WorldWideScience

Sample records for von deilephila euphorbiae

  1. Euphorbia heterophylla L.

    African Journals Online (AJOL)

    SARAH

    30 sept. 2015 ... de lait (Euphorbia heterophylla L.) ou aux feuilles de patate douce (Ipomoea batatas (L.) Lam) sur la croissance des lapins ... contrôlée des feuilles peut induire une baisse de la production de tubercules d'environ 32%. Méthodologie et ..... d'augmenter la valeur énergétique du régime et la productivité des ...

  2. Eine neue Euphorbia aus Malesien

    NARCIS (Netherlands)

    Pax, F.; Hoffmann, Käthe

    1938-01-01

    Euphorbia Backeri PAX et K. HOFFM. n. sp. — Gaules 40—150 cm alti, plerumque 60 cm superantes, basi ad 1 cm diametientes, solitarii, a basi erecti, apice saepe nutantes, basi saepe lignescentes, superne ramosi, ramis oblique erectis, simplicibus vel ramosis. Partes juveniles ± dense pilis albis, ad

  3. Global medicinal uses of Euphorbia L. (Euphorbiaceae)

    DEFF Research Database (Denmark)

    Ernst, Madeleine; Grace, Olwen M; Saslis Lagoudakis, Haris

    2015-01-01

    in Australia, topical application of latex of Euphorbia peplus L. is used as a home treatment for skin cancer and actinic keratosis. Its use in Australian folk medicine has inspired the release of the drug Picato ® (ingenol mebutate), and further fostered interest in natural products and medicinal uses...... of Euphorbia in recent years. Aim of the study: To provide an indicative overview of medicinal uses of the genus Euphorbia driven by the recent interest in biologically active natural products from Euphorbia in drug discovery. We assess documented medicinal knowledge and value of the genus Euphorbia...... and the taxonomic distribution of this value. Materials and Methods: We undertook an extensive survey of over 260 multidisciplinary publications on the online repository JSTOR using the search term “Euphorbia medicinal”. Results: Medicinal uses were identified for > 5% of the species in the genus, including...

  4. Global medicinal uses of Euphorbia L. (Euphorbiaceae).

    Science.gov (United States)

    Ernst, Madeleine; Grace, Olwen M; Saslis-Lagoudakis, C Haris; Nilsson, Niclas; Simonsen, Henrik Toft; Rønsted, Nina

    2015-12-24

    The genus Euphorbia (spurges, Euphorbiaceae) is the third largest genus of flowering plants, with almost 2000 species. Its exceptional diversity of growth forms and near-cosmopolitan distribution have attracted human interest since ancient times. For instance in Australia, topical application of latex of Euphorbia peplus L. is used as a home treatment for skin cancer and actinic keratosis. Its use in Australian folk medicine has inspired the release of the drug Picato® (ingenol mebutate), and further fostered interest in natural products and medicinal uses of Euphorbia in recent years. To provide an indicative overview of medicinal uses of the genus Euphorbia driven by the recent interest in biologically active natural products from Euphorbia in drug discovery. We assess documented medicinal knowledge and value of the genus Euphorbia and the taxonomic distribution of this value. We undertook an extensive survey of over 260 multidisciplinary publications on the online repository JSTOR using the search term "Euphorbia medicinal". Medicinal uses were identified for >5% of the species in the genus, including descriptions of treatments for a variety of diseases. The most-cited medicinal uses around the world were treatments for digestive system disorders, skin ailments and, especially in the Southern hemisphere, infections. Consensus ratios indicated that the most-valued medicinal uses of Euphorbia species are in the treatment of digestive and respiratory complaints, inflammation and injuries, especially by members of Euphorbia subg. Chamaesyce. The present study gives a first indicative overview of Euphorbia species used for health and wellbeing around the world. The exceptional diversity of the genus Euphorbia is not only represented by its growth forms but also by its diverse medicinal uses. Our results highlight the importance of research into medicinal uses of Euphorbia species and their importance as a source of natural products. Furthermore the medicinally

  5. Will tree euphorbias (Euphorbia tetragona and Euphorbia triangularis) survive under the impact of black rhinoceros (Bicornis diceros minor) browsing in the Great Fish River Reserve, South Africa?

    NARCIS (Netherlands)

    Heilmann, L.C.; Jong, de K.; Lent, P.C.; Boer, de W.F.

    2006-01-01

    The impact of black rhinoceros (Bicornis diceros minor) on the tree euphorbias Euphorbia tetragona and Euphorbia triangularis was studied in the Great Fish River Reserve, South Africa. Black rhinoceros pushed over about 5¿7% of the trees in a 2-month period. There was a preference of rhinos for

  6. Chromatographic study of Euphorbia cyparissias

    Directory of Open Access Journals (Sweden)

    Cristina, T. Romeo,

    2009-12-01

    Full Text Available The ectoparasitic population control is very difficult and includes numerous chemical substances and therapeutic techniques. Although efficient at first, the repeated use of acaricidal substances leads to the appearance of resistance. The more and more reduced efficacy of the therapeutic arsenal puts serious problems for the practitionersand increases the need of newer substances on the market. Besides this appears the problem of residues in eggs and meat, which is a serious impediment. Because of this the use of plant extracts is an attractive and promising research path. The investigations tied to the parasitic biocontrol have diversified with the study of the numerous control sources (fungi, plant extracts, volatile oils etc..In this context, the plant extracts can become an alternative source for the acaricidal control knowing that they constitute a rich source of efficient bioactive compounds. Unfortunately although at hand until today, not very much data is known about what determines theacaricidal activity of some plant extracts against the argaside ticks.The present work describes an in vitro CG-MS study for identification of Euphorbia cyparissias’ chemical composition.

  7. RAPD-PCR analysis of some species of Euphorbia grown in ...

    African Journals Online (AJOL)

    This study attempts to identify species of Euphorbia (Euphorbia peplus, Euphorbia helioscopia, Euphorbia granulata and Euphorbia hirta) grown in University of Baghdad Campus in Jadiriyah and determine the genetic polymorphism among them by using DNA markers generated by polymerase chain reaction (PCR).

  8. Diterpenoids and triterpenoids from Euphorbia retusa.

    Science.gov (United States)

    Haba, Hamada; Lavaud, Catherine; Magid, Abdulmagid Alabdul; Benkhaled, Mohammed

    2009-07-01

    Six new ent-abietane lactones (1-6), three new esterified tetracyclic triterpenes (7-9), and seven known diterpenoids and triterpenoids were isolated from the roots of Euphorbia retusa. Their structures were elucidated by means of spectroscopic studies including 1D and 2D NMR, mass spectrometry, chemical transformation, and comparison with literature data.

  9. Antibacterial activity of Euphorbia hirta against Streptococcus ...

    African Journals Online (AJOL)

    This investigation was conducted to determine the in-vitro effect of aqueous, ethanol and methanol crude extracts of Euphorbia hirta at concentrations ranging from 10mg/ml – 100mg/ml against three pathogenic bacteria (Streptococcus pneumoniae, Klebsiella pneumoniae and Proteus vulgaris) using cup plate method.

  10. Poinsettia (Euphorbia pulcherrima Willd. ex Klotzsch).

    Science.gov (United States)

    Islam, M Ashraful; Thorstensen, Tage; Clarke, Jihong Liu

    2015-01-01

    Genetic engineering is an important tool for introducing desired genes into poinsettia (Euphorbia pulcherrima Willd. ex Klotzsch). We describe in this chapter an Agrobacterium tumefaciens-mediated transformation protocol for poinsettia. A detailed description of genetic transformation, antibiotic selection, subsequent regeneration via somatic embryogenesis, and rooting as well as molecular and morphological analyses is included. The methodology described here could facilitate the future engineering of poinsettia for research purpose as well as commercial production of poinsettia plants with improved resistance or novel traits.

  11. Acute Toxicity of Crude Euphorbia tirucalli Latex Extracts to ...

    African Journals Online (AJOL)

    Acute toxicity of crude Euphorbia tirucalli latex extracts to Oreochromis niloticus juveniles was investigated in the College of Agriculture, Lafia. A four day static acute toxicity test was performed to determine the LC50 value of crude Euphorbia tirucalli latex extract for the fresh water fish, Oreochromis niloticus. Various ...

  12. Phytochemical relationship of Euphorbia helioscopia and Euphorbia pulcherrima with Lactuca sativa.

    Science.gov (United States)

    Rehman, Hafiza Ayesha; Yousaf, Zubaida; Rashid, Madiha; Younas, Afifa; Arif, Ayesha; Afzal, Ismah; Akram, Waheed

    2014-01-01

    Allelopathy is an important phenomenon that modifies the ecosystem. A plant can enhance or reduce the growth of other plant due to the presence of a number of allelochemicals in its different parts. Euphorbia helioscopia and Euphorbia pulcherrima are medicinal plant species. Both these species are collected from wild resources for various purposes. To reduce the pressure on wild population, it is important to bring them into cultivation. Therefore, the allelopathic effects of E. helioscopia and E. pulcherrima on the growth of lettuce seeds were studied. Three different concentrations (2%, 4% and 6%) of five different solvents (methanol, acetone, ethyl acetate, n-hexane and distilled water) were used to estimate the allelopathic potential of the above-mentioned Euphorbia species. Results indicated a non-significant growth inhibitory effect of both plants on lettuce seeds. Different extracts reduced the growth of test plant to some extent but this inhibition was not significant. From the observed results, it was concluded that the studied Euphorbia species, being medicinally important crops, can be introduced as intercrop with other cash crops.

  13. Evolutionary prediction of medicinal properties in the genus Euphorbia L

    DEFF Research Database (Denmark)

    Ernst, Madeleine; Saslis Lagoudakis, Haris; Grace, Olwen M.

    2016-01-01

    of medicinal plant use classification. In the cosmopolitan and pharmaceutically highly relevant genus Euphorbia L., identifying plant uses modulating the inflammatory response highlighted a greater phylogenetic diversity and number of potentially promising species than standardised categories. Our...

  14. Euphorbia esula: Achieving Management Objectives: Analysis of 2000 Data

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In spring 2000, we continued to assess the ecological impacts of the invasive non-native species Euphorbia esula (leafy spurge) on rangeland and natural areas in the...

  15. Phytotoxin produced by Bipolaris euphorbiae in-vitro is effective against the weed Euphorbia heterophylla

    Directory of Open Access Journals (Sweden)

    Barbosa Aneli M.

    2002-01-01

    Full Text Available Four virulent strain isolates of the fungus, Bipolaris euphorbiae (previously identified as a Helminthosporium sp., isolated from host plants in four states within Brazil were screened for the production of phytotoxins that promoted wilting and defoliation of the Brazilian weed, Euphorbia heterophylla, commonly found growing among soyabean crops. Only one isolate, B. euphorbiae Strain I (EUPH petropar from Mato Grosso state, produced phytotoxin in-vitro when grown in stationary culture for 7 d at 28 ° C on minimum salts medium supplemented with 1.5 % glucose as the sole carbon source. Phytotoxin was also produced when the fungal strain was grown on fructose, galactose, mannose, xylose and sucrose. The addition of nitrogen source (yeast extract, peptone or malt extract to the culture medium did not influence phytotoxin production. The phytotoxin produced by Strain I was most active at pH 6.0, stable between pH 3-9, and was highly thermostable, remaining fully active when heated at 90 ° C for 1 h.

  16. Evolutionary bursts in Euphorbia (Euphorbiaceae) are linked with photosynthetic pathway.

    Science.gov (United States)

    Horn, James W; Xi, Zhenxiang; Riina, Ricarda; Peirson, Jess A; Yang, Ya; Dorsey, Brian L; Berry, Paul E; Davis, Charles C; Wurdack, Kenneth J

    2014-12-01

    The mid-Cenozoic decline of atmospheric CO2 levels that promoted global climate change was critical to shaping contemporary arid ecosystems. Within angiosperms, two CO2 -concentrating mechanisms (CCMs)-crassulacean acid metabolism (CAM) and C4 -evolved from the C3 photosynthetic pathway, enabling more efficient whole-plant function in such environments. Many angiosperm clades with CCMs are thought to have diversified rapidly due to Miocene aridification, but links between this climate change, CCM evolution, and increased net diversification rates (r) remain to be further understood. Euphorbia (∼2000 species) includes a diversity of CAM-using stem succulents, plus a single species-rich C4 subclade. We used ancestral state reconstructions with a dated molecular phylogeny to reveal that CCMs independently evolved 17-22 times in Euphorbia, principally from the Miocene onwards. Analyses assessing among-lineage variation in r identified eight Euphorbia subclades with significantly increased r, six of which have a close temporal relationship with a lineage-corresponding CCM origin. Our trait-dependent diversification analysis indicated that r of Euphorbia CCM lineages is approximately threefold greater than C3 lineages. Overall, these results suggest that CCM evolution in Euphorbia was likely an adaptive strategy that enabled the occupation of increased arid niche space accompanying Miocene expansion of arid ecosystems. These opportunities evidently facilitated recent, replicated bursts of diversification in Euphorbia. © 2014 The Author(s). Evolution © 2014 The Society for the Study of Evolution.

  17. Anti-inflammatory activity of Euphorbia aegyptiaca extract in rats

    Science.gov (United States)

    Abo-dola, Marium A.; Lutfi, Mohamed F.

    2016-01-01

    Background There were no studies on the anti-inflammatory activity of Euphorbia aegyptiaca, though it is commonly used by Sudanese herbalists in the treatment of rheumatoid arthritis. Objectives To determine phytochemical constituents of Euphorbia aegyptiaca To investigate the anti-inflammatory activity of Euphorbia aegyptiaca in rats. Methodology Plant material was extracted by ethanol and phytochemical screening was done according to standard methods. The thickness of Albino rats’ paws were measured before injection of 0.1 ml of 1% formalin in the sub planter region and then, 1, 2, 3, 4 and 24 hours after oral dose of ethanolic extract of Euphorbia aegyptiaca at a rate of 400mg/kg, 800mg/kg, indomethacin (5mg/kg) and normal saline (5ml/kg). Edema inhibition percentage (EI%) and mean paw thickness (MPT) were measured in the different groups and compared using appropriate statistical methods. Results The phytochemical screening revealed the presence of saponins, cumarins, flavonoids, tannins, sterols, triterpenes, and absence of alkaloids, anthraquinones glycosides and cyanogenic glycosides. The mean of EI% of rats treated with indomethacin at a dose of 5 mg/kg over different time intervals (64.0%) was significantly lower compared to those treated with Euphorbia aegyptiaca at a dose of 800 mg/kg (75.0%, P< 0.001), but higher compared to rats treated at higher dose of 400 mg/kg (57.4%, P< 0.001). In contrast, MPT of rats treated with indomethacin at a dose of 5 mg/kg (6.5±1.1 mm) was significantly higher compared to those treated with Euphorbia aegyptiaca at a dose of 800 mg/kg (6.1±.7 mm, P< 0.001) as well as 400 mg/kg (5.9±.5, P< 0.001). Conclusion Euphorbia aegyptiaca ethanolic extract has a sustained dose-dependent anti-inflammatory activity. PMID:27004059

  18. In Vitro Anticancer Activity of Ethanolic Extract of Euphorbia hirta (L ...

    African Journals Online (AJOL)

    In the present study, In vitro anticancer effects of Euphorbia hirta were investigated. The objectives of this study are to find the presence of secondary metabolites by preliminary phytochemical investigation and FTIR analysis in the Euphorbia hirta. Ethanolic leaf extract of Euphorbia hirta was tested for its cytotoxicity against ...

  19. Euphorbia factor L8: a diterpenoid from the seeds of Euphorbia lathyris

    Directory of Open Access Journals (Sweden)

    Zhi-hua Mao

    2008-01-01

    Full Text Available The title compound [systematic name: (2S*,3S*,4R*,5R*,9S*,11S*,15R*-5,15-diacetoxy-3-nicotinoyloxy-14-oxolathyra-6(17,12(E-diene], C30H37NO7, was isolated from the seeds of Euphorbia lathyris. The tricyclic diterpenoid molecule contains an 11-membered ring, a five-membered ring exhibiting an envelope conformation and a three-membered ring. The 11-membered ring is cis-fused with the three-membered ring and trans-fused with the five-membered ring.

  20. Técnica de cruzamentos controlados em Euphorbia heterophylla L. Crossing technique in Euphorbia heterophylla L.

    Directory of Open Access Journals (Sweden)

    LEANDRO VARGAS

    1999-01-01

    Full Text Available O leiteiro, Euphorbia heterophylla L., é uma planta daninha comum no Sul, no Sudeste e no Centro-Oeste do Brasil. Seu controle químico é realizado principalmente com herbicidas que agem inibindo a enzima acetolactato sintase. Contudo, nos últimos anos, vêm sendo observados genótipos resistentes em diversas lavouras da região Sul. Até o momento, não se realizaram estudos sobre as características genéticas de tal resistência. Este trabalho teve como objetivo descrever uma técnica de cruzamento controlado em Euphorbia heterophylla L., para viabilizar futuros estudos genéticos. Efetuaram-se hibridações controladas em diversas fases do desenvolvimento do botão floral das plantas. As polinizações e emasculações realizadas no estádio 1(quando as flores femininas apresentam estiletes separados, eretos e com coloração avermelhada, e ovário incluso no ciátio produzem grande número de ciátios com uma ou duas sementes e raras com três. As realizadas no estádio 2 (momento em que os estiletes estão separados e pouco reflexos sobre o ciátio com alteração da coloração avermelhada para branca, com a extremidade bifurcada, e ovário ainda incluso no ciátio ou acima deste, garantiram o sucesso dos cruzamentos com boa produção de sementes.Euphorbia heterophylla L. is a common weed in the South, Southeast, and Central West portions of Brazil. Chemical control is mainly done with herbicides that inhibit the enzyme Acetolactate synthase. However, resistant individuals have being observed in several farms of the South Region. There is no information about the genetic control of such resistance. The present work was aimed to study the hybridization technique in Euphorbia heterophylla L. It was studied the anatomy and the organogenesis of different individuals. Controlled emasculations and pollinations carried out in the stage 1(when the flowers present separate styles, erect and red, and ovary inside of the cyathium produce great

  1. Euphorbia plant latex is inhabited by diverse microbial communities.

    Science.gov (United States)

    Gunawardana, Manjula; Hyde, Embriette R; Lahmeyer, Sean; Dorsey, Brian L; La Val, Taylor P; Mullen, Madeline; Yoo, Jennifer; Knight, Rob; Baum, Marc M

    2015-12-01

    The antimicrobial properties and toxicity of Euphorbia plant latex should make it a hostile environment to microbes. However, when specimens from Euphorbia spp. were propagated in tissue culture, microbial growth was observed routinely, raising the question whether the latex of this diverse plant genus can be a niche for polymicrobial communities. Latex from a phylogenetically diverse set of Euphorbia species was collected and genomic microbial DNA extracted. Deep sequencing of bar-coded amplicons from taxonomically informative gene fragments was used to measure bacterial and fungal species richness, evenness, and composition. Euphorbia latex was found to contain unexpectedly complex bacterial (mean: 44.0 species per sample; 9 plants analyzed) and fungal (mean: 20.9 species per sample; 22 plants analyzed) communities using culture-independent methods. Many of the identified taxa are known plant endophytes, but have not been previously found in latex. Our results suggest that Euphorbia plant latex, a putatively hostile antimicrobial environment, unexpectedly supports diverse bacterial and fungal communities. The ecological roles of these microorganisms and potential interactions with their host plants are unknown and warrant further research. © 2015 Botanical Society of America.

  2. Keratouveitis from Euphorbia cyparissias exposure is a temporal phenomenon

    Directory of Open Access Journals (Sweden)

    Fleischman D

    2012-06-01

    Full Text Available David Fleischman, Jay J Meyer, W Craig FowlerDepartment of Ophthalmology, University of North Carolina Hospitals, Chapel Hill, NC, USAAbstract: We present the case of an 82-year-old woman with severe keratouveitis secondary to exposure to the plant Euphorbia cyparissias during the month of August. Despite copious irrigation of both eyes, she developed a case of Euphorbia keratouveitis that was typical in its course. Exposure to plant sap from this species should be treated much like an alkaline chemical injury as the pH of the ocular surface may be elevated. E. cyparissias should be carefully handled as it may result in keratouveitis, especially in early autumn.Keywords: Euphorbia cyparissias, sap, keratitis, uveitis

  3. Biosynthesis of macrocyclic diterpenoids in Euphorbia lathyris L

    DEFF Research Database (Denmark)

    Luo, Dan

    documents the investigation of the biosynthetic pathways of macrocyclic diterpenoids known as Euphorbia factors in Euphorbia lathyris L. (caper spurge). These macrocyclic diterpenoids are the current industrial source of ingenol mebutate, which is approved for the treatment of actinic keratosis......, a precancerous skin condition. Metabolite profiling of various tissues of E. lathyris L. revealed that the mature seeds constituted a highly specialized tissue for the biosynthesis of lathyrane and ingenane diterpenoids. RNA–seq and transcriptome analysis of E. lathyris L. mature seeds followed by functional...

  4. Triterpenoid biosynthesis in Euphorbia lathyris latex

    Energy Technology Data Exchange (ETDEWEB)

    Hawkins, D.R.

    1987-11-01

    The structures of triterpenols, not previously been known, from Euphorbia lathyris latex are reported. A method for quantifying very small amounts of these compounds was developed. Concerning the biochemistry of the latex, no exogenous cofactors were required for the biosynthesis and the addition of compounds such as NADPAH and ATP do not stimulate the biosynthesis. The addition of DTE or a similar anti-oxidant was found to help reduce the oxidation of the latex, thus increasing the length of time that the latex remains active. The requirement of a divalent cation and the preference for Mn in the pellet was observed. The effect of several inhibitors on the biosynthesis of the triterpenoids was examined. Mevinolin was found to inhibit the biosynthesis of the triterpenoids from acetate, but not mevalonate. A dixon plot of the inhibition of acetate incorporation showed an I/sub 50/ concentration of 3.2 ..mu..M. Fenpropimorph was found to have little or no effect on the biosynthesis. Tridemorph was found to inhibit the biosynthesis of all of the triterpenoids with an I/sub 50/ of 4 ..mu..M. It was also observed that the cyclopropyl containing triterpenols, cycloartenol and 24-methylenecycloartenol were inhibited much more strongly than those containing an 8-9 double bond, lanosterol and 24-methylenelanosterol. The evidence indicates, but does not definetely prove, that lanosterol and 24-methylenelanosterol are not made from cycloartenol and 24-methylenecycloartenol via a ring-opening enzyme such as cycloeucalenol-obtusifoliol isomerase. The possibilty that cycloartenol is made via lanosterol was investigated by synthesizing 4-R-4-/sup 3/H-mevalonic acid and incubating latex with a mixture of this and /sup 14/C-mevalonic acid. From the /sup 3/H//sup 14/C ratio it was shown that cycloartenol and 24-methylenecycloartenol are not made via an intermediate containing as 8-9 double bond. 88 refs., 15 figs., 30 tabs.

  5. On the origin of Euphorbia subg. Esula in Europe (Euphorbiaceae)

    NARCIS (Netherlands)

    Kuzmanov, B.

    1964-01-01

    A study of the taxonomy and chorology of the Bulgarian species of Euphorbia has led me to consider their phytogeography; this entailed a closer view on the main features of florogenesis and distribution of subg. Esula in Europe. There are two problems concerned, viz. the origin of the two sections

  6. Catalytic properties of lipase from Ficus trichopoda and Euphorbia ...

    African Journals Online (AJOL)

    ... from Ficus trichopoda latex was able to attack specific oil to generate free fatty acids or ester as the major product. This understanding may help in devising efficient methods to produce valuable modified oils. Keywords: Latex; Lipase activity; esterification reaction; typo-selectivity; Ficus trichopoda; Euphorbia unispina ...

  7. Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds

    NARCIS (Netherlands)

    Duarte, Noelia; Kayser, Oliver; Abreu, Pedro; Ferreira, Maria-Jose U.

    In the search for biologically active compounds from Euphorbia lagascae Spreng, an herbaceous plant native to southeast of Iberic Peninsula, a stilbene, two coumarins and two 1-2-deoxyphorbol diterpene esters were isolated by chromatographic methods, from the methanol extracts of its defatted seeds.

  8. Seed germination and growth of Eleucine indica and Euphorbia ...

    African Journals Online (AJOL)

    Three experiments were conducted in a glasshouse and a laboratory to provide information on the effect of glyphosate (N-(phosphonomethyl) glycine) on, seed germination, seedling emergence and growth of goosegrass (Eleucine indica (L.) Gaertn) and wild poinsettia (Euphorbia heterophylla Linn), Glyphosate sprayed ...

  9. Inhibition effect of flavonoid extract of Euphorbia guyoniana on the ...

    African Journals Online (AJOL)

    The influence of flavonoids extracts of three parts of Euphorbia Guyoniana towards the corrosion of type API 5L X52 steel in 15% H2SO4 has been evaluated by weight loss method and polarization technique. The results showed that extracts are a good inhibitors for API 5L X52 steel in this medium. The corrosion inhibition ...

  10. Antiproliferative activity of extracts of Euphorbia tirucalli L ...

    African Journals Online (AJOL)

    Espírito Santo, 5Instituto Federal de Educação, Ciência e Tecnologia do Espírito Santo, Campus Vila Velha, Avenida Ministro. Salgado Filho ..... Brasil, 2005. 9. Aquino CL, Barbosa GM, Varricchio MCBA, Veiga VF,. Kuster RM, Zancan P, Sola-Penna M, Holandino C. High dilutions of Euphorbia tirucalli L.(aveloz) modify the.

  11. Screening of endophytic fungi that promote the growth of Euphorbia ...

    African Journals Online (AJOL)

    This study explored a strategy to use endophytic fungi for promoting the growth of the medicinal plant, Euphorbia pekinensis. The growth of E. pekinensis was examined in pot culture following inoculation of. E. pekinensis with endophytic fungal strains (Fusarium spp.) from E. pekinensis (E4 and E5) and those not from E.

  12. Euphorbias of South Africa: Two New Phorbol Esters from ...

    African Journals Online (AJOL)

    Standard spectroscopic techniques were used to elucidate the structures of all four compounds. The interaction of 1–4 with opioid receptors was explored in an attempt to explain the unexplained stupor occasionally observed in herbivores browsing on E. bothae. Keywords: Euphorbia bothae, Euphorbiaceae, Phorbol Ester, ...

  13. Updates on the genus Euphorbia (Euphorbiaceae) in Santa Catarina, Brazil

    DEFF Research Database (Denmark)

    Hassemer, Gustavo; Marques da Silva, Otávio Luis; Funez, Luís Adriano

    2017-01-01

    This contribution presents updates to the knowledge of the species of Euphorbia that occur in Santa Catarina state, southern Brazil. More specifically, we here typify the names E. cyathophora, E. hirtella, E. paranensis and E. stenophylla, and present the first records of E. cyathophora, E...

  14. Antiproliferative activity of extracts of Euphorbia tirucalli L ...

    African Journals Online (AJOL)

    Purpose: To investigate Euphorbia tirucalli extract for probable geographic variations in its antiproliferative activity. Methods: The aerial parts of E. tirucalli were collected in the Brazilian states of Mato Grosso, Rio de Janeiro, Pará, Minas Gerais and Santa Catarina. The 70 % ethanol extract was obtained according to the ...

  15. Protective effect of Euphorbia neriifolia saponin fraction on CCl 4 ...

    African Journals Online (AJOL)

    Jane

    2010-10-18

    Oct 18, 2010 ... The present investigation aims at assessing the hepatoprotective effect of saponin fraction isolated from the leaf of Euphorbia neriifolia on CCl4-induced hepatotoxicity on rat. CCl4 (1.5 mg/kg, i.p) is a potent hepatotoxic agent, which induces peroxidative degeneration of membrane lipids causing.

  16. The Anti-Sickling Properties of Ethanol Extracts of Euphorbia ...

    African Journals Online (AJOL)

    The ethanol extracts of Euphorbia heterophylla and Moringa oleifera showed potential anti-sickling activity. The sickling inhibition and reversal activities of the extracts were significant (P<0.05) compared to their negative controls without the extracts at all. Moringa oleifera however showed greater anti-sickling activity of 93% ...

  17. Antimicrobial efficacy and tissue reaction of Euphorbia hirta ...

    African Journals Online (AJOL)

    Antimicrobial efficacy and tissue reaction of crude ethanolic extract of Euphorbia hirta was investigated in canine infected incised wounds. The gross appearance and histopathological reactions of the lesions were evaluated at 72 h after treatment. The results showed that crude ethanolic extract of E. hirta neither promoted ...

  18. Protective effect of Euphorbia neriifolia saponin fraction on CCl 4 ...

    African Journals Online (AJOL)

    The present investigation aims at assessing the hepatoprotective effect of saponin fraction isolated from the leaf of Euphorbia neriifolia on CCl4-induced hepatotoxicity on rat. CCl4 (1.5 mg/kg, i.p) is a potent hepatotoxic agent, which induces peroxidative degeneration of membrane lipids causing hypoperfusion of the ...

  19. Terpenoid compounds from the latex of Euphorbia drupifera ...

    African Journals Online (AJOL)

    This study aimed at the isolation and characterization of terpenoid compounds from the latex of Euphorbia drupifera. Methylated spirit extract of the latex was suspended in aqueous methanol and partitioned with petroleum spirit. The aqueous methanol residue was washed with ether. The ethereal fraction was subjected to ...

  20. Effect of Euphorbia hirta and Thymus vulgaris powders on ...

    African Journals Online (AJOL)

    The ban placed on the long term use of commercial antibiotics at subtherapeutic levels for diseases control and growth promotion in livestock production necessitated a worldwide search for available, cost effective and efficacious alternatives. Accordingly, the effects of Euphorbia hirta (EH) and Thymus vulgaris (TV) ...

  1. Radioprotective and In-Vitro Cytotoxic Sapogenin from Euphorbia ...

    African Journals Online (AJOL)

    Purpose: Euphorbia neriifolia Linn. (Euphorbiaceae) plant is traditionally used in the treatment of abdominal troubles, bronchitis, tumours, leucoderma, piles, inflammation, and enlargement of spleen. The objective of this study was to evaluate the antioxidant and anticancer activities of a sapogenin isolate of this plant.

  2. Sporoderm morphogenesis in Euphorbia obesa and Croton gratissimus

    Directory of Open Access Journals (Sweden)

    M. L. Frean

    1983-12-01

    Full Text Available Pollen grains of the Euphorbiaceae show a number of pollen types which can be clearly distinguished. Generally different genera are characterized by a specific pollen type.  Euphorbia obesa Hook. f. and Croton gratissimus Burch, subsp.  subgratissimus (Prain Burtt Davy, represent two genera within the Crotonoideae with different morphology, each type characteristic for the respective genus. Taxonomically, the genus Euphorbia with apetalous flowers consisting of a naked pistil surrounded by several staminate flowers within a cyathium, is considered more advanced than the genus  Croton. In  Croton the inflorescence is a raceme with unisexual flowers. The floral whorls of the male show numerous anthers and both calyx and a showy corolla are present. Both genera are insect pollinated. In both  Euphorbia obesa and  Croton gratissimus the pollen wall in section shows columellae, a structure characteristic of angiosperms. However the present ontogenetic studies show that the formation of the columellae differs entirely in the two pollen types. The final stratification of the wall as well as the morphology of the grains differ and evaluation of the exine structure indicates that phylogenetically Croton pollen shows more advanced characters than  Euphorbia — contradicting the floral phylogeny. This study conducted at light and electron microscope level compares the two pollen types morphologically and ontogenetically, concentrating mainly on the formation of the exine which is tectate-perforate in the prolate tricolpate grain of Euphorbia obesa and semi-tectate in the anaperturate, spheroidal grain of Croton gratissimus. The aim of the study was to evaluate the significance of pollen characters in taxonomic and phylogenetic relationships within the Euphorbiaceae. The differing pollen morphology which is related to the taxonomic grouping of tribes within the subfamily (Crotonoideae emphasizes diversity, which may result from physiological

  3. Sporoderm morphogenesis in Euphorbia obesa and Croton gratissimus

    Directory of Open Access Journals (Sweden)

    M. L. Frean

    1983-11-01

    Full Text Available Pollen grains of the Euphorbiaceae show a number of pollen types which can be clearly distinguished. Generally different genera are characterized by a specific pollen type.  Euphorbia obesa Hook. f. and Croton gratissimus Burch, subsp.  subgratissimus (Prain Burtt Davy, represent two genera within the Crotonoideae with different morphology, each type characteristic for the respective genus. Taxonomically, the genus Euphorbia with apetalous flowers consisting of a naked pistil surrounded by several staminate flowers within a cyathium, is considered more advanced than the genus  Croton. In  Croton the inflorescence is a raceme with unisexual flowers. The floral whorls of the male show numerous anthers and both calyx and a showy corolla are present. Both genera are insect pollinated. In both  Euphorbia obesa and  Croton gratissimus the pollen wall in section shows columellae, a structure characteristic of angiosperms. However the present ontogenetic studies show that the formation of the columellae differs entirely in the two pollen types. The final stratification of the wall as well as the morphology of the grains differ and evaluation of the exine structure indicates that phylogenetically Croton pollen shows more advanced characters than  Euphorbia — contradicting the floral phylogeny. This study conducted at light and electron microscope level compares the two pollen types morphologically and ontogenetically, concentrating mainly on the formation of the exine which is tectate-perforate in the prolate tricolpate grain of Euphorbia obesa and semi-tectate in the anaperturate, spheroidal grain of Croton gratissimus. The aim of the study was to evaluate the significance of pollen characters in taxonomic and phylogenetic relationships within the Euphorbiaceae. The differing pollen morphology which is related to the taxonomic grouping of tribes within the subfamily (Crotonoideae emphasizes diversity, which may result from physiological

  4. Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.

    Science.gov (United States)

    Gao, Jie; Aisa, Haji A

    2017-06-23

    Ten new terpenoids, including five diterpenoids (1-5), three nortriterpenoids (6-8), and two triterpenoids (9, 10), and 15 known terpenoids (11-25) were isolated from an acetone extract of Euphorbia soongarica. Sooneuphoramine (1) is the first example of a euphoractine B-type diterpenoid alkaloid, while sooneuphanones A-C (6-8) are rare nortriterpenoids from the Euphorbia genus. The isolated terpenoids were tested for their cytotoxicity and multidrug resistance (MDR) reversal activity, 10 of which showed moderate cytotoxicity against the KB and KBv200 cell lines, while 11 compounds exhibited P-gp modulating potential. The triterpenoid sooneuphanone D (9) possessed a remarkable MDR reversal activity much higher than the positive control, verapamil.

  5. Assessment of Immunomodulatory Activity of Euphorbia hirta L.

    Science.gov (United States)

    Ramesh, K Vijaya; Padmavathi, K

    2010-09-01

    Immune system is the major target for development of treatment strategies to improve the management of infections. Many species of Indian medicinal plants have been reported to possess active principles with immunomodulating properties. Euphorbia hirta, a pantropic herb has been reported to be pharmacologically active. This study reports one another not widely reported property of the plant, immunomodulatory activity, which has been proved using simple techniques like the macrophage activity testing, carbon clearance test and mast cell de-granulation assay.

  6. Assessment of Immunomodulatory Activity of Euphorbia hirta L.

    OpenAIRE

    Ramesh, K. Vijaya; K.padmavathi

    2010-01-01

    Immune system is the major target for development of treatment strategies to improve the management of infections. Many species of Indian medicinal plants have been reported to possess active principles with immunomodulating properties. Euphorbia hirta, a pantropic herb has been reported to be pharmacologically active. This study reports one another not widely reported property of the plant, immunomodulatory activity, which has been proved using simple techniques like the macrophage activity ...

  7. Euphorbia gummifera. A. gregaria and a new species from Damaraland

    Directory of Open Access Journals (Sweden)

    L. C. Leach

    1975-11-01

    Full Text Available The identity of  Euphorbia gummifera Boiss. and  E. gregaria Marl, is discussed and a new species, E. damarana Leach, is described. A key to the species including  E. carunculifera Leach from southern Angola and a map showing their distribution are provided. The possible significance of these species in the phylogeny of the genus is also discussed.

  8. Euphorbia gummifera. A. gregaria and a new species from Damaraland

    Directory of Open Access Journals (Sweden)

    L. C. Leach

    1975-12-01

    Full Text Available The identity of  Euphorbia gummifera Boiss. and  E. gregaria Marl, is discussed and a new species, E. damarana Leach, is described. A key to the species including  E. carunculifera Leach from southern Angola and a map showing their distribution are provided. The possible significance of these species in the phylogeny of the genus is also discussed.

  9. Acute renal failure by ingestion of Euphorbia paralias

    Directory of Open Access Journals (Sweden)

    Karima Boubaker

    2013-01-01

    Full Text Available Euphorbia paralias is known in traditional medicine as an anti-inflammatory agent, a purgative and for its local anesthetic property. To the best our knowledge, renal toxicity of this substance has not been previously reported. In this paper, we report the case of a 29-year-old male who developed renal damage following ingestion of Euphorbia paralias. He had been on follow-up for nephrotic syndrome since 1986, although irregularly, with several relapses but each responding well to steroid therapy. A kidney biopsy had not been performed earlier due to refusal by the patient. He was off steroids since April 2008 because the patient developed osteoporosis. He was admitted with general malaise and oliguria to our department in May 2009, following repeated vomiting and watery diarrhea for three days. On examination, he was edematous but had normal vital signs except for a pulse rate of 120/min. Hemoglobin was only 5.5 g/dL but with normal white cell and platelet counts. Blood biochemistry showed evidence of advanced renal failure with a serum creatinine level of 1835 μmol/L and urea at 44.6 mmol/L, sodium of 132 μmol/L and potassium at 4.3 mmol/L. He had features of nephrotic syndrome with severe hypoproteinamia and 24-h urinary protein of 10.45 g. Ultrasonography revealed enlarged kidneys with a reduced echogenecity of the medulla and the papillae. Subsequently, after hemodialysis with blood transfusion, a kidney biopsy was performed that showed focal segmental glomerulosclerosis associated with an acute tubular injury. On intensive interrogation, the patient gave a history of ingesting boiled Euphorbia paralias as a native treatment for edema, ten days prior to the onset of the current illness. A diagnosis of acute renal failure (ARF resulting from the possible nephrotoxic effect of Euphorbia paralias poisoning was made. He was treated with intermittent hemodialysis and corticosteroids. Serum creatinine values improved after 48 days. At six

  10. Acute renal failure by ingestion of Euphorbia paralias.

    Science.gov (United States)

    Boubaker, Karima; Ounissi, Mondher; Brahmi, Nozha; Goucha, Rym; Hedri, Hafedh; Abdellah, Taieb Ben; El Younsi, Fethi; Maiz, Hedi Ben; Kheder, Adel

    2013-05-01

    Euphorbia paralias is known in traditional medicine as an anti-inflammatory agent, a purgative and for its local anesthetic property. To the best our knowledge, renal toxicity of this substance has not been previously reported. In this paper, we report the case of a 29-year-old male who developed renal damage following ingestion of Euphorbia paralias. He had been on follow-up for nephrotic syndrome since 1986, although irregularly, with several relapses but each responding well to steroid therapy. A kidney biopsy had not been performed earlier due to refusal by the patient. He was off steroids since April 2008 because the patient developed osteoporosis. He was admitted with general malaise and oliguria to our department in May 2009, following repeated vomiting and watery diarrhea for three days. On examination, he was edematous but had normal vital signs except for a pulse rate of 120/min. Hemoglobin was only 5.5 g/dL but with normal white cell and platelet counts. Blood biochemistry showed evidence of advanced renal failure with a serum creatinine level of 1835 μmol/L and urea at 44.6 mmol/L, sodium of 132 μmol/L and potassium at 4.3 mmol/L. He had features of nephrotic syndrome with severe hypoproteinamia and 24-h urinary protein of 10.45 g. Ultrasonography revealed enlarged kidneys with a reduced echogenecity of the medulla and the papillae. Subsequently, after hemodialysis with blood transfusion, a kidney biopsy was performed that showed focal segmental glomerulosclerosis associated with an acute tubular injury. On intensive interrogation, the patient gave a history of ingesting boiled Euphorbia paralias as a native treatment for edema, ten days prior to the onset of the current illness. A diagnosis of acute renal failure (ARF) resulting from the possible nephrotoxic effect of Euphorbia paralias poisoning was made. He was treated with intermittent hemodialysis and corticosteroids. Serum creatinine values improved after 48 days. At six months following the

  11. Comparative nutritional value and antimicrobial activities between three Euphorbia species growing in Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Amani S. Awaad

    2017-12-01

    Full Text Available Plants are excellent sources of nutrition and highly bioactive substances that might use in the development of new drugs and pharmaceutical agents. Three species of the Genus Euphorbia (Family Euphorpiaceae, namely; Euphorbia granulata Forssk, Euphorbia helioscobia L., and Euphorbia hirta Linn growing in Ryiadh, KSA were air-dried, powdered, and their active materials were extracted with alcohol. The nutritional value phytochemical constituents and antimicrobial activity of the plants were determined. The chemical contents were similar in the three species; however, lipid profile of the plants showed that the stearic acid and lignoceric acid were detected only in E. helioscopia and E. hirta, while palmitoleic acid was detected only in E. hirta. The percentage of unsaturated fatty acid methyl esters were 52.48%, 69.39% and 66.52% in Euphorbia granulate, Euphorbia helioscobia, E. hirta, respectively. Three compounds, 1-ethoxypentacosane, heptacosan-1-ol and β-sitosterol were isolated from the three plant extracts and identified using different spectroscopic analysis. The percentage of crude protein was 43.65%, 25.00% and 18.75% in E. granulata, E. helioscobia, and E. hirta, respectively. The free amino acids and amino acid composition were quantitatively determined using amino acid analyzer. All the plant extracts were active against bacterial and fungal test organisms, however, the antimicrobial activity were varied according to both the Euphorbia species and the test organism.

  12. Functional connection between intracellular and extracellular secretion in species of Euphorbia genus.

    Science.gov (United States)

    Tóth-Soma, L T; Gulyás, S; Szegletes, Z

    1993-01-01

    In species of the Euphorbia genus the intracellular latex-secretion and the extracellular nectar-secretion are anatomically connected. The functional connection of the secretional systems was proved to be probable by TLC and GC-MSD. The chemical composition of Euphorbia latex and honey was examined with these analytical methods. In our research, the comparative chemical analysis of the latex and the honey of two Euphorbia species (Euphorbia cyparissias L., Euphorbia seguieriana Necker.) was discharged. These species are unusually good melliferous plants in Hungary. Four chemical components that can be found both in the latex and in the honey were detected with ultraviolet light (254 nm), and three general alkaloid reagents (Dragendorff, Meyer and 1% Ce(SO4)2 in 2n H2SO4) were detected by TLC. By means of mass spectrum generated by GC-MSD, the following compounds of Euphorbia honey were identified: butyl-2-methylpropyl phtalat, hexadecane acid, diheptyl phtalat, bis (2-ethyl-hexyl) phtalat, benzenedicarboxylic acid decyl-hexyl ester, benzenedicarboxylic acid isodecyl-octyl ester. The first compounds can also be found in the latex of both examined Euphorbia species. This partial correspondence in the composition of the latex and the honey led to results that suggest a further, functional connection between the two, anatomically connected secretional systems.

  13. Biochemical Evaluation and Green Synthesis of Nano Silver Using Peroxidase from Euphorbia (Euphorbia amygdaloides and Its Antibacterial Activity

    Directory of Open Access Journals (Sweden)

    Semra Cicek

    2015-01-01

    Full Text Available Silver nanoparticles are used an increased attention for various biomedical and medical applications. In this study, green synthesis of silver nanoparticles was made with simple method by using peroxidase enzyme partially purified from Euphorbia (Euphorbia amygdaloides plant. Optimum pH, temperature and time period were determined to obtain silver nanoparticles using the peroxidase enzyme. The result shows that higher silver nanoparticle was synthesized for 4 hours and at 20°C and pH 8. Also, optimal concentration of metal ions was found as 0.5 mM. The synthesized silver nanoparticles were characterized by UV spectrum, scanning electron microscope (SEM and X-ray diffraction. Antibacterial activity of silver nanoparticles was measured against some microorganisms such as Serratia marcescens, Yersinia pseudotuberculosis, Klebsiella pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Pseudomonas aeruginosa, Salmonella typhimurium, Listeria monocytogenes, and Escherichia coli. Synthesized silver nanoparticles have wide spectrum antibacterial activity in low concentration and may be a good alternative therapeutic approach in medicine and pharmaceutical fields in future.

  14. Euphorbia esula Biocontrol : Achieving Management Objectives : Preliminary Analysis of 1998 Data

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In spring 1998, studies were initiated to assess the ecological impacts of the invasive non-native species leafy spurge (Euphorbia esula) on rangeland and natural...

  15. Euphorbia esula : Achieving Management Objectives : Analysis of 1998-2002 Data

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Euphorbia esula is a long-lived perennial plant with an extensive root system. The extent of the root system makes the plant highly resistant to most traditional...

  16. Minor ent-abietane diterpenoids from Euphorbia guyoniana.

    Science.gov (United States)

    Haba, Hamada; Marcourt, Laurence; Benkhaled, Mohammed; Long, Christophe

    2013-11-01

    Three new abietane-type diterpenoids: ent-abieta-8,11,13-trien-16-ol (1), ent-abieta-8,11,13-trien-11,16-diol (2) and 11,12-dihydroxy-7-oxo-ent-abieta-8,11,13-trien-16-oic acid methyl ester (3), in addition to three known triterpenoids: euphol (4), 24,25-epoxycycloartanol (5) and beta-sitosterol O-beta-D-glucoside (6) were isolated from the chloroform extract of the roots of Euphorbia guyoniana. Structures of the isolated compounds were established on the basis of spectroscopic analyses, including 1D and 2D homo and heteronuclear NMR experiments and ESIMS, and comparison with literature data.

  17. Euphorbia latex: a possible source of hydrocarbons and rubber

    Energy Technology Data Exchange (ETDEWEB)

    Viaud, P.; Teisseire, D.

    1975-01-01

    Illustrated descriptions are given of 36 plants of potential economic value in underdeveloped tropical countries, classified by use. The plants are either wild or cultivated on a fairly local scale. Accounts of limitations and special requirements and lists of references, research contacts and sources of germ plasm are included for each species. The following tree and shrub species are included: Cnidoscolus aconitifolius, C. chayamansa and hearts of several edible palm species including Euterpe edulis (vegetables); Durio species, Garcinia mangostana, Solanum quitoense, Bactris gaspiaes, Citrus grandis, Annona muricata and Pourouma cecropiaefolia (fruits); Orbignya martiana, Caryocar species, Jessenia polycarpa and Simmondsia chinensis (oil seeds); Acacia albida, Brosimum alicastrum, Cassia sturtii, Atriplex species and Prosopis tamarungo (forage (browse)); Mauritia flexuosa (fruit, wood, etc.); Euphorbia antisyphilitica (wax); and Parthenium argentatum (rubber).

  18. von Willebrand Disease

    Science.gov (United States)

    ... for type 1 von Willebrand disease is called desmopressin. It causes a temporary increase in the von ... injection or by being sniffed into the nose. Desmopressin may also help some people with type 2 ...

  19. Interaktive Visualisierung von Strukturmechaniksimulationen

    OpenAIRE

    Sommer, Ove

    2003-01-01

    A) Motivation und Problemstellung Der Computer ist heute eines der wichtigsten Hilfsmittel beim Entwurf und der Entwicklung von Fahrzeugen. Zunächst wurde er von Konstrukteuren für das Computer Aided Design (CAD) von virtuellen Fahrzeugmodellen eingesetzt. Inzwischen ist er in vielen anderen Bereichen der Fahrzeugentwicklung unentbehrlich geworden: der Entwicklungszyklus von Automobilen ist durch die Computer-gestützte numerische Simulation substanziell verkürzt worden. An virtuellen Prot...

  20. Euphorbia kansui Attenuates Insulin Resistance in Obese Human Subjects and High-Fat Diet-Induced Obese Mice

    Directory of Open Access Journals (Sweden)

    Seung-Wook Lee

    2017-01-01

    Full Text Available Background. Obesity is a main cause of insulin resistance (IR, metabolic syndrome, and fatty liver diseases. This study evaluated Euphorbia kansui radix (Euphorbia as a potential treatment option for obesity and obesity-induced IR in obese human and high-fat diet- (HFD- induced obese mice. Methods. In the human study, we analyzed the body weight change of 14 patients who took a single dose of 6 g of Euphorbia powder. In the animal study, male mice were divided into three groups: normal chow, HFD, and Euphorbia (high-fat diet and 100 mg/Kg Euphorbia once per week. Body weight, epididymal fat pad weight, fasting blood glucose, fasting insulin, HOMA-IR, and oral glucose tolerance test were measured. Also, macrophage infiltration and expression of CD68, tumor necrosis factor- (TNF- α, interferon- (IFN- γ, and interleukin- (IL- 6 genes in the liver and adipose tissue were analyzed. Results. The human study showed that Euphorbia has a potential effect on body weight loss. In the in vivo study, body weight, epididymal fat weight, glucose level, IR, expression of CD68, TNF-α, IFN-r, and IL-6 genes, and macrophages in liver and adipose tissue were significantly reduced by Euphorbia. Conclusions. These results suggest that Euphorbia attenuates obesity and insulin resistance via anti-inflammatory effects.

  1. Effect of Euphorbia hirta plant leaf extract on immunostimulant response of Aeromonas hydrophila infected Cyprinus carpio

    Science.gov (United States)

    Sukumaran, NatarajaPillai

    2014-01-01

    The main objective of the present study is to improve the immune power of Cyprinus carpio by using Euphorbia hirta plant leaf extract as immunostimulants. The haematological, immunological and enzymatic studies were conducted on the medicated fish infected with Aeromonas hydrophila pathogen. The results obtained from the haematological studies show that the RBC count, WBC count and haemoglobin content were increased in the infected fish at higher concentration of leaf extract. The feeds with leaf extract of Euphorbia hirta were able to stimulate the specific immune response by increasing the titre value of antibody. It was able to stimulate the antibody production only up to the 5th day, when fed with higher concentrations of (25 g and 50 g) plant leaf extract. The plant extract showed non-specific immune responses such as lysozyme activity, phagocytic ratio, NBT assay, etc. at higher concentration (50 g) and in the same concentration (50 g), the leaf extract of Euphorbia hirta significantly eliminated the pathogen in blood and kidney. It was observed that fish have survival percentage significantly at higher concentration (50 g) of Euphorbia hirta, when compared with the control. The obtained results are statistically significant at P < 0.05 and P < 0.01 levels. This research work suggests that the plant Euphorbia hirta has immunostimulant activity by stimulating both specific and non-specific immunity at higher concentrations. PMID:25405077

  2. Is folklore use of Euphorbia helioscopia devoid of toxic effects?

    Science.gov (United States)

    Saleem, Uzma; Ahmad, Bashir; Ahmad, Mobasher; Erum, Alia; Hussain, Khalid; Irfan Bukhari, Nadeem

    2016-01-01

    To evaluate acute toxic effects of Euphorbia helioscopia in order to assure the safety and usefulness of herbal remedy. The Organization for Economic Cooperation and Development (OECD) for chemical testing guidelines No. 425 for acute oral toxicity testing were followed in this study. Mice were divided into three groups (n = 5). Group I served as control. Groups II and III were administered methanol extract of E. helioscopia leaves and latex orally at dose of 2000 mg/kg, respectively. Then, all the animals were observed for two weeks. Blood sampling was done by cardiac puncture after 14 days from each group for biochemical analysis. Histopathology was performed to find out any microscopic lesion in vital organs. LD50 was found greater than 2000 mg/kg. There was decrease in cholesterol, triglycerides, LDL and VLDL levels of latex and leaves with methanol extract-treated animals, with respect to control indicating plant's hypolipidemic effect. On macroscopic examination, no lesions were found on vital organs, such as liver, heart and kidney; and normal architecture was observed on microscopic examination. On the basis of results, it was concluded that methanol extract of E. helioscopia leaves and latex were devoid of toxic effects in acute toxicity study.

  3. Chemical Constituents of Euphorbia Polyacantha Boiss. and their Immunomodulatory Properties

    Directory of Open Access Journals (Sweden)

    Gihan O. M. ELhassan

    2015-01-01

    Full Text Available Phytochemical investigation on the stem of Euphorbia polyacantha Boiss. (Euphorbiaceae afforded a new anthraquinone named as 1, 8-dihydroxy -3- (hydroxyl methyl -5- methoxy anthracene- 9,10- dione (1 along with three known compounds, aloe emodin (2 , 3, 4, 3 ¢ –tri-O-methyl ellagic acid (3, and 3,3 ¢ ,4, 4 ¢ - tetra-O-methyl ellagic acid (4. Their structures were determined on the basis of IR, 1D- and 2D- NMR spectroscopy and mass spectrometry analysis. The effect of isolated compounds on oxidative burst of neutrophils and T-cell proliferation response was studied. Compounds 3 and 1 displayed strong oxidative burst inhibitory activity with IC 50 2 ± 0 and 3.5 ± 1.1 µg/mL respectively, whereas they moderately inhibited the T-cell proliferation with IC 50 28.5 ± 1.8 and 22.5 ± 2.0 µg/mL respectively. Compound 2 was relatively inactive with IC 50 43.2 μg/mL in oxidative burst and >50 μg/mL in case of T-cell proliferation. This is the first report on the phytochemical profile and biological activity of E. polyacantha.

  4. Chitinase III in Euphorbia characias latex: Purification and characterization.

    Science.gov (United States)

    Spanò, Delia; Pospiskova, Kristyna; Safarik, Ivo; Pisano, Maria Barbara; Pintus, Francesca; Floris, Giovanni; Medda, Rosaria

    2015-12-01

    This paper deals with the purification of a class III endochitinase from Euphorbia characias latex. Described purification method includes an effective novel separation step using magnetic chitin particles. Application of magnetic affinity adsorbent noticeably simplifies and shortens the purification procedure. This step and the subsequently DEAE-cellulose chromatography enable to obtain the chitinase in homogeneous form. One protein band is present on PAGE in non-denaturing conditions and SDS-PAGE profile reveals a unique protein band of 36.5 ± 2 kDa. The optimal chitinase activity is observed at 50 °C, pH 5.0. E. characias latex chitinase is able to hydrolyze colloidal chitin giving, as reaction products, N-acetyl-D-glucosamine, chitobiose and chitotriose. Moreover, we observed that calcium and magnesium ions enhance chitinase activity. Finally, we cloned the cDNA encoding the E. characias latex chitinase. The partial cDNA nucleotide sequence contains 762 bp, and the deduced amino acid sequence (254 amino acids) is homologous to the sequence of several plant class III endochitinases. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Lernen von und bei Max von Laue

    Science.gov (United States)

    Thiessen, P. A.

    Erinnerungen an die Entstehungsgeschichte und die Frühzeiten der Röntgenstrukturanalyse.Translated AbstractLearning at Max von LaueRemembrances of the historical rise and the early times of X-ray structure analysis.

  6. Terpenoid biosynthesis in Euphorbia lathyris and Copaifera spp

    Energy Technology Data Exchange (ETDEWEB)

    Skrukrud, C.L.

    1987-07-01

    Biosynthesis of triterpenoids by isolated latex of Euphorbia lathyris was investigated. The rate of in vitro incorporation of mevalonic acid into triterpenoids was thirty times greater than acetate incorporation indicating that the rate-limiting step in the pathway occurs prior to mevalonate. Both HMG-CoA reductase (EC 1.1.1.34) and HMG-CoA lyase (EC 4.1.3.4) activities were detected in isolated latex. HMG-CoA reductase was localized to a membrane-bound fraction of a 5000g pellet of latex. The rate of conversion of HMG-CoA to mevalonate by this enzyme is comparable to the overall rate of acetate incorporation into the triterpenoids suggesting that this enzyme is rate-determining in the biosynthesis of triterpenoids in E. lathyris latex. HMG-CoA reductase of E. lathyris vegetative tissue was localized to the membrane-bound portion of a particulate fraction (18,000g), and was solubilized by treatment with 2% polyoxyethylene ether W-1. Differences in the optimal pH for activity of HMG-CoA reductase from the latex and vegetative tissue suggest that isozymes of the enzyme may be present in the two tissue types. Studies of the incorporation of various precursors into leaf discs and cuttings taken from Copaifera spp. show differences in the rate of incorporation into Copaifera sesquiterpenes suggesting that the site of sesquiterpene biosynthesis may differ in its accessibility to the different substrates and/or reflecting the metabolic controls on carbon allocation to the terpenes. Mevalonate incorporation by Copaifera langsdorfii cuttings into sesquiterpenes was a hundred-fold greater than either acetate or glucose incorporation, however, its incorporation into squalene and triterpenoids was also a hundred-fold greater than the incorporation into sesquiterpenes. 119 refs., 58 figs., 16 tabs.

  7. Euphorbia tirucalli modulates gene expression in larynx squamous cell carcinoma.

    Science.gov (United States)

    Franco-Salla, Gabriela Bueno; Prates, Janesly; Cardin, Laila Toniol; Dos Santos, Anemari Ramos Dinarte; Silva, Wilson Araújo da; da Cunha, Bianca Rodrigues; Tajara, Eloiza Helena; Oliani, Sonia Maria; Rodrigues-Lisoni, Flávia Cristina

    2016-05-21

    Some plants had been used in the treatment of cancer and one of these has attracted scientific interest, the Euphorbia tirucalli (E. tirucalli), used in the treatment of asthma, ulcers, warts has active components with activities scientifically proven as antimutagenic, anti-inflammatory and anticancer. We evaluate the influence of the antitumoral fraction of the E. tirucalli latex in the larynx squamous cell carcinoma (Hep-2), on the morphology, cell proliferation and gene expression. The Hep-2 cells were cultivated in complete medium (MEM 10 %) and treated with E. tirucalli latex for 1, 3, 5 and 7 days. After statistically analyzing the proliferation of the tested cells, the cells were cultivated again for RNA extraction and the Rapid Subtractive Hybridization (RaSH) technique was used to identify genes with altered expression. The genes found using the RaSH technique were analyzed by Gene Ontology (GO) using Ingenuity Systems. The five genes found to have differential expression were validated by real-time quantitative PCR. Though treatment with E. tirucalli latex did not change the cell morphology in comparison to control samples, but the cell growth was significantly decreased. The RaSH showed change in the expression of some genes, including ANXA1, TCEA1, NGFRAP1, ITPR1 and CD55, which are associated with inflammatory response, transcriptional regulation, apoptosis, calcium ion transport regulation and complement system, respectively. The E. tirucalli latex treatment down-regulated ITPR1 and up-regulated ANXA1 and CD55 genes, and was validated by real-time quantitative PCR. The data indicate the involvement of E. tirucalli latex in the altered expression of genes involved in tumorigenic processes, which could potentially be applied as a therapeutic indicator of larynx cancer.

  8. Seed-Robbing between Ant Species Intervenes in the Myrmecochory of Euphorbia characias (Euphorbiaceae)

    OpenAIRE

    Xavier Espadaler; Crisanto Gómez; David Suñrer

    1995-01-01

    A case of interference competition in which some ant species (Messor barbarus and Aphaenogaster senilis) rob seeds of Euphorbia characias from other ants (especially Tapinoma nigerrimum) is reported. Seed robbing is here regarded as a possible natural impediment to myrmecochory as it may interfere with the seedling recruitment process of the myrmecochorous plant.

  9. Demonstration of the economic feasibility of plant tissue culture for jojoba (Simmondsia chinensis) and Euphorbia spp

    Energy Technology Data Exchange (ETDEWEB)

    Sluis, C.

    1980-09-01

    The economic feasibility of plant tissue culture was demonstrated as applied to two plants: jojoba (Simmondsia chinensis) and Euphorbia spp. The gopher weed (Euphorbia lathyris) was selected as the species of Euphorbia to research due to the interest in this plant as a potential source of hydrocarbon-like compounds. High yield female selections of jojoba were chosen from native stands and were researched to determine the economic feasibility of mass producing these plants via a tissue culture micropropagation program. The female jojoba selection was successfully mass produced through tissue culture. Modifications in initiation techniques, as well as in multiplication media and rooting parameters, were necessary to apply the tissue culture system, which had been developed for juvenile seedling tissue, to mature jojobas. Since prior attempts at transfer of tissue cultured plantlets were unsuccessful, transfer research was a major part of the project and has resulted in a system for transfer of rooted jojoba plantlets to soil. Euphorbia lathyris was successfully cultured using shoot tip cultures. Media and procedures were established for culture initiation, multiplication of shoots, callus induction and growth, and root initiation. Well-developed root systems were not attained and root initiation percentages should be increased if the system is to become commercially feasible.

  10. Beheersing en bestrijding van Botrytis cinerea en van Penicillium in Euphorbia fulgens

    NARCIS (Netherlands)

    Wubben, J.P.; Hazendonk, A.; Bosker, I.; Slootweg, C.; Hoope, ten M.

    2002-01-01

    De bloeiwijze van Euphorbia fulgens kent twee belangrijke schimmelbelagers, die problemen in de teelt veroorzaken: Botrytis cinerea en Penicillium. B. cinerea geeft schade in de vorm van smet of pokken, die op de bloemblaadjes verschijnen. Dit zijn kleine donkerbruine/zwarte plekjes van ongeveer 1

  11. The involvement of amino acids in latex lipid synthesis in Euphorbia lathyris seedlings

    NARCIS (Netherlands)

    Groeneveld, H.W.; Elings, J.

    1984-01-01

    The breakdown of triglycerides and proteins in the endosperm of Euphorbia lathyris was assayed in a 14 day germination period. Six days after germination, the average daily production was 2.7 μmol of amino acids. Arginine, glutamine, asparagine and glutamic acid accounted for 53% of the total amino

  12. Repellence and toxicity of plant essential oils to the potato aphid, Macrosiphum euphorbiae

    NARCIS (Netherlands)

    Munneke, M.E.; Bruin, de A.; Moskal, J.R.; Tol, van R.W.H.M.

    2004-01-01

    Several plant essential oils were tested for their effect on behaviour and mortality of M. euphorbiae. Olfactory and contact experiments were performed to study these effects. We found that host plant and formulation of the different oils have a strong influence on repellence and mortality of the

  13. New Compounds from Euphorbia helioscopia and Absolute Configuration Determination by Computational Methods

    Energy Technology Data Exchange (ETDEWEB)

    He, Jiangbo; Zhu, Hua Jie; Luo, Gui Fen; Li, Yan; Cheng, Yong Xian [Chinese Academy of Sciences, Kunming (China); Chen, Hao; Chen, Shaopeng; Lu, Xin; Zhou, Guochun [Chinese Academy of Sciences, Guangzhou (China); Liu, Guang Ming [Dali University, Dali (China)

    2010-08-15

    The whole plant of Euphorbia helioscopia is an important traditional Chinese medicine. Fom its BuOH soluble extract, one new lactam, three new terpenoids including a new naturally occurring compound, and three known compounds were isolated. Their structures were identified by spectroscopic evidences. In particular, the absolute configurations of side chain of compounds 1 and 2 were determined using computational methods.

  14. Inoculation of cyclamen (Cyclamen persicum) and poinsettia (Euphorbia pulcherrima) with arbuscular mycorrhizal fungi and Trichoderma harzianum

    Czech Academy of Sciences Publication Activity Database

    Dubský, M.; Šrámek, F.; Vosátka, Miroslav

    2002-01-01

    Roč. 48, č. 2 (2002), s. 63-68 ISSN 0370-663X Institutional research plan: CEZ:AV0Z6005908 Keywords : Cyclamen persicum * Euphorbia pulcherrima * inoculation Subject RIV: EF - Botanics Impact factor: 0.333, year: 2002

  15. Inventory and analysis of leafy spurge (Euphorbia esula) sites: a feasibility study

    Science.gov (United States)

    Richard E. Francis; Meredith J. Morris; Richard J. Myhre; Daniel L. Noble

    1980-01-01

    Leafy spurge (Euphorbia esula L.) infests more than 2.25 million acres of agricultural and range lands in the United States and had an economic impact of $10.5 million in 1978 (Noble et al. 1979). The most widespread and heaviest areas of infestation are in the northern and central Great Plains. However, quantitative information and compatible...

  16. In vitro evaluation of the effect of Euphorbia kamerunica latex on the ...

    African Journals Online (AJOL)

    The effect of Euphorbia kamerunica latex on the blood of albino rat (Rattus novergicus) was studied. Two different samples were prepared, one with 10% E. kamerunica latex in blood of albino rat and the other, whole blood. Blood from each of the two samples was analyzed haematologically for the packed cell volume ...

  17. [Analysis and comparison of trace elements of herba euphorbiae humifusae in different periods by microwave digestion-atomic absorption spectroscopy].

    Science.gov (United States)

    Xiong, Wei; Cai, Miao-zhen; Wang, Hong; Yu, Rui-peng; Cheng, Cun-gui

    2010-07-01

    Herba euphorbiae humifusae is the dried whole plant of Euphorbia humi fusa Willd. that belongs to euphorbiaceae. In the present paper, the microwave digestion procedure was used to digest herba euphorbiae humifusae collected in different periods, and then flame atomic absorption spectrometry (FAAS) was used to determine the contents of eight kinds of trace elements of herba euphorbiae humifusae in different periods, and the change in the contents of trace elements at different times was studied and analysed. The results showed that of all the trace elements of herba euphorbiae humifusae in different periods, element Fe was the highest in June, element K was in August at the highest level, element Mn reached the highest content in September, elements Na and Ca were dividedly at the highest content in October and November, and in December the highest content elements were Zn, Cu and Mg. In one word, the change of Na and Ca was jumping, while the change of Cu and Zn was comparatively mild. The results provide scientific basis for the time of collection of herba euphorbiae humifusae.

  18. Growth analysis of three species weeds Euphorbia genus = Análise de crescimento de espécies daninhas do gênero Euphorbia

    Directory of Open Access Journals (Sweden)

    Débora Teresa Ferreira

    2017-06-01

    Full Text Available In sugarcane plantations, species of the genus Euphorbia are reported as weeds able to reduce productivity by up to 85%. Planning the correct strategies for controlling these plants requires knowledge of their biology and growth. The aim of this work therefore, was to evaluate the growth of three weed species of the genus Euphorbia occurring in sugarcane plantations. The study was carried out in a greenhouse, using a completely randomised experimental design in a scheme of lots subdivided over time, with five replications. The factors were three species of Euphorbia (E. heterophylla, E. hyssopifolia and E. hirta and 13 periods of evaluation 14, 21, 28, 35, 42, 49, 56, 63, 70, 77, 84, 91 and 98 days after sowing (DAS. Each evaluation measured plant height (PH, leaf area (LA, number of leaves (NL and total dry matter (TDM. From the mean values for shoot dry matter (SDM, TDM and LA, the absolute growth rate (AGR and relative growth rate (RGR, leaf area ratio (LAR, and leaf weight ratio (LWR were calculated. Data were submitted to analysis of variance and non-linear regression. E. heterophylla displayed greater PH up to 63 DAS, from this point E. hyssopifolia obtained greater height among the species under study. E. heterophylla was noteworthy for having a greater accumulation of LA, TDM and AGR among the studied species, followed by E. hyssopifolia and E. hirta. Maximum growth in the species under evaluation was at 77 DAS. Among the species, E. heterophylla displays greater growth and development. = Nos canaviais, espécies do gênero Euphorbia são relatadas como plantas daninhas capazes de reduzir a produtividade em até 85%. Para traçar estratégias corretas de controle dessas plantas é necessário o conhecimento tanto da sua biologia quanto do seu crescimento. Assim, objetivou-se com este trabalho avaliar o crescimento de três espécies daninhas do gênero Euphorbia ocorrentes nos canaviais. O estudo foi realizado em casa de vegeta

  19. von Willebrand Disease

    Science.gov (United States)

    ... the condition. For example, the school nurse, teacher, daycare provider, coach, or any leader of afterschool activities ... MedlinePlus) Von Willebrand Disease (MedlinePlus) Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting ...

  20. Carl von Clausewitz

    DEFF Research Database (Denmark)

    Højrup, Thomas

    2009-01-01

    Forskningsbaseret præsentation af Carl von Clausewitz' krigsteori og dens betydning for statsbegrebet og udviklingen af teori om statsdannelse og statssystem. Krigsbegrebets betydning for politikbegrebet ekspliciteres, og de indre relationer imellem de to begreber demonstreres med konkrete eksemp...

  1. Ellis Von Creveld Syndrome

    Directory of Open Access Journals (Sweden)

    Afshar H

    1999-01-01

    Full Text Available One patient with Ellis Von Creveld syndrome contains: dwarfism, congenital heart"ndisease, ectodermal dysplasia, polyductyly, an abnormally wide labial frenum and maxillary"nmolars with single root.

  2. Germination and mycelial growth of Bipolaris euphorbiae Muchovej & Carvalho as influenced by herbicides and surfactants

    Directory of Open Access Journals (Sweden)

    Nemoto Marta Cecília Mallasen

    2002-01-01

    Full Text Available Bipolaris euphorbiae Muchovej & Carvalho can be combined with herbicide in order to control a large spectrum of weed species, being a strong candidate for the biocontrol of Euphorbia heterophylla L. (milk weed. The fungus release can be combined with herbicide in order to control a broader spectrum of weed species. Thus, laboratory experiments were set up to study the feasibility of using tank mixes of B. euphorbiae spores with herbicides or surfactants recommended for soybean. Mycelial growth and conidia germination were evaluated in PDA medium enriched with the herbicides oxasulfuron (80 g/ha, glyphosate (4 L/ha, bentazon (1.5 L/ha, fomesafen (1 L/ha, chlorimuron-ethyl (80 g/ha, lactofen (1 L/ha and imazetaphyr (1 L/ha, and the surfactants Energic (2 ml/L, Aterbane (2.5 ml/L, Silwet L-77Ag (1 ml/L, Herbitensil (2 ml/L and Natur L'óleo (10 ml/L. Dilution of the herbicides at 50% and 25% were evaluated based on solution consumption of 300 L/ha. The surfactants were evaluated only in the recommended concentrations. Mycelial growth was not affected by bentazon and fomesafen and slightly by oxasulfuron. However, glyphosate and the surfactants Energic, Herbitensil and Aterbane strongly reduced its growth. The reduction observed on imazetaphyr enriched medium was intermediate and the Natur L'óleo promoted mycelial growth. All of the surfactants allowed B. euphorbiae conidia germination equivalent to that reached in the presence of water. Energic and Herbitensil caused an expressive retardation on spore germination. The germinative process only began after 120 minutes in the presence of Herbitensil. In relation to the herbicides, it was observed that only in the presence of glyphosate and imazetaphyr the conidia germination did not follow the trend of the treatment with water.

  3. Assessment of immunomodulatory activity of Euphorbia hirta L.

    OpenAIRE

    Ramesh K.; Padmavathi K

    2010-01-01

    Immune system is the major target for development of treatment strategies to improve the management of infections. Many species of Indian medicinal plants have been reported to possess active principles with immunomodulating properties. Euphorbia hirta, a pantropic herb has been reported to be pharmacologically active. This study reports one another not widely reported property of the plant, immunomodulatory activity, which has been proved using simple techniques like the macrophage activity ...

  4. Genetic characterization of a red color morph of Euphorbia esula subsp. esula (Euphorbiaceae) in the floodplains of Saône (Eastern France)

    Science.gov (United States)

    The invasive leafy spurge, Euphorbia esula L (Euphorbiaceae) is an The invasive leafy spurge, Euphorbia esula L (Euphorbiaceae) is an emerging weed in the floodplains of the Val de Saône France, that displaces native flora and desirable forage species by forming dense monotypic stands. It is conside...

  5. Von Braun Fountain

    Science.gov (United States)

    1999-01-01

    A fountain representing a rocket launch was dedicated in the Von Braun courtyard outside of Building 4200 at Marshall Space Flight Center during the weekend celebrating the 30th arniversary of the Apollo 11 lunar landing. On hand for the festivities were many of the Saturn and Apollo astronauts.

  6. Rhizostomeen von Manila

    NARCIS (Netherlands)

    Stiasny, G.

    1924-01-01

    Die hier beschriebene kleine Scyphomedusen-Sammlung wurde von Herrn Director P. B. Sivickis, Dept. of Zoology, University of Philippines, Manila, dem Rijksmuseum van Natuurlijke Historie in Leiden überwiesen. Das Material wurde im December 1922 in Manila-bay gefischt und befindet sich in bestem

  7. Karman, Prof. Theodore von

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1961 Honorary. Karman, Prof. Theodore von. Date of birth: 11 May 1881. Date of death: 6 May 1963. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the ...

  8. Schmetterlinge von Madeira

    NARCIS (Netherlands)

    Martin, K.

    1941-01-01

    Wer auf einer ozeanischen Insel Schmetterlinge sammeln will, darf seine Erwartungen nicht zu hoch spannen; aber dennoch waren meine Frau und ich sehr enttäuscht, als uns auf einer Reise nach Madeira von einer dort angesessenen, gebildeten Dame gesagt wurde, sie habe auf der Insel niemals einen

  9. Biocrude crop production in arid lands. [Calotropis procera, Chrysothamus paniculatus, Euphorbia lathyris, Grindelia camporum

    Energy Technology Data Exchange (ETDEWEB)

    McLaughlin, S.P.; Kingsolver, B.E.; Hoffmann, J.J.

    1983-01-01

    Published and unpublished estimates of land and water requirements and energy yield were used to prepare energy budgets for 4 potential biocrude (liquid fuel) crops in the SW USA: the perennials Calotropis procera and Chrysothamnus paniculatus and the annuals Euphorbia lathyris and Grindelia camporum. Estimated annual costs are examined and discussed for an operation processing 300,000 t/yr. The cheapest energy was produced by C. paniculatus, although it required the largest land area. The paper emphasizes that selecting for biocrude content (biomass quality) of plants may be at the expense of productivity (quantity) since the 2 have been shown to be inversely related in many cases. 8 references.

  10. [Dermatitis and conjunctivitis after contact with Euphorbia myrsinites (wolf's milk extract)--a case report].

    Science.gov (United States)

    Eberle, M M; Erb, C; Flammer, J; Meyer, P

    1999-09-01

    Fresh sap of euphorbiaceae leads to a toxic burn of the skin and the eyes. Since years the sap of euphorbiaceae has been used in the treatment of different kinds of verrucas. After contact with the sap of Euphorbia myrsinites three children developed a toxic dermatitis. In addition, the youngest girl showed a conjunctivitis and an occlusion of the right eye. Phorbolesters are considered to be responsible for the toxicity of the euphorbiaceae. All three children have resulted in a restitutio ad integrum. This case report is demonstrating the danger of toxic burn of this kind of plant.

  11. POTENSI ANTIMIKROBIA KRIM EKSTRAK RANTING PATAH TULANG (Euphorbia tirucalli Linn. TERHADAP Propionibacterium acnes ATCC 11827 DAN Candida albicans ATCC 24433

    Directory of Open Access Journals (Sweden)

    Melina Scandinovita Setiorini

    2016-04-01

    extracts with cream for testing Candida albicans.The final results were 10% test extract had MIC to Propionibacterium acnes and 6% test extract had MIC in cream to Candida albicans. Keywords: Euphorbia tirucalli L., DMSO, Thymol, antimicrobial potency, cream (o/w, Propionibacterium acnes, Candida albicans

  12. Method for increasing the synthesis and accumulation of natural hydrocarbons derived from terpenoid metabolism in the euphorbia lathyris plant

    OpenAIRE

    Balaguer Zamora, Begoña; Castelblanque Soriano, Lourdes; Martí-Ibáñez, María Cristina; Ramírez García, Vicente; Vera, Pablo

    2011-01-01

    [EN] The invention relates to a method for obtaining triterpene-enriched biomass, characterised in that it comprises treating the plant Euphorbia lathyris with at least one jasmonate, preferably methyl jasmonate. The invention also relates to the resulting triterpene-enriched biomass, to the use thereof as a fuel source and to the method for obtaining said fuel.

  13. Use of biochar as peat substitute for growing substrates of Euphorbia × lomi potted plants

    Directory of Open Access Journals (Sweden)

    Vincenzo Dispenza

    2016-12-01

    Full Text Available Biochar from conifers wood was used in soilless culture as growing substrate alternative to peat for ornamental crops. Potted plants of Euphorbia × lomi Rauh cv. ‘Ilaria’ were grown with different mixtures (v:v of brown peat and biochar in order to evaluate main physical and chemical characteristics of this biomaterial as well as its effect on plant growth, ornamental characteristics and nutrients uptake. Biochar addition to peat increased pH, EC and K content of the growing substrates, as well as air content and bulk density. Biochar content of substrates significantly affected plant growth and biomass partitioning: higher number of shoots and leaves, leaf area and leaf dry weight were recorded in plants grown in 40% peat-60% biochar, with respect to plants grown in 100% peat and secondarily in 100% biochar. Leaf chlorophyll content was higher in plants grown in 60% and 80% biochar, while biomass water use efficiency was higher with 60% biochar. Plant uptake of K and Ca increased as biochar content of the substrates increased. Hence, a growing substrate containing 40% brown peat and 60% conifers wood biochar was identified as the more suitable mixture allowing to have a high-quality production of Euphorbia × lomi potted plants.

  14. Biomimetic Synthesis of Silver Nanoparticles Using Endosymbiotic Bacterium Inhabiting Euphorbia hirta L. and Their Bactericidal Potential

    Directory of Open Access Journals (Sweden)

    Baker Syed

    2016-01-01

    Full Text Available The present investigation aims to evaluate biomimetic synthesis of silver nanoparticles using endophytic bacterium EH 419 inhabiting Euphorbia hirta L. The synthesized nanoparticles were initially confirmed with change in color from the reaction mixture to brown indicating the synthesis of nanoparticles. Further confirmation was achieved with the characteristic absorption peak at 440 nm using UV-Visible spectroscopy. The synthesized silver nanoparticles were subjected to biophysical characterization using hyphenated techniques. The possible role of biomolecules in mediating the synthesis was depicted with FTIR analysis. Further crystalline nature of synthesized nanoparticles was confirmed using X-ray diffraction (XRD with prominent diffraction peaks at 2θ which can be indexed to the (111, (200, (220, and (311 reflections of face centered cubic structure (fcc of metallic silver. Transmission electron microscopy (TEM revealed morphological characteristics of synthesized silver nanoparticles to be polydisperse in nature with size ranging from 10 to 60 nm and different morphological characteristics such as spherical, oval, hexagonal, and cubic shapes. Further silver nanoparticles exhibited bactericidal activity against panel of significant pathogenic bacteria among which Pseudomonas aeruginosa was most sensitive compared to other pathogens. To the best of our knowledge, present study forms first report of bacterial endophyte inhabiting Euphorbia hirta L. in mediating synthesizing silver nanoparticles.

  15. Identification of Phenolic Compounds and Evaluation of Antioxidant and Antimicrobial Properties of Euphorbia Tirucalli L.

    Directory of Open Access Journals (Sweden)

    Keline Medeiros de Araújo

    2014-03-01

    Full Text Available Bioactive compounds extracted from natural sources can benefit human health. The aim of this work was to determine total phenolic content and antioxidant activity in extracts of Euphorbia tirucalli L. followed by identification and quantification of the phenolic compounds, as well as their antibacterial activities. Antioxidant activities were determined by DPPH and ABTS•+ assay. Identification of phenolic compounds was performed using high-performance liquid chromatography (HPLC, and antimicrobial activities were verified by agar dilution methods and MIC values. Total phenolic content ranged from 7.73 to 30.54 mg/100 g gallic acid equivalent. Extracts from dry plants showed higher antioxidant activities than those from fresh ones. The DPPH EC50 values were approximately 12.15 μg/mL and 16.59 μg/mL, respectively. Antioxidant activity measured by the ABTS method yielded values higher than 718.99 μM trolox/g for dry plants, while by the Rancimat® system yielded protection factors exceeding 1 for all extracts, comparable to synthetic BHT. Ferulic acid was the principal phenolic compound identified and quantified through HPLC-UV in all extracts. The extracts proved effective inhibitory potential for Staphylococcus epidermidis and Staphylococcus aureus. These results showed that extracts of Euphorbia tirucalli L. have excellent antioxidant capacity and moderate antimicrobial activity. These can be attributed to the high concentration of ferulic acid.

  16. Colonization and diversification of the Euphorbia species (sect. Aphyllis subsect. Macaronesicae) on the Canary Islands.

    Science.gov (United States)

    Sun, Ye; Li, Yanshu; Vargas-Mendoza, Carlos Fabián; Wang, Faguo; Xing, Fuwu

    2016-09-29

    Diversification between islands and ecological radiation within islands are postulated to have occurred in the Euphorbia species (sect. Aphyllis subsect. Macaronesicae) on the Canary Islands. In this study, the biogeographical pattern of 11 species of subsect. Macaronesicae and the genetic differentiation among five species were investigated to distinguish the potential mode and mechanism of diversification and speciation. The biogeographical patterns and genetic structure were examined using statistical dispersal-vicariance analysis, Bayesian phylogenetic analysis, reduced median-joining haplotype network analysis, and discriminant analysis of principal components. The gene flow between related species was evaluated with an isolation-with-migration model. The ancestral range of the species of subsect. Macaronesicae was inferred to be Tenerife and the Cape Verde Islands, and Tenerife-La Gomera acted as sources of diversity to other islands of the Canary Islands. Inter-island colonization of E. lamarckii among the western islands and a colonization of E. regis-jubae from Gran Canaria to northern Africa were revealed. Both diversification between islands and radiation within islands have been revealed in the Euphorbia species (sect. Aphyllis subsect. Macaronesicae) of the Canary Islands. It was clear that this group began the speciation process in Tenerife-La Gomera, and this process occurred with gene flow between some related species.

  17. Fruit and seed morphology of Euphorbia aggr. Flavicoma. Taxonomic implications

    Directory of Open Access Journals (Sweden)

    Simon, Joan

    1992-12-01

    Full Text Available Capsule and seed morphology ofW. European species of Euphorbia aggr. flavicoma has been studied. A total of 1500 seeds coming from 13 taxa have been investigated under light microscope, scanning electron microscope and binocular stereoscope. Data were processed by multivariate analysis and the corresponding dendrogram is presented . At the end of the paper, a key is presented allowing to the separation of taxa down to the species level.

    S'estudia la morfologia de les càpsules i les granes de les espècies d' Euphorbia aggr. flavicoma a l'Europa Occidental. S'ha investigat un total de 1500 granes de 13 tàxons amb microscopi òptic, microscopi electrònic de rastreig i lupa bincular. Les dades han estat sotmeses a una anàlisi multivariant i es presenta el corresponent dendrograma. Al final del treball s'aporta una clau que permet distingir els tàxons a nivell d'espècie per mitjà de caràcters de la càpsula i de la grana.

  18. Use of biochar as peat substitute for growing substrates of Euphorbia × lomi potted plants

    Energy Technology Data Exchange (ETDEWEB)

    Dispenza, V.; Pasquale, C. de; Fascella, G.; Mammano, M.M.; Alonzo, G.

    2016-07-01

    Biochar from conifers wood was used in soilless culture as growing substrate alternative to peat for ornamental crops. Potted plants of Euphorbia × lomi Rauh cv. ‘Ilaria’ were grown with different mixtures (v:v) of brown peat and biochar in order to evaluate main physical and chemical characteristics of this biomaterial as well as its effect on plant growth, ornamental characteristics and nutrients uptake. Biochar addition to peat increased pH, EC and K content of the growing substrates, as well as air content and bulk density. Biochar content of substrates significantly affected plant growth and biomass partitioning: higher number of shoots and leaves, leaf area and leaf dry weight were recorded in plants grown in 40% peat-60% biochar, with respect to plants grown in 100% peat and secondarily in 100% biochar. Leaf chlorophyll content was higher in plants grown in 60% and 80% biochar, while biomass water use efficiency was higher with 60% biochar. Plant uptake of K and Ca increased as biochar content of the substrates increased. Hence, a growing substrate containing 40% brown peat and 60% conifers wood biochar was identified as the more suitable mixture allowing to have a high-quality production of Euphorbia × lomi potted plants.

  19. Euphorbia Species-derived Diterpenes and Coumarins as Multidrug Resistance Modulators in Human Colon Carcinoma Cells.

    Science.gov (United States)

    Wiśniewski, Jerzy; Wesołowska, Olga; Środa-Pomianek, Kamila; Paprocka, Maria; Bielawska-Pohl, Aleksandra; Krawczenko, Agnieszka; Duarte, Noelia; Ferreira, Maria-José U; Duś, Danuta; Michalak, Krystyna

    2016-05-01

    Recently, many new potent multidrug resistance (MDR) reversal agents have been discovered, among them lathyrane and jatrophane diterpenes isolated from various Euphorbia species. In the present study, the cytotoxicity, P-glycoprotein inhibition activity, and MDR reversal potency of six diterpenes and two coumarins from two Euphorbia species were studied in human colon carcinoma LoVo cells, and doxorubicin-resistant, LoVo/Dx cells. Cytotoxicity of the studied compounds (alone and in combination with doxorubicin) was investigated. Inhibition of P-glycoprotein transport activity was monitored by flow cytometry. Changes in intracellular doxorubicin accumulation were observed by means of fluorescence microscopy. Latilagascene B was demonstrated to be an effective P-glycoprotein inhibitor, able to increase doxorubicin accumulation in resistant cells, however not able to restore doxorubicin cytotoxicity in LoVo/Dx cells. The structure of latilagascene B seems to be an interesting candidate for further synthesis of new derivatives of reduced cytotoxicity and high anti-MDR potency. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  20. Kommunikative Konstitution von Organisationen

    DEFF Research Database (Denmark)

    Schoeneborn, Dennis; Wehmeier, Stefan

    2014-01-01

    Beiträge zur Unternehmenskommunikation behandeln in der Regel (strategisch) geplante interne oder externe Kommunikation. Der vorliegende Beitrag stellt einen alternativen Theorieansatz vor, der aktuell im nordamerikanischen Forschungsgebiet „Organizational Communication“ vorherrschend ist....... zunehmende Aufmerksamkeit erhält Der sogenannten „CCO-Perspektive“ („Communicative Constitution of Organizations“) zufolge bestehen Unternehmen aus einer Vielzahl von internen und externen Kommunikationspraktiken, die nur in bedingtem Maße strategisch steuerbar sind. Zugleich sind es eben diese...

  1. Kulturelle Aspekte von Textsorten

    Directory of Open Access Journals (Sweden)

    Siegfried Heusinger

    1998-12-01

    Full Text Available Ich fasse meine Überlegungen zu kulturellen Aspekten von Textsorten zusammen: 1. Mit unseren Kulturverständnis ist die terminologisierte Wortgruppe "interkulturelle Kommunikation" nicht zu begreifen als Kommunikation zwischen Menschen verschiedener kultureller Bindungen, sondern sie ist nicht zu begreifen als Kommunikation zwischen Menschen verschiedener kultureller Bindungen, sondern sie ist ethnisch wie auch ethisch angepasstes sprachlichkommunikatives Verhalten an kulturelle Traditionen der jeweils für den Kommunkations- akt vereinbarten Sprache. 2. Das Adjektiv "interkulturell" referiert auf idiomatisierte Wendungen im zwischenmenschlichen Kontakt wie auch auf kulturell gebundene Unterschiede in der Benennungsmotivation (z.B. anloben/österr./, vereidigen /dt./ 3. Das Adjektiv "interkulturell" ist ebenfalls zu beziehen auf den Austausch von Erfahrungen und Ideen, auf den Dialog von Kulturen. 4. Textsorten existieren in ihrer kulturellen in ihrer kulturellen Tradition, wobei das Kulturspezifische vornehmlich in traditionellen (aber entwicklungsoffenen Formulierungs- und Gestaltungsmustern zu suchen iost. Andere Textsortencharakteristika wie die situative Einbettung, die kommunikative Zwecksetzung, die thematische Bindung und die Komposition haben offenbar kaum eine kulturspezifische Prägung. 5. Im Trend zur Internationalisierung der Textsorten erweisen sich die kulturell geprägten Textmustervor allem zwischen angrenzenden Nationen häufig als affin.

  2. Nutzerorientiertes Management von materiellen und immateriellen Informationsobjekten

    OpenAIRE

    Hübsch, Chris

    2001-01-01

    Schaffung einer stabilen, erweiterbaren und skalierbaren Infrastruktur für die Bereitstellung von Diensten im Umfeld von Bibliotheken und ähnlichen wissensanbietenden Einrichtungen unter Verwendung von XML-RPC und Python.

  3. Comparative analysis of Solanum stoloniferum responses to probing by the green peach aphid Myzus persicae and the potato aphid Macrosiphum euphorbiae.

    Science.gov (United States)

    Alvarez, Adriana E; Broglia, Viviana G; Alberti D'Amato, Anahí M; Wouters, Doret; van der Vossen, Edwin; Garzo, Elisa; Tjallingii, W Fred; Dicke, Marcel; Vosman, Ben

    2013-04-01

    Plants protect themselves against aphid attacks by species-specific defense mechanisms. Previously, we have shown that Solanum stoloniferum Schlechtd has resistance factors to Myzus persicae Sulzer (Homoptera: Aphididae) at the epidermal/mesophyll level that are not effective against Macrosiphum euphorbiae Thomas (Homoptera: Aphididae). Here, we compare the nymphal mortality, the pre-reproductive development time, and the probing behavior of M. persicae and M. euphorbiae on S. stoloniferum and Solanum tuberosum L. Furthermore, we analyze the changes in gene expression in S. stoloniferum 96 hours post infestation by either aphid species. Although the M. euphorbiae probing behavior shows that aphids encounter more probing constrains on phloem activities-longer probing and salivation time- on S. stoloniferum than on S. tuberosum, the aphids succeeded in reaching a sustained ingestion of phloem sap on both plants. Probing by M. persicae on S. stoloniferum plants resulted in limited feeding only. Survival of M. euphorbiae and M. persicae was affected on young leaves, but not on senescent leaves of S. stoloniferum. Infestation by M. euphorbiae changed the expression of more genes than M. persicae did. At the systemic level both aphids elicited a weak response. Infestation of S. stoloniferum plants with a large number of M. persicae induced morphological changes in the leaves, leading to the development of pustules that were caused by disrupted vascular parenchyma and surrounding tissue. In contrast, an infestation by M. euphorbiae had no morphological effects. Both plant species can be regarded as good host for M. euphorbiae, whereas only S. tuberosum is a good host for M. persicae and S. stoloniferum is not. Infestation of S. stoloniferum by M. persicae or M. euphorbiae changed the expression of a set of plant genes specific for each of the aphids as well as a set of common genes. © 2012 The Authors Insect Science © 2012 Institute of Zoology, Chinese Academy of

  4. Unraveling the karyotype structure of the spurges Euphorbia hirta Linnaeus, 1753 and E. hyssopifolia Linnaeus, 1753 (Euphorbiaceae) using genome size estimation and heterochromatin differentiation

    Science.gov (United States)

    Santana, Karla C. B.; Pinangé, Diego S. B.; Vasconcelos, Santelmo; Oliveira, Ana R.; Brasileiro-Vidal, Ana C.; Alves, Marccus V.; Benko-Iseppon, Ana M.

    2016-01-01

    Abstract Euphorbia Linnaeus, 1753 (Euphorbiaceae) is one of the most diverse and complex genera among the angiosperms, showing a huge diversity in morphologic traits and ecologic patterns. In order to improve the knowledge of the karyotype organization of Euphorbia hirta (2n = 18) and Euphorbia hyssopifolia (2n = 12), cytogenetic studies were performed by means of conventional staining with Giemsa, genome size estimations with flow cytometry, heterochromatin differentiation with chromomycin A3 (CMA) and 4’,6-diamidino-2-phenylindole (DAPI) and Giemsa C-banding, fluorescent in situ hybridization (FISH) with 45S and 5S rDNA probes, and impregnation with silver nitrate (AgNO3). Our results revealed small metacentric chromosomes, CMA+/DAPI0 heterochromatin in the pericentromeric regions of all chromosomes and CMA+/DAPI− in the distal part of chromosome arms carriers of nucleolar organizing regions (NORs). The DNA content measurements revealed small genomes for both species: Euphorbia hirta with 2C = 0.77 pg and Euphorbia hyssopifolia with 2C = 1.41 pg. After FISH procedures, Euphorbia hirta, and Euphorbia hyssopifolia presented three and four pairs of terminal 45S rDNA sites, respectively, colocalizing with CMA+ heterochromatic blocks, besides only one interstitial pair of 5S rDNA signals. Additionally, the maximum number of active NORs agreed with the total number of observed 45S rDNA sites. This work represents the first analysis using FISH in the subfamily Euphorbioideae, revealing a significant number of chromosomal markers, which may be very helpful to understand evolutionary patterns among Euphorbia species. PMID:28123686

  5. Cytotoxicity of latex and pharmacobotanical study of leaves and stem of Euphorbia umbellata (Janaúba

    Directory of Open Access Journals (Sweden)

    Lívia E.C. Luz

    Full Text Available AbstractIn southern Brazil, the bottled latex of Synadenium grantii Hook f., Euphorbiaceae, is popularly used as a treatment of all types of cancer. Similarly, Synadenium umbellatum Pax. is used in the central western region of Brazil for the same purpose and in the same manner of use. Both plants are popularly known as janaúba or leitosinha. The objectives of this study were to use pharmacobotanical analysis to verify whether these two species, which are considered to be distinct, are actually the same to determine anatomical markers; to assist in the identification and differentiation of other Euphorbia; and to evaluate the cytotoxic activity of the latex in relation to HeLa and HRT-18 cells. Leaves and stems of the species were collected in Goiânia and Ponta Grossa and were investigated using scanning electron microscopy and optical microscopy techniques. The latex was also collected and analyzed in relation to its cytotoxic effect by employing MTT and NR techniques. The pharmacobotanical study of the specimens in both localities showed that they were the same species, namely Euphorbia umbellata (Pax Bruyns, which is the scientific nomenclature accepted and confirmed by an expert taxonomist who specializes in Euphorbia. The pharmacobotanical characteristics highlighted in this study can assist in the identification of the taxon and contribute to the control of the quality of this plant drug. The evaluation of the latex in relation to HRT-18 cells demonstrated action after 48 h of experiment. In contrast, in relation to HeLa cells its induced cytotoxicity in all times and a dose-dependent manner. The IC50 values (72 h observed were 252.58 ± 18.51 µg/ml and 263.42 ± 15.92 µg/ml to MTT experiment and 250.18 ± 19.48 µg/ml and 430.56 ± 19.71 µg/ml to NR experiment for the HeLa and HRT-18 cells, respectively.

  6. Soil surface searching and transport of Euphorbia characias seeds by ants

    Science.gov (United States)

    Espadaler, Xavier; Gómez, Crisanto

    The intensity of exploring the soil surface by ants was studied for the four species involved in the dispersal and predation of seeds of the West-Mediterranean myrmecochorous plant Euphorbia characias. During the dehiscence period (June) the whole soil surface is sccanned in 43 minutes. Not all ants that find a seed take it to the nest. For the four ant species studied ( Pheidole pallidula, Aphaenogaster senilis, Tapinoma nigerrimum, Messor barbarus) the proportion of ants that finally take the seed is 67.6%. In spite of this, the high level of soil surface searching explains the rather short time that seeds remain on the soil before being removed. The presence of an elaiosome is a key element in the outcome of the ant-seed interaction: a seed with elaiosome has a seven-fold increase in probability of being taken to the nest if found by a non-granivorous ant. The predator-avoidance hypothesis for myrmecochory is supported.

  7. Anti-inflammatory effect of Euphorbia supina extract in dextran sulfate sodium-induced colitis mice.

    Science.gov (United States)

    Cha, Ji-Yun; Jeon, Yong-Deok; Xin, Mingjie; Kim, Do-Kuk; Lee, Hoon-Yeon; Kim, Bo-Ram; Hwang, Sung-Woo; Kim, Dae-Ki; Jin, Jong-Sik; Lee, Young-Mi

    2017-11-01

    The aim of this study is to examine the anti-inflammatory effect of Euphorbia supina (ES) ethanol extract in dextran sulfate sodium (DSS)-induced experimental colitis model. ES was per orally administered at different doses of 4 or 20 mg/kg body weight with 5% DSS in drinking water for 7 days. Twenty mg/kg of ES administration regulated body weight decrease, recovered colon length shortening, and increased disease activity index score and myeloperoxidase level in DSS-induced colitis. Histological features showed that 20 mg/kg of ES administration suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Furthermore, ES suppressed the expressions of COX-2, iNOS, NF-kB, IkBα, pIkBα in colon tissue. These findings demonstrated a possible effect of amelioration of ulcerative colitis and could be clinically applied.

  8. Structural characterization of rubber from jackfruit and euphorbia as a model of natural rubber.

    Science.gov (United States)

    Mekkriengkrai, Dararat; Ute, Koiichi; Swiezewska, Ewa; Chojnacki, Tadeusz; Tanaka, Yasuyuki; Sakdapipanich, Jitladda T

    2004-01-01

    A structural study of low molecular weight rubbers from Jackfruit (Artocarpus heterophyllus) and Painted spurge (Euphorbia heterophylla) was carried out as model compounds of natural rubber from Hevea brasiliensis. The rubber content of latex from Jackfruit was 0.4-0.7%, which is very low compared with that of 30-35% in the latex from Hevea tree. The rubber from Jackfruit latex was low molecular weight with narrow unimodal molecular weight distribution (MWD), whereas that obtained from E. heterophylla showed very broad MWD. The 1H and 13C NMR analyses showed that Jackfruit rubber consists of a dimethylallyl group and two trans-isoprene units connected to a long sequence of cis-isoprene units. The alpha-terminal group of Jackfruit rubber was presumed to be composed of a phosphate group based on the presence of 1H NMR signal at 4.08 ppm corresponding to the terminal =CH-CH2OP group.

  9. Isoprenoid compounds from Euphorbia portlandica. X-ray structure of lupeportlandol, a new lupane triterpene

    Energy Technology Data Exchange (ETDEWEB)

    Madureira, Ana M.; Ferreira, Maria-Jose U. [Universidade de Lisboa, Lisboa (Portugal). Faculdade de Farmacia. Centro de Estudos de Ciencias Farmaceuticas]. E-mail: mjuferreira@ff.ul.pt; Duarte, Maria Teresa; Ascenso, Jose R. [Instituto Superior Tecnico, Lisboa (Portugal). Centro de Quimica Estrutural; Piedade, Maria Fatima M. [Universidade de Lisboa, Campo Grande, Lisboa (Portugal). Faculdade de Ciencias. Dept. de Quimica e Bioquimica

    2004-10-01

    Phytochemical survey of the Me{sub 2}CO extracts of the whole dried plant Euphorbia portlandica led to the isolation of a new pentacyclic triterpene alcohol, with the lupane skeleton, named lupeportlandol. Its structure was established as 3{alpha}-hydroxy-19{alpha}H-lup-20(29)-ene. The known pentacyclic triterpene glutinol and the steroid {beta}-sitostenone were also isolated. The characterization of the new compound and its acetylated derivative was based on spectroscopic methods and an X-ray diffraction analysis. Lupeportlandol acetate was inactive in cytotoxicity assays in vitro against three human tumor cell lines: MCF-7 (breast cancer), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer). (author)

  10. Characterization of Diterpenes from Euphorbia prolifera and Their Antifungal Activities against Phytopathogenic Fungi.

    Science.gov (United States)

    Xu, Jing; Kang, Jing; Cao, Xiangrong; Sun, Xiaocong; Yu, Shujing; Zhang, Xiao; Sun, Hongwei; Guo, Yuanqiang

    2015-07-01

    Euphorbia prolifera is a poisonous plant belonging to the Euphorbiaceae family. In this survey on plant secondary metabolites to obtain bioactive substances for the development of new antifungal agents for agriculture, the chemical constituents of the plant E. prolifera were investigated. This procedure led to the isolation of six new and two known diterpenes. Their structures, including absolute configurations, were elucidated on the basis of extensive NMR spectroscopic data analyses and time-dependent density functional theory ECD calculations. Biological screenings revealed that these diterpenes possessed antifungal activities against three phytopathogenic fungi. The results of the phytochemical investigation further revealed the chemical components of the poisonous plant E. prolifera, and biological screenings implied the extract or bioactive diterpenes from this plant may be regarded as candidate agents of antifungal agrochemicals for crop protection products.

  11. Antimicrobial Activity of Extracts from Leaves, Stems and Flowers of Euphorbia macroclada against plant pathogenic fungi

    Directory of Open Access Journals (Sweden)

    K. Al-Mughrabi

    2003-12-01

    Full Text Available Extracts drawn from dried and powdered flowers, stems and leaves of Euphorbia macroclada with some organic solvents were tested for antimicrobial effect against the fungi Verticillium dahliae, Fusarium oxysporum, Rhizopus stolonifer, Penicillium italicum, Rhizoctonia solani, Alternaria solani, Stemphylium solani, Cladosporium sp., Mucor sp., and Pythium sp. The strongest inhibitory effect of the extracts was observed against R. solani, V. dahliae, F. oxysporum, Pythium sp. and R. stolonifer. The weakest effect was against A. solani. Extracts from the stems had a stronger inhibitory effect than those from the flowers or leaves. Butanol was the best solvent to extract antimicrobial compounds from leaves, stems and flowers and was superior to chloroform, water and petroleum ether. Results clearly indicate that E. macroclada is a promising source of antimicrobial compounds.

  12. Host Plant Volatiles and the Sexual Reproduction of the Potato Aphid, Macrosiphum euphorbiae

    Directory of Open Access Journals (Sweden)

    Jessica Hurley

    2014-10-01

    Full Text Available In late summer, heteroecious aphids, such as the potato aphid, Macrosiphum euphorbiae, move from their secondary summer host plants to primary host plants, where the sexual oviparae mate and lay diapausing eggs. We tested the hypothesis that volatiles of the primary host, Rosa rugosa, would attract the gynoparae, the parthenogenetic alate morph that produce oviparae, as well as the alate males foraging for suitable mates. In wind tunnel assays, both gynoparae and males oriented towards and reached rose cuttings significantly more often than other odour sources, including potato, a major secondary host. The response of males was as high to rose cuttings alone as to potato with a calling virgin oviparous female. These findings are discussed within the seasonal ecology of host alternating aphids.

  13. An evolutionary perspective on drug discovery in the plant genus Euphorbia L. (Euphorbiaceae)

    DEFF Research Database (Denmark)

    Ernst, Madeleine

    Plants have been widely used in many traditional medical systems around the world and are still thesource of many modern drugs. However, the rate at which new plant-derived drugs are discoveredis slow and recent estimates of biodiversity loss, as well as the need for tackling global...... herbivory and physical stresses or to attract pollinators. Consequently, specializedmetabolites, as well as plants used in traditional medicine, are not randomly distributed across phylogenetictrees. Evolutionary approaches to plant-based drug discovery suggest that this informationcan be used to guide......-based drug discovery. Phylogenetic patterns in speciesused in traditional medicine were investigated, and it was found that species used medicinally are notrandomly distributed across the phylogenetic tree. Subsequently, Euphorbia chemical diversity andbioactivity were investigated using mass spectral...

  14. Anti-angiogenic activity of water extract from Euphorbia pekinensis Rupr.

    Science.gov (United States)

    Zhang, Wenting; Liu, Bin; Feng, Yaru; Liu, Jie; Ma, Zhiqiang; Zheng, Jian; Xia, Qing; Ni, Yuanyuan; Li, Farong; Lin, Ruichao

    2017-07-12

    Euphorbia pekinensis Rupr. (EP) is a Euphorbia species of Euphorbiaceae, which is widely used in traditional Chinese medicine. It has been reported to exhibit therapeutic effects on solid tumors, leukemias, and malignant ascites although underlying molecular mechanisms are poorly delineated. Anti-angiogenic therapy is a recognized strategy for treating cancer-based solid tumors, and is also associated with malignant ascites treatment. To study the anti-angiogenic properties of the water extract of EP vinegar preparation (WEVEP). Following WEVEP treatment, intersegmental blood vessels were assessed during the development of transgenic Tg (flk: mCherry) zebrafish as was the proliferation, migration and network formation of HUVECs in vitro. mRNA expression of specific angiogenic-related genes including VEGF family members, Met, and NRP2 was also measured using quantitative real-time PCR (Q-PCR). Data demonstrated that angiogenesis was inhibited by the WEVEP in zebrafish (from 100µg/mL to 250µg/mL, p numbers of administered groups were 26.00 ± 1.29 (100µg/mL), 24.54 ± 2.20 (150µg/mL), 22.66 ± 2.68 (200µg/mL), 20.80 ± 1.75 (250µg/mL), compared to 27.67 ± 0.96 of control group. Relative quantitative gene expression in zebrafish treated with WEVEP demonstrated that only VEGFR3 was significantly increased and other 23 genes including Met, VEGFA, Flt-1 were significantly decreased. WEVEP can positively modulate angiogenesis via multiple targeting mechanisms. Our novel results contribute towards the discovery of a possible mechanism(s) of the traditional use of EP in the treatment of cancer and malignant ascites. Copyright © 2017. Published by Elsevier B.V.

  15. Total phenolic compounds, antioxidant potential and α-glucosidase inhibition by Tunisian Euphorbia paralias L.

    Directory of Open Access Journals (Sweden)

    Malek Besbes Hlila

    2016-08-01

    Full Text Available Objective: To examine the potential antioxidant and anti-α-glucosidase inhibitory activities of Tunisian Euphorbia paralias L. leaves and stems extracts and their composition of total polyphenol and flavonoids. Methods: The different samples were tested for their antiradical activities by using 2, 2’- azinobis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS and 1,1-diphenyl-2-picrylhydrazyl (DPPH assays. In α-glucosidase activity, α-glucosidase (0.3 IU/mL and substrate, 2500 µmol/ L p-nitrophenyl α-D-glucopyranoside were used; absorbance was registered at 405 nm. Results: The leaves acetonic extract exhibited the strongest α-glucosidase inhibition [IC50 = (0.0035 ± 0.001 µg/mL], which was 20-fold more active than the standard product (acarbose [IC50 = (0.07 ± 0.01 µg/mL]. Acetonic extract of the leaves exhibited the highest quantity of total phenolic [(95.54 ± 0.04 µg gallic acid equivalent/mg] and flavonoid [(55.16 ± 0.25 µg quercetin equivalent/mg]. The obtained findings presented also that this extract was detected with best antioxidant capacity [IC50 = (0.015 ± 0.01 µg/mL] against DPPH and a value of IC50 equal to (0.02 ± 0.01 µg/mL against ABTS. Positive relationship between polyphenolic content of the tested Euphorbia paralias L. leaves and stems extracts and its antioxidant activity (DPPH and ABTS was detected. Elevated positive linear correlation was got between ABTS and total phenolic (R2 = 0.751. Conclusions: The findings clearly demonstrate that the use of a polar solvent enables extraction of significant quantities of phenol compounds and flavonoids.

  16. Crescimento e esporulação de Bipolaris euphorbiae cultivado sob diferentes condições nutricionais Growth and sporulation of Bipolaris euphorbiae cultivated under different nutritional conditions

    Directory of Open Access Journals (Sweden)

    Mara Cristina Penariol

    2008-10-01

    Full Text Available Apesar de ser considerado um potencial bioagente de controle do amendoim-bravo (Euphorbia heterophylla L. em cultivos de soja no Brasil, pouco se conhece sobre as características nutricionais do fungo Bipolaris euphorbiae Muchovej & Carvalho. O objetivo deste trabalho foi avaliar diferentes fontes de carbono (glicose, amido, sacarose, lactose e maltose, de nitrogênio (nitrato de sódio, nitrato de amônio, sulfato de amônio, fosfato de amônio dibásico, cloreto de amônio, de fósforo (fosfato de potássio monobásico, fosfato de potássio bibásico, fosfato de cálcio, fosfato de sódio, ácido fosfórico, fosfato de amônio e a suplementação do meio de cultivo com fontes orgânicas de macro e micronutrientes, para o crescimento e a esporulação de B. euphorbiae. O amido proporcionou o maior crescimento, sendo também considerada a fonte de carbono mais favorável para a esporulação. O melhor crescimento e esporulação de B. euphorbiae foram obtidos usando o nitrato de sódio como fonte de nitrogênio e fosfato de potássio monobásico e fosfato de cálcio como fonte de fósforo, embora as demais fontes de fósforo analisadas, exceto o ácido fosfórico, tenham igualmente favorecido a esporulação. A suplementação do meio de cultivo com peptona e extrato de levedura resultou em melhor crescimento e esporulação do fungo e a adição de vitaminas favoreceu a produção de conídios.Bipolaris euphorbiae Muchovej & Carvalho is considered a potential bioagent for control of selvage peanuts (Euphorbia heterophylla L. on soybean crops in Brazil. However, little is known about the nutritional characteristics of this fungus. The main objective of this research was to evaluate different sources of carbon (glucose, starch, sucrose, lactose and maltose, of nitrogen (sodium nitrate, ammonium nitrate, ammonium sulphate, bi-basic ammonium phosphate, ammonium chloride, of phosphorus (monobasic potassium phosphate, bi-basic potassium phosphate

  17. Lysozyme- and chitinase activity in latex bearing plants of genus Euphorbia--A contribution to plant defense mechanism.

    Science.gov (United States)

    Sytwala, Sonja; Günther, Florian; Melzig, Matthias F

    2015-10-01

    Occurrence of latices in plants is widespread, there are 40 families of plants characterized to establish lactiferous structures. Latices exhibit a constitutive part of plant defense due to the stickiness. The appearance of proteins incorporated in latices is well characterized, and hydrolytic active proteins are considerable. A lot of plants constitute so-called pathogenesis-related (PR) proteins, to overcome stressful conditions. In our investigation we are focused on latex bearing plants of Euphorbiaceae Juss., and investigated the appearance of chitinase- and lysozyme activity in particular. The present outcomes represent a comprehensive study, relating to the occurrence of lysozyme and chitinase activity of genus Euphorbia at the first time. 110 different species of genus Euphorbia L. were tested, and the appearance of chitinase and lysozyme were determined in different quantities. The appearance itself, and the physicochemical properties of latices indicate an efficient interaction for plant defense against pathogen attack. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  18. John von Neumann Birthday Centennial

    Energy Technology Data Exchange (ETDEWEB)

    Grcar, Joseph F.

    2004-11-12

    In celebration of John von Neumann's 100th birthday, a series of four lectures were presented on the evening of February 10, 2003 during the SIAM Conference on Computational Science and Engineering in San Diego. The venue was appropriate because von Neumann spent much of the later part of his life, in the 1950's, as an unofficial ambassador for computational science. He was then the only senior American scientist who had experience with the new computers (digital, electronic, and programmable) and a vision of their future importance. No doubt he would have relished the chance to attend a meeting such as this. The first speaker, William Aspray, described the ''interesting times'' during which computers were invented. His remarks were based on his history [1] of this period in von Neumann's life. We were honored to have John von Neumann's daughter, Marina von Neumann-Whitman, as our second speaker. Other accounts of von Neumann's life can be found in books by two of his colleagues [2] and [3]. Our third speaker, Peter Lax, provided both mathematical and international perspectives on John von Neumann's career. Finally, Pete Stewart spoke about von Neumann's numerical error analysis [4] in the context of later work; this talk did not lend itself to transcription, but readers may consult the historical notes in [5]. Our thanks to all the speakers for a remarkable evening. We are grateful to the DOE Applied Mathematical Sciences (AMS) program for partially supporting these lectures. Thanks are also due to SIAM and William Kolata, to our emcee, Gene Golub, to Paul Saylor for recording and editing, and to Barbara Lytle for the transcriptions. More about von Neumann's work can be learned from the recent American Mathematical Society proceedings [6].

  19. Spatio-temporal variation in seed production in three Euphorbia species and the role of animals on seed fate

    OpenAIRE

    Boieiro, Mário Rui Canelas

    2014-01-01

    Comparative studies on the reproductive biology of co-occurring related plant species have provided valuable information for the interpretation of ecological and evolutionary phenomena, with direct application in conservation management of plant populations. The aims of this thesis were to identify the causes of pre-dispersal reproductive losses in three Euphorbia species (the Mediterranean E. characias and the narrow endemics E. pedroi and E. welwitschii) and evaluate the variation ...

  20. Alejandro Von Humboldt

    Directory of Open Access Journals (Sweden)

    Gerardo Paz Otero

    1965-09-01

    Full Text Available Diverso fue y sigue siéndolo, el destino de los dos hermanos Humboldt, Guillermo y Alejandro. Sino que se inicia con el nacimiento: Guillermo, el mayor, nace el 22 de junio de 1767 en Potsdam, residencia de los emperadores prusianos, la ciudad de los palacios imperiales, el imperio del militarismo germano; su cuna se meció cerca al palacete de Sans-Soussi, donde Federico el Grande forja ba el poderío de Prusia, cultivaba las ciencias y las artes, anfitrionaba a los intelectuales de Europa, y era "vasallo espiritual de Volta ire", según la aguda frase de Goethe. Alejandro viene al mundo dos años después (14 de septiembre de 1769 en Berlín, en la casa burguesa de la Jagerstrasse (calle del cazador que su madre Elizabeth von Humboldt heredara de su primer esposo.

  1. Der Einfluss von Phlorizin auf den programmierten Zelltod von Erythrozyten

    OpenAIRE

    Meier, Anja Doris

    2013-01-01

    Erythrozyten sind in der Lage, suizidalen Zelltod zu betreiben. Von einigen Substanzen ist bereits bekannt, dass sie die sogenannte Eryptose beeinflussen. Beispiele dafür sind Quecksilber, Monensin, Benzethonium und Oridonin, welche zu den Stimulatoren der Eryptose gehören. Blebbistatin, Koffein und Endothelin, gehören zu den Inhibitoren. In dieser Studie sollte untersucht werden, welchen Einfluss Phlorizin auf den Ablauf des suizidalen Zelltodes von Erythrozyten hat. Es wurde belegt, dass si...

  2. Acute Toxicity Of Euphorbia Royleana Boiss (Euphorbiaceae latex on freshwater catfish, Heteropneustes Fossilis (Siluriformes, Heteropneustidae Toxicidad aguda del látex de Euphorbia royleana Boiss (Euphorbiaceae en el bagre de agua dulce, Heteropneutes fossilis (Siluriformes, Heteropneustidae

    Directory of Open Access Journals (Sweden)

    Prasad ManiRam

    2010-06-01

    Full Text Available An acute toxicity test was performed by using a four-day static renewal test to determine the LC50 value of aqueous extract of Euphorbia royleana latex for the freshwater fsh, Heteropneustes fossilis. The LC50 values, their upper and lower confdence limits and slope functions were calculated. The LC50 values for aqueous extract of Euphorbia royleana latex at various exposure periods were 7.758 mg/L for 24 h, 5.847 mg/L for 48 h, 4.474 mg/L for 72 h and 3.090 mg/L for 96 h. The regression coeffcient showed that there was signifcant negative correlation between exposure time and different LC values. Hence, it is concluded that the concentration to produce toxicity of latex of Euphorbia royleana is comparable and close to the concentration to produce toxicity of synthetic organophosphates pesticides for the fsh H. fossilis. Therefore, adequate precautions must be taken when Euphorbia royleana latex is being used near fsh- inhabited areas.La prueba de la toxicidad aguda fue realizada utilizando un test estático con renovación, de cuatro días de duración, para determinar el valor de la CL50 de un extracto acuoso del látex de Euphorbia royleana, en el pez de agua dulce Heteropneustes fossilis. Se calcularon el valor de la CL50, los límites de confanza máximo y mínimo y la pendiente. Los valores de la CL50 para el extracto acuoso del látex en varios períodos de exposición fueron 7,758 mg/L para 24 h, 5,847 mg/L para 48 h, 4,474 mg/L para 72 h y 3,090 mg/L para 96 h. El coefciente de regresión mostró una correlación negativa signifcativa entre el tiempo de exposición y diferentes valores de la CL50. Se concluye que la concentración del látex de E. royleana que produce toxicidad es comparable y cercana a la de los plaguicidas sintéticos organofosforados para el pez H. fossilis. Por lo tanto, se deben tomar precauciones adecuadas cuando el látex de E. royleana es utilizado cerca de áreas donde habita el pez H. fossilis.

  3. Einsatz von Nickel-Katalysatoren zum Cracken von Teerprodukten aus der Niederdruckaufkohlung von Stahl mit Ethin

    OpenAIRE

    Mbadinga Mouanda, Gelase

    2009-01-01

    Die Niederdruckaufkohlung von Stahl ist ein modernes Verfahren, das zur Einsatzhärtung von Stahlbauteilen dient. Bei Temperaturen zwischen 900 und 1050 °C und Drücken unter 50 mbar werden Bauteile durch heterogene Pyrolyse von Ethin in einem Ofen einsatzgehärtet. Das während der Pyrolyse erzeugte Abgas enthält aromatische Kohlenwasserstoffe und kann katalytisch behandelt werden. Der Katalysator wird durch Rußablagerung desaktiviert und muss zyklisch durch Verbrennung mit Luft regeneriert werd...

  4. Living with von Willebrand Disease

    Science.gov (United States)

    ... the condition. For example, the school nurse, teacher, daycare provider, coach, or any leader of afterschool activities ... MedlinePlus) Von Willebrand Disease (MedlinePlus) Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting ...

  5. Ueber einige Coelenterata von Australien

    NARCIS (Netherlands)

    Stiasny, G.

    1931-01-01

    I. Hydromedusen. *Olindias singularis Browne. II. Scyphomedusen. *Atolla wyvillei Haeckel. *Linuche unguiculata O. Swartz. Pelagia noctiluca Péron u. Lesueur. Cyanea capillata var. annaskala von Lendenfeld. Netrostoma coerulescens Maas. *Versura anadyomene (Maas) Mayer. Catostylus mosaicus L.

  6. Kleben von Kunststoff mit Metall

    CERN Document Server

    Brockmann, W; Käufer, H

    1989-01-01

    Das Buch behandelt das Kleben von Kunststoffen mit Metallen in einer fur den Praktiker verstandlichen und umsetzbaren Form. Es leitet zu Klebeverfahren an, die optimale Ergebnisse hinsichtlich Qualitat, Dauerhaftigkeit und Wirtschaftlichkeit liefern.

  7. Fluorido-Komplexe von Technetium

    OpenAIRE

    Mariappan Balasekaran, Samundeeswari

    2013-01-01

    Zusammenfassung Diese Dissertationsschrift befasst sich mit der Synthese und Charakterisierung neuer Technetiumfluoride mit dem Metall in den Oxidationsstufen “+1”, “+2”, “+4” und “+6”. Im ersten Kapitel wird über die Isolierung von unterschiedlichen Salzen von Fluoridonitridotechnetaten(VI) entweder aus Nitridotechnetium(VI)-säure oder aus Pertechnetat durch den Einsatz geeigneter Reduktionsmittel berichtet. Das Cäsiumsalz dieser Verbindung bildet einen oxido-verbrückten, dimeren Kompl...

  8. Effiziente chemoenzymatische Synthese von dhydroartemisinaldehyd

    OpenAIRE

    Demiray, Melodi; Tang, Xiaoping; Wirth, Thomas; Faraldos, Juan A.; Allemann, Rudolf K.

    2017-01-01

    Artemisinin aus der Pflanze Artemisia annua ist das wirkungsvollste Arzneimittel zur Behandlung von Malaria. Die Sesquiterpen-Cyclase Amorphadien-Synthase, ein Cytochrom-abhängiges CYP450 und eine Aldehyd-Reduktase wandeln in der Pflanze Farnesyl-Diphosphat (FDP) in Dihydroartemisinaldehyd (DHAAl) um, welches ein Schlüsselzwischenprodukt in der Biosynthese von Artemisinin und eine halbsynthetische Vorstufe in der chemischen Synthese des Arzneimittels ist. Hier berichten wir über einen chemoen...

  9. Physiotypic Plasticity and Survival of Arido-active Euphorbia triaculeata (Euphorbiaceae in its Natural Habitat

    Directory of Open Access Journals (Sweden)

    Turki A. Al-Turki

    2014-12-01

    Full Text Available Leafless stem succulent Euphorbia triaculeata Forssk. is abundant in arid regions southwest of the Arabian Peninsula. These regions are characterized by short wet season with erratic rainfall and long dry season with high temperature and high irradiance. Field observations indicated that the plant survives the long dry season and acquires a red stem colour under high irradiance and protracted drought. Our work aimed at investigating survival of this arido-active species in its natural habitat by studying diurnal and seasonal changes in stomatal conductance, cell sap acidity, and chlorophyll fluorescence. Results showed that E. triaculeata is obligate crassulacean acid metabolism (CAM plant. Under protracted drought, low stomatal conductance and dampening of CAM denoted a shift to CAM-idling. Observed stress-induced reduction of Photosystem II activity occurred in concomitance with increased non-photochemical quenching of chlorophyll fluorescence and increased anthocyanin content. These results reflected operation of a photoprotective mechanism involving interplay of non-photochemical energy dissipation via xanthophyll cycle and alleviation of oxidative stress by anthocyanin. It was concluded that E. triaculeata survives in its arid habitat by performing obligate CAM, shifting to CAM-idling under protracted drought, increasing non-photochemical excess energy dissipation, and accumulating anthocyanin pigment for its antioxidant attributes.

  10. Antioxidant activity and concentration of secondary metabolites in the plant parts of Euphorbia cyparissias L.

    Directory of Open Access Journals (Sweden)

    Stanković Milan S.

    2014-01-01

    Full Text Available This paper presents the results of a screening of nine different extracts from the plant parts (leaves, flowers and stems of Euphorbia cyparissias for total phenolic content, concentration of flavonoids and in vitro antioxidant activity. Main reason for this study is the determination of these parameters and their variability among plant parts and plant extracts obtained by different solvents, respectively. Obtained amounts for total phenolic content ranged from 10.76 to 40.72 mg GA/g. The concentration of flavonoids varied from 34.32 to 134.34 mg Ru/g. The IC50 values of antioxidant activity varied from 88.48 to 2891.08 μg/ml. Results obtained from the different plant parts were of uneven value. Great variability of the studied parameters was observed when comparing the effectiveness of the used solvents. The acetone extracts from stems contain the greatest concentrations of phenolic compounds, especially flavonoids, and showed high antioxidant activity. According to our research, plant parts from E. cyparissias can be regarded as promising candidates for natural plant sources with high value of biological compounds.

  11. Molluscicidal effect of Euphorbia umbellata (Pax Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail

    Directory of Open Access Journals (Sweden)

    Luciana Patrícia Lima Alves Pereira

    2017-12-01

    Full Text Available ABSTRACT Euphorbia umbellata (Pax Bruyns is an easily cultivated shrub, with occurrence in the tropical regions of the American and African continents. Chemical studies have revealed that the latex of this plant is rich in terpene compounds, which are highly toxic to snails Biomphalaria glabrata (Basommatophora: Planorbidae. The aim of this study was to evaluate the chemical composition and molluscicidal activity of the latex produced by E. umbellata, as well as the safety of its application in aquatic environments. The concentration of latex that killed 90% of the exposed snails after 24 h exposure (LC90 was 3.69 mg/L. Toxicity bioassays using Danio rerio (zebrafish revealed that these animals were less susceptible to latex than planorbids. However, it is important to perform other toxicity tests to ensure the feasibility of using latex to control populations of mollusks that contribute to schistosomiasis transmission. A phytochemical screening performed with the E. umbellata latex identified the triterpenoid and coumarin class. Further studies are warranted to isolate, identify, and test the active compounds of E. umbellata latex in B. glabrata.

  12. Phyto toxic effects of Euphorbia dracunculoides: a weed of rainfed chickpea-chickpea cropping system

    Energy Technology Data Exchange (ETDEWEB)

    Shance, S.; Tranveer, A.; Javaid, M. M.; Chaudhry, K. M.; Aziz, A.; Khaliq, A.; Chaudhry, M. N.; Pervez, M. A.; Awan, I. U.

    2011-07-01

    Phyto toxic effect occurs when plants release chemicals that inhibit neighbouring plants. Phyto toxic effects of aqueous extracts of different parts of Euphorbia dracunculoides L. (green spurge) at two concentrations, and its infested soil were investigated on germination and seedling growth of chickpea (Cicer arietinum L.). The fruit extract at 1:20 (w/v) concentration caused maximum reduction (12%) in germination of chickpea seeds while leaf extract at 1:10 (w/v) concentration resulted in maximum mean germination time value and minimum germination index of chickpea seeds. All the traits of chickpea seedling growth including emergence were adversely affected by the aqueous extracts at both concentrations. Further, the inhibition of chickpea seedling growth was more pronounced with 1:10 (w/v) concentration whereas the lower concentration (1:20 w/v) showed stimulatory effect on shoot length, seedling vigor index and chlorophyll contents of chickpea seedlings. The leaf extract at 1:10 (w/v) concentration proved most harmful to seedling growth and chlorophyll contents (76% reduction) of chickpea. Soil beneath the E. dracunculoides plants significantly reduced emergence (23%), seedling vigor index (55%) and chlorophyll content (19%) of chickpea but a significant increase in N (6%), P (16%) and K (4%) contents of chickpea seedlings was recorded. Thus it can be concluded that E. dracunculoides contains compounds in its tissues which may cause phyto toxic effects on chickpea under field conditions. (Author) 31 refs.

  13. Evaluation of hydrocarbon plants suitable for cultivation in Florida. [Euphorbia tirucalli, E. lathyris, and Asclepias curassavica

    Energy Technology Data Exchange (ETDEWEB)

    Dehgan, B.; Wang, S.C.

    1983-01-01

    Most of the hydrocarbon plants reported in the literature are not suitable for cultivation under Florida conditions. Preliminary results of field and greenhouse trials have indicated two species; Euphorbia tirucalli, which is suitable only for south Florida and Asclepias curassavica which has shown promise for the entire state. The hydrocarbon content of E. tirucalli increases with age of the plants (8.19-11.90%), whereas, that of A. curassavica is influenced positively by fertilization (3.62%) and negatively by supplemental irrigation (2.75%). A comparison between the results of field trials with A. curassavica in Florida and E. lathyris in California shows similar biomass yields under unirrigated conditions, despite 3.6 to 7.8 times greater nitrogen application for E. lathyris. Because of environmental conditions in Florida, E. lathyris is not capable of good growth. It is suggested that future research on hydrocarbon plants should concentrate on selection of individuals or species with vigorous, upright growth habits, low fertilizer-irrigation requirements and high hydrocarbon contents. 18 references.

  14. Contribuição para o estudo da Euphorbia brasiliensis Lam

    Directory of Open Access Journals (Sweden)

    R. J. de Siqueira-Jaccoud

    1956-06-01

    Full Text Available O autor, após tecer rápidas considerações sôbre Phytomonas da planta em questão e do gênero Manihot, passa a dar: métodos por êle empregados na confecção da presente nota; sucinta descrição da Euphorbia brasiliensis Lam. e suas variedades; nomes vulgares por que é a mesma conhecida no Brasil; resultado negativo, por êle encontrado, nas pesquisas de alcalóide e, finalmente, descrição anatômica da fôlha e caule. Fôlha. a - limbo: epidermes com cutícula e estoma, uma camada de células paliçadicas, tecido lacunoso, ramificações dos tubos laticiferos e bainha dos feixes bem desenvolvida. b - nervura principal: epidermes com cutícula, uma camada de tecido paliçadico, bainha dos feixes em semicírculo, xilema, floema e parênquima. Caule - Epiderme com cutícula, colênquima, parênquima cortical, tubos laticíferos, esclerócitos, floema, câmbio e fibras do lenho (inclusive gelatinosas, vasos e, finalmente, parênquima fundamental.

  15. Euphorbia neriifolia L.: Review on botany, ethnomedicinal uses, phytochemistry and biological activities.

    Science.gov (United States)

    Mali, Prashant Y; Panchal, Shital S

    2017-05-01

    The present review is intended to provide information on botany, ethnomedicinal uses, phytochemistry and biological activities of various parts of Euphorbia neriifolia (E. neriifolia). E. neriifolia has several ethnomedicinal uses. The latex of E. neriifolia is used as laxative, purgative, rubefacient, carminative and expectorant as well as in treatment of whooping cough, gonorrhoea, leprosy, asthma, dyspepsia, jaundice, enlargement of the spleen, tumours, stone in the bladder, abdominal troubles and leucoderma. Leaves are brittle, heating, carminative, and good for improving the appetite and treatment of tumours, pains, inflammations, abdominal swellings and bronchial infections. Roots are used as symptomatic treatment of snake bite, scorpion sting and antispasmodic. Various plant parts or whole E. neriifolia extract and its isolates have been reported scientifically using various in-vivo and in-vitro experimental methods for anaesthetic, analgesic, anti-anxiety, anti-convulsant, anti-psychotic, anti-arthritis, anti-carcinogenic, antidiabetic, anti-diarrhoeal, anti-inflammatory, anti-thrombotic, antimicrobial, antioxidant, antiulcer, cytotoxic, death-receptor expression enhancing, dermal irritation, diuretic, haemolytic, immunomodulatory, radioprotective, scorpion venom and wound healing properties. It is reported to have chemical constituents like, neriifolin-S, neriifolin, neriifoliene, euphol, neriifolione, cycloartenol, nerifoliol, lectin, euphonerins A-G, 3-O-acetyl-8-O-tigloylingol, taraxerol, antiquorin, etc. Identified chemical constituents are still required to be explored for their advanced isolation techniques and biological activities. Copyright © 2017 Hainan Medical University. Production and hosting by Elsevier B.V. All rights reserved.

  16. Resistence of Euphorbia Heterophylla L. to ALS-inhibiting herbicides in soybean Resistência de Euphorbia Heterophylla L. aos herbicidas inibidores da ALS na cultura da soja

    Directory of Open Access Journals (Sweden)

    Gerson Augusto Gelmini

    2005-10-01

    Full Text Available Herbicides are widely used in soybean for weed control, and the selection pressure attributed to the repeated use of herbicides with similar modes of action on the same site has caused selection for resistant biotypes within and among previously susceptible species, such as Euphorbia heterophylla L., in relation to ALS enzyme inhibitors, in the states of Paraná, Rio Grande do Sul, and São Paulo, Brazil. Seeds of E. heterophylla were collected to examine possible new cases of resistant populations and to test alternative herbicide treatments to manage these populations, in the Caarapó region, State of Mato Grosso do Sul, Brazil, in areas where plants of this species have survived continuous herbicide applications. The experiment was carried out under greenhouse conditions, where biotypes with a history of suspected resistance were compared with a known susceptible biotype. Several post-emergence herbicides were sprayed at zero, one, two, four, and eight times the recommended field application rates. Twenty days after application, plants were harvested, and control percentage and fresh weight were determined to establish dose-response curves, in the aim to obtain the resistance factor using CD50 and RD50 data. The chlorimuron-ethyl resistance factor values for the control percentage and fresh weight parameters were higher than 16.5 and 16.9, respectively, while imazethapyr showed resistance factors higher than 25.0 and 23.5, respectively. The resistant biotype showed different resistance levels to chlorimuron-ethyl and imazethapyr, showing cross-resistance to the sulfonylurea and imidazolinone groups. Nevertheless, this biotype was effectively controlled by fomesafen (250 g ha-1, lactofen (120 g ha-1, flumiclorac-pentyl (40 g ha-1, glufosinate-ammonium (150 g ha-1, and glyphosate (360 g ha-1.Os herbicidas constituem a principal medida de controle de plantas daninhas na cultura da soja, mas através da pressão de seleção, o uso contínuo e

  17. Die Wertigkeit von Bildinformationskategorien und ihre Rolle bei der Beurteilung von Bildern als Medien

    OpenAIRE

    Wieczorek, Ulrich

    1997-01-01

    Die Wertigkeit von Bildinformationskategorien und ihre Rolle bei der Beurteilung von Bildern als Medien. - In: Die Geographiedidaktik ist tot, es lebe die Geographiedidaktik : Festschr. zur Emeritierung von Josef Birkenhauer / hrsg. von Friedhelm Frank ... - München, 1997. - S. 253-271. - (Münchner Studien zur Didaktik der Geographie ; 8)

  18. Ethnographische Filme und die Darstellung von Frauen

    Directory of Open Access Journals (Sweden)

    Judith Keilbach

    2002-03-01

    Full Text Available In dieser Filmographie werden ethnographische und koloniale Filme aus dem Bestand des Nederlands Filmmuseum kommentiert, die für die Frage nach der Darstellung von Frauen und Geschlechterverhältnissen von Interesse sind.

  19. John von Neumann selected letters

    CERN Document Server

    2005-01-01

    John von Neuman was perhaps the most influential mathematician of the twentieth century, especially if his broad influence outside mathematics is included. Not only did he contribute to almost all branches of mathematics and created new fields, but he also changed post-World War II history with his work on the design of computers and with being a sought-after technical advisor to many figures in the U.S. military-political establishment in the 1940s and 1950s. The present volume is the first substantial collection of (previously mainly unpublished) letters written by von Neumann to colleagues, friends, government officials, and others. The letters give us a glimpse of the thinking of John von Neumann about mathematics, physics, computer science, science management, education, consulting, politics, and war. Readers of quite diverse backgrounds will find much of interest in this fascinating first-hand look at one of the towering figures of twentieth century science.

  20. An Invitation from Lars von Trier

    DEFF Research Database (Denmark)

    Skadhauge, Troels; Tønder, Lars

    2015-01-01

    Translation of Martin Krasnik interview with Lars von Trier broadcast on DR2, January 12, 2015. The following is an interview of Lars von Trier (LvT) by the Danish journalist Martin Krasnik (MK). The interview took place in Lars von Trier’s home in Brede, a small town just outside Copenhagen...

  1. Management von Anforderungsdokumenten mittels semantischer Wikis

    OpenAIRE

    Decker, B.

    2005-01-01

    Im Projekt RISE wird untersucht, wie durch den Einsatz von Wikis das Anforderungsmanagement von Software Projekten agil unterstützt werden kann. Um das oftmals chaotische Wachstum von Inhalten in den Griff zu bekommen, werden maschinelle Lernverfahren genutzt, um Inhalte zu strukturieren und dem Benutzer zugänglich zum machen.

  2. Multivariat-statistische Auswertung von energiedispersiven Röntgenfluoreszenzspektren zur Identifizierung von Substanzen

    OpenAIRE

    Kessler, Thorsten

    2001-01-01

    Es wurde der Einsatz von multivariater Auswertung von energiedispersiven Röntgenfluoreszenzanalyse (EDRFA) -Spektren für die Zuordnung von Substanzen getestet. Hierbei erfolgten u. a. Untersuchungen zur Zuordnungsanalytik von Chemikalien ohne und mit Verpackungen. Zur Untersuchung von Chemikalien mit Verpackung wurden ausschließlich anorganische, feste Chemikalien in z.T. unterschiedlicher Verpackung herangezogen. Zusätzlich sollte ein Vergleich zwischen Messungen durch gleiche Verpackungen u...

  3. Potato aphid Macrosiphum euphorbiae performance is determined by aphid genotype and not mycorrhizal fungi or water availability.

    Science.gov (United States)

    Karley, Alison Jane; Emslie-Smith, Matthew; Bennett, Alison Elizabeth

    2017-12-01

    Intra- and interspecific variation in plant and insect traits can alter the strength and direction of insect-plant interactions, with outcomes modified by soil biotic and abiotic conditions. We used the potato aphid (Macrosiphum euphorbiae Thomas) feeding on cultivated Solanum tuberosum and wild Solanum berthaulti to study the impact of water availability and plant mutualistic arbuscular mycorrhizal (AM) fungi on aphid performance and susceptibility to a parasitoid wasp (Aphidius ervi Haliday). Plants were grown under glass with live or sterile AM fungal spores and supplied with sufficient or reduced water supply. Plants were infested with 1 of 3 genotypes of M. euphorbiae or maintained as aphid-free controls; aphid abundance was scored after 1 week, after which aphid susceptibility to A. ervi was assayed ex planta. Solanum tuberosum accumulated c. 20% more dry mass than S. berthaultii, and root mass of S. berthaultii was smallest under reduced water supply in the presence of AM fungi. Aphid abundance was lowest on S. berthaultii and highest for genotype "2" aphids; genotype "1" aphid density was particularly reduced on S. berthaultii. Aphid genotype "1" exhibited low susceptibility to parasitism and was attacked less frequently than the other two more susceptible aphid genotypes. Neither AM fungi nor water availability affected insect performance. Our study suggests a fitness trade-off in M. euphorbiae between parasitism resistance and aphid performance on poor quality Solanum hosts that warrants further exploration, and indicates the importance of accounting for genotype identity in determining the outcome of multitrophic interactions. © 2017 Institute of Zoology, Chinese Academy of Sciences.

  4. Homopteren von Java, gesammelt von Herrn Edw. Jacobson

    NARCIS (Netherlands)

    Melichar, L.

    1914-01-01

    Herr Edw. Jacobson hat auf Java in den Jahren 1908— 1910 Homopteren gesammelt und mir die Bearbeitung des gesammelten Materiales übertragen. Die Jacobson’sche Ausbeute ist insoferne bemerkenswert, als dieselbe viele Mikrohomopteren enthält, welche von nichtfachkundigen Sammlern gewöhnlich nicht

  5. The candelabra tree (Euphorbia ingens: a source of water for black rhinoceros in Liwonde National Park, Malawi

    Directory of Open Access Journals (Sweden)

    C.O. Dudley

    1997-01-01

    Full Text Available The introduction of two rhinoceros into a 15 km2 fenced sanctuary within Liwonde National Park provided an opportunity for close observation of the animals feeding on the toxic succulent Euphorbia ingens. Feeding invariably caused the death of the plant and for plants with basal diameters between 5-17 cm, mortality ranged from 40-90 . During the severe drought of 1994 rhinoceros did not drink from the artificial waterhole from approximately 15 July to at least 23 September. As this waterhole was the only source of free water it is believed that the rhinoceros obtained their water from browsing on E. ingens.

  6. Constituents of euphorbiaceae 12. Comm. (1). Isolation and structure elucidation of four new cerebrosides from Euphorbia biglandulosa Desf.

    Science.gov (United States)

    Falsone, G; Cateni, F; Visintin, G; Lucchini, V; Wagner, H; Seligmann, O

    1994-03-01

    Four new cerebrosides 4-6 were isolated from the latex of Euphorbia biglandulosa Desf. and their structures determined. Normal and reverse-phase flash chromatography was effective for the isolation of the cerebrosides, and FAB-MS spectrometry, 1H-NMR, 13C-NMR, DQF-COSY and HMQC experiments and chemical reactions were useful in elucidating their structure. EI-MS of the dimethyl disulfide derivatives of the long chain bases and glucosphingoside-heptaacetates was decisive for the determination of the double bond position on the long chain parts.

  7. (19αH)-lupane and (9βH)-lanostane triterpenes from Euphorbia helioscopia trigger apoptosis of tumor cell.

    Science.gov (United States)

    Li, Jun; Wang, Wen-Qiong; Song, Wei-Bin; Xuan, Li-Jiang

    2018-03-01

    Chemical investigation of Euphorbia helioscopia resulted in the identification of seven new triterpenes named euphorbatrine A-G (1-7), including two (19αH)-lupane (1-2) and three (9βH)-lanostane (4-6), which are very rare metabolites from plants. Their structures were elucidated by extensive spectroscopic analysis, X-ray crystallography and chemical methods. Compounds 5 and 6 triggered apoptosis of Hela -/- cell with EC 50 values of 1.59±0.25 and 26.48±0.78μM, respectively. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Inhibition of α-glucosidase by new prenylated flavonoids from euphorbia hirta L. herb.

    Science.gov (United States)

    Sheliya, Manjur Ali; Rayhana, Begum; Ali, Abuzer; Pillai, Krishna Kollapa; Aeri, Vidhu; Sharma, Manju; Mir, Showkat R

    2015-12-24

    Euphorbia hirta L. (Euphorbiaceae) is a pantropical medicinal rhizomatous herb, traditionally used in the treatment of diabetes, respiratory and gastro-intestinal disorders. To isolate and characterize the constituents of Euphorbia hirta and evaluate their in-vitro α-glucosidase inhibitory activity. The study is also aimed at describing structural activity relationship, type of α-glucosidase inhibition and in-vivo potential to regulate post prandial hyperglycemia in Wistar rats. Methanolic extract of whole plant was suspended in water, and sequentially fractionated with n-hexane and ethyl acetate. Further ethyl acetate fraction was subjected to medium pressure liquid chromatography (MPLC) to isolate the active molecules under the following experimental conditions, pressure (up to 5 kg/cm(2)) and flow rate (2 in./min). The structural elucidation of isolated compounds was done on the basis of detailed spectral analysis. The α-glucosidase inhibitory potential of isolated compounds was evaluated and compared with standard drug acarbose. In addition, type of inhibition was dwelled by Lineweaver-Burk plot analysis. Further, sucrose tolerance test was performed in Wistar rats pre-treated with the isolated compounds and acarbose (0.015 mM) followed by a sucrose load (2g/kg, p.o.) and blood glucose level was measured up to 120 min by the glucose oxidase method. The ethyl acetate fraction afforded quercetrin (1), dimethoxy quercetrin (2), along with two new prenylated flavonosides designated as hirtacoumaroflavonoside (3) and hirtaflavonoside-B (4) characterized as 7-O-(p-coumaroyl)-5,7,4'-trihydroxy-6-(3,3-dimethyl allyl)-flavonol-3-O-β-D-glucopyranosyl-(2" → 1"')-O-α-L-rhamnopyranoside and 5, 7, 3', 4'-trihydroxy-6-(3, 3-dimethyl allyl)-8-(iso-butenyl)-flavonol-3-C-β-d-glucopyranoside, respectively. All the isolated compounds showed dose dependent inhibition of α-glucosidase which was found to be comparable to acarbose. Maximum α-glucosidase inhibition was

  9. Replikation von µ-Peptidarrays

    OpenAIRE

    Striffler, Jakob

    2014-01-01

    In der vorliegen Arbeit wurde ein Verfahren erarbeitet und mit Photometrie, XPS und ToF-SIMS charakterisiert, mit dem durch mikropartikelbasierte Verfahren hergestellte µ-Peptidarrays von Syntheseoberflächen abgespalten und auf beliebige Zieloberflächen transferiert werden können.

  10. Von Krahl ON! / Terje Metsavas

    Index Scriptorium Estoniae

    Metsavas, Terje

    2008-01-01

    Madli Pesti ja Terje Metsavas kohtusid Von Krahli teatri tehnilise meeskonnaga teatri black-box-saalis. Teatri tehniline meeskond on tehnikadirektor Enar Tarmo, video- ja multimeediaga tegelev Lauri Sepp, tehnikud Janno "John" Jaanus, Oliver Kulpsoo ja Allan Räim. Selles, kuidas sünnivad "tehnikaimed" ja kuidas lahendatakse lavastuslikke projekte

  11. Integration von Produktion und Instandhaltung

    OpenAIRE

    Hans-Böckler-Stiftung

    2003-01-01

    Die Faktoren Produktqualität und Kosten-Nutzen-Verhältnis sind entscheidend im Wettbewerb. Um diese Faktoren zu optimieren, suchen die Unternehmen nach innovativen Modellen der Integration von Produktion und Instandhaltung. Über Konzeption und Erprobung solcher Modelle berichtet eine Arbeitsgruppe der Engeren Mitarbeiter der Arbeitsdirektoren Stahl Fachausschuss 1/00.

  12. Antioxidant and Cytotoxic Activities and Phytochemical Analysis of Euphorbia wallichii Root Extract and its Fractions.

    Science.gov (United States)

    Ul-Haq, Ihsan; Ullah, Nazif; Bibi, Gulnaz; Kanwal, Simab; Sheeraz Ahmad, Muhammad; Mirza, Bushra

    2012-01-01

    Euphorbia wallichii a perennial herb growing mainly in Himalayas has been widely used in folk medicines for its medicinal properties. In the present study, the crude methanolic root extract (CME) and its fractions; n-Hexane Fraction (NHF), n-Butanol Fraction (NBF), Chloroform Fraction (CHF), Ethyl acetate Fraction (EAF) and Aqueous Fraction (AQF) of this plant specie were investigated for antioxidant and cytotoxic activities and phytochemical analysis. Antioxidant activity was determined by using 2,2-diphenyl-1-picryl-hydrazyl free radical (DPPH) and DNA protection assay performed on pBR322 plasmid DNA. In both these assays, promising results were obtained for CME as well as other fractions. The IC50 values for DPPH assay were in a range of 7.89 to 63.35 μg/ml in which EAF showed the best anti-oxidant potential and almost all the tested samples showed certain level of DNA protection. The cytotoxic activity was assessed by using Sulforhodamine B (SRB) assay on human cell lines; H157 (Lung Carcinoma) and HT144 (Malignant Melanoma). The IC50 values of the tested samples ranged from 0.18 to 1.4 mg/mL against H157 cell line whereas against HT144 cell line the IC50 values ranged from 0.46 to 17.88 mg/mL with NBF fraction showing maximum potential for both. Furthermore, the phytochemical analysis of CME and its fractions showed the presences of flavonoids, saponins, tannins, terpenoides and cardiac glycosides with varying concentrations.

  13. Antihyperglycemic and antinociceptive activities of methanolic extract of Euphorbia thymifolia L. whole plants.

    Science.gov (United States)

    Rahmatullah, Mohammed; Hasan, Sumaiyah Kanij; Ali, Zulfiquar; Rahman, Shahnaz; Jahan, Rownak

    2012-02-01

    To study the antihyperglycemic and antinociceptive activities of methanolic extract of the whole plant of Euphorbia thymifolia L., a plant used in folk medicine of Bangladesh for treatment of diabetes and pain. Antihyperglycemic activity studies were conducted in glucose-loaded mice by oral glucose tolerance tests. Mice were given various doses of the extract, followed by glucose (2 g/kg body weight), 1 h after administration of the extract. Serum glucose levels were measured 2 h after glucose administration. Antinociceptive activity studies were conducted in intraperitoneally acetic acid-injected mice through measurement of reductions in abdominal writhing times caused by acetic acid-induced gastric pain. Following a period of 1 h after oral administration of various doses of the extract, all mice received intraperitoneal injection of 1% acetic acid at a dose of 10 mL/kg body weight. To ensure bioavailability of acetic acid, a period of 5 min was given to each animal following which period the number of writhings was counted for 10 min. The extract caused a significant dose-dependent reduction in serum glucose levels in mice, when administered at doses of 50, 100, 200 and 400 mg/kg body weight as compared to the control animals (Pweight, lowered serum glucose levels by 48.6%. The extract also demonstrated a significant dose-dependent antinociceptive activity compared to control animals (Pweight, the number of abdominal writhings was inhibited by 40.9% as compared to 49.0% inhibition obtained with a standard antinociceptive drug aspirin, administered at a dose of 200 mg/kg body weight. The significant antihyperglycemic and antinociceptive activities demonstrated by the extract validate the use of E. thymifolia in folk medicine of Bangladesh for treatment of diabetes and pain, and merit further scientific studies leading to discovery of efficacious drugs.

  14. Overexpression of the AtSHI gene in poinsettia, Euphorbia pulcherrima, results in compact plants.

    Science.gov (United States)

    Islam, M Ashraful; Lütken, Henrik; Haugslien, Sissel; Blystad, Dag-Ragnar; Torre, Sissel; Rolcik, Jakub; Rasmussen, Søren K; Olsen, Jorunn E; Clarke, Jihong Liu

    2013-01-01

    Euphorbia pulcherrima, poinsettia, is a non-food and non-feed vegetatively propagated ornamental plant. Appropriate plant height is one of the most important traits in poinsettia production and is commonly achieved by application of chemical growth retardants. To produce compact poinsettia plants with desirable height and reduce the utilization of growth retardants, the Arabidopsis SHORT INTERNODE (AtSHI) gene controlled by the cauliflower mosaic virus 35S promoter was introduced into poinsettia by Agrobacterium-mediated transformation. Three independent transgenic lines were produced and stable integration of transgene was verified by PCR and Southern blot analysis. Reduced plant height (21-52%) and internode lengths (31-49%) were obtained in the transgenic lines compared to control plants. This correlates positively with the AtSHI transcript levels, with the highest levels in the most dwarfed transgenic line (TL1). The indole-3-acetic acid (IAA) content appeared lower (11-31% reduction) in the transgenic lines compared to the wild type (WT) controls, with the lowest level (31% reduction) in TL1. Total internode numbers, bract numbers and bract area were significantly reduced in all transgenic lines in comparison with the WT controls. Only TL1 showed significantly lower plant diameter, total leaf area and total dry weight, whereas none of the AtSHI expressing lines showed altered timing of flower initiation, cyathia abscission or bract necrosis. This study demonstrated that introduction of the AtSHI gene into poinsettia by genetic engineering can be an effective approach in controlling plant height without negatively affecting flowering time. This can help to reduce or avoid the use of toxic growth retardants of environmental and human health concern. This is the first report that AtSHI gene was overexpressed in poinsettia and transgenic poinsettia plants with compact growth were produced.

  15. Antioxidant, antimicrobial, antitumor, and cytotoxic activities of an important medicinal plant (Euphorbia royleana from Pakistan

    Directory of Open Access Journals (Sweden)

    Aisha Ashraf

    2015-03-01

    Full Text Available The aim of present study was to evaluate antioxidant, antimicrobial, and antitumor activities of methanol, hexane, and aqueous extracts of fresh Euphorbia royleana. Total phenolic and flavonoid contents were estimated as gallic acid and querectin equivalents, respectively. Antioxidant activity was assessed by scavenging of free 2,2′- diphenyl-1-picrylhydrazyl radicals and reduction of ferric ions, and it was observed that inhibition values increase linearly with increase in concentration of extract. The results of ferric reducing antioxidant power assay showed that hexane extract has maximum ferric reducing power (12.70 ± 0.49 mg gallic acid equivalents/g of plant extract. Maximum phenolic (47.47 ± 0.71 μg gallic acid equivalents/mg of plant extract and flavonoid (63.68 ± 0.43 μg querectin equivalents/mg of plant extract contents were also found in the hexane extract. Furthermore, we examined antimicrobial activity of the three extracts (methanol, hexane, aqueous against a panel of microorganisms (Escherichia coli, Bacillus subtillis, Pasteurella multocida, Aspergillus niger, and Fusarium solani by disc-diffusion assay, and found the hexane extract to be the best antimicrobial agent. Hexane extract was also observed as to be most effective in a potato disc assay. As hexane extract showed potent activity in all the investigated assays, it was targeted for cytotoxic assessment. Maximum cytotoxicity (61.66% by hexane extract was found at 800 μg/mL. It is concluded that investigated extracts have potential for isolation of antioxidant and antimicrobial compounds for the pharmaceutical industry.

  16. Eutirucallin, a RIP-2 Type Lectin from the Latex of Euphorbia tirucalli L. Presents Proinflammatory Properties

    Science.gov (United States)

    Santana, Sanzio Silva; Gennari-Cardoso, Margareth Leitão; Carvalho, Fernanda Caroline; Roque-Barreira, Maria Cristina; Santiago, André da Silva; Alvim, Fátima Cerqueira; Pirovani, Carlos Priminho

    2014-01-01

    Lectins are carbohydrate-binding proteins that recognize and modulate physiological activities and have been used as a toll for detection and identification of biomolecules, and therapy of diseases. In this study we have isolated a lectin present in the latex of Euphorbia tirucalli, and named it Eutirucallin. The latex protein extract was subjected to ion exchange chromatography and showed two peaks with haemagglutinating activity. Polypeptides of 32 kDa protein extract strongly interacted with immobilized galactose (α-lactose > D-N-acetylgalactosamine). The Eutirucallin was obtained with a yield of 5.6% using the α-lactose column. The lectin domain has 32 kDa subunits and at least two of which are joined by disulfide bridges. The agglutinating capacity for human erythrocytes A+, B+ and O+ is inhibited by D-galactose. The haemagglutinating activity of Eutirucallin was independent of Ca2+ and maintained until the temperature of 55°C. Eutirucallin presented biological activities such as neutrophils recruitment and cytokine prodution by macrophages. The analysis of the trypsin-digested Eutirucallin by ms/ms in ESI-Q-TOFF resulted in nine peptides similar to type 2 ribosome-inactivating protein (type-2 RIP). It's partial sequence showed a similarity of 67.4 – 83.1% for the lectin domain of type-2 RIP [Ricin and Abrin (83.1%), Viscumin, Ebulin, Pulchellin, Cinnamomin, Volkensin and type-2 RIP Iris hollandica]. Our data suggest that Eutirucallin is a new member of type 2 ribosome-inactivating protein and presents biotechnological potential. PMID:24558388

  17. Overexpression of the AtSHI gene in poinsettia, Euphorbia pulcherrima, results in compact plants.

    Directory of Open Access Journals (Sweden)

    M Ashraful Islam

    Full Text Available Euphorbia pulcherrima, poinsettia, is a non-food and non-feed vegetatively propagated ornamental plant. Appropriate plant height is one of the most important traits in poinsettia production and is commonly achieved by application of chemical growth retardants. To produce compact poinsettia plants with desirable height and reduce the utilization of growth retardants, the Arabidopsis SHORT INTERNODE (AtSHI gene controlled by the cauliflower mosaic virus 35S promoter was introduced into poinsettia by Agrobacterium-mediated transformation. Three independent transgenic lines were produced and stable integration of transgene was verified by PCR and Southern blot analysis. Reduced plant height (21-52% and internode lengths (31-49% were obtained in the transgenic lines compared to control plants. This correlates positively with the AtSHI transcript levels, with the highest levels in the most dwarfed transgenic line (TL1. The indole-3-acetic acid (IAA content appeared lower (11-31% reduction in the transgenic lines compared to the wild type (WT controls, with the lowest level (31% reduction in TL1. Total internode numbers, bract numbers and bract area were significantly reduced in all transgenic lines in comparison with the WT controls. Only TL1 showed significantly lower plant diameter, total leaf area and total dry weight, whereas none of the AtSHI expressing lines showed altered timing of flower initiation, cyathia abscission or bract necrosis. This study demonstrated that introduction of the AtSHI gene into poinsettia by genetic engineering can be an effective approach in controlling plant height without negatively affecting flowering time. This can help to reduce or avoid the use of toxic growth retardants of environmental and human health concern. This is the first report that AtSHI gene was overexpressed in poinsettia and transgenic poinsettia plants with compact growth were produced.

  18. [Friedrich Ludwig von Maydelli pildid Baltimaade ajaloost = Friedrich Ludwig von Maydells Baltische Geschichte in Bildern = Friedrich Ludwig von Maydell ́s Baltic history in images] / Ulrike Plath

    Index Scriptorium Estoniae

    Plath, Ulrike, 1972-

    2014-01-01

    Arvustus: Friedrich Ludwig von Maydelli pildid Baltimaade ajaloost = Friedrich Ludwig von Maydells Baltische Geschichte in Bildern = Friedrich Ludwig von Maydell ́s Baltic history in images. Eesti kunstimuuseum, Kadrioru kunstimuuseum. Tallinn 2013

  19. Impact of black rhinoceros (Diceros bicornis minor) on a local population of Euphorbia bothae in the Great Fish River Reserve, South Africa

    NARCIS (Netherlands)

    Luske, B.L.; Mertens, T.; Lent, P.C.; Boer, de W.F.; Prins, H.H.T.

    2009-01-01

    In the Great Fish River Reserve, South Africa, black rhinoceros (Diceros bicornis minor) feed extensively on a local population of Euphorbia bothae. Maintaining the endangered black rhinoceros and the protected E. bothae population are both conservation priorities of the reserve. Therefore, the

  20. Procedimiento para aumentar la síntesis y acumulación de hidrocarburos naturales derivados del metabolismo terpenoide en la planta euphorbia lathyris

    OpenAIRE

    Balaguer Zamora, Begoña; Castelblanque Soriano, Lourdes; Martí-Ibáñez, María Cristina; Ramírez García, Vicente; Vera, Pablo

    2011-01-01

    Procedimiento de obtención de biomasa enriquecida en triterpenos, caracterizado porque comprende tratar la planta Euphorbia lathyris con al menos un jasmonato, preferentemente jasmonato de metilo. Así como la biomasa enriquecida en triterpenos obtenida por dicho procedimiento, su uso como fuente de combustible energético y método de obtención de dicho combustible.

  1. Chemical Composition and Mosquitocidal activity of n-Hexane and Methanol Extracts from Euphorbia anacampseros var. tmolea, an endemic species of Turkey, against Aedes aegypti

    Science.gov (United States)

    New and safe mosquito control agents are necessary due to increasing resistance to synthetic insecticides and environmental change. The mosquito larvicidal and adulticidal activity and chemical composition of Euphorbia anacampseros var. tmolea extracts are investigated in this article for the first ...

  2. Methanic fermentation of Euphorbia tirucalli, a rich and renewable vegetal biomass of the Sahel and arid zones

    Energy Technology Data Exchange (ETDEWEB)

    Sow, D. [Dakar Univ. (Senegal); Depeyre, D.; Isambert, A. [Ecole Centrale des Arts et Manufactures, 92 - Chatenay-Malabry (France)

    1994-12-31

    A rich and renewable vegetal biomass is existing in Senegal. In fact Euphorbia tirucalli is a latex plant well adapted to sahelian climatic conditions, spread all along the country. In this work, methanic fermentation experimentations are made with this plant in a specific continuous fermentor named Transpaille. A 120 l biodigester was tested at 37 deg C with a piece-broken plant. The registered volumic efficiency is 0.80 l/l.d. With this interesting result, the same experiment was made with real operating conditions on a village digester in a farm. With a bioreactor of 12 m{sup 3}, incubated at ambient temperature, the obtained volumic efficiency is 0.61 l/l.d. The produced biogas of this experiment was used for food cooking and for farm milk cooling. This work shows that a vulgarization policy of the biogas way in rural conditions in Senegal is now possible with Euphorbia tirucalli. (authors). 19 refs., 6 figs., 2 tabs.

  3. Antifungal activity against Cryptococcus neoformans strains and genotoxicity assessment in human leukocyte cells of Euphorbia tirucalli L.

    Directory of Open Access Journals (Sweden)

    Luís Flávio Souza de Oliveira

    2014-12-01

    Full Text Available In the last times, focus on plant research has increased all over the world. Euphorbia tirucalli L., a plant known popularly as Aveloz, and originally used in Africa, has been drawing attention for its use in the United States and Latin America, both for use as an ornamental plant and as a medicinal plant. E. tirucalli L. is a member of the family Euphorbiaceae and contains many diterpenoids and triterpenoids, in particular phorbol esters, apparently the main constituent of this plant, which are assumed to be responsible for their activities in vivo and in vitro. The in vitro antifungal activities of Euphorbia tirucalli (L. against opportunistic yeasts were studied using microbroth dilution assay. The results showed that aqueous extract and latex preparation were effective against ten clinical strains of Cryptococcus neoformans in vitro (Latex and extract MIC range of 3.2 - > 411 µg/mL. Aiming the safe use in humans, the genotoxic effects of E. tirucalli were evaluated in human leukocytes cells. Our data show that both aqueous extract and latex preparation have no genotoxic effect in human leukocytes cells in vitro. Although the results cannot be extrapolated by itself for use in vivo, they suggest a good perspective for a therapeutic application in future. In conclusion, our results show that the aqueous extract and latex preparation from E. tirucalli L. are antifungal agents effectives against several strains of C. neoformans and do not provoke DNA damage in human leukocyte cells, considering the concentrations tested.

  4. Von den Veranschaulichungsmethoden in den Rundfunkpredigten von der Heiligkreuz- Kirche

    Directory of Open Access Journals (Sweden)

    Witold Ostafiński

    2004-12-01

    Full Text Available In der gegenwärtigen Verkündigung des Wortes Gottes spielt die Veranschaulichung der Überlieferung eine nicht zu überschätzende Rolle. Vor diesem Hintergrund wird es sehr wichtig, dass man den Predigern nicht nur auf die Funktion des Bildes in der Verkündigung, sondern auch auf die Art und Weise seines Entstehens auf der narrativen Ebene aufmerksam macht. Während die Kenner der Homiletik die Notwendigkeit des Auftretens der Bildeigenschaften in den Predigten betonen, erinnern sie gleichzeitig daran, dass der moderne, von der „Bild-Zivilisation“ gestaltete Mensch, „immer mehr sehen als hören“ möchte. Der vorliegende, die Rundfunkpredigten von der Heiligkreuz-Kirche analysierende Aufsatz, nimmt auf und bringt zugleich nahe die Problematik der Notwendigkeit des Bildes in der Wort-Gottes-Verkündigung. Der Artikel stellt die Erzählungsform als eine wichtige Möglichkeit der Glaubensüberlieferung dar, behandelt das Problem der Aktualisierung evangelischen Werte, bringt das von den Predigten gestaltete synästhetische Weltbild nahe und analysiert die Rolle des Zitats und Beispiels (exemplum bei der Gestaltung der Bildhaftigkeit einer Predigt. Darüber hinaus überprüft der Aufsatz in seinem letzten Teil die in den gegenwärtigen Rundfunkpredigten meist verwendeten Redefiguren

  5. Analyse von Schnittstellenkompatibilität von Steuergeräten auf Basis von MSC-Beschreibungen

    OpenAIRE

    Ma, Zheng

    2008-01-01

    In modernen Fahrzeugen befindet sich eine Vielzahl von Steuergeräten, die verschiedenste Funktionen, wie z.B. das Antiblockiersystem (ABS) realisieren. Die Funktionalitäten von Steuergeräten werden heute mit unterschiedlichen Methoden beschrieben. Eine dieser Methoden sind Message Sequence Charts (MSCs). Aufgrund der Freiheitsgrade von MSCs gibt es verschiedene Möglichkeiten gleiche Funktionalität unterschiedlich zu beschreiben. In dieser Arbeit wird eine Methode definiert, wie...

  6. Männlichkeiten von rechts

    Directory of Open Access Journals (Sweden)

    Marc Gärtner

    2004-11-01

    Full Text Available Oliver Geden, Doktorand am Institut für europäische Ethnologie der Humboldt Universität Berlin untersucht Männlichkeitskonzepte im zeitgenössischen Rechtspopulismus – ein Thema, zu dem überraschend lange keine einschlägigen Studien vorlagen. Anhand von Parteimedien und Interviews rekonstruiert er strategische Positionen zu Männlichkeit und Geschlechterverhältnissen auf unterschiedlichen Organisationsebenen der Österreichischen „Haider-Partei“ FPÖ. Statt eines monolithischen „Neo-Macho-Projektes“ findet er im Kern zwar ähnliche Traditionalisierungsbemühungen auf allen Ebenen, je nach Kontext aber differenzierbare pragmatische, verunsicherte und neo-naturalistische Perspektiven auf die Geschlechterthematik. Durch die Einbeziehung von Gruppeninterviews im Nachwuchsverband der Partei erhält die Publikation eine besondere Brisanz. Geden analysiert die methodischen und forschungsethischen Implikationen ebenso hervorragend wie das Kernthema selbst.

  7. Von Willebrand factor and aging.

    Science.gov (United States)

    Konkle, Barbara A

    2014-09-01

    von Willebrand factor (VWF) plays critical roles in initiating primary hemostasis and extending the half-life of coagulation factor VIII in circulation. VWF levels increase with age and elevated levels are associated with an increased risk of venous thromboembolism and cardiovascular disease (CVD). Patients with von Willebrand disease (VWD) due to a deficiency or dysfunction of VWF may have symptoms that ameliorate with aging or may have exacerbation of their disease. Bleeding sites of particular challenge in the aging patient include gastrointestinal bleeding and hematuria. Some medications used to treat VWD should be used with special precaution in older patients, including desmopressin and VWF-containing factor concentrates. Patients with VWD may have some protection from CVD, but in those patients who develop CVD, management is very challenging, given the role of antiplatelet therapy as the mainstay of treatment. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  8. von Hippel-Lindau disease

    DEFF Research Database (Denmark)

    Binderup, Marie Louise Mølgaard; Gimsing, Steen; Kosteljanetz, Michael

    2013-01-01

    Endolymphatic sac tumours (ELSTs) of the inner ear occur in 16% of patients with the hereditary tumor syndrome von Hippel-Lindau disease (vHL). ELSTs of all sizes can cause irreversible hearing loss which can, however, be prevented through early diagnosis and treatment. We aim to emphasize the ch...... the challenges of prophylactic ELST screening and to explore the role of audiometry in pre-symptomatic ELST screening....

  9. Methode zur Entwicklung von Prozessportalen

    OpenAIRE

    Alt, Rainer; Caesar, Marc; Leser, Florian; Österle, Hubert; Puschmann, Thomas; Reichmayr, Christian; Zurmuehlen, Rudolf

    2004-01-01

    Die in Kapitel 2 dargestellte Architektur zeigt Gestaltungselemente auf den drei Ebenen Strategie, Prozess und System. Zahlreiche Beispiele in den darauf folgenden Kapiteln haben die Anwendung dieser Architektur gezeigt. Um ein intuitives Vorgehen bei Entwurf und der Umsetzung von Echtzeit-Portalen zu vermeiden, sollen die bei den Fallbeispielen erzielten Erkenntnisse und Erfahrungen in ein systematisches Vorgehen einfliessen. Obgleich sich der Entwurf einer Architektur für das Echtzeit-Unter...

  10. Euphorbia tirucalli L.: Review on morphology, medicinal uses, phytochemistry and pharmacological activities

    Directory of Open Access Journals (Sweden)

    Prashant Y. Mali

    2017-07-01

    Full Text Available The intention of current review is to make available up-to-date information on morphology, ecological biodiversity, medicinal uses, phytochemistry and pharmacological activities on different parts of Euphorbia tirucalli (E. tirucalli. This plant has a number of medicinal uses. Latex of E. tirucalli is vesicant and rubefacient which is used for rheumatism, warts, cough, asthma, ear-ache, tooth-ache and neuralgia. It acts as a purgative in small doses while in big doses it is bitter irritant and emetic. Milky juice is alexiteric, carminative and purgative. It is useful in whooping cough, gonorrhea, asthma, leprosy, dropsy, dyspepsia, enlargement of spleen, colic, jaundice and stone in bladder. The fresh milky juice is good alternative in syphilis and a good application in neuralgia. A decoction of branches is used in gastralgia and colic. Bark is used in treatment of fractures. Poultices prepared from the stem are useful to repair the broken bones. Boiled root liquid acts as an emetic in cases of snake-bite and for infertility in women. The wood is used for rafters, toys and veneering purposes. It is also useful against leprosy and foot paralysis subsequent to childbirth. E. tirucalli is reported to have euphol, β-sitosterol, euphorbol hexacosonate, cycloeuphordenol, cyclotirucanenol, tirucalicine, tri-methyl ellagic acid, gallic acids, terpenic alcohol, isoeuphorol, taraxasterol, tirucallol, euphorone, euphorcinol, euphorbins, 12-deoxy-4β-hydroxyphorbol-13-phenyl acetate-20-acetate, 12, 20-dideoxyphorbol-13-isobutyrate, glut-5-en-3-β-ol, 3,3′-di-O-methylellagic acid, euphorbin-A (polyphenol, tirucallin-A (7 (tannin, tirucallin-B (11, euphorbin-F (14 (dimers, cycloartenol, 24-methylenecycloartenol, ingenol triacetate, 12-deoxy-4β-hydroxyphorbol-13-phenyl acetate-20-acetate, taraxerone, euphorginol, taraxerol, campesterol, stigmasterol, palmitic acid, linoleic acid, β-amyrin, etc. active phytoconstituents. E. tirucalli have possessed

  11. Chemical profile and defensive function of the latex of Euphorbia peplus.

    Science.gov (United States)

    Hua, Juan; Liu, Yan; Xiao, Chao-Jiang; Jing, Shu-Xi; Luo, Shi-Hong; Li, Sheng-Hong

    2017-04-01

    Plant latex is an endogenous fluid secreted from highly specialized laticifer cells and has been suggested to act as a plant defense system. The chemical profile of the latex of Euphorbia peplus was investigated. A total of 13 terpenoids including two previously unknown diterpenoids, (2S*,3S*,4R*,5R*,6R*,8R*,l1R*,13S*,14S*,15R*, 16R*)-5,8,15-triacetoxy-3-benzoyloxy-11,16-dihydroxy-9-oxopepluane and (2R*,3R*, 4S*,5R*,7S*,8S*,9S*,l3S*,14S*,15R*)-2,5,8,9,14-pentaacetoxy-3-benzoyloxy-15-hydroxy-7-isobutyroyloxyjatropha-6(17),11E-diene), ten known diterpenoids, and a known acyclic triterpene alcohol peplusol, were identified, using HPLC and UPLC-MS/MS analyses and through comparison with the authentic compounds isolated from the whole plant. The diterpenoids exhibited significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera), with EC 50 values ranging from 0.36 to 4.60 μg/cm 2 . In particular, (2R*,3R*,4S*,5R*,7S*,8S*,9S*,l3S*,14S*,15R*)-2,5,9,14-tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-7-isobutyroyloxyjatropha-6(17),11E-diene and (2R*,3R*, 4S*,5R*,7S*,8S*,9S*,l3S*,14S*,15R*)-2,5,14-triacetoxy-3-benzoyloxy-8,15-dihydroxy-7-isobutyroyloxy-9-nicotinoyloxyjatropha-6(17),11E-diene had EC 50 values of 0.36 and 0.43 μg/cm 2 , respectively, which were approximately 7-fold more potent than commercial neem oil (EC 50  = 2.62 μg/cm 2 ). In addition, the major peplusol showed obvious antifungal activity against three strains of agricultural phytopathogenic fungi, Rhizoctonia solani, Colletotrichum litchi and Fusarium oxysporum f. sp. niveum. The results indicated that terpenoids in the latex of E. peplus are rich and highly diversified, and might function as constitutive defense metabolites against insect herbivores and pathogens for the plant. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Einfluss von Hypoxie auf das Transkriptom und das mitochondriale Proteom von Arabidopsis thaliana

    OpenAIRE

    Willeke, Claudia

    2011-01-01

    Hypoxie beeinflusst Wachstum und Entwicklung von Pflanzen. Da Sauerstoff als finaler Elektronenakzeptor der Atmungskette dient, sind Mitochondrien möglicherweise an der Wahrnehmung von Hypoxie und der Weiterleitung des Signals durch retrograde Regulierung beteiligt. In dieser Arbeit wurden daher die Auswirkungen von Hypoxie auf das Transkriptom und das mitochondriale Proteom von Arabidopsis thaliana untersucht. Zu diesem Zweck wurden Inkubationssysteme für Zellkulturen, Keimlinge und Pflanzen...

  13. Dr. von Braun Briefing Walt Disney

    Science.gov (United States)

    1965-01-01

    Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

  14. Offenes Baukastensystem zur effizienten Dimensionierung von Materialflusssystemen

    OpenAIRE

    Meinhardt, Ingolf; Marquardt, Hans-Georg

    2007-01-01

    Die optimale Gestaltung logistischer Systeme und Prozesse bekommt eine immer größere Bedeutung für die Wirtschaftlichkeit und Wettbewerbsfähigkeit von Unternehmen. Für Einzelkomponenten von Materi-alflusssystemen sind neben exakten analytischen Verfahren auch Näherungslösungen und Ersatzmodelle in Form von Polynomen, neuronalen Netzen oder zeitdiskreten Verfahren vorhanden, mit denen eine gute Nachbildung des Verhaltens dieser Komponenten möglich ist. Ziel des Baukastensystems ist es, für...

  15. von Willebrand disease phenotype and von Willebrand factor marker genotype in Doberman Pinschers.

    Science.gov (United States)

    Brooks, M B; Erb, H N; Foureman, P A; Ray, K

    2001-03-01

    To define the relationship between clinical expression of a type-1 von Willebrand disease phenotype and genotype at 2 von Willebrand factor marker loci in Doberman Pinschers. 102 client-owned Doberman Pinschers. Dogs were recruited on the basis of plasma von Willebrand factor concentration, clinical history, and pedigree. Blood samples and response to a history questionnaire were obtained for each dog. Plasma von Willebrand factor concentration was measured by use of an ELISA, and genotyping was performed via polymerase chain reaction for 1 intragenic and 1 extragenic von Willebrand factor marker. Amplification product size was determined by use of polyacrylamide gel electrophoresis (intragenic marker) or automated sequence analysis (extragenic marker). Western blots were prepared from a subset of dogs with low plasma von Willebrand factor concentration to evaluate multimer distribution. Strong associations were detected between plasma von Willebrand factor concentration and von Willebrand factor marker genotype. Twenty-five dogs had substantial reduction in plasma von Willebrand factor concentration and multiple hemorrhagic events. All were homozygous for a 157-base-pair intragenic marker allele and homozygous or compound heterozygous for 1 of 4 extragenic marker alleles. These marker genotypes were exclusively detected in dogs with low plasma von Willebrand factor concentration, although some dogs with these genotypes did not have abnormal bleeding. Type-1 von Willebrand disease in Doberman Pinschers is associated with the von Willebrand factor gene locus; however, the expression pattern in this breed appears more complex than that of a simple recessive trait.

  16. Modellierung von Anwenderverhalten im Social Semantic Web

    Science.gov (United States)

    Ulbrich, Armin; Höfler, Patrick; Lindstaedt, Stefanie

    Ziel dieses Kapitels ist es, gemeinsame Verwendungsszenarien des Semantic Web und des Social Web zu identifizieren und zu benennen. Dabei wird ein Teilaspekt des Themengebiets im Detail betrachtet: die Nutzung von Services, die Beobachtungen des Verhaltens von Anwendern analysieren, um daraus maschinell interpretierbare Informationen zu erhalten und diese als Modelle zu organisieren. Es werden zunächst einige Eigenschaften und Unterscheidungsmerkmale von Anwenderverhalten und organisierten Modellen dargestellt. Anschließend wird der mögliche wechselseitige Nutzen von Anwenderverhalten und Modellen diskutiert. Den Abschluss bildet eine Betrachtung einiger exemplarischer Software-Services, die heute schon verwendet werden, um Anwenderverhalten in Modelle überzuführen.

  17. The Social Science of Carl von Clausewitz

    Science.gov (United States)

    2006-01-01

    The Social Science of Carl von Clausewitz JANEEN KLINGER C arl von Clausewitz’s great, unfinished book On War is well-known as be- ing prone to...COVERED 00-00-2006 to 00-00-2006 4. TITLE AND SUBTITLE The Social Science of Carl von Clausewitz 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...Raymond Aron, Clausewitz: Philos- opher of War (New York: Simon and Schuster, 1983), p. 206. 88 Parameters 2. Carl Von Clausewitz , On War, ed. and trans

  18. Die naturräumliche Gliederung von Schwaben

    OpenAIRE

    Fischer, Klaus

    1985-01-01

    Die naturräumliche Gliederung von Schwaben. - In: Historischer Atlas von Bayerisch-Schwaben / hrsg. von Hans Frei ... - 2., neu bearb. u. erg. Aufl. - Augsburg : Schwäb. Forschungsgem. - Lifg. 2. (1985). - Kt. II, 7.

  19. Optimisation of Ultrasound-Assisted Extraction Conditions for Phenolic Content and Antioxidant Capacity from Euphorbia tirucalli Using Response Surface Methodology

    Directory of Open Access Journals (Sweden)

    Quan V. Vuong

    2014-09-01

    Full Text Available Euphorbia tirucalli (E. tirucalli is now widely distributed around the world and is well known as a source of traditional medicine in many countries. This study aimed to utilise response surface methodology (RSM to optimise ultrasonic-assisted extraction (UAE conditions for total phenolic compounds (TPC and antioxidant capacity from E. tirucalli leaf. The results showed that ultrasonic temperature, time and power effected TPC and antioxidant capacity; however, the effects varied. Ultrasonic power had the strongest influence on TPC; whereas ultrasonic temperature had the greatest impact on antioxidant capacity. Ultrasonic time had the least impact on both TPC and antioxidant capacity. The optimum UAE conditions were determined to be 50 °C, 90 min. and 200 W. Under these conditions, the E. tirucalli leaf extract yielded 2.93 mg GAE/g FW of TPC and exhibited potent antioxidant capacity. These conditions can be utilised for further isolation and purification of phenolic compounds from E. tirucalli leaf.

  20. Notes on Euphorbia mauritanica, E. gossypina and some related species with an amplified description of E. berotica

    Directory of Open Access Journals (Sweden)

    L. C. Leach

    1975-11-01

    Full Text Available Some aspects of the possible evolutionary development in the Euphorbia mauritanica—lateriflora—gossypina complex are discussed, and the seed morphology is considered probably to be of considerable significance in the taxonomy of the group. The relevance of the recently discovered relic population of  E. gossypina is also considered, and a detailed description of this species, based on the Rhodesian material, is provided. The identity of the little known  E. berotica N.E. Br. from Angola is established and an amplified description drawn up. Attention is also given to the confusion concerning the type locality and distribution  of E.  mauritanica L. var.  lignosa White, Dyer & Sloane.

  1. Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias

    Directory of Open Access Journals (Sweden)

    Rosa Magán

    2004-10-01

    Full Text Available There is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops. We tested three triazolo-pyrimidine complexes [two with Pt(II, and another with Ru(III] against promastigotes of Phytomonas sp. isolated from Euphorbia characias. The incorporation of radiolabelled precursors, ultrastructural alterations and changes in the pattern of metabolite excretion were examined. Different degrees of toxicity were found for each complex: the platinun compound showed an inhibition effect on nucleic acid synthesis, provoking alterations on the levels of mitochondria, nucleus and glycosomes. These results, together with others reported previously in our laboratory about the activity of pyrimidine derivatives, reflect the potential of these compounds as agents in the treatment of Phytomonas sp.

  2. Four new compounds from the roots of Euphorbia ebracteolata and their inhibitory effect on LPS-induced NO production.

    Science.gov (United States)

    Bai, Jiao; Huang, Xue-Yan; Liu, Zhi-Guo; Gong, Chi; Li, Xin-Yu; Li, Da-Hong; Hua, Hui-Ming; Li, Zhan-Lin

    2018-03-01

    Three new diterpenoids, ebractenoids O~Q (1-3), and a new phenolic glucoside, γ-pyrone-3-O-β-d-(6-galloyl)-glucopyranoside (4), together with 6 known compounds, were isolated from the 95% ethanol extract of the roots of Euphorbia ebracteolata, and their structures were elucidated on the basis of spectroscopic data. The absolute configurations of 1-3 were determined by electronic circular dichroism (ECD) calculations. The inhibitory effects of all the isolates with exception of compounds 8 and 10 on the NO production in lipopolysaccharide (LPS)-induced macrophages were evaluated. All of them exhibited significant inhibitory activity. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Facile synthesis of silver nanoparticles using Euphorbia antiquorum L. latex extract and evaluation of their biomedical perspectives as anticancer agents

    Directory of Open Access Journals (Sweden)

    Chandrasekaran Rajkuberan

    2017-12-01

    Full Text Available This study reveals the rapid biosynthesis of silver nanoparticles (EAAgNPs using aqueous latex extract of Euphorbia antiquorum L as a potential bioreductant. Synthesized EAAgNPs generate the surface plasmonic resonance peak at 438 nm in UV–Vis spectrophotometer. Size and shape of EAAgNPs were further characterized through transmission electron microscope (TEM which shows well-dispersed spherical nanoparticles with size ranging from 10 to 50 nm. Energy dispersive X-ray spectroscopic analysis (EDAX confirms the presence of silver (Ag as the major constituent element. X-ray diffraction (XRD pattern of EAAgNPs corresponding to (111, (200, (220 and (311 planes, reveals that the generated nanoparticles were face centered cubic crystalline in nature. Interestingly, fourier-transform infrared spectroscopy (FTIR analysis shows the major role of active phenolic constituents in reduction and stabilization of EAAgNPs. Phyto-fabricated EAAgNPs exhibits significant antimicrobial and larvicidal activity against bacterial human pathogens as well as disease transmitting blood sucking parasites such as Culex quinquefasciatus and Aedes aegypti (IIIrd instar larvae. On the other hand, in vitro cytotoxicity assessment of bioformulated EAAgNPs has shown potential anticancer activity against human cervical carcinoma cells (HeLa. The preliminary biochemical (MTT assay and microscopic studies depict that the synthesized EAAgNPs at minimal dosage (IC50 = 28 μg triggers cellular toxicity response. Hence, the EAAgNPs can be considered as an environmentally benign and non-toxic nanobiomaterial for biomedical applications. Keywords: Crystal structure, Euphorbia antiquorum L., Silver nanoparticles, Anticancer, Human pathogens

  4. Planung von CLIL-Unterricht

    Directory of Open Access Journals (Sweden)

    Josef Leisen

    2015-10-01

    Full Text Available Der Beitrag formuliert die Sprachlernbedingungen und die Leitlinien des Sprachlernens im Fach und nennt Merkmale des guten integrierten Fach- und Sprachlehrens. Ausgehend von den Sprachproblemen, die sich im CLIL-Unterricht auftun, wird der sprachsensible CLIL-Unterricht definiert, und es werden Anregungen zur Gestaltung gegeben. Sprachliche Standardsituationen umfassen die kommunikativen Situationen im CLIL-Unterricht, die beim fachlichen Lernen auftreten und von der CLIL-Lehrkraft professionell bewältigt werden müssen. Im Beitrag wird ein Lehr-Lern-Modell ausführlich beschrieben und erläutert. Die Steuerungen von Sprachlernprozessen im CLIL durch Aufgabenstellungen, Methoden-Werkzeuge, Moderation und Diagnose/Rückmeldung werden ausführlich beschrieben. Die Planung einer Lernlinie in sechs Schritten wird dargestellt und erläutert. Planungsraster für CLIL-Lernlinien schließen den Beitrag ab. The article sets out the conditions for language learning in general as well as guiding principles of language learning in the subject and puts forward criteria for successfully integrated content and language learning. Based on typical language problems arising in CLIL-classrooms, the language-sensitive CLIL-classroom is defined and organisational suggestions are given. Linguistic standard situations comprise the communicative situations in the CLIL-classroom which are encountered in subject-related learning and have to be professionally mastered by the CLIL-teacher. The article extensively describes and explains a model of teaching and learning that can be used for the CLIL-classroom. It gives detailed information on managing language learning processes in CLIL by means of tasks, resources and methods as well as discourse facilitation, evaluation and feedback. In addition, a six-step lesson unit is outlined and explained. The article concludes by giving a planning matrix for CLIL lesson units.

  5. Homoepitaxie von ZnO

    OpenAIRE

    Neumann, Christian

    2006-01-01

    Die Arbeit beschäftigt sich mit der homoepitaktischen Darstellung von ZnO-Dünnschichten. Die Arbeit beginnt mit einer theoretischen Betrachtung des Materialsystems und den daraus für eine erfolgreiche Epitaxie zu ziehenden Schlüssen. Es wurde eine Temperbehandlung zur Oberflächenmodifikation kommerziell erhältlicher ZnO-Einkristallsubstrate erarbeitet, die für eine erfolgreiche Epitaxie erforderlich ist. Im Anschluß daran wird die Entwicklung eines CVD-Prozesses mit metallischer Zin...

  6. Riidaja mõis / Elma von Stryk

    Index Scriptorium Estoniae

    Stryk, Elma von

    2006-01-01

    renoveerimise ootel barokne puithäärber (1762), kompleksi ümbritsev kivimüür, maakividest hobusetall, pargivaade, punastest tellistest neogooti stiilis kabel (1864), mis taastati von Strykkide perekonna toel. 11 ill.; fotod: Raivo Tasso; kabelis on Elma von Stryki loodud Kristust kujutav altarimaal

  7. Sorten- und Nachbaueignung von Hafer und Weizen

    OpenAIRE

    Spieß, Hartmut

    2000-01-01

    Der Beitrag gibt anhand alter und neuer Sortenvergleiche von Hafer und Weizen Einblick in die Problematik ökologischer Züchtung und Sortenwahl. Dabei geht es neben spezifischen Sorteneigenschaften um die Ausgewogenheit von Ertrags- und Qualitätsbildung im Verhältnis zur Pflanzengesundheit.

  8. Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced diabetic rats.

    Science.gov (United States)

    Tuhin, Riazul Haque; Begum, Mst Marium; Rahman, Md Sohanur; Karim, Rubaba; Begum, Taslima; Ahmed, Siraj Uddin; Mostofa, Ronia; Hossain, Amir; Abdel-Daim, Mohamed; Begum, Rayhana

    2017-08-24

    Euphorbia hirta linn., is a species of Euphorbiaceae family. They are known as asthma plant, barokhervi. The plant E. hirta is famous for its medicinal importance among the tribal population. It is a common practice to use the whole to heal wounds. Several pharmacological properties including antiseptic, anti-inflammatory, antidibetic, antispasmodic, antibacterial, antiviral, antifungal, anticonvulsant, nootropic, antifertility and aphrodisiac properties have already been reported for this plant. The aim of present work was to evaluate the wound healing property in diabetic animals by oral and topical administration of ethanolic extract of E. hirta whole plant. The ethanolic extract of E. hirta was subjected to determine the total phenolic content and total flavonoid content using galic acid and quercetin, respectively as standard. A single injection of alloxan monohydrate (120 mg/kg, i.p.) prepared in normal saline was administered to produce diabetes in rats, after overnight fasting. For analyzing the rate of contraction of wound, excision wounds sized 4.90cm2 and of 2 mm depth were used. Oral (100, 200 and 400 mg/kg/day; p.o.) and topical treatment with the extract (5% and 10% ointment 50 mg/kg/day) and standard (5% povidone iodine ointment 50 mg/kg/day) was started on the day of induction of wound and continued up to 16 days. The means of wound area measurement between groups at different time intervals were compared using ANOVA and Dunnet's test. The diabetic wound healing mechanism was studied by measuring the plasma level of glucose, malondialdehyde (MDA) and nitric oxide (NO) in both control and treated groups. For the confirmation of activity, histopathology of the wounds tissues from excision wound model was performed. Phytochemical investigations showed the presence of various phytoconstituents (carbohydrates, saponins, alkaloids, glycosides, steroids, flavonoids, tannins). In the ethanolic extract of E. hirta the total phenol content was 285

  9. Preliminary Investigation of Bioactive Compounds and Bioautographic Studies of Whole Plant Extract of Euphorbia pulcherrima on Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Pseudomonas aeruginosa

    Directory of Open Access Journals (Sweden)

    H. B. Sharif

    2015-01-01

    Full Text Available The aim of this study is to carry out preliminary investigation of bioactive compounds and bioautographic studies of whole plant extract of Euphorbia pulcherrima on Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Pseudomonas aeruginosa. Tukey HSD test of hierarchy for the effect of different solvents crude extract on bacterial isolates indicates the methanol extract as the most bioactive. The Tukey HSD analysis also showed that the bioactivities of the crude extracts of the various parts of Euphorbia pulcherrima were part dependent and the whole plant was the most bioactive. The ethyl acetate fraction of the methanol extract of the whole plant of Euphorbia pulcherrima has been shown in this work to contain phytochemicals which have shown remarkable activities against Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Pseudomonas aeruginosa. The bioactivities against the test organisms were due to the combined effects of the compounds separated on TLC plates. Families of terpenoids, flavonoids, alkaloids, saponin, and steroids that were detected in the extracts were identified by GC-MS. The various classes of phytochemicals in the E. pulcherrima plant provided the antimicrobial potency of the plant.

  10. Jacob Stael von Holstein ja palladionism eesti arhitektuuris / Ants Hein

    Index Scriptorium Estoniae

    Hein, Ants, 1952-

    2005-01-01

    Sõjaväeinsenerist ja arhitektist Jacob Stael von Holsteinist (1628, Pärnu-1679), tema kavandatud hoonetest ja rollist 17. sajandi II poole arhitektuuris. Fabian von Ferseni Toompeal Lossiplatsil asunud elamust (lammutati 1894) ja Maardu mõisahoonest, Hans von Ferseni Mäo mõisahoonest Järvamaal, Otto Wilhelm von Ferseni majast Toompeal, Axel von Roseni majast Tallinnas Pikk t. 28 (1670-74), Otto Reinhold von Taube majast Tartus (hävinud), J. S. von Holsteini enda hoonetest: majast Tallinnas Toompea 1, Anija mõisahoonest, elamust Riias jm. Bibliograafia lk. 452

  11. Neues über das Tertiär von Java und die mesozoischen Schichten von West-Borneo

    NARCIS (Netherlands)

    Martin, K.

    1888-01-01

    Die Monographie, welche unter dem Titel Die Fossilien von Java herausgegeben wird ¹), ist so weit fortgeschritten, dass sich aus den in ihr beschriebenen Gastropoden bereits eine Anzahl von Schlussfolgerungen ableiten lässt, welche für die in Bearbeitung begriffene, geologische Karte von Java von

  12. Indikatorenbasierte Bewertung von Entwurfsentscheidungen auf Systemebene

    Science.gov (United States)

    Freier, M.; Wenzler, A.; Mayer, T.; Gerlach, J.; Rosenstiel, W.

    2013-07-01

    Bei dem Entwurf von anwendungsspezifischen integrierten Schaltungen muss ein Entwickler zusätzliche Funktionen integrieren und die zunehmende Komplexität bewältigen. Für die Reduzierung der Kosten bleibt weiterhin die Verkürzung der benötigten Entwicklungszeit ein Ziel. Ein entscheidender Faktor dabei ist die zuverlässige Absicherung von Entwurfsentscheidungen in einer frühen Entwurfsphase. In der vorliegenden Arbeit wird eine Methode vorgestellt, die eine Bewertung von Entwurfsentscheidungen bei Systemmodellen mittels automatisch ermittelter Indikatoren ermöglichen soll. Die Systemmodelle können mit der Entwurfsumgebung MATLAB/Simulink oder in SystemC beschrieben sein.

  13. The Digital Von Fahrenheid Pyramid

    Science.gov (United States)

    Bura, M.; Janowski, J.; Wężyk, P.; Zięba, K.

    2017-08-01

    3D Scanners Lab from Digital Humanities Laboratory at the University of Warsaw initiated the scientific project, the purpose of which was to call attention to systematically penetrated and devastated pyramid-shaped tomb from the XVIII/XIX century, of family von Fahrenheid in Rapa in Banie Mazurskie commune (NE Poland). By conducting a series of non-invasive studies, such as 3D inventory using terrestrial laser scanning (TLS), thermal imaging, georadar measurements (around and inside the tomb) and anthropological research of mummified remains as well - the complete dataset was collected. Through the integration of terrestrial (TLS) and airborne laser scanning (ALS) authors managed to analyse the surroundings of Fahrenheid pyriamid and influence of some objects (like trees) on the condition and visibility of the Pyramids in the landscape.

  14. Khazanah: Friedrich Karl von Savigny

    Directory of Open Access Journals (Sweden)

    Atip Latipulhayat

    2015-04-01

    Full Text Available Friedrich Karl von Savigny (1779-1861 adalah ahli hukum Jerman yang juga dianggap sebagai salah satu Bapak hukum Jerman. Savigny adalah tokoh mazhab sejarah (historical school jurisprudence yang dikembangkannya pada paruh pertama abad ke 19. Dia juga dianggap sebagai pelopor kajian mengenai relasi antara perkembangan hukum dan sosial. Sebagai seorang pemikir hukum yang senantiasa kreatif dalam membuat terobosan-terobosan (trail-blazing legal scientist, Savigny memberikan kontribusi penting dalam perkembangan ilmu hukum dan bahkan terhadap ilmu sosial. Dari sekian banyak kontribusinya antara lain teorinya mengenai kontinuitas antara institusi hukum saat ini dengan institusi hukum masa lalu, meletakkan fondasi bagi kajian sosiologi hukum, dan menegaskan mengenai urgensi metode historis dalam kajian hukum.

  15. Evaluierung und Entwicklung von Methoden zur automatisierten Erfassung von Waldstrukturen aus Daten flugzeuggetragener Fernerkundungssensoren

    OpenAIRE

    Heurich, Marco

    2006-01-01

    Auf Grund der rasanten technologischen Entwicklung im Bereich der Sensorik sowie der Computerhard- und -software haben sich in den letzten Jahren neue Perspektiven zur Erforschung von Wäldern ergeben. Im Rahmen dieser durch die High-Tech-Offensive Bayern geförderten Arbeit wurde deshalb untersucht, inwieweit sich der Einsatz neuer Technologien zur automatisierten Erfassung von Waldstrukturen eignet. Als Voraussetzung dafür wurde zunächst ein Referenzgebiet zum Testen von Fernerkundungssensore...

  16. Spezifische Bindung von Aluminium und Eisen an den kationenselektiven Kanal MppA von Microthrix parvicella

    OpenAIRE

    Knaf, Tobias

    2013-01-01

    Schwermetallsalze wie beispielsweise Aluminium- oder Eisensalze werden in der Abwasserbehandlung zur Prävention und Bekämpfung von Blähschlamm, Schwimmschlamm und Schaumbildung verwendet. Dadurch kann eine Verbesserung der Schlammabsetzeigenschaften im Nachklärbecken erreicht werden. Übermäßiges Wachstum des grampositiven Bakteriums Microthrix parvicella gilt dabei als Hauptursache von Schlammabsetzproblemen und kann ebenfalls durch die Dosierung von schwermetallhaltigen Flockungs- und Fällun...

  17. Das Tumorsuppressorprotein p53 - Rolle bei der Induktion von Apoptose und bei der Replikation von Adenoviren

    OpenAIRE

    Koch, Philipp

    2003-01-01

    Das Tumorsuppressorgen p53 gehört zu den zentralen Steuereinheiten von Proliferation und Wachstum in der Zelle. Mutationen und funktioneller Verlust bei diesem Protein ist eng mit der Entstehung maligner Tumoren assoziiert. So kann man in über 50% aller soliden Tumoren Mutationen von p53 nachweisen. Es vermittelt seine Funktion hauptsächlich durch transkriptionelle Aktivierung p53-responsiver Gene. Folge der Aktivierung von p53 is...

  18. The crude latex of Euphorbia tirucalli modulates the cytokine response of leukocytes, especially CD4+ T lymphocytes

    Directory of Open Access Journals (Sweden)

    Bethânia A. Avelar

    2011-06-01

    Full Text Available The plants of the Euphorbiaceae family, especially those of the genus Euphorbia, are frequently used by Brazilian folk communities to treat a wide variety of infectious, tumoral and inflammatory illnesses. Among the species of this genus, Euphorbia tirucalli L. is widely used in some Brazilian regions, such as the Jequitinhonha River Valley. There is evidence that the latex produced by E. tirucalli has antiviral and antitumor activities, but little is known about the mechanisms involved in these effects. It is likely that the mechanism for such activities involves leukocyte activation and cytokine production. In this work, we aimed to evaluate the production of type 1 (TNF-α and IFN-γ and type 2 (IL-4 and IL-10 cytokines by circulating leukocyte subsets submitted to brief stimulation with the crude latex of E. tirucalli. Peripheral blood leukocytes of twenty healthy subjects were submitted to 4 h incubation with crude E. tirucalli latex diluted in dimethylsulfoxide. After the incubation period, the cells were stained with FITC-conjugated monoclonal antibodies specific to the cell surface receptors CD4, CD8 and CD14, and to PE-conjugated monoclonal antibodies specific to the cytokines TNF-α, IFN-γ, IL-4 and IL-10. The acquisition and analysis of data were performed by flow cytometry. The results showed a significant increase (p<0.05 in the percentage of CD4+ T lymphocytes positive for the type 1 cytokines TNF-α and IFN-γ. Neutrophils and CD8+ T lymphocytes showed a mixed profile of cytokine production, characterized by an increase in the percentage of cells expressing IFN-γ, TNF-α, and IL-10. The data indicate a predominant type 1 cytokine response. The findings presented suggest that the effect popularly attributed to E. tirucalli usage may be attributed to its effect on the production of TNF-α and IFN-γ. However, the relationship between the in vitro and in vivo effects of E. tirucalli needs to be investigated.

  19. How Is von Willebrand Disease Treated?

    Science.gov (United States)

    ... the condition. For example, the school nurse, teacher, daycare provider, coach, or any leader of afterschool activities ... MedlinePlus) Von Willebrand Disease (MedlinePlus) Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting ...

  20. How Is von Willebrand Disease Diagnosed?

    Science.gov (United States)

    ... the condition. For example, the school nurse, teacher, daycare provider, coach, or any leader of afterschool activities ... MedlinePlus) Von Willebrand Disease (MedlinePlus) Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting ...

  1. Johann Friedrich Wilhelm Adolf von Baeyer

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 19; Issue 6. Johann Friedrich Wilhelm Adolf von Baeyer: A Pioneer of Synthetic Organic Chemistry. Gopalpur Nagendrappa. General Article Volume 19 Issue 6 June 2014 pp 489-522 ...

  2. Genetics Home Reference: von Willebrand disease

    Science.gov (United States)

    ... Jun;5(6):1165-9. Citation on PubMed Kessler CM. Diagnosis and treatment of von Willebrand disease: ... consult with a qualified healthcare professional . About Selection Criteria for Links Data Files & API Site Map Customer ...

  3. Von Onlineplattformen und mittelalterlichen Märkten

    Directory of Open Access Journals (Sweden)

    Claudius Gräbner

    2017-12-01

    Full Text Available Mit der zunehmenden Digitalisierung und Vernetzung ökonomischer Systeme haben plattformbasierte Interaktionsbeziehungen stark an Bedeutung gewonnen. Hier werden zwei oder mehr Nutzungsgruppen durch eine dritte Seite, die Plattform, zusammengebracht. Die Interaktion wird in solchen zweiseitigen Märkten von den Plattformbetreibern kontrolliert. Kreditkartensysteme, Softwaremärkte oder werbefinanzierte Online-Communities stellen typische Beispiele dar. Da die Analyse von zweiseitigen Märkten mit Gleichgewichtsmodellen aufgrund der algebraischen Struktur des Problems in der Regel nicht praktikabel ist, präsentieren wir im vorliegenden Beitrag ein agentenbasiertes Modell, welches in einem kürzlich erschienenen Artikel ausführlicher diskutiert wird. Anhand von illustrativen Beispielen verdeutlichen wir die Implikationen eines agentenbasierten Ansatzes für die Innovationsökonomik im Allgemeinen und das Studium von Technologieentwicklung im Besonderen.

  4. Ist Pop die Volksmusik von heute?

    OpenAIRE

    Arbeitskreis Studium Populärer Musik

    1986-01-01

    Zugegeben, die Frage, ob Pop die Volksmusik von heute sei, ist provokant. Genau das war beabsichtigt. Sehr schnell erhielten wir auf unser Vorhaben, ein Seminar zu diesem Thema zu veranstalten, eine Vielzahl von Rückmeldungen. Pop-, Rock- und Jazzspezialisten, Musikwissenschaftler und Musikotiunologen fühlten sich animiert, Stellung zu beziehen und ein Referat zu halten. Intensive Diskussionen schlossen sich an, beflügelt auch durch die ansprechende Atmosphdre in der stil...

  5. Begehrte Körper jenseits von Geschlecht?

    Directory of Open Access Journals (Sweden)

    Corinna Tomberger

    2001-03-01

    Full Text Available Obwohl die visuelle Konstruktion des männlichen Körpers im Mittelpunkt von Daniel Wildmanns Studie steht, gelingt es ihm paradoxerweise, die Kategorie Geschlecht weitgehend zu ignorieren. In seiner Analyse des Films Olympia von Leni Riefenstahl zeigt der Autor auf, wie der ‚arische‘ Körper als Objekt des Begehrens für das Publikum entworfen wird.

  6. Dr. von Braun With German Rocket Experimenters

    Science.gov (United States)

    1930-01-01

    Dr. von Braun was among a famous group of rocket experimenters in Germany in the 1930s. This photograph is believed to be made on the occasion of Herman Oberth's Kegelduese liquid rocket engine being certified as to performance during firing. From left to right are R. Nebel, Dr. Ritter, Mr. Baermueller, Kurt Heinish, Herman Oberth, Klaus Riedel, Wernher von Braun, and an unidentified person.

  7. 50th birthday of Christian von Ferber

    Directory of Open Access Journals (Sweden)

    2011-06-01

    Full Text Available On May 15, 2011 Christian von Ferber - member of the Editorial Board of "Condensed Matter Physics" and renowned expert in the fields of soft matter physics and complex systems - celebrated his 50th birthday. The Editorial board of CMP, colleagues and friends warmy congratulate Christian von Ferber and wish him and his family continuing good health and to enjoy many adventures and discoveries in his future scientific travels!

  8. Dr. von Braun With Management Team

    Science.gov (United States)

    1961-01-01

    Dr. von Braun is shown in this photograph, which was probably taken in the early 1960s, with members of his management team. Pictured from left to right are, Werner Kuers, Director of the Manufacturing Engineering Division; Dr. Walter Haeussermarn, Director of the Astrionics Division; Dr. William Mrazek, Propulsion and Vehicle Engineering Division; Dr. von Braun; Dieter Grau, Director of the Quality Assurance Division; Dr. Oswald Lange, Director of the Saturn Systems Office; and Erich Neubert , Associate Deputy Director for Research and Development.

  9. Hullud päevad von Krahlis

    Index Scriptorium Estoniae

    2006-01-01

    Von Krahli Teatris mängitakse neil päevi neli korda Peeter Jalaka lavastuses Tõnu Kõrvitsa kammeroopereid "Tuliaed" ja "Mu luiged, mu mõtted", mille aluseks on luuletaja Marie Heibergi saatus. Libreto autor on Maarja Kangro. Kammerooperid tulevad lavale Von Krahli Teatri ja Nargen Opera koostöös. Esitavad Kädy Plaas, Helen Lokuta, Nargen Opera koor ja Tallinna Kammerorkester, dirigent Tõnu Kaljuste

  10. Visualisierung von typisierten Links in Linked Data

    Directory of Open Access Journals (Sweden)

    Georg Neubauer

    2017-09-01

    Full Text Available Das Themengebiet der Arbeit behandelt Visualisierungen von typisierten Links in Linked Data. Die wissenschaftlichen Gebiete, die im Allgemeinen den Inhalt des Beitrags abgrenzen, sind das Semantic Web, das Web of Data und Informationsvisualisierung. Das Semantic Web, das von Tim Berners Lee 2001 erfunden wurde, stellt eine Erweiterung zum World Wide Web (Web 2.0 dar. Aktuelle Forschungen beziehen sich auf die Verknüpfbarkeit von Informationen im World Wide Web. Um es zu ermöglichen, solche Verbindungen wahrnehmen und verarbeiten zu können sind Visualisierungen die wichtigsten Anforderungen als Hauptteil der Datenverarbeitung. Im Zusammenhang mit dem Sematic Web werden Repräsentationen von zuhammenhängenden Informationen anhand von Graphen gehandhabt. Der Grund des Entstehens dieser Arbeit ist in erster Linie die Beschreibung der Gestaltung von Linked Data-Visualisierungskonzepten, deren Prinzipien im Rahmen einer theoretischen Annäherung eingeführt werden. Anhand des Kontexts führt eine schrittweise Erweiterung der Informationen mit dem Ziel, praktische Richtlinien anzubieten, zur Vernetzung dieser ausgearbeiteten Gestaltungsrichtlinien. Indem die Entwürfe zweier alternativer Visualisierungen einer standardisierten Webapplikation beschrieben werden, die Linked Data als Netzwerk visualisiert, konnte ein Test durchgeführt werden, der deren Kompatibilität zum Inhalt hatte. Der praktische Teil behandelt daher die Designphase, die Resultate, und zukünftige Anforderungen des Projektes, die durch die Testung ausgearbeitet wurden.

  11. Anti-proliferation activity of terpenoids isolated from Euphorbia kansui in human cancer cells and their structure-activity relationship.

    Science.gov (United States)

    Hou, Jin-Jun; Shen, Yao; Yang, Zhou; Fang, Lin; Cai, Lu-Ying; Yao, Shuai; Long, Hua-Li; Wu, Wan-Ying; Guo, De-An

    2017-10-01

    Euphorbia kansui is a commonly used traditional Chinese medicine for the treatment of edema, pleural effusion, and asthma, etc. According to the previous researches, terpenoids in E. kansui possess various biological activities, e.g., anti-virus, anti-allergy, antitumor effects. In this work, twenty five terpenoids were isolated from E. kansui, including thirteen ingenane- and eight jatrophane-type diterpenoids (with two new compounds, kansuinin P and Q) and four triterpenoids. Eighteen of them were analyzed by MTS assay for in vitro anticancer activity in five human cancer cell lines. Structure-activity relationship for 12 ingenane-type diterpenoids in colorectal cancer Colo205 cells were preliminary studied. Significant anti-proliferation activities were observed in human melanoma cells breast cancer MDA-MB-435 cells and Colo205 cells. More than half of the isolated ingenane-type diterpenoids showed inhibitory activities in MDA-MB-435 cells. Eight ingenane- and one jatrophane-type diterpenoids possessed much lower IC50 values in MDA-MB-435 cells than positive control staurosporine. Preliminary structure-activity relationship analysis showed that substituent on position 20 was important for the activity of ingenane-type diterpenoids in Colo205 cells and substituent on position 3 contributed more significant biological activity of the compounds than that on position 5 in both MDA-MB-435 and Colo205 cells. Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  12. Multiple forms of endo-1,4-beta-glucanases in the endosperm of Euphorbia heterophylla L.

    Science.gov (United States)

    Suda, Cecilia N K; Giorgini, Jarbas F

    2003-09-01

    Germinating seeds of Euphorbia heterophylla L. contain endo-1,4-beta-glucanases which degrade carboxymethylcellulose (CMC). The activity decreased approximately 66% in extracts of endosperm containing isopropanol or ethanol. The endoglucanases were isolated from endosperm extracts using ammonium sulphate fractionation followed by Sephacryl S-100-HR chromatography resulting in two main peaks: I and II. Peak I endoglucanase was further purified about 15-fold on DEAE-Sephadex A50 and then by affinity chromatography (CF11-cellulose). Peak II endoglucanases were further purified 10-fold on CM-cellulose chromatography. The results indicated the occurrence of a 66 kDa endoglucanase (fractionated by SDS-PAGE and visualized by activity staining using Congo Red). Several acidic (pI 3.0 to 5.7) and basic (pI 8.5 to 10.0) forms from both peaks which differed in their capacities for degrading CMC or xyloglucans from Copaifera langsdorffii or Hymenaea courbaril were detected.

  13. Projection pursuit nonparametric regression applied to field counts of the aphid Macrosiphum euphorbiae (Homoptera: Aphididae) on tomato crops in greenhouses.

    Science.gov (United States)

    Boll, R; Lapchin, L

    2002-04-01

    The number of plants that sampling requires in aphid population studies often exceeds one hundred. Thus, only quick and nondestructive methods can be used to sample this pest in a reasonable time interval. We propose a visual method for estimating the density of the aphid Macrosiphum euphorbiae (Thomas) on tomato plants reared in greenhouses. After approximately 1min of visual observation plants can be assigned to abundance classes, the boundaries of which are roughly the powers of square root 10. Precise counts were collected simultaneously on sets of reference plants from the same greenhouse. Projection pursuit nonparametric regression was then used to provide unbiased estimates of aphid densities from the abundance classes and several easily gathered explanatory variables. The robustness of the method was evaluated by testing the models on the complementary data sets from plants in which the aphid densities were precisely counted. In both single and twin-row cultural conditions, for the reference and complementary data sets, the order of magnitude of the error was less than one class rank per plant. The investigation time was reduced by approximately 10-fold compared with the exact counting method. This easy-to-teach field method could be useful in large-scale population surveys and for optimizing integrated pest management strategies.

  14. Propiedad molusquicida de Euphorbia laurifolia A. Juss (Euphorbiaceae contra Biomphalaria glabrata Say hospedador intermediario de Schistosoma mansoni

    Directory of Open Access Journals (Sweden)

    José Ángel Mogollón-Morales

    2016-08-01

    Full Text Available En América Latina, los caracoles de Biomphalaria glabrata (Planorbidae son hospedadores intermediarios del parasito Schistosoma mansoni, agentes causantes de la schistosomiasis, una parasitosis que afecta a millones de personas en el mundo. El presente trabajo evalúa el papel de la especie Euphorbia laurifolia A. Juss (Euphorbiaceae contra B. glabrata. La actividad molusquicida se evaluó de acuerdo a los parámetros sugeridos por la Organización Mundial de la Salud. Se utilizaron caracoles de B. glabrata criados en el laboratorio. Se realizaron diferentes bioensayos utilizando extractos metanólico crudo, en n-hexano, en acetato de etilo y en metanol de las partes aéreas de E. laurifolia a diferentes concentraciones. Los resultados demostraron que esta especie posee una potente actividad letal con todos los extractos estudiados contra caracoles de B. glabrata, considerándose el mejor el extracto de acetato de etilo, el cual presentó una DL50 de 5,57 ppm.

  15. Euphorbia tirucalli L.-comprehensive characterization of a drought tolerant plant with a potential as biofuel source.

    Directory of Open Access Journals (Sweden)

    Bernadetta Rina Hastilestari

    Full Text Available Of late, decrease in mineral oil supplies has stimulated research on use of biomass as an alternative energy source. Climate change has brought problems such as increased drought and erratic rains. This, together with a rise in land degeneration problems with concomitant loss in soil fertility has inspired the scientific world to look for alternative bio-energy species. Euphorbia tirucalli L., a tree with C3/CAM metabolism in leaves/stem, can be cultivated on marginal, arid land and could be a good alternative source of biofuel. We analyzed a broad variety of E. tirucalli plants collected from different countries for their genetic diversity using AFLP. Physiological responses to induced drought stress were determined in a number of genotypes by monitoring growth parameters and influence on photosynthesis. For future breeding of economically interesting genotypes, rubber content and biogas production were quantified. Cluster analysis shows that the studied genotypes are divided into two groups, African and mostly non-African genotypes. Different genotypes respond significantly different to various levels of water. Malate measurement indicates that there is induction of CAM in leaves following drought stress. Rubber content varies strongly between genotypes. An investigation of the biogas production capacities of six E. tirucalli genotypes reveals biogas yields higher than from rapeseed but lower than maize silage.

  16. Phylogenetics of the Chamaesyce clade (Euphorbia, Euphorbiaceae): reticulate evolution and long-distance dispersal in a prominent C4 lineage.

    Science.gov (United States)

    Yang, Ya; Berry, Paul E

    2011-09-01

    The Chamaesyce clade of Euphorbia is the largest lineage of C(4) plants among the eudicots, with 350 species including both narrow endemics and cosmopolitan weeds. We sampled this group worldwide to address questions about subclade relationships, the origin of C(4) photosynthesis, the evolution of weeds, and the role of hybridization and long-distance dispersal in the diversification of the group. • Two nuclear (ITS and exon 9 of EMB2765) and three chloroplast markers (matK, rpl16, and trnL-F) were sequenced for 138 ingroup and six outgroup species. Exon 9 of EMB2765 was cloned in accessions with >1% superimposed peaks. • The Chamaesyce clade is monophyletic and consists of three major subclades [1(2,3)]: (1) the Acuta clade, containing three North American species with C(3) photosynthesis and C(3)-C(4) intermediates; (2) the Peplis clade, mostly North American and entirely C(4); and (3) the Hypericifolia clade, all C(4), with both New World and Old World groups. Incongruence between chloroplast and ITS phylogenies and divergent cloned copies of EMB2765 exon 9 suggest extensive hybridization, especially in the Hawaiian Islands radiation. • The Chamaesyce clade originated in warm, arid areas of North America, where it evolved C(4) photosynthesis. From there, it diversified globally with extensive reticulate evolution and frequent long-distance dispersals. Although many species are weedy, there are numerous local adaptations to specific substrates and regional or island radiations, which have contributed to the great diversity of this group.

  17. Comparative study on plant latex particles and latex coagulation in Ficus benjamina, Campanula glomerata and three Euphorbia species.

    Directory of Open Access Journals (Sweden)

    Georg Bauer

    Full Text Available Among latex-producing plants, mainly the latex of Hevea brasiliensis has been studied in detail so far, while comprehensive comparative studies of latex coagulation mechanisms among the more than 20,000 latex-bearing plant species are lacking. In order to give new insights into the potential variety of coagulation mechanisms, the untreated natural latices of five latex-bearing plants from the families Euphorbiaceae, Moraceae and Campanulaceae were visualised using Cryo-SEM and their particle size compared using the laser diffraction method. Additionally, the laticifers of these plants species were examined in planta via Cryo-SEM. Similar latex particle sizes and shape were found in Ficus benjamina and Hevea brasiliensis. Hence, and due to other similarities, we hypothesize comparable, mainly chemical, coagulation mechanisms in these two species, whereas a physical coagulation mechanism is proposed for the latex of Euphorbia spp. The latter mechanism is based on the huge amount of densely packed particles that after evaporation of water build a large surface area, which accelerates the coagulation procedure.

  18. Estudo botânico, fitoquímico e fisico-químico de Euphorbia hirta L. (Euphorbiaceae

    Directory of Open Access Journals (Sweden)

    M.V. Pinto

    2014-01-01

    Full Text Available Euphorbia hirta L., popularmente conhecida por erva andorinha, tem sido utilizada no tratamento de distúrbios respiratórios e como antiespasmódico. Esse trabalho foi realizado com a finalidade de determinar as características macroscópicas e microscópicas das folhas, caule e raiz dessa planta, uma vez que estas são as partes usadas popularmente. Algumas características de valor na sua diagnose foram apontadas e ilustradas por fotomicrografias. Reações de fitoquímica e a determinação do conteúdo de água e de cinzas foram realizadas no pó obtido da planta inteira, parte essa utilizada na fitoterapia Ayuverda. Na prospecção fitoquímica foram encontrados flavonóides, mucilagem, resinas e cumarinas. Na determinação do teor de água, de cinzas totais e de cinzas insolúveis em ácido, os valores encontrados foram 8,99%, 9,35%, 0,75%, respectivamente. Com o desenvolvimento deste trabalho foi possível obter parâmetros para o controle de qualidade das folhas, caule e raízes de E. hirta.

  19. The use of Euphorbia falcata extract as eco-friendly corrosion inhibitor of carbon steel in hydrochloric acid solution

    Energy Technology Data Exchange (ETDEWEB)

    El Bribri, A. [Laboratoire de Chimie Organique, Bioorganique et Environnement, Faculté des Sciences, Université Chouaib Doukkali, B.P. 20, M-24000 El Jadida (Morocco); Tabyaoui, M., E-mail: hamidtabyaoui@yahoo.fr [Laboratoire de Chimie Organique, Bioorganique et Environnement, Faculté des Sciences, Université Chouaib Doukkali, B.P. 20, M-24000 El Jadida (Morocco); Laboratoire des Matériaux, Nanoparticules et Environnement, Université Mohamed V Agdal, Faculté des Sciences, 4 Av. Ibn Battouta, B.P. 1014 RP, M-10000 Rabat (Morocco); Tabyaoui, B. [Laboratoire de Chimie Organique, Bioorganique et Environnement, Faculté des Sciences, Université Chouaib Doukkali, B.P. 20, M-24000 El Jadida (Morocco); El Attari, H.; Bentiss, F. [Laboratoire de Catalyse et de Corrosion des Matériaux (LCCM), Faculté des Sciences, Université Chouaib Doukkali, B.P. 20, M-24000 El Jadida (Morocco)

    2013-08-15

    Euphorbia falcata L. extract (EFE) was investigated as eco-friendly corrosion inhibitor of carbon steel in 1 M HCl using gravimetric, ac impedance, polarization and scanning electron microscopy (SEM) techniques. The experimental results show that EFE is good corrosion inhibitor and the protection efficiency is increased with the EEF concentration. The results obtained from weight loss and ac impedance studies were in reasonable agreement. Impedance experimental data revealed a frequency distribution of the capacitance, simulated as constant phase element. Polarization curves indicated that EFE is a mixed inhibitor. The corrosion inhibition was assumed to occur via adsorption of EFE molecules on the metal surface. The adsorption of the E. falcata extract was well described by the Langmuir adsorption isotherm. The calculated ΔG{sub ads}{sup o} value showed that the corrosion inhibition of the carbon steel in 1 M HCl is mainly controlled by a physisorption process. - Graphical abstract: Display Omitted - Highlights: • EFE is a good eco-friendly inhibitor for the corrosion of carbon steel in 1 M HCl. • EFE acts as mixed-type inhibitor in 1 M HCl medium. • Weight loss, ac impedance and polarization methods are in reasonable agreement. • The adsorption of EFE is well described by the Langmuir adsorption isotherm.

  20. Comparative study on plant latex particles and latex coagulation in Ficus benjamina, Campanula glomerata and three Euphorbia species.

    Science.gov (United States)

    Bauer, Georg; Gorb, Stanislav N; Klein, Marie-Christin; Nellesen, Anke; von Tapavicza, Max; Speck, Thomas

    2014-01-01

    Among latex-producing plants, mainly the latex of Hevea brasiliensis has been studied in detail so far, while comprehensive comparative studies of latex coagulation mechanisms among the more than 20,000 latex-bearing plant species are lacking. In order to give new insights into the potential variety of coagulation mechanisms, the untreated natural latices of five latex-bearing plants from the families Euphorbiaceae, Moraceae and Campanulaceae were visualised using Cryo-SEM and their particle size compared using the laser diffraction method. Additionally, the laticifers of these plants species were examined in planta via Cryo-SEM. Similar latex particle sizes and shape were found in Ficus benjamina and Hevea brasiliensis. Hence, and due to other similarities, we hypothesize comparable, mainly chemical, coagulation mechanisms in these two species, whereas a physical coagulation mechanism is proposed for the latex of Euphorbia spp. The latter mechanism is based on the huge amount of densely packed particles that after evaporation of water build a large surface area, which accelerates the coagulation procedure.

  1. Extracts of Euphorbia hirta Linn. (Euphorbiaceae) and Rauvolfia vomitoria Afzel (Apocynaceae) demonstrate activities against Onchocerca volvulus microfilariae in vitro.

    Science.gov (United States)

    Attah, Simon K; Ayeh-Kumi, Patrick F; Sittie, Archibald A; Oppong, Isaac V; Nyarko, Alexander K

    2013-03-18

    Onchocerciasis transmitted by Onchocerca volvulus is the second major cause of blindness in the world and it impacts negatively on the socio-economic development of the communities affected. Currently, ivermectin, a microfilaricidal drug is the only drug recommended for treating this disease. There have been speculations, of late, concerning O. volvulus resistance to ivermectin. Owing to this, it has become imperative to search for new drugs. World-wide, ethnomedicines including extracts of Euphorbia hirta and Rauvolfia vomitoria are used for treating various diseases, both infectious and non-infectious. In this study extracts of the two plants were evaluated in vitro in order to determine their effect against O. volvulus microfilariae. The toxicity of the E. hirta extracts on monkey kidney cell (LLCMK2) lines was also determined. The investigations showed that extracts of both plants immobilised microfilariae at different levels in vitro and, therefore, possess antifilarial properties. It was found that all the E. hirta extracts with the exception of the hexane extracts were more effective than those of R. vomitoria. Among the extracts of E. hirta the ethyl acetate fraction was most effective, and comparable to that of dimethanesulphonate salt but higher than that of Melarsoprol (Mel B). However, the crude ethanolic extract of E. hirta was found to be the least toxic to the LLCMK2 compared to the fractionated forms. Extracts from both plants possess antifilarial properties; however, the crude extract of E. hirta was found to be least toxic to LLCMK2.

  2. Avaliação da atividade moluscicida do látex de três espécies de Euphorbia (Euphorbiaceae) sobre Leptinaria unilamellata d'Orbigny, 1835 (Gastropoda - Subulinidae)

    OpenAIRE

    Afonso-Neto,I.S; Bessa,E.A; Soares,G.L.G

    2010-01-01

    Gastrópodes pulmonados terrestres podem atuar como hospedeiros intermediários de helmintos. Os primeiros registros do controle químico desses invertebrados datam do início do século XX e as substâncias utilizadas eram toxinas inespecíficas já empregadas no controle de outras pragas. Moluscicidas sintéticos apresentam limitações técnicas que estimularam a busca de substitutos naturais. Dentre as várias espécies vegetais com atividade moluscicida, Euphorbia cotinifolia L., Euphorbia milii des M...

  3. Interaction between the New World begomovirus Euphorbia yellow mosaic virus and its associated alphasatellite: effects on infection and transmission by the whitefly Bemisia tabaci.

    Science.gov (United States)

    Mar, Talita Bernardon; Mendes, Igor Rodrigues; Lau, Douglas; Fiallo-Olivé, Elvira; Navas-Castillo, Jesús; Alves, Murilo Siqueira; Murilo Zerbini, F

    2017-06-01

    The majority of Old World monopartite begomoviruses (family Geminiviridae) are associated with satellite DNAs. Alphasatellites are capable of autonomous replication, but depend on the helper virus for movement, encapsidation and transmission by the insect vector. Recently, Euphorbia yellow mosaic alphasatellite (EuYMA) was found in association with Euphorbia yellow mosaic virus (EuYMV) infecting Euphorbia heterophylla plants in Brazil. The geographical range of EuYMA was assessed in a representative sampling of E. heterophylla plants collected in several states of Brazil from 2009 to 2014. Infectious clones were generated and used to assess the phenotype of viral infection in the presence or absence of the alphasatellite in tomato, E. heterophylla, Nicotiana benthamiana, Arabidopsis thaliana and Crotalaria juncea. Phenotypic differences of EuYMV infection in the presence or absence of EuYMA were observed in A. thaliana, N. benthamiana and E. heterophylla. Symptoms were more severe when EuYMV was inoculated in combination with EuYMA in N. benthamiana and E. heterophylla, and the presence of the alphasatellite was determinant for symptom development in A. thaliana. Quantification of EuYMV and EuYMA indicated that EuYMA affects the accumulation of EuYMV during infection on a host-dependent basis. Transmission assays indicated that EuYMA negatively affects the transmission of EuYMV by Bemisia tabaci MEAM1. Together, these results indicate that EuYMA is capable of modulating symptoms, viral accumulation and whitefly transmission of EuYMV, potentially interfering with virus dissemination in the field.

  4. Aplicação do fomesafen via água de irrigação por aspersão no controle de Euphorbia heterophylla Application of fomesafen via overhead sprinkler irrigation for the control of Euphorbia heterophylla

    Directory of Open Access Journals (Sweden)

    R.A.A. Ruas

    2005-09-01

    Full Text Available A aplicação de herbicidas via água de irrigação (herbigação por aspersão, especialmente por pivô central, vem crescendo no Brasil. O objetivo deste estudo foi investigar a eficácia de doses de fomesafen aplicado via água de irrigação por aspersão no controle de Euphorbia heterophylla. Os tratamentos foram dispostos no esquema fatorial (4 x 3 x 2 + 3, sendo quatro doses do fomesafen (60, 120, 180 e 240 g ha-1, três estádios de desenvolvimento de E. heterophylla (1, 7 e 14 dias após a emergência - DAE, dois métodos de aplicação (pulverização e herbigação e testemunhas sem herbicida (uma para cada estádio de desenvolvimento da planta daninha. Foi empregado o delineamento inteiramente casualizado, com quatro repetições. Cada unidade experimental constou de um vaso com 4,0 L de solo, onde foram distribuídas 50 sementes dessa planta daninha. A pulverização foi feita com 200 L ha-1 de calda; na herbigação foi usada lâmina de água de 4,72 mm, aplicada por simulador de irrigação. E. heterophylla foi mais suscetível ao fomesafen com 1 DAE. Neste estádio, a herbigação controlou-a melhor que a pulverização nas doses de 180 e 240 g ha-1. Na aplicação aos 7 DAE, geralmente a pulverização foi mais eficaz que a herbigação, mas o controle da planta daninha não foi satisfatório. Aplicado com 14 DAE, o herbicida, independentemente da dose e do método de aplicação, proporcionou controle pobre ou nenhum.Herbicide application via irrigation water (herbigation has been increasingly used in Brazil, mainly through center pivot. The aim of this study was to investigate the efficacy of fomesafen rates applied via overhead sprinkler irrigation for the control of Euphorbia heterophylla. A (4 x 3 x 2 + 3 factorial experiment was used consisting of: fomesafen rates (60, 120, 180, and 240 g ha-1, weed development stages (1, 7, and 14 days after emergence - DAE, application methods (spray and herbigation and checks that did

  5. Herança da resistência aos herbicidas inibidores da ALS em biótipos da planta daninha Euphorbia heterophylla Inheritance of ALS inhibitor resistance in Euphorbia heterophylla weed biotypes

    Directory of Open Access Journals (Sweden)

    L. Vargas

    2001-12-01

    Full Text Available Os herbicidas inibidores da ALS são os principais produtos aplicados para o controle da planta daninha amendoim-bravo (Euphorbia herterophylla em lavouras de soja; no entanto, já foram identificados biótipos desta planta daninha resistentes a estes herbicidas no Brasil. O objetivo desta pesquisa foi estudar a herança, o número de genes que conferem a resistência e o grau de resistência dos biótipos homozigotos e heterozigotos resistentes. Foram realizados cruzamentos recíprocos entre os genitores suscetíveis e resistentes para obtenção de sementes F1 e, posteriormente, realizaram-se os retrocruzamentos (RC com os genitores resistente (R e suscetível (S. Plantas F1 foram autofecundadas artificialmente para obtenção da geração F2. As plantas F1, F2, RCr e RCs e dos genitores foram tratadas com o herbicida imazethapyr (150 g ha-1. Para avaliar o grau de resistência, plantas F1 e os genitores resistente e suscetível foram tratados com as doses de imazethapyr de 0, 100, 200, 400, 800 e 1.600 g ha-1. As plantas F1 mostraram-se totalmente resistentes ao herbicida, demonstrando que a resistência é nuclear e dominante. As plantas F2 apresentaram alta probabilidade para segregação 3:1, indicando que a resistência é codificada por um gene dominante. A aplicação de doses de imazethapyr sobre as plantas F1 demonstrou que os biótipos homozigotos resistentes e os heterozigotos apresentam o mesmo grau de resistência para doses de até 1.600 g ha-1 deste herbicida. A resistência é codificada por um gene dominante nuclear com dominância completa.The ALS inhibitor herbicides are the main products applied to control Euphorbia heterophylla in the soybean crop; however, resistant biotypes to these herbicides have been identified in Brazil. This research aimed to study the inheritance, number of genes involved in the resistance and the degree of resistance of the homozygous and heterozygous resistant biotypes. Reciprocal crossings (RSs

  6. Privatiserung von Geschichte. Probleme einer differenzierten Aufarbeitung

    Directory of Open Access Journals (Sweden)

    Birthe Kundrus

    2000-11-01

    Full Text Available Ausgangspunkt der Untersuchung von Vera Neumann ist die These, daß im Krieg Erlebtes und Erlittenes in den Wiederaufbau- und Wirtschaftswunderjahren Westdeutschlands einem Thematisierungstabu unterlegen sei. Anhand von 50 Interviews, die in den 80er Jahren im Rahmen des von Lutz Niethammer geleiteten Projekts „Lebensgeschichte und Sozialgeschichte im Ruhrgebiet 1930–1960“ (LUSIR entstanden sind und die sie jetzt anhand der Tonbandprotokolle und Abschriften ein zweites Mal auswertet, möchte die Historikerin diese Verschüttungen aufspüren. Im Anschluß an Niethammers These der „Privatisierung von Geschichte“ will sie zeigen, daß seelische und körperliche Kriegsfolgen wie Deprivations- und Überlastungsgefühle, der Verlust von Angehörigen und Kriegsbeschädigungen „privatisiert“, d.h. an die Familien übertragen wurden. Dort seien dann in erster Linie die weiblichen Familienmitglieder mit der Versorgungs- und Pflegearbeit konfrontiert worden. An vier Fallbeispiele schließt sich eine detaillierte Auswertung des gesamten Interviewmaterials an. Diesen Teilen folgt ein Abschnitt zur staatlichen Kriegsopferversorgung in der frühen Bundesrepublik.

  7. An MRI Von Economo - Koskinas atlas.

    Science.gov (United States)

    Scholtens, Lianne H; de Reus, Marcel A; de Lange, Siemon C; Schmidt, Ruben; van den Heuvel, Martijn P

    2016-12-28

    The cerebral cortex displays substantial variation in cellular architecture, a regional patterning that has been of great interest to anatomists for centuries. In 1925, Constantin von Economo and George Koskinas published a detailed atlas of the human cerebral cortex, describing a cytoarchitectonic division of the cortical mantle into over 40 distinct areas. Von Economo and Koskinas accompanied their seminal work with large photomicrographic plates of their histological slides, together with tables containing for each described region detailed morphological layer-specific information on neuronal count, neuron size and thickness of the cortical mantle. Here, we aimed to make this legacy data accessible and relatable to in vivo neuroimaging data by constructing a digital Von Economo - Koskinas atlas compatible with the widely used FreeSurfer software suite. In this technical note we describe the procedures used for manual segmentation of the Von Economo - Koskinas atlas onto individual T1 scans and the subsequent construction of the digital atlas. We provide the files needed to run the atlas on new FreeSurfer data, together with some simple code of how to apply the atlas to T1 scans within the FreeSurfer software suite. The digital Von Economo - Koskinas atlas is easily applicable to modern day anatomical MRI data and is made publicly available online. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Doença de von Willebrand e anestesia Enfermedad de von Willebrand y anestesia Von Willebrand's disease and anesthesia

    Directory of Open Access Journals (Sweden)

    Fabiano Timbó Barbosa

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A doença de von Willebrand ocorre devido à mutação no cromossomo 12 e é caracterizada por deficiência qualitativa ou quantitativa do fator de von Willebrand. A diversidade de mutações leva ao aparecimento das mais variadas manifestações clínicas possibilitando a divisão dos pacientes em vários tipos e subtipos clínicos. A coagulopatia se manifesta basicamente através da disfunção plaquetária associada à diminuição dos níveis séricos do fator VIII coagulante. O objetivo dessa revisão foi mostrar os cuidados relacionados aos pacientes portadores da doença de von Willebrand durante o período perioperatório. CONTEÚDO: Foram definidas as características da doença de von Willebrand quanto à fisiopatologia, à classificação, ao diagnóstico laboratorial, ao tratamento atual e aos cuidados com o manuseio do paciente no período perioperatório. CONCLUSÕES: A doença de von Willebrand é o distúrbio hemorrágico hereditário mais comum, porém ela é subdiagnosticada pela complexidade da própria doença. A correta classificação do paciente, o uso apropriado da desmopressina e a transfusão do fator de von Willebrand são medidas fundamentais para a realização do procedimento anestésico bem-sucedido.JUSTIFICATIVA Y OBJETIVOS: La enfermedad de von Willebrand ocurre debido a la mutación en el cromosoma 12 y se caracteriza por la deficiencia cualitativa o cuantitativa del factor de von Willebrand. La diversidad de mutaciones conlleva al aparecimiento de las más variadas manifestaciones clínicas posibilitando la división de los pacientes en varios tipos y subtipos clínicos. La coagulopatía se manifiesta básicamente a través de la disfunción plaquetaria asociada con la disminución de los niveles séricos del factor VIII coagulante. El objetivo de esa revisión fue mostrar los cuidados relacionados con las pacientes portadoras de la enfermedad de von Willebrand durante el per

  9. Von der Universitätsbibliothek Regensburg zum Bayerischen Bibliotheksverbund

    OpenAIRE

    Frankenberger, Rudolf

    1989-01-01

    Von der Universitätsbibliothek Regensburg zum Bayerischen Bibliotheksverbund : d. Entwicklung d. Bayer. Bibliotheksverbundes. - In: Bibliothekslandschaft Bayern : Festschr. für Max Pauer zum 65. Geburtstag / hrsg. von Paul Niewalda. - Wiesbaden : Harrassowitz, 1989. - S. 84-96

  10. Kerttu Wagner. Die historischen romane von Jaan Kross / Wolfgang Drechsler

    Index Scriptorium Estoniae

    Drechsler, Wolfgang, 1963-

    2001-01-01

    Arvustus: Wagner, Kerttu. Die historischen Romane von Jaan Kross : am Beispiel einer Untersuchung der deutschen und englischen Übersetzungen von "Professor Martensi ärasõit" (1984). Frankfurt am Main [etc.] : P. Lang, 2001.

  11. Gemeinsam hilfreich oder einsam lästig? Beurteilung von praktikumsbegleitenden Weblogs von angehenden Lehrpersonen

    Directory of Open Access Journals (Sweden)

    Nives Egger

    2017-02-01

    Full Text Available Weblogs werden an Hochschulen vermehrt zur Unterstützung von Lern- und Reflexionsprozessen eingesetzt, in der Lehrer/innenbildung auch zunehmend während der berufspraktischen Ausbildung. Die Studierenden beurteilen den Einsatz von Weblogs jedoch unterschiedlich. Dabei ist wenig bekannt, welchen Einfluss die Vergabe und das Erhalten von Peerfeedback auf den Beurteilungsprozess von praktikumsbegleitenden Weblogs sowie auf den Umfang von Blogpostings haben. Im folgenden Beitrag wird dieser Frage mittels einer Befragung von 74 angehenden Lehrpersonen nachgegangen, die praktikumsbegleitende Weblogs mit oder ohne Peerfeedback nutzten, um über herausfordernde Ereignisse im Praktikum zu reflektieren. Die Ergebnisse zeigen, dass Studierende, die Peerfeedback erhielten und andere Blogbeiträge kommentierten, den Weblogeinsatz nützlicher einschätzen sowie eine höhere Motivation und positivere Einstellung gegenüber den Einsatz von Weblogs aufweisen als Studierende, die ohne Peerfeedback bloggen. Keinen Einfluss hat Peerfeedback auf den Umfang der Blogbeiträge und auf die dafür aufgewendete Zeit.

  12. Polylaktidbeschichtung zur antithrombogenen Ausrüstung von Biomaterialien

    OpenAIRE

    Mebus, Siegrun

    2007-01-01

    In der Klinik etablierte Biomaterialien wurden mit einer Polylaktidbeschichtung und eingearbeiteten Antikoagulanzien ausgerüstet. Die mit einem in-vitro-Modell erarbeiteten Daten zeigen, daß der Arzneistoffträger innerhalb von 90 Tagen nicht abgebaut wurde. Die Freisetzung der Arzneistoffe erfolgte abhängig von deren Konzentration und dem Mischungsverhältnis von Iloprost und Hirudin. Iloprost beeinflußt die Freisetzungsrate von PEG-Hirudin bzw. r-Hirudin. Es konnte mit mikrobiologischen Metho...

  13. Nutzung der Eisenkorrosion zur Entfernung von Arsen aus Trinkwasser

    OpenAIRE

    Karschunke, Karsten

    2005-01-01

    In dieser Arbeit werden experimentelle Untersuchungen zur Nutzung von Eisenkorrosionsprozessen zur Entfernung von Arsen aus Trinkwasser vorgestellt. Auch in geringen Konzentrationen stellt diese Verunreinigung auf Grund der krebserregenden Wirkung von Arsen langfristig eine Gefahr für die menschliche Gesundheit dar. Verschiedene Entfernungsmethoden sind bekannt und in der Praxis der Trinkwasseraufbereitung bewährt, beispielsweise Flockungsverfahren unter Einsatz von Eisensalzen oder die Adsor...

  14. Liouville-von Neumann molecular dynamics.

    Science.gov (United States)

    Jakowski, Jacek; Morokuma, Keiji

    2009-06-14

    We present a novel first principles molecular dynamics scheme, called Liouville-von Neumann molecular dynamics, based on Liouville-von Neumann equation for density matrices propagation and Magnus expansion of the time-evolution operator. The scheme combines formally accurate quantum propagation of electrons represented via density matrices and a classical propagation of nuclei. The method requires a few iterations per each time step where the Fock operator is formed and von Neumann equation is integrated. The algorithm (a) is free of constraint and fictitious parameters, (b) avoids diagonalization of the Fock operator, and (c) can be used in the case of fractional occupation as in metallic systems. The algorithm is very stable, and has a very good conservation of energy even in cases when a good quality conventional Born-Oppenheimer molecular dynamics trajectories is difficult to obtain. Test simulations include initial phase of fullerene formation from gaseous C(2) and retinal system.

  15. Gasification of liquid manure; Vergasung von Guelle

    Energy Technology Data Exchange (ETDEWEB)

    Gudenau, H.W.; Hoberg, H.; Hirsch, U. [Technische Hochschule Aachen (Germany). Inst. fuer Eisenhuettenkunde

    1996-12-31

    The potential of thermal use of liquid manure is investigated. It is recommended to separate the liquid and solid fraction. While the liquid fraction can be used as fertilizer, the solid fraction can be used for generating a fuel gas for combined heat and power generation. (orig) [Deutsch] Die Untersuchungen haben ergeben, dass in der thermischen Verwertung von Guelle ein bisher nur wenig genutztes Potential vorliegt. Die zum Anbau von Getreide notwendige Duengung kann durch Separation von Guelle in Fest- und Duennfraktion effektiver und kostenguenstiger durchgefuehrt werden. Der Naehrstoffgehalt des Guellefeststoffs sollte durch thermische Aufbereitung aufkonzentriert werden, so dass eine Vermarktung auch mit laengeren Transpoertwegen darstellbar ist. Die bei der thermischen Behandlung gewonnene Waerme kann prozessintern genutzt und ueberschuessige Waerme an Abnehmer in der naeheren Umgebung geliefert werden. Genauso besteht die Moeglichkeit, ein Brenngas zu erzeugen und die Energie mit Kraft-Waerme-Kopplung zu nutzen. (orig)

  16. Long-term dynamics of leafy spurge (Euphorbia esula) and its biocontrol agent, flea beetles in the genus Aphthona

    Science.gov (United States)

    Larson, Diane L.; Grace, James B.; Larson, Jennifer L.

    2008-01-01

    Three flea beetle species (Aphthona spp.), first introduced into North America in 1988, have come to be regarded as effective biological control organisms for leafy spurge (Euphorbia esula). The black flea beetles (Aphthona lacertosa and A. czwalinae) in particular have been shown to cause reductions in leafy spurge stem counts in the northern Great Plains, while the brown flea beetle (A. nigriscutis) has persisted and spread, but has not been found to be as effective at controlling leafy spurge. The ability of black flea beetles to control leafy spurge in any given year, however, has been found to vary. To better understand the long-term effects of flea beetle herbivory on leafy spurge, we monitored stem counts of leafy spurge and numbers of black and brown flea beetles at three sites on two National Wildlife Refuges in east-central North Dakota, USA, from 1998 to 2006. Brown flea beetle numbers were observed to be negligible on these sites. Over the 9 years of the study, black flea beetles were seen to spread over the three study sites and leafy spurge stem counts declined substantially on two of the three sites. Even at low densities of spurge, black flea beetle populations persisted, a necessary prerequisite for long-term control. We used structural equation models (SEM) to assess the yearly effects of black flea beetles, soil texture, and refuge site on leafy spurge stem counts over this time period. We then used equations developed from the SEM analysis to explore flea beetle–leafy spurge dynamics over time, after controlling for soil texture and refuge. Yearly effect strength of black flea beetles on leafy spurge was found to be modest, largely owing to substantial spatial variability in control. However, simulation results based on prediction coefficients revealed leafy spurge to be highly responsive to increases in flea beetle populations on average.

  17. Mosquito larvicidal and pupicidal activity of Euphorbia hirta Linn. (Family: Euphorbiaceae) and Bacillus sphaericus against Anopheles stephensi Liston. (Diptera: Culicidae).

    Science.gov (United States)

    Panneerselvam, C; Murugan, K; Kovendan, K; Kumar, P Mahesh; Subramaniam, J

    2013-02-01

    To explore the larvicidal and pupicidal activity of Euphorbia hirta (E. hirta) leaf extract and Bacillus sphaericus (B. sphaericus) against the malarial vector, Anopheles stephensi (An. stephensi). The larvicidal and pupicidal activity was assayed against An. stephensi at various concentrations ranging from (75-375 ppm) under the laboratory as well as field conditions. The LC(50) and LC(90) value of the E. hirta leaf extract was determined by probit analysis. The plant extract showed larvicidal effects after 24 h of exposure; however, the highest larval mortality was found in the methanol extract of E. hirta against the first to fourth instars larvae and pupae of values LC(50)= 137.40, 172.65, 217.81, 269.37 and 332.39 ppm; B. sphaericus against the first to fourth instars larvae and pupae of values LC(50)= 44.29, 55.83, 68.51, 82.19 and 95.55 ppm, respectively. Moreover, combined treatment of values of LC(50)= 79.13, 80.42, 86.01, 93.00 and 98.12 ppm, respectively. No mortality was observed in the control. These results suggest methanol leaf extracts of E. hirta and B. sphaericus have potential to be used as an ideal eco-friendly approach for the control of the malarial vector, An. stephensi as target species of vector control programs. This study provides the first report on the combined mosquito larvicidal and pupicidal activity of this plant crude extract and bacterial toxin against An. stephensi mosquitoes. Copyright © 2013 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  18. Bioactivity of latex from Euphorbia splendens var. hislopii (Euphorbiaceae) on post-embryonic development of Megaselia scalaris (Phoridae).

    Science.gov (United States)

    Mello, Renata da Silva; Ferreira, Aline Roberta da Silva; Queiroz, Margareth Maria de Carvalho

    2010-08-27

    Larvae of Megaselia scalaris (Loew, 1866) feed on a wide range of decomposing organic matter and present a great importance to public health. This study evaluated the effect of crude latex extract from Euphorbia splendens var. hislopii (Euphorbiaceae) on post-embryonic development time of M. scalaris under laboratory conditions. The latex was used in its crude lyophilized form, dissolved in distilled water and tested in concentrations of 5 microg/mL, 10 microg/mL and 20 microg/mL. The latex was applied with the aid of an automatic pipette (1 microL/larva) on the newly-hatched larvae. Each group (the three concentrations of latex and the control group) was composed of 50 larvae and fed with 25mg of decomposing horse flesh. The experiment was made in quadruplicate. The observations were recorded daily. The data were submitted to analysis of variance (ANOVA) and Tukey's post hoc-test with a 5% significance level. The post-embryonic development time for all stages (larval, pupal and newly-hatched larvae to adult) tested with all three latex concentrations was significantly shorter than for the control group, but without any significant difference among the different concentrations. The more sensitive stages to the substance were pupal and newly-hatched larvae to adult. The viability was less than 51.5% in the three concentrations of latex in these stages and they were lower than for the control group (67.4% for pupal stage and 64% for newly-hatched larvae to adult). Therefore, it is likely that this substance has influence on the development and viability of these flies and can become a promising agent for insect pest management. (c) 2010 Elsevier B.V. All rights reserved.

  19. [Anja Wilhelmi. Lebensweltlen von Frauen der deutschen Oberschicht im Baltikum (1800-1939). Eine Untersuchung anhand von Autobiographien] / Alexander Ewig

    Index Scriptorium Estoniae

    Ewig, Alexander, 1980-

    2011-01-01

    Arvustus: Wilhelmi, Anja. Lebenswelten von Frauen der deutschen Oberschicht im Baltikum (1800-1939). Eine Untersuchung anhand von Autobiographien. (Veröffentlichungen des Nordost-Instituts, 10.) (Wiesbaden : HArrassowitz 2008)

  20. Wachstum und Aufbau von Spongomorpha aeruginosa (Chlorophyta, Acrosiphoniales)

    NARCIS (Netherlands)

    Kornmann, Peter

    1967-01-01

    In zahlreichen Arbeiten dienten Algen als Objekte für das Studium von Regenerationsvorgängen und Erscheinungen der Polarität. Dagegen ist — von Chara abgesehen — über das normale Wachstum, den zeitlichen Ablauf von Teilung und Streckung der Zellen und die Entstehungsgeschichte des typischen Thallus

  1. Modellierung von Dienstleistungen mittels Business Service Blueprinting Modeling

    OpenAIRE

    Meis, Jochen; Menschner, Philipp; Leimeister, Jan Marco

    2010-01-01

    Der Beitrag stellt mit Business Service Blueprint Modeling (BSBM) einen konzeptionellen Ansatz zur Modellierung von Dienstleistungen vor, der ein systematisches und standardisiertes Vorgehen zur Modellierung von Dienstleistungen mit Kundeninteraktion anstrebt. BSBM verwendet hierzu die Business Process Modeling Notation (BPMN) in einem Service Blueprint (SB). Somit wird ein Modellierungskonzept geschaffen, das sowohl Kundeninteraktionspunkte berücksichtigt als auch von aktuellen Werkzeugen un...

  2. Spectral theory and quotients in Von Neumann algebras | West ...

    African Journals Online (AJOL)

    In this note we consider to what extent the functional calculus and the spectral theory in von Neumann algebras are preserved by the taking of quotients relative to two-sided ideals of the von Neumann algebra. Keywords:von Neumann algebra, functional calculus, spectral theory, quotient algebras. Quaestiones ...

  3. Market Timing und Finanzierungsentscheidungen: Unterscheidet sich Europa von den USA?

    NARCIS (Netherlands)

    Sautner, Z.; Spranger, J..

    2009-01-01

    Seit der Arbeit von Baker/Wurgler (2002) hat sich die Market-Timing-Theorie als alternative Kapitalstrukturtheorie etabliert. Sie impliziert, dass die Kapitalstruktur von Unternehmen das kumulierte Ergebnis von Versuchen des Equity Market Timing ist. Im Rahmen dieser Studie wird untersucht,

  4. Bewertung von Fahrzeuggeräuschen

    Science.gov (United States)

    Genuit, Klaus; Schulte-Fortkamp, Brigitte; Fiebig, André; Haverkamp, Michael

    Bei der Wahrnehmung und Beurteilung eines Automobils sind unzählige Merkmale und Eigenschaften von Bedeutung. Dabei können Merkmale objektiv-technisch beschrieben werden, wie Angaben zur Motorisierung, Höchstgeschwindigkeit, Drehmoment, zulässige Zuladung, Verbrauch usw. Daneben sind weitere Eigenschaften von Bedeutung, die sich einer einfachen objektiv-technischen Beschreibung entziehen. Hier sind Begriffe zu nennen, wie Sicherheit, allgemeine Qualitätsanmutung, Design, Ergonomie, Komfort, Haptik, Fahrdynamik, Zuverlässigkeit, die deutlich schwieriger objektiv erfassbar und beschreibbar sind (Abb. 4.1).

  5. [Von Recklinghausen disease and hepatic neurofibromatosis].

    Science.gov (United States)

    Guzman Toro, F; Hinestroza, D; Colmenares, D

    1995-01-01

    Von Recklinghausen's neurofibromatosis is one of the most common autosomal dominant disease with an estimated frecuency of 1:3000 live births. Characteristic lesions include cafe-au-lait spots and neurofibromas following the path of peripheral nerves. Liver involvement by neurofibromatosis is rare and very few cases have been reported. We present a case of a young man with Von Recklinhausen's disease and hepatic neurofibromatosis with multiple caf-au-lait spots, cutaneous neurofibromas, short stature and osseous lesions and compare the clinical, radiological, surgical and anatomopathological findings with others describe previously in the literature.

  6. Zur Aktivierung des Verbundtragverhaltens von Glaslaminaten

    OpenAIRE

    Sastré-Terrasa, Johannes (Hanno)

    2007-01-01

    Für jedes konstruktiv planerische Handeln ist ein fundiertes Wissen über die Baustoffe primäre Voraussetzung. Das trifft für Glas, auf Grund der Komplexität des Materialverhaltens, im besonderen Maße zu. Diese Arbeit beschäftigt sich deshalb zunächst mit dem Werkstoff Glas, den Grundlagen zum schadensfreien Fügen von Glas sowie dem Verhalten seiner Fügepartner. Die wichtigste Methode, das Kleben von Glas, wird im Wesentlichen durch die viskoelastischen und temperaturabhängig...

  7. Erwachsenenbildung im Spannungsfeld von Wissenschaft, Politik und Praxis: Heide von Felden, Christiane Hof und Sabine Schmidt-Lauff (Hrsg.). [Rezension

    OpenAIRE

    Filla, Wilhelm

    2016-01-01

    Rezension von: Felden, Heide von/Hof, Christiane/Schmidt-Lauff, Sabine (Hrsg.) (2013): Erwachsenenbildung im Spannungsfeld von Wissenschaft, Politik und Praxis. Dokumentation der Jahrestagung der Sektion Erwachsenenbildung der Deutschen Gesellschaft für Erziehungswissenschaften vom 27. bis 29. September 2012. Baltmannsweiler: Schneider Verlag Hohengehren.

  8. Die Verteilung und Eigenschaften von Bodenformen in der Deutschen Bucht, eine Rekonstruktion der Karten von Ulrich (1973)

    DEFF Research Database (Denmark)

    Winter, Christian; Lefebvre, Alice; Benninghoff, Markus

    2015-01-01

    Entstehung, Gestalt und Dynamik von Bodenformen in vergleichsweise kleinen Untersuchungsgebieten ist die Arbeit von ULRICH (1973) über die Verteilung von Bodenformen in der Deutschen Bucht bis heute die einzige verfügbare zusammenhängende Darstellung für die deutsche Nordseeküste. Die analogen Karten und die...

  9. An Ingenol Derived from Euphorbia kansui Induces Hepatocyte Cytotoxicity by Triggering G0/G1 Cell Cycle Arrest and Regulating the Mitochondrial Apoptosis Pathway in Vitro

    Directory of Open Access Journals (Sweden)

    Xiaojing Yan

    2016-06-01

    Full Text Available Natural product lingenol, a purified diterpenoid compound derived from the root of Euphorbia kansui, exerts serious hepatotoxicity; however, the molecular mechanisms remain to be defined. In the present study, cell counting Kit-8 (CCK-8, inverted phase contrast microscope and flow cytometry were used to demonstrate that lingenol significantly inhibited L-O2 cells proliferation, and induced cell cycle arrest and apoptosis. Moreover, the results investigated that lingenol markedly disrupted mitochondrial functions by high content screening (HCS. In addition, the up-regulation of cytochrome c, AIF and Apaf-1 and activation of caspases were found in L-O2 cells detected by Western blotting and ELISA assay, which was required for lingenol activation of cytochrome c-mediated caspase cascades and AIF-mediated DNA damage. Mechanistic investigations revealed that lingenol significantly down-regulated the Bcl-2/Bax ratio and enhanced the reactive oxygen species (ROS in L-O2 cells. These data collectively indicated that lingenol modulation of ROS and Bcl-2/Bax ratio led to cell cycle arrest and mitochondrial-mediated apoptosis in L-O2 cells in vitro. All of these results will be helpful to reveal the hepatotoxicity mechanism of Euphorbia kansui and to effectively guide safer and better clinical application of this herb.

  10. Development of a Matrix Solid-Phase Dispersion Extraction Combined with UPLC/Q-TOF-MS for Determination of Phenolics and Terpenoids from the Euphorbia fischeriana.

    Science.gov (United States)

    Li, Wenjing; Lin, Yu; Wang, Yuchun; Hong, Bo

    2017-09-11

    A method based on a simplified extraction by matrix solid phase dispersion (MSPD) followed by ultra-performance liquid chromatography coupled with the quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) determination is validated for analysis of two phenolics and three terpenoids in Euphorbia fischeriana. The optimized experimental parameters of MSPD including dispersing sorbent (silica gel), ratio of sample to dispersing sorbent (1:2), elution solvent (water-ethanol: 30-70) and volume of the elution solvent (10 mL) were examined and set down. The highest extraction yields of chromatogram information and the five compounds were obtained under the optimized conditions. A total of 25 constituents have been identified and five components have been quantified from Euphorbia fischeriana. A linear relationship (r² ≥ 0.9964) between the concentrations and the peak areas of the mixed standard substances were revealed. The average recovery was between 92.4% and 103.2% with RSD values less than 3.45% (n = 5). The extraction yields of two phenolics and three terpenoids obtained by the MSPD were higher than those of traditional reflux and sonication extraction with reduced requirement on sample, solvent and time. In addition, the optimized method will be applied for analyzing terpenoids in other Chinese herbal medicine samples.

  11. Coagulation And Hemagglutination Properties Of The Crude Extract Derived From The Leaves Of Euphorbia Hirta L. Tridax Procumbens L. And Vernonia Cinerea L Less

    Directory of Open Access Journals (Sweden)

    Romeo C. Ongpoy

    2015-08-01

    Full Text Available This study aims to investigate the potential of selected wild grasses from the Philippines as coagulant and typing sera. To do this Euphorbia hirta L. Tridax procumbens L. and Vernonia cinerea L Less aqueous infusions were each subjected to blood components from healthy individuals. The plasma part of the blood was used to test for coagulation where Plasma Clotting Time PCT and Factor VIII screening test were the procedures used to test the different leaf extracts. On the other hand the Packed Red Blood Cell part of the blood was used to test for hemagglutination where microscopic and macroscopic evaluations were the procedures used to test the different leaf extracts against the blood groups from the ABO system. About this study it was found out that all the wild grasses did not give a comparable coagulation to the commercially available positive control which is Calcium Chloride while Euphorbia hirta L. gave a positive hemagglutination to Type A and Type B cells Tridax procumbens L. gave a positive hemagglutination to Type A cell and Vernonia cinerea L Less gave a positive hemagglutination to Type B cells both in macroscopic and microscopic evaluations. The results show that all the wild grasses tested may not be used as a coagulant but all of them may have a potential as a typing sera.

  12. Der Briefwechsel zwischen Alexander von Humboldt und Karl Ernst von Baer

    Directory of Open Access Journals (Sweden)

    Thomas Schmuck

    2012-10-01

    Full Text Available Zusammenfassung Der kurze, nicht vollständig erhaltene Briefwechsel zwischen Alexander von Humboldt und Karl Ernst von Baer behandelt sehr verschiedene Themen: Politik, Kriegsgefahr, den Wissenschaftsbetrieb, Auszeichnungen und Tagungen, Embryologie und Cholera. Gemeinsam mit Briefen und Reden ergibt sich dabei ein differenziertes Bild der Beurteilung der beiden Wissenschaftler durch den jeweils anderen. Während Baer sich als Bewunderer Humboldts erweist, erscheint umgekehrt Humboldts Einschätzung Baers als ambivalent. Abstract The short, not completely preserved correspondence between Alexander von Humboldt and Karl Ernst von Baer deals with a wide range of subjects: politics and the danger of war, academic activities, scientific awards and conferences, aspects of embryology and the cholera. Letters to third persons and speeches, together with the correspondence between Humboldt and Baer show a differentiated pattern of mutual appraisal: While Baer always remained an admirer of the elder naturalist, Humboldt’s estimation was characterized by ambivalence.

  13. Interpenetration bei Parsons und Luhmann : Von der Integration zur Produktion von Unordnung

    OpenAIRE

    Künzler, Jan

    2010-01-01

    Talcott Parsons hatte den Interpenetrationsbegriff eingeführt, um strukturelle Beziehungen zwischen verschiedenen System arten erfassen zu können. Niklas Luhmann übernimmt den Begriff von Parsons und benutzt ihn nach weitreichenden Revisionen v. a. dazu, das Verhältnis von psychischen und sozialen Systemen auf den Begriff zu bringen. In dieser Intersystembeziehung spielt Sprache eine entscheidende Rolle. Ein systemtheoretisches Sprachkonzept, das dieser Vermittlungsleistung Rechnung trägt, st...

  14. Dentinhaftung von Zementen. Der Haftverbund von Zementen mit Dentin in Kombination mit verschiedenen indirekten Restaurationsmaterialien

    OpenAIRE

    Peutzfeldt, Anne; Sahafi, Alireza; Flury, Simon

    2011-01-01

    Einleitung: Die Anzahl zahnärztlicher Zemente sowie Restaurationsmaterialien steigt stetig. Die richtige Zementwahl für einen zuverlässigen Haftverbund zwischen Restaurationsmaterial und Zahnsubstanz ist von Interesse für den Kliniker. Ziel der vorliegenden in vitro-Studie war es daher, den Dentinhaftverbund von verschiedenen Zementen in Kombination mit verschiedenen indirekten Restaurationsmaterialien zu untersuchen. Material und Methoden: Zylindrische Probekörper aus sechs Restaurations...

  15. Identifizierung von Mikrodomän-Proteinen und funktionelle Charakterisierung von Cholesterin im Golgi-Apparat

    OpenAIRE

    Stüven, Ernstpeter

    2002-01-01

    Mittels Detergenzextraktion von Golgimembranen bei 0°C mit anschließender Dichtegradientenzentrifugation wurden sphingolipid- und cholesterinreiche Mikrodomänen isoliert, die zehn Proteine entsprechend der Coomassiefärbung in der SDS-PAGE enthalten. Im Rahmen dieser Arbeit wurden die zwei bisher nicht charakterisierten Proteine mit Molekulargewichten von 72 und 56 kDa als Untereinheiten A und B der vakuolären ATPase identifiziert. Daneben konnte mit NAP-22 eine elfte Komponente identifiziert ...

  16. Der "Bindungsfragebogen" von Grau und der "Bielefelder Fragebogen zu Partnerschaftserwartungen" von Hoger und Buschkamper im Vergleich

    National Research Council Canada - National Science Library

    Ina Grau; Ulrich Clashausen; Diether Hoger

    2003-01-01

    ...". Das Bindungsmuster ergibt sich aus der speziellen anhand von Clusteranalysen ermittelten Konfiguration der Skalen. In Clusteranalysen mit dem BinFB wurden vier Cluster aufgefunden, mit dem BFPE funf Cluster. Wahrend vier der BFPE-Cluster recht gut mit den vier BinFB-Clustern ubereinstimmen, wird eine funfte Personengruppe vom BFPE als "vermeidend-offnungsbereit" und von BinFB als "sicher" klassifiziert. Beide Interprctationsmoglichkeiten werden unter besonderer Berucksichtigung der Skala "Zuwendungsbedurfn...

  17. Authentizität von Milch und Fisch – Erkennung von Bioprodukten im Labor

    OpenAIRE

    Molkentin, Joachim

    2008-01-01

    Die Nachfrage nach Bio-Lebensmitteln ist in Deutschland in den letzten Jahren stetig gestiegen. So erhöhte sich der Absatz von Bio-Trinkmilch in 2007 im Vergleich zum Vorjahr erneut um 34 %. Aufgrund sporadisch resultierender Lieferengpässe bei Bio-Milch aber auch der erheblichen Handelspreisdifferenz – wie z. B. insbesondere bei Bio-Lachs – besteht ein potenzielles Risiko der Falschdeklaration konventioneller Produkte als Bio-Ware. Zum Schutz von Verbrauchern wie auch Erzeugern werden dah...

  18. Die Rezeptionsgeschichte von Ulrich Schmidels Wahrhaftige Beschreibung von 1567 bis heute

    OpenAIRE

    Obermeier, Franz

    2001-01-01

    Schmidels Werk hat bisher nur in Ansätzen die ihm zustehende Würdigung als eines der wichtigsten Quellenwerke der frühen Kolonialzeit Südamerikas erfahren. Es stand lange Zeit im Schatten des bekannteren und auch literarisch ansprechenderen Reisebuchs von Hans Staden (Wahrhaftige Historia, Marburg 1557), dessen persönliche Schilderung seiner Gefangenschaft dem modernen Leser durch den geschickten Einsatz von narrativen Elementen entsprechend der heutigen Genretradition des persönlich gefasste...

  19. Analyse von Arbeitsplätzen auf halbautomatischen Pflanzmaschinen mit Hilfe von MTM (Methods Time Measurement)

    OpenAIRE

    Remmele, Edgar

    2017-01-01

    Mit Hilfe von MTM (Methods Time Measurement), einem System vorbestimmter Zeiten, werden Bewegungsstudien an drei verschiedenen halbautomatischen Pflanzmaschinen durchgeführt. Hauptunterscheidungsmerkmal der untersuchten Pflanzmaschinen ist die Methode der Übergabe der Pflanze von der Pflanzperson an die Pflanzmaschine. Analysiert wird der Arbeitsplatz der Pflanzmaschine ACCORD-Standard mit der Methode Klemmscheibe, PES-Beetpflanzer 1500/1900 mit der Methode Pflanzfinger und Lännen RT-2 mit de...

  20. Zur Entwicklung von Containerschiffsflotten : eine Paneldatenanalyse

    OpenAIRE

    Prinz, Alexander; Schulze, Peter M.

    2004-01-01

    Diese Arbeit untersucht die regional aggregierten Containerschiffsflotten der wichtigsten Wirtschaftsräume entlang der Hauptverkehrsrouten der Seeschifffahrt. Anhand einer Paneldatenanalyse mit festen Effekten werden die positive Abhängigkeit der Containerschifffahrt von Weltwirtschaft und Welthandel quantifiziert und erklärende Variablen für die Entwicklung der Containerschifffahrt identifiziert.

  1. Von Kalifornien nach Taxham / Katri Soe

    Index Scriptorium Estoniae

    Soe, Katri, 1971-

    2005-01-01

    Neljas osa magistritööst "Von Kalifornien nach Taxham: Formen und Strukturen der Kommunikation in Peter Handkes Romanen "Der kurze Brief zum langen Abschied" und "In einer dunklen Nacht ging ich aus meinem stillen Haus"" (Tartu, 2000. Juhendaja: Claus Sommerhage)

  2. Euler-Chelpin, Prof. Hans von

    Indian Academy of Sciences (India)

    Euler-Chelpin, Prof. Hans von. Nobel Laureate (Chemistry) - 1929. Date of birth: 15 February 1873. Date of death: 6 November 1964 ... Posted on 21 December 2017. ASTROPHYSICS: An Observational View of the Universe. Math Art and Design: MAD about Math, Math Education and Outreach. Math and Finance ...

  3. Ueberreste vorweltlicher Proboscidier von Java und Banka

    NARCIS (Netherlands)

    Martin, K.

    1884-01-01

    Junghuhn führte in seinem Werke über Java nur einen einzigen Wirbelthierrest, Carcharias megalodon, an (7, IV, pag. 97); es war ihm nicht gelungen bei seinem ersten Aufenthalte auf der Insel Reste von Säugethieren zu finden, so eifrig er auch darnach in den Höhlen des Tertiaergebirges suchte (7, IV,

  4. Alte und neue Scyphomedusen von Australien

    NARCIS (Netherlands)

    Stiasny, G.

    1926-01-01

    In einer Collection Coelenterata, von verschiedenen australischen Fundorten herrührend, die mir vom Direktor des Australian Museum in Sydney, Dr. Ch. Anderson, zur Untersuchung übersendet wurden, fanden sich auch einige Scyphomedusen, die in den australischen Gewässern bisher noch nicht nachgewiesen

  5. Eigenschaften von Gott. Eine quantitative Analyse

    Directory of Open Access Journals (Sweden)

    Thomas Benesch

    2016-12-01

    Full Text Available ENGLISH: A quantitative research on 32 pupils of an elementary school (third and fourth class was performed. The questions regarded to socio-demographic issues as well as so called opposition pairs for God. These opposition pairs include the semantic differential of the loving God combined with the selection of 27 opposition pairs which were derived from literature. The image of God has been developed due to a factor analysis with respect to human and divine properties. These characteristics are depending on the religious education of children as well as their habits of reading in the Holy Bible. DEUTSCH: Eine quantitative Erhebung von 32 Volksschulkindern einer 3. und 4. Klasse wurde einerseits mit erweiterten sozio-demographischen Fragen und gleichzeitig mit Gegensatzpaaren für Gott beschrieben. Die Gegensatzpaare beinhalteten das semantische Differential des liebenden Gottes zusammen mit einer Auswahl von 27 Gegensatzpaaren, die deduktiv aus der Literatur abgeleitet wurden. Das Gottesbild hat sich anhand einer Faktorenanalyse darin entwickelt, dass Gott einerseits mit menschlichen Attributen versehen wird und andererseits mit Eigenschaften von Gott. Diese Eigenschaften von Gott sind abhängig davon, ob die Kinder religiös erzogen werden und ob sie gerne die Heilige Schrift lesen.

  6. Active Von Willebrand Factor, thrombocytopenia and thrombosis

    NARCIS (Netherlands)

    Hulstein, J.J.J.

    2006-01-01

    Platelets and von Willebrand factor (VWF) are unable to interact in circulation. To induce an interaction, a conversion of VWF to a platelet-binding conformation is required. At higher shear stresses, the first step in thrombus formation is binding of VWF to the subendothelium. This results in

  7. Molecular mechanisms of von Willebrand Factor mechanoregulation

    NARCIS (Netherlands)

    Jakobi, A.J.|info:eu-repo/dai/nl/311489621

    2012-01-01

    Von Willebrand factor (VWF) multimers mediate primary adhesion and aggregation of platelets. The potency to recruit platelets critically depends on the size of VWF multimers, which is regulated by a feedback mechanism involving shear-induced unfolding of the A2 domain in VWF and cleavage by the

  8. Measurements and von Neumann projection/collapse

    Indian Academy of Sciences (India)

    unwanted superpositions of (system + apparatus)-states can be shown to be suppressed, leading eventually to the projection/collapse rule postulated in von Neumann's treatment of measurements [3]. In the next section, the measurement problem in quantum mechanics (QM) is recalled. In §3, some proposed improvements ...

  9. Guido von Pirquet: Austrian pioneer of astronautics

    Science.gov (United States)

    Sykora, F.

    1977-01-01

    The works of Guido von Pirquet, Austrian pioneer of rocketry, were assessed. Major emphasis was given to Pirquet's calculation of the route to Venus which in fact was followed by the first Russian rocket to Venus. Of interest also is Pirquet's valuable construction of a space station and his analysis of interstellar space flight.

  10. Soolopartiid Von Krahli katuse all / Kristi Eberhart

    Index Scriptorium Estoniae

    Eberhart, Kristi

    2007-01-01

    Von Krahli Teatri kolmest lavastusest: "Erki ja Tiina" (lavastaja Mart Kangro, tantsivad Erki Laur ja Tiina Tauraite), "Faust" (J. W. Goethe ainetel tekst ja lavastus Taavi Eelmaa, muusika ja laulud Chalice, osades Jarek Kasar ja Rein Pakk), "Hamletid" (William Shakespeare'i ainetel kontseptsiooni, lavastuse, koreograafia, kujunduse, valguse autor Sasha Pepeljajev, video- ja helikunstnik Taavet Jansen. Esitaja Juhan Ulfsak)

  11. De ziekte van Von Hippel-Lindau

    NARCIS (Netherlands)

    Los, M.; Links, T.P.; Lenders, J.W.M.; Voest, E.E.

    2000-01-01

    Von Hippel-Lindau disease (VHL) is an autosomal dominant inherited cancer syndrome. The disease was diagnosed in three patients: a 22-year-old woman who presented with decreased vision due to retinal angiomatosis and in whom a renal carcinoma was diagnosed five years later at a routine VHL analysis,

  12. Ueber eine Anomalie von Acromitus flagellatus (Stiasny)

    NARCIS (Netherlands)

    Stiasny, G.

    1934-01-01

    Bei erneuter Durchsicht des reichhaltigen Materiales von Acromitus flagellatus (Stiasny) in der Scyphomedusen-Sammlung des Rijksmuseum van Natuurlijke Historie in Leiden (vergl. meine Mitteilungen daruber, 1920, Uebersichtstabelle III und 1921, p. 131/136) fand ich ein Exemplar, das eine

  13. Laue, Prof. Max Theodor Felix von

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1954 Honorary. Laue, Prof. Max Theodor Felix von. Nobel Laureate (Physics) - 1914. Date of birth: 9 October 1897. Date of death: 24 April 1960. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the ...

  14. Ueber zwei neue Vogelarten von Java

    NARCIS (Netherlands)

    Finsch, O.

    1902-01-01

    Die beiden nachstehend beschriebenen Vögel wurden mir von Herrn Max Bartels als muthmasslich neu zugesandt. Die genaue Untersuchung hat dies bestätigt. Ich freue mich daher eine der Arten zu Ehren des Entdeckers benennen zu können. Seit einigen Jahren als Leiter der Plantage Pangerango bei Pasir

  15. Classical diagnostic radiological features of Von Recklinghausen's ...

    African Journals Online (AJOL)

    Neurofibromatosis type 1(NF-1, Von Recklinghausen disease or peripheral NF) is a rare autosomal dominant disorder with varied clinical manifestations involving the skin, nerves and bones. It is the most common of the neurocutaneous syndromes, with variable pathological and clinical expression. Approximately half of all ...

  16. Joint bleeding in von Willebrand disease

    NARCIS (Netherlands)

    Galen, K.P.M. van

    2017-01-01

    Von Willebrand disease (VWD) is the most common inherited bleeding disorder occurring in approximately 1/100 people. Until now, joint bleeds did not get much attention in clinical research on VWD, since mucocutaneous bleeding is predominant. However, recurrent joint bleeds lead to arthropathy, the

  17. Das Druckprofil von Sportkompressionsstrümpfen.

    Science.gov (United States)

    Reich-Schupke, Stefanie; Surhoff, Stefan; Stücker, Markus

    2016-05-01

    Zunehmend werden Sportkompressionsstrümpfe (SKS) eingesetzt, doch fehlt eine Norm in Analogie zu medizinischen Kompressionsstrümpfen (MKS). Ziel dieser Pilotstudie war der Vergleich der Druckprofile von fünf SKS ex vivo und in vivo miteinander sowie mit MKS-Normen. CEP Running-Progressive-Socks, Falke Running--Energizing, Sigvaris Performance, X-Socks Speed-Metal-Energizer und 2XU Compression--Race-Socks wurden an zehn Leistungssportlern (standardisiert in vivo, Kikuhime--Sensor) sowie im Hohenstein Institut (ex vivo) hinsichtlich ihres Druckprofils getestet. Die Ex-vivo-Messungen im Fesselbereich von CEP (25,6 mmHg) und 2XU (23,2 mmHg) entsprachen der deutschen MKS-Klasse 2, von Sigvaris-SKS (20,8 mmHg) der deutschen MKS-Klasse 1. Die übrigen SKS lagen darunter. Die ermittelten Druckprofile differierten stark und entsprachen nicht der MKS-Norm. Die In-vivo-Messungen zeigten für drei SKS (2XU, CEP, Sigvaris) durchschnittlich einen höheren Anpressdruck als die SKS von Falke und X-Socks. Alle SKS lagen in vivo jedoch unter der deutschen MKS-Klasse 1. Kein SKS bot den für MKS geforderten Druckabfall vom Messpunkt B nach D. Die in vivo und ex vivo ermittelten SKS-Druckprofile zeigten heterogene Ergebnisse und folgten kaum den MKS-Anforderungen. Entsprechend sind auch die klinisch-praktischen Effekte von SKS nicht vergleichbar. Wünschenswert wäre eine SKS-Klassifikation, die erlaubt, Produkte einzuordnen, zu vergleichen und nach konkreten Vorlieben und Bedürfnissen (hoher vs. geringer Druck, progressiver vs. degressiver Gradient) auszuwählen. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  18. Green mediated synthesis and characterization of ZnO nanoparticles using Euphorbia Jatropa latex as reducing agent

    Directory of Open Access Journals (Sweden)

    M.S. Geetha

    2016-09-01

    Full Text Available Presently the progress of green chemistry in the synthesis of nanoparticles with the use of plants has engrossed a great attention. This study reports the synthesis of ZnO using latex of Euphorbia Jatropa as reducing agent. As prepared product was characterized by powder X-ray diffractometer (PXRD, Fourier transform infra-red spectroscopy (FTIR, scanning electron microscopy–energy dispersive spectroscopy (SEM–EDS, transmission electron microscopy (TEM, X-ray photo electron spectroscopy (XPS, Rietveld refinement, UV–Visible spectroscopy and photoluminescence (PL. The concentration of plant latex plays an important role in controlling the size of the particle and its morphology. PXRD graphs showed the well crystallisation of the particles. The average particle size was calculated using Scherrer equation and advanced Williamson Hall (WH plots. The average particle size was around 15 nm. This result was also supported by SEM and TEM analyses. FTIR shows the characteristic peak of ZnO at 435 cm−1. SEM and TEM micrographs show that the particles were almost hexagonal in nature. EDS of SEM analysis confirmed that the elements are only Zn and O. EDS confirmed purity of ZnO. Atomic states were confirmed by XPS results. Crystal parameters were determined using Rietveld refinement. From UV–Visible spectra average energy gap was calculated which is ∼3.63 eV. PL studies showed UV emission peak at 392 nm and broad band visible emission centred in the range 500–600 nm. The Commission International de I'Eclairage and colour correlated temperature coordinates were estimated for ZnO prepared using 2 ml, 4 ml and 6 ml Jatropa latex. The results indicate that the phosphor may be suitable for white light emitting diode (WLED. The study fruitfully reveals simple, fast, economical and eco friendly method of synthesis of multifunctional ZnO nanoparticles (Nps.

  19. Seletividade de coroa-de-cristo (Euphorbia splendens a diferentes classes de herbicidas para manejo de plantas daninhas em jardinagem.

    Directory of Open Access Journals (Sweden)

    Cleber D. de G. Maciel

    2005-06-01

    Full Text Available Com objetivo de avaliar a seletividade da coroa-de-cristo (Euphorbia splendes para diferentes classes de herbicidas, três experimentos foram realizados, em condições de campo, na Fazenda Modelo da ESAPP/SP (2001/2002. Os tratamentos do Experimento 1 foram (em e.a. ou i.a.: glyphosate (1,44 kg.ha-1; sulfosate (1,44kg.ha-1; amônio-glufosinato (0,48 kg.ha-1; paraquat (0,60 kg.ha-1; glyphosate + flumioxazin (1,44 + 0,06 kg.ha-1; glyphosate + carfentrazone-ethyl (1,44 + 0,06 kg.ha-1 e testemunha. No Experimento 2:carfentrazone-ethyl (0,12 kg.ha-1; 2,4-D (1,30 kg.ha-1; isoxaflutole (0,06 kg.ha-1; nicosulfuron (0,06 kg.ha-1; metsulfuron-methyl (0,0024 kg.ha-1; lactofen (0,180 kg.ha-1; chlorimuron-ethyl (0,02 kg.ha-1; bentazon (1,25 kg.ha-1 e testemunha. No Experimento 3 foram testados: fluazifop-p-butyl (0,25 kg.ha-1; sethoxydim (1,25 kg.ha-1; haloxyfop-methyl (0,06 kg.ha-1; clethodim + fenoxaprop-p-ethyl (0,11 kg.ha-1; quizalofop-p-ethyl (0,10 kg.ha-1; clethodim (0,12 kg.ha-1; propaquizafop (0,12 kg.ha-1; tepraloxydim (0,40 kg.ha-1; butroxydim (0,10 kg.ha-1 e testemunha. No Experimento 1, nenhum tratamento foi seletivo, causando danos visíveis de fitointoxicação a partir dos 7 dias após aplicação. No Experimento 2, apenas o metsulfuron-methyl apresentou seletividade à coroa-de-cristo, para as folhas e inflorescências; sendo o isoxaflutole, nicosulfuron, chlorimuron-ethyl e bentazon impróprios apenas no que diz respeito à preservação de flores. No Experimento 3, todos os tratamentos indicaram seletividade à coroa-de-cristo, observando-se apenas injúrias às flores para os herbicidas fluazifop-p-butil e sethoxydim e propaquizafop.

  20. Resistência de biótipos de Euphorbia heterophylla l. Aos herbicidas inibidores da enzima ALS utilizados na cultura de soja Resistance of Euphorbia heterophylla l. Biotypes to ALS enzyme inhibitor herbicides used in soybean crop

    Directory of Open Access Journals (Sweden)

    GERSON AUGUSTO GELMINI

    2001-01-01

    Full Text Available Os herbicidas constituem-se na principal medida de controle de plantas daninhas na cultura de soja; no entanto, a pressão de seleção causada pelo uso contínuo de produtos com o mesmo mecanismo de ação pode provocar a seleção de biótipos resistentes, como ocorreu com Euphorbia heterophylla L., que se mostrou resistente aos herbicidas inibidores da enzima acetolactato sintase (ALS em áreas dos Estados do Paraná e Rio Grande do Sul. Para comprovar possíveis novos casos, bem como alternativas para prevenção e manejo, coletaram-se sementes de plantas de E. heterophylla L., na região de Assis (SP, que sobreviveram a tratamentos, em que esses herbicidas foram sistematicamente aplicados nos últimos anos. Desenvolveu-se o experimento em casa de vegetação, comparando-se o biótipo resistente ao suscetível, quando submetido aos diversos herbicidas aplicados em pós-emergência. Aplicaram-se quando as plantas encontravam-se no estádio de duas a quatro folhas verdadeiras, nas doses zero, uma, duas, quatro e oito vezes a recomendada. Aos 20 dias após a aplicação, avaliaram-se os parâmetros relativos ao controle e produção de fitomassa epígea visando ao estabelecimento de curvas de doses-resposta, à obtenção dos fatores de resistência com base nos valores da DL50 e GR50, e à verificação da ocorrência de resistência múltipla. O biótipo resistente apresentou diferentes níveis de resistência aos herbicidas chlorimuron-ethyl e imazethapyr, demonstrando resistência cruzada aos inibidores da ALS dos grupos das sulfoniluréias e imidazolinonas. No entanto, foi eficientemente controlado nos tratamentos com fomesafen (250 g.ha-1, lactofen (120 g.ha-1, flumiclorac-pentil (40 g.ha-1, glufosinato de amônio (150 g.ha-1 e glyphosate (360 g.ha-1.Herbicides are the main tool for weed control in soybean crop, but the selection pressure attributed to the repeated application of the same herbicides and the same mechanism of action can

  1. Teores de água no solo e eficácia do herbicida glyphosate no controle de Euphorbia heterophylla Soil water contents and glyphosate efficacy in controlling Euphorbia heterophylla

    Directory of Open Access Journals (Sweden)

    J.F. Zanatta

    2007-12-01

    Full Text Available Um experimento em casa de vegetação foi realizado com os objetivos de avaliar a eficácia do herbicida glyphosate no controle de Euphorbia heterophylla se desenvolvendo em solo com diferentes teores de água e determinar qual o menor teor de água do solo que não prejudica a ação desse herbicida no controle dessa planta daninha. O delineamento utilizado foi o de blocos casualizados em esquema fatorial 6 x 5, sendo seis intervalos entre a última irrigação e a aplicação do herbicida (0, 6, 12, 24, 48 e 72 horas e cinco doses de glyphosate (0, 180, 360, 720 e 1.080 g ha-1. Quando as plantas atingiram estádio de três pares de folhas, foram aplicados 10 mm de chuva simulada, conforme tratamento previsto. Ao término do período de simulação de chuva, aplicou-se o herbicida com pulverizador costal pressurizado com CO2, utilizando-se volume de calda de 120 L ha-1. Aos 7, 20, 34 e 41 dias após aplicação (DAA, foram avaliados o controle (por escala visual e, aos 41 DAA, a massa seca de raízes e da parte aérea. Após análise dos dados, verificou-se que a partir da dose de 720 g ha-1 de glyphosate obteve-se controle satisfatório de E. heterophylla, independentemente do intervalo entre a última irrigação e a aplicação do herbicida. Pulverizações de 360 g ha-1 de glyphosate a intervalos menores que 48 horas entre a última irrigação e sua aplicação e em solo com teor de água maior que 0,09 cm³ cm-3 não prejudicaram a eficácia do herbicida. A aplicação de 180 g ha-1 de glyphosate a intervalos menores que 12 horas entre a última irrigação e sua aplicação e em solo com teor de água superior a 0,14 cm³ cm-3 não afetou a eficácia do herbicida.A greenhouse experiment was carried out to evaluate the efficacy of glyphosate in controlling Euphorbia heterophylla growing under different soil moisture levels and to determine the lowest soil moisture level failing to prevent herbicide effectiveness in controlling this weed

  2. Características morfofisiológicas de biótipos de Euphorbia heterophylla com resistência a diferentes mecanismos de ação herbicida Morphophysiological characteristics of Euphorbia heterophylla biotypes resistant to different herbicide action mechanisms

    Directory of Open Access Journals (Sweden)

    M.M Trezzi

    2009-12-01

    Full Text Available A resistência de plantas daninhas aos herbicidas é um dos maiores entraves da agricultura mundial. No Brasil, Euphorbia heterophylla (EPHHL obtém destaque devido ao fato de apresentar resistência a mais de um mecanismo de ação de herbicidas. O presente trabalho foi conduzido com o objetivo de identificar características morfofisiológicas e a adaptabilidade ecológica entre biótipos de Euphorbia heterophylla com resistência múltipla a inibidores da ALS e Protox e com resistência apenas a inibidores da ALS e suscetível, oriundos da região sudoeste do Paraná. O experimento foi desenvolvido em casa de vegetação. O delineamento utilizado foi o completamente casualizado, com quatro repetições. As características morfofisiológicas avaliadas foram: matéria seca de folhas+cotilédones, de raízes, de caule+pecíolos e total, estatura, número de ramificações por planta, área foliar e número de folhas por planta. Nas determinações efetuadas mais tardiamente, plantas do biótipo S apresentaram menores matérias secas de folhas+cotilédones, caules+pecíolos e total. Plantas do biótipo S também apresentaram menores área foliar, número de ramificações e estatura em avaliações mais tardias, comparativamente aos biótipos R a ALS e R a Protox.Weed resistance to herbicides is one of the major barriers to agriculture worldwide. In Brazil, Euphorbia heterophylla (EPHHL is especially known for presenting resistance to more than one herbicide action mechanism. This work was carried out to identify morphophysiological characteristics and ecological adaptability between Euphorbia heterophylla biotypes with multiple resistance to ALS inhibitors and PROTOX, and with resistance only to ALS inhibitors and susceptible from Southwestern Paraná. The experiment was conducted in a greenhouse and arranged in a completely randomized design, with four replications. The morphophysiological characteristics evaluated were: dry matter of leaves

  3. Integrales Lernen in und von Organisationen

    Directory of Open Access Journals (Sweden)

    Wendelin Kupers

    2006-06-01

    Full Text Available Bezogen auf das integrale Models von Ken Wilber untersucht der Beitrag die Bedeutung des Lernens in und von Organisationen. Nach einer Darstellung der Relevanz und des Grundverständnisses des Lernens im Organisationskontext, werden integrale Dimensionen des Lernens dargestellt. Im Einzelnen werden die verschiedenen Sphären eines inneren-subjektiven und äusseren-„objektiven“ Lernens des Einzelnen als auch ein gemeinschaftliches Lernen und Lernen im System auf der kollektiven Ebene dargestellt sowie deren interrelationaler Zusammenhang diskutiert. Schließlich beschreibt der Beitrag noch integrale Lernprozesse sowie integrale Gestaltungsfelder zur Förderung des Lernens in den verschiedenen Bereichen. Abschließend spricht der Artikel noch Schwierigkeiten und Probleme an sowie nimmt im Fazit ein perspektivischen Ausblick vor.

  4. Laboratory Testing for Von Willebrand Factor Multimers.

    Science.gov (United States)

    Oliver, Susan; Lau, Kun Kan Edwin; Chapman, Kent; Favaloro, Emmanuel J

    2017-01-01

    Von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder and can also arise as an acquired syndrome (AVWS). These disorders develop due to defects and/or deficiency of the plasma protein von Willebrand factor (VWF). Laboratory testing for the VWF-related disorders requires assessment of both VWF level and VWF activity, the latter requiring multiple assays because of the many functions carried out by VWF to help prevent bleeding. As an additional step, an evaluation of VWF structural features by multimer analysis is useful in selective investigations. The current paper therefore describes a protocol for assessment of VWF multimers by gel electrophoresis, thus enabling identification of protein bands that represent differently sized multimers. The sample protocol described in this chapter is the methodology developed by Sebia.

  5. Wir zeigen andere Bilder von Frauen ...

    Directory of Open Access Journals (Sweden)

    Bettina Rulofs

    2010-03-01

    Full Text Available Der vorliegende Beitrag beleuchtet die Bedeutung der Geschlechterordnung im Prozess der sportmedialen Kommunikation. Im Kern geht es um die Frage, inwiefern im Prozess der medialen Vermittlung von Sport traditionelle Geschlechterstereotype aufrechterhalten werden oder Möglichkeiten der Irritation solcher Stereotype bestehen. Dazu werden verschiedene Ebenen des massenmedialen Kommunikationsprozesses in den Blick genommen: die Medienprodukte, die Öffentlichkeitsarbeit und Selbst-Präsentation der Sportler/innen, die Medienrezeption und die Herstellungsprozesse von Medien in den Sportredaktionen. This article illustrates the relevance of gender in processes of sports media communication. The question in focus is in what way traditional gender stereotypes are perpetuated in the process of media communication in sport and how such stereotypes can be irritated. Therefore different levels of mass media communication are considered: the media products, the public relations of athletes and the presentation of themselves as athletes, the media-reception and the production processes in sport departments of media institutions.

  6. Virchow's triad: Kussmaul, Quincke and von Recklinghausen.

    Science.gov (United States)

    Stanifer, John W

    2016-02-01

    For most of the 19th century, Germany was the centre of the medical world. From there the most innovating research came and many of the physicians of that era are known to nearly every medical student and physician of today. Virchow, Kussmaul, Quincke, von Recklinghausen, Müller and Schönlein are familiar names in today's medicine but insofar as they are merely eponyms associated with signs, symptoms, disease and anatomy. The story of their lives, their research and their influence on each other has been little examined. This is an essay about Virchow's relationship with his mentors Müller and Schönlein and how these relationships shaped the development of Kussmaul, Quincke and von Recklinghausen as students of Virchow and their work in medicine and clinical observation after leaving Virchow's laboratory. © The Author(s) 2014.

  7. Evolution equations of von Karman type

    CERN Document Server

    Cherrier, Pascal

    2015-01-01

    In these notes we consider two kinds of nonlinear evolution problems of von Karman type on Euclidean spaces of arbitrary even dimension. Each of these problems consists of a system that results from the coupling of two highly nonlinear partial differential equations, one hyperbolic or parabolic and the other elliptic. These systems take their name from a formal analogy with the von Karman equations in the theory of elasticity in two dimensional space. We establish local (respectively global) results for strong (resp., weak) solutions of these problems and corresponding well-posedness results in the Hadamard sense. Results are found by obtaining regularity estimates on solutions which are limits of a suitable Galerkin approximation scheme. The book is intended as a pedagogical introduction to a number of meaningful application of classical methods in nonlinear Partial Differential Equations of Evolution. The material is self-contained and most proofs are given in full detail. The interested reader will gain a ...

  8. La Medea de Lars von Trier

    Directory of Open Access Journals (Sweden)

    Iratxe Fresneda Delgado

    2013-04-01

    Full Text Available El presente artículo analiza el modo en el que Lars von Trier recrea para el cine el estereotipo de Medea. Mediante el análisis fílmico de la película y apoyándose en los estudios culturales, el texto se interroga acerca de la importancia y el poder potencial del cine a la hora recuperar el antiguo mito y demostrar su vigencia. El análisis amplía horizontes para la compresión de los mecanismos que articulan el entramado de significados de la película, donde Von Trier aporta una nueva visión del arquetipo de Medea uniéndola, a la tradición pictórica del Romanticismo. Una influencia que habita en las posteriores obras del director danés, donde el paisaje, la naturaleza, se erige en elemento catalizador de las pulsiones humanas, en su cómplice y testigo.This paper explores the way that Lars von Trier’s film recreates the stereotype of Medea. Using film analysis and based on cultural studies the article asks about the importance and potential power of cinema to recover the ancient myth and show their effects. The analysis expands horizons for the understanding of the mechanisms that link the network of meanings of the film, where the author offers a new vision of Medea's archetype attaching it to the pictorial tradition tied to the Romanticism. An influence that can be seen in the later works of Lars von Trier, where the landscape, the nature, stands as a catalyst of human drives, as his accomplice and witness.

  9. Von Medien, Übertragungen und Automaten

    Directory of Open Access Journals (Sweden)

    Alessandro Barberi

    2013-12-01

    Full Text Available Im Zuge der Debatten zum Medialen Habitus wurde vielfach betont, dass die >Theorie der Praxispraxeologischen Medientheorie< des Medialen Habitus avant la lettre gesprochen werden kann. Dieser Artikel untersucht – ausgehend von den Debatten zur "Medienkompetenz" – wie Bourdieu Sprache, Sprechen und Diskurs, sowie Akteure, Felder und Habitus als Medien begreift und betont dabei die Nützlichkeit der Bourdieuschen Bildungssoziologie im Rahmen einer sozialwissenschaftlichen Grundlegung der Medienpädagogik.

  10. Untersuchungen von Nanostrukturen magnetischer Kolloide mit Kleinwinkelstreuung

    OpenAIRE

    Kammel, Martin

    2005-01-01

    Mit Hilfe der Neutronenkleinwinkelstreuung mit polarisieren Neutronen wird eine Analyse so genannter Ferrofluide durchgeführt. Ferrofluide sind Dispersionen magnetisierbarer Teilchen, welche durch in den meisten Fällen organische Hüllen gegen irreversibler Aggregation geschützt sind. Anhand von verdünnten Magnetit-Kolloidlösungen wurden als Stabilisierung Dextran, Tenside (Laurinsäure/Marlipal) und elektrostatisch stabilisierte Magnetitteilchen untersucht. Dabei fanden sich in jedem dieser Fl...

  11. Maschinelle Erkennung von Verkehrsteilnehmern mittels heterogener Sensorik

    OpenAIRE

    Walchshäusl, Leonhard

    2009-01-01

    In modernen Fahrzeugen halten verstärkt Fahrerassistenzsysteme zum Insassenschutz und zum Schutz anderer Verkehrsteilnehmer Einzug. Typische, bereits seit längerem verfügbare Systeme, wie Airbag und Antiblockiersystem, erreichen schon heute eine hohe Marktdurchdringung. Künftige aktive Sicherheitssysteme, die von der Kollisionswarnung bis hin zur autonomen Gefahrenbremsung reichen, sind Gegenstand aktueller Forschung. Insbesondere Systeme, die aktiv in das Fahrgeschehen eingreifen, erfordern ...

  12. Mikrobieller Befall von Elektrotauchlack in der Automobilindustrie

    OpenAIRE

    Gühring, Ina Katrin

    2000-01-01

    Nach Umstellung auf umweltverträglichere Lackmaterialien (Reduzierung biozid wirkender Lösemittel, Schwermetalle) traten in Elektrotauchanlagen verschieder Werke der DaimlerChrysler AG vermehrt Beschichtungsstörungen bei Karossen auf. Dabei war ein pH-Anstieg des Lackmaterials, Schichtdickenanstieg, Abblättern des Lacks („Striptease“ Effekt), Oberflächenstörungen (Pusteln, Blasen, Krater), schlechter Umgriff, eine Bildung von Lackschlamm und geringerer Schichtwiderstand zu beobachten. Gleichz...

  13. Die Usability von Rich Internet Applications

    Science.gov (United States)

    Linder, Jörg

    Interaktiven Services, die dem Themenkreis Web 2.0 zugeordnet werden, haftet unter anderem das Attribut an, besonders leicht bedienbar zu sein. Flickr, Youtube und Wikipedia gelten als Erfolgsprojekte dieser neuen Art von interaktiven Websites. Wodurch zeichnet sich nun eine Usability 2.0 (so es sie überhaupt geben sollte) aus? Was ist zu beachten, wenn so genannte Rich Internet Applications gestaltet werden?

  14. Therapie von Vorhofflimmern: Rolle der Katheterablation

    OpenAIRE

    Hindricks G; Kircher S; Gaspar T.; Arya A

    2009-01-01

    Vorhofflimmern ist die häufigste Herzrhythmusstörung in der Gesamtbevölkerung und geht einher mit erhöhter Morbidität und Mortalität. Als prinzipielle Behandlungskonzepte stehen die "Frequenzkontrolle" und die "Rhythmuskontrolle" zur Verfügung. Während sich die medikamentöse Rhythmuskontrolle als insgesamt unzureichend erwiesen hat, stellt die Katheterablation von Vorhofflimmern einen etablierten, potenziell kurativen Therapieansatz mit beachtlichen Erfolgsraten dar. Obwohl hinsichtlich d...

  15. Modellierung von Preiserwartungen durch neuronale Netze

    OpenAIRE

    Heinemann, Maik; Lange, Carsten

    1997-01-01

    Das Papier untersucht, wie Erwartungsbildung mit Hilfe neuronaler Netze modelliert werden kann. Die Grundlage bildet ein Cobweb-Modell, in dem Firmen Preiserwartungen auf Basis eines Feedforward-Netzes bilden.Zunächst wird anhand von Simulationen gezeigt, daß Firmen durch neuronale Erwartungsbildung approximativ rationale Erwartungen bilden können. Im Gegensatz zur Hypothese rationaler Erwartungen ist dafür die Kenntnis des relevanten Modells nicht mehr erforderlich, lediglich Beobachtungen d...

  16. Expression von Blutgruppenantigenen durch humane mesenchymale Stammzellen

    OpenAIRE

    Schüle, Michael Christian

    2013-01-01

    Die vorliegende experimentelle Arbeit befasst sich mit der Untersuchung der Expression von Blutgruppenantigenen durch humane mesenchymale Stammzellen (MSC) aus dem Knochenmark. Der Fokus lag hierbei auf den klinisch bedeutsamen Antigenen A, B, H, Rhesus-D, -C, -c, -E, -e, RhAG, K, k, Jka, Jkb und DARC. Die Expression wurde systematisch auf Genom-, Transkriptom- und Proteinebene evaluiert. Alle untersuchten MSC Populationen exprimierten FUT1, RHCE, KEL und Kidd (HUT11) mRNA. mRNA der AB0-Gl...

  17. Weitere Vorkommen von Impatiens capensis in Hessen

    OpenAIRE

    Nawrath, Stefan

    1996-01-01

    Neue hessische Fundorte von Impatiens capensis aus dem Taunus und dessen Vorland sowie aus der Rheinebene werden berichtet. Die insbesondere im Schwarzbach-System zahlreichen Fundorte werden beschrieben und in einer Verbreitungskarte dargestellt. New Hessian stations of Impatiens capensis in the Taunus mountains as well as their foothills and in the Rhine valley are reported on. The stations which are particularly numerous in the Schwarzbach system, are described and demonstrated on a dist...

  18. [Orthopaedic manifestations of Von Recklinghausen's neurofibromatosis].

    Science.gov (United States)

    Trigui, Moez; Ayadi, Kamel; Sakka, Mourad; Zribi, Wassim; Frikha, Faten; Gdoura, Fakher; Sallemi, Sami; Zribi, Mohamed; Keskes, Hassib

    2011-03-01

    Von Recklinghausen's neurofibromatosis is a dominant autosomic genetic disease characterized by different clinical manifestations. The goal of this work was to study its orthopaedic manifestations and to show the characteristics of their management. A retrospective study was carried out on 15 patients having a Von Recklinghausen's neurofibromatosis. For each patient, different orthopaedic manifestations and their evolution after treatment were analyzed. These manifestations were classified in spinal deformities, pseudarthrosis of long bones and tumours of the peripheral nerves. The spinal deformities were observed in 9 cases. A dystrophic scoliosis was observed in 6 patients with an average angle of 50° and was associated to a kyphosis in 5 patients. The treatment was surgical by posterior arthrodesis in 2 cases and circumferential arthrodesis in 2 cases. The congenital curves and pseudarthroses of leg were observed in 5 cases, localized at the lower third of the leg in all cases. An Ilizarov external fixator with segmental osseous transport was carried out in 2 patients. The duration of the external fixator was 23 months ½ with 5 interventions in each case. Four plexiform neurofibromas and 3 nodular neurofibromas were observed. A transformation into neurofibrosarcoma was found in 2 patients. In one case, a resection without functional sacrifice was carried out and in the other case the patient was dead before the resection. The orthopaedic manifestations of Von Recklinghausen's neurofibromatosis are frequent, varied and have a difficult management. The functional and sometimes vital prognoses are challenging. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  19. Treatment of patients with von Willebrand disease

    Directory of Open Access Journals (Sweden)

    Tuohy E

    2011-04-01

    Full Text Available Emma Tuohy1, Emma Litt1, Raza Alikhan1,21Department of Haematology, University Hospital of Wales, Cardiff, UK; 2Haemophilia and Thrombosis Centre, University Hospital of Wales, Cardiff, UKAbstract: Von Willebrand disease (vWD is the most common hereditary bleeding disorder. The aim of therapy is to correct the dual hemostatic defect, due to defective platelet adhesion-aggregation and abnormal coagulation due to Factor VIII (FVIII deficiency. The choice of treatment depends on a number of factors, including the severity of the bleed, the procedure planned, the subtype and severity of the disease and the age and morbidity of the patient. Desmopressin (DDAVP is the treatment of choice for type 1 vWD as it increases endogenous release of FVIII and von Willebrand factor (vWF and is also used in some subtypes of type 2 vWD. In those patients in whom DDAVP is ineffective or contraindicated, levels can be restored by infusing vWF:FVIII concentrates. The role of antifibrinolytic treatment is an important adjunct to replacement therapy during minor or major surgery involving mucosal surfaces. The dosing and timing of vWF:FVIII concentrates is important depending on the nature of the surgical procedure. The role of secondary prophylaxis needs to be further defined.Keywords: von Willebrand disease, treatment, DDAVP 

  20. Green synthesis of the Cu/ZnO nanoparticles mediated by Euphorbia prolifera leaf extract and investigation of their catalytic activity.

    Science.gov (United States)

    Momeni, Seyedeh Samaneh; Nasrollahzadeh, Mahmoud; Rustaiyan, Abdolhossein

    2016-06-15

    A green synthesis process was developed for the preparation of the Cu/ZnO nanoparticles (NPs) using Euphorbia prolifera leaf extract as a mild, renewable and non-toxic reducing agent and efficient stabilizer without using dangerous, hazardous and toxic materials. The approach of biosynthesis appears to be cost efficient eco-friendly and easy alternative to conventional methods of the Cu/ZnO NPs synthesis. The Cu/ZnO NPs were characterized by FESEM, EDS, elemental mapping, TEM and XRD. TEM micrograph has shown the formation of Cu NPs with the size in the range of 5-17 nm. In addition, the synthesized Cu/ZnO NPs presented excellent catalytic activity for the degradation of Methylene blue (MB) and Congo red (CR) in the presence of NaBH4 in water at room temperature. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Green synthesis of Ag/Fe(3)O(4) nanocomposite using Euphorbia peplus Linn leaf extract and evaluation of its catalytic activity.

    Science.gov (United States)

    Sajjadi, Mohaddeseh; Nasrollahzadeh, Mahmoud; Mohammad Sajadi, S

    2017-07-01

    In this work, the Ag/Fe3O4 nanocomposite was prepared by Euphorbia peplus Linn (L.) leaf extract as a suitable reducing source and stabilizing agent. The green synthesized nanocomposite was characterized using X-ray diffraction analysis (XRD), field emission scanning electron microscope (FESEM), transmission electron microscopy (TEM) images, energy-dispersive X-ray spectroscopy (EDS) and FT-IR spectroscopy. TEM analysis of Ag/Fe3O4 nanocomposite showed the spherical shape nanoparticles (NPs) with an average size of 5-10nm. The Ag/Fe3O4 nanocomposite then was used as a magnetically recoverable catalyst for the [2+3] cycloaddition of arylcyanamides and sodium azide in high yields and short reaction times without formation of hydrazoic acid (HN3). Also it can be easily recovered via applying of external magnetic field and reused several times without significant loss of activity. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Gestalt und Funktion von Animal Design : Versuch einer semiotischen Analyse

    OpenAIRE

    Schlüter, Wolfgang

    2009-01-01

    Dissertation zur Gestalt und Funktion von Animal Design (tieranaloges Design). Untersucht wird eine Auswahl an Produkten, die in ihrem Äußeren an Tiere erinnern. Hierbei stehen Aspekte wie die Emotionalisierung von Produkten, demonstrativer Konsum und die soziale Funktion im Fokus der Analyse. Anhand von Abbildungen und Zeichnungen wird u.a. dargestellt, welche Bedeutung die Tiergestalt für das jeweilige Produktdesign hat. Die Objekte werden jeweils unter phänomenologischen, hermeneutischen u...

  3. Bioethik in der Ukraine: Von Medizinischer zur Integrativen Bioethik

    OpenAIRE

    Gubenko, Anna

    2014-01-01

    Im Artikel wird die Chronologie der Entstehung und Entwicklung der Bioethik in der Ukraine analysiert. Dabei werden drei Hauptetappen der Herausbildung von Bioethik als a) einer gesellschaftlichen Organisation, b) einer Lerndisziplin und c) einer integrativen Wissenschaft unterschieden. Der Autor hat den Vektor von medizinischer zur integrativen Bioethik durch Ausbildung und soziale sowie pädagogische Praktiken bezeichnet. In diesem Sinne wird der Begriff von “pädagogischer Bioethik“ einge...

  4. Portrait of Dr. Von Braun with Walt Disney, 1954.

    Science.gov (United States)

    1954-01-01

    Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

  5. Risiko und Akzeptanz von Industrieansiedlungen: Eine empirische Studie

    OpenAIRE

    Burgemeister, Jörg; Weber, Martin

    1992-01-01

    In der Bundesrepublik Deutschland stoßen Industrieansiedlungen oft auf den Widerstand der Bevölkerung. Bei der Akzeptanz einer Ansiedlung sind von den Bürgern subjektiv wahrgenommene Risiken und Nutzen der Ansiedlung von erheblicher Bedeutung. In einer Fragebogenstudie haben wir untersucht, wie Personen die Nutzen und Risiken von Industrieansiedlungen einschätzen, inwieweit sie Absiedlungen akzeptieren, welche Bestimmungsfaktoren ihren Risiko- und Akzeptanzurteilen zugrundeliegen, und wie sic...

  6. Erfolgsfaktoren von Internet-Auktionen: Eine empirische Analyse in PLS

    OpenAIRE

    Fritz, Wolfgang; Möllenberg, Antje; Dees, Heiko

    2004-01-01

    Internet-Auktionen haben sich zu einem der erfolgreichsten Geschäftsmodelle im E-Commerce entwickelt. Die stetig steigende Anzahl von Auktionen beim Marktführer eBay zeugen von einer zunehmenden Beliebtheit solcher Auktionen. Doch welche Determinanten beeinflussen den Erfolg einer Internet-Auktion? Im vorliegenden Beitrag wird dieses Thema aus dem Blickwinkel des Verkäufers am Beispiel von Ticket-Auktionen empirisch untersucht. Im Mittelpunkt steht dabei eine Kausalanalyse, die den Einfluss v...

  7. Saage tuttavaks : Elisabeth ja Karl von Hoerschelmann / Mai Levin

    Index Scriptorium Estoniae

    Levin, Mai, 1942-

    2004-01-01

    Kuraator M. Levin kuni 10. X 2004 Adamson-Ericu muuseumis avatud näitusest "Tuntud ja tundmatud Elisabeth von Rosendorff-Hoerschelmann ja Karl von Hoerschelmann". Enamik töid on kunstnike laste Konstantin Hoerschelmanni ja Anna Röder-Hoerschelmanni omand. Elisabeth Rosendorff (1898-1984) sündis Virumaal Maidlas eesti perekonnas, Karl von Hoerschelmann (1899-1951) Sevastoopolis saksa perekonnas

  8. Abbaukinetiken - und mechanismen von Lignin und Vanillin unter hydrothermalen Bedingungen

    OpenAIRE

    Curtze, Jan Henning

    2017-01-01

    Eine Methode zur energetischen Aufkonzentrierung von feuchten Abfallbiomassen ist die Hydrothermale Carbonisierung (HTC). Um technische HTC-Reaktoren rational auslegen zu können, sollte die Formalkinetik der vier Hauptkomponenten von Biomasse - Kohlenhydrate, Lignin, Fette/Öle und Proteine – bekannt sein. Des Weiteren spielt die Änderungskinetik des Feststoffes während der HTC eine wichtige Rolle. Der Fokus dieser Arbeit liegt auf der Untersuchung der HTC von Lignin, was ein hochkomplexes, ch...

  9. Studien zur Kinetik der Fehlfaltung un Aggregation von Proteinen

    OpenAIRE

    Modler, Andreas Johannes

    2003-01-01

    Diese Arbeit befasst sich mit der Kinetik der Fehlfaltung und Aggregation von Proteinen. Anhand dreier Beispiele, der Phosphoglyceratkinase (PGK) aus Hefe, einer Variante von Barstar und des Prion-Proteins des Syrischen Hamsters (SHaPrP(90-232)) wurde insbesondere die Kinetik der Bildung von Amyloidfibrillen und deren kinetischer Vorläuferstrukturen mittels dynamischer und statischer Lichtstreuung, Circulardichroismus, Infrarotspektroskopie, Elektronenmikroskopie und teilweise analytischer Ch...

  10. A Ca2+/calmodulin-binding peroxidase from Euphorbia latex: novel aspects of calcium-hydrogen peroxide cross-talk in the regulation of plant defenses.

    Science.gov (United States)

    Mura, Anna; Medda, Rosaria; Longu, Silvia; Floris, Giovanni; Rinaldi, Andrea C; Padiglia, Alessandra

    2005-11-01

    Calmodulin (CaM) is a ubiquitous Ca(2+) sensor found in all eukaryotes, where it participates in the regulation of diverse calcium-dependent physiological processes. In response to fluctuations of the intracellular concentration of Ca(2+), CaM binds to a set of unrelated target proteins and modulates their activity. In plants, a growing number of CaM-binding proteins have been identified that apparently do not have a counterpart in animals. Some of these plant-specific Ca(2+)/CaM-activated proteins are known to tune the interaction between calcium and H(2)O(2) in orchestrating plant defenses against biotic and abiotic stresses. We previously characterized a calcium-dependent peroxidase isolated from the latex of the Mediterranean shrub Euphorbia characias (ELP) [Medda et al. (2003) Biochemistry 42, 8909-8918]. Here we report the cDNA nucleotide sequence of Euphorbia latex peroxidase, showing that the derived protein has two distinct amino acid sequences recognized as CaM-binding sites. The cDNA encoding for an E. characias CaM was also found and sequenced, and its protein product was detected in the latex. Results obtained from different CaM-binding assays and the determination of steady-state parameters showed unequivocally that ELP is a CaM-binding protein activated by the Ca(2+)/CaM system. To the best of our knowledge, this is the first example of a peroxidase regulated by this classic signal transduction mechanism. These findings suggest that peroxidase might be another node in the Ca(2+)/H(2)O(2)-mediated plant defense system, having both positive and negative effects in regulating H(2)O(2) homeostasis.

  11. Total steroid and terpenoid enriched fraction from Euphorbia neriifolia Linn offers protection against nociceptive-pain, inflammation, and in vitro arthritis model: An insight of mechanistic study.

    Science.gov (United States)

    Palit, Partha; Mandal, Subhash C; Bhunia, Biswanath

    2016-12-01

    The plant Euphorbia neriifolia Linn has been successfully used for the management of acute inflammatory, arthritic, nociceptive pain and relieves the asthmatic symptom as a tribal folk medicine in India. The present study was conducted to evaluate the anti-inflammatory, analgesic, anti-arthritic activity from total steroid and terpenoid rich fractions derived from hydro-alcoholic extract of Euphorbia neriifolia stem (STF-HAENS). STF-HAENS fraction demonstrated 68.58±2.5% and 75.25±5.1% protection against acetic acid-induced pain and central neuropathic pain at 80mg/kg. It also showed 98.47% protection against acute inflammation at 100mg/kg with 1.7 fold higher protective activity than the standard drug. The fraction exhibited this efficacy via inhibition of proinflammatory cytokines TNF-α, IFN-γ, IL-12 and IL-6 by 74%, 81.26%, 92.10% and 93.4% respectively at 100μg/ml. It also showed dual inhibition of cyclooxygenase (COX) and lipooxygenase (LOX) activity in a dose-dependent manner that elicited the desired pharmacological action. The fraction downregulated nitric-oxide production from lipopolysaccharide (LPS) stimulated PBMC derived macrophages. The spectrophotometric analysis reveals the STF-HAENS induced ameliorative effect against heat-induced denaturation of BSA protein and exhibited significant antiproteinase activity. Our findings suggest that STF-HAENS could be used as an effective safe therapeutic agent for treatment of nociceptive pain, acute inflammation and arthritis. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Dr. von Braun and Army Ballistics Missile Agency (ABMA) Group

    Science.gov (United States)

    1959-01-01

    This photograph of Dr. von Braun, shown here to the left of General Bruce Medaris, was taken in the fall of 1959, immediately prior to Medaris' retirement from the Army. At the time, von Braun and his associates worked for the Army Ballistics Missile Agency in Huntsville, Alabama. Those in the photograph have been identified as Ernst Stuhlinger, Frederick von Saurma, Fritz Mueller, Hermarn Weidner, E.W. Neubert (partially hidden), W.A. Mrazek, Karl Heimburg, Arthur Rudolph, Otto Hoberg, von Braun, Oswald Lange, Medaris, Helmut Hoelzer, Hans Maus, E.D. Geissler, Hans Heuter, and George Constan.

  13. Einfluss von rekombinantem Adiponektin auf die monozytäre Expression von Annexin A6

    OpenAIRE

    Stögbauer, Fabian

    2009-01-01

    In der vorliegenden Arbeit wurden zunächst die CD14 Micro Beads titriert und so die Menge an CD14 Micro Beads bestimmt, die nötig ist, um eine große Anzahl Monozyten mit einem hohen Reinheitsgrad, verbunden mit geringen Kosten, aus Vollblut isolieren zu können. In den folgenden in vitro Untersuchungen wurden dann periphere Monozyten von humanen Spendern isoliert, um die dosis- und zeitabhängige Veränderung der Annexin A6-Proteinexpression unter dem Einfluss von Adiponektin feststellen zu k...

  14. Avaliação da atividade moluscicida do látex de três espécies de Euphorbia (Euphorbiaceae sobre Leptinaria unilamellata d'Orbigny, 1835 (Gastropoda - Subulinidae Assessment of moluscicidal activity of the latex of three Euphorbia (Euphorbiaceae species on Leptinaria unilamellata d'Obigny 1835 (Gastropoda - Subulinidae

    Directory of Open Access Journals (Sweden)

    I.S Afonso-Neto

    2010-03-01

    Full Text Available Gastrópodes pulmonados terrestres podem atuar como hospedeiros intermediários de helmintos. Os primeiros registros do controle químico desses invertebrados datam do início do século XX e as substâncias utilizadas eram toxinas inespecíficas já empregadas no controle de outras pragas. Moluscicidas sintéticos apresentam limitações técnicas que estimularam a busca de substitutos naturais. Dentre as várias espécies vegetais com atividade moluscicida, Euphorbia cotinifolia L., Euphorbia milii des Moul. var. splendens (Bojer ex Hook Ursch & Leandri e Euphorbia tirucalli L. despertam atenção pelos excelentes resultados obtidos sobre moluscos aquáticos. Contudo, estudos sobre a atividade de plantas moluscicidas em moluscos terrestres são pouco comuns, apesar de sua grande importância parasitológica e agrícola. As semelhanças anatomo-fisiológicas entre espécies de moluscos aquáticos e terrestres sugerem que estratégias de controle químico possam ter eficiência semelhante para os dois grupos de invertebrados. Com base nessa hipótese, o presente trabalho teve como objetivo avaliar a atividade moluscicida do látex de três espécies do gênero Euphorbia sobre Leptinaria unilamellata d'Orbigny, 1835, gastrópode terrestre descrito como hospedeiro intermediário de helmintos trematódeos digenéticos que parasitam animais domésticos. Destas E. milii var. splendens apresentou efeito moluscicida elevado sobre L. unilamellata, 100% até uma diluição de 1:800, já nos primeiros minutos após a aplicação. Embora citadas na literatura como tóxicas para moluscos aquáticos, E. cotinifolia e E. tirucalli não exibiram atividade moluscicida sobre L. unilamellata. Os resultados do presente estudo indicam que o látex de E. milii var. splendens pode se constituir em uma estratégia viável de controle químico de moluscos terrestres.Pulmonate terrestrial gastropods can be intermediate hosts for helminthes. The first records of

  15. Einfluss von Eugenol und Silikonöl auf die Dentinhaftung von adhäsiven Befestigungsmaterialien

    OpenAIRE

    Bigdali, Puria

    2015-01-01

    Zielsetzung Eugenolhaltige Zemente und Silikone stehen in Verdacht den Verbund von Kompositzementen zu beeinflussen. Ziel dieser Arbeit war es den Einfluss eugenolhaltiger und eugenolfreier Zemente und von Additions- und Kondensationssilikonen auf konventionell adhäsive und selbstadhäsive Kompositzemente zu untersuchen. Material und Methode Aus 200 extrahierten Rinderzähnen wurden 200 Dentinscheiben mit einer Dicke von 1 mm hergestellt, in welche eine definierte Kavität mit einem ...

  16. Automatisierte Generierung von Postleitzahlgebieten aus OpenStreetMap-Daten unter Verwendung von Open Source GIS Software

    OpenAIRE

    Hauck, Christian

    2011-01-01

    Das Projekt OpenStreetMap als freie Wiki-Weltkarte gewinnt als Quelle von Geodaten für unter-schiedlichste Bedürfnisse innerhalb der Geowissenschaften, des Geomarketings und auch im Alltag immer mehr an Bedeutung. Die kostenlosen, von Freiwilligen einer Community gesammelten geo-graphischen Daten, sogenannte nutzergenerierte Daten, dienen heute vielen Anwendern als Daten-grundlage und stehen in der Konkurrenz zu proprietären Geodaten von kommerziellen Anbietern. Neben Straßendaten sind zahlre...

  17. Ööklubi Club von Überlingen = Club von Überlingen

    Index Scriptorium Estoniae

    2008-01-01

    Ööklubi Club von Überlingen (Madara 22A, Tallinn) sisekujundusest. Sisearhitekt: Taavi Aunre (Boom.ee OÜ). Taavi Aunrest, tema tähtsamad tööd. I-II korruse plaan, 11 värv. vaadet, foto T. Aunrest

  18. Von den Liven von Oesel / August Ludwig Schlözer

    Index Scriptorium Estoniae

    Schlözer, August Ludwig

    2008-01-01

    Avaldatud Eberhard Winkleri initsiatiivil A. L. Schlözeri teose põhjal: Gesammelte Nachrichten von den Ueberresten der Liven, in Livland und Kurland. (1770), mis moodustab osa teosest: Schlözer, August Ludwig. M. Johann Joseph Haigold's Beylagen zum Neuveränderten Russland. Zweiter Theil. Riga und Leipzig, 1770

  19. Aino Lepik von Wiren / Aino Lepik von Wiren ; interv. Kadi Alatalu

    Index Scriptorium Estoniae

    Lepik von Wirén, Aino, 1961-

    2007-01-01

    Heinrich Marga eksiilvalitsuse (20.06.1990-7.10.1992) kohtuminister Aino Lepik von Wiren pagulaslapse elust Rootsis, haridusest ja elukutse valikust, tööst eksiilvalitsuses, tööleasumisest Eestisse 1992. aastal, seadusandlikust tegevusest ning aluse panekust välismaalaste- ja kodakondsuspoliitikale, naiste võimalustest poliitilisse tippu tõusmiseks, kodu- ja väliseestlaste vastandamisest

  20. Rezension: Träume von Räumen von Georges Perec

    Directory of Open Access Journals (Sweden)

    Thomas Ballhausen

    2015-12-01

    Full Text Available Mit "Träume von Räumen" liegt ein zentraler Text aus dem umfangreichen Œuvre Geroges Perecs vor, der zuletzt 1990 als Übersetzung greifbar war. Der ursprünglich 1974 erschienene Band ist in mehrfacher Hinsicht wesentlich für das Verständnis Perecs und seiner literarisch-philosophische Wunderwelt ...

  1. Wege des Exports von Glutathion aus Astrocyten

    OpenAIRE

    Minich, Tobias Florian

    2008-01-01

    Vorliegender Arbeit lag die Aufgabe zugrunde herauszufinden, welche(s) Transportsystem(e) außer dem Multidrug-Transporter 1 (multidrug resistance protein 1, MRP1) zum Austritt des Tripeptides Glutathion aus Primärkulturen von Astrogliazellen in das extrazelluläre Milieu beitragen. Als Grundlage für die Untersuchungen wurde zunächst an zwei Wildtyp Mausstämmen (NMRI und FVB/N) sichergestellt, dass astrogliareiche Primärkulturen aus Mäusen sowohl reduziertes als auch oxidiertes Glutathion expor...

  2. Die Behandlung von Intersexuellen in der Diskussion

    Directory of Open Access Journals (Sweden)

    Heinz-Jürgen Voß

    2008-11-01

    Full Text Available Wissenschaftler/-innen aus unterschiedlichen Fachdisziplinen und mit unterschiedlichen Ansichten zum Umgang mit intersexuellen Menschen kommen zu Wort – in diesem Sinne ist der Sammelband sehr heterogen. Es werden Erfahrungen mit Geschlechtsanpassung dargestellt, Begrifflichkeiten analysiert und Probleme bei der Therapie und in der Forschung erörtert. Vorangestellt, aber erfreulicherweise nicht abgetrennt, äußern sich Betroffene. Bereits wegen der sich im Abschluss des Bandes befindlichen Handlungsempfehlungen zur Behandlung von Säuglingen und Kindern mit ‚abweichenden‘ bzw. ‚uneindeutigen‘ Geschlechtsmerkmalen, die sich insbesondere an Eltern, Mediziner/-innen und Sozialpädagog/-innen wenden, ist das Buch unbedingt empfehlenswert.

  3. Electronic Resource Management System. Vernetzung von Lizenzinformationen

    OpenAIRE

    Michaela Selbach; Daniel Armin Rupp

    2014-01-01

    In den letzten zehn Jahren spielen elektronische Ressourcen im Bereich der Erwerbung eine zunehmend wichtige Rolle: Eindeutig lässt sich hier ein Wandel in den Bibliotheken (fort) vom reinen Printbestand zu immer größeren E-Only-Beständen feststellen. Die stetig wachsende Menge an E-Ressourcen und deren Heterogenität stellt Bibliotheken vor die Herausforderung, die E-Ressourcen effizient zu verwalten. Nicht nur Bibliotheken, sondern auch verhandlungsführende Institutionen von Konsortial- und ...

  4. Authentifizierung von Bio-Milch im Labor

    OpenAIRE

    Molkentin, Joachim

    2008-01-01

    In Deutschland ist die Nachfrage nach Bio-Lebensmitteln in den letzten Jahren stetig gestiegen. So erhöhte sich der Absatz von Bio-Trinkmilch in 2007 im Vergleich zum Vorjahr erneut kräftig um 34 Prozent (ZMP, Bonn) und der Bio-Anteil beträgt inzwischen bei Frischmilch knapp elf Prozent. Aufgrund sporadisch resultierender Lieferengpässe bei Bio-Milch sowie der vorhandenen Handelspreisdifferenz besteht zunehmend ein potenzielles Risiko der Falschdeklaration konventionell erzeugter Milch als Bi...

  5. Der Denkmalwert von Illegalität

    OpenAIRE

    Beyer, Dennis

    2012-01-01

    Kunst oder Schmiererei - Graffiti spalten die Gesellschaft. Für die einen sind sie illegale Schmierereien und Ausdruck von Vandalismus, für die anderen gelten sie als Kunst am Bau einer verkannten Avantgarde. Das Spektrum an Motivationen und Produkten innerhalb der Sprayer-Gemeinschaft ist tatsächlich derart vielfältig, dass eine sachliche Debatte ohne Polarisation kaum möglich scheint. Dennoch stellt sich die Frage, welche Bedeutung diese flüchtigen und illegalen Zeugnisse einer Minderheit i...

  6. Comparison of automated von Willebrand factor activity assays

    DEFF Research Database (Denmark)

    Timm, Annette; Hillarp, Andreas; Philips, Malou

    2015-01-01

    INTRODUCTION: Von Willebrand Disease (VWD) is the most common inherited bleeding disorder. Measurement of von Willebrand factor (VWF) activity in plasma is often based on platelet agglutination stimulated by the ristocetin cofactor activity. Novel assays, based on latex beads with recombinant...

  7. Illustrierte Bestimmungshilfe zur Unterscheidung von Candelaria concolor und Candelaria pacifica

    OpenAIRE

    Stapper, Norbert J.

    2012-01-01

    Unterscheidungsmerkmale von Candelaria concolor und C. pacifica werden anhand von Makro- und Mikrofotos dargestellt. Im Gelände kann C. pacifica anhand der fehlenden Unterrinde erkannt werden. Characteristic features separating Candelaria concolor from C. pacifica are presented on macro and micro photographs. The lack of a lower cortex can be used to identify C. pacifica in the field.

  8. On two matrix derivatives by Kollo and von Rosen

    OpenAIRE

    Neudecker, Heinz

    2003-01-01

    The article establishes relationships between the matrix derivatives of Fwith respect to Xas introduced by von Rosen (1988), Kollo and von Rosen (2000) and the Magnus-Neudecker (1999) matrix derivative. The usual transformations apply and the Moore-Penrose inverse of the duplication matrix is used. Both Xand F have the same dimension. Peer Reviewed

  9. A New Generalization of von Neumann Relative Entropy

    Science.gov (United States)

    Li, Jing; Cao, Huaixin

    2017-11-01

    In quantum information, von Neumann relative entropy has a great applications and operational interpretations in diverse fields, and von Neumann entropy is an important tool for describing the uncertainty of a quantum state. In this paper, we generalize the classical von Neumann relative entropy S( ρ|| σ) and von Neumann entropy S( ρ) to f-von Neumann relative entropy \\widetilde {S}f(ρ ||σ ) and f-von Neumann entropy \\widetilde {S}f(ρ ) induced by a logarithm-like function f, respectively, and explore their properties. We prove that \\widetilde {S}f(ρ ||σ ) is nonnegative and then prove that \\widetilde {S}f(ρ ) has nonnegativity, boundedness, concavity, subadditivity and so on. Later, we show the stability and continuity of the \\widetilde {S}f(ρ ) with respect to the trace distance. In the case that f( x) = -log x, the resulted entropies reduce the classical von Neumann relative entropy and von Neumann entropy, respectively. This means that our results extend the usual results to a more general setting and then have some potential applications in quantum information.

  10. An accurate von Neumann's law for three-dimensional foams

    NARCIS (Netherlands)

    Hilgenfeldt, Sascha; Kraynik, Andrew M.; Koehler, Stephan A.; Stone, Howard A.

    2001-01-01

    The diffusive coarsening of 2D soap froths is governed by von Neumann's law. A statistical version of this law for dry 3D foams has long been conjectured. A new derivation, based on a theorem by Minkowski, yields an explicit analytical von Neumann's law in 3D which is in very good agreement with

  11. Minimum Moduli in Von Neumann Algebras | Gopalraj | Quaestiones ...

    African Journals Online (AJOL)

    Minimum Moduli in Von Neumann Algebras. Perumal Gopalraj, Anton Ströh. Abstract. In this paper we answer a question raised in [12] in the affirmative, namely that the essential minimum modulus of an element in a von. Neumann algebra, relative to any norm closed two-sided ideal, is equal to the minimum modulus of the ...

  12. Spin–momenta entanglement in moving frames: Properties of von ...

    Indian Academy of Sciences (India)

    well as locality, of information [9–11]. Expressed differently, the von Neumann entropy measures the stored qubits of information per states of the combined system while the reduced one quantifies the qubits per states that may be stored in one of the subsystems. [1]. It is then obvious that a deeper understanding of von ...

  13. Victor or Villain? Wernher von Braun and the Space Race

    Science.gov (United States)

    O'Brien, Jason L.; Sears, Christine E.

    2011-01-01

    Set during the Cold War and space race, this historical role-play focuses on Wernher von Braun's involvement in and culpability for the use of slave laborers to produce V-2 rockets for Nazi Germany. Students will grapple with two central questions. Should von Braun have been allowed to emigrate to the United States given his affiliation with the…

  14. Von Krahli teatris etenduvad Tõnu Kõrvitsa kammerooperid / Esme Kassak

    Index Scriptorium Estoniae

    Kassak, Esme

    2006-01-01

    20. apr. esietenduvad Von Krahli Teatris Peeter Jalaka lavastuses Tõnu Kõrvitsa uued kammerooperid "Tuleaed" ja "Mu luiged, mu mõtted", mille aluseks on luuletaja Marie Heibergi saatus. Libretode autor on Maarja Kangro. Kammerooperid tulevad lavale Von Krahli Teatri ja Nargen Opera koostöös. Esitavad Kädy Plaas, Helen Lokuta, Nargen Opera koor ja Tallinna Kammerorkester, dirigent Tõnu Kaljuste

  15. von Willebrand disease and aging : an evolving phenotype

    NARCIS (Netherlands)

    Sanders, Y. V.; Giezenaar, M. A.; Laros-van Gorkom, B. A. P.; Meijer, K.; van der Bom, J. G.; Cnossen, M. H.; Nijziel, M. R.; Ypma, P. F.; Fijnvandraat, K.; Eikenboom, J.; Mauser-Bunschoten, E. P.; Leebeek, F. W. G.

    Background: Because the number of elderly von Willebrand disease (VWD) patients is increasing, the pathophysiology of aging in VWD has become increasingly relevant. Objectives: To assess age-related changes in von Willebrand factor (VWF) and factor VIII (FVIII) levels and to compare age-related

  16. [Heinz von zur Mühlen. Das Bürgertum Fordert Blut. Ein Bolschewistiches Flugblatt von 1918] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2007-01-01

    Arvustus: Heinz von zur Mühlen. Das Bürgertum Fordert Blut. Ein Bolschewistiches Flugblatt von 1918. In : Ostseeprovinzen, baltische Staaten und das Nationale. Münster : LIT, 2005, lk. 403-414. 1918. aastast pärit lendlehest, mille käekirja järgi otsustades on kirjutanud Viktor Kingissepp

  17. Kontextualisierung von Queer Theory Contextualizing Queer Theory

    Directory of Open Access Journals (Sweden)

    Anna Voigt

    2008-03-01

    Full Text Available Christine M. Klapeer legt in diesem Einführungsband dar, aus welchen politischen und theoretischen Kontexten heraus sich ‚queer‘ zu einem Begriff mit besonderem politischem und theoretischem Gehalt entwickelt hat. Wesentlich zielt sie dabei auf eine kritische Kontextualisierung von „queer theory”. Die Autorin geht zunächst auf das Gay Liberation Movement ein, grenzt die Queer Theory vom Poststrukturalismus, von feministischen Theorien und den Lesbian and Gay Studies ab, beleuchtet Eckpunkte queeren Denkens und zeichnet schließlich die Entwicklungen in Österreich sowohl politisch-rechtlich als auch bewegungsgeschichtlich und in der Wissenschaftslandschaft nach.Christine M. Klapeer’s introductory volume demonstrates the manner in which ‘queer’ grew out of various political and theoretical contexts to become a term with special political and theoretical content. She focuses primarily on a critical contextualization of “queer theory.” The author begins by approaching the Gay Liberation Movement and then distinguishes Queer Theory from poststructuralism, from feminist theories, and from Lesbian and Gay Studies. She continues on to illuminate the key aspects of queer thought and concludes by sketching the development in Austria in terms of politics and the law, the history of movements, and within the landscape of knowledge.

  18. Guy von Dardel 1919-2009

    CERN Multimedia

    2009-01-01

    Guy von Dardel, a well-known figure at CERN and in the international particle physics community, passed away on 28 August. Guy von Dardel came to CERN when it was founded in 1954 and was a full-time staff member until 1964, performing several experiments and working on technical developments. These included the first measurement of the neutral pion’s life-time. Called to Lund University in 1964, he became professor there in 1965 and director of the 1.2 GeV electron accelerator. In the late 1960s, he performed an experiment at CERN’s PS that measured the decays of the Λ. Then, in the early 1970s, he involved the Lund group in a series of experiments at the Intersecting Storage Rings (ISR), where he measured the production of various types of particles. In particular, he participated in a series of experiments that observed the production of a high abundance of particles with large transverse momenta. This required an explanation...

  19. Suitability of tracers; Eignung von Tracern

    Energy Technology Data Exchange (ETDEWEB)

    Klotz, D. [GSF - Forschungszentrum fuer Umwelt und Gesundheit GmbH, Neuherberg (Germany). Inst. fuer Hydrologie

    1999-02-01

    Hydrological tracer techniques are a means of making statements on the direction and speed of underground water. One of the simpler tasks is to find out whether there is hydrological communication between two given points. This requires a determination of the direction of flow, which places less exacting demands on the properties of the tracer than does the task of determining the flow velocity of underground water. Tracer methods can serve to infer from flow velocity the distance (flow) velocity, which is defined as the ratio between the distance between two points located in flow direction and the actual time it takes water to flow from one to the other. [Deutsch] Mit Hilfe der hydrologischen Markierungstechniken koennen Aussagen ueber die Richtung und die Geschwindigkeit von Bewegungen des unterirdischen Wassers gemacht werden. Der einfachere Fall liegt vor, wenn festgestellt werden soll, ob zwischen zwei Punkten eine hydrologische Verbindung besteht. Bei dieser Fliessrichtungsbestimmung sind die Forderungen an die Eigenschaften der einzusetzenden Tracer geringer als bei der Bestimmung der Geschwindigkeit des unterirdischen Wassers. Von den Geschwindigkeiten des unterirdischen Wassers ist die Abstands-(Fliess)geschwindigkeit, die definiert ist durch das Verhaeltnis aus dem Abstand und der wahren Fliesszeit zwischen zwei in Bewegungsrichtung gelegenen Punkten, durch Tracermethoden zu bestimmen. (orig.)

  20. Die Krakauer Kirche von Karmeliten und Karmelitaninnen

    Directory of Open Access Journals (Sweden)

    Józef Szymon Wronski

    2004-12-01

    Full Text Available 1. Die Klosterkirche der unbeschuhten Karmelitinnen Zum Heiligen Josef. Ein glücklicher Auftakt und somit die charakteristische Einführung in das 20. Jh. für den Kirchenbau von Krakau war die Errichtung der Karmeliterinnen St. Josephs-Kirche an der Lobzowska-Straße 40, in der die Architekten (Tadeusz Stryjeński (1849-1943 - Projektant der Kirche und Franciszek Mączyński (1874-1947 - Ausführer des Bauprojektes mit eigenen Verbesserungen die historisch- eklektizistischen Formen d.h. die mittelalterlichen Formen vor allem des sog. Übergangsstils vereinfachten. Die Kirche, die in den Jahren 1903-1905 errichtet wurde, steht inmitten vom Baukomplex des Klosters, dessen Grundriss das Quadrat ist49. Der Kirchenbau ist ein dem Gesamtbau des Klosters eingefügter Längsraum. Hinter dem Chor liegt das Oratorium des Konvents. Das Material Backstein (mit Verwendung von Stein erinnert an die Baukunst eines der besten Architekten jener Zeit, nämlich Teodor Talowskis (1857-1910, der viele Kirchen in Südpolen, aber auch viele Bürgerhäuser nicht nur in Krakau im ausgehenden 19. Jh. baute. Die Architektur der Karmeliterinnen St. Josephs-Kirche ist immer noch im Malerischen begriffen. Aber die Vereinfachung der historischen Formen führt zu ihrer „Beruhigung” und dadurch zur Wuchtigkeit des Ausdrucks. Bemerkenswert ist die in dieser Zeit (in der Anlage noch seltene ausgewogene Proportionierung des Baukörpers. Das methodische Prinzip jener Zeit ist der Kontrast. Im Kontrast zu den gedrungenen und wuchtigen Formen des Baukörpers stehen z.B. die sich verjüngenden obeliskenförmigen und pylonenartigen Türmchen, die nicht nur die Eingangsfassade der Kirche flankieren, sondern auch an den Ecken des Querhauses der Kirche stehen. Die ingravierten weißen Steine an der Fassade in der Zahl von Zehn erinnern an das Gebot des Karmelterinnenordens: Bete täglich den Rosenkranz und sind zugleich ein Vanitativmotiv. 2. Die Klosterkirche der unbeschuhten

  1. Von Neumann's quantization of general relativity

    Science.gov (United States)

    Arbuzov, A. B.; Cherny, A. Yu.; Cirilo-Lombardo, D. J.; Nazmitdinov, R. G.; Han, Nguyen Suan; Pavlov, A. E.; Pervushin, V. N.; Zakharov, A. F.

    2017-05-01

    Von Neumann's procedure is applied to quantizing general relativity. Initial data for dynamical variables in the Planck epoch, where the Hubble parameter value coincided with the Planck mass are quantized. These initial data are defined in terms of the Fock orthogonal simplex in the tangent Minkowski spacetime and the Dirac conformal interval. The Einstein cosmological principle is used to average the logarithm of the determinant of the spatial metric over the spatial volume of the visible Universe. The splitting of general coordinate transformations into diffeomorphisms and transformations of the initial data is introduced. In accordance with von Neumann's procedure, the vacuum state is treated is a quantum ensemble that is degenerate in quantum numbers of nonvacuum states. The distribution of the vacuum state leads to the Casimir effect in gravidynamics in just the same way as in electrodynamics. The generating functional for perturbation theory in gravidynamics is found by solving the quantum energy constraint. The applicability range of gravidynamics is discussed along with the possibility of employing this theory to interpret modern observational data.

  2. Translational medicine advances in von Willebrand disease.

    Science.gov (United States)

    Lillicrap, D

    2013-06-01

    Following the recognition of von Willebrand disease (VWD) in 1926 and the cloning of the gene for von Willebrand factor (VWF) in 1985, significant advances have been made in our fundamental knowledge of both the disease and the protein. Some of this new knowledge has also begun to impact the clinical management of VWD. First, the progressive increase in our understanding of the molecular genetic basis of VWD has resulted in rational applications of molecular testing to complement the current range of phenotypic tests for VWD. These molecular genetic strategies are most effectively directed at the prenatal diagnosis of type 3 VWD and confirmatory testing for types 2B and 2N disease. In contrast, the use of molecular testing to clarify the diagnosis of type 1 VWD is of marginal benefit, at best. In terms of VWD therapies, a new recombinant VWF concentrate has recently completed successful clinical trials and is now awaiting more widespread application. There have even been some preclinical successes with VWF gene transfer although the clinical rationale for this therapeutic strategy needs careful consideration. Much more remains to be learnt about the biology of VWF and further translational advances for the enhancement of VWD care will inevitably be realized. © 2013 International Society on Thrombosis and Haemostasis.

  3. Entwicklung von Nickel-Trägerkatalysatoren für die Methanisierung von Kohlenstoffdioxid unter Anwendung von Parallelpräparation und statistischer Versuchsplanung

    OpenAIRE

    Thomys, Oliver Dieter

    2017-01-01

    Die Methanisierung von Kohlenstoffdioxid (Sabatier-Reaktion) gilt als aussichtsreiche Technologie für die chemische Speicherung überschüssigen elektrischen Stroms aus erneuerbaren Energien. Diese Arbeit befasst sich mit der Präparation von Nickel-Trägerkatalysatoren mit hoher Niedrigtemperatur-Aktivität und Langzeitstabilität. Durch Parallelsynthese-Konzepte und Methoden der statistischen Versuchsplanung konnten entsprechende Katalysatoren mit niedriger Metallbeladung präpariert werden, deren...

  4. Alexander von Humboldt in Daniel Kehlmanns Welt

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2012-12-01

    Full Text Available Zusammenfassung Wie stark sich im Verlauf des zurückliegenden Vierteljahrhunderts der Bekanntheitsgrad Alexander von Humboldts in der deutschsprachigen Öffentlichkeit verändert hat, zeigen nicht nur Fernsehumfragen zu den berühmtesten Deutschen, in denen Alexander von Humboldt mittlerweile figuriert, oder Fernsehserien, die über aktuelle Expeditionen berichten und auf Humboldts Namen zurückgreifen. Am deutlichsten vielleicht belegt dies der enorme Erfolg von Daniel Kehlmanns Roman Die Vermessung der Welt, der ohne die zuvor skizzierte Entwicklung nicht denkbar gewesen wäre. Es ist vor diesem Hintergrund nicht nur reizvoll, sondern aufschlußreich, sich mit dem großen Erfolg dieses kleinen Romans zu beschäftigen. Worum geht es in Die Vermessung der Welt? Und wie läßt sich das „Phänomen Kehlmann“ aus etwas größerer Distanz erklären? Abstract In the last 25 years, Alexander von Humboldt‘s popularity has radically changed in the german-speaking public opinion. Proof of this are not only television surveys about the most famous germans - in which Alexander von Humboldt now regularly figures - or television series about contemporary expeditions, which constantly refer to Humboldt‘s name; perhaps what most clearly verifies this change is the great success of Daniel Kehlmann‘s novel Die Vermessung der Welt. Without the recent developments outlined above, this novel‘s degree of impact would have been unimaginable. To study the great success of this text against this backdrop is not only attractive, but also revealing. What is Die Vermessung der Welt really about? And how can we explain the „Kehlmann phenomenon“ from a greater distance? Resumen La popularidad de Alejandro de Humboldt ha cambiado profundamente dentro del último cuarto de siglo en la opinión pública de habla alemana. Prueba de esto son no sólo las encuestas televisivas sobre los alemanes más famosos, dentro de las cuales figura en estos momentos Alejandro

  5. Análise fitoquímica e atividade fotoprotetora de extrato etanólico de Euphorbia tirucalli Linneau (Euphorbiaceae

    Directory of Open Access Journals (Sweden)

    J.F.F ORLANDA

    2015-01-01

    Full Text Available RESUMO Euphorbia tirucalli Linneau, conhecida popularmente como “avelós”, “cachorro pelado” ou “pau-pelado”, é utilizada na medicina popular para o tratamento de câncer, antibiótico e antivirótico. As plantas medicinais são, frequentemente, utilizadas com o intuito de substituir ou auxiliar as terapias convencionais no tratamento de várias doenças, inclusive para evitar os malefícios causados por radiações ultravioletas. Com isso, o objetivo desta pesquisa foi avaliar o potencial fotoprotetor e a triagem fitoquímica do extrato etanólico das partes aéreas de avelós. A atividade fotoprotetora foi avaliada por meio de ensaios in vitro segundo o método adaptado de Mansur, utilizando extrato etanólico das partes aéreas. Os resultados obtidos mostraram que o estudo fitoquímico evidenciou a presença de açúcares redutores, alcaloides, fenóis, flavonoides, taninos, saponinas, esteroides e triterpenóides na fração etanólica. O extrato apresentou capacidade antioxidante (EC50 de 16,98 ± 0,35 μg.mL-1, teor de compostos fenólicos de 96,18 ± 1,33 mg EqAG/g e flavonoides de 63,57 ± 2,74 mg EqC/g que podem favorecer a atividade fotoprotetora. Avaliando o fator de proteção solar, pode-se observar que todas as concentrações testadas (0,01 a 0,1 µg.mL-1 apresentaram potencial de fotoproteção da radiação ultravioleta com variação de FPS de 6,05 a 19,84, respectivamente. Esses resultados sugerem que o extrato etanólico de Euphorbia tirucalli Linneau apresenta possível efeito fotoprotetor.

  6. Die Rolle von RANK-Ligand und Osteoprotegerin bei Osteoporose

    Directory of Open Access Journals (Sweden)

    Hofbauer LC

    2004-01-01

    Full Text Available Receptor activator of nuclear factor (NF- κB ligand (RANKL, sein zellulärer Rezeptor RANK und der Decoy-Rezeptor Osteoprotegerin (OPG stellen ein essentielles Zytokinsystem für die Zellbiologie von Osteoklasten dar. Verschiedene Untersuchungen belegen die Bedeutung von Störungen des OPG/RANKL/RANK-Systems bei der Pathogenese metabolischer Knochenerkrankungen. In dieser Arbeit werden die wichtigsten Störungen des OPG/RANKL/RANK-Systems bei verschiedenen Osteoporoseformen dargestellt. Östrogenrezeptor- (ER- Agonisten wie 17 β-Östradiol, Raloxifen und Genistein stimulieren die osteoblastäre Produktion von OPG durch Aktivierung von ER- α in vitro, während Lymphozyten von Patientinnen mit Östrogenmangel RANKL überexprimieren. Die parenterale Gabe von OPG vermag den mit Östrogenmangel assoziierten Knochenverlust im Tiermodell und in einer kleineren klinischen Studie zu verhindern. Glukokortikoide und Immunsuppressiva steigern gleichzeitig die RANKL-Expression und hemmen die OPG-Produktion in osteoblastären Zellen in vitro. Glukokortikoide sind auch in vivo imstande, die OPG-Serumspiegel deutlich zu reduzieren. Dagegen hemmen biomechanische Reize in vitro die RANKL-Produktion und steigern die OPG-Produktion. Ein Fehlen dieser biomechanischen Reize bei längerer Immobilisierung kann daher den RANKL/OPG-Quotienten steigern, während die tierexperimentelle Immobilisierungs-Osteoporose durch die parenterale Gabe von OPG gemildert werden kann.

  7. Drei Dimensionen von filmischem Archivmaterial. Die Untersuchung von Archivfilmen aus der Zeit des Holocaust

    Directory of Open Access Journals (Sweden)

    Tobias Ebbrecht-Hartmann

    2017-04-01

    Full Text Available Filmisches Archivmaterial aus der Zeit des Holocaust ist eine ambivalente Quelle. Daher sind spezifische Ansätze notwendig, um dieses Material zu ‘lesen’. Es geht darum, den besonderen Inhalt der Bilder zu analysieren, den Kontext ihrer Entstehung zu bestimmen, aber auch, ihre spätere Verwendung und Zirkulation in der visuellen Kultur und damit auch ihren wechselnden Status mit einzubeziehen. Am Beispiel ausgewählter Filmfragmente aus dem Warschauer Ghetto und dem Ghetto Theresienstadt skizziert der Artikel einen Ansatz, wie man diese drei Dimensionen von filmischem Archivmaterial analysieren kann und schlägt damit eine entsprechende Historiographie von Archivfilmen aus der Zeit des Holocaust vor.

  8. Modellierung von Angebots- und Nachfrageverhalten zur Analyse von Agrarpolitiken: Theorie, Methoden und empirische Anwendungen

    OpenAIRE

    Henningsen, Arne

    2006-01-01

    Die Analyse der Auswirkungen von Agrarpolitiken ist in der Regel sehr komplex und erfordert eine detaillierte Modellierung des Angebots- und Nachfrageverhaltens im Agrarsektor. Eine empirische Anwendung setzt daher eine angemessene ökonomische Theorie sowie fortgeschrittene quantitative Methoden voraus. Alle neun Aufsätze dieser Dissertation lassen sich in diese Themengebiete einordnen. Zunächst werden die Nachfrage nach Bananen und die Folgen der EU Bananenmarktordnung für deutsche Konsument...

  9. Charakterisierung von Mutanten im Lösungsmittelstoffwechsel von Clostridium acetobutylicum

    OpenAIRE

    Hönicke, Daniel

    2015-01-01

    Im Rahmen dieser Arbeit wurden insgesamt neun durch ClosTron-basierte Mutagenese erhaltene Insertionsmutanten von C. acetobutylicum ATCC 824 einer umfangreichen Charakterisierung unterzogen. Für alle im Batch-Fermentationsmaßstab und/oder in kontinuierlicher Kultur fermentierten Stämme erfolgte eine globale Analyse des Transkriptoms unter Verwendung der DNA-Microarray-Technologie. Für eine Analyse des Acetat- und Aceton-Stoffwechsels wurden Stämme mit einer inaktivierten Phosphotransacetyl...

  10. Informationssuchverhalten als Grundlage für die Gestaltung von Veranstaltungen zum Erwerb von Informationskompetenz

    Directory of Open Access Journals (Sweden)

    Martin Wollschläger-Tigges

    2015-09-01

    Full Text Available Für die Gestaltung bibliothekarischer Veranstaltungen zum Erwerb von Informationskompetenz stellen die bisherigen Ergebnisse und Befunde der Forschung zum Informationssuchverhalten eine wertvolle Grundlage dar, indem bestimmte und v.a. typische Verhaltensmuster, Routinen und Präferenzen im Umgang mit Informationsressourcen und Informationen in konzeptionelle und inhaltliche Anpassungen von IK- Veranstaltungen eingebracht und eingesetzt werden. Das Informationssuchverhalten untersucht sowohl individuelle als auch kollektive Informationsprozesse und Faktoren, die diese maßgeblich beeinflussen. Hierzu werden der gesamte Informationsprozess oder einzelne Abschnitte untersucht, die den Information Need, Seeking und Using (INSU-Prozess bilden. Die Befunde der einzelnen INSU-Prozesses-Einheiten zeigen, dass Faktoren wie Informationsbedarf, Informationsart und -form sowie die Einbindung in übergeordnete Arbeitsprozesse wesentlichen Einfluss auf das Informationssuchverhalten haben. Des Weiteren konnte die ISB-Forschung eine Klassifizierung von Benutzergruppen entwickeln und z.B. Fast Surfers, Broad Scanners und Deep Divers charakterisieren bzw. auch das Bouncing oder Flicking Behavior beschreiben. Hinzu kommen mehrere Modelle, die Informationssuchverhalten und Informationsverhalten in bestimmten Situationen nachbilden und darstellen können.

  11. Tragverhalten von Verbunddübeln unter Zugbelastung

    OpenAIRE

    Appl, Jörg-Jochen

    2009-01-01

    Im Bauwesen werden in zunehmendem Maße Dübel zur Einleitung von Lasten in den erhärteten Beton eingesetzt. Vor allem Befestigungssysteme auf der Grundlage chemischer Mörtel werden vermehrt verwendet. Allerdings fehlte bisher ein genügend genaues Berechnungsmodell zur Bemessung von beliebigen Befestigungen mit Verbunddübeln für unterschiedliche Verankerungstiefen und für verschiedene Verbundfestigkeiten. In der vorliegenden Arbeit wurde das Tragverhalten von Verbundübeln unter Zugbelastung...

  12. A von Bertalanffy growth model with a seasonally varying coefficient

    Science.gov (United States)

    Cloern, James E.; Nichols, Frederic H.

    1978-01-01

    The von Bertalanffy model of body growth is inappropriate for organisms whose growth is restricted to a seasonal period because it assumes that growth rate is invariant with time. Incorporation of a time-varying coefficient significantly improves the capability of the von Bertalanffy equation to describe changing body size of both the bivalve mollusc Macoma balthicain San Francisco Bay and the flathead sole, Hippoglossoides elassodon, in Washington state. This simple modification of the von Bertalanffy model should offer improved predictions of body growth for a variety of other aquatic animals.

  13. Abenteuer Alexander-von-Humboldt-Bibliographie

    Directory of Open Access Journals (Sweden)

    Christian Suckow

    2002-04-01

    Full Text Available Article in German; Abstracts in English and German.The two attempts (1860 and 1872 to compile a bibliography of all works of Alexander von Humboldt have to be regarded as failures. Due to Humboldt’s scientific methods, the contemporary popularity of his writings, and the conditions of book publishing and selling, it has been difficult to achieve an overview of his œuvre. Thus each attempt to write a reliable or at least partially complete bibliography of Humboldt’s works constituted an adventure. Horst Fiedler and Ulrike Leitner have mastered this undertaking. As a result of their efforts over more than two decades, a bibliography of those works by Humboldt which were published in book form appeared in the year 2000.

  14. Johann von Lamont: A Pioneer in Geomagnetism

    Science.gov (United States)

    Soffel, Heinrich

    2006-06-01

    The 200th birthday of John Lamont (1805-1879, Figure 1), a pioneer in the study of geomagnetism, was marked on 13 December 2005. Lamont founded the Munich Geomagnetic Observatory in 1840 and was a member of the group of scientists including Carl Friedrich Gauss, Alexander von Humboldt, Eduard Sabine, Jonas Angstrøm, Humphret Lloyd, Adolf Kupffer, Karl Kreil, and Adolphe Quetelet who composed the Göttingen Magnetic Union. They organized an international network of geomagnetic observatories [Barraclough et al., 1992]. The present knowledge of the geomagnetic field and its secular variation is largely based on the data collected by the global network of geomagnetic observatories during the last 170 years. Lamont's talents and his dedication and enthusiasm for discovery are reflected in the depth and scope of his contributions to a broad variety of natural sciences such as astronomy, meteorology, geomagnetism, and geodesy. However, this article just touches on his merits in geomagnetism.

  15. Bertha von Suttner 1843-1914

    OpenAIRE

    Hoock-Demarle, Marie-Claire; Hessel, Stéphane

    2016-01-01

    Née dans « le monde d'hier » cher à son compatriote Stefan Zweig, morte le 21 juin 1914 à la veille du déclenchement d’une guerre qu’elle appelle Weltkrieg, Bertha von Suttner témoigne d’un parcours hors du commun dans un moment crucial où s’amorcent les conflits générés par les militarismes et les nationalismes menant inexorablement à la catastrophe. Arpenteuse d’Europe, voyageuse du Nouveau Monde, elle voit dans « l’américanisation du monde » une raison de construire dans la paix et la coop...

  16. Modernisation of ventilation systems; Modernisierung von Lueftungsanlagen

    Energy Technology Data Exchange (ETDEWEB)

    Richter, W. [Technische Univ. Dresden (Germany). Inst. fuer Thermodynamik und Technische Gebaeudeausruestung

    1997-12-31

    When redeveloping buildings it is common to use window constructions with air-tight rabbets which obviate the inflow of fresh air almost entirely. This leads to the well-known structural-physics and hygienic consequences. As an added effect, the distinctly enhanced thermal insulation results in changes in dynamic heat loss. The paper focuses on the issues of how to safeguard the inflow of fresh air, and the heating capacity of radiators. (MSK) [Deutsch] Da die bei Gebaeudesanierungen eingesetzten fugendichten Fensterkonstruktionen die Nachstroemmoeglichkeiten fuer die Zuluft fast ganz unterbinden, fuehrt das zu den bekannten bauphysikalischen und hygienischen Konsequenzen. Dazu kommen veraenderte dynamische Waermverlustverhaeltnisse aufgrund der deutlich verbesserten Waermedaemmung. Im Folgenden wird schwerpunktmaessig auf die Probleme Zuluftsicherung und Waermeleistung von Heizkoerpern eingegangen.

  17. Hepatische Effekte von Wachstumshormon auf den Glukosestoffwechsel

    Directory of Open Access Journals (Sweden)

    Rufinatscha K

    2015-01-01

    Full Text Available Untherapierter Wachstumshormonmangel im Erwachsenenalter (AGHD ist mit viszeraler Adipositas, Dyslipidämie, Insulinresistenz und Fettleber verbunden. Interessanterweise finden sich viele der AGHD-Merkmale auch bei Patienten mit metabolischem Syndrom. Die nichtalkoholische Fettlebererkrankung (NAFLD gilt als hepatische Manifestation des metabolischen Syndroms. In einigen Studien wurden bei Patienten mit NAFLD verminderte Konzentrationen von zirkulierendem IGF-1, dessen Synthese zu einem großen Teil durch Wachstumshormon (GH reguliert wird, beschrieben. Mäuse, welche eine hepatische Wachstumshormondefizienz aufweisen, zeigen zahlreiche phänotypische Charakteristika des metabolischen Syndroms, unter anderen auch eine Fettlebererkrankung. Dies legt einen Zusammenhang zwischen dem Wachstumshormon und der Entstehung einer NAFLD nahe. Ziel unserer Studie ist es, in einem Zellkulturmodell die Effekte des Wachstumshormons auf den intrazellulären Glukosestoffwechsel näher zu untersuchen. Im Detail sollen Auswirkungen einer verminderten Wachstumshormonrezeptorexpression auf den Insulinsignaltransduktionsweg, den Glykogengehalt und auf Schlüsselenzyme der Glukoneogenese untersucht werden. Präliminäre Daten zeigen, dass eine verminderte Wachstumshormonrezeptorexpression mit intrazellulären Veränderungen des hepatischen Glukosestoffwechsels verbunden ist. Die verminderte Insulinsensitivität könnte auf Alterationen im Insulinsignaltransduktionsweg und Änderungen der Glukoneogenese zurückzuführen sein. Diese präliminären Daten weisen darauf hin, dass Wachstumshormon einen direkten Einfluss auf den Glukosestoffwechsel in der Leber hat. Zudem legen sie nahe, dass Veränderungen im Wachstumshormonstoffwechsel einen wichtigen pathophysiologischen Mechanismus in der Entstehung der Fettlebererkrankung bei Patienten mit metabolischem Syndrom darstellen könnten. Der folgende Artikel soll einen kurzen Überblick über die Effekte von Wachstumshormon

  18. VON WILLEBRAND DISEASE: DIAGNOSIS AND TREATMENT

    Directory of Open Access Journals (Sweden)

    Majda Benedik Dolničar

    2004-12-01

    Full Text Available Background. Von Willebrand disease (VWD is a most frequently inborn bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor (VWF. VWF promotes platelet-vessel wall (adhesion and plateletplatelet interaction (aggregation. It is also the carrier for factor VIII (F VIII in plasma. A deficiency of VWF may results in impairment of both, primary and secondary haemostasis. Therefore, patients with VWD can have bleeding symptoms typical fot the defect in primary haemostasis (mucocutaneous haemorrhages. In severe deficiency of VWF there are also haemarthroses and haematomas typical for patients with coagulation defects. Several types and subtypes of VWD have been described. The diagnosis is based on measurements of VWF concentration and activity and F VIII activity in plasma. The tests identifying VWD subtypes are ristocetin induced platelet agglutination (RIPA, multimeric analysis of VWF and measurement of the binding of VWF to F VIII.Conclusions. Due to heterogeneity of VWF defects, the correct diagnosis of types and subtypes is sometimes difficult but is important for appropriate treatment. There are two main therapeutic options for patients with VWD: desmopressin and blood derived concentrates of F VIII/VWF. In certain cases antifibrinolytics and hormones can be suitable treatment. Desmopressin is the treatment of choice in patients with type 1 VWD. It raises endogenous F VIII and VWF and thereby corrects the intrinsic coagulation defect as well as the prolonged bleeding time (BT or closure time (CT-PFA100 in most type 1 VWD patients. In type 3 and in the majority of type 2 patients desmopressin is not effective and it is necessary to use concentrates containing F VIII and VWF. These are always effective in raising of F VIII activity, whereas the BT/CT may not be completely corrected, but the normalisation of the BT/CT is not always necessary.

  19. Effect of Niclosamide (Bayluscide WP 70 (R, Anacardium occidentale hexane extract and Euphorbia splendens latex on behavior of Biomphalaria glabrata (Say, 1818, under laboratory conditions

    Directory of Open Access Journals (Sweden)

    Pedro Jurberg

    1995-04-01

    Full Text Available The repellent effect of the molluscicides Niclosamide (Bayluscide WP 70 (R, Anacardium occidentale and the latex of Euphorbia splendens on Biomphalaria glabrata was observed through the investigation of the occurrence of escape behavior among molluscs that were exposed to dosages lower than the LD 50. The total number of individuals out of water among the surviving snails in the control group provided a "Natural Escape Index". The comparison between this total and the total number of surviving snails in each group exposed to the different dosages of the molluscicides after 24 hr provided the "Molluscicide Escape Index" and the detection of a "Repellency Range" to these snails. The escape indexes for Niclosamide, A. occidentale and E. splendens were 10, 6.22 and 6.44 respectively. Repellency occurred at the following concentration ranges: 0.01, 0.02 and 0.03 ppm Bayluscide, 0.1, 0.2 and 0.3 ppm A. occidentale and 0.05, 0.10, 0.15 and 0.20 ppm E. splendens. The Natural Escape Index obtained in the control group was zero.

  20. In situ chlorophyll fluorescence kinetics as a tool to quantify effects on photosynthesis in Euphorbia cyparissias by a parasitic infection of the rust fungus Uromyces pisi.

    Science.gov (United States)

    Zhori, Alba; Meco, Marjol; Brandl, Helmut; Bachofen, Reinhard

    2015-11-21

    Photosynthesis is the key process for plant growth and development. The determination of chlorophyll fluorescence kinetics allows the quantification of effects on photosynthetic processes triggered by environmental stress factors such as, e.g., the infection by fungal phytopathogens. The technique is non-invasive, rapid and well suited for experimental field work. Healthy and Uromyces-infected plants of Euphorbia cyparissias were monitored directly in situ in the field using rapid fluorescence kinetics. Non-infected healthy plants show a typical maximum value for the relative variable fluorescence Fv/Fm of around 0.8 with occasional variation between the leaves from the plant top towards the base, while infected plants exhibited a strong gradient to low values at the base. The photosynthetic performance index (PI) showed a higher heterogeneity within the leaves in both plant types. The non-invasive and rapid measurement of chlorophyll fluorescence induction allows characterizing the photosynthetic capacity of healthy and infected plants and of parts of them directly in the field. The PI, is highly sensitive not only concerning infection, but also towards other local environmental influences.

  1. C/sub 4/ photosynthesis in Euphorbia degeneri and E. remyi: a comparison of photosynthetic carbon metabolism in leaves, callus cultures and regenerated plants

    Energy Technology Data Exchange (ETDEWEB)

    Ruzin, S.E.

    1984-04-01

    Based on analysis of /sup 14/CO/sub 2/ fixation kinetics and assays of enzymes related to C/sub 4/ metabolism (NAD-ME, NADP-ME, NAD-MDH, NADP-MDH, AST, ALT), leaves and regenerated plants of Euphorbia degeneri exhibit a modified NADP-ME-type photosynthesis. Apparently, both aspartate and malate are used for transport of CO/sub 2/ to bundle sheath cells. Callus grown on either non-shoot-forming or shoot-forming media fixes CO/sub 2/ into RPP-cycle intermediates and sucrose, as well as malate and aspartate. /sup 14/CO/sub 2/ pulse/chase kinetics show no significant loss of label from C/sub 4/ acids throughout a one minute chase. Analysis of PEPCase revealed the presence of 2 isoenzymes in both leaf and regenerated plant tissues (K/sub m/ (PEP) = 0.080 and 0.550) but only one isoenzyme in callus (K/sub m/ = 0.100). It appears that C/sub 4/ photosynthesis does not occur in callus derived from this C/sub 4/ dicot but is regenerated concomitant with shoot regeneration, and ..beta..-carboxylation of PEP in callus, mediated by the low K/sub m/ isoenzyme of PEPCase, produces C/sub 4/ acids that are not involved in the CO/sub 2/ shuttle mechanism characteristic of C/sub 4/ photosynthesis. 161 references, 19 figures, 12 tables.

  2. Effects of coal-smoke pollutants from different sources on the growth, chlorophyll content, stem anatomy and cuticular of Euphorbia hirta L

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, M.C.; Ghouse, A.K.M.

    1987-01-01

    Variations occurred in the growth, assimilate partitioning, chlorophyll content, stem anatomy and leaf cuticular traits of Euphorbia hirta L. on longterm exposure to coal-smoke pollutants prevailing at two sites, one situated close to a railway loco shed (site B) and another in the vicinity of a thermal power plant (site C). The Botanical Garden of Aligarh Muslim University was considered as a control site (A). Site C possessed a greater load of coal-smoke pollutants than site B. The present study had shown that coal-smoke pollutants have led to a decrease in plant height, jeopardised the production of leaves and enhanced their fall, and caused a reduction in leaf area, leading to decreases of the total photosynthetic area of the plants, with increasing pollution load. The losses incurred in chlorophyll a were relatively more than chlorophyll b and, as a result, the total chlorophyll contents of leaves were decreased in polluted plants. The dry weights of stems, roots and leaves were decreased to different degrees, whereas the shoot/root dry weight ratio was found to increase in the polluted environment. The growth of stem cortex and pith was slightly affected on site B, but showed significant decreases on site C, due to a greater load of pollutants. Decreased area of xylem tissue was found to couple with an increasing number of vessels of reduced sizes. The stomatal density, pore size and index showed decreases. 20 refs., 4 tabs.

  3. Phytochemical analysis, antimicrobial and antioxidant activities of Euphorbia golondrina L.C. Wheeler (Euphorbiaceae Juss.): an unexplored medicinal herb reported from Cameroon.

    Science.gov (United States)

    Ndam, Lawrence Monah; Mih, Afui Mathias; Tening, Aaron Suh; Fongod, Augustina Genla Nwana; Temenu, Nkegua Anna; Fujii, Yoshiharu

    2016-01-01

    This study aimed at determining the phytochemical constituents of Euphorbia golondrina L.C. Wheeler, an alien invasive medicinal herb that is used for the treatment of gastroenteritis related ailments, diabetes, conjunctivitis, gastritis, enterocolitis, tonsillitis, vaginitis, hemorrhoids, prostatism, warts and painful swellings by the Mundani people of the mount Bambouto Caldera in SouthWestern Cameroon, and to evaluate its in vitro antimicrobial and antioxidant activities. Susceptibility testing by agar well diffusion assay revealed good antibacterial activity with inhibition zone diameter of 20 ± 1.1 mm against Bacillus cereus followed by Staphylococcus aureus with inhibition zone diameter of 17 ± 1.6 mm which was significantly lower (P activity of E. golondrina was higher than that of gallic acid and BHT at concentrations greater than 0.1 and 0.2 mg/mL respectively while at all concentrations, nitric oxide scavenging activity was higher than those of both rutin and vitamin C. GC-MS profile of E. golondrina steam distilled volatiles revealed that the plant has potent phytoconstituent classes such as sesquiterpenes, monoterpenes, alkaloids, phenolics and aromatic hydrocarbons. Among the 30 compounds identified, caryophyllene oxide (14.16 %), camphor (9.41 %) and phytol (5.75 %) were the major compounds. Further structural characterisation based on (1)H and (13)C NMR is required to demonstrate structural integrity including correct stereochemistry. The current study partially justifies the ethnomedicinal uses of E. golondrina in Cameroon.

  4. Development of matrix solid-phase dispersion coupled with high-performance liquid chromatography for determination of jolkinolide A and jolkinolide B in Euphorbia fischeriana Steud.

    Science.gov (United States)

    Cai, Defu; Zhai, Weiyu; Zhang, Qi; Liu, Jianhua; Sun, Yu; Liu, Lei; Liu, Jicheng

    2017-08-01

    A novel and simple method was established for the extraction and determination of jolkinolide A and B in Euphorbia fischeriana Steud. using matrix solid-phase dispersion (MSPD) extraction and high-performance liquid chromatography (HPLC). The optimised conditions for the MSPD extraction were determined to be that silica gel was served as dispersant, the mass ratio of sample to silica gel was selected to be 1:4, and 5 mL of acetonitrile was used as elution solvent. The method exhibited a good performance in terms of linearity (r2 ≥ 0.9997) and the limits of detection in the range of 0.052-0.065 μg mL-1. The recoveries were in the range of 90.2-98.9% with relative standard deviations (RSDs) ranging from 1.3 to 3.5%. The extraction efficiencies obtained by the MSPD were higher than other extraction method with less cost of sample and solvent. At last, the optimised method was applied for analysing real samples.

  5. [Action of Euphorbia humifusa effective fraction on membrane biosynthesis and the gene expression of proteases MEP and SUB of Trichophyton rubrum].

    Science.gov (United States)

    Li, Zhi-Jian; Zhao, Ming-Yue; Dawuti, Gulnar; Aibai, Silafu

    2014-02-01

    This study is to investigate the effect of Euphorbia humifusa effective fraction (EHEF) on the CYP51 enzyme activity, the lanosterol content and the MEP, SUB gene expression of Trichophyton rubrum. Trichophyton rubrum was treated by EHEF for 7 days at 26 degrees C. The activity of CYP51 enzyme of Trichophyton rubrum in the cell membrane was determined by using ELISA kit, and the lanosterol content was investigated by using high performance liquid chromatography (HPLC), and the MEP, SUB gene expression of Trichophyton rubrum was detected with the reverse transcription polymerase chain reaction (RT-PCR) method. Results showed that EHEF can decrease the membrane CYP51 enzyme activity, and it also can accumulate the fungal lanosterol in a dose-dependent manner, and it also can decrease the gene expression of MEP and SUB. The antifungal mechanism of EHEF may be related to the inhibition on CYP51 enzyme activity, and to the effects on fungal cell membrane ergosterol biosynthesis. It may also play an antifungal effect by inhibiting the MEP, SUB gene expression of fungal proteases.

  6. Euphorbia milii-native bacteria interactions under airborne formaldehyde stress: Effect of epiphyte and endophyte inoculation in relation to IAA, ethylene and ROS levels.

    Science.gov (United States)

    Khaksar, Gholamreza; Treesubsuntorn, Chairat; Thiravetyan, Paitip

    2017-02-01

    Better understanding of plant-bacteria interactions under stress is of the prime importance for enhancing airborne pollutant phytoremediation. No studies have investigated plant-epiphyte interactions compared to plant-endophyte interactions under airborne formaldehyde stress in terms of plant Indole-3-acetic acid (IAA), ethylene, reactive oxygen species (ROS) levels and pollutant removal efficiency. Euphorbia milii was inoculated with native plant growth-promoting (PGP) endophytic and epiphytic isolates individually to investigate plant-endophyte compared to plant-epiphyte interactions under continuous formaldehyde fumigation. Under airborne formaldehyde stress, endophyte interacts with its host plant closely and provides higher levels of IAA which protected the plant against formaldehyde phytotoxicity by lowering intracellular ROS, ethylene levels and maintaining shoot epiphytic community; hence, higher pollutant removal. However, plant-epiphyte interactions could not provide enough IAA to confer protection against formaldehyde stress; thus, increased ROS and ethylene levels, large decrease in shoot epiphytic population and lower pollutant removal although epiphyte contacts with airborne pollutant directly (has greater access to gaseous formaldehyde). Endophyte-inoculated plant synthesized more tryptophan as a signaling molecule for its associated bacteria to produce IAA compared to the epiphyte-inoculated one. Under stress, PGP endophyte interacts with its host closely; thus, better protection against stress and higher pollutant removal compared to epiphyte which has limited interactions with the host plant; hence, lower pollutant removal. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  7. Von Krahli Teatri lavastus pääses tippfestivalile

    Index Scriptorium Estoniae

    1999-01-01

    Von Krahli Teatri uuendatud lavastus "Eesti mängud. Pulm" esietendub festivalil Theater Der Welt Berliinis. Peeter Jalaka multimeediaetendus Eesti ajaloost ja traditsioonidest osaleb ka suveteatrite festivalil Hamburgis, seejärel antakse kuus etendust Amsterdamis

  8. La actualidad del pensamiento de Carl von Clausewitz

    National Research Council Canada - National Science Library

    Borrero Mansilla, Armando

    2003-01-01

    The article presents the validity of the thought of Carl von Clausewitz, which application, beyond the wars among national States, can be extended to the analysis of the confrontation among political...

  9. Lexikon lesbischer Frauen im Film von Daniela Sobek

    Directory of Open Access Journals (Sweden)

    Karin Windt

    2002-03-01

    Full Text Available Das Lexikon stellt ein neues Basiswerk über lesbische Figuren im Film dar. Neben zahlreichen Artikeln von Anbeginn der Filmgeschichte bis heute gibt es Features über bekannte Schauspielerinnen und lesbische role models.

  10. Magnus Georg von Paucker (1787-1855) / Eckhard Spring

    Index Scriptorium Estoniae

    Spring, Eckhard

    2013-01-01

    Eestis sündinud ja Tartu Ülikoolis õppinud silmapaistvast baltisaksa teadlasest ja tema lapselapsest Alexandrine Pauckerist. 23. novembril 2012 Jelgavas/Mitaus toimunud Magnus Georg von Pauckerile pühendatud teaduskonverentsist

  11. Von Krahli Teater toob Eestisse erakordse auhinna / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2004-01-01

    Bessie-auhinna puhul, millega New Yorgis pärjati Von Krahli Teatri lavastust "Luikede järv." Mõjukuselt on seda võrreldud Broadway teatriauhinna Tonyga. Lisatud lühiandmed P. Jalaka ja S. Pepeljajevi kohta

  12. Politische Bildung im Kontext von Regierung, Unterricht und Zucht

    National Research Council Canada - National Science Library

    Thomas Rucker

    2014-01-01

    .... In diesem Beitrag wird zu zeigen versucht, dass Herbart die Unterstützung politischer Bildung als eine Aufgabe von Regierung, Unterricht und Zucht bestimmt und in seinem Werk wichtige „Bausteine...

  13. Revascularization Operation for Moyamoya Disease with Concurrent von Willebrand Disease.

    Science.gov (United States)

    Miki, Kenji; Arimura, Koichi; Nishimura, Ataru; Yoshimoto, Koji; Sayama, Tetsuro; Iihara, Koji

    2017-12-01

    Although extracranial-intracranial (EC-IC) bypass is an effective treatment strategy for symptomatic moyamoya disease, surgeons need to be cautious regarding the possibility of postoperative hemorrhagic complications in patients with a concurrent coagulation disorder. Here, we describe a case of EC-IC bypass for moyamoya disease concurrent with von Willebrand disease type 1. Following perioperative replacement of the von Willebrand factor, the patient showed an uneventful and uncomplicated clinical course. This is the first reported case of EC-IC bypass being performed for moyamoya disease in a patient with concurrent von Willebrand disease. We emphasize the importance of appropriate management with replacement of the von Willebrand factor during the perioperative period to avoid hemorrhagic complications. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Die zentrale Wirkung von Candesartan in der Schlaganfalltherapie

    OpenAIRE

    Maydowski, Katja

    2011-01-01

    Ziel der vorliegenden Arbeit war es, die Auswirkungen des AT1-Blockers Candesartan auf einen ischämischen Insult durch eine rein zentrale AT1-Blockade am Tiermodell mit direkter intracerebroventrikulärer Applikation von Candesartan zu untersuchen.

  15. Zur sportlichen Laufbahn von Marathonläufern

    OpenAIRE

    Rümmele, Edgar

    1984-01-01

    Zur sportlichen Laufbahn von Marathonläufern : e. Beitr. zur Psychologie d. Marathonläufers. - Thun u.a. : Deutsch, 1984. - 253, 14 S. - Zugl.: Tübingen, Univ., Diss. - (Beiträge zur Sportwissenschaft ; 1)

  16. Warum das Controlling den systematischen Einsatz von Simulationen vorantreiben sollte

    DEFF Research Database (Denmark)

    Spitzner, Jan; Schneider, Melanie L.

    2017-01-01

    Simulationen werden in der Unternehmenssteuerung heutzutage noch nicht systematisch eingesetzt. Dass sich jedoch die existierenden Hemmnisse durchaus überwinden lassen, legen die Antworten von Studienteilnehmern nahe, die Simulationen häufig einsetzen. Dabei kann Controlling eine Vorreiterrolle e...

  17. Von Krahli Teater viis Helsingisse kaks menulavastust / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    Von Krahli Teater esineb 29. nov. Helsingis "Baltic Circle" festivalil lavastustega "Luikede järv" ja "Taksojuhid". Tutvustatakse lühidalt ka paari olulisemat soome lavastust ("Puksiirabi" ja "Hamlet"), mis tulevad festivalil esitamisele

  18. Zur Dialektik von Soft Skills und fachlicher Kompetenz

    OpenAIRE

    Jendrowiak, Hans-Werner

    2010-01-01

    [Der Autor stellt folgende Thesen zur Dialektik von Soft Skills und fachlicher Bildung auf:] 1. Soft Skills sind normale Bildungskategorien und Teil einer Allgemeinen Bildung. […] 2. Soft Skills sind als personalgebundene Kriterien auch immer schon Gegenstand bildungstheoretischer Debatten. […] 3. Soft Skills ist eine trendorientierte Bezeichnung für Bildung. […] 4. Soft Skills sind Ausdruck von Vorstellungen, Ideen und Theorien (Schulkultur, Unternehmenskultur, Unternehmensphilosophie). 5. S...

  19. Behandlung von Cybermobbing durch die Soziale Arbeit in der Schule

    OpenAIRE

    Dill, Irina; Wahl, Lisa

    2015-01-01

    Gegenstand dieser Arbeit ist die Behandlung von Cybermobbing durch die Soziale Arbeit in der Schule. Cybermobbing ist eine neuere Form von schulischer Gewalt und verlangt nach neuen Formen der Beratung und Intervention der Sozialen Arbeit in der Schule. Anhand einer Literaturrecherche gehen die Autorinnen Lisa Wahl und Irina Dill der Frage nach, inwiefern die Soziale Arbeit in der Schule Cybermobbing behandeln kann. Die Konzipierung der Sozialen Arbeit in der Schule fundiert primär auf dem Bu...

  20. Zusammenhang von Prozess, Mikrostruktur, Eigenspannungen und Eigenschaften bei Aluminiumverbundwerkstoffen

    OpenAIRE

    Kachold, Franziska

    2016-01-01

    Wo die mechanische Leistungsfähigkeit von monolithischen Materialien an ihre Grenzen stößt, bieten Verbundwerkstoffe neue Perspektiven. Besonders wenn hohe Festigkeit oder Steifigkeit bei gleichzeitig niedrigem spezifischen Gewicht gefordert ist, kommen Faserverbundwerkstoffe zum Einsatz. Faserverstärkte Polymere existieren bereits seit ca. 1900 und werden heute für ein breites Spektrum von Bauteilen und Produkten im Automobil-, Flugzeug- und auch Sportgerätebau verwendet. Die geringe T...

  1. Von Neumann's impossibility proof: Mathematics in the service of rhetorics

    Science.gov (United States)

    Dieks, Dennis

    2017-11-01

    According to what has become a standard history of quantum mechanics, in 1932 von Neumann persuaded the physics community that hidden variables are impossible as a matter of principle, after which leading proponents of the Copenhagen interpretation put the situation to good use by arguing that the completeness of quantum mechanics was undeniable. This state of affairs lasted, so the story continues, until Bell in 1966 exposed von Neumann's proof as obviously wrong. The realization that von Neumann's proof was fallacious then rehabilitated hidden variables and made serious foundational research possible again. It is often added in recent accounts that von Neumann's error had been spotted almost immediately by Grete Hermann, but that her discovery was of no effect due to the dominant Copenhagen Zeitgeist. We shall attempt to tell a story that is more historically accurate and less ideologically charged. Most importantly, von Neumann never claimed to have shown the impossibility of hidden variables tout court, but argued that hidden-variable theories must possess a structure that deviates fundamentally from that of quantum mechanics. Both Hermann and Bell appear to have missed this point; moreover, both raised unjustified technical objections to the proof. Von Neumann's argument was basically that hidden-variables schemes must violate the ;quantum principle; that physical quantities are to be represented by operators in a Hilbert space. As a consequence, hidden-variables schemes, though possible in principle, necessarily exhibit a certain kind of contextuality. As we shall illustrate, early reactions to Bohm's theory are in agreement with this account. Leading physicists pointed out that Bohm's theory has the strange feature that pre-existing particle properties do not generally reveal themselves in measurements, in accordance with von Neumann's result. They did not conclude that the ;impossible was done; and that von Neumann had been shown wrong.

  2. Möglichkeiten und Grenzen von Social Media Marketing

    OpenAIRE

    Kreutzer, Ralf T.; Hinz, Jule

    2010-01-01

    In diesem Arbeitspapier wird das Konzept des Social Media Marketing theoretisch dargestellt und seine Möglichkeiten und Grenzen analysiert. Dabei werden die einzelnen Instrumente des Social Media Marketings sowie die verschiedenen Nutzertypen erläutert und auf die Erfolgsmessung von Methoden des Social Media Marketings eingegangen. Schließlich wird an den Beispielen HUGO BOSS, Starbucks und Nestlé auf die Umsetzung von Maßnahmen des Social Media Marketings eingegangen und aufgezeigt, welche E...

  3. Rekonstruktion von Gletscherschwankungen mit Hilfe fossiler Hölzer

    OpenAIRE

    Holzhauser, H.

    1984-01-01

    Im vorliegenden Artikel wird gezeigt, wie mit Hilfe von fossilen Hölzern aus dem Gletschervorfeld minimale Gletscherausdehnungen und Gletschervorstöße erfaßt werden können. Einige zeitgenössische Berichte und Zeichnungen aus der Zeit um 1850, als die Alpengletscher ihren letzten neuzeitlichen Hochstand erreichten, sollen veranschaulichen, wie Gletscher in bewaldetes Gebiet vordrangen und Bäume umdrückten. Es wird im weiteren kurz auf die Lage von fossilem Holz im Gletschervo...

  4. Nationale Kapitalanlagengarantien als Instrumente zur Förderung von Direktinvestitionen

    OpenAIRE

    Stern, Thomas

    1988-01-01

    Wegen ihres hohen entwicklungspolitischen Stellenwertes ist die Steigerung von Direktinvestitionen als langfristiges Instrument zur Verbesserung der Verschuldenssituation der Länder der Dritten Welt anerkannt. Trotz dieser Erkenntnis blieben die Direktinvestitionen in Richtung der Entwicklungsländer in den letzten fünf Jahren hinter den Erwartungen zurück und erreichten lediglich einen Anteil von ca. 12 % an den Gesamtkapitalströmen. Wichtige Motive für die Zurückhaltung der Investoren in die...

  5. Kommunale Versorgung, Verortung und Steuerung von Risiken psychischer Gesundheit

    OpenAIRE

    Warner, Joanne

    2006-01-01

    Das Risikokonzept ist heute zentral für alle Bereiche von gesundheitlicher und sozialer Wohlfahrt in Großbritannien. Im Bereich psychischer Gesundheit und insbesondere seit den Maßnahmen zur kommunalen Versorgung in den 1990er Jahren kommt dem Konzept jedoch besondere Aufmerksamkeit zu. Dabei kamen bisher vor allem die Risiken in den Blick, die von Personen mit psychischen Erkrankungen oder in psychischer Not ausgehen, aber nicht die Risiken, mit denen diese selbst konfrontiert sind. Der vorl...

  6. Untersuchung der verfahrenstechnischen Potentiale von CO2-Minderungsoptionen

    OpenAIRE

    Geng, Jin

    2017-01-01

    Die vorliegende Arbeit beschäftigt sich mit der Untersuchung der verfahrenstechnischen Potentiale von CO2-Minderungsoptionen. CO2 ist ein Treibhausgas und führt zu Klimaproblemen. Wie erfolgreich der Kampf gegen den Klimawandel ist, hängt stark von den politischen Entscheidungen ab, welche auf internationalen Vereinbarungen und der wirtschaftlichen Situation basieren. Allerdings ist die technische Machbarkeit die Voraussetzung aller Entscheidungen. In der Arbeit wird diskutiert, welches P...

  7. CyLaw-Report V : "Sicherheit von ec-Karten"

    OpenAIRE

    Schmid, Viola

    2008-01-01

    Entscheidung des BGH vom 05.10.2004 - XI ZR 210/03 Die vorliegende Entscheidung des Bundesgerichtshof (BGH) bringt - nach jahrelanger juristischer Diskussion und divergierender Rechtsprechung verschiedener Gerichte - weiteren Aufschluss bei beweis- und haftungsrechtlichen Fragen von ec-Karten. Die besondere Bedeutung bargeldloser Zahlungsverfahren im Bereich von eCommerce, eGovernment etc. machen das Urteil des BGH zu einer für das Cyberlaw interessanten Entscheidung.

  8. Hochtemperaturverhalten von Stahlbetonplatten mit Textilbetonverstärkung

    OpenAIRE

    Hothan, Sascha; Ehlig, Daniel

    2011-01-01

    Die Verwendung von Endlosfilamenten aus Carbon als Bewehrungsmaterial für Beton, sogenannter Textilbeton, bietet die Möglichkeit der Sanierung und der Verstärkung bestehender Stahlbetonkonstruktionen. Dabei muss die Frage nach dem Feuerwiderstand von derart verstärkten Tragwerken beantwortet werden. Aufschluss darüber liefern Brandversuche. Mit Textilbeton verstärkte Stahlbetonplatten haben in Brandversuchen nach der Einheits- Temperaturzeitkurve bei 33 % der Traglast mehr als 60 Minuten stan...

  9. Expression von Wachstumsfaktoren unter Vakuumversiegelungstherapie in chronischen Wunden

    OpenAIRE

    Rosenberg, Birgit

    2012-01-01

    Hintergründe und Zielsetzung Die Vakuumversiegelungsmethode (V.A.C.® = Vac.) ist ein von M. Morykwas und C. Argenta 1988 entwickeltes Verfahren zur Konditionierung von akuten und chronischen Wunden, das sich in den letzten Jahren klinisch etabliert und dessen Anwendungsspektrum kontinuierlich zugenommen hat. In vielen klinischen Studien konnte die Wirksamkeit dieses Therapieverfahrens in der Wundbehandlung nachgewiesen werden, unklar ist jedoch bislang welche physiologischen Veränderungen auf...

  10. Nash y von Neumann: mundos posibles y juegos de lenguaje

    Directory of Open Access Journals (Sweden)

    Salazar , Boris

    2004-06-01

    Full Text Available Este ensayo emplea las nociones de juego de lenguaje y de equivalencia entre juegos para examinar la decisión de John Nash de no jugar el juego coalicional que propuso John von Neumann. El argumento central es que Nash concibió una clase de mundos posibles incompatible con la de von Neumann, y que en el origen de esa divergencia estarían sus distintas nociones de racionalidad.

  11. Entwicklung von Cellulosefaser-Leichtbeton und Untersuchung des bruchmechanischen Verhaltens

    OpenAIRE

    Thiel, Thomas

    2016-01-01

    Im Zentrum der vorliegenden Arbeit steht ein zementgebundener Leichtbeton auf der Basis von aus Altpapier herausgelösten Cellulosefasern; hierfür wird im Folgenden die Bezeichnung CFLC (Cellulose-Fibre Lightweight Concrete) verwendet. Die Intention zur Untersuchung dieses mitunter auch als Papercrete bezeichneten und bislang nur verhältnismäßig wenig erforschten Materials beruht insbesondere darauf, dass von einer Kombination eines leicht verfügbaren pflanzlichen Faserstoffs mit einem mineral...

  12. Ludwig von Bertalanffy Forerunner of Evolutionary Systems Theory

    OpenAIRE

    Wolfgang, Hofkirchner

    2005-01-01

    Ludwig von Bertalanffy is known as founding father of the General System Theory (GST). When Ludwig von Bertalanffy created his GST amidst the last century, he was able to overcome the deep cleft between the controversial theoretical approaches to biology - mechanicism and vitalism. He did so by formulating laws of organisation ruling biota and after generalising them he successfully applied them to different domains such as medicine, psychology, psychotherapy. Methodologically, Bertalanffy re...

  13. Optimized sampling of hydroperoxides and investigations of the water vapour dependence of hydroperoxide formation during ozonolysis of alkenes; Optimierung der Probenahme von Hydroperoxiden und Untersuchungen zur Wasserdampfabhaengigkeit der Bildung von Hydroperoxiden bei der Ozonolyse von Alkenen

    Energy Technology Data Exchange (ETDEWEB)

    Becker, K.H.; Plagens, H.

    1997-06-01

    There are several sampling methods for hydroperoxides none of which is particularly reliable. The authors therefore tested three new methods in order to optimize hydroperoxide sampling and, using the optimized sampling procedure, to investigate the water vapour dependence of hydroperoxide formation during ozonolysis of alkenes. (orig.) [Deutsch] Fuer die Probenahme von Hydroperoxiden existieren verschiedene Verfahren, von denen bisher keines als besonders zuverlaessig angesehen werden konnte. Daher wurden in dieser Arbeit drei Verfahren getestet, um die Probenahme von Hydroperoxiden zu optimieren und mit dem entsprechenden Verfahren die Wasserdampfabhaengigkeit der Bildung von Hydroperoxiden bei der Ozonolyse von Alkenen zu untersuchen. (orig.)

  14. Entwicklung einer kontaktfreien nichtdestruktiven Methode zur Messung von mechanischen und elastischen Eigenschaften von mikromechanischen Mehrschichtsystemen mit akustischen Oberflächenwellen

    OpenAIRE

    Bennis, Abdelali

    2009-01-01

    Mit dieser Arbeit wird ein Beitrag zur Weiterentwicklung der akustischen lasermesstechnischen Verfahren zur Ermittlung von mechanischen und elastischen Eigenschaften von mikromechanischen Mehrschichtsystemen geleistet. Zu diesen Eigenschaften zählen das E-Modul, die Dichte, die Dicke sowie die Poissonzahl. Die meisten akustischen lasermesstechnischen Verfahren basieren auf der optischen Erzeugung von breitbandigen akustischen Wellen in einem Schichtsystem und der Ermittlung der Geschwindig...

  15. Die graphic des ersten buches von Prekmurje

    Directory of Open Access Journals (Sweden)

    Vilko Novak

    1978-12-01

    Full Text Available Das erste Buch, geschrieben im Dialekt von Prekmurje (Übermurgebiet in Slowenien, war die Übersetzung des Kleinen Katechismus von M.Luther, angefertigt von Ferenc Temlin: Mali katechismus … erschienen in Halle, 1715. Über den Übersetzer schrieben bisher ausführlicher M. Rupel und V. Novak, s. Anmerkung 3. Der Verfasser untersucht, wie sich Temlin in seiner Schreibweise an die ungarische Graphik anlehnte, wie vor ihm schon die handschriftlichen Gesangbücher in Prekmurje und die kaj-kroatischen Schriftsteller. Vokalen.- Temlin benutzt konsequent die akutierten a und e fur lange und enge Vokale, indem ihm das nichtakutierte ein nichtakzentuiertes oder kurzakzentuiertes, niedriger aber einen breeiinten, nichtakzentuier­ten oder kurzakzentuierten Vokal bedeutet. Den Reflex von jat  schreibt er konsequent als ei, die dem Dialekt bekannten ö aus dem engen, kurzen postlabialen oder postdentalen e oder ,ü, und ü aus dem ethymologischen u (nur einige Ausnahmen in Lehnwörtern schreibt er mit diesen Buchstaben. (Beispiele für diese und die nächsten Buchstaben und Laute in der Abhandlung. Das lange o, das in seiner Sprache als Diphtong ou  reflektiert, bezeichnet er auch als solches. Konsonanten.- Für einige davon verwendet Temlin ungarische Doppelzeichen, deren Alter und Entwicklung der Verfasser der Abhandlung angibt. Das c bezeichnet T.ständig als cz, das s als /z, nur in einigen Fällen als z. Den letzt angeführten Buchstaben benutzt er konsequent für z.- Komplizierter ist die Bezeichnung der Zischlaute: für č schreibt T. sehr haufig cf, aber noch häufiger mit cs, sehr selten dagegen ch - Dies scheint aus kirchlichen Ausdrücken, aus kaj-kroatischen Büchern entnommen bzw. Durch die Kirche erlernt.- Das š bezeichnet T. mit doch nicht selten auch mit Dieselben zwei Buchstaben dienen ihm auch für die Bezeichnung des Lautes ž. Bei den Labiallauten ist zu bemerken, dass T. für die Präposition vu manch­ mal schreibt, sonst

  16. Politische Bildung im Kontext von Regierung, Unterricht und Zucht

    Directory of Open Access Journals (Sweden)

    Thomas Rucker

    2014-02-01

    Full Text Available Johann Friedrich Herbart (1776-1841 gilt als der Begründer der wissenschaftlichen Pädagogik. In diesem Beitrag wird zu zeigen versucht, dass Herbart die Unterstützung politischer Bildung als eine Aufgabe von Regierung, Unterricht und Zucht bestimmt und in seinem Werk wichtige „Bausteine“ für eine Theorie der politischen Bildung unter den Bedingungen von Erziehung vorlegt hat. Nach Herbart ist das politische Selbst- und Weltverhältnis auf Sachverhalte bezogen, die nicht nur die Lebensführung einzelner Menschen, sondern die Lebensführung einer Mehrzahl von Menschen betreffen. Nicht das Zusammenleben von Menschen generell ist jedoch Orientierungsgesichtspunkt des politischen Selbst- und Weltverhältnisses, sondern nur das problematisch gewordene Zusammenleben. Politik ergibt sich nach Herbart aus einem Konflikt hinsichtlich der Frage, wie das Zusammenleben von Menschen geregelt sein sollte. Während die Regierung lediglich mittelbar einen Beitrag zur politischen Bildung leistet, indem sie die Voraussetzungen für Unterricht und Zucht bereitstellt, fungieren die beiden zuletzt genannten Formen von Erziehung als die eigentlichen Medien, in denen die politische Bildung im Sinne Herbarts ihren Ort hat.

  17. Design of recuperators; Nachrechnung von Rekuperatoren. Moeglichkeiten zur Loesung der inverse Aufgabe bei waermetechnischen Berechnungen von Rekuperatoren mit Metallrohren

    Energy Technology Data Exchange (ETDEWEB)

    Stanev, R. [Univ. fuer Chemische Technologie und Metallurgie, Sofia (Bulgaria). Lehrstuhl fuer Physikalische Metalurgie und Waermeanlagen

    2004-02-01

    Possibilities for solution of the inverse task by heat-technical calculation of recuperators with metal pipes. The utilization of the waste heat in recuperators permits a decrease the fuel consumption of industrial and especially of metallurgical furnaces up to 30%. In the paper is represented a possibility for calculation of recuperators, which is useable not only for this application, than also for the design of air-coolers and other heat-exchangers. (orig.) [German] Die Abgaswaermenutzung mittels Rekuperator erlaubt eine Senkung des Brennstoffverbrauchs von Industrieoefen und insbesondere von den metallurgischen Oefen um bis zu 30%. Im Beitrag wird eine Moeglichkeit der Berechnung von Rekuperatoren vorgestellt, die nicht nur fuer diese Anwendung, sondern auch fuer die Auslegung von Luftkuehlern und anderen Waermeuebertragern verwendet werden kann. (orig.)

  18. Bitcoins. Eine Analyse von Kryptowaehrungen und deren Anwendung von kontroversiellen Angeboten im Darknet bis hin zu traditionellem Onlinehandel.

    OpenAIRE

    Linzner, Manfred

    2016-01-01

    von Manfred Linzner Arbeit an der Bibliothek noch nicht eingelangt - Daten nicht geprueft - Link noch nicht aktiv Abweichender Titel nach Übersetzung der Verfasserin/des Verfassers Technische Universität Wien, Univ., Diplomarbeit, 2016

  19. Prophylaxis escalation in severe von Willebrand disease: A prospective study from the von Willebrand Disease Prophylaxis Network

    NARCIS (Netherlands)

    T.C. Abshire (Thomas Calvin); J. Cox-Gill; C.L. Kempton; F.W.G. Leebeek (Frank); M. Carcao (M.); P. Kouides (P.); S. Donfield (S.); E. Berntorp

    2015-01-01

    textabstractBackground: Treatment of mucosal bleeding (epistaxis, gastrointestinal bleeding, and menorrhagia) and joint bleeding remains problematic in clinically severe von Willebrand disease (VWD). Patients are often unresponsive to treatment (e.g. desmopressin or antifibrinolytic therapy) and may

  20. Electronic Resource Management System. Vernetzung von Lizenzinformationen

    Directory of Open Access Journals (Sweden)

    Michaela Selbach

    2014-12-01

    Full Text Available In den letzten zehn Jahren spielen elektronische Ressourcen im Bereich der Erwerbung eine zunehmend wichtige Rolle: Eindeutig lässt sich hier ein Wandel in den Bibliotheken (fort vom reinen Printbestand zu immer größeren E-Only-Beständen feststellen. Die stetig wachsende Menge an E-Ressourcen und deren Heterogenität stellt Bibliotheken vor die Herausforderung, die E-Ressourcen effizient zu verwalten. Nicht nur Bibliotheken, sondern auch verhandlungsführende Institutionen von Konsortial- und Allianzlizenzen benötigen ein geeignetes Instrument zur Verwaltung von Lizenzinformationen, welches den komplexen Anforderungen moderner E-Ressourcen gerecht wird. Die Deutsche Forschungsgemeinschaft (DFG unterstützt ein Projekt des Hochschulbibliothekszentrums des Landes Nordrhein-Westfalen (hbz, der Universitätsbibliothek Freiburg, der Verbundzentrale des Gemeinsamen Bibliotheksverbundes (GBV und der Universitätsbibliothek Frankfurt, in dem ein bundesweit verfügbares Electronic Ressource Managementsystem (ERMS aufgebaut werden soll. Ein solches ERMS soll auf Basis einer zentralen Knowledge Base eine einheitliche Nutzung von Daten zur Lizenzverwaltung elektronischer Ressourcen auf lokaler, regionaler und nationaler Ebene ermöglichen. Statistische Auswertungen, Rechteverwaltung für alle angeschlossenen Bibliotheken, kooperative Datenpflege sowie ein über standardisierte Schnittstellen geführter Datenaustausch stehen bei der Erarbeitung der Anforderungen ebenso im Fokus wie die Entwicklung eines Daten- und Funktionsmodells. In the last few years the importance of electronic resources in library acquisitions has increased significantly. There has been a shift from mere print holdings to both e- and print combinations and even e-only subscriptions. This shift poses a double challenge for libraries: On the one hand they have to provide their e-resource collections to library users in an appealing way, on the other hand they have to manage these

  1. Jade aus Amerika und weitere Grünsteinobjekte von Alexander von Humboldt aus dem Berliner Mineralienkabinett

    OpenAIRE

    Renate Nöller

    2009-01-01

    Alexander von Humboldt schickte aus Amerika Mineralproben, die nicht nur von naturwissenschaftlichem oder wirtschaftlichem Interesse waren. Vor allem grünes Steinmaterial, sogenannte Jade, war in Mesoamerika kulturell sehr bedeutsam und weit verbreitet, so daß sich aus diesem Rohstoff in der Sammlung auch bearbeitete Stücke vorfinden. Sie erlangten in Europa unterschiedliche Aufmerksamkeit. Die Jadeaxt und die Sonnenscheibe - beide im zweiten Weltkrieg verloren gegangen, hatten als “Humboldt-...

  2. Entwicklung von Dünnschicht-Reaktionsröhrchen zur Bestimmung von Schwefelwasserstoff, Chlor und Tetrachlorethen in Luft

    OpenAIRE

    Schwierz, Torge

    2000-01-01

    Dünnschicht-Reaktionsröhrchen zeichnen sich gegenüber konventionellen Prüfröhrchen durch höhere analytische Leistungen (Nachweisvermögen, Reproduzierbarkeit, Empfindlichkeit, objektive Auswertung) aus, ohne die Vorteile der einfachen praktischen Handhabung bei gasspurenanalytischen Messungen aufzugeben. In der vorliegenden Arbeit wird die Entwicklung von Dünnschicht-Reaktionsröhrchen für die Analyten Schwefelwasserstoff, Chlor und Tetrachlorethen beschrieben. Zum Nachweis von Schwefelwasserst...

  3. Die Rolle von Aldosteron im Knochenstoffwechsel

    Directory of Open Access Journals (Sweden)

    Tomaschitz A

    2012-01-01

    Full Text Available Das Steroidhormon Aldosteron wird in der Zona glomerulosa (ZG der Nebennierenrinde produziert. Kalzium spielt als gemeinsamer „Second Messenger“ eine zentrale Rolle in der durch Angiotensin II, ACTH und Kalium regulierten Aldosteronsynthese. Zahlreiche Studien der vergangenen Jahre dokumentierten die bedeutende Rolle des Aldosterons in der Pathogenese kardiovaskulärer Erkrankungen. Effekte von Aldosteron auf den Knochenstoffwechsel wurden bisher kaum untersucht. In humanen fetalen und adulten Knochenzellen wurde jedoch eine ausgeprägte Expression des Mineralokortikoidrezeptors (MR detektiert. In experimentellen Tierstudien wurden sowohl eine spezifische Aldosteron-MR-Interaktion im Knochengewebe als auch die osteoprotektive Wirkung der MR-Blockade mit Spironolakton beobachtet. Aldosteron kann durch die Hemmung der alkalischen Phosphatase indirekt eine gesteigerte Osteoblastenproliferation induzieren. Die wechselseitige Beeinflussung von Aldosteron und Parathormon (PTH könnte eine bedeutende Rolle in der Pathophysiologie kardiovaskulärer Erkrankungen und des Knochenstoffwechsels spielen. PTH kann sowohl über die Aktivierung spannungsabhängiger Kalziumkanäle als auch durch Bindung an den PTH/PTH-rP-Rezeptor der Zona-glomerulosa- Zellen eine Stimulation der Aldosteronsynthese induzieren. Dies bestätigt sich mit einem signifikanten Rückgang der Plasmaaldosteronkonzentration nach einer Parathyreoidektomie bei Patienten mit einem primären Hyperparathyreoidismus. In Tiermodellen der Herzinsuffizienz führt der relative Aldosteronüberschuss über eine verstärkte renale Kalziumexkretion zu einem sekundären Hyperparathyreoidismus, der durch die gesteigerte Kalziummobilisation aus dem Knochengewebe zu einem erhöhten Frakturrisiko in dieser Patientengruppe beiträgt. Der im Rahmen des primären Hyperaldosteronismus beobachtete sekundäre Hyperparathyreoidismus kann durch eine Hemmung der Aldosteronwirkung/Aldosteronsynthese supprimiert

  4. Von Roll RCP method - first experiences; Von Roll RCP - Verfahren. Erste Erfahrungen

    Energy Technology Data Exchange (ETDEWEB)

    Capitaine, P.; Engweiler, J. [Roll Umwelttechnik AG, Zuerich (Switzerland)

    1998-09-01

    The RCP method was designed as a residue-optimised alternative to the thermally optimised grate firing of residual wastes. Its technical realisation and development to market maturity took no more than 5 years. In the first process stage the waste is converted to high-carbon pyrolysis charcoal and high-rank gas in the absence of oxygen. In the second stage these substances are oxidised by addition of oxygen. The resulting temperature causes the non-combustible constituents of the slag to melt. In a third, optional, stage this molten slag can be liberated of (heavy) metals to such an extent that it can subsequently be used directly as additive for grinding. Further exhaust gas treatment is facilitated by the use of a circulatory fluidised-bed secondary combustion chamber. Despite the reduced flue gas volume and resultant higher pollutant concentrations in the crude gas, overall emissions are lower than in conventional plants. [Deutsch] Das reststoffoptimierte RCP Verfahren ist als Alternative zur thermisch optimierten Rostverbrennung von Restabfaellen konzipiert. In nur fuenf Jahren wurde das Verfahren technisch umgesetzt und zur Marktreife entwickelt. In einer ersten Stufe des Verfahrens wird der Abfall unter Luftabschluss in einen kohlenstoffreichen Pyrolysekoks und eine heizwertreiches Gas umgesetzt. Im zweiten Schritt werden diese Stoffe unter Zugabe von Sauerstoff oxidiert. Dabei treten Temperaturen auf, bei denen die nichtbrennbaren Bestandteile der Schlacke schmelzen. Optional wird diese Schmelzschlacke in einem dritten Schritt derart von (Schwer-) Metallen befreit, dass sie anschliessend direkt als Zement-Zumahlstoff eingesetzt werden kann. Die Nutzung der zirkulierenden Wirbelschicht - Nachbrennkammer zur Abgasbehandlung vereinfacht die weitergehende Abgasbehandlung. Trotz verringertem Rauchgasvolumen und damit hoeheren Schadstoffkonzentrationen im Rohgas werden die Gesamtemissionen gegenueber konventionellen Anlagen verringert. (orig./SR)

  5. GFRP life in wind rotor blades; Lebensdauer von GFK im Holmgurt und im Schubsteg von Rotorblaettern

    Energy Technology Data Exchange (ETDEWEB)

    Kensche, C.W. [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Stuttgart (Germany). Inst. fuer Bauweisen- und Konstruktionsforschung

    1999-07-01

    Lives of GFRP rotor blade components were calculated on the basis of Woehler curves and the wind power specific standard WISPERX using the linear Palmgren-Miner rule. The Calculations were based on experiments with belts made of the L20/SL epoxy resin system at pressure ratios R=0.1, and -1 and with torsionally stressed GFRP tubes of linen tissue with the epoxy resing GE162/C260 at R=0.1 and -1. The results were incorporated into Haigh diagrams, from which the damage from the collective load was calculated by linear interpolation of the averaged stresses and amplitudes resp. the lines of constant life. The life curves calculated for different maximum stress horizons are in good agreement with experimental collective loads. A comparison of life curves showed that the linen tissue material was more fatigue-sensitive than the belt material. [German] Fuer GFK-Gurte und Schubstege von Rotorblaettern wurden Lebensdauerberechnungen auf der Basis von Woehlerkurven und dem windenergiespezifischen Standard WISPERX unter Anwendung der linearen Palmgren-Miner Regel durchgefuehrt. Bei der Betrachtung der Gurte wurde auf Versuche an UD-Proben mit dem Epoxidharzsystem L20/SL zurueckgegriffen, die bei Spannungsverhaeltnissen von R=0.1, -1 und 10 durchgefuehrt worden waren. Grundlage fuer die Lebensdauerbestimmung der Schubstege waren Ermuedungsversuche an torsionsbelasteten GFK-Rohren aus Leinengewebe mit dem Epoxidharz GE162/C260 bei R=0.1 und -1. In den daraus konstruierten Haighdiagrammen wurden die Schaedigungen durch das Lastkollektiv mittels linearer Interpolation der Mittelspannungen und Amplituden bzw. der Linien konstanter Lebensdauer ermittelt. Die Lebensdauerkurven, die fuer verschiedene Maximalspannungshorizonte ermittelt wurden, stimmen gut mit experimentellen Lastkollektivergebnissen ueberein. Beim Vergleich der Lebensdauerkurven zeigt sich, dass ein Leinengewebesteg erheblich ermuedungsgefaehrdeter ist als ein Gurt. (orig.)

  6. Entstehungsbedingungen von Übergängen von der Schule in den Beruf aus qualitativer und quantitativer Perspektive

    Directory of Open Access Journals (Sweden)

    Nora Gaupp

    2013-03-01

    Full Text Available Methodenintegration wird in den Sozialwissenschaften mit dem Argument sich ergänzender Erkenntnismöglichkeiten häufig gefordert. Die vorliegende Analyse zu Übergangswegen von der Schule in Ausbildung und Arbeit von Jugendlichen mit Hauptschulbildung beruht auf Daten einer quantitativen Panelstudie und einer qualitativen Ergänzungsstudie. Aus quantitativer und qualitativer Perspektive wird jeweils ein Einzelfall betrachtet sowie im Rahmen einer Modellbildung eine Verallgemeinerung auf Aggregatebene vorgenommen. Über ein logistisches Regressionsmodell wird die Bedeutung von zentralen individuellen, sozialen und strukturellen Merkmalen wie Schulleistungen, beruflichen Plänen, individuellen Problembelastungen, Migrationshintergrund und Arbeitslosigkeit der Eltern sowie regionaler Arbeitsmarktsituation für den Verlauf von Übergangswegen (Direkteinstieg in Ausbildung, Umweg in Ausbildung über schulische oder berufsvorbereitende Zwischenschritte, fortgesetzter mehrjähriger Schulbesuch und prekäre Wege in Ausbildungslosigkeit untersucht. Über das qualitative Paradigma konnten vier für den Verlauf von Übergängen zentrale Dimensionen identifiziert werden: Agency, Motivation, kritische biografische Ereignisse und soziale Interaktionen. Der Schritt der Modellbildung integriert die vier Erfahrungsebenen und zeigt ihre Bedeutung für Übergänge von der Schule in den Beruf. Die Diskussion fragt nach Möglichkeiten und Grenzen der Erkenntnisentwicklung der beiden Forschungszugänge. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1302126

  7. Einfluss von verschiedenen Erodierstrukturen auf den Reibwert von Kunststoff-Kunststoff Paarungen

    OpenAIRE

    Bergmann, André

    2016-01-01

    Im Beitrag werden bei verschiedenen Lastkollektiven und zwei Reibgeschwindigkeiten die Erodierstrukturen K27, K36, K42 und die Ätzstruktur K36 mit glatten Probekörpern hinsichtlich des Reibwertes und des Verschleißverhaltens untersucht. Als strukturierte Probekörper kommen die Kunststoffe POM und PA und als Gegenkörper zwei verschiedene PE-UHMW´s zum Einsatz. Die Ergebnisse zeigen eine deutliche Abhängigkeit des Reibwertes von der Oberflächenstruktur der Probekörper, jedoch ist die Senkun...

  8. "Die Toten reiten schnelle." Literarische Zitate in Briefen von und an Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Ingo Schwarz

    2007-04-01

    Full Text Available Article in GermanAbstract in English and GermanAlexander von Humboldt and his correspondents liked to enrich or embellish their letters with quotations from classic works of ancient literature as well as from recent poems, plays, or novels. This paper tries to show that references to literature were very often used in order to express thoughts and feelings more clearly not so much for impressing the recipients of letters with high education. In educated circles a good knowledge of ancient and modern works of literature was a standard requirement, which often allowed the letter writers to use quotations in a playful manner.

  9. Entwurf und Simulation von Makromodellen zur transienten Simulation von thermo-elektrischen Kopplungen in einem Netzwerksimulator

    OpenAIRE

    Schacht, Ralph Karl Benjamin

    2002-01-01

    In der vorliegenden Arbeit wird eine Methode vorgestellt, welche die Beschreibung und Si-mulation von thermo-elektrischen Kopplungen während des Design-Prozesses mittels Mak-romodellierung unterstützt. Das Makromodell ist für den Einsatz in dem Schaltungssimulator PSpice zugeschnitten. Es ermöglicht die rechenzeiteffiziente transiente Simulation zwischen thermo-elektrisch gekoppelten Komponenten eines komplexen Mikrosystems. Im Rahmen dieser Arbeit wurde zunächst eine für die Problemstellung ...

  10. Influência do cálcio na calda de pulverização sobre a eficácia do carfentrazone-ethyl no controle de Euphorbia heterophylla

    OpenAIRE

    Carvalho,F.T.; Caetano,L.; Peruchi,M.; Palazzo,R.R.B.

    2001-01-01

    Alguns herbicidas podem ter sua eficácia de controle das plantas daninhas diminuída quando o cálcio encontra-se presente na calda de pulverização. Sendo assim, o presente trabalho foi desenvolvido com o objetivo de estudar a influência do cálcio na eficácia do herbicida carfentrazone-ethyl aplicado em pós-emergência sobre plantas adultas de Euphorbia heterophylla. Foram conduzidos dois experimentos com as concentrações de cálcio variando de 30 a 240 ppm e de 0 a 1.000 ppm respectivamente em c...

  11. Zur Struktur und Funktion von Synonymen

    Directory of Open Access Journals (Sweden)

    Marina Zorman

    1998-12-01

    Full Text Available Der Artikel behandelt die Synonyme im Licht der funktionell-strukturellen Sprachtheorie Coserius. 1 Die Wahl der theoretischen Grundsätze wurde durch die Festellung diktiert, daß die bisherigen Erkenntnisse über die Synonymie widersprüchlich sind und daß auch schon über alle Feststellungen berechtigte Einsprüche erhoben wurden. Deshalb wird in dieser Arbeit auf der genannten theoretischen Grundlage, die verschiedene Gesichtspunkte des Problems verbindet, anstatt sie zu trennen (s. Punkt 2, ein Modell für die Analyse von Synonymen vorgestellt (3, das die klassischen Schwächen der Semantikforschung (zu geringe Menge tatsächlicher Daten, Subjektivität und Introspektion durch eine empirische Untersuchung in einem Textkorpus zu ersetzen versucht. In die Analyse sind drei Inhaltsebenen einbezogen (Bezeichnung, Bedeutung und Sinn und ihnen sind jeweils entsprechende Untersuchungsmethoden zugeordnet. Im Sinne des Modells wurden in der Arbeit Zorman 1997 zwei slowenische Synonympaare (kuverta - ovojnica und borba - boj analysiert, die als Beispiele reiner (und totaler Synonymie gelten können. Die Analyse wird aus Platzgründen an dieser Stelle nicht detailliert dargestellt,2 veranschaulicht werden nur ihre Tragweite und die Ergebnisse (4. Im letzten Teil (5 werden die Leistungen der vorgeschlagenen Methode bewertet und einige Annahmen dargestellt, die der weiteren Erforschung der Synonyme dienen könnten. Die objektive Behandlung der Synonymie unter unterschiedlichen Gesichtspunkten scheint einige Dogmen über Synonyme in Frage zu  stellen.

  12. Assessment of Euphorbia hirta L. Leaf, Flower, Stem and Root Extracts for Their Antibacterial and Antifungal Activity and Brine Shrimp Lethality

    Directory of Open Access Journals (Sweden)

    Santhanam Amutha

    2010-08-01

    Full Text Available The antimicrobial activities of the methanolic extracts of Euphorbia hirta L leaves, flowers, stems and roots were evaluated against some medically important bacteria and yeast using the agar disc diffusion method. Four Gram positive (Staphylococcus aureus, Micrococcus sp., Bacillus subtilis and Bacillus thuringensis, four Gram negative (Escherichia coli, Klebsiella pneumonia, Salmonella typhi and P. mirabilis and one yeast (Candida albicans species were screened. Inhibition zones ranged between 16–29 mm. Leaves extract inhibited the growth of all tested microorganisms with large zones of inhibition, followed by that of flowers, which also inhibited all the bacteria except C. albicans. The most susceptible microbes to all extracts were S. aureus and Micrococcus sp. Root extract displayed larger inhibition zones against Gram positive bacteria than Gram negative bacteria and had larger inhibition zones compared to stem extract. The lowest MIC values were obtained with E. coli and C. albicans (3.12 mg/mL, followed by S. aureus (12.50 mg/mL and P. mirabilis (50.00 mg/mL. All the other bacteria had MIC values of 100.00 mg/mL. Scanning Electron Microscopic (SEM studies revealed that the cells exposed to leaf extract displayed a rough surface with multiple blends and invaginations which increased with increasing time of treatment, and cells exposed to leaf extract for 36 h showed the most damage, with abundant surface cracks which may be related to final cell collapse and lossThe antimicrobial activities of the methanolic extracts of Euphorbia hirta L leaves, flowers, stems and roots were evaluated against some medically important bacteria and yeast using the agar disc diffusion method. Four Gram positive (Staphylococcus aureus, Micrococcus sp., Bacillus subtilis and Bacillus thuringensis, four Gram negative (Escherichia coli, Klebsiella pneumonia, Salmonella typhi and P. mirabilis and one yeast (Candida albicans species were screened. Inhibition

  13. Polymorphism in the promoter region of von Willebrand factor gene and von Willebrand disease type 1

    Directory of Open Access Journals (Sweden)

    Daniel Simon

    2003-12-01

    Full Text Available The -1185A/G polymorphism in the 5'-regulatory region of the von Willebrand factor (VWF gene was associated with VWF plasma levels in a normal population. This study was undertaken to evaluate whether there is a relationship between this polymorphism and type 1 von Willebrand disease (VWD, a disorder characterized by a quantitative deficiency of VWF. The association between this polymorphism and plasma VWF levels in normal Brazilian individuals was also analyzed. Control subjects (n = 460 and type 1 VWD patients (n = 41 were studied. Polymerase chain reaction (PCR amplification of the 864-bp VWF promoter region followed by AccII restriction-digestion was used to identify the -1185A/G genotypes. The -1185G allele frequency was 57% in normal individuals and 63% in type 1 VWD patients, this difference was not significant (p = 0.29. No significant association was observed between -1185A/G genotypes and VWF plasma levels in normal individuals, although VWF levels were in the same direction as those reported by another study, with subjects carrying the G allele having the lower levels. These results suggest that -1185A/G polymorphism is not associated with the partial deficiency of VWF in type 1 VWD patients.

  14. Agrobacterium tumefaciens-mediated transformation of poinsettia, Euphorbia pulcherrima, with virus-derived hairpin RNA constructs confers resistance to Poinsettia mosaic virus.

    Science.gov (United States)

    Clarke, Jihong Liu; Spetz, Carl; Haugslien, Sissel; Xing, Shaochen; Dees, Merete W; Moe, Roar; Blystad, Dag-Ragnar

    2008-06-01

    Agrobacterium-mediated transformation for poinsettia (Euphorbia pulcherrima Willd. Ex Klotzsch) is reported here for the first time. Internode stem explants of poinsettia cv. Millenium were transformed by Agrobacterium tumefaciens, strain LBA 4404, harbouring virus-derived hairpin (hp) RNA gene constructs to induce RNA silencing-mediated resistance to Poinsettia mosaic virus (PnMV). Prior to transformation, an efficient somatic embryogenesis system was developed for poinsettia cv. Millenium in which about 75% of the explants produced somatic embryos. In 5 experiments utilizing 868 explants, 18 independent transgenic lines were generated. An average transformation frequency of 2.1% (range 1.2-3.5%) was revealed. Stable integration of transgenes into the poinsettia nuclear genome was confirmed by PCR and Southern blot analysis. Both single- and multiple-copy transgene integration into the poinsettia genome were found among transformants. Transgenic poinsettia plants showing resistance to mechanical inoculation of PnMV were detected by double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA). Northern blot analysis of low molecular weight RNA revealed that transgene-derived small interfering (si) RNA molecules were detected among the poinsettia transformants prior to inoculation. The Agrobacterium-mediated transformation methodology developed in the current study should facilitate improvement of this ornamental plant with enhanced disease resistance, quality improvement and desirable colour alteration. Because poinsettia is a non-food, non-feed plant and is not propagated through sexual reproduction, this is likely to be more acceptable even in areas where genetically modified crops are currently not cultivated.

  15. Polyphenolic Extract of Euphorbia supina Attenuates Manganese-Induced Neurotoxicity by Enhancing Antioxidant Activity through Regulation of ER Stress and ER Stress-Mediated Apoptosis

    Directory of Open Access Journals (Sweden)

    Entaz Bahar

    2017-01-01

    Full Text Available Manganese (Mn is an important trace element present in human body, which acts as an enzyme co-factor or activator in various metabolic reactions. While essential in trace amounts, excess levels of Mn in human brain can produce neurotoxicity, including idiopathic Parkinson’s disease (PD-like extrapyramidal manganism symptoms. This study aimed to investigate the protective role of polyphenolic extract of Euphorbia supina (PPEES on Mn-induced neurotoxicity and the underlying mechanism in human neuroblastoma SKNMC cells and Sprague-Dawley (SD male rat brain. PPEES possessed significant amount of total phenolic and flavonoid contents. PPEES also showed significant antioxidant activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH radical scavenging and reducing power capacity (RPC assays. Our results showed that Mn treatment significantly reduced cell viability and increased lactate dehydrogenase (LDH level, which was attenuated by PPEES pretreatment at 100 and 200 µg/mL. Additionally, PPEES pretreatment markedly attenuated Mn-induced antioxidant status alteration by resolving the ROS, MDA and GSH levels and SOD and CAT activities. PPEES pretreatment also significantly attenuated Mn-induced mitochondrial membrane potential (ΔΨm and apoptosis. Meanwhile, PPEES pretreatment significantly reversed the Mn-induced alteration in the GRP78, GADD34, XBP-1, CHOP, Bcl-2, Bax and caspase-3 activities. Furthermore, administration of PPEES (100 and 200 mg/kg to Mn exposed rats showed improvement of histopathological alteration in comparison to Mn-treated rats. Moreover, administration of PPEES to Mn exposed rats showed significant reduction of 8-OHdG and Bax immunoreactivity. The results suggest that PPEES treatment reduces Mn-induced oxidative stress and neuronal cell loss in SKNMC cells and in the rat brain. Therefore, PPEES may be considered as potential treat-ment in Mn-intoxicated patients.

  16. Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR.

    Directory of Open Access Journals (Sweden)

    Celina M Abreu

    Full Text Available HIV infection is not cleared by antiretroviral drugs due to the presence of latently infected cells that are not eliminated with current therapies and persist in the blood and organs of infected patients. New compounds to activate these latent reservoirs have been evaluated so that, along with HAART, they can be used to activate latent virus and eliminate the latently infected cells resulting in eradication of viral infection. Here we describe three novel diterpenes isolated from the sap of Euphorbia tirucalli, a tropical shrub. These molecules, identified as ingenols, were modified at carbon 3 and termed ingenol synthetic derivatives (ISD. They activated the HIV-LTR in reporter cell lines and human PBMCs with latent virus in concentrations as low as 10 nM. ISDs were also able to inhibit the replication of HIV-1 subtype B and C in MT-4 cells and human PBMCs at concentrations of EC50 0.02 and 0.09 µM respectively, which are comparable to the EC50 of some antiretroviral currently used in AIDS treatment. Control of viral replication may be caused by downregulation of surface CD4, CCR5 and CXCR4 observed after ISD treatment in vitro. These compounds appear to be less cytotoxic than other diterpenes such as PMA and prostratin, with effective dose versus toxic dose TI>400. Although the mechanisms of action of the three ISDs are primarily attributed to the PKC pathway, downregulation of surface receptors and stimulation of the viral LTR might be differentially modulated by different PKC isoforms.

  17. Primary and secondary abscission in Pisum sativum and Euphorbia pulcherrima –how do they compare and how do they differ?

    Directory of Open Access Journals (Sweden)

    Anne Kathrine (Trine eHvoslef-Eide

    2016-01-01

    Full Text Available ABSTRACTAbscission is a highly regulated and coordinated developmental process in plants. It is important to understand the processes leading up to the event, in order to better control abscission in crop plants. This has the potential to reduce yield losses in the field and increase the ornamental value of flowers and potted plants. A reliable method of abscission induction in poinsettia (Euphorbia pulcherrima flowers has been established to study the process in a comprehensive manner. By correctly decapitating buds of the third order, abscission can be induced in one week. AFLP differential display (DD was used to search for genes regulating abscission. Through validation using qRT-PCR, more information of the genes involved during induced secondary abscission have been obtained. A study using two mutants of pea (Pisum sativum in the def (Developmental funiculus gene have been performed and compared these with wild type peas (tall and dwarf in both cases. The def mutant results in a deformed, abscission-less zone instead of normal primary abscission at the funiculus. RNA in situ hybridization studies using gene sequences from the poinsettia differential display, resulted in six genes differentially expressed for abscission specific genes in both poinsettia and pea. Two of these genes are associated with gene up- or down-regulation during the first two days after decapitation in poinsettia. Present and previous results in poinsettia (biochemically and gene expressions, enables a more detailed division of the secondary abscission phases in poinsettia than what has previously been described from primary abscission in Arabidopsis.This study compares the inducible secondary abscission in poinsettia and the non-abscising mutants/wild types in pea demonstrating primary abscission zones. The results may have wide implications on the understanding of abscission, since pea and poinsettia have been separated for 94-98 million years in evolution, hence

  18. Attenuation of nociceptive pain and inflammatory disorders by total steroid and terpenoid fraction of Euphorbia tirucalli Linn root in experimental in vitro and in vivo model.

    Science.gov (United States)

    Palit, Partha; Mukherjee, Dhrubojyoti; Mahanta, Poulami; Shadab, Md; Ali, Nahid; Roychoudhury, Shubhadeep; Asad, Md; Mandal, Subhash C

    2017-10-23

    The plant Euphorbia tirucalli Linn has been successfully used as a tribal folk medicine in India and Africa for the management of acute inflammatory, arthritic, nociceptive pain and asthmatic symptoms. The present study was conducted to assess the anti-inflammatory, analgesic, anti-asthmatic and anti-arthritic role of the total steroid and terpenoid rich fractions of the hydro-alcoholic extract of E. tirucalli root (STF-HAETR). STF-HAETR fraction demonstrated 71.25 ± 2.5 and 74.25 ± 5.1% protection against acetic acid-induced pain and central neuropathic pain at 75 and 100 mg/kg doses, respectively. It showed 96.97% protection against acute inflammation at 100 mg/kg with 1.6-fold better activity than the standard drug. The fraction exhibited such efficacy via inhibition of proinflammatory cytokines TNF-α, IFN-γ, by 61.12 and 65.18%, respectively, at 100 μg/mL. Inhibition of cyclooxygenase and Nitric oxide synthase in a dose-dependent manner affirms its analgesic and anti-inflammatory activity. The spectrophotometric analysis reveals that STF-HAETR induces ameliorative effect against heat-induced denaturation of Bovine serum albumin (BSA) and exhibits significant anti-proteinase activity. The plant fraction also demonstrated anti-asthmatic activity by displaying 62.45% protection against histamine induced bronchoconstriction or dyspnoea. Our findings suggest that STF-HAETR could be an effective safe therapeutic agent to treat nociceptive pain, acute inflammation, asthma, and arthritis which may authenticate its traditional use.

  19. Entwicklungsperspektiven von Social Software und dem Web 2.0

    Science.gov (United States)

    Raabe, Alexander

    Der Artikel beschäftigt sich zunächst mit dem derzeitigen und zukünftigen Einsatz von Social Software in Unternehmen. Nach dem großen Erfolg von Social Software im Web beginnen viele Unternehmen eigene Social Software-Initiativen zu entwickeln. Der Artikel zeigt die derzeit wahrgenommenen Einsatzmöglichkeiten von Social Software im Unternehmen auf, erörtert Erfolgsfaktoren für die Einführung und präsentiert mögliche Wege für die Zukunft. Nach der Diskussion des Spezialfalles Social Software in Unternehmen werden anschließend die globalen Trends und Zukunftsperspektiven des Web 2.0 in ihren technischen, wirtschaftlichen und sozialen Dimensionen dargestellt. Wie aus den besprochenen Haupttrends hervorgeht, wird die Masse an digital im Web verfügbaren Informationen stetig weiterwachsen. So stellt sich die Frage, wie es in Zukunft möglich sein wird, die Qualität der Informationssuche und der Wissensgenerierung zu verbessern. Mit dem Einsatz von semantischen Technologien im Web wird hier eine revolutionäre Möglichkeit geboten, Informationen zu filtern und intelligente, gewissermaßen verstehende" Anwendungen zu entwerfen. Auf dem Weg zu einem intelligenten Web werden sich das Semantic Web und Social Software annähern: Anwendungen wie Semantic Wikis, Semantic Weblogs, lightweight Semantic Web-Sprachen wie Microformats oder auch kommerzielle Angebote wie Freebase von Metaweb werden die ersten Vorzeichen einer dritten Generation des Webs sein.

  20. Acquired von Willebrand syndrome: A rare disorder of heterogeneous etiology

    Directory of Open Access Journals (Sweden)

    P Kasatkar

    2013-01-01

    Full Text Available Context: Acquired von Willebrand syndrome (AVWS is a rare bleeding disorder that mimics the inherited form of von Willebrand disease (VWD in terms of laboratory findings and clinical presentation. Aims: To study the etiology of acquired VWD. Settings and Design: The patients referred from various hospitals in and out of Mumbai were included in the study. Materials and Methods: Six patients with AVWS diagnosed at this center over the last 10 years were analyzed against 171 patients with inherited VWD. The differential diagnosis of AVWS was made based on reduced levels of von Willebrand antigen and von Willebrand ristocetin cofactor, decrease in ristocetin induced platelet aggregation, absence of correction in mixing studies with no prior history of bleeding problems and a negative family history for bleeding disorders. Results: In three patients, the disease was associated with systematic lupus erythematosus, out of which one was also associated with Kikuchi lymphadenitis and second with autoimmune hemolytic anemia. Fourth case was associated with hypothyroidism and fifth was a case of dermatitis and vitiligo. The last patient was a case of hemophilia A with Burkitts lymphoma, who developed autoantibodies to von Willebrand factor. Except two patients, all other patients responded to immune suppressive therapy with corticosteroids, while the patient with hypothyroidism responded to oral thyroxine. Conclusion: AVWS is a rare condition and may often be missed or diagnosed as inherited disease associated with heterogeneous disease conditions.

  1. Biographical sketch: Georg Hermann von Meyer (1815-1892).

    Science.gov (United States)

    Skedros, John G; Brand, Richard A

    2011-11-01

    This biographical sketch on Georg Hermann von Meyer highlights the interactions in the 1860s that von Meyer, a famous anatomist, had with Karl Culmann, a famous structural engineer and mathematician. The published papers from this interaction caught the attention of Julius Wolff and stimulated his development of the trajectorial hypothesis of bone adaptation--now called "Wolff's Law." The corresponding translations are provided: (1) von Meyer's 1867 paper that highlights the regularity of arched trabecular patterns in various human bones, and his discussions with Culmann about their possible mechanical relevance; and (2) Wolff's 1869 paper that first mentions the correspondence of stress trajectories in a solid, crane-like structure to the arched trabecular patterns in the proximal human femur. This biographical sketch on Georg Hermann von Meyer corresponds to the historic texts, The Classic: The Architecture of the Trabecular bone (by von Meyer), and The Classic: On the Significance of the Architecture of the Spongy Substance for the Question of Bone Growth. A preliminary publication (by Wolff) available at DOIs 10.1007/s11999-011-2041-5 , 10.1007/s11999-011-2042-4 .

  2. Choroba von Willebranda – najczęstsza osoczowa skaza krwotoczna

    Directory of Open Access Journals (Sweden)

    Bożena Sokołowska

    2010-08-01

    Full Text Available Von Willebrand disease is the most common hereditary haemorrhagic disorder. A majority of patients (70%have classic mild or moderate (type I von Willebrand disease, and women are mostly affected. Clinical manifestationsinclude menorrhagia and post partum bleeding.

  3. Groves-Schemata zur Lösung von Anreizproblemen bei der Budgetierung

    OpenAIRE

    Locarek, Hermann

    1992-01-01

    Groves-Schemata zur Lösung von Anreizproblemen bei der Budgetierung / von Günter Bamberg u. Hermann Locarek. - In: Controlling / Klaus Spremann ... (Hrsg.). - Wiesbaden : Gabler, 1992. - S. 657-670. - Auch ersch. als: Arbeitspapiere zur mathematischen Wirtschaftsforschung ; 110

  4. Étude de la toxicité des extraits foliaires d’Euphorbia guyoniana Boiss. et Reut. (Euphorbiaceae chez Schistocerca gregaria (Forskål, 1775 (Orthoptera-Acrididea

    Directory of Open Access Journals (Sweden)

    A. KEMASSI

    2013-03-01

    Full Text Available Study of the toxicity of the crude acetone leaf extract of Euphorbia guyoniana Boiss. and Reut. (Euphorbiaceae in Schistocerca gregaria (Forskål, 1775 (Orthoptera-Acrididea Abstract-This study examines the effect by ingestion of leaf cabbage sprayed with crude acetone extract of Euphorbia guyoniana leaves harvested in the Algerian Sahara on some biological parameters of larvae L5 and adult of desert locusts. The ingestion of cabbage leaves soaked in acetone extract of this Saharan plant generates a 100% mortality in larvae L5 and 66,67% for adult. A significant reduction in food intake was observed in the treated population compared to the control population. It results in a loss of exceptional weight ranging from 26,93% in larvae L5 to 33,09% in adults. Difficulties and anomalies are observed in moulting 16,66% of larvae L5 fed with cabbage leaves soaked in leaf extract of E. guyoniana. Dissection of adult females of the lot processing allows the observation of body regression demonstrating the depressant action of this extract on ovocyte cycle in the desert locust.

  5. Proof of pipeline strength based on measurements of inspection pigs; Festigkeitsnachweis von Pipelines aufgrund der Messergebnisse von Pruefmolchen

    Energy Technology Data Exchange (ETDEWEB)

    De la Camp, H.J.; Feser, G.; Hofmann, A.; Wolf, B.; Schmidt, H. [TUeV Sueddeutschland Bau und Betrieb GmbH, Muenchen (Germany); Herforth, H.E.; Juengling, K.H.; Schmidt, W. [TUeV Anlagentechnik GmbH, Berlin-Schoeneberg (Germany). Unternehmensgruppe TUeV Rheinland/Berlin-Brandenburg

    2002-01-01

    The report is aimed at collecting and documenting the state of the art and the extensive know how of experts and pipeline operators with regard to judging the structural integrity of pipelines. In order to assess the actual mechanical strength of pipelines based on measurement results obtained by inspection pigs, guidance is given for future processing, which eventually can be used as a basis for an industry standard. A literature study of the commercially available types of inspection pigs describes and synoptically lists the respective pros and cons. In essence the report comprises besides check lists of operating data for the pipeline and the pig runs mainly the evaluation of defects and respective calculating procedures. Included are recommendations regarding maintenance planning, verification of defects as well as repetition of pig runs. (orig.) [German] Ziel des Berichtes ist die Erfassung und Dokumentation zum derzeitigen Stand der Technik und des vorhandenen umfangreichen Know-how von Sachverstaendigen und Pipelinebetreibern auf dem Gebiet der sicherheitstechnischen Beurteilung von Pipelines. Fuer den Festigkeitsnachweis von Pipelines aufgrund der Messergebnisse von Pruefmolchen wurde ein Leitfaden als Basis fuer die zukuenftige Vorgehensweise erstellt, der eventuell die Grundlage eines normativen Regelwerkes bilden kann. In einer Literaturstudie wurden die auf dem Markt befindlichen Pruefmolchtypen zusammenfassend beschrieben und ihre Vor- und Nachteile tabellarisch gegenuebergestellt und bewertet. Neben der Erstellung von Checklisten fuer notwendige Daten zum Betrieb der Pipeline und der Molchlaeufe bildet die Fehlerbewertung mit entsprechenden Berechnungsverfahren den Hauptteil dieses Berichtes. Hinweise zur Instandhaltungsplanung (Fehlerverifikation und Molchlaufwiederholung) werden gegeben. (orig.)

  6. Applikation von fermentierter Soja bei Krebspatienten zur Verminderung von Kachexie und Erhöhung der Apoptose - eine prospektive Pilotstudie

    Directory of Open Access Journals (Sweden)

    Jacob U

    2009-01-01

    Full Text Available Kachexie ist eine Begleiterkrankung von Krebs, Aids oder rheumatoider Arthritis. Andere Symptome dieser Erkrankungen sind Depression sowie chronische Erschöpfung. Für alle diese Begleiterkrankungen, die die Lebensqualität der schwererkrankten Patienten negativ beeinflussen, wird eine Erhöhung von Entzündungsmediatoren (z.B. IL-6 und TNF-α verantwortlich gemacht. Für Krebs wird eine Erniedrigung der Apoptose, ausgelöst durch eine Erhöhung von NFκB verantwortlich gemacht. Eine Gabe eines fermentierten Soja-Produktes, das in den USA seit 10 Jahren zur Verbesserung der Lebensqualität von Krebspatienten eingesetzt wird, wurde in einer prospektiven Studie untersucht: Für je 5 Patienten, die unter Prostata-, Ovar- oder Brustkrebs litten, konnte eine signifikante Verminderung von Kachexie, Stress und Depression festgestellt werden. Gleichzeitig konnte man für Prostata- und Ovarkrebs-Patienten eine Erhöhung der Genexpression apoptotischer Marker disseminierter Tumorzellen feststellen. Zusätzlich wurde eine starke Erhöhung der Genexpression des Tumorsuppressorgens p21 festgestellt. Auch wenn die prospektive Studie präliminär ist und die Anzahl der untersuchten Patienten zu klein, so widerspricht sie nicht unserer Annahme, dass es einen direkten Zusammenhang zwischen Krebs und Begleiterkrankungen, besonders der Kachexie, gibt.

  7. "Face to Interface": Zum Problem der Vertrauenskonstitution im Internet am Beispiel von elektronischen Auktionen

    OpenAIRE

    Brinkmann, Ulrich; Seifert, Matthias

    2001-01-01

    Am Beispiel von Internetauktionen geht der Beitrag der Frage nach, welche Rolle Vertrauen bei e-Commerce-Transaktionen spielt und über welche Institutionalisierungsprozesse Vertrauen befördert werden kann. Dazu wird zunächst mit Rückgriff auf den Stand der Forschung ein multidimensionales Verständnis von Vertrauen entwickelt. Anschließend wird die Spezifik von Internetauktionen als Sonderfall von e-Commerce aus der Perspektive der Vertrauensproblematik beleuchtet: beiden Transaktionsparteien ...

  8. Diurnal variation of von Willebrand factor in plasma

    DEFF Research Database (Denmark)

    Timm, Annette; Fahrenkrug, Jan; Jørgensen, Henrik L

    2014-01-01

    BACKGROUND: Quantitation of von Willebrand factor (VWF) in plasma is a central element in assessing von Willebrand disease (VWD). VWF activity is known to vary, which has partly been ascribed to biological and preanalytical variation. However, a possible diurnal expression of VWF has not been...... of light and 9 h of darkness); the plasma concentration of melatonin was used as an internal control to confirm the normal 24-h rhythms of the individual participants. RESULTS: The data, analyzed by rhythmometric statistics, revealed a significant variation (P = 0.02) and total amplitude of 22.6% in VWF...... and VWF and (ii) VWF propeptide and VWF was determined. Taken together, the data suggest changes in release and not in clearance. CONCLUSIONS: Diurnal variation in von Willebrand antigen and activity in plasma represents an important aspect of the biological variation. Standardized time-of-day plasma...

  9. Analyse von Videodokumentationen in der kunstpädagogischen Forschung

    Directory of Open Access Journals (Sweden)

    Anja Mohr

    2001-03-01

    Full Text Available Am Institut für Kunstpädagogik der Justus-Liebig-Universität werden seit 1996 unter der Leitung von Prof. Dr. A. von Criegern Untersuchungen zum kindlichen Bildverhalten am Computer durchgeführt. Aus ersten explorativen Studien ist inzwischen ein Forschungsprojekt entstanden, das auf breiterer theoretisch und empirischer Basis das bildnerische Verhalten von Vor- und frühen Grundschulkindern am Computer untersucht. Entgegen der bisher ergebnisorientierten, eher quantitativ arbeitenden Kinderzeichnungsforschung, stellte das Giessener Team sehr schnell fest, dass der gesamte Malprozess und mehr noch das gesamte ästhetische Verhalten am Computer mit qualitativen Methoden erforscht werden muss. Um diesem Anspruch gerecht zu werden, wurden die Beobachtungs-, Aufzeichnungs- und Analyseverfahren schrittweise optimiert und angepasst. Der Beitrag stellt die Bedeutung der im Projekt angewendeten Form der Videodokumentation für die Erforschung der digitalen Kinderzeichnung dar.

  10. Die Welt der Metadaten im Universum von Repositorien

    Directory of Open Access Journals (Sweden)

    Susanne Blumesberger

    2016-02-01

    Full Text Available Im Rahmen des österreichweiten Projekts „e-Infrastructures Austria“ wird derzeit im Cluster I „Metadatenkomplex aus technischer und nichttechnischer Sicht“ ein Wissensnetzwerk und eine Wissensplattform über Metadaten aufgebaut. Ziel ist die Vorbereitung von Guidelines wie man sowohl im IT-Bereich als auch in Bibliotheken im Bereich von Aufbau und Betrieb eines Repositoriums mit unterschiedlichen Fragen bzgl. Metadaten umgehen kann und soll. Neben Übersichten über die Umsetzungsmöglichkeiten von Linked (Open Data, Metadatenstandards, Best-Practicemodellen, neuen technischen Entwicklungen z. B. im Bereich Controlled Vocabularies, einer Bedarfserhebung von ForscherInnen zum Thema Metadaten für Forschungsdaten und einer Reihe an Use Cases wird auch eine Studie über den derzeitigen Stand der Dinge beim Umgang mit Metadaten an österreichischen Institutionen vorbereitet. Auch die Frage, wie Metadaten möglichst barrierefrei gestaltet sein können, bzw. wie Metadaten dazu beitragen können, dass Objekte für möglichst alle Menschen frei zugänglich sind, wird zentral behandelt. All diese Expertisen, die zu einer Umsetzung von Open Science führen sollen, fließen in die tägliche Praxis ein, zum Beispiel in die Gestaltung von Datamanagementplänen. 2016 wird an der Universität Wien eine Veranstaltung stattfinden, die zur Bewusstseinsbildung für die Wichtigkeit qualitätsvoller Metadaten beitragen soll. ExpertInnen sind dabei eingeladen, miteinander zu diskutieren und Erfahrungen auszutauschen. Es ist geplant, die Ergebnisse, die im Rahmen dieses Clusters entstehen, Open Access zu publizieren.

  11. Contribution to increase coach safety; Die Sicherheit von Omnibussen

    Energy Technology Data Exchange (ETDEWEB)

    Grandel, J.; Mueller, C.F.

    1996-09-01

    The risk of injuries for coach passengers is comparatively low. Nevertheless some periodical occurring serious accidents cause discussions about the coach safety. To objectivize this discussion and to find measures to increase coach safety the Dekra accident research team has started to analyse the real accident events. The basic instrument for this work is the Dekra accident database. The analysis of about 200 real coach accidents shows that single accidents and rollover accidents cause a high risk of serious injuries for the coach occupants. The ejection of unbelted passengers and the collapse of the roof structure are often cause of death and severe injury. To get more detailed information about the kinematic processes during the impact it was necessary to design crash tests based on the results of the real accident investigations. To realize these crash tests Dekra used its own crash centre in Neumuenster. The present study shoes that an integral passenger safety-system consisting of seat, restraint system and body structure is able to increase coach safety. The effectiveness of this system assumes an optimised interacting between every part of the system. (orig.) [Deutsch] Einzelne schwere Busunfaelle sorgen immer wieder fuer negative Schlagzeilen und fuehren zu Diskussionen ueber die Sicherheit von Omnibussen. Fehlendes Grundlagenwissen fuehrt dabei haeufig zu falschen Schlussfolgerungen. Wichtigste Basis fuer eine sachliche Diskussion und die Ableitung von Verbesserungsmassnahmen bildet eine sorgfaeltige und tiefgehende Analyse der realen Omnibusunfaelle. Das Defizit in der grundlegenden Erforschung von Busunfaellen wurde durch eine umfassende Unfallanalyse der Dekra-Unfallforschung beseitigt. Aus dem Realunfallgeschehen abgeleitete und im Dekra-Crash-Zentrum durchgefuehrte Versuche vervollstaendigen das Gesamtbild und geben detaillierte Erkenntnisse bezueglich der Kinematik von Omnibus und Businsassen. Ausgehend von einem bereits hohen Sicherheitsniveau

  12. Der Beitrag von Schreib Peer Tutor_innen zur nachhaltigen Entwicklung von Schreibzentren. Eine empirische Untersuchung auf der Grundlage von Expert_inneninterviews mit Peer Tutor_innen aus deutschen Schreibzentren.

    OpenAIRE

    Poloubotko, Anja

    2014-01-01

    Die vorliegende Arbeit trägt zur Erweiterung der Schreibzentrumstheorie bei, indem die Perspektiven von Peer Tutor_innen auf ihre Rolle im Schreibzentrum und deren Beitrag zur Entwicklung von Schreibzentren beleuchtet werden. Inspiriert durch das Peer Writing Tutor Alumni Research Project (Hughes et al. 2010) und die Erkenntnis von Katrin Girgensohn, dass Peer Tutor_innen eine Schlüsselrolle innerhalb der Schreibzentrumsentwicklung wahrnehmen, sollen im Rahmen der Arbeit folgende Fragen beant...

  13. Die grossen Physiker und ihre Entdeckungen von den fallenden Körpern zu den Quarks

    CERN Document Server

    Segrè, Emilio

    1998-01-01

    Von Galileo Galilei bis zu Richard Feynman und Murray Gell-Mann - von den fallenden Körpern zu den Quarks: Der Physiknobelpreisträger Emilio Segre hat seine ganz persönliche Geschichte der Physik geschrieben. Er erzählt von den großen Gestalten und deren wichtigen Entdeckungen mit großer Anschaulichkeit und Lebendigkeit.

  14. Muuga / Mary von Grünewaldt ; tõlk. Mati Sirkel

    Index Scriptorium Estoniae

    Grünewaldt, Mary von

    2004-01-01

    Leo Zoegelt ostetud Muuga mõisahoone korrastamisest ja uue hoone ehitamisest C. T. von Neffi kunstikogu paigutamise tarbeks. Tütre mälestused. Tõlgitud raamatust: Skizzen und Bilder aus dem Leben Carl Timoleon von Neff / Mary von Grünewaldt. Darmstadt, 1887

  15. „Der Einsatz von handlungs-, erfahrungs- und erlebnisorientierten Methoden in der Lehrerinnen- und Lehrerfortbildung von pädagogischen Führungskräften zur Initiierung von Lernen – Studien zur Verknüpfung von Erfahrung, Reflexion und Transfer“

    OpenAIRE

    Post, Eva - Maria

    2010-01-01

    Bei der Dissertation handelt es sich um eine Studie zum Einsatz von handlungs-, erfahrungs- und erlebnisorientierten Methoden. Diese wurden in der Lehrerinnen- und Lehrerfortbildung von pädagogischen Führungskräften untersucht und hinsichtlich ihrer Initiierung von Lernen überprüft. Dazu wurden der Transfer, die Wirksamkeit und die Nachhaltigkeit in Bezug auf die angebotenen Verfahren beschrieben und ausgewertet.

  16. Dr. Space the life of Wernher von Braun

    CERN Document Server

    Ward, Bob

    2013-01-01

    Written by veteran aerospace journalist Bob Ward, who spent years investigating his subject, this biography presents a revealing but even-handed portrait of the father of modern rocketry. As he chronicles Wernher von Braun's life, Ward explodes many myths and misconceptions about the controversial genius who was a hero to some, a villain to others. The picture of von Braun that emerges is of a brilliant scientist with limitless curiosity and a drive to achieve his goals at almost any price from, developing the world's first ballistic missile used against the Allies in World War II to help

  17. An ELISA for the quantitation of von Willebrand Factor

    DEFF Research Database (Denmark)

    Vinholt, Pernille Just; Overgaard, Martin; Diederichsen, Axel Cosmus Pyndt

    2013-01-01

    BACKGROUND: Von Willebrand factor (VWF) is pivotal in arterial thrombosis, and osteoprotegerin (OPG) is besides being a bone protein also related to cardiovascular diseases. OPG can bind VWF, but the significance of this interaction is not known. OBJECTIVES: The aim was to develop an assay...... for measurement of von Willebrand factor-osteoprotegerin complex (VWF:OPG) in human plasma. Furthermore, the significance of VWF:OPG complex as a marker of cardiovascular disease (CVD) was evaluated. PATIENTS/METHODS: A sandwich ELISA for quantification of VWF:OPG was developed using a polyclonal rabbit anti...

  18. The smooth entropy formalism for von Neumann algebras

    Energy Technology Data Exchange (ETDEWEB)

    Berta, Mario, E-mail: berta@caltech.edu [Institute for Quantum Information and Matter, California Institute of Technology, Pasadena, California 91125 (United States); Furrer, Fabian, E-mail: furrer@eve.phys.s.u-tokyo.ac.jp [Department of Physics, Graduate School of Science, University of Tokyo, Tokyo, Japan and Institute for Theoretical Physics, Leibniz University Hanover, Hanover (Germany); Scholz, Volkher B., E-mail: scholz@phys.ethz.ch [Institute for Theoretical Physics, ETH Zurich, Zurich (Switzerland)

    2016-01-15

    We discuss information-theoretic concepts on infinite-dimensional quantum systems. In particular, we lift the smooth entropy formalism as introduced by Renner and collaborators for finite-dimensional systems to von Neumann algebras. For the smooth conditional min- and max-entropy, we recover similar characterizing properties and information-theoretic operational interpretations as in the finite-dimensional case. We generalize the entropic uncertainty relation with quantum side information of Tomamichel and Renner and discuss applications to quantum cryptography. In particular, we prove the possibility to perform privacy amplification and classical data compression with quantum side information modeled by a von Neumann algebra.

  19. CHANGES OF VON WILLEBRAND FACTOR DURING PREGNANCY IN WOMEN WITHOUT AND WITH VON WILLEBRAND DISEASE

    Directory of Open Access Journals (Sweden)

    Giancarlo Castaman

    2013-07-01

    Full Text Available Delivery in von Willebrand disease (VWD represents a significant hemostatic challenge because of the variable pattern of changes observed during pregnancy of von Willebrand factor (VWF  and factor VIII (FVIII, the protein carried by VWF. The wide heterogeneity of phenotypes and of the underlying pathophysiological mechanisms associated with this disorder prompt a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at time of parturition. VWF and FVIII increase significantly during pregnancy in normal women, already within the first trimester, reaching levels by far > 100 U/dL by the time of parturition. In women with VWD, levels at baseline of VWF and FVIII > 30 U/dL are usually associated with a high likelihood to achieve normal levels at the end of pregnancy and specific anti-hemorrhagic prophylaxis is seldom required. Women with basal level < 20 U/dL usually have a poor increase since most of these women carry mutations associated with increased VWF clearance or are compound heterozygous for different VWF mutations which prevent the achievement of satisfactory hemostatic levels. While women with mutations associated with increased clearance show a full, albeit transitory correction of their hemostatic deficiency after desmopressin administration, compound heterozygous need replacement therapy because they do not respond well to this agent. Patients with abnormal VWF:RCo/VWF:Ag ratio at baseline (e.g. < 0.6, typically associated with type 2 VWD, maintain the abnormality throughout pregnancy and VWF:RCo usually does not attain safe levels ³ 50 U/dL. These women require replacement therapy with VWF-FVIII concentrates. Delayed post-partum bleeding may occur when replacement therapy is not continued for some days. Tranexamic acid may be useful at discharge to avoid excessive lochia.

  20. Von-Neumann and Beyond: Memristor Architectures

    KAUST Repository

    Naous, Rawan

    2017-05-01

    An extensive reliance on technology, an abundance of data, and increasing processing requirements have imposed severe challenges on computing and data processing. Moreover, the roadmap for scaling electronic components faces physical and reliability limits that hinder the utilization of the transistors in conventional systems and promotes the need for faster, energy-efficient, and compact nano-devices. This work thus capitalizes on emerging non-volatile memory technologies, particularly the memristor for steering novel design directives. Moreover, aside from the conventional deterministic operation, a temporal variability is encountered in the devices functioning. This inherent stochasticity is addressed as an enabler for endorsing the stochastic electronics field of study. We tackle this approach of design by proposing and verifying a statistical approach to modelling the stochastic memristors behaviour. This mode of operation allows for innovative computing designs within the approximate computing and beyond Von-Neumann domains. In the context of approximate computing, sacrificing functional accuracy for the sake of energy savings is proposed based on inherently stochastic electronic components. We introduce mathematical formulation and probabilistic analysis for Boolean logic operators and correspondingly incorporate them into arithmetic blocks. Gate- and system-level accuracy of operation is presented to convey configurability and the different effects that the unreliability of the underlying memristive components has on the intermediary and overall output. An image compression application is presented to reflect the efficiency attained along with the impact on the output caused by the relative precision quantification. In contrast, in neuromorphic structures the memristors variability is mapped onto abstract models of the noisy and unreliable brain components. In one approach, we propose using the stochastic memristor as an inherent source of variability in

  1. Einfluss von Umweltbedingungen und Entwicklungsstadium auf Ertragsparameter und sekundäre Pflanzeninhaltsstoffe von Zitronenmelisse (Melissa officinalis L.

    Directory of Open Access Journals (Sweden)

    Russo, Marco

    2014-09-01

    Full Text Available Um die Qualität von Arznei- und Gewürzpflanzen langfristig sichern zu können, ist eine genauere Kenntnis der sie beeinflussenden Faktoren von Interesse. Am Beispiel der Zitronenmelisse (Melissa officinalis L. wurden in zwei Feldversuchen an unterschiedlichen Standorten die Einflüsse der Faktoren Lichtintensität, Sorte und Erntezeitpunkt auf Ertragsparameter sowie sekundäre Pflanzeninhaltsstoffe untersucht. Es konnten teilweise deutliche Effekte der unterschiedlichen Lichtbedingungen auf die Gesamtphenole und die antioxidative Kapazität beobachtet werden, die zum Teil signifikanten Wechselwirkungen zwischen den Prüffaktoren unterlagen.

  2. The Microstructure Organization and Functional Peculiarities of Euphorbia paralias L. and Polygonum maritimum L. – Halophytic Plants from Dunes of Pomorie Lake (Bulgaria

    Directory of Open Access Journals (Sweden)

    I.V. Kosakivska

    2017-05-01

    Full Text Available The aim of this research was to investigate the leaf surface microstructure, pigments spectrum, hormones status and lipids composition of halophytes Polygonum maritimum L. and Euphorbia paralias L. that grow under natural conditions on the dunes of Pomorie Lake, (Bulgaria. It was shown that the existence in saline and dry soils provided among others adaptive mechanisms by specific microstructure of leaf. The adaxial and abaxial surfaces of P. maritimum leaves are covered with a dense layer of cuticle wax, stomata are located on the leaf both sides below the cuticle level. In E. paralias the cuticle is also well developed on the adaxial surface of leaf laminas. The epidermis of the leaf lower side is covered with a less dense cuticle layer formed by large wax crystals. This plant has stoma pores only on the abaxial side of small leaves below the cuticle level and they are surrounded with hump-shaped cuticle constructions. A high amount of carotenoids (as compared with that of chlorophylls in P. maritimum leaves indicates that these pigments have a light-collecting function and could transfer an additional energy to chlorophylls. The high performance liquid chromatography method has been used to provide a qualitative and quantitative analysis of hormones. It was shown that in leaves of E. paralias and P. maritimum free abscisic (ABA and conjugated indole-3-acetic (IAA acids prevailed. A high level of active ABA is correlated with the salt tolerance and ability to survive and grow in stress conditions. A high level of conjugated form of IAA demonstrated that activity of this hormone is limited. The cytokinins qualitative and quantitative analyses demonstrated that in E. paralias leaves zeatin forms dominated, and the level of inactive cytokinins (cis-zeatin and zeatin-O-glucoside was much higher than that of active ones (trans-zeatin and zeatin riboside. P. maritinum leaves contained a significant quantity of isopentenyl forms

  3. A natural component from Euphorbia humifusa Willd displays novel, broad-spectrum anti-influenza activity by blocking nuclear export of viral ribonucleoprotein

    Energy Technology Data Exchange (ETDEWEB)

    Chang, So Young; Park, Ji Hoon [Respiratory Viruses Research Laboratory, Discovery Biology Department, Institut Pasteur Korea, 16, Daewangpangyo-ro 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-400 (Korea, Republic of); Kim, Young Ho; Kang, Jong Seong [College of Pharmacy, Chungnam National University, Daejeon, 305-764 (Korea, Republic of); Min, Ji-Young, E-mail: jiyoung.min@ip-korea.org [Respiratory Viruses Research Laboratory, Discovery Biology Department, Institut Pasteur Korea, 16, Daewangpangyo-ro 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-400 (Korea, Republic of)

    2016-03-04

    The need to develop anti-influenza drugs with novel antiviral mechanisms is urgent because of the rapid rate of antigenic mutation and the emergence of drug-resistant viruses. We identified a novel anti-influenza molecule by screening 861 plant-derived natural components using a high-throughput image-based assay that measures inhibition of the influenza virus infection. 1,3,4,6-tetra-O-galloyl-β-D-glucopyranoside (TGBG) from Euphorbia humifusa Willd showed broad-spectrum anti-influenza activity against two seasonal influenza A strains, A/California/07/2009 (H1N1) and A/Perth/16/2009 (H3N2), and seasonal influenza B strain B/Florida/04/2006. We investigated the mode of action of TGBG using neuraminidase activity inhibition and time-of-addition assays, which evaluate the viral release and entry steps, respectively. We found that TGBG exhibits a novel antiviral mechanism that differs from the FDA-approved anti-influenza drugs oseltamivir which inhibits viral release, and amantadine which inhibits viral entry. Immunofluorescence assay demonstrated that TGBG significantly inhibits nuclear export of influenza nucleoproteins (NP) during the early stages of infection causing NP to accumulate in the nucleus. In addition, influenza-induced activation of the Akt signaling pathway was suppressed by TGBG in a dose-dependent manner. These data suggest that a putative mode of action of TGBG involves inhibition of viral ribonucleoprotein (vRNP) export from the nucleus to the cytoplasm consequently disrupting the assembly of progeny virions. In summary, TGBG has potential as novel anti-influenza therapeutic with a novel mechanism of action. - Highlights: • The plant-derived natural product TGBG has broad-spectrum antiviral activity against seasonal influenza A and B viruses. • TGBG has a novel anti-viral mechanism of action that from differs from the currently available anti-influenza drugs. • TGBG hinders nuclear export of the influenza virus ribonucleoprotein (v

  4. Proteomics in der modernen Toxikologie : Identifizierung, Charakterisierung und Prävalidierung von Protein-Biomarkern zur verbesserten Vorhersage von Leberkanzerogenese

    OpenAIRE

    Fella, Kerstin

    2006-01-01

    Die heutige moderne Toxikologie ist dem 3-R-Prinzip (Russel und Burch, 1959), einem Konzept zur Verminderung und Verkürzung von Tierversuchen, verpflichtet. Allerdings stellt insbesondere die für die Zulassung und Registrierung neuer Arzneistoffe oder Chemikalien behördlich geforderte Prüfung von Substanzen auf kanzerogene Eigenschaften immer noch einen langwierigen Prozess mit einem hohen Bedarf an Versuchstieren dar. Daher sollte unter dem Einsatz von Methoden der Proteomforschung eine Iden...

  5. Einfluss von Futtermitteln und der Fütterungsstrategie auf die Fischproduktion und die Produktqualität von ökologischen Fischereierzeugnissen

    OpenAIRE

    Reiter, Reinhard; Benedikt, Frenzl; Schmidt, Gregor; Karl, Horst; Manthey-Karl, Monika

    2011-01-01

    Im Rahmen eines vom Bundesministerium für Ernährung, Landwirtschaft und Verbraucherschutz (BMELV) finanzierten und von der Bundesanstalt für Landwirtschaft (BLE) betreuten Projektes wurde der Einfluss von Futtermitteln und der Fütterungsstrategie auf die Fischproduktion und die Produktqualität von ökologischen Fischereierzeugnissen untersucht. Für die Untersuchungen wurden Bachforellen (Salmo trutta fario L.) und Seesaiblinge (Salvelinus alpinus L.) unter den Produktionsbedingungen eines ...

  6. Geschlechteridentitäten von Jugendlichen im Kontext von Social Media : Jahrestagung der Fachstelle Gender NRW (FUMA) am 26. Juni 2014 in der Volkshochschule Düsseldorf

    OpenAIRE

    Richter, Susanne

    2015-01-01

    "Auf der Tagung der Fachstelle Gender NRW (FUMA) 'Geschlechteridentitäten von Jugendlichen im Kontext von Social Media', die am 26.06.2014 in Düsseldorf stattfand, stand der Umgang mit neuen Medien im Mittelpunkt. Diskutiert wurden die Praktiken von Jugendlichen in sozialen Netzwerken und die Herausforderungen, die sich hieraus für Mitarbeitende der Kinder- und Jugendhilfe ergeben. Dabei wurde auch der Frage nach Auswirkungen auf Geschlecht und Geschlechtsidentitäten nachgegangen." (Autorenre...

  7. Untersuchungen zur Gentoxizität von Acrylamid in Abhängigkeit von der Cytochrom P450 2E1 Aktivität in humanen Hepatomzellen

    OpenAIRE

    Völkel, Yvonne

    2012-01-01

    Acrylamid ist eine von der IARC als möglicherweise karzinogen eingestufte Substanz, welche vor allem über Zigarettenrauch und kohlenhydratreiche Nahrungsmittel vom Menschen aufgenommen wird. In der vorliegenden Arbeit wurde die Gentoxizität von Acrylamid in HepG2-Zellen mit Hilfe der Einzelzellgelelektrophorese (Cometassay) untersucht. Weiterhin wurde der Einfluss von Ethanol, welches Cytochrom P 450 2E1 induziert, auf die durch Acrylamid hervorgerufene DNA-Migration betrachtet. Acryla...

  8. Die Mediatisierung professionellen Handelns. Zur Notwendigkeit von Handlungskompetenzen im Kontext digitaler Medien in der Sozialen Arbeit

    Directory of Open Access Journals (Sweden)

    Christian Helbig

    2017-04-01

    Full Text Available Digitale Medien durchdringen sowohl den Alltag von Adressat/innen als auch die Institutionen und Organisationen Sozialer Arbeit und in der Folge das professionelle Handeln von Fachkräften. Diese Entwicklungen sind vor dem Hintergrund gesellschaftlicher Teilhabe und somit im Kontext individueller Herausforderungen zu betrachten. Um weder den Anschluss an die Lebenswelten ihrer Adressat/innen zu verlieren, noch institutionelle Ausgrenzungsprozesse zu fördern, ist eine Professionalisierung der Sozialen Arbeit im Kontext von digital vernetzten Medien notwendig. Dies erfordert sowohl die Herausbildung von kritischer Medienkompetenz als auch von medienpädagogischen Handlungskompetenzen.

  9. The Influence of Field Marshal Colmar Von Der Goltz on Ottoman Military Effectiveness in Mesopotamia: December 1915 to April 1916

    Science.gov (United States)

    2012-02-23

    the Ottoman Fifth Army was activated to defend the Dardanelles, and the Ottomans gave Limon von Sanders command. With Limon von Sanders’ move to...Fifth Army, von der Goltz took command of the First Army and the German military mission which were both previously commanded by Limon von Sanders.51

  10. Molecular characterization of exon 28 of von Willebrand's factor ...

    African Journals Online (AJOL)

    Background: Polymorphisms in von Willebrand factor (VWF) gene are an important contributor to the expression of VWF gene and differences in ethnic distribution of these single nucleotide polymorphisms (SNPs) exists. Aims: Our objective was to molecularly characterize the exon 28 of the VWF gene in the three major ...

  11. Lars von Trier ja kombekuse riismed / Kadri Kõusaar

    Index Scriptorium Estoniae

    Kõusaar, Kadri, 1980-

    2011-01-01

    Taani filmilavastaja Lars von Trieri Cannes'is persona non grata'ks kuulutamisest tema filmi "Melanhoolia" esilinastusele järgnenud pressikonverentsil öeldu pärast. Autor ja tema teos tuleb hoida lahus. Trieri filmid jäävad sama raputavateks meistriteosteks, kui nad olid enne

  12. Playing the Waves : Lars von Trier's Game Cinema

    NARCIS (Netherlands)

    Simons, Jan

    2007-01-01

    Dogma95 werd toegejuicht als een Europees alternatief voor de Hollywoodblockbuster. Voor veel critici en filmliefhebbers is Dogma95 gaan staan voor de begrippen waarmee de kunstzinnige film gebruikelijk in verband wordt gebracht: low budget en realisme. Von Triers benadering van filmen voert film

  13. Ueber die von Prof. Dr. A. Gerstaecker beschriebenen Ascalaphidae (Neuroptera)

    NARCIS (Netherlands)

    Weele, van der H.W.

    1906-01-01

    In den Mitth. des naturw. Ver. für Neuvorpomm. und Rügen, Band XVI, XIX, XX. und XXV, hat Gerstaecker eine Reihe neuer Arten Planipennia beschrieben, von welchen ich durch die Freundlichkeit seines Nachfolgers Prof. G. W. Müller in Greifswald die Ascalaphiden zur Untersuchung bekommen habe. Obschon

  14. Mollusken aus posttertiären Schichten von Celebes

    NARCIS (Netherlands)

    Schepman, M.M.

    1912-01-01

    Die im Folgenden behandelten Mollusken stammen aus der Nähe von Kajoe ragi auf Celebes, woselbst sie durch R. FENNEMA aus denselben Schichten ausgelesen wurden, aus denen früher durch J. G. DE MAN einige brachyure Krebse beschrieben sind. Es darf deswegen betreffs näherer Angaben über die Herkunft

  15. Sakslased tulevad! Ärevad ajad Tallinnas Von Krahli Teatris

    Index Scriptorium Estoniae

    2001-01-01

    Von Krahli Teater ja Showcase Beat Le Mot valmistuvad oma esimeseks koostööprojektiks - lavastuseks "Pirates", kus osalevad mõlema teatri näitlejad ja tehnikud. Ühisprojekti toetavad Goethe Instituut, Hamburgi Linnavalitsus ja Eesti Kultuurkapital

  16. Von Economo neurons: A review of the anatomy and functions ...

    African Journals Online (AJOL)

    Von Economo neurons (VENs) are large bipolar neurons found in the anterior cingulate, fronto‑insular, and dorsolateral prefrontal cortices of great apes and the humans. VENs are defined by their thin, elongated cell body, and long dendrites projecting from the apical and basal ends. These neurons are mostly present in ...

  17. Alexander von Humboldt's invention of the natural landscape

    NARCIS (Netherlands)

    Kwa, C.

    2005-01-01

    Landscape took on a new meaning through the new science of plant geography of Alexander von Humboldt (1769-1857). In the seventeenth and eighteenth centuries, "landscape" was foremost a painterly genre. Slowly, painted landscapes came to bear on natural surroundings, but by 1800 it was still not

  18. Spin–momenta entanglement in moving frames: Properties of von ...

    Indian Academy of Sciences (India)

    disentangled) as seen by moving observers, is used to investigate the properties of von Neumann entropy, as a measure of spin–momentum entanglement. To do so, we partition the total Hilbert space into momentum and spin subspaces so that the ...

  19. Seminario para el estudio de carl von clausewitz

    OpenAIRE

    Mesa, Darío

    2008-01-01

    Este es el programa del seminario que a propuesta y bajo la dirección del profesor Darío Mesa se realizó en el Departamento de Sociología, entre marzo y septiembre de 1981 sobre el libro de La Guerra del Militar y Teórico Prusiano Cari Von Clausewitz (178

  20. Seminario para el estudio de Carl Von Clausewitz

    Directory of Open Access Journals (Sweden)

    Darío Mesa

    2000-01-01

    Full Text Available Este es el programa del seminario que a propuesta y bajo la dirección del profesor Darío Mesa se realizó en el Departamento de Sociología, entre marzo y septiembre de 1981 sobre el libro de La Guerra del Militar y Teórico Prusiano Cari Von Clausewitz (178

  1. Molecular characterization of exon 28 of von Willebrand's factor ...

    African Journals Online (AJOL)

    2016-05-12

    May 12, 2016 ... two probable cases among 95 patients with hemophilia A and 11 with hemophilia B between 1980 and 1986, but full investigation and family studies were not performed. In. Nigeria, we have been unable to find documented cases of. Molecular characterization of exon 28 of von Willebrand's factor gene in ...

  2. Systematisierung und Evaluierung von Clustering-Verfahren im Information Retrieval

    OpenAIRE

    Kürsten, Jens

    2006-01-01

    Im Rahmen der vorliegenden Diplomarbeit werden Verfahren zur Clusteranalyse sowie deren Anwendungsmöglichkeiten zur Optimierung der Rechercheergebnisse von Information Retrievalsystemen untersucht. Die Grundlage der vergleichenden Evaluation erfolgversprechender Ansätze zur Clusteranalyse anhand der Domain Specific Monolingual Tasks des Cross-Language Evaluation Forums 2006 bildet die systematische Analyse der in der Forschung etablierten Verfahren zur Clusteranalyse. Die Implementierung ...

  3. Update zum klinischen Einsatz von Inhibitoren mutierter Phosphokinasen beim Melanom.

    Science.gov (United States)

    Cosgarea, Ioana; Ritter, Cathrin; Becker, Jürgen C; Schadendorf, Dirk; Ugurel, Selma

    2017-09-01

    Die Behandlungsstrategie beim metastasierten Melanom hat sich mit der Identifizierung therapeutisch angreifbarer molekularer Zielstrukturen innerhalb zellulärer Signalwege radikal geändert. Durch die Zulassung von Substanzen, die gezielt an den zentralen Schaltmolekülen, den Phosphokinasen, angreifen, können diese Signalwege selektiv abgeschaltet werden. Dies ist insbesondere bei denjenigen Tumoren von Interesse, deren Signalwege durch aktivierende Mutationen der für die Schaltmoleküle kodierenden Gene konstitutiv aktiviert sind. Aktuell ist diese therapeutische Strategie insbesondere für Patienten bedeutsam, deren Melanome eine Mutation im BRAF-Gen aufweisen. Diese Patienten können durch eine Kombinationstherapie aus Inhibitoren der Phosphokinasen BRAF und MEK langfristig mit sehr guter Krankheitskontrolle behandelt werden. Unter dieser Kombinationstherapie wird aktuell ein progressionsfreies Überleben von über zehn Monaten und ein Gesamtüberleben von mehr als zwei Jahren bei guter Lebensqualität erzielt. Da unter längerfristiger Therapie mit Kinaseinhibitoren jedoch bei einem Großteil der Patienten eine Resistenzbildung auftritt, sind aktuelle klinische Therapiestudien auf die Suche nach geeigneten Kombinationspartnern unter Blockierung anderer Signalwege oder unter Aktivierung der T-Zell-vermittelten Immunantwort ausgerichtet. Der vorliegende Übersichtsartikel stellt sowohl die aktuell verfügbaren als auch die in der klinischen Testung befindlichen zukünftigen Optionen der zielgerichteten Therapie des Melanoms dar. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  4. Theodore von Kármán–Rocket Scientist

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 10; Issue 8. Theodore von Kármán – Rocket Scientist. Jaywant H Arakeri. Article-in-a-Box Volume 10 Issue 8 August 2005 pp 2-3. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/010/08/0002-0003 ...

  5. Lars von Triers fornyelse af filmen 1984-2014

    DEFF Research Database (Denmark)

    Thomsen, Bodil Marie Stavning

    Bogen undersøger Lars von Triers affektskabende og etisk involverende stil med udgangspunkt i hans værker over en 30-årig periode (1984-2014). Centralt i bogens læsninger står væsentlige analytiske begreber som det haptiske, det affektive, det diagrammatiske og det signaletiske materiale, der med...

  6. C. J. Ebhardi ja Balthasar von Campenhauseni projektid / Toivo Meikar

    Index Scriptorium Estoniae

    Meikar, Toivo, 1947-

    2005-01-01

    Lisatud: C. J. Ebhardi Eesti- ja Liivimaa metsa- ja jahiseaduse projekt (valmis hiljemalt aastaks 1770), lk. 199-222 ; Härra maanõuniku parun von Campenhauseni ettepanekud kõikide metsade nõuetekohaseks korralduseks (4. juuli 1778), lk. 223-233

  7. Myriopoden von Ambon und anderen Inseln Der Banda-See

    NARCIS (Netherlands)

    Attems, C.

    1927-01-01

    Dr. Kopstein auf Ambon hat dem Leidener Museum eine Anzahl von ihm gesammelter Myriopoden gesandt, deren Bestimmung ich übernommen habe. Das Material ist nicht gerade reichhaltig, zumeist nicht gut conserviert und umfasst lange nicht die gesammte dortige Fauna; trotzdem war auch etwas neues darin,

  8. Krahv Alexander von Keyserling / Sirje Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Sirje, 1947-

    2002-01-01

    Alexander Friedrich Michael Lebrecht Arthur Nicolaus James von Keyserlingi (1815-1891) elust ja teaduslikest ekspeditsioonidest Venemaal ning tegevusest Eestis Raikküla mõisnikuna, loodusteadlasena, Eestimaa rüütelkonna peamehena, eesti talupoegade olukorra parandajana, Tartu õpperingkonna kuraatorina, maanõunikuna, tema pereelust ja lastest

  9. Goethe und Alexander von Humboldt - Bau und Geschichte der Erde

    Directory of Open Access Journals (Sweden)

    Wolf von Engelhardt

    2001-10-01

    Full Text Available Article in German, Abstracts in English and German. An account is given on Goethe's criticism of Alexander von Humboldt's writings: "Ueber den Bau und die Wirkungsart der Vulkane in den verschiedenen Erdstrichen" (Berlin 1823 und "Fragmens de géologie et de climatologie asiatique" (Paris 1831.

  10. Die Eintheilung der versteinerungsführenden Sedimente von Java

    NARCIS (Netherlands)

    Martin, K.

    1899-01-01

    Die als Jungtertiär (m 1, m 2 und m 3) kartirten Sedimente von Java und Madura nehmen ± 38% der ganzen Oberfläche dieser Eilande ein, während sich die posttertiären Ablagerungen mit reichlich 33%, die vulkanischen ¹) Bildungen mit fast 28%, alle vorneogenen Gesteine aber nur mit reichlich 1%

  11. Primary carcinoma of the lung in von Recklinghausen neurofibromatosis

    Directory of Open Access Journals (Sweden)

    Gupta K

    2009-01-01

    Full Text Available von Recklinghausen neurofibromatosis (NF-1 is the most common inherited syndrome predisposing to neoplasia, particularly neural crest-derived tumors. However, lung malignancies reported in association with neurofibromatosis are sparse. We present a case of a 48-year-old man with NF-1 that manifested as carcinoma of lung, in order to discuss the linkage between these two entities.

  12. Von Kármán between Aachen and Pasadena

    Science.gov (United States)

    Krause, Egon; Kalkmann, Ulrich

    2013-05-01

    In the Introduction the reader is referred back to the academic ceremonials held after Theodore von Kármán's death in Aachen in May 1963. His work as the first director of the Aerodynamisches Institut (Institute of Aerodynamics) of the RWTH Aachen University of Technology from 1913 on and his initiative to re-establish international cooperation after World War I, resulting in the International Union of Theoretical and Applied Mechanics (IUTAM), are commented on. The following chapter describes von Kármán's relation to his former teacher Ludwig Prandtl. Some of von Kármán's scientific contributions during his time in Aachen are briefly reviewed. Thereafter, his first contacts to the California Institute of Technology are covered. Finally, the scientific and political circumstances, which led to von Kármán's decision to leave Germany in the early thirties, are elucidated in some detail. The English translation of the titles of the Aachen papers is given in Appendix I.

  13. Bemerkungen zu Alexander von Humboldts Russland-Tagebuch

    Directory of Open Access Journals (Sweden)

    Petra Werner

    2008-04-01

    Full Text Available Article in German, Abstracts in English and GermanIn this study the fragment of Alexander von Humboldt’s Siberian personal diary of 1829 is introduced. The evaluation is focussed on Humboldt’s remarks about mineral resources, especially gold and diamonds. Also mentioned are results which Humboldt recorded about geographical, botanical, meteorological, zoological and ethnological questions.

  14. Über die Gyriniden (Col.) von Guiana

    NARCIS (Netherlands)

    Ochs, Georg

    1962-01-01

    Von 14 Taumelkäfer-Arten, die bislang für Guiana nachgewiesen waren, kannte man aus Suriname lediglich 2. Dank der Sammeltätigkeit der Naturwissenschaftlichen Suriname Expedition 1949 in den Nassau Gebergte erhöhen sich diese Zahlen um 3 neue Arten und 2 Unterarten, die hierunter beschrieben werden,

  15. Die Rolle von Osteoklasten bei der arthritischen Knochenerosion

    Directory of Open Access Journals (Sweden)

    Schett G

    2003-01-01

    Full Text Available Knöcherne Erosionen stellen eine wesentliche Ursache für die funktionelle Einschränkung von Patienten mit rheumatoider Arthritis dar. Bis vor kurzem war über den Pathomechanismus dieser Veränderungen nur wenig bekannt. Dieser Review faßt die letzten Erkenntnisse über die Ausbildung einer Knochenschädigung bei entzündlichen Gelenkerkrankungen zusammen und fokussiert insbesondere die Rolle von Osteoklasten. Es wird ein Überblickzu den Hinweisen für eine Präsenz von Osteoklasten im entzündlich veränderten Gelenk gegeben. Weiters werden die Faktoren diskutiert, die die Osteoklastogenese im Rahmen einer Gelenkentzündung aktivieren können. Hier wird im besonderen auf die Rolle von Receptor-Activator of Nuclear Factor Kappa B Ligand (RANKL eingegangen. Im weiteren werden die Auswirkungen einer Osteoklastenhemmung in den verschiedenen Arthritismodellen zusammengefaßt und Möglichkeiten einer therapeutischen Nutzung bei rheumatoider Arthritis diskutiert.

  16. Linckia rosenbergi Von Martens, a Synonym of L. laevigata (L.)

    NARCIS (Netherlands)

    Engel, H.

    1942-01-01

    When Clark (1921) cleared the genus Linckia from superfluous synonyms, he could give no opinion on Linckia rosenbergi Von Martens 1866, p. 63 from Amboina. The unique holotype was in the Berlin Museum and hence not easily accessible to him, the species had not been described again. In his key Clark

  17. Ernst von Glasersfeld's Radical Constructivism and Truth as Disclosure

    Science.gov (United States)

    Joldersma, Clarence W.

    2011-01-01

    In this essay Clarence Joldersma explores radical constructivism through the work of its most well-known advocate, Ernst von Glasersfeld, who combines a sophisticated philosophical discussion of knowledge and truth with educational practices. Joldersma uses Joseph Rouse's work in philosophy of science to criticize the antirealism inherent in…

  18. Einfluss von Ernährungsfaktoren im ersten Lebensjahr auf die Entwicklung von Diabetes- und Zöliakie-assoziierter Autoimmunität

    OpenAIRE

    Huber, Doris

    2005-01-01

    Eine Modulation von Ernährungsfaktoren wurde als möglicher Einflussfaktor auf das Risiko für Typ 1 Diabetes-assoziierte Autoimmunität vermutet. Ziel der Arbeit war es, festzustellen, ob die Stilldauer, die Einführung von industriell hergestellter Säuglingsmilchnahrung, das Zufüttern von Beikost oder der Zeitpunkt der erstmaligen Gabe glutenhaltiger Nahrungsmittel Einfluss auf die Entwicklung von Diabetes- oder Zöliakie-assoziierten Autoantikörper haben. Als Studienkollektiv dienten 1610 Kinde...

  19. Die filmstilistische Darstellung von Klaras Gehbehinderung im Kinderfilm "Heidi"

    Directory of Open Access Journals (Sweden)

    Maria Ohrfandl

    2016-09-01

    Full Text Available Dieser Beitrag soll die Forschungslücke zur Darstellung von Behinderungen speziell im Kinderfilm im deutschsprachigen Raum füllen. Auf Basis einer neoformalistisch orientierten Filmanalyse nach Bordwell und Thompson (2008, wird anhand von drei Filmsequenzen eine mögliche Lesart des Kinderfilms "Heidi" (Marcus 2005 entwickelt, um die filmstilistische Darstellung der Gehbehinderung des Mädchens Klara zu untersuchen. Die Ergebnisse werden mit theoretischen Überlegungen zur Problematik der Begriffsbestimmung von Körperbehinderung sowie zur Mobilität und Selbstbestimmung von Menschen mit Körperbehinderungen in Bezug gesetzt. Dabei zeigt sich im Wesentlichen, dass im Kinderfilm "Heidi" (Marcus 2005 Klaras Gehbehinderung als 'heilbare Krankheit' und der Rollstuhl als Einschränkung von Mobilität begriffen wird. Außerdem unterliegt Klara aufgrund ihrer Körperbehinderung überwiegend der Fremdbestimmung von Erwachsenen. Zur Klärung wahrscheinlicher filmischer Bildungspotenziale werden die Ergebnisse schließlich anhand der von Jörissen und Marotzki (2009 entwickelten Orientierungsdimensionen "Wissens-, Handlungs-, Grenz- und Biographiebezug" diskutiert. This article aims to bridge a knowledge gap by showing ways of representing disabilities in the German children film genre. Using Bordwell and Thomson's (2008 neoformalistically orientated film analysis approach, the movie "Heidi" (Marcus 2005 is analysed. Bordwell and Thompson's (2008 method is applied to three sequences of "Heidi" in order to present an interpretation and to discuss the representation of Clara's walking impediment. The results are then associated with theoretical considerations regarding the mobility and self-determination of people with disabilities and problematic definitions of the term 'physical disability'. It is shown that characters in the children's film "Heidi" (Marcus 2005 regard Clara's walking impediment as a 'curable disease' and the wheelchair as a limitation

  20. Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL produzierende E. coli)

    OpenAIRE

    Kreausukon, Khwanchai

    2011-01-01

    Das Ziel der Studie war, Informationen über den Einsatz von Antibiotika in deutschen Milchkuhherden zu sammeln. Zudem sollte auf das Vorkommen von MRSA und ESBL-produzierenden E. coli in Tankmilchproben untersucht werden. Fragebögen wurden unter den Herdenmanagern von 60 norddeutschen Betrieben (Herdengröße von 25 bis 3000 Tiere) verteilt, die auf freiwilliger Basis an den Untersuchungen teilnahmen. Tankmilchproben wurden in den Betrieben einmalig entnommen und auf das Vorkommen von MRSA u...

  1. Optimierung der Gesichtsklassifikation bei der Erkennung von Akromegalie

    Directory of Open Access Journals (Sweden)

    Frohner R

    2013-01-01

    Full Text Available In vorausgegangenen Studien konnte gezeigt werden, dass eine Gesichtsklassifikation mittels Gesichtsphotographien zur Diagnostik von Akromegalie mit guten Ergebnissen eingesetzt werden kann. In diesem Artikel werden die grundlegende Vorgehensweise der Klassifikation mittels der Software FIDA erläutert sowie Optimierungsansätze mit dem Ziel diskutiert, diese Methode näher an den klinischen Einsatz zu bringen. Die Gesichtsklassifikation basiert auf „Knotenpunkten“, die verteilt über die jeweilige Frontal- und/oder Seitenansicht des Gesichts platziert werden und den so genannten „Graphen“ bilden. Mittels mathematischer Verfahren erfolgt eine Analyse der zugrunde liegenden Textur des Bildes sowie die Auswertung geometrischer Informationen. Untersucht wird, wie sich die Reduktion von als irrelevant eingestuften Knoten auf das Klassifikationsergebnis auswirkt. Ebenso wird untersucht, wie sich neu definierte Knoten, die die typischen morphologischen Veränderungen der akromegalen Erkrankung im Gesicht berücksichtigen, auf die Klassifizierungsergebnisse auswirken. Die interne Validierung erfolgt an einem Datenset bestehend aus 57 an Akromegalie erkrankten Probanden (29 weiblich, 28 männlich sowie 59 Kontrollen (29 weiblich, 30 männlich. Die externe Validierung wird an einer weiteren Stichprobe gemessen, die zum Zeitpunkt der Präsentation auf der Tagung der European Neuroendocrine Association 2012 in Wien 13 akromegale Patienten (7 weiblich, 6 männlich sowie 45 Kontrollen (25 weiblich, 20 männlich umfasste. Die Datenbank wird ständig durch neue Probanden aus verschiedenen Quellen erweitert. Erste Ergebnisse zeigen, dass die Verwendung von Graphen mit reduzierten Knoten und von neuen Sets von Knoten unter Einbeziehung typischer morphologischer Veränderungen des Gesichts die Klassifizierung weiter verbessert. Diese Ergebnisse ermutigen zu weiteren Untersuchungen an einer erweiterten Datenbank.

  2. Eine selbstkonsistente Carleman Linearisierung zur Analyse von Oszillatoren

    Directory of Open Access Journals (Sweden)

    H. Weber

    2017-09-01

    Full Text Available Die Analyse nichtlinearer dynamischer Schaltungen ist bis heute eine herausfordernde Aufgabe, da nur selten analytische Lösungen angegeben werden können. Daher wurden eine Vielzahl von Methoden entwickelt, um eine qualitative oder quantitative Näherung für die Lösungen der Netzwerkgleichung zu erhalten. Oftmals wird beispielsweise eine Kleinsignalanalyse mit Hilfe einer Taylorreihe in einem Arbeitspunkt durchgeführt, die nach den Gliedern erster Ordnung abgebrochen wird. Allerdings ist diese Linearisierung nur in der Nähe des stabilen Arbeitspunktes für hyperbolische Systeme gültig. Besonders für die Analyse des dynamischen Verhaltens von Oszillatoren treten jedoch nicht-hyperbolische Systeme auf, sodass diese Methode nicht angewendet werden kann Mathis(2000. Carleman hat gezeigt, dass nichtlineare Differentialgleichungen mit polynomiellen Nichtlinearitäten in ein unendliches System von linearen Differentialgleichungen transformiert werden können Carleman(1932. Wird das unendlichdimensionale Gleichungssystem für numerische Zwecke abgebrochen, kann bei Oszillatoren der Übergang in eine stationäre Schwingung (Grenzzyklus nicht wiedergegeben werden.In diesem Beitrag wird eine selbstkonsistente Carleman Linearisierung zur Untersuchung von Oszillatoren vorgestellt, die auch dann anwendbar ist, wenn die Nichtlinearitäten keinen Polynomen entsprechen. Anstelle einer linearen Näherung um einen Arbeitspunkt, erfolgt mit Hilfe der Carleman Linearisierung eine Approximation auf einem vorgegebenen Gebiet. Da es jedoch mit der selbstkonsistenten Technik nicht möglich ist, das stationäre Verhalten von Oszillatoren zu beschreiben, wird die Berechnung einer Poincaré-Abbildung durchgeführt. Mit dieser ist eine anschließende Analyse des Oszillators möglich.

  3. Modellierung von Quanteneffekten in einem ladungsbasierten MOS-Transistor-Modell zur Simulation von nanoskalierten CMOS-Analogschaltungen

    Science.gov (United States)

    Stegemann, S.; Xiong, J.; Mathis, W.

    2009-05-01

    Aufgrund der fortschreitenden Miniaturisierung der Bauelemente in CMOS-Schaltungen und den dadurch erreichten Strukturgrößen nehmen quantenmechanische Effekte zunehmenden Einfluss auf die Funktion von Transistoren und damit auf die gesamte Schaltung. Unter Einbeziehung der Energiequantisierung an der Si/SiO2-Grenzfläche wird untersucht, wie sich durch eine Modifikation der Beschreibung des Oberflächenpotenzials die Inversionsladung quantenmechanisch formulieren lässt. Im Hinblick auf den Entwurf und die Simulation von CMOS-Analogschaltungen wird dazu ein ladungsbasiertes MOS-Transistor-Modell zugrunde gelegt. Die sich daraus ergebenden Veränderungen für die Kapazitäten und die Inversionsladung werden dabei für die Modellierung des quasiballistischen Drain-Source-Stromes verwendet. Dazu wird innerhalb dieses Modells ein Streufaktor berechnet, mit dem nanoskalierte MOS-Transistoren mit einer Kanallänge von unter 20 nm simuliert werden können. Ausgehend von Parametern eines CMOS-Prozesses werden mit MATLAB die Einflüsse der quantenmechanischen Effekte bei der Skalierung des Transistors analysiert.

  4. Modellierung von Quanteneffekten in einem ladungsbasierten MOS-Transistor-Modell zur Simulation von nanoskalierten CMOS-Analogschaltungen

    Directory of Open Access Journals (Sweden)

    S. Stegemann

    2009-05-01

    Full Text Available Aufgrund der fortschreitenden Miniaturisierung der Bauelemente in CMOS-Schaltungen und den dadurch erreichten Strukturgrößen nehmen quantenmechanische Effekte zunehmenden Einfluss auf die Funktion von Transistoren und damit auf die gesamte Schaltung. Unter Einbeziehung der Energiequantisierung an der Si/SiO2-Grenzfläche wird untersucht, wie sich durch eine Modifikation der Beschreibung des Oberflächenpotenzials die Inversionsladung quantenmechanisch formulieren lässt. Im Hinblick auf den Entwurf und die Simulation von CMOS-Analogschaltungen wird dazu ein ladungsbasiertes MOS-Transistor-Modell zugrunde gelegt. Die sich daraus ergebenden Veränderungen für die Kapazitäten und die Inversionsladung werden dabei für die Modellierung des quasiballistischen Drain-Source-Stromes verwendet. Dazu wird innerhalb dieses Modells ein Streufaktor berechnet, mit dem nanoskalierte MOS-Transistoren mit einer Kanallänge von unter 20 nm simuliert werden können. Ausgehend von Parametern eines CMOS-Prozesses werden mit MATLAB die Einflüsse der quantenmechanischen Effekte bei der Skalierung des Transistors analysiert.

  5. Zum 215. Gebutstag von Admiral Ferdinand Baron von Wrangell : (29. Dezember 1797 - 25. 25. Mai 1870) / Peter Krienitz

    Index Scriptorium Estoniae

    Krienitz, Peter

    2012-01-01

    Admiral Ferdinand Baron von Wrangellist tema 215. sünniaastapäeva puhul. Silmapaistavast Kirde-Siberi uurijast. Tema poliitilisest tegevusest ja elust Roela mõisas. Ferdinand Baroni poolt seatud viisil tähistati jõulusid Roelas kuni 1944. aasta lõpuni.

  6. Palaeontologische Ergebnisse von Tiefbohrungen auf Java, nebst allgemeineren Studien ueber das Tertiaer von Java, Timor und einiger anderer Inseln

    NARCIS (Netherlands)

    Martin, K.

    1883-01-01

    In Padang auf Sumatra wurde der Zahn eines Elephanten gefunden, welcher mit den typischen Repraesentanten von E. sumatranus in jeder Hinsicht übereinstimmt. Die Art wurde früher bekanntlich mit dem E. indicus Cuv. zusammengeworfen, bis Temminck und vor allem auch Schlegel l. c. die Verschiedenheit

  7. Otto von Habsburg : III maailmasõda on läbi / Otto von Habsburg ; interv. Marianne Mikko

    Index Scriptorium Estoniae

    Habsburg, Otto von, 1912-2011

    2002-01-01

    Otto von Habsburg vastab küsimustele, mis puudutavad Euroopa konvendi presidendi teadet, et Türgi koht ei ole EL-is, Iraagi võimalikku ründamist, Hiina ja Venemaa suhteid, Tšetšeeniat, tshetsheene ja terrorismi, Venemaa, EL-i ja USA suhteid, III maailmasõda, Eesti Vabariigi tulevikku

  8. Bioensaios para identificação de biótipos de Euphorbia heterophylla com resistência múltipla a inibidores da ALS e da PROTOX Greenhouse and laboratory bioassays for identification of Euphorbia heterophylla biotypes with multiple resistance to PROTOX and ALS-inhibiting herbicides

    Directory of Open Access Journals (Sweden)

    M.M. Trezzi

    2006-09-01

    Full Text Available Quatro bioensaios, dois em casa de vegetação e dois em laboratório, foram conduzidos com o objetivo de identificar biótipos de Euphorbia heterophylla (EPHHL com resistência múltipla a inibidores da ALS e da PROTOX. Em casa de vegetação, plantas do biótipo suscetível (S e dos biótipos 4 e 23, suspeitos de resistência múltipla, foram aspergidas com diferentes doses de imazethapyr e fomesafen. Nos bioensaios em laboratório, sementes dos biótipos S e 4 foram depositadas em placas de Petri contendo diferentes concentrações dos mesmos herbicidas. Curvas de dose-resposta foram ajustadas, utilizando os modelos logístico e polinomial, respectivamente, para os dados obtidos em casa de vegetação e em laboratório. Em casa de vegetação, o fator de resistência (FR a imazethapyr para o biótipo 4 foi superior a 24, enquanto para o biótipo 23 ele foi de 15. Os FRs a fomesafen foram, respectivamente, de 62 e 39, para os mesmos biótipos. Em um período de 144 horas, concentrações de imazethapyr e fomesafen no bioensaio em laboratório foram capazes de discriminar os crescimentos da parte aérea e radicular dos biótipos de EPHHL com resistência múltipla e S. Os resultados confirmam ser tanto os testes em casa de vegetação quanto os laboratoriais, utilizando placas de Petri, metodologias apropriadas para discriminar biótipos de EPHHL S daqueles com resistência múltipla.Four bioassays were developed under greenhouse and laboratory conditions to identify Euphorbia heterophylla (EPHHL biotypes with multiple resistance to PROTOX and ALS-inhibiting herbicides. In the greenhouse bioassays, plants of a susceptible (S biotype and of two biotypes suspected of multiple resistance (#4 and #23 were sprayed using different levels of the herbicides imazethapyr and fomesafen. The laboratory bioassays consisted of a comparative test between biotypes S and #4, exposed to germination in imazethapyr and fomesafen solutions. Dose

  9. Evaluation of temporal, seasonal and geographic stability of the molluscicidal property of Euphorbia splendens latex Avaliação da estabilidade temporal, estacional e geográfica da ação moluscicida do latex da Euphorbia splendens

    Directory of Open Access Journals (Sweden)

    Virginia Torres Schall

    1992-06-01

    Full Text Available Laboratory tests with aqueous solutions of Euphorbia splendens var. hislopii latex have demonstrated seasonal stability of the molluscicidal principle, with LD90 values of 1.14 ppm (spring, 1.02 ppm (fall, 1.09 ppm (winter, and 1.07 ppm (summer that have been determined against Biomphalaria tenagophila in the field. Assays on latex collected in Belo Horizonte and Recife yielded LD90 values similar to those obtained with the reference substance collected in Rio de Janeiro (Ilha do Governador, demonstrating geographic stability of the molluscicidal effect. The molluscicidal action of aqueous dilutions of the latex in natura, centrifuged (precipitate and lyophilized, was stable for up to 124 days at room temperature (in natura and for up to 736 days in a common refrigerator at 10 to 12ºC (lyophilized product. A 5.0 ppm solution is 100% lethal for snails up to 13 days after preparation, the effect being gradually lost to almost total inactivity by the 30th day. This observation indicated that the active principle is instable. These properties together with the wide distribution of the plant, its resistance and adaptation to the tropical climate, its easy cultivation and the easy obtention of latex and preparation of the molluscicidal solution, make this a promising material for large-scale use in the control of schistosomiasisTestes de laboratório com soluções aquosas do látex da Euphorbia splendens var. hislopii demonstraram uma estabilidade estacional da atividade moluscicida do produto coletado na Ilha do Governador - RJ, encontrando-se as seguintes DL90: 1,14 ppm (primavera; 1,02 ppm (outono; 1,09 ppm (inverno e 1,07 ppm (verão sobre Biomphalaria tenagophila de campo. Ensaios com o látex da planta coletado em Belo Horizonte e Recife, identificaram DL90 semelhantes aos da substância de referência coletada no Rio, demonstrando uma estabilidade geográfica do efeito moluscicida. Usando diluições aquosas do latex in natura, centrifugado

  10. Estudos anatômicos de folhas de espécies de plantas daninhas de grande ocorrência no Brasil: IV - Amaranthus deflexus, Amaranthus spinosus, Alternanthera tenella e Euphorbia heterophylla Leaf anatomical studies in weed species widely common in Brazil: IV - Amaranthus deflexus, Amaranthus spinosus, Alternanthera tenella and Euphorbia heterophylla

    Directory of Open Access Journals (Sweden)

    E.A. Ferreira

    2003-08-01

    Full Text Available Neste trabalho é apresentado um estudo da anatomia das folhas de espécies de plantas daninhas de grande ocorrência no Brasil: Amaranthus deflexus, Amaranthus spinosus, Alternanthera tenella e Euphorbia heterophylla, visando melhor compreensão das barreiras que cada espécie impõe à penetração dos herbicidas e outros compostos utilizados em aplicações foliares. As folhas completamente expandidas do terceiro ao quinto nó foram coletadas de plantas de ocorrência espontânea no campo. Das folhas de cada espécie foram obtidas três amostras da região mediana, com aproximadamente 1 cm², as quais foram utilizadas em estudos da estrutura, clarificação e em observações em microscópio eletrônico de varredura. Todas as espécies avaliadas são anfiestomáticas. As principais barreiras foliares potenciais à penetração de herbicidas observadas nas plantas daninhas A. deflexus e A. spinosus foram, respectivamente, grande espessura da cutícula da face adaxial e da cutícula das duas faces. Já em relação a A. tenella, grande espessura da cutícula das duas faces, elevado teor de cera epicuticular e alta densidade tricomática foram os principais obstáculos potenciais detectados. E. heterophylla apresentou como possíveis principais barreiras foliares à penetração de agroquímicos o alto teor de cera epicuticular, a elevada densidade de laticíferos e a grande espessura da cutícula da face adaxial.This research aimed to study the leaf anatomy of the weed species Amaranthus deflexus, Amaranthus spinosus, Alternanthera tenella and Euphorbia heterophylla, widely known in Brazil, to acquire a better understanding of the barriers each species imposes to herbicide penetration, and to other substances used for leaf spraying. Completely expanded leaves from the third to the fifth nodes were collected from spontaneous plants in the field. Three samples approximately 1cm², were removed from the medium portion of the leaves, from each

  11. Possibilities and limitations of sup 1 H and sup 13 C nuclear magnetic resonance spectroscopy for the identification and the quantitative determination of some naturally occurring carcinogenic risk factors. [Senecio vulgaris; Senecio vernalis; Senecio jacobaea; Euphorbia ingens

    Energy Technology Data Exchange (ETDEWEB)

    Pieters, L.

    1988-01-01

    The aim of this work was to develop a phytochemical screening method for some selected carcinogenic or tumor-promoting principles in higher plants. The pyrrolizidine alkaloids from some Senecio species (Compositae or Asteraceae), and the diterpene ester from Croton tiglium L. and Euphorbia ingens E. Mey (Euphorbiaceae) were chosen as representatives of both groups. The possibilities and limitations of {sup 1}H and {sup 13}C nuclear magnetic resonance spectroscopy ({sup 1}H and {sup 13}C NMR) for the analysis of mixtures of carcinogenic pyrrolizidine alkaloids were compared with high performance liquid chromatography, and gas chromatography with high performance liquid chromatography, and gas chromatography was well as gas chromatography - mass spectrometry. Senecio vulgaris L., Senecio vernalis Waldst. and Kit. and Senecio jacobaea L. were investigated.

  12. Euphorbia heterophylla leaf extract mediated green synthesis of Ag/TiO2 nanocomposite and investigation of its excellent catalytic activity for reduction of variety of dyes in water.

    Science.gov (United States)

    Atarod, Monireh; Nasrollahzadeh, Mahmoud; Mohammad Sajadi, S

    2016-01-15

    This work reports a facile and green synthesis of Ag/TiO2 nanocomposite by extract of leaves of Euphorbia heterophylla without any stabilizer or surfactant. The green synthesized Ag/TiO2 nanocomposite was characterized by field emission scanning electron microscope (FESEM), energy-dispersive X-ray spectroscopy (EDS), fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction analysis (XRD) and UV-vis. The Ag/TiO2 nanocomposite was found to be effective catalyst for reduction of various dyes, such as 4-nitrophenol (4-NP), Methyl orange (MO), Congo red (CR) and Methylene blue (MB) in the presence of NaBH4 in water at room temperature. Catalysis reactions were monitored by employing UV-vis spectroscopy. Catalysis reactions followed pseudo-first order rate equation. The catalyst can be recovered and reused several times without significant loss of its catalytic activity. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. DEEP VEIN THROMBOSIS IN PATIENT WITH VON WILLEBRAND DISEASE

    Directory of Open Access Journals (Sweden)

    V. A. Elykomov

    2016-01-01

    Full Text Available Objective: to identify the possible factors of thrombogenic risk and ways of its prevention in patients with von Willebrand disease.Case description. Patient X., 42 years old, who suffers from von Willebrand disease type 3 with 5-years of age. Asked on reception to the traumatologist in the polyclinic of the Regional Hospital with pain in the left hip joint. Recommended planned operative treatment in the Altai Regional Clinical Hospital. Preoperative preparation included the infusion of concentrate of von Willebrand factor and coagulation factor VIII. Operation – cement total arthroplasty of the left hip joint. In the postoperative period analgesic treatment, elastic compression of the lower extremities, iron supplements, also conducted infusion of concentrate of von Willebrand factor and coagulation factor VIII for 20 days and thromboprophylactic with dabigatran. On the 3rd day after the operation the patient revealed deep vein thrombosis of the femoral segment (floating clot.Results. The patient was operated for emergency indications in the Department of endovascular surgery – installation of venous cava filter “Volan”. Dabigatran is cancelled, appointed clexane for 3 months. In our clinical example the patient lacked risk factors of pulmonary embolism as obesity, age, smoking, prolonged immobilization, estrogen therapy. Overdose of factor VIII were not observed – the level of factor did not exceed 135 % on transfusions. At the same time, the patient was found polymorphisms in the genes ITGA2, FGB, MTHFR, MTR – heterozygote, MTRR – mutant homozygote, which may indicate the genetic factors of thrombogenic risk. Also a significant risk factor was massive surgical intervention (total hip replacement. Despite preventive measures (elastic compression, thromboprophylactic dabigatran, early activation we cannot to avoid thrombotic complications.Conclusion. This article presents a case demonstrating a thrombotic complication in patients

  14. Effets de Panicum maximum Jacq. associé à Euphorbia heterophylla (L. Klotz. & Garcke sur la productivité des femelles durant le cycle de reproduction chez le cobaye (Cavia porcellus L.

    Directory of Open Access Journals (Sweden)

    N'G. D.V. Kouakou

    2015-01-01

    Full Text Available Effect of Panicum maximum Jacq. Associated with Euphorbia heterophylla (L. Klotz. & Garcke on Productivity of Females (Cavia porcellus L During the Reproductive Cycle. In Ivory Coast, Guinea pigs reared for meat (Cavia porcellus L. are mainly fed with Panicum maximum Jacq. The association of this forage with Euphorbia heterophylla (L. Klotz. & Garcke improves the organic matter digestibility of the mixed diet compared to P. maximum distributed alone in growing male guinea pigs. In order to determine the effect of this diet during gestation and lactation in female guinea pigs, three diets: P. maximum (PAN basic diet; P. maximum associated to E. heterophylla (PANEUPH and P. maximum associated to pellets for rabbit (PANGRAN, were distributed ad libitum to multiparous guinea pigs (604.9 ± 40.8 g. The daily ingestion during gestation and lactation were 59.8±11.2 and 53.2±8.5; 61.5±5.2 and 72.9±16.4; 83.1±12.9 and 111.3±13.9 g DM.d-1 respectively for PAN, PANEUPH and PANGRAN. Similarly, the rates of fecundity were 111.1±0.9; 188.9±0.6 and 244.4±0.5% respectively for PAN, PANEUPH and PANGRAN. The individual birth weight and weight gain during lactation of the piglets were 58.7±12.4, 75.6±16.2 and 102.5±12 g and 2.4±0.6; 4.1±0.9 and 6.5±1.2 g.d-1 respectively for PAN, PANEUPH, and PANGRAN. In conclusion, the association of P. maximum and E. heterophylla significantly improves ingestion, digestibility, fecundity, birth weight and weaning weight in guinea pigs in comparison to Panicum maximum used as a sole diet.

  15. Jakob von Uexküll : tuleb hakata taas koos oma planeediga elama / Jakob von Uexküll ; interv. Andris Feldmanis

    Index Scriptorium Estoniae

    Uexküll, Jakob von

    2007-01-01

    Jakob von Uexküll vastab küsimustele, mis puudutavad postkapitalismi, kapitalismi vajakajäämisi, praegust kapitalismi, postkapitalismi n.-ö. filosoofilist süsteemi, samuti kohtumist president Toomas Hendrik Ilvesega. J. von Uexküll esitles Eesti presidendile Maailma Tuleviku Nõukogu (World Future Council) projekti

  16. The effect of exercise on von Willebrand factor and ADAMTS-13 in individuals with type 1 and type 2B von Willebrand disease

    NARCIS (Netherlands)

    Stakiw, J.; Bowman, M.; Hegadorn, C.; Pruss, C.; Notley, C.; Groot, E.; Lenting, P. J.; Rapson, D.; Lillicrap, D.; James, P.

    Background: The effect of exercise on von Willebrand factor (VWF) and ADAMTS-13 levels in individuals with von Willebrand disease (VWD) has never been reported. Objectives: The aim was to quantify the effect of a standardized exercise protocol on individuals with type 1 and type 2B VWD.

  17. [Die baltischen Kapitulationen von 1710. Kontext - Wirkungen - Interpretationen. Hrsg. von Karsten Brüggemann, Mati Laur und Pärtel Piirimäe] / Maretn Seppel

    Index Scriptorium Estoniae

    Seppel, Marten, 1979-

    2015-01-01

    Arvustus: Die baltischen Kapitulationen von 1710. Kontext - Wirkungen - Interpretationen. Hrsg. von Karsten Brüggemann, Mati Laur und Pärtel Piirimäe. (Quellen und Studien zur baltischen Geschichte. Bd. 23). Köln [etc.] : Böhlau, 2014

  18. Rezension von: Gabriele Dietze: Weiße Frauen in Bewegung. Genealogien und Konkurrenzen von Race- und Genderpolitiken. Bielefeld: transcript Verlag 2013.

    Directory of Open Access Journals (Sweden)

    Philipp Dorestal

    2014-03-01

    Full Text Available Gabriele Dietze zeichnet das Verhältnis der Kategorien Race und Gender innerhalb der US-amerikanischen Geschichte von der Mitte des 19. Jahrhunderts bis zur Präsidentschaftswahl von Barack Obama nach. Dabei demonstriert sie anhand von zentralen Figuren der weißen Frauenbewegung deren ambivalente Positionen, die oftmals für progressive Inhalte wie das Eintreten für Frauenrechte stehen, gleichzeitig aber dann Anliegen von African Americans nicht artikulieren oder gar zum Schweigen bringen. Ebenso zeigt Dietze mithilfe von Texten einiger schwarzer Autor_innen sowie anhand berühmter Gerichtsprozesse, dass schwarze Emanzipation nicht notwendigerweise mit feministischen Positionen einhergehen musste, sondern sich vielmehr eine Konkurrenzsituation zwischen Race und Gender entspann.

  19. Up-to-date der Betreuung von Chorionkarzinompatientinnen - ein Fallbeispiel

    Directory of Open Access Journals (Sweden)

    Söhnchen N

    2010-01-01

    Full Text Available Das Chorionkarzinom tritt in Europa bei einer von 30.000 Schwangerschaften auf. Betroffen sind vor allem junge und ältere Mütter sowie Patientinnen mit einer positiven Anamnese für Trophoblasterkrankungen. Kardinalsymptome sind persistierende vaginale Blutungen nach der Geburt. Bei Diagnosestellung liegen häufig bereits pulmonale Metastasen vor. In der Behandlung spielt die Chirurgie nur eine untergeordnete Rolle. Der rasche und ununterbrochene Beginn einer Chemotherapie ist hingegen entscheidend. Oft reicht eine Monochemotherapie aus. Hochrisikopatienten werden hingegen mit einer Kombinationschemotherapie (EMA/CO behandelt. Das Ansprechen auf diese Therapie ist ausgesprochen gut. Wichtig sind die weiteren Kontrollen der Patientinnen mithilfe von biochemischen Markern und radiologischer Diagnostik. Kinder betroffener Frauen sollten ebenfalls kontrolliert werden, da es auch bei ihnen zu einer intrauterinen Metastasierung gekommen sein kann. Wir stellen das diagnostische und therapeutische Vorgehen anhand eines aktuellen Fallbeispiels aus unserer Klinik dar.

  20. Der Weg von einer produktionsintegrierten Instandhaltung zum erfolgreichen, outgesourcten Dienstleister

    Science.gov (United States)

    Luther, Friedrich

    Eine marktorientierte Unternehmensführung verlangt heute auch ein kritisches Überdenken der Dienstleistung Instandhaltung und deren Schnittstellen zu anderen Unternehmensbereichen. Die Instandhaltung als Dienstleistungsabteilung, welche oft zu Unrecht als nicht "produktiver“ Betriebsbereich angesehen wird, sieht sich deshalb vielen Fragen und Überprüfungen hinsichtlich ihrer Funktion und Effizienz ausgesetzt. In diesem Beitrag soll beispielhaft der Weg einer solchen Instandhaltung vom produktionsintegrierten Bereich in einem mittelständischen Maschinenbau-Unternehmen des Textilmaschinenbaus über den zentralen/dezentralen autonomen Unternehmensbereich zum Profit-Center und letztendlich die Entwicklung zum erfolgreichen externen Dienstleister, eingegliedert in die Piepenbrock Gruppe, dargestellt werden. Dieser Entwicklungsprozess überstreicht einen Zeitraum von etwa 60 Jahren, von 1950 bis heute. Die Betrachtung des gesamten Prozessablaufs, die dabei aufgetretenen Probleme und Hindernisse auf dem Weg zum externen Dienstleister werden analysiert und Aspekte der Zusammenarbeit mit den Betreibern aus Sicht der outgesourcten Instandhaltung aufgezeigt.