WorldWideScience

Sample records for volume iii prediction

  1. 76 FR 60511 - Amendment of Marine Safety Manual, Volume III

    Science.gov (United States)

    2011-09-29

    ... SECURITY Coast Guard Amendment of Marine Safety Manual, Volume III AGENCY: Coast Guard, DHS. ACTION: Notice... Offshore Units. The policy is currently found in Chapter 16 of the Marine Safety Manual, Volume III. The... Federal Register (73 FR 3316). Background and Purpose Chapter 16 of Volume III of the Marine Safety...

  2. Culture of Schools. Final Report. Volume III.

    Science.gov (United States)

    American Anthropological Association, Washington, DC.

    The third volume of this 4-volume report contains the last two speeches, on educational philosophy and the role of reason in society, from the Colloquium on the Culture of Schools held at the New School for Social Research (preceding speeches are in Vol. II, SP 003 901), reports on conferences on the culture of schools held in Pittsburgh and…

  3. Ways to Environmental Education, Volume III.

    Science.gov (United States)

    Allen, Rodney F., Ed.; And Others

    Ten environmental education booklets presented in this document are the third volume of the environmental series developed by community groups around the Tallahassee Junior Museum and its Pioneer Farm. The first three booklets present an overview of the museum and of the various education programs and activities offered for students at the museum…

  4. DART II documentation. Volume III. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-01

    The DART II is a remote, interactive, microprocessor-based data acquistion system suitable for use with air monitors. This volume of DART II documentation contains the following appendixes: adjustment and calibration procedures; mother board signature list; schematic diagrams; device specification sheets; ROM program listing; 6800 microprocessor instruction list, octal listing; and cable lists. (RWR)

  5. DART II documentation. Volume III. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    1979-05-23

    The DART II is a data acquisition system that can be used with air pollution monitoring equipment. This volume contains appendices that deal with the following topics: adjustment and calibration procedures (power supply adjustment procedure, ADC calibration procedure, analog multiplexer calibration procedure); mother board signature list; schematic diagrams; device specification sheets (microprocessor, asynchronous receiver/transmitter, analog-to-digital converter, arithmetic processing unit, 5-volt power supply, +- 15-volt power supply, 24-volt power supply, floppy disk formater/controller, random access static memory); ROM program listing; 6800 microprocessor instruction set, octal listing; and cable lists. (RR)

  6. Free radicals in biology. Volume III

    Energy Technology Data Exchange (ETDEWEB)

    Pryor, W.A. (ed.)

    1977-01-01

    This volume covers topics ranging from radiation chemistry to biochemistry, biology, and medicine. This volume attempts to bridge the gap between chemical investigations and the medical applications and implications of free radical reactions. Chapter 1 provides a general introduction to the technique of radiation chemistry, the thermodynamics and kinetic factors that need be considered, the use of pulse radiolysis and flow techniques, and the application of these methods to free radicals of biological interest. Chapter 3 discusses the mechanisms of carbon tetrachloride toxicity. Chapter 4 reviews the morphological, histochemical, biochemical, and chemical nature of lipofuscin pigments. This chapter brings together the evidence that lipofuscin pigments arise from free radical pathology and that the formation of these pigments proves the presence of lipid peroxidation in vivo. Chapter 5 reviews the evidence for production of free (i.e., scavengeable) radicals from the reactions of selected enzymes with their substrates. Chapter 6 discusses one of the systems in which free radical damage is clearly important in vivo, both for man and animal, the damage caused to skin by sunlight. The evidence that free radical reactions can contribute to carcinogenesis dates from the earliest observations that ionizing radiation often produces higher incidences of tumors. A current working hypothesis is that chemical toxins cause damage to DNA and that the repair of this damge may incorporate viral genetic information into the host cell's chromosomes, producing cell transformation and cancer. The mechanism whereby chemical carcinogens become bound to DNA to produce point defects is discussed in Chapter 7.

  7. Technology transfer package on seismic base isolation - Volume III

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-02-14

    This Technology Transfer Package provides some detailed information for the U.S. Department of Energy (DOE) and its contractors about seismic base isolation. Intended users of this three-volume package are DOE Design and Safety Engineers as well as DOE Facility Managers who are responsible for reducing the effects of natural phenomena hazards (NPH), specifically earthquakes, on their facilities. The package was developed as part of DOE's efforts to study and implement techniques for protecting lives and property from the effects of natural phenomena and to support the International Decade for Natural Disaster Reduction. Volume III contains supporting materials not included in Volumes I and II.

  8. Prediction of Railway Passenger Traffic Volume

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The current situation of the railway passenger traffic (RPT) andthe traffic marketing is analyzed. The grey model theory is adopted to establish a prediction model for the railway passenger traffic volume (RPTV). The RPTV from 2001 to 2005 is predicted with the proposed model, and a few suggestions are put forward.

  9. Breckinridge Project, initial effort. Report III, Volume 2. Specifications

    Energy Technology Data Exchange (ETDEWEB)

    None

    1982-01-01

    Report III, Volume 2 contains those specifications numbered K through Y, as follows: Specifications for Compressors (K); Specifications for Piping (L); Specifications for Structures (M); Specifications for Insulation (N); Specifications for Electrical (P); Specifications for Concrete (Q); Specifications for Civil (S); Specifications for Welding (W); Specifications for Painting (X); and Specifications for Special (Y). The standard specifications of Bechtel Petroleum Incorporated have been amended as necessary to reflect the specific requirements of the Breckinridge Project and the more stringent specifications of Ashland Synthetic Fuels, Inc. These standard specifications are available for the Initial Effort (Phase Zero) work performed by all contractors and subcontractors.

  10. Minerals Yearbook, volume III, Area Reports—International

    Science.gov (United States)

    ,

    2017-01-01

    The U.S. Geological Survey (USGS) Minerals Yearbook discusses the performance of the worldwide minerals and materials industries and provides background information to assist in interpreting that performance. Content of the individual Minerals Yearbook volumes follows:Volume I, Metals and Minerals, contains chapters about virtually all metallic and industrial mineral commodities important to the U.S. economy. Chapters on survey methods, summary statistics for domestic nonfuel minerals, and trends in mining and quarrying in the metals and industrial mineral industries in the United States are also included.Volume II, Area Reports: Domestic, contains a chapter on the mineral industry of each of the 50 States and Puerto Rico and the Administered Islands. This volume also has chapters on survey methods and summary statistics of domestic nonfuel minerals.Volume III, Area Reports: International, is published as four separate reports. These regional reports contain the latest available minerals data on more than 180 foreign countries and discuss the importance of minerals to the economies of these nations and the United States. Each report begins with an overview of the region’s mineral industries during the year. It continues with individual country chapters that examine the mining, refining, processing, and use of minerals in each country of the region and how each country’s mineral industry relates to U.S. industry. Most chapters include production tables and industry structure tables, information about Government policies and programs that affect the country’s mineral industry, and an outlook section.The USGS continually strives to improve the value of its publications to users. Constructive comments and suggestions by readers of the Minerals Yearbook are welcomed.

  11. Thermodynamic data for predicting concentrations of Pu(III), Am(III), and Cm(III) in geologic environments

    Energy Technology Data Exchange (ETDEWEB)

    Rai, Dhanpat; Rao, Linfeng; Weger, H.T.; Felmy, A.R. [Pacific Northwest National Laboratory, WA (United States); Choppin, G.R. [Florida State University, Florida (United States); Yui, Mikazu [Japan Nuclear Cycle Development Inst., Tokai Works, Tokai, Ibaraki (Japan)

    1999-01-01

    This report provides thermodynamic data for predicting concentrations of Pu(III), Am(III), and Cm(III) in geologic environments, and contributes to an integration of the JNC chemical thermodynamic database, JNC-TDB (previously PNC-TDB), for the performance analysis of geological isolation system for high-level radioactive wastes. Thermodynamic data for the formation of complexes or compounds with hydroxide, chloride, fluoride, carbonate, nitrate, sulfate and phosphate are discussed in this report. Where data for specific actinide(III) species are lacking, the data were selected based on chemical analogy to other trivalent actinides. In this study, the Pitzer ion-interaction model is mainly used to extrapolate thermodynamic constants to zero ionic strength at 25degC. (author)

  12. Predicting Efficient Antenna Ligands for Tb(III) Emission

    Energy Technology Data Exchange (ETDEWEB)

    Samuel, Amanda P.S.; Xu, Jide; Raymond, Kenneth

    2008-10-06

    A series of highly luminescent Tb(III) complexes of para-substituted 2-hydroxyisophthalamide ligands (5LI-IAM-X) has been prepared (X = H, CH{sub 3}, (C=O)NHCH{sub 3}, SO{sub 3}{sup -}, NO{sub 2}, OCH{sub 3}, F, Cl, Br) to probe the effect of substituting the isophthalamide ring on ligand and Tb(III) emission in order to establish a method for predicting the effects of chromophore modification on Tb(III) luminescence. The energies of the ligand singlet and triplet excited states are found to increase linearly with the {pi}-withdrawing ability of the substituent. The experimental results are supported by time-dependent density functional theory (TD-DFT) calculations performed on model systems, which predict ligand singlet and triplet energies within {approx}5% of the experimental values. The quantum yield ({Phi}) values of the Tb(III) complex increases with the triplet energy of the ligand, which is in part due to the decreased non-radiative deactivation caused by thermal repopulation of the triplet. Together, the experimental and theoretical results serve as a predictive tool that can be used to guide the synthesis of ligands used to sensitize lanthanide luminescence.

  13. Industrial Fuel Gas Demonstration Plant Program. Volume III. Demonstration plant environmental analysis (Deliverable No. 27)

    Energy Technology Data Exchange (ETDEWEB)

    1979-08-01

    An Environmental Report on the Memphis Light, Gas and Water Division Industrial Fuel Demonstration Plant was prepared for submission to the US Department of Energy under Contract ET-77-C-01-2582. This document is Volume III of a three-volume Environmental Report. Volume I consists of the Summary, Introduction and the Description of the Proposed Action. Volume II consists of the Description of the Existing Environment. Volume III contains the Environmental Impacts of the Proposed Action, Mitigating Measures and Alternatives to the Proposed Action.

  14. Industrial Maintenance, Volume III. Post Secondary Curriculum Guide.

    Science.gov (United States)

    Butler, Raymond H.; And Others

    This volume is the fourth of four volumes that comprise a curriculum guide for a postsecondary industrial maintenance program. It contains three sections and appendixes. Section 4 provides suggested methods of structuring the curriculum. Suggested ways of recording and documenting student progress are presented in section 5. Section 6 contains…

  15. National Utility Financial Statement model (NUFS). Volume III of III: software description. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-29

    This volume contains a description of the software comprising the National Utility Financial Statement Model (NUFS). This is the third of three volumes describing NUFS provided by ICF Incorporated under contract DEAC-01-79EI-10579. The three volumes are entitled: model overview and description, user's guide, and software guide.

  16. Higher Education: Handbook of Theory and Research. Volumes III [and] IV.

    Science.gov (United States)

    Smart, John C., Ed.

    Two volumes of a handbook on theory and research in higher education are presented. The 11 papers included in Volume III are as follows: "Qualitative Research Methods in Higher Education" (R. Crowson); "Bricks and Mortar: Architecture and the Study of Higher Education" (J. Thelin and J. Yankovich); "Enrollment Demand Models and Their Policy Uses…

  17. An Evaluation of the Nutrition Services for the Elderly. Volume III. Descriptive Report.

    Science.gov (United States)

    Kirschner Associates, Inc., Albuquerque, NM.

    This document is part of a five-volume nationwide study of Nutrition Services operations and elderly citizens participating in congregate dining and home delivery services authorized by Title III-C of the Older Americans' Act. A descriptive report is contained in this volume, which presents non-selective and preliminary analysis of the data base…

  18. Workpapers in English as a Second Language, [Volume III].

    Science.gov (United States)

    Bracy, Maryruth, Ed.

    This volume contains the 1969 working papers on subjects related to teaching English as a second language (TESL) and abstracts of Masters Theses completed by students studying TESL. Several articles discuss teaching and learning a second language and practical considerations in second language learning such as reading and writing skills, the use…

  19. Council on Anthropology and Education Newsletter. Volume III, Number 1.

    Science.gov (United States)

    Singleton, John Ed.

    General information on format, included, materials, broad concerns, objectives, and availability of the newsletter are described in Volume I, ED 048 049. This issue focuses on ethnology, offering two papers presented at the American Anthropological Association symposiums. The lead paper presents a psycho-cultural developmental approach to the…

  20. Albanian: Basic Course. Volume III, Lessons 27-36.

    Science.gov (United States)

    Defense Language Inst., Monterey, CA.

    This third of ten volumes of audiolingual classroom instruction in Albanian for adult students treats Albanian grammar, syntax, and usage in a series of exercises consisting of grammar perception drills, grammar analysis, translation exercises, readings, question-and-answer exercises, and dialogues illustrating specific grammatical features. A…

  1. Prediction of Overpressure from Finite Volume Explosions

    Directory of Open Access Journals (Sweden)

    K. Ramamurthi

    1995-01-01

    Full Text Available Tri-nitro toluene (TNT equivalence is not a good criterion for evaluating the practically encounted nonideal blast waves during ignition and in explosion-safety problems. A theoretical model which shows the trends related to the effects of source volume and energy time release on blast wave strength is discussed. A slower energy release and a larger source volume are shown to be necessary to reduce the blast effects.

  2. An Independent Scientific Assessment of Well Stimulation in California Volume III

    Energy Technology Data Exchange (ETDEWEB)

    Long, Jane C.S. [California Council on Science and Technology, Sacramento, CA (United States); Feinstein, Laura C. [California Council on Science and Technology, Sacramento, CA (United States); Birkholzer, Jens [California Council on Science and Technology, Sacramento, CA (United States); Foxall, William [California Council on Science and Technology, Sacramento, CA (United States); Houseworth, James [California Council on Science and Technology, Sacramento, CA (United States); Jordan, Preston [California Council on Science and Technology, Sacramento, CA (United States); Lindsey, Nathaniel [California Council on Science and Technology, Sacramento, CA (United States); Maddalena, Randy [California Council on Science and Technology, Sacramento, CA (United States); McKone, Thomas [California Council on Science and Technology, Sacramento, CA (United States); Stringfellow, William [California Council on Science and Technology, Sacramento, CA (United States); Ulrich, Craig [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Heberger, Matthew [Pacific Inst., Oakland, CA (United States); Shonkoff, Seth [PSE Healthy Energy, Berkeley, CA (United States); Brandt, Adam [Stanford Univ., CA (United States); Ferrar, Kyle [The FracTracker Alliance, Oakland, CA (United States); Gautier, Donald [DonGautier LLC., Palo Alto, CA (United States); Phillips, Scott [California State Univ. Stanislaus, Turlock, CA (United States); Greenfield, Ben [Univ. of California, Berkeley, CA (United States); Jerrett, Michael L.B. [Univ. of California, Los Angeles, CA (United States)

    2015-07-01

    This study is issued in three volumes. Volume I, issued in January 2015, describes how well stimulation technologies work, how and where operators deploy these technologies for oil and gas production in California, and where they might enable production in the future. Volume II, issued in July 2015, discusses how well stimulation could affect water, atmosphere, seismic activity, wildlife and vegetation, and human health. Volume II reviews available data, and identifies knowledge gaps and alternative practices that could avoid or mitigate these possible impacts. Volume III, this volume, presents case studies that assess environmental issues and qualitative risks for specific geographic regions. The Summary Report summarizes key findings, conclusions and recommendations of all three volumes.

  3. Spatial Economics Model Predicting Transport Volume

    Directory of Open Access Journals (Sweden)

    Lu Bo

    2016-10-01

    Full Text Available It is extremely important to predict the logistics requirements in a scientific and rational way. However, in recent years, the improvement effect on the prediction method is not very significant and the traditional statistical prediction method has the defects of low precision and poor interpretation of the prediction model, which cannot only guarantee the generalization ability of the prediction model theoretically, but also cannot explain the models effectively. Therefore, in combination with the theories of the spatial economics, industrial economics, and neo-classical economics, taking city of Zhuanghe as the research object, the study identifies the leading industry that can produce a large number of cargoes, and further predicts the static logistics generation of the Zhuanghe and hinterlands. By integrating various factors that can affect the regional logistics requirements, this study established a logistics requirements potential model from the aspect of spatial economic principles, and expanded the way of logistics requirements prediction from the single statistical principles to an new area of special and regional economics.

  4. Field Operations and Enforcement Manual for Air Pollution Control. Volume III: Inspection Procedures for Specific Industries.

    Science.gov (United States)

    Weisburd, Melvin I.

    The Field Operations and Enforcement Manual for Air Pollution Control, Volume III, explains in detail the following: inspection procedures for specific sources, kraft pulp mills, animal rendering, steel mill furnaces, coking operations, petroleum refineries, chemical plants, non-ferrous smelting and refining, foundries, cement plants, aluminum…

  5. Field Operations and Enforcement Manual for Air Pollution Control. Volume III: Inspection Procedures for Specific Industries.

    Science.gov (United States)

    Weisburd, Melvin I.

    The Field Operations and Enforcement Manual for Air Pollution Control, Volume III, explains in detail the following: inspection procedures for specific sources, kraft pulp mills, animal rendering, steel mill furnaces, coking operations, petroleum refineries, chemical plants, non-ferrous smelting and refining, foundries, cement plants, aluminum…

  6. Technical Reports (Part I). End of Project Report, 1968-1971, Volume III.

    Science.gov (United States)

    Western Nevada Regional Education Center, Lovelock.

    The pamphlets included in this volume are technical reports prepared as outgrowths of the Student Information Systems of the Western Nevada Regional Education Center (WN-REC) funded by a Title III (Elementary and Secondary Education Act) grant. These reports describe methods of interpreting the printouts from the Student Information System;…

  7. Neural network predicts carrot volume with only three images

    Science.gov (United States)

    Hahn, Federico; Sanchez, Sergio

    1998-09-01

    A mechanism turned a vision camera around a fixed carrot taking 100 images of it. A 3D reconstruction finite element algorithm reproduced the volume using finite area triangles and morphological operations to optimize memory utilization. Volume from several carrots were calculated and correlated against real volume achieving a 98% success rate. Three images 120 degrees apart were acquired and the main features extracted. A neural network system was trained using the features, increasing the measuring speed and obtaining together with a regression algorithm an accuracy of 95% in predicting the real volume.

  8. Predictions of urban volumes in single time series

    NARCIS (Netherlands)

    Thomas, Tom; Weijermars, Wendy; Berkum, van Eric

    2010-01-01

    Congestion is increasing in many urban areas. This has led to a growing awareness of the importance of accurate traffic-flow predictions. In this paper, we introduce a prediction scheme that is based on an extensive study of volume patterns that were collected at about 20 urban intersections in the

  9. Condylar volume and condylar area in class I, class II and class III young adult subjects

    Directory of Open Access Journals (Sweden)

    Saccucci Matteo

    2012-12-01

    Full Text Available Abstract Aim Aim of this study was to compare the volume and the shape of mandibular condyles in a Caucasian young adult population, with different skeletal pattern. Material and methods 200 Caucasian patients (15–30 years old, 95 male and 105 females were classified in three groups on the base of ANB angle: skeletal class I (65 patients, skeletal class II (70 patients and skeletal class III (65 patients. Left and right TMJs of each subject were evaluated independently with CBCT (Iluma. TMJ evaluation included: condylar volume; condylar area; morphological index (MI. Condylar volumes were calculated by using the Mimics software. The condylar volume, the area and the morphological index (MI were compared among the three groups, by using non-parametric tests. Results The Kruskal-Wallis test and the Mann Whitney test revealed that: no significant difference was observed in the whole sample between the right and the left condylar volume; subjects in skeletal class III showed a significantly higher condylar volume, respect to class I and class II subjects (p 3 in males and 663.5 ± 81.3 mm3 in females; p 2 in males and 389.76 ± 61.15 mm2 in females; p  Conclusion Skeletal class appeared to be associated to the mandibular condylar volume and to the mandibular condylar area in the Caucasian orthodontic population.

  10. Sound transmission through ducts and aircraft noise prediction, volume 1

    Science.gov (United States)

    Schauer, J. J.; Datko, J. T.; Guyton, R. W.

    1982-01-01

    Aircraft engine acoustical lining impedance models, ray acoustics, hydrodynamic modes, and transient analysis of sound propagation in variable area duct studies were applied to aircraft noise prediction. The effects of several duct lining configurations in a TF33 P5 and a CFM56 engined KC-135B aircraft were predicted. The prediction was based on a model corrected to fit flight noise data and modified by including theoretical duct noise attenuation predictions. The transient solution of variable area ducts permitted the prediction of sound propgation in bullet nose inlets for no low and was moderately successful when a potential flow was included with low Mach numbers. Volume 1 contains the technical report and analysis. Volume 2 contains the user's manuals and listings of the computer codes developed.

  11. Occupational Survey Report. Volume III. Programming Specialty, AFS 511X1.

    Science.gov (United States)

    1980-05-01

    ROGRAMMING 1SPECIALTY _ ".T\\ I , , ~AFPT 90-511-413 q ’VOLUME III OF III ON -Y 1980’ ’ q -ppT edfor public releaw; is: OCCUPATIONAL ANALYSIS PROGRAM ,"’ USAF...i I..... i l HI I . .. I Ij. ASSISTANT PROGRAMMING NCOICs (GRP308) PERCENT MEMBERS RF,-.N i:\\I’IVF ’ASKS PERFORMING L BEl k k ,,it’FR PROGRkM.S 96...EAVE OR LIBERfY 79 SilON,,, K NCOM ING PERSONNEl. 79 ODIF + UPDATE FXISI’ING COMPUTER PROGRAMS 75 REVIEW ,RA. SPECIFICATIONS 75 PREPARE PFIAl IEi) FLOW

  12. The biowaiver extension for BCS class III drugs: the effect of dissolution rate on the bioequivalence of BCS class III immediate-release drugs predicted by computer simulation.

    Science.gov (United States)

    Tsume, Yasuhiro; Amidon, Gordon L

    2010-08-02

    The Biopharmaceutical Classification System (BCS) guidance issued by the FDA allows waivers for in vivo bioavailability and bioequivalence studies for immediate-release (IR) solid oral dosage forms only for BCS class I drugs. However, a number of drugs within BCS class III have been proposed to be eligible for biowaivers. The World Health Organization (WHO) has shortened the requisite dissolution time of BCS class III drugs on their Essential Medicine List (EML) from 30 to 15 min for extended biowaivers; however, the impact of the shorter dissolution time on AUC(0-inf) and C(max) is unknown. The objectives of this investigation were to assess the ability of gastrointestinal simulation software to predict the oral absorption of the BCS class I drugs propranolol and metoprolol and the BCS class III drugs cimetidine, atenolol, and amoxicillin, and to perform in silico bioequivalence studies to assess the feasibility of extending biowaivers to BCS class III drugs. The drug absorption from the gastrointestinal tract was predicted using physicochemical and pharmacokinetic properties of test drugs provided by GastroPlus (version 6.0). Virtual trials with a 200 mL dose volume at different drug release rates (T(85%) = 15 to 180 min) were performed to predict the oral absorption (C(max) and AUC(0-inf)) of the above drugs. Both BCS class I drugs satisfied bioequivalence with regard to the release rates up to 120 min. The results with BCS class III drugs demonstrated bioequivalence using the prolonged release rate, T(85%) = 45 or 60 min, indicating that the dissolution standard for bioequivalence is dependent on the intestinal membrane permeability and permeability profile throughout the gastrointestinal tract. The results of GastroPlus simulations indicate that the dissolution rate of BCS class III drugs could be prolonged to the point where dissolution, rather than permeability, would control the overall absorption. For BCS class III drugs with intestinal absorption patterns

  13. Hanford spent nuclear fuel project recommended path forward, volume III: Alternatives and path forward evaluation supporting documentation

    Energy Technology Data Exchange (ETDEWEB)

    Fulton, J.C.

    1994-10-01

    Volume I of the Hanford Spent Nuclear Fuel Project - Recommended Path Forward constitutes an aggressive series of projects to construct and operate systems and facilities to safely retrieve, package, transport, process, and store K Basins fuel and sludge. Volume II provided a comparative evaluation of four Alternatives for the Path Forward and an evaluation for the Recommended Path Forward. Although Volume II contained extensive appendices, six supporting documents have been compiled in Volume III to provide additional background for Volume II.

  14. Condylar volume and condylar area in class I, class II and class III young adult subjects

    OpenAIRE

    Saccucci Matteo; D’Attilio Michele; Rodolfino Daria; Festa Felice; Polimeni Antonella; Tecco Simona

    2012-01-01

    Abstract Aim Aim of this study was to compare the volume and the shape of mandibular condyles in a Caucasian young adult population, with different skeletal pattern. Material and methods 200 Caucasian patients (15–30 years old, 95 male and 105 females) were classified in three groups on the base of ANB angle: skeletal class I (65 patients), skeletal class II (70 patients) and skeletal class III (65 patients). Left and right TMJs of each subject were evaluated independently with CBCT (Iluma). ...

  15. Impact of Trading Volume on Prediction of Stock Market Development

    Directory of Open Access Journals (Sweden)

    Rudolf Plachý

    2014-01-01

    Full Text Available The paper focuses on the influence of trading volume on quality of prediction of stock market development. The main objective of this article is to assess the influence of stock trading volume level on quality of prediction with use of technical analysis. The research was applied on stocks included in the S & P 500 index. Based on average daily trading volume, three aggregate indexes were constructed. The dynamics of index return volatility was modeled by GARCH-class models. GARCH(1,1, GJR and EGARCH models were estimated for each time series. The in-sample evidence indicated that the return volatility of the indexes can be characterized by significant persistence and asymmetric effects. The best estimate of each model was produced for the index of stocks with the highest average trading volume.However the result could differ based on the observed period, the volatility structure of the examined data supports the idea that influential investors respond to various shocks in the market primarily by closing or opening their largest position.The importance of the level of trading volume for the prediction of financial time series development was shown in the paper. This finding could help generate such volatility structure of time series which would allow to explain development of the time series by various models with better results.

  16. Computational Methods for Protein Structure Prediction and Modeling Volume 2: Structure Prediction

    CERN Document Server

    Xu, Ying; Liang, Jie

    2007-01-01

    Volume 2 of this two-volume sequence focuses on protein structure prediction and includes protein threading, De novo methods, applications to membrane proteins and protein complexes, structure-based drug design, as well as structure prediction as a systems problem. A series of appendices review the biological and chemical basics related to protein structure, computer science for structural informatics, and prerequisite mathematics and statistics.

  17. Energy extension service pilot program evaluation report: the first year. Volume III: supplementary reports

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-09-01

    The appendices presented in this volume support and supplement Volume I of the Energy Extension Service Pilot Program Evaluation Report: The First Year. The appendices contain back-up data and detailed information on energy savings estimation and other analytic procedures. This volume also describes the data sources used for the evaluation. Appendix I presents the Btu estimation procedures used to calculate state-by-state energy savings. Appendix II contains details of the data sources used for the evaluation. Appendix III presents program activity data, budget, and cost per client analyses. Appendix IV, the Multivariate Analysis of EES Survey Data, provides the basis for the Integrating Statistical Analyses. Appendix V describes the rationale and exclusion rules for outlying data points. The final appendix presents program-by-program fuel costs and self-reported savings and investment.

  18. Disorganized Attachment in Infancy Predicts Greater Amygdala Volume in Adulthood

    Science.gov (United States)

    Lyons-Ruth, K.; Pechtel, P.; Yoon, S.A.; Anderson, C.M.; Teicher, M.H.

    2016-01-01

    Early life stress in rodents is associated with increased amygdala volume in adulthood. In humans, the amygdala develops rapidly during the first two years of life. Thus, disturbed care during this period may be particularly important to amygdala development. In the context of a 30-year longitudinal study of impoverished, highly stressed families, we assessed whether disorganization of the attachment relationship in infancy was related to amygdala volume in adulthood. Amygdala volumes were assessed among 18 low-income young adults (8M/10F, 29.33±0.49 years) first observed in infancy (8.5±5.6 months) and followed longitudinally to age 29. In infancy (18.58±1.02 mos), both disorganized infant attachment behavior and disrupted maternal communication were assessed in the standard Strange Situation Procedure (SSP). Increased left amygdala volume in adulthood was associated with both maternal and infant components of disorganized attachment interactions at 18 months of age (overall r = .679, p < .004). Later stressors, including childhood maltreatment and attachment disturbance in adolescence, were not significantly related to left amygdala volume. Left amygdala volume was further associated with dissociation and limbic irritability in adulthood. Finally, left amygdala volume mediated the prediction from attachment disturbance in infancy to limbic irritability in adulthood. Results point to the likely importance of quality of early care for amygdala development in human children as well as in rodents. The long-term prediction found here suggests that the first two years of life may be an early sensitive period for amygdala development during which clinical intervention could have particularly important consequences for later child outcomes. PMID:27060720

  19. Noninvasively derived stroke volume variation by finger volume clamping can reliably predict fluid responsiveness

    NARCIS (Netherlands)

    Vos, Jaap Jan; Poterman, Marieke; Struys, Michel; Scheeren, Thomas; Kalmar, A.F.

    2013-01-01

    Background and Goal of Study:  Dynamic preload variables derived from the arterial pressure waveform have been shown to accurately predict fluid responsiveness in mechanically ventilated patients. One of these variables, stroke volume variation (SVV), can also be obtained noninvasively by the finger

  20. World Energy Data System (WENDS). Volume III. Country data, LY-PO

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-06-01

    The World Energy Data System contains organized data on those countries and international organizations that may have critical impact on the world energy scene. Included in this volume, Vol. III, are Libya, Luxembourg, Malaysia, Mexico, Netherlands, New Zealand, Niger, Nigeria, Norway, Pakistan, Peru, Philippines, Poland, and Portugal. The following topics are covered for most of the countries: economic, demographic, and educational profiles; energy policy; indigenous energy resources and uses; forecasts, demand, exports, imports of energy supplies; environmental considerations of energy supplies; power production facilities; energy industries; commercial applications of energy; research and development activities of energy; and international activities.

  1. Regional hippocampal volumes and development predict learning and memory.

    Science.gov (United States)

    Tamnes, Christian K; Walhovd, Kristine B; Engvig, Andreas; Grydeland, Håkon; Krogsrud, Stine K; Østby, Ylva; Holland, Dominic; Dale, Anders M; Fjell, Anders M

    2014-01-01

    The hippocampus is an anatomically and functionally heterogeneous structure, but longitudinal studies of its regional development are scarce and it is not known whether protracted maturation of the hippocampus in adolescence is related to memory development. First, we investigated hippocampal subfield development using 170 longitudinally acquired brain magnetic resonance imaging scans from 85 participants aged 8-21 years. Hippocampal subfield volumes were estimated by the use of automated segmentation of 7 subfields, including the cornu ammonis (CA) sectors and the dentate gyrus (DG), while longitudinal subfield volumetric change was quantified using a nonlinear registration procedure. Second, associations between subfield volumes and change and verbal learning/memory across multiple retention intervals (5 min, 30 min and 1 week) were tested. It was hypothesized that short and intermediate memory would be more closely related to CA2-3/CA4-DG and extended, remote memory to CA1. Change rates were significantly different across hippocampal subfields, but nearly all subfields showed significant volume decreases over time throughout adolescence. Several subfield volumes were larger in the right hemisphere and in males, while for change rates there were no hemisphere or sex differences. Partly in support of the hypotheses, greater volume of CA1 and CA2-3 was related to recall and retention after an extended delay, while longitudinal reduction of CA2-3 and CA4-DG was related to learning. This suggests continued regional development of the hippocampus across adolescence and that volume and volume change in specific subfields differentially predict verbal learning and memory over different retention intervals, but future high-resolution studies are called for.

  2. Incremental Criterion Validity of the WJ-III COG Clinical Clusters: Marginal Predictive Effects beyond the General Factor

    Science.gov (United States)

    McGill, Ryan J.

    2015-01-01

    The current study examined the incremental validity of the clinical clusters from the Woodcock-Johnson III Tests of Cognitive Abilities (WJ-III COG) for predicting scores on the Woodcock-Johnson III Tests of Achievement (WJ-III ACH). All participants were children and adolescents (N = 4,722) drawn from the nationally representative WJ-III…

  3. Improvements in lake volume predictions using Landsat data

    Science.gov (United States)

    Gervin, J. C.; Shih, S. F.

    1981-01-01

    A cumulative error in the water balance budget for Lake Okeechobee produces a one million acre-foot discrepancy in the predicted water volume over a 4-year period. The major source of error appears to be complex shoreline marshes that comprise 20 percent of the lake surface. The water balance budget model presently treats these marshes as open water. Using Landsat data, the vegetation in the lake's littoral zone was classified multispectrally to provide a data base for determining water budget information. First, the acreage of a given plant species in the littoral zone was obtained with satellite data. Second, the surface area occupied by plants (which therefore could not be considered open water) was used to adjust the vegetation acreage giving an effective water surface. Based on this information, more detailed representations of evapotranspiration and total water surface (and hence total lake volume) could be provided to the water balance budget computation.

  4. Minerals Yearbook, volume III, Area Reports—International—Latin America and Canada

    Science.gov (United States)

    ,

    2017-01-01

    The U.S. Geological Survey (USGS) Minerals Yearbook discusses the performance of the worldwide minerals and materials industries and provides background information to assist in interpreting that performance. Content of the individual Minerals Yearbook volumes follows:Volume I, Metals and Minerals, contains chapters about virtually all metallic and industrial mineral commodities important to the U.S. economy. Chapters on survey methods, summary statistics for domestic nonfuel minerals, and trends in mining and quarrying in the metals and industrial mineral industries in the United States are also included.Volume II, Area Reports: Domestic, contains a chapter on the mineral industry of each of the 50 States and Puerto Rico and the Administered Islands. This volume also has chapters on survey methods and summary statistics of domestic nonfuel minerals.Volume III, Area Reports: International, is published as four separate reports. These regional reports contain the latest available minerals data on more than 180 foreign countries and discuss the importance of minerals to the economies of these nations and the United States. Each report begins with an overview of the region’s mineral industries during the year. It continues with individual country chapters that examine the mining, refining, processing, and use of minerals in each country of the region and how each country’s mineral industry relates to U.S. industry. Most chapters include production tables and industry structure tables, information about Government policies and programs that affect the country’s mineral industry, and an outlook section.The USGS continually strives to improve the value of its publications to users. Constructive comments and suggestions by readers of the Minerals Yearbook are welcomed.

  5. Minerals Yearbook, volume III, Area Reports—International—Europe and Central Eurasia

    Science.gov (United States)

    Geological Survey, U.S.

    2017-01-01

    The U.S. Geological Survey (USGS) Minerals Yearbook discusses the performance of the worldwide minerals and materials industries and provides background information to assist in interpreting that performance. Content of the individual Minerals Yearbook volumes follows:Volume I, Metals and Minerals, contains chapters about virtually all metallic and industrial mineral commodities important to the U.S. economy. Chapters on survey methods, summary statistics for domestic nonfuel minerals, and trends in mining and quarrying in the metals and industrial mineral industries in the United States are also included.Volume II, Area Reports: Domestic, contains a chapter on the mineral industry of each of the 50 States and Puerto Rico and the Administered Islands. This volume also has chapters on survey methods and summary statistics of domestic nonfuel minerals.Volume III, Area Reports: International, is published as four separate reports. These regional reports contain the latest available minerals data on more than 180 foreign countries and discuss the importance of minerals to the economies of these nations and the United States. Each report begins with an overview of the region’s mineral industries during the year. It continues with individual country chapters that examine the mining, refining, processing, and use of minerals in each country of the region and how each country’s mineral industry relates to U.S. industry. Most chapters include production tables and industry structure tables, information about Government policies and programs that affect the country’s mineral industry, and an outlook section.The USGS continually strives to improve the value of its publications to users. Constructive comments and suggestions by readers of the Minerals Yearbook are welcomed.

  6. Minerals Yearbook, volume III, Area Reports—International—Africa and the Middle East

    Science.gov (United States)

    ,

    2017-01-01

    The U.S. Geological Survey (USGS) Minerals Yearbook discusses the performance of the worldwide minerals and materials industries and provides background information to assist in interpreting that performance. Content of the individual Minerals Yearbook volumes follows:Volume I, Metals and Minerals, contains chapters about virtually all metallic and industrial mineral commodities important to the U.S. economy. Chapters on survey methods, summary statistics for domestic nonfuel minerals, and trends in mining and quarrying in the metals and industrial mineral industries in the United States are also included.Volume II, Area Reports: Domestic, contains a chapter on the mineral industry of each of the 50 States and Puerto Rico and the Administered Islands. This volume also has chapters on survey methods and summary statistics of domestic nonfuel minerals.Volume III, Area Reports: International, is published as four separate reports. These regional reports contain the latest available minerals data on more than 180 foreign countries and discuss the importance of minerals to the economies of these nations and the United States. Each report begins with an overview of the region’s mineral industries during the year. It continues with individual country chapters that examine the mining, refining, processing, and use of minerals in each country of the region and how each country’s mineral industry relates to U.S. industry. Most chapters include production tables and industry structure tables, information about Government policies and programs that affect the country’s mineral industry, and an outlook section.The USGS continually strives to improve the value of its publications to users. Constructive comments and suggestions by readers of the Minerals Yearbook are welcomed.

  7. A Validated Prediction Model for Overall Survival From Stage III Non-Small Cell Lung Cancer: Toward Survival Prediction for Individual Patients

    Energy Technology Data Exchange (ETDEWEB)

    Oberije, Cary, E-mail: cary.oberije@maastro.nl [Radiation Oncology, Research Institute GROW of Oncology, Maastricht University Medical Center, Maastricht (Netherlands); De Ruysscher, Dirk [Radiation Oncology, Research Institute GROW of Oncology, Maastricht University Medical Center, Maastricht (Netherlands); Universitaire Ziekenhuizen Leuven, KU Leuven (Belgium); Houben, Ruud [Radiation Oncology, Research Institute GROW of Oncology, Maastricht University Medical Center, Maastricht (Netherlands); Heuvel, Michel van de; Uyterlinde, Wilma [Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam (Netherlands); Deasy, Joseph O. [Memorial Sloan Kettering Cancer Center, New York (United States); Belderbos, Jose [Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam (Netherlands); Dingemans, Anne-Marie C. [Department of Pulmonology, University Hospital Maastricht, Research Institute GROW of Oncology, Maastricht (Netherlands); Rimner, Andreas; Din, Shaun [Memorial Sloan Kettering Cancer Center, New York (United States); Lambin, Philippe [Radiation Oncology, Research Institute GROW of Oncology, Maastricht University Medical Center, Maastricht (Netherlands)

    2015-07-15

    Purpose: Although patients with stage III non-small cell lung cancer (NSCLC) are homogeneous according to the TNM staging system, they form a heterogeneous group, which is reflected in the survival outcome. The increasing amount of information for an individual patient and the growing number of treatment options facilitate personalized treatment, but they also complicate treatment decision making. Decision support systems (DSS), which provide individualized prognostic information, can overcome this but are currently lacking. A DSS for stage III NSCLC requires the development and integration of multiple models. The current study takes the first step in this process by developing and validating a model that can provide physicians with a survival probability for an individual NSCLC patient. Methods and Materials: Data from 548 patients with stage III NSCLC were available to enable the development of a prediction model, using stratified Cox regression. Variables were selected by using a bootstrap procedure. Performance of the model was expressed as the c statistic, assessed internally and on 2 external data sets (n=174 and n=130). Results: The final multivariate model, stratified for treatment, consisted of age, gender, World Health Organization performance status, overall treatment time, equivalent radiation dose, number of positive lymph node stations, and gross tumor volume. The bootstrapped c statistic was 0.62. The model could identify risk groups in external data sets. Nomograms were constructed to predict an individual patient's survival probability ( (www.predictcancer.org)). The data set can be downloaded at (https://www.cancerdata.org/10.1016/j.ijrobp.2015.02.048). Conclusions: The prediction model for overall survival of patients with stage III NSCLC highlights the importance of combining patient, clinical, and treatment variables. Nomograms were developed and validated. This tool could be used as a first building block for a decision support system.

  8. Proceedings of the symposium to review Volume III of the Annual Report to Congress

    Energy Technology Data Exchange (ETDEWEB)

    Alt, F.; Norland, D.

    1979-01-01

    This report is a transcript of the proceedings of a two-day Symposium, held in the Fall of 1979 at the University of Maryland in order to independently review the 1978 Energy Information Administration (EIA) Annual Report to Congress (ARC), Volume III. Participants included energy forecasting experts from the academic community and the private sector; other Federal, State, and local government energy experts; and Office of Applied Analysis, EIA, staff members. The Symposium and its transcript are a critique of the underlying 1978 ARC assumptions, methodologies, and energy system projections. Discussions cover the short-, mid-, and long-term periods, national and international forecasts, source and consuming sectors and projected economic impacts. 27 figures, 22 tables.

  9. Planning manual for energy resource development on Indian lands. Volume III. Manpower and training

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-01

    This volume addresses ways to bridge the gap between existing tribal skill levels and the skill levels required for higher-paying jobs in energy resource development projects. It addresses opportunities for technical, skilled, and semiskilled employment as well as professional positions, because it is important to have tribal participation at all levels of an operation. Section II, ''Energy-Related Employment Opportunities,'' covers three areas: (1) identification of energy-resource occupations; (2) description of these occupations; and (3) identification of skill requirements by type of occupation. Section III, ''Description of Training Programs,'' also covers three areas: (a) concept of a training-program model; (b) description of various training methods; and (c) an assessment of the cost of training, utilizing different programs. Section IV concentrates on development of a training program for target occupations, skills, and populations. Again this section covers three areas: (i) overview of the development of a skills training program; (ii) identification of target occupations, skills, and populations; and (iii) energy careers for younger tribal members.

  10. Incremental validity of the WJ III COG: Limited predictive effects beyond the GIA-E.

    Science.gov (United States)

    McGill, Ryan J; Busse, R T

    2015-09-01

    This study is an examination of the incremental validity of Cattell-Horn-Carroll (CHC) broad clusters from the Woodcock-Johnson III Tests of Cognitive Abilities (WJ III COG) for predicting scores on the Woodcock-Johnson III Tests of Achievement (WJ III ACH). The participants were children and adolescents, ages 6-18 (n = 4,722), drawn from the WJ III standardization sample. The sample was nationally stratified and proportional to U.S. census estimates for race/ethnicity, parent education level, and geographic region. Hierarchical multiple regression analyses were used to assess for cluster-level effects after controlling for the variance accounted for by the General Intellectual Ability-Extended (GIA-E) composite score. The results were interpreted using the R²/ΔR² statistic as the effect size indicator. Consistent with previous studies, the GIA-E accounted for statistically and clinically significant portions of WJ III ACH cluster score variance, with R2 values ranging from .29 to .56. WJ III COG CHC cluster scores collectively provided statistically significant incremental variance beyond the GIA-E in all of the regression models, although the effect sizes were consistently negligible to small (Average ΔR2(CHC) = .06), with significant effects observed only in the Oral Expression model (ΔR²(CHC) = .23). Individually, the WJ III COG cluster scores accounted for mostly small portions of achievement variance across the prediction models, with a large effect found for the Comprehension-Knowledge cluster in the Oral Expression model (ΔR²(Gc) = .23). The potential clinical and theoretical implications of these results are discussed.

  11. Prediction of the outcome of orthodontic treatment of Class III malocclusions--a systematic review

    NARCIS (Netherlands)

    Fudalej, P.S.; Dragan, M.; Wedrychowska-Szulc, B.

    2011-01-01

    The purpose of this study was to systematically review the orthodontic literature to assess the effectiveness of a prediction of outcome of orthodontic treatment in subjects with a Class III malocclusion. A structured search of electronic databases, as well as hand searching, retrieved 232 publicati

  12. Study for Teaching Behavioral Sciences in Schools of Medicine, Volume III: Behavioral Science Perspectives in Medical Education.

    Science.gov (United States)

    American Sociological Association, Washington, DC. Medical Sociology Council.

    Volume III of a study of teaching behavioral sciences in medical school presents perspectives on medical behavioral science from the viewpoints of the several behavioral disciplines (anthropology, psychology, sociology, political science, economics, behavioral biology and medical education). In addition, there is a discussion of translating…

  13. Financial constraints in capacity planning: a national utility regulatory model (NUREG). Volume I of III: methodology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-29

    This report develops and demonstrates the methodology for the National Utility Regulatory (NUREG) Model developed under contract number DEAC-01-79EI-10579. It is accompanied by two supporting volumes. Volume II is a user's guide for operation of the NUREG software. This includes description of the flow of software and data, as well as the formats of all user data files. Finally, Volume III is a software description guide. It briefly describes, and gives a listing of, each program used in NUREG.

  14. Prediction of type III secretion signals in genomes of gram-negative bacteria.

    Directory of Open Access Journals (Sweden)

    Martin Löwer

    Full Text Available BACKGROUND: Pathogenic bacteria infecting both animals as well as plants use various mechanisms to transport virulence factors across their cell membranes and channel these proteins into the infected host cell. The type III secretion system represents such a mechanism. Proteins transported via this pathway ("effector proteins" have to be distinguished from all other proteins that are not exported from the bacterial cell. Although a special targeting signal at the N-terminal end of effector proteins has been proposed in literature its exact characteristics remain unknown. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we demonstrate that the signals encoded in the sequences of type III secretion system effectors can be consistently recognized and predicted by machine learning techniques. Known protein effectors were compiled from the literature and sequence databases, and served as training data for artificial neural networks and support vector machine classifiers. Common sequence features were most pronounced in the first 30 amino acids of the effector sequences. Classification accuracy yielded a cross-validated Matthews correlation of 0.63 and allowed for genome-wide prediction of potential type III secretion system effectors in 705 proteobacterial genomes (12% predicted candidates protein, their chromosomes (11% and plasmids (13%, as well as 213 Firmicute genomes (7%. CONCLUSIONS/SIGNIFICANCE: We present a signal prediction method together with comprehensive survey of potential type III secretion system effectors extracted from 918 published bacterial genomes. Our study demonstrates that the analyzed signal features are common across a wide range of species, and provides a substantial basis for the identification of exported pathogenic proteins as targets for future therapeutic intervention. The prediction software is publicly accessible from our web server (www.modlab.org.

  15. Prediction of Molar Volumes of the Sudanese Reservoir Fluids

    Directory of Open Access Journals (Sweden)

    A. A. Rabah

    2010-01-01

    Full Text Available This paper provided important experimental PVT data of the Sudanese reservoir fluids. It includes composition analysis of 11 mixtures and about 148 PVT data points of constant mass expansion (CME tests at pressures below the bubble point. The datasets are compared with eight equations of state (EOS, namely, Peng Robinson (PR, Soave-Redlich-Kwong (SRK, Lawal-Lake-Silberberg (LLS, Adachi-Lu-Sugie (ALS, Schmidt-Wenzel (SW, Patel-Teja (PT, Modified-Nasrifar-Moshfeghian (MNM, and Harmens-Knapp (HK. The results of comparison reveals that, with the exception of PR and ALS EOSs, all other EOSs yield consistently a higher average absolute percent deviation (AAPD in the prediction of molar volume; it exceeds 20% by all mixtures. The grand average AAPD of all mixtures is 17 and 16 for PR and ALS, respectively. ALS is selected to represents the mixtures. It is modified by replacing the coefficient (Ωb1 of the parameter (b1 in the dominator of repulsive term by that of PR. This procedure enhanced the accuracy of ALS by 30 to 90% for individual mixtures and the grand average AAPD is significantly reduced from 16 to about 7.

  16. Dark Radiation predictions from general Large Volume Scenarios

    CERN Document Server

    Hebecker, Arthur; Rompineve, Fabrizio; Witkowski, Lukas T

    2014-01-01

    Recent observations constrain the amount of Dark Radiation ($\\Delta N_{\\rm eff}$) and may even hint towards a non-zero value of $\\Delta N_{\\rm eff}$. It is by now well-known that this puts stringent constraints on the sequestered Large Volume Scenario (LVS), i.e. on LVS realisations with the Standard Model at a singularity. We go beyond this setting by considering LVS models where SM fields are realised on 7-branes in the geometric regime. As we argue, this naturally goes together with high-scale supersymmetry. The abundance of Dark Radiation is determined by the competition between the decay of the lightest modulus to axions, to the SM Higgs and to gauge fields. The latter decay channel avoids the most stringent constraints of the sequestered setting. Nevertheless, a rather robust prediction for a substantial amount of Dark Radiation can be made. This applies both to cases where the SM 4-cycles are stabilised by D-terms and are small "by accident" as well as to fibred models with the small cycles stabilised ...

  17. A simple tool for mortality prediction in burns patients: APACHE III score and FTSA.

    Science.gov (United States)

    Moore, E C; Pilcher, D V; Bailey, M J; Cleland, H; McNamee, J

    2010-11-01

    Prediction of outcome for patients with major thermal injury is important to inform clinical decision making, alleviate individual suffering and improve hospital resource allocation. Age and burn size are widely accepted as the two largest contributors of mortality amongst burns patients. The APACHE (Acute Physiology and Chronic Health Evaluation) III-j score, which incorporates patient age, is also useful for mortality prediction, of intensive care populations. Validation for the burns specific cohort is unclear. A retrospective cohort study was performed on patients admitted to the Intensive Care Unit (ICU) via the Victorian Adult Burns Service (VABS), to compare observed mortality with burns specific markers of illness severity and APACHE III-j score. Our primary aim was to develop a mortality prediction tool for the burns population. Between January 1, 2002 and December 31, 2008, 228 patients were admitted to the ICU at The Alfred with acute burns. The mean age was 45.6 years and 81% (n=184) were male. Patients had severe injuries: the average percent TBSA (total body surface area) was 28% (IQR 10-40) and percent FTSA (full thickness surface area) was 18% (IQR 10-25). 86% (n=197) had airway involvement. Overall mortality in the 7-year period was 12% (n=27). Non-survivors were older, had larger and deeper burns, a higher incidence of deliberate self-harm, higher APACHE III-j scores and spent less time in hospital (but similar time in ICU), compared with survivors. Independent risk factors for death were percent FTSA (OR 1.03, 95% CI 1.01-1.05, p=0.01) and APACHE III-j score (OR 1.04, 95% CI 1.02-1.07, pAPACHE III-j score and percent FTSA. Prospective validation of our model on different burn populations is necessary.

  18. Predictive value of Pre-treatment Amygdala volume for Electroconvulsive Therapy Response in Severely Depressed Patients

    Directory of Open Access Journals (Sweden)

    Freek eTen Doesschate

    2014-11-01

    Full Text Available Background Electroconvulsive therapy (ECT is an effective treatment for patients with severe depression. Knowledge on factors predicting therapeutic response may help to identify patients who will benefit most from the intervention. Based on the neuroplasticity hypothesis, volumes of the amygdala and hippocampus are possible candidates for predicting treatment outcome. Therefore, this prospective cohort study examines the predictive value of amygdala and hippocampal volumes for the effectiveness of ECT.Methods Prior to ECT, 53 severely unipolar depressed patients (mean age 57±14 years; 40% [n=21] male received structural magnetic resonance imaging at 1.5 Tesla. Normalized amygdala and hippocampal volumes were calculated based on automatic segmentation by FreeSurfer. Regression analyses were used to test if the normalized volumes could predict the response to a course of ECT, based on the Montgomery-Åsberg Depression Rating Scale (MADRS scores. ResultsA larger amygdala volume independently and significantly predicted a lower post-ECT MADRS score (β = -0.347, P=0.013. The left amygdala volume had greater predictive value for treatment outcome relative to the right amygdala volume. Hippocampal volume had no independent predictive value.Conclusion A larger pretreatment amygdala volume predicted more effective ECT, independent of other known predictors. Almost all patients continued their medication during the study, which might have influenced the course of treatment in ways that were not taken into account.

  19. Underground Test Area Subproject Phase I Data Analysis Task. Volume III - Groundwater Recharge and Discharge Data Documentation Package

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-10-01

    Volume III of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the data covering groundwater recharge and discharge. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

  20. Technical and economic assessment of fluidized bed augmented compressed air energy storage system. Volume III. Preconceptual design

    Energy Technology Data Exchange (ETDEWEB)

    Giramonti, A.J.; Lessard, R.D.; Merrick, D.; Hobson, M.J.

    1981-09-01

    A technical and economic assessment of fluidized bed combustion augmented compressed air energy storage systems is presented. The results of this assessment effort are presented in three volumes. Volume III - Preconceptual Design contains the system analysis which led to the identification of a preferred component configuration for a fluidized bed combustion augmented compressed air energy storage system, the results of the effort which transformed the preferred configuration into preconceptual power plant design, and an introductory evaluation of the performance of the power plant system during part-load operation and while load following.

  1. Assessment of liver volume with spiral computerized tomography scanning: predicting liver volume by age and height

    Directory of Open Access Journals (Sweden)

    Madhu Sharma

    2016-07-01

    Conclusions: Liver volume is a reliable index of liver size and measurement of liver volume with spiral CT is useful method. Spiral CT can be utilized for measurement of liver volume for such purpose. [Int J Res Med Sci 2016; 4(7.000: 3020-3023

  2. Subcortical intelligence: caudate volume predicts IQ in healthy adults.

    Science.gov (United States)

    Grazioplene, Rachael G; G Ryman, Sephira; Gray, Jeremy R; Rustichini, Aldo; Jung, Rex E; DeYoung, Colin G

    2015-04-01

    This study examined the association between size of the caudate nuclei and intelligence. Based on the central role of the caudate in learning, as well as neuroimaging studies linking greater caudate volume to better attentional function, verbal ability, and dopamine receptor availability, we hypothesized the existence of a positive association between intelligence and caudate volume in three large independent samples of healthy adults (total N = 517). Regression of IQ onto bilateral caudate volume controlling for age, sex, and total brain volume indicated a significant positive correlation between caudate volume and intelligence, with a comparable magnitude of effect across each of the three samples. No other subcortical structures were independently associated with IQ, suggesting a specific biological link between caudate morphology and intelligence.

  3. In-treatment stroke volume predicts cardiovascular risk in hypertension

    DEFF Research Database (Denmark)

    Lønnebakken, Mai T; Gerdts, Eva; Boman, Kurt

    2011-01-01

    To evaluate whether lower stroke volume during antihypertensive treatment is a predictor of cardiovascular events independent of left ventricular geometric pattern. Methods: The association between left ventricular stroke volume and combined cardiovascular death, stroke and myocardial infarction......, the prespecified primary study endpoint, was assessed in Cox regression analysis using data from baseline and annual follow-up visits in 855 patients during 4.8 years of randomized losartan-based or atenolol-based treatment in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) echocardiography...... resistance, more concentric left ventricular geometry and impaired diastolic relaxation (all P treatment left ventricular stroke volume indexed for height2.04 was associated...

  4. Inside Out. Writings from the Prison Literacy Project. Volumes I-II.

    Science.gov (United States)

    Prison Literacy Project, Philadelphia, PA.

    These two volumes contain writings designed for the new reader who is in prison. Written by both inmates and external volunteers, the material in these volumes includes poems, stories, and short essays that deal with subjects of interest to prison inmates. To help the new reader, easier-to-read pieces are presented first. Titles in volume I are as…

  5. Prognostic and predictive value of YKL-40 in stage IIB-III melanoma

    DEFF Research Database (Denmark)

    Krogh, Merete; Christensen, Ib; Bouwhuis, Marna

    2016-01-01

    This study investigates the prognostic and predictive value of YKL-40 in stage IIB-III melanoma patients who were randomized to adjuvant interferon α-2b (IFN) or observation. Serum YKL-40 was determined postoperatively in patients from the Nordic IFN Trial (n=602), EORTC 18952 (n=246), and EORTC...... 18991 (n=386) (EORTC, European Organisation for Research and Treatment of Cancer). YKL-40 protein expression was determined in 300 tissue sections of primary melanoma or lymph node metastases from 204 Danish patients from the Nordic IFN Trial. Multivariate Cox analysis (including sex, age, stage...

  6. Isotopic prediction of eruption volume at continental volcanoes

    Energy Technology Data Exchange (ETDEWEB)

    Perry, F.V.; Valentine, G.A.; Crowe, B.M. [and others

    1997-10-01

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objective of this project was to determine whether isotopic techniques can be used to assess the eruption potential and eruption volume of continental stratovolcanoes. Large-volume eruptions from stratovolcanoes pose significant hazards to population and infrastructure in many parts of the world. We are testing whether this technique will allow a short- to medium-term (decades to millennia) probabilistic hazard assessment of large-volume eruptions. If successful, the technique will be useful to countries or regions that must consider medium to long-term volcanic (e.g., nuclear waste facilities). We have begun sample acquisition and isotopic measurements at two stratovolcanoes, Pico de Orizaba in eastern Mexico and Daisen in western Japan.

  7. NOVEL CONCEPTS FOR THE COMPRESSION OF LARGE VOLUMES OF CARBON DIOXIDE-PHASE III

    Energy Technology Data Exchange (ETDEWEB)

    Moore, J. Jeffrey; Allison, Timothy; Evans, Neal; Moreland, Brian; Hernandez, Augusto; Day, Meera; Ridens, Brandon

    2014-06-30

    successfully demonstrated good performance and mechanical behavior. In Phase III, a pilot compression plant consisting of a multi-stage centrifugal compressor with cooled diaphragm technology has been designed, constructed, and tested. Comparative testing of adiabatic and cooled tests at equivalent inlet conditions shows that the cooled diaphragms reduce power consumption by 3-8% when the compressor is operated as a back-to-back unit and by up to 9% when operated as a straight-though compressor with no intercooler. The power savings, heat exchanger effectiveness, and temperature drops for the cooled diaphragm were all slightly higher than predicted values but showed the same trends.

  8. Pituitary Volume Prospectively Predicts Internalizing Symptoms in Adolescence

    Science.gov (United States)

    Zipursky, Amy R.; Whittle, Sarah; Yucel, Murat; Lorenzetti, Valentina; Wood, Stephen J.; Lubman, Dan I.; Simmons, Julian G.; Allen, Nicholas B.

    2011-01-01

    Background: Early adolescence is a critical time for the development of both internalizing and externalizing disorders. We aimed to investigate whether pituitary volume, an index of hypothalamic-pituitary-adrenal (HPA) axis function, represents a vulnerability factor for the emergence of internalizing and externalizing symptoms during adolescence…

  9. Pituitary Volume Prospectively Predicts Internalizing Symptoms in Adolescence

    Science.gov (United States)

    Zipursky, Amy R.; Whittle, Sarah; Yucel, Murat; Lorenzetti, Valentina; Wood, Stephen J.; Lubman, Dan I.; Simmons, Julian G.; Allen, Nicholas B.

    2011-01-01

    Background: Early adolescence is a critical time for the development of both internalizing and externalizing disorders. We aimed to investigate whether pituitary volume, an index of hypothalamic-pituitary-adrenal (HPA) axis function, represents a vulnerability factor for the emergence of internalizing and externalizing symptoms during adolescence…

  10. The 2012 Brown Center Report on American Education: How Well Are American Students Learning? With Sections on Predicting the Effect of the Common Core State Standards, Achievement Gaps on the Two NAEP Tests, and Misinterpreting International Test Scores. Volume III, Number 1

    Science.gov (United States)

    Loveless, Tom

    2012-01-01

    This edition of the Brown Center Report on American Education marks the first issue of volume three--and eleventh issue over all. The first installment was published in 2000, just as the Presidential campaigns of George W. Bush and Al Gore were winding down. Education was an important issue in that campaign. It has not been thus far in the current…

  11. How To Set Up Your Own Small Business. Volumes I-II and Overhead Transparencies.

    Science.gov (United States)

    Fallek, Max

    This two-volume textbook and collection of overhead transparency masters is intended for use in a course in setting up a small business. The following topics are covered in the first volume: getting off to a good start, doing market research, forecasting sales, financing a small business, understanding the different legal needs of different types…

  12. Coordination properties of warfarin towards Pr(III) predicted from DFT and FT-IR studies

    Energy Technology Data Exchange (ETDEWEB)

    Mihaylov, Tz., E-mail: tzmihay@svr.igic.bas.bg [Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia (Bulgaria); Trendafilova, N.; Georgieva, I. [Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia (Bulgaria); Kostova, I., E-mail: irenakostova@yahoo.com [Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia (Bulgaria)

    2010-08-23

    Graphical abstract: The coordination behavior of warfarin towards Pr(III) in Pr(L){sub 3}.5H{sub 2}O complex (L - warfarin) is investigated through molecular modeling at B3LYP/6-31G(d,p) level and consequent exhaustive comparative vibrational analysis of the ligand and the complex. The calculations predicted that the ligand binds to the metal through the deprotonated enol group and the keto C=O group in pseudo-octahedral polyhedron. The simulated vibrational spectrum of the model complex proposed is in excellent agreement with the experimental one. - Abstract: The coordination behavior of warfarin towards Pr(III) in Pr(L){sub 3}.5H{sub 2}O complex (L - warfarin) is investigated through molecular modeling at B3LYP/6-31G(d,p) level and consequent exhaustive comparative vibrational analysis of the ligand and the complex. The calculated NPA charges, Fukui functions and MEP values of the anionic ligand in solution pointed out that the oxygen atoms of the deprotonated hydroxyl and the coumarin carbonyl groups are the most probable reactive sites upon coordination. The metal-ligand binding mode of warfarin is predicted through molecular modeling and energy estimation of different Pr(III)-warfarin structures. In the most stable model structure, the ligand-metal binding is realized through the oxygen of the deprotonated OH group and the oxygen of the keto C=O group in pseudo-octahedral polyhedron. The suggested metal-ligand binding mode is confirmed by comparative vibrational analysis of the free ligand and various model structures with different metal-ligand binding modes.

  13. Extended SUSY SU(5) predicting type-III seesaw testable at LHC

    CERN Document Server

    Awasthi, Ram Lal

    2013-01-01

    We propose an extension of the SUSY SU(5) which predicts LHC testable type-III seesaw. The supersymmetric SU(5) GUT model is extended by adding a 24-plet matter superfield along with a pair of $10_H$-plet and $\\bar{10}_H$-plet Higgs superfields. The 24-plet carries a triplet and a singlet fermion multiplet of SU(2)$_L$, which leads to type I+III seesaw. The additional $10_H$ (and $\\bar{10}_H$) multiplets help in achieving gauge coupling unification while keeping the triplet fermion mass in the TeV range, making them accessible at LHC. We study the phenomenology of this model in detail. Large lepton flavor violation predicted in this model puts severe constraints on the Yukawa couplings of the triplet fermion. We show that this smothers the possibility of observing the contribution of the heavy fermions in neutrinoless double beta decay experiments. The presence of the additional $10_H$ and $\\bar{10}_H$ in this model not only gives gauge coupling unification, it also leads to very large lepton flavor violation...

  14. Web search queries can predict stock market volumes.

    Science.gov (United States)

    Bordino, Ilaria; Battiston, Stefano; Caldarelli, Guido; Cristelli, Matthieu; Ukkonen, Antti; Weber, Ingmar

    2012-01-01

    We live in a computerized and networked society where many of our actions leave a digital trace and affect other people's actions. This has lead to the emergence of a new data-driven research field: mathematical methods of computer science, statistical physics and sociometry provide insights on a wide range of disciplines ranging from social science to human mobility. A recent important discovery is that search engine traffic (i.e., the number of requests submitted by users to search engines on the www) can be used to track and, in some cases, to anticipate the dynamics of social phenomena. Successful examples include unemployment levels, car and home sales, and epidemics spreading. Few recent works applied this approach to stock prices and market sentiment. However, it remains unclear if trends in financial markets can be anticipated by the collective wisdom of on-line users on the web. Here we show that daily trading volumes of stocks traded in NASDAQ-100 are correlated with daily volumes of queries related to the same stocks. In particular, query volumes anticipate in many cases peaks of trading by one day or more. Our analysis is carried out on a unique dataset of queries, submitted to an important web search engine, which enable us to investigate also the user behavior. We show that the query volume dynamics emerges from the collective but seemingly uncoordinated activity of many users. These findings contribute to the debate on the identification of early warnings of financial systemic risk, based on the activity of users of the www.

  15. Web search queries can predict stock market volumes.

    Directory of Open Access Journals (Sweden)

    Ilaria Bordino

    Full Text Available We live in a computerized and networked society where many of our actions leave a digital trace and affect other people's actions. This has lead to the emergence of a new data-driven research field: mathematical methods of computer science, statistical physics and sociometry provide insights on a wide range of disciplines ranging from social science to human mobility. A recent important discovery is that search engine traffic (i.e., the number of requests submitted by users to search engines on the www can be used to track and, in some cases, to anticipate the dynamics of social phenomena. Successful examples include unemployment levels, car and home sales, and epidemics spreading. Few recent works applied this approach to stock prices and market sentiment. However, it remains unclear if trends in financial markets can be anticipated by the collective wisdom of on-line users on the web. Here we show that daily trading volumes of stocks traded in NASDAQ-100 are correlated with daily volumes of queries related to the same stocks. In particular, query volumes anticipate in many cases peaks of trading by one day or more. Our analysis is carried out on a unique dataset of queries, submitted to an important web search engine, which enable us to investigate also the user behavior. We show that the query volume dynamics emerges from the collective but seemingly uncoordinated activity of many users. These findings contribute to the debate on the identification of early warnings of financial systemic risk, based on the activity of users of the www.

  16. Web Search Queries Can Predict Stock Market Volumes

    Science.gov (United States)

    Bordino, Ilaria; Battiston, Stefano; Caldarelli, Guido; Cristelli, Matthieu; Ukkonen, Antti; Weber, Ingmar

    2012-01-01

    We live in a computerized and networked society where many of our actions leave a digital trace and affect other people’s actions. This has lead to the emergence of a new data-driven research field: mathematical methods of computer science, statistical physics and sociometry provide insights on a wide range of disciplines ranging from social science to human mobility. A recent important discovery is that search engine traffic (i.e., the number of requests submitted by users to search engines on the www) can be used to track and, in some cases, to anticipate the dynamics of social phenomena. Successful examples include unemployment levels, car and home sales, and epidemics spreading. Few recent works applied this approach to stock prices and market sentiment. However, it remains unclear if trends in financial markets can be anticipated by the collective wisdom of on-line users on the web. Here we show that daily trading volumes of stocks traded in NASDAQ-100 are correlated with daily volumes of queries related to the same stocks. In particular, query volumes anticipate in many cases peaks of trading by one day or more. Our analysis is carried out on a unique dataset of queries, submitted to an important web search engine, which enable us to investigate also the user behavior. We show that the query volume dynamics emerges from the collective but seemingly uncoordinated activity of many users. These findings contribute to the debate on the identification of early warnings of financial systemic risk, based on the activity of users of the www. PMID:22829871

  17. Predicting patient volume in cardiac catheterization laboratory to improve resource management.

    Science.gov (United States)

    Liu, Jianhua; Santangelo, Jennifer; James, Randy; Watters, Coyt D; Orsini, Anthony; Mekhjian, Hagop; Kamal, Jyoti

    2008-11-06

    Using historical data within the Information Warehouse of the Ohio State University Medical Center, prediction on daily patient volume to catheterization laboratory was attempted to facilitate resource management and planning.

  18. AIR QUALITY CRITERIA FOR PARTICULATE MATTER, VOLUMES I-III, (EXTERNAL REVIEW DRAFT, 1995)

    Science.gov (United States)

    There is no abstract available for these documents. If further information is requested, please refer to the bibliographic citation and contact the Technical Information Staff at the number listed above.Air Quality Criteria for Particulate Matter, Volume I, Extern...

  19. Field Surveys, IOC Valleys. Volume III, Part I. Cultural Resources Survey, Dry Lake Valley, Nevada.

    Science.gov (United States)

    1981-08-01

    Artemisia nova) but also include cliffrose (Cowania mexicana ) and broom snakeweed (Gutierrezia sarothreae) as dominant species. Other species include... CULTURA Ale ~~REOUC SURVEYa AREASczCAvE L CU 11U CUUI 3-2 E-TR-48-III-I 69 was used because it is considered intensive by the Bureau of Land Management and

  20. ICPP calcined solids storage facility closure study. Volume III: Engineering design files

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The following information was calculated to support cost estimates and radiation exposure calculations for closure activities at the Calcined Solids Storage Facility (CSSF). Within the estimate, volumes were calculated to determine the required amount of grout to be used during closure activities. The remaining calcine on the bin walls, supports, piping, and floor was also calculated to approximate the remaining residual calcine volumes at different stages of the removal process. The estimates for remaining calcine and vault void volume are higher than what would actually be experienced in the field, but are necessary for bounding purposes. The residual calcine in the bins may be higher than was is experienced in the field as it was assumed that the entire bin volume is full of calcine before removal activities commence. The vault void volumes are higher as the vault roof beam volumes were neglected. The estimations that follow should be considered rough order of magnitude, due to the time constraints as dictated by the project`s scope of work. Should more accurate numbers be required, a new analysis would be necessary.

  1. Novel concepts for the compression of large volumes of carbon dioxide-phase III

    Energy Technology Data Exchange (ETDEWEB)

    Moore, J. Jeffrey [Southwest Research Inst., San Antonio, TX (United States); Allison, Timothy C. [Southwest Research Inst., San Antonio, TX (United States); Evans, Neal D. [Southwest Research Inst., San Antonio, TX (United States); Moreland, Brian [Southwest Research Inst., San Antonio, TX (United States); Hernandez, Augusto J. [Southwest Research Inst., San Antonio, TX (United States); Day, Meera [Southwest Research Inst., San Antonio, TX (United States); Ridens, Brandon L. [Southwest Research Inst., San Antonio, TX (United States)

    2014-06-30

    and tested in a closed loop compressor facility using CO2 . Both test programs successfully demonstrated good performance and mechanical behavior. In Phase III, a pilot compression plant consisting of a multi-stage centrifugal compressor with cooled diaphragm technology has been designed, constructed, and tested. Comparative testing of adiabatic and cooled tests at equivalent inlet conditions shows that the cooled diaphragms reduce power consumption by 3-8% when the compressor is operated as a back-to-back unit and by up to 9% when operated as a straight-though compressor with no intercooler. The power savings, heat exchanger effectiveness, and temperature drops for the cooled diaphragm were all slightly higher than predicted values but showed the same trends.

  2. Mean platelet volume (MPV predicts middle distance running performance.

    Directory of Open Access Journals (Sweden)

    Giuseppe Lippi

    Full Text Available Running economy and performance in middle distance running depend on several physiological factors, which include anthropometric variables, functional characteristics, training volume and intensity. Since little information is available about hematological predictors of middle distance running time, we investigated whether some hematological parameters may be associated with middle distance running performance in a large sample of recreational runners.The study population consisted in 43 amateur runners (15 females, 28 males; median age 47 years, who successfully concluded a 21.1 km half-marathon at 75-85% of their maximal aerobic power (VO2max. Whole blood was collected 10 min before the run started and immediately thereafter, and hematological testing was completed within 2 hours after sample collection.The values of lymphocytes and eosinophils exhibited a significant decrease compared to pre-run values, whereas those of mean corpuscular volume (MCV, platelets, mean platelet volume (MPV, white blood cells (WBCs, neutrophils and monocytes were significantly increased after the run. In univariate analysis, significant associations with running time were found for pre-run values of hematocrit, hemoglobin, mean corpuscular hemoglobin (MCH, red blood cell distribution width (RDW, MPV, reticulocyte hemoglobin concentration (RetCHR, and post-run values of MCH, RDW, MPV, monocytes and RetCHR. In multivariate analysis, in which running time was entered as dependent variable whereas age, sex, blood lactate, body mass index, VO2max, mean training regimen and the hematological parameters significantly associated with running performance in univariate analysis were entered as independent variables, only MPV values before and after the trial remained significantly associated with running time. After adjustment for platelet count, the MPV value before the run (p = 0.042, but not thereafter (p = 0.247, remained significantly associated with running

  3. TFaNS Tone Fan Noise Design/Prediction System. Volume 1; System Description, CUP3D Technical Documentation and Manual for Code Developers

    Science.gov (United States)

    Topol, David A.

    1999-01-01

    TFaNS is the Tone Fan Noise Design/Prediction System developed by Pratt & Whitney under contract to NASA Lewis (presently NASA Glenn). The purpose of this system is to predict tone noise emanating from a fan stage including the effects of reflection and transmission by the rotor and stator and by the duct inlet and nozzle. These effects have been added to an existing annular duct/isolated stator noise prediction capability. TFaNS consists of: The codes that compute the acoustic properties (reflection and transmission coefficients) of the various elements and write them to files. Cup3D: Fan Noise Coupling Code that reads these files, solves the coupling problem, and outputs the desired noise predictions. AWAKEN: CFD/Measured Wake Postprocessor which reformats CFD wake predictions and/or measured wake data so it can be used by the system. This volume of the report provides technical background for TFaNS including the organization of the system and CUP3D technical documentation. This document also provides information for code developers who must write Acoustic Property Files in the CUP3D format. This report is divided into three volumes: Volume I: System Description, CUP3D Technical Documentation, and Manual for Code Developers; Volume II: User's Manual, TFaNS Vers. 1.4; Volume III: Evaluation of System Codes.

  4. Quantitative prediction of respiratory tidal volume based on the external torso volume change: a potential volumetric surrogate

    Energy Technology Data Exchange (ETDEWEB)

    Li Guang; Arora, Naveen C; Xie Huchen; Ning, Holly; Citrin, Deborah; Kaushal, Aradhana; Zach, Leor; Camphausen, Kevin; Miller, Robert W [Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States); Lu Wei; Low, Daniel [Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110 (United States)], E-mail: ligeorge@mail.nih.gov

    2009-04-07

    An external respiratory surrogate that not only highly correlates with but also quantitatively predicts internal tidal volume should be useful in guiding four-dimensional computed tomography (4DCT), as well as 4D radiation therapy (4DRT). A volumetric surrogate should have advantages over external fiducial point(s) for monitoring respiration-induced motion of the torso, which deforms in synchronization with a patient-specific breathing pattern. This study establishes a linear relationship between the external torso volume change (TVC) and lung air volume change (AVC) by validating a proposed volume conservation hypothesis (TVC = AVC) throughout the respiratory cycle using 4DCT and spirometry. Fourteen patients' torso 4DCT images and corresponding spirometric tidal volumes were acquired to examine this hypothesis. The 4DCT images were acquired using dual surrogates in cine mode and amplitude-based binning in 12 respiratory stages, minimizing residual motion artifacts. Torso and lung volumes were calculated using threshold-based segmentation algorithms and volume changes were calculated relative to the full-exhalation stage. The TVC and AVC, as functions of respiratory stages, were compared, showing a high correlation (r = 0.992 {+-} 0.005, p < 0.0001) as well as a linear relationship (slope = 1.027 {+-} 0.061, R{sup 2} = 0.980) without phase shift. The AVC was also compared to the spirometric tidal volumes, showing a similar linearity (slope = 1.030 {+-} 0.092, R{sup 2} = 0.947). In contrast, the thoracic and abdominal heights measured from 4DCT showed relatively low correlation (0.28 {+-} 0.44 and 0.82 {+-} 0.30, respectively) and location-dependent phase shifts. This novel approach establishes the foundation for developing an external volumetric respiratory surrogate.

  5. Compact high order finite volume method on unstructured grids III: Variational reconstruction

    Science.gov (United States)

    Wang, Qian; Ren, Yu-Xin; Pan, Jianhua; Li, Wanai

    2017-05-01

    This paper presents a variational reconstruction for the high order finite volume method in solving the two-dimensional Navier-Stokes equations on arbitrary unstructured grids. In the variational reconstruction, an interfacial jump integration is defined to measure the jumps of the reconstruction polynomial and its spatial derivatives on each cell interface. The system of linear equations to determine the reconstruction polynomials is derived by minimizing the total interfacial jump integration in the computational domain using the variational method. On each control volume, the derived equations are implicit relations between the coefficients of the reconstruction polynomials defined on a compact stencil involving only the current cell and its direct face-neighbors. The reconstruction and time integration coupled iteration method proposed in our previous paper is used to achieve high computational efficiency. A problem-independent shock detector and the WBAP limiter are used to suppress non-physical oscillations in the simulation of flow with discontinuities. The advantages of the finite volume method using the variational reconstruction over the compact least-squares finite volume method proposed in our previous papers are higher accuracy, higher computational efficiency, more flexible boundary treatment and non-singularity of the reconstruction matrix. A number of numerical test cases are solved to verify the accuracy, efficiency and shock-capturing capability of the finite volume method using the variational reconstruction.

  6. Proceedings of the sixth international conference on fluidized bed combustion. Volume III. Technical sessions

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-08-01

    The Sixth International Conference on Fluidized Bed Combustion was held April 9-11, 1980, at the Atlanta Hilton, Atlanta, Georgia. It was sponsored by the US Department of Energy, the Electric Power Research Institute, the US Environmental Protection Agency, and the Tennessee Valley Authority. Forty-five papers from Vol. III of the proceedings have been entered individually into EDB and ERA. Two papers had been entered previously from other sources. (LTN)

  7. Recent regulatory experience of low-Btu coal gasification. Volume III. Supporting case studies

    Energy Technology Data Exchange (ETDEWEB)

    Ackerman, E.; Hart, D.; Lethi, M.; Park, W.; Rifkin, S.

    1980-02-01

    The MITRE Corporation conducted a five-month study for the Office of Resource Applications in the Department of Energy on the regulatory requirements of low-Btu coal gasification. During this study, MITRE interviewed representatives of five current low-Btu coal gasification projects and regulatory agencies in five states. From these interviews, MITRE has sought the experience of current low-Btu coal gasification users in order to recommend actions to improve the regulatory process. This report is the third of three volumes. It contains the results of interviews conducted for each of the case studies. Volume 1 of the report contains the analysis of the case studies and recommendations to potential industrial users of low-Btu coal gasification. Volume 2 contains recommendations to regulatory agencies.

  8. Alterations of thoraco-abdominal volumes and asynchronies in patients with spinal muscle atrophy type III.

    Science.gov (United States)

    LoMauro, Antonella; Romei, Marianna; Priori, Rita; Laviola, Marianna; D'Angelo, Maria Grazia; Aliverti, Andrea

    2014-06-15

    Spinal muscular atrophy (SMA) is characterized by degeneration of motor neurons resulting in muscle weakness. For the mild type III form, a sub-classification into type IIIA and IIIB, based on age of motor impairment, was recently proposed. To investigate if SMA IIIA (more severe) and IIIB differ also in terms of respiratory function, thoracoabdominal kinematics was measured during quiet breathing, inspiration preceding cough and inspiratory capacity on 5 type IIIA and 9 type IIIB patients. Four patients with SMA II (more severe than types III) and 19 healthy controls were also studied. Rib cage motion was similar in SMA IIIB and controls. Conversely, in SMA IIIA and SMA II it was significantly reduced and sometime paradoxical during quiet breathing in supine position. Our results suggest that in SMA IIIA intercostal muscles are weakened and the diaphragm is preserved similarly to SMA II, while in SMA IIIB the action of all inspiratory muscles is maintained. Sub-classification of type III seems feasible also for respiratory function.

  9. Recensione a "Collodi. Edizione Nazionale delle Opere di Carlo Lorenzini. Volume III"

    Directory of Open Access Journals (Sweden)

    Pina Paone

    2013-06-01

    Full Text Available Si presenta il terzo volume della collana Collodi, Edizione Nazionale delle Opere di Carlo Lorenzini, Giunti, Firenze, 2012, con Prefazione di Mario Vargas Llosa e Introduzione di Daniela Marcheschi. Il volume contiene il famosissimo Le Avventure di Pinocchio, sintesi del percorso artistico dello scrittore toscano ed espressione più compiuta della sua abilità e consapevolezza narrativa. La recensione ripercorrerà i tratti dell’opera, inserendola nel generale e più ampio contesto dell’attività letteraria di Collodi.

  10. Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs

    Directory of Open Access Journals (Sweden)

    Teiji Sawa

    2016-10-01

    Full Text Available Pseudomonas aeruginosa ExoU, a type III secretory toxin and major virulence factor with patatin-like phospholipase activity, is responsible for acute lung injury and sepsis in immunocompromised patients. Through use of a recently updated bacterial genome database, protein sequences predicted to be homologous to Ps. aeruginosa ExoU were identified in 17 other Pseudomonas species (Ps. fluorescens, Ps. lundensis, Ps. weihenstephanensis, Ps. marginalis, Ps. rhodesiae, Ps. synxantha, Ps. libanensis, Ps. extremaustralis, Ps. veronii, Ps. simiae, Ps. trivialis, Ps. tolaasii, Ps. orientalis, Ps. taetrolens, Ps. syringae, Ps. viridiflava, and Ps. cannabina and 8 Gram-negative bacteria from three other genera (Photorhabdus, Aeromonas, and Paludibacterium. In the alignment of the predicted primary amino acid sequences used for the phylogenetic analyses, both highly conserved and nonconserved parts of the toxin were discovered among the various species. Further comparative studies of the predicted ExoU homologs should provide us with more detailed information about the unique characteristics of the Ps. aeruginosa ExoU toxin.

  11. Midlife memory improvement predicts preservation of hippocampal volume in old age.

    Science.gov (United States)

    Borghesani, Paul R; Weaver, Kurt E; Aylward, Elizabeth H; Richards, Anne L; Madhyastha, Tara M; Kahn, Ali R; Liang, Olivia; Ellenbogen, Rachel L; Beg, M Faisal; Schaie, K Warner; Willis, Sherry L

    2012-07-01

    This study examines whether midlife change in episodic memory predicts hippocampal volume in old age. From the Seattle Longitudinal Study we retrospectively identified 84 healthy, cognitively normal individuals, age 52 to 87, whose episodic memory had reliably declined (n = 33), improved (n = 28) or remained stable (n = 23) over a 14-year period in midlife (age 43-63). Midlife memory improvement was associated with 13% larger hippocampal volume (p volume for those currently in late middle age (age 52-65). The pattern of findings was not modified by gender, apolipoprotein ε4 status, education or current memory performance. Change in midlife memory scores over 14 years, but not any single assessment, predicted hippocampal volumes in old age, emphasizing the importance of longitudinal data in examining brain-cognition relationships. These findings suggest that improvement in memory in midlife is associated with sparing of hippocampal volume in later life.

  12. Prognostic and predictive value of liver volume on colorectal cancer patients with unresectable liver metastases

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jun Su; Park, Hee Chul; Choi, Doo Ho; Park, Won; Yu, Jeong Il; Park, Young Suk; Kang, Won Ki; Park, Joon Oh [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2014-06-15

    To determine the prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases. Sixteen patients received whole liver radiotherapy (WLRT) between January 1997 and June 2013. A total dose of 21 Gy was delivered in 7 fractions. The median survival time after WLRT was 9 weeks. In univariate analysis, performance status, serum albumin and total bilirubin level, liver volume and extrahepatic metastases were associated with survival. The mean liver volume was significantly different between subgroups with and without pain relief (3,097 and 4,739 mL, respectively; p = 0.002). A larger liver volume is a poor prognostic factor for survival and also a negative predictive factor for response to WLRT. If patients who are referred for WLRT have large liver volume, they should be informed of the poor prognosis and should be closely observed during and after WLRT.

  13. Monitoring and Evaluation of Smolt Migration in the Columbia River Basin : Volume III : Evaluation of the 1997 Predictions of the Run-Timing of Wild Migrant Yearling and Subyearling Chinook and Sockeye in the Snake River Basin Using Program RealTime.

    Energy Technology Data Exchange (ETDEWEB)

    Townsend, Richard L.

    1998-07-01

    Since the 1994 outmigration, program RealTime has been applied to provide in-season predictions of smolt outmigration timing for individual and aggregates of listed threatened and endangered Snake River salmon stocks. Results from the 1997 smolt outmigrations of wild Snake River yearling and subyearling chinook show prediction of run-timing can be accurately forecasted. The number of release sites meeting previous years criteria for RealTime forecasts dropped to five for the wild spring/summer chinook parr PIT-tagged in 1996: Catherine Creek, Imnaha, Lostine, Minam and South Fork Salmon Rivers. An experiment in lessening previous RealTime requirements for forecasting a outmigration in progress added three release sites of chinook: Lake Creek, Secesh and South Fork Wenaha Rivers; and one release of age 1+ sockeye at Redfish Lake. Passage indices provided by the Fish Passage Center for Lower Granite Dam were monitored for the wild subyearling chinook outmigration. Investigation continued into basing predictions on historical years with similar flows as a way to improve forecasting performance for the wild subyearling outmigration. Program RealTime's output is a series of estimated percentages of the status of the smolt outmigration throughout the season. To compare the performance the program from year to year, or to compare various assumptions used set up the forecasting, the mean absolute deviance (MAD) of the daily predicted outmigration-proportion from the actual outmigration-proportion is calculated post-season. Furthermore, these MAD's are considered for three periods of the season: the first 50% of the season, the second 50%, and the entire season.

  14. Investigation into the prediction accuracy of photocephalometry for skeletal Class III adult female patients treated with two-jaw surgery

    Directory of Open Access Journals (Sweden)

    Shiu-Shiung Lin

    2012-06-01

    Conclusions: In this study predictions were generally accurate in skeletal Class III adult female patients treated with two-jaw surgery. Compared to surgical outcomes, the predictions tended to locate the nasal base more inferior and the lower lip in a more superior position. Prediction inaccuracies and large individual variations found in this report were associated with difficulties in manual photographic manipulation and weak correlations in the vertical direction between the hard tissues and their corresponding soft tissues.

  15. Secretarial Science. Curriculum Guides for Two-Year Postsecondary Programs. Volume III.

    Science.gov (United States)

    North Carolina State Dept. of Community Colleges, Raleigh.

    The third of three volumes in a postsecondary secretarial science curriculum, this manual contains course syllabi for thirteen secretarial science technical courses. Course titles include Shorthand 1-3; Shorthand Dictation and Transcription, 1-3; Terminology and Vocabulary: Business, Legal, Medical; Typewriting, 1-5; and Word Processing. Each…

  16. Analysis and forecast of electrical distribution system materials. Final report. Volume III. Appendix

    Energy Technology Data Exchange (ETDEWEB)

    Love, C G

    1976-08-23

    These appendixes are referenced in Volume II of this report. They contain the detailed electrical distribution equipment requirements and input material requirements forecasts. Forecasts are given for three electric energy usage scenarios. Also included are data on worldwide reserves and demand for 30 raw materials required for the manufacture of electrical distribution equipment.

  17. Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma.

    Science.gov (United States)

    Mandel, Jacob J; Yust-Katz, Shlomit; Patel, Akash J; Cachia, David; Liu, Diane; Park, Minjeong; Yuan, Ying; A Kent, Thomas; de Groot, John F

    2017-07-31

    Glioblastoma is the most common primary malignant brain tumor in adults, but effective therapies are lacking. With the scarcity of positive phase III trials, which are increasing in cost, we examined the ability of positive phase II trials to predict statistically significant improvement in clinical outcomes of phase III trials. A PubMed search was conducted to identify phase III clinical trials performed in the past 25 years for patients with newly diagnosed or recurrent glioblastoma. Trials were excluded if they did not examine an investigational chemotherapy or agent, if they were stopped early owing to toxicity, if they lacked prior phase II studies, or if a prior phase II study was negative. Seven phase III clinical trials in newly diagnosed glioblastoma and 4 phase III clinical trials in recurrent glioblastoma met the inclusion criteria. Only 1 (9%) phase III study documented an improvement in overall survival and changed the standard of care. The high failure rate of phase III trials demonstrates the urgent need to increase the reliability of phase II trials of treatments for glioblastoma. Strategies such as the use of adaptive trial designs, Bayesian statistics, biomarkers, volumetric imaging, and mathematical modeling warrant testing. Additionally, it is critical to increase our expectations of phase II trials so that positive findings increase the probability that a phase III trial will be successful.

  18. Does upper premolar extraction affect the changes of pharyngeal airway volume after bimaxillary surgery in skeletal class III patients?

    Science.gov (United States)

    Kim, Min-Ah; Park, Yang-Ho

    2014-01-01

    The purpose of this study was to assess the pharyngeal airway volume change after bimaxillary surgery in patients with skeletal Class III malocclusion and evaluate the difference in postoperative pharyngeal airway space between upper premolar extraction cases and nonextraction cases. Cone-beam computed tomographic scans were obtained for 23 patients (13 in extraction group and 10 in nonextraction group) who were diagnosed with mandibular prognathism before surgery (T0) and then 2 months (T2) and 6 months after surgery (T3). Using InVivoDental 3-dimensional imaging software, volumetric changes in the pharyngeal airway space were assessed at T0, T2, and T3. The Wilcoxon signed-rank test was used to determine whether there were significant changes in pharyngeal airway volume between time points. The Mann-Whitney U test was used to determine whether there were significant differences in volumetric changes between the extraction and nonextraction groups. Volumes in all subsections of the pharyngeal airway were decreased (P bimaxillary surgery. Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  19. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study.

    Science.gov (United States)

    Erickson, K I; Raji, C A; Lopez, O L; Becker, J T; Rosano, C; Newman, A B; Gach, H M; Thompson, P M; Ho, A J; Kuller, L H

    2010-10-19

    Physical activity (PA) has been hypothesized to spare gray matter volume in late adulthood, but longitudinal data testing an association has been lacking. Here we tested whether PA would be associated with greater gray matter volume after a 9-year follow-up, a threshold could be identified for the amount of walking necessary to spare gray matter volume, and greater gray matter volume associated with PA would be associated with a reduced risk for cognitive impairment 13 years after the PA evaluation. In 299 adults (mean age 78 years) from the Cardiovascular Health Cognition Study, we examined the association between gray matter volume, PA, and cognitive impairment. Physical activity was quantified as the number of blocks walked over 1 week. High-resolution brain scans were acquired 9 years after the PA assessment on cognitively normal adults. White matter hyperintensities, ventricular grade, and other health variables at baseline were used as covariates. Clinical adjudication for cognitive impairment occurred 13 years after baseline. Walking amounts ranged from 0 to 300 blocks (mean 56.3; SD 69.7). Greater PA predicted greater volumes of frontal, occipital, entorhinal, and hippocampal regions 9 years later. Walking 72 blocks was necessary to detect increased gray matter volume but walking more than 72 blocks did not spare additional volume. Greater gray matter volume with PA reduced the risk for cognitive impairment 2-fold. Greater amounts of walking are associated with greater gray matter volume, which is in turn associated with a reduced risk of cognitive impairment.

  20. Use of steel slag as a granular material: volume expansion prediction and usability criteria.

    Science.gov (United States)

    Wang, George; Wang, Yuhong; Gao, Zhili

    2010-12-15

    The theoretical equation for predicting volume expansion of steel slag is deduced based on both chemical reaction and physical changes of free lime in steel slag during the hydration process. Laboratory volume expansion testing is conducted to compare the results with the theoretical volume expansion. It is proved that they correlated well. It is furthermore experimentally proved that certain volume expansion of steel slag can be absorbed internally by the void volume in bulk steel slag under external surcharge weight making the apparent volume expansion equal zero. The minimum (lowest) absorbable void volume is approximately 7.5%, which is unrelated to the free lime content. A usability criterion is then developed based on the volume expansion of steel slag (%) and the minimum percentage of the volume that can take the volume expansion of steel slag (%). Eventually the criterion (relationship) is established based on the free lime content, the specific gravity and bulk relative gravity of a specific steel slag sample. The criteria can be used as guidance and specification for the use of steel slag and other expansion-prone nonferrous slags, copper, nickel for instance as a granular material in highway construction.

  1. Economic evaluation of the annual cycle energy system (ACES). Final report. Volume III, appendices

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    This volume consists of seven appendices related to ACES, the first three of which are concerned with computer programs. The appendices are entitled: (A) ACESIM: Residential Program Listing; (B) Typical Inputs and Outputs of ACESIM; (C) CACESS: Commercial Building Program Listing; (D) Typical Weather-Year Selection Requirements; (E) Building Characteristics; (F) List of Major Variables Used in the Computer Programs; and (G) Bibliography. 79 references.

  2. Freud on Holiday. Volume III. The Forgetting of a Foreign Name

    OpenAIRE

    Kivland, Sharon

    2011-01-01

    The third volume in the series Freud on Holiday describes a number of holiday possibilities, the problem of deciding where to go and when, the matters of cost and convenience, of appropriate companions and correct context. There are descriptions of train itineraries, of hotel rooms and restaurant menus, but the name of one restaurant resists recall for most of the book. There is a surprising connection with hysteria and another name is forgotten en route, accompanied by an embarrassing error ...

  3. Non Destructive Method for Biomass Prediction Combining TLS Derived Tree Volume and Wood Density

    Directory of Open Access Journals (Sweden)

    Jan Hackenberg

    2015-04-01

    Full Text Available This paper presents a method for predicting the above ground leafless biomass of trees in a non destructive way. We utilize terrestrial laserscan data to predict the volume of the trees. Combining volume estimates with density measurements leads to biomass predictions. Thirty-six trees of three different species are analyzed: evergreen coniferous Pinus massoniana, evergreen broadleaved Erythrophleum fordii and leafless deciduous Quercus petraea. All scans include a large number of noise points; denoising procedures are presented in detail. Density values are considered to be a minor source of error in the method if applied to stem segments, as comparison to ground truth data reveals that prediction errors for the tree volumes are in accordance with biomass prediction errors. While tree compartments with a diameter larger than 10 cm can be modeled accurately, smaller ones, especially twigs with a diameter smaller than 4 cm, are often largely overestimated. Better prediction results could be achieved by applying a biomass expansion factor to the biomass of compartments with a diameter larger than 10 cm. With this second method the average prediction error for Q. petraea could be reduced from 33.84% overestimation to 3.56%. E. fordii results could also be improved reducing the average prediction error from

  4. Solar Central Receiver Hybrid Power Systems sodium-cooled receiver concept. Final report. Volume III. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-01-01

    The overall, long term objective of the Solar Central Receiver Hybrid Power System is to identify, characterize, and ultimately demonstrate the viability and cost effectiveness of solar/fossil, steam Rankine cycle, hybrid power systems that: (1) consist of a combined solar central receiver energy source and a nonsolar energy source at a single, common site, (2) may operate in the base, intermediate, and peaking capacity modes, (3) produce the rated output independent of variations in solar insolation, (4) provide a significant savings (50% or more) in fuel consumpton, and (5) produce power at the minimum possible cost in mills/kWh. It is essential that these hybrid concepts be technically feasible and economically competitive with other systems in the near to mid-term time period (1985-1990) on a commercial scale. The program objective for Phase I is to identify and conceptually characterize solar/fossil steam Rankine cycle, commercial-scale, power plant systems that are economically viable and technically feasible. This volume contains appendices to the conceptual design and systems analysis studies gien in Volume II, Books 1 and 2. (WHK)

  5. Computational Methods for Protein Structure Prediction and Modeling Volume 1: Basic Characterization

    CERN Document Server

    Xu, Ying; Liang, Jie

    2007-01-01

    Volume one of this two volume sequence focuses on the basic characterization of known protein structures as well as structure prediction from protein sequence information. The 11 chapters provide an overview of the field, covering key topics in modeling, force fields, classification, computational methods, and struture prediction. Each chapter is a self contained review designed to cover (1) definition of the problem and an historical perspective, (2) mathematical or computational formulation of the problem, (3) computational methods and algorithms, (4) performance results, (5) existing software packages, and (6) strengths, pitfalls, challenges, and future research directions.

  6. Southwest Project: resource/institutional requirements analysis. Volume III. Systems integration studies

    Energy Technology Data Exchange (ETDEWEB)

    Ormsby, L. S.; Sawyer, T. G.; Brown, Dr., M. L.; Daviet, II, L. L; Weber, E. R.; Brown, J. E.; Arlidge, J. W.; Novak, H. R.; Sanesi, Norman; Klaiman, H. C.; Spangenberg, Jr., D. T.; Groves, D. J.; Maddox, J. D.; Hayslip, R. M.; Ijams, G.; Lacy, R. G.; Montgomery, J.; Carito, J. A.; Ballance, J. W.; Bluemle, C. F.; Smith, D. N.; Wehrey, M. C.; Ladd, K. L.; Evans, Dr., S. K.; Guild, D. H.; Brodfeld, B.; Cleveland, J. A.; Hicks, K. L.; Noga, M. W.; Ross, A. M.

    1979-12-01

    The purpose of this project is to provide information to DOE which can be used to establish its plans for accelerated commercialization and market penetration of solar electric generating plants in the southwestern region of the United States. The area of interest includes Arizona, California, Colorado, Nevada, New Mexico, Utah, and sections of Oklahoma and Texas. The system integration study establishes the investment that utilities could afford to make in solar thermal, photovoltaic, and wind energy systems, and to assess the sensitivity of the break-even cost to critical variables including fuel escalation rates, fixed charge rates, load growth rates, cloud cover, number of sites, load shape, and energy storage. This information will be used as input to Volume IV, Institutional Studies, one objective of which will be to determine the incentives required to close the gap between the break-even investment for the utilities of the Southwest and the estimated cost of solar generation.

  7. Solar Pilot Plant, Phase I. Preliminary design report. Volume III. Collector subsystem. CDRL item 2

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-05-01

    The Honeywell collector subsystem features a low-profile, multifaceted heliostat designed to provide high reflectivity and accurate angular and spatial positioning of the redirected solar energy under all conditions of wind load and mirror attitude within the design operational envelope. The heliostats are arranged in a circular field around a cavity receiver on a tower halfway south of the field center. A calibration array mounted on the receiver tower provides capability to measure individual heliostat beam location and energy periodically. This information and weather data from the collector field are transmitted to a computerized control subsystem that addresses the individual heliostat to correct pointing errors and determine when the mirrors need cleaning. This volume contains a detailed subsystem design description, a presentation of the design process, and the results of the SRE heliostat test program.

  8. Energy use in the marine transportation industry: Task II. Regulations and Tariffs. Final report, Volume III

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-12-01

    The evaluation of the energy impacts of regulations and tariffs is structured around three sequential steps: identification of agencies and organizations that impact the commercial marine transportation industry; identification of existing or proposed regulations that were perceived to have a significant energy impact; and quantification of the energy impacts. Following the introductory chapter, Chapter II describes the regulatory structure of the commercial marine transportation industry and includes a description of the role of each organization and the legislative basis for their jurisdiction and an identification of major areas of regulation and those areas that have an energy impact. Chapters III through IX each address one of the 7 existing or proposed regulatory or legislative actions that have an energy impact. Energy impacts of the state of Washington's tanker regulations, of tanker segregated ballast requirements, of inland waterway user charges, of cargo pooling and service rationalization, of the availability of intermodal container transportation services, of capacity limitations at lock and dam 26 on the Mississippi River and the energy implications of the transportation alternatives available for the West Coast crude oil supplies are discussed. (MCW)

  9. Predicting uncertainty in future marine ice sheet volume using Bayesian statistical methods

    Science.gov (United States)

    Davis, A. D.

    2015-12-01

    The marine ice instability can trigger rapid retreat of marine ice streams. Recent observations suggest that marine ice systems in West Antarctica have begun retreating. However, unknown ice dynamics, computationally intensive mathematical models, and uncertain parameters in these models make predicting retreat rate and ice volume difficult. In this work, we fuse current observational data with ice stream/shelf models to develop probabilistic predictions of future grounded ice sheet volume. Given observational data (e.g., thickness, surface elevation, and velocity) and a forward model that relates uncertain parameters (e.g., basal friction and basal topography) to these observations, we use a Bayesian framework to define a posterior distribution over the parameters. A stochastic predictive model then propagates uncertainties in these parameters to uncertainty in a particular quantity of interest (QoI)---here, the volume of grounded ice at a specified future time. While the Bayesian approach can in principle characterize the posterior predictive distribution of the QoI, the computational cost of both the forward and predictive models makes this effort prohibitively expensive. To tackle this challenge, we introduce a new Markov chain Monte Carlo method that constructs convergent approximations of the QoI target density in an online fashion, yielding accurate characterizations of future ice sheet volume at significantly reduced computational cost.Our second goal is to attribute uncertainty in these Bayesian predictions to uncertainties in particular parameters. Doing so can help target data collection, for the purpose of constraining the parameters that contribute most strongly to uncertainty in the future volume of grounded ice. For instance, smaller uncertainties in parameters to which the QoI is highly sensitive may account for more variability in the prediction than larger uncertainties in parameters to which the QoI is less sensitive. We use global sensitivity

  10. Class III β-tubulin in advanced NSCLC of adenocarcinoma subtype predicts superior outcome in a randomized trial

    DEFF Research Database (Denmark)

    Vilmar, Adam Christian; Santoni-Rugiu, Eric; Sørensen, Jens Benn

    2011-01-01

    Platinum-based doublets are the cornerstone of treatment in advanced non-small-cell lung cancer (NSCLC) and often include vinorelbine or taxanes. A predictive biomarker is greatly needed to select chemotherapy-sensitive patients for these microtubule-interfering agents. Class III ß-tubulin (TUBB3...

  11. Class III β-tubulin in advanced NSCLC of adenocarcinoma subtype predicts superior outcome in a randomized trial

    DEFF Research Database (Denmark)

    Vilmar, Adam Christian; Santoni-Rugiu, Eric; Sørensen, Jens Benn

    2011-01-01

    Platinum-based doublets are the cornerstone of treatment in advanced non-small-cell lung cancer (NSCLC) and often include vinorelbine or taxanes. A predictive biomarker is greatly needed to select chemotherapy-sensitive patients for these microtubule-interfering agents. Class III β-tubulin (TUBB3...

  12. Intratumoral Metabolic Heterogeneity for Prediction of Disease Progression After Concurrent Chemoradiotherapy in Patients with Inoperable Stage III Non-Small-Cell Lung Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Saeryung; Song, Hochun; Byun, Byung Hyun and others

    2014-03-15

    We evaluated the value of variable {sup 18}F-FDG PET/CT parameters for the prediction of disease progression after concurrent chemoradiotherapy (CCRT) in patients with inoperable stage III non-small-cell lung cancer (NSCLC). One hundred sixteen pretreatment FDG PET/CT scans of inoperable stage III NSCLC were retrospectively reviewed (stage IIIA: 51; stage IIIB: 65). The volume of interest was automatically drawn for each primary lung tumor, and PET parameters were assessed as follows: maximum standardized uptake value (SUV{sub max}), metabolic tumor volume (MTV) using the boundaries presenting SUV intensity exceeding 3.0, and the area under the curve of the cumulative SUV-volume histograms (AUC-CSH), which is known to reflect the tumor heterogeneity. Progression-free survival (PFS), locoregional recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) were compared with each PET and clinical parameters by univariate and multivariate survival analysis.In the ROC analysis, the optimal cutoff values of SUV{sub max}, MTV (cm{sup 3}), and AUC-CSH for prediction of PFS were determined as 21.5, 27.7, and 4,800, respectively. In univariate analysis, PFS was statistically significantly reduced in those with AUC-CSH<4,800 (p =0.004). In multivariate analysis, AUC-CSH and SUV{sub max} were statistically significant independent prognostic factors (HR 3.35, 95 % CI 1.79.6.28, p <0.001; HR 0.25, 95% CI 0.09.0.70, p =0.008, respectively). Multivariate analysis showed that AUC-CSH was the most significant independent prognostic factor for LRFS and DMFS (HR 3.27, 95 % CI 1.54.6.94, p =0.002; HR 2.79, 95 % CI 1.42.5.50, p =0.003). Intratumoral metabolic heterogeneity of primary lung tumor in {sup 18}F-FDG PET/CT can predict disease progression after CCRT in inoperable stage III NSCLC.

  13. OTEC modular experiment cold water pipe concept evaluation. Volume III. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    1979-04-01

    The Cold Water Pipe System Design Study was undertaken to evaluate the diverse CWP concepts, recommend the most viable alternatives for a 1984 deployment of the 10 to 40 MWe MEP, and carry out preliminary designs of three concepts. The concept evaluation phase reported involved a systems analysis of design alternatives in the broad categories of rigid walled (with hinges), compliant walled, stockade and bottom mounted buoyant. Quantitative evaluations were made of concept performance, availability, deployment schedule, technical feasibility and cost. CWP concepts were analyzed to determine if they met or could be made to meet established system requirements and could be deployed by 1984. Fabrication, construction and installation plans were developed for successful concepts, and costs were determined in a WBS format. Evaluations were performed on the basis of technical and cost risk. This volume includes the following appendices: (A) materials and associated design criteria; (B) summary of results of dynamic flow and transportation analysis; (C) CWP sizing analysis; (D) CWP thermal performance; and (E) investigation of the APL/ABAM CWP design. (WHK)

  14. Sensitivity Analysis of Wavelet Neural Network Model for Short-Term Traffic Volume Prediction

    Directory of Open Access Journals (Sweden)

    Jinxing Shen

    2013-01-01

    Full Text Available In order to achieve a more accurate and robust traffic volume prediction model, the sensitivity of wavelet neural network model (WNNM is analyzed in this study. Based on real loop detector data which is provided by traffic police detachment of Maanshan, WNNM is discussed with different numbers of input neurons, different number of hidden neurons, and traffic volume for different time intervals. The test results show that the performance of WNNM depends heavily on network parameters and time interval of traffic volume. In addition, the WNNM with 4 input neurons and 6 hidden neurons is the optimal predictor with more accuracy, stability, and adaptability. At the same time, a much better prediction record will be achieved with the time interval of traffic volume are 15 minutes. In addition, the optimized WNNM is compared with the widely used back-propagation neural network (BPNN. The comparison results indicated that WNNM produce much lower values of MAE, MAPE, and VAPE than BPNN, which proves that WNNM performs better on short-term traffic volume prediction.

  15. Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed

    DEFF Research Database (Denmark)

    Posthuma, Daniëlle; Baare, Wim F.C.; Hulshoff Pol, Hilleke E.;

    2003-01-01

    to cerebellar volume. Verbal Comprehension was not related to any of the three brain volumes. It is concluded that brain volumes are genetically related to intelligence which suggests that genes that influence brain volume may also be important for intelligence. It is also noted however, that the direction......We recently showed that the correlation of gray and white matter volume with full scale IQ and the Working Memory dimension are completely mediated by common genetic factors (Posthuma et al., 2002). Here we examine whether the other WAIS III dimensions (Verbal Comprehension, Perceptual Organization...... to Working Memory capacity (r = 0.27). This phenotypic correlation is completely due to a common underlying genetic factor. Processing Speed was genetically related to white matter volume (r(g) = 0.39). Perceptual Organization was both genetically (r(g) = 0.39) and environmentally (r(e) = -0.71) related...

  16. A prediction model of radiation-induced necrosis for intracranial radiosurgery based on target volume.

    Science.gov (United States)

    Zhao, Bo; Wen, Ning; Chetty, Indrin J; Huang, Yimei; Brown, Stephen L; Snyder, Karen C; Siddiqui, Farzan; Movsas, Benjamin; Siddiqui, M Salim

    2017-08-01

    This study aims to extend the observation that the 12 Gy-radiosurgical-volume (V12Gy) correlates with the incidence of radiation necrosis in patients with intracranial tumors treated with radiosurgery by using target volume to predict V12Gy. V12Gy based on the target volume was used to predict the radiation necrosis probability (P) directly. Also investigated was the reduction in radiation necrosis rates (ΔP) as a result of optimizing the prescription isodose lines for linac-based SRS. Twenty concentric spherical targets and 22 patients with brain tumors were retrospectively studied. For each case, a standard clinical plan and an optimized plan with prescription isodose lines based on gradient index were created. V12Gy were extracted from both plans to analyze the correlation between V12Gy and target volume. The necrosis probability P as a function of V12Gy was evaluated. To account for variation in prescription, the relation between V12Gy and prescription was also investigated. A prediction model for radiation-induced necrosis was presented based on the retrospective study. The model directly relates the typical prescribed dose and the target volume to the radionecrosis probability; V12Gy increased linearly with the target volume (R(2)  > 0.99). The linear correlation was then integrated into a logistic model to predict P directly from the target volume. The change in V12Gy as a function of prescription was modeled using a single parameter, s (=-1.15). Relatively large ΔP was observed for target volumes between 7 and 28 cm(3) with the maximum reduction (8-9%) occurring at approximately 18 cm(3) . Based on the model results, optimizing the prescription isodose line for target volumes between 7 and 28 cm(3) results in a significant reduction in necrosis probability. V12Gy based on the target volume could provide clinicians a predictor of radiation necrosis at the contouring stage thus facilitating treatment decisions. © 2017 American Association of

  17. Predicting Pattern Tooling and Casting Dimensions for Investment Casting, Phase III

    Energy Technology Data Exchange (ETDEWEB)

    Sabau, Adrian S [ORNL

    2008-04-01

    Efforts during Phase III focused mainly on the shell-alloy systems. A high melting point alloy, 17-4PH stainless steel, was considered. The experimental part of the program was conducted at ORNL and commercial foundries, where wax patterns were injected, molds were invested, and alloys were poured. Shell molds made of fused-silica and alumino-silicates were considered. A literature review was conducted on thermophysical and thermomechanical properties alumino-silicates. Material property data, which were not available from material suppliers, was obtained. For all the properties of 17-4PH stainless steel, the experimental data available in the literature did not cover the entire temperature range necessary for process simulation. Thus, some material properties were evaluated using ProCAST, based on CompuTherm database. A comparison between the predicted material property data and measured property data was made. It was found that most material properties were accurately predicted only over several temperature ranges. No experimental data for plastic modulus were found. Thus, several assumptions were made and ProCAST recommendations were followed in order to obtain a complete set of mechanical property data at high temperatures. Thermal expansion measurements for the 17-4PH alloy were conducted during heating and cooling. As a function of temperature, the thermal expansion for both the alloy and shell mold materials showed different evolution on heating and cooling. Numerical simulations were performed using ProCAST for the investment casting of 17-4PH stainless steel parts in fused silica molds using the thermal expansion obtained on heating and another one with thermal expansion obtained on cooling. Since the fused silica shells had the lowest thermal expansion properties in the industry, the dewaxing phase, including the coupling between wax-shell systems, was neglected. The shell mold was considered to be a pure elastic material. The alloy dimensions were

  18. Anterior cingulate volume predicts response to cognitive behavioral therapy in major depressive disorder.

    Science.gov (United States)

    Fujino, Junya; Yamasaki, Nobuyuki; Miyata, Jun; Sasaki, Hitoshi; Matsukawa, Noriko; Takemura, Ariyoshi; Tei, Shisei; Sugihara, Genichi; Aso, Toshihiko; Fukuyama, Hidenao; Takahashi, Hidehiko; Inoue, Kazuomi; Murai, Toshiya

    2015-03-15

    Cognitive behavioral therapy (CBT) is widely used to treat major depressive disorder (MDD). Although improved response prediction could facilitate the development of individualized treatment plans, few studies have investigated whether underlying brain structure is related to CBT response in MDD. Ten MDD patients who received individual CBT were studied in this study. We investigated the relationship between the regional gray matter (GM) volume and subsequent responses to CBT using voxel-based morphometry. The degree of improvement in depressive symptoms was positively correlated with GM volume in the caudal portion of the anterior cingulate cortex. The sample size was small, and the effects of medication on the results could not be excluded. Our results, although preliminary, suggest that the anterior cingulate cortex is a key structure whose volume can be used to predict responses to CBT and is thus a potential prognostic marker in MDD. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Age-associated losses of brain volume predict longitudinal cognitive declines over 8 to 20 years.

    Science.gov (United States)

    Rabbitt, Patrick; Ibrahim, Said; Lunn, Mary; Scott, Marietta; Thacker, Neil; Hutchinson, Charles; Horan, Michael; Pendleton, Neil; Jackson, Alan

    2008-01-01

    Absolute differences in global brain volume predict differences in cognitive ability among healthy older adults. However, absolute differences confound lifelong differences in brain size with amounts of age-related shrinkage. Measurements of cerebrospinal fluid (CSF) volume were made to estimate age-related shrinkage in 93 healthy volunteers aged 63 to 86 years. Their current levels of brain shrinkage predicted their amounts of decline over the previous 8 to 20 years on repeated assessments during a longitudinal study on the Cattell "Culture Fair" Intelligence Test, on two tests of information processing speed, and marginally on the Wechsler Adult Intelligence Scale (D. Wechsler, 1981), but not on three memory tests. Loss of brain volume is an effective marker both for current cognitive status and for amounts and rates of previous age-related cognitive losses.

  20. Prediction of sonic boom from experimental near-field overpressure data. Volume 2: Data base construction

    Science.gov (United States)

    Glatt, C. R.; Reiners, S. J.; Hague, D. S.

    1975-01-01

    A computerized method for storing, updating and augmenting experimentally determined overpressure signatures has been developed. A data base of pressure signatures for a shuttle type vehicle has been stored. The data base has been used for the prediction of sonic boom with the program described in Volume I.

  1. PREDICTION OF THE MIXING ENTHALPIES OF BINARY LIQUID ALLOYS BY MOLECULAR INTERACTION VOLUME MODEL

    Institute of Scientific and Technical Information of China (English)

    H.W.Yang; D.P.Tao; Z.H.Zhou

    2008-01-01

    The mixing enthalpies of 23 binary liquid alloys are calculated by molecular interaction volume model (MIVM), which is a two-parameter model with the partial molar infinite dilute mixing enthalpies. The predicted values are in agreement with the experimental data and then indicate that the model is reliable and convenient.

  2. Is it possible to predict low-volume and insignificant prostate cancer by core needle biopsies?

    DEFF Research Database (Denmark)

    Berg, Kasper Drimer; Toft, Birgitte Grønkaer; Røder, Martin Andreas;

    2013-01-01

    M: tumour ≤5% of total prostate volume and prostate-specific antigen (PSA) ≤10 ng/mL. In all definitions, Gleason score (GS) was ≤6 and the tumour was organ confined. Biopsies alone performed poorly as a predictor of unifocal and unilateral cancer in the prostatectomy specimens with positive predictive...

  3. Establishment of a biomarker model for predicting bone metastasis in resected stage III non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Zhou Zhen

    2012-04-01

    Full Text Available Abstract Background This study was designed to establish a biomarker risk model for predicting bone metastasis in stage III non-small cell lung cancer (NSCLC. Methods The model consists of 105 cases of stage III NSCLC, who were treated and followed up. The patients were divided into bone metastasis group (n = 45 and non-bone metastasis group (other visceral metastasis and those without recurrence (n = 60. Tissue microarrays were constructed for immunohistochemical study of 10 molecular markers associated with bone metastasis, based on which a model was established via logistic regression analysis for predicting the risk of bone metastases. The model was prospectively validated in another 40 patients with stage III NSCLC. Results The molecular model for predicting bone metastasis was logit (P = − 2.538 + 2.808 CXCR4 +1.629 BSP +0.846 OPN-2.939 BMP4. ROC test showed that when P ≥ 0.408, the sensitivity was up to 71% and specificity of 70%. Model validation in the 40 cases in clinical trial (NCT 01124253 demonstrated that the prediction sensitivity of the model was 85.7%, specificity 66.7%, Kappa: 0.618, with a high degree of consistency. Conclusion The molecular model combining CXCR4, BSP, OPN and BMP4 could help predict the risk of bone metastasis in stage IIIa and IIIb resected NSCLC.

  4. Applications of Displacement Transfer Functions to Deformed Shape Predictions of the G-III Swept-Wing Structure

    Science.gov (United States)

    Lung, Shun-Fat; Ko, William L.

    2016-01-01

    In support of the Adaptive Compliant Trailing Edge [ACTE] project at the NASA Armstrong Flight Research Center, displacement transfer functions were applied to the swept wing of a Gulfstream G-III airplane (Gulfstream Aerospace Corporation, Savannah, Georgia) to obtain deformed shape predictions. Four strainsensing lines (two on the lower surface, two on the upper surface) were used to calculate the deformed shape of the G III wing under bending and torsion. There being an insufficient number of surface strain sensors, the existing G III wing box finite element model was used to generate simulated surface strains for input to the displacement transfer functions. The resulting predicted deflections have good correlation with the finite-element generated deflections as well as the measured deflections from the ground load calibration test. The convergence study showed that the displacement prediction error at the G III wing tip can be reduced by increasing the number of strain stations (for each strain-sensing line) down to a minimum error of l.6 percent at 17 strain stations; using more than 17 strain stations yielded no benefit because the error slightly increased to 1.9% when 32 strain stations were used.

  5. Infarct volume predicts critical care needs in stroke patients treated with intravenous thrombolysis

    Energy Technology Data Exchange (ETDEWEB)

    Faigle, Roland; Marsh, Elisabeth B.; Llinas, Rafael H.; Urrutia, Victor C. [Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD (United States); Wozniak, Amy W. [Johns Hopkins University, Department of Biostatistics, Bloomberg School of Public Health, Baltimore, MD (United States)

    2014-10-26

    Patients receiving intravenous thrombolysis with recombinant tissue plasminogen activator (IVT) for ischemic stroke are monitored in an intensive care unit (ICU) or a comparable unit capable of ICU interventions due to the high frequency of standardized neurological exams and vital sign checks. The present study evaluates quantitative infarct volume on early post-IVT MRI as a predictor of critical care needs and aims to identify patients who may not require resource intense monitoring. We identified 46 patients who underwent MRI within 6 h of IVT. Infarct volume was measured using semiautomated software. Logistic regression and receiver operating characteristics (ROC) analysis were used to determine factors associated with ICU needs. Infarct volume was an independent predictor of ICU need after adjusting for age, sex, race, systolic blood pressure, NIH Stroke Scale (NIHSS), and coronary artery disease (odds ratio 1.031 per cm{sup 3} increase in volume, 95 % confidence interval [CI] 1.004-1.058, p = 0.024). The ROC curve with infarct volume alone achieved an area under the curve (AUC) of 0.766 (95 % CI 0.605-0.927), while the AUC was 0.906 (95 % CI 0.814-0.998) after adjusting for race, systolic blood pressure, and NIHSS. Maximum Youden index calculations identified an optimal infarct volume cut point of 6.8 cm{sup 3} (sensitivity 75.0 %, specificity 76.7 %). Infarct volume greater than 3 cm{sup 3} predicted need for critical care interventions with 81.3 % sensitivity and 66.7 % specificity. Infarct volume may predict needs for ICU monitoring and interventions in stroke patients treated with IVT. (orig.)

  6. Subsonic Ultra Green Aircraft Research: Phase II- Volume III-Truss Braced Wing Aeroelastic Test Report

    Science.gov (United States)

    Bradley, Marty K.; Allen, Timothy J.; Droney, Christopher

    2014-01-01

    This Test Report summarizes the Truss Braced Wing (TBW) Aeroelastic Test (Task 3.1) work accomplished by the Boeing Subsonic Ultra Green Aircraft Research (SUGAR) team, which includes the time period of February 2012 through June 2014. The team consisted of Boeing Research and Technology, Boeing Commercial Airplanes, Virginia Tech, and NextGen Aeronautics. The model was fabricated by NextGen Aeronautics and designed to meet dynamically scaled requirements from the sized full scale TBW FEM. The test of the dynamically scaled SUGAR TBW half model was broken up into open loop testing in December 2013 and closed loop testing from January 2014 to April 2014. Results showed the flutter mechanism to primarily be a coalescence of 2nd bending mode and 1st torsion mode around 10 Hz, as predicted by analysis. Results also showed significant change in flutter speed as angle of attack was varied. This nonlinear behavior can be explained by including preload and large displacement changes to the structural stiffness and mass matrices in the flutter analysis. Control laws derived from both test system ID and FEM19 state space models were successful in suppressing flutter. The control laws were robust and suppressed flutter for a variety of Mach, dynamic pressures, and angle of attacks investigated.

  7. Review of methods for predicting in situ volume change movement of expansive soil over time

    Directory of Open Access Journals (Sweden)

    Hana H. Adem

    2015-02-01

    Full Text Available The soil movement information over time is required for the design of foundations placed in expansive soils. This information is also helpful for the assessment of pre-wetting and controlled wetting mitigation alternatives for expansive soils. Several researchers during the past fifteen years have proposed different methods for the prediction of the soil movements over time. The available methods can be categorized into (i consolidation theory-based methods, (ii water content-based methods, and (iii suction-based methods. In this paper, a state-of-the-art of the prediction methods is succinctly summarized. The methods are critically reviewed in terms of their predictive capacity along with their strengths and limitations. The review highlights the need for prediction methods that are conceptually simple yet efficient for use in conventional engineering practice for different types of expansive soils.

  8. Review of methods for predicting in situ volume change movement of expansive soil over time

    Institute of Scientific and Technical Information of China (English)

    Hana H. Adem; Sai K. Vanapalli

    2015-01-01

    The soil movement information over time is required for the design of foundations placed in expansive soils. This information is also helpful for the assessment of pre-wetting and controlled wetting mitigation alternatives for expansive soils. Several researchers during the past fifteen years have proposed different methods for the prediction of the soil movements over time. The available methods can be categorized into (i) consolidation theory-based methods, (ii) water content-based methods, and (iii) suction-based methods. In this paper, a state-of-the-art of the prediction methods is succinctly summarized. The methods are critically reviewed in terms of their predictive capacity along with their strengths and limitations. The review highlights the need for prediction methods that are conceptually simple yet efficient for use in conventional engineering practice for different types of expansive soils.

  9. Performance Prediction Modelling for Flexible Pavement on Low Volume Roads Using Multiple Linear Regression Analysis

    Directory of Open Access Journals (Sweden)

    C. Makendran

    2015-01-01

    Full Text Available Prediction models for low volume village roads in India are developed to evaluate the progression of different types of distress such as roughness, cracking, and potholes. Even though the Government of India is investing huge quantum of money on road construction every year, poor control over the quality of road construction and its subsequent maintenance is leading to the faster road deterioration. In this regard, it is essential that scientific maintenance procedures are to be evolved on the basis of performance of low volume flexible pavements. Considering the above, an attempt has been made in this research endeavor to develop prediction models to understand the progression of roughness, cracking, and potholes in flexible pavements exposed to least or nil routine maintenance. Distress data were collected from the low volume rural roads covering about 173 stretches spread across Tamil Nadu state in India. Based on the above collected data, distress prediction models have been developed using multiple linear regression analysis. Further, the models have been validated using independent field data. It can be concluded that the models developed in this study can serve as useful tools for the practicing engineers maintaining flexible pavements on low volume roads.

  10. Brain volume reduction predicts weight development in adolescent patients with anorexia nervosa.

    Science.gov (United States)

    Seitz, Jochen; Walter, Martin; Mainz, Verena; Herpertz-Dahlmann, Beate; Konrad, Kerstin; von Polier, Georg

    2015-09-01

    Acute anorexia nervosa (AN) is associated with marked brain volume loss potentially leading to neuropsychological deficits. However, the mechanisms leading to this brain volume loss and its influencing factors are poorly understood and the clinical relevance of these brain alterations for the outcome of these AN-patients is yet unknown. Brain volumes of 56 female adolescent AN inpatients and 50 healthy controls (HCs) were measured using MRI scans. Multiple linear regression analyses were used to determine the impact of body weight at admission, prior weight loss, age of onset and illness duration on volume loss at admission and to analyse the association of brain volume reduction with body weight at a 1-year follow-up (N = 25). Cortical and subcortical grey matter (GM) and cortical white matter (WM) but not cerebellar GM or WM were associated with low weight at admission. Amount of weight loss, age of onset and illness duration did not independently correlate with any volume changes. Prediction of age-adjusted standardized body mass index (BMI-SDS) at 1-year follow-up could be significantly improved from 34% of variance explained by age and BMI-SDS at admission to 47.5-53% after adding cortical WM, cerebellar GM or WM at time of admission. Whereas cortical GM changes appear to be an unspecific reflection of current body weight ("state marker"), cortical WM and cerebellar volume losses seem to indicate a longer-term risk (trait or "scar" of the illness), which appear to be important for the prediction of weight rehabilitation and long-term outcome. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Prediction of volume fractions in three-phase flows using nuclear technique and artificial neural network

    Energy Technology Data Exchange (ETDEWEB)

    Marques Salgado, Cesar [Instituto de Engenharia Nuclear, DIRA/IEN/CNEN, Rio de Janeiro, CEP.: 21945-970-Caixa Postal 68550 (Brazil)], E-mail: otero@ien.gov.br; Brandao, Luis E.B. [Instituto de Engenharia Nuclear, DIRA/IEN/CNEN, Rio de Janeiro, CEP.: 21945-970-Caixa Postal 68550 (Brazil); Schirru, Roberto [Universidade Federal do Rio de Janeiro, PEN/COPPE-DNC/EE-CT, Rio de Janeiro, CEP.: 21941-972-Caixa Postal 68509 (Brazil); Pereira, Claudio M.N.A. [Instituto de Engenharia Nuclear, DIRA/IEN/CNEN, Rio de Janeiro, CEP.: 21945-970-Caixa Postal 68550 (Brazil); Silva, Ademir Xavier da [Universidade Federal do Rio de Janeiro, PEN/COPPE-DNC/EE-CT, Rio de Janeiro, CEP.: 21941-972-Caixa Postal 68509 (Brazil); Ramos, Robson [Instituto de Engenharia Nuclear, DIRA/IEN/CNEN, Rio de Janeiro, CEP.: 21945-970-Caixa Postal 68550 (Brazil)

    2009-10-15

    This work presents methodology based on nuclear technique and artificial neural network for volume fraction predictions in annular, stratified and homogeneous oil-water-gas regimes. Using principles of gamma-ray absorption and scattering together with an appropriate geometry, comprised of three detectors and a dual-energy gamma-ray source, it was possible to obtain data, which could be adequately correlated to the volume fractions of each phase by means of neural network. The MCNP-X code was used in order to provide the training data for the network.

  12. A predictive nondestructive model for the covariation of tree height, diameter, and stem volume scaling relationships

    Science.gov (United States)

    Zhang, Zhongrui; Zhong, Quanlin; Niklas, Karl J.; Cai, Liang; Yang, Yusheng; Cheng, Dongliang

    2016-08-01

    Metabolic scaling theory (MST) posits that the scaling exponents among plant height H, diameter D, and biomass M will covary across phyletically diverse species. However, the relationships between scaling exponents and normalization constants remain unclear. Therefore, we developed a predictive model for the covariation of H, D, and stem volume V scaling relationships and used data from Chinese fir (Cunninghamia lanceolata) in Jiangxi province, China to test it. As predicted by the model and supported by the data, normalization constants are positively correlated with their associated scaling exponents for D vs. V and H vs. V, whereas normalization constants are negatively correlated with the scaling exponents of H vs. D. The prediction model also yielded reliable estimations of V (mean absolute percentage error = 10.5 ± 0.32 SE across 12 model calibrated sites). These results (1) support a totally new covariation scaling model, (2) indicate that differences in stem volume scaling relationships at the intra-specific level are driven by anatomical or ecophysiological responses to site quality and/or management practices, and (3) provide an accurate non-destructive method for predicting Chinese fir stem volume.

  13. A predictive nondestructive model for the covariation of tree height, diameter, and stem volume scaling relationships.

    Science.gov (United States)

    Zhang, Zhongrui; Zhong, Quanlin; Niklas, Karl J; Cai, Liang; Yang, Yusheng; Cheng, Dongliang

    2016-08-24

    Metabolic scaling theory (MST) posits that the scaling exponents among plant height H, diameter D, and biomass M will covary across phyletically diverse species. However, the relationships between scaling exponents and normalization constants remain unclear. Therefore, we developed a predictive model for the covariation of H, D, and stem volume V scaling relationships and used data from Chinese fir (Cunninghamia lanceolata) in Jiangxi province, China to test it. As predicted by the model and supported by the data, normalization constants are positively correlated with their associated scaling exponents for D vs. V and H vs. V, whereas normalization constants are negatively correlated with the scaling exponents of H vs. D. The prediction model also yielded reliable estimations of V (mean absolute percentage error = 10.5 ± 0.32 SE across 12 model calibrated sites). These results (1) support a totally new covariation scaling model, (2) indicate that differences in stem volume scaling relationships at the intra-specific level are driven by anatomical or ecophysiological responses to site quality and/or management practices, and (3) provide an accurate non-destructive method for predicting Chinese fir stem volume.

  14. 3D quantification of microclimate volume in layered clothing for the prediction of clothing insulation.

    Science.gov (United States)

    Lee, Yejin; Hong, Kyunghi; Hong, Sung-Ae

    2007-05-01

    Garment fit and resultant air volume is a crucial factor in thermal insulation, and yet, it has been difficult to quantify the air volume of clothing microclimate and relate it to the thermal insulation value just using the information on the size of clothing pattern without actual 3D volume measurement in wear condition. As earlier methods for the computation of air volume in clothing microclimate, vacuum over suit and circumference model have been used. However, these methods have inevitable disadvantages in terms of cost or accuracy due to the limitations of measurement equipment. In this paper, the phase-shifting moiré topography was introduced as one of the 3D scanning tools to measure the air volume of clothing microclimate quantitatively. The purpose of this research is to adopt a non-contact image scanning technology, phase-shifting moiré topography, to ascertain relationship between air volume and insulation value of layered clothing systems in wear situations where the 2D fabric creates new conditions in 3D spaces. The insulation of vests over shirts as a layered clothing system was measured with a thermal manikin in the environmental condition of 20 degrees C, 65% RH and air velocity of 0.79 m/s. As the pattern size increased, the insulation of the clothing system was increased. But beyond a certain limit, the insulation started to decrease due to convection and ventilation, which is more apparent when only the vest was worn over the torso of manikin. The relationship between clothing air volume and insulation was difficult to predict with a single vest due to the extreme openings which induced active ventilation. But when the vest was worn over the shirt, the effects of thickness of the fabrics on insulation were less pronounced compared with that of air volume. In conclusion, phase-shifting moiré topography was one of the efficient and accurate ways of quantifying air volume and its distribution across the clothing microclimate. It is also noted

  15. NCEP-ATP III and IDF criteria for metabolic syndrome predict type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Eva Sulistiowati

    2016-05-01

    Full Text Available Background Subjects with metabolic syndrome (MetS have a greater risk for acquiring type 2 diabetes mellitus (type 2 DM. The MetS criteria usually used are those of the National Cholesterol Education Program Expert Panel (NCEP and Adult Treatment Panel III (ATP III and of the International Diabetes Federation (IDF. This study aimed to evaluate the modified NCEP-ATP III and IDF criteria as predictor of type 2 DM among subjects with MetS.   Methods A cohort study was conducted among 4240 subjects with MetS. MetS was determined according to the modified NCEP-ATP III and IDF criteria. The study followed up 3324 non-diabetic subjects of the cohort study of non-communicable disease (NCD risk factors (NCD study during a 2-year period. Type 2 DM was determined from the diagnosis by health personnel or from fasting blood glucose of ≥126 mg/dL or blood glucose of ≥200 mg/dL, 2 hours after 75g glucose loading.   Results The MetS prevalence based on modified NCEP ATP III and IDF criteria in non-DM subjects was 17.1% and 15.6%, respectively. The risk for DM in subjects with MetS using modified NCEP ATP III and IDF criteria was 4.7 (CI 95%: 3.4-6.5 and 4.1 (CI 95%: 3.0-5.7, respectively.   Conclusions Both MetS criteria can be used as predictors of the occurrence of DM type 2, but the modified NCEP-ATP III is more properly applied than the IDF criteria in subjects with MetS. Screening programs and routine monitoring of MetS components are required for early detection of type 2 DM.

  16. Sonographic Parameters for Prediction of Miscarriage: Role of 3-Dimensional Volume Measurement.

    Science.gov (United States)

    Wie, Jeong Ha; Choe, Suyearn; Kim, Sa Jin; Shin, Jong Chul; Kwon, Ji Young; Park, In Yang

    2015-10-01

    To evaluate the value of volume measurement using 3-dimensional sonography for prediction of miscarriage. We prospectively enrolled 188 singleton pregnant women at 5 to 9 weeks' gestation. The 3-dimensional sonographic gestational sac volume and yolk sac volume were measured together with the fetal heart rate, gestational sac diameter, and yolk sac diameter. For each sonographic parameter, nomograms were created; z scores were calculated for each measurement, and the values were compared between miscarriage and ongoing pregnancy groups. Sonographic parameters for prediction of miscarriage were evaluated by multivariate analysis, and the screening performance was assessed by a receiver operating characteristic curve. Among the 188 pregnancies, 30 (16.0%) had miscarriage. Multivariate analysis showed that fetal heart rate below the 5th percentile (odds ratio, 6.43), gestational sac diameter below the 5th percentile (odds ratio, 4.87), gestational sac volume below the 5th percentile (odds ratio, 5.25), and yolk sac diameter below the 2.5th or above the 97.5th percentile (odds ratio, 15.86) were significant predictors of miscarriage (P = .018; P = .018; P = .033; and P < .001, respectively). At a false-positive rate of 30%, the detection rate for miscarriage in screening by a combination of fetal heart rate, gestational sac diameter, gestational sac volume, and yolk sac diameter was 77.8%. A small-for-gestational-age gestational sac volume is a significant sonographic predictor of miscarriage, as are fetal bradycardia, a small gestational sac diameter, and a small or large yolk sac diameter. © 2015 by the American Institute of Ultrasound in Medicine.

  17. Generalized nonlinear models applied to the prediction of basal area and volume of Eucalyptus sp

    Directory of Open Access Journals (Sweden)

    Samuel de Pádua Chaves e Carvalho

    2011-12-01

    Full Text Available This paper aims to propose the use of generalized nonlinear models for prediction of basal area growth and yield of total volume of the hybrid Eucalyptus urocamaldulensis, in a stand situation in a central region in state of Minas Gerais. The used methodology allows to work with data in its original form without the necessity of transformation of variables, and generate highly accurate models. To evaluate the fitting quality, it was proposed the Bayesian information criterion, of the Akaike, and test the maximum likelihood, beyond the standard error of estimate, and residual graphics. The models were used with a good performance, highly accurate and parsimonious estimates of the variables proposed, with errors reduced to 12% for basal area and 4% for prediction of the volume.

  18. Prediction total specific pore volume of geopolymers produced from waste ashes by fuzzy logic

    Directory of Open Access Journals (Sweden)

    Ali Nazari

    2012-04-01

    Full Text Available In the present work, total specific pore volume of inorganic polymers (geopolymers made from seeded fly ash and rice husk bark ash has been predicted by fuzzy logic. Different specimens, made from a mixture of fly ash and rice husk bark ash in fine and coarse form together with alkali activator made of water glass and NaOH solution, were subjected to porosimetry tests at 7 and 28 days of curing. The curing regime was different: one set of the specimens were cured at room temperature until reaching to 7 and 28 days and the other sets were oven cured for 36 hours at the range of 40-90 °C and then cured at room temperature until 7 and 28 days. A model based on fuzzy logic for predicting the total specific pore volume of the specimens has been presented. To build the model, training and testing using experimental results from 120 specimens were conducted. The used data as the inputs of fuzzy logic models are arranged in a format of six parameters that cover the percentage of fine fly ash in the ashes mixture, the percentage of coarse fly ash in the ashes mixture, the percentage of fine rice husk bark ash in the ashes mixture, the percentage of coarse rice husk bark ash in the ashes mixture, the temperature of curing and the time of water curing. According to the input parameters, in the fuzzy logic model, the pore volume of each specimen was predicted. The training and testing results in the fuzzy logic model have shown a strong potential for predicting the total specific pore volume of the geopolymer specimens in the considered range.

  19. Long-term results of preventive embolization of renal angiomyolipomas: evaluation of predictive factors of volume decrease

    Energy Technology Data Exchange (ETDEWEB)

    Hocquelet, A.; Cornelis, F.; Le Bras, Y.; Meyer, M.; Tricaud, E.; Lasserre, A.S.; Grenier, N. [Centre Hospitalier Universitaire Pellegrin, Diagnostic and Therapeutic Urology and Vascular Imaging, Bordeaux (France); Ferriere, J.M.; Robert, G. [Centre Hospitalier Universitaire Pellegrin, Urology Service, Bordeaux (France)

    2014-08-15

    To evaluate the efficacy of selective arterial embolization (SAE) of angiomyolipomas based on the percentage volume reduction after embolization and to identify predictive factors of volume decrease. Patients receiving prophylactic SAE of renal angiomyolipomas were included retrospectively over 3 years. The volume change after SAE and haemorrhagic or surgical events were recorded. Initial tumour volume, percentage tumour fat content, mean tumour density, embolic agent used, number of angiomyolipomas and tuberous sclerosis disease were evaluated as predictive factors of volume decrease. A total of 19 patients with 39 angiomyolipomas were included with median follow-up of 28 months (interquartile range 21-37 months). All treatments were technically successful (92 % primary and 8 % secondary). No distal bleeding or any increase in size or surgical nephrectomy after SAE was recorded. Mean volume reduction was 72 % (±24 %). Volumes before SAE (R{sup 2} = 0.276; p = 0.001), percentage fat content (R{sup 2} = 0.612; p < 0.0001) and mean angiomyolipoma density (R{sup 2} = 0.536; p < 0.0001) were identified as predictive factors of volume decrease. In multivariate regression, only percentage fat content influenced volume decreases. SAE is an efficient treatment for angiomyolipoma devascularisation and volume reduction. A significant reduction of volume is modulated by the initial volume and tissue composition of the tumour. (orig.)

  20. Data fusion for planning target volume and isodose prediction in prostate brachytherapy

    Science.gov (United States)

    Nouranian, Saman; Ramezani, Mahdi; Mahdavi, S. Sara; Spadinger, Ingrid; Morris, William J.; Salcudean, Septimiu E.; Abolmaesumi, Purang

    2015-03-01

    In low-dose prostate brachytherapy treatment, a large number of radioactive seeds is implanted in and adjacent to the prostate gland. Planning of this treatment involves the determination of a Planning Target Volume (PTV), followed by defining the optimal number of seeds, needles and their coordinates for implantation. The two major planning tasks, i.e. PTV determination and seed definition, are associated with inter- and intra-expert variability. Moreover, since these two steps are performed in sequence, the variability is accumulated in the overall treatment plan. In this paper, we introduce a model based on a data fusion technique that enables joint determination of PTV and the minimum Prescribed Isodose (mPD) map. The model captures the correlation between different information modalities consisting of transrectal ultrasound (TRUS) volumes, PTV and isodose contours. We take advantage of joint Independent Component Analysis (jICA) as a linear decomposition technique to obtain a set of joint components that optimally describe such correlation. We perform a component stability analysis to generate a model with stable parameters that predicts the PTV and isodose contours solely based on a new patient TRUS volume. We propose a framework for both modeling and prediction processes and evaluate it on a dataset of 60 brachytherapy treatment records. We show PTV prediction error of 10:02+/-4:5% and the V100 isodose overlap of 97+/-3:55% with respect to the clinical gold standard.

  1. Predicting scores of the Halstead Category Test with the WAIS-III.

    Science.gov (United States)

    Titus, Jeffrey B; Retzlaff, Paul D; Dean, Raymond S

    2002-09-01

    The Halstead Category Test (HCT) and the Wechsler Adult Intelligence Scale (WAIS) are two of the most widely used neuropsychological tests. Often assessment conclusions are dependent upon the comparison of these measures. Therefore, it is crucial for clinicians to know how they relate to one another. This study examined the relationship between the HCT and the WAIS-III with undergraduate psychology students. Correlational analyses were conducted between HCT scores and WAIS-III subtests, Verbal and Performance IQ, and Full Scale IQ scores. Additionally, the new WAIS-III scales (Letter-Number Sequencing, Matrix Reasoning, and Symbol Search) were further examined. Regression analyses were run to develop predictor equations for the HCT using VIQ, PIQ, and FSIQ. Finally, predictor tables were generated between the HCT and VIQ, PIQ, and FSIQ to provide assessment of brain dysfunction for clinical use.

  2. Black liquor combustion validated recovery boiler modeling: Final year report. Volume 3 (Appendices II, sections 2--3 and III)

    Energy Technology Data Exchange (ETDEWEB)

    Grace, T.M.; Frederick, W.J.; Salcudean, M.; Wessel, R.A.

    1998-08-01

    This project was initiated in October 1990, with the objective of developing and validating a new computer model of a recovery boiler furnace using a computational fluid dynamics (CFD) code specifically tailored to the requirements for solving recovery boiler flows, and using improved submodels for black liquor combustion based on continued laboratory fundamental studies. The key tasks to be accomplished were as follows: (1) Complete the development of enhanced furnace models that have the capability to accurately predict carryover, emissions behavior, dust concentrations, gas temperatures, and wall heat fluxes. (2) Validate the enhanced furnace models, so that users can have confidence in the predicted results. (3) Obtain fundamental information on aerosol formation, deposition, and hardening so as to develop the knowledge base needed to relate furnace model outputs to plugging and fouling in the convective sections of the boiler. (4) Facilitate the transfer of codes, black liquid submodels, and fundamental knowledge to the US kraft pulp industry. Volume 3 contains the following appendix sections: Formation and destruction of nitrogen oxides in recovery boilers; Sintering and densification of recovery boiler deposits laboratory data and a rate model; and Experimental data on rates of particulate formation during char bed burning.

  3. The history of NATO TNF policy: The role of studies, analysis and exercises conference proceedings. Volume 3: Papers by Gen. Robert C. Richardson III (Ret.)

    Energy Technology Data Exchange (ETDEWEB)

    Rinne, R.L. [ed.

    1994-02-01

    This conference was organized to study and analyze the role of simulation, analysis, modeling, and exercises in the history of NATO policy. The premise was not that the results of past studies will apply to future policy, but rather that understanding what influenced the decision process-and how-would be of value. The structure of the conference was built around discussion panels. The panels were augmented by a series of papers and presentations focusing on particular TNF events, issues, studies, or exercises. The conference proceedings consist of three volumes. Volume 1 contains the conference introduction, agenda, biographical sketches of principal participants, and analytical summary of the presentations and discussion panels. Volume 2 contains a short introduction and the papers and presentations from the conference. This volume contains selected papers by Brig. Gen. Robert C. Richardson III (Ret.).

  4. Model predictions of realgar precipitation by reaction of As(III) with synthetic mackinawite under anoxic conditions

    Science.gov (United States)

    Gallegos, T.J.; Han, Y.-S.; Hayes, K.F.

    2008-01-01

    This study investigates the removal of As(III) from solution using mackinawite, a nanoparticulate reduced iron sulfide. Mackinawite suspensions (0.1-40 g/L) effectively lower initial concentrations of 1.3 ?? 10 -5 M As(III) from pH 5-10, with maximum removal occurring under acidic conditions. Based on Eh measurements, it was found that the redox state of the system depended on the mackinawite solids concentration and pH. Higher initial mackinawite concentrations and alkaline pH resulted in a more reducing redox condition. Given this, the pH edge data were modeled thermodynamically using pe (-log[e-]) as a fitting parameter and linear pe-pH relationships within the range of measured Eh values as a function of pH and mackinawite concentration. The model predicts removal of As(III) from solution by precipitation of realgar with the formation of secondary oxidation products, greigite or a mixed-valence iron oxide phase, depending on pH. This study demonstrates that mackinawite is an effective sequestration agent for As(III) and highlights the importance of incorporating redox into models describing the As-Fe-S-H2O system. ?? 2008 American Chemical Society.

  5. Current and future industrial energy service characterizations. Volume III. Energy data on 15 selected states' manufacturing subsector

    Energy Technology Data Exchange (ETDEWEB)

    Krawiec, F.; Thomas, T.; Jackson, F.; Limaye, D.R.; Isser, S.; Karnofsky, K.; Davis, T.D.

    1980-11-01

    An examination is made of the current and future energy demands, and uses, and cost to characterize typical applications and resulting services in the US and industrial sectors of 15 selected states. Volume III presents tables containing data on selected states' manufacturing subsector energy consumption, functional uses, and cost in 1974 and 1976. Alabama, California, Illinois, Indiana, Louisiana, Michigan, Missouri, New Jersey, New York, Ohio, Oregon, Pennsylvania, Texas, West Virginia, and Wisconsin were chosen as having the greatest potential for replacing conventional fuel with solar energy. Basic data on the quantities, cost, and types of fuel and electric energy purchased by industr for heat and power were obtained from the 1974 and 1976 Annual Survey of Manufacturers. The specific indutrial energy servic cracteristics developed for each selected state include. 1974 and 1976 manufacturing subsector fuels and electricity consumption by 2-, 3-, and 4-digit SIC and primary fuel (quantity and relative share); 1974 and 1976 manufacturing subsector fuel consumption by 2-, 3-, and 4-digit SIC and primary fuel (quantity and relative share); 1974 and 1976 manufacturing subsector average cost of purchsed fuels and electricity per million Btu by 2-, 3-, and 4-digit SIC and primary fuel (in 1976 dollars); 1974 and 1976 manufacturing subsector fuels and electric energy intensity by 2-, 3-, and 4-digit SIC and primary fuel (in 1976 dollars); manufacturing subsector average annual growth rates of (1) fuels and electricity consumption, (2) fuels and electric energy intensity, and (3) average cost of purchased fuels and electricity (1974 to 1976). Data are compiled on purchased fuels, distillate fuel oil, residual ful oil, coal, coal, and breeze, and natural gas. (MCW)

  6. A proteomics panel for predicting optimal primary cytoreduction in stage III/IV ovarian cancer

    DEFF Research Database (Denmark)

    Risum, Signe; Høgdall, Estrid; Engelholm, Svend A;

    2009-01-01

    The objective of this prospective study was to evaluate CA-125 and a 7-marker panel as predictors of incomplete primary cytoreduction in patients with stage III/IV ovarian cancer (OC). From September 2004 to January 2008, serum from 201 patients referred to surgery for a pelvic tumor was analyzed...

  7. Volume fraction prediction in biphasic flow using nuclear technique and artificial neural network

    Energy Technology Data Exchange (ETDEWEB)

    Salgado, Cesar M.; Brandao, Luis E.B., E-mail: otero@ien.gov.br, E-mail: brandao@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2015-07-01

    The volume fraction is one of the most important parameters used to characterize air-liquid two-phase flows. It is a physical value to determine other parameters, such as the phase's densities and to determine the flow rate of each phase. These parameters are important to predict the flow pattern and to determine a mathematical model for the system. To study, for example, heat transfer and pressure drop. This work presents a methodology for volume fractions prediction in water-gas stratified flow regime using the nuclear technique and artificial intelligence. The volume fractions calculate in biphasic flow systems is complex and the analysis by means of analytical equations becomes very difficult. The approach is based on gamma-ray pulse height distributions pattern recognition by means of the artificial neural network. The detection system uses appropriate broad beam geometry, comprised of a ({sup 137}Cs) energy gamma-ray source and a NaI(Tl) scintillation detector in order measure transmitted beam whose the counts rates are influenced by the phases composition. These distributions are directly used by the network without any parameterization of the measured signal. The ideal and static theoretical models for stratified regime have been developed using MCNP-X code, which was used to provide training, test and validation data for the network. The detector also was modeled with this code and the results were compared to experimental photopeak efficiency measurements of radiation sources. The proposed network could obtain with satisfactory prediction of the volume fraction in water-gas system, demonstrating to be a promising approach for this purpose. (author)

  8. Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed

    DEFF Research Database (Denmark)

    Posthuma, Daniëlle; Baare, Wim F.C.; Hulshoff Pol, Hilleke E.

    2003-01-01

    We recently showed that the correlation of gray and white matter volume with full scale IQ and the Working Memory dimension are completely mediated by common genetic factors (Posthuma et al., 2002). Here we examine whether the other WAIS III dimensions (Verbal Comprehension, Perceptual Organization...... to Working Memory capacity (r = 0.27). This phenotypic correlation is completely due to a common underlying genetic factor. Processing Speed was genetically related to white matter volume (r(g) = 0.39). Perceptual Organization was both genetically (r(g) = 0.39) and environmentally (r(e) = -0.71) related...

  9. Accurate prediction of secreted substrates and identification of a conserved putative secretion signal for type III secretion systems.

    Directory of Open Access Journals (Sweden)

    Ram Samudrala

    2009-04-01

    Full Text Available The type III secretion system is an essential component for virulence in many Gram-negative bacteria. Though components of the secretion system apparatus are conserved, its substrates--effector proteins--are not. We have used a novel computational approach to confidently identify new secreted effectors by integrating protein sequence-based features, including evolutionary measures such as the pattern of homologs in a range of other organisms, G+C content, amino acid composition, and the N-terminal 30 residues of the protein sequence. The method was trained on known effectors from the plant pathogen Pseudomonas syringae and validated on a set of effectors from the animal pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium after eliminating effectors with detectable sequence similarity. We show that this approach can predict known secreted effectors with high specificity and sensitivity. Furthermore, by considering a large set of effectors from multiple organisms, we computationally identify a common putative secretion signal in the N-terminal 20 residues of secreted effectors. This signal can be used to discriminate 46 out of 68 total known effectors from both organisms, suggesting that it is a real, shared signal applicable to many type III secreted effectors. We use the method to make novel predictions of secreted effectors in S. Typhimurium, some of which have been experimentally validated. We also apply the method to predict secreted effectors in the genetically intractable human pathogen Chlamydia trachomatis, identifying the majority of known secreted proteins in addition to providing a number of novel predictions. This approach provides a new way to identify secreted effectors in a broad range of pathogenic bacteria for further experimental characterization and provides insight into the nature of the type III secretion signal.

  10. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume III. Resources and fuel cycle facilities

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    Volume III explores resources and fuel cycle facilities. Chapters are devoted to: estimates of US uranium resources and supply; comparison of US uranium demands with US production capability forecasts; estimates of foreign uranium resources and supply; comparison of foreign uranium demands with foreign production capability forecasts; and world supply and demand for other resources and fuel cycle services. An appendix gives uranium, fissile material, and separative work requirements for selected reactors and fuel cycles.

  11. Pulse pressure variation and prediction of fluid responsiveness in patients ventilated with low tidal volumes

    Directory of Open Access Journals (Sweden)

    Clarice Daniele Alves de Oliveira-Costa

    2012-07-01

    Full Text Available OBJECTIVE: To determine the utility of pulse pressure variation (ΔRESP PP in predicting fluid responsiveness in patients ventilated with low tidal volumes (V T and to investigate whether a lower ΔRESP PP cut-off value should be used when patients are ventilated with low tidal volumes. METHOD: This cross-sectional observational study included 37 critically ill patients with acute circulatory failure who required fluid challenge. The patients were sedated and mechanically ventilated with a V T of 6-7 ml/kg ideal body weight, which was monitored with a pulmonary artery catheter and an arterial line. The mechanical ventilation and hemodynamic parameters, including ΔRESP PP, were measured before and after fluid challenge with 1,000 ml crystalloids or 500 ml colloids. Fluid responsiveness was defined as an increase in the cardiac index of at least 15%. ClinicalTrial.gov: NCT01569308. RESULTS: A total of 17 patients were classified as responders. Analysis of the area under the ROC curve (AUC showed that the optimal cut-off point for ΔRESP PP to predict fluid responsiveness was 10% (AUC = 0.74. Adjustment of the ΔRESP PP to account for driving pressure did not improve the accuracy (AUC = 0.76. A ΔRESP PP>10% was a better predictor of fluid responsiveness than central venous pressure (AUC = 0.57 or pulmonary wedge pressure (AUC = 051. Of the 37 patients, 25 were in septic shock. The AUC for ΔRESP PP>10% to predict responsiveness in patients with septic shock was 0.484 (sensitivity, 78%; specificity, 93%. CONCLUSION: The parameter D RESP PP has limited value in predicting fluid responsiveness in patients who are ventilated with low tidal volumes, but a ΔRESP PP>10% is a significant improvement over static parameters. A ΔRESP PP > 10% may be particularly useful for identifying responders in patients with septic shock.

  12. Salinity independent volume fraction prediction in water-gas-oil multiphase flows using artificial neural networks

    Energy Technology Data Exchange (ETDEWEB)

    Salgado, C.M.; Pereira, Claudio M.N.A.; Brandao, Luis E.B., E-mail: otero@ien.gov.b, E-mail: cmnap@ien.gov.b, E-mail: brandao@ien.gov.b [Instituto de Engenharia Nuclear (DIRA/IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Div. de Radiofarmacos

    2011-07-01

    This work investigates the response of a volume fraction prediction system for water-gas-oil multiphase flows considering variations on water salinity. The approach is based on gamma-ray pulse height distributions pattern recognition by means the artificial neural networks (ANNs). The detection system uses appropriate fan beam geometry, comprised of a dual-energy gamma-ray source and two NaI(Tl) detectors adequately positioned outside the pipe in order measure transmitted and scattered beams. An ideal and static theoretical model for annular flow regime have been developed using MCNP-X code, which was used to provide training, test and validation data for the ANN. More than 500 simulations have been done, in which water salinity have been ranged from 0 to 16% in order to cover a most practical situations. Validation tests have included values of volume fractions and water salinity different from those used in ANN training phase. The results presented here show that the proposed approach may be successfully applied to material volume fraction prediction on watergas- oil multiphase flows considering practical (real) levels of variations in water salinity. (author)

  13. Prediction of lateral surface, volume and sphericity of pomegranate using MLP artificial neural network

    Directory of Open Access Journals (Sweden)

    A Rohani

    2015-09-01

    Full Text Available Introduction: Fast and accurate determination of geometrical properties of agricultural products has many applications in agricultural operations like planting, cultivating, harvesting and post-harvesting. Calculations related to storing, shipping and storage-coating materials as well as peeling time and surface-microbial concentrations are some applications of estimating product volume and surface area. Sphericity is also a parameter by which the shape differences between fruits, vegetables, grains and seeds can be quantified. This parameter is important in grading systems and inspecting rolling capability of agricultural products. Bayram presented a new dimensional method and equation to calculate the sphericity of certain shapesand some granular food materials (Bayram, 2005. Kumar and Mathew proposed atheoretically soundmethod for estimating the surface area of ellipsoidal food materials (Kumar and Mathew, 2003. Clayton et al. used non-linear regression models for calculation of apple surface area using the fruit mass or volume (Clayton et al., 1995. Humeida and Hobani predicted surface area and volume of pomegranates based on the weight and geometrical diametermean (Humeida and Hobani, 1993. Wang and Nguang designeda low cost sensor system to automatically compute the volume and surface area of axi-symmetricagricultural products such as eggs, lemons, limes and tamarillos (Wang and Nguang, 2007. The main objective of this study was to investigate the potential of Artificial Neural Network (ANN technique as an alternative method to predict the volume, surface area and sphericity of pomegranates. Materials and methods: The water displacement method (WDM was used for measuring the actual volume of pomegranates. Also, the sphericity and surface area are computed by using analytical methods. In this study, the neural MLP models were designed based upon the three nominal diameters of pomegranatesas variable inputs, while the output model consisted

  14. Industrial Fuel Gas Demonstration Plant Program. Conceptual design and evaluation of commercial plant. Volume III. Economic analyses (Deliverable Nos. 15 and 16)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    This report presents the results of Task I of Phase I in the form of a Conceptual Design and Evaluation of Commercial Plant report. The report is presented in four volumes as follows: I - Executive Summary, II - Commercial Plant Design, III - Economic Analyses, IV - Demonstration Plant Recommendations. Volume III presents the economic analyses for the commercial plant and the supporting data. General cost and financing factors used in the analyses are tabulated. Three financing modes are considered. The product gas cost calculation procedure is identified and appendices present computer inputs and sample computer outputs for the MLGW, Utility, and Industry Base Cases. The results of the base case cost analyses for plant fenceline gas costs are as follows: Municipal Utility, (e.g. MLGW), $3.76/MM Btu; Investor Owned Utility, (25% equity), $4.48/MM Btu; and Investor Case, (100% equity), $5.21/MM Btu. The results of 47 IFG product cost sensitivity cases involving a dozen sensitivity variables are presented. Plant half size, coal cost, plant investment, and return on equity (industrial) are the most important sensitivity variables. Volume III also presents a summary discussion of the socioeconomic impact of the plant and a discussion of possible commercial incentives for development of IFG plants.

  15. Predicted costs of environmental controls for a commercial oil shale industry. Volume 1. An engineering analysis

    Energy Technology Data Exchange (ETDEWEB)

    Nevens, T.D.; Culbertson, W.J. Jr.; Wallace, J.R.; Taylor, G.C.; Jovanovich, A.P.; Prien, C.H.; Hicks, R.E.; Probstein, R.F.; Domahidy, G.

    1979-07-01

    The pollution control costs for a commercial oil shale industry were determined in a joint effort by Denver Research Institute, Water Purification Associates of Cambridge, and Stone and Webster Engineering of Boston and Denver. Four commercial oil shale processes were considered. The results in terms of cost per barrel of syncrude oil are predicted to be as follows: Paraho Process, $0.67 to $1.01; TOSCO II Process, $1.43 to $1.91; MIS Process, $2.02 to $3.03; and MIS/Lurgi-Ruhrgas Process, $1.68 to $2.43. Alternative pollution control equipment and integrated pollution control strategies were considered and optimal systems selected for each full-scale plant. A detailed inventory of equipment (along with the rationale for selection), a detailed description of control strategies, itemized costs and predicted emission levels are presented for each process. Capital and operating cost data are converted to a cost per barrel basis using detailed economic evaluation procedures. Ranges of cost are determined using a subjective self-assessment of uncertainty approach. An accepted methodology for probability encoding was used, and cost ranges are presented as subjective probability distributions. Volume I presents the detailed engineering results. Volume II presents the detailed analysis of uncertainty in the predicted costs.

  16. Prediction of Shrinkage Pore Volume Fraction Using a Dimensionless Niyama Criterion

    Science.gov (United States)

    Carlson, Kent D.; Beckermann, Christoph

    2009-01-01

    A method is presented to use a dimensionless form of the well-known Niyama criterion to directly predict the amount of shrinkage porosity that forms during solidification of metal alloy castings. The main advancement offered by this method is that it avoids the need to know the threshold Niyama value below which shrinkage porosity forms; such threshold values are generally unknown and alloy dependent. The dimensionless criterion accounts for both the local thermal conditions (as in the original Niyama criterion) and the properties and solidification characteristics of the alloy. Once a dimensionless Niyama criterion value is obtained from casting simulation results, the corresponding shrinkage pore volume fraction can be determined knowing only the solid fraction-temperature curve and the total solidification shrinkage of the alloy. Curves providing the shrinkage pore volume percentage as a function of the dimensionless Niyama criterion are given for WCB steel, aluminum alloy A356, and magnesium alloy AZ91D. The present method is used in a general-purpose casting simulation software package to predict shrinkage porosity in three-dimensional (3-D) castings. Comparisons between simulated and experimental shrinkage porosity results for a WCB steel plate casting demonstrate that this method can reasonably predict shrinkage. Additional simulations for magnesium alloy AZ91D illustrate that this method is applicable to a wide variety of alloys and casting conditions.

  17. Larger Lateral Prefrontal Cortex Volume Predicts Better Exercise Adherence Among Older Women: Evidence From Two Exercise Training Studies.

    Science.gov (United States)

    Best, John R; Chiu, Bryan K; Hall, Peter A; Liu-Ambrose, Teresa

    2017-06-01

    Recent research has suggested an important role of lateral prefrontal cortex (lPFC) in consistent implementation of positive health behaviors and avoidance of negative health behaviors. We examined whether gray matter volume in the lPFC prospectively predicts exercise class attendance among older women (n = 122) who underwent either a 52-week or 26-week exercise training intervention. Structural magnetic resonance imaging determined gray matter volume at baseline. Independent of intracranial volume, age, education, body composition, mobility, depressive symptoms, and general cognitive functioning, larger lPFC volume predicted greater exercise class attendance (all p values exercise adherence as well as identified other regions, especially in the insula and temporal cortex, that predicted exercise adherence. These findings suggest that sustained engagement in exercise training might rely in part on functions of the lPFC and that lPFC volume might be a reasonable proxy for such functions.

  18. Radical prostatectomy and positive surgical margins: tumor volume and Gleason score predicts cancer outcome

    Energy Technology Data Exchange (ETDEWEB)

    La Roca, Ricardo L.R. Felts de, E-mail: Ricardo@delarocaurologia.com.br [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil); Fonseca, Francisco Paula da, E-mail: fpf@uol.com.br [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Divisao de Urologia. Dept. de Cirurgia Pelvica; Cunha, Isabela Werneck da; Bezerra, Stephania Martins, E-mail: iwerneck@gmail.com, E-mail: stephaniab@gmail.com [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Dept. de Patologia

    2013-07-01

    Introduction: positive surgical margins (PSMs) are common adverse factors to predict the outcome of a patient submitted to radical prostatectomy (PR). However, not all of these men will follow with biochemical (BCR) or clinical (CR) recurrence. Relationship between PSMs with these recurrent events has to be correlated with other clinicopathological findings in order to recognize more aggressive tumors in order to recommend complementary treatment to these selected patients. Materials and methods: we retrospectively reviewed the outcome of 228 patients submitted to open retropubic RP between March 1991 and June 2008, where 161 had and 67 did not have PSMs. Minimum follow-up time was considered 2 years after surgery. BCR was considered when PSA {>=} 0.2 ng/ml. CR was determined when clinical evidence of tumor appeared. Chi-square test was used to correlate clinical and pathologic variables with PSMs. The estimated 5-year risk of BCR and CR in presence of PSMs was determined using the Kaplan-Meier method and compared to log-rank tests. Results: from the total of 228 patients, 161 (71%) had PSMs, while 67 (29%) had negative surgical margins (NSMs). Prostatic circumferential margin was the most common (43.4%) site. Univariate analysis showed statistically significant (p < 0.001) associations between the presence of PSMs and BCR, but not with CR (p = 0.06). Among 161 patients with PSMs, 61 (37.8%) presented BCR, while 100 (62.8%) did not. Predicting progression-free survival for 5 years, BCR was correlated with pathological stage; Gleason score; pre-treatment PSA; tumor volume in specimen; capsular and perineural invasion; presence and number of PSMs. RC correlated only with angiolymphatic invasion and Gleason score. Considering univariate analyses the clinicopathological factors predicting BCR for 5 years, results statistically significant links with prostate weight; pre-treatment PSA; Gleason score; pathological stage; tumor volume; PSMs; capsular and perineural

  19. A Review of the Definition and Measurement of Poverty: Volume I, Summary Review Paper; Volume II, Annotated Bibliography. The Measure of Poverty, Technical Paper III.

    Science.gov (United States)

    Oster, Sharon; And Others

    This study reviews the existing literature on a series of issues associated with the defintion and measurement of poverty, and it consists of a summary report covering this research (Volume I), and an annotated bibliography (Volume II). Eleven specific issues were identified and reviewed in this study: (1) the historical definitions of poverty,…

  20. Does Preinterventional Flat-Panel Computer Tomography Pooled Blood Volume Mapping Predict Final Infarct Volume After Mechanical Thrombectomy in Acute Cerebral Artery Occlusion?

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Marlies, E-mail: marlies.wagner@kgu.de [Hospital of Goethe University, Institute of Neuroradiology (Germany); Kyriakou, Yiannis, E-mail: yiannis.kyriakou@siemens.com [Siemens AG, Health Care Sector (Germany); Mesnil de Rochemont, Richard du, E-mail: mesnil@em.uni-frankfurt.de [Hospital of Goethe University, Institute of Neuroradiology (Germany); Singer, Oliver C., E-mail: o.singer@em.uni-frankfurt.de [Hospital of Goethe University, Department of Neurology (Germany); Berkefeld, Joachim, E-mail: berkefeld@em.uni-frankfurt.de [Hospital of Goethe University, Institute of Neuroradiology (Germany)

    2013-08-01

    PurposeDecreased cerebral blood volume is known to be a predictor for final infarct volume in acute cerebral artery occlusion. To evaluate the predictability of final infarct volume in patients with acute occlusion of the middle cerebral artery (MCA) or the distal internal carotid artery (ICA) and successful endovascular recanalization, pooled blood volume (PBV) was measured using flat-panel detector computed tomography (FPD CT).Materials and MethodsTwenty patients with acute unilateral occlusion of the MCA or distal ACI without demarcated infarction, as proven by CT at admission, and successful Thrombolysis in cerebral infarction score (TICI 2b or 3) endovascular thrombectomy were included. Cerebral PBV maps were acquired from each patient immediately before endovascular thrombectomy. Twenty-four hours after recanalization, each patient underwent multislice CT to visualize final infarct volume. Extent of the areas of decreased PBV was compared with the final infarct volume proven by follow-up CT the next day.ResultsIn 15 of 20 patients, areas of distinct PBV decrease corresponded to final infarct volume. In 5 patients, areas of decreased PBV overestimated final extension of ischemia probably due to inappropriate timing of data acquisition and misery perfusion.ConclusionPBV mapping using FPD CT is a promising tool to predict areas of irrecoverable brain parenchyma in acute thromboembolic stroke. Further validation is necessary before routine use for decision making for interventional thrombectomy.

  1. Prediction of 3-hydroxypyridin-4-one (HPO) log K1 values for Fe(III).

    Science.gov (United States)

    Chen, Yu-Lin; Barlow, Dave J; Kong, Xiao-Le; Ma, Yong-Min; Hider, Robert C

    2012-09-21

    As a means to aid in the design of 3-hydroxypyridin-4-ones (HPOs) intended for use as therapeutic Fe(3+) chelating agents, a novel methodology has been developed using quantum mechanical (QM) calculations for predicting the iron binding affinities of the compounds (more specifically, their log K(1) values). The reported/measured HPO log K(1) values were verified through their correlation with the corresponding sum of the compounds' ligating group pK(a) values. Using a training set of eleven HPOs with known log K(1) values, reliable predictions are shown to be obtained with QM calculations using the B3LYP/6-31+G(d)/CPCM model chemistry (with Bondi radii, and water as solvent). With this methodology, the observed log K(1) values for the training set compounds are closely matched by the predicted values, with the correlation between the observed and predicted values giving r(2) = 0.9. Predictions subsequently made by this method for a test set of 42 HPOs of known log K(1) values gave predicted values accurate to within ±0.32 log units. In order to further investigate the predictive power of the method, four novel HPOs were synthesised and their log K(1) values were determined experimentally. Comparison of these predicted log K(1) values against the measured values gave absolute deviations of 0.22 (13.87 vs. 14.09), 0.02 (14.31 vs. 14.29), 0.12 (14.62 vs. 14.50), and 0.13 (15.04 vs. 15.17). The prediction methodology reported here is the first to be provided for predicting the absolute log K(1) values of iron-chelating agents in the absence of pK(a) values.

  2. RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme.

    Science.gov (United States)

    Miao, Zhichao; Adamiak, Ryszard W; Antczak, Maciej; Batey, Robert T; Becka, Alexander J; Biesiada, Marcin; Boniecki, Michał J; Bujnicki, Janusz; Chen, Shi-Jie; Cheng, Clarence Yu; Chou, Fang-Chieh; Ferré-D'Amaré, Adrian R; Das, Rhiju; Dawson, Wayne K; Feng, Ding; Dokholyan, Nikolay V; Dunin-Horkawicz, Stanisław; Geniesse, Caleb; Kappel, Kalli; Kladwang, Wipapat; Krokhotin, Andrey; Łach, Grzegorz E; Major, François; Mann, Thomas H; Magnus, Marcin; Pachulska-Wieczorek, Katarzyna; Patel, Dinshaw J; Piccirilli, Joseph A; Popenda, Mariusz; Purzycka, Katarzyna J; Ren, Aiming; Rice, Greggory M; Santalucia, John; Sarzynska, Joanna; Szachniuk, Marta; Tandon, Arpit; Trausch, Jeremiah J; Tian, Siqi; Wang, Jian; Weeks, Kevin M; Williams, Benfeard; Xiao, Yi; Xu, Xiaojun; Zhang, Dong; Zok, Tomasz; Westhof, Eric

    2017-01-30

    RNA-Puzzles is a collective experiment in blind 3D RNA structure prediction. We report here a third round of RNA-Puzzles. Five puzzles, 4, 8, 12, 13, 14, all structures of riboswitch aptamers and puzzle 7, a ribozyme structure, are included in this round of the experiment. The riboswitch structures include biological binding sites for small molecules (S-adenosyl methionine, cyclic diadenosine monophosphate, 5-amino 4-imidazole carboxamide riboside 5'-triphosphate, glutamine) and proteins (YbxF) and one set describes large conformational changes between ligand-free and ligand-bound states; the Varkud satellite ribozyme is the most recently solved structure of a known large ribozyme. All the puzzles have established biological functions and require structural understanding to appreciate their molecular mechanisms. Through the use of fast-track experimental data, including multidimensional chemical mapping, and accurate prediction of RNA secondary structure, a large portion of the contacts in 3D have been predicted correctly leading to similar topologies for the top ranking predictions. Template-based and homology-derived predictions could predict structures to particularly high accuracies. However, achieving biological insights from de novo prediction of RNA 3D structures still depends on the size and complexity of the RNA. Blind computational predictions of RNA structures already appear to provide useful structural information in many cases. Similar to the previous RNA-Puzzles Round II experiment, the prediction of non-Watson-Crick interactions and the observed high atomic clash scores reveal notable need for algorithm of improvement. All prediction models and assessment results are available at http://ahsoka.u-strasbg.fr/rnapuzzles/.

  3. Establishment the code for prediction of waste volume on NPP decommissioning

    Energy Technology Data Exchange (ETDEWEB)

    Cho, W. H.; Park, S. K.; Choi, Y. D.; Kim, I. S.; Moon, J. K. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    In practice, decommissioning waste volume can be estimated appropriately by finding the differences between prediction and actual operation and considering the operational problem or supplementary matters. So in the nuclear developed countries such as U.S. or Japan, the decommissioning waste volume is predicted on the basis of the experience in their own decommissioning projects. Because of the contamination caused by radioactive material, decontamination activity and management of radio-active waste should be considered in decommissioning of nuclear facility unlike the usual plant or facility. As the decommissioning activity is performed repeatedly, data for similar activities are accumulated, and optimal strategy can be achieved by comparison with the predicted strategy. Therefore, a variety of decommissioning experiences are the most important. In Korea, there is no data on the decommissioning of commercial nuclear power plants yet. However, KAERI has accumulated the basis decommissioning data of nuclear facility through decommissioning of research reactor (KRR-2) and uranium conversion plant (UCP). And DECOMMIS(DECOMMissioning Information Management System) was developed to provide and manage the whole data of decommissioning project. Two codes, FAC code and WBS code, were established in this process. FAC code is the one which is classified by decommissioning target of nuclear facility, and WBS code is classified by each decommissioning activity. The reason why two codes where created is that the codes used in DEFACS (Decommissioning Facility Characterization management System) and DEWOCS (Decommissioning Work-unit productivity Calculation System) are different from each other, and they were classified each purpose. DEFACS which manages the facility needs the code that categorizes facility characteristics, and DEWOCS which calculates unit productivity needs the code that categorizes decommissioning waste volume. KAERI has accumulated decommissioning data of KRR

  4. Regional Differences in Brain Volume Predict the Acquisition of Skill in a Complex Real-Time Strategy Videogame

    Science.gov (United States)

    Basak, Chandramallika; Voss, Michelle W.; Erickson, Kirk I.; Boot, Walter R.; Kramer, Arthur F.

    2011-01-01

    Previous studies have found that differences in brain volume among older adults predict performance in laboratory tasks of executive control, memory, and motor learning. In the present study we asked whether regional differences in brain volume as assessed by the application of a voxel-based morphometry technique on high resolution MRI would also…

  5. Regional Differences in Brain Volume Predict the Acquisition of Skill in a Complex Real-Time Strategy Videogame

    Science.gov (United States)

    Basak, Chandramallika; Voss, Michelle W.; Erickson, Kirk I.; Boot, Walter R.; Kramer, Arthur F.

    2011-01-01

    Previous studies have found that differences in brain volume among older adults predict performance in laboratory tasks of executive control, memory, and motor learning. In the present study we asked whether regional differences in brain volume as assessed by the application of a voxel-based morphometry technique on high resolution MRI would also…

  6. Orbital change following Le Fort III advancement in syndromic craniosynostosis: quantitative evaluation of orbital volume, infra-orbital rim and globe position.

    Science.gov (United States)

    Nout, Erik; van Bezooijen, Jine S; Koudstaal, Maarten J; Veenland, Jifke F; Hop, Wim C J; Wolvius, Eppo B; van der Wal, Karel G H

    2012-04-01

    Patients with syndromic craniosynostosis suffering from shallow orbits due to midface hypoplasia can be treated with a Le Fort III advancement osteotomy. This study evaluates the influence of Le Fort III advancement on orbital volume, position of the infra-orbital rim and globe. In pre- and post-operative CT-scans of 18 syndromic craniosynostosis patients, segmentation of the left and right orbit was performed and the infra-orbital rim and globe were marked. By superimposing the pre- and post-operative scans and by creating a reference coordinate system, movements of the infra-orbital rim and globe were assessed. Orbital volume increased significantly, by 27.2% for the left and 28.4% for the right orbit. Significant anterior movements of the left infra-orbital rim of 12.0mm (SD 4.2) and right infra-orbital rim of 12.8mm (SD 4.9) were demonstrated. Significant medial movements of 1.7mm (SD 2.2) of the left globe and 1.5mm (SD 1.9) of the right globe were demonstrated. There was a significant correlation between anterior infra-orbital rim movement and the increase in orbital volume. Significant orbital volume increase has been demonstrated following Le Fort III advancement. The position of the infra-orbital rim was moved forward significantly, whereas the globe position remained relatively unaffected. Copyright © 2011 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  7. Retrospective study on predictive scoring system for amputation in open fracture of tibia type III

    Directory of Open Access Journals (Sweden)

    Made Bramantya Karna

    2016-08-01

    Results: Patients who undergo amputation were 12 people and who successfully maintained limb were 46 people. The sensitivity ranged from 50% (MESI until 75% (HFS, a specificity ranging from 61% (HFS until 85% (NISSA. Positive predictive value ranged between 23% (PSI and 53% (NISSA and negative predictive value ranged from 81% (PSI until 91% (NISSA. Conclusions: This study failed to demonstrate the usefulness of the six counting system because it only shows the sensitivity and specificity in distinguishing limb amputation injuries that require immediate and that allows it to be maintained. Some have incorrectly predicted the counting system, where some patients were successfully maintained limb had been predicted for amputees and vice versa. [Int J Res Med Sci 2016; 4(8.000: 3521-3524

  8. Sequence analyses and 3D structure prediction of two Type III ...

    African Journals Online (AJOL)

    Internet

    2012-04-17

    Apr 17, 2012 ... prediction and evolutionary profile of growth hormone (GH) from 14 ornamental freshwater fishes. The ... associated with characteristics of interest to animal breeding, such ..... distribution was used to model evolutionary rate.

  9. Egg volume prediction using machine vision technique based on pappus theorem and artificial neural network.

    Science.gov (United States)

    Soltani, Mahmoud; Omid, Mahmoud; Alimardani, Reza

    2015-05-01

    Egg size is one of the important properties of egg that is judged by customers. Accordingly, in egg sorting and grading, the size of eggs must be considered. In this research, a new method of egg volume prediction was proposed without need to measure weight of egg. An accurate and efficient image processing algorithm was designed and implemented for computing major and minor diameters of eggs. Two methods of egg size modeling were developed. In the first method, a mathematical model was proposed based on Pappus theorem. In second method, Artificial Neural Network (ANN) technique was used to estimate egg volume. The determined egg volume by these methods was compared statistically with actual values. For mathematical modeling, the R(2), Mean absolute error and maximum absolute error values were obtained as 0.99, 0.59 cm(3) and 1.69 cm(3), respectively. To determine the best ANN, R(2) test and RMSEtest were used as selection criteria. The best ANN topology was 2-28-1 which had the R(2) test and RMSEtest of 0.992 and 0.66, respectively. After system calibration, the proposed models were evaluated. The results which indicated the mathematical modeling yielded more satisfying results. So this technique was selected for egg size determination.

  10. Cervical Vertebral Body’s Volume as a New Parameter for Predicting the Skeletal Maturation Stages

    Directory of Open Access Journals (Sweden)

    Youn-Kyung Choi

    2016-01-01

    Full Text Available This study aimed to determine the correlation between the volumetric parameters derived from the images of the second, third, and fourth cervical vertebrae by using cone beam computed tomography with skeletal maturation stages and to propose a new formula for predicting skeletal maturation by using regression analysis. We obtained the estimation of skeletal maturation levels from hand-wrist radiographs and volume parameters derived from the second, third, and fourth cervical vertebrae bodies from 102 Japanese patients (54 women and 48 men, 5–18 years of age. We performed Pearson’s correlation coefficient analysis and simple regression analysis. All volume parameters derived from the second, third, and fourth cervical vertebrae exhibited statistically significant correlations (P<0.05. The simple regression model with the greatest R-square indicated the fourth-cervical-vertebra volume as an independent variable with a variance inflation factor less than ten. The explanation power was 81.76%. Volumetric parameters of cervical vertebrae using cone beam computed tomography are useful in regression models. The derived regression model has the potential for clinical application as it enables a simple and quantitative analysis to evaluate skeletal maturation level.

  11. Accurate prediction of secreted substrates and identification of a conserved putative secretion signal for type III secretion systems

    Energy Technology Data Exchange (ETDEWEB)

    Samudrala, Ram; Heffron, Fred; McDermott, Jason E.

    2009-04-24

    The type III secretion system is an essential component for virulence in many Gram-negative bacteria. Though components of the secretion system apparatus are conserved, its substrates, effector proteins, are not. We have used a machine learning approach to identify new secreted effectors. The method integrates evolutionary measures, such as the pattern of homologs in a range of other organisms, and sequence-based features, such as G+C content, amino acid composition and the N-terminal 30 residues of the protein sequence. The method was trained on known effectors from Salmonella typhimurium and validated on a corresponding set of effectors from Pseudomonas syringae, after eliminating effectors with detectable sequence similarity. The method was able to identify all of the known effectors in P. syringae with a specificity of 84% and sensitivity of 82%. The reciprocal validation, training on P. syringae and validating on S. typhimurium, gave similar results with a specificity of 86% when the sensitivity level was 87%. These results show that type III effectors in disparate organisms share common features. We found that maximal performance is attained by including an N-terminal sequence of only 30 residues, which agrees with previous studies indicating that this region contains the secretion signal. We then used the method to define the most important residues in this putative secretion signal. Finally, we present novel predictions of secreted effectors in S. typhimurium, some of which have been experimentally validated, and apply the method to predict secreted effectors in the genetically intractable human pathogen Chlamydia trachomatis. This approach is a novel and effective way to identify secreted effectors in a broad range of pathogenic bacteria for further experimental characterization and provides insight into the nature of the type III secretion signal.

  12. Structure Prediction Based on Hydrophobic to Hydrophilic Volume Ratios in Small Molecule Amphiphilic Organic Crystals

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The structure type for the crystal of 4,4'-bis-(2-hydroxy-ethoxyl)-biphenyl 1 has been predicted by using the previously developed interfacial model for small organic molecules. Based on the calculated hydrophobic to hydrophilic volume of 1, this model predicts the crystal structure to be of lamellar or bicontinuous type, which has been confirmed by the X-ray single-crystal structure analysis (C20H26O6, monoclinic, P21/c, a = 16.084(1), b = 6.0103(4), c = 9.6410(7)(A), β = 103.014(2)°, V = 908.1(1)(A)3, Z = 2, Dc = 1.325 g/cm3, F(000)=388, μ = 0.097 mm-1, MoKα radiation, λ = 0.71073 (A), R = 0.0382 and wR = 0.0882 with I > 2σ(I) for 7121 reflections collected, 1852 unique reflections and 170 parameters). As predicted, the hydrophobic and hydrophilic portions of 1 form in the lamellae. The same interfacial model is applied to other amphilphilic small molecule organic systems for structural type prediction.

  13. Prediction of quantitative intrathoracic fluid volume to diagnose pulmonary oedema using LabVIEW.

    Science.gov (United States)

    Urooj, Shabana; Khan, M; Ansari, A Q; Lay-Ekuakille, Aimé; Salhan, Ashok K

    2012-01-01

    Pulmonary oedema is a life-threatening disease that requires special attention in the area of research and clinical diagnosis. Computer-based techniques are rarely used to quantify the intrathoracic fluid volume (IFV) for diagnostic purposes. This paper discusses a software program developed to detect and diagnose pulmonary oedema using LabVIEW. The software runs on anthropometric dimensions and physiological parameters, mainly transthoracic electrical impedance (TEI). This technique is accurate and faster than existing manual techniques. The LabVIEW software was used to compute the parameters required to quantify IFV. An equation relating per cent control and IFV was obtained. The results of predicted TEI and measured TEI were compared with previously reported data to validate the developed program. It was found that the predicted values of TEI obtained from the computer-based technique were much closer to the measured values of TEI. Six new subjects were enrolled to measure and predict transthoracic impedance and hence to quantify IFV. A similar difference was also observed in the measured and predicted values of TEI for the new subjects.

  14. In silico prediction of the effects of mutations in the human UDP-galactose 4'-epimerase gene: towards a predictive framework for type III galactosemia.

    Science.gov (United States)

    McCorvie, Thomas J; Timson, David J

    2013-07-25

    The enzyme UDP-galactose 4'-epimerase (GALE) catalyses the reversible epimerisation of both UDP-galactose and UDP-N-acetyl-galactosamine. Deficiency of the human enzyme (hGALE) is associated with type III galactosemia. The majority of known mutations in hGALE are missense and private thus making clinical guidance difficult. In this study a bioinformatics approach was employed to analyse the structural effects due to each mutation using both the UDP-glucose and UDP-N-acetylglucosamine bound structures of the wild-type protein. Changes to the enzyme's overall stability, substrate/cofactor binding and propensity to aggregate were also predicted. These predictions were found to be in good agreement with previous in vitro and in vivo studies when data was available and allowed for the differentiation of those mutants that severely impair the enzyme's activity against UDP-galactose. Next this combination of techniques were applied to another twenty-six reported variants from the NCBI dbSNP database that have yet to be studied to predict their effects. This identified p.I14T, p.R184H and p.G302R as likely severely impairing mutations. Although severely impaired mutants were predicted to decrease the protein's stability, overall predicted stability changes only weakly correlated with residual activity against UDP-galactose. This suggests other protein functions such as changes in cofactor and substrate binding may also contribute to the mechanism of impairment. Finally this investigation shows that this combination of different in silico approaches is useful in predicting the effects of mutations and that it could be the basis of an initial prediction of likely clinical severity when new hGALE mutants are discovered.

  15. The role of mean platelet volume predicting acute exacerbations of cystic fibrosis in children

    Directory of Open Access Journals (Sweden)

    Pinar Uysal

    2011-01-01

    Full Text Available Objective: The aim of this study is to evaluate the relationship between acute exacerbations and the mean platelet volume (MPV trend in children with cystic fibrosis (CF, to predict the exacerbations. Methods: A total of 46 children with CF and 37 healthy children were enrolled in the study. White blood cell count (WBC, hemoglobin level, platelet count, mean platelet volume (MPV, and mean corpuscular volume (MCV were retrospectively recorded. Results: Our study population consisted of 25 (54.3% males and 21 (45.7% females with CF and 20 (54.0% males and 17 (46.0% females in the healthy control group. The mean age of the CF patients was 6.32 ± 4.9 years and that of the healthy subjects was 7.02 ± 3.15 years. In the acute exacerbation period of CF, the MPV values were lower and WBC and platelet counts were higher than those in the healthy controls (P = 0.00, P = 0.00, P = 0.00, respectively. Besides, in acute exacerbation, the MPV values were lower and the WBC count was higher than the values in the non-exacerbation period (P 0= 0.01, P = 0.00, respectively. In the non-exacerbation period MPV was lower and platelet count was higher when compared to healthy subjects (P = 0.02, P = 0.04, respectively. Conclusion: This study suggests that MPV might be used as a simple, cost effective, diagnostic, predictive indicator for platelet activation in pediatric CF patients related to chronic inflammation, which might be helpful to discriminate or estimate exacerbations.

  16. Predicting the probability and volume of postwildfire debris flows in the intermountain western United States

    Science.gov (United States)

    Cannon, S.H.; Gartner, J.E.; Rupert, M.G.; Michael, J.A.; Rea, A.H.; Parrett, C.

    2010-01-01

    Empirical models to estimate the probability of occurrence and volume of postwildfire debris flows can be quickly implemented in a geographic information system (GIS) to generate debris-flow hazard maps either before or immediately following wildfires. Models that can be used to calculate the probability of debris-flow production from individual drainage basins in response to a given storm were developed using logistic regression analyses of a database from 388 basins located in 15 burned areas located throughout the U.S. Intermountain West. The models describe debris-flow probability as a function of readily obtained measures of areal burned extent, soil properties, basin morphology, and rainfall from short-duration and low-recurrence-interval convective rainstorms. A model for estimating the volume of material that may issue from a basin mouth in response to a given storm was developed using multiple linear regression analysis of a database from 56 basins burned by eight fires. This model describes debris-flow volume as a function of the basin gradient, aerial burned extent, and storm rainfall. Applications of a probability model and the volume model for hazard assessments are illustrated using information from the 2003 Hot Creek fire in central Idaho. The predictive strength of the approach in this setting is evaluated using information on the response of this fire to a localized thunderstorm in August 2003. The mapping approach presented here identifies those basins that are most prone to the largest debris-flow events and thus provides information necessary to prioritize areas for postfire erosion mitigation, warnings, and prefire management efforts throughout the Intermountain West.

  17. Contemporary American Success Stories. Famous People of Asian Ancestry. Volume III. A Mitchell Lane Multicultural Biography Series.

    Science.gov (United States)

    Marvis, Barbara J.

    As part of a five-volume series written at a reading level for grades five to six and as a tribute to the contributions Asian Americans have made to the United States, this volume presents biographical sketches of Asian Americans who can serve as role models for today's youth. The profiles in the series show the triumph of the human spirit. Volume…

  18. Broadband Trailing-Edge Noise Predictions - Overview of BANC-III Results

    DEFF Research Database (Denmark)

    Herr, M.; Ewert, R.; Rautmann, C.

    2015-01-01

    The Third Workshop on Benchmark Problems for Airframe Noise Computations, BANCIII, was held on 14-15 June 2014 in Atlanta, Georgia, USA. The objective of this workshop was to assess the present computational capability in the area of physics-based prediction of different types of airframe noise...

  19. Changes in Stroke Volume Induced by Lung Recruitment Maneuver Predict Fluid Responsiveness in Mechanically Ventilated Patients in the Operating Room.

    Science.gov (United States)

    Biais, Matthieu; Lanchon, Romain; Sesay, Musa; Le Gall, Lisa; Pereira, Bruno; Futier, Emmanuel; Nouette-Gaulain, Karine

    2017-02-01

    Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the magnitude of stroke volume reduction through lung recruitment maneuver could predict preload responsiveness. Twenty-eight mechanically ventilated patients with low tidal volume during general anesthesia were included. Heart rate, mean arterial pressure, stroke volume, and pulse pressure variations were recorded before lung recruitment maneuver (application of continuous positive airway pressure of 30 cm H2O for 30 s), during lung recruitment maneuver when stroke volume reached its minimal value, and before and after volume expansion (250 ml saline, 0.9%, infused during 10 min). Patients were considered as responders to fluid administration if stroke volume increased greater than or equal to 10%. Sixteen patients were responders. Lung recruitment maneuver induced a significant decrease in mean arterial pressure and stroke volume in both responders and nonresponders. Changes in stroke volume induced by lung recruitment maneuver were correlated with those induced by volume expansion (r = 0.56; P recruitment maneuver predicted fluid responsiveness with a sensitivity of 88% (95% CI, 62 to 98) and a specificity of 92% (95% CI, 62 to 99). Pulse pressure variations more than 6% before lung recruitment maneuver discriminated responders with a sensitivity of 69% (95% CI, 41 to 89) and a specificity of 75% (95% CI, 42 to 95). The area under receiver operating curves generated for changes in stroke volume induced by lung recruitment maneuver (0.96; 95% CI, 0.81 to 0.99) was significantly higher than that for pulse pressure variations (0.72; 95% CI, 0.52 to 0.88; P recruitment maneuver could predict preload responsiveness in mechanically ventilated patients in the operating room.

  20. Validation that Metabolic Tumor Volume Predicts Outcome in Head and Neck Cancer

    Science.gov (United States)

    Tang, Chad; Murphy, James D.; Khong, Brian; La, Trang H.; Kong, Christina; Fischbein, Nancy J.; Colevas, A. Dimitrios; Iagaru, Andrei H.; Graves, Edward E.; Loo, Billy W.; Le, Quynh-Thu

    2011-01-01

    Purpose We have previously reported that metabolic tumor volume (MTV) obtained from pre-treatment FDG PET/CT predicted outcome in patients with head-and-neck cancer (HNC). The purpose of this study is to validate these results on an independent dataset, determine if the primary tumor or nodal MTV drives this correlation, and explore the interaction with p16INK4a status as a surrogate marker for HPV. Methods and Materials The validation dataset in this study included 83 patients with squamous cell HNC who had a FDG PET/CT scan prior to definitive radiotherapy. MTV and SUVmax were calculated for the primary tumor, involved nodes, and the combination of both. The primary endpoint was to validate that MTV predicted progression-free survival and overall survival. Secondary analyses included determining the prognostic utility of primary tumor versus nodal MTV. Results Similar to our prior findings, an increase in total MTV of 17 cm3 (difference between 75th and 25th percentile) was associated with a 2.1 fold increase in the risk of disease progression (p=0.0002), and a 2.0 fold increase in the risk of death (p=0.0048). SUVmax was not associated with either outcome. Primary tumor MTV predicted progression-free (HR=1.94; p<0.0001) and overall (HR=1.57; p<0.0001) survival, whereas nodal MTV did not. In addition, MTV predicted progression-free (HR=4.23; p<0.0001) and overall (HR=3.21; p=0.0029) survival in patients with p16INK4a positive oropharyngeal cancer. Conclusions This study validates our previous findings that MTV independently predicts outcomes in HNC. MTV should be considered as a potential risk stratifying biomarker in future studies of HNC. PMID:22270174

  1. CT angiography and CT perfusion improve prediction of infarct volume in patients with anterior circulation stroke

    Energy Technology Data Exchange (ETDEWEB)

    Seeters, Tom van; Schaaf, Irene C. van der; Dankbaar, Jan Willem; Horsch, Alexander D.; Niesten, Joris M.; Luitse, Merel J.A.; Mali, Willem P.T.M.; Velthuis, Birgitta K. [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Biessels, Geert Jan; Kappelle, L.J. [University Medical Center Utrecht, Department of Neurology, Brain Center Rudolf Magnus, Utrecht (Netherlands); Majoie, Charles B.L.M. [Academic Medical Center, Department of Radiology, Amsterdam (Netherlands); Vos, Jan Albert [St. Antonius Hospital, Department of Radiology, Nieuwegein (Netherlands); Schonewille, Wouter J. [St. Antonius Hospital, Department of Neurology, Nieuwegein (Netherlands); Walderveen, Marianne A.A. van [Leiden University Medical Center, Department of Radiology, Leiden (Netherlands); Wermer, Marieke J.H. [Leiden University Medical Center, Department of Neurology, Leiden (Netherlands); Duijm, Lucien E.M. [Catharina Hospital, Department of Radiology, Eindhoven (Netherlands); Keizer, Koos [Catharina Hospital, Department of Neurology, Eindhoven (Netherlands); Bot, Joseph C.J. [VU University Medical Center, Department of Radiology, Amsterdam (Netherlands); Visser, Marieke C. [VU University Medical Center, Department of Neurology, Amsterdam (Netherlands); Lugt, Aad van der [Erasmus MC University Medical Center, Department of Radiology, Rotterdam (Netherlands); Dippel, Diederik W.J. [Erasmus MC University Medical Center, Department of Neurology, Rotterdam (Netherlands); Kesselring, F.O.H.W. [Rijnstate Hospital, Department of Radiology, Arnhem (Netherlands); Hofmeijer, Jeannette [Rijnstate Hospital, Department of Neurology, Arnhem (Netherlands); Lycklama a Nijeholt, Geert J. [Medical Center Haaglanden, Department of Radiology, The Hague (Netherlands); Boiten, Jelis [Medical Center Haaglanden, Department of Neurology, The Hague (Netherlands); Rooij, Willem Jan van [St. Elisabeth Hospital, Department of Radiology, Tilburg (Netherlands); Kort, Paul L.M. de [St. Elisabeth Hospital, Department of Neurology, Tilburg (Netherlands); Roos, Yvo B.W.E.M. [Academic Medical Center, Department of Neurology, Amsterdam (Netherlands); Meijer, Frederick J.A. [Radboud University Medical Center, Department of Radiology, Nijmegen (Netherlands); Pleiter, C.C. [St. Franciscus Hospital, Department of Radiology, Rotterdam (Netherlands); Graaf, Yolanda van der [University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht (Netherlands); Collaboration: Dutch acute stroke study (DUST) investigators

    2016-04-15

    We investigated whether baseline CT angiography (CTA) and CT perfusion (CTP) in acute ischemic stroke could improve prediction of infarct presence and infarct volume on follow-up imaging. We analyzed 906 patients with suspected anterior circulation stroke from the prospective multicenter Dutch acute stroke study (DUST). All patients underwent baseline non-contrast CT, CTA, and CTP and follow-up non-contrast CT/MRI after 3 days. Multivariable regression models were developed including patient characteristics and non-contrast CT, and subsequently, CTA and CTP measures were added. The increase in area under the curve (AUC) and R{sup 2} was assessed to determine the additional value of CTA and CTP. At follow-up, 612 patients (67.5 %) had a detectable infarct on CT/MRI; median infarct volume was 14.8 mL (interquartile range (IQR) 2.8-69.6). Regarding infarct presence, the AUC of 0.82 (95 % confidence interval (CI) 0.79-0.85) for patient characteristics and non-contrast CT was improved with addition of CTA measures (AUC 0.85 (95 % CI 0.82-0.87); p < 0.001) and was even higher after addition of CTP measures (AUC 0.89 (95 % CI 0.87-0.91); p < 0.001) and combined CTA/CTP measures (AUC 0.89 (95 % CI 0.87-0.91); p < 0.001). For infarct volume, adding combined CTA/CTP measures (R{sup 2} = 0.58) was superior to patient characteristics and non-contrast CT alone (R{sup 2} = 0.44) and to addition of CTA alone (R{sup 2} = 0.55) or CTP alone (R{sup 2} = 0.54; all p < 0.001). In the acute stage, CTA and CTP have additional value over patient characteristics and non-contrast CT for predicting infarct presence and infarct volume on follow-up imaging. These findings could be applied for patient selection in future trials on ischemic stroke treatment. (orig.)

  2. An Adaptive Prediction-Based Approach to Lossless Compression of Floating-Point Volume Data.

    Science.gov (United States)

    Fout, N; Ma, Kwan-Liu

    2012-12-01

    In this work, we address the problem of lossless compression of scientific and medical floating-point volume data. We propose two prediction-based compression methods that share a common framework, which consists of a switched prediction scheme wherein the best predictor out of a preset group of linear predictors is selected. Such a scheme is able to adapt to different datasets as well as to varying statistics within the data. The first method, called APE (Adaptive Polynomial Encoder), uses a family of structured interpolating polynomials for prediction, while the second method, which we refer to as ACE (Adaptive Combined Encoder), combines predictors from previous work with the polynomial predictors to yield a more flexible, powerful encoder that is able to effectively decorrelate a wide range of data. In addition, in order to facilitate efficient visualization of compressed data, our scheme provides an option to partition floating-point values in such a way as to provide a progressive representation. We compare our two compressors to existing state-of-the-art lossless floating-point compressors for scientific data, with our data suite including both computer simulations and observational measurements. The results demonstrate that our polynomial predictor, APE, is comparable to previous approaches in terms of speed but achieves better compression rates on average. ACE, our combined predictor, while somewhat slower, is able to achieve the best compression rate on all datasets, with significantly better rates on most of the datasets.

  3. Long Range Weather Prediction III: Miniaturized Distributed Sensors for Global Atmospheric Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Teller, E; Leith, C; Canavan, G; Wood, L

    2001-11-13

    We continue consideration of ways-and-means for creating, in an evolutionary, ever-more-powerful manner, a continually-updated data-base of salient atmospheric properties sufficient for finite differenced integration-based, high-fidelity weather prediction over intervals of 2-3 weeks, leveraging the 10{sup 14} FLOPS digital computing systems now coming into existence. A constellation comprised of 10{sup 6}-10{sup 9} small atmospheric sampling systems--high-tech superpressure balloons carrying early 21st century semiconductor devices, drifting with the local winds over the meteorological spectrum of pressure-altitudes--that assays all portions of the troposphere and lower stratosphere remains the central feature of the proposed system. We suggest that these devices should be active-signaling, rather than passive-transponding, as we had previously proposed only for the ground- and aquatic-situated sensors of this system. Instead of periodic interrogation of the intra-atmospheric transponder population by a constellation of sophisticated small satellites in low Earth orbit, we now propose to retrieve information from the instrumented balloon constellation by existing satellite telephony systems, acting as cellular tower-nodes in a global cellular telephony system whose ''user-set'' is the atmospheric-sampling and surface-level monitoring constellations. We thereby leverage the huge investment in cellular (satellite) telephony and GPS technologies, with large technical and economic gains. This proposal minimizes sponsor forward commitment along its entire programmatic trajectory, and moreover may return data of weather-predictive value soon after field activities commence. We emphasize its high near-term value for making better mesoscale, relatively short-term weather predictions with computing-intensive means, and its great long-term utility in enhancing the meteorological basis for global change predictive studies. We again note that adverse

  4. Post-Radiation Metabolic Tumor Volume Predicts Outcome in Head-and-Neck Cancer

    Science.gov (United States)

    Murphy, James D; La, Trang H.; Chu, Karen; Quon, Andrew; Fischbein, Nancy J.; Maxim, Peter G.; Graves, Edward E.; Loo, Billy W.; Le, Quynh-Thu

    2010-01-01

    Purpose To explore the prognostic value of metabolic tumor volume measured on post-radiation 18F-fluorodeoxyglucose positron emission tomography (PET) imaging in head-and-neck cancer patients. Methods and Materials Forty-seven head-and-neck cancer patients who received pre- and post-treatment PET/CT imaging along with definitive chemoradiotherapy were included in this study. PET/CT parameters evaluated include the maximum standardized uptake value, metabolic tumor volume (MTV2.0-MTV4.0; where MTV2.0 refers to the volume above an SUV threshold of 2.0), and integrated tumor volume. Kaplan-Meier and Cox-regression models were used to test for association between PET endpoints and disease-free survival (DFS) and overall survival (OS). Results Multiple post-radiation PET endpoints correlated significantly with outcome, however the most robust predictor of disease progression and death was MTV2.0. An increase in MTV2.0 of 21cm3 (difference between 75th and 25th percentile) was associated with an increased risk of disease progression (hazard ratio [HR]=2.5, p=0.0001) and death (HR=2.0, p=0.003). In patients with non-nasopharyngeal carcinoma (non-NPC) histology (n=34), MTV2.0<18cm3 and MTV2.0≥18cm3 yielded 2-year DFS rates of 100% and 63%, respectively (p=0.006) and 2-year OS rates of 100% and 81%, respectively (p=0.009). There was no correlation between MTV2.0 and DFS or OS with NPC histology (n=13). On multivariate analysis only post-radiation MTV2.0 was predictive of DFS (HR=2.47, p=0.0001) and OS (HR=1.98, p=0.003). Conclusions Post-radiation metabolic tumor volume is an adverse prognostic factor in head-and-neck cancer. Biomarkers such as MTV are important for risk stratification, and will be valuable in the future with risk-adapted therapies. PMID:20646870

  5. Long Range Weather Prediction III: Miniaturized Distributed Sensors for Global Atmospheric Measurements

    Science.gov (United States)

    Teller, E.; Leith, C.; Canavan, G.; Wood, L.

    2001-11-13

    We continue consideration of ways-and-means for creating, in an evolutionary, ever-more-powerful manner, a continually-updated data-base of salient atmospheric properties sufficient for finite differenced integration-based, high-fidelity weather prediction over intervals of 2-3 weeks, leveraging the 10{sup 14} FLOPS digital computing systems now coming into existence. A constellation comprised of 10{sup 6}-10{sup 9} small atmospheric sampling systems--high-tech superpressure balloons carrying early 21st century semiconductor devices, drifting with the local winds over the meteorological spectrum of pressure-altitudes--that assays all portions of the troposphere and lower stratosphere remains the central feature of the proposed system. We suggest that these devices should be active-signaling, rather than passive-transponding, as we had previously proposed only for the ground- and aquatic-situated sensors of this system. Instead of periodic interrogation of the intra-atmospheric transponder population by a constellation of sophisticated small satellites in low Earth orbit, we now propose to retrieve information from the instrumented balloon constellation by existing satellite telephony systems, acting as cellular tower-nodes in a global cellular telephony system whose ''user-set'' is the atmospheric-sampling and surface-level monitoring constellations. We thereby leverage the huge investment in cellular (satellite) telephony and GPS technologies, with large technical and economic gains. This proposal minimizes sponsor forward commitment along its entire programmatic trajectory, and moreover may return data of weather-predictive value soon after field activities commence. We emphasize its high near-term value for making better mesoscale, relatively short-term weather predictions with computing-intensive means, and its great long-term utility in enhancing the meteorological basis for global change predictive studies. We again note that adverse impacts of weather

  6. SOLVENT-BASED TO WATERBASED ADHESIVE-COATED SUBSTRATE RETROFIT - VOLUME III: LABEL MANUFACTURING CASE STUDY: NASHUA CORPORATION

    Science.gov (United States)

    This volume discusses Nashua Corporation's Omaha facility, a label and label stock manufacturing facility that no longer uses solvent-based adhesives. Information obtained includes issues related to the technical, economic, and environmental barriers and opportunities associated ...

  7. Predictability and Market Efficiency in Agricultural Futures Markets: a Perspective from Price-Volume Correlation Based on Wavelet Coherency Analysis

    Science.gov (United States)

    He, Ling-Yun; Wen, Xing-Chun

    2015-12-01

    In this paper, we use a time-frequency domain technique, namely, wavelet squared coherency, to examine the associations between the trading volumes of three agricultural futures and three different forms of these futures' daily closing prices, i.e. prices, returns and volatilities, over the past several years. These agricultural futures markets are selected from China as a typical case of the emerging countries, and from the US as a representative of the developed economies. We investigate correlations and lead-lag relationships between the trading volumes and the prices to detect the predictability and efficiency of these futures markets. The results suggest that the information contained in the trading volumes of the three agricultural futures markets in China can be applied to predict the prices or returns, while that in US has extremely weak predictive power for prices or returns. We also conduct the wavelet analysis on the relationships between the volumes and returns or volatilities to examine the existence of the two "stylized facts" proposed by Karpoff [J. M. Karpoff, The relation between price changes and trading volume: A survey, J. Financ. Quant. Anal.22(1) (1987) 109-126]. Different markets in the two countries perform differently in reproducing the two stylized facts. As the wavelet tools can decode nonlinear regularities and hidden patterns behind price-volume relationship in time-frequency space, different from the conventional econometric framework, this paper offers a new perspective into the market predictability and efficiency.

  8. Soil Properties Database of Spanish Soils Volume III.- Extremadura; Base de Datos de Propiedades Edafologicas de los Suelos Espanoles Volumen III.- Extremadura

    Energy Technology Data Exchange (ETDEWEB)

    Trueba, C.; Millam, R.; Schmid, T.; Roquero, C.; Magister, M.

    1998-12-01

    The soil vulnerability determines the sensitivity of the soil after an accidental radioactive contamination due to Cs-137 and Sr-90. The Departamento de Impacto Ambiental de la Energia of CIEMAT is carrying out an assessment of the radiological vulnerability of the different Spanish soils found on the Iberian Peninsula. This requires the knowledge of the soil properties for the various types of existing soils. In order to achieve this aim, a bibliographical compilation of soil profiles has been made to characterize the different soil types and create a database of their properties. Depending on the year of publication and the type of documentary source, the information compiled from the available bibliography is very heterogeneous. Therefore, an important effort has been made to normalize and process the information prior to its incorporation to the database. This volume presents the criteria applied to normalize and process the data as well as the soil properties of the various soil types belonging to the Comunidad Autonoma de Extremadura. (Author) 50 refs.

  9. Alaska Regional Energy Resources Planning Project, Phase 2: coal, hydroelectric, and energy alternatives. Volume III. Alaska's alternative energies and regional assessment inventory update

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    The Alaska Regional Energy Resources Planning Project is presented in three volumes. This volume, Vol. III, considers alternative energies and the regional assessment inventory update. The introductory chapter, Chapter 12, examines the historical background, current technological status, environmental impact, applicability to Alaska, and siting considerations for a number of alternative systems. All of the systems considered use or could use renewable energy resources. The chapters that follow are entitled: Very Small Hydropower (about 12 kW or less for rural and remote villages); Low-Temperature Geothermal Space Heating; Wind; Fuel Cells; Siting Criteria and Preliminary Screening of Communities for Alternate Energy Use; Wood Residues; Waste Heat; and Regional Assessment Invntory Update. (MCW)

  10. Predicting the pressure-volume curve of an elastic microsphere composite

    CERN Document Server

    De Pascalis, Riccardo; Parnell, William J

    2012-01-01

    The effective macroscopic response of nonlinear elastomeric inhomogeneous materials is of great interest in many applications including nonlinear composite materials and soft biological tissues. The interest of the present work is associated with a microsphere composite material, which is modelled as a matrix-inclusion composite. The matrix phase is a homogeneous isotropic nonlinear rubber-like material and the inclusion phase is more complex, consisting of a distribution of sizes of stiff thin spherical shells filled with gas. Experimentally, such materials have been shown to undergo complex deformation under cyclic loading. Here, we consider microspheres embedded in an unbounded host material and assume that a hydrostatic pressure is applied in the "far-field". Taking into account a variety of effects including buckling of the spherical shells, large deformation of the host phase and evolving microstructure, we derive a model predicting the pressure-relative volume change load curves. Nonlinear constitutive...

  11. Platelet volume indices as predictive biomarkers for diabetic complications in Type 2 diabetic patients

    Science.gov (United States)

    Buch, Archana; Kaur, Supreet; Nair, Rahul; Jain, Ambuj

    2017-01-01

    BACKGROUND: Platelet volume indices (PVI) such as mean platelet volume (MPV), platelet distribution width (PDW), and platelet-large cell ratio (P-LCR) are the indicators of increased platelet activity and can be considered as potential biomarkers for diabetic complications. PURPOSE: To study PVI in Type 2 diabetics with and without complications in comparison to nondiabetic patients. MATERIALS AND METHODS: A case–control study was conducted on 300 Type 2 diabetics and 200 nondiabetics. Detailed clinical history regarding duration, hypertension, and complications was taken. PVI was obtained using automated cell counter. Fasting blood glucose, hemoglobin A1c, lipid profile, creatinine were also obtained. Diabetics were further categorized into patients with complications and without complications. Statistical analysis was performed by Statistical Package for the Social Sciences Version 17 (Chicago, IL) Student's t-test and ANOVA test. RESULTS: Platelet count was significantly decreased in diabetics (P = 0.005). MPV was significantly increased in diabetic patients with complications as compared to diabetics without complications and nondiabetic group (P diabetics with and without complications and nondiabetics (P diabetic retinopathy (P = 0.000), nephropathy (P = 0.005), and diabetic foot (P = 0.048). PDW was significantly increased in diabetic retinopathy (P = 0.035) and nephropathy (P = 0.007). P-LCR had no statistically significant correlation with diabetic complications. CONCLUSION: MPV and PDW are predictive biomarkers of diabetic vascular complications. They are more significant in microvascular complications than macrovascular complications. PMID:28367021

  12. TP53 Mutational Status and Prediction of Benefit from Adjuvant 5-Fluorouracil in Stage III Colon Cancer Patients.

    Science.gov (United States)

    Kandioler, Daniela; Mittlböck, Martina; Kappel, Sonja; Puhalla, Harald; Herbst, Friedrich; Langner, Cord; Wolf, Brigitte; Tschmelitsch, Jörg; Schippinger, Walter; Steger, Günther; Hofbauer, Friedrich; Samonigg, Hellmut; Gnant, Michael; Teleky, Bela; Kührer, Irene

    2015-08-01

    We investigated the hypothesis that the varying treatment efficacy of adjuvant 5-fluorouracil (5FU) in stage III colon cancer is linked to the TP53 mutational status. ABCSG-90 was a prospective randomized trial in which effect of adjuvant 5FU was studied in stage III colon cancer patients. Tumor material of 70% of these patients (389/572) was available for analysis of the biomarker TP53 using a TP53-gene-specific Sanger sequencing protocol. Median follow-up was 88 months. TP53 mutation frequency was 33%. A significant interaction between TP53 status, outcomes and nodal category was found (P = 0.0095). In the N1 category, TP53 wildtype patients had significantly better overall survival than TP53 mutated (81.0% vs. 62.0% overall survival at 5 years; HR = 2.131; 95% CI: 1.344-3.378; P = 0.0010). In the N2 category, the TP53 status did not affect survival (P = 0.4992). In TP53 wildtype patients, the prognostic significance of N category was significantly enhanced (P = 0.0002). In TP53 mutated patients, survival curves of N1 and N2 patients overlapped and nodal category was no longer prognostic. The biomarker TP53 independently predicted effect of adjuvant 5FU in N1 colon cancer patients. TP53 was not predictive in N2 patients, in whom 5FU is known to have no effect.

  13. Editorial Commentary: Single-Image Slice Magnetic Resonance Imaging Assessments Do Not Predict 3-Dimensional Muscle Volume.

    Science.gov (United States)

    Brand, Jefferson C

    2016-01-01

    No single-image magnetic resonance imaging (MRI) assessment-Goutallier classification, Fuchs classification, or cross-sectional area-is predictive of whole-muscle volume or fatty atrophy of the supraspinatus or infraspinatus. Rather, 3-dimensional MRI measurement of whole-muscle volume and fat-free muscle volume is required and is associated with shoulder strength, which is clinically relevant. Three-dimensional MRI may represent a new gold standard for assessment of the rotator cuff musculature using imaging and may help to predict the feasibility of repair of a rotator cuff tear as well as the postoperative outcome. Unfortunately, 3-dimensional MRI assessment of muscle volume is labor intensive and is not widely available for clinical use.

  14. An analytical model to predict the volume of sand during drilling and production

    Directory of Open Access Journals (Sweden)

    Raoof Gholami

    2016-08-01

    Full Text Available Sand production is an undesired phenomenon occurring in unconsolidated formations due to shear failure and hydrodynamic forces. There have been many approaches developed to predict sand production and prevent it by changing drilling or production strategies. However, assumptions involved in these approaches have limited their applications to very specific scenarios. In this paper, an elliptical model based on the borehole shape is presented to predict the volume of sand produced during the drilling and depletion stages of oil and gas reservoirs. A shape factor parameter is introduced to estimate the changes in the geometry of the borehole as a result of shear failure. A carbonate reservoir from the south of Iran with a solid production history is used to show the application of the developed methodology. Deriving mathematical equations for determination of the shape factor based on different failure criteria indicate that the effect of the intermediate principal stress should be taken into account to achieve an accurate result. However, it should be noticed that the methodology presented can only be used when geomechanical parameters are accurately estimated prior to the production stage when using wells and field data.

  15. An analytical model to predict the volume of sand during drilling and production

    Institute of Scientific and Technical Information of China (English)

    Raoof Gholami; Bernt Aadnoy; Vamegh Rasouli; Nikoo Fakhari

    2016-01-01

    Sand production is an undesired phenomenon occurring in unconsolidated formations due to shear failure and hydrodynamic forces. There have been many approaches developed to predict sand pro-duction and prevent it by changing drilling or production strategies. However, assumptions involved in these approaches have limited their applications to very specific scenarios. In this paper, an elliptical model based on the borehole shape is presented to predict the volume of sand produced during the drilling and depletion stages of oil and gas reservoirs. A shape factor parameter is introduced to estimate the changes in the geometry of the borehole as a result of shear failure. A carbonate reservoir from the south of Iran with a solid production history is used to show the application of the developed meth-odology. Deriving mathematical equations for determination of the shape factor based on different failure criteria indicate that the effect of the intermediate principal stress should be taken into account to achieve an accurate result. However, it should be noticed that the methodology presented can only be used when geomechanical parameters are accurately estimated prior to the production stage when using wells and field data.

  16. Field Surveys, IOC Valleys. Volume III, Part II. Cultural Resources Survey, Pine and Wah Wah Valleys, Utah.

    Science.gov (United States)

    1981-08-01

    including horse, camel, mammoth, Ertm E-TR-48-III-II 20 musk ox, and certain species of bison, goat, and bear, which had previously inhabited the marsh and...34 - - -9,$.. 𔄃 Im I I I Si to * Location lype/Contents Affiliation 42B@644 rid e over cr ek - P/J depression, cleared areas, Fr elon (f4-5-18-92) ground

  17. Survey of fish impingement at power plants in the United States. Volume III. Estuaries and coastal waters

    Energy Technology Data Exchange (ETDEWEB)

    Stupka, Richard C.; Sharma, Rajendra K.

    1977-03-01

    Impingement of fish at cooling-water intakes of 32 power plants, located on estuaries and coastal waters has been surveyed and data are presented. Descriptions of site, plant, and intake design and operation are provided. Reports in this volume summarize impingement data for individual plants in tabular and histogram formats. Information was available from differing sources such as the utilities themselves, public documents, regulatory agencies, and others. Thus, the extent of detail in the reports varies greatly from plant to plant. Histogram preparation involved an extrapolation procedure that has inadequacies. The reader is cautioned in the use of information presented in this volume to determine intake-design acceptability or intensity of impacts on ecosystems. No conclusions are presented herein; data comparisons are made in Volume IV.

  18. Broadband Fan Noise Prediction System for Turbofan Engines. Volume 2; BFaNS User's Manual and Developer's Guide

    Science.gov (United States)

    Morin, Bruce L.

    2010-01-01

    Pratt & Whitney has developed a Broadband Fan Noise Prediction System (BFaNS) for turbofan engines. This system computes the noise generated by turbulence impinging on the leading edges of the fan and fan exit guide vane, and noise generated by boundary-layer turbulence passing over the fan trailing edge. BFaNS has been validated on three fan rigs that were tested during the NASA Advanced Subsonic Technology Program (AST). The predicted noise spectra agreed well with measured data. The predicted effects of fan speed, vane count, and vane sweep also agreed well with measurements. The noise prediction system consists of two computer programs: Setup_BFaNS and BFaNS. Setup_BFaNS converts user-specified geometry and flow-field information into a BFaNS input file. From this input file, BFaNS computes the inlet and aft broadband sound power spectra generated by the fan and FEGV. The output file from BFaNS contains the inlet, aft and total sound power spectra from each noise source. This report is the second volume of a three-volume set documenting the Broadband Fan Noise Prediction System: Volume 1: Setup_BFaNS User s Manual and Developer s Guide; Volume 2: BFaNS User s Manual and Developer s Guide; and Volume 3: Validation and Test Cases. The present volume begins with an overview of the Broadband Fan Noise Prediction System, followed by step-by-step instructions for installing and running BFaNS. It concludes with technical documentation of the BFaNS computer program.

  19. Broadband Fan Noise Prediction System for Turbofan Engines. Volume 1; Setup_BFaNS User's Manual and Developer's Guide

    Science.gov (United States)

    Morin, Bruce L.

    2010-01-01

    Pratt & Whitney has developed a Broadband Fan Noise Prediction System (BFaNS) for turbofan engines. This system computes the noise generated by turbulence impinging on the leading edges of the fan and fan exit guide vane, and noise generated by boundary-layer turbulence passing over the fan trailing edge. BFaNS has been validated on three fan rigs that were tested during the NASA Advanced Subsonic Technology Program (AST). The predicted noise spectra agreed well with measured data. The predicted effects of fan speed, vane count, and vane sweep also agreed well with measurements. The noise prediction system consists of two computer programs: Setup_BFaNS and BFaNS. Setup_BFaNS converts user-specified geometry and flow-field information into a BFaNS input file. From this input file, BFaNS computes the inlet and aft broadband sound power spectra generated by the fan and FEGV. The output file from BFaNS contains the inlet, aft and total sound power spectra from each noise source. This report is the first volume of a three-volume set documenting the Broadband Fan Noise Prediction System: Volume 1: Setup_BFaNS User s Manual and Developer s Guide; Volume 2: BFaNS User's Manual and Developer s Guide; and Volume 3: Validation and Test Cases. The present volume begins with an overview of the Broadband Fan Noise Prediction System, followed by step-by-step instructions for installing and running Setup_BFaNS. It concludes with technical documentation of the Setup_BFaNS computer program.

  20. Validation that Metabolic Tumor Volume Predicts Outcome in Head-and-Neck Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Chad; Murphy, James D.; Khong, Brian; La, Trang H. [Department of Radiation Oncology, Stanford University, Stanford, CA (United States); Kong, Christina [Department of Pathology, Stanford University, Stanford, CA (United States); Fischbein, Nancy J. [Department of Radiology, Stanford University, Stanford, CA (United States); Colevas, A. Dimitrios [Division of Medical Oncology, Department of Medicine, Stanford University, Stanford, CA (United States); Iagaru, Andrei H. [Department of Radiology, Stanford University, Stanford, CA (United States); Graves, Edward E.; Loo, Billy W. [Department of Radiation Oncology, Stanford University, Stanford, CA (United States); Le, Quynh-Thu, E-mail: qle@stanford.edu [Department of Radiation Oncology, Stanford University, Stanford, CA (United States)

    2012-08-01

    Purpose: We have previously reported that metabolic tumor volume (MTV) obtained from pretreatment {sup 18}F-fluorodeoxydeglucose positron emission tomography (FDG PET)/ computed tomography (CT) predicted outcome in patients with head-and-neck cancer (HNC). The purpose of this study was to validate these results on an independent dataset, determine whether the primary tumor or nodal MTV drives this correlation, and explore the interaction with p16{sup INK4a} status as a surrogate marker for human papillomavirus (HPV). Methods and Materials: The validation dataset in this study included 83 patients with squamous cell HNC who had a FDG PET/CT scan before receiving definitive radiotherapy. MTV and maximum standardized uptake value (SUV{sub max}) were calculated for the primary tumor, the involved nodes, and the combination of both. The primary endpoint was to validate that MTV predicted progression-free survival and overall survival. Secondary analyses included determining the prognostic utility of primary tumor vs. nodal MTV. Results: Similarly to our prior findings, an increase in total MTV of 17 cm{sup 3} (difference between the 75th and 25th percentiles) was associated with a 2.1-fold increase in the risk of disease progression (p = 0.0002) and a 2.0-fold increase in the risk of death (p = 0.0048). SUV{sub max} was not associated with either outcome. Primary tumor MTV predicted progression-free (hazard ratio [HR] = 1.94; p < 0.0001) and overall (HR = 1.57; p < 0.0001) survival, whereas nodal MTV did not. In addition, MTV predicted progression-free (HR = 4.23; p < 0.0001) and overall (HR = 3.21; p = 0.0029) survival in patients with p16{sup INK4a}-positive oropharyngeal cancer. Conclusions: This study validates our previous findings that MTV independently predicts outcomes in HNC. MTV should be considered as a potential risk-stratifying biomarker in future studies of HNC.

  1. A new model to predict weak-lensing peak counts III. Filtering technique comparisons

    CERN Document Server

    Lin, Chieh-An; Pires, Sandrine

    2016-01-01

    This is the third in a series of papers that develop a new and flexible model to predict weak-lensing (WL) peak counts, which have been shown to be a very valuable non-Gaussian probe of cosmology. In this paper, we compare the cosmological information extracted from WL peak counts using different filtering techniques of the galaxy shear data, including linear filtering with a Gaussian and two compensated filters (the starlet wavelet and the aperture mass), and the nonlinear filtering method MRLens. We present improvements to our model that account for realistic survey conditions, which are masks, shear-to-convergence transformations, and non-constant noise. We create simulated peak counts from our stochastic model, from which we obtain constraints on the matter density $\\Omega_\\mathrm{m}$, the power spectrum normalization $\\sigma_8$, and the dark-energy parameter $w_0^\\mathrm{de}$. We use two methods for parameter inference, a copula likelihood, and approximate Bayesian computation (ABC). We measure the conto...

  2. An Evaluation of the Mulligan Stew 4-H Television Series for Extension Service, USDA. Volume III: Case Studies.

    Science.gov (United States)

    Abt Associates, Inc., Cambridge, MA.

    Conducted on over 3,000 fourth, fifth, and sixth grade children in six states, this study documents changes in nutrition-related knowledge and behaviors which can be related to participating in the Mulligan Stew television series. The case studies which comprise this volume function as a brief organizational analysis of the Mulligan Stew effort at…

  3. International conference on high-energy physics. Volume 1. Sessions I to III. [Geneva, June 27-July 4, 1979

    Energy Technology Data Exchange (ETDEWEB)

    1980-02-01

    Volume 1 of the conference proceedings contains sessions on neutrino physics and weak interactions, e/sup +/e/sup -/ physics, and theory. Five of the papers have already been cited in ERA, and can be found by reference to the entry CONF-790642-- in the Report Number Index. The remaining 30 will be processed as they are received on the Atomindex tape. (RWR)

  4. Failure mode analysis for lime/limestone FGD system. Volume III. Plant profiles. Part 1 of 3

    Energy Technology Data Exchange (ETDEWEB)

    Kenney, S.M.; Rosenberg, H.S.; Nilsson, L.I.O.; Oxley, J.H.

    1984-08-01

    This volume contains plant profiles for: Petersburg 3; Hawthorn 3, 4; La Cygne 1; Jeffry 1, 2; Lawrence 4, 5; Green River 1-3; Cane Run 4, 5; Mill Creek 1, 3; Paddy's Run 6; Clay Boswell 4; Milton R. Young 2; Pleasants 1, 2; and Colstrip 1, 2. (DLC)

  5. Contemporary American Success Stories: Famous People of Hispanic Heritage. Volume III. A Mitchell Lane Multicultural Biography Series.

    Science.gov (United States)

    Marvis, Barbara J.

    The biographies in this projected eight volume series for elementary school children represent the diversity of Hispanic heritage in the United States. Those featured are contemporary figures with national origins in the United States or Latin America, with careers that cover many aspects of contemporary life. Every person profiled in the series…

  6. Inventory of Federal energy-related environment and safety research for FY 1977. Volume III. Interactive terminal users guide

    Energy Technology Data Exchange (ETDEWEB)

    Shriner, C.R.; Peck, L.J.; Miller, C.E.

    1978-07-01

    This users guide was prepared to provide interested persons access to, via computer terminals, federally funded energy-related environment and safety research projects for FY 1977. Although this information is also available in hardbound volumes, this on-line searching capability is expected to reduce the time required to answer ad hoc questions and, at the same time, produce meaningful reports.

  7. Sonographic Prediction of Body Fat Volume (Subcutaneous and Visceral Fat in Cardiovascular Patients

    Directory of Open Access Journals (Sweden)

    Maryam Soleymanzadeh

    2010-05-01

    Full Text Available Background: Inappropriate body composition represents impaired energy and nutrient intake and can be a risk factor for many diseases, especially for cardiovascular disease. Different methods have been suggested for the estimation of body fat volume and its distribution. However, they may be either expensive or hazardous for some groups of patients. Sonography is a very accessible technique, which may be used for the evaluation of visceral and subcutaneous fat volume. The purpose of this study was to evaluate the sonographic prediction of body fat and its distribution in subcutaneous and visceral compartments.Methods: During a three-month period, we conducted sonographic evaluations for visceral and subcutaneous fat in 106 patients who were admitted to our hospital. The subcutaneous fat was measured at the para-umbilical region and visceral fat was measured in the right para-renal space. The results were compared with the data obtained from the body mass index(BMI and bioelectric impedance analysis.Results: The mean age of the patients was 58.8 years, and the mean BMI was26.48 ± 0.33. The mean values of fat percent and fat mass obtained by the electric-method were 31.07 ± 0.81% and 22.12 ± 0.68 kg, respectively. The respective mean values of subcutaneous and visceral fat obtained by sonography were 20.50±0.56 mm and 24.14 ± 0.58 mm. The correlationbetween BMI and subcutaneous fat was 0.85 (p value < 0.0001 and the correlation between BMI and visceral fat was0.46(p value < 0.0001.Conclusion: Sonography is a reliable and available method for the estimation of body fat and its distribution in cardiovascularpatients, in subcutaneous and visceral compartments.

  8. Applying dynamic parameters to predict hemodynamic response to volume expansion in spontaneously breathing patients with septic shock.

    Science.gov (United States)

    Lanspa, Michael J; Grissom, Colin K; Hirshberg, Eliotte L; Jones, Jason P; Brown, Samuel M

    2013-02-01

    Volume expansion is a mainstay of therapy in septic shock, although its effect is difficult to predict using conventional measurements. Dynamic parameters, which vary with respiratory changes, appear to predict hemodynamic response to fluid challenge in mechanically ventilated, paralyzed patients. Whether they predict response in patients who are free from mechanical ventilation is unknown. We hypothesized that dynamic parameters would be predictive in patients not receiving mechanical ventilation. This is a prospective, observational, pilot study. Patients with early septic shock and who were not receiving mechanical ventilation received 10-mL/kg volume expansion (VE) at their treating physician's discretion after initial resuscitation in the emergency department. We used transthoracic echocardiography to measure vena cava collapsibility index and aortic velocity variation before VE. We used a pulse contour analysis device to measure stroke volume variation (SVV). Cardiac index was measured immediately before and after VE using transthoracic echocardiography. Hemodynamic response was defined as an increase in cardiac index 15% or greater. Fourteen patients received VE, five of whom demonstrated a hemodynamic response. Vena cava collapsibility index and SVV were predictive (area under the curve = 0.83, 0.92, respectively). Optimal thresholds were calculated: vena cava collapsibility index, 15% or greater (positive predictive value, 62%; negative predictive value, 100%; P = 0.03); SVV, 17% or greater (positive predictive value 100%, negative predictive value 82%, P = 0.03). Aortic velocity variation was not predictive. Vena cava collapsibility index and SVV predict hemodynamic response to fluid challenge patients with septic shock who are not mechanically ventilated. Optimal thresholds differ from those described in mechanically ventilated patients.

  9. Empirical models to predict the volumes of debris flows generated by recently burned basins in the western U.S.

    Science.gov (United States)

    Gartner, J.E.; Cannon, S.H.; Santi, P.M.; deWolfe, V.G.

    2008-01-01

    Recently burned basins frequently produce debris flows in response to moderate-to-severe rainfall. Post-fire hazard assessments of debris flows are most useful when they predict the volume of material that may flow out of a burned basin. This study develops a set of empirically-based models that predict potential volumes of wildfire-related debris flows in different regions and geologic settings. The models were developed using data from 53 recently burned basins in Colorado, Utah and California. The volumes of debris flows in these basins were determined by either measuring the volume of material eroded from the channels, or by estimating the amount of material removed from debris retention basins. For each basin, independent variables thought to affect the volume of the debris flow were determined. These variables include measures of basin morphology, basin areas burned at different severities, soil material properties, rock type, and rainfall amounts and intensities for storms triggering debris flows. Using these data, multiple regression analyses were used to create separate predictive models for volumes of debris flows generated by burned basins in six separate regions or settings, including the western U.S., southern California, the Rocky Mountain region, and basins underlain by sedimentary, metamorphic and granitic rocks. An evaluation of these models indicated that the best model (the Western U.S. model) explains 83% of the variability in the volumes of the debris flows, and includes variables that describe the basin area with slopes greater than or equal to 30%, the basin area burned at moderate and high severity, and total storm rainfall. This model was independently validated by comparing volumes of debris flows reported in the literature, to volumes estimated using the model. Eighty-seven percent of the reported volumes were within two residual standard errors of the volumes predicted using the model. This model is an improvement over previous models in

  10. A predictive genetic signature for response to fluoropyrimidine-based neoadjuvant chemoradiation in clinical Stage II and III rectal cancer

    Directory of Open Access Journals (Sweden)

    Jason eChan

    2013-11-01

    Full Text Available PurposePreoperative chemoradiation is currently the standard of care for patients with clinical stage II and III rectal cancer but only about 45% of patients achieve tumor downstaging and less than 20% of patients achieve a pathologic complete response. Better methods to stratify patients according to potential neoadjuvant treatment response are needed. We used microarray analysis to identify a genetic signature that correlates with a pathological complete response to neoadjuvant chemoradiation. We performed a gene network analysis to identify potential signaling pathways involved in determining response to neoadjuvant treatment.Patients and MethodsWe identified 31 T3-4 N0-1 rectal cancer patients who were treated with neoadjuvant fluorouracil-based chemoradiation. 8 patients were identified to have achieved a pathological complete response to treatment while 23 patients did not. mRNA expression was analyzed using cDNA microarrays. The correlation between mRNA expression and pathological complete response from pre-treatment tumor biopsies was determined. Gene network analysis was performed for the genes represented by the predictive signature.ResultsA genetic signature represented by expression levels of the 3 genes EHBP1, STAT1, and GAPDH was found to correlate with a pathological complete response to neoadjuvant treatment. The difference in expression levels between patients who achieved a pathological complete response and those who did not was greatest for EHBP1. Gene network analysis showed that the 3 genes can be connected by the gene UBC. ConclusionThis study identifies a 3-gene signature expressed in pre-treatment tumor biopsies that correlates with a pathological complete response to neoadjuvant chemoradiation in patients with clinical stage II and III rectal cancer. These 3 genes can be connected by the gene UBC, suggesting that ubiquination is a molecular mechanism involved in determining response to treatment. Validating this genet

  11. Long-term prediction of emergency department revenue and visitor volume using autoregressive integrated moving average model.

    Science.gov (United States)

    Chen, Chieh-Fan; Ho, Wen-Hsien; Chou, Huei-Yin; Yang, Shu-Mei; Chen, I-Te; Shi, Hon-Yi

    2011-01-01

    This study analyzed meteorological, clinical and economic factors in terms of their effects on monthly ED revenue and visitor volume. Monthly data from January 1, 2005 to September 30, 2009 were analyzed. Spearman correlation and cross-correlation analyses were performed to identify the correlation between each independent variable, ED revenue, and visitor volume. Autoregressive integrated moving average (ARIMA) model was used to quantify the relationship between each independent variable, ED revenue, and visitor volume. The accuracies were evaluated by comparing model forecasts to actual values with mean absolute percentage of error. Sensitivity of prediction errors to model training time was also evaluated. The ARIMA models indicated that mean maximum temperature, relative humidity, rainfall, non-trauma, and trauma visits may correlate positively with ED revenue, but mean minimum temperature may correlate negatively with ED revenue. Moreover, mean minimum temperature and stock market index fluctuation may correlate positively with trauma visitor volume. Mean maximum temperature, relative humidity and stock market index fluctuation may correlate positively with non-trauma visitor volume. Mean maximum temperature and relative humidity may correlate positively with pediatric visitor volume, but mean minimum temperature may correlate negatively with pediatric visitor volume. The model also performed well in forecasting revenue and visitor volume.

  12. Long-Term Prediction of Emergency Department Revenue and Visitor Volume Using Autoregressive Integrated Moving Average Model

    Directory of Open Access Journals (Sweden)

    Chieh-Fan Chen

    2011-01-01

    Full Text Available This study analyzed meteorological, clinical and economic factors in terms of their effects on monthly ED revenue and visitor volume. Monthly data from January 1, 2005 to September 30, 2009 were analyzed. Spearman correlation and cross-correlation analyses were performed to identify the correlation between each independent variable, ED revenue, and visitor volume. Autoregressive integrated moving average (ARIMA model was used to quantify the relationship between each independent variable, ED revenue, and visitor volume. The accuracies were evaluated by comparing model forecasts to actual values with mean absolute percentage of error. Sensitivity of prediction errors to model training time was also evaluated. The ARIMA models indicated that mean maximum temperature, relative humidity, rainfall, non-trauma, and trauma visits may correlate positively with ED revenue, but mean minimum temperature may correlate negatively with ED revenue. Moreover, mean minimum temperature and stock market index fluctuation may correlate positively with trauma visitor volume. Mean maximum temperature, relative humidity and stock market index fluctuation may correlate positively with non-trauma visitor volume. Mean maximum temperature and relative humidity may correlate positively with pediatric visitor volume, but mean minimum temperature may correlate negatively with pediatric visitor volume. The model also performed well in forecasting revenue and visitor volume.

  13. Predicting the film and lens water volume between soil particles using particle size distribution data

    Science.gov (United States)

    Mohammadi, M. H.; Meskini-Vishkaee, F.

    2012-12-01

    SummaryWe develop four conceptual approaches to quantify the volume of water lenses between soil particles (ɛi) and adsorbed water films (δi) coating soil particles based on soil Particle Size Distribution (PSD) data. Method 1 is based on expression of the ɛi as matric suction independent pendular rings and method 2 is based on expression of the ɛi as function of matric suction. Methods 3 and 4 are based on the coupling of δi estimated with van der Waals and electrostatic forces, with ɛi estimated with methods 1 and 2 respectively. We show that the filling angle of the lens water is independent of surface tension but increases with the porosity. The four methods are applied to predict effects of ɛi and δi on Soil Moisture Characteristics (SMC) in eighty soil samples selected from UNSODA database. The total component of the ɛi in soil water content ranged from 0.0111 (L3 L-3) to 0.1604 (L3 L-3), with the average of 0.0703 (L3 L-3) for method 1 and from 0.0082 (L3 L-3) to 0.0523 (L3 L-3), with the average of 0.0237 (L3 L-3) for method 2. The component of δi is less than 0.0121 of each pore water content. Results showed that for methods 1 and 2, the component of the ɛi in the soil water content was partially relevant for the prediction of SMC, especially in dry range. Moreover, the accuracy of the method 1 was slightly greater than that of the method 2. We attribute the methods error to the roughness of soil particles, high surface energy content of clay particles and, to the simplified pore geometric concepts that does not effectively reflect the pore geometry. We conclude that the main advantage of the present approaches is developing two different methods for estimation of the volume of the lens water by using only the PSD data and bulk density which are measured easily.

  14. Florence Richardson Wyckoff (1905-1997), Fifty Years of Grassroots Social ActivismVolume III: Watsonville Years 1960-1985

    OpenAIRE

    1990-01-01

    Florence Wyckoff's three-volume oral history documents her remarkable, lifelong work as a social activist, during which she has become nationally recognized as an advocate of migrant families and children. From the depression years through the 1970s, she pursued grassroots, democratic, community-building efforts in the service of improving public health standards and providing health care, education, and housing for migrant families. Major legislative milestones in her career of advocacy were...

  15. West Hackberry Strategic Petroleum Reserve site brine-disposal monitoring, Year I report. Volume III. Biological oceanography. Final report

    Energy Technology Data Exchange (ETDEWEB)

    DeRouen, L.R.; Hann, R.W.; Casserly, D.M.; Giammona, C.; Lascara, V.J. (eds.)

    1983-02-01

    The Department of Energy's Strategic Petroleum Reserve Program began discharging brine into the Gulf of Mexico from its West Hackberry site near Cameron, Louisiana in May 1981. The brine originates from underground salt domes being leached with water from the Intracoastal Waterway, making available vast underground storage caverns for crude oil. The effects of brine discharge on aquatic organisms are presented in this volume. The topics covered are: benthos; nekton; phytoplankton; zooplankton; and data management.

  16. The Natural History and Predictive Factors of Voided Volume in Older Men : The Krimpen Study

    NARCIS (Netherlands)

    van Doorn, Boris; Kok, Esther T.; Blanker, Marco H.; Martens, Edwin P.; Bohnen, Arthur M.; Bosch, J. L. H. Ruud

    Purpose: Although functional bladder capacity, as expressed by maximum voided volume and other frequency-volume chart parameters, are important determinants of lower urinary tract symptoms, to our knowledge no population based data are available on changes in voided volume. We determined changes in

  17. Predicting traffic volumes and estimating the effects of shocks in massive transportation systems.

    Science.gov (United States)

    Silva, Ricardo; Kang, Soong Moon; Airoldi, Edoardo M

    2015-05-05

    Public transportation systems are an essential component of major cities. The widespread use of smart cards for automated fare collection in these systems offers a unique opportunity to understand passenger behavior at a massive scale. In this study, we use network-wide data obtained from smart cards in the London transport system to predict future traffic volumes, and to estimate the effects of disruptions due to unplanned closures of stations or lines. Disruptions, or shocks, force passengers to make different decisions concerning which stations to enter or exit. We describe how these changes in passenger behavior lead to possible overcrowding and model how stations will be affected by given disruptions. This information can then be used to mitigate the effects of these shocks because transport authorities may prepare in advance alternative solutions such as additional buses near the most affected stations. We describe statistical methods that leverage the large amount of smart-card data collected under the natural state of the system, where no shocks take place, as variables that are indicative of behavior under disruptions. We find that features extracted from the natural regime data can be successfully exploited to describe different disruption regimes, and that our framework can be used as a general tool for any similar complex transportation system.

  18. Impact erosion prediction using the finite volume particle method with improved constitutive models

    Science.gov (United States)

    Leguizamón, Sebastián; Jahanbakhsh, Ebrahim; Maertens, Audrey; Vessaz, Christian; Alimirzazadeh, Siamak; Avellan, François

    2016-11-01

    Erosion damage in hydraulic turbines is a common problem caused by the high- velocity impact of small particles entrained in the fluid. In this investigation, the Finite Volume Particle Method is used to simulate the three-dimensional impact of rigid spherical particles on a metallic surface. Three different constitutive models are compared: the linear strainhardening (L-H), Cowper-Symonds (C-S) and Johnson-Cook (J-C) models. They are assessed in terms of the predicted erosion rate and its dependence on impact angle and velocity, as compared to experimental data. It has been shown that a model accounting for strain rate is necessary, since the response of the material is significantly tougher at the very high strain rate regime caused by impacts. High sensitivity to the friction coefficient, which models the cutting wear mechanism, has been noticed. The J-C damage model also shows a high sensitivity to the parameter related to triaxiality, whose calibration appears to be scale-dependent, not exclusively material-determined. After calibration, the J-C model is capable of capturing the material's erosion response to both impact velocity and angle, whereas both C-S and L-H fail.

  19. Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery

    Directory of Open Access Journals (Sweden)

    DeMeo Dawn L

    2007-08-01

    Full Text Available Abstract Background In the National Emphysema Treatment Trial (NETT, marked variability in response to lung volume reduction surgery (LVRS was observed. We sought to identify genetic differences which may explain some of this variability. Methods In 203 subjects from the NETT Genetics Ancillary Study, four outcome measures were used to define response to LVRS at six months: modified BODE index, post-bronchodilator FEV1, maximum work achieved on a cardiopulmonary exercise test, and University of California, San Diego shortness of breath questionnaire. Sixty-four single nucleotide polymorphisms (SNPs were genotyped in five genes previously shown to be associated with chronic obstructive pulmonary disease susceptibility, exercise capacity, or emphysema distribution. Results A SNP upstream from glutathione S-transferase pi (GSTP1; p = 0.003 and a coding SNP in microsomal epoxide hydrolase (EPHX1; p = 0.02 were each associated with change in BODE score. These effects appeared to be strongest in patients in the non-upper lobe predominant, low exercise subgroup. A promoter SNP in EPHX1 was associated with change in BODE score (p = 0.008, with the strongest effects in patients with upper lobe predominant emphysema and low exercise capacity. One additional SNP in GSTP1 and three additional SNPs in EPHX1 were associated (p Conclusion Genetic variants in GSTP1 and EPHX1, two genes encoding xenobiotic metabolizing enzymes, were predictive of response to LVRS. These polymorphisms may identify patients most likely to benefit from LVRS.

  20. Stroke volume variation does not predict fluid responsiveness in patients with septic shock on pressure support ventilation

    DEFF Research Database (Denmark)

    Perner, A; Faber, T

    2006-01-01

    Stroke volume variation (SVV)--as measured by the pulse contour cardiac output (PiCCO) system--predicts the cardiac output response to a fluid challenge in patients on controlled ventilation. Whether this applies to patients on pressure support ventilation is unknown....

  1. Prediction of Currency Volume Issued in Taiwan Using a Hybrid Artificial Neural Network and Multiple Regression Approach

    Directory of Open Access Journals (Sweden)

    Yuehjen E. Shao

    2013-01-01

    Full Text Available Because the volume of currency issued by a country always affects its interest rate, price index, income levels, and many other important macroeconomic variables, the prediction of currency volume issued has attracted considerable attention in recent years. In contrast to the typical single-stage forecast model, this study proposes a hybrid forecasting approach to predict the volume of currency issued in Taiwan. The proposed hybrid models consist of artificial neural network (ANN and multiple regression (MR components. The MR component of the hybrid models is established for a selection of fewer explanatory variables, wherein the selected variables are of higher importance. The ANN component is then designed to generate forecasts based on those important explanatory variables. Subsequently, the model is used to analyze a real dataset of Taiwan's currency from 1996 to 2011 and twenty associated explanatory variables. The prediction results reveal that the proposed hybrid scheme exhibits superior forecasting performance for predicting the volume of currency issued in Taiwan.

  2. A principal component approach for predicting the stem volume in Eucalyptus plantations in Brazil using airborne LiDAR data

    Science.gov (United States)

    Carlos Alberto Silva; Carine Klauberg; Andrew T. Hudak; Lee A. Vierling; Veraldo Liesenberg; Samuel P. C. e Carvalho; Luiz C. E. Rodriguez

    2016-01-01

    Improving management practices in industrial forest plantations may increase production efficiencies, thereby reducing pressures on native tropical forests for meeting global pulp needs. This study aims to predict stem volume (V) in plantations of fast-growing Eucalyptus hybrid clones located in southeast Brazil using field plot and airborne Light Detection...

  3. Absence of TGF-βRII predicts bone and lung metastasis and is associated with poor prognosis in stage III breast tumors

    DEFF Research Database (Denmark)

    Paiva, Carlos Eduardo; Serrano, Sérgio Vicente; Paiva, Bianca Sakamoto Ribeiro

    2012-01-01

    of TGF-βRII in BC samples. TGF-βRII protein expression was evaluated using immunohistochemistry on a tissue microarray containing 110 TNM stage III BC samples obtained prior to doxorubicin-based neoadjuvant chemotherapy (NAC). Our results demonstrate that TGF-βRII did not predict the response to NAC...

  4. Applying dynamic parameters to predict hemodynamic response to volume expansion in spontaneously breathing patients with septic shock

    Science.gov (United States)

    Lanspa, Michael J.; Grissom, Colin K.; Hirshberg, Eliotte L.; Jones, Jason P.; Brown, Samuel M.

    2013-01-01

    Background Volume expansion is a mainstay of therapy in septic shock, although its effect is difficult to predict using conventional measurements. Dynamic parameters, which vary with respiratory changes, appear to predict hemodynamic response to fluid challenge in mechanically ventilated, paralyzed patients. Whether they predict response in patients who are free from mechanical ventilation is unknown. We hypothesized that dynamic parameters would be predictive in patients not receiving mechanical ventilation. Methods This is a prospective, observational, pilot study. Patients with early septic shock and who were not receiving mechanical ventilation received 10 ml/kg volume expansion (VE) at their treating physician's discretion after initial resuscitation in the emergency department. We used transthoracic echocardiography to measure vena cava collapsibility index (VCCI) and aortic velocity variation (AoVV) prior to VE. We used a pulse contour analysis device to measure stroke volume variation (SVV). Cardiac index was measured immediately before and after VE using transthoracic echocardiography. Hemodynamic response was defined as an increase in cardiac index ≥ 15%. Results 14 patients received VE, 5 of which demonstrated a hemodynamic response. VCCI and SVV were predictive (Area under curve = 0.83, 0.92, respectively). Optimal thresholds were calculated: VCCI ≥ 15% (Positive predictive value, PPV 62%, negative predictive value, NPV 100%, p = 0.03); SVV ≥ 17% (PPV 100%, NPV 82%, p = 0.03). AoVV was not predictive. Conclusions VCCI and SVV predict hemodynamic response to fluid challenge patients with septic shock who are not mechanically ventilated. Optimal thresholds differ from those described in mechanically ventilated patients. PMID:23324885

  5. Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study.

    Science.gov (United States)

    Dienstmann, R; Mason, M J; Sinicrope, F A; Phipps, A I; Tejpar, S; Nesbakken, A; Danielsen, S A; Sveen, A; Buchanan, D D; Clendenning, M; Rosty, C; Bot, B; Alberts, S R; Milburn Jessup, J; Lothe, R A; Delorenzi, M; Newcomb, P A; Sargent, D; Guinney, J

    2017-05-01

    TNM staging alone does not accurately predict outcome in colon cancer (CC) patients who may be eligible for adjuvant chemotherapy. It is unknown to what extent the molecular markers microsatellite instability (MSI) and mutations in BRAF or KRAS improve prognostic estimation in multivariable models that include detailed clinicopathological annotation. After imputation of missing at random data, a subset of patients accrued in phase 3 trials with adjuvant chemotherapy (n = 3016)-N0147 (NCT00079274) and PETACC3 (NCT00026273)-was aggregated to construct multivariable Cox models for 5-year overall survival that were subsequently validated internally in the remaining clinical trial samples (n = 1499), and also externally in different population cohorts of chemotherapy-treated (n = 949) or -untreated (n = 1080) CC patients, and an additional series without treatment annotation (n = 782). TNM staging, MSI and BRAFV600E mutation status remained independent prognostic factors in multivariable models across clinical trials cohorts and observational studies. Concordance indices increased from 0.61-0.68 in the TNM alone model to 0.63-0.71 in models with added molecular markers, 0.65-0.73 with clinicopathological features and 0.66-0.74 with all covariates. In validation cohorts with complete annotation, the integrated time-dependent AUC rose from 0.64 for the TNM alone model to 0.67 for models that included clinicopathological features, with or without molecular markers. In patient cohorts that received adjuvant chemotherapy, the relative proportion of variance explained (R2) by TNM, clinicopathological features and molecular markers was on an average 65%, 25% and 10%, respectively. Incorporation of MSI, BRAFV600E and KRAS mutation status to overall survival models with TNM staging improves the ability to precisely prognosticate in stage II and III CC patients, but only modestly increases prediction accuracy in multivariable models that include

  6. A lymph node ratio of 10% is predictive of survival in stage III colon cancer: a French regional study.

    Science.gov (United States)

    Sabbagh, Charles; Mauvais, François; Cosse, Cyril; Rebibo, Lionel; Joly, Jean-Paul; Dromer, Didier; Aubert, Christine; Carton, Sophie; Dron, Bernard; Dadamessi, Innocenti; Maes, Bernard; Perrier, Guillaume; Manaouil, David; Fontaine, Jean-François; Gozy, Michel; Panis, Xavier; Foncelle, Pierre Henri; de Fresnoy, Hugues; Leroux, Fabien; Vaneslander, Pierre; Ghighi, Caroline; Regimbeau, Jean-Marc

    2014-01-01

    Lymph node ratio (LNR) (positive lymph nodes/sampled lymph nodes) is predictive of survival in colon cancer. The aim of the present study was to validate the LNR as a prognostic factor and to determine the optimum LNR cutoff for distinguishing between "good prognosis" and "poor prognosis" colon cancer patients. From January 2003 to December 2007, patients with TNM stage III colon cancer operated on with at least of 3 years of follow-up and not lost to follow-up were included in this retrospective study. The two primary endpoints were 3-year overall survival (OS) and disease-free survival (DFS) as a function of the LNR groups and the cutoff. One hundred seventy-eight patients were included. There was no correlation between the LNR group and 3-year OS (P=0.06) and a significant correlation between the LNR group and 3-year DFS (P=0.03). The optimal LNR cutoff of 10% was significantly correlated with 3-year OS (P=0.02) and DFS (P=0.02). The LNR was not an accurate prognostic factor when fewer than 12 lymph nodes were sampled. Clarification and simplification of the LNR classification are prerequisites for use of this system in randomized control trials. An LNR of 10% appears to be the optimal cutoff.

  7. CXC chemokine receptor 1 predicts postoperative prognosis and chemotherapeutic benefits for TNM II and III resectable gastric cancer patients.

    Science.gov (United States)

    Cao, Yifan; Liu, Hao; Zhang, Heng; Lin, Chao; Li, Ruochen; Wu, Songyang; Li, He; He, Hongyong; Zhang, Weijuan; Xu, Jiejie

    2017-03-21

    Backround: Abnormal expression of CXC chemokine receptor 1 (CXCR1) has shown the ability to promote tumor angiogensis, invasion and metastasis in several cancers. The purpose of our curret study is to discover the clinical prognostic significance of CXCR1 in resectable gastric cancer. 330 gastric cancer patients who underwent R0 gastrectomy with standard D2 lymphadenectomy at Zhongshan Hospital, Fudan University between 2007 and 2008 were enrolled. CXCR1 expression was evaluated with use of immunohistochemical staining. The relation between CXCR1 expression and clinicopathological features and postoperative prognosis was respectively inspected. In both discovery and validation data sets, CXCR1 high expression indicated poorer overall survival (OS) in TNM II and III patients. Furthermore, multivariate analysis identified CXCR1 expression and TNM stage as two independent prognostic factors for OS. Incorporating CXCR1 expression into current TNM staging system could generate a novel clinical predictive model for gastric cancer, showing better prognostic accuracy with respect to patients' OS. More importantly, TNM II patients with higher CXCR1 expression were shown to significantly benefit from postoperative 5-fluorouracil (5-FU) based adjuvant chemotherapy (ACT). CXCR1 in gastric cancer was identified as an independent adverse prognostic factor. Combining CXCR1 expression with current TNM staging system could lead to better risk stratification and more accurate prognosis for gastric cancer patients. High expression of CXCR1 identified a subgroup of TNM stage II gastric cancer patients who appeared to benefit from 5-FU based ACT.

  8. Transport of solid commodities via freight pipeline: cost estimating methodology. Volume III, parts A and B. First year final report

    Energy Technology Data Exchange (ETDEWEB)

    Warner, J.A.; Morlok, E.K.; Gimm, K.K.; Zandi, I.

    1976-07-01

    In order to examine the feasibility of an intercity freight pipeline, it was necessary to develop cost equations for various competing transportation modes. This volume presents cost-estimating equations for rail carload, trailer-on-flatcar, truck, and freight pipeline. Section A presents mathematical equations that approximate the fully allocated and variable costs contained in the ICC cost tables for rail carload, trailer-on-flatcar (TOFC) and truck common-carrier intercity freight movements. These equations were developed to enable the user to approximate the ICC costs quickly and easily. They should find use in initial studies of costs where exact values are not needed, such as in consideration of rate changes, studies of profitability, and in general inter-modal comparisons. Section B discusses the development of a set of engineering cost equations for pneumo-capsule pipelines. The development was based on an analysis of system components and can readily be extended to other types of pipeline. The model was developed for the purpose of a feasibility study. It employs a limited number of generalized parameters and its use is recommended when sufficient detailed and specific engineering information is lacking. These models were used in the comparison of modes presented in Volume I and hence no conclusions regarding relative costs or service of the modes are presented here. The primary conclusion is that the estimates of costs resulting from these models is subject to considerable uncertainty.

  9. Resonant frequency does not predict high-frequency chest compression settings that maximize airflow or volume.

    Science.gov (United States)

    Luthy, Sarah K; Marinkovic, Aleksandar; Weiner, Daniel J

    2011-06-01

    High-frequency chest compression (HFCC) is a therapy for cystic fibrosis (CF). We hypothesized that the resonant frequency (f(res)), as measured by impulse oscillometry, could be used to determine what HFCC vest settings produce maximal airflow or volume in pediatric CF patients. In 45 subjects, we studied: f(res), HFCC vest frequencies that subjects used (f(used)), and the HFCC vest frequencies that generated the greatest volume (f(vol)) and airflow (f(flow)) changes as measured by pneumotachometer. Median f(used) for 32 subjects was 14 Hz (range, 6-30). The rank order of the three most common f(used) was 15 Hz (28%) and 12 Hz (21%); three frequencies tied for third: 10, 11, and 14 Hz (5% each). Median f(res) for 43 subjects was 20.30 Hz (range, 7.85-33.65). Nineteen subjects underwent vest-tuning to determine f(vol) and f(flow). Median f(vol) was 8 Hz (range, 6-30). The rank order of the three most common f(vol) was: 8 Hz (42%), 6 Hz (32%), and 10 Hz (21%). Median f(flow) was 26 Hz (range, 8-30). The rank order of the three most common f(flow) was: 30 Hz (26%) and 28 Hz (21%); three frequencies tied for third: 8, 14, and 18 Hz (11% each). There was no correlation between f(used) and f(flow) (r(2)  = -0.12) or f(vol) (r(2) = 0.031). There was no correlation between f(res) and f(flow) (r(2)  = 0.19) or f(vol) (r(2) = 0.023). Multivariable analysis showed no independent variables were predictive of f(flow) or f(vol). Vest-tuning may be required to optimize clinical utility of HFCC. Multiple HFCC frequencies may need to be used to incorporate f(flow) and f(vol).

  10. Prediction method for the volume of the excess post-exercise oxygen consumption (EPOC) following supramaximal exercise.

    Science.gov (United States)

    Stefanova, D

    2000-01-01

    Short (up to 60 s) supramaximal (about 400 W on the average) exercise is accompanied by specific biochemical processes in the working muscles and by a general increase in energy metabolism. Outwardly, this is manifested by an excess post-exercise oxygen consumption (EPOC). Since its actual measurement is time consuming and associated sometimes with difficulties, we propose a fixed 3-min test for EPOC prediction. The measured volumes of oxygen consumption are related to the corresponding periods in a coordinate system as reciprocal values. The linear equation, whose parameters were calculated by the method of least squares or were determined graphically, provided for prediction of the EPOC volume with satisfactory accuracy and precision. The obtained increase of the predicted values over the actually measured values was below 5%, and the correlation coefficient r = 0.98. Other parameters of the recovery process were also calculated, such as tau (half-time) of EPOC and the rate constant k.

  11. Stroke volume variation compared with pulse pressure variation and cardiac index changes for prediction of fluid responsiveness in mechanically ventilated patients

    Directory of Open Access Journals (Sweden)

    Randa Aly Soliman

    2015-04-01

    Conclusions: Baseline stroke volume variation ⩾8.15% predicted fluid responsiveness in mechanically ventilated patients with acute circulatory failure. The study also confirmed the ability of pulse pressure variation to predict fluid responsiveness.

  12. High-Volume Transanal Surgery with CPH34 HV for the Treatment of III-IV Degree Haemorrhoids: Final Short-Term Results of an Italian Multicenter Clinical Study

    Directory of Open Access Journals (Sweden)

    Giuliano Reboa

    2016-01-01

    Full Text Available The clinical chart of 621 patients with III-IV haemorrhoids undergoing Stapled Hemorrhoidopexy (SH with CPH34 HV in 2012–2014 was consecutively reviewed to assess its safety and efficacy after at least 12 months of follow-up. Mean volume of prolapsectomy was significantly higher (13.0 mL; SD, 1.4 in larger prolapse (9.3 mL; SD, 1.2 (p<0.001. Residual or recurrent haemorrhoids occurred in 11 of 621 patients (1.8% and in 12 of 581 patients (1.9%, respectively. Relapse was correlated with higher preoperative Constipation Scoring System (CSS (p=0.000, Pescatori’s degree (p=0.000, Goligher’s grade (p=0.003, prolapse exceeding half of the length of the Circular Anal Dilator (CAD (p=0.000, and higher volume of prolapsectomy (p=0.000. At regression analysis, only the preoperative CSS, Pescatori’s degree, Goligher’s grade, and volume of resection were significantly predictive of relapse. A high level of satisfaction (VAS = 8.6; SD, 1.0 coupled with a reduction of 12-month CSS (Δ preoperative CSS/12 mo CSS = 3.4, SD, 2.0; p<0.001 was observed. The wider prolapsectomy achievable with CPH34 HV determined an overall 3.7% relapse rate in patients with high prevalence of large internal rectal prolapse, coupled with high satisfaction index, significant reduction of CSS, and very low complication rates.

  13. Inventory of Federal Energy-Related Environment and Safety Research for FY 1978. Volume III, interactive terminal users guide

    Energy Technology Data Exchange (ETDEWEB)

    Miller, C. E.; Barker, Janice F.

    1979-12-01

    This users' guide was prepared to provide interested persons access to, via computer terminals, federally funded energy-related environmental and safety research projects for FY 1978. Although this information is also available in hardbound volumes, this on-line searching capability is expected to reduce the time required to answer ad hoc questions and, at the same time, produce meaningful reports. The data contained in this data base are not exhaustive and represent research reported by the following agencies: Department of Agriculture, Department of Commerce, Department of Defense, Department of Energy, Department of Health, Education, and Welfare, Department of the Interior, Department of Transportation, Federal Energy Administration, National Aeronautics and Space Administration, National Science Foundation, Nuclear Regulatory Commission, Tennessee Valley Authority, U.S. Coast Guard, and the U.S. Environmental Protection Agency.

  14. Artificial heart development program. Volume II. System support. Phase III summary report, July 1, 1973--September 30, 1977

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    Volume 2 covers major activities of the Artificial Heart Development program that supported the design, fabrication, and test of the system demonstration units. Section A.1.0 provides a listing beyond that of the body of the report on the components needed for an implantation. It also presents glove box sterilization calibration results and results of an extensive mock circulation calibration. Section A.2.0 provides detailed procedures for assembly, preparing for use, and the use of the system and major components. Section A.3.0 covers the component research and development activities undertaken to improve components of the existing system units and to prepare for a future prototype system. Section A.4.0 provides a listing of the top assembly drawings of the major systems variations fabricated and tested.

  15. Pressure-volume-temperature and excess molar volume prediction of amorphous and crystallizable polymer blends by equation of state

    Institute of Scientific and Technical Information of China (English)

    Fakhri Yousefi; Hajir Karimi; Maryam Gomar

    2015-01-01

    In this work the statistical mechanical equation of state was developed for volumetric properties of crystal ine and amorphous polymer blends. The Ihm–Song–Mason equations of state (ISMEOS) based on temperature and density at melting point (Tm andρm) as scaling constants were developed for crystalline polymers such as poly(propylene glycol)+poly(ethylene glycol)-200 (PPG+PEG-200), poly(ethylene glycol) methyl ether-300 (PEGME-350)+PEG-200 and PEGME-350+PEG-600. Furthermore, for amorphous polymer blends con-taining poly(2,6-dimethyl-1,4-phenylene oxide) (PPO)+polystyrene (PS) and PS+poly(vinylmethylether) (PVME), the density and surface tension at glass transition (ρg andγg) were used for estimation of second Virial coefficient. The calculation of second Virial coefficients (B2), effective van der Waals co-volume (b) and correction factor (α) was required for judgment about applicability of this model. The obtained results by ISMEOS for crys-talline and amorphous polymer blends were in good agreement with the experimental data with absolute aver-age deviations of 0.84%and 1.04%, respectively.

  16. Left Atrial Volume Index and Prediction of Events in Acute Coronary Syndrome: Solar Registry

    Directory of Open Access Journals (Sweden)

    Jose Alves Secundo Junior

    2014-10-01

    Full Text Available Background: According to some international studies, patients with acute coronary syndrome (ACS and increased left atrial volume index (LAVI have worse long-term prognosis. However, national Brazilian studies confirming this prediction are still lacking. Objective: To evaluate LAVI as a predictor of major cardiovascular events (MCE in patients with ACS during a 365-day follow-up. Methods: Prospective cohort of 171 patients diagnosed with ACS whose LAVI was calculated within 48 hours after hospital admission. According to LAVI, two groups were categorized: normal LAVI (≤ 32 mL/m2 and increased LAVI (> 32 mL/m2. Both groups were compared regarding clinical and echocardiographic characteristics, in- and out-of-hospital outcomes, and occurrence of ECM in up to 365 days. Results: Increased LAVI was observed in 78 patients (45%, and was associated with older age, higher body mass index, hypertension, history of myocardial infarction and previous angioplasty, and lower creatinine clearance and ejection fraction. During hospitalization, acute pulmonary edema was more frequent in patients with increased LAVI (14.1% vs. 4.3%, p = 0.024. After discharge, the occurrence of combined outcome for MCE was higher (p = 0.001 in the group with increased LAVI (26% as compared to the normal LAVI group (7% [RR (95% CI = 3.46 (1.54-7.73 vs. 0.80 (0.69-0.92]. After Cox regression, increased LAVI increased the probability of MCE (HR = 3.08, 95% CI = 1.28-7.40, p = 0.012. Conclusion: Increased LAVI is an important predictor of MCE in a one-year follow-up.

  17. Comparison of Puff Volume With Cigarettes per Day in Predicting Nicotine Uptake Among Daily Smokers.

    Science.gov (United States)

    Krebs, Nicolle M; Chen, Allshine; Zhu, Junjia; Sun, Dongxiao; Liao, Jason; Stennett, Andrea L; Muscat, Joshua E

    2016-07-01

    The role of inhalation behaviors as predictors of nicotine uptake was examined in the Pennsylvania Adult Smoking Study (2012-2014), a study of 332 adults whose cigarette smoking was measured in a naturalistic environment (e.g., at home) with portable handheld topography devices. Piecewise regression analyses showed that levels of salivary cotinine, trans-3'-hydroxycotinine, and total salivary nicotine metabolites (cotinine + trans-3'-hydroxycotinine) increased linearly up to a level of about 1 pack per day (20 cigarettes per day (CPD)) (P < 0.01). Total daily puff volume (TDPV; in mL) (P < 0.05) and total daily number of puffs (P < 0.05), but not other topographical measures, increased linearly with CPD up to a level of about 1 pack per day. The mean level of cotinine per cigarette did not change above 20 CPD and was 36% lower in heavy smokers (≥20 CPD) than in lighter smokers (<20 CPD) (15.6 ng/mL vs. 24.5 ng/mL, respectively; P < 0.01). Mediation models showed that TDPV accounted for 43%-63% of the association between CPD and nicotine metabolites for smokers of <20 CPD. TDPV was the best predictor of nicotine metabolite levels in light-to-moderate smokers (1-19 CPD). In contrast, neither CPD, total daily number of puffs, nor TDPV predicted nicotine metabolite levels above 20 CPD (up to 40 CPD). Finally, although light smokers are traditionally considered less dependent on nicotine, these findings suggest that they are exposed to more nicotine per cigarette than are heavy smokers due to more frequent, intensive puffing.

  18. Lateral Ventricle Volume Asymmetry Predicts Midline Shift in Severe Traumatic Brain Injury

    Science.gov (United States)

    Schmalfuss, Ilona; Heaton, Shelley C.; Gabrielli, Andrea; Hannay, H. Julia; Papa, Linda; Brophy, Gretchen M.; Wang, Kevin K.W.; Büki, András; Schwarcz, Attila; Hayes, Ronald L.; Robertson, Claudia S.; Robicsek, Steven A.

    2015-01-01

    Abstract Midline shift following severe traumatic brain injury (sTBI) detected on computed tomography (CT) scans is an established predictor of poor outcome. We hypothesized that lateral ventricular volume (LVV) asymmetry is an earlier sign of developing asymmetric intracranial pathology than midline shift. This retrospective analysis was performed on data from 84 adults with blunt sTBI requiring a ventriculostomy who presented to a Level I trauma center. Seventy-six patients underwent serial CTs within 3 h and an average of three scans within the first 10 d of sTBI. Left and right LVVs were quantified by computer-assisted manual volumetric measurements. LVV ratios (LVR) were determined on the admission CT to evaluate ventricular asymmetry. The relationship between the admission LVR value and subsequent midline shift development was tested using receiver operating characteristic (ROC) analysis, and odds ratio (OR) and relative risk tests. Sixty patients had no >5 mm midline shift on the initial admission scan. Of these, 15 patients developed it subsequently (16 patients already had >5 mm midline shift on admission scans). For >5 mm midline shift development, admission LVR of >1.67 was shown to have a sensitivity of 73.3% and a specificity of 73.3% (area under the curve=0.782; p1.67 as exposure yielded an OR of 7.56 (p<0.01), and a risk ratio of 4.42 (p<0.01) for midline shift development as unfavorable outcome. We propose that LVR captures LVV asymmetry and is not only related to, but also predicts the development of midline shift already at admission CT examination. Lateral ventricles may have a higher “compliance” than midline structures to developing asymmetric brain pathology. LVR analysis is simple, rapidly accomplished and may allow earlier interventions to attenuate midline shift and potentially improve ultimate outcomes. PMID:25752227

  19. Left Atrial Volume Index and Prediction of Events in Acute Coronary Syndrome: Solar Registry

    Science.gov (United States)

    Secundo Junior, Jose Alves; Santos, Marcos Antonio Almeida; Faro, Gustavo Baptista de Almeida; Soares, Camile Bittencourt; Silva, Allyson Matos Porto; Secundo, Paulo Fernando Carvalho; Teixeira, Clarissa Karine Cardoso; Oliveira, Joselina Luzia Menezes; Barreto Filho, Jose Augusto Soares; Sousa, Antônio Carlos Sobral

    2014-01-01

    Background According to some international studies, patients with acute coronary syndrome (ACS) and increased left atrial volume index (LAVI) have worse long-term prognosis. However, national Brazilian studies confirming this prediction are still lacking. Objective To evaluate LAVI as a predictor of major cardiovascular events (MCE) in patients with ACS during a 365-day follow-up. Methods Prospective cohort of 171 patients diagnosed with ACS whose LAVI was calculated within 48 hours after hospital admission. According to LAVI, two groups were categorized: normal LAVI (≤ 32 mL/m2) and increased LAVI (> 32 mL/m2). Both groups were compared regarding clinical and echocardiographic characteristics, in- and out-of-hospital outcomes, and occurrence of ECM in up to 365 days. Results Increased LAVI was observed in 78 patients (45%), and was associated with older age, higher body mass index, hypertension, history of myocardial infarction and previous angioplasty, and lower creatinine clearance and ejection fraction. During hospitalization, acute pulmonary edema was more frequent in patients with increased LAVI (14.1% vs. 4.3%, p = 0.024). After discharge, the occurrence of combined outcome for MCE was higher (p = 0.001) in the group with increased LAVI (26%) as compared to the normal LAVI group (7%) [RR (95% CI) = 3.46 (1.54-7.73) vs. 0.80 (0.69-0.92)]. After Cox regression, increased LAVI increased the probability of MCE (HR = 3.08, 95% CI = 1.28-7.40, p = 0.012). Conclusion Increased LAVI is an important predictor of MCE in a one-year follow-up. PMID:25119895

  20. Lateral Ventricle Volume Asymmetry Predicts Midline Shift in Severe Traumatic Brain Injury.

    Science.gov (United States)

    Tóth, Arnold; Schmalfuss, Ilona; Heaton, Shelley C; Gabrielli, Andrea; Hannay, H Julia; Papa, Linda; Brophy, Gretchen M; Wang, Kevin K W; Büki, András; Schwarcz, Attila; Hayes, Ronald L; Robertson, Claudia S; Robicsek, Steven A

    2015-09-01

    Midline shift following severe traumatic brain injury (sTBI) detected on computed tomography (CT) scans is an established predictor of poor outcome. We hypothesized that lateral ventricular volume (LVV) asymmetry is an earlier sign of developing asymmetric intracranial pathology than midline shift. This retrospective analysis was performed on data from 84 adults with blunt sTBI requiring a ventriculostomy who presented to a Level I trauma center. Seventy-six patients underwent serial CTs within 3 h and an average of three scans within the first 10 d of sTBI. Left and right LVVs were quantified by computer-assisted manual volumetric measurements. LVV ratios (LVR) were determined on the admission CT to evaluate ventricular asymmetry. The relationship between the admission LVR value and subsequent midline shift development was tested using receiver operating characteristic (ROC) analysis, and odds ratio (OR) and relative risk tests. Sixty patients had no >5 mm midline shift on the initial admission scan. Of these, 15 patients developed it subsequently (16 patients already had >5 mm midline shift on admission scans). For >5 mm midline shift development, admission LVR of >1.67 was shown to have a sensitivity of 73.3% and a specificity of 73.3% (area under the curve=0.782; p1.67 as exposure yielded an OR of 7.56 (pasymmetry and is not only related to, but also predicts the development of midline shift already at admission CT examination. Lateral ventricles may have a higher "compliance" than midline structures to developing asymmetric brain pathology. LVR analysis is simple, rapidly accomplished and may allow earlier interventions to attenuate midline shift and potentially improve ultimate outcomes.

  1. Very low cerebral blood volume predicts parenchymal hematoma in acute ischemic stroke

    DEFF Research Database (Denmark)

    Hermitte, Laure; Cho, Tae-Hee; Ozenne, Brice;

    2013-01-01

    BACKGROUND AND PURPOSE: Parenchymal hematoma (PH) may worsen the outcome of patients with stroke. The aim of our study was to confirm the relationship between the volume of very low cerebral blood volume (CBV) and PH using a European multicenter database (I-KNOW). A secondary objective was to exp...

  2. Does delivery volume of family physicians predict maternal and newborn outcome?

    Energy Technology Data Exchange (ETDEWEB)

    Klein, M.C. [Children' s and Women' s Health Centre, Dept. of Family Practice, Vancouver, British Columbia (Canada); Univ. of British Columbia, Dept. of Family Practice, Vancouver, British Columbia (Canada); Spence, A. [Children' s and Women' s Health Centre, Dept. of Family Practice, Vancouver, British Columbia (Canada); Kaczorowski, J. [McMaster Univ., Depts. of Family Medicine and of Clinical Epidemiology and Biostatistics, Hamilton, Ontario (Canada); Kelly, A. [Children' s and Women' s Health Centre, Dept. of Family Practice, Vancouver, British Columbia (Canada); Univ. of British Columbia, Dept. of Health Care and Epidemiology, Vancouver, British Columbia (Canada); Grzybowski, S. [Univ. of British Columbia, Dept. of Family Practice, Vancouver, British Columbia (Canada)

    2002-05-01

    The number of births attended by individual family physicians who practice intrapartum care varies. We wanted to determine if the practice-volume relations that have been shown in other fields of medical practice also exist in maternity care practice by family doctors. For the period April 1997 to August 1998, we analyzed all singleton births at a major maternity teaching hospital for which the family physician was the responsible physician. Physicians were grouped into 3 categories on the basis of the number of births they attended each year: fewer than 12, 12 to 24, and 25 or more. Physicians with a low volume of deliveries (72 physicians, 549 births), those with a medium volume of deliveries (34 physicians, 871 births) and those with a high volume of deliveries (46 physicians, 3024 births) were compared in terms of maternal and newborn outcomes. The main outcome measures were maternal morbidity, 5-minute Apgar score and admission of the baby to the neonatal intensive care unit or special care unit. Secondary outcomes were obstetric procedures and consultation patterns. There was no difference among the 3 volume cohorts in terms of rates of maternal complications of delivery, 5-minute Apgar scores of less than 7 or admissions to the neonatal intensive care unit or the special care unit, either before or after adjustment for parity, pregnancy-induced hypertension, diabetes, ethnicity, lone parent status, maternal age, gestational age, newborn birth weight and newborn head circumference at birth. High-and medium-volume family physicians consulted with obstetricians less often than low-volume family physicians (adjusted odds ratio [OR] 0.586 [95% confidence interval, CI, 0.479-0.718] and 0.739 [95% Cl 0.583-0.935] respectively). High-and medium-volume family physicians transferred the delivery to an obstetrician less often than low-volume family physicians (adjusted OR 0.668 [95% CI 0.542-0.823] and 0.776 [95% Cl 0.607-0.992] respectively). Inductions were performed

  3. Imprinting Hatchery Reared Salmon and Steelhead Trout for Homing, Volume II of III; Data Summaries, 1978-1983 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Slatick, Emil; Ringe, R.R.; Zaugg, Waldo S. (Northwest and Alaska Fisheries Science Center, Coastal Zone and Estuarine Studies Division, Seattle, WA)

    1988-02-02

    The main functions of the National Marine Fisheries Service (NMFS) aquaculture task biologists and contractual scientists involved in the 1978 homing studies were primarily a surveillance of fish physiology, disease, and relative survival during culture in marine net-pens, to determine if there were any unusual factors that might affect imprinting and homing behavior. The studies were conducted with little background knowledge of the implications of disease and physiology on imprinting and homing in salmonids. The health status or the stocks were quite variable as could be expected. The Dworshak and Wells Hatcheries steelhead suffered from some early stresses in seawater, probably osmoregulatory. The incidences of latent BKD in the Wells and Chelan Hatcheries steelhead and Kooskia Hatchery spring chinook salmon were extremely high, and how these will affect survival in the ocean is not known. Gill enzyme activity in the Dworshak and Chelan Hatcheries steelhead at release was low. Of the steelhead, survival in the Tucannon Hatchery stock will probably be the highest, with Dworshak Hatchery stock the lowest. This report contains the data for the narratives in Volume I.

  4. ELUCID - Exploring the Local Universe with reConstructed Initial Density field III: Constrained Simulation in the SDSS Volume

    CERN Document Server

    Wang, Huiyuan; Yang, Xiaohu; Zhang, Youcai; Shi, JingJing; Jing, Y P; Liu, Chengze; Li, Shijie; Kang, Xi; Gao, Yang

    2016-01-01

    A method we developed recently for the reconstruction of the initial density field in the nearby Universe is applied to the Sloan Digital Sky Survey Data Release 7. A high-resolution N-body constrained simulation (CS) of the reconstructed initial condition, with $3072^3$ particles evolved in a 500 Mpc/h box, is carried out and analyzed in terms of the statistical properties of the final density field and its relation with the distribution of SDSS galaxies. We find that the statistical properties of the cosmic web and the halo populations are accurately reproduced in the CS. The galaxy density field is strongly correlated with the CS density field, with a bias that depend on both galaxy luminosity and color. Our further investigations show that the CS provides robust quantities describing the environments within which the observed galaxies and galaxy systems reside. Cosmic variance is greatly reduced in the CS so that the statistical uncertainties can be controlled effectively even for samples of small volumes...

  5. Prediction of free-volume-type correlations in glassy chalcogenides from positron annihilation lifetime measurements

    Energy Technology Data Exchange (ETDEWEB)

    Shpotyuk, O., E-mail: shpotyuk@novas.lviv.ua [Institute of Materials of SRC “Carat”, 212 Stryjska Str., Lviv 79031 (Ukraine); Institute of Physics of Jan Dlugosz University, 13/15 al. Armii Krajowej, Czestcochowa 42200 (Poland); Ingram, A. [Opole University of Technology, 75 Ozimska Str., Opole 45370 (Poland); Shpotyuk, M. [Institute of Materials of SRC “Carat”, 212 Stryjska Str., Lviv 79031 (Ukraine); Lviv Polytechnic National University, 12 Bandery Str., Lviv 79013 (Ukraine); Filipecki, J. [Institute of Physics of Jan Dlugosz University, 13/15 al. Armii Krajowej, Czestcochowa 42200 (Poland)

    2014-11-01

    Highlights: • Decisive role of specific chemical environment in free-volume correlations in glass. • Realistic free volumes in As–S/Se glass are defined by newly modified τ{sub 2}-R formula. • Overestimated void sizes in chalcogenide glass as compared with molecular polymers. - Abstract: A newly modified correlation equation between defect-related positron lifetime determined within two-state trapping model and radius of corresponding free-volume-type defects was proposed to describe compositional variations in atomic-deficient structure of covalent-bonded chalcogenides like binary As–S/Se glasses. Specific chemical environment of free-volume voids around neighboring network-forming polyhedrons was shown to play a decisive role in this correlation, leading to systematically enhanced volumes in comparison with typical molecular substrates, such as polymers.

  6. Application analysis of solar total energy systems to the residential sector. Volume III, conceptual design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-07-01

    The objective of the work described in this volume was to conceptualize suitable designs for solar total energy systems for the following residential market segments: single-family detached homes, single-family attached units (townhouses), low-rise apartments, and high-rise apartments. Conceptual designs for the total energy systems are based on parabolic trough collectors in conjunction with a 100 kWe organic Rankine cycle heat engine or a flat-plate, water-cooled photovoltaic array. The ORC-based systems are designed to operate as either independent (stand alone) systems that burn fossil fuel for backup electricity or as systems that purchase electricity from a utility grid for electrical backup. The ORC designs are classified as (1) a high temperature system designed to operate at 600/sup 0/F and (2) a low temperature system designed to operate at 300/sup 0/F. The 600/sup 0/F ORC system that purchases grid electricity as backup utilizes the thermal tracking principle and the 300/sup 0/F ORC system tracks the combined thermal and electrical loads. Reject heat from the condenser supplies thermal energy for heating and cooling. All of the ORC systems utilize fossil fuel boilers to supply backup thermal energy to both the primary (electrical generating) cycle and the secondary (thermal) cycle. Space heating is supplied by a central hot water (hydronic) system and a central absorption chiller supplies the space cooling loads. A central hot water system supplies domestic hot water. The photovoltaic system uses a central electrical vapor compression air conditioning system for space cooling, with space heating and domestic hot water provided by reject heat from the water-cooled array. All of the systems incorporate low temperature thermal storage (based on water as the storage medium) and lead--acid battery storage for electricity; in addition, the 600/sup 0/F ORC system uses a therminol-rock high temperature storage for the primary cycle. (WHK)

  7. Stroke volume variation and pleth variability index to predict fluid responsiveness during resection of primary retroperitoneal tumors in Hans Chinese.

    Science.gov (United States)

    Fu, Q; Mi, W D; Zhang, H

    2012-02-01

    Respiration variation in arterial pulse pressure (ΔPP) and pulse oximetry plethysmographic waveform amplitude (ΔPOP) are accurate predictors of fluid responsiveness in mechanically ventilated patients. We hypothesized that stroke volume variation (SVV) and pleth variability index (PVI) can predict fluid responsiveness in mechanically ventilated patients during major surgical procedures in Hans Chinese. This prospective study consisted of fifty-five Hans Chinese patients undergoing resection of primary retroperitoneal tumors (PRPT). During the surgical procedures, hemodynamic data [central venous pressure (CVP), cardiac index (CI), stroke volume index (SVI), SVV, and PVI] were recorded before and after volume expansion (VE) (8 ml•kg-1 of 6% hydroxyethyl starch 130/0.4). Fluid responsiveness was defined as an increase in SVI ≥ 10% after VE. Four patients were excluded from analysis for arrhythmia or obvious hemorrhage during VE. Baseline SVV correlated well with baseline PVI and the changes in SVV was correlated with the changes in PVI (p Chinese.

  8. Adoption of community-based cardiac rehabilitation programs and physical activity following phase III cardiac rehabilitation in Scotland: a prospective and predictive study.

    Science.gov (United States)

    Sniehotta, Falko F; Gorski, Charlotta; Araujo-Soares, Vera

    2010-09-01

    Little is known about levels of physical activity and attendance at phase IV community-based Cardiac Rehabilitation (CR) programs following completion of exercise-focussed, hospital-based phase III CR. This study aims to test, compare and combine the predictive utility of the Common-Sense Self-Regulation Model (CS-SRM) and the extended Theory of Planned Behaviour (TPB) with action planning for two rehabilitation behaviours: physical activity and phase IV CR attendance. Individuals diagnosed with coronary heart disease (n = 103) completed baseline measures of illness perceptions, intentions, perceived behavioural control (PBC), action planning and past physical activity in the last week of a phase III CR program, and 95 participants completed follow-up measures of physical activity and attended phase IV CR (objectively confirmed) 2 months later. Only one predictor (PBC/cyclical timeline) significantly predicted levels and change of physical activity. While illness perceptions were not predictive of phase IV CR attendance, the extended TPB model showed good predictive power with action planning and intention as the most powerful predictors. Amongst participants who planned when and where to attend phase IV CR at the end of phase III rehabilitation, 65.9% subsequently attended a phase IV CR program compared to only 18.5% of those who had not made a plan. This study adds to our understanding of cardiac rehabilitation behaviour after completion of health service delivered programs. Comparing theoretical models and rehabilitation behaviours contributes to the development of behaviour theory.

  9. Predicted versus measured thoracic gas volumes of collegiate athletes made by the BOD POD air displacement plethysmography system.

    Science.gov (United States)

    Wagner, Dale R

    2015-10-01

    Measured (TGVm) and predicted (TGVp) thoracic gas volumes from the BOD POD were compared in 33 lean, university athletes. On average, TGVp (3.529 L) was not significantly different (p = 0.343) from TGVm (3.628 L); however, there was a bias (r = -0.703, p < 0.001). The difference in the percentage of body fat (BF) was within ±2% BF for 76% of the sample, but athletes at the extremes of height should have TGV measured.

  10. A comparison of Child-Pugh, APACHE II and APACHE III scoring systems in predicting hospital mortality of patients with liver cirrhosis

    Directory of Open Access Journals (Sweden)

    Romanos John

    2003-05-01

    Full Text Available Abstract Background The aim of this study was to assess the prognostic accuracy of Child-Pugh and APACHE II and III scoring systems in predicting short-term, hospital mortality of patients with liver cirrhosis. Methods 200 admissions of 147 cirrhotic patients (44% viral-associated liver cirrhosis, 33% alcoholic, 18.5% cryptogenic, 4.5% both viral and alcoholic were studied prospectively. Clinical and laboratory data conforming to the Child-Pugh, APACHE II and III scores were recorded on day 1 for all patients. Discrimination was evaluated using receiver operating characteristic (ROC curves and area under a ROC curve (AUC. Calibration was estimated using the Hosmer-Lemeshow goodness-of-fit test. Results Overall mortality was 11.5%. The mean Child-Pugh, APACHE II and III scores for survivors were found to be significantly lower than those of nonsurvivors. Discrimination was excellent for Child-Pugh (ROC AUC: 0.859 and APACHE III (ROC AUC: 0.816 scores, and acceptable for APACHE II score (ROC AUC: 0.759. Although the Hosmer-Lemeshow statistic revealed adequate goodness-of-fit for Child-Pugh score (P = 0.192, this was not the case for APACHE II and III scores (P = 0.004 and 0.003 respectively Conclusion Our results indicate that, of the three models, Child-Pugh score had the least statistically significant discrepancy between predicted and observed mortality across the strata of increasing predicting mortality. This supports the hypothesis that APACHE scores do not work accurately outside ICU settings.

  11. Commercial-sector energy-consumption data-base-development project. Volume III. Analysis of energy consumption in office buildings

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-04-01

    Results are presented of an effort to develop comprehensive and reliable energy consumption data for office buildings. A survey was conducted of readily available energy consumption data and the literature that describes the factors which drive energy use in such buildings was analyzed. Information on heating, ventilating, and air conditioning (HVAC) systems was assembled. A number of building energy use simulation programs were reviewed to determine their suitability for estimating energy consumption by function and the effects of tradeoffs in building design and operating parameters on building energy use. Simulations using the AXCESS program were conducted. The 1975 data base of the Building Owners and Managers Association (BOMA) was obtained and analyzed. Data describing energy use on a regional and national basis were developed, and regression equations based on these were obtained. The ability of these equations to predict average energy use was then confirmed by applying them to four office buildings not in the BOMA data base. A number of proposals for the further improvement of the equations were developed, including additional data collection. Specifically, the survey of actual and simulated data on a regional basis is reported in Section 2. HVAC systems are discussed in Sections 3 and 4. BOMA obtains annual data on about 1000 buildings covering such items as location, floor area, height, age, average occupancy rate, average number of employees, types of tenants, type of air conditioning, and energy consumption by fuel and the description and analyses of the BOMA data are presented in Sections 5 and 6.

  12. Impact of tumour volume on prediction of progression-free survival in sinonasal cancer

    Directory of Open Access Journals (Sweden)

    Hennersdorf Florian

    2015-09-01

    Full Text Available Background. The present study aimed to analyse potential prognostic factors, with emphasis on tumour volume, in determining progression free survival (PFS for malignancies of the nasal cavity and the paranasal sinuses.

  13. PREDICTION OF CARBON CONCENTRATION AND FERRITE VOLUME FRACTION OF HOT-ROLLED STEEL STRIP DURING LAMINAR COOLING

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A phase transformation model was presented for predicting the phase fraction transformed and the carbon concentration in austenite for austenite to ferrite transformation during laminar cooling on run-out table in hot rolling strip mill. In this model, the parameter k in Avrami equation was developed for carbon steels. The wide range of chemical composition, the primary austenite grain size, and the retained strain were taken into account. It can be used to predict the ferrite volume fraction and the carbon concentration in austenite of hot-rolled steel strip during laminar cooling on run-out table. The coiling temperature controlling model was also presented to calculate the temperature of steel strip. The transformation kinetics of austenite to ferrite and the evolution of carbon concentration in austenite at different temperatures during cooling were investigated in the hot rolled Q235B strip for thickness of 9.35, 6.4, and 3.2mm. The ferrite volume fraction along the length of the strip was also calculated. The calculated ferrite volume fraction was compared with the log data from hot strip mill and the calculated results were in agreement with the experimental ones. The present study is a part of the prediction of the mechanical properties of hot-rolled steel strip, and it has already been used on-line and off-line in the hot strip mill.

  14. LIQUID PHASE FISCHER-TROPSCH (III & IV) DEMONSTRATION IN THE LAPORTE ALTERNATIVE FUELS DEVELOPMENT UNIT. Final Topical Report. Volume I/II: Main Report. Task 1: Engineering Modifications (Fischer-Tropsch III & IV Demonstration) and Task 2: AFDU Shakedown, Operations, Deactivation (Shut-Down) and Disposal (Fischer-Tropsch III & IV Demonstration).

    Energy Technology Data Exchange (ETDEWEB)

    Bharat L. Bhatt

    1999-06-01

    Slurry phase Fischer-Tropsch technology was successfully demonstrated in DOE's Alternative Fuels Development Unit (AFDU) at LaPorte, Texas. Earlier work at LaPorte, with iron catalysts in 1992 and 1994, had established proof-of-concept status for the slurry phase process. The third campaign (Fischer-Tropsch III), in 1996, aimed at aggressively extending the operability of the slurry reactor using a proprietary cobalt catalyst. Due to an irreversible plugging of catalyst-wax separation filters as a result of unexpected catalyst fines generation, the operations had to be terminated after seven days on-stream. Following an extensive post-run investigation by the participants, the campaign was successfully completed in March-April 1998, with an improved proprietary cobalt catalyst. These runs were sponsored by the U. S. Department of Energy (DOE), Air Products & Chemicals, Inc., and Shell Synthetic Fuels, Inc. (SSFI). A productivity of approximately 140 grams (gm) of hydrocarbons (HC)/ hour (hr)-liter (lit) of expanded slurry volume was achieved at reasonable system stability during the second trial (Fischer-Tropsch IV). The productivity ranged from 110-140 at various conditions during the 18 days of operations. The catalyst/wax filters performed well throughout the demonstration, producing a clean wax product. For the most part, only one of the four filter housings was needed for catalyst/wax filtration. The filter flux appeared to exceed the design flux. A combination of use of a stronger catalyst and some innovative filtration techniques were responsible for this success. There was no sign of catalyst particle attrition and very little erosion of the slurry pump was observed, in contrast to the Fischer-Tropsch III operations. The reactor operated hydrodynamically stable with uniform temperature profile and gas hold-ups. Nuclear density and differential pressure measurements indicated somewhat higher than expected gas hold-up (45 - 50 vol%) during Fischer

  15. Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease.

    Science.gov (United States)

    von Rhein, Michael; Buchmann, Andreas; Hagmann, Cornelia; Huber, Reto; Klaver, Peter; Knirsch, Walter; Latal, Beatrice

    2014-01-01

    Patients with complex congenital heart disease are at risk for neurodevelopmental impairments. Evidence suggests that brain maturation can be delayed and pre- and postoperative brain injury may occur, and there is limited information on the long-term effect of congenital heart disease on brain development and function in adolescent patients. At a mean age of 13.8 years, 39 adolescent survivors of childhood cardiopulmonary bypass surgery with no structural brain lesions evident through conventional cerebral magnetic resonance imaging and 32 healthy control subjects underwent extensive neurodevelopmental assessment and cerebral magnetic resonance imaging. Cerebral scans were analysed quantitatively using surface-based and voxel-based morphometry. Compared with control subjects, patients had lower total brain (P = 0.003), white matter (P = 0.004) and cortical grey matter (P = 0.005) volumes, whereas cerebrospinal fluid volumes were not different. Regional brain volume reduction ranged from 5.3% (cortical grey matter) to 11% (corpus callosum). Adolescents with cyanotic heart disease showed more brain volume loss than those with acyanotic heart disease, particularly in the white matter, thalami, hippocampi and corpus callosum (all P-values Brain volume reduction correlated significantly with cognitive, motor and executive functions (grey matter: P < 0.05, white matter: P < 0.01). Our findings suggest that there are long-lasting cerebral changes in adolescent survivors of cardiopulmonary bypass surgery for congenital heart disease and that these changes are associated with functional outcome.

  16. Accuracy evaluation of Fourier series analysis and singular spectrum analysis for predicting the volume of motorcycle sales in Indonesia

    Science.gov (United States)

    Sasmita, Yoga; Darmawan, Gumgum

    2017-08-01

    This research aims to evaluate the performance of forecasting by Fourier Series Analysis (FSA) and Singular Spectrum Analysis (SSA) which are more explorative and not requiring parametric assumption. Those methods are applied to predicting the volume of motorcycle sales in Indonesia from January 2005 to December 2016 (monthly). Both models are suitable for seasonal and trend component data. Technically, FSA defines time domain as the result of trend and seasonal component in different frequencies which is difficult to identify in the time domain analysis. With the hidden period is 2,918 ≈ 3 and significant model order is 3, FSA model is used to predict testing data. Meanwhile, SSA has two main processes, decomposition and reconstruction. SSA decomposes the time series data into different components. The reconstruction process starts with grouping the decomposition result based on similarity period of each component in trajectory matrix. With the optimum of window length (L = 53) and grouping effect (r = 4), SSA predicting testing data. Forecasting accuracy evaluation is done based on Mean Absolute Percentage Error (MAPE), Mean Absolute Error (MAE) and Root Mean Square Error (RMSE). The result shows that in the next 12 month, SSA has MAPE = 13.54 percent, MAE = 61,168.43 and RMSE = 75,244.92 and FSA has MAPE = 28.19 percent, MAE = 119,718.43 and RMSE = 142,511.17. Therefore, to predict volume of motorcycle sales in the next period should use SSA method which has better performance based on its accuracy.

  17. Volume of blood suctioned during vacuum-assisted breast biopsy predicts later hematoma formation

    Directory of Open Access Journals (Sweden)

    Panopoulou Effrosyni

    2010-03-01

    Full Text Available Abstract Background To evaluate whether the volume of blood suctioned during vacuum-assisted breast biopsy (VABB is associated with hematoma formation and progression, patient's age and histology of the lesion. Findings 177 women underwent VABB according to standardized protocol. The volume of blood suctioned and hematoma formation were noted at the end of the procedure, as did the subsequent development and progression of hematoma. First- and second-order logistic regression was performed, where appropriate. Cases with hematoma presented with greater volume of blood suctioned (63.8 ± 44.7 cc vs. 17.2 ± 32.9 cc; p Conclusion The likelihood of hematoma is increasing along with increasing amount of blood suctioned, reaching a plateau approximately at 80 cc of blood lost.

  18. Predicting Nonauditory Adverse Radiation Effects Following Radiosurgery for Vestibular Schwannoma: A Volume and Dosimetric Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hayhurst, Caroline; Monsalves, Eric; Bernstein, Mark; Gentili, Fred [Gamma Knife Unit, Division of Neurosurgery, University Health Network, Toronto (Canada); Heydarian, Mostafa; Tsao, May [Radiation Medicine Program, Princess Margaret Hospital, Toronto (Canada); Schwartz, Michael [Radiation Oncology Program and Division of Neurosurgery, Sunnybrook Hospital, Toronto (Canada); Prooijen, Monique van [Radiation Medicine Program, Princess Margaret Hospital, Toronto (Canada); Millar, Barbara-Ann; Menard, Cynthia [Radiation Oncology Program, Princess Margaret Hospital, Toronto (Canada); Kulkarni, Abhaya V. [Division of Neurosurgery, Hospital for Sick Children, University of Toronto (Canada); Laperriere, Norm [Radiation Oncology Program, Princess Margaret Hospital, Toronto (Canada); Zadeh, Gelareh, E-mail: Gelareh.Zadeh@uhn.on.ca [Gamma Knife Unit, Division of Neurosurgery, University Health Network, Toronto (Canada)

    2012-04-01

    Purpose: To define clinical and dosimetric predictors of nonauditory adverse radiation effects after radiosurgery for vestibular schwannoma treated with a 12 Gy prescription dose. Methods: We retrospectively reviewed our experience of vestibular schwannoma patients treated between September 2005 and December 2009. Two hundred patients were treated at a 12 Gy prescription dose; 80 had complete clinical and radiological follow-up for at least 24 months (median, 28.5 months). All treatment plans were reviewed for target volume and dosimetry characteristics; gradient index; homogeneity index, defined as the maximum dose in the treatment volume divided by the prescription dose; conformity index; brainstem; and trigeminal nerve dose. All adverse radiation effects (ARE) were recorded. Because the intent of our study was to focus on the nonauditory adverse effects, hearing outcome was not evaluated in this study. Results: Twenty-seven (33.8%) patients developed ARE, 5 (6%) developed hydrocephalus, 10 (12.5%) reported new ataxia, 17 (21%) developed trigeminal dysfunction, 3 (3.75%) had facial weakness, and 1 patient developed hemifacial spasm. The development of edema within the pons was significantly associated with ARE (p = 0.001). On multivariate analysis, only target volume is a significant predictor of ARE (p = 0.001). There is a target volume threshold of 5 cm3, above which ARE are more likely. The treatment plan dosimetric characteristics are not associated with ARE, although the maximum dose to the 5th nerve is a significant predictor of trigeminal dysfunction, with a threshold of 9 Gy. The overall 2-year tumor control rate was 96%. Conclusions: Target volume is the most important predictor of adverse radiation effects, and we identified the significant treatment volume threshold to be 5 cm3. We also established through our series that the maximum tolerable dose to the 5th nerve is 9 Gy.

  19. Neoadjuvant Doxorubicin/Cyclophosphamide Followed by Ixabepilone or Paclitaxel in Early Stage Breast Cancer and Evaluation of βIII-Tubulin Expression as a Predictive Marker

    Science.gov (United States)

    Tseng, Ling-Ming; Chan, Stephen; Chacko, Raju T.; Campone, Mario; Manikhas, Alexy; Nag, Shona M.; Leichman, Cynthia G.; Dasappa, Lokanatha; Fasching, Peter A.; Hurtado de Mendoza, Fernando; Symmans, W. Fraser; Liu, David; Mukhopadhyay, Pralay; Horak, Christine; Xing, Guan; Pusztai, Lajos

    2013-01-01

    Background. This randomized phase II trial was designed to compare the rate of pathologic complete response (pCR) induced by neoadjuvant cyclophosphamide plus doxorubicin (AC) followed by ixabepilone or paclitaxel in women with early stage breast cancer (BC). Expression of βIII-tubulin as a predictive marker was also evaluated. Patients and Methods. Women with untreated, histologically confirmed primary invasive breast adenocarcinoma received four cycles of AC followed by 1:1 randomization to either ixabepilone 40 mg/m2 (3-hour infusion) every 3 weeks for four cycles (n = 148) or weekly paclitaxel 80 mg/m2 (1-hour infusion) for 12 weeks (n = 147). All patients underwent a core needle biopsy of the primary cancer for molecular marker analysis prior to chemotherapy. βIII-Tubulin expression was assessed using immunohistochemistry. Results. There was no significant difference in the rate of pCR in the ixabepilone treatment arm (24.3%; 90% confidence interval [CI], 18.6–30.8) and the paclitaxel treatment arm (25.2%; 90% CI, 19.4–31.7). βIII-Tubulin-positive patients obtained higher pCR rates compared with βIII-tubulin-negative patients in both treatment arms; however, βIII-tubulin expression was not significantly associated with a differential response to ixabepilone or paclitaxel. The safety profiles of both regimens were generally similar, although neutropenia occurred more frequently in the ixabepilone arm (grade 3/4: 41.3% vs. 8.4%). The most common nonhematologic toxicity was peripheral neuropathy. Conclusions. Neoadjuvant treatment of early stage BC with AC followed by ixabepilone every 3 weeks or weekly paclitaxel was well tolerated with no significant difference in efficacy. Higher response rates were observed among βIII-tubulin-positive patients. PMID:23853246

  20. Predictive value of PET-CT for pathological response in stages II and III breast cancer patients following neoadjuvant chemotherapy with docetaxel.

    Science.gov (United States)

    García García-Esquinas, Marta A; Arrazola García, Juan; García-Sáenz, José A; Furió-Bacete, V; Fuentes Ferrer, Manuel E; Ortega Candil, Aída; Cabrera Martín, María N; Carreras Delgado, José L

    2014-01-01

    To prospectively study the value of PET-CT with fluorine-18 fluorodeoxyglucose (FDG) to predict neoadjuvant chemotherapy (NAC) response of locoregional disease of stages II and III breast cancer patients. A written informed consent and approval were obtained from the Ethics Committee. PET-CT accuracy in the prediction of pathologic complete response (pCR) after NAC was studied in primary tumors and lymph node metastasis in 43 women (mean age: 50 years: range: 27-71 years) with histologically proven breast cancer between December 2009 and January 2011. PET-CT was performed at baseline and after NAC. SUV(max) percentage changes (ΔSUV(max)) were compared with pathology findings at surgery. Receiver-operator characteristic (ROC) analysis was used to discriminate between locoregional pCR and non-pCR. In patients not achieving pCR, it was investigated if ΔSUV(max) could accurately identify the residual cancer burden (RCB) classes: RCB-I (minimal residual disease (MRD)), RCB-II (moderate RD), and RCB-III (extensive RD). pCR was obtained in 11 patients (25.6%). Residual disease was found in 32 patients (74.4%): 16 (37.2%) RCB-I, 15 (35.6%) RCB-II and 2 (4.7%) RCB-III. Sensitivity, specificity, and accuracy to predict pCR were 90.9%, 90.6%, and 90.7%, respectively. Specificity was 94.1% in the identification of a subset of patients who had either pCR or MRD. Accuracy of ΔSUV(max) in the locoregional disease of stages II and III breast cancer patients after NAC is high for the identification of pCR cases. Its specificity is potentially sufficient to identify a subgroup of patients who could be managed with conservative surgery. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  1. A novel approach to predict the excess volume of hydrocarbon mixtures

    NARCIS (Netherlands)

    Finkers, H. J.; Bosma, J. C.; Broekhuis, A. A.

    2011-01-01

    This paper explores whether principles obtained for the packing of solid macroscopic particles can be applied to the study of excess volumes of liquid mixtures. The approach is applied to mixtures of 'pure' hydrocarbons, i.e. containing only C- and H-atoms. In this new approach a set of equations wa

  2. An evaluation of volume-based morphometry for prediction of mild cognitive impairment and Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Daniel Schmitter

    2015-01-01

    Full Text Available Voxel-based morphometry from conventional T1-weighted images has proved effective to quantify Alzheimer's disease (AD related brain atrophy and to enable fairly accurate automated classification of AD patients, mild cognitive impaired patients (MCI and elderly controls. Little is known, however, about the classification power of volume-based morphometry, where features of interest consist of a few brain structure volumes (e.g. hippocampi, lobes, ventricles as opposed to hundreds of thousands of voxel-wise gray matter concentrations. In this work, we experimentally evaluate two distinct volume-based morphometry algorithms (FreeSurfer and an in-house algorithm called MorphoBox for automatic disease classification on a standardized data set from the Alzheimer's Disease Neuroimaging Initiative. Results indicate that both algorithms achieve classification accuracy comparable to the conventional whole-brain voxel-based morphometry pipeline using SPM for AD vs elderly controls and MCI vs controls, and higher accuracy for classification of AD vs MCI and early vs late AD converters, thereby demonstrating the potential of volume-based morphometry to assist diagnosis of mild cognitive impairment and Alzheimer's disease.

  3. Ovarian volume and antral follicle count for the prediction of low and hyper responders with in vitro fertilization

    Directory of Open Access Journals (Sweden)

    Elting Mariet E

    2007-03-01

    Full Text Available Abstract Background The current study was designed to compare antral follicle count (AFC and basal ovarian volume (BOV, the exogenous FSH ovarian reserve test (EFORT and the clomiphene citrate challenge test (CCCT, with respect to their ability to predict poor and hyper responders. Methods One hundred and ten regularly menstruating patients, aged 18–39 years, participated in this prospective study, randomized, by a computer designed 4-blocks system study into two groups. Fifty six patients underwent a CCCT, and 54 patients underwent an EFORT. All patients underwent a transvaginal sonography to measure the basal ovarian volume and count of basal antral follicle. In all patients, the test was followed by a standard IVF treatment. The result of ovarian hyperstimulation during IVF treatment, expressed by the total number of follicles, was used as gold standard. Results The best prediction of ovarian reserve (Y was seen in a multiple regression prediction model that included, AFC, Inhibin B-increment in the EFORT and BOV simultaneously (Y = -3.161 + 0.805 × AFC (0.258-1.352 + 0.034 × Inh. B-incr. (0.007-0.601 + 0.511 BOV (0.480-0.974 (r = 0.848, p Conclusion In conclusion AFC performs well as a test for ovarian response being superior or at least similar to complex expensive and time consuming endocrine tests. It is therefore likely to be the test for general practise.

  4. Improved prediction of octanol-water partition coefficients from liquid-solute water solubilities and molar volumes

    Science.gov (United States)

    Chiou, C.T.; Schmedding, D.W.; Manes, M.

    2005-01-01

    A volume-fraction-based solvent-water partition model for dilute solutes, in which the partition coefficient shows a dependence on solute molar volume (V??), is adapted to predict the octanol-water partition coefficient (K ow) from the liquid or supercooled-liquid solute water solubility (Sw), or vice versa. The established correlation is tested for a wide range of industrial compounds and pesticides (e.g., halogenated aliphatic hydrocarbons, alkylbenzenes, halogenated benzenes, ethers, esters, PAHs, PCBs, organochlorines, organophosphates, carbamates, and amidesureas-triazines), which comprise a total of 215 test compounds spanning about 10 orders of magnitude in Sw and 8.5 orders of magnitude in Kow. Except for phenols and alcohols, which require special considerations of the Kow data, the correlation predicts the Kow within 0.1 log units for most compounds, much independent of the compound type or the magnitude in K ow. With reliable Sw and V data for compounds of interest, the correlation provides an effective means for either predicting the unavailable log Kow values or verifying the reliability of the reported log Kow data. ?? 2005 American Chemical Society.

  5. Prediction of phycoremediation of As(III) and As(V) from synthetic wastewater by Chlorella pyrenoidosa using artificial neural network

    Science.gov (United States)

    Podder, M. S.; Majumder, C. B.

    2017-03-01

    An artificial neural network (ANN) model was developed to predict the phycoremediation efficiency of Chlorella pyrenoidosa for the removal of both As(III) and As(V) from synthetic wastewater based on 49 data-sets obtained from experimental study and increased the data using CSCF technique. The data were divided into training (60%) validation (20%) and testing (20%) sets. The data collected was used for training a three-layer feed-forward back propagation (BP) learning algorithm having 4-5-1 architecture. The model used tangent sigmoid transfer function at input to hidden layer (tansing) while a linear transfer function (purelin) was used at output layer. Comparison between experimental results and model results gave a high correlation coefficient (R{allANN/2} equal to 0.99987 for both ions and exhibited that the model was able to predict the phycoremediation of As(III) and As(V) from wastewater. Experimental parameters influencing phycoremediation process like pH, inoculum size, contact time and initial arsenic concentration [either As(III) or As(V)] were investigated. A contact time of 168 h was mainly required for achieving equilibrium at pH 9.0 with an inoculum size of 10% (v/v). At optimum conditions, metal ion uptake enhanced with increasing initial metal ion concentration.

  6. Patent Abstract Digest. Volume III.

    Science.gov (United States)

    1981-09-01

    FOR TIlE MULTIPURPOSE 4.122,675 10/1978 Polyak ........................... 60/641 X UTILIZATION OF SOLAR ENERGY FOREIGN PATENT DOCUMENTS 1761 Inventor...contained in Ohio 40"menf .of em W arat thot such use be fro* ffe Pivately owned riht. A 00300 AFSC ar*P7 79c R&LD RECORD (PatentI Abet...., lv PATENT

  7. Meliolales of India - Volume III

    Directory of Open Access Journals (Sweden)

    V.B. Hosagoudar

    2013-04-01

    Full Text Available This work, is the continuation of my preceding two works on Meliolales of India, gives an account of 123 fungal species belonging to five genera, Amazonia (3, Appendiculella (1, Asteridiella (22, Ectendomeliola (1, Irenopsis (8 and Meliola (88, infecting 120 host plants belonging to 49 families. Generic key, digital formula, synoptic key to the species is provided. In the key, all the species are arranged under their alphabetically arranged host families. Description of the individual species is provided with the citation, detailed description, materials examined and their details including their herbarium details. Each species is supplemented with line drawings. Host and the species index is provided at the end. This work includes five new species: Meliola arippaensis, M. calycopteridis, M. cariappae, M. harpullicola and M. mutabilidis; a new variety: Irenopsis hiptages Yamam. Var. indica and two new names: Asteridiella micheliifolia (based on A. micheliae and Meliola strombosiicola (based on Meliola strombosiae

  8. Prediction of the volume flux of the thermal plume above a sitting person

    DEFF Research Database (Denmark)

    Zukowska, Daria; Popiolek, Zbigniew J.; Melikov, Arsen Krikor

    2009-01-01

    The paper presents a verification of a relatively simple method of volume flux calculation applied to the asymmetrical thermal plume generated by a sitting person in a condition of an upward piston flow. The method is based on a model of a thermal plume above a point heat source in an unbounded...... space. The plume volume flux, V, can be calculated based on the following equation: V = kv*Qexp(1/3)*(zt-zv)exp(5/3). In the equation zt is the distance from the measuring plane to the top of the heat source and Qc is the convective part of the heat loss. A value of the entrainment coefficient, kv...

  9. Automated digital volume measurement of melanoma metastases in sentinel nodes predicts disease recurrence and survival

    DEFF Research Database (Denmark)

    Riber-Hansen, Rikke; Nyengaard, Jens R; Hamilton-Dutoit, Stephen J

    2011-01-01

    aim was to investigate whether digital image analysis can estimate TMV accurately in melanoma SLNs. Methods and results: TMV was measured in 147 SLNs from 95 patients both manually and by automated digital image analysis. The results were compared by Bland-Altman plots (numerical data) and kappa......Aims: Total metastatic volume (TMV) is an important prognostic factor in melanoma sentinel lymph nodes (SLNs) that avoids both the interobserver variation and unidirectional upstaging seen when using semi-quantitative size estimates. However, it is somewhat laborious for routine application. Our...... statistics (categorical data). In addition, disease-free and melanoma-specific survivals were calculated. Mean metastatic volume per patient was 10.6 mm(3) (median 0.05 mm(3); range 0.0001-621.3 mm(3)) and 9.62 mm(3) (median 0.05 mm(3); range 0.00001-564.3 mm(3)) with manual and digital measurement...

  10. Mastectomy Weight and Tissue Expander Volume Predict Necrosis and Increased Costs Associated with Breast Reconstruction

    Science.gov (United States)

    Yalanis, Georgia C.; Nag, Shayoni; Georgek, Jakob R.; Cooney, Carisa M.; Manahan, Michele A.; Rosson, Gedge D.

    2015-01-01

    Introduction: Impaired vascular perfusion in tissue expander (TE) breast reconstruction leads to mastectomy skin necrosis. We investigated factors and costs associated with skin necrosis in postmastectomy breast reconstruction. Methods: Retrospective review of 169 women with immediate TE placement following mastectomy between May 1, 2009 and May 31, 2013 was performed. Patient demographics, comorbidities, intraoperative, and postoperative outcomes were collected. Logistic regression analysis on individual variables was performed to determine the effects of tissue expander fill volume and mastectomy specimen weight on skin necrosis. Billing data was obtained to determine the financial burden associated with necrosis. Results: This study included 253 breast reconstructions with immediate TE placement from 169 women. Skin necrosis occurred in 20 flaps for 15 patients (8.9%). Patients with hypertension had 8 times higher odds of skin necrosis [odd ratio (OR), 8.10, P 300 cm3 had 10 times higher odds of skin necrosis (OR, 10.66, P =0.010). Volumes >400 cm3 had 15 times higher odds of skin necrosis (OR, 15.56, P = 0.002). Mastectomy specimen weight was correlated with skin necrosis. Specimens >500 g had 10 times higher odds of necrosis and specimens >1000 g had 18 times higher odds of necrosis (OR, 10.03 and OR, 18.43; P =0.003 and P Mastectomy skin necrosis was associated with a 50% increased inpatient charge. Conclusion: Mastectomy flap necrosis is associated with HTN, larger TE volumes and mastectomy specimen weights, resulting in increased inpatient charges. Conservative TE volumes should be considered for patients with hypertension and larger mastectomy specimens. PMID:26301139

  11. Fractal Prediction of Grouting Volume for Treating Karst Caverns along a Shield Tunneling Alignment

    Directory of Open Access Journals (Sweden)

    Wen-Chieh Cheng

    2017-06-01

    Full Text Available Karst geology is common in China, and buried karst formations are widely distributed in Guangdong province. In the process of shield tunneling, the abundant water resources present in karst caverns could lead to the potential for high water ingress, and a subsequent in situ stress change-induced stratum collapse. The development and distribution of karst caverns should therefore be identified and investigated prior to shield tunnel construction. Grouting is an efficient measure to stabilize karst caverns. The total volume of karst caverns along the shield tunneling alignment, and its relationship with the required volume of grouts, should be evaluated in the preliminary design phase. Conventionally, the total volume of karst caverns is empirically estimated based on limited geological drilling hole data; however, accurate results are rarely obtained. This study investigates the hydrogeology and engineering geology of Guangzhou, the capital of Guangdong province, and determines the fractal characteristics of the karst caverns along the tunnel section of Guangzhou metro line no. 9. The karst grouting coefficients (VR were found to vary from 0.11 in the case of inadequate drilling holes to 1.1 in the case where adequate drilling holes are provided. A grouting design guideline was furthermore developed in this study for future projects in karst areas.

  12. Computational prediction for emission energy of iridium (III) complexes based on TDDFT calculations using exchange-correlation functionals containing various HF exchange percentages.

    Science.gov (United States)

    Xu, Shengxian; Wang, Jinglan; Xia, Hongying; Zhao, Feng; Wang, Yibo

    2015-02-01

    The accurate prediction for the emission energies of the phosphorescent Ir (III) complexes is very useful for the realizing of full-color displays and large-area solid-state lighting in OLED fields. Quantum chemistry calculations based on TDDFT methods are most widely used to directly compute the triplet vertical excitation energies, yet sometimes the universality of these calculations can be limited because of the lack of experimental data for the relative family of structural analogues. In this letter, 16 literature emission energies at low temperature are linearly correlated with their theoretical values computed by TDDFT using exchange-correlation functionals containing various HF exchange percentage with the relation of E exp (em)  = 1.2Ē calc (em). The relation is proven to be robust across a wide range of structures for Ir (III) complexes. These theoretical studies should be expected to provide some guides for the design and synthesis of efficient emitting materials.

  13. Oncotype DX(®) colon cancer assay for prediction of recurrence risk in patients with stage II and III colon cancer: A review of the evidence.

    Science.gov (United States)

    You, Y Nancy; Rustin, Rudolph B; Sullivan, James D

    2015-06-01

    Advances in molecular biology have enabled identification of tumor biomarkers that allow for individualized risk assessment for patients with cancer. Molecular predictors of clinical outcome can help inform discussion regarding the role of adjuvant chemotherapy in patients with resected colon cancer, such as those with stage II colon cancer in which the benefit of adjuvant therapy is controversial or those with stage III colon cancer who may have a lower risk of recurrence and less absolute benefit from oxaliplatin therapy. This article summarizes the data surrounding the development, validation, and clinical and economic utility of the Oncotype DX(®) colon cancer assay, a multigene expression assay validated to independently predict recurrence risk in patients with stage II and III colon cancer beyond traditional factors.

  14. Prognostic significance and predictive performance of volume-based parameters of F-18 FDG PET/CT in squamous cell head and neck cancers

    Directory of Open Access Journals (Sweden)

    Sait Sager

    2014-01-01

    Conclusion: Metabolic tumor volume (MTV represents tumor burden, which shows F18-Fluorodeoxyglucose uptake and has a potential value in predicting short-term outcome and disease-free survival in patients with head and neck cancer.

  15. Predictive value of ischemic lesion volume assessed with magnetic resonance imaging for neurological deficits and functional outcome poststroke: A critical review of the literature.

    NARCIS (Netherlands)

    Schiemanck, S.K.; Kwakkel, G.; Post, M.W.; Prevo, A.J.

    2006-01-01

    OBJECTIVE: Ischemic lesion volume is assumed to be an important predictor of poststroke neurological deficits and functional outcome. This critical review examines the methodological quality of MRI studies and the predictive value of hemispheric infarct volume for neurological deficits (at body

  16. Life prediction methodology for ceramic components of advanced vehicular heat engines: Volume 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Khandelwal, P.K.; Provenzano, N.J.; Schneider, W.E. [Allison Engine Co., Indianapolis, IN (United States)

    1996-02-01

    One of the major challenges involved in the use of ceramic materials is ensuring adequate strength and durability. This activity has developed methodology which can be used during the design phase to predict the structural behavior of ceramic components. The effort involved the characterization of injection molded and hot isostatic pressed (HIPed) PY-6 silicon nitride, the development of nondestructive evaluation (NDE) technology, and the development of analytical life prediction methodology. Four failure modes are addressed: fast fracture, slow crack growth, creep, and oxidation. The techniques deal with failures initiating at the surface as well as internal to the component. The life prediction methodology for fast fracture and slow crack growth have been verified using a variety of confirmatory tests. The verification tests were conducted at room and elevated temperatures up to a maximum of 1371 {degrees}C. The tests involved (1) flat circular disks subjected to bending stresses and (2) high speed rotating spin disks. Reasonable correlation was achieved for a variety of test conditions and failure mechanisms. The predictions associated with surface failures proved to be optimistic, requiring re-evaluation of the components` initial fast fracture strengths. Correlation was achieved for the spin disks which failed in fast fracture from internal flaws. Time dependent elevated temperature slow crack growth spin disk failures were also successfully predicted.

  17. Variability in the Propagation Phase of CFD-Based Noise Prediction: Summary of Results From Category 8 of the BANC-III Workshop

    Science.gov (United States)

    Lopes, Leonard; Redonnet, Stephane; Imamura, Taro; Ikeda, Tomoaki; Zawodny, Nikolas; Cunha, Guilherme

    2015-01-01

    The usage of Computational Fluid Dynamics (CFD) in noise prediction typically has been a two part process: accurately predicting the flow conditions in the near-field and then propagating the noise from the near-field to the observer. Due to the increase in computing power and the cost benefit when weighed against wind tunnel testing, the usage of CFD to estimate the local flow field of complex geometrical structures has become more routine. Recently, the Benchmark problems in Airframe Noise Computation (BANC) workshops have provided a community focus on accurately simulating the local flow field near the body with various CFD approaches. However, to date, little effort has been given into assessing the impact of the propagation phase of noise prediction. This paper includes results from the BANC-III workshop which explores variability in the propagation phase of CFD-based noise prediction. This includes two test cases: an analytical solution of a quadrupole source near a sphere and a computational solution around a nose landing gear. Agreement between three codes was very good for the analytic test case, but CFD-based noise predictions indicate that the propagation phase can introduce 3dB or more of variability in noise predictions.

  18. The Coastal Ocean Prediction Systems program: Understanding and managing our coastal ocean. Volume 1: Strategic summary

    Energy Technology Data Exchange (ETDEWEB)

    1990-05-15

    The proposed COPS (Coastal Ocean Prediction Systems) program is concerned with combining numerical models with observations (through data assimilation) to improve our predictive knowledge of the coastal ocean. It is oriented toward applied research and development and depends upon the continued pursuit of basic research in programs like COOP (Coastal Ocean Processes); i.e., to a significant degree it is involved with ``technology transfer`` from basic knowledge to operational and management applications. This predictive knowledge is intended to address a variety of societal problems: (1) ship routing, (2) trajectories for search and rescue operations, (3) oil spill trajectory simulations, (4) pollution assessments, (5) fisheries management guidance, (6) simulation of the coastal ocean`s response to climate variability, (7) calculation of sediment transport, (8) calculation of forces on structures, and so forth. The initial concern is with physical models and observations in order to provide a capability for the estimation of physical forces and transports in the coastal ocean. For all these applications, there are common needs for physical field estimates: waves, tides, currents, temperature, and salinity, including mixed layers, thermoclines, fronts, jets, etc. However, the intent is to work with biologists, chemists, and geologists in developing integrated multidisciplinary prediction systems as it becomes feasible to do so. From another perspective, by combining observations with models through data assimilation, a modern approach to monitoring is provided through whole-field estimation.

  19. MR Prediction of Liver Function and Pathology Using Gd-EOB-DTPA: Effect of Liver Volume Consideration

    Directory of Open Access Journals (Sweden)

    Dai Shimamoto

    2015-01-01

    Full Text Available Purpose. To evaluate whether the diagnostic performance of Gd-EOB-DTPA-enhanced MRI in evaluating liver function and pathology is improved by considering liver volume (LV. Methods. This retrospective study included 104 patients who underwent Gd-EOB-DTPA-enhanced MRI before liver surgery. For each patient, using the precontrast and hepatobiliary phase images, we calculated the increase rate of the liver-to-spleen signal intensity ratio (LSR, that is, the “ΔLSR,” and the increase rate of the liver-to-muscle signal intensity ratio (LMR, that is, the “ΔLMR.” ΔLSR × LV and ΔLMR × LV were also calculated. The correlation of each MR parameter with liver function data or liver pathology was assessed. The correlation coefficients were compared between ΔLSR (ΔLMR and ΔLSR (ΔLMR × LV. Results. The correlation coefficient between ΔLSR (ΔLMR × LV and cholinesterase was significantly higher than that between ΔLSR (ΔLMR and cholinesterase. The correlation coefficient between ΔLSR (ΔLMR × LV and the degree of fibrosis or necroinflammatory activity was significantly lower than that between ΔLSR (ΔLMR and the degree of fibrosis or necroinflammatory activity. Conclusion. The inclusion of liver volume may improve Gd-EOB-DTPA-based predictions of liver function, but not in predictions of liver pathology.

  20. Preparation of cell blocks for lung cancer diagnosis and prediction: protocol and experience of a high-volume center.

    Science.gov (United States)

    Kossakowski, Claudia A; Morresi-Hauf, Alicia; Schnabel, Philipp A; Eberhardt, Ralf; Herth, Felix J F; Warth, Arne

    2014-01-01

    Minimally invasive diagnostic techniques are increasingly being used to obtain specimens for pathological diagnosis and prediction. Referring to lung cancer, both endobronchial and endoesophageal ultrasound are used worldwide as diagnostic routine methods. Consequently, an increasing number of pathological samples are cytological and fewer are histological. On the other hand, the requirements for specific and sensitive tumor subtyping complemented by predictive analyses are steadily increasing and are an essential basis for evidence-based treatment decisions. In this article we focus on the cell block method as a helpful tool for diagnostic and predictive analyses in lung cancer and point out its advantages and disadvantages in comparison to conventional cytological and biopsy specimens. Furthermore, we retrospectively analyze the diagnostic results of the cell block method in a high-volume center over 5 years. The main advantages of cell blocks are the availability of established and validated protocols, archiving and the opportunity to have serial sections from the same specimens to provide or repeat molecular analyses. Actually, in case of tumor progression, even additional biomarkers can be tested using the original cell block when re-biopsies are not feasible. The cell block method should be considered as a reliable, complimentary approach to conventional cytological or biopsy procedures, which is helpful to fulfill the increasing requirements of high-quality diagnostics and prediction.

  1. Use of pretreatment metabolic tumour volumes to predict the outcome of pharyngeal cancer treated by definitive radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Kao, Chia-Hung [China Medical University Hospital, Department of Nuclear Medicine and PET Center, Taichung (China); China Medical University, Institute of Clinical Medicine Science and School of Medicine, College of Medicine, Taichung (China); China Medical University Hospital, Department of Nuclear Medicine and PET center, Taichung (China); Lin, Shih-Chieh; Wang, Yao-Ching [China Medical University Hospital, Department of Radiation Oncology, Taichung (China); Hsieh, Te-Chun [China Medical University Hospital, Department of Nuclear Medicine and PET Center, Taichung (China); Yen, Kuo-Yang [China Medical University Hospital, Department of Nuclear Medicine and PET Center, Taichung (China); China Medical University, Department of Biomedical Imaging and Radiological Science, Taichung (China); Yang, Shih-Neng [China Medical University Hospital, Department of Radiation Oncology, Taichung (China); China Medical University, Department of Biomedical Imaging and Radiological Science, Taichung (China); Liang, Ji-An [China Medical University Hospital, Department of Radiation Oncology, Taichung (China); China Medical University, Institute of Clinical Medicine Science and School of Medicine, College of Medicine, Taichung (China); Hua, Chun-Hung [China Medical University Hospital, Department of Otorhinolaryngology, Taichung (China); Chen, Shang-Wen [China Medical University Hospital, Department of Radiation Oncology, Taichung (China); China Medical University, Institute of Clinical Medicine Science and School of Medicine, College of Medicine, Taichung (China); Taipei Medical University, Institute of Clinical Medicine Science and School of Medicine, Taipei (China)

    2012-08-15

    The aim of the study was to investigate the predictive role of pretreatment metabolic volume (MTV) in pharyngeal cancer (PC) patients treated with definitive (chemo) radiotherapy. This retrospective analysis enrolled 64 patients with PC treated with (chemo) radiotherapy. All patients received pretreatment fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT. Four PET segmentation methods were used, namely applying an isocontour at a standardized uptake value (SUV) of either 2.5 or 3.0 (MTV2.5 and MTV3.0) or using fixed thresholds of either 40 or 50 % (MTV40 %, MTV50 %) of the maximum intratumoural FDG activity. Disease-free survival (DFS) and primary relapse-free survival (PRFS) were examined according to cutoffs of the median values for each MTV and the gross tumour volume (GTVp). Independent prognosticators were identified by Cox regression analysis. With a median follow-up of 24 months, 19 patients died, and 26 patients experienced tumour relapse at primary sites. Multivariate analysis of the DFS showed that MTV2.5 > 13.6 ml was the only predictor of relapse [p = 0.011, hazard ratio = 2.69, 95 % confidence interval (CI) 1.25-5.76]. The independent predictor for PRFS was MTV2.5 > 13.6 ml (p = 0.003, hazard ratio = 3.76, 95 % CI 1.57-8.92), whereas GTVp > 15.5 ml had a marginal impact on PRFS (p = 0.06, hazard ratio = 3.54, 95 % CI 0.97-11.85). Patients having tumours with MTV2.5 > 13.6 ml had a significantly inferior 2-year PRFS compared with patients who had lower MTV2.5 tumours (39 vs 72 %, respectively, p = 0.001). For PC patients treated with definitive (chemo)radiotherapy, pretreatment MTV2.5 volume achieved the best predictive value for primary recurrence, and the same value was also a prognosticator for DFS. (orig.)

  2. Deviations from Vegard’s law in ternary III-V alloys

    KAUST Repository

    Murphy, S. T.

    2010-08-03

    Vegard’s law states that, at a constant temperature, the volume of an alloy can be determined from a linear interpolation of its constituent’s volumes. Deviations from this description occur such that volumes are both greater and smaller than the linear relationship would predict. Here we use special quasirandom structures and density functional theory to investigate such deviations for MxN1−xAs ternary alloys, where M and N are group III species (B, Al, Ga, and In). Our simulations predict a tendency, with the exception of AlxGa1−xAs, for the volume of the ternary alloys to be smaller than that determined from the linear interpolation of the volumes of the MAs and BAs binary alloys. Importantly, we establish a simple relationship linking the relative size of the group III atoms in the alloy and the predicted magnitude of the deviation from Vegard’s law.

  3. Prediction of distribution volume of vancomycin in critically ill patients using extravascular lung water and pulmonary vascular permeability indices.

    Science.gov (United States)

    Imaura, Masaharu; Yokoyama, Haruko; Kohyama, Tomoki; Nagafuchi, Hiroyuki; Kohata, Yuji; Takahashi, Hiroyuki; Yamada, Yasuhiko

    2012-11-01

    Alterations in distribution volume affect the concentrations of hydrophilic drugs in plasma and tissues at the time of initial therapy. When the distribution volume of hydrophilic antimicrobials is increased in critically ill patients with a serious infection, antimicrobial concentrations are reduced, which may adversely affect the efficacy of antimicrobial therapy. A transpulmonary thermodilution technique system (PiCCO) enables measurements of pulmonary vascular permeability index (PVPI) and extravascular lung water index (EVLWI), which are related to pulmonary edema and pulmonary vascular permeability, respectively. In addition, those indices may also be related to the distribution volume of hydrophilic antimicrobials. The aim of this study was to investigate the relationships of PVPI and EVLWI with the distribution volume of vancomycin (Vss), as well as to establish a method for estimating Vss for planning an appropriate initial dose for individual patients. Seven patients were administered vancomycin intravenously and underwent extended hemodynamic monitoring with the PiCCO system in the intensive care unit (ICU) from April 2009 to March 2011. Vss was calculated using the Bayesian method, and the relationships of PVPI and EVLWI with Vss were investigated. The relationship between Vss/actual body weight (ABW) and median EVLWI on days when blood levels were measured was significant (r = 0.900, p = 0.0057), whereas the relationship between Vss/ABW and PVPI was not significant (r = 0.649, p = 0.1112). EVLWI determined by the PiCCO system is useful to predict Vss and should lead to more effective vancomycin therapy for critically ill patients at the initial stage.

  4. Experimental determination of water activity for binary aqueous cerium(III) ionic solutions: application to an assessment of the predictive capability of the binding mean spherical approximation model.

    Science.gov (United States)

    Ruas, Alexandre; Simonin, Jean-Pierre; Turq, Pierre; Moisy, Philippe

    2005-12-08

    This work is aimed at a description of the thermodynamic properties of actinide salt solutions at high concentration. The predictive capability of the binding mean spherical approximation (BIMSA) theory to describe the thermodynamic properties of electrolytes is assessed in the case of aqueous solutions of lanthanide(III) nitrate and chloride salts. Osmotic coefficients of cerium(III) nitrate and chloride were calculated from other lanthanide(III) salts properties. In parallel, concentrated binary solutions of cerium nitrate were prepared in order to measure experimentally its water activity and density as a function of concentration, at 25 degrees C. Water activities of several binary solutions of cerium chloride were also measured to check existing data on this salt. Then, the properties of cerium chloride and cerium nitrate solutions were compared within the BIMSA model. Osmotic coefficient values for promethium nitrate and promethium chloride given by this theory are proposed. Finally, water activity measurements were made to examine the fact that the ternary system Ce(NO3)3/HNO3/H2O and the quaternary system Ce(NO3)3/HNO3/N2H5NO3/H2O may be regarded as "simple solutions" (in the sense of Zdanovskii and Mikulin).

  5. Parameter Identification for a New Circuit Model Aimed to Predict Body Water Volume

    Directory of Open Access Journals (Sweden)

    GHEORGHE, A.-G.

    2012-11-01

    Full Text Available Intracellular and extracellular water volumes in the human body have been computed using a sequence of models starting with a linear first order RC circuit (Cole model and finishing with the De Lorenzo model. This last model employs a fractional order impedance whose parameters are identified using the frequency characteristics of the impedance module and phase, the latter being not unique. While the Cole model has a two octaves frequency validity range, the De Lorenzo model can be used for three decades. A new linear RC model, valid for a three decades frequency range, is proposed. This circuit can be viewed as an extension of the Cole model for a larger frequency interval, unlike similar models proposed by the same authors.

  6. Blast Noise Prediction. Volume II. BNOISE 3.2 Computer Program Description and Program Listing.

    Science.gov (United States)

    1981-03-01

    spec:itied grid si/c For example, it the x \\alues ofI hounds \\A~ere 20,000 and 4 *Ii1iii ind d i < - vii si/e~ 2000t. thein ihe nev, hounds; ire 20000 ) and...Tor he iied InI L,1LUiing he Itil S I I *I hIre C u ’cFrt I ~ ~ c (hi)I IMJ CS,\\Th can he LISedL Ir t iICUlitirig hW inilti CXjIMSHIf depend1InIfg 01n...0 C - 0 00 0 * 0 NCU’C 04 0 C0 L.LL.J04N0U𔃺 a00W�NN01iCCL.aCLLJ-4U’C.f’-...LO .400C00~- N V ’C SOON CC C P00 ZOU’CONON 20000 -.0,.iOZCZ.W󈧄-.ZN

  7. Prediction of the Soil Water Characteristic from Soil Particle Volume Fractions

    DEFF Research Database (Denmark)

    Naveed, Muhammad; Møldrup, Per; Tuller, Markus

    2012-01-01

    Modelling water distribution and flow in partially saturated soils requires knowledge of the soil-water characteristic (SWC). However, measurement of the SWC is challenging and time-consuming, and in some cases not feasible. This study introduces two predictive models (Xw-model and Xw......*-model) for the SWC, derived from readily available soil properties such as texture and bulk density. A total of 46 soils from different horizons at 15 locations across Denmark were used for models evaluation. The Xw-model predicts the volumetric water content as a function of volumetric fines content (organic matter...... (organic matter, clay, silt, fine and coarse sand), variably included in the model depending on the pF value. The volumetric content of a particular soil particle size fraction was included in the model if it was assumed to contribute to the pore size fraction still occupied with water at the given p...

  8. Review of methods for predicting in situ volume change movement of expansive soil over time

    OpenAIRE

    Hana H. Adem; Sai K. Vanapalli

    2015-01-01

    The soil movement information over time is required for the design of foundations placed in expansive soils. This information is also helpful for the assessment of pre-wetting and controlled wetting mitigation alternatives for expansive soils. Several researchers during the past fifteen years have proposed different methods for the prediction of the soil movements over time. The available methods can be categorized into (i) consolidation theory-based methods, (ii) water content-based methods,...

  9. Proceedings of the International Conference on the Psychology of Mathematics Education (PME) (11th, Montreal, Canada, July 19-25, 1987). Volumes I-III.

    Science.gov (United States)

    Bergeron, Jacques C., Ed.; And Others

    The Proceedings of PME-XI has been published in three separate volumes because of the large total of 161 individual conference papers reported. Volume I contains four plenary papers, all on the subject of "constructivism," and 44 commented papers arranged under 4 themes. Volume II contains 56 papers (39 commented; 17 uncommented)…

  10. Proceedings of the International Conference on the Psychology of Mathematics Education (PME) (17th, Tsukuba, Japan, July 18-23, 1993). Volumes I-III.

    Science.gov (United States)

    Hirabayashi, Ichiei, Ed.; And Others

    The Proceedings of PME-XVII has been published in three volumes because of the large number of papers presented at the conference. Volume I contains a brief Plenary Panel report, 4 full-scale Plenary Addresses, the brief reports of 10 Working Groups and 4 Discussion Groups, and a total of 23 Research Reports grouped under 4 themes. Volume II…

  11. Lagrangian and Control Volume Models for Prediction of Cooling Lake Performance at SRP

    Energy Technology Data Exchange (ETDEWEB)

    Garrett, A.J.

    2001-06-26

    The model validation described in this document indicates that the methods described here and by Cooper (1984) for predicting the performance of the proposed L-Area cooling lake are reliable. Extensive observations from the Par Pond system show that lake surface temperatures exceeding 32.2 degrees C (90 degrees F) are attained occasionally in the summer in areas where there is little or no heating from the P-Area Reactor. Regulations which restrict lake surface temperatures to less than 32.2 degrees C should be structured to allow for these naturally-occurring thermal excursions.

  12. Prediction by Artificial Neural Networks (ANN of the diffusivity, mass, moisture, volume and solids on osmotically dehydrated yacon (Smallantus sonchifolius

    Directory of Open Access Journals (Sweden)

    Julio Rojas Naccha

    2012-09-01

    Full Text Available The predictive ability of Artificial Neural Network (ANN on the effect of the concentration (30, 40, 50 y 60 % w/w and temperature (30, 40 y 50°C of fructooligosaccharides solution, in the mass, moisture, volume and solids of osmodehydrated yacon cubes, and in the coefficients of the water means effective diffusivity with and without shrinkage was evaluated. The Feedforward type ANN with the Backpropagation training algorithms and the Levenberg-Marquardt weight adjustment was applied, using the following topology: 10-5 goal error, 0.01 learning rate, 0.5 moment coefficient, 2 input neurons, 6 output neurons, one hidden layer with 18 neurons, 15 training stages and logsig-pureline transfer functions. The overall average error achieved by the ANN was 3.44% and correlation coefficients were bigger than 0.9. No significant differences were found between the experimental values and the predicted values achieved by the ANN and with the predicted values achieved by a statistical model of second-order polynomial regression (p > 0.95.

  13. Pattern not volume of bleeding predicts angiographic vasospasm in nonaneurysmal subarachnoid hemorrhage.

    Science.gov (United States)

    Raya, Amanda; Zipfel, Gregory J; Diringer, Michael N; Dacey, Ralph G; Derdeyn, Colin P; Rich, Keith M; Chicoine, Michael R; Dhar, Rajat

    2014-01-01

    Spontaneous idiopathic subarachnoid hemorrhage (SAH) with a perimesencephalic bleeding pattern is usually associated with a benign course, whereas a diffuse bleeding pattern has been associated with a higher risk of vasospasm and disability. We evaluated whether volume of bleeding explains this disparity. Pattern and amount of bleeding (by Hijdra and intraventricular hemorrhage scores) were assessed in 89 patients with nonaneurysmal SAH. Outcomes included angiographic vasospasm, delayed cerebral ischemia, and functional outcome at 1 year. Diffuse bleeding was associated with significantly higher Hijdra and intraventricular hemorrhage scores than perimesencephalic SAH, P≤0.003. Angiographic vasospasm was more likely in diffuse versus perimesencephalic SAH (45% versus 27%; odds ratio, 2.9; P=0.08), but adjustment for greater blood burden only partially attenuated this trend (adjusted odds ratio, 2.2; 95% confidence interval, 0.69-7.2; P=0.18); delayed cerebral ischemia was only seen in those with diffuse bleeding. Patients with diffuse bleeding were less likely to be discharged home (68% versus 90%; P=0.01) and tended to have more residual disability (modified Rankin scale, 3-6; 20% versus 6%; P=0.18). Nonaneurysmal SAH can still result in vasospasm and residual disability, especially in those with diffuse bleeding. This disparity is only partially accounted for by greater cisternal or intraventricular blood, suggesting that the mechanism and distribution of bleeding may be as important as the amount of hemorrhage in patients with idiopathic SAH.

  14. Functional and computational analysis of amino acid patterns predictive of type III secretion system substrates in Pseudomonas syringae.

    Directory of Open Access Journals (Sweden)

    Lisa M Schechter

    Full Text Available Bacterial type III secretion systems (T3SSs deliver proteins called effectors into eukaryotic cells. Although N-terminal amino acid sequences are required for translocation, the mechanism of substrate recognition by the T3SS is unknown. Almost all actively deployed T3SS substrates in the plant pathogen Pseudomonas syringae pathovar tomato strain DC3000 possess characteristic patterns, including (i greater than 10% serine within the first 50 amino acids, (ii an aliphatic residue or proline at position 3 or 4, and (iii a lack of acidic amino acids within the first 12 residues. Here, the functional significance of the P. syringae T3SS substrate compositional patterns was tested. A mutant AvrPto effector protein lacking all three patterns was secreted into culture and translocated into plant cells, suggesting that the compositional characteristics are not absolutely required for T3SS targeting and that other recognition mechanisms exist. To further analyze the unique properties of T3SS targeting signals, we developed a computational algorithm called TEREE (Type III Effector Relative Entropy Evaluation that distinguishes DC3000 T3SS substrates from other proteins with a high sensitivity and specificity. Although TEREE did not efficiently identify T3SS substrates in Salmonella enterica, it was effective in another P. syringae strain and Ralstonia solanacearum. Thus, the TEREE algorithm may be a useful tool for identifying new effector genes in plant pathogens. The nature of T3SS targeting signals was additionally investigated by analyzing the N-terminus of FtsX, a putative membrane protein that was classified as a T3SS substrate by TEREE. Although the first 50 amino acids of FtsX were unable to target a reporter protein to the T3SS, an AvrPto protein substituted with the first 12 amino acids of FtsX was translocated into plant cells. These results show that the T3SS targeting signals are highly mutable and that secretion may be directed by multiple

  15. Prediction of outcome from intensive care: a prospective cohort study comparing Acute Physiology and Chronic Health Evaluation II and III prognostic systems in a United Kingdom intensive care unit.

    Science.gov (United States)

    Beck, D H; Taylor, B L; Millar, B; Smith, G B

    1997-01-01

    To evaluate the ability of two prognostic systems to predict hospital mortality in adult intensive care patients. Prospective cohort study. A mixed medical and surgical intensive care unit (ICU) in the United Kingdom. A total of 1,144 patients consecutively admitted to the study. None. Acute Physiology and Chronic Health Evaluation (APACHE) II and III prognostic systems were applied to assess probabilities of hospital mortality, which were compared with the actual outcome. The overall goodness-of-fit of both models was assessed. Hospital death rates were higher than those predicted by each system. Risk estimates showed a strong positive correlation between both systems (nonsurvivors r2 = 0.756, p best overall total correct classification rate was 80.6% for APACHE III and 77.9% for APACHE II (both for a decision criterion of 40%). The areas under the receiver operating characteristic curves were 0.806 and 0.847 for APACHE II and III, respectively, confirming the better discrimination of APACHE III. When patients were classified by diagnostic categories, risk predictions did not fit uniformly across the spectrum of disease groups. For both models, mortality ratios were highest for trauma patients and lowest for the group with respiratory disease. APACHE II predictions for patients with gastrointestinal disease were significantly better. Risk estimates for surgical admissions were superior with APACHE II (MR = 1.27) compared with APACHE III (MR = 1.56), but were similar for medical patients (1.22 vs. 1.28 for APACHE II and III, respectively). Bias induced by factors reflecting the clinical practice in an individual ICU (e.g., admission criteria, treatment before admission) may have considerable impact on risk estimates. The identification of such factors appears to be a prerequisite for the meaningful interpretation of observed and predicted death rates on the individual ICU level. Both predictive models demonstrated a similar degree of overall goodness-of-fit. APACHE

  16. User's manual for MODCAL: Bounding surface soil plasticity model calibration and prediction code, volume 2

    Science.gov (United States)

    Dennatale, J. S.; Herrmann, L. R.; Defalias, Y. F.

    1983-02-01

    In order to reduce the complexity of the model calibration process, a computer-aided automated procedure has been developed and tested. The computer code employs a Quasi-Newton optimization strategy to locate that set of parameter values which minimizes the discrepancy between the model predictions and the experimental observations included in the calibration data base. Through application to a number of real soils, the automated procedure has been found to be an efficient, reliable and economical means of accomplishing model calibration. Although the code was developed specifically for use with the Bounding Surface plasticity model, it can readily be adapted to other constitutive formulations. Since the code greatly reduces the dependence of calibration success on user expertise, it significantly increases the accessibility and usefulness of sophisticated material models to the general engineering community.

  17. Left atrial volume predicts adverse cardiac and cerebrovascular events in patients with hypertrophic cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Tani Tomoko

    2011-11-01

    Full Text Available Abstract Aims To prospectively evaluate the relationship between left atrial volume (LAV and the risk of clinical events in patients with hypertrophic cardiomyopathy (HCM. Methods We enrolled a total of 141 HCM patients with sinus rhythm and normal pump function, and 102 patients (73 men; mean age, 61 ± 13 years who met inclusion criteria were followed for 30.8 ± 10.0 months. The patients were divided into two groups with or without major adverse cardiac and cerebrovascular events (MACCE, a composite of stroke, sudden death, and congestive heart failure. Detailed clinical and echocardiographic data were obtained. Results MACCE occurred in 24 patients (18 strokes, 4 congestive heart failure and 2 sudden deaths. Maximum LAV, minimum LAV, and LAV index (LAVI corrected for body surface area (BSA were significantly greater in patients with MACCE than those without MACCE (maximum LAV: 64.3 ± 25.0 vs. 51.9 ± 16.0 ml, p = 0.005; minimum LAV: 33.9 ± 15.1 vs. 26.2 ± 10.9 ml, p = 0.008; LAVI: 40.1 ± 15.4 vs. 31.5 ± 8.7 ml/mm2, p = 0.0009, while there were no differences in the other echocardiographic parameters. LAV/BSA of ≥ 40.4 ml/m2 to identify patients with cardiovascular complications with a sensitivity of 73% and a specificity of 88%. Conclusion LAVI may be an effective marker for detecting the risk of MACCE in patients with HCM and normal pump function.

  18. FDG-PET Response Prediction in Pediatric Hodgkin’s Lymphoma: Impact of Metabolically Defined Tumor Volumes and Individualized SUV Measurements on the Positive Predictive Value

    Energy Technology Data Exchange (ETDEWEB)

    Hussien, Amr Elsayed M. [Department of Nuclear Medicine (KME), Forschungszentrum Jülich, Medical Faculty, Heinrich-Heine-University Düsseldorf, Jülich, 52426 (Germany); Department of Nuclear Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, 40225 (Germany); Furth, Christian [Department of Radiology and Nuclear Medicine, Medical School, Otto-von-Guericke University Magdeburg, Magdeburg, 39120 (Germany); Schönberger, Stefan [Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, 40225 (Germany); Hundsdoerfer, Patrick [Department of Pediatric Oncology and Hematology, Charité Campus Virchow, Humboldt-University Berlin, Berlin, 13353 (Germany); Steffen, Ingo G.; Amthauer, Holger [Department of Radiology and Nuclear Medicine, Medical School, Otto-von-Guericke University Magdeburg, Magdeburg, 39120 (Germany); Müller, Hans-Wilhelm; Hautzel, Hubertus, E-mail: h.hautzel@fz-juelich.de [Department of Nuclear Medicine (KME), Forschungszentrum Jülich, Medical Faculty, Heinrich-Heine-University Düsseldorf, Jülich, 52426 (Germany); Department of Nuclear Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, 40225 (Germany)

    2015-01-28

    Background: In pediatric Hodgkin’s lymphoma (pHL) early response-to-therapy prediction is metabolically assessed by (18)F-FDG PET carrying an excellent negative predictive value (NPV) but an impaired positive predictive value (PPV). Aim of this study was to improve the PPV while keeping the optimal NPV. A comparison of different PET data analyses was performed applying individualized standardized uptake values (SUV), PET-derived metabolic tumor volume (MTV) and the product of both parameters, termed total lesion glycolysis (TLG); Methods: One-hundred-eight PET datasets (PET1, n = 54; PET2, n = 54) of 54 children were analysed by visual and semi-quantitative means. SUVmax, SUVmean, MTV and TLG were obtained the results of both PETs and the relative change from PET1 to PET2 (Δ in %) were compared for their capability of identifying responders and non-responders using receiver operating characteristics (ROC)-curves. In consideration of individual variations in noise and contrasts levels all parameters were additionally obtained after threshold correction to lean body mass and background; Results: All semi-quantitative SUV estimates obtained at PET2 were significantly superior to the visual PET2 analysis. However, ΔSUVmax revealed the best results (area under the curve, 0.92; p < 0.001; sensitivity 100%; specificity 85.4%; PPV 46.2%; NPV 100%; accuracy, 87.0%) but was not significantly superior to SUVmax-estimation at PET2 and ΔTLGmax. Likewise, the lean body mass and background individualization of the datasets did not impove the results of the ROC analyses; Conclusions: Sophisticated semi-quantitative PET measures in early response assessment of pHL patients do not perform significantly better than the previously proposed ΔSUVmax. All analytical strategies failed to improve the impaired PPV to a clinically acceptable level while preserving the excellent NPV.

  19. FDG-PET Response Prediction in Pediatric Hodgkin’s Lymphoma: Impact of Metabolically Defined Tumor Volumes and Individualized SUV Measurements on the Positive Predictive Value

    Directory of Open Access Journals (Sweden)

    Amr Elsayed M. Hussien

    2015-01-01

    Full Text Available Background: In pediatric Hodgkin’s lymphoma (pHL early response-to-therapy prediction is metabolically assessed by (18F-FDG PET carrying an excellent negative predictive value (NPV but an impaired positive predictive value (PPV. Aim of this study was to improve the PPV while keeping the optimal NPV. A comparison of different PET data analyses was performed applying individualized standardized uptake values (SUV, PET-derived metabolic tumor volume (MTV and the product of both parameters, termed total lesion glycolysis (TLG; Methods: One-hundred-eight PET datasets (PET1, n = 54; PET2, n = 54 of 54 children were analysed by visual and semi-quantitative means. SUVmax, SUVmean, MTV and TLG were obtained the results of both PETs and the relative change from PET1 to PET2 (Δ in % were compared for their capability of identifying responders and non-responders using receiver operating characteristics (ROC-curves. In consideration of individual variations in noise and contrasts levels all parameters were additionally obtained after threshold correction to lean body mass and background; Results: All semi-quantitative SUV estimates obtained at PET2 were significantly superior to the visual PET2 analysis. However, ΔSUVmax revealed the best results (area under the curve, 0.92; p < 0.001; sensitivity 100%; specificity 85.4%; PPV 46.2%; NPV 100%; accuracy, 87.0% but was not significantly superior to SUVmax-estimation at PET2 and ΔTLGmax. Likewise, the lean body mass and background individualization of the datasets did not impove the results of the ROC analyses; Conclusions: Sophisticated semi-quantitative PET measures in early response assessment of pHL patients do not perform significantly better than the previously proposed ΔSUVmax. All analytical strategies failed to improve the impaired PPV to a clinically acceptable level while preserving the excellent NPV.

  20. CTA collateral score predicts infarct volume and clinical outcome after endovascular therapy for acute ischemic stroke: a retrospective chart review.

    Science.gov (United States)

    Elijovich, Lucas; Goyal, Nitin; Mainali, Shraddha; Hoit, Dan; Arthur, Adam S; Whitehead, Matthew; Choudhri, Asim F

    2016-06-01

    Acute ischemic stroke (AIS) due to emergent large-vessel occlusion (ELVO) has a poor prognosis. To examine the hypothesis that a better collateral score on pretreatment CT angiography (CTA) would correlate with a smaller final infarct volume and a more favorable clinical outcome after endovascular therapy (EVT). A retrospective chart review of the University of Tennessee AIS database from February 2011 to February 2013 was conducted. All patients with CTA-proven LVO treated with EVT were included. Recanalization after EVT was defined by Thrombolysis in Cerebral Infarction (TICI) score ≥2. Favorable outcome was assessed as a modified Rankin Score ≤3. Fifty patients with ELVO were studied. The mean National Institutes of Health Stroke Scale score was 17 (2-27) and 38 of the patients (76%) received intravenous tissue plasminogen activator. The recanalization rate for EVT was 86.6%. Good clinical outcome was achieved in 32% of patients. Univariate predictors of good outcome included good collateral scores (CS) on presenting CTA (p=0.043) and successful recanalization (p=0.02). Multivariate analysis confirmed both good CS (p=0.024) and successful recanalization (p=0.009) as predictors of favorable outcome. Applying results of the multivariate analysis to our cohort we were able to determine the likelihood of good clinical outcome as well as predictors of smaller final infarct volume after successful recanalization. Good CS predict smaller infarct volumes and better clinical outcome in patients recanalized with EVT. These data support the use of this technique in selecting patients for EVT. Poor CS should be considered as an exclusion criterion for EVT as patients with poor CS have poor clinical outcomes despite recanalization. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  1. Generation of predictive price and trading volume patterns in a model of dynamically evolving free market supply and demand

    Directory of Open Access Journals (Sweden)

    J. K. Wang

    2001-01-01

    Full Text Available I present a model of stock market price fluctuations incorporating effects of share supply as a history-dependent function of previous purchases and share demand as a function of price deviation from moving averages. Price charts generated show intervals of oscillations switching amplitude and frequency suddenly in time, forming price and trading volume patterns well-known in market technical analysis. Ultimate price trends agree with traditional predictions for specific patterns. The consideration of dynamically evolving supply and demand in this model resolves the apparent contradiction with the Efficient Market Hypothesis: perceptions of imprecise equity values by a world of investors evolve over non-negligible periods of time, with dependence on price history.

  2. Significant correlation between spleen volume and thrombocytopenia in liver transplant patients: a concept for predicting persistent thrombocytopenia.

    Science.gov (United States)

    Ohira, Masahiro; Ishifuro, Minoru; Ide, Kentaro; Irei, Toshimitsu; Tashiro, Hirotaka; Itamoto, Toshiyuki; Ito, Katsuhide; Chayama, Kazuaki; Asahara, Toshimasa; Ohdan, Hideki

    2009-02-01

    Interferon (IFN) therapy with or without ribavirin treatment is well established as a standard antiviral treatment for hepatitis C virus (HCV)-infected patients. However, susceptibility to thrombocytopenia is a major obstacle for initiating or continuing this therapy, particularly in liver transplant (LTx) recipients with HCV. Studies have reported that splenectomy performed concurrently with LTx is a feasible strategy for conditioning patients for anti-HCV IFN therapy. However, the relationship between the severity of splenomegaly and alterations in the blood cytopenia in LTx recipients remains to be clarified. Here, we analyzed the relationship between spleen volume (SV) and thrombocytopenia in 45 patients who underwent LTx at Hiroshima University Hospital. The extent of pre-LTx splenomegaly [the SV to body surface area (BSA) ratio in an individual] was inversely correlated with both the post-LTx white blood cell count and platelet (PLT) count (P or= 400), persistent thrombocytopenia is predictable after LTx.

  3. Intermediate volume on computed tomography imaging defines a fibrotic compartment that predicts glomerular filtration rate decline in autosomal dominant polycystic kidney disease patients.

    Science.gov (United States)

    Caroli, Anna; Antiga, Luca; Conti, Sara; Sonzogni, Aurelio; Fasolini, Giorgio; Ondei, Patrizia; Perico, Norberto; Remuzzi, Giuseppe; Remuzzi, Andrea

    2011-08-01

    Total kidney and cyst volumes have been used to quantify disease progression in autosomal dominant polycystic kidney disease (ADPKD), but a causal relationship with progression to renal failure has not been demonstrated. Advanced image processing recently allowed to quantify extracystic tissue, and to identify an additional tissue component named "intermediate," appearing hypoenhanced on contrast-enhanced computed tomography (CT). The aim of this study is to provide a histological characterization of intermediate volume, investigate its relation with renal function, and provide preliminary evidence of its role in long-term prediction of functional loss. Three ADPKD patients underwent contrast-enhanced CT scans before nephrectomy. Histological samples of intermediate volume were drawn from the excised kidneys, and stained with hematoxylin and eosin and with saturated picrosirius solution for histological analysis. Intermediate volume showed major structural changes, characterized by tubular dilation and atrophy, microcysts, inflammatory cell infiltrate, vascular sclerosis, and extended peritubular interstitial fibrosis. A significant correlation (r = -0.69, P < 0.001) between relative intermediate volume and baseline renal function was found in 21 ADPKD patients. Long-term prediction of renal functional loss was investigated in an independent cohort of 13 ADPKD patients, followed for 3 to 8 years. Intermediate volume, but not total kidney or cyst volume, significantly correlated with glomerular filtration rate decline (r = -0.79, P < 0.005). These findings suggest that intermediate volume may represent a suitable surrogate marker of ADPKD progression and a novel therapeutic target.

  4. Statistical simulations to estimate motion-inclusive dose-volume histograms for prediction of rectal morbidity following radiotherapy

    Science.gov (United States)

    THOR, MARIA; APTE, ADITYA; DEASY, JOSEPH O.; MUREN, LUDVIG PAUL

    2016-01-01

    Background and purpose Internal organ motion over a course of radiotherapy (RT) leads to uncertainties in the actual delivered dose distributions. In studies predicting RT morbidity, the single estimate of the delivered dose provided by the treatment planning computed tomography (pCT) is typically assumed to be representative of the dose distribution throughout the course of RT. In this paper, a simple model for describing organ motion is introduced, and is associated to late rectal morbidity data, with the aim of improving morbidity prediction. Material and methods Organ motion was described by normally distributed translational motion, with its magnitude characterised by the standard deviation (SD) of this distribution. Simulations of both isotropic and anisotropic (anterior-posterior only) motion patterns were performed, as were random, systematic or combined random and systematic motion. The associations between late rectal morbidity and motion-inclusive delivered dose-volume histograms (dDVHs) were quantified using Spearman's rank correlation coefficient (Rs) in a series of 232 prostate cancer patients, and were compared to the associations obtained with the static/planned DVH (pDVH). Results For both isotropic and anisotropic motion, different associations with rectal morbidity were seen with the dDVHs relative to the pDVHs. The differences were most pronounced in the mid-dose region (40–60 Gy). The associations were dependent on the applied motion patterns, with the strongest association with morbidity obtained by applying random motion with an SD in the range 0.2–0.8 cm. Conclusion In this study we have introduced a simple model for describing organ motion occurring during RT. Differing and, for some cases, stronger dose-volume dependencies were found between the motion-inclusive dose distributions and rectal morbidity as compared to the associations with the planned dose distributions. This indicates that rectal organ motion during RT influences the

  5. Predicting Individualized Postoperative Survival for Stage II/III Colon Cancer Using a Mobile Application Derived from the National Cancer Data Base

    Science.gov (United States)

    Gabriel, Emmanuel; Attwood, Kristopher; Thirunavukarasu, Pragatheeshwar; Al-Sukhni, Eisar; Boland, Patrick; Nurkin, Steven

    2017-01-01

    BACKGROUND Prediction calculators estimate postoperative survival and assist the decision-making process for adjuvant treatment. The objective of this study was to create a postoperative overall survival (OS) calculator for patients with stage II/III colon cancer. Factors that influence OS, including comorbidity and postoperative variables, were included. STUDY DESIGN The National Cancer Data Base was queried for patients with stage II/III colon cancer, diagnosed between 2004 and 2006, who had surgical resection. Patients were randomly divided to a testing (nt) cohort comprising 80% of the dataset and a validation (nv) cohort comprising 20%. Multivariable Cox proportional hazards regression of nt was performed to identify factors associated with 5-year OS. These were used to build a prediction model. The performance was assessed using the nv cohort and translated into mobile software. RESULTS A total of 129,040 patients had surgery. After exclusion of patients with carcinoma in situ, non-adenocarcinoma histology, more than 1 malignancy, stage I or IV disease, or missing data, 34,176 patients were used in the development of the calculator. Independent predictors of OS included patient-specific characteristics, pathologic factors, and treatment options, including type of surgery and adjuvant therapy. Length of postoperative stay and unplanned readmission rates were also incorporated as surrogates for postoperative complications (1-day increase in postoperative stay, hazard ratio [HR] 1.019, 95% CI 1.018 to 1.021, p cancer. This prediction model uses nationwide data, culminating in a highly comprehensive, clinically useful tool. PMID:26922599

  6. Multiple Off-Ice Performance Variables Predict On-Ice Skating Performance in Male and Female Division III Ice Hockey Players

    Directory of Open Access Journals (Sweden)

    effrey M. Janot, Nicholas M. Beltz, Lance D. Dalleck

    2015-09-01

    Full Text Available The purpose of this study was to determine if off-ice performance variables could predict on-ice skating performance in Division III collegiate hockey players. Both men (n = 15 and women (n = 11 hockey players (age = 20.5 ± 1.4 years participated in the study. The skating tests were agility cornering S-turn, 6.10 m acceleration, 44.80 m speed, modified repeat skate, and 15.20 m full speed. Off-ice variables assessed were years of playing experience, height, weight and percent body fat and off-ice performance variables included vertical jump (VJ, 40-yd dash (36.58m, 1-RM squat, pro-agility, Wingate peak power and peak power percentage drop (% drop, and 1.5 mile (2.4km run. Results indicated that 40-yd dash (36.58m, VJ, 1.5 mile (2.4km run, and % drop were significant predictors of skating performance for repeat skate (slowest, fastest, and average time and 44.80 m speed time, respectively. Four predictive equations were derived from multiple regression analyses: 1 slowest repeat skate time = 2.362 + (1.68 x 40-yd dash time + (0.005 x 1.5 mile run, 2 fastest repeat skate time = 9.762 - (0.089 x VJ - (0.998 x 40-yd dash time, 3 average repeat skate time = 7.770 + (1.041 x 40-yd dash time - (0.63 x VJ + (0.003 x 1.5 mile time, and 4 47.85 m speed test = 7.707 - (0.050 x VJ - (0.01 x % drop. It was concluded that selected off-ice tests could be used to predict on-ice performance regarding speed and recovery ability in Division III male and female hockey players.

  7. SU-E-T-430: Feasibility Study On Using Overlap Volume Histogram to Predict the Dose Difference by Respiratory Motion

    Energy Technology Data Exchange (ETDEWEB)

    Shin, D; Kang, S; Kim, D; Kim, T; Kim, K; Cho, M; Suh, T [The Catholic University of Korea, Seoul (Korea, Republic of)

    2015-06-15

    Purpose: The dose difference between three-dimensional dose (3D dose) and 4D dose which considers motion due to respiratory can be varied according to geometrical relationship between planning target volume (PTV) and organ at risk (OAR). The purpose of the study is to investigate the dose difference between 3D and 4D dose using overlap volume histogram (OVH) which is an indicator that quantify geometrical relationship between a PTV and an OAR. Methods: Five liver cancer patients who previously treated stereotactic body radiotherapy (SBRT) were investigated. Four-dimensional computed tomography (4DCT) images were acquired for all patients. ITV-based treatment planning was performed. 3D dose was calculated on the end-exhale phase image as a reference phase image. 4D dose accumulation was implemented from all phase images using dose warping technique used deformable image registration (DIR) algorithm (Horn and Schunck optical flow) in DIRART. In this study OVH was used to quantify geometrical relationship between a PTV and an OAR. OVH between a PTV and a selected OAR was generated for each patient case and compared for all cases. The dose difference between 3D and 4D dose for normal organ was calculated and compared for all cases according to OVH. Results: The 3D and 4D dose difference for OAR was analyzed using dose-volume histogram (DVH). On the basis of a specific point which corresponds to 10% of OAR volume overlapped with expanded PTV, mean dose difference was 34.56% in minimum OVH distance case and 13.36% in maximum OVH distance case. As the OVH distance increased, mean dose difference between 4D and 3D dose was decreased. Conclusion: The tendency of dose difference variation was verified according to OVH. OVH is seems to be indicator that has a potential to predict the dose difference between 4D and 3D dose. This work was supported by the Radiation Technology R&D program (No. 2013M2A2A7043498) and the Mid-career Researcher Program (2014R1A2A1A10050270) through

  8. Prediction of Freight Transport Impacts on Urban Road Volumes: A Case Study of Izmir

    Directory of Open Access Journals (Sweden)

    Yıldırım Oral

    2013-06-01

    Full Text Available Planning paradigms, which aim to overcome urban transport problems, have to evaluate the mobility prediction of goods besides the mobility of individuals. This is a requirement and it comes up with different scales and features in the cities which contain high density of regional interactions. Urban roads respond from freight transport due to economy besides relation of productions and consumptions. This study is an instance to generate solutions for future which tries to evaluate respective interaction in the process of urban planning and transport planning. Study area has been stated as the city Izmir, TURKEY. The exact area is the legal responsibility border of the law 3030. The location and impact of freight transport generation stations cause total freight transport demands to rise up. Concurrently, there is a high ratio of freight transport in the transit traffic. Freight vehicles may be seen in every level of roads due to features of the road network. Therefore, it has been aimed to correlate freight transport moves with the location and impacts of the freight generation stations. This study also assumes that freight transport moves may have some measurable reasons and may contain usable parameters, for this purpose. The measurement of freight transport in Izmir, the density of the vehicles which interacts with the several aggregation areas and the location or impacts of the freight transport generation stations in those areas have been tried to evaluate simultaneously. The stages of the paradigm are determined as below: • To determine the categories of the freight transport generation stations and measurement values on urban roads,• To draw the borders of several aggregations areas and CBD area borders by determining enumeration points,• To measure density of freight vehicles move in terms of inner traffic,

  9. SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II–III Diffuse Gliomas

    Directory of Open Access Journals (Sweden)

    Yu-An Zhang

    2016-11-01

    Interpretation: We have identified that SHOX2 expression or methylation are potent independent prognostic indicators for predicting LGG patient survival, and have potential to identify an important subset of LGG patients with IDHwt status with significantly better overall survival. The combination of IDH or other relevant markers with SHOX2 identified LGG subsets with significantly different survival outcomes, and further understanding of these subsets may benefit therapeutic target identification and therapy selections for glioma patients.

  10. A predictive model to guide management of the overlap region between target volume and organs at risk in prostate cancer volumetric modulated arc therapy

    Energy Technology Data Exchange (ETDEWEB)

    Mattes, Malcolm D.; Lee, Jennifer C.; Einaiem, Sara; Guirguis, Adel; Ikoro, N. C.; Ashamalla Hani [Dept. of Radiation Oncology, New York Methodist Hospital, Brooklyn (United States)

    2013-12-15

    The goal of this study is to determine whether the magnitude of overlap between planning target volume (PTV) and rectum (Rectum{sub overlap}) or PTV and bladder (Bladder{sub overlap}) in prostate cancer volumetric-modulated arc therapy (VMAT) is predictive of the dose-volume relationships achieved after optimization, and to identify predictive equations and cutoff values using these overlap volumes beyond which the Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC) dose-volume constraints are unlikely to be met. Fifty-seven patients with prostate cancer underwent VMAT planning using identical optimization conditions and normalization. The PTV (for the 50.4 Gy primary plan and 30.6 Gy boost plan) included 5 to 10 mm margins around the prostate and seminal vesicles. Pearson correlations, linear regression analyses, and receiver operating characteristic (ROC) curves were used to correlate the percentage overlap with dose-volume parameters. The percentage Rectum{sub overlap} and Bladder{sub overlap} correlated with sparing of that organ but minimally impacted other dose-volume parameters, predicted the primary plan rectum V{sub 45} and bladder V{sub 50} with R{sup 2} = 0.78 and R{sup 2} = 0.83, respectively, and predicted the boost plan rectum V{sub 30} and bladder V{sub 30} with R{sup 2} = 0.53 and R{sup 2} = 0.81, respectively. The optimal cutoff value of boost Rectumoverlap to predict rectum V75 >15% was 3.5% (sensitivity 100%, specificity 94%, p < 0.01), and the optimal cutoff value of boost Bladder{sub overlap} to predict bladder V{sub 80} >10% was 5.0% (sensitivity 83%, specificity 100%, p < 0.01). The degree of overlap between PTV and bladder or rectum can be used to accurately guide physicians on the use of interventions to limit the extent of the overlap region prior to optimization.

  11. Peri-prostatic Fat Volume Measurement as a Predictive Tool for Castration Resistance in Advanced Prostate Cancer.

    Science.gov (United States)

    Salji, Mark; Hendry, Jane; Patel, Amit; Ahmad, Imran; Nixon, Colin; Leung, Hing Y

    2017-03-01

    Obesity and aggressive prostate cancer (PC) may be linked, but how local peri-prostatic fat relates to tumour response following androgen deprivation therapy (ADT) is unknown. To test if peri-prostatic fat volume (PPFV) predicts tumour response to ADT. We performed a retrospective study on consecutive patients receiving primary ADT. From staging pelvic magnetic resonance imaging scans, the PPFV was quantified with OsirixX 6.5 imaging software. Statistical (univariate and multivariate) analysis were performed using R Version 3.2.1. Of 224 consecutive patients, 61 with advanced (≥T3 or N1 or M1) disease had (3-mm high resolution axial sections) pelvic magnetic resonance imaging scan before ADT. Median age=75 yr; median PPFV=24.8cm(3) (range, 7.4-139.4cm(3)). PPFV was significantly higher in patients who developed castration resistant prostate cancer (CRPC; n=31), with a median of 37.9cm(3) compared with 16.1cm(3) (p <0.0001, Wilcoxon rank sum test) in patients who showed sustained response to ADT (n=30). Multivariate analysis using Cox proportional hazards models were performed controlling for known predictors of CRPC. PPFV was shown to be independent of all included factors, and the most significant predictor of time to CRPC. Using our multivariate model consisting of all known factors prior to ADT, PPFV significantly improved the area under the curve of the multivariate models receiver operating characteristic analysis. The main study limitation is a relatively small cohort to account for multiple variables, necessitating a future large-scale prospective analysis of PPFV in advanced PC. PPFV quantification in patients with advanced PC predicts tumour response to ADT. The amount of fat around the prostate predicts prostate cancer response to hormone treatment. Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  12. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (PME) (16th, Durham, NH, August 6-11, 1992). Volumes I-III.

    Science.gov (United States)

    Geeslin, William, Ed.; Graham, Karen, Ed.

    The Proceedings of PME-XVI has been published in three volumes because of the large number of papers presented at the conference. Volume 1 contains: (1) brief reports from each of the 11 standing Working Groups on their respective roles in organizing PME-XVI; (2) brief reports from 6 Discussion Groups; and (3) 35 research reports covering authors…

  13. Power Prediction and Technoeconomic Analysis of a Solar PV Power Plant by MLP-ABC and COMFAR III, considering Cloudy Weather Conditions

    Directory of Open Access Journals (Sweden)

    M. Khademi

    2016-01-01

    Full Text Available The prediction of power generated by photovoltaic (PV panels in different climates is of great importance. The aim of this paper is to predict the output power of a 3.2 kW PV power plant using the MLP-ABC (multilayer perceptron-artificial bee colony algorithm. Experimental data (ambient temperature, solar radiation, and relative humidity was gathered at five-minute intervals from Tehran University’s PV Power Plant from September 22nd, 2012, to January 14th, 2013. Following data validation, 10665 data sets, equivalent to 35 days, were used in the analysis. The output power was predicted using the MLP-ABC algorithm with the mean absolute percentage error (MAPE, the mean bias error (MBE, and correlation coefficient (R2, of 3.7, 3.1, and 94.7%, respectively. The optimized configuration of the network consisted of two hidden layers. The first layer had four neurons and the second had two neurons. A detailed economic analysis is also presented for sunny and cloudy weather conditions using COMFAR III software. A detailed cost analysis indicated that the total investment’s payback period would be 3.83 years in sunny periods and 4.08 years in cloudy periods. The results showed that the solar PV power plant is feasible from an economic point of view in both cloudy and sunny weather conditions.

  14. Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities (quotient testosterone/tumour volume

    Directory of Open Access Journals (Sweden)

    Antonio B. Porcaro

    2016-01-01

    Conclusion: The investigation shows that TT relates to volume and grade of PCa; moreover, the density of TT relative to TV inversely associates with rate of increase of cancer that depends on the grade of the tumour.

  15. Development and Application of Benchmark Examples for Mixed-Mode I/II Quasi-Static Delamination Propagation Predictions

    Science.gov (United States)

    Krueger, Ronald

    2012-01-01

    The development of benchmark examples for quasi-static delamination propagation prediction is presented. The example is based on a finite element model of the Mixed-Mode Bending (MMB) specimen for 50% mode II. The benchmarking is demonstrated for Abaqus/Standard, however, the example is independent of the analysis software used and allows the assessment of the automated delamination propagation prediction capability in commercial finite element codes based on the virtual crack closure technique (VCCT). First, a quasi-static benchmark example was created for the specimen. Second, starting from an initially straight front, the delamination was allowed to propagate under quasi-static loading. Third, the load-displacement as well as delamination length versus applied load/displacement relationships from a propagation analysis and the benchmark results were compared, and good agreement could be achieved by selecting the appropriate input parameters. The benchmarking procedure proved valuable by highlighting the issues associated with choosing the input parameters of the particular implementation. Overall, the results are encouraging, but further assessment for mixed-mode delamination fatigue onset and growth is required.

  16. Global fractional anisotropy and mean diffusivity together with segmented brain volumes assemble a predictive discriminant model for young and elderly healthy brains: a pilot study at 3T

    Science.gov (United States)

    Garcia-Lazaro, Haydee Guadalupe; Becerra-Laparra, Ivonne; Cortez-Conradis, David; Roldan-Valadez, Ernesto

    2016-01-01

    Summary Several parameters of brain integrity can be derived from diffusion tensor imaging. These include fractional anisotropy (FA) and mean diffusivity (MD). Combination of these variables using multivariate analysis might result in a predictive model able to detect the structural changes of human brain aging. Our aim was to discriminate between young and older healthy brains by combining structural and volumetric variables from brain MRI: FA, MD, and white matter (WM), gray matter (GM) and cerebrospinal fluid (CSF) volumes. This was a cross-sectional study in 21 young (mean age, 25.71±3.04 years; range, 21–34 years) and 10 elderly (mean age, 70.20±4.02 years; range, 66–80 years) healthy volunteers. Multivariate discriminant analysis, with age as the dependent variable and WM, GM and CSF volumes, global FA and MD, and gender as the independent variables, was used to assemble a predictive model. The resulting model was able to differentiate between young and older brains: Wilks’ λ = 0.235, χ2 (6) = 37.603, p = .000001. Only global FA, WM volume and CSF volume significantly discriminated between groups. The total accuracy was 93.5%; the sensitivity, specificity and positive and negative predictive values were 91.30%, 100%, 100% and 80%, respectively. Global FA, WM volume and CSF volume are parameters that, when combined, reliably discriminate between young and older brains. A decrease in FA is the strongest predictor of membership of the older brain group, followed by an increase in WM and CSF volumes. Brain assessment using a predictive model might allow the follow-up of selected cases that deviate from normal aging. PMID:27027893

  17. Changes in Theory-Based Psychological Factors Predict Weight Loss in Women with Class III Obesity Initiating Supported Exercise

    Science.gov (United States)

    Annesi, James J.; Gorjala, Srinivasa

    2010-01-01

    Background. Psychological factors' effect on weight loss is poorly understood, in general, and specifically in the severely obese. Objective. To examine whether a behavioral model based on tenets of social cognitive and self-efficacy theory will increase understanding of the relationship between exercise and weight loss. Methods. Fifty-one women with severe obesity participated in a 24-week exercise and nutrition information treatment and were measured on changes in psychological factors and exercise attendance. Results. A significant portion of the variance in BMI change (adjusted for number of predictors) was accounted for by the behavioral model (R2adj = 0.23). Entry of exercise session attendance only marginally improved the prediction to 0.27. Only 19% of the weight lost was directly attributable to caloric expenditure from exercise. Conclusions. Findings suggest that participation in an exercise program affects weight loss through psychological pathways and, thus, may be important in the behavioral treatment of severe obesity. PMID:20700411

  18. Changes in Theory-Based Psychological Factors Predict Weight Loss in Women with Class III Obesity Initiating Supported Exercise

    Directory of Open Access Journals (Sweden)

    James J. Annesi

    2010-01-01

    Full Text Available Background. Psychological factors' effect on weight loss is poorly understood, in general, and specifically in the severely obese. Objective. To examine whether a behavioral model based on tenets of social cognitive and self-efficacy theory will increase understanding of the relationship between exercise and weight loss. Methods. Fifty-one women with severe obesity participated in a 24-week exercise and nutrition information treatment and were measured on changes in psychological factors and exercise attendance. Results. A significant portion of the variance in BMI change (adjusted for number of predictors was accounted for by the behavioral model (2adj=0.23. Entry of exercise session attendance only marginally improved the prediction to 0.27. Only 19% of the weight lost was directly attributable to caloric expenditure from exercise. Conclusions. Findings suggest that participation in an exercise program affects weight loss through psychological pathways and, thus, may be important in the behavioral treatment of severe obesity.

  19. Analysis and Approach to the Development of an Advanced Multimedia Instructional System. Volume II. Appendix III. Media Cost Data. Final Report.

    Science.gov (United States)

    Rhode, William E.; And Others

    Basic cost estimates for selected instructional media are tabled in this document, Part II (Appendix III) of the report "Analysis and Approach to the Development of an Advanced Multimedia Instructional System" by William E. Rhode and others. Learning materials production costs are given for motion pictures, still visuals, videotapes, live…

  20. Nutrition and Health Characteristics of Low-Income Populations, Volume III, School-Age Children. E-FAN-04-014-3

    Science.gov (United States)

    Fox, Mary Kay; Cole, Nancy

    2004-01-01

    Data from the Third National Health and Nutrition Examination Survey (NHANES-III), conducted in 1988-94, were used to compare the nutrition and health characteristics of the Nation's school-age children--boys and girls ages 5-18. Three groups of children were compared based on household income: income at or below 130 percent of poverty (lowest…

  1. Risk scores to facilitate preoperative prediction of transfusion and large volume blood transfusion associated with adult cardiac surgery.

    Science.gov (United States)

    Goudie, R; Sterne, J A C; Verheyden, V; Bhabra, M; Ranucci, M; Murphy, G J

    2015-05-01

    The aim of this study was to develop two novel risk prediction scores for transfusion and bleeding that would be used to inform treatment decisions, quality assurance, and clinical trial design in cardiac surgery. Clinical data prospectively collected from 26 UK cardiac surgical centres and a single European centre were used to develop two risk prediction models: one for any red blood cell (RBC) transfusion, and the other for large volume blood transfusion (≥4 RBC units; LVBT), an index of severe blood loss. 'Complete case' data were available for 24 749 patients. Multiple imputation was used for missing covariate data (typically data set containing 39 970 patients. Risk models were developed in the complete case data set, with internal validation using leave-one-centre-out cross-validation. The final selected models were fitted to the imputed data set. Final risk scores were then compared with the performance of three existing scores: the Transfusion Risk and Clinical Knowledge score (TRACK), the Transfusion Risk Understanding Scoring Tool (TRUST), and the Papworth Bleeding Risk Score (BRiSc). The area under the receiver operating characteristic curve (AUC) was 0.77 (95% confidence interval 0.77-0.77) for the any RBC transfusion score and AUC 0.80 (0.79-0.80) for the LVBT score in the imputed data set. The LVBT model also showed excellent discrimination (Hosmer-Lemeshow P=0.32). In the imputed data set, the AUCs for the TRACK and TRUST scores for any RBC transfusion were 0.71 and 0.71, respectively, and for LVBT the AUC for the BRiSc score was 0.69. Two new risk scores for any RBC transfusion or LVBT among cardiac surgery patients have excellent discrimination, and could inform clinical decision making. © The Author 2015. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. Multiple Off-Ice Performance Variables Predict On-Ice Skating Performance in Male and Female Division III Ice Hockey Players.

    Science.gov (United States)

    Janot, Jeffrey M; Beltz, Nicholas M; Dalleck, Lance D

    2015-09-01

    The purpose of this study was to determine if off-ice performance variables could predict on-ice skating performance in Division III collegiate hockey players. Both men (n = 15) and women (n = 11) hockey players (age = 20.5 ± 1.4 years) participated in the study. The skating tests were agility cornering S-turn, 6.10 m acceleration, 44.80 m speed, modified repeat skate, and 15.20 m full speed. Off-ice variables assessed were years of playing experience, height, weight and percent body fat and off-ice performance variables included vertical jump (VJ), 40-yd dash (36.58m), 1-RM squat, pro-agility, Wingate peak power and peak power percentage drop (% drop), and 1.5 mile (2.4km) run. Results indicated that 40-yd dash (36.58m), VJ, 1.5 mile (2.4km) run, and % drop were significant predictors of skating performance for repeat skate (slowest, fastest, and average time) and 44.80 m speed time, respectively. Four predictive equations were derived from multiple regression analyses: 1) slowest repeat skate time = 2.362 + (1.68 x 40-yd dash time) + (0.005 x 1.5 mile run), 2) fastest repeat skate time = 9.762 - (0.089 x VJ) - (0.998 x 40-yd dash time), 3) average repeat skate time = 7.770 + (1.041 x 40-yd dash time) - (0.63 x VJ) + (0.003 x 1.5 mile time), and 4) 47.85 m speed test = 7.707 - (0.050 x VJ) - (0.01 x % drop). It was concluded that selected off-ice tests could be used to predict on-ice performance regarding speed and recovery ability in Division III male and female hockey players. Key pointsThe 40-yd dash (36.58m) and vertical jump tests are significant predictors of on-ice skating performance specific to speed.In addition to 40-yd dash and vertical jump, the 1.5 mile (2.4km) run for time and percent power drop from the Wingate anaerobic power test were also significant predictors of skating performance that incorporates the aspect of recovery from skating activity.Due to the specificity of selected off-ice variables as predictors of on-ice performance, coaches can

  3. Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia

    Energy Technology Data Exchange (ETDEWEB)

    Belli, Maria Luisa; Broggi, Sara [Ospedale San Raffaele Scientific Institute, Medical Physics, Milano (Italy); Scalco, Elisa; Rizzo, Giovanna [CNR, Istituto di Bioimmagini e Fisiologia Molecolare, Milano (Italy); Sanguineti, Giuseppe [Regina Elena National Cancer Institute, Department of Radiation Oncology, Rome (Italy); Fiorino, Claudio; Cattaneo, Giovanni Mauro [Ospedale San Raffaele Scientific Institute, Medical Physics, Milano (Italy); CNR, Istituto di Bioimmagini e Fisiologia Molecolare, Milano (Italy); Dinapoli, Nicola; Valentini, Vincenzo [Universita Cattolica del Sacro Cuore, Radiotherapy, Rome (Italy); Ricchetti, Francesco [Ospedale Sacro Cuore, Radiotherapy, Negrar (Italy)

    2014-11-15

    To quantitatively assess the predictive power of early variations of parotid gland volume and density on final changes at the end of therapy and, possibly, on acute xerostomia during IMRT for head-neck cancer. Data of 92 parotids (46 patients) were available. Kinetics of the changes during treatment were described by the daily rate of density (rΔρ) and volume (rΔvol) variation based on weekly diagnostic kVCT images. Correlation between early and final changes was investigated as well as the correlation with prospective toxicity data (CTCAEv3.0) collected weekly during treatment for 24/46 patients. A higher rΔρ was observed during the first compared to last week of treatment (-0,50 vs -0,05HU, p-value = 0.0001). Based on early variations, a good estimation of the final changes may be obtained (Δρ: AUC = 0.82, p = 0.0001; Δvol: AUC = 0.77, p = 0.0001). Both early rΔρ and rΔvol predict a higher ''mean'' acute xerostomia score (≥ median value, 1.57; p-value = 0.01). Median early density rate changes for patients with mean xerostomia score ≥ / < 1.57 were -0.98 vs -0.22 HU/day respectively (p = 0.05). Early density and volume variations accurately predict final changes of parotid glands. A higher longitudinally assessed score of acute xerostomia is well predicted by higher rΔρ and rΔvol in the first two weeks of treatment: best cut-off values were -0.50 HU/day and -380 mm{sup 3}/day for rΔρ and rΔvol respectively. Further studies are necessary to definitively assess the potential of early density/volume changes in identifying more sensitive patients at higher risk of experiencing xerostomia. (orig.) [German] Ziel der Studie ist die Untersuchung der praediktiven Aussagekraft von fruehen Veraenderungen in Volumen und Dichte der Ohrspeicheldruese in Bezug auf die finale Verformung zum Ende der Therapie sowie das Risiko von Xerostomie waehrend der intesitaetsmodulierten Strahlentherapie (IMRT) bei Kopf und Hals Tumoren. Die Studie

  4. Method of tumor volume evaluation using magnetic resonance imaging for outcome prediction in cervical cancer treated with concurrent chemotherapy and radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hun Jung; Kim, Woo Chul [Inha University Hospital, Inha University School of Medicine, Seoul (Korea, Republic of)

    2012-06-15

    To evaluate the patterns of tumor shape and to compare tumor volume derived from simple diameter-based ellipsoid measurement with that derived from tracing the entire tumor contour using region of interest (ROI)-based 3D volumetry with respect to the prediction outcome in cervical cancer patients treated with concurrent chemotherapy and radiotherapy. Magnetic resonance imaging was performed in 98 patients with cervical cancer (stage IB-IIIB). The tumor shape was classified into two categories: ellipsoid and non-ellipsoid shape. ROI-based volumetry was derived from each magnetic resonance slice on the work station. For the diameter-based surrogate 'ellipsoid volume,' the three orthogonal diameters were measured to calculate volume as an ellipsoid. The more than half of tumor (55.1%) had a non-ellipsoid configuration. The predictions for outcome were consistent between two volume groups, with overall survival of 93.6% and 87.7% for small tumor (<20 mL), 62.9% and 69.1% for intermediate-size tumor (20-39 mL), and 14.5% and 16.7% for large tumors ({>=}40 mL) using ROI and diameter based measurement, respectively. Disease-free survival was 93.8% and 90.6% for small tumor, 54.3% and 62.7% for intermediate-size tumor, and 13.7% and 10.3% for large tumor using ROI and diameter based method, respectively. Differences in outcome between size groups were statistically significant, and the differences in outcome predicted by the tumor volume by two different methods. Our data suggested that large numbers of cervical cancers are not ellipsoid. However, simple diameter-based tumor volume measurement appears to be useful in comparison with ROI-based volumetry for predicting outcome in cervical cancer patients.

  5. Energy use in the marine transportation industry: Task III. Efficiency improvements; Task IV. Industry future. Final report, Volume IV. [Projections for year 2000

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-12-01

    Tasks III and IV measure the characteristics of potential research and development programs that could be applied to the maritime industry. It was necessary to identify potential operating scenarios for the maritime industry in the year 2000 and determine the energy consumption that would result given those scenarios. After the introductory chapter the operational, regulatory, and vessel-size scenarios for the year 2000 are developed in Chapter II. In Chapter III, future cargo flows and expected levels of energy use for the baseline 2000 projection are determined. In Chapter IV, the research and development programs are introduced into the future US flag fleet and the energy-savings potential associated with each is determined. The first four appendices (A through D) describe each of the generic technologies. The fifth appendix (E) contains the baseline operating and cost parameters against which 15 program areas were evaluated. (MCW)

  6. Computer-Based Testing System. Project STEEL. A Special Project To Develop and Implement a Computer-Based Special Teacher Education and Evaluation Laboratory. Volume III. Final Report.

    Science.gov (United States)

    Frick, Theodore W.; And Others

    The document is part of the final report on Project STEEL (Special Teacher Education and Evaluation Laboratory) intended to extend the utilization of technology in the training of preservice special education teachers. This volume focuses on the third of four project objectives, the development and implementation of a computer-based testing…

  7. Study of Manpower Requirements by Occupation for Alternative Technologies in the Energy-Related Industries, 1970-1990. Volumes I, IIA, and III.

    Science.gov (United States)

    Gutmanis, Ivars; And Others

    The report presents the methodology used by the National Planning Association (NPA), under contract to the Federal Energy Administration (FEA), to estimate direct labor usage coefficients in some sixty different occupational categories involved in construction, operation, and maintenance of energy facilities. Volume 1 presents direct labor usage…

  8. Predictive value of PET response combined with baseline metabolic tumor volume in peripheral T-cell lymphoma patients.

    Science.gov (United States)

    Cottereau, Anne-Segolene; El-Galaly, Tarec C; Becker, Stéphanie; Broussais, Florence; Peterson, Lars Jelstrup; Bonnet, Christophe; Prior, John O; Tilly, Herve; Hutchings, Martin; Casasnovas, Olivier; Meignan, Michel A

    2017-09-01

    Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of aggressive non-Hodgkin lymphomas with poor outcomes with current therapy. We investigated if response assessed with Positron Emission Tomography/computed tomography (PET/CT) combined with baseline total metabolic tumor volume (TMTV) could detect early relapse/refractory patients. Methods: 140 patients with nodal PTCL who underwent baseline PET/CT were selected from 7 European centers. 43 had interim PET (iPET) performed after two cycles (iPET2), 95 after 3 or 4 cycles (iPET3/4) and 96 had end of treatment PET (eotPET). Baseline TMTV was computed with 41% SUVmax threshold, and PET response was reported with the Deauville 5-point scale (5-PS). Results: With 43 months median follow-up, the 2-year Progression free survival (PFS) and Overall survival (OS) were 51% and 67%. Positive iPET2 patients (5-PS ≥4) had a significantly worse outcome than those with negative iPET2 (p230cm(3) and iPET3/4 negative (59%/84%); TMTV≤230cm(3) and iPET3/4 positive (42%/50%); TMTV>230cm(3) and iPET3/4 positive (0%/18%). Conclusion: IPET response is predictive of outcome and allows early detection of high-risk PTCL patients. Combining iPET with TMTV improves risk stratification in individual patients. Copyright © 2017 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

  9. Prognostic prediction across a gradient of total tumor volume in patients with hepatocellular carcinoma undergoing locoregional therapy

    Directory of Open Access Journals (Sweden)

    Lin Han C

    2010-12-01

    Full Text Available Abstract Background The size and number of tumors are important prognostic indicators for hepatocellular carcinoma (HCC. However, it is difficult to assess the prognosis for patients with a variable number and size of tumors. By combining these two factors, we investigated the role and prognostic accuracy of total tumor volume (TTV for HCC. Methods A total of 786 patients undergoing locoregional therapy (transarterial chemoembolization, percutaneous radiofrequency ablation and acetic acid or ethanol injection for HCC were prospectively evaluated. Results The mean and median TTV was 177 cm3 (range, 0.1-3,591 cm3 and 21 cm3, respectively. Of all, 38%, 29%, 15%, 7% and 11% of patients had TTV of 3, 10-50 cm3, 50-200 cm3, 200-500 cm3 and >500 cm3, respectively. TTV was significantly larger in patients with higher serum α-fetoprotein (AFP levels or with vascular invasion. The Child-Turcotte-Pugh score, performance status, vascular invasion, AFP level and TTV were significant independent prognostic predictors in the Cox proportional hazards model. After adjustment, patients with TTV 50-200 cm3 (relative risk [RR]: 1.74, p = 0.009, 200-500 cm3 (RR: 2.15, p = 0.006 and >500 cm3 (RR: 3.92, p 3. Conclusions TTV is a feasible prognostic predictor across a wide gradient and can be used to predict the mortality risk of HCC. Selecting appropriate cutoffs of TTV may help refine the design of cancer staging system and treatment planning. Future clinical trials of HCC may include this parameter for mortality risk stratification.

  10. Three-dimensional changes of the hyoid bone and airway volumes related to its relationship with horizontal anatomic planes after bimaxillary surgery in skeletal Class III patients.

    Science.gov (United States)

    Kim, Min-Ah; Kim, Bo-Ram; Choi, Jin-Young; Youn, Jong-Kuk; Kim, Yoon-Ji R; Park, Yang-Ho

    2013-07-01

    To evaluate longitudinal changes of the hyoid bone position and pharyngeal airway space after bimaxillary surgery in mandibular prognathism patients. Cone-beam computed tomography scans were taken for 25 mandibular prognathism patients before surgery (T0), 2 months after surgery (T1), and 6 months after surgery (T2). The positional displacement of the hyoid bone was assessed using the coordinates at T0, T1, and T2. Additionally, the volume of each subject's pharyngeal airway was measured. The mean amount of posterior maxilla impaction was 3.76 ± 1.33 mm as the palatal plane rotated 2.04° ± 2.28° in a clockwise direction as a result of bimaxillary surgery. The hyoid bone moved backward (P .05, P bimaxillary surgery. The decrease in the pharyngeal airway volume was correlated to the changes in the palatal plane inclination and the positional change of the hyoid bone.

  11. Central Receiver Solar Thermal Power System, Phase 1. CDRL Item 2. Pilot Plant preliminary design report. Volume III, Book 1. Collector subsystem

    Energy Technology Data Exchange (ETDEWEB)

    Hallet, Jr., R. W.; Gervais, R. L.

    1977-10-01

    The central receiver system consists of a field of heliostats, a central receiver, a thermal storage unit, an electrical power generation system, and balance of plant. This volume discusses the collector field geometry, requirements and configuration. The development of the collector system and subsystems are discussed and the selection rationale outlined. System safety and availability are covered. Finally, the plans for collector portion of the central receiver system are reviewed.

  12. Line-focus solar central power system, Phase I. Final report, 29 September 1978 to 30 April 1980. Volume III. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Slemmons, A J

    1980-04-01

    The conceptual design, parametric analysis, cost and performance analysis, and commercial assessment of a 100-MWe line-focus solar central receiver power plant are reported. This volume contains the appendices: (a) methods of determination of molten salt heat-transfer coefficients and tube-wall temperatures, (b) inputs for STEAEC programs, (c) description of system analysis computer program, (d) receiver analysis program, and (e) heliostat production plan and design methodology. (WHK)

  13. An EGARCH-BPNN system for estimating and predicting stock market volatility in Morocco and Saudi Arabia: The effect of trading volume

    Directory of Open Access Journals (Sweden)

    Salim Lahmiri

    2012-08-01

    Full Text Available In this study, the backpropagation neural network (BPNN is tested for the ability to forecast the daily volatility of two stock market indices from the Middle East and North Africa (MENA region using volume; namely Morocco and Saudi Arabia. Volatility series were estimated using the Exponential Auto-Regressive Conditional Heteroskedasticity (EGARCH model. The simulation results show that trading volume helps improving the forecasting accuracy of BPNN in Morocco but not in Saudi Arabia. As a result, volume represents valuable information flow to be used in the modeling and prediction of volatility in Morocco. In addition, it is found that BPNN overpredicts volatility during high volatile periods. This finding is important in financial applications such as asset allocation and derivatives pricing.

  14. The accurate definition of metabolic volumes on {sup 18}F-FDG-PET before treatment allows the response to chemoradiotherapy to be predicted in the case of oesophagus cancers; La definition precise des volumes metaboliques sur TEP au 18F-FDG avant traitement permet la prediction de la reponse a la chimioradiotherapie dans les cancers de l'oesophage

    Energy Technology Data Exchange (ETDEWEB)

    Hatt, M.; Cheze-Le Rest, C.; Visvikis, D. [Inserm U650, Brest (France); Pradier, O. [Radiotherapie, CHRU Morvan, Brest (France)

    2011-10-15

    This study aims at assessing the possibility of prediction of the response of locally advanced oesophagus cancers, even before the beginning of treatment, by using metabolic volume measurements performed on {sup 18}F-FDG PET images made before the treatment. Medical files of 50 patients have been analyzed. According to the observed responses, and to metabolic volume and Total Lesion Glycosis (TLG) values, it appears that the images allow the extraction of parameters, such as the TLG, which are criteria for the prediction of the therapeutic response. Short communication

  15. Chest wall volume receiving >30 Gy predicts risk of severe pain and/or rib fracture after lung stereotactic body radiotherapy.

    Science.gov (United States)

    Dunlap, Neal E; Cai, Jing; Biedermann, Gregory B; Yang, Wensha; Benedict, Stanley H; Sheng, Ke; Schefter, Tracey E; Kavanagh, Brian D; Larner, James M

    2010-03-01

    To identify the dose-volume parameters that predict the risk of chest wall (CW) pain and/or rib fracture after lung stereotactic body radiotherapy. From a combined, larger multi-institution experience, 60 consecutive patients treated with three to five fractions of stereotactic body radiotherapy for primary or metastatic peripheral lung lesions were reviewed. CW pain was assessed using the Common Toxicity Criteria for pain. Peripheral lung lesions were defined as those located within 2.5 cm of the CW. A minimal point dose of 20 Gy to the CW was required. The CW volume receiving >or=20, >or=30, >or=40, >or=50, and >or=60 Gy was determined and related to the risk of CW toxicity. Of the 60 patients, 17 experienced Grade 3 CW pain and five rib fractures. The median interval to the onset of severe pain and/or fracture was 7.1 months. The risk of CW toxicity was fitted to the median effective concentration dose-response model. The CW volume receiving 30 Gy best predicted the risk of severe CW pain and/or rib fracture (R(2) = 0.9552). A volume threshold of 30 cm(3) was observed before severe pain and/or rib fracture was reported. A 30% risk of developing severe CW toxicity correlated with a CW volume of 35 cm(3) receiving 30 Gy. The development of CW toxicity is clinically relevant, and the CW should be considered an organ at risk in treatment planning. The CW volume receiving 30 Gy in three to five fractions should be limited to <30 cm(3), if possible, to reduce the risk of toxicity without compromising tumor coverage. Copyright (c) 2010 Elsevier Inc. All rights reserved.

  16. Critical combinations of radiation dose and volume predict intelligence quotient and academic achievement scores after craniospinal irradiation in children with medulloblastoma.

    Science.gov (United States)

    Merchant, Thomas E; Schreiber, Jane E; Wu, Shengjie; Lukose, Renin; Xiong, Xiaoping; Gajjar, Amar

    2014-11-01

    To prospectively follow children treated with craniospinal irradiation to determine critical combinations of radiation dose and volume that would predict for cognitive effects. Between 1996 and 2003, 58 patients (median age 8.14 years, range 3.99-20.11 years) with medulloblastoma received risk-adapted craniospinal irradiation followed by dose-intense chemotherapy and were followed longitudinally with multiple cognitive evaluations (through 5 years after treatment) that included intelligence quotient (estimated intelligence quotient, full-scale, verbal, and performance) and academic achievement (math, reading, spelling) tests. Craniospinal irradiation consisted of 23.4 Gy for average-risk patients (nonmetastatic) and 36-39.6 Gy for high-risk patients (metastatic or residual disease >1.5 cm(2)). The primary site was treated using conformal or intensity modulated radiation therapy using a 2-cm clinical target volume margin. The effect of clinical variables and radiation dose to different brain volumes were modeled to estimate cognitive scores after treatment. A decline with time for all test scores was observed for the entire cohort. Sex, race, and cerebrospinal fluid shunt status had a significant impact on baseline scores. Age and mean radiation dose to specific brain volumes, including the temporal lobes and hippocampi, had a significant impact on longitudinal scores. Dichotomized dose distributions at 25 Gy, 35 Gy, 45 Gy, and 55 Gy were modeled to show the impact of the high-dose volume on longitudinal test scores. The 50% risk of a below-normal cognitive test score was calculated according to mean dose and dose intervals between 25 Gy and 55 Gy at 10-Gy increments according to brain volume and age. The ability to predict cognitive outcomes in children with medulloblastoma using dose-effects models for different brain subvolumes will improve treatment planning, guide intervention, and help estimate the value of newer methods of irradiation. Copyright © 2014

  17. III-V microelectronics

    CERN Document Server

    Nougier, JP

    1991-01-01

    As is well known, Silicon widely dominates the market of semiconductor devices and circuits, and in particular is well suited for Ultra Large Scale Integration processes. However, a number of III-V compound semiconductor devices and circuits have recently been built, and the contributions in this volume are devoted to those types of materials, which offer a number of interesting properties. Taking into account the great variety of problems encountered and of their mutual correlations when fabricating a circuit or even a device, most of the aspects of III-V microelectronics, from fundamental p

  18. Variations in target volume definition for postoperative radiotherapy in stage III non-small-cell lung cancer: analysis of an international contouring study.

    Science.gov (United States)

    Spoelstra, Femke O B; Senan, Suresh; Le Péchoux, Cecile; Ishikura, Satoshi; Casas, Francesc; Ball, David; Price, Allan; De Ruysscher, Dirk; van Sörnsen de Koste, John R

    2010-03-15

    Postoperative radiotherapy (PORT) in patients with completely resected non-small-cell lung cancer with mediastinal involvement is controversial because of the failure of earlier trials to demonstrate a survival benefit. Improved techniques may reduce toxicity, but the treatment fields used in routine practice have not been well studied. We studied routine target volumes used by international experts and evaluated the impact of a contouring protocol developed for a new prospective study, the Lung Adjuvant Radiotherapy Trial (Lung ART). Seventeen thoracic radiation oncologists were invited to contour their routine clinical target volumes (CTV) for 2 representative patients using a validated CD-ROM-based contouring program. Subsequently, the Lung ART study protocol was provided, and both cases were contoured again. Variations in target volumes and their dosimetric impact were analyzed. Routine CTVs were received for each case from 10 clinicians, whereas six provided both routine and protocol CTVs for each case. Routine CTVs varied up to threefold between clinicians, but use of the Lung ART protocol significantly decreased variations. Routine CTVs in a postlobectomy patient resulted in V(20) values ranging from 12.7% to 54.0%, and Lung ART protocol CTVs resulted in values of 20.6% to 29.2%. Similar results were seen for other toxicity parameters and in the postpneumectomy patient. With the exception of upper paratracheal nodes, protocol contouring improved coverage of the required nodal stations. Even among experts, significant interclinician variations are observed in PORT fields. Inasmuch as contouring variations can confound the interpretation of PORT results, mandatory quality assurance procedures have been incorporated into the current Lung ART study. Copyright 2010 Elsevier Inc. All rights reserved.

  19. A hybrid mixture discriminant analysis-random forest computational model for the prediction of volume of distribution of drugs in human.

    Science.gov (United States)

    Lombardo, Franco; Obach, R Scott; Dicapua, Frank M; Bakken, Gregory A; Lu, Jing; Potter, David M; Gao, Feng; Miller, Michael D; Zhang, Yao

    2006-04-06

    A computational approach is described that can predict the VD(ss) of new compounds in humans, with an accuracy of within 2-fold of the actual value. A dataset of VD values for 384 drugs in humans was used to train a hybrid mixture discriminant analysis-random forest (MDA-RF) model using 31 computed descriptors. Descriptors included terms describing lipophilicity, ionization, molecular volume, and various molecular fragments. For a test set of 23 proprietary compounds not used in model construction, the geometric mean fold-error (GMFE) was 1.78-fold (+/-11.4%). The model was also tested using a leave-class out approach wherein subsets of drugs based on therapeutic class were removed from the training set of 384, the model was recast, and the VD(ss) values for each of the subsets were predicted. GMFE values ranged from 1.46 to 2.94-fold, depending on the subset. Finally, for an additional set of 74 compounds, VD(ss) predictions made using the computational model were compared to predictions made using previously described methods dependent on animal pharmacokinetic data. Computational VD(ss) predictions were, on average, 2.13-fold different from the VD(ss) predictions from animal data. The computational model described can predict human VD(ss) with an accuracy comparable to predictions requiring substantially greater effort and can be applied in place of animal experimentation.

  20. Evaluation of the Synthoil process. Volume III. Unit block flow diagrams for a 100,000 barrel/stream day facility

    Energy Technology Data Exchange (ETDEWEB)

    Salmon, R.; Edwards, M.S.; Ulrich, W.C.

    1977-06-01

    This volume consists of individual block flowsheets for the various units of the Synthoil facility, showing the overall flows into and out of each unit. Material balances for the following units are incomplete because these are proprietary processes and the information was not provided by the respective vendors: Unit 24-Claus Sulfur Plant; Unit 25-Oxygen Plant; Unit 27-Sulfur Plant (Redox Type); and Unit 28-Sour Water Stripper and Ammonia Recovery Plant. The process information in this form was specifically requested by ERDA/FE for inclusion in the final report.

  1. Prediction of subacute infarct lesion volumes by processing apparent diffusion coefficient maps based on apparent diffusion coefficient cut-off values in patients with acute stroke

    Institute of Scientific and Technical Information of China (English)

    郭翔

    2014-01-01

    Objective To explore the feasibility of prediction of subacute infarct lesion volumes by processing ADC maps based on ADC cut-off values in patients with acute stroke.Methods MRI was performed in 20 patients with clinically diagnosed acute infarct less than 6 h after stroke onset.The MRI included a DWI and conventional MRI.The follow-up MR examinations of all the patients

  2. High Ki-67 and Vascular Endothelial Growth Factor (VEGF Protein Expression as Negative Predictive Factor for Combined Neoadjuvant Chemotherapy in Young Age Stage III Breast Cancer

    Directory of Open Access Journals (Sweden)

    I Wayan Sudarsa

    2016-05-01

    Full Text Available Background: Breast cancer was, in general, a heterogeneous disease with diverse biological characteristics, types, subtypes and clinical behavior. Its treatment and management need to be personalized and individualized. Breast cancer in young ages, although rare, is usually a unique and more aggressive cancer associated with poorer prognosis. The combination of young age and advanced stages of breast cancer would make this particular breast cancer harder to treat and cure. Unfortunately, majority of Breast Cancer Patients in Bali were in younger ages, and at advanced stages, that the mainstay of treatment was neo-adjuvant chemotherapy followed by other treatment modalities. Improve prognosis only, those patients who had had a complete pathological response involving primary tumor and regional lymph nodes in the axilla. Several factors had been studied and contributed to breast cancer response to combined neo-adjuvant chemotherapy. Usually, younger patients, was associated with high proliferation rate represented by Ki-67 and early distant metastasis represented by VEGF, which also had role as prognostic markers. The purpose of this study was to determine whether high Ki-67 and VEGF expression correlate with response to NAC and hence, they would be important predictive factors for response to NAC. Method: This study was a cross-sectional and a nested case-control study of stage III breast cancers affecting patients 40 years of age or less, at Sanglah General Hospital and Prima Medika Hospital, conducted from September 1st, 2012 until March 31st, 2014. Clinical and pathology reports were traced and recorded from both hospitals; routine Immunohistochemistry (IHC examinations were performed by both pathology labs. Statistical analysis was performed using Chi-Square test, Odds Ratio (OR, and logistic regression analysis with p<0.05. Results: There were 66 Stage III young breast cancer patients, where 35 (53% showed no or negative response and 31 (47

  3. Density and molar volumes of imidazolium-based ionic liquid mixtures and prediction by the Jouyban-Acree model

    Science.gov (United States)

    Ghani, Noraini Abd; Sairi, Nor Asrina; Mat, Ahmad Nazeer Che; Khoubnasabjafari, Mehry; Jouyban, Abolghasem

    2016-11-01

    The density of imidazolium-based ionic liquid, 1-ethyl-3-methylimidazolium diethylphosphate with sulfolane were measured at atmospheric pressure. The experiments were performed at T= (293 - 343) K over the complete mole fractions. Physical and thermodynamic properties such as molar volumes, V0, and excess molar volumes, VE for this binary mixtures were derived from the experimental density data. The Jouyban-Acree model was exploited to correlate the physicochemical properties (PCPs) of binary mixtures at various mole fractions and temperatures.

  4. Reionization on Large Scales III: Predictions for Low-ell Cosmic Microwave Background Polarization and High-ell Kinetic Sunyaev-Zel'dovich Observables

    CERN Document Server

    Battaglia, Nick; Trac, Hy; Cen, Renyue; Loeb, Abraham

    2012-01-01

    We present new predictions for temperature (on small angular scales) and polarization (on large angular scales) CMB anisotropies induced during the epoch of reionization (EoR). Using a novel method calibrated from Radiation-Hydrodynamic simulations we model the EoR in large volumes (L >~ 2 Gpc/h) in the context of galactic reionization. We find that the EoR contribution to the kinetic Sunyaev- Zel'dovich power spectrum (patchy kSZ) ranges between ~0.6 - 2.8 muK^2 at ell = 3000, for the parameter space we explored. These patchy kSZ power spectra are calculated from large 15 Deg x 15 Deg maps that are found to be necessary. Decreasing the size of these maps biases the overall patchy kSZ power to higher values. We find that the amplitude of the patchy kSZ power spectrum at ell = 3000 follows simple scalings of D_ell=3000^kSZ propto and D_ell=3000^kSZ propto Delz^0.47 for the mean redshift () of reionization and the duration (dz). Using the constraints on from WMAP 7-year results and the lower limit on dz from ...

  5. T346Hunter: a novel web-based tool for the prediction of type III, type IV and type VI secretion systems in bacterial genomes.

    Directory of Open Access Journals (Sweden)

    Pedro Manuel Martínez-García

    Full Text Available T346Hunter (Type Three, Four and Six secretion system Hunter is a web-based tool for the identification and localisation of type III, type IV and type VI secretion systems (T3SS, T4SS and T6SS, respectively clusters in bacterial genomes. Non-flagellar T3SS (NF-T3SS and T6SS are complex molecular machines that deliver effector proteins from bacterial cells into the environment or into other eukaryotic or prokaryotic cells, with significant implications for pathogenesis of the strains encoding them. Meanwhile, T4SS is a more functionally diverse system, which is involved in not only effector translocation but also conjugation and DNA uptake/release. Development of control strategies against bacterial-mediated diseases requires genomic identification of the virulence arsenal of pathogenic bacteria, with T3SS, T4SS and T6SS being major determinants in this regard. Therefore, computational methods for systematic identification of these specialised machines are of particular interest. With the aim of facilitating this task, T346Hunter provides a user-friendly web-based tool for the prediction of T3SS, T4SS and T6SS clusters in newly sequenced bacterial genomes. After inspection of the available scientific literature, we constructed a database of hidden Markov model (HMM protein profiles and sequences representing the various components of T3SS, T4SS and T6SS. T346Hunter performs searches of such a database against user-supplied bacterial sequences and localises enriched regions in any of these three types of secretion systems. Moreover, through the T346Hunter server, users can visualise the predicted clusters obtained for approximately 1700 bacterial chromosomes and plasmids. T346Hunter offers great help to researchers in advancing their understanding of the biological mechanisms in which these sophisticated molecular machines are involved. T346Hunter is freely available at http://bacterial-virulence-factors.cbgp.upm.es/T346Hunter.

  6. New Concepts in Fish Ladder Design, Volume III of IV, Assessment of Fishway Development and Design, 1982-1983 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Powers, Patrick D.; Orsborn, John F.

    1985-08-01

    This volume covers the broad, though relatively short, historical basis for this project. The historical developments of certain design features, criteria and research activities are traced. Current design practices are summarized based on the results of an international survey and interviews with agency personnel and consultants. The fluid mechanics and hydraulics of fishway systems are discussed. Fishways (or fishpasses) can be classified in two ways: (1) on the basis of the method of water control (chutes, steps (ladders), or slots); and (2) on the basis of the degree and type of water control. This degree of control ranges from a natural waterfall to a totally artificial environment at a hatchery. Systematic procedures for analyzing fishways based on their configuration, species, and hydraulics are presented. Discussions of fish capabilities, energy expenditure, attraction flow, stress and other factors are included.

  7. Applied research on energy storage and conversion for photovoltaic and wind energy systems. Volume III. Wind conversion systems with energy storage. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-01

    The variability of energy output inherent in wind energy conversion systems (WECS) has led to the investigation of energy storage as a means of managing the available energy when immediate, direct use is not possible or desirable. This portion of the General Electric study was directed at an evaluation of those energy storage technologies deemed best suited for use in conjunction with a wind energy conversion system in utility, residential and intermediate applications. Break-even cost goals are developed for several storage technologies in each application. These break-even costs are then compared with cost projections presented in Volume I of this report to show technologies and time frames of potential economic viability. The report summarizes the investigations performed and presents the results, conclusions and recommendations pertaining to use of energy storage with wind energy conversion systems.

  8. Sweet Lake geopressured-geothermal project, Magma Gulf-Technadril/DOE Amoco fee. Volume III. Final report. Annual report, February 1982-March 1985

    Energy Technology Data Exchange (ETDEWEB)

    Durham, C.O. Jr.; O' Brien, F.D.; Rodgers, R.W. (eds.)

    1985-01-01

    This report presents the results of the testing of Sand 3 (15,245 to 15,280 feet in depth) which occurred from November 1983 to March 1984 and evaluates these new data in comparison to results from the testing of Sand 5 (15,385 to 15,415 feet in depth) which occurred from June 1981 to February 1982. It also describes the reworking of the production and salt water disposal wells preparatory to the Sand 3 testing as well as the plug and abandon procedures requested to terminate the project. The volume contains two parts: Part 1 includes the text and accompanying plates, figures and tables; Part 2 consists of the appendixes including auxiliary reports and tabulations.

  9. Developing Successful Proposals in Women's Educational Equity, Volume I: The Guide = Desarrollo de propuestas exitosas relacionadas con la equidad educativa de la mujer, volumen I: La guia. Volume II: The Supplement. Volume III: The Swipe File. Volume IV: Workshop Training Manual.

    Science.gov (United States)

    Matthews, Walter R.; And Others

    Four volumes present materials and a training workshop on proposal writing. The materials aim to give people the skills and resources with which to translate their ideas into fully developed grant proposals for projects related to educational equity for women. However, the information is applicable to most other funding procedures. The first…

  10. Volume-based predictive biomarkers of sequential FDG-PET/CT for sunitinib in cancer of unknown primary: identification of the best benefited patients

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Yifei [Second Military Medical University, Department of Orthorpedic Oncology, Changzheng Hospital, Shanghai (China); Second Military Medical University, Department of Pathology, Changzheng Hospital, Shanghai (China); Xu, Wei; Xiao, Jianru [Second Military Medical University, Department of Orthorpedic Oncology, Changzheng Hospital, Shanghai (China); Bai, Ruojing [Geriatrics Institute, Department of Geriatrics, Tianjin Medical University General Hospital, Laboratory of Neuro-Trauma and Neurodegenerative Disorder, Tianjin (China); Li, Yiming [Neurosurgery Institute, Department of Neuro-oncology, Beijing (China); Yu, Hongyu [Second Military Medical University, Department of Pathology, Changzheng Hospital, Shanghai (China); Yang, Chunshan [Panorama Medical Imaging Center, Department of PET/CT Radiology, Shanghai (China); Department of PET/CT Radiology Center, Shanghai (China); Shi, Huazheng; Zhang, Jian [Department of PET/CT Radiology Center, Shanghai (China); Li, Jidong [The First People' s Hospital of Shangqiu, Department of Stomatology, Shangqiu, Henan Province (China); Wang, Chenguang [Second Military Medical University, Department of Radiology, Changzheng Hospital, Shanghai (China)

    2017-02-15

    To test the performance of sequential {sup 18}F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in predicting survival after sunitinib therapies in patients with cancer of unknown primary (CUP). CUP patients were enrolled for sequential PET/CT scanning for sunitinib and a control group. Univariate and multivariate analysis were applied to test the efficacy of sunitinib therapy in CUP patients. Next, sequential analyses involving PET/CT parameters were performed to identify and validate sensitive PET/CT biomarkers for sunitinib therapy. Finally, time-dependent receiver operating characteristic (TDROC) analyses were performed to compare the predictive accuracy. Multivariate analysis proved that sunitinib group had significantly improved survival (p < 0.01) as compared to control group. After cycle 2 of therapy, multivariate analysis identified volume-based PET/CT parameters as sensitive biomarkers for sunitinib (p < 0.01). TDROC curves demonstrated whole-body total lesion glycolysis reduction (Δ WTLG) and follow-up WTLG to have good accuracy for efficacy prediction. This evidence was validated after cycle 4 of therapy with the same method. Sunitinib therapy proved effective in treatment of CUP. PET/CT volume-based parameters may help predict outcome of sunitinib therapy, in which Δ WTLG and follow-up WTLG seem to be sensitive biomarkers for sunitinib efficacy. Patients with greater reduction and lower WTLG at follow-up seem to have better survival outcome. (orig.)

  11. SU-E-T-170: Characterization of the Location, Extent, and Proximity to Critical Structures of Target Volumes Provides Detail for Improved Outcome Predictions Among Pancreatic Cancer Patients

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Z; Moore, J; Rosati, L; Mian, O; Narang, A; Herman, J; McNutt, T [Johns Hopkins University, Baltimore, MD (United States)

    2015-06-15

    Purpose: In radiotherapy, size, location and proximity of the target to critical structures influence treatment decisions. It has been shown that proximity of the target predicts dosimetric sparing of critical structures. In addition to dosimetry, precise location of disease has further implications such as tumor invasion, or proximity to major arteries that inhibit surgery. Knowledge of which patients can be converted to surgical candidates by radiation may have high impact on future treat/no-treat decisions. We propose a method to improve our characterization of the location of pancreatic cancer and treatment volume extent with respect to nearby arteries with the goal of developing features to improve clinical predictions and decisions. Methods: Oncospace is a local learning health system that systematically captures clinical outcomes and all aspects of radiotherapy treatment plans, including overlap volume histograms (OVH) – a measure of spatial relationships between two structures. Minimum and maximum distances of PTV and OARs based on OVH, PTV volume, anatomic location by ICD-9 code, and surgical outcome were queried. Normalized distance to center from the left and right kidney was calculated to indicate tumor location and laterality. Distance to critical arteries (celiac, superior mesenteric, common hepatic) is validated by surgical status (borderline resectable, locally advanced converted to resectable). Results: There were 205 pancreas stereotactic body radiotherapy patients treated from 2009–2015 queried. Location/laterality of tumor based on kidney OVH show strong trends between location by OVH and by ICD-9. Compared to the locally advanced group, the borderline resectable group showed larger geometrical distance from critical arteries (p=0.03). Conclusion: Our platform enabled analysis of shape/size-location relationships. These data suggest that PTV volume and attention to distance between PTVs and surrounding OARs and major arteries may be

  12. REVIEW OF THE NEGOTIATION OF THE MODEL PROTOCOL ADDITIONAL TO THE AGREEMENT(S) BETWEEN STATE(S) AND THE INTERNATIONAL ATOMIC ENERGY AGENCY FOR THE APPLICATION OF SAFEGUARDS, INFCIRC/540 (Corrected) VOLUME III/III, IAEA COMMITTEE 24, DEVELOPMENT OF INFCIRC/540, ARTICLE-BY-ARTICLE REVIEW (1996-1997).

    Energy Technology Data Exchange (ETDEWEB)

    Rosenthal, M.D.; Houck, F.

    2010-01-01

    In this section of the report, the development of INFCIRC/540 is traced by a compilation of citations from the IAEA documents presented to the Board of Governors and the records of discussions in the Board that took place prior to the establishment of Committee 24 as well as the documents and discussions of that committee. The evolution of the text is presented separately for each article or, for the more complex articles, for each paragraph or group of paragraphs of the article. This section covers all articles, including those involving no issues. Background, issues, interpretations and conclusions, which were addressed in Volumes I, II, and III are not repeated here. The comments by states that are included are generally limited to objections and suggested changes. Requests for clarification or elaboration have been omitted, although it is recognized that such comments were sometimes veiled objections.

  13. Industrial Sector Technology Use Model (ISTUM): industrial energy use in the United States, 1974-2000. Volume 1. Primary model documentation. Book 1: Chapters I, II, and III

    Energy Technology Data Exchange (ETDEWEB)

    Bohn, R.E.; Herod, J.S.

    1978-06-19

    The model is designed to predict the commercial-market penetration of various energy technologies in the industrial sector out to the year 2000. The model represents the refinement and further development of the Industrial Sector Model developed for the Market Oriented Program Planning Study task force in 1977. The model assesses the comparative economic competitiveness of each technology and then uses these assessments to project each technology's anticipated market penetration. The introductory chapter provides logic and special terminology information of the model. The next sections deal with the input requirements and a discussion of the solution of the model.

  14. Efficacy evaluation of retrospectively applying the Varian normal breathing predictive filter for volume definition and artifact reduction in 4D CT lung patients.

    Science.gov (United States)

    Malone, Ciaran; Rock, Luke; Skourou, Christina

    2014-05-08

    Phase-based sorting of four-dimensional computed tomography (4D CT) datasets is prone to image artifacts due to patient's breathing irregularities that occur during the image acquisition. The purpose of this study is to investigate the effect of the Varian normal breathing predictive filter (NBPF) as a retrospective phase-sorting parameter in 4D CT. Ten 4D CT lung cancer datasets were obtained. The volumes of all tumors present, as well as the total lung volume, were calculated on the maximum intensity projection (MIP) images as well as each individual phase image. The NBPF was varied retrospectively within the available range, and changes in volume and image quality were recorded. The patients' breathing trace was analysed and the magnitude and location of any breathing irregularities were correlated to the behavior of the NBPF. The NBPF was found to have a considerable effect on the quality of the images in MIP and single-phase datasets. When used appropriately, the NBPF is shown to have the ability to account for and correct image artifacts. However, when turned off (0%) or set above a critical level (approximately 40%), it resulted in erroneous volume reconstructions with variations in tumor volume up to 26.6%. Those phases associated with peak inspiration were found to be more susceptible to changes in the NBPF. The NBPF settings selected prior to exporting the breathing trace for patients evaluated using 4D CT directly affect the accuracy of the targeting and volume estimation of lung tumors. Recommendations are made to address potential errors in patient anatomy introduced by breathing irregularities, specifically deep breath or cough irregularities, by implementing the proper settings and use of this tool.

  15. Orbitofrontal cortex volume in area 11/13 predicts reward devaluation, but not reversal learning performance, in young and aged monkeys.

    Science.gov (United States)

    Burke, Sara N; Thome, Alex; Plange, Kojo; Engle, James R; Trouard, Theodore P; Gothard, Katalin M; Barnes, Carol A

    2014-07-23

    The orbitofrontal cortex (OFC) and amygdala are both necessary for decisions based on expected outcomes. Although behavioral and imaging data suggest that these brain regions are affected by advanced age, the extent to which aging alters appetitive processes coordinated by the OFC and the amygdala is unknown. In the current experiment, young and aged bonnet macaques were trained on OFC- and amygdala-dependent tasks that test the degree to which response selection is guided by reward value and can be adapted when expected outcomes change. To assess whether the structural integrity of these regions varies with levels of performance on reward devaluation and object reversal tasks, volumes of areas 11/13 and 14 of the OFC, central/medial (CM), and basolateral (BL) nuclei of the amygdala were determined from high-resolution anatomical MRIs. With age, there were significant reductions in OFC, but not CM and BL, volume. Moreover, the aged monkeys showed impairments in the ability to associate an object with a higher value reward, and to reverse a previously learned association. Interestingly, greater OFC volume of area 11/13, but not 14, was significantly correlated with an animal's ability to anticipate the reward outcome associated with an object, and smaller BL volume was predictive of an animal's tendency to choose a higher value reward, but volume of neither region correlated with reversal learning. Together, these data indicate that OFC volume has an impact on monkeys' ability to guide choice behavior based on reward value but does not impact ability to reverse a previously learned association.

  16. Potential of right to left ventricular volume ratio measured on chest CT for the prediction of pulmonary hypertension: correlation with pulmonary arterial systolic pressure estimated by echocardiography

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Heon [Soon Chun Hyang University, Department of Radiology, Bucheon (Korea, Republic of); Kim, Seok Yeon [Seoul Medical Center, Department of Cardiology, Seoul (Korea, Republic of); Lee, Soo Jeong [Terarecon Korea, Seoul (Korea, Republic of); Kim, Jae Kyun [Chung-Ang University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Reddy, Ryan P.; Schoepf, U.J. [Medical University of South Carolina, Department of Radiology and Radiological Science and Division of Cardiology, Department of Medicine, Charleston, SC (United States)

    2012-09-15

    To investigate the correlation of right ventricular (RV) to left ventricular (LV) volume ratio measured by chest CT with pulmonary arterial systolic pressure (PASP) estimated by echocardiography. 104 patients (72.47 {+-} 13.64 years; 39 male) who had undergone chest CT and echocardiography were divided into two groups (hypertensive and normotensive) based upon an echocardiography-derived PASP of 25 mmHg. RV to LV volume ratios (RV{sub V}/LV{sub V}) were calculated. RV{sub V}/LV{sub V} was then correlated with PASP using regression analysis. The Area Under the Curve (AUC) for predicting pulmonary hypertension on chest CT was calculated. In the hypertensive group, the mean PASP was 46.29 {+-} 14.42 mmHg (29-98 mmHg) and there was strong correlation between the RV{sub V}/LV{sub V} and PASP (R = 0.82, p < 0.001). The intraobserver and interobserver correlation coefficients for RV{sub V}/LV{sub V} were 0.990 and 0.892. RV{sub V}/LV{sub V} was 1.01 {+-} 0.44 (0.51-2.77) in the hypertensive and 0.72 {+-} 0.14 (0.52-1.11) in the normotensive group (P <0.05). With 0.9 as the cutoff for RV{sub V}/LV{sub V}, sensitivity and specificity for predicting pulmonary hypertension over 40 mmHg were 79.5 % and 90 %, respectively. The AUC for predicting pulmonary hypertension was 0.87 RV/LV volume ratios on chest CT correlate well with PASP estimated by echocardiography and can be used to predict pulmonary hypertension over 40 mmHg with high sensitivity and specificity. (orig.)

  17. Prediction of Long-term Post-operative Testosterone Replacement Requirement Based on the Pre-operative Tumor Volume and Testosterone Level in Pituitary Macroadenoma.

    Science.gov (United States)

    Lee, Cheng-Chi; Chen, Chung-Ming; Lee, Shih-Tseng; Wei, Kuo-Chen; Pai, Ping-Ching; Toh, Cheng-Hong; Chuang, Chi-Cheng

    2015-11-05

    Non-functioning pituitary macroadenomas (NFPAs) are the most prevalent pituitary macroadenomas. One common symptom of NFPA is hypogonadism, which may require long-term hormone replacement. This study was designed to clarify the association between the pre-operative tumor volume, pre-operative testosterone level, intraoperative resection status and the need of long-term post-operative testosterone replacement. Between 2004 and 2012, 45 male patients with NFPAs were enrolled in this prospective study. All patients underwent transsphenoidal surgery. Hypogonadism was defined as total serum testosterone levels of testosterone to patients with defined hypogonadism or clinical symptoms of hypogonadism. Hormone replacement for longer than 1 year was considered as long-term therapy. The need for long-term post-operative testosterone replacement was significantly associated with larger pre-operative tumor volume (p = 0.0067), and lower pre-operative testosterone level (p = 0.0101). There was no significant difference between the gross total tumor resection and subtotal resection groups (p = 0.1059). The pre-operative tumor volume and testosterone level impact post-operative hypogonadism. By measuring the tumor volume and the testosterone level and by performing adequate tumor resection, surgeons will be able to predict post-operative hypogonadism and the need for long-term hormone replacement.

  18. Radiative transfer equation for predicting light propagation in biological media: comparison of a modified finite volume method, the Monte Carlo technique, and an exact analytical solution.

    Science.gov (United States)

    Asllanaj, Fatmir; Contassot-Vivier, Sylvain; Liemert, André; Kienle, Alwin

    2014-01-01

    We examine the accuracy of a modified finite volume method compared to analytical and Monte Carlo solutions for solving the radiative transfer equation. The model is used for predicting light propagation within a two-dimensional absorbing and highly forward-scattering medium such as biological tissue subjected to a collimated light beam. Numerical simulations for the spatially resolved reflectance and transmittance are presented considering refractive index mismatch with Fresnel reflection at the interface, homogeneous and two-layered media. Time-dependent as well as steady-state cases are considered. In the steady state, it is found that the modified finite volume method is in good agreement with the other two methods. The relative differences between the solutions are found to decrease with spatial mesh refinement applied for the modified finite volume method obtaining method is used for the time semi-discretization of the radiative transfer equation. An agreement among the modified finite volume method, Runge-Kutta method, and Monte Carlo solutions are shown, but with relative differences higher than in the steady state.

  19. Defining the Most Accurate Measurable Dimension(s of the Liver in Predicting Liver Volume Based on CT Volumetery and Reconstruction

    Directory of Open Access Journals (Sweden)

    Reza Saadat Mostafavi

    2010-05-01

    Full Text Available Background/Objective: The presence of liver volume has a great effect on diagnosis and management of different diseases such as lymphoproliferative conditions. "nPatients and Methods: Abdominal CT scan of 100 patients without any findings for liver disease (in history and imaging was subjected to volumetry and reconstruction. Along with the liver volume, in axial series, the AP diameter of the left lobe (in midline and right lobe (mid-clavicular and lateral maximum diameter of the liver in the mid-axiliary line and maximum diameter to IVC were calculated. In the coronal mid-axillary and sagittal mid-clavicular plane, maximum superior-inferior dimensions were calculated with their various combinations (multiplying. Regression analysis between dimensions and volume were performed. "nResults: The most accurate combination was the superior inferior sagittal dimension multiplied by AP diameter of the right lobe (R squared 0.78, P-value<0.001 and the most solitary dimension was the lateral dimension to IVC in the axial plane (R squared 0.57, P-value<0.001 with an interval of 9-11cm for 68% of normal. "nConclusion: We recommend the lateral maximum diameter of liver from surface to IVC in the axial plane in ultrasound for liver volume prediction with an interval of 9-11cm for 68% of normal. Out of this range is regarded as abnormal.

  20. Buried Volume Analysis for Propene Polymerization Catalysis Promoted by Group 4 Metals: a Tool for Molecular Mass Prediction

    KAUST Repository

    Falivene, Laura

    2015-10-02

    A comparison of the steric properties of homogeneous single site catalysts for propene polymerization using the percentage of buried volume (%VBur) as molecular descriptor is reported. The %VBur calculated on the neutral precursors of the active species seems to be a reliable tool to explain several experimental data related to the propene insertion and to the monomer chain transfer. Interestingly, a linear correlation between the buried volume calculated for a large set of neutral precursors and the energetic difference between propagation and termination steps calculated by DFT methods is found for Group 4 metal catalysts. The “master curves” derived for Ti, Zr and Hf confirm not only that the %VBur is an appropriate molecular descriptor for the systems considered but also that it could be used as tool for a large computational screening of new ligands.

  1. The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy-related morbidity.

    LENUS (Irish Health Repository)

    Khalid, S

    2012-05-01

    The aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of the transformation zone (LLETZ) might predict the relative risk of adverse obstetric outcome, specifically preterm labour (PTL).

  2. Critical Combinations of Radiation Dose and Volume Predict Intelligence Quotient and Academic Achievement Scores After Craniospinal Irradiation in Children With Medulloblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Thomas E., E-mail: thomas.merchant@stjude.org [Division of Radiation Oncology, St. Jude Children' s Research Hospital, Memphis, Tennessee (United States); Schreiber, Jane E. [Department of Psychology, St. Jude Children' s Research Hospital, Memphis, Tennessee (United States); Wu, Shengjie [Department of Biostatistcs, St. Jude Children' s Research Hospital, Memphis, Tennessee (United States); Lukose, Renin [Division of Radiation Oncology, St. Jude Children' s Research Hospital, Memphis, Tennessee (United States); Xiong, Xiaoping [Department of Biostatistcs, St. Jude Children' s Research Hospital, Memphis, Tennessee (United States); Gajjar, Amar [Department of Oncology, St. Jude Children' s Research Hospital, Memphis, Tennessee (United States)

    2014-11-01

    Purpose: To prospectively follow children treated with craniospinal irradiation to determine critical combinations of radiation dose and volume that would predict for cognitive effects. Methods and Materials: Between 1996 and 2003, 58 patients (median age 8.14 years, range 3.99-20.11 years) with medulloblastoma received risk-adapted craniospinal irradiation followed by dose-intense chemotherapy and were followed longitudinally with multiple cognitive evaluations (through 5 years after treatment) that included intelligence quotient (estimated intelligence quotient, full-scale, verbal, and performance) and academic achievement (math, reading, spelling) tests. Craniospinal irradiation consisted of 23.4 Gy for average-risk patients (nonmetastatic) and 36-39.6 Gy for high-risk patients (metastatic or residual disease >1.5 cm{sup 2}). The primary site was treated using conformal or intensity modulated radiation therapy using a 2-cm clinical target volume margin. The effect of clinical variables and radiation dose to different brain volumes were modeled to estimate cognitive scores after treatment. Results: A decline with time for all test scores was observed for the entire cohort. Sex, race, and cerebrospinal fluid shunt status had a significant impact on baseline scores. Age and mean radiation dose to specific brain volumes, including the temporal lobes and hippocampi, had a significant impact on longitudinal scores. Dichotomized dose distributions at 25 Gy, 35 Gy, 45 Gy, and 55 Gy were modeled to show the impact of the high-dose volume on longitudinal test scores. The 50% risk of a below-normal cognitive test score was calculated according to mean dose and dose intervals between 25 Gy and 55 Gy at 10-Gy increments according to brain volume and age. Conclusions: The ability to predict cognitive outcomes in children with medulloblastoma using dose-effects models for different brain subvolumes will improve treatment planning, guide intervention, and help

  3. Combined measurement of fetal lung volume and pulmonary artery resistance index is more accurate for prediction of neonatal respiratory distress syndrome in preterm fetuses: A Pilot Study.

    Science.gov (United States)

    Laban, Mohamed; Mansour, Ghada; El-Kotb, Ahmed; Hassanin, Alaa; Laban, Zina; Saleh, Abdelrahman

    2017-10-02

    To estimate optimal cut-off values for mean fetal lung volume (FLV) and pulmonary artery resistance index (PA-RI) as noninvasive measures to predict neonatal respiratory distress syndrome (RDS) in preterm fetuses. A prospective study conducted at Ain Shams University Maternity Hospital, Egypt from May 2015 to July 2017: eighty eligible women diagnosed with preterm labor were recruited at 32-36 weeks' gestation. Before delivery, three-dimensional ultrasound was used to estimate FLV using virtual organ computer-aided analysis (VOCAL), while PA-RI was measured by Doppler ultrasonography. A total of 80 women were examined. 37 (46%) of the newborns developed neonatal RDS. FLV was significantly lower in neonates who developed RDS (p = 0.04), whereas PARI was significantly higher in those who didn't (p = 0.02). Cut-off values of FLV ≤ 27.2 cm(3) and PARI ≥ 0.77 predicted the subsequent development of RDS. Combining both cut-offs generated a more sensitive and specific methodical approach for the prediction of RDS (sensitivity 100%, specificity 88.5%). Measurement of FLV or PA-RI can predict RDS in preterm fetuses. Combined use of both measures bolstered their predictive significance.

  4. Fracture Toughness Prediction for MWCNT Reinforced Ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Henager, Charles H.; Nguyen, Ba Nghiep

    2013-09-01

    This report describes the development of a micromechanics model to predict fracture toughness of multiwall carbon nanotube (MWCNT) reinforced ceramic composites to guide future experimental work for this project. The modeling work described in this report includes (i) prediction of elastic properties, (ii) development of a mechanistic damage model accounting for matrix cracking to predict the composite nonlinear stress/strain response to tensile loading to failure, and (iii) application of this damage model in a modified boundary layer (MBL) analysis using ABAQUS to predict fracture toughness and crack resistance behavior (R-curves) for ceramic materials containing MWCNTs at various volume fractions.

  5. The early predictive value of a decrease of metabolic tumor volume in repeated (18)F-FDG PET/CT for recurrence of locally advanced non-small cell lung cancer with concurrent radiochemotherapy.

    Science.gov (United States)

    Huang, Wei; Liu, Bo; Fan, Min; Zhou, Tao; Fu, Zheng; Zhang, Zicheng; Li, Hongsheng; Li, Baosheng

    2015-03-01

    The aim of this study is to investigate the value of [(18)F] fluorodeoxyglucose positron emission tomography/computed tomography ((18)F FDG PET/CT) to predict recurrence of patients with locally advanced non-small cell lung cancer (NSCLC) during the early stage of concurrent chemoradiotherapy (CCRT). A total of 53 stage III NSCLC patients without diabetics or undergoing surgery were enrolled in the prospective study. Those patients were evaluated by FDG PET before and following 40Gy radiotherapy (RT) with a concurrent cisplatin-based heterogeneous chemotherapy regimen. Semiquantitative assessment was used to determine maximum and mean SUVs (SUVmax/SUVmean) and metabolic tumor volume (MTV) of the primary tumor. The prognostic significance of PET/CT parameters and other clinical variables was assessed using Cox regression analyses. The cutoffs of PET/CT parameters which have been determined by the previous study were used to separate the groups with Kaplan-Meier curves. Recurrence rates at 1- and 2-years were 18.9% (10/53) and 50.9% (27/53) for all patients, respectively. Cox regression analysis showed that the only prognostic factor for recurrence was a decrease of MTV. Using the cutoff of 29.7%, a decrease of MTV can separate the patients into 2 groups with Kaplan-Meier curve successfully. The prospective study has reinforced the early predictive value of MTV in repeated (18)F-FDG PET/CT for recurrence in a subgroup of locally advanced NSCLC who underwent CCRT. A decrease of MTV in (18)F-FDG uptake by the primary tumor correlates with higher LRFS. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  6. Plasma Pro-C3 (N-terminal type III collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C

    DEFF Research Database (Denmark)

    Nielsen, Mette J.; Veidal, Sanne S.; Karsdal, Morten A.

    2015-01-01

    BACKGROUND & AIMS: Fibrogenesis results in release of certain extracellular matrix protein fragments into the circulation. We evaluated the diagnostic and prognostic performance of two novel serological markers, the precisely cleaved N-terminal propeptide of type III collagen (Pro-C3) and a peptide...... of helical collagen type III degradation (C3M), in chronic hepatitis C (CHC) patients. METHOD: Pro-C3 and C3M were measured by ELISA in plasma from CHC patients (n = 194) from a prior phase II antifibrotic trial (NCT00244751). Plasma samples and paired liver biopsies were obtained at baseline and after 1...

  7. The percent of cores positive for cancer in prostate needle biopsy specimens is strongly predictive of tumor stage and volume at radical prostatectomy.

    Science.gov (United States)

    Sebo, T J; Bock, B J; Cheville, J C; Lohse, C; Wollan, P; Zincke, H

    2000-01-01

    Pretreatment clinical staging of prostatic adenocarcinoma is important due to the increasing use of nonsurgical treatment options. Using multivariate analysis we assessed the predictive value of biopsy cores positive for cancer as a percent of all cores obtained as well as the percent surface area of needle cores involved with tumor for determining tumor volume and pathological stage at radical prostatectomy. Candidate variables for the multivariate model included patient age, clinical disease stage, serum prostate specific antigen (PSA) and Gleason score of cancer in the needle biopsy. We reviewed prostate needle biopsy findings in 207 consecutive patients who subsequently underwent radical retropubic prostatectomy. Each biopsy specimen was assessed for tumor involvement by calculating the percent of cores positive for cancer, percent surface area involved in all cores and Gleason score. Initial serum PSA and preoperative clinical disease stage were incorporated with biopsy results into a multivariate model to determine the parameters most predictive of pathological stage and tumor volume at radical retropubic prostatectomy. Of the 207 patients 152 (73.4%) had organ confined cancer and 55 (26.6%) had extraprostatic extension (pathological stages T2 and T3 or greater, respectively). Preoperative clinical staging information was available in 195 cases, in which disease was clinically confined and not confined in 184 (94.4%) and 11 (5.6%), respectively. Needle biopsy revealed a surface area of cancer ranging from less than 5% in 69 patients (33.3%) to 90% (mean 16, median 10). Univariate analysis demonstrated that the risk of extraprostatic extension was predicted by preoperative serum PSA (p = 0.027), the percent of cores and percent of surface area positive for cancer (p <0.0001), and Gleason score (p = 0.0009). Clinical stage approached significance (p = 0.071). Multivariate analysis showed that the percent of positive cores (p = 0.0003), initial serum PSA (p = 0

  8. Assessment and prediction of thoracic gas volume in pregnant women: an evaluation in relation to body composition assessment using air displacement plethysmography.

    Science.gov (United States)

    Henriksson, Pontus; Löf, Marie; Forsum, Elisabet

    2013-01-14

    Assessment of body fat (BF) in pregnant women is important when investigating the relationship between maternal nutrition and offspring health. Convenient and accurate body composition methods applicable during pregnancy are therefore needed. Air displacement plethysmography, as applied in Bod Pod, represents such a method since it can assess body volume (BV) which, in combination with body weight, can be used to calculate body density and body composition. However, BV must be corrected for the thoracic gas volume (TGV) of the subject. In non-pregnant women, TGV may be predicted using equations, based on height and age. It is unknown, however, whether these equations are valid during pregnancy. Thus, we measured the TGV of women in gestational week 32 (n 27) by means of plethysmography and predicted their TGV using equations established for non-pregnant women. Body weight and BV of the women was measured using Bod Pod. Predicted TGV was significantly (P = 0·033) higher than measured TGV by 6 % on average. Calculations in hypothetical women showed that this overestimation tended to be more pronounced in women with small TGV than in women with large TGV. The overestimation of TGV resulted in a small but significant (P = 0·043) overestimation of BF, equivalent to only 0·5 % BF, on average. A Bland-Altman analysis showed that the limits of agreement were narrow (from -1·9 to 2·9 % BF). Thus, although predicted TGV was biased and too high, the effect on BF was marginal and probably unimportant in many situations.

  9. Richard III

    DEFF Research Database (Denmark)

    Lauridsen, Palle Schantz

    2017-01-01

    Kort analyse af Shakespeares Richard III med fokus på, hvordan denne skurk fremstilles, så tilskuere (og læsere) langt henad vejen kan føle sympati med ham. Med paralleller til Netflix-serien "House of Cards"......Kort analyse af Shakespeares Richard III med fokus på, hvordan denne skurk fremstilles, så tilskuere (og læsere) langt henad vejen kan føle sympati med ham. Med paralleller til Netflix-serien "House of Cards"...

  10. Urinary engrailed-2 (EN2) levels predict tumour volume in men undergoing radical prostatectomy for prostate cancer

    DEFF Research Database (Denmark)

    Pandha, Hardev; Sørensen, Karina Dalsgaard; Ørntoft, Torben Falck

    2012-01-01

    AND METHODS: Archived patient samples from the Aarhus Prostate Cancer Project, Denmark, were assessed. Pre-treatment mid-stream urines, without preceding prostatic massage, were collected and stored at -80 °C. Urinary EN2 levels were measured by a recently published enzyme-linked immunosorbent assay. RESULTS...... associated with increasing tumour stage and closely reflected the volume of cancer in RP specimens. Given the ease of collection (no prostatic massage required) and the simplicity, low cost and robustness of the assay, EN2 may become a useful biomarker in not only identifying which patients have prostate...

  11. Prediction

    CERN Document Server

    Sornette, Didier

    2010-01-01

    This chapter first presents a rather personal view of some different aspects of predictability, going in crescendo from simple linear systems to high-dimensional nonlinear systems with stochastic forcing, which exhibit emergent properties such as phase transitions and regime shifts. Then, a detailed correspondence between the phenomenology of earthquakes, financial crashes and epileptic seizures is offered. The presented statistical evidence provides the substance of a general phase diagram for understanding the many facets of the spatio-temporal organization of these systems. A key insight is to organize the evidence and mechanisms in terms of two summarizing measures: (i) amplitude of disorder or heterogeneity in the system and (ii) level of coupling or interaction strength among the system's components. On the basis of the recently identified remarkable correspondence between earthquakes and seizures, we present detailed information on a class of stochastic point processes that has been found to be particu...

  12. Using Airborne Snow Observatory distributed snow water equivalent to predict seasonal inflow volumes and inform management decisions at the Hetch Hetchy Reservoir

    Science.gov (United States)

    Graham, C. B.; Painter, T. H.; Mazurkiewicz, A.

    2015-12-01

    Traditionally, estimates of seasonal streamflow volumes have been determined using statistical relationships to precipitation and snow depth measurements taken at widely spaced while geographically clustered gauges. While strong statistical relationships have been identified in some locations, these relationships are susceptible to breaking down during extreme conditions such as droughts or extremely wet years. The Airborne Snow Observatory (ASO) is a program where airplane mounted lidar is used to create snow-on and snow-off DEMs, yielding distributed estimates of snow water equivalent at the catchment scale. These estimates allow us, for the first time, to compare basin wide snow water equivalent to seasonal streamflow volumes. At the Tuolumne River basin in Yosemite National Park, Sierra Nevada Mountains, California, the ASO estimates of basin wide SWE are shown to be tightly correlated to seasonal streamflow volumes. These estimates are further improved when combined with precipitation measurements. These estimates appear to be more robust than traditional statistical methods, and have been used to improve predictions of inflows at the Hetch Hetchy Reservoir, the primary water source for the City and County of San Francisco and surrounding areas.

  13. Value of three-dimensional volume-rendering CT pulmonary contusion volume measurement in prediction of ARDS development%三维CT容积再现技术行肺挫伤容积测定预测ARDS的价值

    Institute of Scientific and Technical Information of China (English)

    王邵华; 周文勇; 赵明川; 张辉; 陈晓峰

    2014-01-01

    Objective To investigate the value of three-dimensional CT volume rendering in predicting ARDS following pulmonary contusion and identifying high-risk patients.Methods Seventy-one cases of pulmonary contusion (AIS > 2 points) confirmed by chest CT during an emergency admission between July 2010 and June 2011 were enrolled.Using computer-generated three-dimensional reconstruction,contusion volume was measured and expressed as a percentage of total lung volume.The admission data,such as blood gas analysis results,systolic arterial pressure,hematocrit,AIS,ISS,and injury distribution,were prospectively collected.Independent predictive factors of ARDS following pulmonary contusion was identified using logistic regression analysis and further estimation on accuracy and value of the predictors were performed.Influence of contusion volume percentage on clinical outcomes was detected.Results Of all,mean contusion volume percentage was (22.07 ± 14.50)% (range,5.60%-61.00%),which was not strongly correlated to the admission PaO2/FiO2 ratio (R2 =0.059).ARDS and infection were diagnosed in 31 cases and 25 cases respectively.PaO2/FiO2 ratio and contusion volume percentage were independent predictive factors of ARDS after pulmonary contusion.The best cut-off of contusion percentage in predicting ARDS development was 21.5% with a specificity of 80.0%,sensitivity of 71.0%,positive predictive value of 73.3%,and negative predictive value of 78.1%.Conclusion Three-dimensional CT volume rendering technique allows quantification of pulmonary contusion and identification of patients at high risk of ARDS,to whom further treatment may be directed.%目的 探讨三维CT容积再现技术行肺挫伤容积测定对预测肺挫伤后ARDS发生和识别高危患者的价值. 方法 选取2010年7月-2011年6月急诊胸部CT检查确诊肺挫伤中胸部AIS>2分的71例患者,通过计算机软件重建肺挫伤病变范围并三维容积再现技术测定肺挫伤病变

  14. DPYD Genotyping to Predict Adverse Events Following Treatment With Flourouracil-Based Adjuvant Chemotherapy in Patients With Stage III Colon Cancer

    DEFF Research Database (Denmark)

    Boige, Valérie; Vincent, Marc; Alexandre, Philippe;

    2016-01-01

    , Setting, and Participants: Pharmacogenetic substudy of 1545 patients who participated from December 2005 to November 2009 in the European Pan-European Trials in Alimentary Tract Cancer (PETACC)-8 randomized phase 3 clinical trial. Interventions: Patients with resected stage III CC were randomized...

  15. The Coastal Ocean Prediction Systems program: Understanding and managing our coastal ocean. Volume 2: Overview and invited papers

    Energy Technology Data Exchange (ETDEWEB)

    1990-05-15

    This document is a compilation of summaries of papers presented at the Coastal Ocean Prediction Systems workshop. Topics include; marine forecasting, regulatory agencies and regulations, research and application models, research and operational observing, oceanic and atmospheric data assimilation, and coastal physical processes.

  16. Predictive value of FSH, testicular volume, and histopathological findings for the sperm retrieval rate of microdissection TESE in nonobstructive azoospermia: a meta-analysis.

    Science.gov (United States)

    Li, Hao; Chen, Li-Ping; Yang, Jun; Li, Ming-Chao; Chen, Rui-Bao; Lan, Ru-Zhu; Wang, Shao-Gang; Liu, Ji-Hong; Wang, Tao

    2017-03-24

    We performed this meta-analysis to evaluate the predictive value of different parameters in the sperm retrieval rate (SRR) of microdissection testicular sperm extraction (TESE) in patients with nonobstructive azoospermia (NOA). All relevant studies were searched in PubMed, Web of Science, EMBASE, Cochrane Library, and EBSCO. We chose three parameters to perform the meta-analysis: follicle-stimulating hormone (FSH), testicular volume, and testicular histopathological findings which included three patterns: hypospermatogenesis (HS), maturation arrest (MA), and Sertoli-cell-only syndrome (SCOS). If there was a threshold effect, only the area under the summary receiver operating characteristic curve (AUSROC) was calculated. Otherwise, the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and the diagnostic odds ratio (DOR) were also calculated. Twenty-one articles were included in our study finally. There was a threshold effect among studies investigating FSH and SCOS. The AUSROCs of FSH, testicular volume, HS, MA, and SCOS were 0.6119, 0.6389, 0.6758, 0.5535, and 0.2763, respectively. The DORs of testicular volume, HS, and MA were 1.98, 16.49, and 1.26, respectively. The sensitivities of them were 0.80, 0.30, and 0.27, while the specificities of them were 0.35, 0.98, and 0.76, respectively. The PLRs of them were 1.49, 10.63, and 1.15, respectively. And NLRs were 0.73, 0.72, and 0.95, respectively. All the investigated factors in our study had limited predictive value. However, the histopathological findings were helpful to some extent. Most patients with HS could get sperm by microdissection TESE.

  17. Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer.

    Science.gov (United States)

    Mirjolet, Céline; Walker, Paul M; Gauthier, Mélanie; Dalban, Cécile; Naudy, Suzanne; Mazoyer, Frédéric; Martin, Etienne; Maingon, Philippe; Créhange, Gilles

    2016-11-04

    To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). A set of DVSE was recorded from V25 to V75 (increments of 5Gy) (both in % and in cc) for 180 men. The rAUC was calculated for doses ranging between 25Gy and 50Gy (rAUC25-50). Univariate and multivariate logistic regressions were performed to determine the relationship between DVSE or rAUC25-50 and the appearance of any acute GI toxicity. The rates of acute grade 1 (G1), G2 and G3 GI toxicities were 53.3 %, 10.6 % and 1.1 %, respectively. No G4+ toxicity was observed. Rectal V25 to V75 expressed in % were not predictive of G ≥ 1 GI toxicity (p ≥ 0.12) whereas rectal V25 to V50 expressed in cc did correlate with GI toxicity G ≥ 1 (p ≤ 0.04). rAUC25-50 expressed in cc. Gy correlated significantly with the occurrence of any acute GI toxicity G ≥ 1 (p = 0.027). The absolute volume of the rectum between 25Gy and 50Gy and rAUC25-50 could significantly predict any acute rectal toxicity in prostate cancer patients treated with daily IG-IMRT.

  18. [Comparison of resting energy expenditure determined by indirect calorimetry and estimated by predictive formulas in women with obesity degrees I to III].

    Science.gov (United States)

    Parra-Carriedo, Alicia; Cherem-Cherem, Loren; Galindo-De Noriega, Daniela; Díaz-Gutiérrez, Mary Carmen; Pérez-Lizaur, Ana Bertha; Hernández-Guerrero, César

    2013-01-01

    Introducción: La determinación del gasto energético en reposo (GER) se calcula cotidianamente a partir de fórmulas predictivas aunque el resultado varía dependiendo de la población. Objetivo: Comparar la determinación del GER mediante calorimetría indirecta y mediante las ecuaciones Harris-Benedict (HB), Mifflin (MF), Organización Mundial de la Salud (OMS), «Institute of Medicine» (IOM), Fórmula Rápida (FR) y Valencia (VA) en mujeres con grados de obesidad I a III. Métodos: Mujeres adultas mestizas mexicanas se incluyeron en el estudio y formaron 3 grupos a partir del índice de masa corporal (IMC). Obesidad grado I (IMC 30,0-34,9; n = 42), grado II (IMC 35,0-39,9; n = 38) y grado III (IMC > 40; n = 41). Se determinó el GER mediante calorimetría indirecta y mediante las ecuaciones antes señaladas. ANOVA de Kruskal-Wallis y la prueba de Dunn se emplearon para el análisis estadístico (p 30. En el grado III VA y FR muestran el mejor desempeño.

  19. Immunohistochemistry on IDH 1/2, ATRX, p53 and Ki-67 substitute molecular genetic testing and predict patient prognosis in grade III adult diffuse gliomas.

    Science.gov (United States)

    Takano, Shingo; Ishikawa, Eiichi; Sakamoto, Noriaki; Matsuda, Masahide; Akutsu, Hiroyoshi; Noguchi, Masayuki; Kato, Yukinari; Yamamoto, Tetsuya; Matsumura, Akira

    2016-04-01

    The molecular subgrouping of diffuse gliomas was recently found to stratify patients into prognostically distinct groups better than histological classification. Among several molecular parameters, the key molecules for the subtype diagnosis of diffuse gliomas are IDH mutation, 1p/19q co-deletion, and ATRX mutation; 1p/19q co-deletion is undetectable by immunohistochemistry, but is mutually exclusive with ATRX and p53 mutation in IDH mutant gliomas. Therefore, we applied ATRX and p53 immunohistochemistry instead of 1p/19q co-deletion analysis. The prognostic value of immunohistochemical diagnosis for Grade III gliomas was subsequently investigated. Then, the same immunohistochmical diagnostic approach was expanded for the evaluation of Grade II and IV diffuse glioma prognosis. The results indicate immunohistochemical analysis including IDH1/2, ATRX, p53, and Ki-67 index is valuable for the classification of diffuse gliomas, which is useful for the evaluation of prognosis, especially Grade III gliomas and lower-grade gliomas (i.e., Grade II and III).

  20. A nomogram based on age,prostate-specific antigen level,prostate volume and digital rectal examination for predicting risk of prostate cancer

    Institute of Scientific and Technical Information of China (English)

    Ping Tang; Hui Chen; Matthew Uhlman; Yu-Rong Lin; Xiang-Rong Deng; Bin Wang; Wen-Jun Yang; Ke-Ji Xie

    2013-01-01

    Nomograms for predicting the risk of prostate cancer developed using other populations may introduce sizable bias when applied to a Chinese cohort.In the present study,we sought to develop a nomogram for predicting the probability of a positive initial prostate biopsy in a Chinese population.A total of 535 Chinese men who underwent a prostatic biopsy for the detection of prostate cancer in the past decade with complete biopsy data were included.Stepwise logistic regression was used to determine the independent predictors of a positive initial biopsy.Age,prostate-specific antigen (PSA),prostate volume (PV),digital rectal examination (DRE) status,% free PSA and transrectal ultrasound (TRUS) findings were included in the analysis.A nomogram model was developed that was based on these independent predictors to calculate the probability of a positive initial prostate biopsy.A receiver-operating characteristic curve was used to assess the accuracy of using the nomogram and PSA levels alone for predicting positive prostate biopsy.The rate for positive initial prostate biopsy was 41.7% (223/535).The independent variables used to predict a positive initial prostate biopsy were age,PSA,PV and DRE status.The areas under the receiver-operating characteristic curve for a positive initial prostate biopsy for PSA alone and the nomogram were 79.7% and 84.8%,respectively.Our results indicate that the risk of a positive initial prostate biopsy can be predicted to a satisfactory level in a Chinese population using our nomogram.The nomogram can be used to identify and Counsel patients who should consider a prostate biopsy,ultimately enhancing accuracy in diagnosing prostate cancer.

  1. Commencement Bay Study. Volume III. Fish Wetlands.

    Science.gov (United States)

    1981-12-31

    area. Amish (1976) studied the occurrence of Philometra americana in English sole and rock sole of central Puget Sound. Amish’s sampling locations...Fisheries Biologist, Washington Department of Fisheries. Personal communication. Amish , R.A., 1976. The occurrence of the bloodworm Philometra americana...wildlife as well as the people of the Puyallup Nation who then inhabited the study area. Six major wetland habitat types have been recognized in the

  2. Design Options Study. Volume III. Qualitative Assessment.

    Science.gov (United States)

    1980-09-01

    would be obtained for a 500,000 lb- or 600,000 lb-payload- aircraft is uncertain. Assesment of De3ign-Option Substitutien TO summnarize the preceding...exhaust smoke and prohibit fuel venting to the atmosphere. In accordance with APR 80-36, as discussed previously in conjunction with the noise...Laboratory in terms of combustor efficiency, specific NO Xvalues, and specific levels Of Visible smoke . In the Most recent EPA proposals. emission

  3. Progress Report on Alzheimer Disease: Volume III.

    Science.gov (United States)

    National Inst. on Aging (DHHS/PHS), Bethesda, MD.

    This report summarizes advances in the understanding of Alzheimer's disease, the major cause of mental disability among older Americans. The demography of the disease is discussed, noting that approximately 2.5 million American adults are afflicted with the disease and that the large increase in the number of Alzheimer's disease patients is due to…

  4. Towboat Maneuvering Simulator. Volume III. Theoretical Description.

    Science.gov (United States)

    1979-05-01

    overshoot or :igzag maneuver;I - 1,2,3 .. . 6FL F- _’ Flan"ing rudder deflection rate a _ __ Steering rudder deflection rate Ship propulsion ratlol " elh...used with the equations are for the ship propulsion point (n - 1.0). The equations are written in terms of the complete barge flotillia towboat

  5. Great III - Cultural Resource Inventory. Volume 2

    Science.gov (United States)

    1982-05-01

    Historical Sketch of St. Louis University. Patrick Fox, • St. Louis. Historical look at the St. Louis mound complex. Holmes, Nathaniel 1868 Loess...Saint Louis to Me. St. Louis, Missouri: Hawthorn Pub- lishing Company, 1978. 305 p., illus. £ates, Giwendolyn Lewis 1976 Historic Sites Inventory for...Watercolors by Marilynne Bradley. St. Louis: Hawthorn Publishing Company, c. 1977. 259 p., illus. (part color). Includes: Old Courthouse, Old

  6. Influence of Software Tool and Methodological Aspects of Total Metabolic Tumor Volume Calculation on Baseline [18F]FDG PET to Predict Survival in Hodgkin Lymphoma.

    Directory of Open Access Journals (Sweden)

    Salim Kanoun

    Full Text Available To investigate the respective influence of software tool and total metabolic tumor volume (TMTV0 calculation method on prognostic stratification of baseline 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography ([18F]FDG-PET in newly diagnosed Hodgkin lymphoma (HL.59 patients with newly diagnosed HL were retrospectively included. [18F]FDG-PET was performed before any treatment. Four sets of TMTV0 were calculated with Beth Israel (BI software: based on an absolute threshold selecting voxel with standardized uptake value (SUV >2.5 (TMTV02.5, applying a per-lesion threshold of 41% of the SUV max (TMTV041 and using a per-patient adapted threshold based on SUV max of the liver (>125% and >140% of SUV max of the liver background; TMTV0125 and TMTV0140. TMTV041 was also determined with commercial software for comparison of software tools. ROC curves were used to determine the optimal threshold for each TMTV0 to predict treatment failure.Median follow-up was 39 months. There was an excellent correlation between TMTV041 determined with BI and with the commercial software (r = 0.96, p<0.0001. The median TMTV0 value for TMTV041, TMTV02.5, TMTV0125 and TMTV0140 were respectively 160 (used as reference, 210 ([28;154] p = 0.005, 183 ([-4;114] p = 0.06 and 143 ml ([-58;64] p = 0.9. The respective optimal TMTV0 threshold and area under curve (AUC for prediction of progression free survival (PFS were respectively: 313 ml and 0.70, 432 ml and 0.68, 450 ml and 0.68, 330 ml and 0.68. There was no significant difference between ROC curves. High TMTV0 value was predictive of poor PFS in all methodologies: 4-years PFS was 83% vs 42% (p = 0.006 for TMTV02.5, 83% vs 41% (p = 0.003 for TMTV041, 85% vs 40% (p<0.001 for TMTV0125 and 83% vs 42% (p = 0.004 for TMTV0140.In newly diagnosed HL, baseline metabolic tumor volume values were significantly influenced by the choice of the method used for determination of volume. However, no significant differences were found

  7. Pretreatment metabolic tumour volume is predictive of disease-free survival and overall survival in patients with oesophageal squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Lemarignier, Charles; Gouel, Pierrick [Centre Henri Becquerel and Rouen University Hospital, Department of Nuclear Medicine, Rouen (France); Di Fiore, Frederic [Rouen University Hospital, Department of Gastroenterology, Rouen (France); Centre Henri Becquerel, Department of Medical oncology, Rouen (France); Marre, Charline; Michel, Pierre [Rouen University Hospital, Department of Gastroenterology, Rouen (France); Hapdey, Sebastien; Modzelewski, Romain; Vera, Pierre [Centre Henri Becquerel and Rouen University Hospital, Department of Nuclear Medicine, Rouen (France); University of Rouen, QuantIF (Litis EA 4108 - FR CNRS 3638), Rouen (France); Dubray, Bernard [University of Rouen, QuantIF (Litis EA 4108 - FR CNRS 3638), Rouen (France); Centre Henri Becquerel and Rouen University Hospital, Department of Radiotherapy and Medical Physics, Rouen (France)

    2014-11-15

    It has been suggested that FDG PET has predictive value for the prognosis of treated oesophageal carcinoma. However, the studies reported in the literature have shown discordant results. The aim of this study was to determine whether pretherapy quantitative metabolic parameters correlate with patient outcomes. Included in the study were 67 patients with a histological diagnosis of oesophageal squamous cell carcinoma. Each patient underwent {sup 18}F-FDG PET (4.5 MBq/kg) before chemoradiotherapy. Quantitative analysis was performed using the following parameters: age, weight loss, location, N stage, OMS performance status, MTV{sub p} and MTV{sub p'} (metabolic tumour volume determined by two different physicians), MTV{sub 40%} (volume for a threshold of 40 % of SUVmax), MTV{sub a} (volume automatically determined with a contrast-based adaptive threshold method), SUVmax, SUVmean and TLG (total lesion glycolysis). MTV{sub p} and MTV{sub 40%} were highly correlated (Pearson's index 0.92). SUVmean{sub p} and SUVmean{sub 40%} were also correlated (Pearson's index 0.86), as were TLG{sub p} and TLG{sub 40%} (Pearson's index 0.98). Similarly, the parameters obtained with the adaptive threshold method (MTV{sub a}, SUVmean{sub a} and TLG{sub a}) were correlated with those obtained manually (MTV{sub p}, SUVmean{sub p} and TLG{sub p}). The manual metabolic tumour volume determination (MTV{sub p} and MTV{sub p'}) was reproducible. Multivariate analysis for disease-free survival (DFS) showed that a larger MTV{sub p} was associated with a shorter DFS (p = 0.004) and that a higher SUVmax was associated with a longer DFS (p = 0.02). Multivariate analysis for overall survival (OS) showed that a larger MTV{sub p} was associated with a shorter OS (p = 0.01) and that a tumour in the distal oesophagus was associated with a longer OS (p = 0.005). The associations among the other parameters were not statistically significant. Metabolic tumour volume is a major

  8. Future Performance Trend Indicators: A Current Value Approach to Human Resources Accounting. Report III. Multivariate Predictions of Organizational Performance Across Time.

    Science.gov (United States)

    Pecorella, Patricia A.; Bowers, David G.

    Multiple regression in a double cross-validated design was used to predict two performance measures (total variable expense and absence rate) by multi-month period in five industrial firms. The regressions do cross-validate, and produce multiple coefficients which display both concurrent and predictive effects, peaking 18 months to two years…

  9. DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer

    DEFF Research Database (Denmark)

    Nygård, Sune Boris; Vainer, Ben; Nielsen, Signe L;

    2016-01-01

    (PETACC3) where patients were randomized to 5-fluorouracil/folinic acid with or without additional irinotecan. TOP1 copy number status was analyzed by fluorescence in situ hybridization (FISH) using a TOP1/CEN20 dual-probe combination. TOP1 mRNA data were available from previous analyses. RESULTS: TOP1......RNA data were available from 580 patients with stage III disease. Benefit of irinotecan was restricted to patients characterized by TOP1 mRNA expression ≥ 3rd quartile (RFS: HRadjusted, 0.59; P = .09; OS: HRadjusted, 0.44; P = 0.03). The treatment by TOP1 mRNA interaction was not statistically significant...

  10. Sex-specific prediction of hypothalamic-pituitary-adrenal axis activity by pituitary volume during adolescence: a longitudinal study from 12 to 17 years of age.

    Science.gov (United States)

    Kaess, Michael; Simmons, Julian G; Whittle, Sarah; Jovev, Martina; Chanen, Andrew M; Yücel, Murat; Pantelis, Christos; Allen, Nicholas B

    2013-11-01

    To investigate the longitudinal relationship between pituitary gland volume (PGV) and parameters of hypothalamic-pituitary-adrenal axis (HPAA) functioning during adolescence. Participants were 49 adolescents (19 girls and 30 boys) selected from a larger longitudinal, population-based study of adolescent development. Assessments were conducted at three time points (S1, S2 and S3). MRI sessions were at S1 (age: M=12.62, SD=0.45 years) and S3 (M=16.48, SD=0.53 years) and multiple assessments of salivary cortisol were undertaken at S2 (M=15.51, SD=0.35 years). PGV was measured via previously validated manual tracing methods, and the cortisol awakening response (CAR) and diurnal slope (DSL) were used as indices of HPAA functioning. A significant sex-linked interaction was found for PGV at S1 predicting both CAR (p=0.025) and DSL (p=0.009) at S2. Specifically, PGV at S1 significantly predicted CAR (p=0.033) and DSL (p=0.010) in boys only, with no significant results found for girls. Neither CAR nor DSL at S2 predicted growth of PGV from S1 to S3. PGV in early adolescence predicted HPAA functioning in mid-adolescent boys but not in girls. The results suggest a significant influence of sex-specific development on the relationship between PGV and HPAA activity and reactivity. The findings have potential implications for understanding and interpreting sex-linked and stress related clinical disorders that emerge during mid-to-late adolescence. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. Predictions of the MCMI-III personality disorders from NEO-PI-R domains and facets: Comparison between American and Spanish samples

    Directory of Open Access Journals (Sweden)

    Anton Aluja

    2007-01-01

    Full Text Available Este estudio ex post facto analiza las relaciones entre las dimensiones y facetas del NEO-PI-R y los 14 trastornos de personalidad del MCMI-III en una muestra no clínica española (N = 674. Se exploran las diferencias y similitudes con los resultados de Dyce y O'Connor en una muestra americana con los mismos instrumentos. Como se esperaba, los análisis factoriales de facetas reteniendo cinco factores mostraron un modelo de relaciones muy similar entre ambas muestras, con un coeficiente de la congruencia total de 0,92, y coeficientes de congruencia de factor aceptables, salvo para el factor Apertura (0,68. En consonancia con las predicciones de Widiger y Widiger et al. los porcentajes de correlaciones significativas estaban alrededor de 60% en ambas muestras, y la mayoría coincidían. El análisis de regresión múltiple con dimensiones también reveló un gran parecido entre los resultados americanos y españoles, Neuroticismo fue el predictor más relacionado con los trastornos de personalidad. Se encontraron diferencias en las regresiones por facetas, aunque la varianza explicada fue prácticamente la misma que en las dimensiones. Se discute la validez transcultural y el valor predictivo del NEO-PI-R sobre los trastornos de personalidad del MCMI-III, junto con las ventajas relativas de las facetas sobre las dimensiones.

  12. RADTRAN III

    Energy Technology Data Exchange (ETDEWEB)

    Madsen, M M; Taylor, J M; Ostmeyer, R M; Reardon, P C

    1986-02-01

    A revised and updated version of the RADTRAN computer code is presented. This code has the capability to predict the radiological impacts associated with specific radioactive material shipment schemes and mode specific transport variables.

  13. Predicting ESR Peaks in Titanium (III, Vanadium (IV and Copper (II Complexes of Halo Ligands by NMR, ESR and NQR Techniques: A DFT Study

    Directory of Open Access Journals (Sweden)

    Harminder Singh

    2015-09-01

    Full Text Available 15 halo (I≥1/2 complexes of Ti (III, V (IV and Cu (II each possessing one unpaired electron were studied using DFT implemented in ADF.2010.02. Aten, NQCC and h parameters of metal ions and ligands were obtained from ESR/EPR program while their σ and δ parameters were given by NMR/EPR program after optimization of complexes. Ligands having same values of these 5 parameters were spatially equivalent and, thus, would undergo same hyperfine interaction. Experimental determination of ESR lines in Cu (II complexes became erroneous because the presence of both the large Jahn-Teller effect and the high value of its spin-orbit coupling constant (λ Cu (II = -830 cm-1 affect the A ten parameter adversely. Cryoscopic conditions, generally required, in ESR experiments of Ti (IIIand V (IVcomplexes were difficult to obtain and cumbersome to maintain.

  14. Whole-body metabolic tumour volume of {sup 18}F-FDG PET/CT improves the prediction of prognosis in small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Jong-Ryool; Chong, Ari; Min, Jung-Joon; Song, Ho-Chun; Bom, Hee-Seung [Chonnam National University Medical School and Hospital, Department of Nuclear Medicine, Gwangju (Korea, Republic of); Seo, Ji-Hyoung [Daegu Fatima Hospital, Department of Nuclear Medicine, Daegu (Korea, Republic of); Kim, Young-Chul [Chonnam National University Hwasun Hospital, Department of Internal Medicine, Hwasun-gun (Korea, Republic of)

    2012-06-15

    We investigated whether the whole-body metabolic tumour volume (WBMTV) measured by {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) can improve the prediction of prognosis in patients with small cell lung cancer (SCLC). We reviewed 106 consecutive patients (mean age 67 years, range 42-89 years, limited stage 45 patients, extensive stage 61 patients) with pathologically proven SCLC who underwent pretreatment FDG PET/CT. WBMTV and maximum standardized uptake value (SUV{sub max}) were measured in all malignant lesions. The Cox proportional hazards model was used with age, sex, performance status, lactate dehydrogenase (LDH), treatment, stage, SUV{sub max} and WBMTV to predict overall survival (OS) and progression-free survival (PFS). Subgroup analysis was performed using WBMTV combined with conventional staging and tumour node metastasis (TNM) staging. The uni- and multivariate analyses showed that both stage and WBMTV were independent prognostic factors for death and progression. Patients with high WBMTV were associated with poor prognosis compared with patients with low WBMTV [hazard ratio = 2.11 (95% confidence interval 1.31-3.39) for death (p = 0.002) and 1.80 (95% confidence interval 1.16-2.80) for progression (p = 0.009)]. Incorporation of conventional staging and WBMTV could classify four subgroups with different prognoses (log-rank test, p < 0.001). Incorporation of TNM staging and WBMTV could classify six subgroups with different prognoses (log-rank test, p < 0.001). WBMTV is an independent predictor for progression and death in patients with SCLC. Incorporation of WBMTV with TNM staging can provide a more detailed prediction of prognosis than WBMTV with conventional staging as well as tumour staging alone. (orig.)

  15. The early predictive value of a decrease of metabolic tumor volume in repeated {sup 18}F-FDG PET/CT for recurrence of locally advanced non-small cell lung cancer with concurrent radiochemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Wei, E-mail: weihuang@mcw.com [Department of Radiation Oncology (Chest Section), Shandong' s Key Laboratory of Radiation Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan 250117 (China); Liu, Bo; Fan, Min [Department of Internal Medicine Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan (China); Zhou, Tao [Department of Radiation Oncology (Chest Section), Shandong' s Key Laboratory of Radiation Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan 250117 (China); Fu, Zheng [PET/CT center, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan (China); Zhang, Zicheng; Li, Hongsheng [Department of Radiation Oncology (Chest Section), Shandong' s Key Laboratory of Radiation Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan 250117 (China); Li, Baosheng, E-mail: alvinbird@163.com [Department of Radiation Oncology (Chest Section), Shandong' s Key Laboratory of Radiation Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan 250117 (China)

    2015-03-15

    Highlights: •The patients underwent the second FDG PET during the early stage of concurrent chemoradiotherapy (CCRT). •To our knowledge, this could be the first study showing that the repeated FDG PET during the early stage of CCRT has added value by being a prognostic factor for recurrence of the locally advanced NSCLC patients. •This is a result of continuous research. •The decrease of MTV was the only significant risk factor for recurrence. -- Abstract: Purpose: The aim of this study is to investigate the value of [{sup 18}F] fluorodeoxyglucose positron emission tomography/computed tomography ({sup 18}F FDG PET/CT) to predict recurrence of patients with locally advanced non-small cell lung cancer (NSCLC) during the early stage of concurrent chemoradiotherapy (CCRT). Methods: A total of 53 stage III NSCLC patients without diabetics or undergoing surgery were enrolled in the prospective study. Those patients were evaluated by FDG PET before and following 40 Gy radiotherapy (RT) with a concurrent cisplatin-based heterogeneous chemotherapy regimen. Semiquantitative assessment was used to determine maximum and mean SUVs (SUVmax/SUVmean) and metabolic tumor volume (MTV) of the primary tumor. The prognostic significance of PET/CT parameters and other clinical variables was assessed using Cox regression analyses. The cutoffs of PET/CT parameters which have been determined by the previous study were used to separate the groups with Kaplan–Meier curves. Results: Recurrence rates at 1- and 2-years were 18.9% (10/53) and 50.9% (27/53) for all patients, respectively. Cox regression analysis showed that the only prognostic factor for recurrence was a decrease of MTV. Using the cutoff of 29.7%, a decrease of MTV can separate the patients into 2 groups with Kaplan–Meier curve successfully. Conclusion: The prospective study has reinforced the early predictive value of MTV in repeated {sup 18}F-FDG PET/CT for recurrence in a subgroup of locally advanced NSCLC who

  16. Tomo III

    OpenAIRE

    2015-01-01

    Memorias, histórico, físicas, crítico, apologéticas de la América Meridional con unas breves advertencias y noticias útiles, a los que de orden de Su Majestad, hubiesen de viajar y describir aquellas vastas regiones. Reino Animal. Tomo III. Por un anónimo americano en Cádiz por los años de 1757. Primera Parte Prólogo Artículo 1°De los cuadrúpedos útiles al hombre a varios usos y a su sustento. Vaca Caballos Carneros de la tierra, especie de camellos Vicuña Guanacos Puercos monteses Artículo 2...

  17. Graphics Gems III IBM version

    CERN Document Server

    Kirk, David

    1994-01-01

    This sequel to Graphics Gems (Academic Press, 1990), and Graphics Gems II (Academic Press, 1991) is a practical collection of computer graphics programming tools and techniques. Graphics Gems III contains a larger percentage of gems related to modeling and rendering, particularly lighting and shading. This new edition also covers image processing, numerical and programming techniques, modeling and transformations, 2D and 3D geometry and algorithms,ray tracing and radiosity, rendering, and more clever new tools and tricks for graphics programming. Volume III also includes a

  18. The predictive value of mean platelet volume, plateletcrit and red cell distribution width in the differentiation of autoimmune gastritis patients with and without type I gastric carcinoid tumors.

    Science.gov (United States)

    Tüzün, Ali; Keskin, Onur; Yakut, Mustafa; Kalkan, Cagdas; Soykan, Irfan

    2014-01-01

    Autoimmune gastritis is an autoimmune and inflammatory condition that may predispose to gastric carcinoid tumors or adenocarcinomas. The early diagnosis of these tumors is important in order to decrease morbidity and mortality. Platelet indices such as mean platelet volume and plateletcrit levels increase in inflammatory, infectious and malign conditions. The primary aim of this study was to explore wheter platelet indices and red cell distribution width have any predictive role in the discrimination of autoimmune gastritis patients with and without gastric carcinoid tumors. Also secondary aim of this study was to investigate whether any changes exist betwenn autoimmune gastritis and functional dyspepsia patients by means of platelet indices. Plateletcrit (0.22 ± 0.06 vs. 0.20 ± 0.03%, p gastritis patients compared to control group. Receiver operating curve analysis suggested that optimum plateletcrit cut-off point was 0.20% (AUC: 0.646), and 13.95% as the cut off value for red cell distribution width (AUC: 0.860). Although plateletcrit (0.22 ± 0.06 vs. 0.21 ± 0.04%, p = 0.220) and mean platelet volume (8.94 ± 1.44 vs. 8.68 ± 0.89 fl, p = 0.265) were higher in autoimmune gastritis patients without carcinoid tumor compared to patients with carcinoid tumors, these parameters were not statistically significant. Changes in plateletcrit and red cell distribution width values may be used as a marker in the discrimination of autoimmune gastritis and fucntional dyspepsia patients but not useful in patients with gastric carcinoid tumor type I.

  19. Prostate-specific Antigen Mass Density--A Measure Predicting Prostate Cancer Volume and Accounting for Overweight and Obesity-related Prostate-specific Antigen Hemodilution.

    Science.gov (United States)

    Kryvenko, Oleksandr N; Diaz, Mireya; Matoso, Andres; Kates, Max; Cohen, Jason; Swanson, Gregory P; Epstein, Jonathan I

    2016-04-01

    To test prostate-specific antigen mass density (PSAMD) as a predictor of total tumor volume (TTV) at radical prostatectomy (RP). We conducted a detailed pathologic analysis of 469 RP from men with NCCN low-risk prostate cancer who had Gleason score of 3 + 3 = 6 (grade group 1) at RP. We then compared the ability of PSA, PSA density (PSAD), PSA mass (PSAM-absolute amount of PSA in patient's circulation), and PSAM density (PSAM divided by prostate weight without seminal vesicles) to predict TTV at RP. PSAM was calculated by multiplying plasma volume (estimated body surface [weight, kg(0.425) × height, m(0.72) × 0.007184] × 1.67) by PSA. Performance of the above measures in different BMI categories was assessed. Kruskal-Wallis test was used to compare the means and Spearman's rank correlation coefficient to assess the correlations. The 469 men were normal weight (n = 129), overweight (n = 253), and obese (n = 87). Mean age of the patients' was 57.4 years and PSA of 4.53 ng/ml. Increase of prostate weight with body mass index (BMI) was reflected in PSAM (both P Prostate weight had stronger (negative) association with PSAMD (r = -0.394; <.001) than TTV. PSAMD is the biochemical measure with the best correlation with TTV at RP. Unlike other measures, it is not affected by BMI-related hemodilution. Thresholds should be established to use this more objective measure clinically in surveillance algorithms and in planning radical prostatectomy. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Sequential (gemcitabine/vinorelbine and concurrent (gemcitabine radiochemotherapy with FDG-PET-based target volume definition in locally advanced non-small cell lung cancer: first results of a phase I/II study

    Directory of Open Access Journals (Sweden)

    Stanzel Sven

    2007-06-01

    Full Text Available Abstract Background The aim of the study was to determine the maximal tolerated dose (MTD of gemcitabine every two weeks concurrent to radiotherapy, administered during an aggressive program of sequential and simultaneous radiochemotherapy for locally advanced, unresectable non-small cell lung cancer (NSCLC and to evaluate the efficacy of this regime in a phase II study. Methods 33 patients with histologically confirmed NSCLC were enrolled in a combined radiochemotherapy protocol. 29 patients were assessable for evaluation of toxicity and tumor response. Treatment included two cycles of induction chemotherapy with gemcitabine (1200 mg/m2 and vinorelbine (30 mg/m2 at day 1, 8 and 22, 29 followed by concurrent radiotherapy (2.0 Gy/d; total dose 66.0 Gy and chemotherapy with gemcitabine every two weeks at day 43, 57 and 71. Radiotherapy planning included [18F] fluorodeoxyglucose positron emission tomography (FDG PET based target volume definition. 10 patients were included in the phase I study with an initial gemcitabine dose of 300 mg/m2. The dose of gemcitabine was increased in steps of 100 mg/m2 until the MTD was realized. Results MTD was defined for the patient group receiving gemcitabine 500 mg/m2 due to grade 2 (next to grade 3 esophagitis in all patients resulting in a mean body weight loss of 5 kg (SD = 1.4 kg, representing 8% of the initial weight. These patients showed persisting dysphagia 3 to 4 weeks after completing radiotherapy. In accordance with expected complications as esophagitis, dysphagia and odynophagia, we defined the MTD at this dose level, although no dose limiting toxicity (DLT grade 3 was reached. In the phase I/II median follow-up was 15.7 months (4.1 to 42.6 months. The overall response rate after completion of therapy was 64%. The median overall survival was 19.9 (95% CI: [10.1; 29.7] months for all eligible patients. The median disease-free survival for all patients was 8.7 (95% CI: [2.7; 14.6] months. Conclusion

  1. Lack of XAGE-1b and NY-ESO-1 in metastatic lymph nodes may predict the potential survival of stage III melanoma patients.

    Science.gov (United States)

    Mori, Mariko; Funakoshi, Takeru; Kameyama, Kaori; Kawakami, Yutaka; Sato, Eiichi; Nakayama, Eiichi; Amagai, Masayuki; Tanese, Keiji

    2017-06-01

    The cancer-testis antigens (CTA) are a large family of tumor-associated antigens expressed by a variety of cancer cells and primitive germ cells of the adult testis and placenta. These tumor-restricted expressing patterns suggest that CTA would be ideal targets for tumor-specific immunotherapy. XAGE-1 is a CTA that was originally identified by computer-based screening, and four transcription variants, XAGE-1a, -1b, -1c and -1d, have been characterized to date. Although the presence of XAGE-1 transcripts has been reported in various cancers, the expression of XAGE-1b in melanoma has not been fully characterized. In this study, we performed immunohistochemical staining of XAGE-1b together with NY-ESO-1, a well-known CTA, in 113 melanoma samples obtained from 84 patients and evaluated their expression in tumor cells. The effects of expression on tumor progression and patient prognosis were analyzed. Both XAGE-1b and NY-ESO-1 were expressed at high levels in lymph node metastasis and skin metastasis samples compared with the primary site (P ESO-1). In a subgroup analysis of 22 patients with stage III lymph node metastasis, overall survival was significantly higher in the XAGE-1b and NY-ESO-1 double-negative group than in the other groups (P ESO-1 expression could have a positive influence on clinical outcome in patients with melanoma. © 2017 Japanese Dermatological Association.

  2. Prediction of intrinsic two-dimensional ferroelectrics in In2Se3 and other III2-VI3 van der Waals materials

    Science.gov (United States)

    Ding, Wenjun; Zhu, Jianbao; Wang, Zhe; Gao, Yanfei; Xiao, Di; Gu, Yi; Zhang, Zhenyu; Zhu, Wenguang

    2017-04-01

    Interest in two-dimensional (2D) van der Waals materials has grown rapidly across multiple scientific and engineering disciplines in recent years. However, ferroelectricity, the presence of a spontaneous electric polarization, which is important in many practical applications, has rarely been reported in such materials so far. Here we employ first-principles calculations to discover a branch of the 2D materials family, based on In2Se3 and other III2-VI3 van der Waals materials, that exhibits room-temperature ferroelectricity with reversible spontaneous electric polarization in both out-of-plane and in-plane orientations. The device potential of these 2D ferroelectric materials is further demonstrated using the examples of van der Waals heterostructures of In2Se3/graphene, exhibiting a tunable Schottky barrier, and In2Se3/WSe2, showing a significant band gap reduction in the combined system. These findings promise to substantially broaden the tunability of van der Waals heterostructures for a wide range of applications.

  3. Combination of baseline metabolic tumour volume and early response on PET/CT improves progression-free survival prediction in DLBCL

    Energy Technology Data Exchange (ETDEWEB)

    Mikhaeel, N.G.; Smith, Daniel [Guy' s and St Thomas' NHS Foundation Trust, Department of Clinical Oncology, London (United Kingdom); Dunn, Joel T.; Phillips, Michael; Barrington, Sally F. [King' s College London, PET Imaging Centre at St Thomas' Hospital, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Moeller, Henrik [King' s College London, Department of Cancer Epidemiology and Population Health, London (United Kingdom); Fields, Paul A.; Wrench, David [Guy' s and St Thomas' NHS Foundation Trust, Department of Haematology, London (United Kingdom)

    2016-07-15

    The study objectives were to assess the prognostic value of quantitative PET and to test whether combining baseline metabolic tumour burden with early PET response could improve predictive power in DLBCL. A total of 147 patients with DLBCL underwent FDG-PET/CT scans before and after two cycles of RCHOP. Quantitative parameters including metabolic tumour volume (MTV) and total lesion glycolysis (TLG) were measured, as well as the percentage change in these parameters. Cox regression analysis was used to test the relationship between progression-free survival (PFS) and the study variables. Receiver operator characteristics (ROC) analysis determined the optimal cut-off for quantitative variables, and Kaplan-Meier survival analysis was performed. The median follow-up was 3.8 years. As MTV and TLG measures correlated strongly, only MTV measures were used for multivariate analysis (MVA). Baseline MTV (MTV-0) was the only statistically significant predictor of PFS on MVA. The optimal cut-off for MTV-0 was 396 cm{sup 3}. A model combing MTV-0 and Deauville score (DS) separated the population into three distinct prognostic groups: good (MTV-0 < 400; 5-year PFS > 90 %), intermediate (MTV-0 ≥ 400+ DS1-3; 5-year PFS 58.5 %) and poor (MTV-0 ≥ 400+ DS4-5; 5-year PFS 29.7 %) MTV-0 is an important prognostic factor in DLBCL. Combining MTV-0 and early PET/CT response improves the predictive power of interim PET and defines a poor-prognosis group in whom most of the events occur. (orig.)

  4. Late Cardiac Toxicity After Mediastinal Radiation Therapy for Hodgkin Lymphoma: Contributions of Coronary Artery and Whole Heart Dose-Volume Variables to Risk Prediction.

    Science.gov (United States)

    Hahn, Ezra; Jiang, Haiyan; Ng, Angela; Bashir, Shaheena; Ahmed, Sameera; Tsang, Richard; Sun, Alexander; Gospodarowicz, Mary; Hodgson, David

    2017-08-01

    Mediastinal radiation therapy (RT) for Hodgkin lymphoma (HL) is associated with late cardiotoxicity, but there are limited data to indicate which dosimetric parameters are most valuable for predicting this risk. This study investigated which whole heart dosimetric measurements provide the most information regarding late cardiotoxicity, and whether coronary artery dosimetry was more predictive of this outcome than whole heart dosimetry. A random sample of 125 HL patients treated with mediastinal RT was selected, and 3-dimensional cardiac dose-volume data were generated from historical plans using validated methods. Cardiac events were determined by linking patients to population-based datasets of inpatient and same-day hospitalizations and same-day procedures. Variables collected for the whole heart and 3 coronary arteries included the following: Dmean, Dmax, Dmin, dose homogeneity, V5, V10, V20, and V30. Multivariable competing risk regression models were generated for the whole heart and coronary arteries. There were 44 cardiac events documented, of which 70% were ischemic. The best multivariable model included the following covariates: whole heart Dmean (hazard ratio [HR] 1.09, P=.0083), dose homogeneity (HR 0.94, P=.0034), male sex (HR 2.31, P=.014), and age (HR 1.03, P=.0049). When any adverse cardiac event was the outcome, models using coronary artery variables did not perform better than models using whole heart variables. However, in a subanalysis of ischemic cardiac events only, the model using coronary artery variables was superior to the whole heart model and included the following covariates: age (HR 1.05, Pcoronary artery models. However, when events were limited to ischemic cardiotoxicity, the coronary artery-based model was superior. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Computational prediction and experimental characterization of a "size switch type repacking" during the evolution of dengue envelope protein domain III (ED3).

    Science.gov (United States)

    Elahi, Montasir; Islam, Monirul M; Noguchi, Keiichi; Yohda, Masafumi; Toh, Hiroyuki; Kuroda, Yutaka

    2014-03-01

    Dengue viruses (DEN) are classified into four serotypes (DEN1-DEN4) exhibiting high sequence and structural similarities, and infections by multiple serotypes can lead to the deadly dengue hemorrhagic fever. Here, we aim at characterizing the thermodynamic stability of DEN envelope protein domain III (ED3) during its evolution, and we report a structural analysis of DEN4wt ED3 combined with a systematic mutational analysis of residues 310 and 387. Molecular modeling based on our DEN3 and DEN4 ED3 structures indicated that the side-chains of residues 310/387, which are Val(310)/Ile(387) and Met(310)/Leu(387) in DEN3wt and DEN4wt, respectively, could be structurally compensated, and that a "size switch type repacking" might have occurred at these sites during the evolution of DEN into its four serotypes. This was experimentally confirmed by a 10°C and 5°C decrease in the thermal stability of, respectively, DEN3 ED3 variants with Met(310)/Ile(387) and Val(310)/Leu(387), whereas the variant with Met(310)/Leu(387), which contains a double mutation, had the same stability as the wild type DEN3. Namely, the Met310Val mutation should have preceded the Leu387Ile mutation in order to maintain the tight internal packing of ED3 and thus its thermodynamic stability. This view was confirmed by a phylogenetic reconstruction indicating that a common DEN ancestor would have Met(310)/Leu(387), and the intermediate node protein, Val(310)/Leu(387), which then mutated to the Val(310)/Ile(387) pair found in the present DEN3. The hypothesis was further confirmed by the observation that all of the present DEN viruses exhibit only stabilizing amino acid pairs at the 310/387 sites.

  6. High total metabolic tumor volume in PET/CT predicts worse prognosis in diffuse large B cell lymphoma patients with bone marrow involvement in rituximab era.

    Science.gov (United States)

    Song, Moo-Kon; Yang, Deok-Hwan; Lee, Gyeong-Won; Lim, Sung-Nam; Shin, Seunghyeon; Pak, Kyoung June; Kwon, Seong Young; Shim, Hye Kyung; Choi, Bong-Hoi; Kim, In-Suk; Shin, Dong-Hoon; Kim, Seong-Geun; Oh, So-Yeon

    2016-03-01

    Bone marrow involvement (BMI) in diffuse large B cell lymphoma (DLBCL) was naively regarded as an adverse clinical factor. However, it has been unknown which factor would separate clinical outcomes in DLBCL patients with BMI. Recently, metabolic tumor volume (MTV) on positron emission tomography/computed tomography (PET/CT) was suggested to predict prognosis in several lymphoma types. Therefore, we investigated whether MTV would separate the outcomes in DLBCL patients with BMI. MTV on PET/CT was defined as an initial tumor burden as target lesion ≥ standard uptake value, 2.5 in 107 patients with BMI. Intramedullary (IM) MTV was defined as extent of BMI and total MTV was as whole tumor burden. 260.5 cm(3) and 601.2 cm(3) were ideal cut-off values for dividing high and low MTV status in the IM and total lymphoma lesions in Receiver Operating Curve analysis. High risk NCCN-IPI (phigh IM MTV status (phigh total MTV status (phigh risk NCCN-IPI (PFS, p=0.006; OS, p=0.013), concordant subtype (PFS, p=0.005; OS, p=0.007), and high total MTV status (PFS, p<0.001; OS, p<0.001) had independent clinical impacts. MTV had prognostic significances for survivals in DLBCL with BMI.

  7. The tumor-to-breast volume ratio (TBR) predicts cancer-specific survival in breast cancer patients who underwent modified radical mastectomy.

    Science.gov (United States)

    Wen, Jiahuai; Ye, Feng; Huang, Xiaojia; Li, Shuaijie; Yang, Lu; Xiao, Xiangsheng; Xie, Xiaoming

    2016-06-01

    Breast cancer is the most common cancer in women globally, and tumor size measured as the largest diameter of the tumor focus is currently used in tumor-lymph node-metastasis (TNM) staging for prognosis and treatment decisions. The present study utilized the tumor-to-breast volume ratio (TBR) to evaluate the relative tumor size and determined the prognostic impact of TBR on survival in patients with breast cancer. Two thousand twenty-five consecutive breast cancer patients who underwent modified radical mastectomy between January 2002 and December 2008 at Sun Yat-Sen University Cancer Center were enrolled in this retrospective study. Kaplan-Meier analysis was used to assess the prognostic effect of TBR on cancer-specific survival (CSS), and univariate log-rank test and multivariate Cox proportional hazards regression model were performed to identify independent prognostic factors. The optimal cutoff value of TBR was determined to be 1.70 %, and 1473 and 552 patients were categorized to low-TBR and high-TBR groups, respectively. In the whole patient cohort, CSS was significantly shorter in the high-TBR group (110.2 vs 128.5 months, P breast cancer patients (hazard ratio (HR) 1.489, 95 % CI 1.130-1.961, P = 0.005). High TBR was independently associated with poor prognosis in breast cancer patients. This variable may serve as a valuable parameter to predict the outcomes of breast cancer.

  8. Predictive and prognostic value of metabolic tumor volume (MTV in patients with laryngeal carcinoma treated by radiotherapy (RT / concurrent chemoradiotherapy (CCRT.

    Directory of Open Access Journals (Sweden)

    Kenichiro Yabuki

    Full Text Available To evaluate the predictive and prognostic value of pretreatment metabolic tumor volume (MTV in patients with treated by radiotherapy (RT or concurrent chemoradiotherapy (CCRT.We reviewed the records of 118 patients with newly diagnosed laryngeal carcinoma, who had been treated by RT or CCRT. Pretreatment positron emission tomography (PET was performed, and MTV values were obtained by contouring margins of standardized uptake value. Clinical factors and MTV were analyzed for their association with survival.Patients with residual disease showed a significantly higher MTV than those with a complete response (CR after primary treatment. Univariate analysis showed that the patients with a high MTV had a significantly lower disease-free survival (DFS (p < 0.001. Subsite (p = 0.010, T-stage (p < 0.001, nodal metastasis (p < 0.001 and clinical stage (p < 0.001 also correlated significantly with DFS. In the multivariate analysis, MTV and clinical stage were both found to be independent prognostic factors for DFS (p = 0.001, p = 0.034, respectively. The 3-year DFS for patients with a high MTV were significantly poorer than those with a low MTV (p < 0.001.MTV of the primary tumor is a significant prognostic factor for DFS in patients with laryngeal carcinoma treated by RT or CCRT. The results imply that MTV could be an important factor when planning treatment and follow-up for patients with laryngeal carcinoma.

  9. 成人标准肝体积预测公式的初步构建%Establishment of formula predicting adult standard liver volume for liver transplantation

    Institute of Scientific and Technical Information of China (English)

    王小飞; 严律南; 李波; 蓝翔; 袁丁; 张鸣; 魏永刚; 曾勇; 文天夫; 赵纪春

    2008-01-01

    目的 建立一个预测中国成人标准肝体积的公式.方法 收集2005年3月至2007年12月90例活体肝移植供者的临床资料,包括供者的性别(G)、年龄(Y)、身高(BH)、体重(BW)和术前CT扫描测量的全肝体积(TLV).分析TLV与上述其他指标的相关性,通过多重逐步线性回归得出预测标准肝体积的回归方程.并比较该公式和文献报道的公式预测的标准肝体积(ESLV)之间是否有差异.结果 90例供者的平均体重为(62.4±8.7)kg,平均TLV为(1319.1±167.0)ml,二者成正相关(r=0.655,P<0.01),可用公式TLV(ml)=12.5×BW(kg)+536.4来表示.与已发表文章中的公式相比,ESLV与TLV的差异均有统计学意义(P<0.05).结论 该研究建立了一个简单的更准确的预测中国成人标准肝体积的公式.%Objective To establish a favorable formula of estimation adult standard liver volume (SLV) based on the data of living donors for liver transplantation. Methods From March 2005 to December 2007,90 Adult-to-Adult living donor liver transplantation were performed. The donors' anthropemetric data of gender,year, body weight and body height was collected prospectively. The total liver volume (TLV) of 90 living donors was measured by computed tomography. The correlation between TLV and several factors including body weight index (BMI) and body surface area (BSA) were analyzed. Then multiple stepwise linear regression analysis was performed and a new equation predicting SLV to improve approximate TLV was determined. TLV was then compared with the estimation standard liver volume (ESLV) calculated using our formula and published formulas in literature previously. Results All the subjects had a mean body weight of (62.4±8.7) kg. The mean total liver volume was (1319.1±167.0) ml. There were positively correlated between TLV and body weight (BW), which could be expressed in the equation: TLV(ml)=12.5×BW (kg)+536.4(r2=0.43, P<0. 01). Compared TLV with ELSV, which were calculated using

  10. Biomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: predictive value of DNA-PK and phosphorylated ACC

    Science.gov (United States)

    Perrone, Francesco; Baldassarre, Gustavo; Indraccolo, Stefano; Signoriello, Simona; Chiappetta, Gennaro; Esposito, Franca; Ferrandina, Gabriella; Franco, Renato; Mezzanzanica, Delia; Sonego, Maura; Zulato, Elisabetta; Zannoni, Gian F.; Canzonieri, Vincenzo; Scambia, Giovanni; Sorio, Roberto; Savarese, Antonella; Breda, Enrico; Scollo, Paolo; Ferro, Antonella; Tamberi, Stefano; Febbraro, Antonio; Natale, Donato; Maio, Massimo Di; Califano, Daniela; Scognamiglio, Giosuè; Lorusso, Domenica; Canevari, Silvana; Losito, Simona; Gallo, Ciro; Pignata, Sandro

    2016-01-01

    Background No biomarker is available to predict prognosis of patients with advanced ovarian cancer (AOC) and guide the choice of chemotherapy. We performed a prospective-retrospective biomarker study within the MITO2 trial on the treatment of AOC. Patients and methods: MITO2 is a randomised multicentre phase 3 trial conducted with 820 AOC patients assigned carboplatin/paclitaxel (carboplatin: AUC5, paclitaxel: 175 mg/m², every 3 weeks for 6 cycles) or carboplatin/PLD-pegylated liposomal doxorubicin (carboplatin: AUC5, PLD: 30 mg/m², every 3 weeks for 6 cycles) as first line treatment. Sixteen biomarkers (pathways of adhesion/invasion, apoptosis, transcription regulation, metabolism, and DNA repair) were studied in 229 patients, in a tissue microarray. Progression-free and overall survival were analysed with multivariable Cox model. Results After 72 months median follow-up, 594 progressions and 426 deaths were reported; there was no significant difference between the two arms in the whole trial. No biomarker had significant prognostic value. Statistically significant interactions with treatment were found for DNA-dependent protein kinase (DNA-PK) and phosphorylated acetyl-coenzymeA carboxylase (pACC), both predicting worse outcome for patients receiving carboplatin/paclitaxel. Conclusion These data show that in presence of DNA-PK or pACC overexpression, carboplatin/paclitaxel might be less effective than carboplatin/PLD as first line treatment of ovarian cancer patients. Further validation of these findings is warranted. PMID:27655643

  11. Predicting Macrosomia

    National Research Council Canada - National Science Library

    Pates, Jason A; McIntire, Donald D; Casey, Brian M; Leveno, Kenneth J

    2008-01-01

    Objective. The purpose of this study was to evaluate the prediction of fetal macrosomia based on ultrasound estimates of fetal weight and amniotic fluid volume combined with clinical risk factors. Methods...

  12. Zooplankton biomass (displacement volume) data collected in North Atlantic during ICNAF NORWESTLANT projects I-III in 1963 by different countries, data were acquired from the NMFS-COPEPOD database (NODC Accession 0070201)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Zooplankton biomass data (displacement volume) collected in North Atlantic during ICNAF (International Convention for the Northwest Atlantic Fisheries) NORWESTLANT...

  13. Zooplankton biomass (displacement and settled volume) data collected during the International Cooperative Investigations of the Tropical Atlantic EQUALANT I, EQUALANT II, and EQUALANT III projects from 1963-02-15 to 1964-07-09 (NODC Accession 0071432)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Zooplankton biomass (displacement and settled volume) data collected during the International Cooperative Investigations of the Tropical Atlantic EQUALANT I,...

  14. Mechatronic systems and materials III

    CERN Document Server

    Gosiewski, Zdzislaw

    2009-01-01

    This very interesting volume is divided into 24 sections; each of which covers, in detail, one aspect of the subject-matter: I. Industrial robots; II. Microrobotics; III. Mobile robots; IV. Teleoperation, telerobotics, teleoperated semi-autonomous systems; V. Sensors and actuators in mechatronics; VI. Control of mechatronic systems; VII. Analysis of vibration and deformation; VIII. Optimization, optimal design; IX. Integrated diagnostics; X. Failure analysis; XI. Tribology in mechatronic systems; XII. Analysis of signals; XIII. Measurement techniques; XIV. Multifunctional and smart materials;

  15. Memoir and Scientific Correspondence of the Late Sir George Gabriel Stokes, Bart. 2 Volume Paperback Set

    Science.gov (United States)

    Stokes, George Gabriel; Larmor, Joseph

    2010-06-01

    Volume 1: Preface; Part I. Personal and Biographical; Part II. General Scientific Career; Part IIIa. Special Scientific Correspondence; Appendix; Index. Volume 2: Part. III. Special Scientific Correspondence; Index.

  16. Reduction in Tumor Volume by Cone Beam Computed Tomography Predicts Overall Survival in Non-Small Cell Lung Cancer Treated With Chemoradiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Jabbour, Salma K., E-mail: jabbousk@cinj.rutgers.edu [Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, New Brunswick, New Jersey (United States); Kim, Sinae [Division of Biometrics, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, New Brunswick, New Jersey (United States); Department of Biostatistics, School of Public Health, Rutgers University, New Brunswick, New Jersey (United States); Haider, Syed A. [Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, New Brunswick, New Jersey (United States); Xu, Xiaoting [Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, New Brunswick, New Jersey (United States); Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Soochow (China); Wu, Alson [Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, New Brunswick, New Jersey (United States); Surakanti, Sujani; Aisner, Joseph [Division of Medical Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, New Brunswick, New Jersey (United States); Langenfeld, John [Division of Surgery, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, New Brunswick, New Jersey (United States); Yue, Ning J.; Haffty, Bruce G.; Zou, Wei [Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, New Brunswick, New Jersey (United States)

    2015-07-01

    Purpose: We sought to evaluate whether tumor response using cone beam computed tomography (CBCT) performed as part of the routine care during chemoradiation therapy (CRT) could forecast the outcome of unresectable, locally advanced, non-small cell lung cancer (NSCLC). Methods and Materials: We manually delineated primary tumor volumes (TV) of patients with NSCLC who were treated with radical CRT on days 1, 8, 15, 22, 29, 36, and 43 on CBCTs obtained as part of the standard radiation treatment course. Percentage reductions in TV were calculated and then correlated to survival and pattern of recurrence using Cox proportional hazard models. Clinical information including histologic subtype was also considered in the study of such associations. Results: We evaluated 38 patients with a median follow-up time of 23.4 months. The median TV reduction was 39.3% (range, 7.3%-69.3%) from day 1 (D1) to day 43 (D43) CBCTs. Overall survival was associated with TV reduction from D1 to D43 (hazard ratio [HR] 0.557, 95% CI 0.39-0.79, P=.0009). For every 10% decrease in TV from D1 to D43, the risk of death decreased by 44.3%. For patients whose TV decreased ≥39.3 or <39.3%, log-rank test demonstrated a separation in survival (P=.02), with median survivals of 31 months versus 10 months, respectively. Neither local recurrence (HR 0.791, 95% CI 0.51-1.23, P=.29), nor distant recurrence (HR 0.78, 95% CI 0.57-1.08, P=.137) correlated with TV decrease from D1 to D43. Histologic subtype showed no impact on our findings. Conclusions: TV reduction as determined by CBCT during CRT as part of routine care predicts post-CRT survival. Such knowledge may justify intensification of RT or application of additional therapies. Assessment of genomic characteristics of these tumors may permit a better understanding of behavior or prediction of therapeutic outcomes.

  17. Injury rates in martial art athletes: anthropometric parameters and training volume, but not foot morphology indexes, are predictive risk factors for lower limb injuries.

    Science.gov (United States)

    Vitale, Jacopo A; Bassani, Tito; Galbusera, Fabio; Bianchi, Alberto; Martinelli, Nicolò

    2017-09-22

    Previous studies attempted to identify possible risk factors for acute and overuse injuries in several sports disciplines such as running, gymnastics or team sports. Given the lack of scientific works focused on risk factors for lower limb injuries in martial arts, the present study was aimed to investigate foot anatomy, anthropometric measures, and other background information as possible risk factors of injury in barefoot athletes practicing judo, karate, kung fu, thai boxe, or aikido. In addition, the injury rates were evaluated in relation with the different martial art styles. One group of 130 martial artists was retrospectively evaluated. Data of three foot morphological variables were collected: navicular height (NH), navicular drop (ND) and the rear foot (RF). In addition, each participant filled an interview questionnaire providing the following information: age, sex, body weight, height, BMI, hours of training per week, the kind of injury occurred to the lower limbs in the preceding year. Of 130 subjects, 70 (53.8%) did not sustain injuries, 35 (27.0%) suffered an acute injury and the remaining 25 (19.2%) reported an overuse injury. No significant differences were observed in the injury rates in relation to style and kind of martial art. Age, training volume and BMI were found as significant predictors of injury, while NH, ND and RF were not able to predict acute or overuse injury at lower limbs. The injury rates were similar in karate, judo, kung fu, aikido, and thai boxe. The foot morphology variables were not related with the presence or absence of acute and overuse injuries. Conversely, older and heavier martial artists, performing more hours of barefoot training, are at higher risk of acute and overuse injury. Athletic trainers should strongly take into account the present information in order to develop more accurate and specific injury prevention programs for martial artists.

  18. The use of Numerical Weather Prediction and a Lagrangian transport (NAME-III) and dispersion (ASHFALL) models to explain patterns of observed ash deposition and dispersion following the August 2012 Te Maari, New Zealand eruption

    Science.gov (United States)

    Turner, Richard; Moore, Stuart; Pardo, Natalia; Kereszturi, Gabor; Uddstrom, Michael; Hurst, Tony; Cronin, Shane

    2014-10-01

    The August 6, 2012 Te Maari, New Zealand eruption produced a very small ash-dominated plume (~ 230,000 m3, 8-10 km high) that was rapidly and widely dispersed, covering 1600 km2 within an hour. This paper documents for the August 6, 2012 Te Maari eruption the upper level (troposphere) plume movement based on ash-detection algorithms applied to IR satellite imagery. It also presents the distribution of airborne ash and wind-influenced ashfall as determined by NAME-III aerial dispersion modelling using observed particle characteristics and grain size distribution measurements (that are also presented) and compares the ashfall with observations. The upper level (troposphere) ash movement was also evaluated from ash-detection algorithms, applied to infra-red satellite imagery and the resulting distributions were compared to those forecast by the numerical dispersion models. Forecasts of upper level ash-dispersion patterns explained the satellite imagery observations well, predicting the correct altitudes when using plausible ash size distributions and release levels. Patterns in proximal ashfall could only be partly explained by aerial dispersal of large particles released at low altitudes in the eruption column. The extreme distal (100-150 km away) observed ashfall distributions also cannot be fully explained by NAME-III when using: reasonably prescribed initial particle size distributions, eruption column height, eruption timing, well forecast winds, and dry sedimentation processes. Aggregation and ice nucleation effects (observed in deposits) were not included in the ash dispersion model, but appear as a plausible mechanism to account for the observed fraction of wind dispersed ash particles < 30 μm deposited but not captured by the models.

  19. A modified free-volume-based model for predicting vapor-liquid and solid-liquid equilibria for size asymmetric systems

    DEFF Research Database (Denmark)

    Radfarnia, H.R.; Ghotbi, C.; Taghikhani, V.;

    2005-01-01

    Flory-Huggins model, replacing the molar volume with a free-volume (FV) term. Using an extensive database for athermal polymer solutions at finite dilution, the single parameter of the model has been well adjusted. The results obtained from the model proposed in this work were favorably compared...

  20. Major depressive episodes over the course of 7 years and hippocampal subfield volumes at 7 tesla MRI: the PREDICT-MR study.

    Science.gov (United States)

    Wisse, L E M; Biessels, G J; Stegenga, B T; Kooistra, M; van der Veen, P H; Zwanenburg, J J M; van der Graaf, Y; Geerlings, M I

    2015-04-01

    Smaller hippocampal volumes have been associated with major depressive disorder (MDD). The hippocampus consists of several subfields that may be differentially related to MDD. We investigated the association of occurrence of major depressive episodes (MDEs), assessed five times over seven years, with hippocampal subfield and entorhinal cortex volumes at 7 tesla MRI. In this prospective study of randomly selected general practice attendees, MDEs according to DSM-IV-R criteria were assessed at baseline and after 6, 12, 39 and 84 months follow-up. At the last follow-up, a T2 (0.7 mm(3)) 7 tesla MRI scan was obtained in 47 participants (60±10 years). The subiculum, cornu ammonis (CA) 1 to 3, dentate gyrus&CA4 and entorhinal cortex volumes were manually segmented according a published protocol. Of the 47 participants, 13 had one MDE and 5 had multiple MDEs. ANCOVAs, adjusted for age, sex, education and intracranial volume, revealed no significant differences in hippocampal subfield or entorhinal cortex volumes between participants with and without an MDE in the preceding 84 months. Multiple episodes were associated with smaller subiculum volumes (B=-0.03 mL/episode; 95% CI -0.06; -0.003), but not with the other hippocampal subfield volumes, entorhinal cortex, or total hippocampal volume. A limitation of this study is the small sample size which makes replication necessary. In this exploratory study, we found that an increasing number of major depressive episodes was associated with smaller subiculum volumes in middle-aged and older persons, but not with smaller volumes in other hippocampal subfields or the entorhinal cortex. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Culture of Schools. Final Report. Volume IV.

    Science.gov (United States)

    American Anthropological Association, Washington, DC.

    The final volume of this 4-volume report contains further selections from "Anthropological Perspectives on Education," a monograph to be published by Basic Books of New York. (Other selections are in Vol. III, SP 003 902.) Monograph selections appearing in this volume are: "Great Tradition, Little Tradition, and Formal Education;""Indians,…

  2. Prédiction des propriétés volumétriques des hydrocarbures par une translation de volume améliorée Prediction of the Volumetric Properties of Hydrocarbons with an Improved Volume Translation Method

    Directory of Open Access Journals (Sweden)

    Ungerer P.

    2006-12-01

    -ci, s'avère cohérente avec les règles de mélange quand l'on regroupe plusieurs constituants en un pseudo-constituant. Son application aux mélanges pétroliers apparaît donc prometteuse. This summary contains formulas (*** which can not be displayed on the screen. Following the work of Péneloux et al. (1982 , several attempts have been made to improve density calculations from equations of state by the use of alternative volume translation methods (Soreide, 1989; Magoulas and Tassios, 1990; Coniglio, 1993. The present work aims at improving these predictions, particularly in the case of oil and gas reservoirs (temperature up to 200°C and pressures as high as 120 MPa, using the Peng-Robinson equation of state. As volume translation methods sometimes show inconsistencies at high pressure (e. g. , negative thermal expansion coefficient we had to develop an original expression. For this purpose, we used high pressure density measurements instead of saturated liquid densities. Several pure hydrocarbons from various families were considered : C6 to C40 n-alkanes, cyclohexane, C6 to C12 monoaromatics. Within a good approximation, the volume translation c is thus shown to follow a linear dependancy with temperature and with molecular weight :c(T = (0. 023 - 0. 00056 MWT + (- 34. 5 + 0. 4666 MWwhere c is in cm³/mol, T in K and MW in g/mol. When this expression is used, average errors at high pressure are low (less than 3% for the C6 to C13 hydrocarbons investigated. For heavier hydrocarbons, its predictions are sensitive to critical properties and the following expression is recommended :(***where v(Tref, Pref is the liquid molar volume computed by the untranslated equation of state in the same conditions as those where a density measurement (pref is available. With the exception of the near-critical region, the method is still accurate at low pressure. The method does not display the inconsistencies of previous methods, and it is also shown to be consistent with mixing

  3. III-V semiconductor materials and devices

    CERN Document Server

    Malik, R J

    1989-01-01

    The main emphasis of this volume is on III-V semiconductor epitaxial and bulk crystal growth techniques. Chapters are also included on material characterization and ion implantation. In order to put these growth techniques into perspective a thorough review of the physics and technology of III-V devices is presented. This is the first book of its kind to discuss the theory of the various crystal growth techniques in relation to their advantages and limitations for use in III-V semiconductor devices.

  4. Updating quasar bolometric luminosity corrections - III. [O iii] bolometric corrections

    Science.gov (United States)

    Pennell, Alison; Runnoe, Jessie C.; Brotherton, M. S.

    2017-06-01

    We present quasar bolometric corrections using the [O III] λ 5007 narrow emission line luminosity based on the detailed spectral energy distributions of 53 bright quasars at low to moderate redshift (0.0345 diversity, introduces scatter into the L_{[O III]}-Liso relationship. We found that the {[O III]} bolometric correction can be significantly improved by adding a term including the equivalent width ratio R_{Fe II} ≡ EW_{{Fe II}}/EW_{Hβ }, which is an EV1 indicator. Inclusion of R_{Fe II} in predicting Liso is significant at nearly the 3σ level and reduces the scatter and systematic offset of the luminosity residuals. Typically, {[O III]} bolometric corrections are adopted for Type 2 sources where the quasar continuum is not observed and in these cases, R_{Fe II} cannot be measured. We searched for an alternative measure of EV1 that could be measured in the optical spectra of Type 2 sources but were unable to identify one. Thus, the main contribution of this work is to present an improved {[O III]} bolometric correction based on measured bolometric luminosities and highlight the EV1 dependence of the correction in Type 1 sources.

  5. An SVM-based method for predicting cigarette sales volume%一种基于支持向量机的卷烟销量预测方法

    Institute of Scientific and Technical Information of China (English)

    武牧; 林慧苹; 李素科; 吴明治; 王治国; 吴高峰

    2016-01-01

    为解决现有线性回归方法对市级卷烟销量预测研究效果不佳等问题,基于支持向量机(SVM,Support vector machine)设计并实现了一种市级卷烟销量预测方法.以湖南中烟工业有限责任公司卷烟销量为研究对象,将支持向量机(SVM)方法应用到卷烟销量预测中,提出了基于SVM的卷烟销量预测混合方法(SHPM,SVM-based hybrid prediction method).将SHPM与线性回归方法、ARIMA(Autoregressive integrated moving average)方法、SVM方法进行了市级卷烟销量预测的对比实验,结果表明:将SVM方法应用到卷烟销量预测中是可行的.在市级卷烟销量预测上,SHPM预测结果误差相比SVM方法降低9.58%,比线性回归方法降低11.83%,比ARIMA方法降低45.79%.因此,SHPM是一种有效的市级卷烟销量预测方法.%Not satisfied with the accuracy of cigarette sales volume prediction with linear regression method, an SHPM (SVM-based hybrid prediction method) was proposed based on SVM (Support vector machine) by taking the sales volume of China Tobacco Hunan Industrial Company Limited as objects. Municipal level cigarette sales volume predicted separately by SHPM, linear regression, ARIMA (autoregressive integrated moving average) and SVM were compared and analyzed. The results showed that it was feasible to predict cigarette sales volumes with SVM method. The prediction errors against SVM, linear regression and ARIMA reduced by 9.58%, 11.83% and 45.79%, respectively; SHPM prediction method was more effective.

  6. Volume Entropy

    CERN Document Server

    Astuti, Valerio; Rovelli, Carlo

    2016-01-01

    Building on a technical result by Brunnemann and Rideout on the spectrum of the Volume operator in Loop Quantum Gravity, we show that the dimension of the space of the quadrivalent states --with finite-volume individual nodes-- describing a region with total volume smaller than $V$, has \\emph{finite} dimension, bounded by $V \\log V$. This allows us to introduce the notion of "volume entropy": the von Neumann entropy associated to the measurement of volume.

  7. Measurement of Second-trimester Placental Volume by Ultrasound: Prediction of Fetal Intrauterine Growth%超声测量中孕期胎盘容积预测胎儿发育

    Institute of Scientific and Technical Information of China (English)

    王慧芳; 李慰玑; 黄幼珍; 王新房

    1993-01-01

    本文对中孕期胎盘容积的增长和胎盘循环进行了纵向性监测,发现中孕期胎盘容积增长较快,且有二个加速期,即15~17孕周,19~21孕周.胎盘容积发育不良或胎盘循环功能受损,均能影响胎儿宫内生长发育.中孕期胎盘发育的超声监测对预测胎儿宫内生长发育迟缓有价值,而中孕期胎儿生物学测量对胎儿宫内生长发育迟缓预测价值不大.%Placental volume includes the placental cellular mass and placental circulating blood volume.The development of placental volume was not even during pregnancy.A longitudinal ultrasonic study of placental volume and placental circulation were performed.The results were that placental vol-nme developed rapidly during second-trimester and has two quickened phases at 15~17 weeks and 19 ~21 weeks of gestation respectively.Both abnormal placental volume and placental circulation could in-fluence the fetal growth.The developmentof second-trimester placental volome monitored by ultra-sound Was proved to be valuable in predicting fetal intrauterine growth retardation(IUGR).Fetal biom-etry during second-trimester has little value in predicting IUGR.

  8. Predição de peso ao nascimento pela ultra-sonografia tridimensional usando o volume do braço fetal: resultados preliminares Prediction of birth weight by three-dimensional ultrasonography using fetal upper arm volume: preliminary results

    Directory of Open Access Journals (Sweden)

    Márcio Fragoso Vieira

    2008-04-01

    Full Text Available OBJETIVO: determinar a acurácia do volume do braço fetal aferido pela ultra-sonografia tridimensional (USG3D na predição de peso ao nascimento. MÉTODOS: realizou-se um estudo prospectivo, do tipo corte transversal, com 25 gestantes sem anormalidades estruturais ou cromossomopatias. Os parâmetros bidimensionais (diâmetro biparietal, circunferência abdominal e comprimento do fêmur e o volume do braço fetal pela USG3D foram avaliados em até 48 horas antes do parto. Para o cálculo do volume do braço fetal, utilizou-se o método multiplanar, por meio de múltiplos planos seqüenciais com intervalos de 5,0 mm. Realizaram-se regressões polinomiais para se determinar a melhor equação de predição de peso fetal. A acurácia desta nova fórmula foi comparada com as fórmulas bidimensionais de Shepard e Hadlock. RESULTADOS: o volume do braço fetal foi altamente correlacionado com o peso ao nascimento (r=0,83; p0,05. Em relação à fórmula de Hadlock, apenas o erro médio foi menor, mas não estatisticamente significante (p>0,05. CONCLUSÕES: o volume do braço fetal aferido pela USG3D mostrou acurácia similar às fórmulas bidimensionais na predição do peso ao nascimento. Há necessidade de estudos com maiores casuísticas para se comprovar esses achados.PURPOSE: to evaluate the accuracy of fetal upper arm volume, using three-dimensional ultrasound (3DUS, in the prediction of birth weight. METHODS: this prospective cross-sectional study involved 25 pregnancies without structural or chromosomal anomalies. Bidimensional parameters (biparietal diameter, abdominal circumference and femur length and the 3DUS fetal upper arm volume were obtained in the last 48 hours before delivery. The multiplanar method, using multiple sequential planes with 5.0-mm intervals, was used to calculate fetal upper arm volume. Polynomial regressions were used to determine the best equation in the prediction of fetal weight. The accuracy of this new formula was

  9. CyberStorm III

    NARCIS (Netherlands)

    Luiijf, H.A.M.; et al

    2010-01-01

    Projectteam Cyber Storm III - De Verenigde Staten organiseerden de afgelopen jaren een reeks grootschalige ICT-crisisoefeningen met de naam Cyber Storm. Cyber Storm III is de derde oefening in de reeks. Het scenario van Cyber Storm III staat in het teken van grootschalige ICT-verstoringen, waarbij n

  10. Prediction of Supersonic Store Separation Characteristics Including Fuselage and Stores of Noncircular Cross Section, Volume IV. Appendices C and D, Details of Program II.

    Science.gov (United States)

    1980-11-01

    VOLUME IV - APPENDICES C AND D, DETAILS OF PROGRAM II Joseph Mullen, Jr. Frederick K. Goodwin Marnix F. E. Dillenius Nielsen Engineering & Research...location in store source panel coordinates of leading edge of wing, feet RAZ semi-axis in vertical direction of elliptic body, feet RBY semi-axis in

  11. Experimental and Theoretical Studies on Biologically Active Lanthanide (III) Complexes

    Science.gov (United States)

    Kostova, I.; Trendafilova, N.; Georgieva, I.; Rastogi, V. K.; Kiefer, W.

    2008-11-01

    The complexation ability and the binding mode of the ligand coumarin-3-carboxylic acid (HCCA) to La(III), Ce(III), Nd(III), Sm(III), Gd(III) and Dy(III) lanthanide ions (Ln(III)) are elucidated at experimental and theoretical level. The complexes were characterized using elemental analysis, DTA and TGA data as well as 1H NMR and 13C NMR spectra. FTIR and Raman spectroscopic techniques as well as DFT quantum chemical calculations were used for characterization of the binding mode and the structures of lanthanide(III) complexes of HCCA. The metal—ligand binding mode is predicted through molecular modeling and energy estimation of different Ln—CCA structures using B3LYP/6-31G(d) method combined with a large quasi-relativistic effective core potential for lanthanide ion. The energies obtained predict bidentate coordination of CCA- to Ln(III) ions through the carbonylic oxygen and the carboxylic oxygen. Detailed vibrational analysis of HCCA, CCA- and Ln(III) complexes based on both calculated and experimental frequencies confirms the suggested metal—ligand binding mode. The natural bonding analysis predicts strongly ionic character of the Ln(III)-CCA bonding in the- complexes studied. With the relatively resistant tumor cell line K-562 we obtained very interesting in-vitro results which are in accordance with our previously published data concerning the activity of lanthanide(III) complexes with other coumarin derivatives.

  12. New players in the same old game: a system level in silico study to predict type III secretion system and effector proteins in bacterial genomes reveals common themes in T3SS mediated pathogenesis.

    Science.gov (United States)

    Sadarangani, Vineet; Datta, Sunando; Arunachalam, Manonmani

    2013-07-26

    Type III secretion system (T3SS) plays an important role in virulence or symbiosis of many pathogenic or symbiotic bacteria [CHM 2:291-294, 2007; Physiology (Bethesda) 20:326-339, 2005]. T3SS acts like a tunnel between a bacterium and its host through which the bacterium injects 'effector' proteins into the latter [Nature 444:567-573, 2006; COSB 18:258-266, 2008]. The effectors spatially and temporally modify the host signalling pathways [FEMS Microbiol Rev 35:1100-1125, 2011; Cell Host Microbe5:571-579, 2009]. In spite its crucial role in host-pathogen interaction, the study of T3SS and the associated effectors has been limited to a few bacteria [Cell Microbiol 13:1858-1869, 2011; Nat Rev Microbiol 6:11-16, 2008; Mol Microbiol 80:1420-1438, 2011]. Before one set out to perform systematic experimental studies on an unknown set of bacteria it would be beneficial to identify the potential candidates by developing an in silico screening algorithm. A system level study would also be advantageous over traditional laboratory methods to extract an overriding theme for host-pathogen interaction, if any, from the vast resources of data generated by sequencing multiple bacterial genomes. We have developed an in silico protocol in which the most conserved set of T3SS proteins was used as the query against the entire bacterial database with increasingly stringent search parameters. It enabled us to identify several uncharacterized T3SS positive bacteria. We adopted a similar strategy to predict the presence of the already known effectors in the newly identified T3SS positive bacteria. The huge resources of biochemical data [FEMS Microbiol Rev 35:1100-1125, 2011; Cell Host Microbe 5:571-579, 2009; BMC Bioinformatics 7(11):S4, 2010] on the T3SS effectors enabled us to search for the common theme in T3SS mediated pathogenesis. We identified few cellular signalling networks in the host, which are manipulated by most of the T3SS containing pathogens. We went on to look for

  13. Global Positioning System III (GPS III)

    Science.gov (United States)

    2015-12-01

    Military Operations in Urban Terrain; Defense-Wide Mission Support; Air Mobility; and Space Launch Orbital Support. For military users, the GPS III...program provides Precise Positioning Service (PPS) to military operations and force enhancement. It also provides increased anti-jam power to the earth ...to be modified . On January 31, 2016, USD(AT&L) signed the GPS III revised APB. This Change 1 to the APB was due to both cost and schedule breaches

  14. Development of WAIS-III General Ability Index Minus WMS-III memory discrepancy scores.

    Science.gov (United States)

    Lange, Rael T; Chelune, Gordon J; Tulsky, David S

    2006-09-01

    Analysis of the discrepancy between intellectual functioning and memory ability has received some support as a useful means for evaluating memory impairment. In recent additions to Wechlser scale interpretation, the WAIS-III General Ability Index (GAI) and the WMS-III Delayed Memory Index (DMI) were developed. The purpose of this investigation is to develop base rate data for GAI-IMI, GAI-GMI, and GAI-DMI discrepancy scores using data from the WAIS-III/WMS-III standardization sample (weighted N = 1250). Base rate tables were developed using the predicted-difference method and two simple-difference methods (i.e., stratified and non-stratified). These tables provide valuable data for clinical reference purposes to determine the frequency of GAI-IMI, GAI-GMI, and GAI-DMI discrepancy scores in the WAIS-III/WMS-III standardization sample.

  15. Prediction of Long-term Post-operative Testosterone Replacement Requirement Based on the Pre-operative Tumor Volume and Testosterone Level in Pituitary Macroadenoma

    OpenAIRE

    Cheng-Chi Lee; Chung-Ming Chen; Shih-Tseng Lee; Kuo-Chen Wei; Ping-Ching Pai; Cheng-Hong Toh; Chi-Cheng Chuang

    2015-01-01

    Non-functioning pituitary macroadenomas (NFPAs) are the most prevalent pituitary macroadenomas. One common symptom of NFPA is hypogonadism, which may require long-term hormone replacement. This study was designed to clarify the association between the pre-operative tumor volume, pre-operative testosterone level, intraoperative resection status and the need of long-term post-operative testosterone replacement. Between 2004 and 2012, 45 male patients with NFPAs were enrolled in this prospective...

  16. Metallothionein (MT)-III

    DEFF Research Database (Denmark)

    Carrasco, J; Giralt, M; Molinero, A

    1999-01-01

    Metallothionein-III is a low molecular weight, heavy-metal binding protein expressed mainly in the central nervous system. First identified as a growth inhibitory factor (GIF) of rat cortical neurons in vitro, it has subsequently been shown to be a member of the metallothionein (MT) gene family...... and renamed as MT-III. In this study we have raised polyclonal antibodies in rabbits against recombinant rat MT-III (rMT-III). The sera obtained reacted specifically against recombinant zinc-and cadmium-saturated rMT-III, and did not cross-react with native rat MT-I and MT-II purified from the liver of zinc...... injected rats. The specificity of the antibody was also demonstrated in immunocytochemical studies by the elimination of the immunostaining by preincubation of the antibody with brain (but not liver) extracts, and by the results obtained in MT-III null mice. The antibody was used to characterize...

  17. Nuclear volume and prognosis in ovarian cancer

    DEFF Research Database (Denmark)

    Mogensen, O.; Sørensen, Flemming Brandt; Bichel, P.

    1992-01-01

    The prognostic value of the volume-weighted mean nuclear volume (MNV) was investigated retrospectively in 100 ovarian cancer patients with FIGO-stage IB-II (n = 51) and stage III-IV (n = 49) serous tumors. No association was demonstrated between the MNV and the survival or between the MNV and two...

  18. Nuclear volume and prognosis in ovarian cancer

    DEFF Research Database (Denmark)

    Mogensen, O.; Sørensen, Flemming Brandt; Bichel, P.;

    1992-01-01

    The prognostic value of the volume-weighted mean nuclear volume (MNV) was investigated retrospectively in 100 ovarian cancer patients with FIGO-stage IB-II (n = 51) and stage III-IV (n = 49) serous tumors. No association was demonstrated between the MNV and the survival or between the MNV and two...

  19. Change in volume parameters induced by neoadjuvant chemotherapy provide accurate prediction of overall survival after resection in patients with oesophageal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Tamandl, Dietmar; Fueger, Barbara; Kinsperger, Patrick; Haug, Alexander; Ba-Ssalamah, Ahmed [Medical University of Vienna, Department of Biomedical Imaging and Image-Guided Therapy, Comprehensive Cancer Center GET-Unit, Vienna (Austria); Gore, Richard M. [University of Chicago Pritzker School of Medicine, Department of Radiology, Chicago, IL (United States); Hejna, Michael [Medical University of Vienna, Department of Internal Medicine, Division of Medical Oncology, Comprehensive Cancer Center GET-Unit, Vienna (Austria); Paireder, Matthias; Schoppmann, Sebastian F. [Medical University of Vienna, Department of Surgery, Upper-GI-Service, Comprehensive Cancer Center GET-Unit, Vienna (Austria)

    2016-02-15

    To assess the prognostic value of volumetric parameters measured with CT and PET/CT in patients with neoadjuvant chemotherapy (NACT) and resection for oesophageal cancer (EC). Patients with locally advanced EC, who were treated with NACT and resection, were retrospectively analysed. Data from CT volumetry and {sup 18} F-FDG PET/CT (maximum standardized uptake [SUVmax], metabolic tumour volume [MTV], and total lesion glycolysis [TLG]) were recorded before and after NACT. The impact of volumetric parameter changes induced by NACT (MTV{sub RATIO}, TLG{sub RATIO}, etc.) on overall survival (OS) was assessed using a Cox proportional hazards model. Eighty-four patients were assessed using CT volumetry; of those, 50 also had PET/CT before and after NACT. Low post-treatment CT volume and thickness, MTV, TLG, and SUVmax were all associated with longer OS (p < 0.05), as were CTthickness{sub RATIO}, MTV{sub RATIO}, TLG{sub RATIO}, and SUVmax{sub RATIO} (p < 0.05). In the multivariate analysis, only MTV{sub RATIO} (Hazard ratio, HR 2.52 [95 % Confidence interval, CI 1.33-4.78], p = 0.005), TLG{sub RATIO} (HR 3.89 [95%CI 1.46-10.34], p = 0.006), and surgical margin status (p < 0.05), were independent predictors of OS. MTV{sub RATIO} and TLG{sub RATIO} are independent prognostic factors for survival in patients after NACT and resection for EC. (orig.)

  20. Volume-Based Parameters of {sup 18}F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Improve Disease Recurrence Prediction in Postmastectomy Breast Cancer Patients With 1 to 3 Positive Axillary Lymph Nodes

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, Naomi, E-mail: haruhi0321@gmail.com [Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Department of Radiology, Ehime University, Ehime (Japan); Kataoka, Masaaki [Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Sugawara, Yoshifumi [Department of Diagnostic Radiology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Ochi, Takashi [Department of Radiology, Ehime University, Ehime (Japan); Kiyoto, Sachiko; Ohsumi, Shozo [Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Mochizuki, Teruhito [Department of Radiology, Ehime University, Ehime (Japan)

    2013-11-15

    Purpose: To determine whether volume-based parameters on pretreatment {sup 18}F-fluorodeoxyglucose positron emission tomography/computed tomography in breast cancer patients treated with mastectomy without adjuvant radiation therapy are predictive of recurrence. Methods and Materials: We retrospectively analyzed 93 patients with 1 to 3 positive axillary nodes after surgery, who were studied with {sup 18}F-fluorodeoxyglucose positron emission tomography/computed tomography for initial staging. We evaluated the relationship between positron emission tomography parameters, including the maximum standardized uptake value, metabolic tumor volume (MTV), and total lesion glycolysis (TLG), and clinical outcomes. Results: The median follow-up duration was 45 months. Recurrence was observed in 11 patients. Metabolic tumor volume and TLG were significantly related to tumor size, number of involved nodes, nodal ratio, nuclear grade, estrogen receptor (ER) status, and triple negativity (TN) (all P values were <.05). In receiver operating characteristic curve analysis, MTV and TLG showed better predictive performance than tumor size, ER status, or TN (area under the curve: 0.85, 0.86, 0.79, 0.74, and 0.74, respectively). On multivariate analysis, MTV was an independent prognostic factor of locoregional recurrence-free survival (hazard ratio 34.42, 95% confidence interval 3.94-882.71, P=.0008) and disease-free survival (DFS) (hazard ratio 13.92, 95% confidence interval 2.65-103.78, P=.0018). The 3-year DFS rate was 93.8% for the lower MTV group (<53.1; n=85) and 25.0% for the higher MTV group (≥53.1; n=8; P<.0001, log–rank test). The 3-year DFS rate for patients with both ER-positive status and MTV <53.1 was 98.2%; and for those with ER-negative status and MTV ≥53.1 it was 25.0% (P<.0001). Conclusions: Volume-based parameters improve recurrence prediction in postmastectomy breast cancer patients with 1 to 3 positive nodes. The addition of MTV to ER status or TN has

  1. Measurement of binding of basic drugs to acidic phospholipids using surface plasmon resonance and incorporation of the data into mechanistic tissue composition equations to predict steady-state volume of distribution.

    Science.gov (United States)

    Small, Helen; Gardner, Iain; Jones, Hannah M; Davis, John; Rowland, Malcolm

    2011-10-01

    Acidic phospholipid binding plays an important role in determining the tissue distribution of basic drugs. This article describes the use of surface plasmon resonance to measure binding affinity (K(D)) of three basic drugs to phosphatidylserine, a major tissue acidic phospholipid. The data are incorporated into mechanistic tissue composition equations to allow prediction of the steady-state volume of distribution (V(ss)). The prediction accuracy of V(ss) using this approach is compared with the original methodology described by Rodgers et al. (J Pharm Sci 94:1259-1276), in which the binding to acidic phospholipids is calculated from the blood/plasma concentration ratio (BPR). The compounds used in this study [amlodipine, propranolol, and 3-dimethylaminomethyl-4-(4-methylsulfanyl-phenoxy)-benzenesulfonamide (UK-390957)] showed higher affinity binding to phosphatidylserine than to phosphatidylcholine. When the binding affinity to phosphatidylserine was incorporated into mechanistic tissue composition equations, the V(ss) was more accurately predicted for all three compounds by using the surface plasmon resonance measurement than by using the BPR to estimate acidic phospholipid binding affinity. The difference was particularly marked for UK-390957, a sulfonamide that has a high BPR due to binding to carbonic anhydrase. The novel approach described in this article allows the binding affinity of drugs to an acidic phospholipid (phosphatidylserine) to be measured directly and demonstrates the utility of the binding data in the prediction of V(ss).

  2. Industrial fuel gas demonstration plant program. Current working estimate. Phase III and III

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    The United States Department of Energy (DOE) executed a contract with Memphis Light, Gas and Water Division (MLGW) which requires MLGW to perform process analysis, design, procurement, construction, testing, operation, and evaluation of a plant which will demonstrate the feasibility of converting high sulfur bituminous coal to industrial fuel gas with a heating value of 300 +- 30 Btu per standard cubic foot (SCF). The demonstration plant is based on the U-Gas process, and its product gas is to be used in commercial applications in Memphis, Tenn. The contract specifies that the work is to be conducted in three phases. The Phases are: Phase I - Program Development and Conceptual Design; Phase II - Demonstration Plant Final Design, Procurement and Construction; and Phase III - Demonstration Plant Operation. Under Task III of Phase I, a Cost Estimate for the Demonstration Plant was completed as well as estimates for other Phase II and III work. The output of this Estimate is presented in this volume. This Current Working Estimate for Phases II and III is based on the Process and Mechanical Designs presented in the Task II report (second issue) and the 12 volumes of the Task III report. In addition, the capital cost estimate summarized in the appendix has been used in the Economic Analysis (Task III) Report.

  3. White River Falls Fish Passage Project, Tygh Valley, Oregon : Final Technical Report, Volume III, Appendix B, Fisheries Report; Appendix C, Engineering Alternative Evaluation; Appendix D, Benefit/Cost Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Oregon. Dept. of Fish and Wildlife; Mount Hood National Forest (Or.)

    1985-06-01

    Studies were conducted to describe current habitat conditions in the White River basin above White River Falls and to evaluate the potential to produce anadromous fish. An inventory of spawning and rearing habitats, irrigation diversions, and enhancement opportunities for anadromous fish in the White River drainage was conducted. Survival of juvenile fish at White River Falls was estimated by releasing juvenile chinook and steelhead above the falls during high and low flow periods and recapturing them below the falls in 1983 and 1984. Four alternatives to provide upstream passage for adult salmon and steelhead were developd to a predesign level. The cost of adult passage and the estimated run size of anadromous fish were used to determine the benefit/cost of the preferred alternative. Possible effects of the introduction of anadromous fish on resident fish and on nearby Oak Springs Hatchery were evaluated. This included an inventory of resident species, a genetic study of native rainbow, and the identification of fish diseases in the basin. This volume contains appendices of habitat survey data, potential production, resident fish population data, upstream passage designs, and benefit/cost calculations. (ACR)

  4. The role of stroke volume variation in predicting the volume responsiveness of patients with severe sepsis and septic shock%每搏量变异度预测严重感染和感染性休克患者容量反应性的价值

    Institute of Scientific and Technical Information of China (English)

    黄磊; 张卫星; 蔡文训; 罗华; 陈映群; 张声

    2010-01-01

    目的 研究每搏量变异度(stroke volume variation,SW)预测严重感染和感染性休克机械通气患者容量反应性的价值.方法 前瞻观察性研究,对2009年1月至2010年3月北京大学深圳医院ICU严重感染和感染性休克机械通气患者28例进行容量负荷试验.超声心输出量监测仪无创监测心脏指数(cardiac index,CI)、每搏输出量指数(stroke volume index,SVI)、外周血管阻力(systemic vascular resistance,SVR)、SVV等血流动力学指标.根据容量负荷试验前后CI增加值是否大于12%分为有反应组和无反应组,组间比较应用两独立样本t检验;容量负荷试验前后比较应用配对t检验;受试者工作特征曲线评价SVV、中心静脉压(central venous pressure,CVP)以及容量负荷试验前后CVP变化值(△CVP)预测容量反应性的价值.结果 容量负荷试验前,有反应组SW高于无反应组[(18.2±4.7)%和(12.7±4.2)%,P=0.003];而CVP两组差异无统计学意义[(10.2±4.0)cmH2O和(10.8±4.8)cmH2O,P>0.05].容量负荷试验后,有反应组△CVP低于无反应组[(2.9±3.1)cmH2O和(5.3±2.7)cmH2O,P=0.037].SVV、CVP和△CVP的曲线下面积(AUC)分别是0.836(95%CI:0.680~0.992,P=0.003)、0.549(95%CI:0.329~0.768,P=0.662)和0.762(95%CI:0.570~0.953,P=0.019).SVV为15.5%时预测容量反应性的敏感度和特异度分别是84.6%和80%.结论 SVV预测严重感染和感染性休克机械通气患者的容量反应性具有良好价值,明显优于CVP、△CVP等传统指标.%Objective To assess the role of stroke volume variation (SVV) in predicting the volume responsiveness of mechanically ventilated patients with severe sepsis and septic shock. Method A total of 28 mechanically ventilated patients with severe sepsis and septic shock were admitted from January 2009 to March 2010. Every patient was treated with volume loading test. Cardiac index (CI), stroke volume index (SVI), systemic vascular resistance (SVR) and SVV were measured non-invasively by

  5. A finite-volume fast diffusion-limited aggregation model for predicting the coagulation rate of mixed low-ionized system

    Science.gov (United States)

    Feng, Yu; Wang, Guang; Ruan, Leidan; Du, Ai

    2017-03-01

    Accompanied with the changing of coagulation time, the micro-structure of aerogel can be controlled by adding Polyacrylic acid (PAA) into sol system. We simulate the process of particles aggregation contains attracting molecular chains based on diffusion-limited cluster aggregation (DLCA). Compared with the normal coagulation system, the coagulation rate of the system that contains attracting chains are sped up first and then slowed down. The results of the stimulation point out that the interaction between particles and chains not only accelerates the motion of particles, but also separates the region and constrains the clusters' motion. These two effects are coexisting but the attracting interaction play a dominant role in the early state while the volume of chains has a dramatic influence on cluster's motion in late states.

  6. Prognostic value of metabolic tumor volume on {sup 11}C-methionine PET in predicting progression-free survival in high-grade glioma

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Min Young; Paeng, Jin Chul; Cheon, Gi Jeong; Lee, Dong Soo; Chung, June Key; Kang, Keon Wook [Dept. of Nuclear Medicine, Seoul National University Hospital, Seoul (Korea, Republic of); Kim, E. Edmund [Dept. of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul (Korea, Republic of)

    2015-12-15

    C-11 methionine (MET) PET is commonly used for diagnosing high-grade glioma (HGG). Recently, volumetric analysis has been widely applied to oncologic PET imaging. In this study, we investigated the prognostic value of metabolic tumor volume (MTV) on MET PET in HGG. A total of 30 patients with anaplastic astrocytoma (n = 12) and glioblastoma multiforme (n = 18) who underwent MET PET before treatment (surgery followed by chemo-radiotherapy) were retrospectively enrolled. Maximal tumor-to-normal brain ratio (TNR{sub max}, maximum tumor activity divided by mean of normal tissue) and MTV (volume of tumor tissue that shows uptake >1.3-fold of mean uptake in normal tissue) were measured on MET PET. Adult patients were classified into two subgroups according to Radiation Therapy Oncology Group Recursive Partitioning Analysis (RTOG RPA) classification. Prognostic values of TNR{sub max}, MTV and clinicopathologic factors were evaluated with regard to progression-free survival (PFS). Median PFS of all patients was 7.9 months (range 1.0–53.8 months). In univariate analysis, MTV (cutoff 35 cm{sup 3}) was a significant prognostic factor for PFS (P = 0.01), whereas TNR{sub max} (cutoff 3.3) and RTOG RPA class were not (P = 0.80 and 0.61, respectively). Treatment of surgical resection exhibited a borderline significance (P = 0.06). In multivariate analysis, MTV was the only independent prognostic factor for PFS (P = 0.03). MTV on MET PET is a significant and independent prognostic factor for PFS in HGG patients, whereas TNR{sub max} is not. Thus, performing volumetric analysis of MET PET is recommended in HGG for better prognostication.

  7. Forced expiratory volume in one second predicts length of stay and in-hospital mortality in patients undergoing cardiac surgery: a retrospective cohort study.

    Directory of Open Access Journals (Sweden)

    David A McAllister

    Full Text Available OBJECTIVE: An aging population and increasing use of percutaneous therapies have resulted in older patients with more co-morbidity being referred for cardiac surgery. Objective measurements of physiological reserve and severity of co-morbid disease are required to improve risk stratification. We hypothesised that FEV1 would predict mortality and length of stay following cardiac surgery. METHODS: We assessed clinical outcomes in 2,241 consecutive patients undergoing coronary artery bypass grafting and/or valve surgery from 2001 to 2007 in a regional cardiac centre. Generalized linear models of the association between FEV1 and length of hospital stay and mortality were adjusted for age, sex, height, body mass index, socioeconomic status, smoking, cardiovascular risk factors, long-term use of bronchodilators or steroids for lung disease, and type and urgency of surgery. FEV1 was compared to an established risk prediction model, the EuroSCORE. RESULTS: Spirometry was performed in 2,082 patients (93% whose mean (SD age was 67 (10 years. Median hospital stay was 3 days longer in patients in the lowest compared to the highest quintile for FEV1, 1.35-fold higher (95% CI 1.20-1.52; p<0.001. The adjusted odds ratio for mortality was increased 2.11-fold (95% CI 1.45-3.08; p<0.001 per standard deviation decrement in FEV1 (800 ml. FEV1 improved discrimination of the EuroSCORE for mortality. Similar associations were found after excluding people with known pulmonary disease and/or airflow limitation on spirometry. CONCLUSIONS: Reduced FEV1 strongly predicted increased length of stay and in-hospital mortality following cardiac surgery. FEV1 is a widely available measure of physiological health that may improve risk stratification of complex patients undergoing cardiac surgery and should be evaluated for inclusion in new prediction tools.

  8. Biomarkers of Exposure to Toxic Substances. Volume 1. Global Experimental Design: Biomarker Discovery for Early Prediction of Organ-Selective Toxicity

    Science.gov (United States)

    2009-05-30

    formation of proteinaceous casts in the proximal tubules (Ryan, 1986). Puromycin- induced nephrosis in rats provides a useful model for studying the...Liquid chromatography-mass spectrometric analysis of urinary metabolites and their pattern recognition for the prediction of drug- induced hepatotoxicity ...Uribe M, Romero L, and Peña JC, “Pathophysiology of experimental nephrotic syndrome induced by puromycin aminonucleoside in rats . I. The role of

  9. Evaluation and Prediction of Henry’s Law Constants and Aqueous Solubilities for Solvents and Hydrocarbon Fuel Components. Volume 2. Experimental Henry’s Law Data

    Science.gov (United States)

    1987-09-01

    Redlich - Kwong Equation of State," J. Eng. Sci., Vol. 27:1197-1203. 1972. Staverman, A. J., ’.The Entropy of High Polymer Solutions. Generalization of...NAME OF PERFORMING ORGANIZATION 6b. OFFICE SYMBOL 7a. NAME OF MONITORING ORGANIZATION (If applicable ) Research Triangle Institute HQ AFESC/RDVW 6c...page 61). The techniques were examined.to determine their applicability to environmental systems and their predictive capacity for unmeasured

  10. Computation of methodology-independent single-ion solvation properties from molecular simulations. III. Correction terms for the solvation free energies, enthalpies, entropies, heat capacities, volumes, compressibilities, and expansivities of solvated ions.

    Science.gov (United States)

    Reif, Maria M; Hünenberger, Philippe H

    2011-04-14

    The raw single-ion solvation free energies computed from atomistic (explicit-solvent) simulations are extremely sensitive to the boundary conditions (finite or periodic system, system or box size) and treatment of electrostatic interactions (Coulombic, lattice-sum, or cutoff-based) used during these simulations. However, as shown by Kastenholz and Hünenberger [J. Chem. Phys. 124, 224501 (2006)], correction terms can be derived for the effects of: (A) an incorrect solvent polarization around the ion and an incomplete or/and inexact interaction of the ion with the polarized solvent due to the use of an approximate (not strictly Coulombic) electrostatic scheme; (B) the finite-size or artificial periodicity of the simulated system; (C) an improper summation scheme to evaluate the potential at the ion site, and the possible presence of a polarized air-liquid interface or of a constraint of vanishing average electrostatic potential in the simulated system; and (D) an inaccurate dielectric permittivity of the employed solvent model. Comparison with standard experimental data also requires the inclusion of appropriate cavity-formation and standard-state correction terms. In the present study, this correction scheme is extended by: (i) providing simple approximate analytical expressions (empirically-fitted) for the correction terms that were evaluated numerically in the above scheme (continuum-electrostatics calculations); (ii) providing correction terms for derivative thermodynamic single-ion solvation properties (and corresponding partial molar variables in solution), namely, the enthalpy, entropy, isobaric heat capacity, volume, isothermal compressibility, and isobaric expansivity (including appropriate standard-state correction terms). The ability of the correction scheme to produce methodology-independent single-ion solvation free energies based on atomistic simulations is tested in the case of Na(+) hydration, and the nature and magnitude of the correction terms for

  11. Silicon materials task of the low cost solar array project (Phase III). Effect of impurities and processing on silicon solar cells. Phase III summary and seventeenth quarterly report, Volume 1: characterization methods for impurities in silicon and impurity effects data base

    Energy Technology Data Exchange (ETDEWEB)

    Hopkins, R.H.; Davis, J.R.; Rohatgi, A.; Campbell, R.B.; Blais, P.D.; Rai-Choudhury, P.; Stapleton, R.E.; Mollenkopf, H.C.; McCormick, J.R.

    1980-01-01

    The object of Phase III of the program has been to investigate the effects of various processes, metal contaminants and contaminant-process interactions on the performance of terrestrial silicon solar cells. The study encompassed a variety of tasks including: (1) a detailed examination of thermal processing effects, such as HCl and POCl/sub 3/ gettering on impurity behavior, (2) completion of the data base and modeling for impurities in n-base silicon, (3) extension of the data base on p-type material to include elements likely to be introduced during the production, refining, or crystal growth of silicon, (4) effects on cell performance on anisotropic impurity distributions in large CZ crystals and silicon webs, and (5) a preliminary assessment of the permanence of the impurity effects. Two major topics are treated: methods to measure and evaluate impurity effects in silicon and comprehensive tabulations of data derived during the study. For example, discussions of deep level spectroscopy, detailed dark I-V measurements, recombination lifetime determination, scanned laser photo-response, and conventional solar cell I-V techniques, as well as descriptions of silicon chemical analysis are included. Considerable data are tabulated on the composition, electrical, and solar cell characteristics of impurity-doped silicon.

  12. Research in collegiate mathematics education III

    CERN Document Server

    Arcavi, A; Kaput, Jim; Dubinsky, Ed; Dick, Thomas

    1998-01-01

    Volume III of Research in Collegiate Mathematics Education (RCME) presents state-of-the-art research on understanding, teaching, and learning mathematics at the post-secondary level. This volume contains information on methodology and research concentrating on these areas of student learning: Problem solving. Included here are three different articles analyzing aspects of Schoenfeld's undergraduate problem-solving instruction. The articles provide new detail and insight on a well-known and widely discussed course taught by Schoenfeld for many years. Understanding concepts. These articles fe

  13. Medida da freqüência respiratória e do volume corrente para prever a falha na extubação de recém-nascidos de muito baixo peso em ventilação mecânica Evaluation of respiratory rate and tidal volume to predict extubation failure in mechanically ventilated very low birth weight infants

    Directory of Open Access Journals (Sweden)

    Josy Davidson

    2008-03-01

    Full Text Available OBJETIVO: Verificar se a freqüência respiratória (FR, o volume corrente (VC e a relação FR/VC poderiam prever a falha na extubação em recém-nascidos de muito baixo peso submetidos à ventilação mecânica. MÉTODOS: Estudo prospectivo, observacional, de recém-nascidos com idade gestacional OBJECTIVE: To verify if respiratory rate (RR, tidal volume (TV and respiratory rate and tidal volume ratio (RR/TV could predict extubation failure in very low birth weight infants submitted to mechanical ventilation. METHODS: This prospective observational study enrolled newborn infants with gestational age <37 weeks and birth weight <1,500g, mechanically ventilated from birth during 48 hours to 30 days and thought to be ready for extubation. As soon as the physicians decided for extubation, the neonates received endotracheal continuous positive airway pressure (CPAP for 10 minutes while spontaneous RR, TV and RR/TV were measured using a fixed-orifice pneumotachograph positioned between the endotracheal tube and the ventilator circuit. Thereafter, the neonates were extubated to nasal CPAP. Extubation failure was defined as the need for reintubation within 48 hours. RESULTS: Of the 35 studied infants, 20 (57% were successfully extubated and 15 (43% required reintubation. RR and RR/TV before extubation had a trend to be higher in unsuccessfully extubated infants. TV was similar in both groups. Sensitivity and specificity of these parameters as predictors of extubation failure were 50 and 67% respectively for RR, 40 and 67% for TV and 40 and 73% for RR/TV. CONCLUSIONS: RR, TV and RR/TV showed low sensitivity and specificity to predict extubation failure in mechanically ventilated very low birth weight infants.

  14. Semiconductors. Subvol. A. New data and updates for I-VII, III-V, III-VI and IV-VI compounds

    Energy Technology Data Exchange (ETDEWEB)

    Roessler, U (ed.) [Regensburg Univ. (Germany). Inst. fuer Theoretische Physik; Dietl, T.; Dobrowolski, W.; Story, T. [Polish Academy of Sciences, Warszawa (Poland). Lab. for Cryogenic and Spintronic Research; Fernandes da Silva, E.C. [Universidade de Sao Paulo, SP (Brazil). Lab. de Novos Materiais Semiconductores; Hoenerlage, B. [IPCMS/GONLO, 67 - Strasbourg (France); Meyer, B.K. [Giessen Univ. (Germany). 1. Physikalisches Inst.

    2008-07-01

    The Landolt-Boernstein subvolumes III/44A and III/44B update the existing 8 volumes III/41 about Semiconductors and contain new Data and Updates for I-VII, III-V, III-VI, IV, VI and II-VI Compounds. The text, tables figures and references are provided in self-contained document files, each one dedicated to a substance and property. The first subvolume III/44A contains a ''Systematics of Semiconductor Properties'', which should help the non-specialist user to understand the meaning of the material parameters. Hyperlinked lists of substances and properties lead directly to the documents and make the electronic version an easy-to-use source of semiconductor data. In the new updates III/44A and III/44B, links to existing material in III/41 or to related documents for a specific substance are also included. (orig.)

  15. Report on the draft of the law No. 1253 concerning the Revamping and Expanding Domestic Electricity Supply. Volume III. Appendices and Table of abbreviations; Rapport sur le projet de loi (no. 1253) relatif a la modernisation et au developpement du service public de l'electricite. Tome III. Annexes et Table des sigles

    Energy Technology Data Exchange (ETDEWEB)

    Bataille, Christian [Assemblee Nationale, Paris (France)

    1999-02-11

    The third volume of the Report on behalf of the Production and Exchange Commission on the draft of the law No. 1253 concerning the Revamping and Expanding Domestic Electricity Supply contains Appendices. The appendix number 1 presents the directive 96/92 CE of the European Parliament and Council of 19 December 1996, concerning common rules referring to the electricity internal market. It contains the chapters titled: 1. Field of application and definitions; 2. General rules for sector organization; 3. Production; 4. Exploitation of the transport grid; 5. Exploitation of the distribution grid; 6. Accounting dissociation and transparency; 7. Organization of the grid access; 8. Final dispositions. The appendix number 2 gives the law no. 46 - 628 of 8 April, modified, on the nationalization of the electricity and gas. The third appendix reproduces Decree no. 55 - 662 of 20 May 1955 concerning relationships between the establishments aimed by the articles 2 and 23 of the law of 8 April 1946 and the autonomous producers of electric energy. The appendix number 4 contains the notification of State Council of 7 July 1994 regarding the diversification of EDF and GDF activities. The fifth appendix is a chronological list of the European negotiations concerning the opening of the electricity market (1987 -1997). Finally, a list of following abbreviations is given: ART, ATR, CNES, CRE, CTE, DNN, FACE, FPE, GRT, IEG, INB, PPI, RAG and SICAE.

  16. Cervical gross tumor volume dose predicts local control using magnetic resonance imaging/diffusion-weighted imaging-guided high-dose-rate and positron emission tomography/computed tomography-guided intensity modulated radiation therapy.

    Science.gov (United States)

    Dyk, Pawel; Jiang, Naomi; Sun, Baozhou; DeWees, Todd A; Fowler, Kathryn J; Narra, Vamsi; Garcia-Ramirez, Jose L; Schwarz, Julie K; Grigsby, Perry W

    2014-11-15

    Magnetic resonance imaging/diffusion weighted-imaging (MRI/DWI)-guided high-dose-rate (HDR) brachytherapy and (18)F-fluorodeoxyglucose (FDG) - positron emission tomography/computed tomography (PET/CT)-guided intensity modulated radiation therapy (IMRT) for the definitive treatment of cervical cancer is a novel treatment technique. The purpose of this study was to report our analysis of dose-volume parameters predicting gross tumor volume (GTV) control. We analyzed the records of 134 patients with International Federation of Gynecology and Obstetrics stages IB1-IVB cervical cancer treated with combined MRI-guided HDR and IMRT from July 2009 to July 2011. IMRT was targeted to the metabolic tumor volume and lymph nodes by use of FDG-PET/CT simulation. The GTV for each HDR fraction was delineated by use of T2-weighted or apparent diffusion coefficient maps from diffusion-weighted sequences. The D100, D90, and Dmean delivered to the GTV from HDR and IMRT were summed to EQD2. One hundred twenty-five patients received all irradiation treatment as planned, and 9 did not complete treatment. All 134 patients are included in this analysis. Treatment failure in the cervix occurred in 24 patients (18.0%). Patients with cervix failures had a lower D100, D90, and Dmean than those who did not experience failure in the cervix. The respective doses to the GTV were 41, 58, and 136 Gy for failures compared with 67, 99, and 236 Gy for those who did not experience failure (PD100, D90, and Dmean doses required for ≥90% local control to be 69, 98, and 260 Gy (P<.001). Total dose delivered to the GTV from combined MRI-guided HDR and PET/CT-guided IMRT is highly correlated with local tumor control. The findings can be directly applied in the clinic for dose adaptation to maximize local control. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. The type III manufactory

    CERN Document Server

    Palcoux, Sébastien

    2011-01-01

    Using unusual objects in the theory of von Neumann algebra, as the chinese game Go or the Conway game of life (generalized on finitely presented groups), we are able to build, by hands, many type III factors.

  18. 被动抬腿试验评估感染性休克患者容量反应性的临床研究%Clinical Study of Passive Leg Raising Trial to Predict Volume Responsiveness in Septic Shock

    Institute of Scientific and Technical Information of China (English)

    郭志利; 王勇强

    2015-01-01

    目的:评价被动抬腿试验(PLR)预测感染性休克患者的容量反应性。方法:采用前瞻性、观察性队列研究设计方法,选择34例感染性休克患者,先后进行 PLR 和容量负荷试验(VE),分别在 PLR 前(基线)、PLR 期间和 VE 后用超声心动图(TTE)测量记录每搏量(SV)并记录血流动力学变化。根据对容量负荷试验的反应(以 VE 后 SV 增加≥15%定义为有容量反应性)将患者分为有反应组和无反应组。用受试者工作特征曲线(ROC 曲线)评价 PLR 预测感染性休克患者的容量反应性。结果:34例患者中有反应组16例,无反应组18例。 VE 和 PLR 引起的ΔSV 存在显著直线相关性,Person 相关系数为0.630,P=0.000;PLR 诱导的ΔSV 预测感染性休克患者的容量反应性 ROC 曲线下面积(AUC)为0.866±0.064[95%可信区间(CI)为0.741~0.992,P=0.000],在 PLR 期间ΔSV 为11.84%时诊断容量反应性的敏感度为93.8%,特异度为72.2%。结论:PLR 在预测感染性休克患者的容量反应性具有良好的价值。%Objective :To investigate the ability of passive leg raising (PLR) trial predicting volume responsiveness in septic shock .Methods :The prospective and observational cohort study was performed in 34 septic shock patients .PLR and volume expansion(VE) has been carried out successively .Respectively ,in front of the PLR (baseline) ,during the period of PLR and after VE using echocardiography measure stroke volume (SV) and hemodynamic changes in the re‐cord .According to the responsiveness of volume expansion (Responders were defined by the appearance of an increase in SV ≥ 15% after VE) ,patients were divided into responders and non‐responders .Using the receiver operating char‐acteristic curve (ROC curve) analysis PLR assessment of volume responsiveness in patients with septic shock .Results :A total of 34 patients were

  19. Silver(II) Oxide or Silver(I,III) Oxide?

    Science.gov (United States)

    Tudela, David

    2008-01-01

    The often called silver peroxide and silver(II) oxide, AgO or Ag[subscript 2]O[subscript 2], is actually a mixed oxidation state silver(I,III) oxide. A thermochemical cycle, with lattice energies calculated within the "volume-based" thermodynamic approach, explain why the silver(I,III) oxide is more stable than the hypothetical silver(II) oxide.…

  20. Predição da degradação da matéria seca pelo volume de gases utilizando a técnica in vitro semi-automática de produção de gases Prediction of dry matter degradation from volume of gas production using the in vitro semi-automatic gas production technique

    Directory of Open Access Journals (Sweden)

    Ú.T. Nogueira

    2006-10-01

    Full Text Available Estimou-se a degradação da matéria seca (DMS via produção de gases (PG por meio de equações. Foram agrupados dados de volume de gases e DMS de oito forrageiras (Brachiaria brizantha, Brachiaria decumbens, feno de Cynodon spp, silagem de milho, silagem de milheto, sorgo de corte, capim-elefante e cana-de-açúcar e de milho em grão. Os dados de DMS obtidos em laboratório foram comparados à DMS obtida pelas equações de regressão. Apesar dos altos coeficientes de determinação, os resultados demonstraram a impossibilidade de estimar a DMS via PG pelas equações geral, de dois e de três pontos.The dry matter degration (DMD was estimated through volume of gas produced (GP during the in vitro fermentation. The DMD from eight forages (Brachiaria brizantha, Brachiaria decumbens, cynodon hay, maize silage, Pennisetum glaucon, sorghum, elephant grass and sugarcane and corn grain were obtained and were compared with the DMD estimated using regression equations. The results showed the GP can not predict the DMD due to inocula effects, chemical composition of substrate or losses of particles of soluble material during filtration process.

  1. Performance characteristics of postacute traumatic brain injury patients on the WAIS-III and WMS-III.

    Science.gov (United States)

    Axelrod, B N; Fichtenberg, N L; Liethen, P C; Czarnota, M A; Stucky, K

    2001-12-01

    Publication of the third editions of the Wechsler intelligence and memory batteries in 1997 created a need for research identifying Wechsler Adult Intelligence Scale-Third Edition/Wechsler Memory Scale-Third Edition (WAIS-III/WMS-III) profile patterns associated with neuropathology. The WAIS-III/WMS-III Technical Manual offers data on various diagnostic groups, including traumatic brain injury (TBI). Hawkins (1998) employed Technical Manual data to propose certain diagnostic guidelines. In order to validate the conclusions put forth by Hawkins as they apply to brain injury, we examined WAIS-III and WMS-III profiles in an independent sample of 46 TBI cases. As expected, the WAIS-III Processing Speed Index (PSI) was more sensitive to brain injury than other WAIS-III composites; and specific WAIS-III scores were stronger than certain WMS-III scores. On the other hand, the predicted relationship for WMS-III auditory and visual indexes was not found. The lack of specificity for TBI of the proposed index comparisons confirms the need to validate such hypotheses in independent samples.

  2. Meaningful Thresholds for the Volume-Outcome Relationship in Total Knee Arthroplasty.

    Science.gov (United States)

    Wilson, Sean; Marx, Robert G; Pan, Ting-Jung; Lyman, Stephen

    2016-10-19

    Increasing evidence supports the finding that patients undergoing a total knee arthroplasty with high-volume physicians and hospitals achieve better outcomes. Unfortunately, the existing definitions for high-volume surgeons and hospitals are highly variable and entirely arbitrary. The aim of this study was to identify a set of meaningful hospital and surgeon total knee arthroplasty volume thresholds. Using 289,976 patients undergoing primary total knee arthroplasty from an administrative database, we applied stratum-specific likelihood ratio (SSLR) analysis of a receiver operating characteristic (ROC) curve to generate sets of volume thresholds most predictive of adverse outcomes. The outcomes considered for surgeon volume included 90-day complication and 2-year revision. For hospital volume, we considered 90-day complications and 90-day mortality. SSLR analysis of the ROC curves for 90-day complication and 2-year revision rates by surgeon volume identified four volume categories: 0 to 12, 13 to 59, 60 to 145, and ≥146 total knee arthroplasties per year. Complication rates decreased significantly (p < 0.05) in progressively higher-volume categories. Revision rates followed a similar pattern, but did not decrease between surgeons performing 60 to 145 arthroplasties per year and those performing ≥146 arthroplasties per year. SSLR analysis of 90-day complication and 90-day mortality rates by hospital volume also identified four volume categories: 0 to 89, 90 to 235, 236 to 644, and ≥645 total knee arthroplasties per year. Complication rates decreased significantly (p < 0.05) in progressively higher-volume categories, but the rates did not decrease between hospitals performing 236 to 644 arthroplasties per year and those performing ≥645 arthroplasties per year. Mortality rates for hospitals with ≥645 total knee arthroplasties per year were significantly lower (p < 0.05) than those below the threshold. Our study supports the use of SSLR analysis of ROC curves

  3. Correlation and Prediction of Phase Equilibria and Volumetric Behaviour of Hyperbaric Binary Fluids Corrélation et prédiction des équilibres de phases et du comportement volumétrique de fluides hyperbares binaires

    Directory of Open Access Journals (Sweden)

    Stamataki S. K.

    2006-11-01

    Full Text Available The capabilities of cubic Equations of State (EoS in the correlation and the prediction of phase equilibria at hyperbaric conditions is examined. PVT data of pure compounds as well as VLE and volumetric data of binary mixtures up to 2000 bar are used. Correlation and prediction results are presented with the translated and modified Peng-Robinson (t - mPR EoS and EoS/GE models. The performance of cubic EoS with a single interaction parameter (kij in describing VLE is remarkable considering the level of pressures involved. The same is valid for the PVT results including the relative liquid volumes of the C1/nC24 system. With typical errors of about 10% deviations in pressure of 100 - 200 bar are, of course, encountered which can be eliminated by the use of second interaction coefficient in the covolume combining rule. Predicted kij values obtained from generalized correlations developed from low pressure VLE data provide reasonable results for systems with hydrocarbons up to nC16 even at high pressures, but fail for higher asymmetric ones. Volume translation is essential for PVT predictions. The temperature independent translation of t - mPR and that of Jhaveri and Yougren give very satisfactory results. LCVM provides the best results of the EoS/GE models studied and gives very good predictions for rather symmetric systems which become poorer with asymmetric ones at very high pressures. La capacité des équations d'état (EoS cubiques pour corréler et prédire les équilibres de phases en conditions hyperbares est analysée. Les données PVT de corps purs ainsi que les données d'équilibres liquide-vapeur (VLE et volumétriques pour des mélanges binaires, jusqu'à 2000 bar sont utilisées. Les résultats des corrélations et des prédictions sont présentés pour l'équation de Peng-Robinson translatée et modifiée (t - mPR, ainsi que pour les modèles EoS/GE. Les performances des EoS cubiques avec un paramètre d'interaction unique (kij pour

  4. Wizlaw III og minnesangen

    DEFF Research Database (Denmark)

    Pontoppidan, Maria

    2012-01-01

    Artikel om den sidste slaviske Rügenfyrste, Wizlaw III (1265/68-1325), der traditionelt har været identificeret med minnesangeren Wizlaw den Unge. Om de bevarede sange og om minnesangens rolle ved det rügenske fyrstehof.......Artikel om den sidste slaviske Rügenfyrste, Wizlaw III (1265/68-1325), der traditionelt har været identificeret med minnesangeren Wizlaw den Unge. Om de bevarede sange og om minnesangens rolle ved det rügenske fyrstehof....

  5. Renormalized Volume

    Science.gov (United States)

    Gover, A. Rod; Waldron, Andrew

    2017-09-01

    We develop a universal distributional calculus for regulated volumes of metrics that are suitably singular along hypersurfaces. When the hypersurface is a conformal infinity we give simple integrated distribution expressions for the divergences and anomaly of the regulated volume functional valid for any choice of regulator. For closed hypersurfaces or conformally compact geometries, methods from a previously developed boundary calculus for conformally compact manifolds can be applied to give explicit holographic formulæ for the divergences and anomaly expressed as hypersurface integrals over local quantities (the method also extends to non-closed hypersurfaces). The resulting anomaly does not depend on any particular choice of regulator, while the regulator dependence of the divergences is precisely captured by these formulæ. Conformal hypersurface invariants can be studied by demanding that the singular metric obey, smoothly and formally to a suitable order, a Yamabe type problem with boundary data along the conformal infinity. We prove that the volume anomaly for these singular Yamabe solutions is a conformally invariant integral of a local Q-curvature that generalizes the Branson Q-curvature by including data of the embedding. In each dimension this canonically defines a higher dimensional generalization of the Willmore energy/rigid string action. Recently, Graham proved that the first variation of the volume anomaly recovers the density obstructing smooth solutions to this singular Yamabe problem; we give a new proof of this result employing our boundary calculus. Physical applications of our results include studies of quantum corrections to entanglement entropies.

  6. Combustor Design Criteria Validation. Volume III. User’s Manual

    Science.gov (United States)

    1979-02-01

    plenum annulus is condut .- ted based upon the qeneralized one-dimensional continuous flow- analysis approach of Shapiro . The analysis considers the...time. it was shown by the authors that a good correlation with the burning rate data could be obtained by taking thermal con- ductivity and CD as a...calculated using the coefficient given in Equation 39. II h - 2 K (l+0.3Pr 3Re2 H- ) (39)D~ m2 -K) where k is the thermal conductivity of fuel vapor

  7. Snohomish Estuary Wetlands Study Volume III. Classification and Mapping

    Science.gov (United States)

    1978-07-01

    an abundance of other flowering annuals and perennials are characteristic. S*312 Beach Grassland Strands of beach or dune grasses closely associated...Jetty Island, 27 September, 1977, Scientific Name Common Name A0,11lsa millefolium Commn Yarrow 4goseris sp. Valse- dandelion Alnus rubra Red Alder

  8. Annotated Bibliography for Lake Erie. Volume III. Engineering,

    Science.gov (United States)

    1974-10-01

    redistributing the heat gained through the surface. Benninghoff, W. S. - See: A. L. Stevenson , No. 527. Berg, D. W. - See: J. H. Balsillie, No. 79. 93. Berg, D. W...discharges on the water uses are discussed together with control measures required to protect the uses. 527. Stevenson , A. L. and W. S. Benninghoff...amorphous muck. Mesic site conditions with mull humus are indicated. The forest bed is overlain successively by fibrous (marsh?) peat, pond ooze, and

  9. FY2000 End of Year Report: Volume III

    Science.gov (United States)

    2000-11-01

    of one experiment informing and shaping the design of the next. Virtual & Constructive Simulations Discussions & War Games Constructive Model Case...Command Vietnam MLRS Multiple Launch Rocket System MOBA Military Operations in Built-up Areas MOUT Military Operations in Urban Terrain MRT Mobile...Operations in Urban Terrain,” by Jeb Stewart, looks at the role of engineers in the Army After Next and urban combat. During Army After Next war games the

  10. Passive solar design handbook. Volume III. Passive solar design analysis

    Energy Technology Data Exchange (ETDEWEB)

    Jones, R.W.; Balcomb, J.D.; Kosiewicz, C.E.; Lazarus, G.S.; McFarland, R.D.; Wray, W.O.

    1982-07-01

    Simple analytical methods concerning the design of passive solar heating systems are presented with an emphasis on the average annual heating energy consumption. Key terminology and methods are reviewed. The solar load ratio (SLR) is defined, and its relationship to analysis methods is reviewed. The annual calculation, or Load Collector Ratio (LCR) method, is outlined. Sensitivity data are discussed. Information is presented on balancing conservation and passive solar strategies in building design. Detailed analysis data are presented for direct gain and sunspace systems, and details of the systems are described. Key design parameters are discussed in terms of their impact on annual heating performance of the building. These are the sensitivity data. The SLR correlations for the respective system types are described. The monthly calculation, or SLR method, based on the SLR correlations, is reviewed. Performance data are given for 9 direct gain systems and 15 water wall and 42 Trombe wall systems. (LEW)

  11. Solar central receiver prototype heliostat. Volume III. Cost estimates

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-06-01

    The Boeing heliostat design can be produced and installed for a Capital Cost of $42 per square meter at high commercial plant quantities and rates. This is 14% less than the DOE cost target. Even at a low commercial plant production rate of 25,000 heliostats per year the Capital Cost of $48 per square meter is 2% less than the cost goal established by the DOE. Projected capital costs and 30 year maintenance costs for three scenarios of production and installation are presented: (1) commercial rate production of 25,000, 250,000, and 1,000,000 heliostats per year; (2) a one-time only production quantity of 2500 heliostats; and (3) commercial rate production of 25,000 heliostats per year with each plant (25,000 heliostats) installed at widely dispersed sites throughout the Southwestern United States. These three scenarios for solar plant locations and the manufacturing/installation processes are fully described, and detailed cost breakdowns for the three scenarios are provided.

  12. Geopressured geothermal bibliography. Volume III. (Geopressure thesaurus). Second edition

    Energy Technology Data Exchange (ETDEWEB)

    Sepehrnoori, K.; Carter, F.; Schneider, R.; Street, S.; McGill, K.

    1985-05-01

    This thesaurus of terminology associated with the geopressured geothermal energy field has been developed as a part of the Geopressured Geothermal Information System data base. The subject scope includes: (1) geopressure resource assessment; (2) geology, hydrology, and geochemistry of geopressured systems; (3) geopressure exploration and exploration technology; (4) geopressured reservoir engineering and drilling technology; (5) economic aspects; (6) environmental aspects; (7) legal, institutional, and sociological aspects; (8) electrical and nonelectrical utilization; and (9) other energy sources, especially methane and other fossil fuel reserves, associated with geopressured reservoirs.

  13. Wilderness Study Report : Volume III : Public Hearing Transcripts

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains public hearing transcripts from the Kenai National Moose Range Wilderness Hearing. This hearing was held to obtain information relating to...

  14. Photovoltaic venture analysis. Final report. Volume III. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Costello, D.; Posner, D.; Schiffel, D.; Doane, J.; Bishop, C.

    1978-07-01

    This appendix contains a brief summary of a detailed description of alternative future energy scenarios which provide an overall backdrop for the photovoltaic venture analysis. Also included is a summary of a photovoltaic market/demand workshop, a summary of a photovoltaic supply workshop which used cross-impact analysis, and a report on photovoltaic array and system prices in 1982 and 1986. The results of a sectorial demand analysis for photovoltaic power systems used in the residential sector (single family homes), the service, commercial, and institutional sector (schools), and in the central power sector are presented. An analysis of photovoltaics in the electric utility market is given, and a report on the industrialization of photovoltaic systems is included. A DOE information memorandum regarding ''A Strategy for a Multi-Year Procurement Initiative on Photovoltaics (ACTS No. ET-002)'' is also included. (WHK)

  15. Training Career Ladder AFSC 751X2. Volume III.

    Science.gov (United States)

    1981-01-01

    u0 -4V n on < .z - < .0=w x =Z 14 W! < " e- I.!;. ) En 2 E H C l>)n q 0 w0r M> > 35 JOB INTEREST AND IERCEIVED !Li ,N OF’ TALEN ... AN TRAINNG BY...PERSONNEL WHEN COMPUTERS MALFUNCTION 2.6 13 MAIL OFFICER EDUCATIONAL TRANSCRIPTS TO AIR FORCE INSTITUTE OF TECHNOLOGY 2.6 6 DESTROY TESTS 2.5 21 42

  16. Measurement and modeling of advanced coal conversion processes, Volume III

    Energy Technology Data Exchange (ETDEWEB)

    Ghani, M.U.; Hobbs, M.L.; Hamblen, D.G. [and others

    1993-08-01

    A generalized one-dimensional, heterogeneous, steady-state, fixed-bed model for coal gasification and combustion is presented. The model, FBED-1, is a design and analysis tool that can be used to simulate a variety of gasification, devolatilization, and combustion processes. The model considers separate gas and solid temperatures, axially variable solid and gas flow rates, variable bed void fraction, coal drying, devolatilization based on chemical functional group composition, depolymerization, vaporization and crosslinking, oxidation, and gasification of char, and partial equilibrium in the gas phase.

  17. Problems of Air Defense - and - Appedicies. Volumes I-III

    Science.gov (United States)

    1951-08-01

    u6dertak~e a major project mi~ air defeuse prokbie.ma. nrespon~se to thlis rei~et an~d vih the ’scope s~omewhat broadene in z-ectognition of the...enti_- rou -~Preliminary oral presenitations of the?𔃾e con- clusions_ were gitven to -representatives of thjsos;LI gnce rt b l and Z-1 Jun-e in...Coast should be established at the earliest possible 4tine. TwUo-a.d•. oral ground radars are recomnnended in the Northh.vest. ..... A-_•N’ THEN PIh

  18. Secretary's annual report to Congress. Volume III. Project summaries

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-01-01

    Progress and status of representative projects in each program within DOE are summarized. Subjects covered and the number of projects reported on are: conservation (2); fossil energy (11); nuclear energy (5); renewable energy resources (16); energy production and power marketing (3); general science (11); defense programs (7); contingency planning (3); and management and oversight (1). (MCW)

  19. PISA 2015 Results: Students' Well-Being. Volume III

    Science.gov (United States)

    OECD Publishing, 2017

    2017-01-01

    The OECD Programme for International Student Assessment (PISA) examines not just what students know in science, reading and mathematics, but what they can do with what they know. This report is the product of a collaborative effort between the countries participating in PISA, the national and international experts and institutions working within…

  20. Survey of biomass gasification. Volume III. Current technology and research

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-04-01

    This survey of biomass gasification was written to aid the Department of Energy and the Solar Energy Research Institute Biological and Chemical Conversion Branch in determining the areas of gasification that are ready for commercialization now and those areas in which further research and development will be most productive. Chapter 8 is a survey of gasifier types. Chapter 9 consists of a directory of current manufacturers of gasifiers and gasifier development programs. Chapter 10 is a sampling of current gasification R and D programs and their unique features. Chapter 11 compares air gasification for the conversion of existing gas/oil boiler systems to biomass feedstocks with the price of installing new biomass combustion equipment. Chapter 12 treats gas conditioning as a necessary adjunct to all but close-coupled gasifiers, in which the product is promptly burned. Chapter 13 evaluates, technically and economically, synthesis-gas processes for conversion to methanol, ammonia, gasoline, or methane. Chapter 14 compiles a number of comments that have been assembled from various members of the gasifier community as to possible roles of the government in accelerating the development of gasifier technology and commercialization. Chapter 15 includes recommendations for future gasification research and development.

  1. Analyzing Global Interdependence. Volume III. Methodological Perspectives and Research Implications,

    Science.gov (United States)

    1974-11-01

    Deutsch, The Nerves of Government: Models of Political Communication and Control (New York: The Free Press of Glencoe, 1963); and JUrgen Habermas ...cybernetics and Habermas ’ Marxian writings on communicative competence. They may make possible respecifications of mixed interest choice situations in ways

  2. Biological Effects of Nonionizing Electromagnetic Radiation. Volume III, Number 3.

    Science.gov (United States)

    1979-03-01

    NEURALGIA . (Eng.) Gregg, J. H. (Dental Re;. which is shorter by one decade than the 0.3 msec Center , The Univ. North Carolina , Chapel Hi l l , NC...paroxysmal trlgein m nal neur- other contactless stimulating method involved al gias to achieve pain relief. Facial pain was exc i ting the nerve by...after conventional microwave Irradiation . Regional to up to 500 mW/cm2 for 60 mm sustained facial differences in acety lchol i ne level s i n the

  3. Intrasystem Electromagnetic Compatibility Analysis Program. Volume III. Computer Program Documentation

    Science.gov (United States)

    1974-12-01

    S(4) IN COMMON BLOCK SPIRO BWC S(5) IN COMMON BLOCK SPIRO ADJLIM S(1) IN COMMON BLOCK SPIRO F5 S(3) IN COMMON BLOCK SPIRO FL S(2) IN COMMON BLOCK...NRZ 102 CO3QD 118 S or C 3 ot 4 BPP 103 GAUSS 1.19 EED 5 PPM 104 CHIRP 120 CASE 6 TEL 105 FSK 106 SIG CODE PAM 107 VO 115 RADAR 200 CV 116 AM 301 NO 117...code (source/receptor type code) MOPSIG CDoE SR CODE PDM 101. RE 1 NRZ 102 PO 2 BPP 103 S/C 3/4 PPM 104 EED 5 TEL 105 CASE 6 PAM 107 , ESPIKE 108 Units

  4. Nuclear Blast Response Computer Program. Volume III. Program Listing.

    Science.gov (United States)

    1981-08-01

    434 .. "" " - 14. MONITORING AGENCY NAME & ADDRESS(Il different from Controlltn Office) 15. SECURIT CLASS. of ths repot) Director Unclassified Defense...C -Cc 4u 41 (- 4, 4g - w bz 4 cca0 Cca Z~ CL 0 C 0. 200C Oi Zr LA 0.0. o, 0. -3 C7 < - 0 -< - -~ _I-_-..- . g a 1 1 -- 0-1-0 . a _ ’ _jg .-- gut

  5. Photovoltaic venture analysis. Final report. Volume III. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Costello, D.; Posner, D.; Schiffel, D.; Doane, J.; Bishop, C.

    1978-07-01

    This appendix contains a brief summary of a detailed description of alternative future energy scenarios which provide an overall backdrop for the photovoltaic venture analysis. Also included is a summary of a photovoltaic market/demand workshop, a summary of a photovoltaic supply workshop which used cross-impact analysis, and a report on photovoltaic array and system prices in 1982 and 1986. The results of a sectorial demand analysis for photovoltaic power systems used in the residential sector (single family homes), the service, commercial, and institutional sector (schools), and in the central power sector are presented. An analysis of photovoltaics in the electric utility market is given, and a report on the industrialization of photovoltaic systems is included. A DOE information memorandum regarding ''A Strategy for a Multi-Year Procurement Initiative on Photovoltaics (ACTS No. ET-002)'' is also included. (WHK)

  6. 深长隧道涌水量预测影响因素评价分析%Analysis on affecting factors in prediction of gushing water volume in deep-buried and long tunnel

    Institute of Scientific and Technical Information of China (English)

    李显伟

    2014-01-01

    The water inflow in tunnel is in concerned with its construction , its characteristics and the hydrogeological environment it locates in .In this light,an accurate prediction of the gushing water volume is premised on the wise selection and analysis of major influential factors .The paper reviews in detail the geological and hydrological environment the deep-buried and long tunnels in China surrounded by .Based on this,the analytic hierarchy process is used ,in the effort of building an assessment model to quantify all the influential factors that affect the gushing water volume in deep-buried and long tunnel .The results indicate that the lithologic characters and the water-rich property of the stratum , the type of the underground water , the geological structure , the topography , the annual average precipitation are all identified as key parameters .Hopefully , the paper can be of scientific use for the perdiction of gushing water volume in deep-buried and long tunnel .%隧道涌水不但与施工条件和隧道特征有关,而且受到水文地质条件的影响,对影响隧道涌水的主要因素的遴选和分析是准确进行隧道涌水量预测的前提。对我国深长隧道地质与水文地质条件进行详细分析,采用层次分析法建立深长隧道涌水量影响因素评价模型,定量确定了各因素的权重。研究结果表明:地层岩性、岩层富水性、地下水类型、地质构造、地形地貌和年均降水量是影响深长隧道涌水量的关键因素。本文分析结果为深长隧道涌水量预测分析提供了科学依据。

  7. Cervical Gross Tumor Volume Dose Predicts Local Control Using Magnetic Resonance Imaging/Diffusion-Weighted Imaging—Guided High-Dose-Rate and Positron Emission Tomography/Computed Tomography—Guided Intensity Modulated Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Dyk, Pawel; Jiang, Naomi; Sun, Baozhou; DeWees, Todd A. [Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri (United States); Fowler, Kathryn J.; Narra, Vamsi [Department of Diagnostic Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri (United States); Garcia-Ramirez, Jose L.; Schwarz, Julie K. [Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri (United States); Grigsby, Perry W., E-mail: pgrigsby@wustl.edu [Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri (United States); Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri (United States); Division of Gynecologic Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri (United States); Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri (United States)

    2014-11-15

    Purpose: Magnetic resonance imaging/diffusion weighted-imaging (MRI/DWI)-guided high-dose-rate (HDR) brachytherapy and {sup 18}F-fluorodeoxyglucose (FDG) — positron emission tomography/computed tomography (PET/CT)-guided intensity modulated radiation therapy (IMRT) for the definitive treatment of cervical cancer is a novel treatment technique. The purpose of this study was to report our analysis of dose-volume parameters predicting gross tumor volume (GTV) control. Methods and Materials: We analyzed the records of 134 patients with International Federation of Gynecology and Obstetrics stages IB1-IVB cervical cancer treated with combined MRI-guided HDR and IMRT from July 2009 to July 2011. IMRT was targeted to the metabolic tumor volume and lymph nodes by use of FDG-PET/CT simulation. The GTV for each HDR fraction was delineated by use of T2-weighted or apparent diffusion coefficient maps from diffusion-weighted sequences. The D100, D90, and Dmean delivered to the GTV from HDR and IMRT were summed to EQD2. Results: One hundred twenty-five patients received all irradiation treatment as planned, and 9 did not complete treatment. All 134 patients are included in this analysis. Treatment failure in the cervix occurred in 24 patients (18.0%). Patients with cervix failures had a lower D100, D90, and Dmean than those who did not experience failure in the cervix. The respective doses to the GTV were 41, 58, and 136 Gy for failures compared with 67, 99, and 236 Gy for those who did not experience failure (P<.001). Probit analysis estimated the minimum D100, D90, and Dmean doses required for ≥90% local control to be 69, 98, and 260 Gy (P<.001). Conclusions: Total dose delivered to the GTV from combined MRI-guided HDR and PET/CT-guided IMRT is highly correlated with local tumor control. The findings can be directly applied in the clinic for dose adaptation to maximize local control.

  8. The clot burden score, the Boston Acute Stroke Imaging Scale, the cerebral blood volume ASPECTS, and two novel imaging parameters in the prediction of clinical outcome of ischemic stroke patients receiving intravenous thrombolytic therapy

    Energy Technology Data Exchange (ETDEWEB)

    Sillanpaa, Niko; Hakomaki, Jari; Lahteela, Arto; Dastidar, Prasun; Soimakallio, Seppo [Tampere University Hospital, Medical Imaging Center, Tampere (Finland); Saarinen, Jukka T.; Numminen, Heikki; Elovaara, Irina [Tampere University Hospital, Department of Neurology, Tampere (Finland); Rusanen, Harri [Oulu University Hospital, Department of Neurology, Oulu (Finland)

    2012-07-15

    Recently two classification methods based on the location and the extent of thrombosis detected with CT angiography have been introduced: the Boston Acute Stroke Imaging Scale (BASIS) and the clot burden score (CBS). We studied the performance of BASIS and CBS in predicting good clinical outcome (mRS {<=}2 at 90 days) in an acute (<3 h) stroke cohort treated with intravenous thrombolytic therapy. Eighty-three consecutive patients who underwent multimodal CT were analyzed. Binary logistic regression model was used to assess how BASIS, CBS, and cerebral blood volume (CBV) ASPECTS predict favorable clinical outcome. Diagnostic sensitivities and specificities were calculated and compared. Patients with low CBS and CBV ASPECTS scores and major strokes according to BASIS had significantly higher admission NIHSS scores, larger perfusion defects, and more often poor clinical outcome. In logistic regression analysis, CBV ASPECTS, CBS and BASIS were significantly associated with the clinical outcome. The performance of BASIS improved when patients with thrombosis of the M2 segment of the middle cerebral artery were classified as having minor stroke (M1-BASIS). In the anterior circulation, the sum of CBS and CBV ASPECTS (CBSV) proved to be the most robust predictor of favorable outcome. CBV ASPECTS and CBS had high sensitivity but moderate to poor specificity while BASIS was only moderately sensitive and specific. CBS, BASIS, and CBV ASPECTS are statistically robust and sensitive but unspecific predictors of good clinical outcome. Two new derived imaging parameters, CBSV and M1-BASIS, share these properties and may have increased prognostic value. (orig.)

  9. BES-III distributed computing status

    Science.gov (United States)

    Belov, S. D.; Deng, Z. Y.; Korenkov, V. V.; Li, W. D.; Lin, T.; Ma, Z. T.; Nicholson, C.; Pelevanyuk, I. S.; Suo, B.; Trofimov, V. V.; Tsaregorodtsev, A. U.; Uzhinskiy, A. V.; Yan, T.; Yan, X. F.; Zhang, X. M.; Zhemchugov, A. S.

    2016-09-01

    The BES-III experiment at the Institute of High Energy Physics (Beijing, China) is aimed at the precision measurements in e+e- annihilation in the energy range from 2.0 till 4.6 GeV. The world's largest samples of J/psi and psi' events and unique samples of XYZ data have been already collected. The expected increase of the data volume in the coming years required a significant evolution of the computing model, namely shift from a centralized data processing to a distributed one. This report summarizes a current design of the BES-III distributed computing system, some of key decisions and experience gained during 2 years of operations.

  10. Biochemical kinetics in changing volumes.

    Science.gov (United States)

    Pawłowski, Piotr H; Zielenkiewicz, Piotr

    2004-01-01

    The need of taking into account the change of compartment volume when developing chemical kinetics analysis inside the living cell is discussed. Literature models of a single enzymatic Michaelis-Menten process, glycolytic oscillations, and mitotic cyclin oscillations were tested with appropriate theoretical extension in the direction of volume modification allowance. Linear and exponential type of volume increase regimes were compared. Due to the above, in a growing cell damping of the amplitude, phase shift, and time pattern deformation of the metabolic rhythms considered were detected, depending on the volume change character. The performed computer simulations allow us to conclude that evolution of the cell volume can be an essential factor of the chemical kinetics in a growing cell. The phenomenon of additional metabolite oscillations caused by the periodic cell growth and division was theoretically predicted and mathematically described. Also, the hypothesis of the periodized state in the growing cell as the generalization of the steady-state was formulated.

  11. 基于波前快速推进法的页岩气储层动用预测%Prediction of the Drainage Volume of Shale Gas Reservoir with Fast Marching Method

    Institute of Scientific and Technical Information of China (English)

    滕柏路; 程林松; 黄世军; 贾振; 艾爽

    2016-01-01

    The development of unconventional energy,especially shale gas reservoir,is getting more and more attention;however,prediction of the drainage volume of shale gas reservoir is to be improved. Fast marching method is a fast and efficient method to present the front of the pressure. Taking into account desorption and slippage,the flow regions can be divided with the compound linear flow model by Van Kruysdijk. The Eikonal equation of the matrix and the fracture can be obtained and solved with fast marching method,then drainage volume of the reservoir at different time can be obtained,and the comparison of the condition whether or not considering desorption and the effect of slippage can be seen easily. The result shows that slippage accelerates the increase of drainage volume and desorption slows the increase of drainage volume. The influence of slippage is greater than desorption.%对非常规能源尤其是页岩气藏的开发越来越受到人们的重视,然而,目前对页岩气藏动用情况的预测还有待提高。波前快速推进法是一种可以快速高效地预测波前运移情况的方法,在考虑页岩基质吸附解吸特性,及基质孔隙中气体的滑脱作用影响的前提下,利用Van Kruysdijk提出的多段压裂水平井的复合线性流模型,将储层划分不同的流动区域,并分别建立基质与裂缝的程函方程,基于波前快速推进法求解程函方程,从而达到对多段压裂水平井页岩气储层的动用进行预测的目的。绘制了储层动用情况与时间的关系图,对比了考虑解吸和滑脱与不考虑解吸和滑脱的储层动用情况。结果表明,滑脱效应加快了储层的动用速度对储层动用影响较大,而解吸作用降低了储层的动用速度对储层动用影响较小。

  12. Prediction of treatment outcome by cisplatin-DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin-radiation (RADPLAT).

    NARCIS (Netherlands)

    Hoebers, F.J.; Pluim, D.; Verheij, M.; Balm, A.J.M.; Bartelink, H.; Schellens, J.H.M.; Begg, A.C.

    2006-01-01

    The purpose of our study was to test the predictive value of cisplatin-DNA adduct levels in head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin-radiation. Patients with advanced-stage HNSCC were treated within a randomized trial, investigating the optimal route of cisplatin

  13. Project NECESSITIES, Phase III. Volume III: Case Studies in Teacher Training.

    Science.gov (United States)

    Abt Associates, Inc., Cambridge, MA.

    The staff of Project NECESSITIES conducted 2 workshops for educators concerned with curriculum for American Indian (including Eskimo) students. The purpose of these sessions was to familiarize participants with techniques pertinent to development of curriculum for Indian students at both the elementary and secondary school levels. The practica…

  14. Boletin de Informacion Educativa, Ano III, No. 7 (Educational Information Bulletin, Volume III, No. 7).

    Science.gov (United States)

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  15. Boletin de Informacion Educativa, Ano III, No. 6 (Educational Information Bulletin, Volume III, No. 6).

    Science.gov (United States)

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  16. Silicon photonics III systems and applications

    CERN Document Server

    Lockwood, David

    2016-01-01

    This book is volume III of a series of books on silicon photonics. It reports on the development of fully integrated systems where many different photonics component are integrated together to build complex circuits. This is the demonstration of the fully potentiality of silicon photonics. It contains a number of chapters written by engineers and scientists of the main companies, research centers and universities active in the field. It can be of use for all those persons interested to know the potentialities and the recent applications of silicon photonics both in microelectronics, telecommunication and consumer electronics market.

  17. Calculus III essentials

    CERN Document Server

    REA, Editors of

    2012-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Calculus III includes vector analysis, real valued functions, partial differentiation, multiple integrations, vector fields, and infinite series.

  18. Effect of Class III bone anchor treatment on airway.

    Science.gov (United States)

    Nguyen, Tung; De Clerck, Hugo; Wilson, Michael; Golden, Brent

    2015-07-01

    To compare airway volumes and minimum cross-section area changes of Class III patients treated with bone-anchored maxillary protraction (BAMP) versus untreated Class III controls. Twenty-eight consecutive skeletal Class III patients between the ages of 10 and 14 years (mean age, 11.9 years) were treated using Class III intermaxillary elastics and bilateral miniplates (two in the infra-zygomatic crests of the maxilla and two in the anterior mandible). The subjects had cone beam computed tomographs (CBCTs) taken before initial loading (T1) and 1 year out (T2). Twenty-eight untreated Class III patients (mean age, 12.4 years) had CBCTs taken and cephalograms generated. The airway volumes and minimum cross-sectional area measurements were performed using Dolphin Imaging 11.7 3D software. The superior border of the airway was defined by a plane that passes through the posterior nasal spine and basion, while the inferior border included the base of the epiglottis to the lower border of C3. From T1 to T2, airway volume from BAMP-treated subjects showed a statistically significant increase (1499.64 mm(3)). The area in the most constricted section of the airway (choke point) increased slightly (15.44 mm(2)). The airway volume of BAMP patients at T2 was 14136.61 mm(3), compared with 14432.98 mm(3) in untreated Class III subjects. Intraexaminer correlation coefficients values and 95% confidence interval values were all greater than .90, showing a high degree of reliability of the measurements. BAMP treatment did not hinder the development of the oropharynx.

  19. Renormalized Volume

    CERN Document Server

    Gover, A Rod

    2016-01-01

    For any conformally compact manifold with hypersurface boundary we define a canonical renormalized volume functional and compute an explicit, holographic formula for the corresponding anomaly. For the special case of asymptotically Einstein manifolds, our method recovers the known results. The anomaly does not depend on any particular choice of regulator, but the coefficients of divergences do. We give explicit formulae for these divergences valid for any choice of regulating hypersurface; these should be relevant to recent studies of quantum corrections to entanglement entropies. The anomaly is expressed as a conformally invariant integral of a local Q-curvature that generalizes the Branson Q-curvature by including data of the embedding. In each dimension this canonically defines a higher dimensional generalization of the Willmore energy/rigid string action. We show that the variation of these energy functionals is exactly the obstruction to solving a singular Yamabe type problem with boundary data along the...

  20. Anomalia de Classe III

    OpenAIRE

    2014-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária Introdução: A anomalia de classe III, é uma má oclusão que afeta os indivíduos psicologicamente, pois hoje em dia, a estética é socialmente valorizada. Deste modo, o diagnóstico deve ser executado precocemente para que os indivíduos portadores desta anomalia, possam ser acompanhados desde criança, pelos profissionais área da Medicina...