WorldWideScience

Sample records for vp3-containing ribonucleoprotein core

  1. Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core

    Energy Technology Data Exchange (ETDEWEB)

    Montemayor, Eric J.; Didychuk, Allison L.; Liao, Honghong; Hu, Panzhou; Brow, David A.; Butcher, Samuel E. (UW)

    2017-01-01

    U6 small nuclear RNA (snRNA) is a key component of the active site of the spliceosome, a large ribonucleoprotein complex that catalyzes the splicing of precursor messenger RNA. Prior to its incorporation into the spliceosome, U6 is bound by the protein Prp24, which facilitates unwinding of the U6 internal stem-loop (ISL) so that it can pair with U4 snRNA. A previously reported crystal structure of the `core' of the U6 small nuclear ribonucleoprotein (snRNP) contained an ISL-stabilized A62G mutant of U6 bound to all four RNA-recognition motif (RRM) domains of Prp24 [Montemayoret al.(2014),Nature Struct. Mol. Biol.21, 544–551]. The structure revealed a novel topology containing interlocked rings of protein and RNA that was not predicted by prior biochemical and genetic data. Here, the crystal structure of the U6 snRNP core with a wild-type ISL is reported. This complex crystallized in a new space group, apparently owing in part to the presence of an intramolecular cross-link in RRM1 that was not observed in the previously reported U6-A62G structure. The structure exhibits the same protein–RNA interface and maintains the unique interlocked topology. However, the orientation of the wild-type ISL is altered relative to the A62G mutant structure, suggesting inherent structural dynamics that may facilitate its pairing with U4. Consistent with their similar architectures in the crystalline state, the wild-type and A62G variants of U6 exhibit similar Prp24-binding affinities and electrophoretic mobilities when analyzed by gel-shift assay.

  2. The ribonucleoprotein Csr network.

    Science.gov (United States)

    Seyll, Ethel; Van Melderen, Laurence

    2013-11-08

    Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr) network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators. CsrA binds to mRNA targets and regulates translation either negatively or positively. Binding to small non-coding RNAs controls activity of this protein. Expression of these regulators is tightly regulated at the level of transcription and stability by various global regulators (RNAses, two-component systems, alarmone). We discuss the implications of these complex regulations in bacterial adaptation.

  3. Substrate recognition by ribonucleoprotein ribonuclease MRP.

    Science.gov (United States)

    Esakova, Olga; Perederina, Anna; Quan, Chao; Berezin, Igor; Krasilnikov, Andrey S

    2011-02-01

    The ribonucleoprotein complex ribonuclease (RNase) MRP is a site-specific endoribonuclease essential for the survival of the eukaryotic cell. RNase MRP closely resembles RNase P (a universal endoribonuclease responsible for the maturation of the 5' ends of tRNA) but recognizes distinct substrates including pre-rRNA and mRNA. Here we report the results of an in vitro selection of Saccharomyces cerevisiae RNase MRP substrates starting from a pool of random sequences. The results indicate that RNase MRP cleaves single-stranded RNA and is sensitive to sequences in the immediate vicinity of the cleavage site requiring a cytosine at the position +4 relative to the cleavage site. Structural implications of the differences in substrate recognition by RNases P and MRP are discussed.

  4. Characterization of LINE-1 ribonucleoprotein particles.

    Directory of Open Access Journals (Sweden)

    Aurélien J Doucet

    2010-10-01

    Full Text Available The average human genome contains a small cohort of active L1 retrotransposons that encode two proteins (ORF1p and ORF2p required for their mobility (i.e., retrotransposition. Prior studies demonstrated that human ORF1p, L1 RNA, and an ORF2p-encoded reverse transcriptase activity are present in ribonucleoprotein (RNP complexes. However, the inability to physically detect ORF2p from engineered human L1 constructs has remained a technical challenge in the field. Here, we have employed an epitope/RNA tagging strategy with engineered human L1 retrotransposons to identify ORF1p, ORF2p, and L1 RNA in a RNP complex. We next used this system to assess how mutations in ORF1p and/or ORF2p impact RNP formation. Importantly, we demonstrate that mutations in the coiled-coil domain and RNA recognition motif of ORF1p, as well as the cysteine-rich domain of ORF2p, reduce the levels of ORF1p and/or ORF2p in L1 RNPs. Finally, we used this tagging strategy to localize the L1-encoded proteins and L1 RNA to cytoplasmic foci that often were associated with stress granules. Thus, we conclude that a precise interplay among ORF1p, ORF2p, and L1 RNA is critical for L1 RNP assembly, function, and L1 retrotransposition.

  5. Vaults: a ribonucleoprotein particle involved in drug resistance?

    NARCIS (Netherlands)

    Mossink, MH; Zon, van A; Scheper, R.J.; Sonneveld, P.; Wiemer, EA

    2003-01-01

    Vaults are ribonucleoprotein particles found in the cytoplasm of eucaryotic cells. The 13 MDa particles are composed of multiple copies of three proteins: an M(r) 100 000 major vault protein (MVP) and two minor vault proteins of M(r) 193 000 (vault poly-(ADP-ribose) polymerase) and M(r) 240 000

  6. Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.

    Directory of Open Access Journals (Sweden)

    Rachel W Anantha

    Full Text Available BACKGROUND: Heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C is a core component of 40S ribonucleoprotein particles that bind pre-mRNAs and influence their processing, stability and export. Breast cancer tumor suppressors BRCA1, BRCA2 and PALB2 form a complex and play key roles in homologous recombination (HR, DNA double strand break (DSB repair and cell cycle regulation following DNA damage. METHODS: PALB2 nucleoprotein complexes were isolated using tandem affinity purification from nuclease-solubilized nuclear fraction. Immunofluorescence was used for localization studies of proteins. siRNA-mediated gene silencing and flow cytometry were used for studying DNA repair efficiency and cell cycle distribution/checkpoints. The effect of hnRNP C on mRNA abundance was assayed using quantitative reverse transcriptase PCR. RESULTS AND SIGNIFICANCE: We identified hnRNP C as a component of a nucleoprotein complex containing breast cancer suppressor proteins PALB2, BRCA2 and BRCA1. Notably, other components of the 40S ribonucleoprotein particle were not present in the complex. hnRNP C was found to undergo significant changes of sub-nuclear localization after ionizing radiation (IR and to partially localize to DNA damage sites. Depletion of hnRNP C substantially altered the normal balance of repair mechanisms following DSB induction, reducing HR usage in particular, and impaired S phase progression after IR. Moreover, loss of hnRNP C strongly reduced the abundance of key HR proteins BRCA1, BRCA2, RAD51 and BRIP1, which can be attributed, at least in part, to the downregulation of their mRNAs due to aberrant splicing. Our results establish hnRNP C as a key regulator of BRCA gene expression and HR-based DNA repair. They also suggest the existence of an RNA regulatory program at sites of DNA damage, which involves a unique function of hnRNP C that is independent of the 40S ribonucleoprotein particles and most other hnRNP proteins.

  7. CORE

    DEFF Research Database (Denmark)

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin

    2013-01-01

    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  8. The Thoc1 Ribonucleoprotein as a Novel Biomarker for Prostate Cancer Treatment Assignment

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-14-1-0475 TITLE: The Thoc1 Ribonucleoprotein as a Novel Biomarker for Prostate Cancer Treatment Assignment PRINCIPAL...provision of law , no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently...15Sept 2016 - 14Sep2017 4. TITLE AND SUBTITLE The Thoc1 Ribonucleoprotein as a Novel Biomarker for Prostate 5a. CONTRACT NUMBER Cancer Treatment

  9. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.

    NARCIS (Netherlands)

    Welting, T.J.M.; Venrooij, W.J.W. van; Pruijn, G.J.M.

    2004-01-01

    The eukaryotic ribonuclease for mitochondrial RNA processing (RNase MRP) is mainly located in the nucleoli and belongs to the small nucleolar ribonucleoprotein (snoRNP) particles. RNase MRP is involved in the processing of pre-rRNA and the generation of RNA primers for mitochondrial DNA replication.

  10. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18

    OpenAIRE

    Yang, Ruiqing; Weber, David J.; Carrier, France

    2006-01-01

    Thioredoxin (TRX) is a key protein of the cellular redox metabolism, which expression is increased in several tumors especially gastric tumors. Even though ultraviolet (UV) and hypoxia specifically induce TRX, the mechanisms that lead to increased TRX levels are still ill defined. Here, we show that the heterogenous ribonucleoprotein A18 (hnRNP A18) RNA Binding Domain (RBD) and the arginine, glycine (RGG) rich domain can bind TRX 3′-untranslated region (3′-UTR) independently but both domains ...

  11. The Thoc1 Ribonucleoprotein as a Novel Biomarker for ProstateCancer Treatment Assignment

    Science.gov (United States)

    2016-10-01

    tissue microarray, immunostaining, ribonucleoprotein 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF...groups: Cancer and Leukemia Group B (CALGB). List of specific aims: 1. Assess the effect of a telephone-based dietary intervention on PSA, PSA...derived T cells and myeloid cells and host-type hematopoietic and non-hematopoietic cells. Prior pending, now active funding Title: Novel Mouse

  12. Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing.

    Science.gov (United States)

    Mout, Rubul; Ray, Moumita; Yesilbag Tonga, Gulen; Lee, Yi-Wei; Tay, Tristan; Sasaki, Kanae; Rotello, Vincent M

    2017-03-28

    Genome editing through the delivery of CRISPR/Cas9-ribonucleoprotein (Cas9-RNP) reduces unwanted gene targeting and avoids integrational mutagenesis that can occur through gene delivery strategies. Direct and efficient delivery of Cas9-RNP into the cytosol followed by translocation to the nucleus remains a challenge. Here, we report a remarkably highly efficient (∼90%) direct cytoplasmic/nuclear delivery of Cas9 protein complexed with a guide RNA (sgRNA) through the coengineering of Cas9 protein and carrier nanoparticles. This construct provides effective (∼30%) gene editing efficiency and opens up opportunities in studying genome dynamics.

  13. Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control.

    Science.gov (United States)

    Hogg, J Robert; Collins, Kathleen

    2007-12-01

    Humans express four distinct non-protein-coding Y RNAs (ncRNAs). To investigate Y RNA functional diversification, we exploited an RNA-based affinity purification method to isolate ribonucleoproteins (RNPs) assembled on individual human Y RNAs. Silver staining and mass spectrometry revealed that the Ro and La proteins assemble with all Y RNAs, while additional proteins associate with specific Y RNAs. Unexpectedly, Y5 RNA uniquely copurified ribosomal protein L5 and its binding partner 5S RNA. These findings reveal a contribution of Y5 to 5S surveillance and suggest that interactions between Ro-Y5 and L5-5S RNPs establish 5S RNA as a target of quality control.

  14. Data on structural transitions in domains of hordeivirus TGB1 protein forming ribonucleoprotein complex

    Directory of Open Access Journals (Sweden)

    Valentin V. Makarov

    2016-09-01

    Full Text Available This data article is related to the research article entitled “in vitro properties of hordeivirus TGB1 protein forming ribonucleoprotein complexes” (Makarov et al., 2015 [1], demonstrating that upon incubation with viral RNA the poa semilatent hordeivirus (PSLV TGB1 protein (the movement 63 K protein encoded by the first gene of the triple gene block in vitro forms RNP structures resembling filamentous virus-like particles and its internal domain (ID performs a major structural role in this process. This article reports the additional results on the structural lability of ID and the structural transitions in the C-terminal NTPase/helicase domain (HELD induced by interaction with tRNA and phosphorylation.

  15. Genome editing in maize directed by CRISPR-Cas9 ribonucleoprotein complexes.

    Science.gov (United States)

    Svitashev, Sergei; Schwartz, Christine; Lenderts, Brian; Young, Joshua K; Mark Cigan, A

    2016-11-16

    Targeted DNA double-strand breaks have been shown to significantly increase the frequency and precision of genome editing. In the past two decades, several double-strand break technologies have been developed. CRISPR-Cas9 has quickly become the technology of choice for genome editing due to its simplicity, efficiency and versatility. Currently, genome editing in plants primarily relies on delivering double-strand break reagents in the form of DNA vectors. Here we report biolistic delivery of pre-assembled Cas9-gRNA ribonucleoproteins into maize embryo cells and regeneration of plants with both mutated and edited alleles. Using this method of delivery, we also demonstrate DNA- and selectable marker-free gene mutagenesis in maize and recovery of plants with mutated alleles at high frequencies. These results open new opportunities to accelerate breeding practices in a wide variety of crop species.

  16. Genome editing in maize directed by CRISPR–Cas9 ribonucleoprotein complexes

    Science.gov (United States)

    Svitashev, Sergei; Schwartz, Christine; Lenderts, Brian; Young, Joshua K.; Mark Cigan, A.

    2016-01-01

    Targeted DNA double-strand breaks have been shown to significantly increase the frequency and precision of genome editing. In the past two decades, several double-strand break technologies have been developed. CRISPR–Cas9 has quickly become the technology of choice for genome editing due to its simplicity, efficiency and versatility. Currently, genome editing in plants primarily relies on delivering double-strand break reagents in the form of DNA vectors. Here we report biolistic delivery of pre-assembled Cas9–gRNA ribonucleoproteins into maize embryo cells and regeneration of plants with both mutated and edited alleles. Using this method of delivery, we also demonstrate DNA- and selectable marker-free gene mutagenesis in maize and recovery of plants with mutated alleles at high frequencies. These results open new opportunities to accelerate breeding practices in a wide variety of crop species. PMID:27848933

  17. Conserved regions of ribonucleoprotein ribonuclease MRP are involved in interactions with its substrate.

    Science.gov (United States)

    Esakova, Olga; Perederina, Anna; Berezin, Igor; Krasilnikov, Andrey S

    2013-08-01

    Ribonuclease (RNase) MRP is a ubiquitous and essential site-specific eukaryotic endoribonuclease involved in the metabolism of a wide range of RNA molecules. RNase MRP is a ribonucleoprotein with a large catalytic RNA moiety that is closely related to the RNA component of RNase P, and multiple proteins, most of which are shared with RNase P. Here, we report the results of an ultraviolet-cross-linking analysis of interactions between a photoreactive RNase MRP substrate and the Saccharomyces cerevisiae RNase MRP holoenzyme. The results show that the substrate interacts with phylogenetically conserved RNA elements universally found in all enzymes of the RNase P/MRP family, as well as with a phylogenetically conserved RNA region that is unique to RNase MRP, and demonstrate that four RNase MRP protein components, all shared with RNase P, interact with the substrate. Implications for the structural organization of RNase MRP and the roles of its components are discussed.

  18. Nuclear import of influenza A viral ribonucleoprotein complexes is mediated by two nuclear localization sequences on viral nucleoprotein

    Directory of Open Access Journals (Sweden)

    Panté Nelly

    2007-06-01

    Full Text Available Abstract Background The influenza A virus replicates in the nucleus of its host cell. Thus, entry of the influenza genome into the cell nucleus is necessary for establishing infection. The genome of the influenza A virus consists of eight single-stranded, negative-sense RNA molecules, individually packed with several copies of the viral nucleoprotein (NP into ribonucleoprotein particles (vRNPs. These vRNPs are large, rod-shaped complexes containing a core of NP, around which the RNA is helically wrapped. The vRNPs are the entities that enter the nucleus, and their nuclear import must be mediated by nuclear localization sequences (NLSs exposed on the vRNPs. NP contains at least two putative NLSs, one at the N-terminus (NLS1 and one in the middle (NLS2 of the protein. These NP NLSs have been shown to mediate the nuclear import of recombinant NP molecules. However, it remains to be determined which NLS mediates the nuclear import of influenza vRNP complexes. Results To directly track the nuclear import of the influenza A genome, we developed an experimental assay based on digitonin-permeabilized cells and fluorescently-labeled vRNPs isolated from the influenza A virus. We used this assay to determine the contribution of the two proposed NLSs on NP to the nuclear import of influenza vRNP complexes. Peptides that mimic each of the two NLSs on NP were used to compete with vRNPs for their nuclear import receptors. In addition, antibodies against the two NP NLSs were used to block the NLSs on the vRNP complexes, and thereby inhibit vRNP nuclear import. Both peptide competition and antibody inhibition of either sequence resulted in decreased nuclear accumulation of vRNPs. The two sequences act independently of each other, as inhibition of only one of the two NLSs still resulted in significant, though diminished, nuclear import of vRNPs. Furthermore, when both sequences were blocked, vRNP nuclear import was almost completely inhibited. Antibody inhibition

  19. Torsin Mediates Primary Envelopment of Large Ribonucleoprotein Granules at the Nuclear Envelope

    Directory of Open Access Journals (Sweden)

    Vahbiz Jokhi

    2013-04-01

    Full Text Available A previously unrecognized mechanism through which large ribonucleoprotein (megaRNP granules exit the nucleus is by budding through the nuclear envelope (NE. This mechanism is akin to the nuclear egress of herpes-type viruses and is essential for proper synapse development. However, the molecular machinery required to remodel the NE during this process is unknown. Here, we identify Torsin, an AAA-ATPase that in humans is linked to dystonia, as a major mediator of primary megaRNP envelopment during NE budding. In torsin mutants, megaRNPs accumulate within the perinuclear space, and the messenger RNAs contained within fail to reach synaptic sites, preventing normal synaptic protein synthesis and thus proper synaptic bouton development. These studies begin to establish the cellular machinery underlying the exit of megaRNPs via budding, offer an explanation for the “nuclear blebbing” phenotype found in dystonia models, and provide an important link between Torsin and the synaptic phenotypes observed in dystonia.

  20. Expression and localization of heterogeneous nuclear ribonucleoprotein K in mouse ovaries and preimplantation embryos

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Ping [The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai (China); Wang, Ningling [Department of Assisted Reproduction, Shanghai Ninth People' s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai (China); Lin, Xianhua; Jin, Li [The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai (China); Xu, Hong, E-mail: xuhong1168@126.com [The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai (China); Li, Rong [The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai (China); Huang, Hefeng, E-mail: huanghefg@hotmail.com [The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai (China)

    2016-02-26

    Heterogeneous nuclear ribonucleoprotein K (hnRNP K), an evolutionarily conserved protein, is involved in several important cellular processes that are relevant to cell proliferation, differentiation, apoptosis, and cancer development. However, details of hnRNP K expression during mammalian oogenesis and preimplantation embryo development are lacking. The present study investigates the expression and cellular localization of K protein in the mouse ovaries and preimplantation embryos using immunostaining. We demonstrate, for the first time, that hnRNP K is abundantly expressed in the nuclei of mouse oocytes in primordial, primary and secondary follicles. In germ vesicle (GV)-stage oocytes, hnRNP K accumulates in the germinal vesicle in a spot distribution manner. After germinal vesicle breakdown, speckled hnRNP K is diffusely distributed in the cytoplasm. However, after fertilization, the K protein relocates into the female and male pronucleus and persists in the blastomere nuclei. Localization of K protein in the human ovary and ovarian granulosa cell tumor (GCT) was also investigated. Overall, this study provides important morphological evidence to better understand the possible roles of hnRNP K in mammalian oogenesis and early embryo development. - Highlights: • HnRNP K localizes in the nucleus of GV-stage oocyte in a punctate distribution. • HnRNP K strongly accumulates in zygotic pronuclei as condensed spots. • The localization of hnRNP K during oogenesis and embryogenesis is characteristic. • HnRNP K might have an important role in oogenesis and embryonic development.

  1. DNA-Free Genetically Edited Grapevine and Apple Protoplast Using CRISPR/Cas9 Ribonucleoproteins.

    Science.gov (United States)

    Malnoy, Mickael; Viola, Roberto; Jung, Min-Hee; Koo, Ok-Jae; Kim, Seokjoong; Kim, Jin-Soo; Velasco, Riccardo; Nagamangala Kanchiswamy, Chidananda

    2016-01-01

    The combined availability of whole genome sequences and genome editing tools is set to revolutionize the field of fruit biotechnology by enabling the introduction of targeted genetic changes with unprecedented control and accuracy, both to explore emergent phenotypes and to introduce new functionalities. Although plasmid-mediated delivery of genome editing components to plant cells is very efficient, it also presents some drawbacks, such as possible random integration of plasmid sequences in the host genome. Additionally, it may well be intercepted by current process-based GMO regulations, complicating the path to commercialization of improved varieties. Here, we explore direct delivery of purified CRISPR/Cas9 ribonucleoproteins (RNPs) to the protoplast of grape cultivar Chardonnay and apple cultivar such as Golden delicious fruit crop plants for efficient targeted mutagenesis. We targeted MLO-7, a susceptible gene in order to increase resistance to powdery mildew in grape cultivar and DIPM-1, DIPM-2, and DIPM-4 in the apple to increase resistance to fire blight disease. Furthermore, efficient protoplast transformation, the molar ratio of Cas9 and sgRNAs were optimized for each grape and apple cultivar. The targeted mutagenesis insertion and deletion rate was analyzed using targeted deep sequencing. Our results demonstrate that direct delivery of CRISPR/Cas9 RNPs to the protoplast system enables targeted gene editing and paves the way to the generation of DNA-free genome edited grapevine and apple plants.

  2. Targeted Gene Knockin in Porcine Somatic Cells Using CRISPR/Cas Ribonucleoproteins

    Directory of Open Access Journals (Sweden)

    Ki-Eun Park

    2016-05-01

    Full Text Available The pig is an ideal large animal model for genetic engineering applications. A relatively short gestation interval and large litter size makes the pig a conducive model for generating and propagating genetic modifications. The domestic pig also shares close similarity in anatomy, physiology, size, and life expectancy, making it an ideal animal for modeling human diseases. Often, however, the technical difficulties in generating desired genetic modifications such as targeted knockin of short stretches of sequences or transgenes have impeded progress in this field. In this study, we have investigated and compared the relative efficiency of CRISPR/Cas ribonucleoproteins in engineering targeted knockin of pseudo attP sites downstream of a ubiquitously expressed COL1A gene in porcine somatic cells and generated live fetuses by somatic cell nuclear transfer (SCNT. By leveraging these knockin pseudo attP sites, we have demonstrated subsequent phiC31 integrase mediated integration of green fluorescent protein (GFP transgene into the site. This work for the first time created an optimized protocol for CRISPR/Cas mediated knockin in porcine somatic cells, while simultaneously creating a stable platform for future transgene integration and generating transgenic animals.

  3. Unexpected heterogeneity derived from Cas9 ribonucleoprotein-introduced clonal cells at the HPRT1 locus.

    Science.gov (United States)

    Sakuma, Tetsushi; Mochida, Keiji; Nakade, Shota; Ezure, Toru; Minagawa, Sachi; Yamamoto, Takashi

    2018-02-09

    Single-cell cloning is an essential technique for establishing genome-edited cell clones mediated by programmable nucleases such as CRISPR-Cas9. However, residual genome-editing activity after single-cell cloning may cause heterogeneity in the clonal cells. Previous studies showed efficient mutagenesis and rapid degradation of CRISPR-Cas9 components in cultured cells by introducing Cas9 ribonucleoproteins (RNPs). In this study, we investigated how the timing for single-cell cloning of Cas9 RNP-transfected cells affected the heterogeneity of the resultant clones. We carried out transfection of Cas9 RNPs targeting several loci in the HPRT1 gene in HCT116 cells, followed by single-cell cloning at 24, 48, 72 hr and 1 week post-transfection. After approximately 3 weeks of incubation, the clonal cells were collected and genotyped by high-resolution microchip electrophoresis and Sanger sequencing. Unexpectedly, long-term incubation before single-cell cloning resulted in highly heterogeneous clones. We used a lipofection method for transfection, and the media containing transfectable RNPs were not removed before single-cell cloning. Therefore, the active Cas9 RNPs were considered to be continuously incorporated into cells during the precloning incubation. Our findings provide a warning that lipofection of Cas9 RNPs may cause continuous introduction of gene mutations depending on the experimental procedures. © 2018 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

  4. Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins.

    Science.gov (United States)

    Lai, Ming-Chih; Tarn, Woan-Yuh

    2004-07-23

    Serine/arginine-rich proteins (SR proteins) function in precursor mRNA (pre-mRNA) splicing and may also act as adaptors for mRNA export. SR proteins are dynamically phosphorylated in their RS domain, and differential phosphorylation modulates their splicing activity and subcellular localization. In this study, we investigated the influence of phosphorylation on the function of SR proteins in events occurring during mRNA maturation. Immunoprecipitation experiments showed that the mRNA export receptor TAP associates preferentially with the hypophosphorylated form of shuttling SR proteins, including ASF/SF2. Overexpression of ASF induced subnuclear relocalization of TAP to SR protein-enriched nuclear speckles, suggesting their interaction in vivo. Moreover, the ASF found in a nucleoplasmic fraction rich in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes is hyperphosphorylated, whereas mature messenger RNP (mRNP)-bound ASF is hypophosphorylated. Therefore, hypophosphorylation of ASF in mRNPs coincides with its higher affinity for TAP, suggesting that dephosphorylation of ASF promotes both its incorporation into mRNPs and recruitment of TAP for mRNA export. Thus, the phosphorylation state of RS domains may modulate the function of mammalian shuttling SR proteins during mRNA maturation or export.

  5. Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation

    Directory of Open Access Journals (Sweden)

    Qishan Chen

    2013-01-01

    Full Text Available Stem cells possess huge importance in developmental biology, disease modelling, cell replacement therapy, and tissue engineering in regenerative medicine because they have the remarkable potential for self-renewal and to differentiate into almost all the cell types in the human body. Elucidation of molecular mechanisms regulating stem cell potency and differentiation is essential and critical for extensive application. Heterogeneous nuclear ribonucleoproteins (hnRNPs are modular proteins consisting of RNA-binding motifs and auxiliary domains characterized by extensive and divergent functions in nucleic acid metabolism. Multiple roles of hnRNPs in transcriptional and posttranscriptional regulation enable them to be effective gene expression regulators. More recent findings show that hnRNP proteins are crucial factors implicated in maintenance of stem cell self-renewal and pluripotency and cell differentiation. The hnRNPs interact with certain sequences in target gene promoter regions to initiate transcription. In addition, they recognize 3′UTR or 5′UTR of specific gene mRNA forming mRNP complex to regulate mRNA stability and translation. Both of these regulatory pathways lead to modulation of gene expression that is associated with stem cell proliferation, cell cycle control, pluripotency, and committed differentiation.

  6. Investigating Engineered Ribonucleoprotein Particles to Improve Oral RNAi Delivery in Crop Insect Pests

    Directory of Open Access Journals (Sweden)

    François-Xavier Gillet

    2017-04-01

    Full Text Available Genetically modified (GM crops producing double-stranded RNAs (dsRNAs are being investigated largely as an RNA interference (RNAi-based resistance strategy against crop insect pests. However, limitations of this strategy include the sensitivity of dsRNA to insect gut nucleases and its poor insect cell membrane penetration. Working with the insect pest cotton boll weevil (Anthonomus grandis, we showed that the chimeric protein PTD-DRBD (peptide transduction domain—dsRNA binding domain combined with dsRNA forms a ribonucleoprotein particle (RNP that improves the effectiveness of the RNAi mechanism in the insect. The RNP slows down nuclease activity, probably by masking the dsRNA. Furthermore, PTD-mediated internalization in insect gut cells is achieved within minutes after plasma membrane contact, limiting the exposure time of the RNPs to gut nucleases. Therefore, the RNP provides an approximately 2-fold increase in the efficiency of insect gene silencing upon oral delivery when compared to naked dsRNA. Taken together, these data demonstrate the role of engineered RNPs in improving dsRNA stability and cellular entry, representing a path toward the design of enhanced RNAi strategies in GM plants against crop insect pests.

  7. Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization

    Science.gov (United States)

    Ariza, Antonio; Tanner, Sian J.; Walter, Cheryl T.; Dent, Kyle C.; Shepherd, Dale A.; Wu, Weining; Matthews, Susan V.; Hiscox, Julian A.; Green, Todd J.; Luo, Ming; Elliott, Richard M.; Fooks, Anthony R.; Ashcroft, Alison E.; Stonehouse, Nicola J.; Ranson, Neil A.; Barr, John N.; Edwards, Thomas A.

    2013-01-01

    All orthobunyaviruses possess three genome segments of single-stranded negative sense RNA that are encapsidated with the virus-encoded nucleocapsid (N) protein to form a ribonucleoprotein (RNP) complex, which is uncharacterized at high resolution. We report the crystal structure of both the Bunyamwera virus (BUNV) N–RNA complex and the unbound Schmallenberg virus (SBV) N protein, at resolutions of 3.20 and 2.75 Å, respectively. Both N proteins crystallized as ring-like tetramers and exhibit a high degree of structural similarity despite classification into different orthobunyavirus serogroups. The structures represent a new RNA-binding protein fold. BUNV N possesses a positively charged groove into which RNA is deeply sequestered, with the bases facing away from the solvent. This location is highly inaccessible, implying that RNA polymerization and other critical base pairing events in the virus life cycle require RNP disassembly. Mutational analysis of N protein supports a correlation between structure and function. Comparison between these crystal structures and electron microscopy images of both soluble tetramers and authentic RNPs suggests the N protein does not bind RNA as a repeating monomer; thus, it represents a newly described architecture for bunyavirus RNP assembly, with implications for many other segmented negative-strand RNA viruses. PMID:23595147

  8. Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization.

    Science.gov (United States)

    Ariza, Antonio; Tanner, Sian J; Walter, Cheryl T; Dent, Kyle C; Shepherd, Dale A; Wu, Weining; Matthews, Susan V; Hiscox, Julian A; Green, Todd J; Luo, Ming; Elliott, Richard M; Fooks, Anthony R; Ashcroft, Alison E; Stonehouse, Nicola J; Ranson, Neil A; Barr, John N; Edwards, Thomas A

    2013-06-01

    All orthobunyaviruses possess three genome segments of single-stranded negative sense RNA that are encapsidated with the virus-encoded nucleocapsid (N) protein to form a ribonucleoprotein (RNP) complex, which is uncharacterized at high resolution. We report the crystal structure of both the Bunyamwera virus (BUNV) N-RNA complex and the unbound Schmallenberg virus (SBV) N protein, at resolutions of 3.20 and 2.75 Å, respectively. Both N proteins crystallized as ring-like tetramers and exhibit a high degree of structural similarity despite classification into different orthobunyavirus serogroups. The structures represent a new RNA-binding protein fold. BUNV N possesses a positively charged groove into which RNA is deeply sequestered, with the bases facing away from the solvent. This location is highly inaccessible, implying that RNA polymerization and other critical base pairing events in the virus life cycle require RNP disassembly. Mutational analysis of N protein supports a correlation between structure and function. Comparison between these crystal structures and electron microscopy images of both soluble tetramers and authentic RNPs suggests the N protein does not bind RNA as a repeating monomer; thus, it represents a newly described architecture for bunyavirus RNP assembly, with implications for many other segmented negative-strand RNA viruses.

  9. Regulatory RNPs: a novel class of ribonucleoproteins that potentially contribute to ribosome heterogeneity

    Directory of Open Access Journals (Sweden)

    Aaron R. Poole

    2017-09-01

    Full Text Available Many ribonucleoproteins (RNPs, which are comprised of noncoding RNA and associated proteins, are involved in essential cellular processes such as translation and pre-mRNA splicing. One class of RNP is the small Cajal body-specific RNP (scaRNP, which contributes to the biogenesis of small nuclear RNPs (snRNPs that are central components of the spliceosome. Three scaRNAs are internally processed, generating stable nucleolus-enriched RNAs of unknown function. Here, we provide data that show that these RNAs become part of RNPs we term regulatory RNPs (regRNPs. Most modifications within rRNA (predominantly pseudouridylation and ribose 2′-O-methylation are conducted by small nucleolar RNPs (snoRNPs, and we provide evidence that the activity of at least some of these snoRNPs is under the control of regRNPs. Because modifications within rRNA can vary in different physiological or pathological situations, rRNA modifications are thought to be the major source of ribosome heterogeneity. Our identification of regRNPs thus provides a potential mechanism for how ribosome heterogeneity may be accomplished. This work also provides additional functional connections between the Cajal body and the nucleolus.

  10. Fragile X mental retardation protein stimulates ribonucleoprotein assembly of influenza A virus

    Science.gov (United States)

    Zhou, Zhuo; Cao, Mengmeng; Guo, Yang; Zhao, Lili; Wang, Jingfeng; Jia, Xue; Li, Jianguo; Wang, Conghui; Gabriel, Gülsah; Xue, Qinghua; Yi, Yonghong; Cui, Sheng; Jin, Qi; Wang, Jianwei; Deng, Tao

    2014-02-01

    The ribonucleoprotein (RNP) of the influenza A virus is responsible for the transcription and replication of viral RNA in the nucleus. These processes require interplay between host factors and RNP components. Here, we report that the Fragile X mental retardation protein (FMRP) targets influenza virus RNA synthesis machinery and facilitates virus replication both in cell culture and in mice. We demonstrate that FMRP transiently associates with viral RNP and stimulates viral RNP assembly through RNA-mediated interaction with the nucleoprotein. Furthermore, the KH2 domain of FMRP mediates its association with the nucleoprotein. A point mutation (I304N) in the KH2 domain, identified from a Fragile X syndrome patient, disrupts the FMRP-nucleoprotein association and abolishes the ability of FMRP to participate in viral RNP assembly. We conclude that FMRP is a critical host factor used by influenza viruses to facilitate viral RNP assembly. Our observation reveals a mechanism of influenza virus RNA synthesis and provides insights into FMRP functions.

  11. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18.

    Science.gov (United States)

    Yang, Ruiqing; Weber, David J; Carrier, France

    2006-01-01

    Thioredoxin (TRX) is a key protein of the cellular redox metabolism, which expression is increased in several tumors especially gastric tumors. Even though ultraviolet (UV) and hypoxia specifically induce TRX, the mechanisms that lead to increased TRX levels are still ill defined. Here, we show that the heterogenous ribonucleoprotein A18 (hnRNP A18) RNA Binding Domain (RBD) and the arginine, glycine (RGG) rich domain can bind TRX 3'-untranslated region (3'-UTR) independently but both domains are required for maximal binding. Immunoprecipitation (IP) of hnRNP A18-mRNAs complexes and co-localization of hnRNP A18 and TRX transcripts on ribosomal fractions confirm the interaction of hnRNP A18 with TRX transcripts in cells. Moreover, down regulation of hnRNP A18 correlates with a significant reduction of TRX protein levels. In addition, hnRNP A18 increases TRX translation and interacts with the eukaryotic Initiation Factor 4G (eIF4G), a component of the general translational machinery. Furthermore, hnRNP A18 phosphorylation by the hypoxia inducible GSK3beta increases hnRNP A18 RNA binding activity in vitro and in RKO cells in response to UV radiation. These data support a regulatory role for hnRNP A18 in TRX post-transcriptional expression possibly through a kissing loop model bridging TRX 3'- and 5'-UTRs through eIF4G.

  12. Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP.

    Science.gov (United States)

    Lemieux, Bruno; Laterreur, Nancy; Perederina, Anna; Noël, Jean-François; Dubois, Marie-Line; Krasilnikov, Andrey S; Wellinger, Raymund J

    2016-05-19

    Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic protein. Additional proteins are required for activity on telomeres in vivo. Here, we report that the Pop1, Pop6, and Pop7 proteins, known components of RNase P and RNase MRP, bind to yeast telomerase RNA and are essential constituents of the telomerase holoenzyme. Pop1/Pop6/Pop7 binding is specific and involves an RNA domain highly similar to a protein-binding domain in the RNAs of RNase P/MRP. The results also show that Pop1/Pop6/Pop7 function to maintain the essential components Est1 and Est2 on the RNA in vivo. Consistently, addition of Pop1 allows for telomerase activity reconstitution with wild-type telomerase RNA in vitro. Thus, the same chaperoning module has allowed the evolution of functionally and, remarkably, structurally distinct RNPs, telomerase, and RNases P/MRP from unrelated progenitor RNAs. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation.

    Science.gov (United States)

    Meyerson, Nicholas R; Zhou, Ligang; Guo, Yusong R; Zhao, Chen; Tao, Yizhi J; Krug, Robert M; Sawyer, Sara L

    2017-11-08

    TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the antiviral interferon response. The NS1 protein from all strains of influenza A virus binds TRIM25, although not all virus strains block the interferon response, suggesting alternative mechanisms for TRIM25 action. Here we present a nuclear role for TRIM25 in specifically restricting influenza A virus replication. TRIM25 inhibits viral RNA synthesis through a direct mechanism that is independent of its ubiquitin ligase activity and the interferon pathway. This activity can be inhibited by the viral NS1 protein. TRIM25 inhibition of viral RNA synthesis results from its binding to viral ribonucleoproteins (vRNPs), the structures containing individual viral RNA segments, the viral polymerase, and multiple viral nucleoproteins. TRIM25 binding does not inhibit initiation of capped-RNA-primed viral mRNA synthesis by the viral polymerase. Rather, the onset of RNA chain elongation is inhibited because TRIM25 prohibits the movement of RNA into the polymerase complex. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. RNA in development: how ribonucleoprotein granules regulate the life cycles of pathogenic protozoa.

    Science.gov (United States)

    Kramer, Susanne

    2014-01-01

    Ribonucleoprotein (RNP) granules are important posttranscriptional regulators of messenger RNA (mRNA) fate. Several types of RNP granules specifically regulate gene expression during development of multicellular organisms and are commonly referred to as germ granules. The function of germ granules is not entirely understood and probably diverse, but it is generally agreed that one main function is posttranscriptional regulation of gene expression during early development, when transcription is silent. One example is the translational repression of maternally derived mRNAs in oocytes. Here, I hope to show that the need for regulation of gene expression by RNP granules is not restricted to animal development, but plays an equally important role during the development of pathogenic protozoa. Apicomplexa and Trypanosomatidae have complex life cycles with frequent host changes. The need to quickly adapt gene expression to a new environment as well as the ability to suppress translation to survive latencies is critical for successful completion of life cycles. Posttranscriptional gene regulation is not necessarily simpler in protozoa. Apicomplexa surprise with the presence of micro RNA (miRNAs) and upstream open reading frames (µORFs). Trypanosomes have an unusually large repertoire of different RNP granule types. A better understanding of RNP granules in protozoa may help to gain insight into the evolutionary origin of RNP granules: Trypanosomes for example have two types of granules with interesting similarities to animal germ granules. © 2013 John Wiley & Sons, Ltd.

  15. Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif

    Energy Technology Data Exchange (ETDEWEB)

    Coburn, Katherine; Melville, Zephan; Aligholizadeh, Ehson; Roth, Braden M.; Varney, Kristen M.; Carrier, France; Pozharski, Edwin; Weber, David J.

    2017-03-22

    The heterogeneous ribonucleoprotein A18 (hnRNP A18) is upregulated in hypoxic regions of various solid tumors and promotes tumor growthviathe coordination of mRNA transcripts associated with pro-survival genes. Thus, hnRNP A18 represents an important therapeutic target in tumor cells. Presented here is the first X-ray crystal structure to be reported for the RNA-recognition motif of hnRNP A18. By comparing this structure with those of homologous RNA-binding proteins (i.e.hnRNP A1), three residues on one face of an antiparallel β-sheet (Arg48, Phe50 and Phe52) and one residue in an unstructured loop (Arg41) were identified as likely to be involved in protein–nucleic acid interactions. This structure helps to serve as a foundation for biophysical studies of this RNA-binding protein and structure-based drug-design efforts for targeting hnRNP A18 in cancer, such as malignant melanoma, where hnRNP A18 levels are elevated and contribute to disease progression.

  16. Highly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes.

    Science.gov (United States)

    Chen, Sean; Lee, Benjamin; Lee, Angus Yiu-Fai; Modzelewski, Andrew J; He, Lin

    2016-07-08

    The CRISPR/Cas9 system has been employed to efficiently edit the genomes of diverse model organisms. CRISPR-mediated mouse genome editing is typically accomplished by microinjection of Cas9 DNA/RNA and single guide RNA (sgRNA) into zygotes to generate modified animals in one step. However, microinjection is a technically demanding, labor-intensive, and costly procedure with poor embryo viability. Here, we describe a simple and economic electroporation-based strategy to deliver Cas9/sgRNA ribonucleoproteins into mouse zygotes with 100% efficiency for in vivo genome editing. Our methodology, designated as CRISPR RNP Electroporation of Zygotes (CRISPR-EZ), enables highly efficient and high-throughput genome editing in vivo, with a significant improvement in embryo viability compared with microinjection. Using CRISPR-EZ, we generated a variety of editing schemes in mouse embryos, including indel (insertion/deletion) mutations, point mutations, large deletions, and small insertions. In a proof-of-principle experiment, we used CRISPR-EZ to target the tyrosinase (Tyr) gene, achieving 88% bi-allelic editing and 42% homology-directed repair-mediated precise sequence modification in live mice. Taken together, CRISPR-EZ is simple, economic, high throughput, and highly efficient with the potential to replace microinjection for in vivo genome editing in mice and possibly in other mammals. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  17. Heterogeneous nuclear ribonucleoprotein K inhibits heat shock-induced transcriptional activity of heat shock factor 1.

    Science.gov (United States)

    Kim, Hee-Jung; Lee, Jae-Jin; Cho, Jin-Hwan; Jeong, Jaeho; Park, A Young; Kang, Wonmo; Lee, Kong-Joo

    2017-08-04

    When cells are exposed to heat shock and various other stresses, heat shock factor 1 (HSF1) is activated, and the heat shock response (HSR) is elicited. To better understand the molecular regulation of the HSR, we used 2D-PAGE-based proteome analysis to screen for heat shock-induced post-translationally modified cellular proteins. Our analysis revealed that two protein spots typically present on 2D-PAGE gels and containing heterogeneous nuclear ribonucleoprotein K (hnRNP K) with trioxidized Cys132 disappeared after the heat shock treatment and reappeared during recovery, but the total amount of hnRNP K protein remained unchanged. We next tested whether hnRNP K plays a role in HSR by regulating HSF1 and found that hnRNP K inhibits HSF1 activity, resulting in reduced expression of hsp70 and hsp27 mRNAs. hnRNP K also reduced binding affinity of HSF1 to the heat shock element by directly interacting with HSF1 but did not affect HSF1 phosphorylation-dependent activation or nuclear localization. hnRNP K lost its ability to induce these effects when its Cys132 was substituted with Ser, Asp, or Glu. These findings suggest that hnRNP K inhibits transcriptional activity of HSF1 by inhibiting its binding to heat shock element and that the oxidation status of Cys132 in hnRNP K is critical for this inhibition. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  18. Presence of autoantibodies against HeLa small nuclear ribonucleoproteins in chagasic and non-chagasic cardiac patients

    Directory of Open Access Journals (Sweden)

    M.C. Bosetto

    2004-01-01

    Full Text Available We detected anti-human small nuclear ribonucleoprotein (snRNP autoantibodies in chagasic patients by different immunological methods using HeLa snRNPs. ELISA with Trypanosoma cruzi total lysate antigen or HeLa human U small nuclear ribonucleoproteins (UsnRNPs followed by incubation with sera from chronic chagasic and non-chagasic cardiac patients was used to screen and compare serum reactivity. Western blot analysis using a T. cruzi total cell extract was also performed in order to select some sera for Western blot and immunoprecipitation assays with HeLa nuclear extract. ELISA showed that 73 and 95% of chronic chagasic sera reacted with HeLa UsnRNPs and T. cruzi antigens, respectively. The Western blot assay demonstrated that non-chagasic cardiac sera reacted with high molecular weight proteins present in T. cruzi total extract, probably explaining the 31% reactivity found by ELISA. However, these sera reacted weakly with HeLa UsnRNPs, in contrast to the chagasic sera, which showed autoantibodies with human Sm (from Stefanie Smith, the first patient in whom this activity was identified proteins (B/B', D1, D2, D3, E, F, and G UsnRNP. Immunoprecipitation reactions using HeLa nuclear extracts confirmed the reactivity of chagasic sera and human UsnRNA/RNPs, while the other sera reacted weakly only with U1snRNP. These findings agree with previously reported data, thus supporting the idea of the presence of autoimmune antibodies in chagasic patients. Interestingly, non-chagasic cardiac sera also showed reactivity with T. cruzi antigen and HeLa UsnRNPs, which suggests that individuals with heart disease of unknown etiology may develop autoimmune antibodies at any time. The detection of UsnRNP autoantibodies in chagasic patients might contribute to our understanding of how they develop upon initial T. cruzi infection.

  19. Proteomics Core

    Data.gov (United States)

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in a...

  20. Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene.

    Directory of Open Access Journals (Sweden)

    Aya Fukuda

    Full Text Available The c-fos gene responds to extracellular stimuli and undergoes robust but transient transcriptional activation. Here we show that heterogeneous nuclear ribonucleoprotein R (hnRNP R facilitates transcription reinitiation of the c-fos promoter in vitro in cooperation with Mediator. Consistently, hnRNP R interacts with the Scaffold components (Mediator, TBP, and TFIIH as well as TFIIB, which recruits RNA polymerase II (Pol II and TFIIF to Scaffold. The cooperative action of hnRNP R and Mediator is diminished by the cyclin-dependent kinase 8 (CDK8 module, which is comprised of CDK8, Cyclin C, MED12 and MED13 of the Mediator subunits. Interestingly, we find that the length of the G-free cassettes, and thereby their transcripts, influences the hnRNP R-mediated facilitation of reinitiation. Indeed, indicative of a possible role of the transcript in facilitating transcription reinitiation, the RNA transcript produced from the G-free cassette interacts with hnRNP R through its RNA recognition motifs (RRMs and arginine-glycine-glycine (RGG domain. Mutational analyses of hnRNP R indicate that facilitation of initiation and reinitiation requires distinct domains of hnRNP R. Knockdown of hnRNP R in mouse cells compromised rapid induction of the c-fos gene but did not affect transcription of constitutive genes. Together, these results suggest an important role for hnRNP R in regulating robust response of the c-fos gene.

  1. Cloning of the cDNA for U1 small nuclear ribonucleoprotein particle 70K protein from Arabidopsis thaliana

    Science.gov (United States)

    Reddy, A. S.; Czernik, A. J.; An, G.; Poovaiah, B. W.

    1992-01-01

    We cloned and sequenced a plant cDNA that encodes U1 small nuclear ribonucleoprotein (snRNP) 70K protein. The plant U1 snRNP 70K protein cDNA is not full length and lacks the coding region for 68 amino acids in the amino-terminal region as compared to human U1 snRNP 70K protein. Comparison of the deduced amino acid sequence of the plant U1 snRNP 70K protein with the amino acid sequence of animal and yeast U1 snRNP 70K protein showed a high degree of homology. The plant U1 snRNP 70K protein is more closely related to the human counter part than to the yeast 70K protein. The carboxy-terminal half is less well conserved but, like the vertebrate 70K proteins, is rich in charged amino acids. Northern analysis with the RNA isolated from different parts of the plant indicates that the snRNP 70K gene is expressed in all of the parts tested. Southern blotting of genomic DNA using the cDNA indicates that the U1 snRNP 70K protein is coded by a single gene.

  2. Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza.

    Science.gov (United States)

    Monod, Alexandre; Swale, Christopher; Tarus, Bogdan; Tissot, Alice; Delmas, Bernard; Ruigrok, Rob Wh; Crépin, Thibaut; Slama-Schwok, Anny

    2015-04-01

    Influenza viruses are a threat to human health. There are presently only two methods for treating influenza: vaccines, which require yearly updates, and two classes of antivirals that suffer with the problem of resistance by current human influenza viruses; this is especially the case with amantadine and rimantadine. Consequently, there is an urgent need for the development of new antivirals with new mechanisms of action. In this review, the authors focus on viral protein domains, their associated activity and their inhibition by small molecules defined by a structure-based design with a special emphasis on the ribonucleoprotein complex and its inhibitors. Several new classes of antiviral candidates targeting viral replication through individual domains of the polymerase and the nucleoprotein (NP) have been developed through structure-based design. To date, the antivirals targeting neuraminidase are by far the most developed and potent. Antiviral candidates targeting the NP and polymerase domains are in the pipeline but their pharmacokinetics needs further studies. The recently published structures of the polymerase expand the possibilities for development of new antivirals. Combination therapies targeting conserved viral targets and new cellular proteins or exploiting drug promiscuity hold promises to fight against the emergence of resistance.

  3. Ice cores

    DEFF Research Database (Denmark)

    Svensson, Anders

    2014-01-01

    Ice cores from Antarctica, from Greenland, and from a number of smaller glaciers around the world yield a wealth of information on past climates and environments. Ice cores offer unique records on past temperatures, atmospheric composition (including greenhouse gases), volcanism, solar activity......, dustiness, and biomass burning, among others. In Antarctica, ice cores extend back more than 800,000 years before present (Jouzel et al. 2007), whereas. Greenland ice cores cover the last 130,000 years...

  4. Heterogeneous Nuclear Ribonucleoprotein K Supports Vesicular Stomatitis Virus Replication by Regulating Cell Survival and Cellular Gene Expression

    Science.gov (United States)

    Dinh, Phat X.; Das, Anshuman; Franco, Rodrigo

    2013-01-01

    The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a member of the family of hnRNPs and was recently shown in a genome-wide small interfering RNA (siRNA) screen to support vesicular stomatitis virus (VSV) growth. To decipher the role of hnRNP K in VSV infection, we conducted studies which suggest that the protein is required for VSV spreading. Virus binding to cells, entry, and nucleocapsid uncoating steps were not adversely affected in the absence of hnRNP K, whereas viral genome transcription and replication were reduced slightly. These results indicate that hnRNP K is likely involved in virus assembly and/or release from infected cells. Further studies showed that hnRNP K suppresses apoptosis of virus-infected cells, resulting in increased cell survival during VSV infection. The increased survival of the infected cells was found to be due to the suppression of proapoptotic proteins such as Bcl-XS and Bik in a cell-type-dependent manner. Additionally, depletion of hnRNP K resulted in not only significantly increased levels of T-cell-restricted intracellular antigen 1 (TIA1) but also switching of the expression of the two isoforms of the protein (TIA1a and TIA1b), both of which inhibited VSV replication. hnRNP K was also found to support expression of several cellular proteins known to be required for VSV infection. Overall, our studies demonstrate hnRNP K to be a multifunctional protein that supports VSV infection via its role(s) in suppressing apoptosis of infected cells, inhibiting the expression of antiviral proteins, and maintaining the expression of proteins required for the virus. PMID:23843646

  5. The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase.

    Directory of Open Access Journals (Sweden)

    Fei Song

    Full Text Available Ribonucleoprotein (RNP complexes form around nascent RNA during transcription to facilitate proper transcriptional elongation, RNA processing, and nuclear export. RNPs are highly heterogeneous, and different types of RNPs tend to package functionally related transcripts. These observations have inspired the hypothesis that RNP mediated mechanisms help specify coordinated gene expression. This hypothesis is supported by the observation that mutations in RNP components can cause defects in specific developmental pathways. How RNP biogenesis itself is regulated, however, is not well understood. The evolutionarily conserved THO RNP complex functions early during transcription to package nascent transcripts and facilitate subsequent RNP biogenesis. THO deficiency compromises transcriptional elongation as well as RNP mediated events like 3' end formation and nuclear export for some transcripts. Using molecularly manipulated cells and in vitro reconstituted biochemical reactions, we demonstrate that the essential THO protein component encoded by the Thoc1 gene is poly-ubiquitinated by the NEDD4-1 E3 ubiquitin ligase. Poly-ubiquitinated pThoc1 is degraded by the proteasome. These results indicate THO activity is regulated by the ubiquitin-proteasome pathway, and that this regulation is evolutionarily conserved between yeast and mammals. Manipulation of NEDD4-1 levels has modest effects on Thoc1 protein levels under steady state conditions, but destabilization of Thoc1 protein upon treatment with a transcriptional elongation inhibitor is dependent on NEDD4-1. This suggests NEDD4-1 functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO activity.

  6. Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins

    Directory of Open Access Journals (Sweden)

    Lia Carolina Soares Medeiros

    2017-11-01

    Full Text Available Trypanosomatids (order Kinetoplastida, including the human pathogens Trypanosoma cruzi (agent of Chagas disease, Trypanosoma brucei, (African sleeping sickness, and Leishmania (leishmaniasis, affect millions of people and animals globally. T. cruzi is considered one of the least studied and most poorly understood tropical disease-causing parasites, in part because of the relative lack of facile genetic engineering tools. This situation has improved recently through the application of clustered regularly interspaced short palindromic repeats–CRISPR-associated protein 9 (CRISPR-Cas9 technology, but a number of limitations remain, including the toxicity of continuous Cas9 expression and the long drug marker selection times. In this study, we show that the delivery of ribonucleoprotein (RNP complexes composed of recombinant Cas9 from Staphylococcus aureus (SaCas9, but not from the more routinely used Streptococcus pyogenes Cas9 (SpCas9, and in vitro-transcribed single guide RNAs (sgRNAs results in rapid gene edits in T. cruzi and other kinetoplastids at frequencies approaching 100%. The highly efficient genome editing via SaCas9/sgRNA RNPs was obtained for both reporter and endogenous genes and observed in multiple parasite life cycle stages in various strains of T. cruzi, as well as in T. brucei and Leishmania major. RNP complex delivery was also used to successfully tag proteins at endogenous loci and to assess the biological functions of essential genes. Thus, the use of SaCas9 RNP complexes for gene editing in kinetoplastids provides a simple, rapid, and cloning- and selection-free method to assess gene function in these important human pathogens.

  7. Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs.

    Directory of Open Access Journals (Sweden)

    Francesca Gabanella

    2007-09-01

    Full Text Available Spinal muscular atrophy (SMA is a motor neuron disease caused by reduced levels of the survival motor neuron (SMN protein. SMN together with Gemins2-8 and unrip proteins form a macromolecular complex that functions in the assembly of small nuclear ribonucleoproteins (snRNPs of both the major and the minor splicing pathways. It is not known whether the levels of spliceosomal snRNPs are decreased in SMA. Here we analyzed the consequence of SMN deficiency on snRNP metabolism in the spinal cord of mouse models of SMA with differing phenotypic severities. We demonstrate that the expression of a subset of Gemin proteins and snRNP assembly activity are dramatically reduced in the spinal cord of severe SMA mice. Comparative analysis of different tissues highlights a similar decrease in SMN levels and a strong impairment of snRNP assembly in tissues of severe SMA mice, although the defect appears smaller in kidney than in neural tissue. We further show that the extent of reduction in both Gemin proteins expression and snRNP assembly activity in the spinal cord of SMA mice correlates with disease severity. Remarkably, defective SMN complex function in snRNP assembly causes a significant decrease in the levels of a subset of snRNPs and preferentially affects the accumulation of U11 snRNP--a component of the minor spliceosome--in tissues of severe SMA mice. Thus, impairment of a ubiquitous function of SMN changes the snRNP profile of SMA tissues by unevenly altering the normal proportion of endogenous snRNPs. These findings are consistent with the hypothesis that SMN deficiency affects the splicing machinery and in particular the minor splicing pathway of a rare class of introns in SMA.

  8. Heterogeneous nuclear ribonucleoprotein K upregulates the kinetochore complex component NUF2 and promotes the tumorigenicity of colon cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Sugimasa, Hironobu; Taniue, Kenzui [Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-0032 (Japan); Kurimoto, Akiko [Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-0032 (Japan); Oncology Research Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710 (Japan); Takeda, Yasuko; Kawasaki, Yoshihiro [Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-0032 (Japan); Akiyama, Tetsu, E-mail: akiyama@iam.u-tokyo.ac.jp [Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-0032 (Japan)

    2015-03-27

    Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a multi-functional protein involved in transcription, mRNA splicing, mRNA stabilization and translation. Although hnRNP K has been suggested to play a role in the development of many cancers, its molecular function in colorectal cancer has remained elusive. Here we show that hnRNP K plays an important role in the mitotic process in HCT116 colon cancer cells. Furthermore, we demonstrate that hnRNP K directly transactivates the NUF2 gene, the product of which is a component of the NDC80 kinetochore complex and which is known to be critical for a stable spindle microtubule-kinetochore attachment. In addition, knockdown of both hnRNP K and NUF2 caused failure in metaphase chromosome alignment and drastic decrease in the growth of colon cancer cells. These results suggest that the hnRNP K-NUF2 axis is important for the mitotic process and proliferation of colon cancer cells and that this axis could be a target for the therapy of colon cancer. - Highlights: • hnRNP K is required for the tumorigenicity of colon cancer cells. • hnRNP K binds to the promoter region of NUF2 and activates its transcription. • NUF2 expression is correlated with hnRNP K expression in colorectal cancer tissue. • hnRNP K and NUF2 are required for metaphase chromosome alignment. • The hnRNP K-NUF2 axis is important for the proliferation of colon cancer cells.

  9. A novel SDS-stable dimer of a heterogeneous nuclear ribonucleoprotein at presynaptic terminals of squid neurons.

    Science.gov (United States)

    Lico, D T P; Lopes, G S; Brusco, J; Rosa, J C; Gould, R M; De Giorgis, J A; Larson, R E

    2015-08-06

    The presence of mRNAs in synaptic terminals and their regulated translation are important factors in neuronal communication and plasticity. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in the translocation, stability, and subcellular localization of mRNA and the regulation of its translation. Defects in these processes and mutations in components of the hnRNP complexes have been related to the formation of cytoplasmic inclusion bodies and neurodegenerative diseases. Despite much data on mRNA localization and evidence for protein synthesis, as well as the presence of translation machinery, in axons and presynaptic terminals, the identity of RNA-binding proteins involved in RNA transport and function in presynaptic regions is lacking. We previously characterized a strongly basic RNA-binding protein (p65), member of the hnRNPA/B subfamily, in squid presynaptic terminals. Intriguingly, in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), p65 migrated as a 65-kDa protein, whereas members of the hnRNPA/B family typically have molecular masses ranging from 35 to 42kDa. In this report we present further biochemical and molecular characterization that shows endogenous p65 to be an SDS-stable dimer composed of ∼37-kDa hnRNPA/B-like subunits. We cloned and expressed a recombinant protein corresponding to squid hnRNPA/B-like protein and showed its propensity to aggregate and form SDS-stable dimers in vitro. Our data suggest that this unique hnRNPA/B-like protein co-localizes with synaptic vesicle protein 2 and RNA-binding protein ELAV and thus may serve as a link between local mRNA processing and presynaptic function and regulation. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  10. Transformer core

    NARCIS (Netherlands)

    Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

    2008-01-01

    A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

  11. Transformer core

    NARCIS (Netherlands)

    Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

    2010-01-01

    A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

  12. Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes

    DEFF Research Database (Denmark)

    Honoré, B; Rasmussen, H H; Vorum, H

    1995-01-01

    Molecular cDNA cloning, two-dimensional gel immunoblotting, and amino acid microsequencing identified three sequence-unique and distinct proteins that constitute a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins corresponding to hnRNPs H, H', and F. These proteins share......%, respectively. The three proteins contain three repeats, which we denote quasi-RRMs (qRRMs) since they have a remote similarity to the RNA recognition motif (RRM). The three qRRMs of hnRNP H, with a few additional NH2-terminal amino acids, were constructed by polymerase chain reaction amplification and used...

  13. The C proteins of HeLa 40S nuclear ribonucleoprotein particles exist as anisotropic tetramers of (C1)3 C2.

    OpenAIRE

    Barnett, S F; Friedman, D L; LeStourgeon, W M

    1989-01-01

    The C proteins (C1 and C2) of HeLa 40S heterogeneous nuclear ribonucleoprotein particles copurify under native conditions as a stable complex with a fixed molar protein ratio (S.F. Barnett, W.M. LeStourgeon, and D.L. Friedman, J. Biochem. Biophys. Methods 16:87-97, 1988). Gel filtration chromatography and velocity sedimentation analyses of these complexes revealed a large Stokes radius (6.2 nm) and a sedimentation coefficient of 5.8S. On the basis of these values and a partial specific volume...

  14. Cytosolic and Nuclear Delivery of CRISPR/Cas9-ribonucleoprotein for Gene Editing Using Arginine Functionalized Gold Nanoparticles.

    Science.gov (United States)

    Mout, Rubul; Rotello, Vincent M

    2017-10-20

    In this protocol, engineered Cas9-ribonucleoprotein (Cas9 protein and sgRNA, together called Cas9-RNP) and gold nanoparticles are used to make nanoassemblies that are employed to deliver Cas9-RNP into cell cytoplasm and nucleus. Cas9 protein is engineered with an N-terminus glutamic acid tag (E-tag or En, where n = the number of glutamic acid in an E-tag and usually n = 15 or 20), C-terminus nuclear localizing signal (NLS), and a C-terminus 6xHis-tag. [Cas9En hereafter] To use this protocol, the first step is to generate the required materials (gold nanoparticles, recombinant Cas9En, and sgRNA). Laboratory-synthesis of gold nanoparticles can take up to a few weeks, but can be synthesized in large batches that can be used for many years without compromising the quality. Cas9En can be cloned from a regular SpCas9 gene (Addgene plasmid id = 47327), and expressed and purified using standard laboratory procedures which are not a part of this protocol. Similarly, sgRNA can be laboratory-synthesized using in vitro transcription from a template gene (Addgene plasmid id = 51765) or can be purchased from various sources. Once these materials are ready, it takes about ~30 min to make the Cas9En-RNP complex and 10 min to make the Cas9En-RNP/nanoparticles nanoassemblies, which are immediately used for delivery (Figure 1). Complete delivery (90-95% cytoplasmic and nuclear delivery) is achieved in less than 3 h. Follow-up editing experiments require additional time based on users' need. Synthesis of arginine functionalized gold nanoparticles (ArgNPs) (Yang et al ., 2011), expression of recombinant Cas9En, and in vitro synthesis of sgRNA is reported elsewhere (Mout et al ., 2017). We report here only the generation of the delivery vehicle i.e. , the fabrication of Cas9En-RNP/ArgNPs nanoassembly.

  15. ANTI-HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN B1 (ANTI-RA33 ANTIBODIES IN RHEUMATOID ARTHRITIS AND SYSTEMIC SCLEROSIS

    Directory of Open Access Journals (Sweden)

    P. A. Kuznetsova

    2017-01-01

    Full Text Available Anti-heterogeneous nuclear ribonucleoprotein (RNP autoantibodies (AAbs are encountered in many autoimmune rheumatic diseases (ARDs. The potential diagnostic value of the RA33 AAb complex consisting of RNP A2 and alternative domains of the splicing proteins RNP B1 and RNP B2 is now of interest to rheumatologists. Subjects and methods. The authors studied the frequency of anti-RNP B1 AAbs in 300 patients with systemic ARDs, including those with rheumatoid arthritis (RA, ankylosing spondylitis (AS, systemic lupus erythematosus (SLE, systemic sclerosis (SSc, and Sjö gren's syndrome (SS and in 53 people without ARDs, who constituted a control group. Serum anti-RNP B1 AAbs were assessed by enzyme immunoassay. Results and discussion. The frequency of anti-RNP B1 AAbs in patients with ARDs was much higher than that in the control group: 170/300 (56.6% and 8/53 (13% patients, respectively. Anti-RNP B1 AAbs were detected in 78.5% (113/144 of the patients with RA; 40.3% (23/57 of those with AS, in 67.5% (27/40 of those with SSc, in 36.4% (16/44 of those with SLE, and in 13.3% (2/15 of those with SS. The diagnostic sensitivity of the marker for RA was 78.5%, its diagnostic specificity was 84.9%; the likelihood ratio of positive and negative results was 5.24 and 0.24, respectively. In the patients with RA, the level of anti-RNP B1 AAbs significantly correlated with that of C-reactive protein and erythrocyte sedimentation rate, while in those with SSc the detection of anti-RNP B1 AAbs was related to the rigidity of the vascular wall and the presence of hypertension. The frequency of anti-RNP B1 AAbs among the RA patients seronegative for rheumatoid factor and anti-cyclic citrullinated peptide antibodies was 15.4%. Conclusion. Anti-RNP B1 AAs are a useful laboratory marker (with the upper limit of the normal range being 3.3 U/ml, but are of limited value in the diagnosis of RA. Anti-RNP B1 AAbs may be regarded as an additional diagnostic marker for RA.

  16. Core BPEL

    DEFF Research Database (Denmark)

    Hallwyl, Tim; Højsgaard, Espen

    extensions. Combined with the fact that the language definition does not provide a formal semantics, it is an arduous task to work formally with the language (e.g. to give an implementation). In this paper we identify a core subset of the language, called Core BPEL, which has fewer and simpler constructs......, does not allow omissions, and does not contain ignorable elements. We do so by identifying syntactic sugar, including default values, and ignorable elements in WS-BPEL. The analysis results in a translation from the full language to the core subset. Thus, we reduce the effort needed for working...... formally with WS-BPEL, as one, without loss of generality, need only consider the much simpler Core BPEL. This report may also be viewed as an addendum to the WS-BPEL standard specification, which clarifies the WS-BPEL syntax and presents the essential elements of the language in a more concise way...

  17. Ice Cores

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Records of past temperature, precipitation, atmospheric trace gases, and other aspects of climate and environment derived from ice cores drilled on glaciers and ice...

  18. Core benefits

    National Research Council Canada - National Science Library

    Keith, Brian W

    2010-01-01

    This SPEC Kit explores the core employment benefits of retirement, and life, health, and other insurance -benefits that are typically decided by the parent institution and often have significant governmental regulation...

  19. Hollow Core?

    Science.gov (United States)

    Qiao, G. J.; Liu, J. F.; Wang, Yang; Wu, X. J.; Han, J. L.

    We carried out the Gaussian fitting to the profile of PSR B1237+25 and found that six components rather than five are necessary to make a good fit. In the central part, we found that the core emission is not filled pencil beam but is a small hollow cone. This implies that the impact angle could be $\\beta<0.5^\\circ$. The ``hollow core'' is in agreement with Inverse Compton Scattering model of radio pulsars.

  20. Mechanistic and Structural Studies of Protein-Only RNase P Compared to Ribonucleoproteins Reveal the Two Faces of the Same Enzymatic Activity

    Directory of Open Access Journals (Sweden)

    Cédric Schelcher

    2016-06-01

    Full Text Available RNase P, the essential activity that performs the 5′ maturation of tRNA precursors, can be achieved either by ribonucleoproteins containing a ribozyme present in the three domains of life or by protein-only enzymes called protein-only RNase P (PRORP that occur in eukaryote nuclei and organelles. A fast growing list of studies has investigated three-dimensional structures and mode of action of PRORP proteins. Results suggest that similar to ribozymes, PRORP proteins have two main domains. A clear functional analogy can be drawn between the specificity domain of the RNase P ribozyme and PRORP pentatricopeptide repeat domain, and between the ribozyme catalytic domain and PRORP N4BP1, YacP-like Nuclease domain. Moreover, both types of enzymes appear to dock with the acceptor arm of tRNA precursors and make specific contacts with the corner of pre-tRNAs. While some clear differences can still be delineated between PRORP and ribonucleoprotein (RNP RNase P, the two types of enzymes seem to use, fundamentally, the same catalytic mechanism involving two metal ions. The occurrence of PRORP and RNP RNase P represents a remarkable example of convergent evolution. It might be the unique witness of an ongoing replacement of catalytic RNAs by proteins for enzymatic activities.

  1. Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A viruses.

    Directory of Open Access Journals (Sweden)

    Karry L K Ngai

    Full Text Available Avian influenza viruses pose a serious pandemic threat to humans. Better knowledge on cross-species adaptation is important. This study examined the replication and transcription efficiency of ribonucleoprotein complexes reconstituted by plasmid co-transfection between H5N1, H1N1pdm09 and H3N2 influenza A viruses, and to identify mutations in the RNA polymerase subunit that affect human adaptation. Viral RNA polymerase subunits PB1, PB2, PA and NP derived from influenza viruses were co-expressed with pPolI-vNP-Luc in human cells, and with its function evaluated by luciferase reporter assay. A quantitative RT-PCR was used to measure vRNA, cRNA, and mRNA levels for assessing the replication and transcription efficiency. Mutations in polymerase subunit were created to identify signature of increased human adaptability. H5N1 ribonucleoprotein complexes incorporated with PB2 derived from H1N1pdm09 and H3N2 viruses increased the polymerase activity in human cells. Furthermore, single amino acid substitutions at PB2 of H5N1 could affect polymerase activity in a temperature-dependent manner. By using a highly sensitive quantitative reverse transcription-polymerase chain reaction, an obvious enhancement in replication and transcription activities of ribonucleoproteins was observed by the introduction of lysine at residue 627 in the H5N1 PB2 subunit. Although less strongly in polymerase activity, E158G mutation appeared to alter the accumulation of H5N1 RNA levels in a temperature-dependent manner, suggesting a temperature-dependent mechanism in regulating transcription and replication exists. H5N1 viruses can adapt to humans either by acquisition of PB2 from circulating human-adapted viruses through reassortment, or by mutations at critical sites in PB2. This information may help to predict the pandemic potential of newly emerged influenza strains, and provide a scientific basis for stepping up surveillance measures and vaccine production.

  2. Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides.

    Science.gov (United States)

    Rivera-Torres, Natalia; Banas, Kelly; Bialk, Pawel; Bloh, Kevin M; Kmiec, Eric B

    2017-01-01

    CRISPR/Cas9 and single-stranded DNA oligonucleotides (ssODNs) have been used to direct the repair of a single base mutation in human genes. Here, we examine a method designed to increase the precision of RNA guided genome editing in human cells by utilizing a CRISPR/Cas9 ribonucleoprotein (RNP) complex to initiate DNA cleavage. The RNP is assembled in vitro and induces a double stranded break at a specific site surrounding the mutant base designated for correction by the ssODN. We use an integrated mutant eGFP gene, bearing a single base change rendering the expressed protein nonfunctional, as a single copy target in HCT 116 cells. We observe significant gene correction activity of the mutant base, promoted by the RNP and single-stranded DNA oligonucleotide with validation through genotypic and phenotypic readout. We demonstrate that all individual components must be present to obtain successful gene editing. Importantly, we examine the genotype of individually sorted corrected and uncorrected clonally expanded cell populations for the mutagenic footprint left by the action of these gene editing tools. While the DNA sequence of the corrected population is exact with no adjacent sequence modification, the uncorrected population exhibits heterogeneous mutagenicity with a wide variety of deletions and insertions surrounding the target site. We designate this type of DNA aberration as on-site mutagenicity. Analyses of two clonal populations bearing specific DNA insertions surrounding the target site, indicate that point mutation repair has occurred at the level of the gene. The phenotype, however, is not rescued because a section of the single-stranded oligonucleotide has been inserted altering the reading frame and generating truncated proteins. These data illustrate the importance of analysing mutagenicity in uncorrected cells. Our results also form the basis of a simple model for point mutation repair directed by a short single-stranded DNA oligonucleotides and

  3. Non-canonical binding interactions of the RNA recognition motif (RRM) domains of P34 protein modulate binding within the 5S ribonucleoprotein particle (5S RNP).

    Science.gov (United States)

    Kamina, Anyango D; Williams, Noreen

    2017-01-01

    RNA binding proteins are involved in many aspects of RNA metabolism. In Trypanosoma brucei, our laboratory has identified two trypanosome-specific RNA binding proteins P34 and P37 that are involved in the maturation of the 60S subunit during ribosome biogenesis. These proteins are part of the T. brucei 5S ribonucleoprotein particle (5S RNP) and P34 binds to 5S ribosomal RNA (rRNA) and ribosomal protein L5 through its N-terminus and its RNA recognition motif (RRM) domains. We generated truncated P34 proteins to determine these domains' interactions with 5S rRNA and L5. Our analyses demonstrate that RRM1 of P34 mediates the majority of binding with 5S rRNA and the N-terminus together with RRM1 contribute the most to binding with L5. We determined that the consensus ribonucleoprotein (RNP) 1 and 2 sequences, characteristic of canonical RRM domains, are not fully conserved in the RRM domains of P34. However, the aromatic amino acids previously described to mediate base stacking interactions with their RNA target are conserved in both of the RRM domains of P34. Surprisingly, mutation of these aromatic residues did not disrupt but instead enhanced 5S rRNA binding. However, we identified four arginine residues located in RRM1 of P34 that strongly impact L5 binding. These mutational analyses of P34 suggest that the binding site for 5S rRNA and L5 are near each other and specific residues within P34 regulate the formation of the 5S RNP. These studies show the unique way that the domains of P34 mediate binding with the T. brucei 5S RNP.

  4. An efficient strategy for the determination of the three-dimensional architecture of ribonucleoprotein complexes by the combination of a few easily accessible NMR and biochemical data: intermolecular recognition in a U4 spliceosomal complex.

    Science.gov (United States)

    Li, Ping; Kirkpatrick, John; Carlomagno, Teresa

    2009-05-01

    Ribonucleoprotein (RNP) complexes are involved in several cellular processes, including RNA processing, transcription and translation. RNP structures are often dynamic in nature, undergoing significant remodeling during the course of their function. Visualization of the three-dimensional arrangement of single components in the complex and characterization of the intermolecular interactions are essential for understanding the mechanisms of operation. Crystallization either is not always achievable for these highly dynamic RNP particles or requires trimming the complex to a stable, well-structured core that lacks the flexible, regulatory domains. Alternative techniques that can provide structural information for complexes in solution under native conditions, where they retain their natural dynamic properties, are needed. In this study, we explored the possibility of using a combination of NMR, biochemical data and molecular modeling to generate an accurate high-resolution model of RNP complexes. We applied this strategy to the ternary hPrp31 (human Prp31)-15.5K-U4 5'-SL (stem-loop) spliceosomal complex, which, due to its large size and instability and because of the difficulty in obtaining isotopically labeled hPrp31, is not amenable to complete structure determination by NMR. We designed a protocol where the protein-protein interaction surface is defined for 15.5K by NMR data, while the relative orientations of the U4 RNA and the hPrp31 protein are described by mutational and cross-linking data. Using these data in a restrained ensemble docking protocol, we obtained a model for the ternary complex that reveals a novel rationale for the hierarchical assembly of the complex. Comparison of the docking model with the crystal structure recently obtained for a trimmed version of the complex reveals the high accuracy of the docking model, even down to an atomic level. This work shows that the architecture of large RNP complexes is within reach by NMR investigation in

  5. Odorant Sensory Input Modulates DNA Secondary Structure Formation and Heterogeneous Ribonucleoprotein Recruitment on the Tyrosine Hydroxylase and Glutamic Acid Decarboxylase 1 Promoters in the Olfactory Bulb.

    Science.gov (United States)

    Wang, Meng; Cai, Elizabeth; Fujiwara, Nana; Fones, Lilah; Brown, Elizabeth; Yanagawa, Yuchio; Cave, John W

    2017-05-03

    Adaptation of neural circuits to changes in sensory input can modify several cellular processes within neurons, including neurotransmitter biosynthesis levels. For a subset of olfactory bulb interneurons, activity-dependent changes in GABA are reflected by corresponding changes in Glutamate decarboxylase 1 ( Gad1 ) expression levels. Mechanisms regulating Gad1 promoter activity are poorly understood, but here we show that a conserved G:C-rich region in the mouse Gad1 proximal promoter region both recruits heterogeneous nuclear ribonucleoproteins (hnRNPs) that facilitate transcription and forms single-stranded DNA secondary structures associated with transcriptional repression. This promoter architecture and function is shared with Tyrosine hydroxylase ( Th ), which is also modulated by odorant-dependent activity in the olfactory bulb. This study shows that the balance between DNA secondary structure formation and hnRNP binding on the mouse Th and Gad1 promoters in the olfactory bulb is responsive to changes in odorant-dependent sensory input. These findings reveal that Th and Gad1 share a novel transcription regulatory mechanism that facilitates sensory input-dependent regulation of dopamine and GABA expression. SIGNIFICANCE STATEMENT Adaptation of neural circuits to changes in sensory input can modify several cellular processes within neurons, including neurotransmitter biosynthesis levels. This study shows that transcription of genes encoding rate-limiting enzymes for GABA and dopamine biosynthesis ( Gad1 and Th , respectively) in the mammalian olfactory bulb is regulated by G:C-rich regions that both recruit heterogeneous nuclear ribonucleoproteins (hnRNPs) to facilitate transcription and form single-stranded DNA secondary structures associated with repression. hnRNP binding and formation of DNA secondary structure on the Th and Gad1 promoters are mutually exclusive, and odorant sensory input levels regulate the balance between these regulatory features. These

  6. A natural component from Euphorbia humifusa Willd displays novel, broad-spectrum anti-influenza activity by blocking nuclear export of viral ribonucleoprotein

    Energy Technology Data Exchange (ETDEWEB)

    Chang, So Young; Park, Ji Hoon [Respiratory Viruses Research Laboratory, Discovery Biology Department, Institut Pasteur Korea, 16, Daewangpangyo-ro 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-400 (Korea, Republic of); Kim, Young Ho; Kang, Jong Seong [College of Pharmacy, Chungnam National University, Daejeon, 305-764 (Korea, Republic of); Min, Ji-Young, E-mail: jiyoung.min@ip-korea.org [Respiratory Viruses Research Laboratory, Discovery Biology Department, Institut Pasteur Korea, 16, Daewangpangyo-ro 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-400 (Korea, Republic of)

    2016-03-04

    The need to develop anti-influenza drugs with novel antiviral mechanisms is urgent because of the rapid rate of antigenic mutation and the emergence of drug-resistant viruses. We identified a novel anti-influenza molecule by screening 861 plant-derived natural components using a high-throughput image-based assay that measures inhibition of the influenza virus infection. 1,3,4,6-tetra-O-galloyl-β-D-glucopyranoside (TGBG) from Euphorbia humifusa Willd showed broad-spectrum anti-influenza activity against two seasonal influenza A strains, A/California/07/2009 (H1N1) and A/Perth/16/2009 (H3N2), and seasonal influenza B strain B/Florida/04/2006. We investigated the mode of action of TGBG using neuraminidase activity inhibition and time-of-addition assays, which evaluate the viral release and entry steps, respectively. We found that TGBG exhibits a novel antiviral mechanism that differs from the FDA-approved anti-influenza drugs oseltamivir which inhibits viral release, and amantadine which inhibits viral entry. Immunofluorescence assay demonstrated that TGBG significantly inhibits nuclear export of influenza nucleoproteins (NP) during the early stages of infection causing NP to accumulate in the nucleus. In addition, influenza-induced activation of the Akt signaling pathway was suppressed by TGBG in a dose-dependent manner. These data suggest that a putative mode of action of TGBG involves inhibition of viral ribonucleoprotein (vRNP) export from the nucleus to the cytoplasm consequently disrupting the assembly of progeny virions. In summary, TGBG has potential as novel anti-influenza therapeutic with a novel mechanism of action. - Highlights: • The plant-derived natural product TGBG has broad-spectrum antiviral activity against seasonal influenza A and B viruses. • TGBG has a novel anti-viral mechanism of action that from differs from the currently available anti-influenza drugs. • TGBG hinders nuclear export of the influenza virus ribonucleoprotein (v

  7. Overexpression of an Arabidopsis heterogeneous nuclear ribonucleoprotein gene, AtRNP1, affects plant growth and reduces plant tolerance to drought and salt stresses

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhenyu, E-mail: wzy72609@163.com [Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730030 (China); Zhao, Xiuyang, E-mail: xiuzh@psb.vib-ugent.be [Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730030 (China); Wang, Bing, E-mail: wangbing@ibcas.ac.cn [Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730030 (China); Liu, Erlong, E-mail: liuel14@lzu.edu.cn [Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730030 (China); Chen, Ni, E-mail: 63710156@qq.com [Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730030 (China); Zhang, Wei, E-mail: wzhang1216@yahoo.com [Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai 200444 (China); Liu, Heng, E-mail: hengliu@lzu.edu.cn [Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730030 (China)

    2016-04-01

    Heterogeneous nuclear ribonucleoproteins (hnRNPs) participate in diverse regulations of plant growth and environmental stress responses. In this work, an Arabidopsis hnRNP of unknown function, AtRNP1, was investigated. We found that AtRNP1 gene is highly expressed in rosette and cauline leaves, and slightly induced under drought, salt, osmotic and ABA stresses. AtRNP1 protein is localized to both the nucleus and cytoplasm. We performed homologous overexpression of AtRNP1 and found that the transgenic plants showed shortened root length and plant height, and accelerated flowering. In addition, the transgenic plants also showed reduced tolerance to drought, salt, osmotic and ABA stresses. Further studies revealed that under both normal and stress conditions, the proline contents in the transgenic plants are markedly decreased, associated with reduced expression levels of a proline synthase gene and several stress-responsive genes. These results suggested that the overexpression of AtRNP1 negatively affects plant growth and abiotic stress tolerance. - Highlights: • AtRNP1 is a widely expressed gene and its expression is slightly induced under abiotic stresses. • AtRNP1 protein is localized to both the nucleus and cytoplasm. • Overexpression of AtRNP1 affects plant growth. • Overexpression of AtRNP1 reduces plant tolerance to drought and salt stresses. • AtRNP1 overexpression plants show decreased proline accumulation and stress-responsive gene expressions.

  8. SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3′-End Formation of Histone mRNAs

    Directory of Open Access Journals (Sweden)

    Sarah Tisdale

    2013-12-01

    Full Text Available Spinal muscular atrophy (SMA is a neurodegenerative disease caused by a deficiency in the survival motor neuron (SMN protein. SMN mediates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs and possibly other RNPs. Here, we investigated SMN requirement for the biogenesis and function of U7—an snRNP specialized in the 3′-end formation of replication-dependent histone mRNAs that normally are not polyadenylated. We show that SMN deficiency impairs U7 snRNP assembly and decreases U7 levels in mammalian cells. The SMN-dependent U7 reduction affects endonucleolytic cleavage of histone mRNAs leading to abnormal accumulation of 3′-extended and polyadenylated transcripts followed by downstream changes in histone gene expression. Importantly, SMN deficiency induces defects of histone mRNA 3′-end formation in both SMA mice and human patients. These findings demonstrate that SMN is essential for U7 biogenesis and histone mRNA processing in vivo and identify an additional RNA pathway disrupted in SMA.

  9. Animal MRI Core

    Data.gov (United States)

    Federal Laboratory Consortium — The Animal Magnetic Resonance Imaging (MRI) Core develops and optimizes MRI methods for cardiovascular imaging of mice and rats. The Core provides imaging expertise,...

  10. A comprehensive analysis of 3′ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation

    Science.gov (United States)

    Gruber, Andreas J.; Schmidt, Ralf; Gruber, Andreas R.; Martin, Georges; Ghosh, Souvik; Belmadani, Manuel; Keller, Walter

    2016-01-01

    Alternative polyadenylation (APA) is a general mechanism of transcript diversification in mammals, which has been recently linked to proliferative states and cancer. Different 3′ untranslated region (3′ UTR) isoforms interact with different RNA-binding proteins (RBPs), which modify the stability, translation, and subcellular localization of the corresponding transcripts. Although the heterogeneity of pre-mRNA 3′ end processing has been established with high-throughput approaches, the mechanisms that underlie systematic changes in 3′ UTR lengths remain to be characterized. Through a uniform analysis of a large number of 3′ end sequencing data sets, we have uncovered 18 signals, six of which are novel, whose positioning with respect to pre-mRNA cleavage sites indicates a role in pre-mRNA 3′ end processing in both mouse and human. With 3′ end sequencing we have demonstrated that the heterogeneous ribonucleoprotein C (HNRNPC), which binds the poly(U) motif whose frequency also peaks in the vicinity of polyadenylation (poly(A)) sites, has a genome-wide effect on poly(A) site usage. HNRNPC-regulated 3′ UTRs are enriched in ELAV-like RBP 1 (ELAVL1) binding sites and include those of the CD47 gene, which participate in the recently discovered mechanism of 3′ UTR–dependent protein localization (UDPL). Our study thus establishes an up-to-date, high-confidence catalog of 3′ end processing sites and poly(A) signals, and it uncovers an important role of HNRNPC in regulating 3′ end processing. It further suggests that U-rich elements mediate interactions with multiple RBPs that regulate different stages in a transcript's life cycle. PMID:27382025

  11. A comprehensive analysis of 3' end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation.

    Science.gov (United States)

    Gruber, Andreas J; Schmidt, Ralf; Gruber, Andreas R; Martin, Georges; Ghosh, Souvik; Belmadani, Manuel; Keller, Walter; Zavolan, Mihaela

    2016-08-01

    Alternative polyadenylation (APA) is a general mechanism of transcript diversification in mammals, which has been recently linked to proliferative states and cancer. Different 3' untranslated region (3' UTR) isoforms interact with different RNA-binding proteins (RBPs), which modify the stability, translation, and subcellular localization of the corresponding transcripts. Although the heterogeneity of pre-mRNA 3' end processing has been established with high-throughput approaches, the mechanisms that underlie systematic changes in 3' UTR lengths remain to be characterized. Through a uniform analysis of a large number of 3' end sequencing data sets, we have uncovered 18 signals, six of which are novel, whose positioning with respect to pre-mRNA cleavage sites indicates a role in pre-mRNA 3' end processing in both mouse and human. With 3' end sequencing we have demonstrated that the heterogeneous ribonucleoprotein C (HNRNPC), which binds the poly(U) motif whose frequency also peaks in the vicinity of polyadenylation (poly(A)) sites, has a genome-wide effect on poly(A) site usage. HNRNPC-regulated 3' UTRs are enriched in ELAV-like RBP 1 (ELAVL1) binding sites and include those of the CD47 gene, which participate in the recently discovered mechanism of 3' UTR-dependent protein localization (UDPL). Our study thus establishes an up-to-date, high-confidence catalog of 3' end processing sites and poly(A) signals, and it uncovers an important role of HNRNPC in regulating 3' end processing. It further suggests that U-rich elements mediate interactions with multiple RBPs that regulate different stages in a transcript's life cycle. © 2016 Gruber et al.; Published by Cold Spring Harbor Laboratory Press.

  12. Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.

    Science.gov (United States)

    Chen, Zhe; Gui, Bin; Zhang, Yu; Xie, Guojia; Li, Wanjin; Liu, Shumeng; Xu, Bosen; Wu, Chongyang; He, Lin; Yang, Jianguo; Yi, Xia; Yang, Xiaohan; Sun, Luyang; Liang, Jing; Shang, Yongfeng

    2017-11-03

    The de novo assembly and post-splicing reassembly of the U4/U6.U5 tri-snRNP remain to be investigated. We report here that ZIP, a protein containing a CCCH-type zinc finger and a G-patch domain, as characterized by us previously, regulates pre-mRNA splicing independent of RNA binding. We found that ZIP physically associates with the U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP). Remarkably, the ZIP-containing tri-snRNP, which has a sedimentation coefficient of ∼35S, is a tri-snRNP that has not been described previously. We also found that the 35S tri-snRNP contains hPrp24, indicative of a state in which the U4/U6 di-snRNP is integrating with the U5 snRNP. We found that the 35S tri-snRNP is enriched in the Cajal body, indicating that it is an assembly intermediate during 25S tri-snRNP maturation. We showed that the 35S tri-snRNP also contains hPrp43, in which ATPase/RNA helicase activities are stimulated by ZIP. Our study identified, for the first time, a tri-snRNP intermediate, shedding new light on the de novo assembly and recycling of the U4/U6.U5 tri-snRNP. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  13. Binding of the heterogeneous ribonucleoprotein K (hnRNP K to the Epstein-Barr virus nuclear antigen 2 (EBNA2 enhances viral LMP2A expression.

    Directory of Open Access Journals (Sweden)

    Henrik Gross

    Full Text Available The Epstein-Barr Virus (EBV -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs. Its Arginine-Glycine (RG repeat element contains either symmetrically or asymmetrically di-methylated arginine residues (SDMA and ADMA, respectively. EBNA2 binds via its SDMA-modified RG-repeat to the survival motor neurons protein (SMN and via the ADMA-RG-repeat to the NP9 protein of the human endogenous retrovirus K (HERV-K (HML-2 Type 1. The hypothesis of this work was that the methylated RG-repeat mimics an epitope shared with cellular proteins that is used for interaction with target structures. With monoclonal antibodies against the modified RG-repeat, we indeed identified cellular homologues that apparently have the same surface structure as methylated EBNA2. With the SDMA-specific antibodies, we precipitated the Sm protein D3 (SmD3 which, like EBNA2, binds via its SDMA-modified RG-repeat to SMN. With the ADMA-specific antibodies, we precipitated the heterogeneous ribonucleoprotein K (hnRNP K. Specific binding of the ADMA- antibody to hnRNP K was demonstrated using E. coli expressed/ADMA-methylated hnRNP K. In addition, we show that EBNA2 and hnRNP K form a complex in EBV- infected B-cells. Finally, hnRNP K, when co-expressed with EBNA2, strongly enhances viral latent membrane protein 2A (LMP2A expression by an unknown mechanism as we did not detect a direct association of hnRNP K with DNA-bound EBNA2 in gel shift experiments. Our data support the notion that the methylated surface of EBNA2 mimics the surface structure of cellular proteins to interfere with or co-opt their functional properties.

  14. Deletion of small nuclear ribonucleoprotein polypeptide N (SNRPN) in Prader-Willi syndrome detected by fluorescence in situ hybridization: Two sibs with the typical phenotype without a cytogenetic deletion in chromosome 15q

    Energy Technology Data Exchange (ETDEWEB)

    Ishikawa, Tatsuya; Kibe, Tetsuya; Wada, Yoshiro [Nagoya City Univ. Medical School (Japan)

    1996-04-24

    The small nuclear ribonucleoprotein polypeptide N (SNRPN) gene is regarded as one of the candidates for Prader-Willi syndrome (PWS). We describe two sibs with typical PWS presenting deletion of SNRPN detected by fluorescence in situ hybridization (FISH). Neither a cytogenetically detectable 15q12 deletion nor a deletion for the D15S11, D15S10, and GABRB3 cosmid probes were found in either patient. This implies a smaller deletion limited to the PWS critical region. FISH with a SNRPN probe will permit analysis of PWS patients with limited deletions not detectable with other probes. 22 refs., 1 fig.

  15. k -core covers and the core

    NARCIS (Netherlands)

    Sanchez-Rodriguez, E.; Borm, P.; Estevez Fernandez, M.A.; Fiestras-Janeiro, M.G.; Mosquera, M.A.

    2015-01-01

    This paper extends the notion of individual minimal rights for a transferable utility game (TU-game) to coalitional minimal rights using minimal balanced families of a specific type, thus defining a corresponding minimal rights game. It is shown that the core of a TU-game coincides with the core of

  16. k-core covers and the core

    NARCIS (Netherlands)

    Sanchez-Rodriguez, E.; Borm, Peter; Estevez-Fernandez, A.; Fiestras-Janeiro, G.; Mosquera, M.A.

    This paper extends the notion of individual minimal rights for a transferable utility game (TU-game) to coalitional minimal rights using minimal balanced families of a specific type, thus defining a corresponding minimal rights game. It is shown that the core of a TU-game coincides with the core of

  17. Hepatitis delta antigen requires a flexible quasi-double-stranded RNA structure to bind and condense hepatitis delta virus RNA in a ribonucleoprotein complex.

    Science.gov (United States)

    Griffin, Brittany L; Chasovskikh, Sergey; Dritschilo, Anatoly; Casey, John L

    2014-07-01

    The circular genome and antigenome RNAs of hepatitis delta virus (HDV) form characteristic unbranched, quasi-double-stranded RNA secondary structures in which short double-stranded helical segments are interspersed with internal loops and bulges. The ribonucleoprotein complexes (RNPs) formed by these RNAs with the virus-encoded protein hepatitis delta antigen (HDAg) perform essential roles in the viral life cycle, including viral replication and virion formation. Little is understood about the formation and structure of these complexes and how they function in these key processes. Here, the specific RNA features required for HDAg binding and the topology of the complexes formed were investigated. Selective 2'OH acylation analyzed by primer extension (SHAPE) applied to free and HDAg-bound HDV RNAs indicated that the characteristic secondary structure of the RNA is preserved when bound to HDAg. Notably, the analysis indicated that predicted unpaired positions in the RNA remained dynamic in the RNP. Analysis of the in vitro binding activity of RNAs in which internal loops and bulges were mutated and of synthetically designed RNAs demonstrated that the distinctive secondary structure, not the primary RNA sequence, is the major determinant of HDAg RNA binding specificity. Atomic force microscopy analysis of RNPs formed in vitro revealed complexes in which the HDV RNA is substantially condensed by bending or wrapping. Our results support a model in which the internal loops and bulges in HDV RNA contribute flexibility to the quasi-double-stranded structure that allows RNA bending and condensing by HDAg. RNA-protein complexes (RNPs) formed by the hepatitis delta virus RNAs and protein, HDAg, perform critical roles in virus replication. Neither the structures of these RNPs nor the RNA features required to form them have been characterized. HDV RNA is unusual in that it forms an unbranched quasi-double-stranded structure in which short base-paired segments are interspersed

  18. Multi-core Microprocessors

    Indian Academy of Sciences (India)

    programming and computer fundamentals. His current research interests are parallel computing and history of computing. Multi-core microprocessor is an interconnected set of inde- pendent processors called cores integrated on a single sili- con chip. These processing cores communicate and cooperate with one another ...

  19. Core Competence and Education.

    Science.gov (United States)

    Holmes, Gary; Hooper, Nick

    2000-01-01

    Outlines the concept of core competence and applies it to postcompulsory education in the United Kingdom. Adopts an educational perspective that suggests accreditation as the core competence of universities. This economic approach suggests that the market trend toward lifetime learning might best be met by institutions developing a core competence…

  20. Core stability exercise principles.

    Science.gov (United States)

    Akuthota, Venu; Ferreiro, Andrea; Moore, Tamara; Fredericson, Michael

    2008-02-01

    Core stability is essential for proper load balance within the spine, pelvis, and kinetic chain. The so-called core is the group of trunk muscles that surround the spine and abdominal viscera. Abdominal, gluteal, hip girdle, paraspinal, and other muscles work in concert to provide spinal stability. Core stability and its motor control have been shown to be imperative for initiation of functional limb movements, as needed in athletics. Sports medicine practitioners use core strengthening techniques to improve performance and prevent injury. Core strengthening, often called lumbar stabilization, also has been used as a therapeutic exercise treatment regimen for low back pain conditions. This article summarizes the anatomy of the core, the progression of core strengthening, the available evidence for its theoretical construct, and its efficacy in musculoskeletal conditions.

  1. HYDRATE CORE DRILLING TESTS

    Energy Technology Data Exchange (ETDEWEB)

    John H. Cohen; Thomas E. Williams; Ali G. Kadaster; Bill V. Liddell

    2002-11-01

    The ''Methane Hydrate Production from Alaskan Permafrost'' project is a three-year endeavor being conducted by Maurer Technology Inc. (MTI), Noble, and Anadarko Petroleum, in partnership with the U.S. DOE National Energy Technology Laboratory (NETL). The project's goal is to build on previous and ongoing R&D in the area of onshore hydrate deposition. The project team plans to design and implement a program to safely and economically drill, core and produce gas from arctic hydrates. The current work scope includes drilling and coring one well on Anadarko leases in FY 2003 during the winter drilling season. A specially built on-site core analysis laboratory will be used to determine some of the physical characteristics of the hydrates and surrounding rock. Prior to going to the field, the project team designed and conducted a controlled series of coring tests for simulating coring of hydrate formations. A variety of equipment and procedures were tested and modified to develop a practical solution for this special application. This Topical Report summarizes these coring tests. A special facility was designed and installed at MTI's Drilling Research Center (DRC) in Houston and used to conduct coring tests. Equipment and procedures were tested by cutting cores from frozen mixtures of sand and water supported by casing and designed to simulate hydrate formations. Tests were conducted with chilled drilling fluids. Tests showed that frozen core can be washed out and reduced in size by the action of the drilling fluid. Washing of the core by the drilling fluid caused a reduction in core diameter, making core recovery very difficult (if not impossible). One successful solution was to drill the last 6 inches of core dry (without fluid circulation). These tests demonstrated that it will be difficult to capture core when drilling in permafrost or hydrates without implementing certain safeguards. Among the coring tests was a simulated hydrate

  2. Electron cryotomography studies of maturing HIV-1 particles reveal the assembly pathway of the viral core.

    Science.gov (United States)

    Woodward, Cora L; Cheng, Sarah N; Jensen, Grant J

    2015-01-15

    To better characterize the assembly of the HIV-1 core, we have used electron cryotomography (ECT) to image infected cells and the viral particles cryopreserved next to them. We observed progressive stages of virus assembly and egress, including flower-like flat Gag lattice assemblies, hemispherical budding profiles, and virus buds linked to the plasma membrane via a thin membrane neck. The population of budded viral particles contains immature, maturation-intermediate, and mature core morphologies. Structural characteristics of the maturation intermediates suggest that the core assembly pathway involves the formation of a CA sheet that associates with the condensed ribonucleoprotein (RNP) complex. Our analysis also reveals a correlation between RNP localization within the viral particle and the formation of conical cores, suggesting that the RNP helps drive conical core assembly. Our findings support an assembly pathway for the HIV-1 core that begins with a small CA sheet that associates with the RNP to form the core base, followed by polymerization of the CA sheet along one side of the conical core toward the tip, and then closure around the body of the cone. During HIV-1 assembly and release, the Gag polyprotein is organized into a signature hexagonal lattice, termed the immature lattice. To become infectious, the newly budded virus must disassemble the immature lattice by proteolyzing Gag and then reassemble the key proteolytic product, the structural protein p24 (CA), into a distinct, mature hexagonal lattice during a process termed maturation. The mature HIV-1 virus contains a conical capsid that encloses the condensed viral genome at its wide base. Mutations or small molecules that interfere with viral maturation also disrupt viral infectivity. Little is known about the assembly pathway that results in the conical core and genome encapsidation. Here, we have used electron cryotomography to structurally characterize HIV-1 particles that are actively maturing

  3. Sediment Core Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides instrumentation and expertise for physical and geoacoustic characterization of marine sediments.DESCRIPTION: The multisensor core logger measures...

  4. Adaptive core simulation

    Science.gov (United States)

    Abdel-Khalik, Hany Samy

    The work presented in this thesis is a continuation of a master's thesis research project conducted by the author to gain insight into the applicability of inverse methods to developing adaptive simulation capabilities for core physics problems. Use of adaptive simulation is intended to improve the fidelity and robustness of important core attributes predictions such as core power distribution, thermal margins and core reactivity. Adaptive simulation utilizes a selected set of past and current reactor measurements of reactor observables, i.e. in-core instrumentations readings, to adapt the simulation in a meaningful way. A meaningful adaption will result in high fidelity and robust adapted core simulators models. To perform adaption, we propose an inverse theory approach in which the multitudes of input data to core simulators, i.e. reactor physics and thermal-hydraulic data, are to be adjusted to improve agreement with measured observables while keeping core simulators models unadapted. At a first glance, devising such adaption for typical core simulators models would render the approach impractical. This follows, since core simulators are based on very demanding computational models, i.e. based on complex physics models with millions of input data and output observables. This would spawn not only several prohibitive challenges but also numerous disparaging concerns. The challenges include the computational burdens of the sensitivity-type calculations required to construct Jacobian operators for the core simulators models. Also, the computational burdens of the uncertainty-type calculations required to estimate the uncertainty information of core simulators input data presents a demanding challenge. The concerns however are mainly related to the reliability of the adjusted input data. We demonstrate that the power of our proposed approach is mainly driven by taking advantage of this unfavorable situation. Our contribution begins with the realization that to obtain

  5. Core physics experiment of 100% MOX core: MISTRAL

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, T.; Matsu-ura, H.; Ueji, M. [Nuclear Power Engineering Corp., Tokyo (Japan); Cathalau, S.; Cabrillat, J.C.; Chauvin, J.P.; Finck, P.J.; Fougeras, P.; Flamenbaum, G.

    1997-12-31

    An extensive experimental program, MISTRAL, was undertaken in the EOLE critical facility of CEA in order to measure the main core physics parameters of 100% MOX loaded cores of light water reactors. The experimental program comprises four core configurations with high moderator to fuel ratio, including three homogeneous cores and one PWR type mock-up core. This paper presents the experiment of the first homogeneous core of uranium fuel as a reference core of the MOX cores and a part of the experiment of the second core, a 100% MOX homogeneous core. (author)

  6. Can Psychiatric Rehabilitation Be Core to CORE?

    Science.gov (United States)

    Olney, Marjorie F.; Gill, Kenneth J.

    2016-01-01

    Purpose: In this article, we seek to determine whether psychiatric rehabilitation principles and practices have been more fully incorporated into the Council on Rehabilitation Education (CORE) standards, the extent to which they are covered in four rehabilitation counseling "foundations" textbooks, and how they are reflected in the…

  7. Lunar Core and Tides

    Science.gov (United States)

    Williams, J. G.; Boggs, D. H.; Ratcliff, J. T.

    2004-01-01

    Variations in rotation and orientation of the Moon are sensitive to solid-body tidal dissipation, dissipation due to relative motion at the fluid-core/solid-mantle boundary, and tidal Love number k2 [1,2]. There is weaker sensitivity to flattening of the core-mantle boundary (CMB) [2,3,4] and fluid core moment of inertia [1]. Accurate Lunar Laser Ranging (LLR) measurements of the distance from observatories on the Earth to four retroreflector arrays on the Moon are sensitive to lunar rotation and orientation variations and tidal displacements. Past solutions using the LLR data have given results for dissipation due to solid-body tides and fluid core [1] plus Love number [1-5]. Detection of CMB flattening, which in the past has been marginal but improving [3,4,5], now seems significant. Direct detection of the core moment has not yet been achieved.

  8. The t-core of an s-core

    OpenAIRE

    Fayers, Matthew

    2011-01-01

    We consider the $t$-core of an $s$-core partition, when $s$ and $t$ are coprime positive integers. Olsson has shown that the $t$-core of an $s$-core is again an $s$-core, and we examine certain actions of the affine symmetric group on $s$-cores which preserve the $t$-core of an $s$-core. Along the way, we give a new proof of Olsson's result. We also give a new proof of a result of Vandehey, showing that there is a simultaneous $s$- and $t$-core which contains all others.

  9. Dependence of Core and Extended Flux on Core Dominance ...

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... Based on two extragalactic radio source samples, the core dominance parameter is calculated, and the correlations between the core/extended flux density and core dominance parameter are investigated. When the core dominance parameter is lower than unity, it is linearly correlated with the core flux ...

  10. Earth's inner core: Innermost inner core or hemispherical variations?

    NARCIS (Netherlands)

    Lythgoe, K. H.; Deuss, A.; Rudge, J. F.; Neufeld, J. A.

    2014-01-01

    The structure of Earth's deep inner core has important implications for core evolution, since it is thought to be related to the early stages of core formation. Previous studies have suggested that there exists an innermost inner core with distinct anisotropy relative to the rest of the inner core.

  11. Dependence of Core and Extended Flux on Core Dominance ...

    Indian Academy of Sciences (India)

    Abstract. Based on two extragalactic radio source samples, the core dominance parameter is calculated, and the correlations between the core/extended flux density and core dominance parameter are investi- gated. When the core dominance parameter is lower than unity, it is linearly correlated with the core flux density, ...

  12. Korrelasjon mellom core styrke, core stabilitet og utholdende styrke i core

    OpenAIRE

    Berg-Olsen, Andrea Marie; Fugelsøy, Eivor; Maurstad, Ann-Louise

    2010-01-01

    Formålet med studien var å se hvilke korrelasjon det er mellom core styrke, core stabilitet og utholdende styrke i core. Testingen bestod av tre hoveddeler hvor vi testet core styrke, core stabilitet og utholdende styrke i core. Innenfor core styrke og utholdende styrke i core ble tre ulike tester utført. Ved måling av core stabilitet ble det gjennomført kun en test. I core styrke ble isometrisk abdominal fleksjon, isometrisk rygg ekstensjon og isometrisk lateral fleksjon testet. Sit-ups p...

  13. Core stability and bicycling.

    Science.gov (United States)

    Asplund, Chad; Ross, Michael

    2010-01-01

    Bicycling is a popular fitness activity in the United States and around the world. Because of the nature of the bicycling position, the neck and back are at risk for injury. One method to prevent these injuries is to ensure that the body's "core" is strong and stable. A strong and stable core also provides a platform to maximize power transfer, improving performance. Core exercises also may enhance recovery from intense bicycling efforts. Simple stability exercises can improve performance and may prevent injuries in bicyclists.

  14. IGCSE core mathematics

    CERN Document Server

    Wall, Terry

    2013-01-01

    Give your core level students the support and framework they require to get their best grades with this book dedicated to the core level content of the revised syllabus and written specifically to ensure a more appropriate pace. This title has been written for Core content of the revised Cambridge IGCSE Mathematics (0580) syllabus for first teaching from 2013. ? Gives students the practice they require to deepen their understanding through plenty of practice questions. ? Consolidates learning with unique digital resources on the CD, included free with every book. We are working with Cambridge

  15. Core shroud corner joints

    Science.gov (United States)

    Gilmore, Charles B.; Forsyth, David R.

    2013-09-10

    A core shroud is provided, which includes a number of planar members, a number of unitary corners, and a number of subassemblies each comprising a combination of the planar members and the unitary corners. Each unitary corner comprises a unitary extrusion including a first planar portion and a second planar portion disposed perpendicularly with respect to the first planar portion. At least one of the subassemblies comprises a plurality of the unitary corners disposed side-by-side in an alternating opposing relationship. A plurality of the subassemblies can be combined to form a quarter perimeter segment of the core shroud. Four quarter perimeter segments join together to form the core shroud.

  16. INTEGRAL core programme

    Science.gov (United States)

    Gehrels, N.; Schoenfelder, V.; Ubertini, P.; Winkler, C.

    1997-01-01

    The International Gamma Ray Astrophysics Laboratory (INTEGRAL) mission is described with emphasis on the INTEGRAL core program. The progress made in the planning activities for the core program is reported on. The INTEGRAL mission has a nominal lifetime of two years with a five year extension option. The observing time will be divided between the core program (between 30 and 35 percent during the first two years) and general observations. The core program consists of three main elements: the deep survey of the Galactic plane in the central radian of the Galaxy; frequent scans of the Galactic plane in the search for transient sources, and pointed observations of several selected sources. The allocation of the observation time is detailed and the sensitivities of the observations are outlined.

  17. The core helium flash

    Science.gov (United States)

    Cole, P. W.; Deupree, R. G.

    1980-12-01

    The role of convection in the core helium flash is simulated by two-dimensional eddies interacting with the thermonuclear runaway. These eddies are followed by the explicit solution of the two-dimensional conservation laws with a two-dimensional finite difference hydrodynamics code. Thus, no phenomenological theory of convection such as the local mixing length theory is required. The core helium flash is violent, producing a deflagration wave. This differs from the detonation wave (and subsequent disruption of the entire star) produced in previous spherically symmetric violent core helium flashes as the second dimension provides a degree of relief which allows the expansion wave to decouple itself from the burning front. The results predict that a considerable amount of helium in the core will be burned before the horizontal branch is reached and that some envelope mass loss is likely.

  18. Organizing Core Tasks

    DEFF Research Database (Denmark)

    Boll, Karen

    Civil servants conduct the work which makes welfare states functions on an everyday bases: Police men police, school teachers teach, and tax inspectors inspect. Focus in this paper is on the core tasks of tax inspectors. The paper argues that their core task of securing the collection of revenue...... has remained much the same within the last 10 years. However, how the core task has been organized has changed considerable under the influence of various “organizing devices”. The paper focusses on how organizing devices such as risk assessment, output-focus, effect orientation, and treatment...... projects influence the organization of core tasks within the tax administration. The paper shows that the organizational transformations based on the use of these devices have had consequences both for the overall collection of revenue and for the employees’ feeling of “making a difference”. All in all...

  19. Reference: -300CORE [PLACE

    Lifescience Database Archive (English)

    Full Text Available -300CORE Forde BG, Heyworth A, Pywell J, Kreis M Nucleotide sequence of a B1 hordein gene and the identifica...tion of possible upstream regulatory elements in endosperm storage protein genes fr

  20. iPSC Core

    Data.gov (United States)

    Federal Laboratory Consortium — The induced Pluripotent Stem Cells (iPSC) Core was created in 2011 to accelerate stem cell research in the NHLBI by providing investigators consultation, technical...

  1. The Core Knowledge System

    National Research Council Canada - National Science Library

    Strat, Thomas M; Smith, Grahame B

    1987-01-01

    This document contains an in-depth description of the Core Knowledge System (CKS)-an integrative environment for the many functions that must be performed by sensor-based autonomous and semi-autonomous systems...

  2. Double sequence core theorems

    Directory of Open Access Journals (Sweden)

    Richard F. Patterson

    1999-01-01

    Full Text Available In 1900, Pringsheim gave a definition of the convergence of double sequences. In this paper, that notion is extended by presenting definitions for the limit inferior and limit superior of double sequences. Also the core of a double sequence is defined. By using these definitions and the notion of regularity for 4-dimensional matrices, extensions, and variations of the Knopp Core theorem are proved.

  3. MCNP LWR Core Generator

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Noah A. [Los Alamos National Laboratory

    2012-08-14

    The reactor core input generator allows for MCNP input files to be tailored to design specifications and generated in seconds. Full reactor models can now easily be created by specifying a small set of parameters and generating an MCNP input for a full reactor core. Axial zoning of the core will allow for density variation in the fuel and moderator, with pin-by-pin fidelity, so that BWR cores can more accurately be modeled. LWR core work in progress: (1) Reflectivity option for specifying 1/4, 1/2, or full core simulation; (2) Axial zoning for moderator densities that vary with height; (3) Generating multiple types of assemblies for different fuel enrichments; and (4) Parameters for specifying BWR box walls. Fuel pin work in progress: (1) Radial and azimuthal zoning for generating further unique materials in fuel rods; (2) Options for specifying different types of fuel for MOX or multiple burn assemblies; (3) Additional options for replacing fuel rods with burnable poison rods; and (4) Control rod/blade modeling.

  4. Packing in protein cores

    Science.gov (United States)

    Gaines, J. C.; Clark, A. H.; Regan, L.; O'Hern, C. S.

    2017-07-01

    Proteins are biological polymers that underlie all cellular functions. The first high-resolution protein structures were determined by x-ray crystallography in the 1960s. Since then, there has been continued interest in understanding and predicting protein structure and stability. It is well-established that a large contribution to protein stability originates from the sequestration from solvent of hydrophobic residues in the protein core. How are such hydrophobic residues arranged in the core; how can one best model the packing of these residues, and are residues loosely packed with multiple allowed side chain conformations or densely packed with a single allowed side chain conformation? Here we show that to properly model the packing of residues in protein cores it is essential that amino acids are represented by appropriately calibrated atom sizes, and that hydrogen atoms are explicitly included. We show that protein cores possess a packing fraction of φ ≈ 0.56 , which is significantly less than the typically quoted value of 0.74 obtained using the extended atom representation. We also compare the results for the packing of amino acids in protein cores to results obtained for jammed packings from discrete element simulations of spheres, elongated particles, and composite particles with bumpy surfaces. We show that amino acids in protein cores pack as densely as disordered jammed packings of particles with similar values for the aspect ratio and bumpiness as found for amino acids. Knowing the structural properties of protein cores is of both fundamental and practical importance. Practically, it enables the assessment of changes in the structure and stability of proteins arising from amino acid mutations (such as those identified as a result of the massive human genome sequencing efforts) and the design of new folded, stable proteins and protein-protein interactions with tunable specificity and affinity.

  5. Bioinformatics Core Project Management

    Science.gov (United States)

    Vangala, Mahesh; Vincent, James; Driscoll, Heather

    2013-01-01

    Bioinformatics cores that provide fee for service style support encounter a wide variety of projects. The scope of projects varies greatly among investigators. Because of this variety, it is difficult to develop a set of predefined services that fit all project types. While our own core has developed a baseline set of services, we found in practice these often needed significant modification to meet the goals of particular investigator. To overcome this problem we factored common features of all projects and partitioned them into groups: workflow management, data management, user results, and tracking and reporting. We then implemented best practices for each group using commercial and open source software combined with our own management policies. Finally we linked these areas together to produce an overall integrated project management solution that combines workflow management, data management, user results management and reporting capabilities. This system solves the problem of developing well defined services that are trackable and repeatable while simultaneously enabling flexibility that is easily managed. The result improves the effectiveness and efficiency of the bioinformatics core for scientists working within the core, for investigators receiving core support and for external auditors and evaluators.

  6. Inner core structure behind the PKP core phase triplication

    NARCIS (Netherlands)

    Blom, Nienke A.; Deuss, Arwen; Paulssen, Hanneke; Waszek, Lauren

    The structure of the Earth's inner core is not well known between depths of ∼100–200 km beneath the inner core boundary. This is a result of the PKP core phase triplication and the existence of strong precursors to PKP phases, which hinder the measurement of inner core compressional PKIKP waves at

  7. GREEN CORE HOUSE

    Directory of Open Access Journals (Sweden)

    NECULAI Oana

    2017-05-01

    Full Text Available The Green Core House is a construction concept with low environmental impact, having as main central element a greenhouse. The greenhouse has the innovative role to use the biomass energy provided by plants to save energy. Although it is the central piece, the greenhouse is not the most innovative part of the Green Core House, but the whole building ensemble because it integrates many other sustainable systems as "waste purification systems", "transparent photovoltaic panels" or "double skin façades".

  8. Birefringent hollow core fibers

    DEFF Research Database (Denmark)

    Roberts, John

    2007-01-01

    Hollow core photonic crystal fiber (HC-PCF), fabricated according to a nominally non-birefringent design, shows a degree of un-controlled birefringence or polarization mode dispersion far in excess of conventional non polarization maintaining fibers. This can degrade the output pulse in many...... and an increased overlap between the polarization modes at the glass interfaces. The interplay between these effects leads to a wavelength for optimum polarization maintenance, lambda(PM), which is detuned from the wavelength of highest birefringence. By a suitable fiber design involving antiresonance of the core...

  9. CORE COMPONENT POT

    Energy Technology Data Exchange (ETDEWEB)

    MARTIN RL; OMBERG RP

    1975-12-19

    The core component pot is an open top vessel used to hold both new and irradiated core components for storage in the IDS and for holding the components submerged in sodium while being trasported inside CLEM. The top of the CCP is equipped with a grapple lip which is engaged by the hoisting grapples. Heat for maintaining the preheat of new components and dissipation of decay heat of irradiated fuel assemblies is conducted between the wall of the pot and the surrounding environment by thermal radiation and convection.

  10. Maximum stellar iron core mass

    Indian Academy of Sciences (India)

    An analytical method of estimating the mass of a stellar iron core, just prior to core collapse, is described in this paper. The method employed depends, in part, upon an estimate of the true relativistic mass increase experienced by electrons within a highly compressed iron core, just prior to core collapse, and is significantly ...

  11. Inflation targeting and core inflation

    OpenAIRE

    Julie Smith

    2005-01-01

    This paper examines the interaction of core inflation and inflation targeting as a monetary policy regime. Interest in core inflation has grown because of inflation targeting. Core inflation is defined in numerous ways giving rise to many potential measures; this paper defines core inflation as the best forecaster of inflation. A cross-country study finds before the start of inflation targeting, but not after, core inflation differs between non-inflation targeters and inflation targeters. Thr...

  12. NUCLEAR REACTOR CORE DESIGN

    Science.gov (United States)

    Mahlmeister, J.E.; Peck, W.S.; Haberer, W.V.; Williams, A.C.

    1960-03-22

    An improved core design for a sodium-cooled, graphitemoderated nuclear reactor is described. The improved reactor core comprises a number of blocks of moderator material, each block being in the shape of a regular prism. A number of channels, extending the length of each block, are disposed around the periphery. When several blocks are placed in contact to form the reactor core, the channels in adjacent blocks correspond with each other to form closed conduits extending the length of the core. Fuel element clusters are disposed in these closed conduits, and liquid coolant is forced through the annulus between the fuel cluster and the inner surface of the conduit. In a preferred embodiment of the invention, the moderator blocks are in the form of hexagonal prisms with longitudinal channels cut into the corners of the hexagon. The main advantage of an "edge-loaded" moderator block is that fewer thermal neutrons are absorbed by the moderator cladding, as compared with a conventional centrally loaded moderator block.

  13. Schumpeter's core works revisited

    DEFF Research Database (Denmark)

    Andersen, Esben Sloth

    2012-01-01

    This paper organises Schumpeter’s core books in three groups: the programmatic duology,the evolutionaryeconomic duology,and the socioeconomic synthesis. By analysing these groups and their interconnections from the viewpoint of modern evolutionaryeconomics,the paper summarises resolved problems...

  14. Core Obstetrics and Gynaecology*

    African Journals Online (AJOL)

    Core Obstetrics and Gynaecology*. By J. T. Nel. Pp xvii + 992. Illustrated. Durban: Butterworths. 1995. ISBN 0-409-10134-6. For some years now, I have lamented the absence of a good, home-grown, comprehensive, student-centred textbook of obstetrics and gynaecology designed specifically for South African needs.

  15. Adult educators' core competences

    DEFF Research Database (Denmark)

    Wahlgren, Bjarne

    2016-01-01

    environment as well as the kind of adult education concerned (e.g. basic education, work-related education etc.). However, it seems that it is possible to identify certain competence requirements which transcend national, cultural and functional boundaries. This research note summarises these common or “core...

  16. The core and cosmopolitans

    DEFF Research Database (Denmark)

    Dahlander, Linus; Frederiksen, Lars

    2012-01-01

    Users often interact and help each other solve problems in communities, but few scholars have explored how these relationships provide opportunities to innovate. We analyze the extent to which people positioned within the core of a community as well as people that are cosmopolitans positioned...

  17. Looking for Core Values

    Science.gov (United States)

    Carter, Margie

    2010-01-01

    People who view themselves as leaders, not just managers or teachers, are innovators who focus on clarifying core values and aligning all aspects of the organization with these values to grow their vision. A vision for an organization can't be just one person's idea. Visions grow by involving people in activities that help them name and create…

  18. Some Core Contested Concepts

    Science.gov (United States)

    Chomsky, Noam

    2015-01-01

    Core concepts of language are highly contested. In some cases this is legitimate: real empirical and conceptual issues arise. In other cases, it seems that controversies are based on misunderstanding. A number of crucial cases are reviewed, and an approach to language is outlined that appears to have strong conceptual and empirical motivation, and…

  19. Modeling Core Collapse Supernovae

    Science.gov (United States)

    Mezzacappa, Anthony

    2017-01-01

    Core collapse supernovae, or the death throes of massive stars, are general relativistic, neutrino-magneto-hydrodynamic events. The core collapse supernova mechanism is still not in hand, though key components have been illuminated, and the potential for multiple mechanisms for different progenitors exists. Core collapse supernovae are the single most important source of elements in the Universe, and serve other critical roles in galactic chemical and thermal evolution, the birth of neutron stars, pulsars, and stellar mass black holes, the production of a subclass of gamma-ray bursts, and as potential cosmic laboratories for fundamental nuclear and particle physics. Given this, the so called ``supernova problem'' is one of the most important unsolved problems in astrophysics. It has been fifty years since the first numerical simulations of core collapse supernovae were performed. Progress in the past decade, and especially within the past five years, has been exponential, yet much work remains. Spherically symmetric simulations over nearly four decades laid the foundation for this progress. Two-dimensional modeling that assumes axial symmetry is maturing. And three-dimensional modeling, while in its infancy, has begun in earnest. I will present some of the recent work from the ``Oak Ridge'' group, and will discuss this work in the context of the broader work by other researchers in the field. I will then point to future requirements and challenges. Connections with other experimental, observational, and theoretical efforts will be discussed, as well.

  20. Core calculations of JMTR

    Energy Technology Data Exchange (ETDEWEB)

    Nagao, Yoshiharu [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment

    1998-03-01

    In material testing reactors like the JMTR (Japan Material Testing Reactor) of 50 MW in Japan Atomic Energy Research Institute, the neutron flux and neutron energy spectra of irradiated samples show complex distributions. It is necessary to assess the neutron flux and neutron energy spectra of an irradiation field by carrying out the nuclear calculation of the core for every operation cycle. In order to advance core calculation, in the JMTR, the application of MCNP to the assessment of core reactivity and neutron flux and spectra has been investigated. In this study, in order to reduce the time for calculation and variance, the comparison of the results of the calculations by the use of K code and fixed source and the use of Weight Window were investigated. As to the calculation method, the modeling of the total JMTR core, the conditions for calculation and the adopted variance reduction technique are explained. The results of calculation are shown. Significant difference was not observed in the results of neutron flux calculations according to the difference of the modeling of fuel region in the calculations by K code and fixed source. The method of assessing the results of neutron flux calculation is described. (K.I.)

  1. The Uncommon Core

    Science.gov (United States)

    Ohler, Jason

    2013-01-01

    This author contends that the United States neglects creativity in its education system. To see this, he states, one may look at the Common Core State Standards. If one searches the English Language Arts and Literacy standards for the words "creative," "innovative," and "original"--and any associated terms, one will…

  2. EJC core component MLN51 interacts with eIF3 and activates translation.

    Science.gov (United States)

    Chazal, Pierre-Etienne; Daguenet, Elisabeth; Wendling, Corinne; Ulryck, Nathalie; Tomasetto, Catherine; Sargueil, Bruno; Le Hir, Hervé

    2013-04-09

    The multiprotein exon junction complex (EJC), deposited by the splicing machinery, is an important constituent of messenger ribonucleoprotein particles because it participates to numerous steps of the mRNA lifecycle from splicing to surveillance via nonsense-mediated mRNA decay pathway. By an unknown mechanism, the EJC also stimulates translation efficiency of newly synthesized mRNAs. Here, we show that among the four EJC core components, the RNA-binding protein metastatic lymph node 51 (MLN51) is a translation enhancer. Overexpression of MLN51 preferentially increased the translation of intron-containing reporters via the EJC, whereas silencing MLN51 decreased translation. In addition, modulation of the MLN51 level in cell-free translational extracts confirmed its direct role in protein synthesis. Immunoprecipitations indicated that MLN51 associates with translation-initiating factors and ribosomal subunits, and in vitro binding assays revealed that MLN51, alone or as part of the EJC, interacts directly with the pivotal eukaryotic translation initiation factor eIF3. Taken together, our data define MLN51 as a translation activator linking the EJC and the translation machinery.

  3. Mutations in SNRPB, encoding components of the core splicing machinery, cause cerebro-costo-mandibular syndrome.

    Science.gov (United States)

    Bacrot, Séverine; Doyard, Mathilde; Huber, Céline; Alibeu, Olivier; Feldhahn, Niklas; Lehalle, Daphné; Lacombe, Didier; Marlin, Sandrine; Nitschke, Patrick; Petit, Florence; Vazquez, Marie-Paule; Munnich, Arnold; Cormier-Daire, Valérie

    2015-02-01

    Cerebro-costo-mandibular syndrome (CCMS) is a developmental disorder characterized by the association of Pierre Robin sequence and posterior rib defects. Exome sequencing and Sanger sequencing in five unrelated CCMS patients revealed five heterozygous variants in the small nuclear ribonucleoprotein polypeptides B and B1 (SNRPB) gene. This gene includes three transcripts, namely transcripts 1 and 2, encoding components of the core spliceosomal machinery (SmB' and SmB) and transcript 3 undergoing nonsense-mediated mRNA decay. All variants were located in the premature termination codon (PTC)-introducing alternative exon of transcript 3. Quantitative RT-PCR analysis revealed a significant increase in transcript 3 levels in leukocytes of CCMS individuals compared to controls. We conclude that CCMS is due to heterozygous mutations in SNRPB, enhancing inclusion of a SNRPB PTC-introducing alternative exon, and show that this developmental disease is caused by defects in the splicing machinery. Our finding confirms the report of SNRPB mutations in CCMS patients by Lynch et al. (2014) and further extends the clinical and molecular observations. © 2014 WILEY PERIODICALS, INC.

  4. Measuring core stability.

    Science.gov (United States)

    Liemohn, Wendell P; Baumgartner, Ted A; Gagnon, Laura H

    2005-08-01

    In this study, a 4-item battery of core stability (CS) tests modeled on core stabilization activities used in training and rehabilitation research was developed, and a measurement schedule was established to maximize internal consistency and stability reliabilities. Specifically, we found that 4 test administrations on each of 4 days produced intraclass correlation coefficients that in most instances exceeded 0.90 and stability reliability coefficients on the third and fourth days of testing that exceeded 0.90 for 2 of the tests and 0.80 for the other 2. Thus, it is recommended that in future research, examiners administer the battery for at least 3 days and consider the data collected on day 3 as the best estimate of participant CS.

  5. Core Outlet Temperature Study

    Energy Technology Data Exchange (ETDEWEB)

    Moisseytsev, A. [Argonne National Laboratory (ANL), Argonne, IL (United States); Hoffman, E. [Argonne National Laboratory (ANL), Argonne, IL (United States); Majumdar, S. [Argonne National Laboratory (ANL), Argonne, IL (United States)

    2008-07-28

    It is a known fact that the power conversion plant efficiency increases with elevation of the heat addition temperature. The higher efficiency means better utilization of the available resources such that higher output in terms of electricity production can be achieved for the same size and power of the reactor core or, alternatively, a lower power core could be used to produce the same electrical output. Since any nuclear power plant, such as the Advanced Burner Reactor, is ultimately built to produce electricity, a higher electrical output is always desirable. However, the benefits of the higher efficiency and electricity production usually come at a price. Both the benefits and the disadvantages of higher reactor outlet temperatures are analyzed in this work.

  6. Ice Cores of the National Ice Core Laboratory

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The U.S. National Ice Core Laboratory (NICL) is a facility for storing, curating, and studying ice cores recovered from the polar regions of the world. It provides...

  7. Core Exercises: Why You Should Strengthen Your Core Muscles

    Science.gov (United States)

    ... neglected. Still, it pays to get your core muscles — the muscles around your trunk and pelvis — in better shape. ... to find out why. Core exercises train the muscles in your pelvis, lower back, hips and abdomen ...

  8. USGS Core Research Center (CRC) Collection of Core

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Core Research Center (CRC) was established in 1974 by the U.S. Geological Survey (USGS) to preserve valuable rock cores for use by scientists and educators from...

  9. Leadership Core Competencies

    Science.gov (United States)

    2008-03-15

    different approaches led to a very similar understanding of what is required to develop leaders and achieve mission success. LEADERSHIP CORE... Leadership , the first principle, Know yourself and seek self-improvement performs the same function. Similar to the other services, Navy leaders evaluate... leadership styles. Like managers of today, those of tomorrow will also need to do more with less. They will have increased responsibilities and will

  10. Optimizing performance by improving core stability and core strength.

    Science.gov (United States)

    Hibbs, Angela E; Thompson, Kevin G; French, Duncan; Wrigley, Allan; Spears, Iain

    2008-01-01

    Core stability and core strength have been subject to research since the early 1980s. Research has highlighted benefits of training these processes for people with back pain and for carrying out everyday activities. However, less research has been performed on the benefits of core training for elite athletes and how this training should be carried out to optimize sporting performance. Many elite athletes undertake core stability and core strength training as part of their training programme, despite contradictory findings and conclusions as to their efficacy. This is mainly due to the lack of a gold standard method for measuring core stability and strength when performing everyday tasks and sporting movements. A further confounding factor is that because of the differing demands on the core musculature during everyday activities (low load, slow movements) and sporting activities (high load, resisted, dynamic movements), research performed in the rehabilitation sector cannot be applied to the sporting environment and, subsequently, data regarding core training programmes and their effectiveness on sporting performance are lacking. There are many articles in the literature that promote core training programmes and exercises for performance enhancement without providing a strong scientific rationale of their effectiveness, especially in the sporting sector. In the rehabilitation sector, improvements in lower back injuries have been reported by improving core stability. Few studies have observed any performance enhancement in sporting activities despite observing improvements in core stability and core strength following a core training programme. A clearer understanding of the roles that specific muscles have during core stability and core strength exercises would enable more functional training programmes to be implemented, which may result in a more effective transfer of these skills to actual sporting activities.

  11. Hollow-Core Fiber Lamp

    Science.gov (United States)

    Yi, Lin (Inventor); Tjoelker, Robert L. (Inventor); Burt, Eric A. (Inventor); Huang, Shouhua (Inventor)

    2016-01-01

    Hollow-core capillary discharge lamps on the millimeter or sub-millimeter scale are provided. The hollow-core capillary discharge lamps achieve an increased light intensity ratio between 194 millimeters (useful) and 254 millimeters (useless) light than conventional lamps. The capillary discharge lamps may include a cone to increase light output. Hollow-core photonic crystal fiber (HCPCF) may also be used.

  12. On core stability and extendability

    OpenAIRE

    Shellshear, Evan

    2011-01-01

    This paper investigates conditions under which the core of a TU cooperative game is stable. In particular the author extends the idea of extendability to find new conditions under which the core is stable. It is also shown that these new conditions are not necessary for core stability.

  13. Maximum stellar iron core mass

    Indian Academy of Sciences (India)

    Abstract. An analytical method of estimating the mass of a stellar iron core, just prior to core collapse, is .... approximately as an ideal gas, the mean kinetic energies of the free electrons and atomic nuclei will be equal. .... whose density varies from a maximum at the core's center to a minimum at its 'surface'. The dimensional ...

  14. Dual-core Itanium Processor

    CERN Multimedia

    2006-01-01

    Intel’s first dual-core Itanium processor, code-named "Montecito" is a major release of Intel's Itanium 2 Processor Family, which implements the Intel Itanium architecture on a dual-core processor with two cores per die (integrated circuit). Itanium 2 is much more powerful than its predecessor. It has lower power consumption and thermal dissipation.

  15. Heterogeneous nuclear ribonucleoprotein (HnRNP) K genome-wide binding survey reveals its role in regulating 3'-end RNA processing and transcription termination at the early growth response 1 (EGR1) gene through XRN2 exonuclease.

    Science.gov (United States)

    Mikula, Michal; Bomsztyk, Karol; Goryca, Krzysztof; Chojnowski, Krzysztof; Ostrowski, Jerzy

    2013-08-23

    The heterogeneous nuclear ribonucleoprotein K (hnRNPK) is a nucleic acid-binding protein that acts as a docking platform integrating signal transduction pathways to nucleic acid-related processes. Given that hnRNPK could be involved in other steps that compose gene expression the definition of its genome-wide occupancy is important to better understand its role in transcription and co-transcriptional processes. Here, we used chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) to analyze the genome-wide hnRNPK-DNA interaction in colon cancer cell line HCT116. 9.1/3.6 and 7.0/3.4 million tags were sequenced/mapped, then 1809 and 642 hnRNPK binding sites were detected in quiescent and 30-min serum-stimulated cells, respectively. The inspection of sequencing tracks revealed inducible hnRNPK recruitment along a number of immediate early gene loci, including EGR1 and ZFP36, with the highest densities present at the transcription termination sites. Strikingly, hnRNPK knockdown with siRNA resulted in increased pre-RNA levels transcribed downstream of the EGR1 polyadenylation (A) site suggesting altered 3'-end pre-RNA degradation. Further ChIP survey of hnRNPK knockdown uncovered decreased recruitment of the 5'-3' exonuclease XRN2 along EGR1 and downstream of the poly(A) signal without altering RNA polymerase II density at these sites. Immunoprecipitation of hnRNPK and XRN2 from intact and RNase A-treated nuclear extracts followed by shotgun mass spectrometry revealed the presence of hnRNPK and XRN2 in the same complexes along with other spliceosome-related proteins. Our data suggest that hnRNPK may play a role in recruitment of XRN2 to gene loci thus regulating coupling 3'-end pre-mRNA processing to transcription termination.

  16. Full MOX core for ABWR

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Yuki; Yoshioka, Ritsuo; Nagano, Mamoru [Toshiba Corp., Kawasaki, Kanagawa (Japan)

    1996-08-01

    The Japan Atomic Energy Commission has announced the construction plan for an advanced boiling-water reactor (ABWR) with a full MOX (mixed oxide) core instead of ATR. Increased MOX fuel utilization will result in greater savings of uranium ore. A full MOX core for a power plant requires flexibility in MOX fuel utilization, steadiness, and economical operation. We have proposed the optimum full MOX core design for an ABWR based on the MOX fuel and core technologies that we have developed over a period of many years, as well as our considerable experience in uranium fuel and cores. Our full MOX core design for an ABWR has good core characteristics and safety performance with no change in the basic design specifications of the current ABWR. (author)

  17. NEUTRONIC REACTOR CORE INSTRUMENT

    Science.gov (United States)

    Mims, L.S.

    1961-08-22

    A multi-purpose instrument for measuring neutron flux, coolant flow rate, and coolant temperature in a nuclear reactor is described. The device consists essentially of a hollow thimble containing a heat conducting element protruding from the inner wall, the element containing on its innermost end an amount of fissionsble materinl to function as a heat source when subjected to neutron flux irradiation. Thermocouple type temperature sensing means are placed on the heat conducting element adjacent the fissionable material and at a point spaced therefrom, and at a point on the thimble which is in contact with the coolant fluid. The temperature differentials measured between the thermocouples are determinative of the neutron flux, coolant flow, and temperature being measured. The device may be utilized as a probe or may be incorporated in a reactor core. (AE C)

  18. Full MOX core in BWR

    Energy Technology Data Exchange (ETDEWEB)

    Aoyama, Motoo [Power and Industrial Systems R and D Laboratory, Hitachi Ltd., Hitachi, Ibaraki (Japan)

    1999-12-01

    Studies on the core design, the fuel rod thermal-mechanical design and the safety evaluation have been summarized for the Full MOX-ABWR, loaded with MOX fuels up to 100% of the core. Fuel bundle configuration for MOX fuels is identical to the STEP II fuel design and the discharge burnup is about 33 GWd/t. Core performance evaluations and fuel rod thermal-mechanical design analyses have been performed, and it has been confirmed that the design criteria are satisfied with enough margin like the UO{sub 2} fuel loaded core. Safety analyses on transients and accidents have also been performed by considering the MOX fuel and core characteristics adequately through selecting appropriate input data for each safety analysis. All safety criteria are satisfied like the UO{sub 2} core. (author)

  19. Wire core reactor for NTP

    Science.gov (United States)

    Harty, R. B.

    1991-01-01

    The development of the wire core system for Nuclear Thermal Propulsion (NTP) that took place from 1963 to 1965 is discussed. A wire core consists of a fuel wire with spacer wires. It's an annular flow core having a central control rod. There are actually four of these, with beryllium solid reflectors on both ends and all the way around. Much of the information on the concept is given in viewgraph form. Viewgraphs are presented on design details of the wire core, the engine design, engine weight vs. thrust, a technique used to fabricate the wire fuel element, and axial temperature distribution.

  20. Biochemistry Instrumentation Core Technology Center

    Data.gov (United States)

    Federal Laboratory Consortium — The UCLA-DOE Biochemistry Instrumentation Core Facility provides the UCLA biochemistry community with easy access to sophisticated instrumentation for a wide variety...

  1. Characterizing the Core via K-Core Covers

    NARCIS (Netherlands)

    Sanchez, S.M.; Borm, P.E.M.; Estevez, A.

    2013-01-01

    This paper extends the notion of individual minimal rights for a transferable utility game (TU-game) to coalitional minimal rights using minimal balanced families of a specific type, thus defining a corresponding minimal rights game. It is shown that the core of a TU-game coincides with the core of

  2. Global Core Plasma Model

    Science.gov (United States)

    Gallagher, Dennis L.; Craven, Paul D.; Comfort, Richard H.

    1999-01-01

    Over 40 years of ground and spacecraft plasmaspheric measurements have resulted in many statistical descriptions of plasmaspheric properties. In some cases, these properties have been represented as analytical descriptions that are valid for specific regions or conditions. For the most part, what has not been done is to extend regional empirical descriptions or models to the plasmasphere as a whole. In contrast, many related investigations depend on the use of representative plasmaspheric conditions throughout the inner magnetosphere. Wave propagation, involving the transport of energy through the magnetosphere, is strongly affected by thermal plasma density and its composition. Ring current collisional and wave particle losses also strongly depend on these quantities. Plasmaspheric also plays a secondary role in influencing radio signals from the Global Positioning System satellites. The Global Core Plasma Model (GCPM) is an attempt to assimilate previous empirical evidence and regional models for plasmaspheric density into a continuous, smooth model of thermal plasma density in the inner magnetosphere. In that spirit, the International Reference Ionosphere is currently used to complete the low altitude description of density and composition in the model. The models and measurements on which the GCPM is currently based and its relationship to IRI will be discussed.

  3. Adult educators' core competences

    Science.gov (United States)

    Wahlgren, Bjarne

    2016-06-01

    Which competences do professional adult educators need? This research note discusses the topic from a comparative perspective, finding that adult educators' required competences are wide-ranging, heterogeneous and complex. They are subject to context in terms of national and cultural environment as well as the kind of adult education concerned (e.g. basic education, work-related education etc.). However, it seems that it is possible to identify certain competence requirements which transcend national, cultural and functional boundaries. This research note summarises these common or "core" requirements, organising them into four thematic subcategories: (1) communicating subject knowledge; (2) taking students' prior learning into account; (3) supporting a learning environment; and (4) the adult educator's reflection on his or her own performance. At the end of his analysis of different competence profiles, the author notes that adult educators' ability to train adult learners in a way which then enables them to apply and use what they have learned in practice (thus performing knowledge transfer) still seems to be overlooked.

  4. Espaço de cores

    OpenAIRE

    SANTANA, Claudia Feitosa; OIWA, Nestor Norio; COSTA, Marcelo Fernandes da; TIEDEMANN, Klaus Bruno; Silveira, Luiz Carlos de Lima; VENTURA, Dora Selma Fix

    2006-01-01

    O artigo apresenta definições para os termos espaço de cores e sistemas de cores; classifica, de acordo com David Brainard (2003), os sistemas de cores em dois grupos: aparência de cores e diferenças de cores. Dentre os diversos sistemas de cores existentes, o artigo descreve dois deles: o sistema de cores Munsell &– um dos mais utilizados entre os sistemas de aparência de cores &– e a descrição do sistema de cores CIE 1931 &– um dos mais utilizados dentre os sistemas de diferença de cores. F...

  5. The INTEGRAL Core Observing Programme

    DEFF Research Database (Denmark)

    Winkler, C.; Gehrels, N.; Lund, Niels

    1999-01-01

    The Core Programme of the INTEGRAL mission is defined as the portion of the scientific programme covering the guaranteed time observations for the INTEGRAL Science Working Team. This paper describes the current status of the Core Programme preparations and summarizes the key elements...... of the observing programme....

  6. Complicated Politics to the Core

    Science.gov (United States)

    McGuinn, Patrick

    2015-01-01

    People dislike the Common Core for several different reasons, and so it is important to disaggregate the sources of opposition and to assess and then to dispel some of the myths that have built up around it. It also is important to understand the unusual political alliances that have emerged in opposition to Common Core implementation and how they…

  7. Toward full MOX core design

    Energy Technology Data Exchange (ETDEWEB)

    Rouviere, G.; Guillet, J.L. [Cogema BCR/DSDP, 78 - Saint Quentin en Yvelines (France); Bruna, G.B.; Pelet, J. [FRAMATOME, 92 - Paris-La-Defense (France)

    1999-07-01

    This paper presents a selection of the main preliminary results of a study program sponsored by COGEMA and currently carried out by FRAMATOME. The objective of this study is to investigate the feasibility of full MOX core loading in a French 1300 MWe PWR, a recent and widespread standard nuclear power plant. The investigation includes core nuclear design, thermal hydraulic and systems aspects. (authors)

  8. Winning Cores in Parity Games

    DEFF Research Database (Denmark)

    Vester, Steen

    2016-01-01

    in their own right. In particular, we show that the winning core and the winning region for a player in a parity game are equivalently empty. Moreover, the winning core contains all fatal attractors but is not necessarily a dominion itself. Experimental results are very positive both with respect to quality...

  9. Molecular composition of IMP1 ribonucleoprotein granules

    DEFF Research Database (Denmark)

    Jønson, Lars; Vikesaa, Jonas; Krogh, Anders

    2007-01-01

    , and in motile cells IMP-containing granules are dispersed around the nucleus and in cellular protrusions. We isolated the IMP1-containing RNP granules and found that they represent a unique RNP entity distinct from neuronal hStaufen and/or fragile X mental retardation protein granules, processing bodies...

  10. Ribonucleoprotein purification and characterization using RNA Mango.

    Science.gov (United States)

    Panchapakesan, Shanker Shyam S; Ferguson, Matthew L; Hayden, Eric J; Chen, Xin; Hoskins, Aaron A; Unrau, Peter J

    2017-10-01

    The characterization of RNA-protein complexes (RNPs) is a difficult but increasingly important problem in modern biology. By combining the compact RNA Mango aptamer with a fluorogenic thiazole orange desthiobiotin (TO1-Dtb or TO3-Dtb) ligand, we have created an RNA tagging system that simplifies the purification and subsequent characterization of endogenous RNPs. Mango-tagged RNP complexes can be immobilized on a streptavidin solid support and recovered in their native state by the addition of free biotin. Furthermore, Mango-based RNP purification can be adapted to different scales of RNP isolation ranging from pull-down assays to the isolation of large amounts of biochemically defined cellular RNPs. We have incorporated the Mango aptamer into the S. cerevisiae U1 small nuclear RNA (snRNA), shown that the Mango-snRNA is functional in cells, and used the aptamer to pull down a U1 snRNA-associated protein. To demonstrate large-scale isolation of RNPs, we purified and characterized bacterial RNA polymerase holoenzyme (HE) in complex with a Mango-containing 6S RNA. We were able to use the combination of a red-shifted TO3-Dtb ligand and eGFP-tagged HE to follow the binding and release of the 6S RNA by two-color native gel analysis as well as by single-molecule fluorescence cross-correlation spectroscopy. Together these experiments demonstrate how the Mango aptamer in conjunction with simple derivatives of its flurophore ligands enables the purification and characterization of endogenous cellular RNPs in vitro. © 2017 Panchapakesan et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  11. Anisotropic charged core envelope star

    Science.gov (United States)

    Mafa Takisa, P.; Maharaj, S. D.

    2016-08-01

    We study a charged compact object with anisotropic pressures in a core envelope setting. The equation of state is quadratic in the core and linear in the envelope. There is smooth matching between the three regions: the core, envelope and the Reissner-Nordström exterior. We show that the presence of the electric field affects the masses, radii and compactification factors of stellar objects with values which are in agreement with previous studies. We investigate in particular the effect of electric field on the physical features of the pulsar PSR J1614-2230 in the core envelope model. The gravitational potentials and the matter variables are well behaved within the stellar object. We demonstrate that the radius of the core and the envelope can vary by changing the parameters in the speed of sound.

  12. Waves in the core and mechanical core-mantle interactions

    DEFF Research Database (Denmark)

    Jault, D.; Finlay, Chris

    2015-01-01

    This Chapter focuses on time-dependent uid motions in the core interior, which can beconstrained by observations of the Earth's magnetic eld, on timescales which are shortcompared to the magnetic diusion time. This dynamics is strongly inuenced by the Earth's rapid rotation, which rigidies...... the motions in the direction parallel to the Earth'srotation axis. This property accounts for the signicance of the core-mantle topography.In addition, the stiening of the uid in the direction parallel to the rotation axis gives riseto a magnetic diusion layer attached to the core-mantle boundary, which would...

  13. Epistemology and ontology in core ontologies: FOLaw and LRI-Core, two core ontologies for law

    NARCIS (Netherlands)

    Breukers, J.A.P.J.; Hoekstra, R.J.

    2004-01-01

    For more than a decade constructing ontologies for legal domains, we, at the Leibniz Center for Law, felt really the need to develop a core ontology for law that would enable us to re-use the common denominator of the various legal domains. In this paper we present two core ontologies for law. The

  14. ICF Core Sets for stroke.

    Science.gov (United States)

    Geyh, Szilvia; Cieza, Alarcos; Schouten, Jan; Dickson, Hugh; Frommelt, Peter; Omar, Zaliha; Kostanjsek, Nenad; Ring, Haim; Stucki, Gerold

    2004-07-01

    To report on the results of the consensus process integrating evidence from preliminary studies to develop the first version of the Comprehensive ICF Core Set and the Brief ICF Core Set for stroke. A formal decision-making and consensus process integrating evidence gathered from preliminary studies was followed. Preliminary studies included a Delphi exercise, a systematic review, and an empirical data collection. After training in the ICF and based on these preliminary studies relevant ICF categories were identified in a formal consensus process by international experts from different backgrounds. The preliminary studies identified a set of 448 ICF categories at the second, third and fourth ICF levels with 193 categories on body functions, 26 on body structures, 165 on activities and participation, and 64 on environmental factors. Thirty-nine experts from 12 different countries attended the consensus conference on stroke. Altogether 130 second-level categories were included in the Comprehensive ICF Core Set with 41 categories from the component body functions, 5 from body structures, 51 from activities and participation, and 33 from environmental factors. The Brief ICF Core Set included a total of 18 second-level categories (6 on body functions, 2 on body structures, 7 on activities and participation, and 3 on environmental factors). A formal consensus process integrating evidence and expert opinion based on the ICF framework and classification led to the definition of ICF Core Sets for stroke. Both the Comprehensive ICF Core Set and the Brief ICF Core Set were defined.

  15. Discovery of the Earth's core

    Science.gov (United States)

    Brush, Stephen G.

    1980-09-01

    In 1896 when Emil Wiechert proposed his model of the Earth with an iron core and stony shell, scientists generally believed that the entire earth was a solid as rigid as steel. R. D. Oldham's identification of P and S waves in seismological records allowed him to detect a discontinuity corresponding to a boundary between core and shell (mantle) in 1906, and Beno Gutenberg established the depth of this boundary as 2900 km. But failure to detect propagation of S waves through the core was not sufficient evidence to persuade seismologists that it is fluid (contrary to modern textbook statements). Not until 1926 did Harold Jeffreys refute the arguments for solidity and establish that the core is liquid. In 1936 Inge Lehmann discovered the small inner core. K. E. Bullen argued, on the basis of plausible assumptions about compressibility and density, that the inner core is solid. Attempts to find seismic signals that have passed through the inner core as S waves have so far failed (with one possible exception), but analysis of free oscillations provided fairly convincing evidence for its solidity.

  16. Core physics analysis of 100% MOX Core in IRIS

    Energy Technology Data Exchange (ETDEWEB)

    Franceschini, F.; Petrovic, B. [Westinghouse Electric Company LLC, Science and Technology Dept., 1344 Beulah Road, Pittsburgh, PA 15235 (United States)

    2006-07-01

    International Reactor Innovative and Secure (IRIS) is an advanced small-to-medium-size (1000 MWt) Pressurized Water Reactor (PWR), targeting deployment around 2015. Its reference core design is based on the current Westinghouse UO{sub 2} fuel with less than 5% {sup 235}U, and the analysis has been previously completed confirming good performance. The full MOX fuel core is currently under evaluation as one of the alternatives for the second wave of IRIS reactors. A full 3-D neutronic analysis has been performed to examine main core performance parameters, such as critical boron concentration, peaking factors, discharge burnup, etc. The enhanced moderation of the IRIS fuel lattice facilitates MOX core design, and all the obtained results are within the requirements, confirming viability of this option from the reactor physics standpoint. (authors)

  17. European core curriculum in neurorehabilitation

    NARCIS (Netherlands)

    Sandrini, G.; Binder, H.; Homberg, V.; Saltuari, L.; Tarkka, I.; Smania, N.; Corradini, C.; Giustini, A.; Katterer, C.; Picari, L.; Diserens, K.; Koenig, E.; Geurts, A.C.; Anghelescu, A.; Opara, J.; Tonin, P.; Kwakkel, G.; Golyk, V.; Onose, G.; Perennou, D.; Picelli, A.

    2017-01-01

    To date, medical education lacks Europe-wide standards on neurorehabilitation. To address this, the European Federation of NeuroRehabilitation Societies (EFNR) here proposes a postgraduate neurorehabilitation training scheme. In particular, the European medical core curriculum in neurorehabilitation

  18. Viral Evolution Core | FNLCR Staging

    Science.gov (United States)

    Brandon F. Keele, Ph.D. PI/Senior Principal Investigator, Retroviral Evolution Section Head, Viral Evolution Core Leidos Biomedical Research, Inc. Frederick National Laboratory for Cancer Research Frederick, MD 21702-1201 Tel: 301-846-173

  19. Nanoporous polymer liquid core waveguides

    DEFF Research Database (Denmark)

    Gopalakrishnan, Nimi; Christiansen, Mads Brøkner; Ndoni, Sokol

    2010-01-01

    We demonstrate liquid core waveguides defined by UV to enable selective water infiltration in nanoporous polymers, creating an effective refractive index shift Δn=0.13. The mode confinement and propagation loss in these waveguides are presented.......We demonstrate liquid core waveguides defined by UV to enable selective water infiltration in nanoporous polymers, creating an effective refractive index shift Δn=0.13. The mode confinement and propagation loss in these waveguides are presented....

  20. Core Benefits of Network Participation

    OpenAIRE

    Kheiri Pileh Roud, Ensieh

    2015-01-01

    This study deals with the core benefits of network participation from the maritime companies’ perspective. It mainly focuses on the area of innovation, network qualities and absorptive capacities. A single case study has been conducted to address two research questions; 1) what are the core benefits of network participation for a maritime company? 2) Which qualities of network events influence the benefits for the participants? The main findings show that, the networks are valuable communi...

  1. Core break-off mechanism

    Science.gov (United States)

    Myrick, Thomas M. (Inventor)

    2003-01-01

    A mechanism for breaking off and retaining a core sample of a drill drilled into a ground substrate has an outer drill tube and an inner core break-off tube sleeved inside the drill tube. The break-off tube breaks off and retains the core sample by a varying geometric relationship of inner and outer diameters with the drill tube. The inside diameter (ID) of the drill tube is offset by a given amount with respect to its outer diameter (OD). Similarly, the outside diameter (OD) of the break-off tube is offset by the same amount with respect to its inner diameter (ID). When the break-off tube and drill tube are in one rotational alignment, the two offsets cancel each other such that the drill can operate the two tubes together in alignment with the drill axis. When the tubes are rotated 180 degrees to another positional alignment, the two offsets add together causing the core sample in the break-off tube to be displaced from the drill axis and applying shear forces to break off the core sample.

  2. Viscosity of Earth's Outer Core

    CERN Document Server

    Smylie, D E

    2007-01-01

    A viscosity profile across the entire fluid outer core is found by interpolating between measured boundary values, using a differential form of the Arrhenius law governing pressure and temperature dependence. The discovery that both the retrograde and prograde free core nutations are in free decay (Palmer and Smylie, 2005) allows direct measures of viscosity at the top of the outer core, while the reduction in the rotational splitting of the two equatorial translational modes of the inner core allows it to be measured at the bottom. We find 2,371 plus/minus 1,530 Pa.s at the top and 1.247 plus/minus 0.035 x 10^11 Pa.s at the bottom. Following Brazhkin (1998) and Brazhkin and Lyapin (2000) who get 10^2 Pa.s at the top, 10^11 Pa.s at the bottom, by an Arrhenius extrapolation of laboratory experiments, we use a differential form of the Arrhenius law to interpolate along the melting temperature curve to find a viscosity profile across the outer core. We find the variation to be closely log-linear between the meas...

  3. Full MOX core for PWRs

    Energy Technology Data Exchange (ETDEWEB)

    Puill, A.; Aniel-Buchheit, S. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Direction des Reacteurs Nucleaires

    1997-12-31

    Plutonium management is a major problem of the back end of the fuel cycle. Fabrication costs must be reduced and plant operation simplified. The design of a full MOX PWR core would enable the number of reactors devoted to plutonium recycling to be reduced and fuel zoning to be eliminated. This paper is a contribution to the feasibility studies for achieving such a core without fundamental modification of the current design. In view of the differences observed between uranium and plutonium characteristics it seems necessary to reconsider the safety of a MOX-fuelled PWR. Reduction of the control worth and modification of the moderator density coefficient are the main consequences of using MOX fuel in a PWR. The core reactivity change during a draining or a cooling is thus of prime interest. The study of core global draining leads to the following conclusion: only plutonium fuels of very poor quality (i.e. with low fissile content) cannot be used in a 900 MWe PWR because of a positive global voiding reactivity effect. During a cooling accident, like an spurious opening of a secondary-side valve, the hypothetical return to criticality of a 100% MOX core controlled by means of 57 control rod clusters (made of hafnium-clad B{sub 4}C rods with a 90% {sup 10}B content) depends on the isotopic plutonium composition. But safety criteria can be complied with for all isotopic compositions provided the {sup 10}B content of the soluble boron is increased to a value of 40%. Core global draining and cooling accidents do not present any major obstacle to the feasibility of a 100% MOX PWR, only minor hardware modifications will be required. (author)

  4. Ice Core Dating Software for Interactive Dating of Ice Cores

    Science.gov (United States)

    Kurbatov, A. V.; Mayewski, P. A.; Abdul Jawad, B. S.

    2005-12-01

    Scientists involved in ice core dating are well familiar with the problem of identification and recording the depth of annual signals using stable isotopes, glaciochemistry, ECM (electrical conductivity), DEP (dielectric properties) and particle counter data. Traditionally all parameters used for ice core dating were plotted as a function of depth, printed and after years were marked on the paper, converted to depth vs. age time scale. To expedite this tedious and manual process we developed interactive computer software, Ice core Dating (ICD) program. ICD is written in Java programming language, and uses GPL and GPL site licensed graphic libraries. The same 3.5 Mb in size pre-compiled single jar file, that includes all libraries and application code, was successfully tested on WinOS, Mac OSX, Linux, and Solaris operating systems running Java VM version 1.4. We have followed the modular design philosophy in our source code so potential integration with other software modules, data bases and server side distributed computer environments can be easily implemented. We expect to continue development of new suites of tools for easy integration of ice core data with other available time proxies. ICD is thoroughly documented and comes with a technical reference and cookbook that explains the purpose of the software and its many features, and provides examples to help new users quickly become familiar with the operation and philosophy of the software. ICD is available as a free download from the Climate Change Institute web site ( under the terms of GNU GPL public license.

  5. Core physics analysis of 100% MOX core in IRIS

    Energy Technology Data Exchange (ETDEWEB)

    Franceschini, Fausto [Westinghouse Electric Company LLC, Science and Technology Department, Pittsburgh, PA 15235 (United States)], E-mail: FranceF@westinghouse.com; Petrovic, Bojan [Georgia Institute of Technology, Nuclear and Radiological Engineering, G.W. Woodruff School, Atlanta, GA 30332-0405 (United States)

    2008-09-15

    International Reactor Innovative and Secure (IRIS) is an advanced small-to-medium-size (1000 MWt) Pressurized Water Reactor (PWR), targeting deployment around 2015. Its reference core design is based on the current Westinghouse UO{sub 2} fuel with less than 5% {sup 235}U, and the analysis has been previously completed confirming good performance for that case. The full MOX fuel core is currently under evaluation as one of the alternatives for the second wave of IRIS reactors. A full 3-D neutronic analysis has been performed to examine main core performance and safety parameters, such as critical boron concentration, peaking factors, discharge burnup, reactivity coefficients, shut-down margin, etc. In addition, the basis to perform load follow maneuvers via the Westinghouse innovative strategy MSHIM has been established. The enhanced moderation of the IRIS fuel lattice facilitates MOX core design, and all the obtained results are within the operational and safety limits considered thus confirming viability of this option from the reactor physics standpoint.

  6. The myth of core stability.

    Science.gov (United States)

    Lederman, Eyal

    2010-01-01

    The principle of core stability has gained wide acceptance in training for the prevention of injury and as a treatment modality for rehabilitation of various musculoskeletal conditions in particular of the lower back. There has been surprisingly little criticism of this approach up to date. This article re-examines the original findings and the principles of core stability/spinal stabilisation approaches and how well they fare within the wider knowledge of motor control, prevention of injury and rehabilitation of neuromuscular and musculoskeletal systems following injury.

  7. Core-shell nanostructured catalysts.

    Science.gov (United States)

    Zhang, Qiao; Lee, Ilkeun; Joo, Ji Bong; Zaera, Francisco; Yin, Yadong

    2013-08-20

    Novel nanotechnologies have allowed great improvements in the syn-thesis of catalysts with well-controlled size, shape, and surface properties. Transition metal nanostructures with specific sizes and shapes, for instance, have shown great promise as catalysts with high selectivities and relative ease of recycling. Researchers have already demonstrated new selective catalysis with solution-dispersed or supported-metal nanocatalysts, in some cases applied to new types of reactions. Several challenges remain, however, particularly in improving the structural stability of the catalytic active phase. Core-shell nanostructures are nanoparticles encapsulated and protected by an outer shell that isolates the nanoparticles and prevents their migration and coalescence during the catalytic reactions. The synthesis and characterization of effective core-shell catalysts has been at the center of our research efforts and is the focus of this Account. Efficient core-shell catalysts require porous shells that allow free access of chemical species from the outside to the surface of nanocatalysts. For this purpose, we have developed a surface-protected etching process to prepare mesoporous silica and titania shells with controllable porosity. In certain cases, we can tune catalytic reaction rates by adjusting the porosity of the outer shell. We also designed and successfully applied a silica-protected calcination method to prepare crystalline shells with high surface area, using anatase titania as a model system. We achieved a high degree of control over the crystallinity and porosity of the anatase shells, allowing for the systematic optimization of their photocatalytic activity. Core-shell nanostructures also provide a great opportunity for controlling the interaction among the different components in ways that might boost structural stability or catalytic activity. For example, we fabricated a SiO₂/Au/N-doped TiO₂ core-shell photocatalyst with a sandwich structure that showed

  8. Core Task and Organizational Reality

    DEFF Research Database (Denmark)

    Vikkelsø, Signe

    2015-01-01

    of core objects such as ‘task’ and ‘coordination,’ contemporary organization studies emphasize, much like other social science disciplines, broader topics such as ‘network,’ ‘identity,’ and ‘change.’ The paper argues that this altered focus and vocabulary is accompanied by a diminished ability to specify...... and intervene into the practical reality of organizations. It further argues that a discipline's core objects are not anachronisms to be discarded with, but crucial for specifying reality in ways that have proven practically relevant and still are....

  9. Gelcasting Alumina Cores for Investment Casting

    Energy Technology Data Exchange (ETDEWEB)

    Janney, M A; Klug, F J

    2001-01-01

    General Electric currently uses silica investment casting cores for making superalloy turbine blades. The silica core technology does not provide the degree of dimensional control needed for advanced turbine system manufacture. The sum of the various process variables in silica core manufacturing produces cores that have more variability than is allowed for in advanced, power-generation gas turbine airfoils.

  10. Core Stability Training for Injury Prevention

    OpenAIRE

    Huxel Bliven, Kellie C.; Anderson, Barton E.

    2013-01-01

    Context: Enhancing core stability through exercise is common to musculoskeletal injury prevention programs. Definitive evidence demonstrating an association between core instability and injury is lacking; however, multifaceted prevention programs including core stabilization exercises appear to be effective at reducing lower extremity injury rates. Evidence Acquisition: PubMed was searched for epidemiologic, biomechanic, and clinical studies of core stability for injury prevention (keywords: ...

  11. One Health Core Competency Domains

    Directory of Open Access Journals (Sweden)

    Rebekah Frankson

    2016-09-01

    Full Text Available The emergence of complex global challenges at the convergence of human, animal, and environmental health has catalyzed a movement supporting ‘One Health’ approaches. Despite recognition of the importance of One Health approaches to address these complex challenges, little effort has been directed at identifying the seminal knowledge, skills and attitudes necessary for individuals to successfully contribute to One Health efforts. Between 2008 and 2011, three groups independently embarked on separate initiatives to identify core competencies for professionals involved with One Health approaches. Core competencies were considered critically important for guiding curriculum development and continuing professional education as they describe the knowledge, skills and attitudes required to be effective. A workshop was convened in 2012 to synthesize the various strands of work on One Health competencies. Despite having different mandates, participants, and approaches, all of these initiatives identified similar core competency domains: management; communication and informatics; values and ethics; leadership; teams and collaboration; roles and responsibilities; and systems thinking. These core competency domains have been used to develop new continuing professional education programs for One Health professionals and help university curricula prepare new graduates to be able to contribute more effectively to One Health approaches.

  12. Stability of Molten Core Materials

    Energy Technology Data Exchange (ETDEWEB)

    Layne Pincock; Wendell Hintze

    2013-01-01

    The purpose of this report is to document a literature and data search for data and information pertaining to the stability of nuclear reactor molten core materials. This includes data and analysis from TMI-2 fuel and INL’s LOFT (Loss of Fluid Test) reactor project and other sources.

  13. Core shift effect in blazars

    Science.gov (United States)

    Agarwal, A.; Mohan, P.; Gupta, Alok C.; Mangalam, A.; Volvach, A. E.; Aller, M. F.; Aller, H. D.; Gu, M. F.; Lähteenmäki, A.; Tornikoski, M.; Volvach, L. N.

    2017-07-01

    We studied the pc-scale core shift effect using radio light curves for three blazars, S5 0716+714, 3C 279 and BL Lacertae, which were monitored at five frequencies (ν) between 4.8 and 36.8 GHz using the University of Michigan Radio Astronomical Observatory (UMRAO), the Crimean Astrophysical Observatory (CrAO) and Metsähovi Radio Observatory for over 40 yr. Flares were Gaussian fitted to derive time delays between observed frequencies for each flare (Δt), peak amplitude (A) and their half width. Using A ∝ να, we infer α in the range of -16.67-2.41 and using Δ t ∝ ν ^{1/k_r}, we infer kr ∼ 1, employed in the context of equipartition between magnetic and kinetic energy density for parameter estimation. From the estimated core position offset (Ωrν) and the core radius (rcore), we infer that opacity model may not be valid in all cases. The mean magnetic field strengths at 1 pc (B1) and at the core (Bcore) are in agreement with previous estimates. We apply the magnetically arrested disc model to estimate black hole spins in the range of 0.15-0.9 for these blazars, indicating that the model is consistent with expected accretion mode in such sources. The power-law-shaped power spectral density has slopes -1.3 to -2.3 and is interpreted in terms of multiple shocks or magnetic instabilities.

  14. Fuzzy Cores and Fuzzy Balancedness

    NARCIS (Netherlands)

    van Gulick, G.; Norde, H.W.

    2011-01-01

    We study the relation between the fuzzy core and balancedness for fuzzy games. For regular games, this relation has been studied by Bondareva (1963) and Shapley (1967). First, we gain insight in this relation when we analyse situations where the fuzzy game is continuous. Our main result shows that

  15. Fuzzy cores and fuzzy balancedness

    NARCIS (Netherlands)

    van Gulick, G.; Norde, H.W.

    2013-01-01

    We study the relation between the fuzzy core and balancedness for fuzzy games. For regular games, this relation has been studied by Bondareva (Problemy Kibernet 10:119–139, 1963) and Shapley (Naval Res Logist Q 14: 453–460, 1967). First, we gain insight in this relation when we analyse situations

  16. Common Core: Fact vs. Fiction

    Science.gov (United States)

    Greene, Kim

    2012-01-01

    Despite students' interest in informational text, it has played second fiddle in literacy instruction for years. Now, though, nonfiction is getting its turn in the spotlight. The Common Core State Standards require that students become thoughtful consumers of complex, informative texts--taking them beyond the realm of dry textbooks and…

  17. Epistemology and ontology in core ontologies: FOLaw and LRI-Core, two core ontologies for law

    OpenAIRE

    Breukers, J.A.P.J.; Hoekstra, R.J.

    2004-01-01

    For more than a decade constructing ontologies for legal domains, we, at the Leibniz Center for Law, felt really the need to develop a core ontology for law that would enable us to re-use the common denominator of the various legal domains. In this paper we present two core ontologies for law. The first one was the result of a PhD thesis by [Valente, 1995], called FOLaw. FOLaw speci- fies functional dependencies between types of knowledge involved in legal reasoning. Despite the fact that FOL...

  18. Cores to the rescue: how old cores enable new science

    Science.gov (United States)

    Ito, E.; Noren, A. J.; Brady, K.

    2016-12-01

    The value of archiving scientific specimens and collections for the purpose of enabling further research using new analytical techniques, resolving conflicting results, or repurposing them for entirely new research, is often discussed in abstract terms. We all agree that samples with adequate metadata ought to be archived systematically for easy access, for a long time and stored under optimal conditions. And yet, as storage space fills, there is a temptation to cull the collection, or when a researcher retires, to discard the collection unless the researcher manages to make his or her own arrangement for the collection to be accessioned elsewhere. Nobody has done anything with these samples in over 20 years! Who would want them? It turns out that plenty of us do want them, if we know how to find them and if they have sufficient metadata to assess past work and suitability for new analyses. The LacCore collection holds over 33 km of core from >6700 sites in diverse geographic locations worldwide with samples collected as early as 1950s. From these materials, there are many examples to illustrate the scientific value of archiving geologic samples. One example that benefitted Ito personally were cores from Lakes Mirabad and Zeribar, Iran, acquired in 1963 by Herb Wright and his associates. Several doctoral and postdoctoral students generated and published paleoecological reconstructions based on cladocerans, diatoms, pollen or plant macrofossils, mostly between 1963 and 1967. The cores were resampled in 1990s by a student being jointly advised by Wright and Ito for oxygen isotope analysis of endogenic calcite. The results were profitably compared with pollen and the results published in 2001 and 2006. From 1979 until very recently, visiting Iran for fieldwork was not pallowed for US scientists. Other examples will be given to further illustrate the power of archived samples to advance science.

  19. Separated core turbofan engine; Core bunrigata turbofan engine

    Energy Technology Data Exchange (ETDEWEB)

    Saito, Y.; Endo, M.; Matsuda, Y.; Sugiyama, N.; Sugahara, N.; Yamamoto, K. [National Aerospace Laboratory, Tokyo (Japan)

    1996-04-01

    This report outlines the separated core turbofan engine. This engine is featured by parallel separated arrangement of a fan and core engine which are integrated into one unit in the conventional turbofan engine. In general, cruising efficiency improvement and noise reduction are achieved by low fan pressure ratio and low exhaust speed due to high bypass ratio, however, it causes various problems such as large fan and nacelle weight due to large air flow rate of a fan, and shift of an operating point affected by flight speed. The parallel separated arrangement is thus adopted. The stable operation of a fan and core engine is easily retained by independently operating air inlet unaffected by fan. The large degree of freedom of combustion control is also obtained by independent combustor. Fast response, simple structure and optimum aerodynamic design are easily achieved. This arrangement is also featured by flexibility of development and easy maintenance, and by various merits superior to conventional turbofan engines. It has no technological problems difficult to be overcome, and is also suitable for high-speed VTOL transport aircraft. 4 refs., 5 figs.

  20. Espaço de cores

    Directory of Open Access Journals (Sweden)

    Claudia Feitosa-Santana

    2006-01-01

    Full Text Available O artigo apresenta definições para os termos espaço de cores e sistemas de cores; classifica, de acordo com David Brainard (2003, os sistemas de cores em dois grupos: aparência de cores e diferenças de cores. Dentre os diversos sistemas de cores existentes, o artigo descreve dois deles: o sistema de cores Munsell &– um dos mais utilizados entre os sistemas de aparência de cores &– e a descrição do sistema de cores CIE 1931 &– um dos mais utilizados dentre os sistemas de diferença de cores. Faz-se uma retrospectiva histórica da busca por espaços de cores que representem a percepção de cores humana assim como as diversas reconstruções de espaços de cores por métodos eletrofisiológicos ou psicofísicos. Muitas dessas reconstruções utilizam a escala multidimensional (mds. O artigo também introduz a possibilidade da reconstrução dos espaços de cores de pacientes com discromatopsia adquirida como uma distorção do espaço de indivíduos tricromatas normais.

  1. Conceptual study of advanced PWR core design

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin; Chang, Moon Hee; Kim, Keung Ku; Joo, Hyung Kuk; Kim, Young Il; Noh, Jae Man; Hwang, Dae Hyun; Kim, Taek Kyum; Yoo, Yon Jong

    1997-09-01

    The purpose of this project is for developing and verifying the core design concepts with enhanced safety and economy, and associated methodologies for core analyses. From the study of the sate-of-art of foreign advanced reactor cores, we developed core concepts such as soluble boron free, high convertible and enhanced safety core loaded semi-tight lattice hexagonal fuel assemblies. To analyze this hexagonal core, we have developed and verified some neutronic and T/H analysis methodologies. HELIOS code was adopted as the assembly code and HEXFEM code was developed for hexagonal core analysis. Based on experimental data in hexagonal lattices and the COBRA-IV-I code, we developed a thermal-hydraulic analysis code for hexagonal lattices. Using the core analysis code systems developed in this project, we designed a 600 MWe core and studied the feasibility of the core concepts. Two additional scopes were performed in this project : study on the operational strategies of soluble boron free core and conceptual design of large scale passive core. By using the axial BP zoning concept and suitable design of control rods, this project showed that it was possible to design a soluble boron free core in 600 MWe PWR. The results of large scale core design showed that passive concepts and daily load follow operation could be practiced. (author). 15 refs., 52 tabs., 101 figs.

  2. Whole Core Transport Calculation Methodology for a Hexagonal Core

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Kim, K. S.; Lee, C. C.; Zee, S. Q.; Joo, H. G

    2007-07-15

    This report discusses the hexagonal module implemented to the DeCART code and the performance of them. The implemented hexagonal module includes the hexagonal ray tracing and the CMFD acceleration modules. The performance of the implemented hexagonal module is examined for 4 tests of: (1) CMFD acceleration test, (2) the accuracy test of the hexagonal module, (3) the performance test for 2-D NGNP problem and (4) the applicability test for 3-D NGNP problem. The features of the implemented hexagonal modules are: (1) The Modular ray tracing scheme based on a hexagonal assembly and a path linking scheme between the modular rays. (2) Segment generation based on the structure unit. (3) Cell ray approximation: This feature is developed to reduce the memory required to store the segment information. (4) Modified cycle ray scheme that begins the ray tracing at a given surface and finishes if the reflected ray meets the starting surface. This feature is developed to reduce the memory required for the angular flux at the core boundary. (5) Fixed assembly geometry. The pin geometry of the single pin per assembly problem is different from that of the multi-pin problem. The core geometry of a single assembly problem is also different from that of the multi-assembly problem. (6) CMFD module based on unstructured cell. This feature is to deal with the irregular gap cells that are positioned at the assembly boundaries. The examination results of the 4 tests can be summarized as: (1) The CMFD acceleration test shows that the CMFD module speedups about greater than 200 for the core problem. (2) The accuracy test shows that the hexagonal MOC module produces an accurate solution of less than 60 pcm of eigenvalue and less than 2 % of local pin power errors. (3) The performance test for 2-D NGNP problem shows that the implemented hexagonal module works soundly and produces a reasonable solution by cooperating with the existing DeCART library and the other modules. (4) The applicability

  3. Continuous Chemistry in Ice Cores

    DEFF Research Database (Denmark)

    Kjær, Helle Astrid

    corrections. Further the method successfully identified volcanic eruptions as well as the underlying anthropogenic signal related to the industrial pollution peaking in the 1970’s. The pH method was also applied on the Antarctic RICE ice core and proved useful, contrary to both the ECM and melt water......Ice cores provide high resolution records of past climate and environment. In recent years the use of continuous flow analysis (CFA) systems has increased the measurement throughput, while simultaneously decreasing the risk of contaminating the ice samples. CFA measurements of high temporal...... for the continuous determination of dissolved reactive phosphorus (DRP) by means of a reaction with molybdenum blue. The concentration of DRP in polar ice is low and thus the method relies on enhancing the limit of detection by increasing the absorption length by means of a 2.5 metre LiquidWaveguide Capillary Cell...

  4. Early Evolution of Prestellar Cores

    Science.gov (United States)

    Horedt, G. P.

    2013-08-01

    Prestellar cores are approximated by singular polytropic spheres. Their early evolution is studied analytically with a Bondi-like scheme. The considered approximation is meaningful for polytropic exponents γ between 0 and 6/5, implying radial power-law density profiles between r -1 and r -2.5. Gravitationally unstable Jeans and Bonnor-Ebert masses differ at most by a factor of 3.25. Tidally stable prestellar cores must have a mean density contrast >~ 8 with respect to the external parent cloud medium. The mass-accretion rate relates to the cube of equivalent sound speed, as in Shu's seminal paper. The prestellar masses accreted over 105 years cover the whole stellar mass spectrum; they are derived in simple closed form, depending only on the polytropic equation of state. The stellar masses that can be formed via strict conservation of angular momentum are at most of the order of a brown dwarf.

  5. Accelerator driven sub-critical core

    Science.gov (United States)

    McIntyre, Peter M; Sattarov, Akhdiyor

    2015-03-17

    Systems and methods for operating an accelerator driven sub-critical core. In one embodiment, a fission power generator includes a sub-critical core and a plurality of proton beam generators. Each of the proton beam generators is configured to concurrently provide a proton beam into a different area of the sub-critical core. Each proton beam scatters neutrons within the sub-critical core. The plurality of proton beam generators provides aggregate power to the sub-critical core, via the proton beams, to scatter neutrons sufficient to initiate fission in the sub-critical core.

  6. Divergent Chemoenzymatic Synthesis of Asymmetrical-Core-Fucosylated and Core-Unmodified N-Glycans

    NARCIS (Netherlands)

    Li, Tiehai; Huang, Min; Liu, Lin; Wang, Shuo; Moremen, Kelley W; Boons, Geert-Jan|info:eu-repo/dai/nl/088245489

    2016-01-01

    A divergent chemoenzymaytic approach for the preparation of core-fucosylated and core-unmodified asymmetrical N-glycans from a common advances precursor is described. An undecasaccharide was synthesized by sequential chemical glycosylations of an orthogonally protected core fucosylated

  7. Superconducting Vortex with Antiferromagnetic Core

    Energy Technology Data Exchange (ETDEWEB)

    Arovas, D.P. [Department of Physics, University of California at San Diego, La Jolla, California 92093 (United States); Berlinsky, A.J.; Kallin, C.; Zhang, S. [Department of Physics, Stanford University, Stanford, California 94305 (United States)

    1997-10-01

    We show that a superconducting vortex in underdoped high T{sub c} superconductors could have an antiferromagnetic core. This type of vortex configuration arises as a topological solution in the recently constructed SO(5) nonlinear {sigma} model and in Landau-Ginzburg theory with competing antiferromagnetic and superconducting order parameters. Experimental detection of this type of vortex by muon spin resonance and neutron scattering is proposed. {copyright} {ital 1997} {ital The American Physical Society}

  8. Core curriculum illustration: rib fractures.

    Science.gov (United States)

    Dunham, Gregor M; Perez-Girbes, Alexandre; Linnau, Ken F

    2017-06-01

    This is the 24th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at http://www.aseronline.org/curriculum/toc.htm .

  9. Core curriculum illustration: epiploic appendagitis.

    Science.gov (United States)

    Perez-Girbes, Alexandre; Alegre, Alberto; Linnau, Ken F

    2017-10-12

    This is the 45th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at: http://www.erad.org/page/CCIP_TOC .

  10. Core curriculum illustration: pulmonary laceration.

    Science.gov (United States)

    Carson, Daniel; Edwards, Rachael

    2017-09-05

    This is the 44th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at: http://www.erad.org/page/CCIP_TOC .

  11. Rich-cores in networks

    CERN Document Server

    Ma, Athen

    2014-01-01

    A core is said to be a group of central and densely connected nodes which governs the overall behavior of a network. Profiling this meso--scale structure currently relies on a limited number of methods which are often complex, and have scalability issues when dealing with very large networks. As a result, we are yet to fully understand its impact on network properties and dynamics. Here we introduce a simple method to profile this structure by combining the concepts of core/periphery and rich-club. The key challenge in addressing such association of the two concepts is to establish a way to define the membership of the core. The notion of a "rich-club" describes nodes which are essentially the hub of a network, as they play a dominating role in structural and functional properties. Interestingly, the definition of a rich-club naturally emphasizes high degree nodes and divides a network into two subgroups. Our approach theoretically couples the underlying principle of a rich-club with the escape time of a rand...

  12. Coring in deep hardrock formations

    Energy Technology Data Exchange (ETDEWEB)

    Drumheller, D.S.

    1988-08-01

    The United States Department of Energy is involved in a variety of scientific and engineering feasibility studies requiring extensive drilling in hard crystalline rock. In many cases well depths extend from 6000 to 20,000 feet in high-temperature, granitic formations. Examples of such projects are the Hot Dry Rock well system at Fenton Hill, New Mexico and the planned exploratory magma well near Mammoth Lakes, California. In addition to these programs, there is also continuing interest in supporting programs to reduce drilling costs associated with the production of geothermal energy from underground sources such as the Geysers area near San Francisco, California. The overall progression in these efforts is to drill deeper holes in higher temperature, harder formations. In conjunction with this trend is a desire to improve the capability to recover geological information. Spot coring and continuous coring are important elements in this effort. It is the purpose of this report to examine the current methods used to obtain core from deep wells and to suggest projects which will improve existing capabilities. 28 refs., 8 figs., 2 tabs.

  13. Core stability training for injury prevention.

    Science.gov (United States)

    Huxel Bliven, Kellie C; Anderson, Barton E

    2013-11-01

    Enhancing core stability through exercise is common to musculoskeletal injury prevention programs. Definitive evidence demonstrating an association between core instability and injury is lacking; however, multifaceted prevention programs including core stabilization exercises appear to be effective at reducing lower extremity injury rates. PUBMED WAS SEARCHED FOR EPIDEMIOLOGIC, BIOMECHANIC, AND CLINICAL STUDIES OF CORE STABILITY FOR INJURY PREVENTION (KEYWORDS: "core OR trunk" AND "training OR prevention OR exercise OR rehabilitation" AND "risk OR prevalence") published between January 1980 and October 2012. Articles with relevance to core stability risk factors, assessment, and training were reviewed. Relevant sources from articles were also retrieved and reviewed. Stabilizer, mobilizer, and load transfer core muscles assist in understanding injury risk, assessing core muscle function, and developing injury prevention programs. Moderate evidence of alterations in core muscle recruitment and injury risk exists. Assessment tools to identify deficits in volitional muscle contraction, isometric muscle endurance, stabilization, and movement patterns are available. Exercise programs to improve core stability should focus on muscle activation, neuromuscular control, static stabilization, and dynamic stability. Core stabilization relies on instantaneous integration among passive, active, and neural control subsystems. Core muscles are often categorized functionally on the basis of stabilizing or mobilizing roles. Neuromuscular control is critical in coordinating this complex system for dynamic stabilization. Comprehensive assessment and training require a multifaceted approach to address core muscle strength, endurance, and recruitment requirements for functional demands associated with daily activities, exercise, and sport.

  14. CORE SHAPES AND ORIENTATIONS OF CORE-SÉRSIC GALAXIES

    Energy Technology Data Exchange (ETDEWEB)

    Dullo, Bililign T.; Graham, Alister W., E-mail: Bdullo@astro.swin.edu.au [Centre for Astrophysics and Supercomputing, Swinburne University of Technology, Hawthorn, Victoria 3122 (Australia)

    2015-01-01

    The inner and outer shapes and orientations of core-Sérsic galaxies may hold important clues to their formation and evolution. We have therefore measured the central and outer ellipticities and position angles for a sample of 24 core-Sérsic galaxies using archival Hubble Space Telescope (HST) images and data. By selecting galaxies with core-Sérsic break radii R{sub b} —a measure of the size of their partially depleted core—that are ≳ 0.''2, we find that the ellipticities and position angles are quite robust against HST seeing. For the bulk of the galaxies, there is a good agreement between the ellipticities and position angles at the break radii and the average outer ellipticities and position angles determined over R {sub e}/2 < R < R {sub e}, where R {sub e} is the spheroids' effective half light radius. However there are some interesting differences. We find a median ''inner'' ellipticity at R{sub b} of ε{sub med} = 0.13 ± 0.01, rounder than the median ellipticity of the ''outer'' regions ε{sub med} = 0.20 ± 0.01, which is thought to reflect the influence of the central supermassive black hole at small radii. In addition, for the first time we find a trend, albeit weak (2σ significance), such that galaxies with larger (stellar deficit-to-supermassive black hole) mass ratios—thought to be a measure of the number of major dry merger events—tend to have rounder inner and outer isophotes, suggesting a connection between the galaxy shapes and their merger histories. We show that this finding is not simply reflecting the well known result that more luminous galaxies are rounder, but it is no doubt related.

  15. High Efficiency Solar Furnace Core Project

    Data.gov (United States)

    National Aeronautics and Space Administration — It is proposed to develop a high efficiency solar furnace core that greatly lessens the heat losses from the furnace core, either greatly reducing the amount of...

  16. BWR MOX core monitoring at Kernkraftwerk Gundremmingen

    Energy Technology Data Exchange (ETDEWEB)

    Noel, Alejandro [Studsvik Scandpower (Suisse) GmbH, Nussbaumen AG (Switzerland); Holzer, Robert [NIS Ingenieurgesellschaft GmbH, Alzenau (Germany); Anton, Gerd [Studsvik Scandpower GmbH, Norderstedt (Germany); Smith, Kord [Studsvik Scandpower Inc., Idaho Falls (United States)

    2008-07-01

    The replacement of the core monitoring system for twin KWU Boiling Water Reactors (BWR) is presented. The reactors, Kernkraftwerk Gundremmingen B and C (KGG), are located in Germany. Core monitoring for KGG is more challenging than for most BWR reactors due to its core composition with about 30% MOX fuel assemblies. The objectives of this paper are to discuss the specific MOX modelling aspects in CASMO-4/Simulate-3, the impact of the MOX fuel on several core monitoring aspects like the LPRM detector modelling and to present some core monitoring results since the beginning of GARDEL's operation. The available core monitoring results confirm the accuracy of the underlying physical methods. The core monitoring system replacement att KGG was a common project of Studsvik Scandpower and NIS Ingenieurgesellschaft GmbH, where Studsvik Scandpower supplied its standard core monitoring system GARDEL and NIS was responsible for the computer hardware, system integration and plant specific add-ons. (authors)

  17. Optimized Cellular Core for Rotorcraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Patz Materials and Technologies has developed, produced and tested, as part of the Phase-I SBIR, a new form of composite cellular core material, named Interply Core,...

  18. Core Stability of Vertex Cover Games

    OpenAIRE

    Fang, Qizhi; Kong, Liang; Zhao, Jia

    2008-01-01

    In this paper, we focus on the core stability of vertex cover games, which arise from vertex cover problems on graphs. Based on duality theory of linear programming, we prove that a balanced vertex cover game has a stable core if and only if every edge belongs to a maximum matching in the underlying graph. We also prove that for a totally balanced vertex cover game, the core largeness, extendability, and exactness are all equivalent, which implies core stability. Furtherm...

  19. Core Processes: Earth's eccentric magnetic field

    DEFF Research Database (Denmark)

    Finlay, Chris

    2012-01-01

    Earth’s magnetic field is characterized by a puzzling hemispheric asymmetry. Calculations of core dynamo processes suggest that lopsided growth of the planet’s inner core may be part of the cause.......Earth’s magnetic field is characterized by a puzzling hemispheric asymmetry. Calculations of core dynamo processes suggest that lopsided growth of the planet’s inner core may be part of the cause....

  20. Characterizing core stability with fuzzy games

    OpenAIRE

    Shellshear, Evan

    2009-01-01

    This paper investigates core stability of cooperative, TU games via a fuzzy extension of the totally balanced cover of a TU game. The stability of the core of the fuzzy extension of a game, the concave extension, is shown to reflect the core stability of the original game and vice versa. Stability of the core is then shown to be equivalent to the existence of an equilibrium of a certain correspondence.

  1. Core trénink ve florbale

    OpenAIRE

    Mašková, Alžběta

    2014-01-01

    Title: Use of core training in floorball Objectives: Present an overview of research papers regarding core training and its possible use in floorball Tasks: First aim of this thesis is to provide description and explanation of the core training by using available literature, research papers, bachelor or magister thesis and also thesis of the coaching school. Second aim is to analyze the necessary components of floorball player's performance relative to the core training. This is followed by a...

  2. Influence of core electrons on plasmon oscillations

    Science.gov (United States)

    Lipparini, E.; Pederiva, Francesco

    1993-09-01

    Core electrons constitute a polarizable background which tends to screen the plasma oscillations. The influence of core electrons on plasmon dispersion is studied with sum rule techniques. Analytical expressions are derived for the surface plasmon of flat surfaces and of small metal particles. Core polarization explains semiquantitatively the blue-shift of the surface plasmon recently observed in silver systems.

  3. Mars: a new core-crystallization regime

    NARCIS (Netherlands)

    Stewart, A.J.; Schmidt, M.W.; van Westrenen, W.; Liebske, C.

    2007-01-01

    The evolution of the martian core is widely assumed to mirror the characteristics observed for Earth's core. Data from experiments performed on iron-sulfur and iron-nickel-sulfur systems at pressures corresponding to the center of Mars indicate that its core is presently completely liquid and that

  4. Common Core: Teaching Optimum Topic Exploration (TOTE)

    Science.gov (United States)

    Karge, Belinda Dunnick; Moore, Roxane Kushner

    2015-01-01

    The Common Core has become a household term and yet many educators do not understand what it means. This article explains the historical perspectives of the Common Core and gives guidance to teachers in application of Teaching Optimum Topic Exploration (TOTE) necessary for full implementation of the Common Core State Standards. An effective…

  5. Simplifying the ELA Common Core; Demystifying Curriculum

    Science.gov (United States)

    Schmoker, Mike; Jago, Carol

    2013-01-01

    The English Language Arts (ELA) Common Core State Standards ([CCSS], 2010) could have a transformational effect on American education. Though the process seems daunting, one can begin immediately integrating the essence of the ELA Common Core in every subject area. This article shows how one could implement the Common Core and create coherent,…

  6. Improving Core Strength to Prevent Injury

    Science.gov (United States)

    Oliver, Gretchen D.; Adams-Blair, Heather R.

    2010-01-01

    Regardless of the sport or skill, it is essential to have correct biomechanical positioning, or postural control, in order to maximize energy transfer. Correct postural control requires a strong, stable core. A strong and stable core allows one to transfer energy effectively as well as reduce undue stress. An unstable or weak core, on the other…

  7. Full MOX core design for PWR

    Energy Technology Data Exchange (ETDEWEB)

    Komano, Y.; Tochihara, H.; Ishida, M. [Mitsubishi Heavy Industries Ltd., Tokyo (Japan)

    1999-12-01

    Full MOX core design for APWR was analyzed in nuclear design, fuel integrity analysis, thermal hydraulic design and safety analysis et. al. Feasibility of Full MOX core was confirmed from these analyses without any large modifications. Full MOX PWR core has very good characteristics in which single Pu content in an assembly, burnable poison free, higher burnup and longer cycle operation are feasible. (author)

  8. Reinforcement core facilitates O-ring installation

    Science.gov (United States)

    1965-01-01

    Reinforcement core holds O-ring in place within a structure while adjacent parts are being assembled. The core in the O-ring adds circumferential rigidity to the O-ring material. This inner core does not appreciably affect the sectional elasticity or gland-sealing characteristics of the O-ring.

  9. Heterogeneity and anisotropy of Earth's inner core

    NARCIS (Netherlands)

    Deuss, Arwen|info:eu-repo/dai/nl/412396610

    2014-01-01

    Seismic observations provide strong evidence that Earth's inner core is anisotropic, with larger velocity in the polar than in the equatorial direction. The top 60-80 km of the inner core is isotropic; evidence for an innermost inner core is less compelling. The anisotropy is most likely due to

  10. Identifying Core vs. Non-Core Activities of Household Members

    Directory of Open Access Journals (Sweden)

    Mahdieh Allahviranloo

    2016-02-01

    Full Text Available Understanding scheduling behavior of households has been the focus of research for nearly half a century. Presumably activity engagement is being impacted by the importance of the activity to household members as well as time and cost constraints. Depending on the level of time budget, household members would eliminates some activities from the agenda or replace them with higher priority ones. In this paper, in order to capture the importance of different activities, we propose a methodology to schedule household activities under different levels of uncertainty about the importance of the activity. In this approach we combine discrete choice models and concepts of Fuzzy logic to identify core versus non-core activities in the agenda. The possibility of inclusion of an activity is the agenda is computed by estimating the expected importance of the activity and mapping to a set of fuzzy graphs. Activity scheduling and selection is then modeled as the outcome of a mixed integer optimization problem, in which the objective function is maximizing the expected desirability gained from activities and total saved time, subject to network connectivity, time windows, time budget and cost budget constraints.

  11. ARTEMISTM Core Simulator: Latest Developments

    Science.gov (United States)

    Hobson, Greg; Bolloni, Hans-Wilhelm; Breith, Karl-Albert; Dall'Osso, Aldo; van Geemert, René; Haase, Hartmut; Hartmann, Bettina; Leberig, Mario; Porsch, Dieter; Pothet, Baptiste; Riedmann, Michael; Sieber, Galina; Tomatis, Daniele

    2014-06-01

    AREVA has developed a new coupled neutronics/thermal-hydraulics code system, ARCADIA®. It makes use of modern computing resources to enable more realistic reactor analysis as improved understanding of nuclear reactor behavior is the basis for efficient margin management, i.e. optimization of safety and performance. One of the principal components of this new system is the core simulator, ARTEMIS™. The purpose of this paper is to recall its features, present the latest developments and give a summary of the validation tests.

  12. HPLWR fine mesh core analysis

    Energy Technology Data Exchange (ETDEWEB)

    Temesvari, E.; Maraczy, C.; Hegyi, G.; Hordosy, G.; Molnar, A. [Hungarian Academy of Sciences, Budapest (Hungary). Centre for Energy Research

    2014-08-15

    The European version of Supercritical Water Reactors (SCWR), the High Performance Light Water Reactor (HPLWR) operates in the thermodynamically supercritical region of water. Our basic objective was to elaborate a stationary coupled neutronic-thermohydraulic code capable for the calculation of the actual 3-pass core design with fuel assembly clusters. The calculations covered the neutronic transport calculations of HPLWR fuel assemblies, the coupled neutronic-thermohydraulic global calculations and the pin-wise analysis. Applying conservative assumptions, the relation to the linear heat rate and maximum cladding temperature limits was checked for the equilibrium cycle of HPLWR with this new code system.

  13. Inner Core Anisotropy in Attenuation

    Science.gov (United States)

    Yu, W.; Wen, L.

    2004-12-01

    It is now well established that the compressional velocity in the Earth's inner core varies in both direction and geographic location. The compressional waves travel faster along the polar directions than along the equatorial directions. Such polar-equatorial difference is interpreted as a result of inner core anisotropy in velocity (with a magnitude of about 3%) and such anisotropy appears to be stronger in the ``western hemisphere" (180oW -40oE) than in the ``eastern hemisphere" (40oE-180oE). Along the equatorial paths, the compressional velocity also exhibits a hemispheric pattern with the eastern hemisphere being about 1% higher than the western hemisphere. Possible explanations for the causes of the velocity in anisotropy and the hemispheric difference in velocity along the equatorial paths include different geometric inclusions of melt or different alignments of iron crystals which are known to be anisotropic in velocities. Here, we report an observation of ubiquitous correlation between small (large) amplitude and fast (slow) travel time of the PKIKP waves sampling the top 300 km of the inner core. We study this correlation by jointly analyzing the differential travel times and amplitude ratios of the PKiKP-PKIKP and the PKPbc-PKIKP phases recorded by the Global Seismographic Network (1990-2001), various regional seismic networks (BANJO, BLSP, FREESIA, GEOFON, GEOSCOPE, Kazakhstan, Kyrgyz, MEDNET, and OHP), and several PASSCAL Networks deployed in Alaska and Antarctica (XE: 1999-2001, XF: 1995-1996, and YI: 1998-1999). Our dataset consists of 310 PKiKP-PKIKP and 240 PKPbc-PKIKP phases, selected from a total of more than 16,000 observations. PKIKP waves exhibit relatively smaller amplitudes for those sampling the eastern hemisphere along the equatorial paths and even smaller amplitudes for those sampling the polar paths in the western hemisphere. One simple explanation for the velocity-attenuation relation is that the inner core is anisotropic in attenuation

  14. Double U-Core Switched Reluctance Machine

    DEFF Research Database (Denmark)

    2016-01-01

    The present invention relates to an electrical machine stator comprising a plurality of stator segments (131,132,133), each segment comprises a first U-core and a second U-core wound with a winding, where the winding being arranged with at least one coil turn, each coil turn comprises a first axial......(s), wherein the first U-core and the second U-core are located adjacent to each other, whereby the winding spans the first and second U-cores. The invention also relates to a SRM machine with a stator mentioned above and a rotor....

  15. Hydrophilic-Core Microcapsules and Their Formation

    Science.gov (United States)

    Calle, Luz M. (Inventor); Li, Wenyan (Inventor); Buhrow, Jerry W. (Inventor); Jolley, Scott T. (Inventor)

    2016-01-01

    Hydrophilic-core microcapsules and methods of their formation are provided. A hydrophilic-core microcapsule may include a shell that encapsulates water with the core substance dissolved or dispersed therein. The hydrophilic-core microcapsules may be formed from an emulsion having hydrophilic-phase droplets dispersed in a hydrophobic phase, with shell-forming compound contained in the hydrophilic phase or the hydrophobic phase and the core substance contained in the hydrophilic phase. The shells of the microcapsules may be capable of being broken down in response to being contacted by an alkali, e.g., produced during corrosion, contacting the shell.

  16. Hydrophobic-Core Microcapsules and Their Formation

    Science.gov (United States)

    Calle, Luz M. (Inventor); Li, Wenyan (Inventor); Buhrow, Jerry W. (Inventor); Jolley, Scott T. (Inventor)

    2016-01-01

    Hydrophobic-core microcapsules and methods of their formation are provided. A hydrophobic-core microcapsule may include a shell that encapsulates a hydrophobic substance with a core substance, such as dye, corrosion indicator, corrosion inhibitor, and/or healing agent, dissolved or dispersed therein. The hydrophobic-core microcapsules may be formed from an emulsion having hydrophobic-phase droplets, e.g., containing the core substance and shell-forming compound, dispersed in a hydrophilic phase. The shells of the microcapsules may be capable of being broken down in response to being contacted by an alkali, e.g., produced during corrosion, contacting the shell.

  17. Nitride stabilized core/shell nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Kuttiyiel, Kurian Abraham; Sasaki, Kotaro; Adzic, Radoslav R.

    2018-01-30

    Nitride stabilized metal nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a continuous and nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling. The nitride stabilized nanoparticles may be fabricated by a process in which a core is coated with a shell layer that encapsulates the entire core. Introduction of nitrogen into the core by annealing produces metal nitride(s) that are less susceptible to dissolution during potential cycling under high oxidizing conditions.

  18. Comparison of gravity-resisted and gym-based core training on core ...

    African Journals Online (AJOL)

    Conditioning specialists have been incorporating concepts of gravity-resisted core training, both on stable and unstable surfaces, to enhance core endurance despite limited empirical evidence. The purpose of this study was to compare the effects of gravity-resisted and gym-based core training on core endurance.

  19. 77 FR 30435 - In-core Thermocouples at Different Elevations and Radial Positions in Reactor Core

    Science.gov (United States)

    2012-05-23

    ... COMMISSION 10 CFR Part 50 In-core Thermocouples at Different Elevations and Radial Positions in Reactor Core... ``require all holders of operating licenses for nuclear power plants (``NPP'') to operate NPPs with in-core thermocouples at different elevations and radial positions throughout the reactor core.'' DATES: Submit comments...

  20. Research on plasma core reactors

    Science.gov (United States)

    Jarvis, G. A.; Barton, D. M.; Helmick, H. H.; Bernard, W.; White, R. H.

    1976-01-01

    Experiments and theoretical studies are being conducted for NASA on critical assemblies with one-meter diameter by one-meter long low-density cores surrounded by a thick beryllium reflector. These assemblies make extensive use of existing nuclear propulsion reactor components, facilities, and instrumentation. Due to excessive porosity in the reflector, the initial critical mass was 19 kg U(93.2). Addition of a 17 cm thick by 89 cm diameter beryllium flux trap in the cavity reduced the critical mass to 7 kg when all the uranium was in the zone just outside the flux trap. A mockup aluminum UF6 container was placed inside the flux trap and fueled with uranium-graphite elements. Fission distributions and reactivity worths of fuel and structural materials were measured. Finally, an 85,000 cu cm aluminum canister in the central region was fueled with UF6 gas and fission density distributions determined. These results are to be used to guide the design of a prototype plasma core reactor which will test energy removal by optical radiation.

  1. Drilling history core hole DC-8

    Energy Technology Data Exchange (ETDEWEB)

    1978-10-01

    Core hole DC-8 was completed in August, 1978 by Boyles Brothers Drilling Company, Spokane, Washington, under subcontract to Fenix and Scission, Inc. The hole was cored for the US Department of Energy and the Rockwell Hanford Operations' Basalt Waste Isolation Program. Fenix and Scisson, Inc. furnished the engineering, daily supervision of the core drilling activities, and geologic core logging for hole DC-8. Core hole DC-8 is located on the Hanford Site near the Wye Barricade and 50 feet northwest of rotary hole DC-7. The Hanford Site vation coordinates for DC-8 are North 14,955.94 feet and West 14,861.92 coordinates for DC-8 are North 14,955.94 feet and West 14,861.92 mean sea level. The purpose of core hole DC-8 was to core drill vertically through the basalt and interbed units for stratigraphic depth determination and core collection, and to provide a borehole for hydrologic testing and cross-hole seismic shear and pressure wave velocity studies with rotary hole DC-7. The total depth of core hole DC-8 was 4100.5 feet. Core recovery exceeded 97 percent of the total footage cored.

  2. Functional Screening of Core Promoter Activity.

    Science.gov (United States)

    Even, Dan Y; Kedmi, Adi; Ideses, Diana; Juven-Gershon, Tamar

    2017-01-01

    The core promoter is the DNA sequence that recruits the basal transcription machinery and directs accurate initiation of transcription. It is an active contributor to gene expression that can be rationally designed to manipulate the levels of expression. Core promoter function can be analyzed using different experimental approaches. Here, we describe the qualitative and quantitative analysis of engineered core promoter functions using the EGFP reporter gene that is driven by distinct core promoters. Expression plasmids are transfected into different mammalian cell lines, and the resulting fluorescence is monitored by live cell imaging , as well as by flow cytometry. In order to verify that the transcriptional activity of the examined core promoters is indeed a function of their activity, as opposed to differences in DNA uptake, real-time quantitative PCR analysis is performed. Importantly, the described methodology for functional screening of core promoter activity has enabled the analysis of engineered potent core promoters for extended time periods.

  3. Transport Properties of Earth's Core

    Science.gov (United States)

    Cohen, R. E.; Zhang, P.; Xu, J.

    2016-12-01

    One of the most important parameters governing the original heat that drives all processes in the Earth is the thermal conductivity of Earth's core. Heat is transferred through the core by convection and conduction, and the convective component provides energy to drive the geodynamo. Sha and Cohen (2011) found that the electrical conductivity of solid hcp-iron was much higher than had been assumed by geophysicists, based on electronic structure computations for electron-phonon scattering (e-p) within density functional theory [1]. Thermal conductivity is related to electrical conductivity through the empirical Wiedmann-Franz law of 1853 [2]. Pozzo et al. [3] found that the high electrical conductivity of liquid iron alloys was too high for conventional dynamo models to work—there simply is not enough energy, so O'Rourke and Stevenson proposed a model driven by participation of Mg from the core [4], supported by recent experients [5]. Recent measurements by Ohta et al. show even lower resistivities than predicted by DFT e-p, and invoked a saturation model to account for this, [6] whereas, Konopkova et al. found thermal conductivities consistent with earlier geophysical estimates. [7] We are using first-principles methods, including dynamical mean field theory for electron-electron scattering, and highly converged e-p computations, and find evidence for strong anisotropy in solid hcp-Fe that may help explain some experimental results. The current status of the field will be discussed along with our recent results. This work is supported by the ERC Advanced grant ToMCaT, the NSF, and the Carnegie Institution for Science.[1] X. Sha and R. E. Cohen, J.Phys.: Condens.Matter 23, 075401 (2011).[2] R. Franz and G. Wiedemann, Annalen Physik 165, 497 (1853).[3] M. Pozzo, C. Davies, D. Gubbins, and D. Alfe, Nature 485, 355 (2012).[4] J. G. O'Rourke and D. J. Stevenson, Nature 529, 387 (2016).[5] J. Badro, J. Siebert, and F. Nimmo, Nature (2016).[6] K. Ohta, Y. Kuwayama, K

  4. The Transcendental Core of Correlationism

    Directory of Open Access Journals (Sweden)

    Paul J. Ennis

    2011-06-01

    Full Text Available In this paper I read Quentin Meillassoux’s critique of correlationism as truly a critique of transcendentalism and the transcendental method. I do so by considering the two correlationist rejoinders that occur in the English edition of Meillassoux’s After Finitude. The first rejoinder is from an idealist and relies on adumbrations for its defence. This reliance on adumbrations will be shown to be itself transcendentally implicated through Edmund Husserl’s Crisis of the European Sciences and Transcendental Phenomenology. I then turn to the explicit engagement with the transcendental method that arises from the transcendentalist’s rejoinder. Considered together I hope to convince the reader that the core of correlationism is transcendentalism.

  5. Shuttle Spacelab Core Equipment Freezer

    Science.gov (United States)

    Copeland, R. J.

    1977-01-01

    This paper describes the preliminary design of a Shuttle Spacelab Core Equipment Freezer. The unit will provide the capability to freeze and store many experiment specimens. Two models of the unit are planned. One model provides storage at -70 C; the other model will provide -70 C storage, a freeze dry capability, storage at a selectable temperature in the range of 0 C to -70 C, and means of maintaining close temperature tolerances. In addition an exchanger loop will be available at 4 C for cooling of a centrifuge and a remote storage compartment. A test tube holder, a dish holder and thermal capacitors for rapid freezing of large specimens will also be provided. A Stirling Cycle was selected as the active refrigerator for minimum cost and weight.

  6. Methodology for embedded transport core calculation

    Science.gov (United States)

    Ivanov, Boyan D.

    The progress in the Nuclear Engineering field leads to developing new generations of Nuclear Power Plants (NPP) with complex rector core designs, such as cores loaded partially with mixed-oxide (MOX) fuel, high burn-up loadings, and cores with advanced designs of fuel assemblies and control rods. Such heterogeneous cores introduce challenges for the diffusion theory that has been used for several decades for calculations of the current Pressurized Water Rector (PWR) cores. To address the difficulties the diffusion approximation encounters new core calculation methodologies need to be developed by improving accuracy, while preserving efficiency of the current reactor core calculations. In this thesis, an advanced core calculation methodology is introduced, based on embedded transport calculations. Two different approaches are investigated. The first approach is based on embedded finite element (FEM), simplified P3 approximation (SP3), fuel assembly (FA) homogenization calculation within the framework of the diffusion core calculation with NEM code (Nodal Expansion Method). The second approach involves embedded FA lattice physics eigenvalue calculation based on collision probability method (CPM) again within the framework of the NEM diffusion core calculation. The second approach is superior to the first because most of the uncertainties introduced by the off-line cross-section generation are eliminated.

  7. Analysis of MOX core physics experiments MISTRAL

    Energy Technology Data Exchange (ETDEWEB)

    Ishii, Kazuya [Hitachi, Ltd., Tokyo (Japan); Tatsumi, Masahiro [Nuclear Fuel Industries Ltd., Tokyo (Japan); Kan, Taro [Mitsubishi Heavy Industries Ltd., Tokyo (Japan); Ando, Yoshihira [Toshiba Corp., Tokyo (Japan); Yamamoto, Toru; Iwata, Yutaka; Umano, Takuya; Kanda, Ryoji [Nuclear Power Engineering Corp., Tokyo (Japan)

    2003-03-01

    Nuclear Power Engineering Corporation (NUPEC) has been performing conceptual design studies of high moderation full MOX LWR cores that aim for increasing fissile Pu consumption rate and reducing residual Pu in discharged MOX fuel. As part of these studies, NUPEC, French Atomic Energy Commission (CEA) and their industrial partners implemented an experimental program, MISTRAL, that was devoted to measuring the core physics parameters of such advanced cores. The program consists of one reference UO{sub 2} core, two homogeneous full MOX cores and one full MOX PWR mock-up core that have higher moderation ratio than the conventional lattice. NUPEC has been analyzing the experimental results with the diffusion and the transport calculations by the SRAC code system and the continuous energy Monte Carlo calculations by the MVP code with the common nuclear data file, JENDL-3.2. The calculation results well reproduce the experimental data approximately within the same range of the experimental uncertainty. This indicates that these applied analysis methods give the same accuracy for the UO{sub 2} core and MOX cores, for the different moderation MOX cores, and for the homogeneous and the mock-up MOX cores. (author)

  8. On-line core axial power distribution synthesis method from in-core and ex-core neutron detectors

    Energy Technology Data Exchange (ETDEWEB)

    In, Wang Kee; Cho, Byung Oh [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-10-01

    This document describes the methodology in detail and the synthesis coefficients of the Fourier series expansion and the cubic spline synthesis techniques. A computer program was developed to generate the synthesis coefficients and the core power distribution. For the illustration, various axial power shapes for YGN 3 Cycle 1 and SMART were synthesized using the simulated in-core and/or ex-core detector signals. The results of this study will be useful to select the best synthesis method for the SMART core monitoring and protection systems and to evaluate the accuracy of the synthesized power shape. 4 refs., 13 figs., 5 tabs. (Author)

  9. Synchronizing ice cores from the Renland and Agassiz ice caps to the Greenland Ice Core Chronology

    DEFF Research Database (Denmark)

    Vinther, Bo Møllesøe; Clausen, Henrik Brink; Fischer, D. A.

    2008-01-01

    Four ice cores from the Agassiz ice cap in the Canadian high arctic and one ice core from the Renland ice cap in eastern Greenland have been synchronized to the Greenland Ice Core Chronology 2005 (GICC05) which is based on annual layer counts in the DYE-3, GRIP and NGRIP ice cores. Volcanic....... Annual layer thicknesses in the Agassiz ice cores point to a well-developed Raymond bump in the Agassiz ice cap....... reference horizons, seen in electrical conductivity measurements (ECM) have been used to carry out the synchronization throughout the Holocene. The Agassiz ice cores have been matched to the NGRIP ice core ECM signal, while the Renland core has been matched to the GRIP ice core ECM signal, thus tying...

  10. Progressive Curation of IODP Core Material at Kochi Core Center, Japan

    Science.gov (United States)

    Gupta, L. P.; Hisamitsu, T.; Ahagon, N.; Kuramoto, T.; Tokuyama, H.; Kinoshita, M.

    2014-12-01

    Kochi Core Center (KCC) is one of the 3 IODP core repositories in the world, and is in-charge of curating core materials collected/to be collected from most of the Indian Ocean, west Pacific Ocean and Bering Sea. Curation of IODP core material in the KCC began in 2007 as it started receiving 83 km of Legacy cores from the other IODP core repositories. Since then the KCC has not only maintained curatorial standards of the IODP, but also added many services for convenience of the IODP researchers that include curation of cuttings and deep frozen aliquots of cores, open access to logging equipment in the KCC for core measurements, virtual core library to provide quick online access to 3-D XCT images of the cores collected by the D/V Chikyu, online summary of the cores being curated in the KCC, and up-to-date online images of working half to show status of samples available for prospective users. With its existing stock of 104 km of the IODP & Legacy cores and cores to be recovered from the Indian Ocean in near future by the JOIDES Resolution, and a huge new reefer building with storage capacity of ca. 150 km core becoming part of the KCC this August, the KCC is bound to play a significant role in promoting earth and biogeo-sciences throughout the world, especially in neighboring Asian countries.

  11. Inner Core Rotation from Geomagnetic Westward Drift and a Stationary Spherical Vortex in Earth's Core

    Science.gov (United States)

    Voorhies, C. V.

    1999-01-01

    The idea that geomagnetic westward drift indicates convective leveling of the planetary momentum gradient within Earth's core is pursued in search of a differentially rotating mean state, upon which various oscillations and secular effects might be superimposed. The desired state conforms to roughly spherical boundary conditions, minimizes dissipative interference with convective cooling in the bulk of the core, yet may aide core cooling by depositing heat in the uppermost core and lower mantle. The variational calculus of stationary dissipation applied to a spherical vortex within the core yields an interesting differential rotation profile akin to spherical Couette flow bounded by thin Hartmann layers. Four boundary conditions are required. To concentrate shear induced dissipation near the core-mantle boundary, these are taken to be: (i) no-slip at the core-mantle interface; (ii) geomagnetically estimated bulk westward flow at the base of the core-mantle boundary layer; (iii) no-slip at the inner-outer core interface; and, to describe magnetic locking of the inner core to the deep outer core, (iv) hydrodynamically stress-free at the inner-outer core boundary. By boldly assuming the axial core angular momentum anomaly to be zero, the super-rotation of the inner core is calculated to be at most 1.5 degrees per year.

  12. Core strengthening exercises for low back pain.

    Science.gov (United States)

    Baerga-Varela, Luis; Abréu Ramos, Antonio M

    2006-01-01

    Core strengthening concepts have gained increased popularity in low back rehabilitation. Traditional low back pain rehabilitation is based on a static spine stability model and is composed mostly of modalities, stretching and strengthening exercises. More recent theories, however, include newer concepts of dynamic spinal stability, coordination and neuromuscular control. Core strengthening exercises incorporate these new concepts. Although more research is necessary, the best available evidence suggests that a core strengthening program may be beneficial in reducing pain scores, functional disability and recurrences of acute low back pain episodes. This article reviews "core" anatomy, physiologic models of spinal stability, effects, of low back pain on spinal stability, evidence-based reasoning behind core strengthening and the basic concepts involved in designing a core strengthening program.

  13. Investigating the translation of Earth's inner core

    DEFF Research Database (Denmark)

    Day, Elizabeth A; Cormier, Vernon F; Geballe, Zachary M

    2012-01-01

    The Earth’s inner core provides unique insights into processes that are occurring deep within our Earth today, as well as processes that occurred in the past. The seismic structure of the inner core is complex, and is dominated by anisotropic and isotropic differences between the Eastern......; and a complex hemispherical and radial dependence of anisotropy, attenuation, and scattering in the uppermost inner core. We explore the compatibility of geodynamic models of a translating inner core with seismic observations. Using a relatively simple set of translation models we map the age of material...... times consisting of paths that sample the core near to the proposed hemisphere boundaries. This combination of body wave data samples a range of depths (and consequently ages) in the inner core, and provides an insight into the nature of hemispheres and their compatibility with our predictions...

  14. BN-600 full MOX core benchmark analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Y. I.; Hill, R. N.; Grimm, K.; Rimpault, G.; Newton, T.; Li, Z. H.; Rineiski, A.; Mohanakrishan, P.; Ishikawa, M.; Lee, K. B.; Danilytchev, A.; Stogov, V.; Nuclear Engineering Division; International Atomic Energy Agency; CEA/Cadarache; SERCO Assurance; China Inst. of Atomic Energy; Forschnungszentrum Karlsruhe; Indira Gandhi Centre for Atomic Research; Japan Nuclear Cycle Development Inst.; Korea Atomic Energy Research Inst.; Inst. of Physics and Power Engineering

    2004-01-01

    As a follow-up of the BN-600 hybrid core benchmark, a full MOX core benchmark was performed within the framework of the IAEA co-ordinated research project. Discrepancies between the values of main reactivity coefficients obtained by the participants for the BN-600 full MOX core benchmark appear to be larger than those in the previous hybrid core benchmarks on traditional core configurations. This arises due to uncertainties in the proper modelling of the axial sodium plenum above the core. It was recognized that the sodium density coefficient strongly depends on the core model configuration of interest (hybrid core vs. fully MOX fuelled core with sodium plenum above the core) in conjunction with the calculation method (diffusion vs. transport theory). The effects of the discrepancies revealed between the participants results on the ULOF and UTOP transient behaviours of the BN-600 full MOX core were investigated in simplified transient analyses. Generally the diffusion approximation predicts more benign consequences for the ULOF accident but more hazardous ones for the UTOP accident when compared with the transport theory results. The heterogeneity effect does not have any significant effect on the simulation of the transient. The comparison of the transient analyses results concluded that the fuel Doppler coefficient and the sodium density coefficient are the two most important coefficients in understanding the ULOF transient behaviour. In particular, the uncertainty in evaluating the sodium density coefficient distribution has the largest impact on the description of reactor dynamics. This is because the maximum sodium temperature rise takes place at the top of the core and in the sodium plenum.

  15. Relationship between cycling mechanics and core stability.

    Science.gov (United States)

    Abt, John P; Smoliga, James M; Brick, Matthew J; Jolly, John T; Lephart, Scott M; Fu, Freddie H

    2007-11-01

    Core stability has received considerable attention with regards to functional training in sports. Core stability provides the foundation from which power is generated in cycling. No research has described the relationship between core stability and cycling mechanics of the lower extremity. The purpose of this study was to determine the relationship between cycling mechanics and core stability. Hip, knee, and ankle joint kinematic and pedal force data were collected on 15 competitive cyclists while cycling untethered on a high-speed treadmill. The exhaustive cycling protocol consisted of cycling at 25.8 km x h(-1) while the grade was increased 1% every 3 minutes. A core fatigue workout was performed before the second treadmill test. Total frontal plane knee motion (test 1: 15.1 +/- 6.0 degrees ; test 2: 23.3 +/- 12.5 degrees), sagittal plane knee motion (test 1: 69.9 +/- 4.9 degrees ; test 2: 79.3 +/- 10.1 degrees), and sagittal plane ankle motion (test 1: 29.0 +/- 8.5 degrees ; test 2: 43.0 +/- 22.9 degrees) increased after the core fatigue protocol. No significant differences were demonstrated for pedaling forces. Core fatigue resulted in altered cycling mechanics that might increase the risk of injury because the knee joint is potentially exposed to greater stress. Improved core stability and endurance could promote greater alignment of the lower extremity when riding for extended durations as the core is more resistant to fatigue.

  16. Optimized Cellular Core for Rotorcraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Patz Materials and Technologies proposes to develop a unique structural cellular core material to improve mechanical performance, reduce platform weight and lower...

  17. Material with core-shell structure

    Science.gov (United States)

    Luhrs, Claudia [Rio Rancho, NM; Richard, Monique N [Ann Arbor, MI; Dehne, Aaron [Maumee, OH; Phillips, Jonathan [Rio Rancho, NM; Stamm, Kimber L [Ann Arbor, MI; Fanson, Paul T [Brighton, MI

    2011-11-15

    Disclosed is a material having a composite particle, the composite particle including an outer shell and a core. The core is made from a lithium alloying material and the outer shell has an inner volume that is greater in size than the core of the lithium alloying material. In some instances, the outer mean diameter of the outer shell is less than 500 nanometers and the core occupies between 5 and 99% of the inner volume. In addition, the outer shell can have an average wall thickness of less than 100 nanometers.

  18. Challenges Regarding IP Core Functional Reliability

    Science.gov (United States)

    Berg, Melanie D.; LaBel, Kenneth A.

    2017-01-01

    For many years, intellectual property (IP) cores have been incorporated into field programmable gate array (FPGA) and application specific integrated circuit (ASIC) design flows. However, the usage of large complex IP cores were limited within products that required a high level of reliability. This is no longer the case. IP core insertion has become mainstream including their use in highly reliable products. Due to limited visibility and control, challenges exist when using IP cores and subsequently compromise product reliability. We discuss challenges and suggest potential solutions to critical application IP insertion.

  19. Full MOX core design for advanced PWR

    Energy Technology Data Exchange (ETDEWEB)

    Tochihara, H.; Komano, Y.; Ishida, M.; Mukai, H. [Mitsubishi Heavy Industries, Ltd., Yokohama (Japan)

    1995-12-31

    A full MOX core is an attractive option for large consumption of the recycled plutonium from reprocessed LWR fuel. The feasibility is verified of a full MOX core in a PWR with only small hardware modifications. The advanced PWR has been selected for this purpose. The full MOX core is feasible by increasing the number of control rods and adopting the enriched {sup 10}B in the soluble boron of reactor coolant system. The full MOX cores can be designed using one Pu` content per assembly and without any burnable absorbers. (author) 2 refs.

  20. Core Training and Rehabilitation in Horses.

    Science.gov (United States)

    Clayton, Hilary M

    2016-04-01

    The central body axis or core is a key component in controlling body posture and providing a stable platform for limb movements and generation of locomotor forces. Persistent dysfunction of the deep stabilizing muscles seems to be common in horses indicating a need for core training exercises to restore normal function. Core training should be performed throughout the horse's athletic career to maintain a healthy back and used therapeutically when back pain is identified. This article reviews the structure and function of the equine thoracolumbar spine with special reference to function, dysfunction, conditioning, and rehabilitation of the core musculature. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Design Principles for Synthesizable Processor Cores

    DEFF Research Database (Denmark)

    Schleuniger, Pascal; McKee, Sally A.; Karlsson, Sven

    2012-01-01

    As FPGAs get more competitive, synthesizable processor cores become an attractive choice for embedded computing. Currently popular commercial processor cores do not fully exploit current FPGA architectures. In this paper, we propose general design principles to increase instruction throughput...... on FPGA-based processor cores: first, superpipelining enables higher-frequency system clocks, and second, predicated instructions circumvent costly pipeline stalls due to branches. To evaluate their effects, we develop Tinuso, a processor architecture optimized for FPGA implementation. We demonstrate...... through the use of micro-benchmarks that our principles guide the design of a processor core that improves performance by an average of 38% over a similar Xilinx MicroBlaze configuration....

  2. Nuclear reactor core modelling in multifunctional simulators

    Energy Technology Data Exchange (ETDEWEB)

    Puska, E.K. [VTT Energy, Nuclear Energy, Espoo (Finland)

    1999-06-01

    The thesis concentrates on the development of nuclear reactor core models for the APROS multifunctional simulation environment and the use of the core models in various kinds of applications. The work was started in 1986 as a part of the development of the entire APROS simulation system. The aim was to create core models that would serve in a reliable manner in an interactive, modular and multifunctional simulator/plant analyser environment. One-dimensional and three-dimensional core neutronics models have been developed. Both models have two energy groups and six delayed neutron groups. The three-dimensional finite difference type core model is able to describe both BWR- and PWR-type cores with quadratic fuel assemblies and VVER-type cores with hexagonal fuel assemblies. The one- and three-dimensional core neutronics models can be connected with the homogeneous, the five-equation or the six-equation thermal hydraulic models of APROS. The key feature of APROS is that the same physical models can be used in various applications. The nuclear reactor core models of APROS have been built in such a manner that the same models can be used in simulator and plant analyser applications, as well as in safety analysis. In the APROS environment the user can select the number of flow channels in the three-dimensional reactor core and either the homogeneous, the five- or the six-equation thermal hydraulic model for these channels. The thermal hydraulic model and the number of flow channels have a decisive effect on the calculation time of the three-dimensional core model and thus, at present, these particular selections make the major difference between a safety analysis core model and a training simulator core model. The emphasis on this thesis is on the three-dimensional core model and its capability to analyse symmetric and asymmetric events in the core. The factors affecting the calculation times of various three-dimensional BWR, PWR and WWER-type APROS core models have been

  3. Iron snow in the Martian core?

    Science.gov (United States)

    Davies, Christopher J.; Pommier, Anne

    2018-01-01

    The decline of Mars' global magnetic field some 3.8-4.1 billion years ago is thought to reflect the demise of the dynamo that operated in its liquid core. The dynamo was probably powered by planetary cooling and so its termination is intimately tied to the thermochemical evolution and present-day physical state of the Martian core. Bottom-up growth of a solid inner core, the crystallization regime for Earth's core, has been found to produce a long-lived dynamo leading to the suggestion that the Martian core remains entirely liquid to this day. Motivated by the experimentally-determined increase in the Fe-S liquidus temperature with decreasing pressure at Martian core conditions, we investigate whether Mars' core could crystallize from the top down. We focus on the "iron snow" regime, where newly-formed solid consists of pure Fe and is therefore heavier than the liquid. We derive global energy and entropy equations that describe the long-timescale thermal and magnetic history of the core from a general theory for two-phase, two-component liquid mixtures, assuming that the snow zone is in phase equilibrium and that all solid falls out of the layer and remelts at each timestep. Formation of snow zones occurs for a wide range of interior and thermal properties and depends critically on the initial sulfur concentration, ξ0. Release of gravitational energy and latent heat during growth of the snow zone do not generate sufficient entropy to restart the dynamo unless the snow zone occupies at least 400 km of the core. Snow zones can be 1.5-2 Gyrs old, though thermal stratification of the uppermost core, not included in our model, likely delays onset. Models that match the available magnetic and geodetic constraints have ξ0 ≈ 10% and snow zones that occupy approximately the top 100 km of the present-day Martian core.

  4. Magnetic Properties of Electrical Steel, Power Transformer Core Losses and Core Design Concepts

    OpenAIRE

    Freitag, Christian

    2017-01-01

    The work presented in this PhD-thesis includes the measurement of electrical steel's properties as well as the simulation of power transformer core losses and leads to the investigation of new core design methods.

  5. Magnetic field generation in the lunar core: The role of inner core growth

    Science.gov (United States)

    Scheinberg, A.; Soderlund, K. M.; Schubert, G.

    2015-07-01

    The source of the magnetic field recorded in the lunar crust remains an unresolved problem. The field was most likely produced by a self-sustaining dynamo in the Moon's electrically conducting metal core, but heat flux across the core-mantle boundary was probably insufficient to power a dynamo for the field's currently known duration from 4.2 to 3.56 Ga. Since seismic measurements indicate the existence of a solid iron inner core in addition to a still-liquid iron alloy outer core, inner core solidification and its associated thermochemically driven convection in the outer core could have been responsible for extending the dynamo's lifetime even in the absence of superadiabatic heat flux. Here we present a coupled mantle-core thermal evolution model of the Moon and show that core solidification could explain the onset and shutoff of the lunar dynamo consistent with the global magnetic field inferred from the paleomagnetic record.

  6. Continuous core photographs of sediment cores collected in 2009 offshore from Palos Verdes, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of the data release includes continuous core photographs in bmp format of sediment cores collected in 2009 offshore of Palos Verdes, California. It is one...

  7. Core Concepts in Introductory Physical Geography.

    Science.gov (United States)

    Bacon, Robert S.; Green, Jerry E.

    1981-01-01

    An analysis of 14 introductory physical geography textbooks yielded 121 core concepts (basic concepts appearing in 7-10 books). The authors suggest that the trend toward overspecialization in introductory geography classes can be reversed if teachers agree to stress core concepts and their relationships to geography as a whole. (AM)

  8. Moving core beam energy absorber and converter

    Science.gov (United States)

    Degtiarenko, Pavel V.

    2012-12-18

    A method and apparatus for the prevention of overheating of laser or particle beam impact zones through the use of a moving-in-the-coolant-flow arrangement for the energy absorbing core of the device. Moving of the core spreads the energy deposition in it in 1, 2, or 3 dimensions, thus increasing the effective cooling area of the device.

  9. Observations of exotic inner core waves

    NARCIS (Netherlands)

    Waszek, Lauren; Deuss, A.F.

    2015-01-01

    The seismic structure of Earth’s inner core is highly complex, displaying strong anisotropy and further regional variations. However, few seismic waves are sensitive to the inner core and fundamental questions regarding the origin of the observed seismic features remain unanswered. Thus, new

  10. Common Core in the Real World

    Science.gov (United States)

    Hess, Frederick M.; McShane, Michael Q.

    2013-01-01

    There are at least four key places where the Common Core intersects with current efforts to improve education in the United States--testing, professional development, expectations, and accountability. Understanding them can help educators, parents, and policymakers maximize the chance that the Common Core is helpful to these efforts and, perhaps…

  11. UV Defined Nanoporous Liquid Core Waveguides

    DEFF Research Database (Denmark)

    Christiansen, Mads Brøkner; Gopalakrishnan, Nimi; Ndoni, Sokol

    2011-01-01

    Nanoporous liquid core waveguides, where both core and cladding are made from the same material, are presented. The nanoporous polymer used is intrinsically hydrophobic, but selective UV exposure enables it to infiltrate with an aqueous solution, thus raising the refractive index from 1.26 to 1...

  12. Review of oil water core annular flow

    Energy Technology Data Exchange (ETDEWEB)

    Ghosh, S.; Mandal, T.K.; Das, G. [Department of Chemical Engineering, Indian Institute of Technology, Kharagpur 721302 (India); Das, P.K. [Department of Mechanical Engineering, Indian Institute of Technology, Kharagpur 721302 (India)

    2009-10-15

    The emerging energy efficient technology in the field of high viscous oil transportation is water-lubricated transport of heavy oil, known as core annular flow or CAF. This paper provides a brief review of the past studies on oil-water core annular flows - including studies on hydrodynamics as well as stability of flow. (author)

  13. Reinventing the Core: Community, Dialogue, and Change

    Science.gov (United States)

    Pittendrigh, Adele

    2007-01-01

    This article examines a six-year process of reforming the core curriculum at a midsize public research university, showing how a seminar for first-year students, a lengthy campus-wide dialogue, and a multidisciplinary community of faculty produced a new core curriculum focused on inquiry, communication, and undergraduate research. (Contains 1…

  14. Time: Assessing Understanding of Core Ideas

    Science.gov (United States)

    Thomas, Margaret; McDonough, Andrea; Clarkson, Philip; Clarke, Doug

    2016-01-01

    Although an understanding of time is crucial in our society, curriculum documents have an undue emphasis on reading time and little emphasis on core underlying ideas. Given this context, a one-to-one assessment interview, based on a new framework, was developed and administered to investigate students' understanding of core ideas undergirding the…

  15. Reinventing the Platform Core Through Acquisition

    DEFF Research Database (Denmark)

    Toppenberg, Gustav; Henningsson, Stefan; Eaton, Ben

    2016-01-01

    Digital platform leaders need to continuously innovate the platform core to drive the technological trajectory of the overall architecture and business system, of which the platform is a core element. This papers analyses the potential of and challenges to completing this task through the acquisi...

  16. Development of core design technology for LMR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin; Kim Young In; Kim, Young Il; Kim, Y. G.; Kim, S. J.; Song, H.; Kim, T. K.; Kim, W. S.; Hwang, W.; Lee, B. O.; Park, C. K.; Joo, H. K.; Yoo, J. W.; Kang, H. Y.; Park, W. S

    2000-05-01

    For the development of KALIMER (150 MWe) core conceptual design, design evolution and optimization for improved economics and safety enhancement was performed in the uranium metallic fueled equilibrium core design which uses U-Zr binary fuel not in excess of 20 percent enrichment. Utilizing results of the uranium ,metallic fueled core design, the breeder equilibrium core design with breeding ratio being over 1.1 was developed. In addition, utilizing LMR's excellent neutron economy, various core concepts for minor actinide burnup, inherent safety, economics and non-proliferation were realized and its optimization studies were performed. A code system for the LMR core conceptual design has been established through the implementation of needed functions into the existing codes and development of codes. To improve the accuracy of the core design, a multi-dimensional nodal transport code SOLTRAN, a three-dimensional transient code analysis code STEP, MATRA-LMR and ASSY-P for T/H analysis are under development. Through the automation of design calculations for efficient core design, an input generator and several interface codes have been developed. (author)

  17. The Core-Collapse Supernova Explosion Mechanism

    Science.gov (United States)

    Müller, Bernhard

    2017-11-01

    The explosion mechanism of core-collapse supernovae is a long-standing problem in stellar astrophysics. We briefly outline the main contenders for a solution and review recent efforts to model core-collapse supernova explosions by means of multi-dimensional simulations. Focusing on the neutrino-driven mechanism, we summarize currents efforts to predict supernova explosion and remnant properties.

  18. Go Figure: Math and the Common Core

    Science.gov (United States)

    Burns, Marilyn

    2013-01-01

    In this article about the Common Core State Standards and mathematics, the author wanted to point out what's familiar in these standards and to give teachers clear access to what's different about them. She wanted to emphasize what has made her passionate about the Common Core standards--which is their two-part structure: Standards for…

  19. The Core Journal Concept in Black Studies

    Science.gov (United States)

    Weissinger, Thomas

    2010-01-01

    Black Studies scholars have shown interest in the core journal concept. Indeed, the idea of core journals for the study of the Black experience has changed several times since 1940. While Black Studies scholars are citing Black Studies journals with frequency, they also cite traditional disciplinary journals a great deal of the time. However,…

  20. The modelling of infrared dark cloud cores

    NARCIS (Netherlands)

    Ormel, CW; Shipman, RF; Ossenkopf, [No Value; Helmich, FP

    This paper presents results from modelling 450 mu m and 850 mu m continuum and HCO+ line observations of three distinct cores of an infrared dark cloud (IRDC) directed toward the W51 GMC. In the sub-mm continuum these cores appear as bright, isolated emission features. One of them coincides with the

  1. Lateral restraint assembly for reactor core

    Science.gov (United States)

    Gorholt, Wilhelm; Luci, Raymond K.

    1986-01-01

    A restraint assembly for use in restraining lateral movement of a reactor core relative to a reactor vessel wherein a plurality of restraint assemblies are interposed between the reactor core and the reactor vessel in circumferentially spaced relation about the core. Each lateral restraint assembly includes a face plate urged against the outer periphery of the core by a plurality of compression springs which enable radial preloading of outer reflector blocks about the core and resist low-level lateral motion of the core. A fixed radial key member cooperates with each face plate in a manner enabling vertical movement of the face plate relative to the key member but restraining movement of the face plate transverse to the key member in a plane transverse to the center axis of the core. In this manner, the key members which have their axes transverse to or subtending acute angles with the direction of a high energy force tending to move the core laterally relative to the reactor vessel restrain such lateral movement.

  2. Kinematically Decoupled Cores in Dwarf (Elliptical) Galaxies

    NARCIS (Netherlands)

    Toloba, E.; Peletier, R. F.; Guhathakurta, P.; van de Ven, G.; Boissier, S.; Boselli, A.; Brok, M. d.; Falcón-Barroso, J.; Hensler, G.; Janz, J.; Laurikainen, E.; Lisker, T.; Paudel, S.; Ryś, A.; Salo, H.

    An overview is given of what we know about the frequency of kinematically decoupled cores in dwarf elliptical galaxies. New observations show that kinematically decoupled cores happen just as often in dwarf elliptical as in ordinary early-type galaxies. This has important consequences for the

  3. Core-annular flow through a horizontal pipe : Hydrodynamic counterbalancing of buoyancy force on core

    NARCIS (Netherlands)

    Ooms, G.; Vuik, C.; Poesio, P.

    2007-01-01

    A theoretical investigation has been made of core-annular flow: the flow of a high-viscosity liquid core surrounded by a low-viscosity liquid annular layer through a horizontal pipe. Special attention is paid to the question of how the buoyancy force on the core, caused by a density difference

  4. Beyond the Core: Peer Observation Brings Common Core to Vocational and Electives Classes

    Science.gov (United States)

    Thurber Rasmussen, Harriette

    2014-01-01

    This article describes how a Washington State School District increased professional learning around the Common Core State Standards. The challenge was how to establish a way for career and technical education and electives teachers to learn and apply Common Core in their classes. Weaving Common Core literacy standards into vocational and…

  5. The EPOS Integrated Core Services

    Science.gov (United States)

    Jeffery, Keith; Michelini, Alberto; Bailo, Daniele

    2013-04-01

    EPOS also including other work packages in EPOS such as those concerned with legalistics and financing; (c) a prototype based on the woodman architecture in one domain (seismology) to provide assurance that the architecture is valid. The key aspect is the metadata catalog. In one dimension this is described in 3 levels: (1) discovery metadata using well-known and commonly used standards such as DC (Dublin Core) to enable users (via an intelligent user interface) to search for objects within the EPOS environment relevant to their needs; (2) contextual metadata providing the context of the object described in the catalog to enable a user or the system to determine the relevance of the discovered object(s) to their requirement - the context includes projects, funding, organisations involved, persons involved, related publications, facilities, equipment etc and utilises CERIF (Common European Research Information Format) see www.eurocris.org ; (3) detailed metadata which is specific to a domain or to a particular object and includes the schema describing the object to processing software. The other dimension of the metadata concerns the objects described. These are classified into users, services (including software), data and resources (computing, data storage, instruments and scientific equipment). The core services include not only user access to data, software, services, equipment and associated processing but also facilities for interaction and cooperative working between users and storage of history and experience. EPOS will operate a full e-Science environment including metadata and persistent identifiers.

  6. HBV Core Protein Enhances Cytokine Production

    Directory of Open Access Journals (Sweden)

    Tatsuo Kanda

    2015-09-01

    Full Text Available Hepatitis B virus (HBV infection, a cause of hepatocellular carcinoma (HCC, remains a serious global health concern. HCC development and human hepatocarcinogenesis are associated with hepatic inflammation caused by host interferons and cytokines. This article focused on the association between the HBV core protein, which is one of the HBV-encoding proteins, and cytokine production. The HBV core protein induced the production of interferons and cytokines in human hepatoma cells and in a mouse model. These factors may be responsible for persistent HBV infection and hepatocarcinogenesis. Inhibitors of programmed death (PD-1 and HBV core and therapeutic vaccines including HBV core might be useful for the treatment of patients with chronic HBV infection. Inhibitors of HBV core, which is important for hepatic inflammation, could be helpful in preventing the progression of liver diseases in HBV-infected patients.

  7. Core design and fuel management studies

    Energy Technology Data Exchange (ETDEWEB)

    Min, Byung Joo [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Chan, P. [Atomic Energy of Canada Ltd., Chalk River, ON (Canada)

    1997-06-01

    The design target for the CANDU 9 requires a 20% increase in electrical power output from an existing 480-channel CANDU core. Assuming a net electrical output of 861 MW(e) for a natural uranium fuelled Bruce-B/Darlington reactor in a warm water site, the net electrical output of the reference CANDU 9 reactor would be 1033 MW(e). This report documents the result of the physics studies for the design of the CANDU 9 480/SEU core. The results of the core design and fuel management studies of the CANDU 9 480/SEU reactor indicated that up to 1033 MW(e) output can be achieved in a 480-channel CANDU core by using SEU core can easily be maintained indefinitely using an automated refuelling program. Fuel performance evaluation based on the data of the 500 FPDs refuelling simulation concluded that SEU fuel failure is not expected. (author). 2 tabs., 38 figs., 5 refs.

  8. Core of communities in bipartite networks

    Science.gov (United States)

    Bongiorno, Christian; London, András; Miccichè, Salvatore; Mantegna, Rosario N.

    2017-08-01

    We use the information present in a bipartite network to detect cores of communities of each set of the bipartite system. Cores of communities are found by investigating statistically validated projected networks obtained using information present in the bipartite network. Cores of communities are highly informative and robust with respect to the presence of errors or missing entries in the bipartite network. We assess the statistical robustness of cores by investigating an artificial benchmark network, the coauthorship network, and the actor-movie network. The accuracy and precision of the partition obtained with respect to the reference partition are measured in terms of the adjusted Rand index and the adjusted Wallace index, respectively. The detection of cores is highly precise, although the accuracy of the methodology can be limited in some cases.

  9. FAST FOSSIL ROTATION OF NEUTRON STAR CORES

    Energy Technology Data Exchange (ETDEWEB)

    Melatos, A., E-mail: amelatos@unimelb.edu.au [School of Physics, University of Melbourne, Parkville, VIC 3010 (Australia)

    2012-12-10

    It is argued that the superfluid core of a neutron star super-rotates relative to the crust, because stratification prevents the core from responding to the electromagnetic braking torque, until the relevant dissipative (viscous or Eddington-Sweet) timescale, which can exceed {approx}10{sup 3} yr and is much longer than the Ekman timescale, has elapsed. Hence, in some young pulsars, the rotation of the core today is a fossil record of its rotation at birth, provided that magnetic crust-core coupling is inhibited, e.g., by buoyancy, field-line topology, or the presence of uncondensed neutral components in the superfluid. Persistent core super-rotation alters our picture of neutron stars in several ways, allowing for magnetic field generation by ongoing dynamo action and enhanced gravitational wave emission from hydrodynamic instabilities.

  10. Fast Fossil Rotation of Neutron Star Cores

    Science.gov (United States)

    Melatos, A.

    2012-12-01

    It is argued that the superfluid core of a neutron star super-rotates relative to the crust, because stratification prevents the core from responding to the electromagnetic braking torque, until the relevant dissipative (viscous or Eddington-Sweet) timescale, which can exceed ~103 yr and is much longer than the Ekman timescale, has elapsed. Hence, in some young pulsars, the rotation of the core today is a fossil record of its rotation at birth, provided that magnetic crust-core coupling is inhibited, e.g., by buoyancy, field-line topology, or the presence of uncondensed neutral components in the superfluid. Persistent core super-rotation alters our picture of neutron stars in several ways, allowing for magnetic field generation by ongoing dynamo action and enhanced gravitational wave emission from hydrodynamic instabilities.

  11. Evidence of Historical Supernovae in Ice Cores

    Science.gov (United States)

    Young, Donna

    2011-05-01

    Within the framework of the U.S. Greenland Ice Core Science Project (GISP2), an ice core, known as the GISP H-Core, was collected in June, 1992 adjacent to the GISP2 summit drill site. The project scientists, Gisela A.M. Dreschhoff and Edward J. Zeller, were interested in dating solar proton events with volcanic eruptions. The GISP2-H 122-meter firn and ice core is a record of 415 years of liquid electrical conductivity (LEC) and nitrate concentrations, spanning the years 1992 at the surface through 1577 at the bottom. At the National Ice Core Laboratory in Denver, Colorado, the core (beneath the 12-meter firn) was sliced into 1.5 cm sections and analyzed. The resulting data set consisted of 7,776 individual analyses. The ultrahigh resolution sampling technique resulted in a time resolution of one week near the surface and one month at depth. The liquid electrical conductivity (LEC) sequence contains signals from a number of known volcanic eruptions and provides a dating system at specific locations along the core. The terrestrial and solar background nitrate records show seasonal and annual variations, respectively. However, major nitrate anomalies within the record do not correspond to any known terrestrial or solar events. There is evidence that these nitrate anomalies could be a record of supernovae events. Cosmic X-rays ionize atmospheric nitrogen, producing excess nitrate that is then deposited in the Polar Regions. The GISP2-H ice core has revealed nitrate anomalies at the times of the Tycho and Kepler supernovae. The Cassiopeia A supernova event may be documented in the core as well. We have developed a classroom activity for high school and college students, in which they examine several lines of evidence in the Greenland ice core, discriminating among nearby and mid-latitude volcanic activity, solar proton events, and supernovae. Students infer the date of the Cassiopeia A supernova.

  12. Core-annular flow through a horizontal pipe: hydrodynamic counterbalancing of buoyancy force on core

    OpenAIRE

    Ooms, G.; Vuik, C.; Poesio, P.

    2008-01-01

    A theoretical investigation has been made of core-annular flow: the flow of a high-viscosity liquid core surrounded by a low-viscosity liquid annular layer through a horizontal pipe. Special attention is paid to the question of how the buoyancy force on the core, caused by a density difference between the core and the annular layer, is counterbalanced. From earlier studies it is known that at the interface between the annular layer and the core waves are present that move with respect to the ...

  13. A study on the recriticality possibilities of fast reactor cores after a hypothetical core meltdown accident

    Energy Technology Data Exchange (ETDEWEB)

    Na, Byung Chan; Han, Do Hee; Kim, Young Cheol

    1997-04-01

    The preliminary and parametric sensitivity study on recriticality risk of fast reactor cores after a hypothetical total core meltdown accident was performed. Only the neutronic aspects of the accident was considered for this study, independent of the accident scenario. Estimation was made for the quantities of molten fuel which must be ejected out of the core in order to assure a sub-critical state. Diverse parameters were examined: molten pool type (homogenized or stratified), fuel temperature, conditions of the reactor core, core size (small or large), and fuel type (oxide, nitride, metal) (author). 7 refs.

  14. The Fuzziness of Giant Planets’ Cores

    Science.gov (United States)

    Helled, Ravit; Stevenson, David

    2017-05-01

    Giant planets are thought to have cores in their deep interiors, and the division into a heavy-element core and hydrogen-helium envelope is applied in both formation and structure models. We show that the primordial internal structure depends on the planetary growth rate, in particular, the ratio of heavy elements accretion to gas accretion. For a wide range of likely conditions, this ratio is in one-to-one correspondence with the resulting post-accretion profile of heavy elements within the planet. This flux ratio depends sensitively on the assumed solid-surface density in the surrounding nebula. We suggest that giant planets’ cores might not be distinct from the envelope and includes some hydrogen and helium, and the deep interior can have a gradual heavy-element structure. Accordingly, Jupiter’s core may not be well defined. Accurate measurements of Jupiter’s gravitational field by Juno could put constraints on Jupiter’s core mass. However, as we suggest here, the definition of Jupiter’s core is complex, and the core’s physical properties (mass, density) depend on the actual definition of the core and on the planet’s growth history.

  15. The Fuzziness of Giant Planets’ Cores

    Energy Technology Data Exchange (ETDEWEB)

    Helled, Ravit [Institute for Computational Science, University of Zurich, Zurich (Switzerland); Stevenson, David [Division of Geological and Planetary Sciences, Caltech, Pasadena, CA (United States)

    2017-05-01

    Giant planets are thought to have cores in their deep interiors, and the division into a heavy-element core and hydrogen–helium envelope is applied in both formation and structure models. We show that the primordial internal structure depends on the planetary growth rate, in particular, the ratio of heavy elements accretion to gas accretion. For a wide range of likely conditions, this ratio is in one-to-one correspondence with the resulting post-accretion profile of heavy elements within the planet. This flux ratio depends sensitively on the assumed solid-surface density in the surrounding nebula. We suggest that giant planets’ cores might not be distinct from the envelope and includes some hydrogen and helium, and the deep interior can have a gradual heavy-element structure. Accordingly, Jupiter’s core may not be well defined. Accurate measurements of Jupiter’s gravitational field by Juno could put constraints on Jupiter’s core mass. However, as we suggest here, the definition of Jupiter’s core is complex, and the core’s physical properties (mass, density) depend on the actual definition of the core and on the planet’s growth history.

  16. Core muscle activity during suspension exercises.

    Science.gov (United States)

    Mok, Nicola W; Yeung, Ella W; Cho, Jeran C; Hui, Samson C; Liu, Kimee C; Pang, Coleman H

    2015-03-01

    Suspension exercise has been advocated as an effective means to improve core stability among healthy individuals and those with musculoskeletal complaints. However, the activity of core muscles during suspension exercises has not been reported. In this study, we investigated the level of activation of core muscles during suspension exercises within young and healthy adults. The study was conducted in a controlled laboratory setting. Surface electromyographic (sEMG) activity of core muscles (rectus abdominis, external oblique, internal oblique/transversus abdominis, and superficial lumbar multifidus) during four suspension workouts (hip abduction in plank, hamstring curl, chest press, and 45° row) was investigated. Muscle activity during a 5-s hold period of the workouts was measured by sEMG and normalized to the individual's maximal voluntary isometric contraction (MVIC). Different levels of muscle activation were observed during the hip abduction in plank, hamstring curl, and chest press. Hip abduction in plank generated the highest activation of most abdominal muscles. The 45° row exercise generated the lowest muscle activation. Among the four workouts investigated, the hip abduction in plank with suspension was found to have the strongest potential strengthening effect on core muscles. Also, suspension training was found to generate relatively high levels of core muscle activation when compared with that among previous studies of core exercises on stable and unstable support surfaces. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  17. Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast.

    Science.gov (United States)

    Stuparevic, Igor; Mosrin-Huaman, Christine; Hervouet-Coste, Nadège; Remenaric, Mateja; Rahmouni, A Rachid

    2013-11-01

    The cotranscriptional mRNA processing and packaging reactions that lead to the formation of export-competent messenger ribonucleoprotein particles (mRNPs) are under the surveillance of quality control steps. Aberrant mRNPs resulting from faulty events are retained in the nucleus with ensuing elimination of their mRNA component. The molecular mechanisms by which the surveillance system recognizes defective mRNPs and stimulates their destruction by the RNA degradation machinery are still not completely elucidated. Using an experimental approach in which mRNP formation in yeast is disturbed by the action of the bacterial Rho helicase, we have shown previously that the targeting of Rho-induced aberrant mRNPs is mediated by Rrp6p, which is recruited cotranscriptionally in association with Nrd1p following Rho action. Here we investigated the specific involvement in this quality control process of different cofactors associated with the nuclear RNA degradation machinery. We show that, in addition to the main hydrolytic action of the exonuclease Rrp6p, the cofactors Rrp47p, Mpp6p as well as the Trf-Air-Mtr4 polyadenylation (TRAMP) components Trf4p, Trf5p, and Air2p contribute significantly by stimulating the degradation process upon their cotranscriptional recruitment. Trf4p and Trf5p are apparently recruited in two distinct TRAMP complexes that both contain Air2p as component. Surprisingly, Rrp47p appears to play an important role in mutual protein stabilization with Rrp6p, which highlights a close association between the two partners. Together, our results provide an integrated view of how different cofactors of the RNA degradation machinery cooperate to target and eliminate aberrant mRNPs.

  18. Cotranscriptional Recruitment of RNA Exosome Cofactors Rrp47p and Mpp6p and Two Distinct Trf-Air-Mtr4 Polyadenylation (TRAMP) Complexes Assists the Exonuclease Rrp6p in the Targeting and Degradation of an Aberrant Messenger Ribonucleoprotein Particle (mRNP) in Yeast*

    Science.gov (United States)

    Stuparevic, Igor; Mosrin-Huaman, Christine; Hervouet-Coste, Nadège; Remenaric, Mateja; Rahmouni, A. Rachid

    2013-01-01

    The cotranscriptional mRNA processing and packaging reactions that lead to the formation of export-competent messenger ribonucleoprotein particles (mRNPs) are under the surveillance of quality control steps. Aberrant mRNPs resulting from faulty events are retained in the nucleus with ensuing elimination of their mRNA component. The molecular mechanisms by which the surveillance system recognizes defective mRNPs and stimulates their destruction by the RNA degradation machinery are still not completely elucidated. Using an experimental approach in which mRNP formation in yeast is disturbed by the action of the bacterial Rho helicase, we have shown previously that the targeting of Rho-induced aberrant mRNPs is mediated by Rrp6p, which is recruited cotranscriptionally in association with Nrd1p following Rho action. Here we investigated the specific involvement in this quality control process of different cofactors associated with the nuclear RNA degradation machinery. We show that, in addition to the main hydrolytic action of the exonuclease Rrp6p, the cofactors Rrp47p, Mpp6p as well as the Trf-Air-Mtr4 polyadenylation (TRAMP) components Trf4p, Trf5p, and Air2p contribute significantly by stimulating the degradation process upon their cotranscriptional recruitment. Trf4p and Trf5p are apparently recruited in two distinct TRAMP complexes that both contain Air2p as component. Surprisingly, Rrp47p appears to play an important role in mutual protein stabilization with Rrp6p, which highlights a close association between the two partners. Together, our results provide an integrated view of how different cofactors of the RNA degradation machinery cooperate to target and eliminate aberrant mRNPs. PMID:24047896

  19. Primordial Stratification of the Earth's Core (Invited)

    Science.gov (United States)

    Hernlund, J. W.; Rubie, D. C.; Labrosse, S. J.

    2013-12-01

    A variety of diverse approaches have been used to assess the formation of Earth's core by silicate-metal equilibration in magma oceans formed by energetic impacts during accretion, all of which invariably yield increasing temperatures and impurity concentrations in the downgoing metal as planetary growth progresses. If one builds the core incrementally with metal equilibrated in magma oceans from the center-up, this gives rise to a gravitationally stratified core with a cool iron-rich central region surrounded by a hot impurity-enriched veneer. The kinetic energy of infalling metal leads to mixing that could moderate such stratification, however, in detail the energetic barriers are difficult to overcome. Regardless of the mechanism of downward metal transport from a magma ocean, the fastest possible descent rate of metal into the core is limited by hard turbulence, for which scaling arguments show that the kinetic energy is much smaller than the expected stabilizing gravitational potential energy. This presents a paradox because the bulk of Earth's present day outer core exhibits density fluctuations of order ppb, apart from stratified regions in the uppermost and lowermost ~100 km. The required degree of mixing seems likely to have been achieved by additional kinetic energy from the direct merging of the cores of large differentiated planetesimal-sized bodies, thus metal transport and merging was not entirely determined by processes such as gravity-driven descent through the mantle from a magma ocean. It is unknown whether the mixing was complete, or whether stratified regions such as the F-layer represent the residue of early stratification. It is possible that Earth's inner core has been growing inside an impurity depleted region of Earth's central core since its birth, which carries implications for the age of the inner core as well as the mechanism of its growth.

  20. Muscle activation of different core exercises.

    Science.gov (United States)

    Oliver, Gretchen D; Dwelly, Priscilla M; Sarantis, Nicholas D; Helmer, Rachael A; Bonacci, Jeffery A

    2010-11-01

    Sport health care professionals are always trying to increase muscle activation while instructing exercises that are functional to the sport performance. However, the traditional core exercises are the ones typically performed. This study examined the muscle activation of the lumbopelvic hip complex during traditional core stability exercises and that of the sports performance movements using the CORE X. Fourteen healthy, college-age men (mean age 20.8 ± 3.9 years; mean height, 177.8 ± 10.9 cm; mean weight, 67.3 ± 9.9 kg) participated. Electromyographic (EMG) data were collected on the following muscles: dominant gluteus maximus, dominant gluteus medius, rectus abdomonis (bilateral), external oblique (bilateral), and multifidis (bilateral). Results revealed a significant difference between the 2 different exercise programs for all muscles investigated except the external obliques (p CORE X showed increased mean muscle activation for the dominant (57.8% maximum voluntary isometric contraction [MVIC]) and nondominant multifidus (56.4% MVIC) and the dominant gluteus maximus (48.3% MVIC) and medius (65.3% MVIC), whereas the traditional core exercises showed greater mean muscle activation for the dominant (45.1% MVIC) and nondominant rectus abdominis (47.4% MVIC) and external oblique (45.8% MVIC and 47.8% MVIC). The investigators were able to determine that while performing movements that mimicked more sports-related activities with the CORE X, there is a greater activation of the core musculature. Coaches, trainers, and athletic trainers should focus on training a core neutral while performing sports-specific movements that can be done with the CORE X.

  1. Oak Ridge National Laboratory Core Competencies

    Energy Technology Data Exchange (ETDEWEB)

    Roberto, J.B.; Anderson, T.D.; Berven, B.A.; Hildebrand, S.G.; Hartman, F.C.; Honea, R.B.; Jones, J.E. Jr.; Moon, R.M. Jr.; Saltmarsh, M.J.; Shelton, R.B. [and others

    1994-12-01

    A core competency is a distinguishing integration of capabilities which enables an organization to deliver mission results. Core competencies represent the collective learning of an organization and provide the capacity to perform present and future missions. Core competencies are distinguishing characteristics which offer comparative advantage and are difficult to reproduce. They exhibit customer focus, mission relevance, and vertical integration from research through applications. They are demonstrable by metrics such as level of investment, uniqueness of facilities and expertise, and national impact. The Oak Ridge National Laboratory (ORNL) has identified four core competencies which satisfy the above criteria. Each core competency represents an annual investment of at least $100M and is characterized by an integration of Laboratory technical foundations in physical, chemical, and materials sciences; biological, environmental, and social sciences; engineering sciences; and computational sciences and informatics. The ability to integrate broad technical foundations to develop and sustain core competencies in support of national R&D goals is a distinguishing strength of the national laboratories. The ORNL core competencies are: 9 Energy Production and End-Use Technologies o Biological and Environmental Sciences and Technology o Advanced Materials Synthesis, Processing, and Characterization & Neutron-Based Science and Technology. The distinguishing characteristics of each ORNL core competency are described. In addition, written material is provided for two emerging competencies: Manufacturing Technologies and Computational Science and Advanced Computing. Distinguishing institutional competencies in the Development and Operation of National Research Facilities, R&D Integration and Partnerships, Technology Transfer, and Science Education are also described. Finally, financial data for the ORNL core competencies are summarized in the appendices.

  2. Spatial Indexing of Datasets for CoreWall: CoreNavigator

    Science.gov (United States)

    Morin, P.; Jenkins, C.; Rao, A.; Kamp, B.; Higgins, S.; Ito, E.; Johnson, A.

    2006-12-01

    Corewall is a community computing facility for logging ice, lake, sediment and hard rock cores. It is described as a Collaborative Interactive Core Analysis Environment, allowing dispersed (even international and ship-side / in-the-field) logging and interpretation on sections of core representing Earth history. Many institutions support Corewall, including NSF. CoreNavigator is a 3D Visual Indexer of core and stratigraphic datasets, necessary because GIS systems available to researchers do not adequately display the vertical stratigraphic structure, or let users browse at will through the stratigraphy. CoreNavigator including its Google Earth extension, is likely to be a primary point of entry for the community into CoreWall. By a combination of 3D VRML and KML visualization technologies CoreNavigator indexes thousands of cores for user selection leading to a variety of actions. By clicking on visual 3D elements of CoreNavigator, users can obtain tables of integrated ready-to-use data (e.g., from dbSEABED, see web). They can also drill down into the original field notes, core photos, equipment types, lab analysis files, calibrations, etc. They can launch applications including the Corelyzer part of Corewall. [CoreNavigator 3D VRML displays are also editable and publishable, and can have seismic, oceanography, culture objects inserted. In the Geowall environment they are a resource for education.] CoreNavigator will be demonstrated as part of Corewall. By adopting a single spatial - global approach in this way to all types of cored stratigraphic data - ice, sediment, rock sea and lake - researchers will be able to transfer their enquiries and validation exercises in questions of environmental change, across the whole Earth surface.

  3. Impact response of balsa core sandwiches

    Directory of Open Access Journals (Sweden)

    Nurdane Mortas

    2014-10-01

    Full Text Available The benefits of resins nano-enhanced on the impact response of sandwich composites made by fiber glass/epoxy skins and balsa wood core were studied. Afterwards, the influence of the core's discontinuity was analyzed in terms of impact strength. For better dispersion and interface adhesion matrix/clay nanoclays were previously subjected to a silane treatment appropriate to the epoxy resin. Resins enhanced by nanoclays promote higher maximum impact loads, lower displacements and the best performance in terms of elastic recuperation. The core's discontinuity decreases the impact strength, but the resin enhanced by nanoclays promotes significant benefits.

  4. Hollow Core, Whispering Gallery Resonator Sensors

    CERN Document Server

    Ward, Jonathan M; Chormaic, Síle Nic

    2014-01-01

    A review of hollow core whispering gallery resonators (WGRs)is given. After a short introduction to the topic of whispering gallery resonators we provide a description of whispering gallery modes in hollow or liquid core WGRs. Next, whispering gallery mode (WGM) sensing mechanisms are outlined and some fabrication methods for microbubbles, microcapillaries and other tubular WGM devices are discussed. We then focus on the most common applications of hollow core WGRs, namely refractive index and temperature sensing, gas sensing, force sensing, biosensing, and lasing. The review highlights some of the key papers in this field and gives the reader a general overview of the current state-of-the-art.

  5. Petrographic Analysis of Cores from Plant 42

    Science.gov (United States)

    2016-10-01

    ER D C TR -X X- D R AF T Petrographic Analysis of Cores from Plant 42 E n gi n ee r R es ea rc h a n d D ev el op m en t C en te r...Air Force Plant 42, were logged in as CMB No. 160143-1 to 160143-13, were subjected to an in-depth analysis consisting of visual and petrographic...Struc- tures Laboratory was requested to perform an analysis on concrete core samples extracted from Air Force Plant 42. A total of 13 cores were

  6. Preliminaries on core image analysis using fault drilling samples; Core image kaiseki kotohajime (danso kussaku core kaisekirei)

    Energy Technology Data Exchange (ETDEWEB)

    Miyazaki, T.; Ito, H. [Geological Survey of Japan, Tsukuba (Japan)

    1996-05-01

    This paper introduces examples of image data analysis on fault drilling samples. The paper describes the following matters: core samples used in the analysis are those obtained from wells drilled piercing the Nojima fault which has moved in the Hygoken-Nanbu Earthquake; the CORESCAN system made by DMT Corporation, Germany, used in acquiring the image data consists of a CCD camera, a light source and core rotation mechanism, and a personal computer, its resolution being about 5 pixels/mm in both axial and circumferential directions, and 24-bit full color; with respect to the opening fractures in core samples collected by using a constant azimuth coring, it was possible to derive values of the opening width, inclination angle, and travel from the image data by using a commercially available software for the personal computer; and comparison of this core image with the BHTV record and the hydrophone VSP record (travel and inclination obtained from the BHTV record agree well with those obtained from the core image). 4 refs., 4 figs.

  7. Massive Quiescent Cores in Orion: Dichotomy in the Dynamical Status of Cores

    Science.gov (United States)

    Velusamy, Thangasamy; Goldsmith, P. F.; Li, D.; Langer, W. D.; Pineda, J. L.; Peng, R.

    2009-01-01

    To study the evolution of high mass cores we have searched for evidence of collapse motions in a large sample of starless cores in the Orion molecular cloud. We used the Caltech Submillimeter Observatory telescope to obtain spectra of the optically thin (H13CO+) and optically thick (HCO+) high density tracer molecules in 27 cores with masses > 1 MO. The red- and blue-asymmetries seen in the line profiles of the optically thick line with respect to the optically thin line indicate that 2/3 of these cores are not static and we interpret these as evidence for inward or outward motions in 19 cores. We present RATRAN radiative transfer models of these cores that support the interpretation of inward and outward motion consistent with the observed spectral asymmetries. Thus we detect infall (inward motions) in 9 cores and outward motions for 10 cores, suggesting a dichotomy in the kinematic state in this sample. This population of massive molecular cloud cores is in general likely to be dynamic, out-of-equilibrium structures, rather than quasi-hydro/magneto-static structures. Our results provide an important observational constraint on the fraction of collapsing (inward motions) versus non-collapsing (re-expanding) cores for comparison with model simulations. This work was performed by the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration. Research at the Caltech Submillimeter Observatory is supported by NSF grant AST-0229008.

  8. Assessment of the HPLWR thermal core design

    Energy Technology Data Exchange (ETDEWEB)

    Schulenberg, T. [Karlsruhe Inst. of Tech., Karlsruhe (Germany); Maraczy, C. [Hungarian Academy of Sciences KFKI, Budapest (Hungary); Bernnat, W.; Starflinger, J. [Univ. of Stuttgart, IKE (Germany)

    2011-07-01

    The core design concept of the High Performance Light Water Reactor features a thermal neutron spectrum, provided by additional moderator water in water boxes and in gaps between assembly boxes, and a heat-up of the coolant in three steps from 280{sup o}C to 500{sup o}C. Intermediate coolant mixing has been foreseen by mixing chambers underneath and above the core to overcome the hot channel issue of a core design with a large enthalpy rise. The paper summarizes the various analyses performed within the project HPLWR-Phase 2 with respect to this core design and assesses how far the initial design target has been met. (author)

  9. NICHD Microscopy and Imaging Core (MIC)

    Data.gov (United States)

    Federal Laboratory Consortium — The NICHD Microscopy and Imaging Core (MIC) is designed as a multi-user research facility providing training and instrumentation for high resolution microscopy and...

  10. Bioinformatics and Computational Core Technology Center

    Data.gov (United States)

    Federal Laboratory Consortium — SERVICES PROVIDED BY THE COMPUTER CORE FACILITYEvaluation, purchase, set up, and maintenance of the computer hardware and network for the 170 users in the research...

  11. Inquiry, New Literacies, and the Common Core

    Science.gov (United States)

    Stegman, Bridget

    2014-01-01

    For 21st century learning, students need to be well versed in techniques for inquiry using new literacies. Developing these skills also will meet the rigorous expectations of the Common Core State Standards.

  12. Pilates: Build Strength in Your Core Muscles

    Science.gov (United States)

    ... in the 1920s. A Pilates routine generally includes exercises that promote core strength and stability, muscle control and endurance, including exercises that stress proper posture and movement patterns and ...

  13. Core inflation indicators for Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Alkhareif Ryadh M.

    2015-01-01

    Full Text Available This paper constructs and analyzes core inflation indicators for Saudi Arabia for the period of March 2012 to May 2014 using two alternative approaches: the exclusion method (ex food and housing/rent and the statistical method. The findings of the analysis suggest that the ex food and housing/ rent inflation is more volatile than the overall CPI inflation over the sample period. In contrast, the statistical core inflation is relatively more stable and less volatile. Moreover, the ex food and housing/rent inflation is only weakly correlated with headline inflation, whereas the statistical core inflation exhibits a stronger correlation. This combination of lower volatility and higher correlation with headline inflation makes the statistical method a much better choice for policymakers. From a monetary policy standpoint, using a bundle of core inflation measures, including both properly constructed exclusion and statistical methods, is more desirable, especially when variation across measures is widespread, as is the case in Saudi Arabia.

  14. Data from Devils Hole Core DH-11

    Science.gov (United States)

    Landwehr, Jurate Maciunas; Coplen, T.B.; Ludwig, K. R.; Winograd, I.J.; Riggs, A.C.

    1997-01-01

    This report presents the stable isotope values measured in Devils Hole Core DH-11 and interpolated ages at the depth the samples were taken, as analyzed in a recent publication by Winograd and others (1997).

  15. Perception Management: A Core IO Capability

    National Research Council Canada - National Science Library

    Zaman, Khyber

    2007-01-01

    This thesis postulates that in today's media environment, with adversaries skillfully using propaganda to skirt nations' resolve, Perception Management is key to military success and should be an Information Operations (IO) Core Capability...

  16. Chamber Core Structures for Fairing Acoustic Mitigation

    National Research Council Canada - National Science Library

    Lane, Steven A; Henderson, Kyle; Williams, Andrew; Ardelean, Emil

    2007-01-01

    .... A composite chamber core fairing consists of many axial tubes sandwiched between face sheets, tubes that can be used as acoustic dampers to reduce low-frequency interior noise with virtually no added mass...

  17. Wire core reactor for nuclear thermal propulsion

    Science.gov (United States)

    Harty, Richard B.; Brengle, Robert G.

    1993-01-01

    Studies have been performed of a compact high-performance nuclear rocket reactor that incorporates a tungsten alloy wire fuel element. This reactor, termed the wire core reactor, can deliver a specific impulse of 1,000 s using an expander cycle and a nozzle expansion ratio of 500 to 1. The core is constructed of layers of 0.8-mm-dia fueled tungsten wires wound over alternate layers of spacer wires, which forms a rugged annular lattice. Hydrogen flow in the core is annular, flowing from inside to outside. In addition to the concepts compact size and good heat transfer, the core has excellent power-flow matching features and can resist vibration and thermal stresses during star-up and shutdown.

  18. Multi-core fiber undersea transmission systems

    DEFF Research Database (Denmark)

    Nooruzzaman, Md; Morioka, Toshio

    2017-01-01

    Various potential architectures of branching units for multi-core fiber undersea transmission systems are presented. It is also investigated how different architectures of branching unit influence the number of fibers and those of inline components....

  19. Core Stabilization Exercise Prescription, Part I

    Science.gov (United States)

    Brumitt, Jason; Matheson, J. W.; Meira, Erik P.

    2013-01-01

    Context: Injury to the low back can cause significant pain and dysfunction, which can affect an athlete’s performance and result in time lost from sport. A common conservative treatment is therapeutic core stabilization exercises, which can address pain and musculoskeletal dysfunction in patients with low back pathology. Evidence Acquisition: MEDLINE and CINAHL were searched (from 1966 to March 2013) to identify relevant research. Keywords and keyword combinations searched included motor control exercise, segmental stabilization, core stabilization, transversus abdominis, multifidi, and low back pain. Results: There are 2 popular rehabilitation strategies to assess core function and promote core stabilization. Each has been developed based on biomechanical models of lumbar segmental stability and observed motor control dysfunction in patients with low back pain. Conclusion: Controversy exists among clinical and research groups as to the optimal strategy for an athlete with low back pain. PMID:24427424

  20. NICHD Biomedical Mass Spectrometry Core Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The NICHD Biomedical Mass Spectrometry Core Facility was created under the auspices of the Office of the Scientific Director to provide high-end mass-spectrometric...

  1. Satcom access in the evolved packet core

    NARCIS (Netherlands)

    Cano, M.D.; Norp, A.H.J.; Popova, M.P.

    2012-01-01

    Satellite communications (Satcom) networks are increasingly integrating with terrestrial communications networks, namely Next Generation Networks (NGN). In the area of NGN the Evolved Packet Core (EPC) is a new network architecture that can support multiple access technologies. When Satcom is

  2. Multiple network interface core apparatus and method

    Science.gov (United States)

    Underwood, Keith D [Albuquerque, NM; Hemmert, Karl Scott [Albuquerque, NM

    2011-04-26

    A network interface controller and network interface control method comprising providing a single integrated circuit as a network interface controller and employing a plurality of network interface cores on the single integrated circuit.

  3. Design, synthesis and applications of core-shell, hollow core, and nanorattle multifunctional nanostructures

    Science.gov (United States)

    El-Toni, Ahmed Mohamed; Habila, Mohamed A.; Labis, Joselito Puzon; Alothman, Zeid A.; Alhoshan, Mansour; Elzatahry, Ahmed A.; Zhang, Fan

    2016-01-01

    With the evolution of nanoscience and nanotechnology, studies have been focused on manipulating nanoparticle properties through the control of their size, composition, and morphology. As nanomaterial research has progressed, the foremost focus has gradually shifted from synthesis, morphology control, and characterization of properties to the investigation of function and the utility of integrating these materials and chemical sciences with the physical, biological, and medical fields, which therefore necessitates the development of novel materials that are capable of performing multiple tasks and functions. The construction of multifunctional nanomaterials that integrate two or more functions into a single geometry has been achieved through the surface-coating technique, which created a new class of substances designated as core-shell nanoparticles. Core-shell materials have growing and expanding applications due to the multifunctionality that is achieved through the formation of multiple shells as well as the manipulation of core/shell materials. Moreover, core removal from core-shell-based structures offers excellent opportunities to construct multifunctional hollow core architectures that possess huge storage capacities, low densities, and tunable optical properties. Furthermore, the fabrication of nanomaterials that have the combined properties of a core-shell structure with that of a hollow one has resulted in the creation of a new and important class of substances, known as the rattle core-shell nanoparticles, or nanorattles. The design strategies of these new multifunctional nanostructures (core-shell, hollow core, and nanorattle) are discussed in the first part of this review. In the second part, different synthesis and fabrication approaches for multifunctional core-shell, hollow core-shell and rattle core-shell architectures are highlighted. Finally, in the last part of the article, the versatile and diverse applications of these nanoarchitectures in

  4. Core Muscle Activation in Suspension Training Exercises

    OpenAIRE

    Cugliari, Giovanni; Boccia, Gennaro

    2017-01-01

    Abstract A quantitative observational laboratory study was conducted to characterize and classify core training exercises executed in a suspension modality on the base of muscle activation. In a prospective single-group repeated measures design, seventeen active male participants performed four suspension exercises typically associated with core training (roll-out, bodysaw, pike and knee-tuck). Surface electromyographic signals were recorded from lower and upper parts of rectus abdominis, ext...

  5. Retention Models on Core-Shell Columns.

    Science.gov (United States)

    Jandera, Pavel; Hájek, Tomáš; Růžičková, Marie

    2017-07-13

    A thin, active shell layer on core-shell columns provides high efficiency in HPLC at moderately high pressures. We revisited three models of mobile phase effects on retention for core-shell columns in mixed aqueous-organic mobile phases: linear solvent strength and Snyder-Soczewiński two-parameter models and a three-parameter model. For some compounds, two-parameter models show minor deviations from linearity due to neglect of possible minor retention in pure weak solvent, which is compensated for in the three-parameter model, which does not explicitly assume either the adsorption or the partition retention mechanism in normal- or reversed-phase systems. The model retention equation can be formulated as a function of solute retention factors of nonionic compounds in pure organic solvent and in pure water (or aqueous buffer) and of the volume fraction of an either aqueous or organic solvent component in a two-component mobile phase. With core-shell columns, the impervious solid core does not participate in the retention process. Hence, the thermodynamic retention factors, defined as the ratio of the mass of the analyte mass contained in the stationary phase to its mass in the mobile phase in the column, should not include the particle core volume. The values of the thermodynamic factors are lower than the retention factors determined using a convention including the inert core in the stationary phase. However, both conventions produce correct results if consistently used to predict the effects of changing mobile phase composition on retention. We compared three types of core-shell columns with C18-, phenyl-hexyl-, and biphenyl-bonded phases. The core-shell columns with phenyl-hexyl- and biphenyl-bonded ligands provided lower errors in two-parameter model predictions for alkylbenzenes, phenolic acids, and flavonoid compounds in comparison with C18-bonded ligands.

  6. Impact response of balsa core sandwiches

    OpenAIRE

    Nurdane Mortas; Paulo N.B. Reis; José A.M. Ferreira

    2014-01-01

    The benefits of resins nano-enhanced on the impact response of sandwich composites made by fiber glass/epoxy skins and balsa wood core were studied. Afterwards, the influence of the core's discontinuity was analyzed in terms of impact strength. For better dispersion and interface adhesion matrix/clay nanoclays were previously subjected to a silane treatment appropriate to the epoxy resin. Resins enhanced by nanoclays promote higher maximum impact loads, lower displacements and the...

  7. Distributed Memory Programming on Many-Cores

    DEFF Research Database (Denmark)

    Berthold, Jost; Dieterle, Mischa; Lobachev, Oleg

    2009-01-01

    is tailored to networks of workstations. Recent work has shown that this implementation shows surprisingly competitive performance on many-core machines, compared to dedicated shared-memory implementations of parallel Haskell. In the paper we describe a case study with different Eden divide......-and-conquer skeletons. We analyse their performance comparing example applications implemented using these Eden skeletons against parallel Haskell implementations using shared memory on many-core machines...

  8. Validation of Core Temperature Estimation Algorithm

    Science.gov (United States)

    2016-01-20

    and risk of heat injury. An algorithm for estimating core temperature based on heart rate has been developed by others in order to avoid standard... risk of heat injury. Accepted standards for measuring core temperature include probes in the pulmonary artery, rectum, or esophagus, and an ingestible...temperature estimation from heart rate for first responders wearing different levels of personal protective equipment," Ergonomics , 2015. 8. J.M

  9. Porous-core honeycomb bandgap THz fiber

    DEFF Research Database (Denmark)

    Nielsen, Kristian; Rasmussen, Henrik K.; Jepsen, Peter Uhd

    2011-01-01

    In this Letter we propose a novel (to our knowledge) porous-core honeycomb bandgap design. The holes of the porous core are the same size as the holes in the surrounding cladding, thereby giving the proposed fiber important manufacturing benefits. The fiber is shown to have a 0:35-THz......-wide fundamental bandgap centered at 1:05 THz. The calculated minimum loss of the fiber is 0:25 dB=cm....

  10. Core-Shell Structured Magnetic Ternary Nanocubes

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Lingyan; Wang, Xin; Luo, Jin; Wanjala, Bridgid N.; Wang, Chong M.; Chernova, Natalya; Engelhard, Mark H.; Liu, Yao; Bae, In-Tae; Zhong, Chuan-Jian

    2010-12-01

    While transition metal-doped ferrite nanoparticles constitute an important class of soft magnetic nanomaterials with spinel structures, the ability to control the shape and composition would enable a wide range of applications in homogeneous or heterogeneous reactions such as catalysis and magnetic separation of biomolecules. This report describes novel findings of an investigation of core-shell structured MnZn ferrite nanocubes synthesized in organic solvents by manipulating the reaction temperature and capping agent composition in the absence of the conventionally-used reducing agents. The core-shell structure of the highly-monodispersed nanocubes (~20 nm) are shown to consist of an Fe3O4 core and an (Mn0.5Zn0.5)(Fe0.9, Mn1.1)O4 shell. In comparison with Fe3O4 and other binary ferrite nanoparticles, the core-shell structured nanocubes were shown to display magnetic properties regulated by a combination of the core-shell composition, leading to a higher coercivity (~350 Oe) and field-cool/zero-field-cool characteristics drastically different from many regular MnZn ferrite nanoparticles. The findings are discussed in terms of the unique core-shell composition, the understanding of which has important implication to the exploration of this class of soft magnetic nanomaterials in many potential applications such as magnetic resonance imaging, fuel cells, and batteries.

  11. Photon upconversion in core-shell nanoparticles.

    Science.gov (United States)

    Chen, Xian; Peng, Denfeng; Ju, Qiang; Wang, Feng

    2015-03-21

    Photon upconversion generally results from a series of successive electronic transitions within complex energy levels of lanthanide ions that are embedded in the lattice of a crystalline solid. In conventional lanthanide-doped upconversion nanoparticles, the dopant ions homogeneously distributed in the host lattice are readily accessible to surface quenchers and lose their excitation energy, giving rise to weak and susceptible emissions. Therefore, present studies on upconversion are mainly focused on core-shell nanoparticles comprising spatially confined dopant ions. By doping upconverting lanthanide ions in the interior of a core-shell nanoparticle, the upconversion emission can be substantially enhanced, and the optical integrity of the nanoparticles can be largely preserved. Optically active shells are also frequently employed to impart multiple functionalities to upconversion nanoparticles. Intriguingly, the core-shell design introduces the possibility of constructing novel upconversion nanoparticles by exploiting the energy exchange interactions across the core-shell interface. In this tutorial review, we highlight recent advances in the development of upconversion core-shell nanoparticles, with particular emphasis on the emerging strategies for regulating the interplay of dopant interactions through core-shell nanostructural engineering that leads to unprecedented upconversion properties. The improved control over photon energy conversion will open up new opportunities for biological and energy applications.

  12. Subannual layer variability in Greenland firn cores

    Science.gov (United States)

    Kjær, Helle Astrid; Vallelonga, Paul; Vinther, Bo; Winstrup, Mai; Simonsen, Marius; Maffezzoli, Niccoló; Jensen, Camilla Marie

    2017-04-01

    Ice cores are used to infer information about the past and modern techniques allow for high resolution (CFA) of the ice. Such analysis is often used to inform on annual layers to constrain dating of ice cores, but can also be extended to provide information on sub-annual deposition patterns. In this study we use available high resolution data from multiple shallow cores around Greenland to investigate the seasonality and trends in the most often continuously measured components sodium, insoluble dust, calcium, ammonium and conductivity (or acidity) from 1800 AD to today. We evaluate the similarities and differences between the records and discuss the causes from different sources and transport to deposition and post-deposition effects over differences in measurement set up. Further we add to the array of cores already published with measurements from the newly drilled ReCAP ice core from a coastal ice cap in eastern Greenland and from a shallow core drilled at the high accumulation site at the Greenland South Dome.

  13. Saturation current spikes eliminated in saturable core transformers

    Science.gov (United States)

    Schwarz, F. C.

    1971-01-01

    Unsaturating composite magnetic core transformer, consisting of two separate parallel cores designed so impending core saturation causes signal generation, terminates high current spike in converter primary circuit. Simplified waveform, demonstrates transformer effectiveness in eliminating current spikes.

  14. Development of Toroidal Core Transformers

    Energy Technology Data Exchange (ETDEWEB)

    de Leon, Francisco [New York Univ. (NYU), Brooklyn, NY (United States). Dept. of Electrical and Computer Engineering

    2014-08-01

    The original objective of this project was to design, build and test a few prototypes of single-phase dry-type distribution transformers of 25 kVA, 2.4 kV primary to 120 V transformers using cores made of a continuous steel strip shaped like a doughnut (toroid). At different points during the development of the project, the scope was enhanced to include the more practical case of a 25 kVA transformer for a 13.8 kV primary system voltage. Later, the scope was further expanded to design and build a 50 kVA unit to transformer voltage from 7.62 kV to 2x120 V. This is a common transformer used by Con Edison of New York and they are willing to test it in the field. The project officially started in September 2009 and ended in May 2014. The progress was reported periodically to DOE in eighteen quarterly reports. A Continuation Application was submitted to DOE in June 2010. In May 2011 we have requested a non-cost extension of the project. In December 2011, the Statement of Project Objectives (SOPO) was updated to reflect the real conditions and situation of the project as of 2011. A second Continuation Application was made and funding was approved in 2013 by DOE and the end date was extended to May 2014. The technical challenges that were overcome in this project include: the development of the technology to pass the impulse tests, derive a model for the thermal performance, produce a sound mechanical design, and estimate the inrush current. However, the greatest challenge that we faced during the development of the project was the complications of procuring the necessary parts and materials to build the transformers. The actual manufacturing process is relatively fast, but getting all parts together is a very lengthy process. The main products of this project are two prototypes of toroidal distribution transformers of 7.62 kV (to be used in a 13.8 kV system) to 2x120 V secondary (standard utilization voltage); one is rated at 25 kVA and the other at 50 kVA. The 25 k

  15. Effects of Core-valence and Core-core Correlation On the Line-strength of the Resonance Lines In Li-i and Na-i

    OpenAIRE

    Brage, Tomas; Fischer, C.F.; Jonsson, P

    1994-01-01

    The resonance lines in Li I and Na I both exhibit a puzzling discrepancy between experiment and accurate ab initio calculations. Only results from a semiempirical method, that in principal neglects core-core correlation, agree with the experiments. The agreement with a multiconfiguration Hartree-Fock calculation, including only core-valence correlation, shows that this might be fortuitous. A method for including some core-core correlation is designed and gives results in excellent agreement w...

  16. NEPHTIS: Core depletion validation relying on 2D transport core calculations with the APOLLO2 code

    Energy Technology Data Exchange (ETDEWEB)

    Damian, F.; Raepsaet, X.; Groizard, M.; Poinot, C. [DEN/DM2S/SERMA/LCA, CEA Saclay, 91191 Gif-sur-Yvette Cedex (France)

    2006-07-01

    The CEA, in collaboration with EDF and AREVA-NP, is developing a core modelling tool called NEPHTIS, for Neutronic Process for HTGR Innovating Systems and dedicated at present day to the prismatic block-type HTGR (High Temperature Gas-Cooled Reactors). Due to the lack of usable HTGR experimental results, the confidence in this neutronic computational tool relies essentially on comparisons to reference or best-estimate calculations. In the present analysis, the Aleppo deterministic transport code has been selected as reference for validating core depletion simulations carried out within NEPHTIS. These reference calculations were performed on fully detailed 2D core configurations using the Method of Characteristics. The latter has been validated versus Monte Carlo method for different static core configurations [1], [2] and [3]. All the presented results come from an annular HTGR core loaded with uranium-based fuel (15% enrichment). During the core depletion validation, reactivity, reaction rates distributions and nuclei concentrations have been compared. In addition, the impact of various physical and geometrical parameters such as the core loading (one-through or batch-wise reloading) and the amount of burnable poison has been investigated during the validation phases. The results confirm that NEPHTIS is able to predict the core reactivity with uncertainties of {+-}350 pcm. At the end of the core irradiation, the U-235 consumption is calculated within {+-} 0, 7 % while the plutonium mass discharged from the core is calculated within {+-}1 %. As far as the core power distributions are concerned, small discrepancies ( and < 2.3 %) can be observed on the fuel block-averaged power distribution in the core. (authors)

  17. Top coalitions, common rankings, and semistrict core stability

    OpenAIRE

    Dinko Dimitrov

    2006-01-01

    The top coalition property of Banerjee et al. (2001) and the common ranking property of Farrell and Scotchmer (1988) are sufficient conditions for core stability in hedonic games. We introduce the semistrict core as a stronger stability concept than the core, and show that the top coalition property guarantees the existence of semistrictly core stable coalition structures. Moreover, for each game satisfying the common ranking property, the core and the semistrict core coincide.

  18. ICF Core Sets for rheumatoid arthritis.

    Science.gov (United States)

    Stucki, Gerold; Cieza, Alarcos; Geyh, Szilvia; Battistella, Linamara; Lloyd, Jill; Symmons, Deborah; Kostanjsek, Nenad; Schouten, Jan

    2004-07-01

    To report on the results of the consensus process integrating evidence from preliminary studies to develop the first version of a Comprehensive ICF Core Set and a Brief ICF Core Set for rheumatoid arthritis. A formal decision-making and consensus process integrating evidence gathered from preliminary studies was followed. Preliminary studies included a Delphi exercise, a systematic review, and an empirical data collection. After training in the ICF, and based on these preliminary studies, relevant ICF categories were identified in a formal consensus process by international experts from different backgrounds. The preliminary studies identified a set of 530 ICF categories at the second, third and fourth ICF levels with 203 categories on body functions, 76 on body structures, 188 on activities and participation, and 63 on environmental factors. Seventeen experts from 12 different countries attended the consensus conference on rheumatoid arthritis (7 physicians with at least a specialization in physical and rehabilitation medicine, 7 rheumatologists, one nurse, one occupational therapist, and one physical therapist). Altogether 96 categories (76 second-level and 20 third-, and fourth-level categories) were included in the Comprehensive ICF Core Set with 25 categories from the component body functions, 18 from body structures, 32 from activities and participation, and 21 from environmental factors. The Brief ICF Core Set included a total of 39 second-level categories, with 8 on body functions, 7 on body structures, 14 on activities and participation, and 10 on environmental factors. A formal consensus process integrating evidence and expert opinion based on the ICF framework and classification led to the definition of ICF Core Sets for rheumatoid arthritis. Both the Comprehensive ICF Core Set and the Brief ICF Core Set were defined.

  19. Overview on Hydrate Coring, Handling and Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Jon Burger; Deepak Gupta; Patrick Jacobs; John Shillinglaw

    2003-06-30

    Gas hydrates are crystalline, ice-like compounds of gas and water molecules that are formed under certain thermodynamic conditions. Hydrate deposits occur naturally within ocean sediments just below the sea floor at temperatures and pressures existing below about 500 meters water depth. Gas hydrate is also stable in conjunction with the permafrost in the Arctic. Most marine gas hydrate is formed of microbially generated gas. It binds huge amounts of methane into the sediments. Worldwide, gas hydrate is estimated to hold about 1016 kg of organic carbon in the form of methane (Kvenvolden et al., 1993). Gas hydrate is one of the fossil fuel resources that is yet untapped, but may play a major role in meeting the energy challenge of this century. In June 2002, Westport Technology Center was requested by the Department of Energy (DOE) to prepare a ''Best Practices Manual on Gas Hydrate Coring, Handling and Analysis'' under Award No. DE-FC26-02NT41327. The scope of the task was specifically targeted for coring sediments with hydrates in Alaska, the Gulf of Mexico (GOM) and from the present Ocean Drilling Program (ODP) drillship. The specific subjects under this scope were defined in 3 stages as follows: Stage 1: Collect information on coring sediments with hydrates, core handling, core preservation, sample transportation, analysis of the core, and long term preservation. Stage 2: Provide copies of the first draft to a list of experts and stakeholders designated by DOE. Stage 3: Produce a second draft of the manual with benefit of input from external review for delivery. The manual provides an overview of existing information available in the published literature and reports on coring, analysis, preservation and transport of gas hydrates for laboratory analysis as of June 2003. The manual was delivered as draft version 3 to the DOE Project Manager for distribution in July 2003. This Final Report is provided for records purposes.

  20. Embedded binaries and their dense cores

    Science.gov (United States)

    Sadavoy, Sarah I.; Stahler, Steven W.

    2017-08-01

    We explore the relationship between young, embedded binaries and their parent cores, using observations within the Perseus Molecular Cloud. We combine recently published Very Large Array observations of young stars with core properties obtained from Submillimetre Common-User Bolometer Array 2 observations at 850 μm. Most embedded binary systems are found towards the centres of their parent cores, although several systems have components closer to the core edge. Wide binaries, defined as those systems with physical separations greater than 500 au, show a tendency to be aligned with the long axes of their parent cores, whereas tight binaries show no preferred orientation. We test a number of simple, evolutionary models to account for the observed populations of Class 0 and I sources, both single and binary. In the model that best explains the observations, all stars form initially as wide binaries. These binaries either break up into separate stars or else shrink into tighter orbits. Under the assumption that both stars remain embedded following binary break-up, we find a total star formation rate of 168 Myr-1. Alternatively, one star may be ejected from the dense core due to binary break-up. This latter assumption results in a star formation rate of 247 Myr-1. Both production rates are in satisfactory agreement with current estimates from other studies of Perseus. Future observations should be able to distinguish between these two possibilities. If our model continues to provide a good fit to other star-forming regions, then the mass fraction of dense cores that becomes stars is double what is currently believed.

  1. Himalayan Ice Core Analyses With Snow Algae

    Science.gov (United States)

    Yoshimura, Y.; Kohshima, S.; Takeuchi, N.; Seko, K.; Fujita, K.

    2004-12-01

    Snow algae in a shallow ice core (7 m in length) from the Yala Glacier, Langtang region of Nepal, were examined for potential use in ice core analyses. Ice core samples taken at 5350 m a.s.l. in 1994, contained more than 7 species of snow algae. In a vertical profile of the algal biomass, 11 distinct algal layers were observed. Seasonal observation in 1996 at the coring site indicated most algal growth to occur from late spring to late summer. Pit observation in 1991, 1992 and 1994 indicated algal layer formation to take place annually. Delta 18O, chemical ions (Na+, Cl-, SO42-, and NO3-) and microparticles failed to show any clear seasonal variation, particularly so at depths exceeding 2 m, possibly due to heavy melt-water percolation. Snow algae in the ice core would thus be accurate boundary markers of annual layers in the ice cores of this region. Algal biomass in each annual layer was noted to be quite closely correlated with the following two environmental indices calculated from air temperature and precipitation at Kyangjing (3,920 m a.s.l.), the village nearest the Yala Glacier: estimated mean snow cover thickness (MST) and estimated summer mass balance (SMB) (n = 6, r = -0.975, P snow cover thickness on algal layers, which would be a major determinant of light available for algal growth on the glacier. The algal biomass was also found to be roughly correlated with air temperature (n = 7, r = 0.773, P snow algae. Snow algal biomass in an ice core should prove a good environmental marker for indicating summer mass balance which is important for understanding summer-accumulation-type glaciers in this region.

  2. Theoretical Investigation of Inter-core Crosstalk Properties in Homogeneous Trench-Assisted Multi-Core Fibers

    DEFF Research Database (Denmark)

    Ye, Feihong; Morioka, Toshio; Tu, Jiajing

    2014-01-01

    We derive analytical expressions for inter-core crosstalk, its dependence on core pitch and wavelength in homogeneous trench-assisted multi-core fibers. They are in excellent agreement with numerical simulation results.......We derive analytical expressions for inter-core crosstalk, its dependence on core pitch and wavelength in homogeneous trench-assisted multi-core fibers. They are in excellent agreement with numerical simulation results....

  3. HANARO core channel flow-rate measurement

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Heon Il; Chae, Hee Tae; Im, Don Soon; Kim, Seon Duk [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-06-01

    HANARO core consists of 23 hexagonal flow tubes and 16 cylindrical flow tubes. To get the core flow distribution, we used 6 flow-rate measuring dummy fuel assemblies (instrumented dummy fuel assemblies). The differential pressures were measured and converted to flow-rates using the predetermined relationship between AP and flow-rate for each instrumented dummy fuel assemblies. The flow-rate for the cylindrical flow channels shows +-7% relative errors and that for the hexagonal flow channels shows +-3.5% relative errors. Generally the flow-rates of outer core channels show smaller values compared to those of inner core. The channels near to the core inlet pipe and outlet pipes also show somewhat lower flow-rates. For the lower flow channels, the thermal margin was checked by considering complete linear power histories. From the experimental results, the gap flow-rate was estimated to be 49.4 kg/s (cf. design flow of 50 kg/s). 15 tabs., 9 figs., 10 refs. (Author) .new.

  4. Development of full MOX core in ABWR

    Energy Technology Data Exchange (ETDEWEB)

    Aoyama, Motoo; Bessho, Yasunori; Izutsu, Sadayuki; Uchikawa, Sadao [Hitachi Ltd., Tokyo (Japan)

    1995-10-01

    In the long term plan on the research, development and utilization of nuclear power, the plan of processing the plutonium extracted by reprocessing spent fuel into MOX fuel and utilizing it for light water reactors was shown. According to this plan, it is considered appropriate that the utilization of MOX fuel will be started in the latter half of 1990s in small number of BWRs and PWRs, and it will be expanded flexibly along the plan to about 10 plants by around 2000. The project of verifying a small number of MOX fuel assemblies has been carried out in Japan, and the experience of the design and operation of MOX fuel has been accumulated independently. In addition to this experience, reflecting the knowledge resulted from utilizing MOX fuel for the advanced thermal reactor, Hitachi Ltd. has exerted efforts positively for the research and development toward the full scale use of MOX fuel for BWRs. The core of advanced BWR has the excellent characteristics suitable to the use of Mox fuel, in which plutonium can absorb neutrons more easily than uranium. In ABWRs, the volume ratio of water to fuel was increased. As to the full MOX core of ABWRs, equilibrium core characteristics, the characteristics of initial charge and converted cores, and core management are described. (K.I.).

  5. Managing water addition to a degraded core

    Energy Technology Data Exchange (ETDEWEB)

    Kuan, P.; Hanson, D.J. [EG and G Idaho, Inc., Idaho Falls, ID (United States); Odar, F. [Nuclear Regulatory Commission, Washington, DC (United States)

    1991-12-31

    In this paper we present information that can be used in severe accident management by providing an improved understanding of the effects of water addition to a degraded core. This improved understanding is developed using a diagram showing a sequence of core damage states. Whenever possible, a temperature and a time after accident initiation are estimated for each damage state in the sequence diagram. This diagram can be used to anticipate the evolution of events during an accident. Possible responses of plant instruments are described to identify these damage states and the effects of water addition. The rate and amount of water addition needed (1) to remove energy from the core, (2) to stabilize the core or (3) to not adversely affect the damage progression, are estimated. Analysis of the capability to remove energy from large cohesive and particulate debris beds indicates that these beds may not be stabilized in the core region and they may partially relocate to the lower plenum of the reactor vessel.

  6. THE RIGIDITY OF THE EARTH'S INNER CORE

    Directory of Open Access Journals (Sweden)

    K. E. BULLEN

    1953-06-01

    Full Text Available The purpose of this paper is to examine and assess, in the
    light of recent evidence, the theory lliat the Earth's inner core has
    a significant rigidity.
    The presenee of an inner core in the Earth is revealed from
    observations of the seismie pliase PKP in the « sliadow zone » for
    which the epicentral distance A lies in the range 105" < A < 143".
    Miss I. Lehmann (r in 1936, followed by Gutenberg and Richter (2
    in 1938, atlrihuted these observations to tlie presence of an inner
    core; and Jeffreys (3 in 1939 applied Airy's theory of diffraetion
    near a caustic to sliow that the alternative theory of diffraetion
    round the outer boundary of the centrai core was not capable of
    explaining tlie observations in the shadow zone. The existence of the
    inner core has been fairly generallv accepted sinee tliis ealculation
    of Jeffreys.

  7. Chimeric hepatitis B virus core particles with parts or copies of the hepatitis C virus core protein.

    OpenAIRE

    Yoshikawa, A.; Tanaka, T.; Hoshi, Y.; Kato, N; Tachibana, K; Iizuka, H; Machida, A; Okamoto, H.; Yamasaki, M; Miyakawa, Y

    1993-01-01

    Either parts or multiple copies of the core gene of hepatitis C virus (HCV) were fused to the 3' terminus of the hepatitis B virus (HBV) core gene with 34 codons removed. As many as four copies of HCV core protein (720 amino acids) were fused to the carboxy terminus of truncated HBV core protein (149 amino acids) without preventing the assembly of HBV core particles. Chimeric core particles were sandwiched between monoclonal antibody to HBV core and that to HCV core, thereby indicating that a...

  8. Optimal core acquisition and remanufacturing policies under uncertain core quality fractions

    NARCIS (Netherlands)

    Teunter, Ruud H.; Flapper, Simme Douwe P.

    2011-01-01

    Cores acquired by a remanufacturer are typically highly variable in quality. Even if the expected fractions of the various quality levels are known, then the exact fractions when acquiring cores are still uncertain. Our model incorporates this uncertainty in determining optimal acquisition decisions

  9. Verification of Cell-Homogenized Whole-Core Transport Calculations in Actual PWR Core Geometry

    Energy Technology Data Exchange (ETDEWEB)

    Akio Yamamoto; Masahiro Tatsumi; Tatsuya Kimoto; Shinya Kosaka; Etsuro Saji

    2000-11-12

    In this paper, a cell-homogenized whole-core transport calculation is applied to a pressurized water reactor (PWR) core and its prediction accuracy on reactivity and power distribution is verified in comparison with cell-heterogeneous whole-core transport calculation results obtained by the method of characteristics. Recent progress in common computer hardware promotes continuous improvements on core calculation methods. Among several different approaches, a three-dimensional pin-by-pin (fine-mesh) core calculation is considered as one of the candidates of advanced methods. In general, although the fine-mesh core calculation explicitly treats each individual pin, it still has three approximations: cell-homogenization, low-level transport theory (usually the SPN or the diffusion approximation) and few-group treatment. Therefore, the impact of these approximations on core characteristics should be evaluated to confirm the feasibility of the three-dimensional fine-mesh core calculation method. This paper focuses on two former approximations, and the impact of these approximations is evaluated.

  10. Wavelength-Dependence of Inter-Core Crosstalk in Homogeneous Multi-Core Fibers

    DEFF Research Database (Denmark)

    Ye, Feihong; Saitoh, Kunimasa; Takenaga, Katsuhiro

    2016-01-01

    The wavelength dependence of inter-core crosstalk in homogeneous multi-core fibers (MCFs) is investigated, and the corresponding analytical expressions are derived. The derived analytical expressions can be used to determine the crosstalk at any wavelength necessary for designing future MCF wavel...

  11. Preserving Social Studies as Core Curricula in an Era of Common Core Reform

    Science.gov (United States)

    Denton, David W.; Sink, Cindy

    2015-01-01

    Education reform over the last two decades has changed perceptions of core curricula. Although social studies has traditionally been part of the core, emphasis on standards-based teaching and learning, along with elaborate accountability schemes, is causing unbalanced treatment of subjects. While the research literature indicates teachers are…

  12. Continuous greenhouse gas measurements from ice cores

    DEFF Research Database (Denmark)

    Stowasser, Christopher

    -consuming and labor-intensive. This PhD thesis presents the development of a new method for measurements of greenhouse gas mixing ratios from ice cores based on a melting device of a continuous flow analysis (CFA) system. The coupling to a CFA melting device enables time-efficient measurements of high resolution......Ice cores offer the unique possibility to study the history of past atmospheric greenhouse gases over the last 800,000 years, since past atmospheric air is trapped in bubbles in the ice. Since the 1950s, paleo-scientists have developed a variety of techniques to extract the trapped air from...... individual ice core samples, and to measure the mixing ratio of greenhouse gases such as carbon dioxide, methane and nitrous oxide in the extracted air. The discrete measurements have become highly accurate and reproducible, but require relatively large amounts of ice per measured species and are both time...

  13. From DeepCore to PINGU

    Directory of Open Access Journals (Sweden)

    Yáñez J.P.

    2016-01-01

    Full Text Available Very large volume neutrino telescopes (VLVNTs observe atmospheric neutrinos over a wide energy range (GeV to TeV, after they travel distances as large as the Earth's diameter. DeepCore, the low energy extension of IceCube, has started making meaningful measurements of the neutrino oscillation parameters θ23 and | Δm232| by analyzing the atmospheric flux at energies above 10 GeV. PINGU, a proposed project to lower DeepCore's energy threshold, aims to use the same flux to further increase the precision with which these parameters are known, and eventually determine the sign of Δm232. The latest results from DeepCore, and the planned transition to PINGU, are discussed here.

  14. Core Graduate Courses: A Missed Learning Opportunity?

    CERN Document Server

    Singh, Chandralekha

    2016-01-01

    An important goal of graduate physics core courses is to help students develop expertise in problem solving and improve their reasoning and meta-cognitive skills. We explore the conceptual difficulties of physics graduate students by administering conceptual problems on topics covered in undergraduate physics courses before and after instruction in related first year core graduate courses. Here, we focus on physics graduate students' difficulties manifested by their performance on two qualitative problems involving diagrammatic representation of vector fields. Some graduate students had great difficulty in recognizing whether the diagrams of the vector fields had divergence and/or curl but they had no difficulty computing the divergence and curl of the vector fields mathematically. We also conducted individual discussions with various faculty members who regularly teach first year graduate physics core courses about the goals of these courses and the performance of graduate students on the conceptual problems...

  15. Stretchable inductor with liquid magnetic core

    Science.gov (United States)

    Lazarus, N.; Meyer, C. D.

    2016-03-01

    Adding magnetic materials is a well-established method for improving performance of inductors. However, traditional magnetic cores are rigid and poorly suited for the emerging field of stretchable electronics, where highly deformable inductors are used to wirelessly couple power and data signals. In this work, stretchable inductors are demonstrated based on the use of ferrofluids, magnetic liquids based on distributed magnetic particles, to create a compliant magnetic core. Using a silicone molding technique to create multi-layer fluidic channels, a liquid metal solenoid is fabricated around a ferrofluid channel. An analytical model is developed for the effects of mechanical strain, followed by experimental verification using two different ferrofluids with different permeabilities. Adding ferrofluid was found to increase the unstrained inductance by up to 280% relative to a similar inductor with a non-magnetic silicone core, while retaining the ability to survive uniaxial strains up to 100%.

  16. Geomagnetic Core Field Secular Variation Models

    DEFF Research Database (Denmark)

    Gillet, N.; Lesur, V.; Olsen, Nils

    2010-01-01

    We analyse models describing time changes of the Earth’s core magnetic field (secular variation) covering the historical period (several centuries) and the more recent satellite era (previous decade), and we illustrate how both the information contained in the data and the a priori information...... (regularisation) affect the result of the ill-posed geomagnetic inverse problem. We show how data quality, frequency and selection procedures govern part of the temporal changes in the secular variation norms and spectra, which are sometimes difficult to dissociate from true changes of the core state. We...... in artificial changes in the model norms and spectra. Model users should keep in mind that such features can be mis-interpreted as the signature of physical mechanisms (e.g. diffusion). Finally, we present perspectives concerning core field modelling: imposing dynamical constraints (e.g. by means of data...

  17. Core/shell nanoparticles in biomedical applications.

    Science.gov (United States)

    Chatterjee, Krishnendu; Sarkar, Sreerupa; Jagajjanani Rao, K; Paria, Santanu

    2014-07-01

    Nanoparticles have several exciting applications in different areas and biomedial field is not an exception of that because of their exciting performance in bioimaging, targeted drug and gene delivery, sensors, and so on. It has been found that among several classes of nanoparticles core/shell is most promising for different biomedical applications because of several advantages over simple nanoparticles. This review highlights the development of core/shell nanoparticles-based biomedical research during approximately past two decades. Applications of different types of core/shell nanoparticles are classified in terms of five major aspects such as bioimaging, biosensor, targeted drug delivery, DNA/RNA interaction, and targeted gene delivery. Copyright © 2013 Elsevier B.V. All rights reserved.

  18. Uncertainties in Core Collapse Supernovae Simulations

    Science.gov (United States)

    Duggan, Jefferson; Cunningham, J.; Kuhlmann, S.; Biswas, R.; Kovacs, E.; Spinka, H.

    2013-01-01

    We present the results of a study of selection criteria to identify Type Ia supernovae photometrically in a simulated mixed sample of Type Ia supernovae and core collapse supernovae. The simulated sample is a mockup of the expected results of the Dark Energy Survey (DES) using the supernovae simulation and fitting package of SNANA [Kessler et al. arXiv:0908.4280]. This is an extension of a previous analysis, [Gjergo et al. arXiv:1205.1480], with updated core collapse templates that are used to simulate the supernovae. We have also studied how systematic variations in the input parameters of the core collapse supernovae, such as absolute brightness and brightness smearing, affect the measured purity of the Type Ia supernova sample.

  19. Free core nutation and geomagnetic jerks

    Science.gov (United States)

    Malkin, Z.

    2013-12-01

    Variations in free core nutation (FCN) are associated with different processes in the Earth's fluid core and core-mantle coupling. The same processes are generally caused the variations in the geomagnetic field (GMF) particularly the geomagnetic jerks (GMJs), which are rapid changes in GMF secular variations. Therefore, the joint investigation of variations in FCN and GMF can elucidate the Earth's interior and dynamics. In this paper, we investigated the FCN amplitude and phase variations derived from VLBI observations. Comparison of the epochs of the changes in the FCN amplitude and phase with the epochs of the GMJs indicated that the observed extremes in the FCN amplitude and phase variations were closely related to the GMJ epochs. In particular, the FCN amplitude begins to grow one to three years after the GMJs. Thus, processes that cause GMJs are assumed as sources of FCN excitation.

  20. Core-shell fuel cell electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Adzic, Radoslav; Bliznakov, Stoyan; Vukmirovic, Miomir

    2017-07-25

    Embodiments of the disclosure relate to electrocatalysts. The electrocatalyst may include at least one gas-diffusion layer having a first side and a second side, and particle cores adhered to at least one of the first and second sides of the at least one gas-diffusion layer. The particle cores includes surfaces adhered to the at least one of the first and second sides of the at least one gas-diffusion layer and surfaces not in contact with the at least one gas-diffusion layer. Furthermore, a thin layer of catalytically atoms may be adhered to the surfaces of the particle cores not in contact with the at least one gas-diffusion layer.

  1. Spin wave mediated magnetic vortex core reversal

    Science.gov (United States)

    Stoll, Hermann

    2012-10-01

    The magnetic vortex is the simplest, non-trivial ground state configuration of micron and sub-micron sized soft magnetic thin film platelets and therefore an interesting subject for the study of micro magnetism. Essential progress in the understanding of nonlinear vortex dynamics was achieved when low-field core toggling was discovered by excitation of the gyrotropic eigenmode at sub-GHz frequencies. At frequencies more than an order of magnitude higher vortex state structures possess spin wave eigenmodes arising from the magneto-static interaction. We demonstrated, experimentally and by micromagnetic simulations, that the unidirectional vortex core reversal process also occurs when azimuthal spin wave modes are excited in the multi-GHz frequency range. This finding highlights the importance of spin wave - vortex interaction and boosts vortex core reversal to much higher frequencies, which may offer new routes for GHz spintronics applications.

  2. Arms Trafficking: Aiding and Abetting Core Crimes

    Directory of Open Access Journals (Sweden)

    Sabina Zgaga

    2015-11-01

    Full Text Available The provision of arms for the commission of crimes is one of the typical forms of aiding and abetting. This article discusses arms trafficking as a form of aiding and abetting the commission of core crimes. It opens with a discussion of aiding and abetting as a form of complicity in the Rome Statute and the case law of the International Criminal Court. Furthermore, the article also analyses the regulation of legal arms trafficking in international and European law. Accordingly, the international criminal law further regulates illegal arms trafficking as an international crime and as complicity to core crimes. Therefore, the article first presents arms trafficking as an international crime and subsequently discusses arms trafficking as complicity in core crimes. The article concludes with a discussion on the regulation of arms trafficking in Slovene law, beginning with legal arms trafficking according to the Firearms Act-1 and ending with illegal arms trafficking as a crime.

  3. Feasibility study on ABWR full MOX core

    Energy Technology Data Exchange (ETDEWEB)

    Yagi, Makoto; Nagano, Mamoru; Sakurai, Shungo [Toshiba Corp., Yokohama (Japan)

    1996-12-31

    Mixed-oxide (MOX) fuels will be utilized as reload fuels in some existing commercial boiling water reactors (BWRs) in Japan around the year 2000. The first step MOX fuel is expected to have an average discharge exposure of 33 GWd/t and to be loaded within one-third of all fuel rods in a core. On the other hand, it becomes necessary to minimize the number of MOX fuels and plants utilizing MOX fuel, mainly because of fuel economy, handling, and site inspection costs. Under these situations, it is important to develop higher burnup MOX fuel containing more plutonium and a core with a larger amount of MOX fuel. The purpose of this study is to clarify the feasibility of high-burnup MOX fuel and core through the evaluation of nuclear characteristics.

  4. NEUTRONIC REACTOR FUEL ELEMENT AND CORE SYSTEM

    Science.gov (United States)

    Moore, W.T.

    1958-09-01

    This patent relates to neutronic reactors and in particular to an improved fuel element and a novel reactor core system for facilitating removal of contaminating fission products, as they are fermed, from association with the flssionable fuel, so as to mitigate the interferent effects of such fission products during reactor operation. The fuel elements are comprised of tubular members impervious to fluid and contatning on their interior surfaces a thin layer of fissionable material providing a central void. The core structure is comprised of a plurality of the tubular fuel elements arranged in parallel and a closed manifold connected to their ends. In the reactor the core structure is dispersed in a water moderator and coolant within a pressure vessel, and a means connected to said manifuld is provided for withdrawing and disposing of mobile fission product contamination from the interior of the feel tubes and manifold.

  5. Core-shell fuel cell electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Adzic, Radoslav; Bliznakov, Stoyan; Vukmirovic, Miomir

    2017-12-26

    Embodiments of the disclosure relate to membrane electrode assemblies. The membrane electrode assembly may include at least one gas-diffusion layer having a first side and a second side, and particle cores adhered to at least one of the first and second sides of the at least one gas-diffusion layer. The particle cores includes surfaces adhered to the at least one of the first and second sides of the at least one gas-diffusion layer and surfaces not in contact with the at least one gas-diffusion layer. Furthermore, a thin layer of catalytically atoms may be adhered to the surfaces of the particle cores not in contact with the at least one gas-diffusion layer.

  6. The core regulatory network in human cells.

    Science.gov (United States)

    Kim, Man-Sun; Kim, Dongsan; Kang, Nam Sook; Kim, Jeong-Rae

    2017-03-04

    In order to discover the common characteristics of various cell types in the human body, many researches have been conducted to find the set of genes commonly expressed in various cell types and tissues. However, the functional characteristics of a cell is determined by the complex regulatory relationships among the genes rather than by expressed genes themselves. Therefore, it is more important to identify and analyze a core regulatory network where all regulatory relationship between genes are active across all cell types to uncover the common features of various cell types. Here, based on hundreds of tissue-specific gene regulatory networks constructed by recent genome-wide experimental data, we constructed the core regulatory network. Interestingly, we found that the core regulatory network is organized by simple cascade and has few complex regulations such as feedback or feed-forward loops. Moreover, we discovered that the regulatory links from genes in the core regulatory network to genes in the peripheral regulatory network are much more abundant than the reverse direction links. These results suggest that the core regulatory network locates at the top of regulatory network and plays a role as a 'hub' in terms of information flow, and the information that is common to all cells can be modified to achieve the tissue-specific characteristics through various types of feedback and feed-forward loops in the peripheral regulatory networks. We also found that the genes in the core regulatory network are evolutionary conserved, essential and non-disease, non-druggable genes compared to the peripheral genes. Overall, our study provides an insight into how all human cells share a common function and generate tissue-specific functional traits by transmitting and processing information through regulatory network. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. ICE CHEMISTRY IN STARLESS MOLECULAR CORES

    Energy Technology Data Exchange (ETDEWEB)

    Kalvans, J., E-mail: juris.kalvans@venta.lv [Engineering Research Institute “Ventspils International Radio Astronomy Center” of Ventspils University College, Inzenieru 101, Ventspils, LV-3601 (Latvia)

    2015-06-20

    Starless molecular cores are natural laboratories for interstellar molecular chemistry research. The chemistry of ices in such objects was investigated with a three-phase (gas, surface, and mantle) model. We considered the center part of five starless cores, with their physical conditions derived from observations. The ice chemistry of oxygen, nitrogen, sulfur, and complex organic molecules (COMs) was analyzed. We found that an ice-depth dimension, measured, e.g., in monolayers, is essential for modeling of chemistry in interstellar ices. Particularly, the H{sub 2}O:CO:CO{sub 2}:N{sub 2}:NH{sub 3} ice abundance ratio regulates the production and destruction of minor species. It is suggested that photodesorption during the core-collapse period is responsible for the high abundance of interstellar H{sub 2}O{sub 2} and O{sub 2}H and other species synthesized on the surface. The calculated abundances of COMs in ice were compared to observed gas-phase values. Smaller activation barriers for CO and H{sub 2}CO hydrogenation may help explain the production of a number of COMs. The observed abundance of methyl formate HCOOCH{sub 3} could be reproduced with a 1 kyr, 20 K temperature spike. Possible desorption mechanisms, relevant for COMs, are gas turbulence (ice exposure to interstellar photons) or a weak shock within the cloud core (grain collisions). To reproduce the observed COM abundances with the present 0D model, 1%–10% of ice mass needs to be sublimated. We estimate that the lifetime for starless cores likely does not exceed 1 Myr. Taurus cores are likely to be younger than their counterparts in most other clouds.

  8. Superrotation of Earth’s Inner Core, Extraterrestrial Impacts, and the Effective Viscosity of Outer Core

    Directory of Open Access Journals (Sweden)

    Pirooz Mohazzabi

    2015-01-01

    Full Text Available The recently verified superrotation of Earth’s inner core is examined and a new model is presented which is based on the tidal despinning of the mantle and the viscosity of the outer core. The model also takes into account other damping mechanisms arising from the inner core superrotation such as magnetic and gravitational coupling as well as contribution from eddy viscosity in the outer core. The effective viscosity obtained in this model confirms a previously well constrained value of about 103 Pa s. In addition, the model shows that the currently measured superrotation of the inner core must be almost exactly equal to its asymptotic or steady-state value. The effect of extraterrestrial impacts is also investigated, and it is shown that perturbations due to such impacts can only persist over a short geological time.

  9. Hole fluids for deep ice core drilling

    OpenAIRE

    Talalay, P.G.; Gundestrup, N.S.

    2002-01-01

    This paper is based on the data published in research report of P. G. Talalay and N. S. Gundestrup; Hole fluids for deep ice core drilling : A review. Copenhagen University, Copenhagen, 1999,120p. In the practice of deep ice core drilling only three types of bore-hole fluids have been used : 1) petroleum oil products (fuels or solvents) containing densifier, 2) aqueous ethylene glycol or ethanol solutions, 3) n-butyl acetate. The main parameters of drilling fluids are 1) density and fluid top...

  10. SproutCore web application development

    CERN Document Server

    Keating, Tyler

    2013-01-01

    Written as a practical, step-by-step tutorial, Creating HTML5 Apps with SproutCore is full of engaging examples to help you learn in a practical context.This book is for any person looking to write software for the Web or already writing software for the Web. Whether your background is in web development or in software development, Creating HTML5 Apps with SproutCore will help you expand your skills so that you will be ready to apply the software development principles in the web development space.

  11. Neural simulations on multi-core architectures

    Directory of Open Access Journals (Sweden)

    Hubert Eichner

    2009-07-01

    Full Text Available Neuroscience is witnessing increasing knowledge about the anatomy and electrophysiological properties of neurons and their connectivity, leading to an ever increasing computational complexity of neural simulations. At the same time, a rather radical change in personal computer technology emerges with the establishment of multi-cores: high-density, explicitly parallel processor architectures for both high performance as well as standard desktop computers. This work introduces strategies for the parallelization of biophysically realistic neural simulations based on the compartmental modeling technique and results of such an implementation, with a strong focus on multi-core architectures and automation, i. e. user-transparent load balancing.

  12. EEA core set of indicators. Guide

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This guide provides information on the quality of the 37 indicators in the EEA core set. Its primary role is to support improved implementation of the core set in the EEA, European topic centres and the European environment information and observation network (Eionet). In parallel, it is aimed at helping users outside the EEA/Eionet system make best use of the indicators in their own work. It is hoped that the guide will promote cooperation on improving indicator methodologies and data quality as part of the wider process to streamline and improve environmental reporting in the European Union and beyond. (au)

  13. Iron Isotope Constraints on Planetesimal Core Formation

    Science.gov (United States)

    Jordan, M.; Young, E. D.

    2016-12-01

    The prevalence of iron in both planetary cores and silicate mantles renders the element a valuable tool for understanding core formation. Magmatic iron meteorites exhibit an enrichment in 57Fe/54Fe relative to chondrites and HED meteorites. This is suggestive of heavy Fe partitioning into the cores of differentiated bodies. If iron isotope fractionation accompanies core formation, we can elucidate details about the history of accretion for planetary bodies as well as their compositions and relative core sizes. The equilibrium 57Fe/54Fe between metal and silicate is necessary for understanding observed iron isotope compositions and placing constraints on core formation. We measure this fractionation in two Aubrite meteorites, Norton County and Mount Egerton, which have known temperatures of equilibration and equilibrated silicon isotopes. Iron was purified using ion-exchange chromatography. Data were collected on a ThermoFinnigan NeptuneTM multiple-collector inductively coupled plasma-source mass spectrometer (MC-ICP-MS) run in wet plasma mode. The measured fractionation Δ57Femetal-silicate is 0.08‰ ± 0.039 (2 SE) for Norton County and 0.09‰ ± 0.019 (2 SE) for Mount Egerton, indicating that the heavy isotopes of Fe partition into the metallic phase. These rocks are in isotopic equilibrium at a temperature of 1130 K and 1200 K ± 80 K, respectively. The concentration of the heavy isotopes of iron in the metallic phase is consistent with recent experimental studies. Using our measured metal-silicate Fe isotope fractionation and the resulting temperature calibration, while taking into account impurities in the metallic phase and temperatures of equilibration, determine that core formation could explain the observed difference between magmatic iron meteorites and chondrites if parent bodies have small cores. In order to verify that Rayleigh distillation during fractional crystallization was not a cause of iron isotope fractionation in iron meteorites, we measured

  14. [Post and core for endodontically treated teeth].

    Science.gov (United States)

    Labropoulou-Tzortzopoulou, E

    1990-01-01

    The literature is replete with the various techniques used in the restoration of pulpless teeth. Controversies surround the most clinically successful procedures and general dentist is confronted daily with the dilemma of choosing the best treatment modality. Endodontically treated posterior teeth present restorative problems. The remaining tooth tissue requires special treatment to prevent further destruction. This report presents an effective method for succeeding extension and protection for endodontically treated teeth. The advantages of the post-core system against other types of restoration, as well the indications are reviewed. In this paper the preparation of the tooth and the construction of a post-core by the direct and indirect method are described.

  15. Full MOX core design for KNGR

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Y. S.; Kim, Y. H.; Lee, K. H. [KEPRI, Taejon (Korea, Republic of)

    1999-10-01

    Nuclear design of KNGR(Korean Next Generation Reactor) is performed to evaluate the feasibility of full MOX(Mixed Oxide, PuO{sub 2}-UO{sub 2}) fuel loading in KNGR core. The reactor core is designed to produce 3983 MWth fission power, 3-batch, 18-month cycle length and Low Leakage Loading Pattern scheme with minimal change in NSSS designs optimized for UO{sub 2} fuel. A hybrid CEA configuration, 50% enriched boron in chemical shim, 5% enriched UO{sub 2} fuel in burnable poison rod have been adopted to guarantee the required shutdown margin and satisfy MSLB accident requirement.

  16. Relation of Core Dominance Parameter and Extended Spectral ...

    Indian Academy of Sciences (India)

    Abstract. The correlations between differences of two core domi- nance parameters and core/extended spectral index are investigated. The extended spectral index is associated with the differences very well, while there is a weak relationship between core spectral index and the differences. The average core spectral index ...

  17. Carbon as the dominant light element in the lunar core

    NARCIS (Netherlands)

    Steenstra, E.S.; Lin, Y.; Rai, N.; Jansen, M.; van Westrenen, W.

    2016-01-01

    Geophysical and geochemical observations point to the presence of a light element in the lunar core, but the exact abundance and type of light element are poorly constrained. Accurate constraints on lunar core composition are vital for models of lunar core dynamo onset and demise, core formation

  18. Relation of Core Dominance Parameter and Extended Spectral ...

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... The correlations between differences of two core dominance parameters and core/extended spectral index are investigated. The extended spectral index is associated with the differences very well, while there is a weak relationship between core spectral index and the differences. The average core ...

  19. Core-shell microparticles for protein sequestration and controlled release of a protein-laden core.

    Science.gov (United States)

    Rinker, Torri E; Philbrick, Brandon D; Temenoff, Johnna S

    2017-07-01

    Development of multifunctional biomaterials that sequester, isolate, and redeliver cell-secreted proteins at a specific timepoint may be required to achieve the level of temporal control needed to more fully regulate tissue regeneration and repair. In response, we fabricated core-shell heparin-poly(ethylene-glycol) (PEG) microparticles (MPs) with a degradable PEG-based shell that can temporally control delivery of protein-laden heparin MPs. Core-shell MPs were fabricated via a re-emulsification technique and the number of heparin MPs per PEG-based shell could be tuned by varying the mass of heparin MPs in the precursor PEG phase. When heparin MPs were loaded with bone morphogenetic protein-2 (BMP-2) and then encapsulated into core-shell MPs, degradable core-shell MPs initiated similar C2C12 cell alkaline phosphatase (ALP) activity as the soluble control, while non-degradable core-shell MPs initiated a significantly lower response (85+19% vs. 9.0+4.8% of the soluble control, respectively). Similarly, when degradable core-shell MPs were formed and then loaded with BMP-2, they induced a ∼7-fold higher C2C12 ALP activity than the soluble control. As C2C12 ALP activity was enhanced by BMP-2, these studies indicated that degradable core-shell MPs were able to deliver a bioactive, BMP-2-laden heparin MP core. Overall, these dynamic core-shell MPs have the potential to sequester, isolate, and then redeliver proteins attached to a heparin core to initiate a cell response, which could be of great benefit to tissue regeneration applications requiring tight temporal control over protein presentation. Tissue repair requires temporally controlled presentation of potent proteins. Recently, biomaterial-mediated binding (sequestration) of cell-secreted proteins has emerged as a strategy to harness the regenerative potential of naturally produced proteins, but this strategy currently only allows immediate amplification and re-delivery of these signals. The multifunctional, dynamic

  20. Coring Methane Hydrate by using Hybrid Pressure Coring System of D/V Chikyu

    Science.gov (United States)

    Kubo, Y.; Mizuguchi, Y.; Inagaki, F.; Eguchi, N.; Yamamoto, K.

    2013-12-01

    Pressure coring is a technique to keep in-situ conditions in recovering sub-seafloor sediment samples, which are potentially rich in soluble or hydrated gas. In regular core sampling, gas fractions are easily lost through the changes in the pressure and temperature during core recovery, and it has significant impact on the chemical components of the sample. Rapid degassing may also cause critical damages of original structures. To study original characteristics of gaseous sub-seafloor sediment, a new Hybrid Pressure Coring System (Hybrid PCS) was developed for the D/V Chikyu operation by adapting some of the existing pressure sampling technologies. Hybrid PCS is composed of three main parts: top section for the wireline operation, middle section for the accumulator and pressure controlling system, and the bottom section for the autoclave chamber. The design concept is based on that of Pressure Core Sampler used in Ocean Drilling Program, and of Pressure Temperature Core Sampler (PTCS) and Non-cooled PTCS of Japan Oil, Gas and Metals National Corporation (JOGMEC). Several modifications were made including that on the ball valve, which operates to close the autoclave after coring. The core samples are 51 mm in diameter and up to 3.5 m in length. The system is combined with the Extented Shoe Coring System on the Chikyu and best suited for coring of semi-consolidated formation up to about 3400 m from the sea level. Sample autoclave is compatible with Pressure Core Analysis and Transfer System (PCATS) of Geotek Ltd for sub-sampling and analysis under in-situ pressure. The analysis in PCATS includes X-ray CT scan and core logging with P-wave velocity and gamma density. Depressurization provides accurate volume of gas and its sub-sampling. Hybrid PCS was first tested during the Chikyu Exp. 906 at a submarine mud-volcano in the Nankai Trough. A 0.9 m of hydrate rich material was recovered from the summit (water depth: 2000 m) and the intact hydrate structure was observed

  1. Study on coherent coupling of multi-core PCFs

    Directory of Open Access Journals (Sweden)

    Yue-E. Chen

    2017-04-01

    Full Text Available In this work, we used R-Soft software to simulate the coupling between multi-core photonic crystal fibers (PCFs with different core diameters and distances. The simulation results show that the core distance within two wavelengths, different core diameters between the mode fields can be effectively coupled. The results are consistent with the evanescent wave propagation length of calculation. According to the designed structure based on the high temperature melting method, the multi-core PCF can be obtained by using two times technique of the optical fiber drawing tower. The core production of (2-, 7-, 19-core PCF of coherent synthesis experiment, observed apparent interference fringes in the experiment, which shows that the mode fields of the multiple cores meet the coherent conditions. This article provides a theoretical basis and guidance to effectively achieve a coherent coupling for the further design and preparation of multi-core fibers (more than 19 cores.

  2. Mode instability in a Yb-doped stretched core fiber

    Science.gov (United States)

    Xia, N.; Yoo, S.

    2017-02-01

    In this work we present the theoretical study of transverse mode instability (TMI) in ytterbium (Yb)-doped rectangular core fibers with different core aspect ratios using the fast Fourier transform (FFT) beam propagation method (BPM). As expected, the rectangular core fiber with larger aspect ratio (AR.) offers more efficient heat dissipation than a circular core fiber. However, it is found that the rectangular core fiber does not benefit from the better heat dissipation to suppress the TMI when compared to the circular core counterpart. The temperature building in the rectangular core fiber decreases by up to 24.6% with a 10:1 aspect ratio core, while threshold pump power drops by up to 38.3% when compared with a circular core fiber with the same core area. Our study reveals that a smaller effective refractive index difference between modes and a weaker gain saturation effect compensate the thermal advantage from more efficient heat dissipation.

  3. Heterogeneous nuclear ribonucleoprotein D/AUF1 interacts with ...

    Indian Academy of Sciences (India)

    In an attempt to characterize the interaction occurring between cellular proteins and hnRNP L, yeast two-hybrid screening was conducted using a HeLa cDNA library. Some of the cDNA clones were found to harbour a partial human hnRNP D/AUF1 cDNA (GeneBank accession number NM_031369). In this study, we ...

  4. Heterogeneous nuclear ribonucleoprotein D/AUF1 interacts with ...

    Indian Academy of Sciences (India)

    SEARCHU

    operated in accordance with the manufacturer's protocols. Saccharomyces cerevisiae strain HF7c (MATa, ura3-52, his3-200, lys2-801, ade2-101, trpl-901, leu2-3, ... Alternatively, the viability of the transformed yeast cells on plates of synthetic medium lacking leucine, tryptophan and histidine was monitored to verify protein–.

  5. Novel monoclonal autoantibody specificity associated with ribonucleoprotein complexes

    Energy Technology Data Exchange (ETDEWEB)

    Winkler, A.; Watson-McKown, R.; Wise, K.

    1986-03-01

    The authors describe an IgG/sub 2a/, kappa monoclonal autoantibody (mAb) F78 derived from a 6-month old MRL-Mp lpr/lpr mouse that recognizes a novel epitope associated with small nuclear ribonuclear protein complexes (snRNP). Indirect immunofluorescent staining of HEp-2 cells with F78 showed a nonnucleolar speckled nuclear pattern characteristic of anti-RNP and anti-Sm mAbs which could be abrogated by pretreating fixed cells with 0.1M HCl prior to staining. Immunoblots of whole cell extracts (dissociated in SDS, urea and mercaptan at 4/sup 0/C then subjected to SDS-PAGE) showed that F78 selectively bound to a component of M/sub r/ = 100,000 clearly distinct from components recognized by two mAbs described by Billings et al that detected, respectively, proteins of M/sub r/ = 70,000 associated with RNP and M/sub r/ = 13,000 associated with Sm. Incubation of extracts at 100/sup 0/C prior to SDS-PAGE eliminated subsequent binding of F78 but not of the other nAbs. F78 as well as the other mAbs selectively immunoprecipitated characteristic patterns of small nuclear RNAs (U/sub 1/, U/sub 2/, U/sub 4/, U/sub 5/, U/sub 6/) from extracts of /sup 32/P-phosphate labeled HeLa cells. These results suggest a new specificity associated with snRNP that is recognized in the MRL autoimmune response.

  6. Nuclear core activity reconstruction using heterogeneous instruments with data assimilation

    OpenAIRE

    Bouriquet Bertrand; Argaud Jean-Philippe; Erhard Patrick; Ponçot Angélique

    2015-01-01

    Evaluating the neutronic state (neutron flux, power…) of the whole nuclear core is a very important topic that has strong implication for nuclear core management and for security monitoring. The core state is evaluated using measurements and calculations. Usually, parts of the measurements are used, and only one kind of instrument is taken into account. However, the core state evaluation should be more accurate when more measurements are collected in the core. But using information from heter...

  7. Rigid polyurethane and kenaf core composite foams

    Science.gov (United States)

    Rigid polyurethane foams are valuable in many construction applications. Kenaf is a bast fiber plant where the surface stem skin provides bast fibers whose strength-to-weight ratio competes with glass fiber. The higher volume product of the kenaf core is an under-investigated area in composite appli...

  8. Explicit Instruction Elements in Core Reading Programs

    Science.gov (United States)

    Child, Angela R.

    2012-01-01

    Classroom teachers are provided instructional recommendations for teaching reading from their adopted core reading programs (CRPs). Explicit instruction elements or what is also called instructional moves, including direct explanation, modeling, guided practice, independent practice, discussion, feedback, and monitoring, were examined within CRP…

  9. Vegetables and other core food groups

    NARCIS (Netherlands)

    Poelman, Astrid A.M.; Delahunty, Conor M.; Graaf, de Kees

    2017-01-01

    Vegetables are the food category least liked by children. This research investigated the sensory properties of vegetables vis-a-vis other core foods that comprise children's diets, to determine to what degree low acceptance of vegetables can be attributed to sensory properties. Vegetables (n =

  10. Lesson Planning with the Common Core

    Science.gov (United States)

    Estes, Linda A.; McDuffie, Amy Roth; Tate, Cathie

    2014-01-01

    Planning a lesson can be similar to planning a road trip--a metaphor the authors use to describe how they applied research and theory to their lesson planning process. A map and mode of transportation, the Common Core State Standards for Mathematics (CCSSM) and textbooks as resources, can lead to desired destinations, such as students engaging in…

  11. Single-Crystal Germanium Core Optoelectronic Fibers

    Energy Technology Data Exchange (ETDEWEB)

    Ji, Xiaoyu [Department of Materials Science and Engineering, Materials Research Institute, Pennsylvania State University, University Park PA 16802 USA; Page, Ryan L. [Department of Materials Science and Engineering, Materials Research Institute, Pennsylvania State University, University Park PA 16802 USA; Chaudhuri, Subhasis [Department of Chemistry, Pennsylvania State University, University Park PA 16802 USA; Liu, Wenjun [Advanced Photon Source, Argonne National Laboratory, Argonne IL 60439 USA; Yu, Shih-Ying [Department of Materials Science and Engineering, Materials Research Institute, Pennsylvania State University, University Park PA 16802 USA; Mohney, Suzanne E. [Department of Materials Science and Engineering, Materials Research Institute, Pennsylvania State University, University Park PA 16802 USA; Badding, John V. [Department of Materials Science and Engineering, Materials Research Institute, Pennsylvania State University, University Park PA 16802 USA; Department of Chemistry, Pennsylvania State University, University Park PA 16802 USA; Department of Physics, Pennsylvania State University, University Park PA 16802 USA; Gopalan, Venkatraman [Department of Materials Science and Engineering, Materials Research Institute, Pennsylvania State University, University Park PA 16802 USA

    2016-09-19

    Synthesis and fabrication of high-quality, small-core single-crystal germanium fibers that are photosensitive at the near-infrared and have low optical losses ≈1 dB cm-1 at 2 μm are reported. These fibers have potential applications in fiber-based spectroscopic imaging, nonlinear optical devices, and photodetection at the telecommunication wavelengths.

  12. Dynamics of dissipative multifluid neutron star cores

    NARCIS (Netherlands)

    Haskell, B.; Andersson, N.; Comer, G.L.

    2012-01-01

    We present a Newtonian multifluid formalism for superfluid neutron star cores, focusing on the additional dissipative terms which arise when one takes into account the individual dynamical degrees of freedom associated with the coupled "fluids." The problem is of direct astrophysical interest as the

  13. Measuring IT core capabilities for electronic commerce

    NARCIS (Netherlands)

    van der Heijden, J.G.M.

    2001-01-01

    This paper reports on the theoretical development and empirical validation of a measurement instrument for three information technology (IT) core capabilities in an electronic commerce context. The instrument is based on the work of Feeny and Willcocks (1998) and includes the capabilities

  14. Complex coacervate core micelles as diffusional nanoprobes

    NARCIS (Netherlands)

    Bourouina, N.; Cohen Stuart, M.A.; Kleijn, J.M.

    2014-01-01

    Because of their ease of preparation and versatile modification opportunities, complex coacervate core micelles (C3Ms) may be a good alternative for expensive diffusional probes, such as dendrimers. However, C3Ms are unstable at high salt concentrations and may fall apart in contact with other

  15. Core-mantle differentiation in Mars

    NARCIS (Netherlands)

    Rai, N.; van Westrenen, W.

    2013-01-01

    The physical and chemical conditions under which Martian core formation took place are not well constrained. We modeled the pressure, temperature, and oxygen fugacity conditions under which it would be possible to match the inferred depletions of moderately siderophile elements Ni, Co, W, Mo, Ga, P,

  16. Core biopsies of the breast: Diagnostic pitfalls

    Directory of Open Access Journals (Sweden)

    Megha Joshi

    2011-01-01

    Full Text Available The incidence of breast cancer is increasing worldwide. In this review article, the authors compare and contrast the incidence of breast cancer, and the inherent differences in the United States (US and India in screening techniques used for diagnosing breast cancer. In spite of these differences, core biopsies of the breast are common for diagnosis of breast cancer in both countries. The authors describe "Best Practices" in the reporting and processing of core biopsies and in the analysis of estrogen receptor (ER, progesterone receptor (PR, and human epidermal growth factor Receptor 2 (Her2/neu. The pitfalls in the diagnosis of fibroepithelial lesions of the breast on core biopsy are discussed, as also the significance of pseudoangiomatous stromal hyperplasia of the breast (PASH is discussed in core biopsy. In this review, the management and diagnosis of flat epithelial atypia and radiation atypia are elaborated and the use of immunohistochemistry (IHC in papillary lesions, phyllodes tumor, and complex sclerosing lesions (radial scars is illustrated. Rarer lesions such as mucinous and histiocytoid carcinoma are also discussed.

  17. Student Voice and the Common Core

    Science.gov (United States)

    Yonezawa, Susan

    2015-01-01

    Common Core proponents and detractors debate its merits, but students have voiced their opinion for years. Using a decade's worth of data gathered through design-research on youth voice, this article discusses what high school students have long described as more ideal learning environments for themselves--and how remarkably similar the Common…

  18. Recovering core identity, hermeneutical and contextual preaching

    African Journals Online (AJOL)

    2016-07-08

    Jul 8, 2016 ... identity – certainly when it answers the questions 'who are we?' and 'what are we called to be and/or do' – it lacks significantly in its missional identity. Contributing factors are mentioned and remedial action is proposed. Recovering core identity, hermeneutical and contextual preaching. Read online:.

  19. How Cultural Knowledge Shapes Core Design Thinking

    DEFF Research Database (Denmark)

    Clemmensen, Torkil; Ranjan, Apara; Bødker, Mads

    2017-01-01

    The growing trend of co-creation and co-design in cross-cultural design teams presents challenges for the design thinking process. We integrate two frameworks, one on reasoning patterns in design thinking, the other on the dynamic constructivist theory of culture, to propose a situation specific ...... core design thinking in specific situations....

  20. Core Dominance Parameter for -Ray Loud Blazars

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... In this paper, we compiled 572 blazars that have known core dominance parameter (log ), out of which 121 blazars are -ray loud blazars. We compared log between 121 blazars and the rest with non -ray detections, and found that -ray loud blazars showed a different distribution, and their average ...

  1. The Lisbon Strategy's Empowerment of Core Executives

    DEFF Research Database (Denmark)

    Borrás, Susana; Peters, B. Guy

    2011-01-01

    advancing (further) centralization and politicization in national patterns of EU policy co-ordination, empowering core executives. The Lisbon Strategy's ideational elements (‘grand’ goals and politically visible targets) as well as organizational requirements (Spring Council, national programming and annual...

  2. Central Core Disease Associated with Elevated Creatine ...

    African Journals Online (AJOL)

    A further example of central core disease is described in a patient with various musculoskeletal abnormalities, who survived two episodes of malignant hyperpyrexia. Similar pathology, though less severe, was found in his asymptomatic mother. S. Afr. Med. J., 48, 640 (1974) ...

  3. Community core evolution in mobile social networks.

    Science.gov (United States)

    Xu, Hao; Xiao, Weidong; Tang, Daquan; Tang, Jiuyang; Wang, Zhenwen

    2013-01-01

    Community detection in social networks attracts a lot of attention in the recent years. Existing methods always depict the relationship of two nodes using the temporary connection. However, these temporary connections cannot be fully recognized as the real relationships when the history connections among nodes are considered. For example, a casual visit in Facebook cannot be seen as an establishment of friendship. Hence, our question is the following: how to cluster the real friends in mobile social networks? In this paper, we study the problem of detecting the stable community core in mobile social networks. The cumulative stable contact is proposed to depict the relationship among nodes. The whole process is divided into timestamps. Nodes and their connections can be added or removed at each timestamp, and historical contacts are considered when detecting the community core. Also, community cores can be tracked through the incremental computing, which can help to recognize the evolving of community structure. Empirical studies on real-world social networks demonstrate that our proposed method can effectively detect stable community cores in mobile social networks.

  4. Central Core Disease Associated with Elevated Creatine ...

    African Journals Online (AJOL)

    A further example of central core disease is described in a patient with various ... The abnormality was also present in the muscle of his mother, although few fibres were involved in her case. The details of this family have been described previously.'" CASE REPORT .... and the case of congenital myopathy associated with ...

  5. Positron annihilation with core and valence electrons

    CERN Document Server

    Green, D G

    2015-01-01

    $\\gamma$-ray spectra for positron annihilation with the core and valence electrons of the noble gas atoms Ar, Kr and Xe is calculated within the framework of diagrammatic many-body theory. The effect of positron-atom and short-range positron-electron correlations on the annihilation process is examined in detail. Short-range correlations, which are described through non-local corrections to the vertex of the annihilation amplitude, are found to significantly enhance the spectra for annihilation on the core orbitals. For Ar, Kr and Xe, the core contributions to the annihilation rate are found to be 0.55\\%, 1.5\\% and 2.2\\% respectively, their small values reflecting the difficulty for the positron to probe distances close to the nucleus. Importantly however, the core subshells have a broad momentum distribution and markedly contribute to the annihilation spectra at Doppler energy shifts $\\gtrsim3$\\,keV, and even dominate the spectra of Kr and Xe at shifts $\\gtrsim5$\\,keV. Their inclusion brings the theoretical ...

  6. CopperCore 3.2

    NARCIS (Netherlands)

    Martens, Harrie; Vogten, Hubert

    2008-01-01

    Available under the GNU GPL license. CopperCore version 3.2 release notes (2008-11-14) ================================================= 2008-05-09 FIXED: changed all references to PropertyLookUp to PropertyLookup in the SQL statements. Caused problems with MySQL in Linux 2008-03-19 CHNGD: added the

  7. Common Core State Standards and Adaptive Teaching

    Science.gov (United States)

    Kamil, Michael L.

    2016-01-01

    This article examines the issues of how Common Core State Standards (CCSS) will impact adaptive teaching. It focuses on 2 of the major differences between conventional standards and CCSS: the increased complexity of text and the addition of disciplinary literacy standards to reading instruction. The article argues that adaptive teaching under CCSS…

  8. Central Core Disease Associated with Elevated Creatine ...

    African Journals Online (AJOL)

    arched palate, ptosis and lumbodorsal scoliosis. The latter abnormality may well have been secondary to the abnor- mality in the right lower extremity. The patient has a brother who has a mild degree of ptosis, high-arched palate, genu valgum and pes cavus. ... areas adjacent to the core region the myofibrils were closely.

  9. Rapidly changing flows in the Earth's core

    DEFF Research Database (Denmark)

    Olsen, Nils; Mandea, M.

    2008-01-01

    recently been used to investigate small-scale core flow(3,4), but no advantage has yet been taken of the improved temporal resolution, partly because the filtering effect of the electrically conducting mantle was assumed to mask short-period magnetic variations(5). Here we show that changes in the magnetic...

  10. Adding calcium improves lithium ferrite core

    Science.gov (United States)

    Lessoff, H.

    1969-01-01

    Adding calcium increases uniformity of grain growth over a wide range of sintering temperatures and reduces porosity within the grain. Ferrite cores containing calcium have square hysteresis loops and high curie temperatures, making them useful in coincident current memories of digital electronic computers.

  11. Modeling in the Common Core State Standards

    Science.gov (United States)

    Tam, Kai Chung

    2011-01-01

    The inclusion of modeling and applications into the mathematics curriculum has proven to be a challenging task over the last fifty years. The Common Core State Standards (CCSS) has made mathematical modeling both one of its Standards for Mathematical Practice and one of its Conceptual Categories. This article discusses the need for mathematical…

  12. Magnetic core-shell silica particles

    NARCIS (Netherlands)

    Claesson, E.M.

    2007-01-01

    This thesis deals with magnetic silica core-shell colloids and related functionalized silica structures. Synthesis routes have been developed and optimized. The physical properties of these colloids have been investigated, such as the magnetic dipole moment, dipolar structure formation and

  13. The Fluxgate Ring-Core Internal Field

    DEFF Research Database (Denmark)

    Primdahl, Fritz; Brauer, Peter; Merayo, José M.G.

    2002-01-01

    . The local demagnetizing factor is used, and the conversion to the average or global factor is derived. Three approximate analytical/numerical calculations of the internal field in the ring-core magnetic material are made. The results are close to the experimental data, supporting the conclusion...

  14. Exploring Function Transformations Using the Common Core

    Science.gov (United States)

    Hall, Becky; Giacin, Rich

    2013-01-01

    When examining transformations of the plane in geometry, teachers typically have students experiment with transformations of polygons. Students are usually quick to notice patterns with ordered pairs. The Common Core State Standard, Geometry, Congruence 2 (G-CO.2), requires students to describe transformations as functions that take points in the…

  15. Development of full MOX core in ABWR

    Energy Technology Data Exchange (ETDEWEB)

    Aoyama, Motoo; Uchikawa, Sadao; Izutsu, Sadayuki; Sasagawa, Masaru; Kaneto, Kunikazu [Hitachi Ltd., Tokyo (Japan)

    1996-10-01

    The feasibility and performance evaluations of the full mixed-oxide (MOX) core in the Advanced BWR (ABWR) were shown as part of the full scale utilization study of MOX fuel. Core design for the ABWR of 3926 MWt with MOX fuel bundles, which have an identical configuration to the STEP II fuel design, was performed from initial to equilibrium cycles. The operating cycle length is 13 months and the discharge exposure for MOX fuel bundles is about 33 GWd/t. In the equilibrium cycle, about one third of the fuel bundles are replaced by reload fresh MOX fuel bundles at the beginning of cycle. The amount of loaded fissile plutonium (Puf) is about 1.4 tons which is equivalent to about 1.1 tons/year. In the initial cycle, the fraction of loaded MOX fuel bundles is about 30%, and the remainder consists of two UO{sub 2} fuel bundle types with different enrichments. In the second and third cycles, about one third of the fuel bundles are replaced by reload fresh MOX fuel bundles at the beginning of each cycle. As a result, the third cycle becomes the full MOX core, and the amount of fissile plutonium loaded for each cycle is about 1.4 - 1.5 tons. Core performance was shown to meet the design criteria. (author)

  16. Expanded Core Curriculum: 12 Years Later

    Science.gov (United States)

    Lohmeier, Keri; Blankenship, Karen; Hatlen, Phil

    2009-01-01

    This study investigated changes in teachers' and parents' understanding and implementation of or philosophy on the implementation of the content areas of the expanded core curriculum for students who are visually impaired. The results demonstrated some changes since the original survey results were reported in 1998 and a discrepancy between the…

  17. Core Competencies for Training Effective School Consultants

    Science.gov (United States)

    Burkhouse, Katie Lynn Sutton

    2012-01-01

    The purpose of this research was to develop and validate a set of core competencies of effective school-based consultants for preservice school psychology consultation training. With recent changes in service delivery models, psychologists are challenged to engage in more indirect, preventative practices (Reschly, 2008). Consultation emerges as…

  18. Doctoral Core Curriculum: A Neglected Challenge?

    Science.gov (United States)

    Pestle, Ruth E.; Wall, Vera J.

    1988-01-01

    This paper reviews the literature on integration of home economics at the graduate level; presents a rationale for a core curriculum; describes objectives and delivery of the curriculum; and proposes research needs to evaluate approaches to training doctoral students in an integrated view of home economics. (JOW)

  19. Reconstitution of fuel assemblies and core components

    Energy Technology Data Exchange (ETDEWEB)

    Langenberge, J.

    2012-07-01

    Due to AREVAS experience and big portfolio of techniques, reconstitution of fuel assemblies and core components at light water reactors is possible within a reasonable time frame and with interesting cost benefit Customer feedback indicates the sustainability of such reconstitutions. As a result, a long-term maintenance of value can be assured and early waste disposal can be avoided.

  20. Marketing Competencies: A Core Course of Study.

    Science.gov (United States)

    Cicchetti, Elric A.

    The document provides a systematic analysis of curriculum in marketing, focusing on the design and evaluation of a vocational course in the distributive education curriculum. The core course, entitled basic marketing, was selected because marketing competencies are essential to every distributive education student. The following areas are…

  1. Noninvasive Measurement of Core Temperature. Phase 1.

    Science.gov (United States)

    Topical Testing proposes the development of a noninvasive device to monitor core temperature by sampling the maximal temperature of the respiratory...air during expiration. Phase I development used a fast rise-time thermocouple to monitor the temperature of the expired air of an anesthetized animal

  2. Comparative Analysis of the 15.5kD Box C/D snoRNP Core Protein in the Primitive Eukaryote Giardia lamblia Reveals Unique Structural and Functional Features

    Energy Technology Data Exchange (ETDEWEB)

    Biswas, Shyamasri; Buhrman, Greg; Gagnon, Keith; Mattos, Carla; Brown, II, Bernard A.; Maxwell, E. Stuart (NCSU); (UTSMC)

    2012-07-11

    Box C/D ribonucleoproteins (RNP) guide the 2'-O-methylation of targeted nucleotides in archaeal and eukaryotic rRNAs. The archaeal L7Ae and eukaryotic 15.5kD box C/D RNP core protein homologues initiate RNP assembly by recognizing kink-turn (K-turn) motifs. The crystal structure of the 15.5kD core protein from the primitive eukaryote Giardia lamblia is described here to a resolution of 1.8 {angstrom}. The Giardia 15.5kD protein exhibits the typical {alpha}-{beta}-{alpha} sandwich fold exhibited by both archaeal L7Ae and eukaryotic 15.5kD proteins. Characteristic of eukaryotic homologues, the Giardia 15.5kD protein binds the K-turn motif but not the variant K-loop motif. The highly conserved residues of loop 9, critical for RNA binding, also exhibit conformations similar to those of the human 15.5kD protein when bound to the K-turn motif. However, comparative sequence analysis indicated a distinct evolutionary position between Archaea and Eukarya. Indeed, assessment of the Giardia 15.5kD protein in denaturing experiments demonstrated an intermediate stability in protein structure when compared with that of the eukaryotic mouse 15.5kD and archaeal Methanocaldococcus jannaschii L7Ae proteins. Most notable was the ability of the Giardia 15.5kD protein to assemble in vitro a catalytically active chimeric box C/D RNP utilizing the archaeal M. jannaschii Nop56/58 and fibrillarin core proteins. In contrast, a catalytically competent chimeric RNP could not be assembled using the mouse 15.5kD protein. Collectively, these analyses suggest that the G. lamblia 15.5kD protein occupies a unique position in the evolution of this box C/D RNP core protein retaining structural and functional features characteristic of both archaeal L7Ae and higher eukaryotic 15.5kD homologues.

  3. Improving the calculated core stability by the core nuclear design optimization

    Energy Technology Data Exchange (ETDEWEB)

    Partanen, P. [Teollisuuden Voima Oy, Olkiluoto (Finland)

    1995-12-31

    Three different equilibrium core loadings for TVO II reactor have been generated in order to improve the core stability properties at uprated power level. The reactor thermal power is assumed to be uprated from 2160 MW{sub th} to 2500 MW{sub th}, which moves the operating point after a rapid pump rundown where the core stability has been calculated from 1340 MW{sub th} and 3200 kg/s to 1675 MW{sub th} and 4000 kg/s. The core has been refuelled with ABB Atom Svea-100 -fuel, which has 3,64% w/o U-235 average enrichment in the highly enriched zone. PHOENIX lattice code has been used to provide the homogenized nuclear constants. POLCA4 static core simulator has been used for core loadings and cycle simulations and RAMONA-3B program for simulating the dynamic response to the disturbance for which the stability behaviour has been evaluated. The core decay ratio has been successfully reduced from 0,83 to 0,55 mainly by reducing the power peaking factors. (orig.) (7 figs., 1 tab.).

  4. THE ENIGMATIC CORE L1451-mm: A FIRST HYDROSTATIC CORE? OR A HIDDEN VeLLO?

    Energy Technology Data Exchange (ETDEWEB)

    Pineda, Jaime E.; Goodman, Alyssa A.; Bourke, Tyler; Foster, Jonathan B.; Robitaille, Thomas; Kauffmann, Jens [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Arce, Hector G.; Tanner, Joel [Department of Astronomy, Yale University, P.O. Box 208101, New Haven, CT 06520-8101 (United States); Schnee, Scott [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Tafalla, Mario [Observatorio Astronomico Nacional (IGN), Alfonso XII 3, E-28014 Madrid (Spain); Caselli, Paola [School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT (United Kingdom); Anglada, Guillem, E-mail: jaime.pineda@manchester.ac.uk [Instituto de Astrofisica de Andalucia, CSIC, Apartado 3004, E-18080 Granada (Spain)

    2011-12-20

    We present the detection of a dust continuum source at 3 mm (CARMA) and 1.3 mm (Submillimeter Array, SMA), and {sup 12}CO (2-1) emission (SMA) toward the L1451-mm dense core. These detections suggest a compact object and an outflow where no point source at mid-infrared wavelengths is detected using Spitzer. An upper limit for the dense core bolometric luminosity of 0.05 L{sub Sun} is obtained. By modeling the broadband spectral energy distribution and the continuum interferometric visibilities simultaneously, we confirm that a central source of heating is needed to explain the observations. This modeling also shows that the data can be well fitted by a dense core with a young stellar object (YSO) and a disk, or by a dense core with a central first hydrostatic core (FHSC). Unfortunately, we are not able to decide between these two models, which produce similar fits. We also detect {sup 12}CO (2-1) emission with redshifted and blueshifted emission suggesting the presence of a slow and poorly collimated outflow, in opposition to what is usually found toward YSOs but in agreement with prediction from simulations of an FHSC. This presents the best candidate, so far, for an FHSC, an object that has been identified in simulations of collapsing dense cores. Whatever the true nature of the central object in L1451-mm, this core presents an excellent laboratory to study the earliest phases of low-mass star formation.

  5. Imaging the Moon's Core with Seismology

    Science.gov (United States)

    Weber, Renee C.; Lin, Pei-Ying Patty; Garnero, Ed J.; Williams, Quetin C.; Lognonne, Philippe

    2011-01-01

    Constraining the structure of the lunar core is necessary to improve our understanding of the present-day thermal structure of the interior and the history of a lunar dynamo, as well as the origin and thermal and compositional evolution of the Moon. We analyze Apollo deep moonquake seismograms using terrestrial array processing methods to search for the presence of reflected and converted energy from the lunar core. Although moonquake fault parameters are not constrained, we first explore a suite of theoretical focal spheres to verify that fault planes exist that can produce favorable core reflection amplitudes relative to direct up-going energy at the Apollo stations. Beginning with stacks of event seismograms from the known distribution of deep moonquake clusters, we apply a polarization filter to account for the effects of seismic scattering that (a) partitions energy away from expected components of ground motion, and (b) obscures all but the main P- and S-wave arrivals. The filtered traces are then shifted to the predicted arrival time of a core phase (e.g. PcP) and stacked to enhance subtle arrivals associated with the Moon s core. This combination of filtering and array processing is well suited for detecting deep lunar seismic reflections, since we do not expect scattered wave energy from near surface (or deeper) structure recorded at varying epicentral distances and stations from varying moonquakes at varying depths to stack coherently. Our results indicate the presence of a solid inner and fluid outer core, overlain by a partial-melt-containing boundary layer (Table 1). These layers are consistently observed among stacks from four classes of reflections: P-to-P, S-to-P, P-to-S, and S-to-S, and are consistent with current indirect geophysical estimates of core and deep mantle properties, including mass, moment of inertia, lunar laser ranging, and electromagnetic induction. Future refinements are expected following the successful launch of the GRAIL lunar

  6. Conceptual study of advanced PWR core design. Development of advanced PWR core neutronics analysis system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chang Hyo; Kim, Seung Cho; Kim, Taek Kyum; Cho, Jin Young; Lee, Hyun Cheol; Lee, Jung Hun; Jung, Gu Young [Seoul National University, Seoul (Korea, Republic of)

    1995-08-01

    The neutronics design system of the advanced PWR consists of (i) hexagonal cell and fuel assembly code for generation of homogenized few-group cross sections and (ii) global core neutronics analysis code for computations of steady-state pin-wise or assembly-wise core power distribution, core reactivity with fuel burnup, control rod worth and reactivity coefficients, transient core power, etc.. The major research target of the first year is to establish the numerical method and solution of multi-group diffusion equations for neutronics code development. Specifically, the following studies are planned; (i) Formulation of various numerical methods such as finite element method(FEM), analytical nodal method(ANM), analytic function expansion nodal(AFEN) method, polynomial expansion nodal(PEN) method that can be applicable for the hexagonal core geometry. (ii) Comparative evaluation of the numerical effectiveness of these methods based on numerical solutions to various hexagonal core neutronics benchmark problems. Results are follows: (i) Formulation of numerical solutions to multi-group diffusion equations based on numerical methods. (ii) Numerical computations by above methods for the hexagonal neutronics benchmark problems such as -VVER-1000 Problem Without Reflector -VVER-440 Problem I With Reflector -Modified IAEA PWR Problem Without Reflector -Modified IAEA PWR Problem With Reflector -ANL Large Heavy Water Reactor Problem -Small HTGR Problem -VVER-440 Problem II With Reactor (iii) Comparative evaluation on the numerical effectiveness of various numerical methods. (iv) Development of HEXFEM code, a multi-dimensional hexagonal core neutronics analysis code based on FEM. In the target year of this research, the spatial neutronics analysis code for hexagonal core geometry(called NEMSNAP-H temporarily) will be completed. Combination of NEMSNAP-H with hexagonal cell and assembly code will then equip us with hexagonal core neutronics design system. (Abstract Truncated)

  7. Palaeointensity, core thermal conductivity and the unknown age of the inner core

    Science.gov (United States)

    Smirnov, Aleksey V.; Tarduno, John A.; Kulakov, Evgeniy V.; McEnroe, Suzanne A.; Bono, Richard K.

    2016-05-01

    Data on the evolution of Earth's magnetic field intensity are important for understanding the geodynamo and planetary evolution. However, the paleomagnetic record in rocks may be adversely affected by many physical processes, which must be taken into account when analysing the palaeointensity database. This is especially important in the light of an ongoing debate regarding core thermal conductivity values, and how these relate to the Precambrian geodynamo. Here, we demonstrate that several data sets in the Precambrian palaeointensity database overestimate the true paleofield strength due to the presence of non-ideal carriers of palaeointensity signals and/or viscous re-magnetizations. When the palaeointensity overestimates are removed, the Precambrian database does not indicate a robust change in geomagnetic field intensity during the Mesoproterozoic. These findings call into question the recent claim that the solid inner core formed in the Mesoproterozoic, hence constraining the thermal conductivity in the core to `moderate' values. Instead, our analyses indicate that the presently available palaeointensity data are insufficient in number and quality to constrain the timing of solid inner core formation, or the outstanding problem of core thermal conductivity. Very young or very old inner core ages (and attendant high or low core thermal conductivity values) are consistent with the presently known history of Earth's field strength. More promising available data sets that reflect long-term core structure are geomagnetic reversal rate and field morphology. The latter suggests changes that may reflect differences in Archean to Proterozoic core stratification, whereas the former suggest an interval of geodynamo hyperactivity at ca. 550 Ma.

  8. Topography of Earth's Inner Core Boundary

    Science.gov (United States)

    Cormier, V. F.; Zheng, Y.; Hernlund, J. W.

    2011-12-01

    Lateral variations in the structure and crystallization of the inner core will likely be associated with lateral variations in the topography of its boundary. Depending on liquid fraction and the ratio of solid over liquid viscosity, the process of compaction of solids and expulsion of fluids at the solidifying boundary can be dynamically unstable, resulting in small-scale corrugations of the boundary of 0.1 to 5 km height with a horizontal scale on the order of 1 to 10 km. Evidence of such ICB topography has been inferred from waveforms of PKiKP doublets (1). An additional observation consistent ICB topography includes the seismic wave diffracted around the top of the inner core (PKP-Cdiff), whose travel time agrees with that predicted by the AK135 Earth model, but whose amplitude decays more rapidly into the inner core shadow than is predicted by AK135 (2). These observations are modeled by synthesizing seismic body waves with a pseudospectral method (3) having a densified grid in the vicinity of a rough ICB. Validation of the forward modeling includes a comparison of results obtained with a boundary element method. Modeled spectra of ICB topography are used to constrain the parameters and processes that produce the topography. These include compaction length (assuming freezing upward from below), the structure of precipitated piles (assuming metallic snow falling from above), the sedimentary processes due to flow in the overlying F-layer of the outer core, and the relaxation of topography from viscous deformation of the inner core. 1. Cao, A., Y. Masson, and B. Romanowicz, PNAS, 104, 31-35, 2007. 2. Zou, Z., K. Koper, and V.F. Cormier, J. Geophys. Res., 113, 2008. doi: 10.1029/2007JB005316. 3. Furumura T., B.L.N. Kennett, and M. Furumura, Geophys. J. Int., 135, 845--860, 1998.

  9. Recurrent Acute Tonsillitis, The 'Core' Issue

    Directory of Open Access Journals (Sweden)

    Saikat Samaddar

    2016-04-01

    Full Text Available Introduction: Today bacteriological and patho-anatomical considerations too are taken into account while treating a case of tonsillitis. Past decade has seen the rise of resistance amongst the common pathogens, as well as rise in the number of unusual offenders. Determination of the true offending organism and prescribing an antibiotic as per the sensitivity pattern is of utmost importance.  Materials and Method: A prospective longitudinal study was conducted in a tertiary care hospital in Kolkata. The study population consisted of patients presenting with recurrent attacks of acute tonsillitis. Determination of throat swab micro flora, ASO titre and core tissue microflora was done and correlated statistically. Result: There was poor correlation between throat swab and core tissue microflora. Positive predictive value of throat swab was 10%. Pseudomonas is the predominant flora harbouring tonsillar core in our study population. Amoxicillin the most commonly prescribed antibiotic stands out to be the most resistant one. No statistical significance could be reached comparing streptococcal tonsillitis with ASO titre. Discussion: The real pathology within the tonsil core is not always reflected in routine throat swab and bacteriology of recurrent tonsillitis may differ in different regions. ASO titre estimation adds up to the economic burden if rheumatic fever is not suspected. Judicious use of antibiotics based on true sensitivity pattern is encouraged. In the era of antibiotics Tonsillectomy still holds an important position in the management of recurrent attacks. Conclusion: Pseudomonas was found to be the most common pathogen in recurrent acute tonsillitis. Core tissue study remains the Gold standard in identifying the pathogenic organism. Oral third generation Cephalosporin was the most efficacious antibiotic for recurrent tonsillitis in our study population.

  10. COOL CORE CLUSTERS FROM COSMOLOGICAL SIMULATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Rasia, E.; Borgani, S.; Murante, G.; Planelles, S.; Biffi, V.; Granato, G. L. [INAF, Osservatorio Astronomico di Trieste, via Tiepolo 11, I-34131, Trieste (Italy); Beck, A. M.; Steinborn, L. K.; Dolag, K. [Universitäts-Sternwarte München, Scheinerstr.1, D-81679 München (Germany); Ragone-Figueroa, C., E-mail: rasia@oats.inaf.it [Instituto de Astronomá Teórica y Experimental (IATE), Consejo Nacional de Investigaciones Cientiíficas y Técnicas de la República Argentina (CONICET), Observatorio Astronómico, Universidad Nacional de Córdoba, Laprida 854, X5000BGR, Córdoba (Argentina)

    2015-11-01

    We present results obtained from a set of cosmological hydrodynamic simulations of galaxy clusters, aimed at comparing predictions with observational data on the diversity between cool-core (CC) and non-cool-core (NCC) clusters. Our simulations include the effects of stellar and active galactic nucleus (AGN) feedback and are based on an improved version of the smoothed particle hydrodynamics code GADGET-3, which ameliorates gas mixing and better captures gas-dynamical instabilities by including a suitable artificial thermal diffusion. In this Letter, we focus our analysis on the entropy profiles, the primary diagnostic we used to classify the degree of cool-coreness of clusters, and the iron profiles. In keeping with observations, our simulated clusters display a variety of behaviors in entropy profiles: they range from steadily decreasing profiles at small radii, characteristic of CC systems, to nearly flat core isentropic profiles, characteristic of NCC systems. Using observational criteria to distinguish between the two classes of objects, we find that they occur in similar proportions in both simulations and observations. Furthermore, we also find that simulated CC clusters have profiles of iron abundance that are steeper than those of NCC clusters, which is also in agreement with observational results. We show that the capability of our simulations to generate a realistic CC structure in the cluster population is due to AGN feedback and artificial thermal diffusion: their combined action allows us to naturally distribute the energy extracted from super-massive black holes and to compensate for the radiative losses of low-entropy gas with short cooling time residing in the cluster core.

  11. Towards gold shells shaped by carbon cores: From a gold cage to a core shell aurocarbon

    Science.gov (United States)

    Naumkin, Fedor Y.

    2008-11-01

    A new aurocarbon species, C 10Au 18, is investigated in terms of its geometry, stability, charge distribution and properties involving changes of the electronic and charge state. The system consists of a carbon-radical core inside a gold shell. The property variations upon adding the carbon molecular 'dopant' to the gold cage cluster of equivalent geometry are analyzed via isolating the effects of the shell shape change and core influence. The charge distribution in the system exhibits interesting, sometimes counterintuitive features. An approximate splitting of the total binding energy into the in-shell and core-shell components is attempted, indicating comparable values for both.

  12. Family and infant characteristics associated with timing of core and non-core food introduction in early childhood.

    Science.gov (United States)

    Schrempft, S; van Jaarsveld, C H M; Fisher, A; Wardle, J

    2013-06-01

    To identify family and infant characteristics associated with timing of introduction of two food types: core foods (nutrient-dense) and non-core foods (nutrient-poor) in a population-based sample of mothers and infants. Participants were 1861 mothers and infants from the Gemini twin birth cohort (one child per family). Family and infant characteristics were assessed when the infants were around 8 months old. Timing of introducing core and non-core foods was assessed at 8 and 15 months. As the distributions of timing were skewed, three similar-sized groups were created for each food type: earlier (core: 1-4 months; non-core: 3-8 months), average (core: 5 months; non-core: 9-10 months) and later introduction (core: 6-12 months; non-core: 11-18 months). Ordinal logistic regression was used to examine predictors of core and non-core food introduction, with bootstrapping to test for differences between the core and non-core models. Younger maternal age, lower education level and higher maternal body mass index were associated with earlier core and non-core food introduction. Not breastfeeding for at least 3 months and higher birth weight were specifically associated with earlier introduction of core foods. Having older children was specifically associated with earlier introduction of non-core foods. There are similarities and differences in the characteristics associated with earlier introduction of core and non-core foods. Successful interventions may require a combination of approaches to target both food types.

  13. High performance carbon nanotube-Si core-shell wires with a rationally structured core for lithium ion battery anodes.

    Science.gov (United States)

    Fan, Yu; Zhang, Qing; Lu, Congxiang; Xiao, Qizhen; Wang, Xinghui; Tay, Beng Kang

    2013-02-21

    Core-shell Si nanowires are very promising anode materials. Here, we synthesize vertically aligned carbon nanotubes (CNTs) with relatively large diameters and large inter-wire spacing as core wires and demonstrate a CNT-Si core-shell wire composite as a lithium ion battery (LIB) anode. Owing to the rationally engineered core structure, the composite shows good capacity retention and rate performance. The excellent performance is superior to most core-shell nanowires previously reported.

  14. The thermal evolution of Mercury's Fe-Si core

    Science.gov (United States)

    Knibbe, Jurriën Sebastiaan; van Westrenen, Wim

    2018-01-01

    We have studied the thermal and magnetic field evolution of planet Mercury with a core of Fe-Si alloy to assess whether an Fe-Si core matches its present-day partially molten state, Mercury's magnetic field strength, and the observed ancient crustal magnetization. The main advantages of an Fe-Si core, opposed to a previously assumed Fe-S core, are that a Si-bearing core is consistent with the highly reduced nature of Mercury and that no compositional convection is generated upon core solidification, in agreement with magnetic field indications of a stable layer at the top of Mercury's core. This study also present the first implementation of a conductive temperature profile in the core where heat fluxes are sub-adiabatic in a global thermal evolution model. We show that heat migrates from the deep core to the outer part of the core as soon as heat fluxes at the outer core become sub-adiabatic. As a result, the deep core cools throughout Mercury's evolution independent of the temperature evolution at the core-mantle boundary, causing an early start of inner core solidification and magnetic field generation. The conductive layer at the outer core suppresses the rate of core growth after temperature differences between the deep and shallow core are relaxed, such that a magnetic field can be generated until the present. Also, the outer core and mantle operate at higher temperatures than previously thought, which prolongs mantle melting and mantle convection. The results indicate that S is not a necessary ingredient of Mercury's core, bringing bulk compositional models of Mercury more in line with reduced meteorite analogues.

  15. Crystal structure of a core spliceosomal protein interface

    Science.gov (United States)

    Schellenberg, Matthew J.; Edwards, Ross A.; Ritchie, Dustin B.; Kent, Oliver A.; Golas, Monika M.; Stark, Holger; Lührmann, Reinhard; Glover, J. N. Mark; MacMillan, Andrew M.

    2006-01-01

    The precise excision of introns from precursor mRNAs (pre-mRNAs) in eukaryotes is accomplished by the spliceosome, a complex assembly containing five small nuclear ribonucleoprotein (snRNP) particles. Human p14, a component of the spliceosomal U2 and U11/U12 snRNPs, has been shown to associate directly with the pre-mRNA branch adenosine early in spliceosome assembly and within the fully assembled spliceosome. Here we report the 2.5-Å crystal structure of a complex containing p14 and a peptide derived from the p14-associated U2 snRNP component SF3b155. p14 contains an RNA recognition motif (RRM), the surface of which is largely occluded by a C-terminal α-helix and a portion of the SF3b155 peptide. An analysis of RNA·protein crosslinking to wild-type and mutant p14 shows that the branch adenosine directly interacts with a conserved aromatic within a pocket on the surface of the complex. This result, combined with a comparison of the structure with known RRMs and pseudoRRMs as well as model-building by using the electron cryomicroscopy structure of a spliceosomal U11/U12 di-snRNP, suggests that p14·SF3b155 presents a noncanonical surface for RNA recognition at the heart of the mammalian spliceosome. PMID:16432215

  16. DNA compaction by poly (amido amine) dendrimers of ammonia cored and ethylene diamine cored

    Science.gov (United States)

    Qamhieh, K.; Al-Shawwa, J.

    2017-06-01

    The complexes build-up of DNA and soft particles poly amidoamine (PAMAM) dendrimers of ammonia cored of generations (G1-G6) and ethylenediamine cored of generations (G1-G10) have been studied, using a new theoretical model developed by Qamhieh and coworkers. The model describes the interaction between linear polyelectrolyte (LPE) chain and ion-penetrable spheres. Many factors affecting LPE/dendrimer complex have been investigated such as dendrimer generation, the Bjerrum length, salt concentration, and rigidity of the LPE chain represented by the persistence length. It is found that the wrapping chain length around dendrimer increases by increasing dendrimer`s generation, Bjerrum length, and salt concentration, while decreases by increasing the persistence length of the LPE chain. Also we can conclude that the wrapping length of LPE chain around ethylenediamine cored dendrimers is larger than its length around ammonia cored dendrimers.

  17. Bayesian Inversion of Earth's Core and Inner Core Resonances From Superconducting Gravimeter and VLBI Nutation Data

    Science.gov (United States)

    Rosat, S.; Lambert, S. B.; Gattano, C.; Calvo, M.

    2016-12-01

    Under the tidal forcing of the Moon, Sun and other planets, the Earth's figure axis undergoes periodic oscillations in space, called nutations. Due to the same forcing, the Earth is deformed and the surface gravity field is disturbed. Space nutations are regularly observed by the international network of very large band interferometric antenna (VLBI) and time variations of the Earth's surface gravity are continuously recorded by an international network of Superconducting Gravimeters (SGs). Because of the presence of an elliptical liquid core inside the Earth, an additional periodic oscillation exists: the Free Core Nutation (FCN), with a quasi-diurnal period in Earth-fixed reference frame and a retrograde motion of about 430 days in a space-fixed reference frame. Besides, the presence of a slightly tilted and oblate solid inner core in the fluid outer core gives rise to the Free Inner Core Nutation (FICN). In a terrestrial reference frame, the FICN has a nearly diurnal prograde motion. The Earth's response to the tidal forcing leads to a resonance effect when the forcing frequency is close to the eigenfrequency of a normal mode. The resonance perturbs amplitudes and phases of the tidal waves observed by gravimetry and of the nutations observed by VLBI. In turn, the precise determination of the tidal and nutation amplitudes allows one to determine the frequencies associated with the resonances, and, thereby, some geophysical parameters entering the expressions of the resonant frequencies: dynamical ellipticities and densities of the inner core and outer core, deformabilities of the core boundaries under fluid pressure, constants characterizing the visco-magnetic coupling at the core boundaries, viscosity of the inner core, friction at inner core boundary and topographic torques at the interfaces. We use the Metropolis-Hastings algorithm with a Markov Chain Monte-Carlo (MCMC) method to perform the Bayesian inversion of the resonance parameters from SG gravity and

  18. Feasibility Study of Core Design with a Monte Carlo Code for APR1400 Initial core

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jinsun; Chang, Do Ik; Seong, Kibong [KEPCO NF, Daejeon (Korea, Republic of)

    2014-10-15

    The Monte Carlo calculation becomes more popular and useful nowadays due to the rapid progress in computing power and parallel calculation techniques. There have been many attempts to analyze a commercial core by Monte Carlo transport code using the enhanced computer capability, recently. In this paper, Monte Carlo calculation of APR1400 initial core has been performed and the results are compared with the calculation results of conventional deterministic code to find out the feasibility of core design using Monte Carlo code. SERPENT, a 3D continuous-energy Monte Carlo reactor physics burnup calculation code is used for this purpose and the KARMA-ASTRA code system, which is used for a deterministic code of comparison. The preliminary investigation for the feasibility of commercial core design with Monte Carlo code was performed in this study. Simplified core geometry modeling was performed for the reactor core surroundings and reactor coolant model is based on two region model. The reactivity difference at HZP ARO condition between Monte Carlo code and the deterministic code is consistent with each other and the reactivity difference during the depletion could be reduced by adopting the realistic moderator temperature. The reactivity difference calculated at HFP, BOC, ARO equilibrium condition was 180 ±9 pcm, with axial moderator temperature of a deterministic code. The computing time will be a significant burden at this time for the application of Monte Carlo code to the commercial core design even with the application of parallel computing because numerous core simulations are required for actual loading pattern search. One of the remedy will be a combination of Monte Carlo code and the deterministic code to generate the physics data. The comparison of physics parameters with sophisticated moderator temperature modeling and depletion will be performed for a further study.

  19. Study on core physics characteristics of high burn-up full MOX PWR core. 2

    Energy Technology Data Exchange (ETDEWEB)

    Kugo, Teruhiko; Okubo, Tsutomu; Shimada, Syoichiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1999-09-01

    As one of options for future light water reactors, we have been studying a new concept of a high burn-up full MOX PWR core with a discharge burn-up of 100 GWd/t and a 3-year operation cycle being based on the existing light water reactor technology. We have already confirmed the feasibility of the core, in which a moderator to fuel volume ratio(Vm/Vf) is increased to 2.6 with the same fuel pin diameter of 9.5 mm as in the current PWR but with the enlarged fuel pin pitch of 13.8 mm. In this report, to improve the neutronics and thermal hydraulic performance of the high burn-up core, we subsequently propose a 600 MWe core ensuring discharge burn-up of 100 GWd/t by increasing Vm/Vf to 3.0 with the same fuel pin pitch of 12.6 mm as in the current PWR and the smaller fuel rod diameter of 8.3 mm instead of 9.5 mm. We have investigated its core characteristics in neutronics and confirmed its feasibility. The core neutronics performance is compared between Vm/Vf = 2.6 and 3.0. From the comparison, it is found that the proposed core with Vm/Vf 3.0 has more promising characteristics than with Vm/Vf = 2.6 such as saving of a fissile plutonium content of 0.3wt%, improvement in a departure from nucleate boiling ratio (DNBR) and so on, except for a shortened cycle length by 9%. In addition, we have investigated a low-leakage refueling scheme for both types of high burn-up cores. Without modification to fuel material such as addition of burnable poison and/or transuranium isotopes, it can not be expected to improve the burn-up efficiency by the low-leakage refueling scheme. (author)

  20. Core Handling and Real-Time Non-Destructive Characterization at the Kochi Core Center: An Example of Core Analysis from the Chelungpu Fault

    Directory of Open Access Journals (Sweden)

    W. Lin

    2007-11-01

    Full Text Available As an example of core analysis carried out inactive fault drilling programs, we report the procedures of core handling on the drilling site and non-destructive characterization in the laboratory. This analysis was employed onthe core samples taken from HoleBof the Taiwan Chelungpu-fault Drilling Project (TCDP, which penetrated through the active fault that slipped during the 1999 Chi-Chi, Taiwan earthquake. We show results of the non-destructive physical property measurements carried out at the Kochi Core Center (KCC, Japan. Distinct anomalies of lower bulk density and higher magnetic susceptibilitywere recognized in all three fault zones encountered in HoleB. To keep the core samples in good condition before they are used for variousanalyses is crucial. In addition, careful planning for core handlingand core analyses is necessary for successfulinvestigations. doi:10.2204/iodp.sd.s01.35.2007

  1. Thermal evolution and core formation of planetesimals

    Science.gov (United States)

    Suwa, Taichi; Nagahara, Hiroko

    2017-04-01

    Planetesimals did not get an adequate thermal energy by accretion to form large scale magma ocean because of smaller radii, masses, gravity and accretion energy, however, there are various evidences for the presence of core in planetesimals: 4-Vesta has a core and non-magmatic iron meteorites were segregated metal in bodies that did not experience silicate melting. It has been pointed out that accretion time of planetesimals controls melting and differentiation, because short lived nuclides are plausible heat source. Other factors such as radiative cooling from the surface and thermal conductivity, would also affect thermal evolution of planetesimals. Furthermore, percolation of Fe-S melt through silicate matrix is controlled by the porosity and grain size of silicates and dihedral angle between the melt and silicates. Therefore, the interior structure of planetesimals should be considered by taking the accretion, growth, and thermal evolution of the interior simultaneously. We make a numerical simulation with a spherical 1D model on the basis of the model by Neuman, which is a non-stationary heat conduction equation. We specifically pay attention to the process at temperatures between eutectic temperature Fe-FeS (1213K) and silicate solidus (1425K) and the surface tension of the melt that governs percolation. The model contains three free parameters, formation time, accretion duration, and final size of the planetesimals. The results show that the interior structure can be divided to four types: Type A is undifferentiated, Type B is differentiated to core and mantle of which core was formed by Fe-S melt percolation, Type C is partially differentiated to FeS core and mantle, where mantle retains residual Fe metal, and Type D is differentiated to core and mantle by metal separation in silicate magma. Type A would correspond to the parent bodies of chondrites, and Type B (and Type C?) core would be the source of non-magmatic iron meteorites. Type D would be parent

  2. A long-lived lunar core dynamo.

    Science.gov (United States)

    Shea, Erin K; Weiss, Benjamin P; Cassata, William S; Shuster, David L; Tikoo, Sonia M; Gattacceca, Jérôme; Grove, Timothy L; Fuller, Michael D

    2012-01-27

    Paleomagnetic measurements indicate that a core dynamo probably existed on the Moon 4.2 billion years ago. However, the subsequent history of the lunar core dynamo is unknown. Here we report paleomagnetic, petrologic, and (40)Ar/(39)Ar thermochronometry measurements on the 3.7-billion-year-old mare basalt sample 10020. This sample contains a high-coercivity magnetization acquired in a stable field of at least ~12 microteslas. These data extend the known lifetime of the lunar dynamo by 500 million years. Such a long-lived lunar dynamo probably required a power source other than thermochemical convection from secular cooling of the lunar interior. The inferred strong intensity of the lunar paleofield presents a challenge to current dynamo theory.

  3. An ancient core dynamo in asteroid Vesta.

    Science.gov (United States)

    Fu, Roger R; Weiss, Benjamin P; Shuster, David L; Gattacceca, Jérôme; Grove, Timothy L; Suavet, Clément; Lima, Eduardo A; Li, Luyao; Kuan, Aaron T

    2012-10-12

    The asteroid Vesta is the smallest known planetary body that has experienced large-scale igneous differentiation. However, it has been previously uncertain whether Vesta and similarly sized planetesimals formed advecting metallic cores and dynamo magnetic fields. Here we show that remanent magnetization in the eucrite meteorite Allan Hills A81001 formed during cooling on Vesta 3.69 billion years ago in a surface magnetic field of at least 2 microteslas. This field most likely originated from crustal remanence produced by an earlier dynamo, suggesting that Vesta formed an advecting liquid metallic core. Furthermore, the inferred present-day crustal fields can account for the lack of solar wind ion-generated space weathering effects on Vesta.

  4. Assessment of CRBR core disruptive accident energetics

    Energy Technology Data Exchange (ETDEWEB)

    Theofanous, T.G.; Bell, C.R.

    1984-03-01

    The results of an independent assessment of core disruptive accident energetics for the Clinch River Breeder Reactor are presented in this document. This assessment was performed for the Nuclear Regulatory Commission under the direction of the CRBR Program Office within the Office of Nuclear Reactor Regulation. It considered in detail the accident behavior for three accident initiators that are representative of three different classes of events; unprotected loss of flow, unprotected reactivity insertion, and protected loss of heat sink. The primary system's energetics accommodation capability was realistically, yet conservatively, determined in terms of core events. This accommodation capability was found to be equivalent to an isentropic work potential for expansion to one atmosphere of 2550 MJ or a ramp rate of about 200 $/s applied to a classical two-phase disassembly.

  5. Differential Stoichiometry among Core Ribosomal Proteins

    Directory of Open Access Journals (Sweden)

    Nikolai Slavov

    2015-11-01

    Full Text Available Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its dysregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs, some experiments suggest a more variable composition. Testing such variability requires direct and precise quantification of RPs. We used mass spectrometry to directly quantify RPs across monosomes and polysomes of mouse embryonic stem cells (ESC and budding yeast. Our data show that the stoichiometry among core RPs in wild-type yeast cells and ESC depends both on the growth conditions and on the number of ribosomes bound per mRNA. Furthermore, we find that the fitness of cells with a deleted RP-gene is inversely proportional to the enrichment of the corresponding RP in polysomes. Together, our findings support the existence of ribosomes with distinct protein composition and physiological function.

  6. Development tendencies of moulding and core sands

    Directory of Open Access Journals (Sweden)

    Stanislaw M. Dobosz1

    2011-11-01

    Full Text Available Further development of the technology for making moulding and core sands will be strictly limited by tough requirements due to protection of the natural environment. These tendencies are becoming more and more tense, so that we will reach a point when even processes, that from technological point of view fulfill high requirements of the foundry industry, must be replaced by more ecologically-friendly solutions. Hence, technologies using synthetic resins as binding materials will be limited. This paper presents some predictable development tendencies of moulding and core sands. The increasing role of inorganic substances will be noticed, including silicate binders with significantly improved properties, such as improved knock-out property or higher reclamation strength. Other interesting solutions might also be moulding sands bonded by geo-polymers and phosphate binders or salts and also binders based on degradable biopolymers. These tendencies and the usefulness of these binders are put forward in this paper.

  7. LWR core meltdown accident sequence phenomenology

    Energy Technology Data Exchange (ETDEWEB)

    Cybulskis, P.; Wooton, R.; Kolb, G.J.

    1982-01-01

    The Reactor Safety Study Methodology Applications Program (RSSMAP) conducted risk analyses of four light water reactors. The plants studied were each designed by a different US reactor vendor and are enclosed within three different containment types. These plants were chosen because they are significantly different from those analyzed in the Reactor Safety Study (RSS). One of the products of the RSSMAP was a characterization of the physical processes associated with a variety of core melt accidents. This paper summarizes the results of the core meltdown analysis and outlines how they can be integrated into the analysis of a similar plant. Risk analyses of plants, which are similar to the four RSSMAP plants, are expected in the future as part of several NRC and industry sponsored programs.

  8. Evaluation of tight-pitch PWR cores

    Energy Technology Data Exchange (ETDEWEB)

    Correa, F.; Driscoll, M.J.; Lanning, D.D.

    1979-08-01

    The impact of tight pinch cores on the consumption of natural uranium ore has been evaluated for two systems of coupled PWR's namely one particular type of thorium system - /sup 235/U/UO/sub 2/ : Pu/ThO/sub 2/ : /sup 233/U/ThO/sub 2/ - and the conventional recycle-mode uranium system - /sup 235/U/UO/sub 2/ : Pu/UO/sub 2/. The basic parameter varied was the fuel-to-moderator volume ratio (F/M) of the (uniform) lattice for the last core in each sequence. Although methods and data verification in the range of present interest, 0.5 (current lattices) < F/M < 4.0 are limited by the scarcity of experiments with F/M > 1.0, the EPRI-LEOPARD and LASER programs used for the thorium and uranium calculations, respectively, were successfully benchmarked against several of the more pertinent experiments.

  9. The solar core as never seen before

    Energy Technology Data Exchange (ETDEWEB)

    Eff-Darwich, A; Korzennik, S G, E-mail: adarwich@iac.es, E-mail: skorzennik@cfa.harvard.edu [Instituto de Astrofisica de Canarias (IAC), E-38200 La Laguna, Tenerife (Spain); Department de Edafologia y Geologia, Universidad de La Laguna (ULL), E-38206 La Laguna, Tenerife (Spain); Harvard-Smithsonian Center for Astrophysics, 60 Garden St. Cambridge, MA, 02138 (United States)

    2011-01-01

    One of the main drawbacks in the analysis of the dynamics of the solar core comes from the lack of consistent data sets that cover the low and intermediate degree range (l = 1,200). It is usually necessary to merge data obtained from different instruments and/or fitting methodologies and hence one introduces undesired systematic errors. In contrast, we present the results of analyzing MDI rotational splittings derived by a single fitting methodology applied to 4608-, 2304-, etc..., down to 182-day long time series. The direct comparison of these data sets and the analysis of the numerical inversion results have allowed us to constrain the dynamics of the solar core and to establish the accuracy of these data as a function of the length of the time-series.

  10. The Keys for Success: Leadership Core Competencies.

    Science.gov (United States)

    Pidgeon, Kristopher

    Providing leaders with skills resulting in positive behaviors, specifically increasing quality performance improvement projects and leadership style, ultimately may deliver an increase in professional development. Consisting of the topic leadership, this article consists of core competencies specifically targeted for learning leadership skills. The purpose of this article is to assist the leader with developing leadership skills, which promotes professional development. This article reviews leadership skills and describes in detail the elements of some core competencies that can enable the leader to develop skills, including strategic thinking, organizational skills, time management, decision-making, leadership skills, conflict resolution, and strategies to enhance performance improvement. The article provides the leader with insight and strategies to develop leadership skills, which can be invaluable to any leader, health care worker, or institution.

  11. .net core application lifecycle on Openshift

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    # .net core application lifecycle on Openshift I will show an example of a lifecycle of an OpenShift application with an emphasis on the continuous integration and deployment. The application compatible with [.net Standard](https://docs.microsoft.com/en-us/dotnet/standard/net-standard) can be easily deployed on OpenShift using [Source2Image](https://docs.openshift.com/enterprise/3.0/architecture/core_concepts/builds_and_image_streams.html#source-build) functionality, which doesn't require developers to maintain docker images of the application. I will also present how to efficiently integrate this feature into GitLab pipelines with an automated deployment of the "review" environment, as one its parts.

  12. MOX fuel arrangement for nuclear core

    Energy Technology Data Exchange (ETDEWEB)

    Kantrowitz, Mark L. (Portland, CT); Rosenstein, Richard G. (Windsor, CT)

    1998-01-01

    In order to use up a stockpile of weapons-grade plutonium, the plutonium is converted into a mixed oxide (MOX) fuel form wherein it can be disposed in a plurality of different fuel assembly types. Depending on the equilibrium cycle that is required, a predetermined number of one or more of the fuel assembly types are selected and arranged in the core of the reactor in accordance with a selected loading schedule. Each of the fuel assemblies is designed to produce different combustion characteristics whereby the appropriate selection and disposition in the core enables the resulting equilibrium cycle to closely resemble that which is produced using urania fuel. The arrangement of the MOX rods and burnable absorber rods within each of the fuel assemblies, in combination with a selective control of the amount of plutonium which is contained in each of the MOX rods, is used to tailor the combustion characteristics of the assembly.

  13. Mox fuel arrangement for nuclear core

    Energy Technology Data Exchange (ETDEWEB)

    Kantrowitz, Mark L. (Portland, CT); Rosenstein, Richard G. (Windsor, CT)

    2001-05-15

    In order to use up a stockpile of weapons-grade plutonium, the plutonium is converted into a mixed oxide (MOX) fuel form wherein it can be disposed in a plurality of different fuel assembly types. Depending on the equilibrium cycle that is required, a predetermined number of one or more of the fuel assembly types are selected and arranged in the core of the reactor in accordance with a selected loading schedule. Each of the fuel assemblies is designed to produce different combustion characteristics whereby the appropriate selection and disposition in the core enables the resulting equilibrium cycle to closely resemble that which is produced using urania fuel. The arrangement of the MOX rods and burnable absorber rods within each of the fuel assemblies, in combination with a selective control of the amount of plutonium which is contained in each of the MOX rods, is used to tailor the combustion. characteristics of the assembly.

  14. MOX fuel arrangement for nuclear core

    Energy Technology Data Exchange (ETDEWEB)

    Kantrowitz, Mark L. (Portland, CT); Rosenstein, Richard G. (Windsor, CT)

    2001-07-17

    In order to use up a stockpile of weapons-grade plutonium, the plutonium is converted into a mixed oxide (MOX) fuel form wherein it can be disposed in a plurality of different fuel assembly types. Depending on the equilibrium cycle that is required, a predetermined number of one or more of the fuel assembly types are selected and arranged in the core of the reactor in accordance with a selected loading schedule. Each of the fuel assemblies is designed to produce different combustion characteristics whereby the appropriate selection and disposition in the core enables the resulting equilibrium cycle to closely resemble that which is produced using urania fuel. The arrangement of the MOX rods and burnable absorber rods within each of the fuel assemblies, in combination with a selective control of the amount of plutonium which is contained in each of the MOX rods, is used to tailor the combustion characteristics of the assembly.

  15. MOX fuel arrangement for nuclear core

    Energy Technology Data Exchange (ETDEWEB)

    Kantrowitz, M.L.; Rosenstein, R.G.

    1998-10-13

    In order to use up a stockpile of weapons-grade plutonium, the plutonium is converted into a mixed oxide (MOX) fuel form wherein it can be disposed in a plurality of different fuel assembly types. Depending on the equilibrium cycle that is required, a predetermined number of one or more of the fuel assembly types are selected and arranged in the core of the reactor in accordance with a selected loading schedule. Each of the fuel assemblies is designed to produce different combustion characteristics whereby the appropriate selection and disposition in the core enables the resulting equilibrium cycle to closely resemble that which is produced using urania fuel. The arrangement of the MOX rods and burnable absorber rods within each of the fuel assemblies, in combination with a selective control of the amount of plutonium which is contained in each of the MOX rods, is used to tailor the combustion characteristics of the assembly. 38 figs.

  16. Differential Stoichiometry among Core Ribosomal Proteins

    Science.gov (United States)

    Slavov, Nikolai; Semrau, Stefan; Airoldi, Edoardo; Budnik, Bogdan; van Oudenaarden, Alexander

    2015-01-01

    Summary Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its dysregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some experiments suggest a more variable composition. Testing such variability requires direct and precise quantification of RPs. We used mass spectrometry to directly quantify RPs across monosomes and polysomes of mouse embryonic stem cells (ESC) and budding yeast. Our data show that the stoichiometry among core RPs in wild-type yeast cells and ESC depends both on the growth conditions and on the number of ribosomes bound per mRNA. Furthermore, we find that the fitness of cells with a deleted RP-gene is inversely proportional to the enrichment of the corresponding RP in polysomes. Together, our findings support the existence of ribosomes with distinct protein composition and physiological function. PMID:26565899

  17. Health services research doctoral core competencies

    Directory of Open Access Journals (Sweden)

    Holve Erin

    2009-06-01

    Full Text Available Abstract This manuscript presents an initial description of doctoral level core competencies for health services research (HSR. The competencies were developed by a review of the literature, text analysis of institutional accreditation self-studies submitted to the Council on Education for Public Health, and a consensus conference of HSR educators from US educational institutions. The competencies are described in broad terms which reflect the unique expertise, interests, and preferred learning methods of academic HSR programs. This initial set of core competencies is published to generate further dialogue within and outside of the US about the most important learning objectives and methods for HSR training and to clarify the unique skills of HSR training program graduates.

  18. Multi-Core Processor Memory Contention Benchmark Analysis Case Study

    Science.gov (United States)

    Simon, Tyler; McGalliard, James

    2009-01-01

    Multi-core processors dominate current mainframe, server, and high performance computing (HPC) systems. This paper provides synthetic kernel and natural benchmark results from an HPC system at the NASA Goddard Space Flight Center that illustrate the performance impacts of multi-core (dual- and quad-core) vs. single core processor systems. Analysis of processor design, application source code, and synthetic and natural test results all indicate that multi-core processors can suffer from significant memory subsystem contention compared to similar single-core processors.

  19. Antiresonant hollow core fiber with seven nested capillaries

    DEFF Research Database (Denmark)

    Antonio-Lopez, Jose E.; Habib, Selim; Van Newkirk, Amy

    2016-01-01

    We report an antiresonant hollow core fiber formed of 7 non-touching capillaries with inner tubes. The fiber has a core diameter of ∼33μm and a core wall of ∼780nm of thickness. We demonstrate robust single mode operation at 1064nm and broad transmission bandwidth.......We report an antiresonant hollow core fiber formed of 7 non-touching capillaries with inner tubes. The fiber has a core diameter of ∼33μm and a core wall of ∼780nm of thickness. We demonstrate robust single mode operation at 1064nm and broad transmission bandwidth....

  20. Crosstalk-Managed Heterogeneous Single-Mode 32-Core Fibre

    DEFF Research Database (Denmark)

    Sasaki, Y.; Fukumoto, Ryohei; Takenaga, Katsuhiro

    2016-01-01

    A heterogeneous single-mode 32-core fibre with a cladding diameter of 243 micrometer is designed and fabricated. The highest core count in single-mode multi-core fibres and low worst-case crosstalk of less than -24 dB/1000 km in C-band are achieved simultaneously.......A heterogeneous single-mode 32-core fibre with a cladding diameter of 243 micrometer is designed and fabricated. The highest core count in single-mode multi-core fibres and low worst-case crosstalk of less than -24 dB/1000 km in C-band are achieved simultaneously....

  1. Core stability in hedonic coalition formation

    OpenAIRE

    Woeginger, Gerhard J.

    2012-01-01

    In many economic, social and political situations individuals carry out activities in groups (coalitions) rather than alone and on their own. Examples range from households and sport clubs to research networks, political parties and trade unions. The underlying game theoretic framework is known as coalition formation. This survey discusses the notion of core stability in hedonic coalition formation (where each player's happiness only depends on the other members of his coalition but not on ho...

  2. GAMER with out-of-core computation

    OpenAIRE

    Schive, Hsi-Yu; Tsai, Yu-Chih; Chiueh, Tzihong

    2010-01-01

    GAMER is a GPU-accelerated Adaptive-MEsh-Refinement code for astrophysical simulations. In this work, two further extensions of the code are reported. First, we have implemented the MUSCL-Hancock method with the Roe's Riemann solver for the hydrodynamic evolution, by which the accuracy, overall performance and the GPU versus CPU speed-up factor are improved. Second, we have implemented the out-of-core computation, which utilizes the large storage space of multiple hard disks as the additional...

  3. Core Stabilization Exercise Prescription, Part 2

    OpenAIRE

    Brumitt, Jason; Matheson, J. W.; Meira, Erik P.

    2013-01-01

    Context Therapeutic exercises are frequently prescribed to patients with low back pain. Numerous exercise programs for patients with low back pain have been described. Many of these treatment programs are based on 1 of 2 popular rehabilitation strategies: a motor control exercise approach or a general exercise approach. Data Sources PubMed clinical queries from 1966 to March 2013 for keyword combinations including motor control exercise, core stability exercise, therapeutic exercise, general ...

  4. Validation of Core Temperature Estimation Algorithm

    Science.gov (United States)

    2016-01-29

    a constant heart rate until the CT estimate converges, with convergence defined as the time for CT to fall within 0.5% of the final temperature...range of error within which 95% of the estimated errors should fall assuming a normal distribution, which is consistent with the error distribution...and B.C. Ruby , "Core-Temperature Sensor Ingestion Timing and Measurement Variability," Jounral of Athletic Training, vol. 45, no. 6, pp. 594–600

  5. Core curriculum illustration: acute traumatic aortic injury.

    Science.gov (United States)

    Trevino, Manuel; Laks, Shaked; Brunner, Noemi

    2017-05-26

    This is the 34th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at http://www.aseronline.org/curriculum/toc.htm .

  6. New Literacies and the Common Core

    Science.gov (United States)

    Kist, William

    2013-01-01

    It makes sense that an emphasis on new ways of reading and writing fits easily within the Common Core umbrella. After all, a primary thrust of the new standards is college and career readiness. How can young people be prepared to thrive in today's society--in which people are connected 24 hours a day by media and coworkers may well live in…

  7. Making Mercury's Core with Light Elements

    Science.gov (United States)

    Vander Kaaden, Kathleen E.; McCubbin, Francis M.; Ross, D. Kent

    2016-01-01

    Recent results obtained from the MErcury Surface, Space ENvironment, GEochemistry, and Ranging spacecraft showed the surface of Mercury has low FeO abundances (less than 2 wt%) and high S abundances (approximately 4 wt%), suggesting the oxygen fugacity of Mercury's surface materials is somewhere between 3 to 7 log10 units below the IW buffer. The highly reducing nature of Mercury has resulted in a relatively thin mantle and a large core that has the potential to exhibit an exotic composition in comparison to the other terrestrial planets. This exotic composition may extend to include light elements (e.g., Si, C, S). Furthermore, has argued for a possible primary floatation crust on Mercury composed of graphite, which may require a core that is C-saturated. In order to investigate mercurian core compositions, we conducted piston cylinder experiments at 1 GPa, from 1300 C to 1700 C, using a range of starting compositions consisting of various Si-Fe metal mixtures (Si5Fe95, Si10Fe90, Si22Fe78, and Si35Fe65). All metals were loaded into graphite capsules used to ensure C-saturation during the duration of each experimental run. Our experiments show that Fe-Si metallic alloys exclude carbon relative to more Fe-rich metal. This exclusion of carbon commences within the range of 5 to 10 wt% Si. These results indicate that if Mercury has a Si-rich core (having more than approximately 5 wt% silicon), it would have saturated in carbon at low C abundances allowing for the possible formation of a graphite floatation crust as suggested by. These results have important implications for the thermal and magmatic evolution of Mercury.

  8. Explicit Instruction Elements in Core Reading Programs

    OpenAIRE

    Child, Angela R.

    2012-01-01

    Classroom teachers are provided instructional recommendations for teaching reading from their adopted core reading programs (CRPs). Explicit instruction elements or what is also called instructional moves, including direct explanation, modeling, guided practice, independent practice, discussion, feedback, and monitoring, were examined within CRP reading lessons. This study sought to answer the question: What elements of explicit instruction or instructional moves are included in the five most...

  9. SMA millimeter observations of hot molecular cores

    Energy Technology Data Exchange (ETDEWEB)

    Hernández-Hernández, Vicente; Zapata, Luis; Kurtz, Stan [Centro de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, Apdo. Postal 3-72 (Xangari), 58090 Morelia, Michoacán (Mexico); Garay, Guido, E-mail: v.hernandez@crya.unam.mx [Departamento de Astronomía, Universidad de Chile, Camino del Observatorio 1515, Las Condes, Santiago (Chile)

    2014-05-01

    We present Submillimeter Array observations in the 1.3 mm continuum and the CH{sub 3}CN (12 {sub K}-11 {sub K}) line of 17 hot molecular cores associated with young high-mass stars. The angular resolution of the observations ranges from 1.''0 to 4.''0. The continuum observations reveal large (>3500 AU) dusty structures with gas masses from 7 to 375 M {sub ☉}, which probably surround multiple young stars. The CH{sub 3}CN line emission is detected toward all the molecular cores at least up to the K = 6 component and is mostly associated with the emission peaks of the dusty objects. We used the multiple K-components of the CH{sub 3}CN and both the rotational diagram method and a simultaneous synthetic local thermodynamic equilibrium model with the XCLASS program to estimate the temperatures and column densities of the cores. For all sources, we obtained reasonable fits from XCLASS by using a model that combines two components: an extended and warm envelope and a compact hot core of molecular gas, suggesting internal heating by recently formed massive stars. The rotational temperatures lie in the range of 40-132 K and 122-485 K for the extended and compact components, respectively. From the continuum and CH{sub 3}CN results, we infer fractional abundances from 10{sup –9} to 10{sup –7} toward the compact inner components, which increase with the rotational temperature. Our results agree with a chemical scenario in which the CH{sub 3}CN molecule is efficiently formed in the gas phase above 100-300 K, and its abundance increases with temperature.

  10. Core curriculum illustration: blunt traumatic diaphragmatic hernia.

    Science.gov (United States)

    Fadl, Shaimaa Abdelhassib; Edwards, Rachael M

    2017-06-27

    This is the 43rd installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at: http://www.erad.org/page/CCIP_TOC .

  11. Core curriculum illustration: pediatric viral parotitis.

    Science.gov (United States)

    Pawley, Barbara; Rajendran, Sibi; Kondaveeti, Ramya

    2017-06-07

    This is the 36th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at http://www.aseronline.org/curriculum/toc.htm .

  12. Core curriculum illustration: invasive fungal sinusitis.

    Science.gov (United States)

    Desai, Khanant; Nunez, Diego B; Potter, Christopher A

    2017-12-01

    This is the 27th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at http://www.erad.org/?page=CCIP_TOC .

  13. Core curriculum illustration: dural venous sinus thrombosis.

    Science.gov (United States)

    Rajendran, Sibi; Pereira, Alex; Eckerd, Morgan; Pawley, Barbara

    2017-08-01

    This is the 25th installment of a series that will highlight one case per publication issue from the bank of cases available online as a part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for study online at http://www.aseronline.org/curriculum/toc.htm .

  14. Core Stabilization Exercise Prescription, Part I

    OpenAIRE

    Brumitt, Jason; Matheson, J. W.; Meira, Erik P.

    2013-01-01

    Context: Injury to the low back can cause significant pain and dysfunction, which can affect an athlete’s performance and result in time lost from sport. A common conservative treatment is therapeutic core stabilization exercises, which can address pain and musculoskeletal dysfunction in patients with low back pathology. Evidence Acquisition: MEDLINE and CINAHL were searched (from 1966 to March 2013) to identify relevant research. Keywords and keyword combinations searched included motor cont...

  15. Error Analysis of High Frequency Core Loss Measurement for Low-Permeability Low-Loss Magnetic Cores

    DEFF Research Database (Denmark)

    Niroumand, Farideh Javidi; Nymand, Morten

    2016-01-01

    in magnetic cores is B-H loop measurement where two windings are placed on the core under test. However, this method is highly vulnerable to phase shift error, especially for low-permeability, low-loss cores. Due to soft saturation and very low core loss, low-permeability low-loss magnetic cores are favorable...... in many of the high-efficiency high power-density power converters. Magnetic powder cores, among the low-permeability low-loss cores, are very attractive since they possess lower magnetic losses in compared to gapped ferrites. This paper presents an analytical study of the phase shift error in the core....... The analysis has been validated by experimental measurements for relatively low-loss magnetic cores with different permeability values....

  16. Dynamic musical communication of core affect.

    Science.gov (United States)

    Flaig, Nicole K; Large, Edward W

    2014-01-01

    Is there something special about the way music communicates feelings? Theorists since Meyer (1956) have attempted to explain how music could stimulate varied and subtle affective experiences by violating learned expectancies, or by mimicking other forms of social interaction. Our proposal is that music speaks to the brain in its own language; it need not imitate any other form of communication. We review recent theoretical and empirical literature, which suggests that all conscious processes consist of dynamic neural events, produced by spatially dispersed processes in the physical brain. Intentional thought and affective experience arise as dynamical aspects of neural events taking place in multiple brain areas simultaneously. At any given moment, this content comprises a unified "scene" that is integrated into a dynamic core through synchrony of neuronal oscillations. We propose that (1) neurodynamic synchrony with musical stimuli gives rise to musical qualia including tonal and temporal expectancies, and that (2) music-synchronous responses couple into core neurodynamics, enabling music to directly modulate core affect. Expressive music performance, for example, may recruit rhythm-synchronous neural responses to support affective communication. We suggest that the dynamic relationship between musical expression and the experience of affect presents a unique opportunity for the study of emotional experience. This may help elucidate the neural mechanisms underlying arousal and valence, and offer a new approach to exploring the complex dynamics of the how and why of emotional experience.

  17. Growth of Necrotic Cores in Vulnerable Plaque

    Science.gov (United States)

    Fok, Pak-Wing

    2011-03-01

    Plaques are fatty deposits that grow mainly in arteries and develop as a result of a chronic inflammatory response. Plaques are called vulnerable when they are prone to mechanical rupture. Vulnerable Plaques (VPs) are characterized by lipid-rich, necrotic cores that are heavily infiltrated with macrophages. The rupture of VPs releases thrombogenic agents into the bloodstream, usually resulting in myocardial infarctions. We propose a quantitative model to predict the development of a plaque's necrotic core. By solving coupled reaction-diffusion equations for macrophages and dead cells, we explore the joint effects of hypoxic cell death and chemo-attraction to Ox-LDL, a molecule that is strongly linked to atherosclerosis. Our model predicts cores that have approximately the right size and shape. Normal mode analysis and subsequent calculation of the smallest eigenvalues allow us to compute the times required for the system to reach its steady state. This study allows us to make quantitative predictions for how quickly vulnerable plaques develop and how their growth depends on system parameters such as chemotactic coefficients and cell death rates.

  18. Information professionals: core competencies and professional development

    Directory of Open Access Journals (Sweden)

    Flávia Ferreira

    2007-01-01

    Full Text Available Introduction. We discuss the concept of core competencies applied to policies for teaching and training information professionals, particularly librarians. Method. Sixty graduates of the Institute were employed as information professionals. These sixty were asked to attribute degrees of importance to specific items associated with knowledge and skills that, within the scope of this research, were considered core competencies for meeting the demands of their jobs. Participants were also asked to cite knowledge they acquired in school and knowledge they use in exercising their profession, the skills that they consider necessary but that they did not gain in school, and the difficulties they encounter in exercising their profession and for which they were not sufficiently well prepared. Analysis. Both quantitative and qualitative data analyses were performed. The data were tabulated using Access and several reports and cross-tabulations were generated. Results. The results suggest a gulf between knowledge and skills acquired in library school and those that are required by the job market. In particular, participants lacked the skills they needed to work with information and communication technologies. Conclusion. The concept of core competencies is increasingly taken into account by the productive sector of the economy. The educational system ought to keep up with this change. The empirical research described shows that there is a need to establish advanced and modern policies for the education of librarians, participants in the market for information professionals.

  19. Essential ingredients in core-collapse supernovae

    Directory of Open Access Journals (Sweden)

    W. Raphael Hix

    2014-03-01

    Full Text Available Carrying 1044 joules of kinetic energy and a rich mix of newly synthesized atomic nuclei, core-collapse supernovae are the preeminent foundries of the nuclear species which make up our solar system and ourselves. Signaling the inevitable death of a massive star, and the birth of a neutron star or black hole, core-collapse supernovae combine physics over a wide range in spatial scales, from kilometer-sized hydrodynamic motions (eventually growing to gigameter scale down to femtometer-scale nuclear reactions. We will discuss our emerging understanding of the convectively-unstable, neutrino-driven explosion mechanism, based on increasingly realistic neutrino radiation hydrodynamic simulations that include progressively better nuclear and particle physics. Multi-dimensional models with spectral neutrino transport from several research groups, which slowly develop successful explosions for a range of progenitors, have recently motivated changes in our understanding of the neutrino reheating mechanism. In a similar fashion, improvements in nuclear physics, most notably explorations of weak interactions on nuclei and the nuclear equation of state, continue to refine our understanding of the births of neutron stars and the supernovae that result. Recent progress on both the macroscopic and microscopic effects that affect core-collapse supernovae are discussed.

  20. [Essential professional core competencies for nurses].

    Science.gov (United States)

    Chen, Yu-Chih

    2010-10-01

    Core competency is vital to the nursing profession. Such helps guarantee the high quality and effectiveness of delivered care and maintains the social value and status of the nursing profession. This article introduces the definition of nursing core competency and its connotations. The core competency profile for the nursing profession embraces basic behavioral attributes as well as mastery of advanced practice skills. The former include such attributes as gentleness, willingness to serve, keen observation and judgment, efficiency, skillfulness, responsibility and accountability. The latter embraces skills in general care, communication and collaboration, management, self-development, innovation and research, and stress-adjustment. To cultivate competent nurses, academic education should emphasize critical thinking skills, integrate problem-based and evidence-based learning approaches into curricula, and use objective structured clinical examination to evaluate learning outcomes. In the healthcare sector, systematic professional training models such as the clinical ladder with multidiscipline rotation hold the potential to train novice nurses as expert professionals. Meanwhile, to advance the professional capabilities of nurses, nursing administrators should provide a positive work environment to fuel and maintain learning motivation. Education and healthcare systems should work closely together to promote the professional competence of nurses and to strengthen the value of the nursing profession.

  1. Uncovering the information core in recommender systems.

    Science.gov (United States)

    Zeng, Wei; Zeng, An; Liu, Hao; Shang, Ming-Sheng; Zhou, Tao

    2014-08-21

    With the rapid growth of the Internet and overwhelming amount of information that people are confronted with, recommender systems have been developed to effectively support users' decision-making process in online systems. So far, much attention has been paid to designing new recommendation algorithms and improving existent ones. However, few works considered the different contributions from different users to the performance of a recommender system. Such studies can help us improve the recommendation efficiency by excluding irrelevant users. In this paper, we argue that in each online system there exists a group of core users who carry most of the information for recommendation. With them, the recommender systems can already generate satisfactory recommendation. Our core user extraction method enables the recommender systems to achieve 90% of the accuracy of the top-L recommendation by taking only 20% of the users into account. A detailed investigation reveals that these core users are not necessarily the large-degree users. Moreover, they tend to select high quality objects and their selections are well diversified.

  2. Uncovering the information core in recommender systems

    Science.gov (United States)

    Zeng, Wei; Zeng, An; Liu, Hao; Shang, Ming-Sheng; Zhou, Tao

    2014-08-01

    With the rapid growth of the Internet and overwhelming amount of information that people are confronted with, recommender systems have been developed to effectively support users' decision-making process in online systems. So far, much attention has been paid to designing new recommendation algorithms and improving existent ones. However, few works considered the different contributions from different users to the performance of a recommender system. Such studies can help us improve the recommendation efficiency by excluding irrelevant users. In this paper, we argue that in each online system there exists a group of core users who carry most of the information for recommendation. With them, the recommender systems can already generate satisfactory recommendation. Our core user extraction method enables the recommender systems to achieve 90% of the accuracy of the top-L recommendation by taking only 20% of the users into account. A detailed investigation reveals that these core users are not necessarily the large-degree users. Moreover, they tend to select high quality objects and their selections are well diversified.

  3. Core Muscle Activation in Suspension Training Exercises.

    Science.gov (United States)

    Cugliari, Giovanni; Boccia, Gennaro

    2017-02-01

    A quantitative observational laboratory study was conducted to characterize and classify core training exercises executed in a suspension modality on the base of muscle activation. In a prospective single-group repeated measures design, seventeen active male participants performed four suspension exercises typically associated with core training (roll-out, bodysaw, pike and knee-tuck). Surface electromyographic signals were recorded from lower and upper parts of rectus abdominis, external oblique, internal oblique, lower and upper parts of erector spinae muscles using concentric bipolar electrodes. The average rectified values of electromyographic signals were normalized with respect to individual maximum voluntary isometric contraction of each muscle. Roll-out exercise showed the highest activation of rectus abdominis and oblique muscles compared to the other exercises. The rectus abdominis and external oblique reached an activation higher than 60% of the maximal voluntary contraction (or very close to that threshold, 55%) in roll-out and bodysaw exercises. Findings from this study allow the selection of suspension core training exercises on the basis of quantitative information about the activation of muscles of interest. Roll-out and bodysaw exercises can be considered as suitable for strength training of rectus abdominis and external oblique muscles.

  4. Thermal Hydraulic Tests for Reactor Core Safety

    Energy Technology Data Exchange (ETDEWEB)

    Moon, S. K.; Baek, W. P.; Chun, S. Y. (and others)

    2007-06-15

    The main objectives of the present project are to resolve the current issues of reactor core thermal hydraulics, to develop an advanced measurement and analytical techniques, and to perform reactor core safety verification tests. 6x6 reflood experiments, various heat transfer experiments using Freon, and experiments on the spacer grids effects on the post-dryout are carried out using spacer grids developed in Korea in order to resolve the current issues of the reactor core thermal hydraulics. In order to develop a reflood heat transfer model, the detailed reflood phenomena are visualized and measured using round tube and 2x2 rod bundle. A detailed turbulent mixing phenomenon for subchannels is measured using advanced measurement techniques such as LDV and PIV. MARS and MATRA codes developed in Korea are assessed, verified and improved using the obtained experimental data. Finally, a systematic quality assurance program and experimental data generation system has been constructed in order to increase the reliability of the experimental data.

  5. Dynamic Musical Communication of Core Affect

    Directory of Open Access Journals (Sweden)

    Nicole eFlaig

    2014-03-01

    Full Text Available Is there something special about the way music communicates feelings? Theorists since Meyer (1956 have attempted to explain how music could stimulate varied and subtle affective experiences by violating learned expectancies, or by mimicking other forms of social interaction. Our proposal is that music speaks to the brain in its own language; it need not imitate any other form of communication. We review recent theoretical and empirical literature, which suggests that all conscious processes consist of dynamic neural events, produced by spatially dispersed processes in the physical brain. Intentional thought and affective experience arise as dynamical aspects of neural events taking place in multiple brain areas simultaneously. At any given moment, this content comprises a unified scene that is integrated into a dynamic core through synchrony of neuronal oscillations. We propose that 1 neurodynamic synchrony with musical stimuli gives rise to musical qualia including tonal and temporal expectancies, and that 2 music-synchronous responses couple into core neurodynamics, enabling music to directly modulate core affect. Expressive music performance, for example, may recruit rhythm-synchronous neural responses to support affective communication. We suggest that the dynamic relationship between musical expression and the experience of affect presents a unique opportunity for the study of emotional experience. This may help elucidate the neural mechanisms underlying arousal and valence, and offer a new approach to exploring the complex dynamics of the how and why of emotional experience.

  6. Children's science learning: A core skills approach.

    Science.gov (United States)

    Tolmie, Andrew K; Ghazali, Zayba; Morris, Suzanne

    2016-09-01

    Research has identified the core skills that predict success during primary school in reading and arithmetic, and this knowledge increasingly informs teaching. However, there has been no comparable work that pinpoints the core skills that underlie success in science. The present paper attempts to redress this by examining candidate skills and considering what is known about the way in which they emerge, how they relate to each other and to other abilities, how they change with age, and how their growth may vary between topic areas. There is growing evidence that early-emerging tacit awareness of causal associations is initially separated from language-based causal knowledge, which is acquired in part from everyday conversation and shows inaccuracies not evident in tacit knowledge. Mapping of descriptive and explanatory language onto causal awareness appears therefore to be a key development, which promotes unified conceptual and procedural understanding. This account suggests that the core components of initial science learning are (1) accurate observation, (2) the ability to extract and reason explicitly about causal connections, and (3) knowledge of mechanisms that explain these connections. Observational ability is educationally inaccessible until integrated with verbal description and explanation, for instance, via collaborative group work tasks that require explicit reasoning with respect to joint observations. Descriptive ability and explanatory ability are further promoted by managed exposure to scientific vocabulary and use of scientific language. Scientific reasoning and hypothesis testing are later acquisitions that depend on this integration of systems and improved executive control. © 2016 The British Psychological Society.

  7. SMART core preliminary nuclear design-II

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Chan; Ji, Seong Kyun; Chang, Moon Hee

    1997-06-01

    Three loading patterns for 330 MWth SMART core are constructed for 25, 33 and 29 CRDMs, and one loading pattern for larger 69-FA core with 45 CRDMs is also constructed for comparison purpose. In this study, the core consists of 57 reduced height Korean Optimized Fuel Assemblies (KOFAs) developed by KAERI. The enrichment of fuel is 4.95 w/o. As a main burnable poison, 35% B-10 enriched B{sub 4}C-Al{sub 2}O{sub 3} shim is used. To control stuck rod worth, some gadolinia bearing fuel rods are used. The U-235 enrichment of the gadolinia bearing fuel rods is 1.8 w/o as used in KOFA. All patterns return cycle length of about 3 years. Three loading patterns except 25-CRDM pattern satisfy cold shutdown condition of keff {<=} 0.99 without soluble boron. These three patterns also satisfy the refueling condition of keff {<=} 0.95. In addition to the construction of loading pattern, an editing module of MASTER PPI files for rod power history generation is developed and rod power histories are generated for 29-CRDM loading pattern. Preliminary Fq design limit is suggested as 3.71 based on KOFA design experience. (author). 9 tabs., 45 figs., 16 refs.

  8. Activation of Selected Core Muscles during Pressing

    Directory of Open Access Journals (Sweden)

    Thomas W. Nesser

    2015-10-01

    Full Text Available Introduction: Unstable surface training is often used to activate core musculature during resistance training. Unfortunately, unstable surface training is risky and leads to detraining. Purpose: The purpose of this study was to determine core muscle activation during stable surface ground-based lifts. Methods: Fourteen recreational trained and former NCAA DI athletes (weight 84.2 ± 13.3 kg; height 176.0 ± 9.5 cm; age 20.9 ± 2.0 years volunteered for participation. Subjects completed two ground-based lifts: overhead press and push-press. Surface EMG was recorded from 4 muscles on the right side of the body (Rectus Abdominus (RA, External Oblique (EO, Transverse Abdominus (TA, and Erector Spinae (ES. Results: Paired sample T-tests identified significant muscle activation differences between the overhead press and the push-press included ES and EO. Average and peak EMG for ES was significantly greater in push-press (P<0.01. Anterior displacement of COP was significantly greater in push-press compared to overhead press during the eccentric phase. Conclusion: The push-press was identified as superior in core muscle activation when compared to the overhead pressing exercise. Keywords: torso, stability, weight lifting, resistance training

  9. Data preparation for CORE system in a MEBES environment

    Science.gov (United States)

    Lin, Ming-Huei

    1994-11-01

    Early in 1993 a CORE-2564 was installed in Taiwan Mask Corporation (TMC). This was in addition to the two existing MEBES-III systems. We have developed a data preparation system which we call `PRE-CORE' to integrate the CORE system into our existing MEBES-based environment. This PRE-CORE system consists of a high speed workstation and CATS software, supplied by Transcription Enterprises Limited. The system links CORE-2564 and the original data processing computer through the Ethernet network. The data files are converted by the PRE-CORE system into a simpler format for CORE to handle. The time spent in data preparation in the CORE system is significantly reduced, and therefore more time is available for plate-writing. Furthermore, due to this simpler data format, CORE can write masks in precise address units faster than was previously possible, regardless of whether or not the patterns are scaled. This helps produce high quality reticles while at the same time enhancing turn around time. However, in the first stage the TMC lithographic process bias remains the same for both MEBES and CORE plates. In this paper, the PRE-CORE data treatment methodology will be described. The benefits of using PRE-CORE will be compared to results achieved without the pre-processing of PRE-CORE.

  10. Lightweight Low Force Rotary Percussive Coring Tool for Planetary Applications

    Science.gov (United States)

    Hironaka, Ross; Stanley, Scott

    2010-01-01

    A prototype low-force rotary-percussive rock coring tool for use in acquiring samples for geological surveys in future planetary missions was developed. The coring tool could eventually enable a lightweight robotic system to operate from a relatively small (less than 200 kg) mobile or fixed platform to acquire and cache Mars or other planetary rock samples for eventual return to Earth for analysis. To gain insight needed to design an integrated coring tool, the coring ability of commercially available coring bits was evaluated for effectiveness of varying key parameters: weight-on-bit, rotation speed, percussive rate and force. Trade studies were performed for different methods of breaking a core at its base and for retaining the core in a sleeve to facilitate sample transfer. This led to a custom coring tool design which incorporated coring, core breakage, core retention, and core extraction functions. The coring tool was tested on several types of rock and demonstrated the overall feasibility of this approach for robotic rock sample acquisition.

  11. Apollo rocks, fines and soil cores

    Science.gov (United States)

    Allton, J.; Bevill, T.

    Apollo rocks and soils not only established basic lunar properties and ground truth for global remote sensing, they also provided important lessons for planetary protection (Adv. Space Res ., 1998, v. 22, no. 3 pp. 373-382). The six Apollo missions returned 2196 samples weighing 381.7 kg, comprised of rocks, fines, soil cores and 2 gas samples. By examining which samples were allocated for scientific investigations, information was obtained on usefulness of sampling strategy, sampling devices and containers, sample types and diversity, and on size of sample needed by various disciplines. Diversity was increased by using rakes to gather small rocks on the Moon and by removing fragments >1 mm from soils by sieving in the laboratory. Breccias and soil cores are diverse internally. Per unit weight these samples were more often allocated for research. Apollo investigators became adept at wringing information from very small sample sizes. By pushing the analytical limits, the main concern was adequate size for representative sampling. Typical allocations for trace element analyses were 750 mg for rocks, 300 mg for fines and 70 mg for core subsamples. Age-dating and isotope systematics allocations were typically 1 g for rocks and fines, but only 10% of that amount for core depth subsamples. Historically, allocations for organics and microbiology were 4 g (10% for cores). Modern allocations for biomarker detection are 100mg. Other disciplines supported have been cosmogenic nuclides, rock and soil petrology, sedimentary volatiles, reflectance, magnetics, and biohazard studies . Highly applicable to future sample return missions was the Apollo experience with organic contamination, estimated to be from 1 to 5 ng/g sample for Apollo 11 (Simonheit &Flory, 1970; Apollo 11, 12 &13 Organic contamination Monitoring History, U.C. Berkeley; Burlingame et al., 1970, Apollo 11 LSC , pp. 1779-1792). Eleven sources of contaminants, of which 7 are applicable to robotic missions, were

  12. Nitrogen partitioning during core-mantle differentiation

    Science.gov (United States)

    Speelmanns, I. M.; Schmidt, M. W.; Liebske, C.

    2016-12-01

    This study investiagtes nitrogen partitioing between metal and silicate melts as relevant for core segregation during the accretion of planetesimals into the Earth. On present day Earth, N belongs to the most important elements, as it is one of the key constituents of our atmosphere and forms the basis of life. However, the geochemistry of N, i.e. its distribution and isotopic fractionation between Earth's deep reservoirs is not well constrained. In order to determine the partitioning behaviour of N, a centrifuging piston cylinder was used to euqilibrate and then gravitationally separate metal-silicate melt pairs at 1250 °C, 1 GPa over the range of oxygen fugacities thought to have prevailied druing core segreagtion (IW-4 to IW). Complete segregation of the two melts was reached within 3 hours at 1000 g, the interface showing a nice meniscus The applied double capsule technique, using an outer metallic and inner non-metallic (mostly graphite) capsule, minimizes volatile loss over the course of the experiment compared to single non-metallic capsules. The two quenched melts were cut apart, cleaned at the outside and N concentrations of the melts were analysed on bulk samples by an elemental analyser. Nevertheless, the low amount of sample material and the N yield in the high pressure experiments required the developement of new analytical routines. Despite these experimental and analytical difficulties, we were able to determine a DNmetal/silicateof 13±0.25 at IW-1, N partitioning into the core froming metal. The few availible literature data [1],[2] suggest that N changes its compatibility favoring the silicate melt or magma ocean at around IW-2.5. In order to asses how much N may effectively be contained in the core and the silicate Earth, experiments characterizing N behaviour over the entire range of core formation condtitions are well under way. [1] Kadik et al., (2011) Geochemistry International 49.5: 429-438. [2] Roskosz et al., (2013) GCA 121: 15-28.

  13. Core Health Outcomes In Childhood Epilepsy (CHOICE): protocol for the selection of a core outcome set.

    Science.gov (United States)

    Morris, Christopher; Dunkley, Colin; Gibbon, Frances M; Currier, Janet; Roberts, Deborah; Rogers, Morwenna; Crudgington, Holly; Bray, Lucy; Carter, Bernie; Hughes, Dyfrig; Tudur Smith, Catrin; Williamson, Paula R; Gringras, Paul; Pal, Deb K

    2017-11-28

    There is increasing recognition that establishing a core set of outcomes to be evaluated and reported in trials of interventions for particular conditions will improve the usefulness of health research. There is no established core outcome set for childhood epilepsy. The aim of this work is to select a core outcome set to be used in evaluative research of interventions for children with rolandic epilepsy, as an exemplar of common childhood epilepsy syndromes. First we will identify what outcomes should be measured; then we will decide how to measure those outcomes. We will engage relevant UK charities and health professional societies as partners, and convene advisory panels for young people with epilepsy and parents of children with epilepsy. We will identify candidate outcomes from a search for trials of interventions for childhood epilepsy, statutory guidance and consultation with our advisory panels. Families, charities and health, education and neuropsychology professionals will be invited to participate in a Delphi survey following recommended practices in the development of core outcome sets. Participants will be able to recommend additional outcome domains. Over three rounds of Delphi survey participants will rate the importance of candidate outcome domains and state the rationale for their decisions. Over the three rounds we will seek consensus across and between families and health professionals on the more important outcomes. A face-to-face meeting will be convened to ratify the core outcome set. We will then review and recommend ways to measure the shortlisted outcomes using clinical assessment and/or patient-reported outcome measures. Our methodology is a proportionate and pragmatic approach to expediently produce a core outcome set for evaluative research of interventions aiming to improve the health of children with epilepsy. A number of decisions have to be made when designing a study to develop a core outcome set including defining the scope

  14. Preparation of bilayer-core osmotic pump tablet by coating the indented core tablet.

    Science.gov (United States)

    Liu, Longxiao; Xu, Xiangning

    2008-03-20

    In this paper, a bilayer-core osmotic pump tablet (OPT) which does not require laser drilling to form the drug delivery orifice is described. The bilayer-core consisted of two layers: (a) push layer and (b) drug layer, and was made with a modified upper tablet punch, which produced an indentation at the center of the drug layer surface. The indented tablets were coated by using a conventional pan-coating process. Although the bottom of the indentation could be coated, the side face of the indentation was scarcely sprayed by the coating solution and this part of the tablet remained at least partly uncoated leaving an aperture from which drug release could occur. Nifedipine was selected as the model drug. Sodium chloride was used as osmotic agent, polyvinylpyrrolidone as suspending agent and croscarmellose sodium as expanding agent. The indented core tablet was coated by ethyl cellulose as semipermeable membrane containing polyethylene glycol 400 for controlling the membrane permeability. The formulation of core tablet was optimized by orthogonal design and the release profiles of various formulations were evaluated by similarity factor (f(2)). It was found that the optimal OPT was able to deliver nifedipine at an approximate zero-order up to 24 h, independent on both release media and agitation rates. The preparation of bilayer-core OPT was simplified by coating the indented core tablet, by which sophisticated technology of the drug layer identification and laser drilling could be eliminated. It might be promising in the field of preparation of bilayer-core OPT.

  15. NanoDrill: 1 Actuator Core Acquisition System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to design, build and test a 1 kg, single actuator, sample acquisition drill. The drill uses a novel method of core or powder acquisition. The core...

  16. 34 CFR 300.10 - Core academic subjects.

    Science.gov (United States)

    2010-07-01

    ... DISABILITIES General Definitions Used in This Part § 300.10 Core academic subjects. Core academic subjects means English, reading or language arts, mathematics, science, foreign languages, civics and government...

  17. Core stability training on lower limb balance strength.

    Science.gov (United States)

    Dello Iacono, Antonio; Padulo, Johnny; Ayalon, Moshe

    2016-01-01

    This study aimed to assess the effects of core stability training on lower limbs' muscular asymmetries and imbalances in team sport. Twenty footballers were divided into two groups, either core stability or control group. Before each daily practice, core stability group (n = 10) performed a core stability training programme, while control group (n = 10) did a standard warm-up. The effects of the core stability training programme were assessed by performing isokinetic tests and single-leg countermovement jumps. Significant improvement was found for knee extensors peak torque at 3.14 rad · s(-1) (14%; P core stability group. The jump tests showed a significant reduction in the strength asymmetries in core stability group (-71.4%; P = 0.02) while a concurrent increase was seen in the control group (33.3%; P core exercises for optimal lower limbs strength balance development in young soccer players.

  18. Dual hollow-core anti-resonant fibres

    Science.gov (United States)

    Wheeler, N. V.; Bradley, T. D.; Hayes, J. R.; Jasion, G. T.; Chen, Y.; Sandoghchi, S. R.; Horak, P.; Poletti, F.; Petrovich, M. N.; Richardson, D. J.

    2016-04-01

    While hollow core-photonic crystal fibres are now a well-established fibre technology, the majority of work on these speciality fibres has been on designs with a single core for optical guidance. In this paper we present the first dual hollow-core anti-resonant fibres (DHC-ARFs). The fibres have high structural uniformity and low loss (minimum loss of 0.5 dB/m in the low loss guidance window) and demonstrate regimes of both inter-core coupling and zero coupling, dependent on the wavelength of operation, input polarisation, core separation and bend radius. In a DHC-ARF with a core separation of 4.3 μm, we find that with an optimised input polarisation up to 65% of the light guided in the launch core can be coupled into the second core, opening up applications in power delivery, gas sensing and quantum optics.

  19. Core and Dynamo Evolution in Small Solar System Bodies

    Science.gov (United States)

    Scheinberg, A.; Elkins-Tanton, L. T.; Schubert, G.

    2013-10-01

    We produce a core solidification timeline and core chemical profile for planetesimals, then explore the potential strength and longevity of a dynamo. Different sulfur content and adiabat slope may create a dynamo qualitatively different than Earth's.

  20. Sandwich Structure Based On Corrugated-Core: A Review

    Directory of Open Access Journals (Sweden)

    Zaid N. Z. M.

    2016-01-01

    Full Text Available Sandwich structures are commonly based on polymeric foam and honeycomb core material, for use in lightweight applications such as fuselage in aero plane, hull in marine construction and others. A review of sandwich structure based on corrugated-core is proposed and presented in this paper. Firstly, this paper aims to provide a means of comparing available sandwich structure in industries. Secondly, this paper aims to provide sandwich structure with corrugated-core for future research development efforts in field of sandwich construction. This paper starts with introduction of composite material such as sandwich structure, the advantages of sandwich structure was shown. After that these papers provide the structure of sandwich structure which includes the two faces and the cores. Furthermore, sandwich structure with different cores, which is honeycomb, foam core and corrugated core are discussed. At the end, the paper discussed more on corrugated-core for future research development.

  1. WAIS Divide Ice Core Images, Antarctica, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set is comprised of optical images of ice core sections, acquired with a digital line-scan camera in the cold room facility at the U.S. National Ice Core...

  2. Straight studs from southern pine veneer cores and cordwood

    Science.gov (United States)

    Peter Koch

    1968-01-01

    An economically feasible system has been developed for converting southern pine veneer cores into straight 8-foot studs (2). Prototype studs - two per core - were 100 percent SPIB stud grade and better.

  3. Transmission properties of hollow-core photonic bandgap fibers

    DEFF Research Database (Denmark)

    Falk, Charlotte Ijeoma; Hald, Jan; Petersen, Jan C.

    2010-01-01

    Variations in optical transmission of four types of hollow-core photonic bandgap fibers are measured as a function of laser frequency. These variations influence the potential accuracy of gas sensors based on molecular spectroscopy in hollow-core fibers.......Variations in optical transmission of four types of hollow-core photonic bandgap fibers are measured as a function of laser frequency. These variations influence the potential accuracy of gas sensors based on molecular spectroscopy in hollow-core fibers....

  4. A NOTE ON CHARACTERIZING CORE STABILITY WITH FUZZY GAMES

    OpenAIRE

    EVAN SHELLSHEAR

    2011-01-01

    This paper investigates core stability of cooperative (TU) games via a fuzzy extension of the totally balanced cover of a cooperative game. The stability of the core of the fuzzy extension of a game, the concave extension, is shown to reflect the core stability of the original game and vice versa. Stability of the core is then shown to be equivalent to the existence of an equilibrium of a certain correspondence.

  5. High-density multicore fiber with heterogeneous core arrangement

    DEFF Research Database (Denmark)

    Amma, Y.; Sasaki, Y.; Takenaga, K.

    2015-01-01

    A 30-core fiber with heterogeneous cores that achieved large spatial multiplicity and low crosstalk of less than −40 dB at 100 km was demonstrated. The correlation lengths were estimated to be more than 1 m.......A 30-core fiber with heterogeneous cores that achieved large spatial multiplicity and low crosstalk of less than −40 dB at 100 km was demonstrated. The correlation lengths were estimated to be more than 1 m....

  6. Open core control software for surgical robots.

    Science.gov (United States)

    Arata, Jumpei; Kozuka, Hiroaki; Kim, Hyung Wook; Takesue, Naoyuki; Vladimirov, B; Sakaguchi, Masamichi; Tokuda, Junichi; Hata, Nobuhiko; Chinzei, Kiyoyuki; Fujimoto, Hideo

    2010-05-01

    In these days, patients and doctors in operation room are surrounded by many medical devices as resulting from recent advancement of medical technology. However, these cutting-edge medical devices are working independently and not collaborating with each other, even though the collaborations between these devices such as navigation systems and medical imaging devices are becoming very important for accomplishing complex surgical tasks (such as a tumor removal procedure while checking the tumor location in neurosurgery). On the other hand, several surgical robots have been commercialized, and are becoming common. However, these surgical robots are not open for collaborations with external medical devices in these days. A cutting-edge "intelligent surgical robot" will be possible in collaborating with surgical robots, various kinds of sensors, navigation system and so on. On the other hand, most of the academic software developments for surgical robots are "home-made" in their research institutions and not open to the public. Therefore, open source control software for surgical robots can be beneficial in this field. From these perspectives, we developed Open Core Control software for surgical robots to overcome these challenges. In general, control softwares have hardware dependencies based on actuators, sensors and various kinds of internal devices. Therefore, these control softwares cannot be used on different types of robots without modifications. However, the structure of the Open Core Control software can be reused for various types of robots by abstracting hardware dependent parts. In addition, network connectivity is crucial for collaboration between advanced medical devices. The OpenIGTLink is adopted in Interface class which plays a role to communicate with external medical devices. At the same time, it is essential to maintain the stable operation within the asynchronous data transactions through network. In the Open Core Control software, several

  7. A suspended core nanofiber with unprecedented large diameter ratio of holey region to core.

    Science.gov (United States)

    Liao, Meisong; Chaudhari, Chitrarekha; Yan, Xin; Qin, Guanshi; Kito, Chihiro; Suzuki, Takenobu; Ohishi, Yasutake

    2010-04-26

    For a suspended core nanofiber, the holey region is expected to be as large as possible to propagate the light at wavelengths as long as possible. Additionally, a large holey region is significant for its applications in sensors. However, the fabrication of nanofiber with large holey region is still a challenge so far. In this paper a method, which involves pumping positive pressure of nitrogen gas in both the cane fabrication and fiber-drawing processes, was proposed. A suspended core nanofiber, with a core diameter of around 480 nm and an unprecedented diameter ratio of holey region to core (DRHC) of at least 62, was fabricated in the length of several hundred meters. Owing to the large holey region, the confinement loss of the suspended core nanofiber is insignificant when the wavelength of light propagated in it is 1700 nm. For this fabrication technique, the nanowire length, fabrication efficiency, and the uniformity in the diameter are much superior to those of the nanowires fabricated in other ways. Finally, single mode third harmonic generation was observed by this nanofiber under the pump of a 1557 nm femtosecond fiber laser. This work shows the prospect of fabrication of nanostructured waveguide in glass materials by an inflation technique.

  8. A HYBRID GENETIC ALGORITHM-NEURAL NETWORK APPROACH FOR PRICING CORES AND REMANUFACTURED CORES

    Directory of Open Access Journals (Sweden)

    M. Seidi

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT:Sustainability has become a major issue in most economies, causing many leading companies to focus on product recovery and reverse logistics. Remanufacturing is an industrial process that makes used products reusable. One of the important aspects in both reverse logistics and remanufacturing is the pricing of returned and remanufactured products (called cores. In this paper, we focus on pricing the cores and remanufactured cores. First we present a mathematical model for this purpose. Since this model does not satisfy our requirements, we propose a simulation optimisation approach. This approach consists of a hybrid genetic algorithm based on a neural network employed as the fitness function. We use automata learning theory to obtain the learning rate required for training the neural network. Numerical results demonstrate that the optimal value of the acquisition price of cores and price of remanufactured cores is obtained by this approach.

    AFRIKAANSE OPSOMMING: Volhoubaarheid het ‘n belangrike saak geword in die meeste ekonomieë, wat verskeie maatskappye genoop het om produkherwinning en omgekeerde logistiek te onder oë te neem. Hervervaardiging is ‘n industriële proses wat gebruikte produkte weer bruikbaar maak. Een van die belangrike aspekte in beide omgekeerde logistiek en hervervaardiging is die prysbepaling van herwinne en hervervaardigde produkte. Hierdie artikel fokus op die prysbepalingsaspekte by wyse van ‘n wiskundige model.

  9. Core Content for the Subspecialty of Clinical Informatics

    OpenAIRE

    Gardner, Reed M.; Overhage, J. Marc; Steen, Elaine B.; Munger, Benson S.; Holmes, John H.; Williamson, Jeffrey J.; Detmer, Don E.

    2009-01-01

    The Core Content for Clinical Informatics defines the boundaries of the discipline and informs the Program Requirements for Fellowship Education in Clinical Informatics. The Core Content includes four major categories: fundamentals, clinical decision making and care process improvement, health information systems, and leadership and management of change. The AMIA Board of Directors approved the Core Content for Clinical Informatics in November 2008.

  10. Core concepts of law: taking common-sense seriously

    NARCIS (Netherlands)

    Breuker, J.A.P.J.; Hoekstra, R.J.

    2004-01-01

    In this paper we present LRI-Core, a core ontology for covering domains of law. After a decade of developing many ontologies for legal domains and applications, the need for a unifying core ontology that covers the main concepts that are common to all legal domains became very apparent. It can be

  11. The Use of Flexible Staffing Arrangements in Core Production Jobs.

    Science.gov (United States)

    Gramm, Cynthia L.; Schnell, John F.

    2001-01-01

    A 1994-96 survey of Alabama human resource managers indicated that unions deterred the use of flexible arrangements; subcontracting was positively related to core employees' wages; and flexible staffing was associated with core employee hiring costs and low-cost production strategies. Core employees gained job security through use of flexible…

  12. On the effective parallel programming of multi-core processors

    NARCIS (Netherlands)

    Varbanescu, A.L.

    2010-01-01

    Multi-core processors are considered now the only feasible alternative to the large single-core processors which have become limited by technological aspects such as power consumption and heat dissipation. However, due to their inherent parallel structure and their diversity, multi-cores are

  13. The Relationship between Radio Luminosity and Core-Dominance ...

    Indian Academy of Sciences (India)

    Abstract. In this work, we investigate the correlation between the lumi- nosity and the core-dominance parameter for a sample of X-ray selected. BL Lacertae objects (XBLs), and found that the extended luminosity is strongly anti-correlated with the core-dominance parameter while the core (or the total) luminosity is not ...

  14. Deriving criteria by which to determine core curriculum content: A ...

    African Journals Online (AJOL)

    Background. During curriculum revision, an important task is identifying a core curriculum. Deciding what criteria to use to determine core content is crucial and impacts on graduate outcomes and patient care. Objective. To identify criteria to apply in order to determine core content. Methods. A high engagement process ...

  15. Does the Center Hold? Reflections on a Sociological Core

    Science.gov (United States)

    Ballantine, Jeanne; Greenwood, Nancy; Howard, Jay R.; Kain, Edward L.; Pike, Diane; Schwartz, Michael; Smith, R. Tyson; Zipp, John F.

    2016-01-01

    Is there a distinct disciplinary core (or foundation of agreed on knowledge) in sociology? Should we define a core in our broad field to build consensus? If so, what should it look like? We address these questions by presenting three viewpoints that lean for and against identifying a core for department curricula, students, and the public face of…

  16. Common Core Implementation Decisions Made by Principals in Elementary Schools

    Science.gov (United States)

    Norman, Alexis Cienfuegos

    2016-01-01

    The purpose of this study was to understand the decisions elementary principals have made during the Common Core State Standards reform. Specifically, (a) what decisions principals have made to support Common Core implementation, (b) what strategies elementary principals have employed to communicate with stakeholders about Common Core State…

  17. Market strategies and core capabilities in the building industry

    NARCIS (Netherlands)

    de Haan, Job; Voordijk, Johannes T.; Joosten, Geert-Jan

    2002-01-01

    The objective of this study is to show that the core competence approach has validity when applied to construction. The focus is on the analysis ofthe fit between market strategies of firms in the building industry and their core capabilities. Certain strategies require specific core capabilities

  18. Exploring the Role of Agriculture Teachers in Core Academic Integration

    Science.gov (United States)

    McKim, Aaron J.; Sorenson, Tyson J.; Velez, Jonathan J.

    2016-01-01

    Core academic skills are essential for success in our society. However, an abundance of research has identified a large proportion of secondary school students are under performing in core academic areas such as literacy and math. Researchers have suggested integrating core academic content throughout all secondary coursework as a potential…

  19. A rapid and convergent synthesis of the integrastatin core

    KAUST Repository

    Tadross, Pamela M.

    2011-01-01

    The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(ii)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds. © 2011 The Royal Society of Chemistry.

  20. Computer-Aided Test Flow in Core-Based Design

    NARCIS (Netherlands)

    Zivkovic, V.; Tangelder, R.J.W.T.; Kerkhoff, Hans G.

    2000-01-01

    This paper copes with the efficient test-pattern generation in a core-based design. A consistent Computer-Aided Test (CAT) flow is proposed based on the required core-test strategy. It generates a test-pattern set for the embedded cores with high fault coverage and low DfT area overhead. The CAT