed for paired analysis. Results We proposed a web platform named ProbFAST for MDE analysis which uses Bayesian inference to identify key genes that are intuitively prioritized by means of probabilities. A simulated study revealed that our method gives a better performance when compared to other approaches and when applied to public expression data, we demonstrated its flexibility to obtain relevant genes biologically associated with normal and abnormal biological processes. Conclusions ProbFAST is a free accessible web-based application that enables MDE analysis on a global scale. It offers an efficient methodological approach for MDE analysis of a set of genes that are turned on and off related to functional information during the evolution of a tumor or tissue differentiation. ProbFAST server can be accessed at http://gdm.fmrp.usp.br/probfast.

  14. ProbFAST: Probabilistic functional analysis system tool.

    Science.gov (United States)

    Silva, Israel T; Vêncio, Ricardo Z N; Oliveira, Thiago Y K; Molfetta, Greice A; Silva, Wilson A

    2010-03-30

    The post-genomic era has brought new challenges regarding the understanding of the organization and function of the human genome. Many of these challenges are centered on the meaning of differential gene regulation under distinct biological conditions and can be performed by analyzing the Multiple Differential Expression (MDE) of genes associated with normal and abnormal biological processes. Currently MDE analyses are limited to usual methods of differential expression initially designed for paired analysis. We proposed a web platform named ProbFAST for MDE analysis which uses Bayesian inference to identify key genes that are intuitively prioritized by means of probabilities. A simulated study revealed that our method gives a better performance when compared to other approaches and when applied to public expression data, we demonstrated its flexibility to obtain relevant genes biologically associated with normal and abnormal biological processes. ProbFAST is a free accessible web-based application that enables MDE analysis on a global scale. It offers an efficient methodological approach for MDE analysis of a set of genes that are turned on and off related to functional information during the evolution of a tumor or tissue differentiation. ProbFAST server can be accessed at http://gdm.fmrp.usp.br/probfast.

  15. Qualitative Functional Decomposition Analysis of Evolved Neuromorphic Flight Controllers

    Directory of Open Access Journals (Sweden)

    Sanjay K. Boddhu

    2012-01-01

    Full Text Available In the previous work, it was demonstrated that one can effectively employ CTRNN-EH (a neuromorphic variant of EH method methodology to evolve neuromorphic flight controllers for a flapping wing robot. This paper describes a novel frequency grouping-based analysis technique, developed to qualitatively decompose the evolved controllers into explainable functional control blocks. A summary of the previous work related to evolving flight controllers for two categories of the controller types, called autonomous and nonautonomous controllers, is provided, and the applicability of the newly developed decomposition analysis for both controller categories is demonstrated. Further, the paper concludes with appropriate discussion of ongoing work and implications for possible future work related to employing the CTRNN-EH methodology and the decomposition analysis techniques presented in this paper.

  16. Analysis of room transfer function and reverberant signal statistics

    DEFF Research Database (Denmark)

    Georganti, Eleftheria; Mourjopoulos, John; Jacobsen, Finn

    2008-01-01

    For some time now, statistical analysis has been a valuable tool in analyzing room transfer functions (RTFs). This work examines existing statistical time-frequency models and techniques for RTF analysis (e.g., Schroeder's stochastic model and the standard deviation over frequency bands for the RTF...... magnitude and phase). RTF fractional octave smoothing, as with 1-slash 3 octave analysis, may lead to RTF simplifications that can be useful for several audio applications, like room compensation, room modeling, auralisation purposes. The aim of this work is to identify the relationship of optimal response...... and the corresponding ratio of the direct and reverberant signal. In addition, this work examines the statistical quantities for speech and audio signals prior to their reproduction within rooms and when recorded in rooms. Histograms and other statistical distributions are used to compare RTF minima of typical...

  17. Hepatic mitochondrial function analysis using needle liver biopsy samples.

    Directory of Open Access Journals (Sweden)

    Michael J J Chu

    Full Text Available BACKGROUNDS AND AIM: Current assessment of pre-operative liver function relies upon biochemical blood tests and histology but these only indirectly measure liver function. Mitochondrial function (MF analysis allows direct measurement of cellular metabolic function and may provide an additional index of hepatic health. Conventional MF analysis requires substantial tissue samples (>100 mg obtained at open surgery. Here we report a method to assess MF using <3 mg of tissue obtained by a Tru-cut® biopsy needle making it suitable for percutaneous application. METHODS: An 18G Bard® Max-core® biopsy instrument was used to collect samples. The optimal Tru-cut® sample weight, stability in ice-cold University of Wisconsin solution, reproducibility and protocol utility was initially evaluated in Wistar rat livers then confirmed in human samples. MF was measured in saponin-permeabilized samples using high-resolution respirometry. RESULTS: The average mass of a single rat and human liver Tru-cut® biopsy was 5.60±0.30 and 5.16±0.15 mg, respectively (mean; standard error of mean. Two milligram of sample was found the lowest feasible mass for the MF assay. Tissue MF declined after 1 hour of cold storage. Six replicate measurements within rats and humans (n = 6 each showed low coefficient of variation (<10% in measurements of State-III respiration, electron transport chain (ETC capacity and respiratory control ratio (RCR. Ischemic rat and human liver samples consistently showed lower State-III respiration, ETC capacity and RCR, compared to normal perfused liver samples. CONCLUSION: Consistent measurement of liver MF and detection of derangement in a disease state was successfully demonstrated using less than half the tissue from a single Tru-cut® biopsy. Using this technique outpatient assessment of liver MF is now feasible, providing a new assay for the evaluation of hepatic function.

  18. Large-scale functional MRI analysis to accumulate knowledge on brain functions

    International Nuclear Information System (INIS)

    Schwartz, Yannick

    2015-01-01

    How can we accumulate knowledge on brain functions? How can we leverage years of research in functional MRI to analyse finer-grained psychological constructs, and build a comprehensive model of the brain? Researchers usually rely on single studies to delineate brain regions recruited by mental processes. They relate their findings to previous works in an informal way by defining regions of interest from the literature. Meta-analysis approaches provide a more principled way to build upon the literature. This thesis investigates three ways to assemble knowledge using activation maps from a large amount of studies. First, we present an approach that uses jointly two similar fMRI experiments, to better condition an analysis from a statistical standpoint. We show that it is a valuable data-driven alternative to traditional regions of interest analyses, but fails to provide a systematic way to relate studies, and thus does not permit to integrate knowledge on a large scale. Because of the difficulty to associate multiple studies, we resort to using a single dataset sampling a large number of stimuli for our second contribution. This method estimates functional networks associated with functional profiles, where the functional networks are interacting brain regions and the functional profiles are a weighted set of cognitive descriptors. This work successfully yields known brain networks and automatically associates meaningful descriptions. Its limitations lie in the unsupervised nature of this method, which is more difficult to validate, and the use of a single dataset. It however brings the notion of cognitive labels, which is central to our last contribution. Our last contribution presents a method that learns functional atlases by combining several datasets. [Henson 2006] shows that forward inference, i.e. the probability of an activation given a cognitive process, is often not sufficient to conclude on the engagement of brain regions for a cognitive process

  19. Accident Analysis and Barrier Function (AEB) Method. Manual for Incident Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Svenson, Ola [Stockholm Univ. (Sweden). Dept. of Psychology

    2000-02-01

    The Accident Analysis and Barrier Function (AEB) Method models an accident or incident as a series of interactions between human and technical systems. In the sequence of human and technical errors leading to an accident there is, in principle, a possibility to arrest the development between each two successive errors. This can be done by a barrier function which, for example, can stop an operator from making an error. A barrier function can be performed by one or several barrier function systems. To illustrate, a mechanical system, a computer system or another operator can all perform a given barrier function to stop an operator from making an error. The barrier function analysis consists of analysis of suggested improvements, the effectiveness of the improvements, the costs of implementation, probability of implementation, the cost of maintaining the barrier function, the probability that maintenance will be kept up to standards and the generalizability of the suggested improvement. The AEB method is similar to the US method called HPES, but differs from that method in different ways. To exemplify, the AEB method has more emphasis on technical errors than HPES. In contrast to HPES that describes a series of events, the AEB method models only errors. This gives a more focused analysis making it well suited for checking other HPES-type accident analyses. However, the AEB method is a generic and stand-alone method that has been applied in other fields than nuclear power, such as, in traffic accident analyses.

  20. Accident Analysis and Barrier Function (AEB) Method. Manual for Incident Analysis

    International Nuclear Information System (INIS)

    Svenson, Ola

    2000-02-01

    The Accident Analysis and Barrier Function (AEB) Method models an accident or incident as a series of interactions between human and technical systems. In the sequence of human and technical errors leading to an accident there is, in principle, a possibility to arrest the development between each two successive errors. This can be done by a barrier function which, for example, can stop an operator from making an error. A barrier function can be performed by one or several barrier function systems. To illustrate, a mechanical system, a computer system or another operator can all perform a given barrier function to stop an operator from making an error. The barrier function analysis consists of analysis of suggested improvements, the effectiveness of the improvements, the costs of implementation, probability of implementation, the cost of maintaining the barrier function, the probability that maintenance will be kept up to standards and the generalizability of the suggested improvement. The AEB method is similar to the US method called HPES, but differs from that method in different ways. To exemplify, the AEB method has more emphasis on technical errors than HPES. In contrast to HPES that describes a series of events, the AEB method models only errors. This gives a more focused analysis making it well suited for checking other HPES-type accident analyses. However, the AEB method is a generic and stand-alone method that has been applied in other fields than nuclear power, such as, in traffic accident analyses

  1. Frontotemporal Dysfunction in Amyotrophic Lateral Sclerosis: A Discriminant Function Analysis.

    Science.gov (United States)

    Nidos, Andreas; Kasselimis, Dimitrios S; Simos, Panagiotis G; Rentzos, Michael; Alexakis, Theodoros; Zalonis, Ioannis; Zouvelou, Vassiliki; Potagas, Constantin; Evdokimidis, Ioannis; Woolley, Susan C

    2016-01-01

    There is growing evidence for extramotor dysfunction (EMd) in amyotrophic lateral sclerosis (ALS), with a reported prevalence of up to 52%. In the present study, we explore the clinical utility of a brief neuropsychological battery for the investigation of cognitive, behavioral, and language deficits in patients with ALS. Thirty-four consecutive ALS patients aged 44-89 years were tested with a brief neuropsychological battery, including executive, behavioral, and language measures. Patients were initially classified as EMd or non-EMd based on their scores on the frontal assessment battery (FAB). Between-group comparisons revealed significant differences in all measures (p < 0.01). Discriminant analysis resulted in a single canonical function, with all tests serving as significant predictors. This function agreed with the FAB in 13 of 17 patients screened as EMd and identified extramotor deficits in 2 additional patients. Overall sensitivity and specificity estimates against FAB were 88.2%. We stress the importance of discriminant function analysis in clinical neuropsychological assessment and argue that the proposed neuropsychological battery may be of clinical value, especially when the option of extensive and comprehensive neuropsychological testing is limited. The psychometric validity of an ALS-frontotemporal dementia diagnosis using neuropsychological tests is also discussed. © 2015 S. Karger AG, Basel.

  2. Analysis of a Heroin Epidemic Model with Saturated Treatment Function

    Directory of Open Access Journals (Sweden)

    Isaac Mwangi Wangari

    2017-01-01

    Full Text Available A mathematical model is developed that examines how heroin addiction spreads in society. The model is formulated to take into account the treatment of heroin users by incorporating a realistic functional form that “saturates” representing the limited availability of treatment. Bifurcation analysis reveals that the model has an intrinsic backward bifurcation whenever the saturation parameter is larger than a fixed threshold. We are particularly interested in studying the model’s global stability. In the absence of backward bifurcations, Lyapunov functions can often be found and used to prove global stability. However, in the presence of backward bifurcations, such Lyapunov functions may not exist or may be difficult to construct. We make use of the geometric approach to global stability to derive a condition that ensures that the system is globally asymptotically stable. Numerical simulations are also presented to give a more complete representation of the model dynamics. Sensitivity analysis performed by Latin hypercube sampling (LHS suggests that the effective contact rate in the population, the relapse rate of heroin users undergoing treatment, and the extent of saturation of heroin users are mechanisms fuelling heroin epidemic proliferation.

  3. Functional complexity of the axonal growth cone: a proteomic analysis.

    Directory of Open Access Journals (Sweden)

    Adriana Estrada-Bernal

    Full Text Available The growth cone, the tip of the emerging neurite, plays a crucial role in establishing the wiring of the developing nervous system. We performed an extensive proteomic analysis of axonal growth cones isolated from the brains of fetal Sprague-Dawley rats. Approximately 2000 proteins were identified at ≥ 99% confidence level. Using informatics, including functional annotation cluster and KEGG pathway analysis, we found great diversity of proteins involved in axonal pathfinding, cytoskeletal remodeling, vesicular traffic and carbohydrate metabolism, as expected. We also found a large and complex array of proteins involved in translation, protein folding, posttranslational processing, and proteasome/ubiquitination-dependent degradation. Immunofluorescence studies performed on hippocampal neurons in culture confirmed the presence in the axonal growth cone of proteins representative of these processes. These analyses also provide evidence for rough endoplasmic reticulum and reveal a reticular structure equipped with Golgi-like functions in the axonal growth cone. Furthermore, Western blot revealed the growth cone enrichment, relative to fetal brain homogenate, of some of the proteins involved in protein synthesis, folding and catabolism. Our study provides a resource for further research and amplifies the relatively recently developed concept that the axonal growth cone is equipped with proteins capable of performing a highly diverse range of functions.

  4. Functional analysis-based interventions for challenging behaviour in dementia.

    Science.gov (United States)

    Moniz Cook, Esme D; Swift, Katie; James, Ian; Malouf, Reem; De Vugt, Marjolein; Verhey, Frans

    2012-02-15

    Functional analysis (FA) for the management of challenging behaviour is a promising behavioural intervention that involves exploring the meaning or purpose of an individual's behaviour. It extends the 'ABC' approach of behavioural analysis, to overcome the restriction of having to derive a single explanatory hypothesis for the person's behaviour. It is seen as a first line alternative to traditional pharmacological management for agitation and aggression. FA typically requires the therapist to develop and evaluate hypotheses-driven strategies that aid family and staff caregivers to reduce or resolve a person's distress and its associated behavioural manifestations. To assess the effects of functional analysis-based interventions for people with dementia (and their caregivers) living in their own home or in other settings. We searched ALOIS: the Cochrane Dementia and Cognitive Improvement Group's Specialized Register on 3 March 2011 using the terms: FA, behaviour (intervention, management, modification), BPSD, psychosocial and Dementia. Randomised controlled trials (RCTs) with reported behavioural outcomes that could be associated with functional analysis for the management of challenging behaviour in dementia. Four reviewers selected trials for inclusion. Two reviewers worked independently to extract data and assess trial quality, including bias. Meta-analyses for reported incidence, frequency, severity of care recipient challenging behaviour and mood (primary outcomes) and caregiver reaction, burden and mood were performed. Details of adverse effects were noted. Eighteen trials are included in the review. The majority were in family care settings. For fourteen studies, FA was just one aspect of a broad multi-component programme of care. Assessing the effect of FA was compromised by ill-defined protocols for the duration of component parts of these programmes (i.e. frequency of the intervention or actual time spent). Therefore, establishing the real effect of the

  5. Comparative thermal buckling analysis of functionally graded plate

    Directory of Open Access Journals (Sweden)

    Čukanović Dragan V.

    2017-01-01

    Full Text Available A thermal buckling analysis of functionally graded thick rectangular plates accord¬ing to von Karman non-linear theory is presented. The material properties of the functionally graded plate, except for the Poisson’s ratio, were assumed to be graded in the thickness direction, according to a power-law distribution, in terms of the volume fractions of the metal and ceramic constituents. Formulations of equilibrium and stability equations are derived using the high order shear deformation theory based on different types of shape functions. Analytical method for determination of the critical buckling temperature for uniform increase of temperature, linear and non-linear change of temperature across thickness of a plate is developed. Numeri¬cal results were obtained in МATLAB software using combinations of symbolic and numeric values. The paper presents comparative results of critical buckling tempera¬ture for different types of shape functions. The accuracy of the formulation presented is verified by comparing to results available from the literature.

  6. The identification of functional motifs in temporal gene expression analysis

    Directory of Open Access Journals (Sweden)

    Michael G. Surette

    2005-01-01

    Full Text Available The identification of transcription factor binding sites is essential to the understanding of the regulation of gene expression and the reconstruction of genetic regulatory networks. The in silico identification of cis-regulatory motifs is challenging due to sequence variability and lack of sufficient data to generate consensus motifs that are of quantitative or even qualitative predictive value. To determine functional motifs in gene expression, we propose a strategy to adopt false discovery rate (FDR and estimate motif effects to evaluate combinatorial analysis of motif candidates and temporal gene expression data. The method decreases the number of predicted motifs, which can then be confirmed by genetic analysis. To assess the method we used simulated motif/expression data to evaluate parameters. We applied this approach to experimental data for a group of iron responsive genes in Salmonella typhimurium 14028S. The method identified known and potentially new ferric-uptake regulator (Fur binding sites. In addition, we identified uncharacterized functional motif candidates that correlated with specific patterns of expression. A SAS code for the simulation and analysis gene expression data is available from the first author upon request.

  7. Metabolomics and Cheminformatics Analysis of Antifungal Function of Plant Metabolites.

    Science.gov (United States)

    Cuperlovic-Culf, Miroslava; Rajagopalan, NandhaKishore; Tulpan, Dan; Loewen, Michele C

    2016-09-30

    Fusarium head blight (FHB), primarily caused by Fusarium graminearum , is a devastating disease of wheat. Partial resistance to FHB of several wheat cultivars includes specific metabolic responses to inoculation. Previously published studies have determined major metabolic changes induced by pathogens in resistant and susceptible plants. Functionality of the majority of these metabolites in resistance remains unknown. In this work we have made a compilation of all metabolites determined as selectively accumulated following FHB inoculation in resistant plants. Characteristics, as well as possible functions and targets of these metabolites, are investigated using cheminformatics approaches with focus on the likelihood of these metabolites acting as drug-like molecules against fungal pathogens. Results of computational analyses of binding properties of several representative metabolites to homology models of fungal proteins are presented. Theoretical analysis highlights the possibility for strong inhibitory activity of several metabolites against some major proteins in Fusarium graminearum , such as carbonic anhydrases and cytochrome P450s. Activity of several of these compounds has been experimentally confirmed in fungal growth inhibition assays. Analysis of anti-fungal properties of plant metabolites can lead to the development of more resistant wheat varieties while showing novel application of cheminformatics approaches in the analysis of plant/pathogen interactions.

  8. Global sensitivity analysis using a Gaussian Radial Basis Function metamodel

    International Nuclear Information System (INIS)

    Wu, Zeping; Wang, Donghui; Okolo N, Patrick; Hu, Fan; Zhang, Weihua

    2016-01-01

    Sensitivity analysis plays an important role in exploring the actual impact of adjustable parameters on response variables. Amongst the wide range of documented studies on sensitivity measures and analysis, Sobol' indices have received greater portion of attention due to the fact that they can provide accurate information for most models. In this paper, a novel analytical expression to compute the Sobol' indices is derived by introducing a method which uses the Gaussian Radial Basis Function to build metamodels of computationally expensive computer codes. Performance of the proposed method is validated against various analytical functions and also a structural simulation scenario. Results demonstrate that the proposed method is an efficient approach, requiring a computational cost of one to two orders of magnitude less when compared to the traditional Quasi Monte Carlo-based evaluation of Sobol' indices. - Highlights: • RBF based sensitivity analysis method is proposed. • Sobol' decomposition of Gaussian RBF metamodel is obtained. • Sobol' indices of Gaussian RBF metamodel are derived based on the decomposition. • The efficiency of proposed method is validated by some numerical examples.

  9. Waste encapsulation and storage facility function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate Waste Encapsulation and Storage Facility (WESF)

  10. 300 Area fuel supply facilities deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate the 300 Area Fuel Supply Facilities

  11. Sensitivity functions for uncertainty analysis: Sensitivity and uncertainty analysis of reactor performance parameters

    International Nuclear Information System (INIS)

    Greenspan, E.

    1982-01-01

    This chapter presents the mathematical basis for sensitivity functions, discusses their physical meaning and information they contain, and clarifies a number of issues concerning their application, including the definition of group sensitivities, the selection of sensitivity functions to be included in the analysis, and limitations of sensitivity theory. Examines the theoretical foundation; criticality reset sensitivities; group sensitivities and uncertainties; selection of sensitivities included in the analysis; and other uses and limitations of sensitivity functions. Gives the theoretical formulation of sensitivity functions pertaining to ''as-built'' designs for performance parameters of the form of ratios of linear flux functionals (such as reaction-rate ratios), linear adjoint functionals, bilinear functions (such as reactivity worth ratios), and for reactor reactivity. Offers a consistent procedure for reducing energy-dependent or fine-group sensitivities and uncertainties to broad group sensitivities and uncertainties. Provides illustrations of sensitivity functions as well as references to available compilations of such functions and of total sensitivities. Indicates limitations of sensitivity theory originating from the fact that this theory is based on a first-order perturbation theory

  12. Phylogenetic comparative methods complement discriminant function analysis in ecomorphology.

    Science.gov (United States)

    Barr, W Andrew; Scott, Robert S

    2014-04-01

    In ecomorphology, Discriminant Function Analysis (DFA) has been used as evidence for the presence of functional links between morphometric variables and ecological categories. Here we conduct simulations of characters containing phylogenetic signal to explore the performance of DFA under a variety of conditions. Characters were simulated using a phylogeny of extant antelope species from known habitats. Characters were modeled with no biomechanical relationship to the habitat category; the only sources of variation were body mass, phylogenetic signal, or random "noise." DFA on the discriminability of habitat categories was performed using subsets of the simulated characters, and Phylogenetic Generalized Least Squares (PGLS) was performed for each character. Analyses were repeated with randomized habitat assignments. When simulated characters lacked phylogenetic signal and/or habitat assignments were random, ecomorphology. Copyright © 2013 Wiley Periodicals, Inc.

  13. Analysis of viscoplastic plates with material degradation using influence functions

    International Nuclear Information System (INIS)

    Fotiu, P.; Irschik, H.

    1987-01-01

    Influence functions are well-known from the computational analysis of linear elastic plates. For inelastic plates, unfortunately, this convenient Green's function method does not apply in its classical sense, because superposition of imposed loadings is not possible. However, following a complete elastic-inelastic analogy for small deflections of beams and plates, the inelastic part of strain may be treated as an additional source of self-stress in the linear elastic structure with fixed (initial) stiffness. Hence, the inelastic plate is analogous to the linear elastic one, but subjected to the imposed loadings as well as to fictitious additional sources of self-stress, likewise to a given thermal loading. (orig./GL)

  14. GeoChips for Analysis of Microbial Functional Communities

    Energy Technology Data Exchange (ETDEWEB)

    Van Nostrand, Joy D.; Wu, Liyou; He, Zhili; Zhou, Jizhong

    2008-09-30

    Functional gene arrays (FGA) are microarrays that contain probes for genes encoding proteins or enzymes involved in functions of interest and allow for the study of thousands of genes at one time. The most comprehensive FGA to date is the GeoChip, which contains ~;;24,000 probes for ~;;10,000 genes involved in the geochemical cycling of C, N, P, and S, as well as genes involved in metal resistance and reduction and contaminant degradation. This chapter details the methods necessary for GeoChip analysis. Methods covered include preparation of DNA (whole community genome amplification and labeling), array setup (prehybridization steps), hybridization (sample and hybridization buffers), and post hybridization steps (slide washing and array scanning).

  15. Application of generalized function to dynamic analysis of thick plates

    International Nuclear Information System (INIS)

    Zheng, D.; Weng, Z.

    1987-01-01

    The structures with thick plates have been used extensively in national defence, mechanical engineering, chemical engineering, nuclear engineering, civil engineering, etc.. Various theories have been established to deal with the problems of elastic plates, which include the classical theory of thin plates, the improved theory of thick plates, three-dimensional elastical theory. In this paper, the derivative of δ-function is handled by using the generalized function. The dynamic analysis of thick plates subjected the concentrated load is presented. The improved Donnell's equation of thick plates is deduced and employed as the basic equation. The generalized coordinates are solved by using the method of MWR. The general expressions for the dynamic response of elastic thick plates subjected the concentrated load are given. The numerical results for rectangular plates are given herein. The results are compared with those obtained from the improved theory and the classical theory of plates. (orig./GL)

  16. Uncertainty Analysis via Failure Domain Characterization: Unrestricted Requirement Functions

    Science.gov (United States)

    Crespo, Luis G.; Kenny, Sean P.; Giesy, Daniel P.

    2011-01-01

    This paper proposes an uncertainty analysis framework based on the characterization of the uncertain parameter space. This characterization enables the identification of worst-case uncertainty combinations and the approximation of the failure and safe domains with a high level of accuracy. Because these approximations are comprised of subsets of readily computable probability, they enable the calculation of arbitrarily tight upper and lower bounds to the failure probability. The methods developed herein, which are based on nonlinear constrained optimization, are applicable to requirement functions whose functional dependency on the uncertainty is arbitrary and whose explicit form may even be unknown. Some of the most prominent features of the methodology are the substantial desensitization of the calculations from the assumed uncertainty model (i.e., the probability distribution describing the uncertainty) as well as the accommodation for changes in such a model with a practically insignificant amount of computational effort.

  17. Semigroups of analytic functions in analysis and applications

    International Nuclear Information System (INIS)

    Goryainov, Victor V

    2012-01-01

    This survey considers problems of analysis and certain related areas in which semigroups of analytic functions with respect to the operation of composition appear naturally. The main attention is devoted to holomorphic maps of a disk (or a half-plane) into itself. The role of fixed points is highlighted, both in the description of the structure of semigroups and in applications. Interconnections of the problem of fractional iteration with certain problems in the theory of random branching processes are pointed out, as well as with certain questions of non-commutative probability. The role of the infinitesimal description of semigroups of conformal maps in the development of the parametric method in the theory of univalent functions is shown. Bibliography: 94 titles.

  18. Uncertainty Analysis via Failure Domain Characterization: Polynomial Requirement Functions

    Science.gov (United States)

    Crespo, Luis G.; Munoz, Cesar A.; Narkawicz, Anthony J.; Kenny, Sean P.; Giesy, Daniel P.

    2011-01-01

    This paper proposes an uncertainty analysis framework based on the characterization of the uncertain parameter space. This characterization enables the identification of worst-case uncertainty combinations and the approximation of the failure and safe domains with a high level of accuracy. Because these approximations are comprised of subsets of readily computable probability, they enable the calculation of arbitrarily tight upper and lower bounds to the failure probability. A Bernstein expansion approach is used to size hyper-rectangular subsets while a sum of squares programming approach is used to size quasi-ellipsoidal subsets. These methods are applicable to requirement functions whose functional dependency on the uncertainty is a known polynomial. Some of the most prominent features of the methodology are the substantial desensitization of the calculations from the uncertainty model assumed (i.e., the probability distribution describing the uncertainty) as well as the accommodation for changes in such a model with a practically insignificant amount of computational effort.

  19. Advanced functional network analysis in the geosciences: The pyunicorn package

    Science.gov (United States)

    Donges, Jonathan F.; Heitzig, Jobst; Runge, Jakob; Schultz, Hanna C. H.; Wiedermann, Marc; Zech, Alraune; Feldhoff, Jan; Rheinwalt, Aljoscha; Kutza, Hannes; Radebach, Alexander; Marwan, Norbert; Kurths, Jürgen

    2013-04-01

    Functional networks are a powerful tool for analyzing large geoscientific datasets such as global fields of climate time series originating from observations or model simulations. pyunicorn (pythonic unified complex network and recurrence analysis toolbox) is an open-source, fully object-oriented and easily parallelizable package written in the language Python. It allows for constructing functional networks (aka climate networks) representing the structure of statistical interrelationships in large datasets and, subsequently, investigating this structure using advanced methods of complex network theory such as measures for networks of interacting networks, node-weighted statistics or network surrogates. Additionally, pyunicorn allows to study the complex dynamics of geoscientific systems as recorded by time series by means of recurrence networks and visibility graphs. The range of possible applications of the package is outlined drawing on several examples from climatology.

  20. DNA mimic proteins: functions, structures, and bioinformatic analysis.

    Science.gov (United States)

    Wang, Hao-Ching; Ho, Chun-Han; Hsu, Kai-Cheng; Yang, Jinn-Moon; Wang, Andrew H-J

    2014-05-13

    DNA mimic proteins have DNA-like negative surface charge distributions, and they function by occupying the DNA binding sites of DNA binding proteins to prevent these sites from being accessed by DNA. DNA mimic proteins control the activities of a variety of DNA binding proteins and are involved in a wide range of cellular mechanisms such as chromatin assembly, DNA repair, transcription regulation, and gene recombination. However, the sequences and structures of DNA mimic proteins are diverse, making them difficult to predict by bioinformatic search. To date, only a few DNA mimic proteins have been reported. These DNA mimics were not found by searching for functional motifs in their sequences but were revealed only by structural analysis of their charge distribution. This review highlights the biological roles and structures of 16 reported DNA mimic proteins. We also discuss approaches that might be used to discover new DNA mimic proteins.

  1. Influence of Type of Frequency Weighting Function On VDV Analysis

    Science.gov (United States)

    Kowalska-Koczwara, Alicja; Stypuła, Krzysztof

    2017-10-01

    Transport vibrations are the subject of many research, mostly their influence on structural elements of the building is investigated. However, nowadays, especially in the centres of large cities were apartments, residential buildings are closer to the transport vibration sources, an increasing attention is given to providing vibrational comfort to humans in buildings. Currently, in most countries, two main methods of evaluation are used: root mean squared method (RMS) and vibration dose value (VDV). In this article, VDV method is presented and the analysis of the weighting functions selection on value of VDV is made. Measurements required for the analysis were made in Krakow, on masonry, residential, two storey building located in the city centre. The building is subjected into two transport vibration sources: tram passages and vehicle passages on very close located road. Measurement points were located on the basement wall at ground level to control the excitation and in the middle of the floor on the highest storey (in the place where people percept vibration). The room chosen for measurements is located closest to the transport excitation sources. During the measurements, 25 vibration events were recorded and analysed. VDV values were calculated for three different weighting functions according to standard: ISO 2631-1, ISO 2631-2 and BS-6841. Differences in VDV values are shown, but also influence of the weighting function selection on result of evaluation is also presented. VDV analysis was performed not only for the individual vibration event but also all day and night vibration exposure were calculated using formulas contained in the annex to the standard BS-6841. It is demonstrated that, although there are differences in the values of VDV, an influence on all day and night exposure is no longer so significant.

  2. On uniform resampling and gaze analysis of bidirectional texture functions

    Czech Academy of Sciences Publication Activity Database

    Filip, Jiří; Chantler, M.J.; Haindl, Michal

    2009-01-01

    Roč. 6, č. 3 (2009), s. 1-15 ISSN 1544-3558 R&D Projects: GA MŠk 1M0572; GA ČR GA102/08/0593 Grant - others:EC Marie Curie(BE) 41358 Institutional research plan: CEZ:AV0Z10750506 Keywords : BTF * texture * eye tracking Subject RIV: BD - Theory of Information Impact factor: 1.447, year: 2009 http://library.utia.cas.cz/separaty/2009/RO/haindl-on uniform resampling and gaze analysis of bidirectional texture functions.pdf

  3. Functional analysis and quantum mechanics: an introduction for physicists

    International Nuclear Information System (INIS)

    Ranade, Kedar S.

    2015-01-01

    We give an introduction to certain topics from functional analysis which are relevant for physics in general and in particular for quantum mechanics. Starting from some examples, we discuss the theory of Hilbert spaces, spectral theory of unbounded operators, distributions and their applications and present some facts from operator algebras. We do not give proofs, but present examples and analogies from physics which should be useful to get a feeling for the topics considered. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  4. Functional analysis and quantum mechanics: an introduction for physicists

    Energy Technology Data Exchange (ETDEWEB)

    Ranade, Kedar S. [Ulm Univ. (Germany). Inst. fuer Quantenphysik and Center for Integrated Quantum Science and Technology (IQST)

    2015-09-15

    We give an introduction to certain topics from functional analysis which are relevant for physics in general and in particular for quantum mechanics. Starting from some examples, we discuss the theory of Hilbert spaces, spectral theory of unbounded operators, distributions and their applications and present some facts from operator algebras. We do not give proofs, but present examples and analogies from physics which should be useful to get a feeling for the topics considered. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  5. A Functional Approach to Hyperspectral Image Analysis in the Cloud

    Science.gov (United States)

    Wilson, A.; Lindholm, D. M.; Coddington, O.; Pilewskie, P.

    2017-12-01

    Hyperspectral image volumes are very large. A hyperspectral image analysis (HIA) may use 100TB of data, a huge barrier to their use. Hylatis is a new NASA project to create a toolset for HIA. Through web notebook and cloud technology, Hylatis will provide a more interactive experience for HIA by defining and implementing concepts and operations for HIA, identified and vetted by subject matter experts, and callable within a general purpose language, particularly Python. Hylatis leverages LaTiS, a data access framework developed at LASP. With an OPeNDAP compliant interface plus additional server side capabilities, the LaTiS API provides a uniform interface to virtually any data source, and has been applied to various storage systems, including: file systems, databases, remote servers, and in various domains including: space science, systems administration and stock quotes. In the LaTiS architecture, data `adapters' read data into a data model, where server-side computations occur. Data `writers' write data from the data model into the desired format. The Hylatis difference is the data model. In LaTiS, data are represented as mathematical functions of independent and dependent variables. Domain semantics are not present at this level, but are instead present in higher software layers. The benefit of a domain agnostic, mathematical representation is having the power of math, particularly functional algebra, unconstrained by domain semantics. This agnosticism supports reusable server side functionality applicable in any domain, such as statistical, filtering, or projection operations. Algorithms to aggregate or fuse data can be simpler because domain semantics are separated from the math. Hylatis will map the functional model onto the Spark relational interface, thereby adding a functional interface to that big data engine.This presentation will discuss Hylatis goals, strategies, and current state.

  6. Real analysis foundations and functions of one variable

    CERN Document Server

    Laczkovich, Miklós

    2015-01-01

    Based on courses given at Eötvös Loránd University (Hungary) over the past 30 years, this introductory textbook develops the central concepts of the analysis of functions of one variable - systematically, with many examples and illustrations, and in a manner that builds upon, and sharpens, the students' mathematical intuition. The modular organization of the book makes it adaptable for either semester or year-long introductory courses, while the wealth of material allows for it to be used at various levels of student sophistication in all programs where analysis is a part of the curriculum, including teachers' education. In the spirit of learning-by-doing, Real Analysis includes more than 500 engaging exercises for the student keen on mastering the basics of analysis. There are frequent hints and occasional complete solutions provided for the more challenging exercises making it an ideal choice for independent study. The book includes a solid grounding in the basics of logic and proofs, sets, and real numb...

  7. Utilizing Minkowski functionals for image analysis: a marching square algorithm

    International Nuclear Information System (INIS)

    Mantz, Hubert; Jacobs, Karin; Mecke, Klaus

    2008-01-01

    Comparing noisy experimental image data with statistical models requires a quantitative analysis of grey-scale images beyond mean values and two-point correlations. A real-space image analysis technique is introduced for digitized grey-scale images, based on Minkowski functionals of thresholded patterns. A novel feature of this marching square algorithm is the use of weighted side lengths for pixels, so that boundary lengths are captured accurately. As examples to illustrate the technique we study surface topologies emerging during the dewetting process of thin films and analyse spinodal decomposition as well as turbulent patterns in chemical reaction–diffusion systems. The grey-scale value corresponds to the height of the film or to the concentration of chemicals, respectively. Comparison with analytic calculations in stochastic geometry models reveals a remarkable agreement of the examples with a Gaussian random field. Thus, a statistical test for non-Gaussian features in experimental data becomes possible with this image analysis technique—even for small image sizes. Implementations of the software used for the analysis are offered for download

  8. Analysis of neutron flux measurement systems using statistical functions

    International Nuclear Information System (INIS)

    Pontes, Eduardo Winston

    1997-01-01

    This work develops an integrated analysis for neutron flux measurement systems using the concepts of cumulants and spectra. Its major contribution is the generalization of Campbell's theorem in the form of spectra in the frequency domain, and its application to the analysis of neutron flux measurement systems. Campbell's theorem, in its generalized form, constitutes an important tool, not only to find the nth-order frequency spectra of the radiation detector, but also in the system analysis. The radiation detector, an ionization chamber for neutrons, is modeled for cylindrical, plane and spherical geometries. The detector current pulses are characterized by a vector of random parameters, and the associated charges, statistical moments and frequency spectra of the resulting current are calculated. A computer program is developed for application of the proposed methodology. In order for the analysis to integrate the associated electronics, the signal processor is studied, considering analog and digital configurations. The analysis is unified by developing the concept of equivalent systems that can be used to describe the cumulants and spectra in analog or digital systems. The noise in the signal processor input stage is analysed in terms of second order spectrum. Mathematical expressions are presented for cumulants and spectra up to fourth order, for important cases of filter positioning relative to detector spectra. Unbiased conventional estimators for cumulants are used, and, to evaluate systems precision and response time, expressions are developed for their variances. Finally, some possibilities for obtaining neutron radiation flux as a function of cumulants are discussed. In summary, this work proposes some analysis tools which make possible important decisions in the design of better neutron flux measurement systems. (author)

  9. Diagnostics of subtropical plants functional state by cluster analysis

    Directory of Open Access Journals (Sweden)

    Oksana Belous

    2016-05-01

    Full Text Available The article presents an application example of statistical methods for data analysis on diagnosis of the adaptive capacity of subtropical plants varieties. We depicted selection indicators and basic physiological parameters that were defined as diagnostic. We used evaluation on a set of parameters of water regime, there are: determination of water deficit of the leaves, determining the fractional composition of water and detection parameters of the concentration of cell sap (CCS (for tea culture flushes. These settings are characterized by high liability and high responsiveness to the effects of many abiotic factors that determined the particular care in the selection of plant material for analysis and consideration of the impact on sustainability. On the basis of the experimental data calculated the coefficients of pair correlation between climatic factors and used physiological indicators. The result was a selection of physiological and biochemical indicators proposed to assess the adaptability and included in the basis of methodical recommendations on diagnostics of the functional state of the studied cultures. Analysis of complex studies involving a large number of indicators is quite difficult, especially does not allow to quickly identify the similarity of new varieties for their adaptive responses to adverse factors, and, therefore, to set general requirements to conditions of cultivation. Use of cluster analysis suggests that in the analysis of only quantitative data; define a set of variables used to assess varieties (and the more sampling, the more accurate the clustering will happen, be sure to ascertain the measure of similarity (or difference between objects. It is shown that the identification of diagnostic features, which are subjected to statistical processing, impact the accuracy of the varieties classification. Selection in result of the mono-clusters analysis (variety tea Kolhida; hazelnut Lombardsky red; variety kiwi Monty

  10. Functional morphometric analysis of the furcula in mesozoic birds.

    Directory of Open Access Journals (Sweden)

    Roger A Close

    Full Text Available The furcula displays enormous morphological and structural diversity. Acting as an important origin for flight muscles involved in the downstroke, the form of this element has been shown to vary with flight mode. This study seeks to clarify the strength of this form-function relationship through the use of eigenshape morphometric analysis coupled with recently developed phylogenetic comparative methods (PCMs, including phylogenetic Flexible Discriminant Analysis (pFDA. Additionally, the morphospace derived from the furculae of extant birds is used to shed light on possible flight adaptations of Mesozoic fossil taxa. While broad conclusions of earlier work are supported (U-shaped furculae are associated with soaring, strong anteroposterior curvature with wing-propelled diving, correlations between form and function do not appear to be so clear-cut, likely due to the significantly larger dataset and wider spectrum of flight modes sampled here. Interclavicular angle is an even more powerful discriminator of flight mode than curvature, and is positively correlated with body size. With the exception of the close relatives of modern birds, the ornithuromorphs, Mesozoic taxa tend to occupy unique regions of morphospace, and thus may have either evolved unfamiliar flight styles or have arrived at similar styles through divergent musculoskeletal configurations.

  11. Implicit functions and solution mappings a view from variational analysis

    CERN Document Server

    Dontchev, Asen L

    2014-01-01

    The implicit function theorem is one of the most important theorems in analysis and its many variants are basic tools in partial differential equations and numerical analysis. This second edition of Implicit Functions and Solution Mappings presents an updated and more complete picture of the field by including solutions of problems that have been solved since the first edition was published, and places old and new results in a broader perspective. The purpose of this self-contained work is to provide a reference on the topic and to provide a unified collection of a number of results which are currently scattered throughout the literature. Updates to this edition include new sections in almost all chapters, new exercises and examples, updated commentaries to chapters and an enlarged index and references section. From reviews of the first edition: “The book commences with a helpful context-setting preface followed by six chapters. Each chapter starts with a useful preamble and concludes with a careful and ins...

  12. System diagnostics using qualitative analysis and component functional classification

    International Nuclear Information System (INIS)

    Reifman, J.; Wei, T.Y.C.

    1993-01-01

    A method for detecting and identifying faulty component candidates during off-normal operations of nuclear power plants involves the qualitative analysis of macroscopic imbalances in the conservation equations of mass, energy and momentum in thermal-hydraulic control volumes associated with one or more plant components and the functional classification of components. The qualitative analysis of mass and energy is performed through the associated equations of state, while imbalances in momentum are obtained by tracking mass flow rates which are incorporated into a first knowledge base. The plant components are functionally classified, according to their type, as sources or sinks of mass, energy and momentum, depending upon which of the three balance equations is most strongly affected by a faulty component which is incorporated into a second knowledge base. Information describing the connections among the components of the system forms a third knowledge base. The method is particularly adapted for use in a diagnostic expert system to detect and identify faulty component candidates in the presence of component failures and is not limited to use in a nuclear power plant, but may be used with virtually any type of thermal-hydraulic operating system. 5 figures

  13. Hazard function analysis for flood planning under nonstationarity

    Science.gov (United States)

    Read, Laura K.; Vogel, Richard M.

    2016-05-01

    The field of hazard function analysis (HFA) involves a probabilistic assessment of the "time to failure" or "return period," T, of an event of interest. HFA is used in epidemiology, manufacturing, medicine, actuarial statistics, reliability engineering, economics, and elsewhere. For a stationary process, the probability distribution function (pdf) of the return period always follows an exponential distribution, the same is not true for nonstationary processes. When the process of interest, X, exhibits nonstationary behavior, HFA can provide a complementary approach to risk analysis with analytical tools particularly useful for hydrological applications. After a general introduction to HFA, we describe a new mathematical linkage between the magnitude of the flood event, X, and its return period, T, for nonstationary processes. We derive the probabilistic properties of T for a nonstationary one-parameter exponential model of X, and then use both Monte-Carlo simulation and HFA to generalize the behavior of T when X arises from a nonstationary two-parameter lognormal distribution. For this case, our findings suggest that a two-parameter Weibull distribution provides a reasonable approximation for the pdf of T. We document how HFA can provide an alternative approach to characterize the probabilistic properties of both nonstationary flood series and the resulting pdf of T.

  14. Structural and functional analysis of phytotoxin toxoflavin-degrading enzyme.

    Directory of Open Access Journals (Sweden)

    Woo-Suk Jung

    Full Text Available Pathogenic bacteria synthesize and secrete toxic low molecular weight compounds as virulence factors. These microbial toxins play essential roles in the pathogenicity of bacteria in various hosts, and are emerging as targets for antivirulence strategies. Toxoflavin, a phytotoxin produced by Burkholderia glumae BGR1, has been known to be the key factor in rice grain rot and wilt in many field crops. Recently, toxoflavin-degrading enzyme (TxDE was identified from Paenibacillus polymyxa JH2, thereby providing a possible antivirulence strategy for toxoflavin-mediated plant diseases. Here, we report the crystal structure of TxDE in the substrate-free form and in complex with toxoflavin, along with the results of a functional analysis. The overall structure of TxDE is similar to those of the vicinal oxygen chelate superfamily of metalloenzymes, despite the lack of apparent sequence identity. The active site is located at the end of the hydrophobic channel, 9 Å in length, and contains a Mn(II ion interacting with one histidine residue, two glutamate residues, and three water molecules in an octahedral coordination. In the complex, toxoflavin binds in the hydrophobic active site, specifically the Mn(II-coordination shell by replacing a ligating water molecule. A functional analysis indicated that TxDE catalyzes the degradation of toxoflavin in a manner dependent on oxygen, Mn(II, and the reducing agent dithiothreitol. These results provide the structural features of TxDE and the early events in catalysis.

  15. Evaluation of the Utility of a Discrete-Trial Functional Analysis in Early Intervention Classrooms

    Science.gov (United States)

    Kodak, Tiffany; Fisher, Wayne W.; Paden, Amber; Dickes, Nitasha

    2013-01-01

    We evaluated a discrete-trial functional analysis implemented by regular classroom staff in a classroom setting. The results suggest that the discrete-trial functional analysis identified a social function for each participant and may require fewer staff than standard functional analysis procedures.

  16. Coagulation parameters and platelet function analysis in patients with acromegaly.

    Science.gov (United States)

    Colak, A; Yılmaz, H; Temel, Y; Demirpence, M; Simsek, N; Karademirci, İ; Bozkurt, U; Yasar, E

    2016-01-01

    Acromegaly is associated with increased cardiovascular morbidity and mortality. The data about the evaluation of coagulation and fibrinolysis in acromegalic patients are very limited and to our knowledge, platelet function analysis has never been investigated. So, we aimed to investigate the levels of protein C, protein S, fibrinogen, antithrombin 3 and platelet function analysis in patients with acromegaly. Thirty-nine patients with active acromegaly and 35 healthy subjects were included in the study. Plasma glucose and lipid profile, fibrinogen levels, GH and IGF-1 levels and protein C, protein S and antithrombin III activities were measured in all study subjects. Also, platelet function analysis was evaluated with collagen/ADP and collagen-epinephrine-closure times. Demographic characteristics of the patient and the control were similar. As expected, fasting blood glucose levels and serum GH and IGF-1 levels were significantly higher in the patient group compared with the control group (pglc: 0.002, pGH: 0.006, pIGF-1: 0.001, respectively). But lipid parameters were similar between the two groups. While serum fibrinogen and antithrombin III levels were found to be significantly higher in acromegaly group (p fibrinogen: 0.005 and pantithrombin III: 0.001), protein S and protein C activity values were significantly lower in the patient group (p protein S: 0.001, p protein C: 0.001). Also significantly enhanced platelet function (measured by collagen/ADP- and collagen/epinephrine-closure times) was demonstrated in acromegaly (p col-ADP: 0.002, p col-epinephrine: 0.002). The results did not change, when we excluded six patients with type 2 diabetes in the acromegaly group. There was a negative correlation between serum GH levels and protein S (r: -0.25, p: 0.04)) and protein C (r: -0.26, p: 0.04) values. Likewise, there was a negative correlation between IGF-1 levels and protein C values (r: -0.39, p: 0.002), protein S values (r: -0.39, p: 0.001), collagen

  17. A multivariate analysis of serum nutrient levels and lung function

    Directory of Open Access Journals (Sweden)

    Smit Henriette A

    2008-09-01

    Full Text Available Abstract Background There is mounting evidence that estimates of intakes of a range of dietary nutrients are related to both lung function level and rate of decline, but far less evidence on the relation between lung function and objective measures of serum levels of individual nutrients. The aim of this study was to conduct a comprehensive examination of the independent associations of a wide range of serum markers of nutritional status with lung function, measured as the one-second forced expiratory volume (FEV1. Methods Using data from the Third National Health and Nutrition Examination Survey, a US population-based cross-sectional study, we investigated the relation between 21 serum markers of potentially relevant nutrients and FEV1, with adjustment for potential confounding factors. Systematic approaches were used to guide the analysis. Results In a mutually adjusted model, higher serum levels of antioxidant vitamins (vitamin A, beta-cryptoxanthin, vitamin C, vitamin E, selenium, normalized calcium, chloride, and iron were independently associated with higher levels of FEV1. Higher concentrations of potassium and sodium were associated with lower FEV1. Conclusion Maintaining higher serum concentrations of dietary antioxidant vitamins and selenium is potentially beneficial to lung health. In addition other novel associations found in this study merit further investigation.

  18. Analysis of selected reservoirs functioning in the Wielkopolska region

    Directory of Open Access Journals (Sweden)

    Mariusz Sojka

    2017-12-01

    Full Text Available The paper presents the problems related to the functioning of reservoirs in the Wielkopolska province and suggests their possible solutions. The reservoirs chosen as examples include typical dam constructions with a single water body (Jeziorsko, Rydzyna, two water body objects with separated preliminary part (Stare Miasto, Kowalskie, Radzyny and lateral constructions (Pakosław, Jutrosin. The reservoirs were built in period from 1970 to 2014. They differ in construction, functions and water management rules. Analysis of the main problems related to the reservoir functioning is aimed at finding ways of improving the construction of new reservoirs that would satisfy increasingly stringent environmental and legal restrictions and the methods of water management in the reservoirs. On the basis of a questionnaire filled in by the reservoir operators, the main problem is water quality. Especially the huge inflow of biogenic compounds causes blooms of algae and overgrowth with riparian vegetation. Some difficulties are also related to management of the reservoirs of multi-purpose operation. It is difficult to take into account the requirements of environmental flow maintenance, flood protection, water supply for agriculture and water use for tourism and recreation and hydropower generation, etc.

  19. ANALYSIS OF STUDENTS’ LEARNING OBSTACLES ON LEARNING INVERS FUNCTION MATERIAL

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    Krisna Satrio Perbowo

    2017-09-01

    Full Text Available This research is based on the presence of obstacle in learning mathematics on inverse function. This research aims to analyze the learning obstacle, to know the types of error that is suffered by the students in learning inverse function. Kind of this kualitative research descriptive with data triangulation. The research subjects are high school students which is contained of 74 students and was taken 6 students to be main sample. The data of students’ error is obtained from the writen test result, the students’ false answers are identified into the type of error. Then it was chosen several students to be interviewed. Which the analysis result finding data in this research showed there are 4 types of errors, which are concept error, procedure error, counting error and concluding error. An obstacle which appear in learning inverse function is influenced by two factors, i.e internal factor and eksternal factor. Internal factor is showed by the students’ motivation in following learning and students’ skill in receiving learning material. While the eksternal factor is showed by the curriculum which applied in school with acceleration class caused many narrow learning time, teaching materials that is less complete with the discussion of question sample.

  20. Library of sophisticated functions for analysis of nuclear spectra

    Science.gov (United States)

    Morháč, Miroslav; Matoušek, Vladislav

    2009-10-01

    In the paper we present compact library for analysis of nuclear spectra. The library consists of sophisticated functions for background elimination, smoothing, peak searching, deconvolution, and peak fitting. The functions can process one- and two-dimensional spectra. The software described in the paper comprises a number of conventional as well as newly developed methods needed to analyze experimental data. Program summaryProgram title: SpecAnalysLib 1.1 Catalogue identifier: AEDZ_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEDZ_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 42 154 No. of bytes in distributed program, including test data, etc.: 2 379 437 Distribution format: tar.gz Programming language: C++ Computer: Pentium 3 PC 2.4 GHz or higher, Borland C++ Builder v. 6. A precompiled Windows version is included in the distribution package Operating system: Windows 32 bit versions RAM: 10 MB Word size: 32 bits Classification: 17.6 Nature of problem: The demand for advanced highly effective experimental data analysis functions is enormous. The library package represents one approach to give the physicists the possibility to use the advanced routines simply by calling them from their own programs. SpecAnalysLib is a collection of functions for analysis of one- and two-parameter γ-ray spectra, but they can be used for other types of data as well. The library consists of sophisticated functions for background elimination, smoothing, peak searching, deconvolution, and peak fitting. Solution method: The algorithms of background estimation are based on Sensitive Non-linear Iterative Peak (SNIP) clipping algorithm. The smoothing algorithms are based on the convolution of the original data with several types of filters and algorithms based on discrete

  1. Inferring gene expression dynamics via functional regression analysis

    Directory of Open Access Journals (Sweden)

    Leng Xiaoyan

    2008-01-01

    Full Text Available Abstract Background Temporal gene expression profiles characterize the time-dynamics of expression of specific genes and are increasingly collected in current gene expression experiments. In the analysis of experiments where gene expression is obtained over the life cycle, it is of interest to relate temporal patterns of gene expression associated with different developmental stages to each other to study patterns of long-term developmental gene regulation. We use tools from functional data analysis to study dynamic changes by relating temporal gene expression profiles of different developmental stages to each other. Results We demonstrate that functional regression methodology can pinpoint relationships that exist between temporary gene expression profiles for different life cycle phases and incorporates dimension reduction as needed for these high-dimensional data. By applying these tools, gene expression profiles for pupa and adult phases are found to be strongly related to the profiles of the same genes obtained during the embryo phase. Moreover, one can distinguish between gene groups that exhibit relationships with positive and others with negative associations between later life and embryonal expression profiles. Specifically, we find a positive relationship in expression for muscle development related genes, and a negative relationship for strictly maternal genes for Drosophila, using temporal gene expression profiles. Conclusion Our findings point to specific reactivation patterns of gene expression during the Drosophila life cycle which differ in characteristic ways between various gene groups. Functional regression emerges as a useful tool for relating gene expression patterns from different developmental stages, and avoids the problems with large numbers of parameters and multiple testing that affect alternative approaches.

  2. IMAGING OF BRAIN FUNCTION BASED ON THE ANALYSIS OF FUNCTIONAL CONNECTIVITY - IMAGING ANALYSIS OF BRAIN FUNCTION BY FMRI AFTER ACUPUNCTURE AT LR3 IN HEALTHY INDIVIDUALS.

    Science.gov (United States)

    Zheng, Yu; Wang, Yuying; Lan, Yujun; Qu, Xiaodong; Lin, Kelin; Zhang, Jiping; Qu, Shanshan; Wang, Yanjie; Tang, Chunzhi; Huang, Yong

    2016-01-01

    This Study observed the relevant brain areas activated by acupuncture at the Taichong acupoint (LR3) and analyzed the functional connectivity among brain areas using resting state functional magnetic resonance imaging (fMRI) to explore the acupoint specificity of the Taichong acupoint. A total of 45 healthy subjects were randomly divided into the Taichong (LR3) group, sham acupuncture group and sham acupoint group. Subjects received resting state fMRI before acupuncture, after true (sham) acupuncture in each group. Analysis of changes in connectivity among the brain areas was performed using the brain functional connectivity method. The right cerebrum temporal lobe was selected as the seed point to analyze the functional connectivity. It had a functional connectivity with right cerebrum superior frontal gyrus, limbic lobe cingulate gyrus and left cerebrum inferior temporal gyrus (BA 37), inferior parietal lobule compared by before vs. after acupuncture at LR3, and right cerebrum sub-lobar insula and left cerebrum middle frontal gyrus, medial frontal gyrus compared by true vs. sham acupuncture at LR3, and right cerebrum occipital lobe cuneus, occipital lobe sub-gyral, parietal lobe precuneus and left cerebellum anterior lobe culmen by acupuncture at LR3 vs. sham acupoint. Acupuncture at LR3 mainly specifically activated the brain functional network that participates in visual function, associative function, and emotion cognition, which are similar to the features on LR3 in tradition Chinese medicine. These brain areas constituted a neural network structure with specific functions that had specific reference values for the interpretation of the acupoint specificity of the Taichong acupoint.

  3. Identification and functional analysis of secreted effectors from phytoparasitic nematodes.

    Science.gov (United States)

    Rehman, Sajid; Gupta, Vijai K; Goyal, Aakash K

    2016-03-21

    Plant parasitic nematodes develop an intimate and long-term feeding relationship with their host plants. They induce a multi-nucleate feeding site close to the vascular bundle in the roots of their host plant and remain sessile for the rest of their life. Nematode secretions, produced in the oesophageal glands and secreted through a hollow stylet into the host plant cytoplasm, are believed to play key role in pathogenesis. To combat these persistent pathogens, the identity and functional analysis of secreted effectors can serve as a key to devise durable control measures. In this review, we will recapitulate the knowledge over the identification and functional characterization of secreted nematode effector repertoire from phytoparasitic nematodes. Despite considerable efforts, the identity of genes encoding nematode secreted proteins has long been severely hampered because of their microscopic size, long generation time and obligate biotrophic nature. The methodologies such as bioinformatics, protein structure modeling, in situ hybridization microscopy, and protein-protein interaction have been used to identify and to attribute functions to the effectors. In addition, RNA interference (RNAi) has been instrumental to decipher the role of the genes encoding secreted effectors necessary for parasitism and genes attributed to normal development. Recent comparative and functional genomic approaches have accelerated the identification of effectors from phytoparasitic nematodes and offers opportunities to control these pathogens. Plant parasitic nematodes pose a serious threat to global food security of various economically important crops. There is a wealth of genomic and transcriptomic information available on plant parasitic nematodes and comparative genomics has identified many effectors. Bioengineering crops with dsRNA of phytonematode genes can disrupt the life cycle of parasitic nematodes and therefore holds great promise to develop resistant crops against plant

  4. The functional neuroanatomy of autobiographical memory: A meta-analysis

    Science.gov (United States)

    Svoboda, Eva; McKinnon, Margaret C.; Levine, Brian

    2007-01-01

    Autobiographical memory (AM) entails a complex set of operations, including episodic memory, self-reflection, emotion, visual imagery, attention, executive functions, and semantic processes. The heterogeneous nature of AM poses significant challenges in capturing its behavioral and neuroanatomical correlates. Investigators have recently turned their attention to the functional neuroanatomy of AM. We used the effect-location method of meta-analysis to analyze data from 24 functional imaging studies of AM. The results indicated a core neural network of left-lateralized regions, including the medial and ventrolateral prefrontal, medial and lateral temporal and retrosplenial/posterior cingulate cortices, the temporoparietal junction and the cerebellum. Secondary and tertiary regions, less frequently reported in imaging studies of AM, are also identified. We examined the neural correlates of putative component processes in AM, including, executive functions, self-reflection, episodic remembering and visuospatial processing. We also separately analyzed the effect of select variables on the AM network across individual studies, including memory age, qualitative factors (personal significance, level of detail and vividness), semantic and emotional content, and the effect of reference conditions. We found that memory age effects on medial temporal lobe structures may be modulated by qualitative aspects of memory. Studies using rest as a control task masked process-specific components of the AM neural network. Our findings support a neural distinction between episodic and semantic memory in AM. Finally, emotional events produced a shift in lateralization of the AM network with activation observed in emotion-centered regions and deactivation (or lack of activation) observed in regions associated with cognitive processes. PMID:16806314

  5. Memory-efficient analysis of dense functional connectomes

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    Kristian Loewe

    2016-11-01

    Full Text Available The functioning of the human brain relies on the interplay and integration of numerous individual units within a complex network. To identify network configurations characteristic of specific cognitive tasks or mental illnesses, functional connectomes can be constructed based on the assessment of synchronous fMRI activity at separate brain sites, and then analyzed using graph-theoretical concepts. In most previous studies, relatively coarse parcellations of the brain were used to define regions as graphical nodes. Such parcellated connectomes are highly dependent on parcellation quality because regional and functional boundaries need to be relatively consistent for the results to be interpretable. In contrast, dense connectomes are not subject to this limitation, since the parcellation inherent to the data is used to define graphical nodes, also allowing for a more detailed spatial mapping of connectivity patterns. However, dense connectomes are associated with considerable computational demands in terms of both time and memory requirements. The memory required to explicitly store dense connectomes in main memory can render their analysis infeasible, especially when considering high-resolution data or analyses across multiple subjects or conditions. Here, we present an object-based matrix representation that achieves a very low memory footprint by computing matrix elements on demand instead of explicitly storing them. In doing so, memory required for a dense connectome is reduced to the amount needed to store the underlying time series data. Based on theoretical considerations and benchmarks, different matrix object implementations and additional programs (based on available Matlab functions and Matlab-based third-party software are compared with regard to their computational efficiency in terms of memory requirements and computation time. The matrix implementation based on on-demand computations has very low memory requirements thus enabling

  6. Memory-Efficient Analysis of Dense Functional Connectomes.

    Science.gov (United States)

    Loewe, Kristian; Donohue, Sarah E; Schoenfeld, Mircea A; Kruse, Rudolf; Borgelt, Christian

    2016-01-01

    The functioning of the human brain relies on the interplay and integration of numerous individual units within a complex network. To identify network configurations characteristic of specific cognitive tasks or mental illnesses, functional connectomes can be constructed based on the assessment of synchronous fMRI activity at separate brain sites, and then analyzed using graph-theoretical concepts. In most previous studies, relatively coarse parcellations of the brain were used to define regions as graphical nodes. Such parcellated connectomes are highly dependent on parcellation quality because regional and functional boundaries need to be relatively consistent for the results to be interpretable. In contrast, dense connectomes are not subject to this limitation, since the parcellation inherent to the data is used to define graphical nodes, also allowing for a more detailed spatial mapping of connectivity patterns. However, dense connectomes are associated with considerable computational demands in terms of both time and memory requirements. The memory required to explicitly store dense connectomes in main memory can render their analysis infeasible, especially when considering high-resolution data or analyses across multiple subjects or conditions. Here, we present an object-based matrix representation that achieves a very low memory footprint by computing matrix elements on demand instead of explicitly storing them. In doing so, memory required for a dense connectome is reduced to the amount needed to store the underlying time series data. Based on theoretical considerations and benchmarks, different matrix object implementations and additional programs (based on available Matlab functions and Matlab-based third-party software) are compared with regard to their computational efficiency. The matrix implementation based on on-demand computations has very low memory requirements, thus enabling analyses that would be otherwise infeasible to conduct due to

  7. Tucker Tensor analysis of Matern functions in spatial statistics

    KAUST Repository

    Litvinenko, Alexander

    2018-03-09

    In this work, we describe advanced numerical tools for working with multivariate functions and for the analysis of large data sets. These tools will drastically reduce the required computing time and the storage cost, and, therefore, will allow us to consider much larger data sets or finer meshes. Covariance matrices are crucial in spatio-temporal statistical tasks, but are often very expensive to compute and store, especially in 3D. Therefore, we approximate covariance functions by cheap surrogates in a low-rank tensor format. We apply the Tucker and canonical tensor decompositions to a family of Matern- and Slater-type functions with varying parameters and demonstrate numerically that their approximations exhibit exponentially fast convergence. We prove the exponential convergence of the Tucker and canonical approximations in tensor rank parameters. Several statistical operations are performed in this low-rank tensor format, including evaluating the conditional covariance matrix, spatially averaged estimation variance, computing a quadratic form, determinant, trace, loglikelihood, inverse, and Cholesky decomposition of a large covariance matrix. Low-rank tensor approximations reduce the computing and storage costs essentially. For example, the storage cost is reduced from an exponential O(n^d) to a linear scaling O(drn), where d is the spatial dimension, n is the number of mesh points in one direction, and r is the tensor rank. Prerequisites for applicability of the proposed techniques are the assumptions that the data, locations, and measurements lie on a tensor (axes-parallel) grid and that the covariance function depends on a distance, ||x-y||.

  8. Discrete-Trial Functional Analysis and Functional Communication Training with Three Individuals with Autism and Severe Problem Behavior

    Science.gov (United States)

    Schmidt, Jonathan D.; Drasgow, Erik; Halle, James W.; Martin, Christian A.; Bliss, Sacha A.

    2014-01-01

    Discrete-trial functional analysis (DTFA) is an experimental method for determining the variables maintaining problem behavior in the context of natural routines. Functional communication training (FCT) is an effective method for replacing problem behavior, once identified, with a functionally equivalent response. We implemented these procedures…

  9. Pair distribution function analysis applied to decahedral gold nanoparticles

    International Nuclear Information System (INIS)

    Nakotte, H; Silkwood, C; Kiefer, B; Karpov, D; Fohtung, E; Page, K; Wang, H-W; Olds, D; Manna, S; Fullerton, E E

    2017-01-01

    The five-fold symmetry of face-centered cubic (fcc) derived nanoparticles is inconsistent with the translational symmetry of a Bravais lattice and generally explained by multiple twinning of a tetrahedral subunit about a (joint) symmetry axis, with or without structural modification to the fcc motif. Unlike in bulk materials, five-fold twinning in cubic nanoparticles is common and strongly affects their structural, chemical, and electronic properties. To test and verify theoretical approaches, it is therefore pertinent that the local structural features of such materials can be fully characterized. The small size of nanoparticles severely limits the application of traditional analysis techniques, such as Bragg diffraction. A complete description of the atomic arrangement in nanoparticles therefore requires a departure from the concept of translational symmetry, and prevents fully evaluating all the structural features experimentally. We describe how recent advances in instrumentation, together with the increasing power of computing, are shaping the development of alternative analysis methods of scattering data for nanostructures. We present the application of Debye scattering and pair distribution function (PDF) analysis towards modeling of the total scattering data for the example of decahedral gold nanoparticles. PDF measurements provide a statistical description of the pair correlations of atoms within a material, allowing one to evaluate the probability of finding two atoms within a given distance. We explored the sensitivity of existing synchrotron x-ray PDF instruments for distinguishing four different simple models for our gold nanoparticles: a multiply twinned fcc decahedron with either a single gap or multiple distributed gaps, a relaxed body-centered orthorhombic (bco) decahedron, and a hybrid decahedron. The data simulations of the models were then compared with experimental data from synchrotron x-ray total scattering. We present our experimentally

  10. Mode Shape Analysis of Multiple Cracked Functionally Graded Timoshenko Beams

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    Tran Van Lien

    Full Text Available Abstract The present paper addresses free vibration of multiple cracked Timoshenko beams made of Functionally Graded Material (FGM. Cracks are modeled by rotational spring of stiffness calculated from the crack depth and material properties vary according to the power law throughout the beam thickness. Governing equations for free vibration of the beam are formulated with taking into account actual position of the neutral plane. The obtained frequency equation and mode shapes are used for analysis of the beam mode shapes in dependence on the material and crack parameters. Numerical results validate usefulness of the proposed herein theory and show that mode shapes are good indication for detecting multiple cracks in Timoshenko FGM beams.

  11. Use of universal functional optimisation for TL glow curve analysis

    International Nuclear Information System (INIS)

    Pernicka, F.; Linh, H.Q.

    1996-01-01

    The effective use of any TL instrument requires an efficient software package to be able to fulfil different tasks required by research and practical applications. One of the standard features of the package used at the NPI Prague is the application of the interactive modular system Universal Functional Optimisation (UFO) for glow curve deconvolution. The whole system has been tested on standard glow curves using different models of the TL process (a single peak described by the Podgorsak approximation, first order kinetics and/or general order kinetics). Calculated values of basic TL parameters (E and s) show a good agreement with the results obtained by other authors. The main advantage of the system is in its modularity that enables flexible changes in the TL model and mathematical procedures of the glow curve analysis. (author)

  12. Plutonium Finishing Plant transition project function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and function hierarchy charts that describe what needs to be performed to deactivate PFP and to continue safe storage, treatment and disposition of Plutonium and High Enriched Uranium

  13. Functional Analysis of HIV/AIDS Stigma: Consensus or Divergence?

    Science.gov (United States)

    Hosseinzadeh, Hassan; Hossain, Syeda Zakia

    2011-01-01

    Functional theory proposes that attitudes may serve a variety of purposes for individuals. This study aimed to determine whether stigmatized attitudes toward HIV/AIDS serve the same function for all (consensus function) or serve different functions for different individuals (divergence function) by assessing various aspects of HIV/AIDS stigma…

  14. Functional analysis of PGRP-LA in Drosophila immunity.

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    Mathilde Gendrin

    Full Text Available PeptidoGlycan Recognition Proteins (PGRPs are key regulators of the insect innate antibacterial response. Even if they have been intensively studied, some of them have yet unknown functions. Here, we present a functional analysis of PGRP-LA, an as yet uncharacterized Drosophila PGRP. The PGRP-LA gene is located in cluster with PGRP-LC and PGRP-LF, which encode a receptor and a negative regulator of the Imd pathway, respectively. Structure predictions indicate that PGRP-LA would not bind to peptidoglycan, pointing to a regulatory role of this PGRP. PGRP-LA expression was enriched in barrier epithelia, but low in the fat body. Use of a newly generated PGRP-LA deficient mutant indicates that PGRP-LA is not required for the production of antimicrobial peptides by the fat body in response to a systemic infection. Focusing on the respiratory tract, where PGRP-LA is strongly expressed, we conducted a genome-wide microarray analysis of the tracheal immune response of wild-type, Relish, and PGRP-LA mutant larvae. Comparing our data to previous microarray studies, we report that a majority of genes regulated in the trachea upon infection differ from those induced in the gut or the fat body. Importantly, antimicrobial peptide gene expression was reduced in the tracheae of larvae and in the adult gut of PGRP-LA-deficient Drosophila upon oral bacterial infection. Together, our results suggest that PGRP-LA positively regulates the Imd pathway in barrier epithelia.

  15. Fast dynamics perturbation analysis for prediction of protein functional sites

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    Cohn Judith D

    2008-01-01

    Full Text Available Abstract Background We present a fast version of the dynamics perturbation analysis (DPA algorithm to predict functional sites in protein structures. The original DPA algorithm finds regions in proteins where interactions cause a large change in the protein conformational distribution, as measured using the relative entropy Dx. Such regions are associated with functional sites. Results The Fast DPA algorithm, which accelerates DPA calculations, is motivated by an empirical observation that Dx in a normal-modes model is highly correlated with an entropic term that only depends on the eigenvalues of the normal modes. The eigenvalues are accurately estimated using first-order perturbation theory, resulting in a N-fold reduction in the overall computational requirements of the algorithm, where N is the number of residues in the protein. The performance of the original and Fast DPA algorithms was compared using protein structures from a standard small-molecule docking test set. For nominal implementations of each algorithm, top-ranked Fast DPA predictions overlapped the true binding site 94% of the time, compared to 87% of the time for original DPA. In addition, per-protein recall statistics (fraction of binding-site residues that are among predicted residues were slightly better for Fast DPA. On the other hand, per-protein precision statistics (fraction of predicted residues that are among binding-site residues were slightly better using original DPA. Overall, the performance of Fast DPA in predicting ligand-binding-site residues was comparable to that of the original DPA algorithm. Conclusion Compared to the original DPA algorithm, the decreased run time with comparable performance makes Fast DPA well-suited for implementation on a web server and for high-throughput analysis.

  16. Novel axolotl cardiac function analysis method using magnetic resonance imaging.

    Directory of Open Access Journals (Sweden)

    Pedro Gomes Sanches

    Full Text Available The salamander axolotl is capable of complete regeneration of amputated heart tissue. However, non-invasive imaging tools for assessing its cardiac function were so far not employed. In this study, cardiac magnetic resonance imaging is introduced as a non-invasive technique to image heart function of axolotls. Three axolotls were imaged with magnetic resonance imaging using a retrospectively gated Fast Low Angle Shot cine sequence. Within one scanning session the axolotl heart was imaged three times in all planes, consecutively. Heart rate, ejection fraction, stroke volume and cardiac output were calculated using three techniques: (1 combined long-axis, (2 short-axis series, and (3 ultrasound (control for heart rate only. All values are presented as mean ± standard deviation. Heart rate (beats per minute among different animals was 32.2±6.0 (long axis, 30.4±5.5 (short axis and 32.7±4.9 (ultrasound and statistically similar regardless of the imaging method (p > 0.05. Ejection fraction (% was 59.6±10.8 (long axis and 48.1±11.3 (short axis and it differed significantly (p = 0.019. Stroke volume (μl/beat was 133.7±33.7 (long axis and 93.2±31.2 (short axis, also differed significantly (p = 0.015. Calculations were consistent among the animals and over three repeated measurements. The heart rate varied depending on depth of anaesthesia. We described a new method for defining and imaging the anatomical planes of the axolotl heart and propose one of our techniques (long axis analysis may prove useful in defining cardiac function in regenerating axolotl hearts.

  17. Functional connectivity analysis of brain hemodynamics during rubber hand illusion.

    Science.gov (United States)

    Arizono, Naoki; Kondo, Toshiyuki

    2015-08-01

    Embodied cognition has been eagerly studied in the recent neuroscience research field. In particular, hand ownership has been investigated through the rubber hand illusion (RHI). Most of the research measured the brain activities during the RHI by using EEG, fMRI, etc., however, near-infrared spectroscopy (NIRS) has not yet been utilized. Here we attempt to measure the brain activities during the RHI task with NIRS, and analyze the functional connectivity so as to understand the relationship between NIRS features and the state of embodied cognition. For the purpose, we developed a visuo-tactile stimulator in the study. As a result, we found that the subjects felt illusory experience showed significant peaks of oxy-Hb in both prefrontal and premotor cortices during RHI. Furthermore, we confirmed a reliable causality connection from right prefrontal to right premotor cortex. This result suggests that the RHI is associated with the neural circuits underlying motor control. Therefore, we considered that the RHI with the functional connectivity analysis will become an appropriate model investigating a biomarker for neurorehabilitation, and the diagnosis of the mental disorders.

  18. Pectin: cell biology and prospects for functional analysis.

    Science.gov (United States)

    Willats, W G; McCartney, L; Mackie, W; Knox, J P

    2001-09-01

    Pectin is a major component of primary cell walls of all land plants and encompasses a range of galacturonic acid-rich polysaccharides. Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan-I and rhamnogalacturonan-II) are thought to occur in all primary cell walls. This review surveys what is known about the structure and function of these pectin domains. The high degree of structural complexity and heterogeneity of the pectic matrix is produced both during biosynthesis in the endomembrane system and as a result of the action of an array of wall-based pectin-modifying enzymes. Recent developments in analytical techniques and in the generation of anti-pectin probes have begun to place the structural complexity of pectin in cell biological and developmental contexts. The in muro de-methyl-esterification of homogalacturonan by pectin methyl esterases is emerging as a key process for the local modulation of matrix properties. Rhamnogalacturonan-I comprises a highly diverse population of spatially and developmentally regulated polymers, whereas rhamnogalacturonan-II appears to be a highly conserved and stable pectic domain. Current knowledge of biosynthetic enzymes, plant and microbial pectinases and the interactions of pectin with other cell wall components and the impact of molecular genetic approaches are reviewed in terms of the functional analysis of pectic polysaccharides in plant growth and development.

  19. Functional analysis of virion host shutoff protein of pseudorabies virus

    International Nuclear Information System (INIS)

    Lin, H.-W.; Chang, Y.-Y.; Wong, M.-L.; Lin, J.-W.; Chang, T.-J.

    2004-01-01

    During lytic infection, the virion host shutoff (vhs) protein of alphaherpesviruses causes the degradation of mRNAs nonspecifically. In this work, we cloned the vhs gene (UL41 open reading frame) of pseudorabies virus (PRV; TNL strain) by PCR, and its nucleotide sequences were determined. The PCR product of vhs gene was subcloned into the prokaryotic pET32b expression vector, and production of the recombinant vhs protein was examined by SDS-PAGE. Result of Western blotting demonstrated that our recombinant vhs protein reacted with antiserum against a synthetic peptide of 17 amino acids of the vhs protein. After purification with nickel-chelate affinity chromatography, the purified recombinant vhs protein exhibited in vitro ribonuclease activity as expected. We further cloned the vhs gene into eukaryotic expression vectors and investigated the intracellular function of vhs protein by DNA transfection. By transient trasfection and CAT assay, we found the CAT activity was reduced in the presence of vhs, indicating that degradation of mRNA of the CAT gene was caused by the vhs. Furthermore, our results showed that the plaque formation of pseudorabies virus was blocked by exogenous vhs. Taken together, we have cloned the vhs gene of pseudorabies virus (TNL strain) and conducted functional analysis of the recombinant vhs protein in vitro as well as in vivo

  20. Correlation between videogame mechanics and executive functions through EEG analysis.

    Science.gov (United States)

    Mondéjar, Tania; Hervás, Ramón; Johnson, Esperanza; Gutierrez, Carlos; Latorre, José Miguel

    2016-10-01

    This paper addresses a different point of view of videogames, specifically serious games for health. This paper contributes to that area with a multidisciplinary perspective focus on neurosciences and computation. The experiment population has been pre-adolescents between the ages of 8 and 12 without any cognitive issues. The experiment consisted in users playing videogames as well as performing traditional psychological assessments; during these tasks the frontal brain activity was evaluated. The main goal was to analyse how the frontal lobe of the brain (executive function) works in terms of prominent cognitive skills during five types of game mechanics widely used in commercial videogames. The analysis was made by collecting brain signals during the two phases of the experiment, where the signals were analysed with an electroencephalogram neuroheadset. The validated hypotheses were whether videogames can develop executive functioning and if it was possible to identify which kind of cognitive skills are developed during each kind of typical videogame mechanic. The results contribute to the design of serious games for health purposes on a conceptual level, particularly in support of the diagnosis and treatment of cognitive-related pathologies. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Structural-functional and parametric analysis of the social function of pharmaceutical industry

    Directory of Open Access Journals (Sweden)

    N. O. Tkachenko

    2016-12-01

    Full Text Available Pharmacy has always had a special (social value and was sensitive to the new social changes in the society and the state. These changes allow better understand the issues associated with increasing the efficiency of pharmaceutical care to the population. The aim of the work: identify, justify and to summarize the main elements of the social function of pharmacy, as a component of health care system, to further evaluate the properties of the pharmaceutical industry as a system. Materials and methods. To achieve this goal the principle of a systematic approach and the complex of research methods such as structural, functional and parametric analysis, logical knowledge and comparison, ad also generalization have been used. As materials of research, we used the results of fundamental and applied research of national and foreign experts on the issue. Results and discussion. The basic principles of the welfare state and pharmacy as socially oriented sectors of the economy have been determined. We have found that the pharmaceutical industry is an agent, which implements a number of elements of the social function, such as pharmaceutical assistance to the population, the production of social goods (drugs, medical products, medical cosmetics, etc., creating and providing of working places, paying taxes (replenishment of the state budget, the formation and development of human capital, research and innovation activities, charity and sponsorship, environmental protection. Ukraine formally acceded to United Nations document, «Agenda for the XXI Century». This agreement commits our government to implement development and implementation of sustainable development strategies. Its main components are the social responsibility, social integration, an efficient worker and effective owner. Social responsibility acts as a reverse reaction on realization of social policy through the main sectors of the economy. Conclusions. We have summarized the information and

  2. Functional Principal Component Analysis and Randomized Sparse Clustering Algorithm for Medical Image Analysis

    Science.gov (United States)

    Lin, Nan; Jiang, Junhai; Guo, Shicheng; Xiong, Momiao

    2015-01-01

    Due to the advancement in sensor technology, the growing large medical image data have the ability to visualize the anatomical changes in biological tissues. As a consequence, the medical images have the potential to enhance the diagnosis of disease, the prediction of clinical outcomes and the characterization of disease progression. But in the meantime, the growing data dimensions pose great methodological and computational challenges for the representation and selection of features in image cluster analysis. To address these challenges, we first extend the functional principal component analysis (FPCA) from one dimension to two dimensions to fully capture the space variation of image the signals. The image signals contain a large number of redundant features which provide no additional information for clustering analysis. The widely used methods for removing the irrelevant features are sparse clustering algorithms using a lasso-type penalty to select the features. However, the accuracy of clustering using a lasso-type penalty depends on the selection of the penalty parameters and the threshold value. In practice, they are difficult to determine. Recently, randomized algorithms have received a great deal of attentions in big data analysis. This paper presents a randomized algorithm for accurate feature selection in image clustering analysis. The proposed method is applied to both the liver and kidney cancer histology image data from the TCGA database. The results demonstrate that the randomized feature selection method coupled with functional principal component analysis substantially outperforms the current sparse clustering algorithms in image cluster analysis. PMID:26196383

  3. Analysis of reproductive function in persons exposed to chronic radiation

    International Nuclear Information System (INIS)

    Kossenko, M.M.; Ostroumova, E.V.; Vyushkova, O.V.

    2000-01-01

    The purpose of the study was to analyze the reproductive function in individuals exposed to radiation in the riverside villages on the Techa in the Southern Urals. The exposure of the population, numbering 28000, occurred in 1950-1956 as a result of discharges into the river of radioactive wastes from the Mayak facility for processing weapon plutonium. The residents were exposed to chronic radiation, both external and internal. The range of exposure doses to gonads was sufficiently wide: 20-1270 mSv. However, the distribution of doses among the exposed individuals was ununiform, and the proportion of people whose dose was below 120 mGy accounted for 74%. The following characteristics of exposed women were analyzed: menstrual function, outcomes of pregnancy, birth rates, health status for newborns. The analysis of the menstrual function in exposed women showed that in persons exposed in childhood, menarche was registered at the age of 14.3 years, on the average (based on literature sources, menarche is attained at the age of 13 for unexposed population). The mean age at menopause was 47.9 years for exposed women (the respective mean value for Russia is 50.8 years). Pregnancy outcomes were analyzed in 9000 exposed women. The rate of medical and criminal abortions was estimated as 79 per 100 labors. The rate of spontaneous abortions for exposed women was slightly higher, 3.11%, than for controls, 2.30%; these difference, however, were statistically insignificant. The total loss of fetus or neonate (unfavorable outcomes of pregnancy: spontaneous abortions, stillbirths, early neonatal death) was estimated to be 4.58% at zero dose. Exposure to gonads at the dose 1 Sv, estimated using the above-indicated method, yielded 3% of additional unfavorable outcomes of pregnancy. It was shown, based on the analysis of birth rates for the Techa Cohort that they had not undergone any essential changes over the first 25 years of exposure compared to the respective coefficients for

  4. Analysis of reproductive function in persons exposed to chronic radiation

    Energy Technology Data Exchange (ETDEWEB)

    Kossenko, M.M.; Ostroumova, E.V.; Vyushkova, O.V. [Urals Research Center for Radiation Medicine, Chelyabinsk (Russian Federation)

    2000-05-01

    The purpose of the study was to analyze the reproductive function in individuals exposed to radiation in the riverside villages on the Techa in the Southern Urals. The exposure of the population, numbering 28000, occurred in 1950-1956 as a result of discharges into the river of radioactive wastes from the Mayak facility for processing weapon plutonium. The residents were exposed to chronic radiation, both external and internal. The range of exposure doses to gonads was sufficiently wide: 20-1270 mSv. However, the distribution of doses among the exposed individuals was ununiform, and the proportion of people whose dose was below 120 mGy accounted for 74%. The following characteristics of exposed women were analyzed: menstrual function, outcomes of pregnancy, birth rates, health status for newborns. The analysis of the menstrual function in exposed women showed that in persons exposed in childhood, menarche was registered at the age of 14.3 years, on the average (based on literature sources, menarche is attained at the age of 13 for unexposed population). The mean age at menopause was 47.9 years for exposed women (the respective mean value for Russia is 50.8 years). Pregnancy outcomes were analyzed in 9000 exposed women. The rate of medical and criminal abortions was estimated as 79 per 100 labors. The rate of spontaneous abortions for exposed women was slightly higher, 3.11%, than for controls, 2.30%; these difference, however, were statistically insignificant. The total loss of fetus or neonate (unfavorable outcomes of pregnancy: spontaneous abortions, stillbirths, early neonatal death) was estimated to be 4.58% at zero dose. Exposure to gonads at the dose 1 Sv, estimated using the above-indicated method, yielded 3% of additional unfavorable outcomes of pregnancy. It was shown, based on the analysis of birth rates for the Techa Cohort that they had not undergone any essential changes over the first 25 years of exposure compared to the respective coefficients for

  5. Automatic quantitative analysis of liver functions by a computer system

    International Nuclear Information System (INIS)

    Shinpo, Takako

    1984-01-01

    In the previous paper, we confirmed the clinical usefulness of hepatic clearance (hepatic blood flow), which is the hepatic uptake and blood disappearance rate coefficients. These were obtained by the initial slope index of each minute during a period of five frames of a hepatogram by injecting sup(99m)Tc-Sn-colloid 37 MBq. To analyze the information simply, rapidly and accurately, we developed a automatic quantitative analysis for liver functions. Information was obtained every quarter minute during a period of 60 frames of the sequential image. The sequential counts were measured for the heart, whole liver, both left lobe and right lobes using a computer connected to a scintillation camera. We measured the effective hepatic blood flow, from the disappearance rate multiplied by the percentage of hepatic uptake as follows, (liver counts)/(tatal counts of the field) Our method of analysis automatically recorded the reappearance graph of the disappearance curve and uptake curve on the basis of the heart and the whole liver, respectively; and computed using BASIC language. This method makes it possible to obtain the image of the initial uptake of sup(99m)Tc-Sn-colloid into the liver by a small dose of it. (author)

  6. Age-Related Differences and Heterogeneity in Executive Functions: Analysis of NAB Executive Functions Module Scores.

    Science.gov (United States)

    Buczylowska, Dorota; Petermann, Franz

    2016-05-01

    Normative data from the German adaptation of the Neuropsychological Assessment Battery were used to examine age-related differences in 6 executive function tasks. A multivariate analysis of variance was employed to investigate the differences in performance in 484 participants aged 18-99 years. The coefficient of variation was calculated to compare the heterogeneity of scores between 10 age groups. Analyses showed an increase in the dispersion of scores with age, varying from 7% to 289%, in all subtests. Furthermore, age-dependent heterogeneity appeared to be associated with age-dependent decline because the subtests with the greatest increase in dispersion (i.e., Mazes, Planning, and Categories) also exhibited the greatest decrease in mean scores. In contrast, scores for the subtests Letter Fluency, Word Generation, and Judgment had the lowest increase in dispersion with the lowest decrease in mean scores. Consequently, the results presented here show a pattern of age-related differences in executive functioning that is consistent with the concept of crystallized and fluid intelligence. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  7. Analysis of functionality free CASE-tools databases design

    Directory of Open Access Journals (Sweden)

    A. V. Gavrilov

    2016-01-01

    Full Text Available The introduction in the educational process of database design CASEtechnologies requires the institution of significant costs for the purchase of software. A possible solution could be the use of free software peers. At the same time this kind of substitution should be based on even-com representation of the functional characteristics and features of operation of these programs. The purpose of the article – a review of the free and non-profi t CASE-tools database design, as well as their classifi cation on the basis of the analysis functionality. When writing this article were used materials from the offi cial websites of the tool developers. Evaluation of the functional characteristics of CASEtools for database design made exclusively empirically with the direct work with software products. Analysis functionality of tools allow you to distinguish the two categories CASE-tools database design. The first category includes systems with a basic set of features and tools. The most important basic functions of these systems are: management connections to database servers, visual tools to create and modify database objects (tables, views, triggers, procedures, the ability to enter and edit data in table mode, user and privilege management tools, editor SQL-code, means export/import data. CASE-system related to the first category can be used to design and develop simple databases, data management, as well as a means of administration server database. A distinctive feature of the second category of CASE-tools for database design (full-featured systems is the presence of visual designer, allowing to carry out the construction of the database model and automatic creation of the database on the server based on this model. CASE-system related to this categories can be used for the design and development of databases of any structural complexity, as well as a database server administration tool. The article concluded that the

  8. Analysis of error functions in speckle shearing interferometry

    International Nuclear Information System (INIS)

    Wan Saffiey Wan Abdullah

    2001-01-01

    Electronic Speckle Pattern Shearing Interferometry (ESPSI) or shearography has successfully been used in NDT for slope (∂w/ (∂x and / or (∂w/ (∂y) measurement while strain measurement (∂u/ ∂x, ∂v/ ∂y, ∂u/ ∂y and (∂v/ (∂x) is still under investigation. This method is well accepted in industrial applications especially in the aerospace industry. Demand of this method is increasing due to complexity of the test materials and objects. ESPSI has successfully performed in NDT only for qualitative measurement whilst quantitative measurement is the current aim of many manufacturers. Industrial use of such equipment is being completed without considering the errors arising from numerous sources, including wavefront divergence. The majority of commercial systems are operated with diverging object illumination wave fronts without considering the curvature of the object illumination wavefront or the object geometry, when calculating the interferometer fringe function and quantifying data. This thesis reports the novel approach in quantified maximum phase change difference analysis for derivative out-of-plane (OOP) and in-plane (IP) cases that propagate from the divergent illumination wavefront compared to collimated illumination. The theoretical of maximum phase difference is formulated by means of three dependent variables, these being the object distance, illuminated diameter, center of illuminated area and camera distance and illumination angle. The relative maximum phase change difference that may contributed to the error in the measurement analysis in this scope of research is defined by the difference of maximum phase difference value measured by divergent illumination wavefront relative to the maximum phase difference value of collimated illumination wavefront, taken at the edge of illuminated area. Experimental validation using test objects for derivative out-of-plane and derivative in-plane deformation, using a single illumination wavefront

  9. Functional neuroanatomy of meditation: A review and meta-analysis of 78 functional neuroimaging investigations.

    Science.gov (United States)

    Fox, Kieran C R; Dixon, Matthew L; Nijeboer, Savannah; Girn, Manesh; Floman, James L; Lifshitz, Michael; Ellamil, Melissa; Sedlmeier, Peter; Christoff, Kalina

    2016-06-01

    Meditation is a family of mental practices that encompasses a wide array of techniques employing distinctive mental strategies. We systematically reviewed 78 functional neuroimaging (fMRI and PET) studies of meditation, and used activation likelihood estimation to meta-analyze 257 peak foci from 31 experiments involving 527 participants. We found reliably dissociable patterns of brain activation and deactivation for four common styles of meditation (focused attention, mantra recitation, open monitoring, and compassion/loving-kindness), and suggestive differences for three others (visualization, sense-withdrawal, and non-dual awareness practices). Overall, dissociable activation patterns are congruent with the psychological and behavioral aims of each practice. Some brain areas are recruited consistently across multiple techniques-including insula, pre/supplementary motor cortices, dorsal anterior cingulate cortex, and frontopolar cortex-but convergence is the exception rather than the rule. A preliminary effect-size meta-analysis found medium effects for both activations (d=0.59) and deactivations (d=-0.74), suggesting potential practical significance. Our meta-analysis supports the neurophysiological dissociability of meditation practices, but also raises many methodological concerns and suggests avenues for future research. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Functional Group Analysis of Biomass Burning Particles Using Infrared Spectroscopy

    Science.gov (United States)

    Horrell, K.; Lau, A.; Bond, T.; Iraci, L. T.

    2008-12-01

    Biomass burning is a significant source of particulate organic carbon in the atmosphere. These particles affect the energy balance of the atmosphere directly by absorbing and scattering solar radiation, and indirectly through their ability to act as cloud condensation nuclei (CCN). The chemical composition of biomass burning particles influences their ability to act as CCN, thus understanding the chemistry of these particles is required for understanding their effects on climate and air quality. As climate change influences the frequency and severity of boreal forest fires, the influence of biomass burning aerosols on the atmosphere may become significantly greater. Only a small portion of the organic carbon (OC) fraction of these particles has been identified at the molecular level, although several studies have explored the general chemical classes found in biomass burning smoke. To complement those studies and provide additional information about the reactive functional groups present, we are developing a method for polarity-based separation of compound classes found in the OC fraction, followed by infrared (IR) spectroscopic analysis of each polarity fraction. It is our goal to find a simple, relatively low-tech method which will provide a moderate chemical understanding of the entire suite of compounds present in the OC fraction of biomass burning particles. Here we present preliminary results from pine and oak samples representative of Midwestern United States forests burned at several different temperatures. Wood type and combustion temperature are both seen to affect the composition of the particles. The latter seems to affect relative contributions of certain functional groups, while oak demonstrates at least one additional chemical class of compounds, particularly at lower burning temperatures, where gradual solid-gas phase reactions can produce relatively large amounts of incompletely oxidized products.

  11. Functional Analysis of Shewanella, a cross genome comparison.

    Energy Technology Data Exchange (ETDEWEB)

    Serres, Margrethe H.

    2009-05-15

    The bacterial genus Shewanella includes a group of highly versatile organisms that have successfully adapted to life in many environments ranging from aquatic (fresh and marine) to sedimentary (lake and marine sediments, subsurface sediments, sea vent). A unique respiratory capability of the Shewanellas, initially observed for Shewanella oneidensis MR-1, is the ability to use metals and metalloids, including radioactive compounds, as electron acceptors. Members of the Shewanella genus have also been shown to degrade environmental pollutants i.e. halogenated compounds, making this group highly applicable for the DOE mission. S. oneidensis MR-1 has in addition been found to utilize a diverse set of nutrients and to have a large set of genes dedicated to regulation and to sensing of the environment. The sequencing of the S. oneidensis MR-1 genome facilitated experimental and bioinformatics analyses by a group of collaborating researchers, the Shewanella Federation. Through the joint effort and with support from Department of Energy S. oneidensis MR-1 has become a model organism of study. Our work has been a functional analysis of S. oneidensis MR-1, both by itself and as part of a comparative study. We have improved the annotation of gene products, assigned metabolic functions, and analyzed protein families present in S. oneidensis MR-1. The data has been applied to analysis of experimental data (i.e. gene expression, proteome) generated for S. oneidensis MR-1. Further, this work has formed the basis for a comparative study of over 20 members of the Shewanella genus. The species and strains selected for genome sequencing represented an evolutionary gradient of DNA relatedness, ranging from close to intermediate, and to distant. The organisms selected have also adapted to a variety of ecological niches. Through our work we have been able to detect and interpret genome similarities and differences between members of the genus. We have in this way contributed to the

  12. Fourier analysis of heart SPECT slices: from remodelation to function?

    International Nuclear Information System (INIS)

    Zigman, M.; Prpic, H.; Lokner, V.

    1994-01-01

    The aim of this study was to determine character of the spatial distribution of marked erythrocytes in heart chambers, lungs and great blood vessels in relation to function of the left and right heart. Investigation included total of 142 subjects, 28 of which were without subjective and clinical signs of heart disease as well as 56 after myocardial infarction (30 of anterior localization, 26 of inferior infarction), 35 with predominant left heart disease (aortic valve disease, dilatative myocardiopathy, etc.) and 23 with predominant right heart disease (atrial septal defect, mitral valve disease). Radionuclide ventriculography (RNV) at rest, and thorax SPECT were performed in all subjects with 740 MBq Tc-99m after in vivo erythrocyte labelling with pyrophosphate. Ultrasound investigation was performed on all the subjects with heart disease and 87 of them underwent invasive cardiac investigation. RNV analysis revealed scintigraphic data on left and right ventricle: global ejection fraction (GEF), end-systolic volume (ESV), end-diastolic volume (EDV), fast tilling rate (FFR), fast emptying rate (FER) as well as regional wall motion shortening. Reconstruction of 64x64x8 SPECT images resulted in 3x64 slices (transversal, coronal and sagittal slices). Fourier analysis of 20-32 reconstructed slices in all three dimensions gave amplitude image of the intensity distribution of marked erythrocytes in heart chambers lungs and great blood vessels as well as phase display of spatial localization of regional amplitude values. Results of joint ROC curves constructed for detection, localization and character of heart disease in all subjects revealed significant clinical information content of SPECT data. Evaluation of RI retention using amplitude images in 3D provides insight in regional changes of volume, particular for atrial and lung involvement. (author)

  13. Functional Module Analysis for Gene Coexpression Networks with Network Integration.

    Science.gov (United States)

    Zhang, Shuqin; Zhao, Hongyu; Ng, Michael K

    2015-01-01

    Network has been a general tool for studying the complex interactions between different genes, proteins, and other small molecules. Module as a fundamental property of many biological networks has been widely studied and many computational methods have been proposed to identify the modules in an individual network. However, in many cases, a single network is insufficient for module analysis due to the noise in the data or the tuning of parameters when building the biological network. The availability of a large amount of biological networks makes network integration study possible. By integrating such networks, more informative modules for some specific disease can be derived from the networks constructed from different tissues, and consistent factors for different diseases can be inferred. In this paper, we have developed an effective method for module identification from multiple networks under different conditions. The problem is formulated as an optimization model, which combines the module identification in each individual network and alignment of the modules from different networks together. An approximation algorithm based on eigenvector computation is proposed. Our method outperforms the existing methods, especially when the underlying modules in multiple networks are different in simulation studies. We also applied our method to two groups of gene coexpression networks for humans, which include one for three different cancers, and one for three tissues from the morbidly obese patients. We identified 13 modules with three complete subgraphs, and 11 modules with two complete subgraphs, respectively. The modules were validated through Gene Ontology enrichment and KEGG pathway enrichment analysis. We also showed that the main functions of most modules for the corresponding disease have been addressed by other researchers, which may provide the theoretical basis for further studying the modules experimentally.

  14. FUNCTIONAL ANALYSIS OF THE HEALTH SECTOR IN ROMANIA

    Directory of Open Access Journals (Sweden)

    Bogdan Tatiana

    2015-07-01

    Full Text Available This paper comprises an assessment of the Romanian health financing policy and a detailed analysis of income and expenditure trends over the past seven years. The current situation of the health system is evaluated by reviewing the existing health legislation and documents on public health policies from Romania and from abroad, by analyzing the official statistics (the Romanian Yearbook of Health Statistics, Who database and by performing a healthcare system financial analysis. Although the financial efforts of the Romanian state to support the health system have increased, almost all the incomes and expenditures of the health care system having recorded significant increases, the population perception on health services worsened. Financing the health system continues to be inadequate and used in an ineffective way. Health is an essential component of well-being with major socio-economic implications. The organization and functioning of the health system depends on ensuring adequate funding. Romania must develop its health strategy in the context of European Union policies. These policies are based on values and principles such as promoting universal protection against financial risk, promoting a more equitable distribution of the financing burden, promoting equitable provision and use of services relative to need, improving the transparency and accountability of the system to the public, promoting quality and efficiency in service delivery, improving administrative efficiency, while ensuring the financial sustainability of the health system. In this context, in order to support a financially sustainable and high performing health system, the paper includes recommendations for increasing the public incomes in the health insurance system and options to streamline the healthcare services and expenses in the future.

  15. Renal function measured by X-ray fluorescence analysis

    International Nuclear Information System (INIS)

    Boijsen, M.; Jacobsson, L.; Tylen, U.; Sahlgrenska Sjukhuset, Goeteborg

    1987-01-01

    In twenty-six patients injected with metrizoate during urography, plasma was analyzed for iodine concentration using X-ray fluorescence analysis, and total plasma clearance of contrast medium was calculated. Total plasma clearance of 51 Cr-EDTA was also determined, but not simultaneously, in order to find out if the urographic procedure would influence the kidneys to such an extent that the contrast medium clearance value would differ much from the 51 Cr-EDTA clearance value. The errors in the method were assessed and the total error of the contrast medium clearance determination was calculated. When comparing 51 Cr-EDTA and metrizoate clearance a correlation of 0.94 and a mean ratio of 1.046 (SD 0.138) was found. The assessable errors cannot fully explain the standard deviation, which might indicate a transient change in kidney function related to elements of the urographic procedure such as laxation with possible dehydration and/or the contrast medium dose. (orig.)

  16. Functional analysis in the study of differential and integral equations

    International Nuclear Information System (INIS)

    Sell, G.R.

    1976-01-01

    This paper illustrates the use of functional analysis in the study of differential equations. Our particular starting point, the theory of flows or dynamical systems, originated with the work of H. Poincare, who is the founder of the qualitative theory of ordinary differential equations. In the qualitative theory one tries to describe the behaviour of a solution, or a collection of solutions, without ''solving'' the differential equation. As a starting point one assumes the existence, and sometimes the uniqueness, of solutions and then one tries to describe the asymptotic behaviour, as time t→+infinity, of these solutions. We compare the notion of a flow with that of a C 0 -group of bounded linear operators on a Banach space. We shall show how the concept C 0 -group, or more generally a C 0 -semigroup, can be used to study the behaviour of solutions of certain differential and integral equations. Our main objective is to show how the concept of a C 0 -group and especially the notion of weak-compactness can be used to prove the existence of an invariant measure for a flow on a compact Hausdorff space. Applications to the theory of ordinary differential equations are included. (author)

  17. Artificial intelligence applications to design validation and sneak function analysis

    International Nuclear Information System (INIS)

    Stratton, R.C.

    1985-01-01

    An objective of the US space reactor program is to design systems with high reliability and safety of control over long operating lifetimes. Argonne National Laboratory (ANL) is a participant in the National Man-Machine Integration (MMI) program for Liquid Metal Fast Breeder Reactors (LMFBR). A purpose of this program is to promote the development of concepts and technologies that enhance the operational safety and reliability of fast-breeder reactors. Much of the work is directly applicable to the space reactor program. This paper reports on one of the MMI projects being developed by ANL. The project reported pertains to an automated system that demonstrates the use of artificial intelligence (AI) for design validation (DA) and sneak function analysis (SFA). The AI system models the design specification and the physical design of the cooling process assigned to the Argon Cooling System (ACS) at Experimental Breeder Reactor II (EBR-II). The models are developed using heuristic knowledge and natural laws. 13 refs

  18. Mechanical and Thermal Analysis of Classical Functionally Graded Coated Beam

    Directory of Open Access Journals (Sweden)

    Toudehdehghan Abdolreza

    2018-01-01

    Full Text Available The governing equation of a classical rectangular coated beam made of two layers subjected to thermal and uniformly distributed mechanical loads are derived by using the principle of virtual displacements and based on Euler-Bernoulli deformation beam theory (EBT. The aim of this paper was to analyze the static behavior of clamped-clamped thin coated beam under thermo-mechanical load using MATLAB. Two models were considered for composite coated. The first model was consisting of ceramic layer as a coated and substrate which was metal (HC model. The second model was consisting of Functionally Graded Material (FGM as a coated layer and metal substrate (FGC model. From the result it was apparent that the superiority of the FGC composite against conventional coated composite has been demonstrated. From the analysis, the stress level throughout the thickness at the interface of the coated beam for the FGC was reduced. Yet, the deflection in return was observed to increase. Therefore, this could cater to various new engineering applications where warrant the utilization of material that has properties that are well-beyond the capabilities of the conventional or yesteryears materials.

  19. Functional Analysis of the FZF1 Genes of Saccharomyces uvarum

    Directory of Open Access Journals (Sweden)

    Xiaozhen Liu

    2018-02-01

    Full Text Available Being a sister species of Saccharomyces cerevisiae, Saccharomyces uvarum shows great potential regarding the future of the wine industry. The sulfite tolerance of most S. uvarum strains is poor, however. This is a major flaw that limits its utility in the wine industry. In S. cerevisiae, FZF1 plays a positive role in the transcription of SSU1, which encodes a sulfite efflux transport protein that is critical for sulfite tolerance. Although FZF1 has previously been shown to play a role in sulfite tolerance in S. uvarum, there is little information about its action mechanism. To assess the function of FZF1, two over-expression vectors that contained different FZF1 genes, and one FZF1 silencing vector, were constructed and introduced into a sulfite-tolerant S. uvarum strain using electroporation. In addition, an FZF1-deletion strain was constructed. Both of the FZF1-over-expressing strains showed an elevated tolerance to sulfite, and the FZF1-deletion strain showed the opposite effect. Repression of FZF1 transcription failed, however, presumably due to the lack of alleles of DCR1 and AGO. The qRT-PCR analysis was used to examine changes in transcription in the strains. Surprisingly, neither over-expressing strain promoted SSU1 transcription, although MET4 and HAL4 transcripts significantly increased in both sulfite-tolerance increased strains. We conclude that FZF1 plays a different role in the sulfite tolerance of S. uvarum compared to its role in S. cerevisiae.

  20. Exploring functional data analysis and wavelet principal component analysis on ecstasy (MDMA wastewater data

    Directory of Open Access Journals (Sweden)

    Stefania Salvatore

    2016-07-01

    Full Text Available Abstract Background Wastewater-based epidemiology (WBE is a novel approach in drug use epidemiology which aims to monitor the extent of use of various drugs in a community. In this study, we investigate functional principal component analysis (FPCA as a tool for analysing WBE data and compare it to traditional principal component analysis (PCA and to wavelet principal component analysis (WPCA which is more flexible temporally. Methods We analysed temporal wastewater data from 42 European cities collected daily over one week in March 2013. The main temporal features of ecstasy (MDMA were extracted using FPCA using both Fourier and B-spline basis functions with three different smoothing parameters, along with PCA and WPCA with different mother wavelets and shrinkage rules. The stability of FPCA was explored through bootstrapping and analysis of sensitivity to missing data. Results The first three principal components (PCs, functional principal components (FPCs and wavelet principal components (WPCs explained 87.5-99.6 % of the temporal variation between cities, depending on the choice of basis and smoothing. The extracted temporal features from PCA, FPCA and WPCA were consistent. FPCA using Fourier basis and common-optimal smoothing was the most stable and least sensitive to missing data. Conclusion FPCA is a flexible and analytically tractable method for analysing temporal changes in wastewater data, and is robust to missing data. WPCA did not reveal any rapid temporal changes in the data not captured by FPCA. Overall the results suggest FPCA with Fourier basis functions and common-optimal smoothing parameter as the most accurate approach when analysing WBE data.

  1. Speckle tracking analysis: a new tool for left atrial function analysis in systemic hypertension: an overview.

    Science.gov (United States)

    Cameli, Matteo; Ciccone, Marco M; Maiello, Maria; Modesti, Pietro A; Muiesan, Maria L; Scicchitano, Pietro; Novo, Salvatore; Palmiero, Pasquale; Saba, Pier S; Pedrinelli, Roberto

    2016-05-01

    Speckle tracking echocardiography (STE) is an imaging technique applied to the analysis of left atrial function. STE provides a non-Doppler, angle-independent and objective quantification of left atrial myocardial deformation. Data regarding feasibility, accuracy and clinical applications of left atrial strain are rapidly gathering. This review describes the fundamental concepts of left atrial STE, illustrates its pathophysiological background and discusses its emerging role in systemic arterial hypertension.

  2. Functional diversity in plant communities: Theory and analysis ...

    African Journals Online (AJOL)

    Plant functional diversity in community has become a key point in ecology studies recently. The development of species functional diversity was reviewed in the present work. Based on the former original research papers and reviews, we discussed the concept and connotation and put forward a new definition of functional ...

  3. Surface plasmon polariton Wannier-Stark ladder

    Czech Academy of Sciences Publication Activity Database

    Kuzmiak, Vladimír; Maradudin, A. A.; Méndez, E.R.

    2014-01-01

    Roč. 39, č. 6 (2014), s. 1613-1616 ISSN 0146-9592 R&D Projects: GA MŠk LH12009 Institutional support: RVO:67985882 Keywords : Finite difference time domain method * Electromagnetic wave polarization * Plasmons Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 3.292, year: 2014

  4. A Meta-Analysis Detailing Overall Sexual Function and Orgasmic Function in Women Undergoing Midurethral Sling Surgery for Stress Incontinence

    Directory of Open Access Journals (Sweden)

    Nicole Szell, DO

    2017-06-01

    Szell N, Komisaruk B, Goldstein SW, et al. A Meta-Analysis Detailing Overall Sexual Function and Orgasmic Function in Women Undergoing Midurethral Sling Surgery for Stress Incontinence. Sex Med 2017;5:e84–e93.

  5. Functional Analysis of Polyphenol Oxidases by Antisense/Sense Technology

    Directory of Open Access Journals (Sweden)

    Jutharat Attajarusit

    2007-07-01

    overexpressing PPO, suggesting that PPO may have a role in the development of plant water stress and potential for photoinhibition and photooxidative damage that may be unrelated to any effects on the Mehler reaction. These results substantiate the defensive role of PPO and suggest that manipulation of PPO activity in specific tissues has the potential to provide broad-spectrum resistance simultaneously to both disease and insect pests, however, effects of PPO on postharvest quality as well as water stress physiology should also be considered. In addition to the functional analysis of tomato PPO, the application of antisense/sense technology to decipher the functions of PPO in other plant species as well as for commercial uses are discussed.

  6. Real analysis for the undergraduate with an invitation to functional analysis

    CERN Document Server

    Pons, Matthew A

    2014-01-01

    This undergraduate textbook introduces students to the basics of real analysis, provides an introduction to more advanced topics including measure theory and Lebesgue integration, and offers an invitation to functional analysis. While these advanced topics are not typically encountered until graduate study, the text is designed for the beginner. The author’s engaging style makes advanced topics approachable without sacrificing rigor. The text also consistently encourages the reader to pick up a pencil and take an active part in the learning process. Key features include: - examples to reinforce theory; - thorough explanations preceding definitions, theorems and formal proofs; - illustrations to support intuition; - over 450 exercises designed to develop connections between the concrete and abstract. This text takes students on a journey through the basics of real analysis and provides those who wish to delve deeper the opportunity to experience mathematical ideas that are beyond the standard undergraduate c...

  7. Functional proteomic analysis of Ankaferd® Blood Stopper

    Directory of Open Access Journals (Sweden)

    Duygu Özel Demiralp

    2010-06-01

    Full Text Available Objective: Ankaferd® Blood Stopper (ABS comprises a standardized mixture of the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica. The basic mechanism of action for ABS is the formation of an encapsulated protein network that provides focal points for vital erythrocyte aggregation. ABS–induced protein network formation with blood cells, particularly erythrocytes, covers the primary and secondary hemostatic system without disturbing individual coagulation factors. Materials and Methods: To understand the effect mechanisms of ABS on hemostasis, a proteomic analysis using 2D gel electrophoresis and mass spectrometer was performed. Results: Proteins of plant origin in Ankaferd® were NADP-dependent-malic enzyme, ribulose bisphosphate-carboxylase-large chain, maturase K, ATP synthase subunit-beta, ATP synthase subunit-alpha, chalcone-flavanone isomerase-1, chalcone-flavanone isomerase-2, and actin-depolymerizing factor. Furthermore, functional proteomic studies revealed that proteins resembling human peptides have been detected within Ankaferd®, including ATP synthase, mucin-16 (CD164 sialomucin-like 2 protein, coiled-coil domain containing 141 hypothetical protein LOC283638 isoform 1, hypothetical protein LOC283638 isoform 2, dynactin 5, complex I intermediate-associated protein 30, mitochondrial, NADH dehydrogenase (ubiquinone 1 alpha subcomplex, TP synthase, H+ transporting, mitochondrial actin binding 1 isoform, LIM domain and actin binding 1 isoform a, LIM domain and actin binding 1 isoform b, spectrin alpha non erythrocytic 1, prolactin releasing hormone receptor, utrophin, tet oncogene family member 2 isoform b, protein phosphatase 1 regulatory subunit 12A, NIMA (never in mitosis gene a-related kinase, ATP-binding cassette protein C12, Homo sapiens malic enzyme 1, mitochondrial NADP(+-dependent malic enzyme 3, ME2 protein, nuclear factor 1 B-type, abhydrolase domain-containing protein 12B, E

  8. Production Functions for Water Delivery Systems: Analysis and Estimation Using Dual Cost Function and Implicit Price Specifications

    Science.gov (United States)

    Teeples, Ronald; Glyer, David

    1987-05-01

    Both policy and technical analysis of water delivery systems have been based on cost functions that are inconsistent with or are incomplete representations of the neoclassical production functions of economics. We present a full-featured production function model of water delivery which can be estimated from a multiproduct, dual cost function. The model features implicit prices for own-water inputs and is implemented as a jointly estimated system of input share equations and a translog cost function. Likelihood ratio tests are performed showing that a minimally constrained, full-featured production function is a necessary specification of the water delivery operations in our sample. This, plus the model's highly efficient and economically correct parameter estimates, confirms the usefulness of a production function approach to modeling the economic activities of water delivery systems.

  9. An electrophysiological analysis of altered cognitive functions in Huntington disease.

    Science.gov (United States)

    Münte, T F; Ridao-Alonso, M E; Preinfalk, J; Jung, A; Wieringa, B M; Matzke, M; Dengler, R; Johannes, S

    1997-09-01

    Neuropsychological deficits are a main feature of Huntington disease (HD) with previous data suggesting involvement of memory functions and visual processing. To increase the knowledge about cognitive malfunction in HD in the domains of visual processing and memory by the use of modern electrophysiological techniques (event-related potentials [ERPs]). A case-control design was used. Three ERP paradigms were used; a parallel visual search paradigm allowed for the simultaneous processing of a multi-element visual array in search of a target stimulus, while a serial search paradigm with varied numbers of distractor items necessitated a serial one by one scanning of the arrays. The third experiment was a word-recognition memory task. The measurements were obtained in a neurophysiological laboratory of a university hospital. Nine patients with HD and 9 control subjects matched for age, sex, and education were studied. Components of averaged ERPs were quantified by latency and amplitude measures and subjected to statistical analysis. Behavioral measures (search time, hit rate, and recognition accuracy) were assessed as well. The early visual components showed a significant latency shift (delay of about 50 milliseconds) in HD. In the search paradigms the P3 components differentiating target and standard stimuli were virtually absent in HD as was the ERP effect indexing word recognition. This was accompanied by a marked delay in search times and lower hit rates in the search tasks and a grossly reduced recognition accuracy in the memory task. The results suggest marked impairments of patients with HD in early visual sensory processing (early components). Deficits in visual search might be attributed to an impairment to deploy attentional resources across the visual field and/or an inability to control eye movements. The ERPs in the memory task differed grossly from similar data obtained by others in patients with Alzheimer disease, suggesting a different neural basis for

  10. Calculation of the Doppler broadening function using Fourier analysis

    International Nuclear Information System (INIS)

    Goncalves, Alessandro da Cruz

    2010-01-01

    An efficient and precise method for calculation of Doppler broadening function is very important to obtain average group microscopic cross sections, self shielding factors, resonance integrals and others reactor physics parameter. In this thesis two different methods for calculation of Doppler broadening function and interference term will be presented. The main method is based on a new integral form for Doppler broadening function ψ(x,ζ) which gives a mathematical interpretation of the approximation proposed by Bethe and Placzek, as the convolution of the Lorentzian function with a Gaussian function. This interpretation besides leading to a new integral form for ψ(x,ζ), enables to obtain a simple analytic solution for the Doppler broadening function. (author)

  11. Prospect theory: A parametric analysis of functional forms in Brazil

    Directory of Open Access Journals (Sweden)

    Robert Eugene Lobel

    2017-10-01

    Full Text Available This study aims to analyze risk preferences in Brazil based on prospect theory by estimating the risk aversion parameter of the expected utility theory (EUT for a select sample, in addition to the value and probability function parameter, assuming various functional forms, and a newly proposed value function, the modified log. This is the first such study in Brazil, and the parameter results are slightly different from studies in other countries, indicating that subjects are more risk averse and exhibit a smaller loss aversion. Probability distortion is the only common factor. As expected, the study finds that behavioral models are superior to EUT, and models based on prospect theory, the TK and Prelec weighting function, and the value power function show superior performance to others. Finally, the modified log function proposed in the study fits the data well, and can thus be used for future studies in Brazil.

  12. The effect of loss functions on empirical Bayes reliability analysis

    Directory of Open Access Journals (Sweden)

    Camara Vincent A. R.

    1998-01-01

    Full Text Available The aim of the present study is to investigate the sensitivity of empirical Bayes estimates of the reliability function with respect to changing of the loss function. In addition to applying some of the basic analytical results on empirical Bayes reliability obtained with the use of the “popular” squared error loss function, we shall derive some expressions corresponding to empirical Bayes reliability estimates obtained with the Higgins–Tsokos, the Harris and our proposed logarithmic loss functions. The concept of efficiency, along with the notion of integrated mean square error, will be used as a criterion to numerically compare our results. It is shown that empirical Bayes reliability functions are in general sensitive to the choice of the loss function, and that the squared error loss does not always yield the best empirical Bayes reliability estimate.

  13. Control-flow analysis of function calls and returns by abstract interpretation

    DEFF Research Database (Denmark)

    Midtgaard, Jan; Jensen, Thomas P.

    2012-01-01

    Abstract interpretation techniques are used to derive a control-flow analysis for a simple higher-order functional language. The analysis approximates the interprocedural control-flow of both function calls and returns in the presence of first-class functions and tail-call optimization. In additi...... a rational reconstruction of a constraint-based CFA from abstract interpretation principles....

  14. A Systematic Review of Brief Functional Analysis Methodology with Typically Developing Children

    Science.gov (United States)

    Gardner, Andrew W.; Spencer, Trina D.; Boelter, Eric W.; DuBard, Melanie; Jennett, Heather K.

    2012-01-01

    Brief functional analysis (BFA) is an abbreviated assessment methodology derived from traditional extended functional analysis methods. BFAs are often conducted when time constraints in clinics, schools or homes are of concern. While BFAs have been used extensively to identify the function of problem behavior for children with disabilities, their…

  15. Linking Brief Functional Analysis to Intervention Design in General Education Settings

    Science.gov (United States)

    Ishuin, Tifanie

    2009-01-01

    This study focused on the utility and applicability of brief functional analysis in general education settings. The purpose of the study was to first identify the environmental variables maintaining noncompliance through a brief functional analysis, and then to design and implement a functionally equivalent intervention. The participant exhibited…

  16. Assessing the Social Acceptability of the Functional Analysis of Problem Behavior

    Science.gov (United States)

    Langthorne, Paul; McGill, Peter

    2011-01-01

    Although the clinical utility of the functional analysis is well established, its social acceptability has received minimal attention. The current study assessed the social acceptability of functional analysis procedures among 10 parents and 3 teachers of children who had recently received functional analyses. Participants completed a 9-item…

  17. A Quantitative Review of Functional Analysis Procedures in Public School Settings

    Science.gov (United States)

    Solnick, Mark D.; Ardoin, Scott P.

    2010-01-01

    Functional behavioral assessments can consist of indirect, descriptive and experimental procedures, such as a functional analysis. Although the research contains numerous examples demonstrating the effectiveness of functional analysis procedures, experimental conditions are often difficult to implement in classroom settings and analog conditions…

  18. Second-order QCD analysis of the photon structure function

    International Nuclear Information System (INIS)

    Antoniadis, I.; Grunberg, G.

    1983-01-01

    The QCD predictions for the photon structure function are reexamined with particular emphasis on the small-x behavior. A simple parametrization of the real photon structure function, free of 1/x singularity, is derived. The structure function is found to be sensitive at small x to the non-perturbatively calculable constant term in the n=2 moment, and we show that the problem of a negative structure function can be solved on the basis of the knowledge of this single non-perturbative parameter. (orig.)

  19. The effect of loss functions on empirical Bayes reliability analysis

    Directory of Open Access Journals (Sweden)

    Vincent A. R. Camara

    1999-01-01

    Full Text Available The aim of the present study is to investigate the sensitivity of empirical Bayes estimates of the reliability function with respect to changing of the loss function. In addition to applying some of the basic analytical results on empirical Bayes reliability obtained with the use of the “popular” squared error loss function, we shall derive some expressions corresponding to empirical Bayes reliability estimates obtained with the Higgins–Tsokos, the Harris and our proposed logarithmic loss functions. The concept of efficiency, along with the notion of integrated mean square error, will be used as a criterion to numerically compare our results.

  20. Analysis of Functions of Delayed Echolalia in Autistic Children.

    Science.gov (United States)

    Prizant, Barry M.; Rydell, Patrick J.

    1984-01-01

    Fourteen functional categories of delayed echolalia in three autistic children (4-14 years old) were derived from videotape analyses. Individual differences in functional usage were apparent across Ss. Delayed echolalia varied along the dimensions of interactiveness, comprehension of the utterance produced, and relevance to linguistic or…

  1. Functional analysis of three plasmids from Lactobacillus plantarum

    NARCIS (Netherlands)

    Kranenburg, R. van; Golic, N.; Bongers, R.; Leer, R.J.; Vos, W.M. de; Siezen, R.J.; Kleerebezem, M.

    2005-01-01

    Lactobacillus plantarum WCFS1 harbors three plasmids, pWCFS101, pWCFS102, and pWCFS103, with sizes of 1,917, 2,365, and 36,069 bp, respectively. The two smaller plasmids are of unknown function and contain replication genes that are likely to function via the rolling-circle replication mechanism.

  2. Novel axolotl cardiac function analysis method using magnetic resonance imaging

    NARCIS (Netherlands)

    Sanches, Pedro Gomes; Op 't Veld, Roel C.; de Graaf, Wolter; Strijkers, Gustav J.; Grüll, Holger

    2017-01-01

    The salamander axolotl is capable of complete regeneration of amputated heart tissue. However, non-invasive imaging tools for assessing its cardiac function were so far not employed. In this study, cardiac magnetic resonance imaging is introduced as a non-invasive technique to image heart function

  3. Novel axolotl cardiac function analysis method using magnetic resonance imaging

    NARCIS (Netherlands)

    Sanches, P.G.; Op ‘t Veld, R.C.; de Graaf, W.; Strijkers, G.J.; Grüll, H.

    2017-01-01

    The salamander axolotl is capable of complete regeneration of amputated heart tissue. However, non-invasive imaging tools for assessing its cardiac function were so far not employed. In this study, cardiac magnetic resonance imaging is introduced as a noninvasive technique to image heart function of

  4. Classroom Application of a Trial-Based Functional Analysis

    Science.gov (United States)

    Bloom, Sarah E.; Iwata, Brian A.; Fritz, Jennifer N.; Roscoe, Eileen M.; Carreau, Abbey B.

    2011-01-01

    We evaluated a trial-based approach to conducting functional analyses in classroom settings. Ten students referred for problem behavior were exposed to a series of assessment trials, which were interspersed among classroom activities throughout the day. Results of these trial-based functional analyses were compared to those of more traditional…

  5. Compilation of functional languages using flow graph analysis

    NARCIS (Netherlands)

    Hartel, Pieter H.; Glaser, Hugh; Wild, John M.

    A system based on the notion of a flow graph is used to specify formally and to implement a compiler for a lazy functional language. The compiler takes a simple functional language as input and generates C. The generated C program can then be compiled, and loaded with an extensive run-time system to

  6. Optimization of functionalization conditions for protein analysis by AFM

    Energy Technology Data Exchange (ETDEWEB)

    Arroyo-Hernández, María, E-mail: maria.arroyo@ctb.upm.es [Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, 28223 Pozuelo de Alarcón, Madrid (Spain); Departamento de Ciencia de Materiales, ETSI Caminos, Canales y Puertos, Universidad Politécnica de Madrid, 28040 Madrid (Spain); Daza, Rafael; Pérez-Rigueiro, Jose; Elices, Manuel; Nieto-Márquez, Jorge; Guinea, Gustavo V. [Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, 28223 Pozuelo de Alarcón, Madrid (Spain); Departamento de Ciencia de Materiales, ETSI Caminos, Canales y Puertos, Universidad Politécnica de Madrid, 28040 Madrid (Spain)

    2014-10-30

    Highlights: • Highest fluorescence is obtained for central conditions. • Largest primary amine contribution is obtained for central conditions. • RMS roughness is smaller than 1 nm for all functional films. • Selected deposition conditions lead to proper RMS and functionality values. • LDH proteins adsorbed on AVS-films were observed by AFM. - Abstract: Activated vapor silanization (AVS) is used to functionalize silicon surfaces through deposition of amine-containing thin films. AVS combines vapor silanization and chemical vapor deposition techniques and allows the properties of the functionalized layers (thickness, amine concentration and topography) to be controlled by tuning the deposition conditions. An accurate characterization is performed to correlate the deposition conditions and functional-film properties. In particular, it is shown that smooth surfaces with a sufficient surface density of amine groups may be obtained with this technique. These surfaces are suitable for the study of proteins with atomic force microscopy.

  7. A Temporal Extension to Traditional Empirical Orthogonal Function Analysis

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Hilger, Klaus Baggesen; Andersen, Ole Baltazar

    2002-01-01

    (EOF) analysis, which provides a non-temporal analysis of one variable over time. The temporal extension proves its strength in separating the signals at different periods in an analysis of relevant oceanographic properties related to one of the largest El Niño events ever recorded....

  8. Extension problem for generalized multi-monogenic functions in Clifford analysis

    International Nuclear Information System (INIS)

    Tran Quyet Thang.

    1992-10-01

    The main purpose of this paper is to extend some properties of multi-monogenic functions, which is a generalization of monogenic functions in higher dimensions, for a class of functions satisfying Vekua-type generalized Cauchy-Riemann equations in Clifford Analysis. It is proved that the Hartogs theorem is valid for these functions. (author). 7 refs

  9. A Review of Functional Analysis Methods Conducted in Public School Classroom Settings

    Science.gov (United States)

    Lloyd, Blair P.; Weaver, Emily S.; Staubitz, Johanna L.

    2016-01-01

    The use of functional behavior assessments (FBAs) to address problem behavior in classroom settings has increased as a result of education legislation and long-standing evidence supporting function-based interventions. Although functional analysis remains the standard for identifying behavior--environment functional relations, this component is…

  10. The analysis of gastric function using computational techniques

    International Nuclear Information System (INIS)

    Young, Paul

    2002-01-01

    The work presented in this thesis was carried out at the Magnetic Resonance Centre, Department of Physics and Astronomy, University of Nottingham, between October 1996 and June 2000. This thesis describes the application of computerised techniques to the analysis of gastric function, in relation to Magnetic Resonance Imaging data. The implementation of a computer program enabling the measurement of motility in the lower stomach is described in Chapter 6. This method allowed the dimensional reduction of multi-slice image data sets into a 'Motility Plot', from which the motility parameters - the frequency, velocity and depth of contractions - could be measured. The technique was found to be simple, accurate and involved substantial time savings, when compared to manual analysis. The program was subsequently used in the measurement of motility in three separate studies, described in Chapter 7. In Study 1, four different meal types of varying viscosity and nutrient value were consumed by 12 volunteers. The aim of the study was (i) to assess the feasibility of using the motility program in a volunteer study and (ii) to determine the effects of the meals on motility. The results showed that the parameters were remarkably consistent between the 4 meals. However, for each meal, velocity and percentage occlusion were found to increase as contractions propagated along the antrum. The first clinical application of the motility program was carried out in Study 2. Motility from three patients was measured, after they had been referred to the Magnetic Resonance Centre with gastric problems. The results showed that one of the patients displayed an irregular motility, compared to the results of the volunteer study. This result had not been observed using other investigative techniques. In Study 3, motility was measured in Low Viscosity and High Viscosity liquid/solid meals, with the solid particulate consisting of agar beads of varying breakdown strength. The results showed that

  11. Regional sensitivity analysis using revised mean and variance ratio functions

    International Nuclear Information System (INIS)

    Wei, Pengfei; Lu, Zhenzhou; Ruan, Wenbin; Song, Jingwen

    2014-01-01

    The variance ratio function, derived from the contribution to sample variance (CSV) plot, is a regional sensitivity index for studying how much the output deviates from the original mean of model output when the distribution range of one input is reduced and to measure the contribution of different distribution ranges of each input to the variance of model output. In this paper, the revised mean and variance ratio functions are developed for quantifying the actual change of the model output mean and variance, respectively, when one reduces the range of one input. The connection between the revised variance ratio function and the original one is derived and discussed. It is shown that compared with the classical variance ratio function, the revised one is more suitable to the evaluation of model output variance due to reduced ranges of model inputs. A Monte Carlo procedure, which needs only a set of samples for implementing it, is developed for efficiently computing the revised mean and variance ratio functions. The revised mean and variance ratio functions are compared with the classical ones by using the Ishigami function. At last, they are applied to a planar 10-bar structure

  12. Robustness of Multiple Objective Decision Analysis Preference Functions

    National Research Council Canada - National Science Library

    Klimack, William

    2002-01-01

    .... The impact of these differences was examined to improve implementation efficiency. The robustness of the decision model was examined with respect to the preference functions to reduce the time burden imposed on the decision maker...

  13. Analysis of the Changing Functional Structure of Major Urban ...

    African Journals Online (AJOL)

    user

    Changes in Urban Functional Structure in Ethiopia. EJBE Vol. ... primary engines of economic growth, social wellbeing, centers of creativity, innovation and ... economic as well as commercial and business activities were confined to the capital ...

  14. Stress analysis in a functionally graded disc under mechanical loads ...

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana; Volume 36; Issue 1 ... Infinitesimal deformation theory of elasticity and power law distribution for functional ... are presented due to internal pressure, external pressure, centrifugal force and steady state temperature.

  15. Minkowski Functionals and Cluster Analysis for CMB Maps

    Science.gov (United States)

    Novikov, D.; Feldman, Hume A.; Shandarin, Sergei F.

    We suggest novel statistics for the CMB maps that are sensitive to non-Gaussian features. These statistics are natural generalizations of the geometrical and topological methods that have been already used in cosmology such as the cumulative distribution function and genus. We compute the distribution functions of the Partial Minkowski Functionals for the excursion set above or bellow a constant temperature threshold. Minkowski Functionals are additive and are translationally and rotationally invariant. Thus, they can be used for patchy and/or incomplete coverage. The technique is highly efficient computationally (it requires only O(N) operations, where N is the number of pixels per one threshold level). Further, the procedure makes it possible to split large data sets into smaller subsets. The full advantage of these statistics can be obtained only on very large data sets. We apply it to the 4-year DMR COBE data corrected for the Galaxy contamination as an illustration of the technique.

  16. Analysis on functions of mobile nuclear emergency monitoring lab

    International Nuclear Information System (INIS)

    Lai Yongfang; Wang Yonghong; Gao Jing; Sun Jian

    2012-01-01

    According to the fundamental purpose and mission of nuclear emergency monitoring and based on technological aspects, this paper discusses and analyses the functions and basic requirements on equipment in mobile radiation measurement lab in nuclear emergency response. (authors)

  17. Functional analysis of thermostable proteins involved in carbohydrate metabolism

    NARCIS (Netherlands)

    Akerboom, A.P.

    2007-01-01

    Thermostable proteins can resist temperature stress whilst keeping their integrity and functionality. In many cases, thermostable proteins originate from hyperthermophilic microorganisms that thrive in extreme environments. These systems are generally located close to geothermal (volcanic) activity,

  18. Restoration and functional analysis of nuclear medicine images

    International Nuclear Information System (INIS)

    Wendt, R.E. III.

    1982-01-01

    The nuclear medicine physician uses visual interpretation of a movie-like display of the beating human heart to detect wall motion abnormalities which might be related to impaired cardiac function. The present work is directed toward extracting more information from the heart motion study, and presenting it in a useful manner. A spatially adaptive smoothing routine using a quadtree image representation gives an improvement in mean squared error compared to the S9 smoother commonly used for nuclear medicine studies. Functional images show the two-dimensional distribution of parameters of the heart motion. The most popular, the first harmonic phase functional image, formed from the first Fourier harmonic fit to each pixel time-activity curve, is subject to significant artifacts which make a simple interpretation of it difficult. A multi-harmonic approximation is more accurate and offers a wealth of unique parameters with which to construct more directly meaningful functional images

  19. Tucker Tensor analysis of Matern functions in spatial statistics

    KAUST Repository

    Litvinenko, Alexander; Keyes, David E.; Khoromskaia, Venera; Khoromskij, Boris N.; Matthies, Hermann G.

    2018-01-01

    in a low-rank tensor format. We apply the Tucker and canonical tensor decompositions to a family of Matern- and Slater-type functions with varying parameters and demonstrate numerically that their approximations exhibit exponentially fast convergence

  20. Dynamic Analysis of Money Demand Function: Case of Turkey*

    OpenAIRE

    doğru, bülent

    2013-01-01

    In this paper, the dynamic determinants of money demand function and the long-run and short-run relationships between money demand, income and nominal interest rates are examined in Turkey for the time period 1980-2012. In particular we estimate a dynamic specification of a log money demand function based on Keynesian liquidity preference theory to ascertain the relevant elasticity of money demand. The empirical results of the study show that in Turkey inflation, exchange rate and money deman...

  1. Comprehensive functional analysis of Rab GTPases in Drosophila nephrocytes.

    Science.gov (United States)

    Fu, Yulong; Zhu, Jun-Yi; Zhang, Fujian; Richman, Adam; Zhao, Zhanzheng; Han, Zhe

    2017-06-01

    The Drosophila nephrocyte is a critical component of the fly renal system and bears structural and functional homology to podocytes and proximal tubule cells of the mammalian kidney. Investigations of nephrocyte cell biological processes are fundamental to understanding the insect renal system. Nephrocytes are highly active in endocytosis and vesicle trafficking. Rab GTPases regulate endocytosis and trafficking but specific functions of nephrocyte Rabs remain undefined. We analyzed Rab GTPase expression and function in Drosophila nephrocytes and found that 11 out of 27 Drosophila Rabs were required for normal activity. Rabs 1, 5, 7, 11 and 35 were most important. Gene silencing of the nephrocyte-specific Rab5 eliminated all intracellular vesicles and the specialized plasma membrane structures essential for nephrocyte function. Rab7 silencing dramatically increased clear vacuoles and reduced lysosomes. Rab11 silencing increased lysosomes and reduced clear vacuoles. Our results suggest that Rab5 mediates endocytosis that is essential for the maintenance of functionally critical nephrocyte plasma membrane structures and that Rabs 7 and 11 mediate alternative downstream vesicle trafficking pathways leading to protein degradation and membrane recycling, respectively. Elucidating molecular pathways underlying nephrocyte function has the potential to yield important insights into human kidney cell physiology and mechanisms of cell injury that lead to disease. The Drosophila nephrocyte is emerging as a useful in vivo model system for molecular target identification and initial testing of therapeutic approaches in humans.

  2. A Bivariate Extension to Traditional Empirical Orthogonal Function Analysis

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Hilger, Klaus Baggesen; Andersen, Ole Baltazar

    2002-01-01

    This paper describes the application of canonical correlations analysis to the joint analysis of global monthly mean values of 1996-1997 sea surface temperature (SST) and height (SSH) data. The SST data are considered as one set and the SSH data as another set of multivariate observations, both w...... as for example an increase in the SST will lead to an increase in the SSH. The analysis clearly shows the build-up of one of the largest El Niño events on record. Also the analysis indicates a phase lag of approximately one month between the SST and SSH fields....

  3. FMAP: Functional Mapping and Analysis Pipeline for metagenomics and metatranscriptomics studies.

    Science.gov (United States)

    Kim, Jiwoong; Kim, Min Soo; Koh, Andrew Y; Xie, Yang; Zhan, Xiaowei

    2016-10-10

    Given the lack of a complete and comprehensive library of microbial reference genomes, determining the functional profile of diverse microbial communities is challenging. The available functional analysis pipelines lack several key features: (i) an integrated alignment tool, (ii) operon-level analysis, and (iii) the ability to process large datasets. Here we introduce our open-sourced, stand-alone functional analysis pipeline for analyzing whole metagenomic and metatranscriptomic sequencing data, FMAP (Functional Mapping and Analysis Pipeline). FMAP performs alignment, gene family abundance calculations, and statistical analysis (three levels of analyses are provided: differentially-abundant genes, operons and pathways). The resulting output can be easily visualized with heatmaps and functional pathway diagrams. FMAP functional predictions are consistent with currently available functional analysis pipelines. FMAP is a comprehensive tool for providing functional analysis of metagenomic/metatranscriptomic sequencing data. With the added features of integrated alignment, operon-level analysis, and the ability to process large datasets, FMAP will be a valuable addition to the currently available functional analysis toolbox. We believe that this software will be of great value to the wider biology and bioinformatics communities.

  4. Analysis of Uncertainty in Dynamic Processes Development of Banks Functioning

    Directory of Open Access Journals (Sweden)

    Aleksei V. Korovyakovskii

    2013-01-01

    Full Text Available The paper offers the approach to measure of uncertainty estimation in dynamic processes of banks functioning, using statistic data of different banking operations indicators. To calculate measure of uncertainty in dynamic processes of banks functioning the phase images of relevant sets of statistic data are considered. Besides, it is shown that the form of phase image of the studied sets of statistic data can act as a basis of measure of uncertainty estimation in dynamic processes of banks functioning. The set of analytical characteristics are offered to formalize the form of phase image definition of the studied sets of statistic data. It is shown that the offered analytical characteristics consider inequality of changes in values of the studied sets of statistic data, which is one of the ways of uncertainty display in dynamic processes development. The invariant estimates of measure of uncertainty in dynamic processes of banks functioning, considering significant changes in absolute values of the same indicators for different banks were obtained. The examples of calculation of measure of uncertainty in dynamic processes of concrete banks functioning were cited.

  5. Structural and functional analysis of multi-interface domains.

    Directory of Open Access Journals (Sweden)

    Liang Zhao

    Full Text Available A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contact with many other domains, forming a hub in domain-domain interaction networks. The functions played by the multiple interfaces are usually different, but there is no strict bijection between the functions and interfaces as some subsets of the interfaces play the same function. This work applies graph theory and algorithms to discover fingerprints for the multiple interfaces of a domain and to establish associations between the interfaces and functions, based on a huge set of multi-interface proteins from PDB. We found that about 40% of proteins have the multi-interface property, however the involved multi-interface domains account for only a tiny fraction (1.8% of the total number of domains. The interfaces of these domains are distinguishable in terms of their fingerprints, indicating the functional specificity of the multiple interfaces in a domain. Furthermore, we observed that both cooperative and distinctive structural patterns, which will be useful for protein engineering, exist in the multiple interfaces of a domain.

  6. MHD stability analysis using higher order spline functions

    Energy Technology Data Exchange (ETDEWEB)

    Ida, Akihiro [Department of Energy Engineering and Science, Graduate School of Engineering, Nagoya University, Nagoya, Aichi (Japan); Todoroki, Jiro; Sanuki, Heiji

    1999-04-01

    The eigenvalue problem of the linearized magnetohydrodynamic (MHD) equation is formulated by using higher order spline functions as the base functions of Ritz-Galerkin approximation. When the displacement vector normal to the magnetic surface (in the magnetic surface) is interpolated by B-spline functions of degree p{sub 1} (degree p{sub 2}), which is continuously c{sub 1}-th (c{sub 2}-th) differentiable on neighboring finite elements, the sufficient conditions for the good approximation is given by p{sub 1}{>=}p{sub 2}+1, c{sub 1}{<=}c{sub 2}+1, (c{sub 1}{>=}1, p{sub 2}{>=}c{sub 2}{>=}0). The influence of the numerical integration upon the convergence of calculated eigenvalues is discussed. (author)

  7. Functional analysis of lysosomes during mouse preimplantation embryo development.

    Science.gov (United States)

    Tsukamoto, Satoshi; Hara, Taichi; Yamamoto, Atsushi; Ohta, Yuki; Wada, Ayako; Ishida, Yuka; Kito, Seiji; Nishikawa, Tetsu; Minami, Naojiro; Sato, Ken; Kokubo, Toshiaki

    2013-01-01

    Lysosomes are acidic and highly dynamic organelles that are essential for macromolecule degradation and many other cellular functions. However, little is known about lysosomal function during early embryogenesis. Here, we found that the number of lysosomes increased after fertilization. Lysosomes were abundant during mouse preimplantation development until the morula stage, but their numbers decreased slightly in blastocysts. Consistently, the protein expression level of mature cathepsins B and D was high from the one-cell to morula stages but low in the blastocyst stage. One-cell embryos injected with siRNAs targeted to both lysosome-associated membrane protein 1 and 2 (LAMP1 and LAMP2) were developmentally arrested at the two-cell stage. Pharmacological inhibition of lysosomes also caused developmental retardation, resulting in accumulation of lipofuscin. Our findings highlight the functional changes in lysosomes in mouse preimplantation embryos.

  8. Functional Analysis of Chk2-Kiaa0170 Interaction

    Science.gov (United States)

    2006-09-01

    Biology ( Human Press) : Use of siRNA to study the function of MDC1 in DNA damage responses. Methods in Molecular Biology, 281(2): 179-187. Humana...male infertility phenotype has also been reported in ATM2/2 and H2AX2/2 animals, albeit due to distinctive defects during meiosis (Barlow et al., 1996...suggest that MDC1 functions in DSB repair. Failure to repair DNA damage is linked to genomic in - stability. The observed defects in meiosis , class switch

  9. Functional analysis of Ficolin-3 mediated complement activation

    DEFF Research Database (Denmark)

    Hein, Estrid; Honoré, Christian; Skjoedt, Mikkel-Ole

    2010-01-01

    Ficolin-3 mediated complement activation that could be applicable for research and clinical use. Bovine serum albumin (BSA) was acetylated (acBSA) and chosen as a solid phase ligand for Ficolins in microtiter wells. Binding of Ficolins on acBSA was evaluated, as was functional complement activation...... was applied to the samples that inhibited interference from the classical pathway due to the presence of anti-BSA antibodies in some sera. We describe a novel functional method for measuring complement activation mediated by Ficolin-3 in human serum up to the formation of TCC. The assay provides...

  10. An assessment of functioning and non-functioning distractors in multiple-choice questions: a descriptive analysis

    Directory of Open Access Journals (Sweden)

    Mohammed Ahmed M

    2009-07-01

    Full Text Available Abstract Background Four- or five-option multiple choice questions (MCQs are the standard in health-science disciplines, both on certification-level examinations and on in-house developed tests. Previous research has shown, however, that few MCQs have three or four functioning distractors. The purpose of this study was to investigate non-functioning distractors in teacher-developed tests in one nursing program in an English-language university in Hong Kong. Methods Using item-analysis data, we assessed the proportion of non-functioning distractors on a sample of seven test papers administered to undergraduate nursing students. A total of 514 items were reviewed, including 2056 options (1542 distractors and 514 correct responses. Non-functioning options were defined as ones that were chosen by fewer than 5% of examinees and those with a positive option discrimination statistic. Results The proportion of items containing 0, 1, 2, and 3 functioning distractors was 12.3%, 34.8%, 39.1%, and 13.8% respectively. Overall, items contained an average of 1.54 (SD = 0.88 functioning distractors. Only 52.2% (n = 805 of all distractors were functioning effectively and 10.2% (n = 158 had a choice frequency of 0. Items with more functioning distractors were more difficult and more discriminating. Conclusion The low frequency of items with three functioning distractors in the four-option items in this study suggests that teachers have difficulty developing plausible distractors for most MCQs. Test items should consist of as many options as is feasible given the item content and the number of plausible distractors; in most cases this would be three. Item analysis results can be used to identify and remove non-functioning distractors from MCQs that have been used in previous tests.

  11. An assessment of functioning and non-functioning distractors in multiple-choice questions: a descriptive analysis.

    Science.gov (United States)

    Tarrant, Marie; Ware, James; Mohammed, Ahmed M

    2009-07-07

    Four- or five-option multiple choice questions (MCQs) are the standard in health-science disciplines, both on certification-level examinations and on in-house developed tests. Previous research has shown, however, that few MCQs have three or four functioning distractors. The purpose of this study was to investigate non-functioning distractors in teacher-developed tests in one nursing program in an English-language university in Hong Kong. Using item-analysis data, we assessed the proportion of non-functioning distractors on a sample of seven test papers administered to undergraduate nursing students. A total of 514 items were reviewed, including 2056 options (1542 distractors and 514 correct responses). Non-functioning options were defined as ones that were chosen by fewer than 5% of examinees and those with a positive option discrimination statistic. The proportion of items containing 0, 1, 2, and 3 functioning distractors was 12.3%, 34.8%, 39.1%, and 13.8% respectively. Overall, items contained an average of 1.54 (SD = 0.88) functioning distractors. Only 52.2% (n = 805) of all distractors were functioning effectively and 10.2% (n = 158) had a choice frequency of 0. Items with more functioning distractors were more difficult and more discriminating. The low frequency of items with three functioning distractors in the four-option items in this study suggests that teachers have difficulty developing plausible distractors for most MCQs. Test items should consist of as many options as is feasible given the item content and the number of plausible distractors; in most cases this would be three. Item analysis results can be used to identify and remove non-functioning distractors from MCQs that have been used in previous tests.

  12. Molecular cloning, characterization and functional analysis of a 3 ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-08-04

    Aug 4, 2009 ... other plant HMGRs and contained 2 transmembrane domains and a catalytic domain. The potential significance ... used as animal feed. Therefore ... Table 1. Primers used in the cloning and analysis of JcHMGR gene. Primers.

  13. Analysis of human cerebral functions using positron emission tomography (PET)

    International Nuclear Information System (INIS)

    Shibasaki, Takashi

    1984-01-01

    Positron emission tomography has two major advantages to analyse human cerebral functions in vivo. First, we can see the distribution of a variety of substance in the living (and doing something) human brain. Positron emitters, 11 C, 13 N, 15 O and 18 F, are made by medical cyclotron and are elements of natural substrates or easily tagged to substrate. Second, the distribution of the tracer is calculated to make a quantitative functional map in a reasonable spatial resolution over the entire brain in the same time. Not only cortical areas but also deeper structures show regional cerebral blood flow (rCBF) or local cerebral metabolic rates (LCMRs). Nowadays, PET is put to practical use for determination of mainly rCBF, LCMR for glucose (LCMRsub(glu)), LCMR for oxygen (LCMRsub(o2)) and regional cerebral blood volume (rCBV). There have been many other pilot studies, such as estimation of distribution of given neurotransmitters or modulators in the brain which also confirms the substances' role in the neuronal function, and observation of protein synthesis relating to memory function. (J.P.N.)

  14. Aggregate Production Function and Income Identity - Empirical Analysis

    Czech Academy of Sciences Publication Activity Database

    Čadil, J.; Vltavská, K.; Krejčí, I.; Hartman, David; Brabec, Marek

    2017-01-01

    Roč. 6, č. 1 (2017), s. 1-17 ISSN 1804-9796 Institutional support: RVO:67985807 Keywords : aggregate production function * income identity * capital services * labour services Subject RIV: BB - Applied Statistics, Operational Research OBOR OECD: Statistics and probability http://www.iises.net/international-journal-of- economic -sciences/publication-detail-1223

  15. Structural and functional analysis of bovine herpesvirus 1 minor glycoproteins

    NARCIS (Netherlands)

    Baranowski, E.; Keil, G.; Lyaku, J.; Rijsewijk, F.A.M.; Oirschot, van J.T.; Pastoret, P.P.; Thiry, E.

    1996-01-01

    This paper focuses on the structure and functions of bovine herpesvirus 1 minor glycoproteins gH, gE, gG and gp42. It reviews the progress which has been made in their identification and characterization, in the study of their temporal expression and processing in infected cells, and finally in the

  16. Chronic job burnout and daily functioning: A theoretical analysis

    NARCIS (Netherlands)

    A.B. Bakker (Arnold); P.L. Costa (Patrícia Lopes)

    2014-01-01

    textabstractIn this article, we discuss the individual employee's role in the development of his/her job burnout. We review the antecedents and consequences of burnout, and propose a model with chronic burnout as a moderator of daily functioning in the workplace. Specifically, we argue that chronic

  17. Tucker tensor analysis of Matern functions in spatial statistics

    KAUST Repository

    Litvinenko, Alexander

    2018-04-20

    Low-rank Tucker tensor methods in spatial statistics 1. Motivation: improve statistical models 2. Motivation: disadvantages of matrices 3. Tools: Tucker tensor format 4. Tensor approximation of Matern covariance function via FFT 5. Typical statistical operations in Tucker tensor format 6. Numerical experiments

  18. A Model for Teaching Literary Analysis Using Systemic Functional Grammar

    Science.gov (United States)

    McCrocklin, Shannon; Slater, Tammy

    2017-01-01

    This article introduces an approach that middle-school teachers can follow to help their students carry out linguistic-based literary analyses. As an example, it draws on Systemic Functional Grammar (SFG) to show how J.K. Rowling used language to characterize Hermione as an intelligent female in "Harry Potter and the Deathly Hallows."…

  19. Domain-oriented functional analysis based on expression profiling

    Directory of Open Access Journals (Sweden)

    Greene Jonathan

    2002-10-01

    Full Text Available Abstract Background Co-regulation of genes may imply involvement in similar biological processes or related function. Many clusters of co-regulated genes have been identified using microarray experiments. In this study, we examined co-regulated gene families using large-scale cDNA microarray experiments on the human transcriptome. Results We present a simple model, which, for each probe pair, distills expression changes into binary digits and summarizes the expression of multiple members of a gene family as the Family Regulation Ratio. The set of Family Regulation Ratios for each protein family across multiple experiments is called a Family Regulation Profile. We analyzed these Family Regulation Profiles using Pearson Correlation Coefficients and derived a network diagram portraying relationships between the Family Regulation Profiles of gene families that are well represented on the microarrays. Our strategy was cross-validated with two randomly chosen data subsets and was proven to be a reliable approach. Conclusion This work will help us to understand and identify the functional relationships between gene families and the regulatory pathways in which each family is involved. Concepts presented here may be useful for objective clustering of protein functions and deriving a comprehensive protein interaction map. Functional genomic approaches such as this may also be applicable to the elucidation of complex genetic regulatory networks.

  20. Mutational Analysis of Drosophila Basigin Function in the Visual System

    Science.gov (United States)

    Munro, Michelle; Akkam, Yazan; Curtin, Kathryn D.

    2009-01-01

    Drosophila basigin is a cell-surface glycoprotein of the Ig superfamily and a member of a protein family that includes mammalian EMMPRIN/CD147/basigin, neuroplastin, and embigin. Our previous work on Drosophila basigin has shown that it is required for normal photoreceptor cell structure and normal neuron-glia interaction in the fly visual system. Specifically, the photoreceptor neurons of mosaic animals that are mutant in the eye for basigin show altered cell structure with nuclei, mitochondria and rER misplaced and variable axon diameter compared to wild-type. In addition, glia cells in the optic lamina that contact photoreceptor axons are misplaced and show altered structure. All these defects are rescued by expression of either transgenic fly basigin or transgenic mouse basigin in the photoreceptors demonstrating that mouse basigin can functionally replace fly basigin. To determine what regions of the basigin protein are required for each of these functions, we have created mutant basigin transgenes coding for proteins that are altered in conserved residues, introduced these into the fly genome, and tested them for their ability to rescue both photoreceptor cell structure defects and neuron-glia interaction defects of basigin. The results suggest that the highly conserved transmembrane domain and the extracellular domains are crucial for basigin function in the visual system while the short intracellular tail may not play a role in these functions. PMID:19782733

  1. Cloning and functional analysis in transgenic tobacco of a tapetum ...

    African Journals Online (AJOL)

    The 5'-flanking region of 1174 bp upstream of the translation start point (TSP) of a reported Arabidopsis anther-specific gene, Anther7 gene (ATA7), which putatively encodes a protein related to lipid transfer protein, was cloned and functionally analyzed in transgenic tobacco after been fused with β- glucuronidase (GUS) ...

  2. Whole-genome sequence-based analysis of thyroid function

    DEFF Research Database (Denmark)

    Taylor, Peter N.; Porcu, Eleonora; Chew, Shelby

    2015-01-01

    Normal thyroid function is essential for health, but its genetic architecture remains poorly understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4), we analyse whole-genome sequence data from the UK10K project (N = 2,287). Using additional whole-genome seque...

  3. Analysis of feeding function and jaw stability in bedridden elderly.

    Science.gov (United States)

    Tamura, Fumiyo; Mizukami, Miki; Ayano, Rika; Mukai, Yoshiharu

    2002-01-01

    The purpose of this study was to analyze the relationship between jaw stability and the feeding function of 53 bedridden elderly dysphagic patients. Investigations included a questionnaire on daily life activities and meals, oral examinations, functional tests for feeding ability, and assessments of feeding function during the meal. The results of intraoral examination of this patient population for jaw stability revealed that 34.0% of individuals had posterior support for occlusion regardless of whether they had natural teeth or dentures. Thus, the number classified as having mandibular stability (ST) was 18 and that with no mandibular stability (NST) was 35. In a Repetitive Saliva Swallowing Test (RSST), 83.3% of the NST group and 40.0% of the ST group were unable to swallow more than 3 times within 30 seconds. In a water swallowing test, 91.4% of the NST of group was unable to swallow 15 mL of water by a single swallow, while 40.0% of ST group was capable. The results suggest that jaw stabilization by occlusion with the posterior teeth or dental prosthetics is important to feeding function, particularly swallowing.

  4. Functional analysis of the OCA-B promoter.

    Science.gov (United States)

    Stevens, S; Wang, L; Roeder, R G

    2000-06-15

    OCA-B was identified as a B cell-specific coactivator that functions with either Oct-1 or Oct-2 to mediate efficient cell type-specific transcription via the octamer site (ATGCAAAT) both in vivo and in vitro. Mice lacking OCA-B exhibit normal Ag-independent B cell maturation. In contrast, Ag-dependent functions, including production of secondary Ig isotypes and germinal center formation, are greatly affected. To better understand OCA-B expression and, ultimately, the defects observed in the OCA-B knockout mice, we have cloned the OCA-B promoter and examined its function in both transformed and primary B cells. We show here that the OCA-B promoter is developmentally regulated, with activity increasing throughout B cell differentiation. Through physical and functional assays, we have found an activating transcription factor/cAMP response element binding protein binding site (or cAMP response element) that is crucial for OCA-B promoter activity. Furthermore, we demonstrate that IL-4 and anti-CD40 induce both the OCA-B promoter and octamer-dependent promoters, thus implicating OCA-B in B cell signaling events in the nucleus.

  5. Bandwidth Analysis of Functional Interconnects Used as Test Access Mechanism

    NARCIS (Netherlands)

    Van den Berg, A.; Ren, P.; Marinissen, E.J.; Gaydadjiev, G.; Goossens, K.

    2010-01-01

    Test data travels through a System on Chip (SOC) from the chip pins to the Core-Under-Test (CUT) and vice versa via a Test Access Mechanism (TAM). Conventionally, a TAM is implemented using dedicated communication infrastructure. However, also existing functional interconnect, such as a bus or

  6. Bandwidth analysis of functional interconnects used as test access mechanism

    NARCIS (Netherlands)

    Berg, van den Ardy; Ren, P.; Marinissen, Erik Jan; Gaydadjiev, G.N.; Goossens, K.G.W.

    2010-01-01

    Test data travels through a System on Chip (SOC) from the chip pins to the Core-Under-Test (CUT) and vice versa via a Test Access Mechanism (TAM). Conventionally, a TAM is implemented using dedicated communication infrastructure. However, also existing functional interconnect, such as a bus or

  7. Functional analysis of mutant human carnitine acylcarnitine translocases in yeast

    NARCIS (Netherlands)

    IJlst, L.; van Roermund, C. W.; Iacobazzi, V.; Oostheim, W.; Ruiter, J. P.; Williams, J. C.; Palmieri, F.; Wanders, R. J.

    2001-01-01

    Long chain fatty acids are translocated as carnitine esters across the mitochondrial inner membrane by carnitine acylcarnitine translocase (CACT). We report functional studies on the mutant CACT proteins from a severe and a mild patient with CACT deficiency. CACT activities in fibroblasts of both

  8. Intraoperative mapping of language functions: a longitudinal neurolinguistic analysis.

    Science.gov (United States)

    Ilmberger, Josef; Ruge, Maximilian; Kreth, Friedrich-Wilhelm; Briegel, Josef; Reulen, Hans-Juergen; Tonn, Joerg-Christian

    2008-10-01

    This prospective longitudinally designed study was conducted to evaluate language functions pre- and postoperatively in patients who underwent microsurgical treatment of tumors in close proximity to or within language areas and to detect those patients at risk for a postoperative aphasic disturbance. Between 1991 and 2005, 153 awake craniotomies with subsequent cortical mapping of language functions were performed in 149 patients. Language functions were assessed using a standardized test battery. Risk factors were obtained from multivariate logistic regression models. Language mapping was able to be performed in all patients, and complete tumor resection was achieved in 48.4%. Within 21 days after surgery a new language deficit (aphasic disturbance) was observed in 41 (32%) of the 128 cases without preoperative deficits. There were a total of 60 cases involving postoperative aphasic disturbances, including cases both with and without preoperative disturbances. Risk factors for postoperative aphasic disturbance were preoperative aphasia (planguage-positive sites within the tumor (planguage disturbances. A total of 17.6% of all cases demonstrated new postoperative language disturbances after 7 months. Risk factors for persistent aphasic disturbance were increased age (>40 years, planguage-relevant areas intraoperatively, even when they are located within the tumor. New postoperative deficits resolve in the majority of patients, which may be a result of cortical mapping as well as functional reorganization.

  9. Energy density functional analysis of shape coexistence in 44S

    International Nuclear Information System (INIS)

    Li, Z. P.; Yao, J. M.; Vretenar, D.; Nikšić, T.; Meng, J.

    2012-01-01

    The structure of low-energy collective states in the neutron-rich nucleus 44 S is analyzed using a microscopic collective Hamiltonian model based on energy density functionals (EDFs). The calculated triaxial energy map, low-energy spectrum and corresponding probability distributions indicate a coexistence of prolate and oblate shapes in this nucleus.

  10. Driver steering model for closed-loop steering function analysis

    Science.gov (United States)

    Bolia, Pratiksh; Weiskircher, Thomas; Müller, Steffen

    2014-05-01

    In this paper, a two level preview driver steering control model for the use in numerical vehicle dynamics simulation is introduced. The proposed model is composed of cascaded control loops: The outer loop is the path following layer based on potential field framework. The inner loop tries to capture the driver's physical behaviour. The proposed driver model allows easy implementation of different driving situations to simulate a wide range of different driver types, moods and vehicle types. The expediency of the proposed driver model is shown with the help of developed driver steering assist (DSA) function integrated with a conventional series production (Electric Power steering System with rack assist servo unit) system. With the help of the DSA assist function, the driver is prevented from over saturating the front tyre forces and loss of stability and controllability during cornering. The simulation results show different driver reactions caused by the change in the parameters or properties of the proposed driver model if the DSA assist function is activated. Thus, the proposed driver model is useful for the advanced driver steering and vehicle stability assist function evaluation in the early stage of vehicle dynamics handling and stability evaluation.

  11. Analysis of the transfer function for layered piezoelectric ultrasonic sensors

    Directory of Open Access Journals (Sweden)

    E. Gutiérrrez-Reyes

    2017-06-01

    Full Text Available We model theoretically the voltage response to an acoustic pulse of a multilayer system forming a low noise capacitive sensor including a Polyvinylidene Fluoride piezoelectric film. First we model a generic piezoelectric detector consisting of a piezoelectric film between two metallic electrodes that are the responsible to convert the acoustic signal into a voltage signal. Then we calculate the pressure-to-voltage transfer function for a N-layer piezo-electric capacitor detector, allowing to study the effects of the electrode and protective layers thickness in typical layered piezoelectric sensors. The derived transfer function, when multiplied by the Fourier transform of the incident acoustic pulse, gives the voltage electric response in the frequency domain. An important concern regarding the transfer function is that it may have zeros at specific frequencies, and thus inverting the voltage Fourier transform of the pulse to recover the pressure signal in the time domain is not always, in principle, possible. Our formulas can be used to predict the existence and locations of such zeroes. We illustrate the use of the transfer function by predicting the electric signal generated at a multilayer piezoelectric sensor to an ultrasonic pulse generated photoacoustically by a laser pulse at a three media system with impedance mismatch. This theoretical calculations are compared with our own experimental measurements.

  12. Geometrically non linear analysis of functionally graded material ...

    African Journals Online (AJOL)

    user

    when compared to the other engineering materials (Akhavan and Hamed, 2010). However, FGM plates under mechanical loading may undergo elastic instability. Hence, the non-linear behavior of functionally graded plates has to be understood for their optimum design. Reddy (2000) proposed the theoretical formulation ...

  13. Functional and Genetic Analysis of Choroid Plexus Development in Zebrafish

    Directory of Open Access Journals (Sweden)

    Hannah Elizabeth Henson

    2014-11-01

    Full Text Available The choroid plexus, an epithelial-based structure localized in the brain ventricle, is the major component of the blood-cerebrospinal fluid barrier. The choroid plexus produces the cerebrospinal fluid and regulates the components of the cerebrospinal fluid. Abnormal choroid plexus function is associated with neurodegenerative diseases, tumor formation in the choroid plexus epithelium, and hydrocephaly. In this study, we used zebrafish (Danio rerio as a model system to understand the genetic components of choroid plexus development. We generated an enhancer trap line, Et(cp:EGFPsj2, that expresses enhanced green fluorescent protein (EGFP in the choroid plexus epithelium. Using immunohistochemistry and fluorescent tracers, we demonstrated that the zebrafish choroid plexus possesses brain barrier properties such as tight junctions and transporter activity. Thus, we have established zebrafish as a functionally relevant model to study choroid plexus development. Using an unbiased approach, we performed a forward genetic dissection of the choroid plexus to identify genes essential for its formation and function. Using Et(cp:EGFPsj2, we isolated 10 recessive mutant lines with choroid plexus abnormalities, which were grouped into five classes based on GFP intensity, epithelial localization, and overall choroid plexus morphology. We also mapped the mutation for two mutant lines to chromosomes 4 and 21, respectively. The mutants generated in this study can be used to elucidate specific genes and signaling pathways essential for choroid plexus development, function, and/or maintenance and will provide important insights into how these genetic mutations contribute to disease.

  14. A functional-pragmatic analysis of conversation management ...

    African Journals Online (AJOL)

    Nonetheless, they have a communicative function and their role of giving the conversations a structure by encoding the emotive aspects of interpersonal interaction are of a pragmatic nature, hence their interpretation is derived from the contexts in which they are applied. They regulate the structure of the conversations by ...

  15. Bidirectional reflectance distribution function measurements and analysis of retroreflective materials.

    Science.gov (United States)

    Belcour, Laurent; Pacanowski, Romain; Delahaie, Marion; Laville-Geay, Aude; Eupherte, Laure

    2014-12-01

    We compare the performance of various analytical retroreflecting bidirectional reflectance distribution function (BRDF) models to assess how they reproduce accurately measured data of retroreflecting materials. We introduce a new parametrization, the back vector parametrization, to analyze retroreflecting data, and we show that this parametrization better preserves the isotropy of data. Furthermore, we update existing BRDF models to improve the representation of retroreflective data.

  16. Analysis of vocal and swallowing functions after horizontal glottectomy.

    Science.gov (United States)

    Topaloğlu, İlhan; Bal, Muhlis; Salturk, Ziya; Berkiten, Güler; Atar, Yavuz

    2016-08-01

    We conducted a cross-sectional study to assess vocal and swallowing functions after horizontal glottectomy. Our study population was made up of 22 men aged 45 to 72 years (mean: 58.3) who underwent horizontal glottectomy and completed at least 1 year of follow-up. To compare postoperative results, 20 similarly aged men were included as a control group; all glottectomy patients and all controls were smokers. We used three methods-acoustic and aerodynamic voice analyses, the GRBAS (grade, roughness, breathiness, asthenicity, and strain) scale, and the voice handicap index-30 (VHI-30)-to assess vocal function objectively, perceptually, and subjectively, respectively. We also assessed swallowing function objectively by fiberoptic endoscopic evaluation of swallowing (FEES) and subjectively with the M.D. Anderson dysphagia inventory (MDADI). The 22 patients were also subcategorized into three groups according to the extent of their arytenoid cartilage resection, and their outcomes were compared. Acoustic and aerodynamic analyses showed that the mean maximum phonation time was significantly shorter and the fundamental frequency was significantly lower in the glottectomy group than in the controls (p = 0.001 for both), and that the mean jitter and shimmer values and the mean harmonics-to-noise ratio were all significantly higher (p = 0.001 for all); there were no significant differences among the three arytenoid subgroups. Self-assessments revealed that there were no statistically significant differences among the three subgroups in GRBAS scale scores except for the breathiness score (p = 0.045), which was lower in the arytenoid preservation subgroup than in the total resection subgroup; there were no statistically significant differences among the three subgroups in VHI-30 scores. Finally, swallow testing found no statistically significant differences in FEES scores or MDADI scores. We conclude that horizontal glottectomy caused a deterioration in vocal function, but

  17. Analysis of the proton longitudinal structure function from the gluon distribution function

    International Nuclear Information System (INIS)

    Boroun, G.R.; Rezaei, B.

    2012-01-01

    We make a critical, next-to-leading order, study of the relationship between the longitudinal structure function F L and the gluon distribution proposed in Cooper-Sarkar et al. (Z. Phys. C 39:281, 1988; Acta Phys. Pol. B 34:2911 2003), which is frequently used to extract the gluon distribution from the proton longitudinal structure function at small x. The gluon density is obtained by expanding at particular choices of the point of expansion and compared with the hard Pomeron behavior for the gluon density. Comparisons with H1 data are made and predictions for the proposed best approach are also provided. (orig.)

  18. A Comparison of Functional Behavior Assessment Methodologies with Young Children: Descriptive Methods and Functional Analysis

    Science.gov (United States)

    Alter, Peter J.; Conroy, Maureen A.; Mancil, G. Rich; Haydon, Todd

    2008-01-01

    The use of functional behavior assessment (FBA) to guide the development of behavior intervention plans continues to increase since they were first mandated in IDEA (Individuals with Disabilities Education Act Amendments of 1997, 20 U.S.C. Section 1400 et seq, 1997). A variety of indirect and direct instruments have been developed to facilitate…

  19. Complex analysis fundamentals of the classical theory of functions

    CERN Document Server

    Stalker, John

    1998-01-01

    This clear, concise introduction to the classical theory of one complex variable is based on the premise that "anything worth doing is worth doing with interesting examples." The content is driven by techniques and examples rather than definitions and theorems. This self-contained monograph is an excellent resource for a self-study guide and should appeal to a broad audience. The only prerequisite is a standard calculus course. The first chapter deals with a beautiful presentation of special functions. . . . The third chapter covers elliptic and modular functions. . . in much more detail, and from a different point of view, than one can find in standard introductory books. . . . For [the] subjects that are omitted, the author has suggested some excellent references for the reader who wants to go through these topics. The book is read easily and with great interest. It can be recommended to both students as a textbook and to mathematicians and physicists as a useful reference. ---Mathematical Reviews Mainly or...

  20. Generating functional analysis of minority games with real market histories

    International Nuclear Information System (INIS)

    Coolen, A C C

    2005-01-01

    It is shown how the generating functional method of De Dominicis can be used to solve the dynamics of the original version of the minority game (MG), in which agents observe real as opposed to fake market histories. Here one again finds exact closed equations for correlation and response functions, but now these are defined in terms of two connected effective non-Markovian stochastic processes: a single effective agent equation similar to that of the 'fake' history models, and a second effective equation for the overall market bid itself (the latter is absent in 'fake' history models). The result is an exact theory, from which one can calculate from first principles both the persistent observables in the MG and the distribution of history frequencies

  1. Vibration analysis of a functionally graded piezoelectric cylindrical actuator

    International Nuclear Information System (INIS)

    Zhang, T T; Shi, Z F; Spencer, B F Jr

    2008-01-01

    This paper focuses on the response of a functionally graded piezoelectric cylindrical actuator placed in a harmonic electric field based on elastic membrane theory and shell theory. The actuator is polarized in the radial direction with its piezoelectric coefficient d 31 varying linearly along the axial direction. In the present investigation, non-dimensional expressions are introduced, and analytical solutions for this class of actuator are obtained. The results provided in the present study are compared with other investigations, with good agreement being found. The major differences between a functionally graded actuator and an actuator with homogeneous material properties are identified, and the advantages of the former are demonstrated. In the last section of this paper, limitations of membrane theory and shell theory models are discussed

  2. Cardiovascular Risk, Drugs and Erectile Function -A Systematic Analysis

    OpenAIRE

    Baumhäkel , Magnus; Schlimmer , Nils; Kratz , Mario; Hackett , Geoffrey; Jackson , Graham; Böhm , Michael

    2011-01-01

    Abstract Aims Erectile dysfunction is a major problem with an increasing prevalence in cardiovascular high-risk patients due to the association with cardiovascular risk factors. Drugs used for evidenced based treatment of cardiovascular diseases have been reported to decrease erectile function, but possible mechanisms are poorly characterized. Methods MEDLINE, EMBASE and Cochrane Registry search was performed including manuscripts until January 2010. Searching terms are: ...

  3. Correlation Function Analysis of Fiber Networks: Implications for Thermal Conductivity

    Science.gov (United States)

    Martinez-Garcia, Jorge; Braginsky, Leonid; Shklover, Valery; Lawson, John W.

    2011-01-01

    The heat transport in highly porous fiber structures is investigated. The fibers are supposed to be thin, but long, so that the number of the inter-fiber connections along each fiber is large. We show that the effective conductivity of such structures can be found from the correlation length of the two-point correlation function of the local conductivities. Estimation of the parameters, determining the conductivity, from the 2D images of the structures is analyzed.

  4. Toward a functional analysis of private verbal self-regulation.

    OpenAIRE

    Taylor, I; O'Reilly, M F

    1997-01-01

    We developed a methodology, derived from the theoretical literatures on rule-governed behavior and private events, to experimentally investigate the relationship between covert verbal self-regulation and nonverbal behavior. The methodology was designed to assess whether (a) nonverbal behavior was under the control of covert rules and (b) verbal reports of these rules were functionally equivalent to the covert rules that control non-verbal behavior. The research was conducted in the context of...

  5. Influence Function and Robust Variant of Kernel Canonical Correlation Analysis

    OpenAIRE

    Alam, Md. Ashad; Fukumizu, Kenji; Wang, Yu-Ping

    2017-01-01

    Many unsupervised kernel methods rely on the estimation of the kernel covariance operator (kernel CO) or kernel cross-covariance operator (kernel CCO). Both kernel CO and kernel CCO are sensitive to contaminated data, even when bounded positive definite kernels are used. To the best of our knowledge, there are few well-founded robust kernel methods for statistical unsupervised learning. In addition, while the influence function (IF) of an estimator can characterize its robustness, asymptotic ...

  6. Wavelet analysis of MR functional data from the cerebellum

    International Nuclear Information System (INIS)

    Karen, Romero Sánchez; Vásquez Reyes Marcos, A.; González Gómez Dulce, I.; Hernández López, Javier M.; Silvia, Hidalgo Tobón; Pilar, Dies Suarez; Eduardo, Barragán Pérez; Benito, De Celis Alonso

    2014-01-01

    The main goal of this project was to create a computer algorithm based on wavelet analysis of BOLD signals, which automatically diagnosed ADHD using information from resting state MR experiments. Male right handed volunteers (infants with ages between 7 and 11 years old) were studied and compared with age matched controls. Wavelet analysis, which is a mathematical tool used to decompose time series into elementary constituents and detect hidden information, was applied here to the BOLD signal obtained from the cerebellum 8 region of all our volunteers. Statistical differences between the values of the a parameters of wavelet analysis was found and showed significant differences (p<0.02) between groups. This difference might help in the future to distinguish healthy from ADHD patients and therefore diagnose ADHD

  7. Wavelet analysis of MR functional data from the cerebellum

    Energy Technology Data Exchange (ETDEWEB)

    Karen, Romero Sánchez, E-mail: alphacentauri-hp@hotmail.com, E-mail: marcos-vaquezr@hotmail.com, E-mail: isabeldgg@hotmail.com; Vásquez Reyes Marcos, A., E-mail: alphacentauri-hp@hotmail.com, E-mail: marcos-vaquezr@hotmail.com, E-mail: isabeldgg@hotmail.com; González Gómez Dulce, I., E-mail: alphacentauri-hp@hotmail.com, E-mail: marcos-vaquezr@hotmail.com, E-mail: isabeldgg@hotmail.com; Hernández López, Javier M., E-mail: javierh@fcfm.buap.mx [Faculty of Physics and Mathematics, BUAP, Puebla, Pue (Mexico); Silvia, Hidalgo Tobón, E-mail: shidbon@gmail.com [Infant Hospital of Mexico, Federico Gómez, Mexico DF. Mexico and Physics Department, Universidad Autónoma Metropolitana. Iztapalapa, Mexico DF. (Mexico); Pilar, Dies Suarez, E-mail: pilydies@yahoo.com, E-mail: neurodoc@prodigy.net.mx; Eduardo, Barragán Pérez, E-mail: pilydies@yahoo.com, E-mail: neurodoc@prodigy.net.mx [Infant Hospital of Mexico, Federico Gómez, Mexico DF. (Mexico); Benito, De Celis Alonso, E-mail: benileon@yahoo.com [Faculty of Physics and Mathematics, BUAP, Puebla, Pue. Mexico and Foundation for Development Carlos Sigüenza. Puebla, Pue. (Mexico)

    2014-11-07

    The main goal of this project was to create a computer algorithm based on wavelet analysis of BOLD signals, which automatically diagnosed ADHD using information from resting state MR experiments. Male right handed volunteers (infants with ages between 7 and 11 years old) were studied and compared with age matched controls. Wavelet analysis, which is a mathematical tool used to decompose time series into elementary constituents and detect hidden information, was applied here to the BOLD signal obtained from the cerebellum 8 region of all our volunteers. Statistical differences between the values of the a parameters of wavelet analysis was found and showed significant differences (p<0.02) between groups. This difference might help in the future to distinguish healthy from ADHD patients and therefore diagnose ADHD.

  8. Analysis of Spo0M function in Bacillus subtilis.

    Directory of Open Access Journals (Sweden)

    Luz Adriana Vega-Cabrera

    Full Text Available Spo0M has been previously reported as a regulator of sporulation in Bacillus subtilis; however, little is known about the mechanisms through which it participates in sporulation, and there is no information to date that relates this protein to other processes in the bacterium. In this work we present evidence from proteomic, protein-protein interaction, morphological, subcellular localization microscopy and bioinformatics studies which indicate that Spo0M function is not necessarily restricted to sporulation, and point towards its involvement in other stages of the vegetative life cycle. In the current study, we provide evidence that Spo0M interacts with cytoskeletal proteins involved in cell division, which suggest a function additional to that previously described in sporulation. Spo0M expression is not restricted to the transition phase or sporulation; rather, its expression begins during the early stages of growth and Spo0M localization in B. subtilis depends on the bacterial life cycle and could be related to an additional proposed function. This is supported by our discovery of homologs in a broad distribution of bacterial genera, even in non-sporulating species. Our work paves the way for re-evaluation of the role of Spo0M in bacterial cell.

  9. Analysis of competitive power market with constant elasticity function

    International Nuclear Information System (INIS)

    Nguyen, D.H.M.; Wong, K.P.

    2003-01-01

    A solution method, for competitive power markets formulated as a Cournot game, that allows equilibrium to be determined without an explicit model of aggregated demand is presented. The method determines market equilibrium for all feasible demand conditions and thus provides a perspective on the market, independent of representative demand function, that reveals the inherent tendencies of producers in the market. Numerical solutions are determined by use of the new controlled genetic algorithm and constraint handling techniques. The solutions give production and demand elasticity distributions of the market at any feasible equilibrium price and volume. The solution distributions evaluated for the market with unspecified demand functions, were found to be consistent with previous results obtained from markets with specific demand functions. The ability of the new approach to all, and arbitrary, solutions allow specific markets to be examined, as well as very general observations to be made. Generally it was observed that: no inherent price constraint exists; price is more volatile for low volumes and high prices; market dominance and power are unaffected by price; and inelastic demand can give rise to equilibrium with lower price than responsive demand. (Author)

  10. Graph theoretical analysis of EEG functional connectivity during music perception.

    Science.gov (United States)

    Wu, Junjie; Zhang, Junsong; Liu, Chu; Liu, Dongwei; Ding, Xiaojun; Zhou, Changle

    2012-11-05

    The present study evaluated the effect of music on large-scale structure of functional brain networks using graph theoretical concepts. While most studies on music perception used Western music as an acoustic stimulus, Guqin music, representative of Eastern music, was selected for this experiment to increase our knowledge of music perception. Electroencephalography (EEG) was recorded from non-musician volunteers in three conditions: Guqin music, noise and silence backgrounds. Phase coherence was calculated in the alpha band and between all pairs of EEG channels to construct correlation matrices. Each resulting matrix was converted into a weighted graph using a threshold, and two network measures: the clustering coefficient and characteristic path length were calculated. Music perception was found to display a higher level mean phase coherence. Over the whole range of thresholds, the clustering coefficient was larger while listening to music, whereas the path length was smaller. Networks in music background still had a shorter characteristic path length even after the correction for differences in mean synchronization level among background conditions. This topological change indicated a more optimal structure under music perception. Thus, prominent small-world properties are confirmed in functional brain networks. Furthermore, music perception shows an increase of functional connectivity and an enhancement of small-world network organizations. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. Production functions for climate policy modeling. An empirical analysis

    International Nuclear Information System (INIS)

    Van der Werf, Edwin

    2008-01-01

    Quantitative models for climate policy modeling differ in the production structure used and in the sizes of the elasticities of substitution. The empirical foundation for both is generally lacking. This paper estimates the parameters of 2-level CES production functions with capital, labour and energy as inputs, and is the first to systematically compare all nesting structures. Using industry-level data from 12 OECD countries, we find that the nesting structure where capital and labour are combined first, fits the data best, but for most countries and industries we cannot reject that all three inputs can be put into one single nest. These two nesting structures are used by most climate models. However, while several climate policy models use a Cobb-Douglas function for (part of the) production function, we reject elasticities equal to one, in favour of considerably smaller values. Finally we find evidence for factor-specific technological change. With lower elasticities and with factor-specific technological change, some climate policy models may find a bigger effect of endogenous technological change on mitigating the costs of climate policy. (author)

  12. The Lithospheric Structure Beneath Canary Islands from Receiver Function Analysis

    Science.gov (United States)

    Martinez-Arevalo, C.; Mancilla, F.; Helffrich, G. R.; Garcia, A.

    2009-12-01

    The Canary Archipelago is located a few hundred kilometers off the western Moroccan coast, extending 450 km west-to-east. It is composed of seven main islands. All but one have been active in the last million years. The origin of the Canary Islands is not well established and local and regional geology features cannot be completely explained by the current models. The main aim of this study is to provide new data that help us to understand and constrain the archipelago's origin and tectonic evolution. The crustal structure under each station is obtained applying P-receiver function technique to the teleseismic P arrivals recorded by the broadband seismic network installed at the Canary Island by the Instituto Geográfico Nacional (IGN) and two temporary stations (MIDSEA and IRIS). We computed receiver functions using the Extended-Time Multitaper Frequency Domain Cross-Correlation Receiver Function (ET-MTRF) method. The results show that the crust is thicker, around 22 km, in the eastern islands (Fuerteventura and Lanzarote) than in the western ones (El Hierro, La Palma, Tenerife), around 17 km, with the exception of La Gomera island. This island, located in the west, exhibits similar crustal structure to Fuerteventura and Lanzarote. A discontinuity at 70-80 km, possibly the LAB (Lithosphere Asthenosphere Boundary) is clearly observed in all the stations. It appears that Moho depths do not track the LAB discontinuity.

  13. Use of functionalized surfactants in flame atomic analysis: Final technical report

    International Nuclear Information System (INIS)

    Armstrong, D.W.

    1987-01-01

    Research results in the following areas are briefly summarized: basic properties of surfactants, micelles, and cyclodextrins as they relate to chemical analysis; use of functionalized surfactants, micelles, and cyclodextrins in spectroscopic analysis; macromolecular separation theory and mechanism; use of functionalized surfactants and cyclodextrins in separations; capillary work for future coupling of spectroscopic and LC projects

  14. Functional Analysis and Treatment of Aggression Maintained by Preferred Conversational Topics

    Science.gov (United States)

    Roscoe, Eileen M.; Kindle, Arianne E.; Pence, Sacha T.

    2010-01-01

    After an initial functional analysis of a participant's aggression showed unclear outcomes, we conducted preference and reinforcer assessments to identify preferred forms of attention that may maintain problem behavior. Next, we conducted an extended functional analysis that included a modified attention condition. Results showed that the…

  15. Progressing from Identification and Functional Analysis of Precursor Behavior to Treatment of Self-Injurious Behavior

    Science.gov (United States)

    Dracobly, Joseph D.; Smith, Richard G.

    2012-01-01

    This multiple-study experiment evaluated the utility of assessing and treating severe self-injurious behavior (SIB) based on the outcomes of a functional analysis of precursor behavior. In Study 1, a precursor to SIB was identified using descriptive assessment and conditional probability analyses. In Study 2, a functional analysis of precursor…

  16. Functional principal component analysis of glomerular filtration rate curves after kidney transplant.

    Science.gov (United States)

    Dong, Jianghu J; Wang, Liangliang; Gill, Jagbir; Cao, Jiguo

    2017-01-01

    This article is motivated by some longitudinal clinical data of kidney transplant recipients, where kidney function progression is recorded as the estimated glomerular filtration rates at multiple time points post kidney transplantation. We propose to use the functional principal component analysis method to explore the major source of variations of glomerular filtration rate curves. We find that the estimated functional principal component scores can be used to cluster glomerular filtration rate curves. Ordering functional principal component scores can detect abnormal glomerular filtration rate curves. Finally, functional principal component analysis can effectively estimate missing glomerular filtration rate values and predict future glomerular filtration rate values.

  17. Including screening in van der Waals corrected density functional theory calculations: The case of atoms and small molecules physisorbed on graphene

    Energy Technology Data Exchange (ETDEWEB)

    Silvestrelli, Pier Luigi; Ambrosetti, Alberto [Dipartimento di Fisica e Astronomia, Università di Padova, via Marzolo 8, I–35131 Padova, Italy and DEMOCRITOS National Simulation Center of the Italian Istituto Officina dei Materiali (IOM) of the Italian National Research Council (CNR), Trieste (Italy)

    2014-03-28

    The Density Functional Theory (DFT)/van der Waals-Quantum Harmonic Oscillator-Wannier function (vdW-QHO-WF) method, recently developed to include the vdW interactions in approximated DFT by combining the quantum harmonic oscillator model with the maximally localized Wannier function technique, is applied to the cases of atoms and small molecules (X=Ar, CO, H{sub 2}, H{sub 2}O) weakly interacting with benzene and with the ideal planar graphene surface. Comparison is also presented with the results obtained by other DFT vdW-corrected schemes, including PBE+D, vdW-DF, vdW-DF2, rVV10, and by the simpler Local Density Approximation (LDA) and semilocal generalized gradient approximation approaches. While for the X-benzene systems all the considered vdW-corrected schemes perform reasonably well, it turns out that an accurate description of the X-graphene interaction requires a proper treatment of many-body contributions and of short-range screening effects, as demonstrated by adopting an improved version of the DFT/vdW-QHO-WF method. We also comment on the widespread attitude of relying on LDA to get a rough description of weakly interacting systems.

  18. Social Signals, their function, and automatic analysis: A survey

    NARCIS (Netherlands)

    Vinciarelli, Alessandro; Pantic, Maja; Bourlard, Hervé; Pentland, Alex

    2008-01-01

    Social Signal Processing (SSP) aims at the analysis of social behaviour in both Human-Human and Human-Computer interactions. SSP revolves around automatic sensing and interpretation of social signals, complex aggregates of nonverbal behaviours through which individuals express their attitudes

  19. Isolation and preliminary function analysis of a Na + /H + antiporter ...

    African Journals Online (AJOL)

    A full-length cDNA Na+/H+ antiporter gene (MzNHX1) was isolated from Malus zumi according to the homologous Na+/H+ antiporter gene region in plants. Sequence analysis indicated that the cDNA was 2062 bp in length, including an open reading frame (ORF) of 1629 bp, which encoded a predicted polypeptide of 542 ...

  20. Use of linear discriminant function analysis in seed morphotype ...

    African Journals Online (AJOL)

    Variation in seed morphology of the Lima bean in 31 accessions was studied. Data were collected on 100-seed weight, seed length and seed width. The differences among the accessions were significant, based on the three seed characteristics. K-means cluster analysis grouped the 31 accessions into four distinct groups, ...

  1. Use of Linear Discriminant Function Analysis in Five Yield Sub ...

    African Journals Online (AJOL)

    K-means cluster analysis grouped the 134 accessions into four distinct groups. Pairwise Mahalanobis 2 distance (D) among some of the groups was highly significant. From the study the yield sub-characters pod length, pod width, peduncle length and 100-seed weight contributed most to group separation in the cowpea ...

  2. Knowledge-based analysis of functional impacts of mutations in ...

    Indian Academy of Sciences (India)

    2015-09-28

    Sep 28, 2015 ... MicroRNAs are a class of important post-transcriptional regulators. ... In the analysis of a SNP in the seed region of hsa-miR-96 ... pathway' and 'Epidermal growth factor receptor signaling pathway' were significantly and ...

  3. Function spaces and partial differential equations volume 2 : contemporary analysis

    CERN Document Server

    Taheri, Ali

    2015-01-01

    This is a book written primarily for graduate students and early researchers in the fields of Analysis and Partial Differential Equations (PDEs). Coverage of the material is essentially self-contained, extensive and novel with great attention to details and rigour.

  4. Genome-wide identification, functional analysis and expression ...

    African Journals Online (AJOL)

    The plant pleiotropic drug resistance (PDR) family of ATP-binding cassette (ABC) transporters has comprehensively been researched in relation to transport of antifungal agents and resistant pathogens. In our study, analyses of the whole family of PDR genes present in the potato genome were provided. This analysis ...

  5. Data synthesis and display programs for wave distribution function analysis

    Science.gov (United States)

    Storey, L. R. O.; Yeh, K. J.

    1992-01-01

    At the National Space Science Data Center (NSSDC) software was written to synthesize and display artificial data for use in developing the methodology of wave distribution analysis. The software comprises two separate interactive programs, one for data synthesis and the other for data display.

  6. Recent applications of harmonic analysis to function spaces, differential equations, and data science novel methods in harmonic analysis

    CERN Document Server

    Gia, Quoc; Mayeli, Azita; Mhaskar, Hrushikesh; Zhou, Ding-Xuan

    2017-01-01

    The second of a two volume set on novel methods in harmonic analysis, this book draws on a number of original research and survey papers from well-known specialists detailing the latest innovations and recently discovered links between various fields. Along with many deep theoretical results, these volumes contain numerous applications to problems in signal processing, medical imaging, geodesy, statistics, and data science. The chapters within cover an impressive range of ideas from both traditional and modern harmonic analysis, such as: the Fourier transform, Shannon sampling, frames, wavelets, functions on Euclidean spaces, analysis on function spaces of Riemannian and sub-Riemannian manifolds, Fourier analysis on manifolds and Lie groups, analysis on combinatorial graphs, sheaves, co-sheaves, and persistent homologies on topological spaces. Volume II is organized around the theme of recent applications of harmonic analysis to function spaces, differential equations, and data science, covering topics such a...

  7. Analysis of large fault trees based on functional decomposition

    International Nuclear Information System (INIS)

    Contini, Sergio; Matuzas, Vaidas

    2011-01-01

    With the advent of the Binary Decision Diagrams (BDD) approach in fault tree analysis, a significant enhancement has been achieved with respect to previous approaches, both in terms of efficiency and accuracy of the overall outcome of the analysis. However, the exponential increase of the number of nodes with the complexity of the fault tree may prevent the construction of the BDD. In these cases, the only way to complete the analysis is to reduce the complexity of the BDD by applying the truncation technique, which nevertheless implies the problem of estimating the truncation error or upper and lower bounds of the top-event unavailability. This paper describes a new method to analyze large coherent fault trees which can be advantageously applied when the working memory is not sufficient to construct the BDD. It is based on the decomposition of the fault tree into simpler disjoint fault trees containing a lower number of variables. The analysis of each simple fault tree is performed by using all the computational resources. The results from the analysis of all simpler fault trees are re-combined to obtain the results for the original fault tree. Two decomposition methods are herewith described: the first aims at determining the minimal cut sets (MCS) and the upper and lower bounds of the top-event unavailability; the second can be applied to determine the exact value of the top-event unavailability. Potentialities, limitations and possible variations of these methods will be discussed with reference to the results of their application to some complex fault trees.

  8. Analysis of large fault trees based on functional decomposition

    Energy Technology Data Exchange (ETDEWEB)

    Contini, Sergio, E-mail: sergio.contini@jrc.i [European Commission, Joint Research Centre, Institute for the Protection and Security of the Citizen, 21020 Ispra (Italy); Matuzas, Vaidas [European Commission, Joint Research Centre, Institute for the Protection and Security of the Citizen, 21020 Ispra (Italy)

    2011-03-15

    With the advent of the Binary Decision Diagrams (BDD) approach in fault tree analysis, a significant enhancement has been achieved with respect to previous approaches, both in terms of efficiency and accuracy of the overall outcome of the analysis. However, the exponential increase of the number of nodes with the complexity of the fault tree may prevent the construction of the BDD. In these cases, the only way to complete the analysis is to reduce the complexity of the BDD by applying the truncation technique, which nevertheless implies the problem of estimating the truncation error or upper and lower bounds of the top-event unavailability. This paper describes a new method to analyze large coherent fault trees which can be advantageously applied when the working memory is not sufficient to construct the BDD. It is based on the decomposition of the fault tree into simpler disjoint fault trees containing a lower number of variables. The analysis of each simple fault tree is performed by using all the computational resources. The results from the analysis of all simpler fault trees are re-combined to obtain the results for the original fault tree. Two decomposition methods are herewith described: the first aims at determining the minimal cut sets (MCS) and the upper and lower bounds of the top-event unavailability; the second can be applied to determine the exact value of the top-event unavailability. Potentialities, limitations and possible variations of these methods will be discussed with reference to the results of their application to some complex fault trees.

  9. A NEW TOOL FOR IMAGE ANALYSIS BASED ON CHEBYSHEV RATIONAL FUNCTIONS: CHEF FUNCTIONS

    International Nuclear Information System (INIS)

    Jiménez-Teja, Y.; Benítez, N.

    2012-01-01

    We introduce a new approach to the modeling of the light distribution of galaxies, an orthonormal polar basis formed by a combination of Chebyshev rational functions and Fourier polynomials that we call CHEF functions, or CHEFs. We have developed an orthonormalization process to apply this basis to pixelized images, and implemented the method as a Python pipeline. The new basis displays remarkable flexibility, being able to accurately fit all kinds of galaxy shapes, including irregulars, spirals, ellipticals, highly compact, and highly elongated galaxies. It does this while using fewer components than similar methods, as shapelets, and without producing artifacts, due to the efficiency of the rational Chebyshev polynomials to fit quickly decaying functions like galaxy profiles. The method is linear and very stable, and therefore is capable of processing large numbers of galaxies in a fast and automated way. Due to the high quality of the fits in the central parts of the galaxies, and the efficiency of the CHEF basis modeling galaxy profiles up to very large distances, the method provides highly accurate estimates of total galaxy fluxes and ellipticities. Future papers will explore in more detail the application of the method to perform multiband photometry, morphological classification, and weak shear measurements.

  10. A Goal-Function Approach to Analysis of Control Situations

    DEFF Research Database (Denmark)

    Lind, Morten

    2010-01-01

    The concept of situations plays a central role in all theories of meaning and context. and serve to frame or group events and other occurrences into coherent meaningful wholes. Situations are typed, may be interconnected and organized into higher level structures. In operation of industrial...... processes situations should identify operational aspects relevant for control agent’s decision making in plant supervision and control. Control situations can be understood as recurrent and interconnected patterns of control with important implications for control and HMI design. Goal-Function approaches...

  11. QTL Analysis and Functional Genomics of Animal Model

    DEFF Research Database (Denmark)

    Farajzadeh, Leila

    , for example, has enabled scientists to examine more complex interactions in connection with studies of properties and diseases. In her PhD project, Leila Farajzadeh integrated different organisational levels in biology, including genotype, phenotype, association studies, transcription profiles and genetic......In recent years, the use of functional genomics and next-generation sequencing technologies has increased the probability of success in studies of complex properties. The integration of large data sets from association studies, DNA resequencing, gene expression profiles and phenotypic data...

  12. Dispersion analysis for difference schemes: tables of generalized Airy functions

    International Nuclear Information System (INIS)

    Chin, R.C.Y.; Hedstrom, G.W.

    1978-01-01

    This papers contains graphs and tables of the function /sup Ai/p,q(/sup alpha,x/) =∫/sup infinity/: infinity (2π) -1 exp]y/sup p//p-αy/sup q//q+ixy]dy and its indefinite integral for p=3,5,7, for q=2,4,6, and for several values of α with α> or =0. It is shown how these tables should influence the choice of an artifical viscosity for a difference scheme for a linear hyperbolic equation

  13. Chronic job burnout and daily functioning: A theoretical analysis

    Directory of Open Access Journals (Sweden)

    Arnold B. Bakker

    2014-12-01

    Full Text Available In this article, we discuss the individual employee's role in the development of his/her job burnout. We review the antecedents and consequences of burnout, and propose a model with chronic burnout as a moderator of daily functioning in the workplace. Specifically, we argue that chronic burnout strengthens the loss cycle of daily job demands, daily exhaustion, and daily self-undermining. Additionally, we argue that chronic burnout weakens the gain cycle of daily job resources, daily work engagement, and daily job crafting. We conclude that employees with high levels of burnout need help in structurally changing their working conditions and health status.

  14. Morphology and function in the empirical analysis of reading adjustment

    Directory of Open Access Journals (Sweden)

    Carpio, Claudio

    2010-06-01

    Full Text Available The present study evaluated the effects of varying the criterion and the morphology of the percentage of correct response upon reading adjustment tasks. Participants were 20 voluntary students, distributed in four groups, which were differentiated by the certainty - variability of the criterion and the certainty - variability of the morphology of response to satisfy the criterion. All participants were exposed to a first evaluation, training and finally a second evaluation similar to the first one was applied. Results question the role of morphology as a comprehension strategy independent of a functional criterion, domain and of the text itself

  15. Functional analysis of Ficolin-3 mediated complement activation

    DEFF Research Database (Denmark)

    Hein, Estrid; Honoré, Christian Le Fèvre; Skjoedt, Mikkel-Ole

    2010-01-01

    assessed by C4, C3 and terminal complement complex (TCC) deposition. Serum Ficolin-3 bound to acBSA in a calcium dependent manner, while only minimal binding of Ficolin-2 and no binding of Ficolin-1 were observed. No binding to normal BSA was seen for any of the Ficolins. Serum C4, C3 and TCC deposition...... was applied to the samples that inhibited interference from the classical pathway due to the presence of anti-BSA antibodies in some sera. We describe a novel functional method for measuring complement activation mediated by Ficolin-3 in human serum up to the formation of TCC. The assay provides...

  16. Numerical analysis of data in dynamic function studies

    International Nuclear Information System (INIS)

    Riihimaeki, E.

    1975-01-01

    Relations between tracer theories, models for organ function and the numerical solution of parameters from tracer experiments are reviewed. A unified presentation is given in terms of systems theory. Dynamic tracer studies should give the flow and volume of the tracer and, possibly, indications of the internal structure of the organ studied. Proper program writing will facilitate the exchange of the programs between the users and thereby avoid duplication of effort. An important attribute in this respect is machine independence of the programs which is achieved by the use of a high-level language. (author)

  17. Advanced Connectivity Analysis (ACA): a Large Scale Functional Connectivity Data Mining Environment.

    Science.gov (United States)

    Chen, Rong; Nixon, Erika; Herskovits, Edward

    2016-04-01

    Using resting-state functional magnetic resonance imaging (rs-fMRI) to study functional connectivity is of great importance to understand normal development and function as well as a host of neurological and psychiatric disorders. Seed-based analysis is one of the most widely used rs-fMRI analysis methods. Here we describe a freely available large scale functional connectivity data mining software package called Advanced Connectivity Analysis (ACA). ACA enables large-scale seed-based analysis and brain-behavior analysis. It can seamlessly examine a large number of seed regions with minimal user input. ACA has a brain-behavior analysis component to delineate associations among imaging biomarkers and one or more behavioral variables. We demonstrate applications of ACA to rs-fMRI data sets from a study of autism.

  18. Income and children's behavioral functioning: a sequential mediation analysis.

    Science.gov (United States)

    Shelleby, Elizabeth C; Votruba-Drzal, Elizabeth; Shaw, Daniel S; Dishion, Thomas J; Wilson, Melvin N; Gardner, Frances

    2014-12-01

    Children from low-income households tend to exhibit higher levels of conduct problems and emotional problems, yet the pathways linking economic disadvantage to children's behavioral functioning are not well understood. This study uses data from the Early Steps Multisite (ESM) project (N = 731) to investigate associations between family income in early childhood and children's conduct problems and emotional problems in middle childhood. The study explores whether the associations from income to child conduct problems and emotional problems operate through maternal depressive symptoms and 3 family risk factors in early childhood-harsh parenting, parenting hassles, and chaos in the home environment. Results of a sequential mediation model revealed significant indirect effects of family income on children's conduct problems operating through maternal depressive symptoms and parenting hassles and indirect effects of family income on children's emotional problems operating through maternal depressive symptoms, chaos in the home environment, and parenting hassles. Implications of these findings for understanding processes through which income influences child functioning are discussed.

  19. Supervised learning with restricted training sets: a generating functional analysis

    Energy Technology Data Exchange (ETDEWEB)

    Heimel, J.A.F.; Coolen, A.C.C. [Department of Mathematics, King' s College London, Strand, London (United Kingdom)

    2001-10-26

    We study the dynamics of supervised on-line learning of realizable tasks in feed-forward neural networks. We focus on the regime where the number of examples used for training is proportional to the number of input channels N. Using generating functional techniques from spin glass theory, we are able to average over the composition of the training set and transform the problem for N{yields}{infinity} to an effective single pattern system described completely by the student autocovariance, the student-teacher overlap and the student response function with exact closed equations. Our method applies to arbitrary learning rules, i.e., not necessarily of a gradient-descent type. The resulting exact macroscopic dynamical equations can be integrated without finite-size effects up to any degree of accuracy, but their main value is in providing an exact and simple starting point for analytical approximation schemes. Finally, we show how, in the region of absent anomalous response and using the hypothesis that (as in detailed balance systems) the short-time part of the various operators can be transformed away, one can describe the stationary state of the network successfully by a set of coupled equations involving only four scalar order parameters. (author)

  20. Functional size analysis of bioactive materials by radiation inactivation

    International Nuclear Information System (INIS)

    Kume, Tamikazu

    1994-01-01

    When the research on various proteins including enzymes is carried out, first molecular weight is measured. The physical chemical methods used for measuring molecular weight cannot measure it in the state of actually acting in living bodies. Radiation inactivation method is the unique method which can measure the molecular weight of the active substances in living bodies. Paying attention to this point, recently it is attempted to measure the activity unit of enzymes, receptors and others, and to apply to the elucidation of their functions. In this report, the concept of the method of measuring molecular size based on radiation inactivation, the detailed experimental method and the points to which attention must be paid are described. Also its application to the elucidation of living body functions according to the example of the studies by the author is reported. The concept of the measurement of molecular weight by radiation inactivation is based on target theory. The preparation of samples, the effect of oxygen, radiation sources, dosimetry, irradiation temperature, internal standard process and so on are reported. The trend of the research is shown. (K.I.)

  1. Functional Parallel Factor Analysis for Functions of One- and Two-dimensional Arguments

    NARCIS (Netherlands)

    Choi, Ji Yeh; Hwang, Heungsun; Timmerman, Marieke

    Parallel factor analysis (PARAFAC) is a useful multivariate method for decomposing three-way data that consist of three different types of entities simultaneously. This method estimates trilinear components, each of which is a low-dimensional representation of a set of entities, often called a mode,

  2. Robustness of Multiple Objective Decision Analysis Preference Functions

    Science.gov (United States)

    2002-06-01

    Bayesian Decision Theory and Utilitarian Ethics ,” American Economic Review Papers and Proceedings, 68: 223-228 (May 1978). Hartsough, Bruce R. “A...1983). Morrell, Darryl and Eric Driver. “ Bayesian Network Implementation of Levi’s Epistemic Utility Decision Theory ,” International Journal Of...elicitation efficiency for the decision maker. Subject Terms Decision Analysis, Utility Theory , Elicitation Error, Operations Research, Decision

  3. Molecular cloning and functional analysis of the gene encoding ...

    African Journals Online (AJOL)

    Here we report for the first time the cloning of a full-length cDNA encoding GGPPS (Jc-GGPPS) from Jatropha curcas L. The full-length cDNA was 1414 base pair (bp), with an 1110-bp open reading frame (ORF) encoding a 370- amino-acids polypeptide. Bioinformatic analysis revealed that Jc-GGPPS is a member of the ...

  4. Analysis of cardiac diastolic function: application in coronary artery disease

    International Nuclear Information System (INIS)

    Miller, T.R.; Goldman, K.J.; Sampathkumaran, K.S.; Biello, D.R.; Ludbrook, P.A.; Sobel, B.E.

    1983-01-01

    Separation of systolic and diastolic parameters in gated cardiac blood-pool imaging (RVG) was achieved with the retention of two harmonics in the Fourier-series representation of the time-activity curve. Regional and global analysis of left-ventricular peak filling rate (PFR) and time to peak filling (TPF) was performed in 18 control subjects, 20 patients with coronary artery disease (CAD) but with normal RVG (normal regional wall motion and ejection fraction, and 16 CAD patients with abnormal RVG. In regional analysis of CAD patients, the standard deviation of the TPF histogram identified 13/20 (65%) of normal RVG patients and 12/16 (75%) of abnormal RVG patients as abnormal. In global analysis of CAD patients, PFR values identified 10/20 (50%) of normal RVG patients and 11/16 (69%) of abnormal RVG patients as abnormal. Thus, left-ventricular systolic and diastolic parameters can be separately measured with retention of higher-order harmonics in the Fourier transform, and regional inhomogeneity of diastolic filling can be detected in CAD patients with normal resting ejection fraction and wall motion

  5. Quality parameters analysis of optical imaging systems with enhanced focal depth using the Wigner distribution function

    Science.gov (United States)

    Zalvidea; Colautti; Sicre

    2000-05-01

    An analysis of the Strehl ratio and the optical transfer function as imaging quality parameters of optical elements with enhanced focal length is carried out by employing the Wigner distribution function. To this end, we use four different pupil functions: a full circular aperture, a hyper-Gaussian aperture, a quartic phase plate, and a logarithmic phase mask. A comparison is performed between the quality parameters and test images formed by these pupil functions at different defocus distances.

  6. Using functional analysis in archival appraisal a practical and effective alternative to traditional appraisal methodologies

    CERN Document Server

    Robyns, Marcus C

    2014-01-01

    In an age of scarcity and the challenge of electronic records, can archivists and records managers continue to rely upon traditional methodology essentially unchanged since the early 1950s? Using Functional Analysis in Archival Appraisal: A Practical and Effective Alternative to Traditional Appraisal Methodologies shows how archivists in other countries are already using functional analysis, which offers a better, more effective, and imminently more practical alternative to traditional appraisal methodologies that rely upon an analysis of the records themselves.

  7. A Statistical Framework for the Functional Analysis of Metagenomes

    Energy Technology Data Exchange (ETDEWEB)

    Sharon, Itai; Pati, Amrita; Markowitz, Victor; Pinter, Ron Y.

    2008-10-01

    Metagenomic studies consider the genetic makeup of microbial communities as a whole, rather than their individual member organisms. The functional and metabolic potential of microbial communities can be analyzed by comparing the relative abundance of gene families in their collective genomic sequences (metagenome) under different conditions. Such comparisons require accurate estimation of gene family frequencies. They present a statistical framework for assessing these frequencies based on the Lander-Waterman theory developed originally for Whole Genome Shotgun (WGS) sequencing projects. They also provide a novel method for assessing the reliability of the estimations which can be used for removing seemingly unreliable measurements. They tested their method on a wide range of datasets, including simulated genomes and real WGS data from sequencing projects of whole genomes. Results suggest that their framework corrects inherent biases in accepted methods and provides a good approximation to the true statistics of gene families in WGS projects.

  8. Engineering and Functional Analysis of Mitotic Kinases Through Chemical Genetics.

    Science.gov (United States)

    Jones, Mathew J K; Jallepalli, Prasad V

    2016-01-01

    During mitosis, multiple protein kinases transform the cytoskeleton and chromosomes into new and highly dynamic structures that mediate the faithful transmission of genetic information and cell division. However, the large number and strong conservation of mammalian kinases in general pose significant obstacles to interrogating them with small molecules, due to the difficulty in identifying and validating those which are truly selective. To overcome this problem, a steric complementation strategy has been developed, in which a bulky "gatekeeper" residue within the active site of the kinase of interest is replaced with a smaller amino acid, such as glycine or alanine. The enlarged catalytic pocket can then be targeted in an allele-specific manner with bulky purine analogs. This strategy provides a general framework for dissecting kinase function with high selectivity, rapid kinetics, and reversibility. In this chapter we discuss the principles and techniques needed to implement this chemical genetic approach in mammalian cells.

  9. Approximate models for the analysis of laser velocimetry correlation functions

    International Nuclear Information System (INIS)

    Robinson, D.P.

    1981-01-01

    Velocity distributions in the subchannels of an eleven pin test section representing a slice through a Fast Reactor sub-assembly were measured with a dual beam laser velocimeter system using a Malvern K 7023 digital photon correlator for signal processing. Two techniques were used for data reduction of the correlation function to obtain velocity and turbulence values. Whilst both techniques were in excellent agreement on the velocity, marked discrepancies were apparent in the turbulence levels. As a consequence of this the turbulence data were not reported. Subsequent investigation has shown that the approximate technique used as the basis of Malvern's Data Processor 7023V is restricted in its range of application. In this note alternative approximate models are described and evaluated. The objective of this investigation was to develop an approximate model which could be used for on-line determination of the turbulence level. (author)

  10. Extensions of positive definite functions applications and their harmonic analysis

    CERN Document Server

    Jorgensen, Palle E T; Tian, Feng

    2016-01-01

    This monograph deals with the mathematics of extending given partial data-sets obtained from experiments; Experimentalists frequently gather spectral data when the observed data is limited, e.g., by the precision of instruments; or by other limiting external factors. Here the limited information is a restriction, and the extensions take the form of full positive definite function on some prescribed group. It is therefore both an art and a science to produce solid conclusions from restricted or limited data. While the theory of is important in many areas of pure and applied mathematics, it is difficult for students and for the novice to the field, to find accessible presentations which cover all relevant points of view, as well as stressing common ideas and interconnections. We have aimed at filling this gap, and we have stressed hands-on-examples.

  11. ANALYSIS OF THE DEMOGRAPHIC POTENTIAL IN FUNCTION OF TOURISM

    Directory of Open Access Journals (Sweden)

    Mijalce Gjorgievski

    2011-06-01

    Full Text Available Man is the prime mover of the overall social economic and political life of the entire globe and therefore he is studied from various aspects depending on the needs of what we want to obtain information on the demographic potential and its features.In this paper, the subject of study will be processing potential through its demographic characteristics (number condition, age structure, natural increase, economic activity, religious composition, etc. for the tourism economy. We know that the basic elements of tourism are the natural and cultural wealth that detect, evaluate and put into operation in tourism. However, it has its function, the basic factor are the people who need to visit those places, so it is very important to understand the demographic characteristics of people in every region of the globe in order to come to some understanding of the habits, needs and affinities of people depending on age, nationality and religious affiliation, etc. when choosing their travel destination.

  12. Efficiency analysis of Chinese industry: A directional distance function approach

    International Nuclear Information System (INIS)

    Watanabe, Michio; Tanaka, Katsuya

    2007-01-01

    Two efficiency measures of Chinese industry were estimated at the provincial level from 1994 to 2002, using a directional output distance function. One is a traditional efficiency measure that considers only desirable output, while the other considers both desirable and undesirable outputs simultaneously. A comparison of the two measures revealed that efficiency levels are biased only if desirable output is considered. Five coastal provinces/municipalities that have attracted a large amount of foreign direct investment are found to be the most efficient when only desirable output is considered, and also when both desirable and undesirable outputs are considered. However, omitting undesirable output tends to lead to an overestimate of industrial efficiency levels in Shandong, Sichuan, and Hebei provinces. We also found that a province's industrial structure has significant effects on its efficiency levels

  13. A delivery transfer function (DTF) analysis for helical tomotherapy

    International Nuclear Information System (INIS)

    Kissick, Michael W; Mackie, Thomas Rockwell; Jeraj, Robert

    2007-01-01

    The previous theoretical work of a delivery transfer function (DTF) in radiotherapy is expanded to include the unique intensity modulation method of helical tomotherapy. In addition to the collimation of each beamlet, and the Gaussian scatter convolution spreading of the dose that other radiotherapy units have, helical tomotherapy uses 51 small arcs of varying lengths to adjust the intensity. The blurring from these arcs is not taken into account during treatment planning. A theoretical DTF is constructed, and a calculation is performed which includes this unique source motion in relation to the other DTF components. Various typical delivery parameters are used to generate resolution maps for a constant intensity projection. Near the isocenter, the transverse (to a given beam direction) blurring is small but at larger radii (>6 cm), the source blurring dominates over leaf size. For most clinical situations, this inherent source motion blurring is expected to be negligible

  14. Diagnostic radiology for functional analysis of the cervical vertebral column

    International Nuclear Information System (INIS)

    Kamieth, H.

    1986-01-01

    The book is averaged in 17 chapters. The first three, introductory chapters dealing with the significance of radiology for the functional diagnosis of the cervical spine are followed by three chapters discussing the movements of the atlantoaxial joints, the statics of the cervical spine, and the sagittal flexural movements in the C2-C7 segments. Subsequent chapters discuss the radiodiagnostical method according to Arlen, the innervation of the cervical spine segments of movement, disturbances of movement including restriction of movement, degenerative processes of the invertebral disks, and hypermobile disturbance of movement. The final chapters deal with compensational and dissociation phenomena, subluxations, defective or compulsive positions, etc., the causes of each, and with the clinical relevance of spondylochondrosis and arthrosis, and with the pain. With 171 figs [de

  15. Direct analysis of thymic function in children with Down's syndrome

    Directory of Open Access Journals (Sweden)

    Meschiari Liviana

    2005-02-01

    Full Text Available Abstract Background Down's syndrome (DS is characterized by several immunological defects, especially regarding T cell compartment. DS is considered the best example of accelerated ageing in humans. Direct observations of the thymus have shown that in DS this organ undergoes severe histological and morphological changes. However, no data on its capacity to generate T cells are present in the literature. Here, using a new technology based upon real time PCR, we have investigated the capacity of the thymus to produce and release newly generated T lymphocytes (the so called "recent thymic emigrants", RTE in children with DS. Methods We studied 8 children affected by DS, aged 2–7 years, compared with 8 age- and sex-matched healthy controls. Flow cytometry was used to determine different lymphocytes subsets. Real time PCR with the Taqman system was used to quantify the amount of RTE, i.e. peripheral blood lymphocytes that express the T cell receptor rearrangement excision circles (TREC. Results In comparison with control children, those with DS had a significant lower number of TREC+ peripheral blood cells. Moreover, in DS children but not in controls, a strong negative correlation between age and the levels of TREC+ cells was found. Conclusions The direct measure of thymic output indicates that the impairment of the organ results in a reduced production of newly generated T cells. This observation could suggest that cytokines able to modulate thymic function, such as interleukins, could be useful to improve the functionality of the organ and to treat the immunodeficiency present in DS subjects.

  16. Mutual Connectivity Analysis (MCA) Using Generalized Radial Basis Function Neural Networks for Nonlinear Functional Connectivity Network Recovery in Resting-State Functional MRI.

    Science.gov (United States)

    DSouza, Adora M; Abidin, Anas Zainul; Nagarajan, Mahesh B; Wismüller, Axel

    2016-03-29

    We investigate the applicability of a computational framework, called mutual connectivity analysis (MCA), for directed functional connectivity analysis in both synthetic and resting-state functional MRI data. This framework comprises of first evaluating non-linear cross-predictability between every pair of time series prior to recovering the underlying network structure using community detection algorithms. We obtain the non-linear cross-prediction score between time series using Generalized Radial Basis Functions (GRBF) neural networks. These cross-prediction scores characterize the underlying functionally connected networks within the resting brain, which can be extracted using non-metric clustering approaches, such as the Louvain method. We first test our approach on synthetic models with known directional influence and network structure. Our method is able to capture the directional relationships between time series (with an area under the ROC curve = 0.92 ± 0.037) as well as the underlying network structure (Rand index = 0.87 ± 0.063) with high accuracy. Furthermore, we test this method for network recovery on resting-state fMRI data, where results are compared to the motor cortex network recovered from a motor stimulation sequence, resulting in a strong agreement between the two (Dice coefficient = 0.45). We conclude that our MCA approach is effective in analyzing non-linear directed functional connectivity and in revealing underlying functional network structure in complex systems.

  17. Automated analysis of plethysmograms for functional studies of hemodynamics

    Science.gov (United States)

    Zatrudina, R. Sh.; Isupov, I. B.; Gribkov, V. Yu.

    2018-04-01

    The most promising method for the quantitative determination of cardiovascular tone indicators and of cerebral hemodynamics indicators is the method of impedance plethysmography. The accurate determination of these indicators requires the correct identification of the characteristic points in the thoracic impedance plethysmogram and the cranial impedance plethysmogram respectively. An algorithm for automatic analysis of these plethysmogram is presented. The algorithm is based on the hard temporal relationships between the phases of the cardiac cycle and the characteristic points of the plethysmogram. The proposed algorithm does not require estimation of initial data and selection of processing parameters. Use of the method on healthy subjects showed a very low detection error of characteristic points.

  18. Visual analysis of music in function of music video

    Directory of Open Access Journals (Sweden)

    Antal Silard

    2015-01-01

    Full Text Available Wide-spread all over the planet, incorporating all music genres, the music video, the subject matter of this analysis, has become irreplaceable in promotions, song presentations, an artist's image, visual aesthetics of subculture; today, most of the countries in the world have a channel devoted to music only, i.e. to music video. The form started to develop rapidly in the 50s of the twentieth century, alongside television. As it developed, its purpose has changed: from a simple presentation of musicians to an independent video form.

  19. Local electric dipole moments for periodic systems via density functional theory embedding.

    Science.gov (United States)

    Luber, Sandra

    2014-12-21

    We describe a novel approach for the calculation of local electric dipole moments for periodic systems. Since the position operator is ill-defined in periodic systems, maximally localized Wannier functions based on the Berry-phase approach are usually employed for the evaluation of local contributions to the total electric dipole moment of the system. We propose an alternative approach: within a subsystem-density functional theory based embedding scheme, subset electric dipole moments are derived without any additional localization procedure, both for hybrid and non-hybrid exchange-correlation functionals. This opens the way to a computationally efficient evaluation of local electric dipole moments in (molecular) periodic systems as well as their rigorous splitting into atomic electric dipole moments. As examples, Infrared spectra of liquid ethylene carbonate and dimethyl carbonate are presented, which are commonly employed as solvents in Lithium ion batteries.

  20. Local electric dipole moments for periodic systems via density functional theory embedding

    Energy Technology Data Exchange (ETDEWEB)

    Luber, Sandra, E-mail: sandra.luber@chem.uzh.ch [Institut für Chemie, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich (Switzerland)

    2014-12-21

    We describe a novel approach for the calculation of local electric dipole moments for periodic systems. Since the position operator is ill-defined in periodic systems, maximally localized Wannier functions based on the Berry-phase approach are usually employed for the evaluation of local contributions to the total electric dipole moment of the system. We propose an alternative approach: within a subsystem-density functional theory based embedding scheme, subset electric dipole moments are derived without any additional localization procedure, both for hybrid and non-hybrid exchange–correlation functionals. This opens the way to a computationally efficient evaluation of local electric dipole moments in (molecular) periodic systems as well as their rigorous splitting into atomic electric dipole moments. As examples, Infrared spectra of liquid ethylene carbonate and dimethyl carbonate are presented, which are commonly employed as solvents in Lithium ion batteries.

  1. Functional Connectivity Parcellation of the Human Thalamus by Independent Component Analysis.

    Science.gov (United States)

    Zhang, Sheng; Li, Chiang-Shan R

    2017-11-01

    As a key structure to relay and integrate information, the thalamus supports multiple cognitive and affective functions through the connectivity between its subnuclei and cortical and subcortical regions. Although extant studies have largely described thalamic regional functions in anatomical terms, evidence accumulates to suggest a more complex picture of subareal activities and connectivities of the thalamus. In this study, we aimed to parcellate the thalamus and examine whole-brain connectivity of its functional clusters. With resting state functional magnetic resonance imaging data from 96 adults, we used independent component analysis (ICA) to parcellate the thalamus into 10 components. On the basis of the independence assumption, ICA helps to identify how subclusters overlap spatially. Whole brain functional connectivity of each subdivision was computed for independent component's time course (ICtc), which is a unique time series to represent an IC. For comparison, we computed seed-region-based functional connectivity using the averaged time course across all voxels within a thalamic subdivision. The results showed that, at p analysis, ICtc analysis revealed patterns of connectivity that were more distinguished between thalamic clusters. ICtc analysis demonstrated thalamic connectivity to the primary motor cortex, which has eluded the analysis as well as previous studies based on averaged time series, and clarified thalamic connectivity to the hippocampus, caudate nucleus, and precuneus. The new findings elucidate functional organization of the thalamus and suggest that ICA clustering in combination with ICtc rather than seed-region analysis better distinguishes whole-brain connectivities among functional clusters of a brain region.

  2. Fault tree and failure mode and effects analysis of a digital safety function

    International Nuclear Information System (INIS)

    Maskuniitty, M.; Pulkkinen, U.

    1995-01-01

    The principles of fault tree and failure mode and effects analysis (FMEA) for the analysis of digital safety functions of nuclear power plants are discussed. Based on experiences from a case study, a proposal for a full scale analysis is presented. The feasibility and applicability the above mentioned reliability engineering methods are discussed. (author). 13 refs, 1 fig., 2 tabs

  3. Thermodynamic analysis of solar assisted multi-functional trigeneration system

    Directory of Open Access Journals (Sweden)

    Önder KIZILKAN

    2016-02-01

    Full Text Available In this study, modelling and thermodynamic analysis of solar assisted trigeneration system was carried out. The required thermal energy for gas and vapor cycles were supplied from solar tower which is a new concept for gas cycle applications. Additionally, an absorption refrigeration cycle, vapor production process, drying process and water heating process were integrated to the system. Energy and exergy efficiencies of the trigeneration system were determined by the application of first and second law analyses. The results showed that the gas cycle efficiency was found to be 31%, vapor cycle efficiency was found to be 28% and coefficient of performance (COP values of the refrigeration system was found to be 0.77. Also the highest exergy destruction rate was found to be 4154 kW in solar tower.Keywords: Solar tower, Trigeneration, Gas cycle, Vapor cycle, Energy, Exergy

  4. Computational analysis and functional expression of ancestral copepod luciferase.

    Science.gov (United States)

    Takenaka, Yasuhiro; Noda-Ogura, Akiko; Imanishi, Tadashi; Yamaguchi, Atsushi; Gojobori, Takashi; Shigeri, Yasushi

    2013-10-10

    We recently reported the cDNA sequences of 11 copepod luciferases from the superfamily Augaptiloidea in the order Calanoida. They were classified into two groups, Metridinidae and Heterorhabdidae/Lucicutiidae families, by phylogenetic analyses. To elucidate the evolutionary processes, we have now further isolated 12 copepod luciferases from Augaptiloidea species (Metridia asymmetrica, Metridia curticauda, Pleuromamma scutullata, Pleuromamma xiphias, Lucicutia ovaliformis and Heterorhabdus tanneri). Codon-based synonymous/nonsynonymous tests of positive selection for 25 identified copepod luciferases suggested that positive Darwinian selection operated in the evolution of Heterorhabdidae luciferases, whereas two types of Metridinidae luciferases had diversified via neutral mechanism. By in silico analysis of the decoded amino acid sequences of 25 copepod luciferases, we inferred two protein sequences as ancestral copepod luciferases. They were expressed in HEK293 cells where they exhibited notable luciferase activity both in intracellular lysates and cultured media, indicating that the luciferase activity was established before evolutionary diversification of these copepod species. © 2013.

  5. Numerical analysis on pool boiling using user defined function

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Sung Uk; Jeon, Byong Guk; Kim, Seok; Euh, Dong-Jin [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    PAFS (passive auxiliary feedwater system) adopted in the APR+ (Advanced Power Reactor Plus) of Korea is one such application. When PAFS is activated with an actuation signal, steam from the steam generator passes through heat exchanger tubes submerged in a water tank of the PAFS. Outside these heat exchanger tubes, nucleate boiling phenomena appears. In the present work, a numerical study is reported on three-dimensional transient state pool boiling of water having an immersed heat source. The velocity vector fields during the decrease in the water level are numerically investigated in a pool, and the accuracy of the results is checked by comparing the experimental results conducted using the PIV techniques by Kim et al. These numerical results can be used as basic research data for an analysis and prediction of the natural circulation phenomena in the cooling tank of the passive safety system in a nuclear power plant.

  6. Analysis on Influential Functions in the Weighted Software Network

    Directory of Open Access Journals (Sweden)

    Haitao He

    2018-01-01

    Full Text Available Identifying influential nodes is important for software in terms of understanding the design patterns and controlling the development and the maintenance process. However, there are no efficient methods to discover them so far. Based on the invoking dependency relationships between the nodes, this paper proposes a novel approach to define the node importance for mining the influential software nodes. First, according to the multiple execution information, we construct a weighted software network (WSN to denote the software execution dependency structure. Second, considering the invoking times and outdegree about software nodes, we improve the method PageRank and put forward the targeted algorithm FunctionRank to evaluate the node importance (NI in weighted software network. It has higher influence when the node has lager value of NI. Finally, comparing the NI of nodes, we can obtain the most influential nodes in the software network. In addition, the experimental results show that the proposed approach has good performance in identifying the influential nodes.

  7. Soil-structure interaction analysis by Green function

    International Nuclear Information System (INIS)

    Muto, Kiyoshi; Kobayashi, Toshio; Nakahara, Mitsuharu.

    1985-01-01

    Using the method of discretized Green function which had been suggested by the authors, the parametric study of the effects of base mat foundation thickness and soil stiffness were conducted. There was no upper structure effects from the response and reaction stress of the soil by employing different base mat foundation thicknesses. However, the response stress of base mat itself had considerable effect on the base mat foundation stress. The harder the soil, became larger accelerations, and smaller displacements on the upper structure. The upper structure lines of force were directed onto the soil. In the case of soft soil, the reaction soil stress were distributed evenly over the entire reactor building area. Common characteristics of all cases, in-plane shear deformation of the upper floor occured and in-plane acceleration and displacement at the center of the structure become larger. Also, the soil stresses around the shield wall of the base mat foundation became large cecause of the effect of the shield wall bending. (Kubozono, M.)

  8. Functional analysis of the MAPK pathways in fungi.

    Science.gov (United States)

    Martínez-Soto, Domingo; Ruiz-Herrera, José

    The Mitogen-Activated Protein Kinase (MAPK) signaling pathways constitute one of the most important and evolutionarily conserved mechanisms for the perception of extracellular information in all the eukaryotic organisms. The MAPK pathways are involved in the transfer to the cell of the information perceived from extracellular stimuli, with the final outcome of activation of different transcription factors that regulate gene expression in response to them. In all species of fungi, the MAPK pathways have important roles in their physiology and development; e.g. cell cycle control, mating, morphogenesis, response to different stresses, resistance to UV radiation and to temperature changes, cell wall assembly and integrity, degradation of cellular organelles, virulence, cell-cell signaling, fungus-plant interaction, and response to damage-associated molecular patterns (DAMPs). Considering the importance of the phylogenetically conserved MAPK pathways in fungi, an updated review of the knowledge on them is discussed in this article. This information reveals their importance, their distribution in fungal species evolutionarily distant and with different lifestyles, their organization and function, and the interactions occurring between different MAPK pathways, and with other signaling pathways, for the regulation of the most complex cellular processes. Copyright © 2017 Asociación Española de Micología. Publicado por Elsevier España, S.L.U. All rights reserved.

  9. Functional Analysis of Glycosylation of Zika Virus Envelope Protein

    Directory of Open Access Journals (Sweden)

    Camila R. Fontes-Garfias

    2017-10-01

    Full Text Available Summary: Zika virus (ZIKV infection causes devastating congenital abnormities and Guillain-Barré syndrome. The ZIKV envelope (E protein is responsible for viral entry and represents a major determinant for viral pathogenesis. Like other flaviviruses, the ZIKV E protein is glycosylated at amino acid N154. To study the function of E glycosylation, we generated a recombinant N154Q ZIKV that lacks the E glycosylation and analyzed the mutant virus in mammalian and mosquito hosts. In mouse models, the mutant was attenuated, as evidenced by lower viremia, decreased weight loss, and no mortality; however, knockout of E glycosylation did not significantly affect neurovirulence. Mice immunized with the mutant virus developed a robust neutralizing antibody response and were completely protected from wild-type ZIKV challenge. In mosquitoes, the mutant virus exhibited diminished oral infectivity for the Aedes aegypti vector. Collectively, the results demonstrate that E glycosylation is critical for ZIKV infection of mammalian and mosquito hosts. : Zika virus (ZIKV causes devastating congenital abnormities and Guillain-Barré syndrome. Fontes-Garfias et al. showed that the glycosylation of ZIKV envelope protein plays an important role in infecting mosquito vectors and pathogenesis in mouse. Keywords: Zika virus, glycosylation, flavivirus entry, mosquito transmission, vaccine

  10. Functional Analysis of Glycosylation of Zika Virus Envelope Protein.

    Science.gov (United States)

    Fontes-Garfias, Camila R; Shan, Chao; Luo, Huanle; Muruato, Antonio E; Medeiros, Daniele B A; Mays, Elizabeth; Xie, Xuping; Zou, Jing; Roundy, Christopher M; Wakamiya, Maki; Rossi, Shannan L; Wang, Tian; Weaver, Scott C; Shi, Pei-Yong

    2017-10-31

    Zika virus (ZIKV) infection causes devastating congenital abnormities and Guillain-Barré syndrome. The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant for viral pathogenesis. Like other flaviviruses, the ZIKV E protein is glycosylated at amino acid N154. To study the function of E glycosylation, we generated a recombinant N154Q ZIKV that lacks the E glycosylation and analyzed the mutant virus in mammalian and mosquito hosts. In mouse models, the mutant was attenuated, as evidenced by lower viremia, decreased weight loss, and no mortality; however, knockout of E glycosylation did not significantly affect neurovirulence. Mice immunized with the mutant virus developed a robust neutralizing antibody response and were completely protected from wild-type ZIKV challenge. In mosquitoes, the mutant virus exhibited diminished oral infectivity for the Aedes aegypti vector. Collectively, the results demonstrate that E glycosylation is critical for ZIKV infection of mammalian and mosquito hosts. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  11. Itopride therapy for functional dyspepsia: a meta-analysis.

    Science.gov (United States)

    Huang, Xuan; Lv, Bin; Zhang, Shuo; Fan, Yi-Hong; Meng, Li-Na

    2012-12-28

    To evaluate the therapeutic effects of itopride vs other drugs (placebo, domperidone, mosapride) for functional dyspepsia (FD). Randomized controlled trials (RCTs) of itopride for FD were retrieved from databases. Relevant information was extracted and analyzed, using the relative risk (RR) and weighted mean deviation, as appropriate. A random or fixed effect model was used, based on the heterogeneity of the included articles, and visual inspection of funnel plots was used to evaluate publication bias. Nine RCTs enrolling 2620 FD cases were included; 1372 cases received itopride treatment and 1248 cases received placebo or other drugs (control groups). Compared with control groups, itopride had superior RR values of 1.11 [95%CI: (1.03, 1.19), P = 0.006], 1.21 [95%CI: (1.03, 1.44), P = 0.02], and 1.24 [95%CI: (1.01, 1.53), P = 0.04] for global patient assessment, postprandial fullness, and early satiety, respectively. For the Leeds Dyspepsia Questionnaire score, the weighted mean deviation was -1.38 [95%CI: (-1.75, -1.01), P itopride and control groups. The funnel plots for all indicators showed no evidence of publication bias. Itopride has good efficacy in terms of global patients assessment, postprandial fullness, and early satiety in the treatment of patients with FD and shows a low rate of adverse reactions. Itopride can greatly improve FD syndromes-score.

  12. Functional analysis of guinea pig β1-adrenoceptor.

    Science.gov (United States)

    Tanaka, Yoshio; Takahashi, Hiromi; Shibata, Sayuri; Namiki, Kana; Kimura, Sadao; Koike, Katsuo; Kasuya, Yoshitoshi

    2011-12-01

    Although similarity of pharmacological responses to certain stimuli between guinea pigs and humans has been reported, this has been poorly defined by a molecular biological approach. In this study, we cloned the gene of guinea pig ?1-adrenoceptor (ADRB1). The deduced amino acid sequence of guinea pig ADRB1 (467-aa) showed 91% and 92% identity with the human and rat ADRB1 sequences, respectively. Using HEK293T cells expressing guinea pig, human and rat ADRB1s independently, we elucidated the functional characteristics of each ADRB1. The ligand-binding profiles and the concentration-response relationships for isoprenaline-induced cyclic adenosine monophosphate (cAMP) production were similar among the three ADRB1s. Isoprenaline also induced phosphorylation of extracellular-signal related kinases (ERK) through ADRB1s in a concentration-dependent manner. The minimum effective concentration of isoprenaline for phosphorylation of ERK, through guinea pig ADRB1 was the same as through human ADRB1, but markedly lower than that of through rat ADRB1. ERK phosphorylation through guinea pig ADRB1 was sensitive to pertussis toxin, a dominant-negative ras and PD98059, indicating that a G(i)-mediated pathway is involved in the ADRB1/ERK signaling loop. These results suggest that the G(i)-coupling efficacy of guinea pig and human ADRB1s may be higher than that of rat ADRB1.

  13. Expression profiling of human renal carcinomas with functional taxonomic analysis

    Science.gov (United States)

    2002-01-01

    Background Molecular characterization has contributed to the understanding of the inception, progression, treatment and prognosis of cancer. Nucleic acid array-based technologies extend molecular characterization of tumors to thousands of gene products. To effectively discriminate between tumor sub-types, reliable laboratory techniques and analytic methods are required. Results We derived mRNA expression profiles from 21 human tissue samples (eight normal kidneys and 13 kidney tumors) and two pooled samples using the Affymetrix GeneChip platform. A panel of ten clustering algorithms combined with four data pre-processing methods identified a consensus cluster dendrogram in 18 of 40 analyses and of these 16 used a logarithmic transformation. Within the consensus dendrogram the expression profiles of the samples grouped according to tissue type; clear cell and chromophobe carcinomas displayed distinctly different gene expression patterns. By using a rigorous statistical selection based method we identified 355 genes that showed significant (p Matrix Organization and Adhesion. Conclusions Affymetrix GeneChip profiling differentiated clear cell and chromophobe carcinomas from one another and from normal kidney cortex. Clustering methods that used logarithmic transformation of data sets produced dendrograms consistent with the sample biology. Functional taxonomy provided a practical approach to the interpretation of gene expression data. PMID:12356337

  14. Expression profiling of human renal carcinomas with functional taxonomic analysis

    Directory of Open Access Journals (Sweden)

    Madore Steven J

    2002-09-01

    Full Text Available Abstract Background Molecular characterization has contributed to the understanding of the inception, progression, treatment and prognosis of cancer. Nucleic acid array-based technologies extend molecular characterization of tumors to thousands of gene products. To effectively discriminate between tumor sub-types, reliable laboratory techniques and analytic methods are required. Results We derived mRNA expression profiles from 21 human tissue samples (eight normal kidneys and 13 kidney tumors and two pooled samples using the Affymetrix GeneChip platform. A panel of ten clustering algorithms combined with four data pre-processing methods identified a consensus cluster dendrogram in 18 of 40 analyses and of these 16 used a logarithmic transformation. Within the consensus dendrogram the expression profiles of the samples grouped according to tissue type; clear cell and chromophobe carcinomas displayed distinctly different gene expression patterns. By using a rigorous statistical selection based method we identified 355 genes that showed significant (p Conclusions Affymetrix GeneChip profiling differentiated clear cell and chromophobe carcinomas from one another and from normal kidney cortex. Clustering methods that used logarithmic transformation of data sets produced dendrograms consistent with the sample biology. Functional taxonomy provided a practical approach to the interpretation of gene expression data.

  15. A structure-function analysis in patients with prekallikrein deficiency.

    Science.gov (United States)

    Girolami, Antonio; Ferrari, Silvia; Cosi, Elisabetta; Lombardi, Anna Maria

    2017-11-22

    To investigate the structure-function relation in prekallikrein (PK) deficiency. PK is one of the proteins of the contact phase of blood coagulation which at the present time is the object of a revival of interest. All patients with PK deficiency who had been investigated by molecular biology techniques are the object of the present investigation. Details of patients were obtained from personal files and a time-unlimited PubMed search. Only cases with a molecular-biology-based diagnosis were included. Twelve families were included. The total number of missense mutation was 10, together with 3 stop codons and 2 insertions. These mutations involved mainly exons 11 and 14. There were eight proved homozygotes and three compound heterozygotes. In one instance, homozygosity was probable but not proved. In nine cases, the defect was Type I, whereas it was Type II in the remaining three. No bleeding manifestations were present in 11 of the 12 probands. One proband had epistaxis, but she had hypertension. Altogether, four patients had hypertension and one of them had also two myocardial infarctions. Despite the paucity of cases, it was established that the majority of mutations involved the catalytic domain. It is auspicable that future reports of patients with this disorder should include molecular studies. This would certainly contribute to the understanding of the contact phase of blood coagulation.

  16. Analysis of Functional Data with Focus on Multinomial Regression and Multilevel Data

    DEFF Research Database (Denmark)

    Mousavi, Seyed Nourollah

    Functional data analysis (FDA) is a fast growing area in statistical research with increasingly diverse range of application from economics, medicine, agriculture, chemometrics, etc. Functional regression is an area of FDA which has received the most attention both in aspects of application...... and methodological development. Our main Functional data analysis (FDA) is a fast growing area in statistical research with increasingly diverse range of application from economics, medicine, agriculture, chemometrics, etc. Functional regression is an area of FDA which has received the most attention both in aspects...

  17. Application of functional analysis methods to assess human-dog interactions.

    Science.gov (United States)

    Feuerbacher, Erica N; Wynne, Clive D L

    2016-12-01

    Research on owner-dog relationships suggests that they have remarkable features, paralleling those of infant to parents. In this study, we investigated whether, after being separated, access to the owner would function as a reinforcer for domestic dog behavior. We then conducted a functional analysis to determine the specific functional reinforcer (e.g., owner access, attention). Our results demonstrate that owner access can function as a reinforcer. This has implications for understanding the owner-dog relationship and using owner access as a training tool. © 2016 Society for the Experimental Analysis of Behavior.

  18. Control-flow analysis of function calls and returns by abstract interpretation

    DEFF Research Database (Denmark)

    Midtgaard, Jan; Jensen, Thomas P.

    2009-01-01

    We derive a control-flow analysis that approximates the interprocedural control-flow of both function calls and returns in the presence of first-class functions and tail-call optimization. In addition to an abstract environment, our analysis computes for each expression an abstract control stack......, effectively approximating where function calls return across optimized tail calls. The analysis is systematically calculated by abstract interpretation of the stack-based CaEK abstract machine of Flanagan et al. using a series of Galois connections. Abstract interpretation provides a unifying setting in which...

  19. Theoretical foundations of functional data analysis, with an introduction to linear operators

    CERN Document Server

    Hsing, Tailen

    2015-01-01

    Theoretical Foundations of Functional Data Analysis, with an Introduction to Linear Operators provides a uniquely broad compendium of the key mathematical concepts and results that are relevant for the theoretical development of functional data analysis (FDA).The self-contained treatment of selected topics of functional analysis and operator theory includes reproducing kernel Hilbert spaces, singular value decomposition of compact operators on Hilbert spaces and perturbation theory for both self-adjoint and non self-adjoint operators. The probabilistic foundation for FDA is described from the

  20. Empirical Green's function analysis: Taking the next step

    Science.gov (United States)

    Hough, S.E.

    1997-01-01

    An extension of the empirical Green's function (EGF) method is presented that involves determination of source parameters using standard EGF deconvolution, followed by inversion for a common attenuation parameter for a set of colocated events. Recordings of three or more colocated events can thus be used to constrain a single path attenuation estimate. I apply this method to recordings from the 1995-1996 Ridgecrest, California, earthquake sequence; I analyze four clusters consisting of 13 total events with magnitudes between 2.6 and 4.9. I first obtain corner frequencies, which are used to infer Brune stress drop estimates. I obtain stress drop values of 0.3-53 MPa (with all but one between 0.3 and 11 MPa), with no resolved increase of stress drop with moment. With the corner frequencies constrained, the inferred attenuation parameters are very consistent; they imply an average shear wave quality factor of approximately 20-25 for alluvial sediments within the Indian Wells Valley. Although the resultant spectral fitting (using corner frequency and ??) is good, the residuals are consistent among the clusters analyzed. Their spectral shape is similar to the the theoretical one-dimensional response of a layered low-velocity structure in the valley (an absolute site response cannot be determined by this method, because of an ambiguity between absolute response and source spectral amplitudes). I show that even this subtle site response can significantly bias estimates of corner frequency and ??, if it is ignored in an inversion for only source and path effects. The multiple-EGF method presented in this paper is analogous to a joint inversion for source, path, and site effects; the use of colocated sets of earthquakes appears to offer significant advantages in improving resolution of all three estimates, especially if data are from a single site or sites with similar site response.