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Sample records for volume deceleration parameter

  1. Cosmological models with constant deceleration parameter

    Energy Technology Data Exchange (ETDEWEB)

    Berman, M.S.; de Mello Gomide, F.

    1988-02-01

    Berman presented elsewhere a law of variation for Hubble's parameter that yields constant deceleration parameter models of the universe. By analyzing Einstein, Pryce-Hoyle and Brans-Dicke cosmologies, we derive here the necessary relations in each model, considering a perfect fluid.

  2. Asymmetry in the reconstructed deceleration parameter

    CERN Document Server

    Bernal, Carla; Motta, Veronica

    2016-01-01

    We study the orientation dependence of the reconstructed deceleration parameter as a function of redshift. We use the Union 2 and Loss datasets, by using the well known preferred axis discussed in the literature, finding the best fit reconstructed deceleration parameter. We found that a low redshift transition of the reconstructed $q(z)$ is clearly absent in one direction and amazingly sharp in the opposite one. We discuss the possibility that such a behavior can be associated with large scale structures affecting the data.

  3. A parametric reconstruction of the deceleration parameter

    Science.gov (United States)

    Mamon, Abdulla Al; Das, Sudipta

    2017-07-01

    The present work is based on a parametric reconstruction of the deceleration parameter q( z) in a model for the spatially flat FRW universe filled with dark energy and non-relativistic matter. In cosmology, the parametric reconstruction technique deals with an attempt to build up a model by choosing some specific evolution scenario for a cosmological parameter and then estimate the values of the parameters with the help of different observational datasets. In this paper, we have proposed a logarithmic parametrization of q( z) to probe the evolution history of the universe. Using the type Ia supernova, baryon acoustic oscillation and the cosmic microwave background datasets, the constraints on the arbitrary model parameters q0 and q1 are obtained (within 1σ and 2σ confidence limits) by χ 2-minimization technique. We have then reconstructed the deceleration parameter, the total EoS parameter ω _tot, the jerk parameter and have compared the reconstructed results of q( z) with other well-known parametrizations of q( z). We have also shown that two model selection criteria (namely, the Akaike information criterion and Bayesian information criterion) provide a clear indication that our reconstructed model is well consistent with other popular models.

  4. A parametric reconstruction of the deceleration parameter

    CERN Document Server

    Mamon, Abdulla Al

    2016-01-01

    The present work is based on a parametric reconstruction of the deceleration parameter $q(z)$ in a model for the spatially flat FRW universe filled with dark energy and non- relativistic matter. We have proposed a divergence-free logarithmic parametrization of $q(z)$ to probe the entire evolution history of the universe. Using the SN Ia and Hubble parameter datasets, the constraints on the arbitrary model parameters $q_{0}$ and $q_{1}$ are obtained (within $1\\sigma$ and $2\\sigma$ confidence limits) by $\\chi^{2}$-minimization technique. We have then reconstructed the deceleration parameter, the total EoS parameter $\\omega_{tot}$, the jerk parameter and have compared the reconstructed results with the spatially flat $\\Lambda$CDM model. It has been found that the behavior of $q(z)$ and $\\omega_{tot}$ in our model are very similar (within $1\\sigma$ confidence limit) to that of the $\\Lambda$CDM model if we consider Type Ia Supernova (SN Ia) dataset only, but the evolutions of $q(z)$ and $\\omega_{tot}$ are differen...

  5. The deceleration parameter in `tilted' Friedmann universes

    CERN Document Server

    Tsagas, Christos G

    2015-01-01

    Large-scale peculiar motions are believed to reflect the local inhomogeneity and anisotropy of the universe, triggered by the ongoing process of structure formation. As a result, realistic observers do not follow the smooth Hubble flow, but have a peculiar, `tilt', velocity relative to it. Our Local Group of galaxies, in particular, moves with respect to the universal expansion at a speed of roughly 600~km/sec. Relative motion effects are known to interfere with the observations and their interpretation. The strong dipolar anisotropy seen in the the Cosmic Microwave Background, for example, is not a sign of real universal anisotropy, but a mere artifact of our peculiar motion relative to the Hubble flow. With these in mind, we look into the implications of large-scale bulk motions for the kinematics of their associated observers, by adopting a `tilted' Friedmann model. Our aim is to examine whether the deceleration parameter measured in the rest-frame of the bulk flow can differ from that of the actual univer...

  6. Interacting Dark Fluid in Anisotropic Universe with Dynamical Deceleration Parameter

    Science.gov (United States)

    Adhav, K. S.; Bokey, V. D.; Bansod, A. S.; Munde, S. L.

    2016-10-01

    In this paper we have studied the anisotropic and homogeneous Bianchi Type-I and V universe filled with Interacting Dark Matter and Holographic Dark Energy. The solutions of field equations are obtained for both models under the assumption of linearly varying deceleration parameter which yields dynamical deceleration parameter. It has been observed that the anisotropy of expansion dies out very quickly (soon after inflation) in both models (B-I, B-V). The physical and geometrical parameters for the both models have been obtained and discussed in details.

  7. Cosmological Models with Variable Deceleration Parameter in Lyra's Manifold

    CERN Document Server

    Pradhan, A; Singh, C B

    2006-01-01

    FRW models of the universe have been studied in the cosmological theory based on Lyra's manifold. A new class of exact solutions has been obtained by considering a time dependent displacement field for variable deceleration parameter from which three models of the universe are derived (i) exponential (ii) polynomial and (iii) sinusoidal form respectively. The behaviour of these models of the universe are also discussed. Finally some possibilities of further problems and their investigations have been pointed out.

  8. Three thermodynamically-based parameterizations of the deceleration parameter

    CERN Document Server

    del Campo, Sergio; Herrera, Ramon; Pavon, Diego

    2012-01-01

    We propose, and constrain with the latest observational data, three model-independent parameterizations of the cosmic deceleration parameter $q(z)$. They are well behaved and stay finite at all redshifts. We construct them by fixing the value of $q$ at high redshift, $q(z \\gg 1) = 1/2$ (as demanded by cosmic structure formation), and at the far future, $q(z = -1) = -1$, and smoothly interpolating $q(z)$ between them. The fixed point at $z = -1$ is not arbitrarily chosen; it readily follows from the second law of thermodynamics. This fairly reduces the ample latitude in parameterizing $q(z)$.

  9. Cosmology In Terms Of The Deceleration Parameter. Part I

    CERN Document Server

    Bolotin, Yu L; Lemets, O A; Yerokhin, D A; Zazunov, L G

    2015-01-01

    In the early seventies, Alan Sandage defined cosmology as the search for two numbers: Hubble parameter ${{H}_{0}}$ and deceleration parameter ${{q}_{0}}$. The first of the two basic cosmological parameters (the Hubble parameter) describes the linear part of the time dependence of the scale factor. Treating the Universe as a dynamical system it is natural to assume that it is non-linear: indeed, linearity is nothing more than approximation, while non-linearity represents the generic case. It is evident that future models of the Universe must take into account different aspects of its evolution. As soon as the scale factor is the only dynamical variable, the quantities which determine its time dependence must be essentially present in all aspects of the Universe' evolution. Basic characteristics of the cosmological evolution, both static and dynamical, can be expressed in terms of the parameters ${{H}_{0}}$ and ${{q}_{0}}$. The very parameters (and higher time derivatives of the scale factor) enable us to const...

  10. Cosmology In Terms Of The Deceleration Parameter. Part II

    CERN Document Server

    Bolotin, Yu L; Lemets, O A; Yerokhin, D A; Zazunov, L G

    2015-01-01

    In the early seventies, Alan Sandage defined cosmology as the search for two numbers: Hubble parameter ${{H}_{0}}$ and deceleration parameter ${{q}_{0}}$. The first of the two basic cosmological parameters (the Hubble parameter) describes the linear part of the time dependence of the scale factor. Treating the Universe as a dynamical system it is natural to assume that it is non-linear: indeed, linearity is nothing more than approximation, while non-linearity represents the generic case. It is evident that future models of the Universe must take into account different aspects of its evolution. As soon as the scale factor is the only dynamical variable, the quantities which determine its time dependence must be essentially present in all aspects of the Universe' evolution. Basic characteristics of the cosmological evolution, both static and dynamical, can be expressed in terms of the parameters ${{H}_{0}}$ and ${{q}_{0}}$. The very parameters (and higher time derivatives of the scale factor) enable us to const...

  11. Analysis on the Key Parameters of Aerospace Microminiaturization Decelerator

    Directory of Open Access Journals (Sweden)

    Xiangyang Jin

    2013-10-01

    Full Text Available A high efficiency special transmission decelerator is designed by scheme design, structural design, optimization design, and return difference analysis and computer simulation. Small teeth difference transmission with the first level bevel gear pair and the second level beveloid gear pair is adopted as the form of transmission in the decelerating system. Great torque and big bending moment are available by transmission ratio formula deduction, force analysis and strength analysis. The particle swarm optimization and the genetic algorithm have been combined and the mutation operator optimization model has been proposed to optimize the design of decelerator. Then the transmission with large transmission ratio, high torque, high power and high precision will be realized in small space. This model has solved the problems of particle swarm optimization in mechanical design. For example, there are more variables, it is constrained and it is easily precocious. This model has provided the theoretical basis for the optimum design of microminiaturization gear system.  

  12. Estimate on the deceleration parameter in a Universe with variable fine structure constant

    CERN Document Server

    Berman, M S; Berman, Marcelo S.; Trevisan, Luis A.

    2001-01-01

    We determine a cosmological model that include a positive acceleration of the Universe and a time decreasing fine structure constant. The present day deceleration parameter is estimated by us, according to our model and the available experimental data .

  13. Future Destiny of Quintessential Universe and Constraint on Model from Deceleration Parameter

    CERN Document Server

    Zhang, D H

    1999-01-01

    The evolution of the quintessence in various stages of the universe, the radiation-, matter-, and quintessence-dominated, is closely related with the tracking behavior and the deceleration parameter of the universe. We gave the explicit relation between the equation-of-state of the quintessence in the epoch of the matter-quintessence equality and the inverse power index of the quintessence potential, obtained the constraint on this potential parameter come from the present deceleration parameter, i.e., a low inverse power index. We point out that the low inverse power-law potential with a single term can not work for the tracking solution. In order to have both of the tracker and the suitable deceleration parameter it is necessary to introduce at least two terms in the quintessence potential. We give the future evolution of the quintessential universe.

  14. Future Destiny of Quintessential Universe and Constraint on Model from Deceleration Parameter

    Institute of Scientific and Technical Information of China (English)

    ZHANG De-Hai

    2002-01-01

    The evolution of the quintessence in various stages of the universe, i.e., the radiation-, matter-, andquintessence-dominated stages, is closely related with the tracking behavior and the deceleration parameter of theuniverse. We gave the explicit relation between the equation-of-state of the quintessence in the epoch of the matter-quintessence equality and the inverse power index of the quintessence potential, obtained the constraint on this potentialparameter comingfrom the present deceleration parameter, i.e., a low inverse power index.We point out that the lowinverse power-law potential with a single term cannot work for the tracking solution. In order to have both of the trackerand the suitable deceleration parameter it is necessary to introduce at least two terms in the quintessence potential. Wegive the future evolution of the quintessential universe.

  15. Role of the constant deceleration parameter in cosmological models with perfect fluid and dark energy

    CERN Document Server

    Pawar, D D; Mapari, R V

    2016-01-01

    The main purpose of the present paper is to investigate LRS Bianchi type I metric in the presence of perfect fluid and dark energy. In order to obtain a deterministic solution of the field equations we have assumed that, the two sources of the perfect fluid and dark energy interact minimally with separate conservation of their energy momentum tensors. The EoS parameter of the perfect fluid is also assumed to be constant. In addition to these we have used a special law of variation of Hubble parameter proposed by Berman that yields constant deceleration parameter. For two different values of the constant deceleration parameters we have obtained two different cosmological models. The physical behaviors of both the models have been discussed by using some physical parameters.

  16. Constraints on Deceleration Parameter of a 5D Bounce Cosmological Model from Recent Cosmic Observations

    Institute of Scientific and Technical Information of China (English)

    LI Jie-Chao; XU Li-Xin; L(U) Jian-Bo; CHANG Sao-Rong; LIU Hong-Ya

    2008-01-01

    We study the constraint on deceleration parameter q from the recent SNeIa Gold dataset and observational Hubble data by using a model-independent deceleration parameter q(z)=1/2-a/(1+z)b under the five-dimensional bounce cosmological model.For the cases of SNeIa Gold dataset,Hubble data,and their combination,the present results cosmological.For the cases of SNeIa Cold dataset,and their combintion,the present results show that the constraints on transition redshift zT are 0.35+0.14-0.07,0.68+1.47-0.58,and 0.55+0.18-0.09 with lo errors,respectively.

  17. Sensitivity analysis of helicopter IMC decelerating steep approach and landing performance to navigation system parameters

    Science.gov (United States)

    Karmali, M. S.; Phatak, A. V.

    1982-01-01

    Results of a study to investigate, by means of a computer simulation, the performance sensitivity of helicopter IMC DSAL operations as a function of navigation system parameters are presented. A mathematical model representing generically a navigation system is formulated. The scenario simulated consists of a straight in helicopter approach to landing along a 6 deg glideslope. The deceleration magnitude chosen is 03g. The navigation model parameters are varied and the statistics of the total system errors (TSE) computed. These statistics are used to determine the critical navigation system parameters that affect the performance of the closed-loop navigation, guidance and control system of a UH-1H helicopter.

  18. Oscillating dark energy model in plane symmetric space-time with time periodic varying deceleration parameter

    Science.gov (United States)

    She, M.; Jiang, L. P.

    2014-12-01

    In this paper, an oscillating dark energy model is presented in an isotropic but inhomogeneous plane symmetric space-time by considering a time periodic varying deceleration parameter. We find three different types of new solutions which describe different scenarios of oscillating universe. The first two solutions show an oscillating universe with singularities. For the third one, the universe is singularity-free during the whole evolution. Moreover, the Hubble parameter oscillates and keeps positive which explores an interesting possibility to unify the early inflation and late time acceleration of the universe.

  19. Sensitivity analysis of helicopter IMC decelerating steep approach and landing performance to navigation system parameters. [Instrument Meteorological Conditions

    Science.gov (United States)

    Karmali, M. S.; Phatak, A. V.; Bull, J. S.; Peach, L. L.; Demko, P. S.

    1984-01-01

    The present investigation is concerned with a sensitivity analysis of the Decelerated Steep Approach and Landing (DSAL) maneuver to on-board and ground-based navigation system parameters. The Instrument Meteorological Conditions (IMC) DSAL maneuver involves decelerating to zero range rate while tracking the localizer and glideslope. The considered study investigated the performance of the navigation systems using Constant Deceleration Profile (CDP) guidance and a six degrees glideslope trajectory. A closed-loop computer simulation of the UH1H helicopter DSAL system was developed for the sensitivity analysis. Conclusions on system performance parameter sensitivity are discussed.

  20. Probing kinematics and fate of the Universe with linearly time-varying deceleration parameter

    OpenAIRE

    Dereli, Tekin; Akarsu, Özgür; Kumar, Suresh; Xu, Lixin

    2013-01-01

    arXiv:1305.5190v3 [gr-qc] 4 Feb 2014 Probing kinematics and fate of the Universe with linearly time-varying deceleration parameter Özgür Akarsua, Tekin Derelia, Suresh Kumarb, Lixin Xuc a Department of Physics, Koç University, 34450 Sarıyer, İstanbul, Turkey. b Department of Mathematics, BITS Pilani, Pilani Campus, Rajasthan-333031, India. c Institute of Theoretical Physics, Dalian University of Technology, Dalian, 116024, P. R. China. E-Mail: , tdereli@k...

  1. Bianchi Type-II inflationary models with constant deceleration parameter in general relativity

    Indian Academy of Sciences (India)

    C P Singh; S Kumar

    2007-05-01

    Einstein's field equations are considered for a locally rotationally symmetric Bianchi Type-II space–time in the presence of a massless scalar field with a scalar potential. Exact solutions of scale factors and other physical parameters are obtained by using a special law of variation for Hubble's parameter that yields a constant value of deceleration parameter. To get inflationary solutions, a flat region is considered in which the scalar potential is constant. Power-law and exponential cases are studied and in both solutions there is an anisotropic expansion of the cosmic fluid, but the fluid has vanishing vorticity. A detailed study of geometrical and kinematical properties of solutions has been carried out.

  2. HUBBLE PARAMETER MEASUREMENT CONSTRAINTS ON THE COSMOLOGICAL DECELERATION-ACCELERATION TRANSITION REDSHIFT

    Energy Technology Data Exchange (ETDEWEB)

    Farooq, Omer; Ratra, Bharat, E-mail: omer@phys.ksu.edu, E-mail: ratra@phys.ksu.edu [Department of Physics, Kansas State University, 116 Cardwell Hall, Manhattan, KS 66506 (United States)

    2013-03-20

    We compile a list of 28 independent measurements of the Hubble parameter between redshifts 0.07 {<=} z {<=} 2.3 and use this to place constraints on model parameters of constant and time-evolving dark energy cosmologies. These H(z) measurements by themselves require a currently accelerating cosmological expansion at about, or better than, 3{sigma} confidence. The mean and standard deviation of the six best-fit model deceleration-acceleration transition redshifts (for the three cosmological models and two Hubble constant priors we consider) are z{sub da} = 0.74 {+-} 0.05, in good agreement with the recent Busca et al. determination of z{sub da} = 0.82 {+-} 0.08 based on 11 H(z) measurements between redshifts 0.2 {<=} z {<=} 2.3, almost entirely from baryon-acoustic-oscillation-like data.

  3. Binned Hubble parameter measurements and the cosmological deceleration-acceleration transition

    CERN Document Server

    Farooq, Omer; Ratra, Bharat

    2013-01-01

    Weighted mean and median statistics techniques are used to combine 23 independent lower redshift, $z<1.04$, Hubble parameter, $H(z)$, measurements and determine binned forms of $H(z)$. When these are combined with 5 higher redshift, $1.3\\leqslant z \\leqslant 2.3$, $H(z)$ measurements the resulting constraints on cosmological parameters, of three cosmological models, that follow from the weighted-mean binned data are almost identical to those derived from analyses using the 28 independent $H(z)$ measurements. This is consistent with what is expected if the lower redshift measurements errors are Gaussian. Plots of the binned weighted-mean $H(z)/(1+z)$ versus $z$ data are consistent with the presence of a cosmological deceleration-acceleration transition at redshift $z_{\\rm da}=0.74 \\pm 0.05$ \\citep{farooq3}, which is expected in cosmological models with present-epoch energy budget dominated by dark energy as in the standard spatially-flat $\\Lambda$CDM cosmological model.

  4. Bianchi Type-V Bulk Viscous Cosmic String in f(R,T Gravity with Time Varying Deceleration Parameter

    Directory of Open Access Journals (Sweden)

    Bïnaya K. Bishi

    2015-01-01

    Full Text Available We study the Bianchi type-V string cosmological model with bulk viscosity in f(R,T theory of gravity by considering a special form and linearly varying deceleration parameter. This is an extension of the earlier work of Naidu et al., 2013, where they have constructed the model by considering a constant deceleration parameter. Here we find that the cosmic strings do not survive in both models. In addition we study some physical and kinematical properties of both models. We observe that in one of our models these properties are identical to the model obtained by Naidu et al., 2013, and in the other model the behavior of these parameters is different.

  5. Observational constraints on the kinematics and the fate of the Universe through linearly varying deceleration parameter laws

    CERN Document Server

    Akarsu, Ozgur; Kumar, Suresh; Xu, Lixin

    2014-01-01

    We study linearly varying deceleration parameter in terms of cosmic time t (LVDPt) with the companion linearly varying deceleration parameter in terms of cosmic redshift z (LVDPz) and in terms of cosmic scale factor a (LVDPa). We investigate in detail the kinematics and the fate of the Universe by confronting the three LVDP laws with the latest observational data from H(z) compilation (25 data points) and SN Ia Union2.1 compilation (580 data points). The study reveals that the LVDPt law is superior than LVDPz and LVDPa laws in many aspects. In particular, the goodness of fit to the observational data is found to be the best for the LVDPt law. The kinematics and dynamics (assuming general relativity) of the Universe is further studied by considering the LVDPt law in comparison with the standard LCDM model. It is found that these two models are observationally indistinguishable but the LVDPt fits the data slightly better than the LCDM model. These two models exhibit a very similar behavior for a long passage of...

  6. The Hubble diagram of metal-rich QSOs and deceleration parameter q0

    Institute of Scientific and Technical Information of China (English)

    XIE; Guangzhong(

    2001-01-01

    [1]Kristian, J. , Sandage, A. R. , Westphal, J., The extension of the Hubble diagram: Ⅱ. New redshifts and photometry of very distant galaxy clusters, Astrophys. J., 1978, 221: 383.[2]Sandage, A., The redshift-distant relation V. Galaxy co lors as functions of galactic latitude and redshift, Astrophys, J.,1973, 183: 711.[3]Qu, Q. Y., Qin, Z. H., Han, C. S. et al., A relation between magnitudes and redshifts of QSOs with strong interplanetary scientillation, Chinese Astron., 1979, 4: 97.[4]Tinsley, B. M. , The Galaxy counts, color-redshift relation, and related quantities as probes of cosmology and galactic evolu-tion, Astrophys. J., 1977, 211: 621.[5]Spinrad, H., Djorgovski, S., The status of the Hubble diagram in 1986 (eds. Hewitt, A. Burbidge, G. Fang, L. Z. ),Proc. IAU Symp 124 on Observational Cosmology, New York: D. Reidel Publishing Company, 1986, 129.[6]Fang, L. Z., Zhou, Y. Y., Cheng F. Z. et al., Evolution of quasars with resolved components and determination of decel-eration parameter q0, Scientia Sinica, 1979, 22: 1292.[7]Cheng, K. S., Fan, J. H., Li, Y. et al., Do γ-ray burst associated with metal-rich quasars (ed. Cheng, K. S., Singh,H. P.), Proc. of The Pacific Rim Conference on Stellar Astrophysics, August 13-16, 1997, Houg Kong, 1997.[8]Davis, M., Geller, M. J., Huchra, J., The local mean mass density of the universe: new methods for studying galaxy clus-tering, Astrophys. J., 1978, 221: 1.[9]Gott, J. R., Turner, E. L., The mean luminosity and mass densities in the universe, Astrophys. J., 1976, 209: 1.[10]Shapiro, S. L., The density of matter in the form of galaxies, Astron. J., 1971, 76: 291.[11]Fang, L. Z., Hu, F. X., The large-scale inhomogeneities in the universe (eds. Yang, J., Zhu, C. S. ), Proceeding of A-cademia Sinica--Max-Plank Socity Workshop on High Energy Astrophyics Held in Nanjing, China, April 9-17, 1982,New York: Gordon and Breach Science Publishers S.A. 1982, 425[12]Baldwin, J. A

  7. ELENA decelerator

    CERN Multimedia

    2016-01-01

    Footage taken during the preparation of the ELENA decelerator. With a circumference of about 30 m, ELENA can be located in the AD hall where assembly and commissioning would not disturb the current AD operation.

  8. Hubble parameter measurement constraints on the redshift of the deceleration-acceleration transition, dynamical dark energy, and space curvature

    CERN Document Server

    Farooq, Omer; Crandall, Sara; Ratra, Bharat

    2016-01-01

    We compile an updated list of 28 independent measurements of the Hubble parameter $H(z)$ between redshifts $0.1 \\leq z \\leq 2.36$ and use them to place constraints on model parameters of constant and time-varying dark energy cosmological models, both spatially flat and curved. We use five models to measure the redshift of the cosmological deceleration-acceleration transition, $z_{\\rm da}$, from these $H(z)$ data. Within the error bars, the measured $z_{\\rm da}$ are insensitive to the model used, depending only on the value assumed for the Hubble constant $H_0$. The weighted mean of our measurements is $z_{\\rm da} = 0.74 \\pm 0.06\\ (0.86 \\pm 0.04)$ for $H_0 = 68 \\pm 2.8\\ (73.8 \\pm 2.4)$ km s$^{-1}$ Mpc$^{-1}$ and should provide a reasonably model-independent estimate of this cosmological parameter. The $H(z)$ data are consistent with the standard spatially-flat $\\Lambda$CDM cosmological model but do not rule out non-flat models or dynamical dark energy models.

  9. Bianchi Type-II String Cosmological Models in Normal Gauge for Lyra's Manifold with Constant Deceleration Parameter

    CERN Document Server

    Agarwal, Shilpi; Pradhan, Anirudh

    2010-01-01

    The present study deals with a spatially homogeneous and anisotropic Bianchi-II cosmological models representing massive strings in normal gauge for Lyra's manifold by applying the variation law for generalized Hubble's parameter that yields a constant value of deceleration parameter. The variation law for Hubble's parameter generates two types of solutions for the average scale factor, one is of power-law type and other is of the exponential form. Using these two forms, Einstein's modified field equations are solved separately that correspond to expanding singular and non-singular models of the universe respectively. The energy-momentum tensor for such string as formulated by Letelier (1983) is used to construct massive string cosmological models for which we assume that the expansion ($\\theta$) in the model is proportional to the component $\\sigma^{1}_{~1}$ of the shear tensor $\\sigma^{j}_{i}$. This condition leads to $A = (BC)^{m}$, where A, B and C are the metric coefficients and m is proportionality cons...

  10. 公路视错觉减速标线参数优化%Parameter optimization of highway optical illusion deceleration markings

    Institute of Scientific and Technical Information of China (English)

    刘浩学; 刘嘉; 赵炜华; 颜先华; 阎莹

    2011-01-01

    为提高道路危险路段运营安全水平,促使驾驶人主动降低车辆运行速度至安全范围,对比并优化了减速标线的形式及设计参数。依据人在动态环境下视错觉减速标线作用机理,对鱼刺形视错觉减速标线各设计参数进行分析和初选,并提出变间距减速标线相隔距离的计算方法。将不同设计参数进行组合,依据正交试验方案,利用仿真试验平台和实际道路试验,对比各种形式标线的实际减速效果。研究表明:不同设计参数的鱼刺形减速标线,其实际减速效果有很大差异,合理的参数设计方能产生良好的减速效果;与等间距标线相比,变间距减速标线的减速效果更优。%In order to improve the level of operation security in dangerous road sections,the speed should be slowed down to a safe range.The forms and design parameters of the deceleration markings was compared and optimized.Based on the mechanism of optical illusion deceleration markings in dynamic environment,the parameters of the chevron markings were analyzed and the space calculation method was proposed.The different design parameters were combined together to execute the orthogonal experiment.The simulation test and the actual road test were carried out to verify the actual deceleration effects.The results show that the actual deceleration is effected significantly by the design parameters,and good deceleration effects are subject to reasonable parameters design.The deceleration effects of variable spaced deceleration markings are better than the equal ones.

  11. Deceleration Orbit Improvements

    Energy Technology Data Exchange (ETDEWEB)

    Church, M.

    1991-04-26

    During the accelerator studies period of 12/90-1/91 much study time was dedicated to improving the E760 deceleration ramps. 4 general goals were in mind: (1) Reduce the relative orbit deviations from the nominal reference orbit as much as possible. This reduces the potential error in the orbit length calculation - which is the primary source of error in the beam energy calculation. (2) Maximize the transverse apertures. This minimizes beam loss during deceleration and during accidental beam blow-ups. (3) Measure and correct lattice parameters. Knowledge of {gamma}{sub T}, {eta}, Q{sub h}, Q{sub v}, and the dispersion in the straight sections allows for a more accurate energy calculation and reliable SYNCH calculations. (4) Minimize the coupling. This allows one to discern between horizontal and vertical tunes.

  12. Impact parameter dependent electron capture by decelerated U{sup 91+} ions at 20 MeV/u using crystal channeling conditions

    Energy Technology Data Exchange (ETDEWEB)

    Dauvergne, D. E-mail: d.dauvergne@ipnl.in2p3.fr; Braeuning-Demian, A.; Bosch, F.; Braeuning, H.; Chevallier, M.; Cohen, C.; Gumberidze, A.; L' Hoir, A.; Kirsch, R.; Kozhuharov, C.; Liesen, D.; Mokler, P.H.; Poizat, J.C.; Ray, C.; Stoehlker, Th.; Tarisien, M.; Testa, E.; Toleikis, S.; Toulemonde, M

    2003-05-01

    We present results of an experiment using decelerated U{sup 91+} ions, extracted from the GSI-ESR storage ring, and transmitted through a thin silicon crystal in channeling conditions. Charge state at emergence, secondary electron multiplicity and X-rays are measured simultaneously. These conditions allow to study the competition between mechanical electron capture (MEC) and radiative electron capture (REC) as a function of impact parameter. We observe that REC is the dominant charge exchange process for the best channeled ions, i.e. those travelling always far from the silicon target core electrons. For ions with high transverse energy, MEC into highly excited states is counterbalanced by enhanced ionization arising from a succession of close collisions along atomic rows.

  13. Aerocapture Inflatable Decelerator (AID)

    Science.gov (United States)

    Reza, Sajjad

    2007-01-01

    Forward Attached Inflatable Decelerators, more commonly known as inflatable aeroshells, provide an effective, cost efficient means of decelerating spacecrafts by using atmospheric drag for aerocapture or planetary entry instead of conventional liquid propulsion deceleration systems. Entry into planetary atmospheres results in significant heating and aerodynamic pressures which stress aeroshell systems to their useful limits. Incorporation of lightweight inflatable decelerator surfaces with increased surface-area footprints provides the opportunity to reduce heat flux and induced temperatures, while increasing the payload mass fraction. Furthermore, inflatable aeroshell decelerators provide the needed deceleration at considerably higher altitudes and Mach numbers when compared with conventional rigid aeroshell entry systems. Inflatable aeroshells also provide for stowage in a compact space, with subsequent deployment of a large-area, lightweight heatshield to survive entry heating. Use of a deployable heatshield decelerator not only enables an increase in the spacecraft payload mass fraction and but may also eliminate the need for a spacecraft backshell and cruise stage. This document is the viewgraph slides for the paper's presentation.

  14. Study on Train Braking Deceleration Feedback Control Based on Adaptive Parameter Estimation%基于自适应参数估计的列车制动减速度控制

    Institute of Scientific and Technical Information of China (English)

    吴萌岭; 罗卓军

    2015-01-01

    Based on an adaptive parameter estimation method ,a novel deceleration feedback controller was devel‐oped to deal with the uncertain parameters during the braking process of a train ,which have significant influ‐ence on the actual braking deceleration .The novel deceleration feedback controller was verified via a hardware‐in‐the‐loop semi‐physical simulation test bench . Test results suggested that the novel deceleration feedback controller was able to effectively improve the robustness of the brake control system to the uncertain parame‐ters of the train operation .The deceleration feedback controller was able to calculate the actual value of the friction coefficient of a brake shoe w hen the actual friction coefficient of the brake shoe deviated from the preset value in the brake control system ,thereby improving the tracking performance of the actual braking decelera‐tion to target deceleration .When a train was running on a track with slope gradient between ± 30‰ ,the decel‐eration feedback controller calculated the gradient value correctly .Deceleration tracking error reduced from ± 0 .3 m/s2 to ± 0 .1 m/s2 compared with the conventional controllers .The deceleration feedback controller managed the braking performance of the conventional controllers without using the pressure information from the air spring to calculate the brake weight of a train ,which facilitated the redesign of the pneumatic hardware of the brake system .%针对列车制动实际减速度有重要影响的不确定参数,提出基于自适应参数估计的新型减速度控制模式。通过硬件在环半实物仿真试验平台进行试验验证。试验结果表明新型减速度控制算法有效提高了制动控制系统对列车运行不确定参数的鲁棒性。当实际闸瓦摩擦系数偏离制动控制系统预设值时,减速度控制器可以估计出闸瓦摩擦系数的实际值,提高了实际减速度对目标减速度的跟踪效果

  15. The Antiproton Decelerator

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    A technician works on the Antiproton Decelerator (AD) ring. This machine slows down antiprotons so that they can combine with anti-electrons (positrons) and produce anti-hydrogen. Experiments are set up on the AD to attempt to store antihydrogen and investigate properties of anti-hydrogen, such as its mass.

  16. Infrared propagator corrections for constant deceleration

    Energy Technology Data Exchange (ETDEWEB)

    Janssen, T M; Miao, S P; Prokopec, T [Institute for Theoretical Physics and Spinoza Institute, Utrecht University, Leuvenlaan 4, Postbus 80.195, 3508 TD Utrecht (Netherlands); Woodard, R P [Department of Physics, University of Florida Gainesville, FL 32611 (United States)], E-mail: T.M.Janssen@uu.nl, E-mail: S.Miao@uu.nl, E-mail: T.Prokopec@uu.nl, E-mail: woodard@phys.ufl.edu

    2008-12-21

    We derive the propagator for a massless, minimally coupled scalar on a D-dimensional, spatially flat, homogeneous and isotropic background with arbitrary constant deceleration parameter. Our construction uses the operator formalism by integrating the Fourier mode sum. We give special attention to infrared corrections from the nonzero lower limit associated with working on finite spatial sections. These corrections eliminate infrared divergences that would otherwise be incorrectly treated by dimensional regularization, resulting in off-coincidence divergences for those special values of the deceleration parameter at which the infrared divergence is logarithmic. As an application we compute the expectation value of the scalar stress-energy tensor.

  17. Jet propagation and deceleration

    CERN Document Server

    Perucho, Manel

    2013-01-01

    Extragalactic jets in active galactic nuclei (AGN) are divided into two morphological types, namely Fanaroff-Riley I (FRI) and Fanaroff-Riley II (FRII). The former show decollimated structure at the kiloparsec scales and are thought to be decelerated by entrainment within the first kiloparsecs of evolution inside the host galaxy. The entrainment and deceleration can be, at least partly, due to the interaction of jets with stellar winds and gas clouds that enter in the jet as they orbit around the galactic centre. In this contribution, I review recent simulations to study the dynamic effect of entrainment from stellar winds in jets and the direct interaction of jets with gas clouds and stellar winds. I also briefly describe the importance of these interactions as a possible scenario of high-energy emission from extragalactic jets.

  18. Antiproton-Decelerator (AD)

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    When the Low-Energy Antiproton Ring (LEAR) was stopped in 1996, because of its costly operation, a cheaper way of continuing low-energy antiproton physics was sought. The Antiproton-Collector (AC), added in 1987 to the Antiproton Accumulator (AA) to provide a tenfold intensity increase, was converted into the Antiproton-Decelerator (AD). Antiprotons from the target at 3.5 GeV/c are decelerated to 100 MeV/c, and fast-ejected to the experiments. Major changes were necessary. Above all, the conversion from a constant-field machine to one with a magnetic cycle, modulating the field by an impressive factor 35. New systems for stochastic and electron cooling had to be added. Beam diagnostics at an intensity of only 2E7 antiprotons was a challenge. In 2000, the AD began delivery of antiprotons to the experiments.

  19. Regarding the Deceleration of the Universe

    OpenAIRE

    Steinhardt, Paul J.

    1996-01-01

    A proposed strategy for determining the deceleration parameter entails measuring the deviation from a linear (Hubble) distance-red shift relation. However, even at moderate red shifts, z > 0.2, the deviation does not depend on q_0 alone, but also on the equation-of-state of the universe.

  20. Basic MR sequence parameters systematically bias automated brain volume estimation

    Energy Technology Data Exchange (ETDEWEB)

    Haller, Sven [University of Geneva, Faculty of Medicine, Geneva (Switzerland); Affidea Centre de Diagnostique Radiologique de Carouge CDRC, Geneva (Switzerland); Falkovskiy, Pavel; Roche, Alexis; Marechal, Benedicte [Siemens Healthcare HC CEMEA SUI DI BM PI, Advanced Clinical Imaging Technology, Lausanne (Switzerland); University Hospital (CHUV), Department of Radiology, Lausanne (Switzerland); Meuli, Reto [University Hospital (CHUV), Department of Radiology, Lausanne (Switzerland); Thiran, Jean-Philippe [LTS5, Ecole Polytechnique Federale de Lausanne, Lausanne (Switzerland); Krueger, Gunnar [Siemens Medical Solutions USA, Inc., Boston, MA (United States); Lovblad, Karl-Olof [University of Geneva, Faculty of Medicine, Geneva (Switzerland); University Hospitals of Geneva, Geneva (Switzerland); Kober, Tobias [Siemens Healthcare HC CEMEA SUI DI BM PI, Advanced Clinical Imaging Technology, Lausanne (Switzerland); LTS5, Ecole Polytechnique Federale de Lausanne, Lausanne (Switzerland)

    2016-11-15

    Automated brain MRI morphometry, including hippocampal volumetry for Alzheimer disease, is increasingly recognized as a biomarker. Consequently, a rapidly increasing number of software tools have become available. We tested whether modifications of simple MR protocol parameters typically used in clinical routine systematically bias automated brain MRI segmentation results. The study was approved by the local ethical committee and included 20 consecutive patients (13 females, mean age 75.8 ± 13.8 years) undergoing clinical brain MRI at 1.5 T for workup of cognitive decline. We compared three 3D T1 magnetization prepared rapid gradient echo (MPRAGE) sequences with the following parameter settings: ADNI-2 1.2 mm iso-voxel, no image filtering, LOCAL- 1.0 mm iso-voxel no image filtering, LOCAL+ 1.0 mm iso-voxel with image edge enhancement. Brain segmentation was performed by two different and established analysis tools, FreeSurfer and MorphoBox, using standard parameters. Spatial resolution (1.0 versus 1.2 mm iso-voxel) and modification in contrast resulted in relative estimated volume difference of up to 4.28 % (p < 0.001) in cortical gray matter and 4.16 % (p < 0.01) in hippocampus. Image data filtering resulted in estimated volume difference of up to 5.48 % (p < 0.05) in cortical gray matter. A simple change of MR parameters, notably spatial resolution, contrast, and filtering, may systematically bias results of automated brain MRI morphometry of up to 4-5 %. This is in the same range as early disease-related brain volume alterations, for example, in Alzheimer disease. Automated brain segmentation software packages should therefore require strict MR parameter selection or include compensatory algorithms to avoid MR parameter-related bias of brain morphometry results. (orig.)

  1. Volume variation of Gruneisen parameters of fcc transition metals

    Indian Academy of Sciences (India)

    C V Pandya; P R Vyas; T C Pandya; V B Gohel

    2002-02-01

    The volume variation of the Gruneisen parameters of ten fcc transition metals, up to 40% compression, has been studied on the basis of a model approach proposed by Antonov et al. The results are reasonably good for six metals except for Rh, Ag, Au and Ni when compared with available experimental and other theoretical values. The model requires an appropriate modification for Rh, Ag, Au and Ni.

  2. Multipinhole SPECT helical scan parameters and imaging volume

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Rutao, E-mail: rutaoyao@buffalo.edu; Deng, Xiao [Department of Nuclear Medicine, State University of New York at Buffalo, Buffalo, New York 14214 (United States); Wei, Qingyang; Dai, Tiantian; Ma, Tianyu [Department of Engineering Physics, Tsinghua University, Beijing 100084 (China); Lecomte, Roger [Department of Nuclear Medicine and Radiobiology, Sherbrooke Molecular Imaging Center, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4 (Canada)

    2015-11-15

    Purpose: The authors developed SPECT imaging capability on an animal PET scanner using a multiple-pinhole collimator and step-and-shoot helical data acquisition protocols. The objective of this work was to determine the preferred helical scan parameters, i.e., the angular and axial step sizes, and the imaging volume, that provide optimal imaging performance. Methods: The authors studied nine helical scan protocols formed by permuting three rotational and three axial step sizes. These step sizes were chosen around the reference values analytically calculated from the estimated spatial resolution of the SPECT system and the Nyquist sampling theorem. The nine helical protocols were evaluated by two figures-of-merit: the sampling completeness percentage (SCP) and the root-mean-square (RMS) resolution. SCP was an analytically calculated numerical index based on projection sampling. RMS resolution was derived from the reconstructed images of a sphere-grid phantom. Results: The RMS resolution results show that (1) the start and end pinhole planes of the helical scheme determine the axial extent of the effective field of view (EFOV), and (2) the diameter of the transverse EFOV is adequately calculated from the geometry of the pinhole opening, since the peripheral region beyond EFOV would introduce projection multiplexing and consequent effects. The RMS resolution results of the nine helical scan schemes show optimal resolution is achieved when the axial step size is the half, and the angular step size is about twice the corresponding values derived from the Nyquist theorem. The SCP results agree in general with that of RMS resolution but are less critical in assessing the effects of helical parameters and EFOV. Conclusions: The authors quantitatively validated the effective FOV of multiple pinhole helical scan protocols and proposed a simple method to calculate optimal helical scan parameters.

  3. Deceleration without dark matter

    CERN Document Server

    Jackson, J C; Dodgson, Marina

    1997-01-01

    Despite its title, a prominent conclusion is that if the Universe is spatially flat, then the best cosmological parameters are Omega_m=0.2, Omega_Lambda=0.8, with probable range 0.1parameters of the model. It has been argued that as a population ultracompact (milliarcsecond) radio sources measured by very long-baseline interferometry (VLBI) do not evolve with cosmic epoch, and thus comprise a set of standard objects, at least in a statistical sense. Here we examine the angular-size/redshift relation for 256 ultracompact sources with z in the range 0.5 to 3.8 for cosmological models with two degrees of freedom (Omega_0 and Lambda_0). The canonical inflationary cold dark matter model(Omega_0=1, Lambda_0=0) app...

  4. The Correlation between Ultrasound Testicular Volume and Conventional Semen Parameters in Albanian Subfertile Males

    Directory of Open Access Journals (Sweden)

    Adrian Kristo

    2014-09-01

    CONCLUSION: Testicular volume has a direct correlation with semen parameters and the critical total testicular volume indicating normal testicular function is approximately 26.6 ml (the mean testicular volume 13.3 ml. The measurement of testicular volume can be helpful for assessing fertility at the initial physical examination.

  5. A Flight Investigation of Control, Display, and Guidance Requirements for Decelerating Descending VTOL Instrument Transitions using the X-22A Variable Stability Aircraft. Volume 1. Technical Discussion and Results

    Science.gov (United States)

    1975-09-01

    airspeed/ground speed switching logic, configuration change command. 5.0 Selection of control system types , individual system characteristics...all five control system types in combination with the three most sophisticated display presentations is intended to provide some guidance in...deceleration profiles. 2. The required dynamic characteristics of the generic control system types investigated in this experiment should be

  6. Impact of the Road Profile on Vehicle Deceleration

    Directory of Open Access Journals (Sweden)

    Vidas Žuraulis

    2012-11-01

    Full Text Available The article analyzes the impact of the longitudinal road profile on the efficiency of car braking estimated applying deceleration value. Different formulas are used for theoretical calculations, and therefore experimental brakes in different road slopes were performed to obtain the most accurate results. Deceleration, as one of the most important safety parameters, depends on the technical condition of the braking system, road conditions and structural and dynamic properties of the other car. Road alignments can significantly affect car manageability, because of weight transfer and extra track resistance, which may change the overall balance of the car and affect the nature of dynamic characteristics that may vary from certain critical values. The results of corrections to deceleration dependence on the road profile can be used for investigating traffic accidents, optimizing traffic control arrangements and implementing advanced systems for automotive active safety.

  7. Advanced switching schemes in a Stark decelerator

    CERN Document Server

    Zhang, Dongdong; Meijer, Gerard

    2015-01-01

    We revisit the operation of the Stark decelerator and present a new, optimized operation scheme, which substantially improves the efficiency of the decelerator at both low and high final velocities, relevant for trapping experiments and collision experiments, respectively. Both experimental and simulation results show that this new mode of operation outperforms the schemes which have hitherto been in use. This new mode of operation could potentially be extended to other deceleration techniques.

  8. Hypersonic Inflatable Aerodynamic Decelerator (HIAD) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Hypersonic Inflatable Aerodynamic Decelerator (HIAD) project will focus on the development and demonstration of hypersonic inflatable aeroshell technologies...

  9. Deceleration system for kinematic linkages of positioning

    Science.gov (United States)

    Stan, G.

    2017-08-01

    Flexible automation is used more and more in various production processes, so that both machining itself on CNC machine tools and workpiece handling means are performed through programming the needed working cycle. In order to obtain a successful precise positioning, each motion degree needs a certain deceleration before stopping at a programmed point. The increase of motion speed of moving elements within the manipulators structure depends directly on deceleration duty quality before the programmed stop. Proportional valves as well as servo-valves that can perform hydraulic decelerations are well known, but they feature several disadvantages, such as: high price, severe conditions for oil filtering and low reliability under industrial conditions. This work presents a new deceleration system that allows adjustment of deceleration slope according to actual conditions: inertial mass, speed etc. The new solution of hydraulic decelerator allows its integration to a position loop or its usage in case of positioning large elements that only perform fixed cycles. The results being obtained on the positioning accuracy of a linear axis using the new solution of the hydraulic decelerator are presented, too. The price of the new deceleration system is much lower compared to the price of proportional valves or servo-valves.

  10. Estimating deep seafloor interface and volume roughness parameters using the multibeam-hydrosweep system

    Digital Repository Service at National Institute of Oceanography (India)

    Chakraborty, B.; Schenke, H.W.; Kodagali, V.N.; Hagen, R.

    composite roughness model, including water-sediment interface roughness and sediment volume roughness parameters the data was modeled. The model effectively uses the near normal incidence angle backscatter to determine the seafloor interface roughness...

  11. Physics at CERN's Antiproton Decelerator

    CERN Document Server

    Hori, M

    2013-01-01

    The Antiproton Decelerator of CERN began operation in 1999 to serve experiments for studies of CPT invariance by precision laser and microwave spectroscopy of antihydrogen ($\\bar{\\rm H}$) and antiprotonic helium ($\\bar{p}{\\rm He}^+$). The first 12 years of operation saw cold $\\bar{\\rm H}$ synthesized by overlapping clouds of positrons ($e^+$) and antiprotons ($\\bar{p}$) confined in magnetic Penning traps. Cold $\\bar{\\rm H}$ was also produced in collisions between Rydberg positronium atoms and $\\bar{p}$. Ground-state $\\bar{\\rm H}$ was later trapped for up to $\\sim 1000$ s in a magnetic bottle trap, and microwave transitions excited between its hyperfine levels. In the $\\bar{p}{\\rm He}^+$ atom, UV transitions were measured to a precision of (2.3-5) $\\times$ $10^{-9}$ by sub-Doppler two-photon laser spectroscopy. From this the antiproton-to-electron mass ratio was determined as $M_{\\bar{p}}/m_e=$1836.1526736(23), which agrees with the p value. Microwave spectroscopy of $\\bar{p}{\\rm He}^+$ yielded a measurement o...

  12. Reference values for frequency volume chart and uroflowmetry parameters in adolescent and adult enuresis patients

    NARCIS (Netherlands)

    Hofmeester, Ilse; Brinker, Astrid E.; Steffens, Martijn G.; Mulder, Zwaan; van Capelle, Jan Willem; Feitz, Wout F.J.; Blanker, Marco H.

    2017-01-01

    Aims: Reference values of Frequency Volume Chart (FVC) and uroflowmetry parameters for adolescent and adult enuresis patients are lacking. In this study, we aim to describe those parameters, in order to interpret findings from FVCs and uroflowmetries in those patients. Methods: Retrospective, descri

  13. Earth's Decelerating Tectonic Plates

    Energy Technology Data Exchange (ETDEWEB)

    Forte, A M; Moucha, R; Rowley, D B; Quere, S; Mitrovica, J X; Simmons, N A; Grand, S P

    2008-08-22

    Space geodetic and oceanic magnetic anomaly constraints on tectonic plate motions are employed to determine a new global map of present-day rates of change of plate velocities. This map shows that Earth's largest plate, the Pacific, is presently decelerating along with several other plates in the Pacific and Indo-Atlantic hemispheres. These plate decelerations contribute to an overall, globally averaged slowdown in tectonic plate speeds. The map of plate decelerations provides new and unique constraints on the dynamics of time-dependent convection in Earth's mantle. We employ a recently developed convection model constrained by seismic, geodynamic and mineral physics data to show that time-dependent changes in mantle buoyancy forces can explain the deceleration of the major plates in the Pacific and Indo-Atlantic hemispheres.

  14. Earth's Decelerating Tectonic Plates

    Energy Technology Data Exchange (ETDEWEB)

    Forte, A M; Moucha, R; Rowley, D B; Quere, S; Mitrovica, J X; Simmons, N A; Grand, S P

    2008-08-22

    Space geodetic and oceanic magnetic anomaly constraints on tectonic plate motions are employed to determine a new global map of present-day rates of change of plate velocities. This map shows that Earth's largest plate, the Pacific, is presently decelerating along with several other plates in the Pacific and Indo-Atlantic hemispheres. These plate decelerations contribute to an overall, globally averaged slowdown in tectonic plate speeds. The map of plate decelerations provides new and unique constraints on the dynamics of time-dependent convection in Earth's mantle. We employ a recently developed convection model constrained by seismic, geodynamic and mineral physics data to show that time-dependent changes in mantle buoyancy forces can explain the deceleration of the major plates in the Pacific and Indo-Atlantic hemispheres.

  15. The Antiproton Accumulator becomes Antiproton Decelerator

    CERN Multimedia

    1980-01-01

    The photos show the Antiproton Accumulator (AA) transformed into Antiproton Decelerator. The AA was used at CERN between 1981 and 1999 before being replaced by the Antiproton Decelerator (AD). The AA was used to collect and stochastically cool antiprotons used in proton-antiproton collisions in the SPS collider. This lead to the discovery of the W and Z bosons in 1983 and the Nobel Prize for Carlo Rubbia and Simon van der Meer in 1984.

  16. Zeeman-Sisyphus Deceleration of Molecular Beams

    Science.gov (United States)

    Fitch, Noah; Tarbutt, Mike

    2016-05-01

    Ultracold molecules are useful for testing fundamental physics and studying strongly-interacting quantum systems. One production method is via direct laser cooling in a magneto-optical trap (MOT). In this endeavor, one major challenge is to produce molecules below the MOT capture velocity. Established molecular beam deceleration techniques are poorly suited because they decelerate only a small fraction of a typical molecular pulse. Direct laser cooling is a natural choice, but is also problematic due to transverse heating and the associated molecule loss. I will present a new technique that we are developing, which we call Zeeman-Sisyphus deceleration and which shows great promise for preparing molecular beams for MOT loading. This technique decelerates molecules using a linear array of permanent magnets, along with lasers that periodically optically pump molecules between weak and strong-field seeking quantum states. Being time-independent, this method is well-suited for temporally extended molecular beams. Simultaneous deceleration and transverse guiding makes this approach attractive as an alternative to direct laser cooling. I will present our development of the Zeeman-Sisyphus decelerator and its application to a molecular MOT of CaF and an ultracold fountain of YbF.

  17. Protection Parameters against the Cracks by the Method of Volume Compensation Dam

    Directory of Open Access Journals (Sweden)

    Bulatov Georgiy

    2016-01-01

    Full Text Available This article provides estimates the parameters of protection from cracking dam due to volume compensation method. This article discusses the method of compensation dam volume. This method allows calculating the settings of security causing cracks the dam. Presents graphs of horizontal deformations of elongation calculated surface along the length of the construction and in time. Showing horizontal stress distribution diagram in the ground around the pile in plan and in section. Given all the necessary formulas for the method of compensation of the dam volume.

  18. Static Trapping of Polar Molecules in a Traveling Wave Decelerator

    NARCIS (Netherlands)

    Quintero-Perez, Marina; Jansen, Paul; Wall, Thomas E.; van den Berg, Joost E.; Hoekstra, Steven; Bethlem, Hendrick L.

    2013-01-01

    We present experiments on decelerating and trapping ammonia molecules using a combination of a Stark decelerator and a traveling wave decelerator. In the traveling wave decelerator, a moving potential is created by a series of ring-shaped electrodes to which oscillating high voltages (HV) are applie

  19. Model for the overall phase-space acceptance in a Zeeman decelerator

    CERN Document Server

    Dulitz, Katrin; Softley, Timothy P

    2015-01-01

    We present a new formalism to calculate phase-space acceptance in a Zeeman decelerator. Using parameters closely mimicking previous Zeeman deceleration experiments, this approach reveals a hitherto unconsidered velocity dependence of the phase stability which we ascribe to the finite rise and fall times of the current pulses that generate the magnetic fields inside the deceleration coils. It is shown that changing the current switch-off times as the sequence progresses, so as to maintain a constant mean acceleration per pulse, can lead to a constant phase stability and hence a beam with well-defined characteristics. We also find that the time overlap between fields of adjacent coils has an influence on the phase-space acceptance. Previous theoretical and experimental results suggested unfilled regions in phase space that influence particle transmission through the decelerator. Our model provides, for the first time, a means to directly identify the origin of these effects due to coupling between longitudinal ...

  20. Reasons for the weak correlation between prostate volume and urethral resistance parameters in patients with prostatism

    NARCIS (Netherlands)

    J.L.H.R. Bosch (Ruud); R. Kranse (Ries); R. van Mastrigt (Ron); F.H. Schröder (Fritz); W.K. Mebust (W.)

    1995-01-01

    textabstractIn an attempt to increase our understanding of the clinical syndrome of benign prostatic hyperplasia (BPH) an analysis was made of the association between prostate volume as measured by transrectal ultrasound and several reported urodynamically determined urethral resistance parameters.

  1. Zeeman deceleration beyond periodic phase space stability

    Science.gov (United States)

    Toscano, Jutta; Tauschinsky, Atreju; Dulitz, Katrin; Rennick, Christopher J.; Heazlewood, Brianna R.; Softley, Timothy P.

    2017-08-01

    In Zeeman deceleration, time-varying spatially inhomogeneous magnetic fields are used to create packets of translationally cold, quantum-state-selected paramagnetic particles with a tuneable forward velocity, which are ideal for cold reaction dynamics studies. Here, the covariance matrix adaptation evolutionary strategy is adopted in order to optimise deceleration switching sequences for the operation of a Zeeman decelerator. Using the optimised sequences, a 40% increase in the number of decelerated particles is observed compared to standard sequences for the same final velocity, imposing the same experimental boundary conditions. Furthermore, we demonstrate that it is possible to remove up to 98% of the initial kinetic energy of particles in the incoming beam, compared to the removal of a maximum of 83% of kinetic energy with standard sequences. Three-dimensional particle trajectory simulations are employed to reproduce the experimental results and to investigate differences in the deceleration mechanism adopted by standard and optimised sequences. It is experimentally verified that the optimal solution uncovered by the evolutionary algorithm is not merely a local optimisation of the experimental parameters—it is a novel mode of operation that goes beyond the standard periodic phase stability approach typically adopted.

  2. Study of Deceleration Behaviour of Different Vehicle Types

    Directory of Open Access Journals (Sweden)

    Akhilesh Kumar Maurya

    2012-09-01

    Full Text Available Deceleration characteristics of vehicles are important for intersection design, deceleration lane design, traffic simulation modeling, vehicular emission and fuel consumption modeling, etc. Heterogeneous traffic stream consists of vehicles with wide variation in their physical dimensions, weight to power ratio and dynamic characteristics, which affect their deceleration behaviour. Majority of past studies are restricted to deceleration behaviour study of cars and trucks in homogenous traffic. Present study aims to analyze the deceleration behaviour of different vehicles types (like truck, car, motorized two and three-wheeler on Nagpur-Mumbai Express Highway at Wardha, India. Drivers were asked to decelerate their vehicles from their maximum speed to zero speed in shortest time and their speed profiles are collected using Global Positioning System. Deceleration behaviour of different vehicle types is significantly different. Vehicles with higher maximum speed have higher deceleration time, deceleration distance, maximum and mean deceleration rates during their deceleration manoeuvre. In deceleration manoeuvre, vehicle’s deceleration rate initially increases, attains the maximum deceleration and decreases afterwards. A dual regime model is developed to describe deceleration behaviour over entire speed range of all vehicle types except car. For car, a second order polynomial is proposed.

  3. Effect of varicocelectomy on testis volume and semen parameters in adolescents: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Tie Zhou

    2015-01-01

    Full Text Available Varicocele repair in adolescent remains controversial. Our aim is to identify and combine clinical trials results published thus far to ascertain the efficacy of varicocelectomy in improving testis volume and semen parameters compared with nontreatment control. A literature search was performed using Medline, Embase and Web of Science, which included results obtained from meta-analysis, randomized and nonrandomized controlled studies. The study population was adolescents with clinically palpable varicocele with or without the testicular asymmetry or abnormal semen parameters. Cases were allocated to treatment and observation groups, and testis volume or semen parameters were adopted as outcome measures. As a result, seven randomized controlled trials (RCTs and nonrandomized controlled trials studying bilateral testis volume or semen parameters in both treatment and observation groups were identified. Using a random effect model, mean difference of testis volume between the treatment group and the observation group was 2.9 ml (95% confidence interval [CI]: 0.6, 5.2; P< 0.05 for the varicocele side and 1.5 ml (95% CI: 0.3, 2.7; P< 0.05 for the healthy side. The random effect model analysis demonstrated that the mean difference of semen concentration, total semen motility, and normal morphology between the two groups was 13.7 × 10 6 ml−1 (95% CI: −1.4, 28.8; P = 0.075, 2.5% (95% CI: −3.6, 8.6; P= 0.424, and 2.9% (95% CI: −3.0, 8.7; P= 0.336 respectively. In conclusion, although varicocelectomy significantly improved bilateral testis volume in adolescents with varicocele compared with observation cases, semen parameters did not have any statistically significant difference between two groups. Well-planned, properly conducted RCTs are needed in order to confirm the above-mentioned conclusion further and to explore whether varicocele repair in adolescents could improve subsequently spontaneous pregnancy rates.

  4. Will There Be Future Deceleration? A Study of Particle Creation Mechanism in Nonequilibrium Thermodynamics

    Directory of Open Access Journals (Sweden)

    Supriya Pan

    2015-01-01

    Full Text Available The paper deals with nonequilibrium thermodynamics based on adiabatic particle creation mechanism with the motivation of considering it as an alternative choice to explain the recent observed accelerating phase of the universe. Using Friedmann’s equations, it is shown that the deceleration parameter (q can be obtained from the knowledge of the particle production rate (Γ. Motivated by thermodynamical point of view, cosmological solutions are evaluated for the particle creation rates in three cosmic phases, namely, inflation, matter dominated era, and present late time acceleration. The deceleration parameter (q is expressed as a function of the redshift parameter (z, and its variation is presented graphically. Also, statefinder analysis has been presented graphically in three different phases of the universe. Finally, two noninteracting fluids with different particle creation rates are considered as cosmic substratum, and deceleration parameter (q is evaluated. Whether more than one transition of q is possible or not is examined by graphical representations.

  5. Value of three hemodynamic parameters in evaluating volume status under artificial pneumoperitoneum and their correlation

    Directory of Open Access Journals (Sweden)

    Xiao-mei LIU

    2014-08-01

    Full Text Available Objective To explore the value of stroke volume variation (SVV, pulse pressure variation (PPV and pleth variability index (PVI in evaluating the volume status under pneumoperitoneum and their correlation. Methods Twenty-six patients with stomach cancer receiving laparoscopy-assisted radical gastrectomy under general anesthesia were involved in this study. The indexes of SVV, PPV and PVI were monitored continuously after general anesthesia. A volume loading test was performed after pneumoperitoneum, and the hemodynamic parameters were determined before and after fluid infusion (6% HES, 7ml/kg, and the patients were divided into response group (n=16 and non-response group (n=10 according to whether the increase in stroke volume index (ΔSVI was ≥15% or not. The receiver operator characteristic (ROC curves of SVV, PPV and PVI were drawn to evaluate the value of SVV, PPV and PVI in evaluating volume status under artificial pneumoper itoneum and the correlation between them. Results The analysis of ROC curves showed that SVV, PPV and PVI could all be used to estimate the volume status effectively, the area under the curve (AUC of them was 0.978, 0.963 and 0.928 respectively, and there was a significant correlation between the three parameters (SVV and PPV: r=0.921, P<0.01; SVV and PVI: r=0.686, P<0.01; PPV and PVI: r=0.577, P<0.01. Conclusion SVV, PPV and PVI could be used to accurately evaluate the volume status under artificial pneumoperitoneum, and there is a good correlation between them. DOI: 10.11855/j.issn.0577-7402.2014.07.08

  6. Underground Test Area Subproject Phase I Data Analysis Task. Volume IV - Hydrologic Parameter Data Documentation Package

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-09-01

    Volume IV of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the hydrologic parameter data. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

  7. Cervical Vertebral Body’s Volume as a New Parameter for Predicting the Skeletal Maturation Stages

    Directory of Open Access Journals (Sweden)

    Youn-Kyung Choi

    2016-01-01

    Full Text Available This study aimed to determine the correlation between the volumetric parameters derived from the images of the second, third, and fourth cervical vertebrae by using cone beam computed tomography with skeletal maturation stages and to propose a new formula for predicting skeletal maturation by using regression analysis. We obtained the estimation of skeletal maturation levels from hand-wrist radiographs and volume parameters derived from the second, third, and fourth cervical vertebrae bodies from 102 Japanese patients (54 women and 48 men, 5–18 years of age. We performed Pearson’s correlation coefficient analysis and simple regression analysis. All volume parameters derived from the second, third, and fourth cervical vertebrae exhibited statistically significant correlations (P<0.05. The simple regression model with the greatest R-square indicated the fourth-cervical-vertebra volume as an independent variable with a variance inflation factor less than ten. The explanation power was 81.76%. Volumetric parameters of cervical vertebrae using cone beam computed tomography are useful in regression models. The derived regression model has the potential for clinical application as it enables a simple and quantitative analysis to evaluate skeletal maturation level.

  8. Impact of 8-week endurance training on qualitative and quantitative parameters of stroke volume

    Directory of Open Access Journals (Sweden)

    Suzana Pustivšek

    2014-08-01

    Full Text Available Background: Dynamics of stroke volume during increasing progressive load varies widely among individuals. The data of current studies describing the impact of long-term endurance training on the dynamics of cardiac stroke volume are conflicting. The purpose of this study was to evaluate the impact of 8-week endurance training on the dynamics of stroke volume and some quantitative features of cardiac function in recreational female runners.Methods: Measurements were performed in the physiological laboratory at the Institute of Sport, Faculty of Sport in Ljubljana. CosmedK4b2 equipment that allows continuous “on-line”, “breath-by-breath” monitoring of oxygen consumption and gases in exhaled air was used. Cardiac output was calculated by the method described by Stringer et al.Results: The results showed a significant increase in stroke volume at rest and during the first two minutes of the test. Maximum stroke volume did not increase, but there was a decrease in heart rate during maximal stroke volume from 126.65 (± 27.14 to 120.15 (± 26.56 beats per minute. The dynamics of stroke volume in a majority of participants did not change. The most common dynamics of stroke volume before and after test was plateau dynamics. The training resulted in an increase in running endurance and the average increase in running speed during the final test by 4.41 % (± 4.62.Conclusion: The exercise resulted in minimal changes in cardiac function and a significant improvement in endurance parameters.

  9. Deceleration of SS433 radio jets

    CERN Document Server

    Panferov, A A

    2013-01-01

    The mildly relativistic jets of SS\\,433 are believed to inflate the surrounding supernova remnant W\\,50 depositing in its expansion possibly more than 99% of their kinetic energy (\\cite[1998]{Dub98}). Where and how this transformation of energy is curried out, it is not yet known. What can we learn from it that the jets decelerate and the deceleration is non-dissipative, i.e. radiatively dark. In this paper we unclose the observed deviations of the precessing radio jets of SS\\,433, within a few arcseconds from a jets source, from the ballistic track, described by the kinematic model, as a signature of the deceleration which, on other hand, issues from the jets colliding with ambient medium. For that we model kinematics of these colliding jets. The ram pressure on the jets is estimated from the observed profile of brightness of synchrotron radiation along the radio jets. We have found that to fit observed locus the radio jets should be decelerated and twisted, additionally to the precession twist, mostly withi...

  10. Decelerating Flows in TeV Blazars

    CERN Document Server

    Kazanas, M G D

    2004-01-01

    The peak of the de-absorbed energy distribution of the TeV emitting BLs can reach values up to ~10 TeV. In the context of SSC models of relativistic uniformly moving blobs of plasma, such high energy peak emission can be reproduced only by assuming Doppler factors delta ~ 50. However, such high values strongly disagree with the unification of FR I radio galaxies and BLs. Additionally, the recent detections of slow, possibly sub-luminal velocities in the sub-pc scale jets of the TeV BLS MKN 421 and MKN 501 suggest that the jets in these sources decelerate very early to mildly relativistic velocities (Gamma \\~ a few). Here, we examine the possibility that the relativistic flow in the TeV BLs decelerates lognitudinally. In this case, modest Lorentz factors (Gamma~15), decelerating down to values compatible with the recent interferometric observations, can reproduce the ~ few TeV peak energy of these sources. Furthermore, such decelerating flows naturally reproduce the observed broadband BL-FR I luminosity ratios...

  11. Status Report on the Antiproton Decelerator (AD)

    CERN Document Server

    Erikson, T; Möhl, D

    2001-01-01

    CERN's new Antiproton Decelerator (AD) has been delivering a 100 MeV/c antiproton beam to three experiments (ASACUSA, AHENA and ATRAP) since July 10th, 2000. In this status report, we summarise the initial performance of the AD, draw provisional conclusions from the first month of operation and finally give some prospects for the future.

  12. Turbulent pipe flows subjected to temporal decelerations

    Science.gov (United States)

    Jeong, Wongwan; Lee, Jae Hwa

    2016-11-01

    Direct numerical simulations of temporally decelerating turbulent pipe flows were performed to examine effects of temporal decelerations on turbulence. The simulations were started with a fully developed turbulent pipe flow at a Reynolds number, ReD =24380, based on the pipe radius (R) and the laminar centerline velocity (Uc 0). Three different temporal decelerations were imposed to the initial flow with f= | d Ub / dt | =0.00127, 0.00625 and 0.025, where Ub is the bulk mean velocity. Comparison of Reynolds stresses and turbulent production terms with those for steady flow at a similar Reynolds number showed that turbulence is highly intensified with increasing f due to delay effects. Furthermore, inspection of the Reynolds shear stress profiles showed that strong second- and fourth-quadrant Reynolds shear stresses are greatly increased, while first- and third-quadrant components are also increased. Decomposition of streamwise Reynolds normal stress with streamwise cutoff wavelength (λx) 1 R revealed that the turbulence delay is dominantly originated from delay of strong large-scale turbulent structures in the outer layer, although small-scale motions throughout the wall layer adjusted more rapidly to the temporal decelerations. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2014R1A1A2057031).

  13. The relationship between malnutrition subgroups and volume parameters in pre-dialysis patients

    Directory of Open Access Journals (Sweden)

    Dilek Aslan Kutsal

    2016-01-01

    Full Text Available There are two types of malnutrition in patients with chronic renal failure (CRF; type 1 and type 2. The aim of this study was to investigate the relationship between malnutrition and inflammation and also the relationship between malnutrition and volume status. Ninety-four pre-dialysis CRF patients were included in the study. Nutritional status of the patients was calculated using the subjective global assessment. Scores of 1-5 were given according to the severity of the symptoms and physical examination findings. Serum inflammation markers [high-sensitive C-reactive protein (hs-CRP, interleukin-1β, interleukin-6 and tumor necrosis factor-alfa] and nutrition parameters (albumin, pre-albumin, transferrin, fetuin-A, insulin like growth factor-1 and insulin-like growth factor-binding protein-3] were measured in all the patients. Serum N-terminal pro-brain natriuretic peptide levels and echocardiography were performed to evaluate the volume status of the patients. The mean age of the patients was 59.6 ± 13.3 years, the mean malnutrition score was 17.2 ± 6.01, the mean and the median of hs-CRP levels were 18.5 ± 40.7 and 5.6 mg/L, respectively, the mean albumin level was 3.46 ± 0.48 and the mean creatinine clearance was 23.7 ± 13.5 mL/min. A positive correlation between malnutrition scores with inflammation and volume parameters was found in the bivariate and multivariate analysis. In the multiple regression analysis, volume parameters proved to be the most important factors influencing malnutrition scores. Thus, the elimination of volume excess would ameliorate both inflammation and malnutrition. This hypothesis needs to be supported or proved with prospective studies.

  14. The relationship between malnutrition subgroups and volume parameters in pre-dialysis patients.

    Science.gov (United States)

    Kutsal, Dilek Aslan; Kürşat, Seyhun; İnci, Ayça; Ulman, Cevval; OzanÜtük, I

    2016-01-01

    There are two types of malnutrition in patients with chronic renal failure (CRF); type 1 and type 2. The aim of this study was to investigate the relationship between malnutrition and inflammation and also the relationship between malnutrition and volume status. Ninety-four pre-dialysis CRF patients were included in the study. Nutritional status of the patients was calculated using the subjective global assessment. Scores of 1-5 were given according to the severity of the symptoms and physical examination findings. Serum inflammation markers [high-sensitive C-reactive protein (hs-CRP), interleukin-1β, interleukin-6 and tumor necrosis factor-alfa] and nutrition parameters (albumin, pre-albumin, transferrin, fetuin-A, insulin like growth factor-1 and insulin-like growth factor-binding protein-3)] were measured in all the patients. Serum N-terminal pro-brain natriuretic peptide levels and echocardiography were performed to evaluate the volume status of the patients. The mean age of the patients was 59.6±13.3 years, the mean malnutrition score was 17.2±6.01, the mean and the median of hs-CRP levels were 18.5±40.7 and 5.6 mg/L, respectively, the mean albumin level was 3.46±0.48 and the mean creatinine clearance was 23.7±13.5 mL/min. A positive correlation between malnutrition scores with inflammation and volume parameters was found in the bivariate and multivariate analysis. In the multiple regression analysis, volume parameters proved to be the most important factors influencing malnutrition scores. Thus, the elimination of volume excess would ameliorate both inflammation and malnutrition. This hypothesis needs to be supported or proved with prospective studies.

  15. Sonographic Parameters for Prediction of Miscarriage: Role of 3-Dimensional Volume Measurement.

    Science.gov (United States)

    Wie, Jeong Ha; Choe, Suyearn; Kim, Sa Jin; Shin, Jong Chul; Kwon, Ji Young; Park, In Yang

    2015-10-01

    To evaluate the value of volume measurement using 3-dimensional sonography for prediction of miscarriage. We prospectively enrolled 188 singleton pregnant women at 5 to 9 weeks' gestation. The 3-dimensional sonographic gestational sac volume and yolk sac volume were measured together with the fetal heart rate, gestational sac diameter, and yolk sac diameter. For each sonographic parameter, nomograms were created; z scores were calculated for each measurement, and the values were compared between miscarriage and ongoing pregnancy groups. Sonographic parameters for prediction of miscarriage were evaluated by multivariate analysis, and the screening performance was assessed by a receiver operating characteristic curve. Among the 188 pregnancies, 30 (16.0%) had miscarriage. Multivariate analysis showed that fetal heart rate below the 5th percentile (odds ratio, 6.43), gestational sac diameter below the 5th percentile (odds ratio, 4.87), gestational sac volume below the 5th percentile (odds ratio, 5.25), and yolk sac diameter below the 2.5th or above the 97.5th percentile (odds ratio, 15.86) were significant predictors of miscarriage (P = .018; P = .018; P = .033; and P < .001, respectively). At a false-positive rate of 30%, the detection rate for miscarriage in screening by a combination of fetal heart rate, gestational sac diameter, gestational sac volume, and yolk sac diameter was 77.8%. A small-for-gestational-age gestational sac volume is a significant sonographic predictor of miscarriage, as are fetal bradycardia, a small gestational sac diameter, and a small or large yolk sac diameter. © 2015 by the American Institute of Ultrasound in Medicine.

  16. The relationships between tracheal index and lung volume parameters in mild-to-moderate COPD

    Energy Technology Data Exchange (ETDEWEB)

    Eom, Jung Seop, E-mail: ejs00@hanmail.net [Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710 (Korea, Republic of); Lee, Geewon, E-mail: rabkingdom@naver.com [Department of Radiology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 602-739 (Korea, Republic of); Lee, Ho Yun, E-mail: hoyunlee96@gmail.com [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710 (Korea, Republic of); Oh, Jin Young, E-mail: indr71@hanmail.net [Division of Pulmonology, Department of Internal Medicine, Dongguk University Ilsan Medical Center, 814 Siksa-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-773 (Korea, Republic of); Woo, Sook-young, E-mail: sookyoung12.woo@samsung.com [Biostatistics Team, Samsung Biomedical Research Institute, 81 Irwon-ro, Gangnam-gu, Seoul 135-710 (Korea, Republic of); Jeon, Kyeongman, E-mail: kjeon@skku.edu [Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710 (Korea, Republic of); Um, Sang-Won, E-mail: sangwonum@skku.edu [Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710 (Korea, Republic of); Koh, Won-Jung, E-mail: wjkoh@skku.edu [Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710 (Korea, Republic of); Suh, Gee Young, E-mail: suhgy@skku.edu [Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710 (Korea, Republic of); and others

    2013-12-01

    Background: Although elongated morphological changes in the trachea are known to be related to lung function in chronic obstructive pulmonary disease (COPD), whether the tracheal morphological changes are associated with airflow limitations or overinflation of the lung in the early stages of COPD has not yet been determined. Thus, our aim was to investigate the association of tracheal index (TI) with lung function parameters, including lung volume parameters, in COPD patients with mild-to-moderate airflow limitations. Materials and methods: A retrospective study was conducted in 193 COPD patients with GOLD grades 1–2 (post-bronchodilator forced expiratory volume in 1 s [FEV{sub 1}] ≥ 50% predicted with FEV{sub 1}/forced vital capacity ratio ≤ 70%; age range, 40–81) and 193 age- and gender-matched subjects with normal lung function as a control group (age range, 40–82). Two independent observers measured TI at three anatomical levels on chest radiographs and CT scans. Results: Compared with the control group, TI was reduced significantly and “saber-sheath trachea” was observed more frequently in COPD patients. Patients with GOLD grade 2 disease had a lower TI than those with GOLD grade 1. TI had apparent inverse correlations with total lung capacity, functional residual capacity, and residual volume, regardless of the anatomical level of the trachea. Even after adjustments for covariates, this association persisted. Conclusions: TI is reduced even in mild-to-moderate COPD patients, and TI measured on chest CT shows significant inverse relationships with all lung volume parameters assessed, suggesting that tracheal morphology may change during the early stages of COPD.

  17. Slowing polar molecules using a wire Stark decelerator

    CERN Document Server

    Marian, Adela; Geng, Peter; Meijer, Gerard

    2010-01-01

    We have designed and implemented a new Stark decelerator based on wire electrodes, which is suitable for ultrahigh vacuum applications. The 100 deceleration stages are fashioned out of 0.6 mm diameter tantalum and the array's total length is 110 mm, approximately 10 times smaller than a conventional Stark decelerator with the same number of electrode pairs. Using the wire decelerator, we have removed more than 90% of the kinetic energy from metastable CO molecules in a beam.

  18. Parameter Analysis of the VPIN (Volume synchronized Probability of Informed Trading) Metric

    Energy Technology Data Exchange (ETDEWEB)

    Song, Jung Heon; Wu, Kesheng; Simon, Horst D.

    2014-03-01

    VPIN (Volume synchronized Probability of Informed trading) is a leading indicator of liquidity-induced volatility. It is best known for having produced a signal more than hours before the Flash Crash of 2010. On that day, the market saw the biggest one-day point decline in the Dow Jones Industrial Average, which culminated to the market value of $1 trillion disappearing, but only to recover those losses twenty minutes later (Lauricella 2010). The computation of VPIN requires the user to set up a handful of free parameters. The values of these parameters significantly affect the effectiveness of VPIN as measured by the false positive rate (FPR). An earlier publication reported that a brute-force search of simple parameter combinations yielded a number of parameter combinations with FPR of 7%. This work is a systematic attempt to find an optimal parameter set using an optimization package, NOMAD (Nonlinear Optimization by Mesh Adaptive Direct Search) by Audet, le digabel, and tribes (2009) and le digabel (2011). We have implemented a number of techniques to reduce the computation time with NOMAD. Tests show that we can reduce the FPR to only 2%. To better understand the parameter choices, we have conducted a series of sensitivity analysis via uncertainty quantification on the parameter spaces using UQTK (Uncertainty Quantification Toolkit). Results have shown dominance of 2 parameters in the computation of FPR. Using the outputs from NOMAD optimization and sensitivity analysis, We recommend A range of values for each of the free parameters that perform well on a large set of futures trading records.

  19. [Parameters with possible influence in PSA adjusted for transition zone volume].

    Science.gov (United States)

    Jara Rascón, J; Subirá Ríos, D; Lledó Garcia, E; Martínez Salamanca, J I; Moncada Iribarren, I; Cabello Benavente, R; Hernández Fernández, C

    2005-05-01

    To evaluate the effect of age, digital rectal examination results and prostatic volume on PSA value adjusted to transition zone (PSA-TZ) in the detection of prostatic cancer. Data of 243 patients with serum PSA of 4 to 20 ng/ml who underwent biopsy because of prostatic cancer suspicion are analyzed. In this population, cancer was detected in 62 cases (24.8%). Total prostatic volume and transition zone volume were calculated by transrectal echography applying the ellipsoid formula. Applying lineal regresion analysis, it was found no correlation between age and PSA-TZ (Pearson coefficient 0.00). By dividing these patients among those with normal rectal examination (84%) and those with suspicious digital rectal examination (16%), cutoff values of PSA-TZ were found to be not different by ROC curves analysis for 95% sensitivity varying specificity only among 24 and 26% between these two groups of patients. Prostatic size (40 cc) showed that, for obtaining the same 95% sensitivity in the detection of cancer, PSA-TZ value would require to be modified, being 0.17 in large prostates (> 40 cc) and 0.25 in small prostates (< or =40 cc). The utility of PSA-TZ as a potential predictor parameter of prostatic cancer did not need to be modified with respect to age or to data of digital rectal examination. However, for supporting sensivity of its best cutoff value, PSA-TZ would need to be modified with respect to total prostatic volume.

  20. Dumping the decelerated beams of CLIC

    CERN Document Server

    Jeanneret, Bernard

    2011-01-01

    The spent drive beam must be cleanly extracted and bent away from the decelerator axis at the end of each CLIC decelerator in order to leave space for injecting a fresh beam train in the next sector. Then the spent beam must be safely absorbed. A compact extraction system made of a single dipole is proposed. The spent beam is driven to a water dump located at 20m downstream of the extraction point and transversely 6m away of the axis of the main linac. An adequate spread of the beam impact map on the dump offers small temperature excursions in both the dump and its entrance window, allowing for reliable operation and a long lifetime of the system.

  1. Priority probability deceleration deadline-aware TCP

    Institute of Scientific and Technical Information of China (English)

    Jin Ye; Jing Lin; Jiawei Huang

    2015-01-01

    In modern data centers, because of the deadline-agnostic congestion control in transmission control protocol (TCP), many deadline-sensitive flows can not finish before their deadlines. Therefore, providing a higher deadline meeting ratio becomes a critical chal enge in the typical online data intensive (OLDI) ap-plications of data center networks (DCNs). However, a problem named as priority synchronization is found in this paper, which de-creases the deadline meeting ratio badly. To solve this problem, we propose a priority probability deceleration (P2D) deadline-aware TCP. By using the novel probabilistic deceleration, P2D prevents the priority synchronization problem. Simulation results show that P2 D increases the deadline meeting ratio by 20%compared with D2TCP.

  2. Do actuaries believe in longevity deceleration?

    OpenAIRE

    Debonneuil, Edouard; Planchet, Frédéric; Loisel, Stéphane

    2015-01-01

    As more and more people believe that significant life extensions may come soon, should commonly used future mortality assumptions be considered prudent? We find here that commonly used actuarial tables for annuitants – as well as the Lee-Carter model – do not extrapolate life expectancy at the same rate for future years as for past years; instead they produce some longevity deceleration. This is typically because their mortality improvements decrease after a certain age, and those age-specifi...

  3. Universal deceleration of highly polar molecules

    Science.gov (United States)

    Hamamda, Mehdi; Pillet, Pierre; Lignier, Hans; Comparat, Daniel

    2015-04-01

    We propose a method to produce, in a pulsed or continuous way, cold samples of highly polar molecules. Using a pulsed or continuous standard (supersonic) beam of these molecules, our idea consists of transforming the molecules into their anionic counterparts, which are decelerated to a standstill by a well-controlled external electric field and ultimately neutralized. The neutral-to-anion transformation occurs through collisions with Rydberg atoms coming from an additional atomic beam. This Rydberg electron transfer process is possible provided that the molecular species has a sufficiently strong electric dipole (\\gt 2.5 D, i.e., \\gt 8.3× {{10}-30} cm). Whatever the mass of the species, the deceleration stage is realized by a temporally and spatially controlled electric field within a range of less than one centimeter, which is much shorter than in current deceleration experiments of neutral molecules. Once stopped, the molecular anions are neutralized by laser photodetachment or a pulsed electric field process. The resulting molecules might be held and accumulated, for instance, in a magnetic trap.

  4. Decelerating and Trapping Large Polar Molecules.

    Science.gov (United States)

    Patterson, David

    2016-11-18

    Manipulating the motion of large polyatomic molecules, such as benzonitrile (C6 H5 CN), presents significant difficulties compared to the manipulation of diatomic molecules. Although recent impressive results have demonstrated manipulation, trapping, and cooling of molecules as large as CH3 F, no general technique for trapping such molecules has been demonstrated, and cold neutral molecules larger than 5 atoms have not been trapped (M. Zeppenfeld, B. G. U. Englert, R. Glöckner, A. Prehn, M. Mielenz, C. Sommer, L. D. van Buuren, M. Motsch, G. Rempe, Nature 2012, 491, 570-573). In particular, extending Stark deceleration and electrostatic trapping to such species remains challenging. Here, we propose to combine a novel "asymmetric doublet state" Stark decelerator with recently demonstrated slow, cold, buffer-gas-cooled beams of closed-shell volatile molecules to realize a general system for decelerating and trapping samples of a broad range of volatile neutral polar prolate asymmetric top molecules. The technique is applicable to most stable volatile molecules in the 100-500 AMU range, and would be capable of producing trapped samples in a single rotational state and at a motional temperature of hundreds of mK. Such samples would immediately allow for spectroscopy of unprecedented resolution, and extensions would allow for further cooling and direct observation of slow intramolecular processes such as vibrational relaxation and Hertz-level tunneling dynamics.

  5. Brief report: Volume dependence of Grüneisen parameter for solids under extreme compression

    Indian Academy of Sciences (India)

    SANJAY KUMAR; S K SHARMA; O P PANDEY

    2016-08-01

    The Nie expression is amended in such a way that the expression follows the infinite pressure behaviour, i.e., P → ∞or V → 0. A new empirical relationship is developed to predict the values of volume dependence of Grüneisen parameter. NaCl and ε-Fe have been employed to test the suitability of the expression.The results obtained reveal that the relationship is reliable as there is a good agreement between the calculated and the experimental data

  6. Regulating the infrared by mode matching: a massless scalar in expanding spaces with constant deceleration

    NARCIS (Netherlands)

    Janssen, T.M.; Prokopec, T.

    2011-01-01

    In this paper we consider a massless scalar field, with a possible coupling ξ to the Ricci scalar in a D dimensional Friedmann-Lemaître-Robertson-Walker space-time with a constant deceleration parameter q=ϵ-1, ϵ=-H˙/H2. Correlation functions for the Bunch-Davies vacuum of such a theory have long

  7. Preliminary Structural Sensitivity Study of Hypersonic Inflatable Aerodynamic Decelerator Using Probabilistic Methods

    Science.gov (United States)

    Lyle, Karen H.

    2014-01-01

    Acceptance of new spacecraft structural architectures and concepts requires validated design methods to minimize the expense involved with technology validation via flighttesting. This paper explores the implementation of probabilistic methods in the sensitivity analysis of the structural response of a Hypersonic Inflatable Aerodynamic Decelerator (HIAD). HIAD architectures are attractive for spacecraft deceleration because they are lightweight, store compactly, and utilize the atmosphere to decelerate a spacecraft during re-entry. However, designers are hesitant to include these inflatable approaches for large payloads or spacecraft because of the lack of flight validation. In the example presented here, the structural parameters of an existing HIAD model have been varied to illustrate the design approach utilizing uncertainty-based methods. Surrogate models have been used to reduce computational expense several orders of magnitude. The suitability of the design is based on assessing variation in the resulting cone angle. The acceptable cone angle variation would rely on the aerodynamic requirements.

  8. THE INFLUENCE OF THE MAIN PARAMETERS OF TRAIN TRAFFIC VOLUME ON TOTAL PROFITS OF RAILWAYS

    Directory of Open Access Journals (Sweden)

    H. YA. Mozolevich

    2015-04-01

    Full Text Available Purpose. The paper is aimed to influence analysis of parameters such as the number of trains on the section and the length of freight trains, the total profit of the railway and determination of total profit of Prydniprovsk railway for major parts of the trains handling; the determination of the specific rate of return on 1 kilometer operational length of each individual link in the rail network. Methodology. To achieve this goal the simulation models of the sections of railway polygon and the simulation of cargo trains have been developed. On the basis of obtained results the dependence of the main parameters of train traffic and their impact on the overall profit of the railway was determined. Findings. On the basis of the conducted studies the functions operating costs for each section were developed to determine the optimal routes crossing of trains and choice of rational parameters. The operating costs, revenue, total profit of railways and certain impact parameters of train traffic volume on the economic performance of railway transport were calculated with their help. It is determined that freight trains, length 53-56 of a conventional car is optimal to pass and loading area should be 75-85% of the available crossing capacity. Taking into account given results, the electrification of the sections with diesel traction (due to the significant cost of diesel fuel is the priority development of railway transport at the possible increase in size of the movement. Originality. Authors have improved the technology of determining the total profits of railways on the basis of variables train traffic volumes. For the first time the specific rate of profit on the 1 kilometer operational length of the section depending on the size of the average daily traffic is identified and proposed to use to determine the investment attractiveness of the railways. The simulation models of individual sections of the real train polygon at Prydniprovsk railway were

  9. Magnetized anisotropic dark energy models with constant deceleration parameter

    Indian Academy of Sciences (India)

    A Y SHAIKH; S D KATORE

    2016-12-01

    In this paper, we have studied the solutions of plane-symmetric Universe with variable $\\omega$ in the presence and the absence of magnetic field of energy density $\\rho B$. A special law of variation for Hubble’s parameterproposed by Bermann in {\\it Nuovo Cimento} B 74, 182 (1983) has been utilized to solve the field equations. Some physical and kinematical properties of the models are also discussed.

  10. Stopping power: Effect of the projectile deceleration

    Energy Technology Data Exchange (ETDEWEB)

    Kompaneets, Roman, E-mail: kompaneets@mpe.mpg.de; Ivlev, Alexei V.; Morfill, Gregor E. [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstr. 1, 85748 Garching (Germany)

    2014-11-15

    The stopping force is the force exerted on the projectile by its wake. Since the wake does not instantly adjust to the projectile velocity, the stopping force should be affected by the projectile deceleration caused by the stopping force itself. We address this effect by deriving the corresponding correction to the stopping force in the cold plasma approximation. By using the derived expression, we estimate that if the projectile is an ion passing through an electron-proton plasma, the correction is small when the stopping force is due to the plasma electrons, but can be significant when the stopping force is due to the protons.

  11. Decelerating cosmologies are de-scramblers

    CERN Document Server

    Carney, Daniel

    2013-01-01

    Stationary observers in static spacetimes see falling objects spread exponentially fast, or fast-scramble, near event horizons. We generalize this picture to arbitrary cosmological horizons. We give examples of exponential fast-scrambling and power-law scrambling and "de-scrambling" as charges propagate freely near a horizon. In particular we show that when the universe is decelerating, information hidden behind the apparent horizon is de-scrambled as it re-enters the view of the observer. In contrast to the de Sitter case, the power-law scaling suggests that the microscopic dynamics of the horizon are local.

  12. Improved dose-volume histogram estimates for radiopharmaceutical therapy by optimizing quantitative SPECT reconstruction parameters

    Science.gov (United States)

    Cheng, Lishui; Hobbs, Robert F.; Segars, Paul W.; Sgouros, George; Frey, Eric C.

    2013-06-01

    smoothing at early time points post-radiopharmaceutical administration but more smoothing and fewer iterations at later time points when the total organ activity was lower. The results of this study demonstrate the importance of using optimal reconstruction and regularization parameters. Optimal results were obtained with different parameters at each time point, but using a single set of parameters for all time points produced near-optimal dose-volume histograms.

  13. The fermion propagator in cosmological spaces with constant deceleration

    Energy Technology Data Exchange (ETDEWEB)

    Koksma, Jurjen F; Prokopec, Tomislav, E-mail: J.F.Koksma@uu.n, E-mail: T.Prokopec@uu.n [Institute for Theoretical Physics (ITP) and Spinoza Institute, Utrecht University, Postbus 80195, 3508 TD Utrecht (Netherlands)

    2009-06-21

    We calculate the fermion propagator in Friedmann-LemaItre-Robertson-Walker (FLRW) spacetimes with constant deceleration q=epsilon-1, epsilon=-H-dot/H{sup 2} for excited states. For fermions whose mass is generated by a scalar field through a Yukawa coupling m = g{sub Y}phi, we assume phi approx H. We first solve the mode functions by splitting the spinor into a direct product of helicity and chirality spinors. We also allow for non-vacuum states. We normalize the spinors using a consistent canonical quantization and by requiring orthogonality of particle and anti-particle spinors. We apply our propagator to calculate the one-loop effective action and renormalize using dimensional regularization. Since the Hubble parameter is now treated dynamically, this paves the way to study the dynamical backreaction of fermions on the background spacetime.

  14. Delivery Ring Lattice Modifications for Transitionless Deceleration

    Energy Technology Data Exchange (ETDEWEB)

    Johnstone, J. A. [Fermilab; Syphers, M. J. [Northern Illinois U.

    2016-10-09

    A portion of the remnant Tevatron program infrastruc- ture at Fermilab is being reconfigured to be used for the generation and delivery of proton and muon beams for new high-precision particle physics experiments. With the 8 GeV Booster as its primary source, the Mu2e exper- iment will receive 8.9 GeV/c bunched beam on target, after being stored and slow spilled from the Delivery Ring (DR) -- a refurbished debuncher ring from Tevatron anti- proton production. For the Muon g-2 experiment, the DR will be tuned for 3.1 GeV/c to capture muons off of a target before sending them to this experiment's Storage Ring. The apertures in the beam transport systems are optimized for the large muon beams of this lower-energy experiment. In order to provide further flexibility in the operation of the DR for future possible low-energy, high- intensity particle physics experiments (REDTOP[1], for example) and detector development, investigations are underway into the feasibility of decelerating beams from its maximum kinetic energy of 8 GeV level to lower en- ergies, down to 1-2 GeV. In this paper we look at possi- ble lattice modifications to the DR to avoid a transition crossing during the deceleration process. Hardware re- quirements and other operational implications of this scheme will also be discussed.

  15. Parameter Identification for a New Circuit Model Aimed to Predict Body Water Volume

    Directory of Open Access Journals (Sweden)

    GHEORGHE, A.-G.

    2012-11-01

    Full Text Available Intracellular and extracellular water volumes in the human body have been computed using a sequence of models starting with a linear first order RC circuit (Cole model and finishing with the De Lorenzo model. This last model employs a fractional order impedance whose parameters are identified using the frequency characteristics of the impedance module and phase, the latter being not unique. While the Cole model has a two octaves frequency validity range, the De Lorenzo model can be used for three decades. A new linear RC model, valid for a three decades frequency range, is proposed. This circuit can be viewed as an extension of the Cole model for a larger frequency interval, unlike similar models proposed by the same authors.

  16. Estimation of Regurgitant Volume and Orifice in Aortic Regurgitation Combining CW Doppler and Parameter Estimation in a Windkessel Like Model

    Directory of Open Access Journals (Sweden)

    Bjørn A.J. Angelsen

    1991-01-01

    Full Text Available A method for noninvasive estimation of regurgitant orifice and volume in aortic regurgitation is proposed and tested in anaesthesized open chested pigs. The method can be used with noninvasive measurement of regurgitant jet velocity with continuous wave ultrasound Doppler measurements together with cuff measurements of systolic and diastolic systemic pressure in the arm. These measurements are then used for parameter estimation in a Windkessel-like model which include the regurgitant orifice as a parameter. The aortic volume compliance and the peripheral resistance are also included as parameters and estimated in the same process. For the test of the method, invasive measurements in the open chest pigs are used. Electromagnetic flow measurements in the ascending aorta and pulmonary artery are used for control, and a correlation between regurgitant volume obtained from parameter estimation and electromagnetic flow measurements of 0.95 over a range from 2.1 to 17.8 mL is obtained.

  17. Modified electrochemical parameter estimation of NCR18650BD battery using implicit finite volume method

    Science.gov (United States)

    Ashwin, T. R.; McGordon, A.; Widanage, W. D.; Jennings, P. A.

    2017-02-01

    The Pseudo Two Dimensional (P2D) porous electrode model is less preferred for real time calculations due to the high computational expense and complexity in obtaining the wide range of electro-chemical parameters despite of its superior accuracy. This paper presents a finite volume based method for re-parametrising the P2D model for any cell chemistry with uncertainty in determining precise electrochemical parameters. The re-parametrisation is achieved by solving a quadratic form of the Butler-Volmer equation and modifying the anode open circuit voltage based on experimental values. Thus the only experimental result, needed to re-parametrise the cell, reduces to the measurement of discharge voltage for any C-rate. The proposed method is validated against the 1C discharge data and an actual drive cycle of a NCR18650BD battery with NCA chemistry when driving in an urban environment with frequent accelerations and regenerative braking events. The error limit of the present model is compared with the electro-chemical prediction of LiyCoO2 battery and found to be superior to the accuracy of the model presented in the literature.

  18. Collective Deceleration: Toward a Compact Beam Dump

    Energy Technology Data Exchange (ETDEWEB)

    Wu, H.-C.; /Munich, Max Planck Inst. Quantenopt.; Tajima, T.; Habs, D.; /Munich, Max Planck Inst. Quantenopt. /Munich U.; Chao, A.W.; /SLAC; Meyer-ter-Vehn, J.; /Munich, Max Planck Inst. Quantenopt.

    2011-11-28

    With the increasing development of laser accelerators, the electron energy is already beyond GeV and even higher in near future. Conventional beam dump based on ionization or radiation loss mechanism is cumbersome and costly, also has radiological hazards. We revisit the stopping power of high-energy charged particles in matter and discuss the associated problem of beam dump from the point of view of collective deceleration. The collective stopping length in an ionized gas can be several orders of magnitude shorter than the Bethe-Bloch and multiple electromagnetic cascades stopping length in solid. At the mean time, the tenuous density of the gas makes the radioactivation negligible. Such a compact and non-radioactivating beam dump works well for short and dense bunches, which is typically generated from laser wakefield accelerator.

  19. Photogrammetry of a Hypersonic Inflatable Aerodynamic Decelerator

    Science.gov (United States)

    Kushner, Laura Kathryn; Littell, Justin D.; Cassell, Alan M.

    2013-01-01

    In 2012, two large-scale models of a Hypersonic Inflatable Aerodynamic decelerator were tested in the National Full-Scale Aerodynamic Complex at NASA Ames Research Center. One of the objectives of this test was to measure model deflections under aerodynamic loading that approximated expected flight conditions. The measurements were acquired using stereo photogrammetry. Four pairs of stereo cameras were mounted inside the NFAC test section, each imaging a particular section of the HIAD. The views were then stitched together post-test to create a surface deformation profile. The data from the photogram- metry system will largely be used for comparisons to and refinement of Fluid Structure Interaction models. This paper describes how a commercial photogrammetry system was adapted to make the measurements and presents some preliminary results.

  20. Mean reticulocyte volume: a specific parameter to screen for hereditary spherocytosis.

    Science.gov (United States)

    Xu, Yuchan; Yang, Wang; Liao, Lin; Deng, Zengfu; Qiu, Yuling; Chen, Wenqiang; Lin, Faquan

    2016-02-01

    This study assessed the value of mean reticulocyte volume (MRV) for differential diagnosis of hereditary spherocytosis (HS) so as to develop conventional and new specific screen indexes. Subjects in this study were divided into three groups: 53 cases in HS group, 217 cases in hemolytic anemia control group (109 cases of thalassemia (THAL), 56 cases of glucose-6-phosphate dehydrogenase G6PD deficiency anemia, and 52 cases of autoimmune hemolytic anemia (AIHA)), and 100 cases in healthy control group. We analyzed erythrocyte and reticulocyte parameters including MRV, mean sphered corpuscular volume, mean corpuscular hemoglobin concentration, and immature reticulocyte fraction. Results demonstrated that MRV was significantly lower in the HS group but significantly higher in the AIHA and G6PD deficiency anemia groups than that in the healthy control group (P = 0.000). MRV was not significantly different between the AIHA and G6PD deficiency anemia groups (P = 0.977) and between the healthy control and THAL groups (P = 0.168). The area under the ROC curve of MRV for diagnosis of HS was 0.942, with a standard error of 0.019, 95% confidence interval of 0.905-0.979, and optimal critical diagnosis point of 95.77 fL. When the MRV was ≤95.77 fL, the sensitivity and specificity for diagnosis of HS were 86.80% and 91.20%, respectively. Therefore, MRV is a general and specific new index for screening HS and important for differential diagnosis of different types of hemolytic anemia.

  1. Splenic volume measurements on computed tomography utilizing automatically contouring software and its relationship with age, gender, and anthropometric parameters

    Energy Technology Data Exchange (ETDEWEB)

    Harris, Ardene, E-mail: ardene_b@yahoo.co [Department of Radiology, Hokkaido University Hospital, North 15, West 7, Kita-ku, Sapporo 060-0815 (Japan); Kamishima, Tamotsu, E-mail: ktamotamo2@yahoo.co.j [Department of Radiology, Hokkaido University Hospital, North 15, West 7, Kita-ku, Sapporo 060-0815 (Japan); Hao, Hong Yi, E-mail: haohongyi88@yahoo.co.j [Department of Radiology, Hokkaido University Hospital, North 15, West 7, Kita-ku, Sapporo 060-0815 (Japan); Kato, Fumi [Department of Radiology, Hokkaido University Hospital, North 15, West 7, Kita-ku, Sapporo 060-0815 (Japan); Omatsu, Tokuhiko, E-mail: omatoku@me.co [Department of Radiology, Hokkaido University Hospital, North 15, West 7, Kita-ku, Sapporo 060-0815 (Japan); Onodera, Yuya, E-mail: yuyaonodera@med.hokudai.ac.j [Department of Radiology, Hokkaido University Hospital, North 15, West 7, Kita-ku, Sapporo 060-0815 (Japan); Terae, Satoshi, E-mail: saterae@med.hokudai.ac.j [Department of Radiology, Hokkaido University Hospital, North 15, West 7, Kita-ku, Sapporo 060-0815 (Japan); Shirato, Hiroki, E-mail: shirato@med.hokudai.ac.j [Department of Radiology, Hokkaido University Hospital, North 15, West 7, Kita-ku, Sapporo 060-0815 (Japan)

    2010-07-15

    Objective: The present research was conducted to establish the normal splenic volume in adults using a novel and fast technique. The relationship between splenic volume and age, gender, and anthropometric parameters was also examined. Materials and methods: The splenic volume was measured in 230 consecutive patients who underwent computed tomography (CT) scans for various indications. Patients with conditions that have known effect on the spleen size were not included in this study. A new technique using volumetric software to automatically contour the spleen in each CT slice and quickly calculate splenic volume was employed. Inter- and intra-observer variability were also examined. Results: The average splenic volume of all the subjects was 127.4 {+-} 62.9 cm{sup 3}, ranging from 22 to 417 cm{sup 3}. The splenic volume (S) correlated with age (A) (r = -0.33, p < 0.0001), body weight (W) (r = 0.35, p < 0.0001), body mass index (r = 0.24, p < 0.0001) and body surface area (BSA) (r = 0.31, p < 0.0001). The age-adjusted splenic volume index correlated with gender (p = 0.0089). The formulae S = W[6.47A{sup (-0.31)}] and S = BSA[278A{sup (-0.36)}] were derived and can be used to estimate the splenic volume. Inter- and intra-observer variability were 6.4 {+-} 9.8% and 2.8 {+-} 3.5% respectively. Conclusion: Of the anthropometric parameters, the splenic volume was most closely linked to body weight. The automatically contouring software as well as formulae can be used to obtain the volume of the spleen in regular practice.

  2. Combining Magnetic and Electric Sails for Interstellar Deceleration

    CERN Document Server

    Perakis, Nikolaos

    2016-01-01

    The main benefit of an interstellar mission is to carry out in-situ measurements within a target star system. To allow for extended in-situ measurements, the spacecraft needs to be decelerated. One of the currently most promising technologies for deceleration is the magnetic sail which uses the deflection of interstellar matter via a magnetic field to decelerate the spacecraft. However, while the magnetic sail is very efficient at high velocities, its performance decreases with lower speeds. This leads to deceleration durations of several decades depending on the spacecraft mass. Within the context of Project Dragonfly, initiated by the Initiative of Interstellar Studies (i4is), this paper proposes a novel concept for decelerating a spacecraft on an interstellar mission by combining a magnetic sail with an electric sail. Combining the sails compensates for each technologys shortcomings: A magnetic sail is more effective at higher velocities than the electric sail and vice versa. It is demonstrated that using ...

  3. Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Volume 3, Model parameters: Sandia WIPP Project

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-29

    This volume documents model parameters chosen as of July 1992 that were used by the Performance Assessment Department of Sandia National Laboratories in its 1992 preliminary performance assessment of the Waste Isolation Pilot Plant (WIPP). Ranges and distributions for about 300 modeling parameters in the current secondary data base are presented in tables for the geologic and engineered barriers, global materials (e.g., fluid properties), and agents that act upon the WIPP disposal system such as climate variability and human-intrusion boreholes. The 49 parameters sampled in the 1992 Preliminary Performance Assessment are given special emphasis with tables and graphics that provide insight and sources of data for each parameter.

  4. Suitable image parameters and analytical method for quantitatively measuring cerebral blood flow volume with phase-contrast magnetic resonance imaging.

    Directory of Open Access Journals (Sweden)

    Handa H

    1999-02-01

    Full Text Available The aim of this study was to determine suitable image parameters and an analytical method for phase-contrast magnetic resonance imaging (PC-MRI as a means of measuring cerebral blood flow volume. This was done by constructing an experimental model and applying the results to a clinical application. The experimental model was constructed from the aorta of a bull and circulating isotonic saline. The image parameters of PC-MRI (repetition time, flip angle, matrix, velocity rate encoding, and the use of square pixels were studied with percent flow volume (the ratio of actual flow volume to measured flow volume. The most suitable image parameters for accurate blood flow measurement were as follows: repetition time, 50 msec; flip angle, 20 degrees; and a 512 x 256 matrix without square pixels. Furthermore, velocity rate encoding should be set ranging from the maximum flow velocity in the vessel to five times this value. The correction in measuring blood flow was done with the intensity of the region of interest established in the background. With these parameters for PC-MRI, percent flow volume was greater than 90%. Using the image parameters for PC-MRI and the analytical method described above, we evaluated cerebral blood flow volume in 12 patients with occlusive disease of the major cervical arteries. The results were compared with conventional xenon computed tomography. The values found with both methods showed good correlation. Thus, we concluded that PC-MRI was a noninvasive method for evaluating cerebral blood flow in patients with occlusive disease of the major cervical arteries.

  5. Collective deceleration: Toward a compact beam dump

    Directory of Open Access Journals (Sweden)

    H.-C. Wu

    2010-10-01

    Full Text Available With the increasing development of laser electron accelerators, electron energies beyond a GeV have been reached and higher values are expected in the near future. A conventional beam dump based on ionization or radiation loss mechanisms is cumbersome and costly, not to mention the radiological hazards. We revisit the stopping power theory of high-energy charged particles in matter and discuss the associated problem of beam dumping from the point of view of collective deceleration. The collective stopping length in an ionized gas can be several orders of magnitude shorter than that described by the Bethe-Bloch formulas and associated with multiple electromagnetic cascades in solids. At the same time, the tenuous density of the gas makes the radioactivation negligible. Such a compact beam dump without radioactivation works well for short and dense bunches, as they are typically generated from a laser wakefield accelerator. In addition, the nonuniform transverse wakefield can induce microbunching of the electron bunch by betatron oscillation. The microstructure could serve as a prebunched source for coherent radiation or feeding a free electron laser.

  6. Hypersonic Inflatable Aerodynamic Decelerator Ground Test Development

    Science.gov (United States)

    Del Corso, Jospeh A.; Hughes, Stephen; Cheatwood, Neil; Johnson, Keith; Calomino, Anthony

    2015-01-01

    Hypersonic Inflatable Aerodynamic Decelerator (HIAD) technology readiness levels have been incrementally matured by NASA over the last thirteen years, with most recent support from NASA's Space Technology Mission Directorate (STMD) Game Changing Development Program (GCDP). Recently STMD GCDP has authorized funding and support through fiscal year 2015 (FY15) for continued HIAD ground developments which support a Mars Entry, Descent, and Landing (EDL) study. The Mars study will assess the viability of various EDL architectures to enable a Mars human architecture pathfinder mission planned for mid-2020. At its conclusion in November 2014, NASA's first HIAD ground development effort had demonstrated success with fabricating a 50 W/cm2 modular thermal protection system, a 400 C capable inflatable structure, a 10-meter scale aeroshell manufacturing capability, together with calibrated thermal and structural models. Despite the unquestionable success of the first HIAD ground development effort, it was recognized that additional investment was needed in order to realize the full potential of the HIAD technology capability to enable future flight opportunities. The second HIAD ground development effort will focus on extending performance capability in key technology areas that include thermal protection system, lifting-body structures, inflation systems, flight control, stage transitions, and 15-meter aeroshell scalability. This paper presents an overview of the accomplishments under the baseline HIAD development effort and current plans for a follow-on development effort focused on extending those critical technologies needed to enable a Mars Pathfinder mission.

  7. Fuel Cavity Asymmetry at the Onset of Deceleration in ICF

    Science.gov (United States)

    Shah, Rahul C.; Wysocki, F. J.; Glebov, V.; Hakel, P.; Joshi, T.; Kagan, G.; Mancini, R. C.; Murphy, T. J.; Stoeckl, C.; Yaakobi, B.; Benage, J. F.

    2014-10-01

    In ICF, the impact on symmetry of low mode drive non-uniformity is amplified by high convergence. Measurements have shown low mode areal density variation, however, direct impact of low modes on fuel volume has remained undemonstrated. We suggest our images provide first evidence of symmetry loss at the fuel-shell interface. The experiments use direct-drive spherical implosions (Omega). The inner 100 nm layer of the plastic shell is doped with diagnostic Ti to obtain information about interface position, temperature and density. Measurement is made at onset of deceleration at which time nuclear yield rate (NTD) and time resolved (SSCA) spectrum both are in agreement with 1-D prediction. Spectrally resolved images are obtained using the Multiple Monochromatic Imager, which combines a pinhole array with x-ray dispersive mirror and gated detector. Angle averaging of the limb-brightened image data also shows agreement with the 1D calculation. However, the 2D image shows ~20% brightness variations over modes 2-10. These modulations are discussed in context of predicted variations of interface position.

  8. Naturalistic rapid deceleration data: Drivers aged 75 years and older

    Directory of Open Access Journals (Sweden)

    Anna Chevalier

    2016-12-01

    Full Text Available The data presented in this article are related to the research manuscript “Predictors of older drivers’ involvement in rapid deceleration events”, which investigates potential predictors of older drivers’ involvement in rapid deceleration events including measures of vision, cognitive function and driving confidence (A. Chevalier et al., 2016 [1]. In naturalistic driving studies such as this, when sample size is not large enough to allow crashes to be used to investigate driver safety, rapid deceleration events may be used as a surrogate safety measure. Naturalistic driving data were collected for up to 52 weeks from 182 volunteer drivers aged 75–94 years (median 80 years, 52% male living in the suburban outskirts of Sydney. Driving data were collected using an in-vehicle monitoring device. Accelerometer data were recorded 32 times per second and Global Positioning System (GPS data each second. To measure rapid deceleration behavior, rapid deceleration events (RDEs were defined as having at least one data point at or above the deceleration threshold of 750 milli-g (7.35 m/s2. All events were constrained to a maximum 5 s duration. The dataset provided with this article contains 473 events, with a row per RDE. This article also contains information about data processing, treatment and quality control. The methods and data presented here may assist with planning and analysis of future studies into rapid deceleration behaviour using in-vehicle monitoring.

  9. Evaluation of pump characteristic from measurement of fast deceleration

    Directory of Open Access Journals (Sweden)

    Himr Daniel

    2015-01-01

    Full Text Available Article describes an experiment where a pump connected to the simple hydraulic circuit is decelerated. Since the deceleration is fast enough the operating point of the machine moves from the initial steady position to the breaking zone, turbine zone and back to the new steady position. A dependence of the specific energy and the torque on the flow rate was evaluated from the measurement of the input and output pressure, torque and rotational speed recorded during the deceleration. Obtained characteristic is much wider than curves obtained from regular measurement of steady state.

  10. Physics at CERN’s Antiproton Decelerator

    Science.gov (United States)

    Hori, M.; Walz, J.

    2013-09-01

    The Antiproton Decelerator (AD) facility of CERN began operation in 1999 to serve experiments for studies of CPT invariance by precision laser and microwave spectroscopy of antihydrogen (Hbar ) and antiprotonic helium (pbar He) atoms. The first 12 years of AD operation saw cold Hbar synthesized by overlapping clouds of positrons (e+) and antiprotons (pbar ) confined in magnetic Penning traps. Cold Hbar was also produced in collisions between Rydberg positronium (Ps) atoms and pbar . Ground-state Hbar was later trapped for up to ˜1000 s in a magnetic bottle trap, and microwave transitions excited between its hyperfine levels. In the pbar He atom, deep ultraviolet transitions were measured to a fractional precision of (2.3-5)×10-9 by sub-Doppler two-photon laser spectroscopy. From this the antiproton-to-electron mass ratio was determined as M/me=1836.1526736(23), which agrees with the p value known to a similar precision. Microwave spectroscopy of pbar He yielded a measurement of the pbar magnetic moment with a precision of 0.3%. More recently, the magnetic moment of a single pbar confined in a Penning trap was measured with a higher precision, as μ=-2.792845(12)μ in nuclear magnetons. Other results reviewed here include the first measurements of the energy loss (-dE/dx) of 1-100 keV pbar traversing conductor and insulator targets; the cross sections of low-energy (therapy. New experiments under preparation attempt to measure the gravitational acceleration of Hbar or synthesize H. Several other future experiments will also be briefly described.

  11. Influence of food concentration and container volume on life history parameters of Diaptomus dorsalis Marsh from subtropical Florida

    Energy Technology Data Exchange (ETDEWEB)

    Elmore, J.L.

    1982-01-01

    Two experiments were conducted with a subtropical calanoid, Diaptomus dorsalis Marsh 1907, to determine the influence of food concentration and the volume of medium per copepod (one copepod in each of several containers of different volumes) on post-embryonic development rates, adult body size, clutch size, survivorship and sex ratio. Low concentrations of food (Chlamydomonas reinhardti) decreased development rates, body size, clutch size and survivorship; the sex ratio did not vary significantly from 1:1. Small container volumes had the same effects as low food concentrations, except that naupliar development time was not affected and survivorship showed greater variability. Because the copepod parameters exhibited maximum responses when food was abundant, even in the smallest container volume, it was concluded that container volume did not directly influence these parameters but exerted its effect through food availability. Larger life history stages were affected more than smaller life history stages by low food levels. In part, this was attributed to a laboratory artifact in which depletion of food by larger animals was greater than by smaller animals and, in part, to a real effect of low food concentration. A possible explanation of this real effect came from comparisons of these results to data from D. dorsalis fed phytoplankton from a Florida lake. The comparisons suggested that nauplii may be more efficient feeders on, or utilizers of, small food items such as Chlamydomonas.

  12. Quality of life in patients treated by adjuvant radiotherapy for endometrial and cervical cancers: correlation with dose-volume parameters.

    Science.gov (United States)

    Pisani, C; Deantonio, L; Surico, D; Brambilla, M; Galla, A; Ferrara, E; Masini, L; Gambaro, G; Surico, N; Krengli, M

    2016-09-01

    Modern multidisciplinary cancer treatments aim at obtaining minimal influence on patients' quality of life (QoL). The purpose of this study was to assess QoL and correlate it with dose-volume parameters of organ at risks (OARs) in patients who received adjuvant radiotherapy for endometrial and cervical cancers. We administered the EORTC QLQ-C30 and EN24 or CX24 questionnaires to 124 patients, 100 with endometrial cancer and 24 with cervical cancer treated with postoperative radiotherapy ± chemotherapy in regular follow-up. Bladder function, fecal incontinence or urgency and sexual functioning were investigated and correlated with dose-volume parameters of OAR by multiple linear regression analysis. This correlation was assessed by R (2) value. QoL was very high in the majority of patients (82.3 % of patients). Few patients referred urinary incontinence (3.2 %) or abdominal discomfort of high grade (4.0 %). We found a significant correlation between bladder V40, i.e., absolute percentage of bladder volume that received a dose of 40 Gy, and global health status (p radiotherapy for endometrial and cervical cancers have good QoL with minimal limitations of daily activities. QoL was correlated with dose-volume parameters such as bladder V40, mean dose to vagina, maximum dose to trigone and LSP.

  13. Influence of technical parameters on epicardial fat volume quantification at cardiac CT

    Energy Technology Data Exchange (ETDEWEB)

    Bucher, Andreas M. [Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC (United States); Department of Diagnostic and Interventional Radiology, Clinic of the Goethe University, Frankfurt (Germany); Joseph Schoepf, U., E-mail: schoepf@musc.edu [Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC (United States); Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (United States); Krazinski, Aleksander W.; Silverman, Justin; Spearman, James V. [Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC (United States); De Cecco, Carlo N. [Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC (United States); Department of Radiological Sciences, Oncology and Pathology, University of Rome “Sapienza” – Polo Pontino, Latina (Italy); Meinel, Felix G. [Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC (United States); Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital, Munich (Germany); Vogl, Thomas J. [Department of Diagnostic and Interventional Radiology, Clinic of the Goethe University, Frankfurt (Germany); Geyer, Lucas L. [Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC (United States); Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital, Munich (Germany)

    2015-06-15

    Highlights: • Upper threshold levels and contrast enhancement influence epicardial fat volumetry. • Cardiac cycle does not significantly influence epicardial fat volumetry. • Adjustments of upper threshold can lead to comparable volumetry results. - Abstract: Objectives: To systematically analyze the influence of technical parameters on quantification of epicardial fat volume (EATV) at cardiac CT. Methods: 153 routine cardiac CT data sets were analyzed using three-dimensional pericardial border delineation. Three image series were reconstructed per patient: (a) CTA{sub D}: coronary CT angiography (CTA), diastolic phase; (b) CTA{sub S}: coronary CTA, systolic phase; (c) CaSc{sub D}: non-contrast CT, diastolic phase. EATV was calculated using three different upper thresholds (−15HU, −30HU, −45HU). Repeated measures ANOVA, Spearman's rho, and Bland Altman plots were used. Results: Mean EATV differed between all three image series at a −30HU threshold (CTA{sub D} 87.2 ± 38.5 ml, CTA{sub S} 90.9 ± 37.7 ml, CaSc{sub D} 130.7 ± 49.5 ml, P < 0.001). EATV of diastolic and systolic CTA reconstructions did not differ significantly (P = 0.225). Mean EATV for contrast enhanced CTA at a −15HU threshold (CTA{sub D15} 102.4 ± 43.6 ml, CTA{sub S15} 105.3 ± 42.3 ml) could be approximated most closely by non-contrast CT at −45HU threshold (CaSc{sub D45} 105.3 ± 40.8 ml). The correlation was excellent: CTA{sub S15}–CTA{sub D15}, rho = 0.943; CTA{sub D15}–CaSc{sub D45}, rho = 0.905; CTA{sub S15}–CaSc{sub D45}, rho = 0.924; each P < 0.001). Bias values from Bland Altman Analysis were: CTA{sub S15}–CTA{sub D15}, 4.9%; CTA{sub D15}–CaSc{sub D45}, −4.3%; CTA{sub S15}–CaSc{sub D45}, 0.6%. Conclusions: Measured EATV can differ substantially between contrast enhanced and non-contrast CT studies, which can be reconciled by threshold modification. Heart cycle phase does not significantly influence EATV measurements.

  14. Inflatable Aerocapture Decelerators with Shape Morphing Trajectory Control Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed research is focused on developing an aerocapture decelerator that is substantially lighter than other approaches by using lightweight, fiber-reinforced...

  15. Deceleration Driven Wetting Transition Druing "Gentle" Drop Depostion

    CERN Document Server

    Kwon, Hyuk-Min; Varanasi, Kripa K; Patankar, Neelesh A

    2010-01-01

    We present high speed video of Cassie-Baxter to Wenzel drop transition during gentle deposition of droplets where the modest amount of energy is channeled via rapid deceleration into a high water hammer pressure.

  16. Advanced Metal Rubber Sensors for Hypersonic Decelerator Entry Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NanoSonic proposes to design and develop light-weight, low-modulus, and durable Metal Rubber™ sensors for aeroelastic analysis of Hypersonic Decelerator Entry...

  17. Reasons for the weak correlation between prostate volume and urethral resistance parameters in patients with prostatism

    NARCIS (Netherlands)

    R. Kranse (Ries); R. van Mastrigt (Ron); F.H. Schröder (Fritz); J.L.H.R. Bosch (Ruud)

    1995-01-01

    textabstractIn an attempt to increase our understanding of the clinical syndrome of benign prostatic hyperplasia (BPH) an analysis was made of the association between prostate volume as measured by transrectal ultrasound and several reported urodynamically determined urethral resis

  18. Neutrophil volume, conductivity and scatter parameters with effective modeling of molecular activity statistical program gives better results in neonatal sepsis.

    Science.gov (United States)

    Celik, I H; Demirel, G; Sukhachev, D; Erdeve, O; Dilmen, U

    2013-02-01

    Neonatal sepsis remains an important clinical syndrome despite advances in neonatology. Current hematology analyzers can determine cell volume (V), conductivity for internal composition of cell (C) and light scatter for cytoplasmic granularity and nuclear structure (S), and standard deviations which are effective in the diagnosis of sepsis. Statistical models can be used to strengthen the diagnosis. Effective modeling of molecular activity (EMMA) uses combinatorial algorithm of the selection parameters for regression equation based on modified stepwise procedure. It allows obtaining different regression models with different combinations of parameters. We investigated these parameters in screening of neonatal sepsis. We used LH780 hematological analyzer (Beckman Coulter, Fullerton, CA, USA). We combined these parameters with interleukin-6 (IL-6) and C-reactive protein (CRP) and developed models by EMMA. A total of 304 newborns, 76 proven sepsis, 130 clinical sepsis and 98 controls, were enrolled in the study. Mean neutrophil volume (MNV) and volume distribution width (VDW) were higher in both proven and clinical sepsis groups. We developed three models using MNV, VDW, IL-6, and CRP. These models gave more sensitivity and specificity than the usage of each marker alone. We suggest to use the combination of MNV and VDW with markers such as CRP and IL-6, and use diagnostic models created by EMMA. © 2012 Blackwell Publishing Ltd.

  19. Faranoff-Riley type I jet deceleration at density discontinuities

    OpenAIRE

    Meliani, Z.; Keppens, R.; Giacomazzo, B.

    2008-01-01

    Aims. We propose a model that could explain the sudden jet deceleration in active galactic nuclei, thereby invoking density discontinuities. Motivated particularly by recent indications from HYbrid MOrphology Radio Sources (HYMORS) that Fanaroff-Riley classification is induced in some cases by variations in the density of the external medium. We explore how one-sided jet deceleration and a transition to FR I type can occur in HYMORS, which start as FR II (and remain so on the other side). Met...

  20. Permanent magnet quadrupoles for the CLIC Drive Beam decelerator

    CERN Document Server

    Shepherd, Ben; Collomb, Norbert

    2012-01-01

    STFC in collaboration with CERN has developed a new type of adjustable permanent magnet based quadrupole for the CLIC Drive Beam Decelerator. It uses vertical movement of the permanent magnets to achieve an integrated gradient range of 3.6-14.6T, which will allow it to be used for the first 60% of the decelerator line. Construction of a prototype of this magnet has begun; following this, it will be measured magnetically at CERN and Daresbury Laboratory.

  1. Modal Test of Six-Meter Hypersonic Inflatable Aerodynamic Decelerator

    Science.gov (United States)

    Abraham, Nijo; Buehrle, Ralph; Templeton, Justin; Lindell, Mike; Hancock, Sean M.

    2014-01-01

    A modal test was performed on the six-meter Hypersonic Inflatable Aerodynamic Decelerator (HIAD) test article to gain a firm understanding of the dynamic characteristics of the unloaded structure within the low frequency range. The tests involved various configurations of the HIAD to understand the influence of the tri-torus, the varying pressure within the toroids and the influence of straps. The primary test was conducted utilizing an eletrodynamic shaker and the results were verified using a step relaxation technique. The analysis results show an increase in the structure's stiffness with respect to increasing pressure. The results also show the rise of coupled modes with the tri-torus configurations. During the testing activity, the attached straps exhibited a behavior that is similar to that described as fuzzy structures in the literature. Therefore extensive tests were also performed by utilizing foam to mitigate these effects as well as understand the modal parameters of these fuzzy sub structures. Results are being utilized to update the finite element model of the six-meter HIAD and to gain a better understanding of the modeling of complex inflatable structures.

  2. Dose-volume histogram parameters and local tumor control in magnetic resonance image-guided cervical cancer brachytherapy.

    Science.gov (United States)

    Dimopoulos, Johannes C A; Lang, Stefan; Kirisits, Christian; Fidarova, Elena F; Berger, Daniel; Georg, Petra; Dörr, Wolfgang; Pötter, Richard

    2009-09-01

    To investigate the value of dose-volume histogram (DVH) parameters for predicting local control in magnetic resonance (MR) image-guided brachytherapy (IGBT) for patients with cervical cancer. Our study population consists of 141 patients with cervical cancer (Stages IB-IVA) treated with 45-50 Gy external beam radiotherapy plus four times 7 Gy IGBT with or without cisplatin. Gross tumor volume (GTV), high-risk clinical target volume (HRCTV), and intermediate-risk clinical target volume (IRCTV) were contoured, and DVH parameters (minimum dose delivered to 90% of the volume of interest [D90] and D100) were assessed. Doses were converted to the equivalent dose in 2 Gy (EQD2) by applying the linear quadratic model (alpha/beta = 10 Gy). Groups were defined for patients with or without local recurrence (LR) in the true pelvis for tumor size at diagnosis (GTV at diagnosis [GTVD] of 2-5 cm (Group 1) or greater than 5 cm (Group 2) and for tumor size response at IGBT (HRCTV) of 2-5 cm (Group 2a) or greater than 5 cm (Group 2b). Eighteen LRs were observed. The most important DVH parameters correlated with LR were the D90 and D100 for HRCTV. Mean D90 and D100 values for HRCTV were 86 +/- 16 and 65 +/- 10 Gy, respectively. The D90 for HRCTV greater than 87 Gy resulted in an LR incidence of 4% (3 of 68) compared with 20% (15 of 73) for D90 less than 87 Gy. The effect was most pronounced in the tumor group (Group 2b). We showed an increase in local control in IGBT in patients with cervical cancer with the dose delivered, which can be expressed by the D90 and D100 for HRCTV. Local control rates greater than 95% can be achieved if the D90 (EQD2) for HRCTV is 87 Gy or greater.

  3. Elevation profile influence at key contractual performance parameters for LDS (Leak Detection Systems) based on compensated volume balance

    Energy Technology Data Exchange (ETDEWEB)

    Liebenberg, Lieb [TRANSNET Pipeline, Durban (South Africa); Bueno, David; Passos, Rafaela [KANOPUS Consulting, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    This paper describes and discusses procedures and correlations to estimate performance parameters for Leak Detection Systems based on Compensation Volume Balance, at the portions not usually covered by international standards (like, API RP 1130). These parameters include: minimum acceptable leakage to be detected, under steady state conditions, based on flow measurement uncertainty, observed for both pipeline head and tail; an actual flow rate uncertainty against the one informed by the flow meter manufacturer documentation; the reference flow rate for steady state conditions; and the sensitivity one may expect for the system against a given probability of false alarms (i.e., the ways to correlate reliability, the main performance parameter as per API RP 1130 and sensitivity, the second one). A question usually not considered is: how the elevation profile may affect some of these parameters. That is the second main objective addressed herein, with actual examples employed in a South African multi product pipeline. (author)

  4. Late swallowing dysfunction and dysphagia after radiotherapy for pharynx cancer: frequency, intensity and correlation with dose and volume parameters

    DEFF Research Database (Denmark)

    Jensen, Kenneth; Lambertsen, Karin; Grau, Cai

    2007-01-01

    sphincter resulted in a low risk of aspiration. DISCUSSION: Both subjective and objective swallowing problems were frequent and severe after radiotherapy for pharynx cancer. Swallowing dysfunction was correlated with dose and volume parameters of the upper aerodigestive tract. Udgivelsesdato: 2007-Oct...... function after radiotherapy and examine its correlation with irradiated volume and dose. PATIENTS AND METHODS: All recurrence free patients treated for pharynx cancer with radical radiotherapy at our institution, between 1998 and 2002, were invited to participate, 35 (55% of eligible) agreed. Patients were...... in 88%, penetration in 59% and aspiration in 18% of patients. Several significant correlations were found between both subjective and objective swallowing problems and DVH parameters of the upper aerodigestive tract. Doses less than 60 Gy to the supraglottic region, the larynx and upper esophageal...

  5. Novel parameter for assessment of left atrial size in patients with hypertension: ratio of left atrial volume to left ventricular volume

    Institute of Scientific and Technical Information of China (English)

    LI Yue; CHAI Liang; ZHANG Yun; LI Lei

    2009-01-01

    Background Left atrial enlargement has been suggested as a more robust marker of diastolic dysfunction. We hypothesize that the ratio of left atrial volume to left ventricular volume (LAV/LVV) may be more reasonable to reflect left atrial enlargement in the patients with hypertension, because hypertensive patients have a characteristic of concentric remodeling of the left ventricle which is often accompanied with diastolic dysfunction. The aim of this study was to determine if the LAV/LVV can be used as a new parameter to assess left atrial size in hypertensive patients and the relationship between the LAV/LVV and diastolic dysfunction.Methods Ninety-one patients with hypertension and forty-three normal controls were studied. The hypertensive patients were assigned to the normal wall (NW) and hypertrophic wall (HW) groups. The left atrial diameter (LAD), LAV, left atrial volume index (LAVi), LVV and LAV/LVV were measured and calculated by 2-dimensional echocardiography and real time 3-dimensional echocardiography. All of the above parameters were used to evaluate the size of the left atrium. The ratio of peak E velocity of mitral valve inflow to peak E' velocity of lateral mitral annulus (E/E') was measured by pulse Doppler and tissue Doppler. This parameter was used to evaluate diastolic function. Results The LAD, LAV, LAVi, LAV/LVV and E/E' in hypertensive groups were significantly higher than those in the normal group (P <0.05 or 0.01), and those in the HW group were significantly higher than those in the NW group (P <0.05 or 0.01). The E/E' had a positive correlation with LAV, LAVi and LAV/LVV. The correlation coefficient between E/E' and LAV/LVV was relatively higher than that between E/E' and LAD or LAVi.Conclusion LAV/LVV may be used as a new index to evaluate left atrial size in hypertensive patients with diastolic dysfunction.

  6. Internal Mammary Lymph Node Irradiation after Breast Conservation Surgery: Radiation Pneumonitis versus Dose-Volume Histogram Parameters

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joo Young; Lee, Ik Jae; Keum, Ki Chang; Kim, Yong Bae; Shim, Su Jung; Jeong, Kyoung Keun; Kim, Jong Dae; Suh, Chang Ok [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2007-12-15

    Purpose: To evaluate the association between radiation pneumonitis and dose-volume histogram parameters and to provide practical guidelines to prevent radiation pneumonitis following radiotherapy administered for breast cancer including internal mammary lymph nodes. Materials and Methods: Twenty patients with early breast cancer who underwent a partial mastectomy were involved in this study. The entire breast, supraclavicular lymph nodes, and internal mammary lymph nodes were irradiated with a dose of 50.4 Gy in 28 fractions. Radiation pneumonitis was assessed by both radiological pulmonary change (RPC) and by evaluation of symptomatic radiation pneumonitis. Dose-volume histogram parameters were compared between patients with grade <2 RPC and those with grade {>=}2 RPC. The parameters were the mean lung dose, V10 (percent lung volume receiving equal to and more than 10 Gy), V20, V30, V40, and normal tissue complication probability (NTCP). Results: Of the 20 patients, 9 (45%) developed grade 2 RPC and 11 (55%) did not develop RPC (grade 0). Only one patient developed grade 1 symptomatic radiation pneumonitis. Univariate analysis showed that among the dose-volume histogram parameters, NTCP was significantly different between the two RPC grade groups (p <0.05). Fisher's exact test indicated that an NTCP value of 45% was appropriate as an RPC threshold level. Conclusion: This study shows that NTCP can be used as a predictor of RPC after radiotherapy of the internal mammary lymph nodes in breast cancer. Clinically, it indicates that an RPC is likely to develop when the NTCP is greater than 45%.

  7. Effect of intravenous contrast agent volume on colorectal cancer vascular parameters as measured by perfusion computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Goh, V. [Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, London (United Kingdom); Bartram, C. [Intestinal Imaging Centre, St Mark' s Hospital, Harrow, London (United Kingdom); Halligan, S. [Department of Academic Radiology, University College Hospital, London (United Kingdom)], E-mail: s.halligan@ucl.ac.uk

    2009-04-15

    Aim: To determine the effect of two different contrast agent volumes on quantitative and semi-quantitative vascular parameters as measured by perfusion computed tomography (CT) in colorectal cancer. Materials and methods: Following ethical approval and informed consent, eight prospectively recruited patients with proven colorectal adenocarcinoma underwent two separate perfusion CT studies on the same day after (a) 100 ml and (b) 50 ml of a 340 mg/ml iodinated contrast medium, respectively. Quantitative (blood volume, blood flow, permeability surface area product) and semi-quantitative (peak enhancement, time to peak enhancement) tumour vascular parameters were determined using commercial software based on distributed parameter analysis and compared using t-testing. Results: Tumour blood volume, blood flow, and permeability surface area product were not substantially different following the injection of 100 ml and 50 ml contrast medium: 6.12 versus 6.23 ml/100 g tissue; 73.4 versus 71.3 ml/min/100 g tissue; 15.6 versus 15.3 ml/min/100 g tissue for 100 and 50 ml, respectively; p > 0.05. Tumour peak enhancement and time to peak were significantly greater following the injection of 100 ml versus 50 ml contrast medium: 41.2 versus 28.5 HU; 16.1 versus 11.8 s for 100 ml and 50 ml, respectively; p = 0.002; p = 0.0003. Conclusion: Quantitative parameters do not appear to change substantially with a higher contrast agent volume suggesting a combined diagnostic staging-perfusion CT study following a single injection is feasible for colorectal cancer.

  8. Research on Application of Four-parameter Cylinder-volume-ratio Stem Profile%四参数柱干比曲线式应用研究

    Institute of Scientific and Technical Information of China (English)

    孟宪法; 李悦黎; 张方秋

    2001-01-01

    The study involved estimating stem volume, calculating merchantable vo lume yielding rate and timber assortments volume with four-parameter cylinder- vo lume-ratio stem profile. The result shows it performs better than Schumarher-H all at estimating stem volume when the data from Quercus aliena we re classified by cla ss. Compared with taper function at calculating merchantable volume yielding rat e, four-parameter cylinder-volume-ratio stem profile also performs well with sys tematic error below 1% and mean square error below 5%. To Pinus tabu laeformis tr ees, taper function has better accuracy degree than cylinder-volume-rati o method , but the result is contrary to Q.aliena. When calculating t imber assortments vo lume with four-parameter cylinder-volume-ratio method, systematic error is be low 6% and mean square error below 19%.

  9. Relation between injected volume and optical parameters in refilled isolated porcine lenses

    NARCIS (Netherlands)

    Koopmans, SA; Terwee, T; Haitjema, HJ; Deuring, H; van Aarle, S; Kooijman, AC

    2004-01-01

    Purpose: This study was performed to elucidate the correlation between added lens refill material and enhanced lens power as well as the correlation between lens refilling volume and accommodative amplitude as determined by equatorial stretching of ex vivo refilled pigs' lenses. Methods: Nine porcin

  10. Combining Magnetic and Electric Sails for Interstellar Deceleration

    Science.gov (United States)

    Perakis, Nikolaos; Hein, Andreas M.

    2016-07-01

    The main benefit of an interstellar mission is to carry out in-situ measurements within a target star system. To allow for extended in-situ measurements, the spacecraft needs to be decelerated. One of the currently most promising technologies for deceleration is the magnetic sail which uses the deflection of interstellar matter via a magnetic field to decelerate the spacecraft. However, while the magnetic sail is very efficient at high velocities, its performance decreases with lower speeds. This leads to deceleration durations of several decades depending on the spacecraft mass. Within the context of Project Dragonfly, initiated by the Initiative of Interstellar Studies (i4is), this paper proposes a novel concept for decelerating a spacecraft on an interstellar mission by combining a magnetic sail with an electric sail. Combining the sails compensates for each technologys shortcomings: A magnetic sail is more effective at higher velocities than the electric sail and vice versa. It is demonstrated that using both sails sequentially outperforms using only the magnetic or electric sail for various mission scenarios and velocity ranges, at a constant total spacecraft mass. For example, for decelerating from 5% c, to interplanetary velocities, a spacecraft with both sails needs about 29 years, whereas the electric sail alone would take 35 years and the magnetic sail about 40 years with a total spacecraft mass of 8250 kg. Furthermore, it is assessed how the combined deceleration system affects the optimal overall mission architecture for different spacecraft masses and cruising speeds. Future work would investigate how operating both systems in parallel instead of sequentially would affect its performance. Moreover, uncertainties in the density of interstellar matter and sail properties need to be explored.

  11. Acceleration and deceleration capacity of fetal heart rate in an in-vivo sheep model.

    Directory of Open Access Journals (Sweden)

    Massimo W Rivolta

    Full Text Available BACKGROUND: Fetal heart rate (FHR variability is an indirect index of fetal autonomic nervous system (ANS integrity. FHR variability analysis in labor fails to detect early hypoxia and acidemia. Phase-rectified signal averaging (PRSA is a new method of complex biological signals analysis that is more resistant to non-stationarities, signal loss and artifacts. It quantifies the average cardiac acceleration and deceleration (AC/DC capacity. OBJECTIVE: The aims of the study were: (1 to investigate AC/DC in ovine fetuses exposed to acute hypoxic-acidemic insult; (2 to explore the relation between AC/DC and acid-base balance; and (3 to evaluate the influence of FHR decelerations and specific PRSA parameters on AC/DC computation. METHODS: Repetitive umbilical cord occlusions (UCOs were applied in 9 pregnant near-term sheep to obtain three phases of MILD, MODERATE, and SEVERE hypoxic-acidemic insult. Acid-base balance was sampled and fetal ECGs continuously recorded. AC/DC were calculated: (1 for a spectrum of T values (T = 1÷50 beats; the parameter limits the range of oscillations detected by PRSA; (2 on entire series of fetal RR intervals or on "stable" series that excluded FHR decelerations caused by UCOs. RESULTS: AC and DC progressively increased with UCOs phases (MILD vs. MODERATE and MODERATE vs. SEVERE, p<0.05 for DC [Formula: see text] = 2-5, and AC [Formula: see text] = 1-3. The time evolution of AC/DC correlated to acid-base balance (0.4<[Formula: see text]<0.9, p<0.05 with the highest [Formula: see text] for [Formula: see text]. PRSA was not independent from FHR decelerations caused by UCOs. CONCLUSIONS: This is the first in-vivo evaluation of PRSA on FHR analysis. In the presence of acute hypoxic-acidemia we found increasing values of AC/DC suggesting an activation of ANS. This correlation was strongest on time scale dominated by parasympathetic modulations. We identified the best performing [Formula: see text] parameters

  12. Investigation Of The Effects Of Reflow Profile Parameters On Lead-free Solder Bump Volumes And Joint Integrity

    Science.gov (United States)

    Amalu, E. H.; Lui, Y. T.; Ekere, N. N.; Bhatti, R. S.; Takyi, G.

    2011-01-01

    The electronics manufacturing industry was quick to adopt and use the Surface Mount Technology (SMT) assembly technique on realization of its huge potentials in achieving smaller, lighter and low cost product implementations. Increasing global customer demand for miniaturized electronic products is a key driver in the design, development and wide application of high-density area array package format. Electronic components and their associated solder joints have reduced in size as the miniaturization trend in packaging continues to be challenged by printing through very small stencil apertures required for fine pitch flip-chip applications. At very narrow aperture sizes, solder paste rheology becomes crucial for consistent paste withdrawal. The deposition of consistent volume of solder from pad-to-pad is fundamental to minimizing surface mount assembly defects. This study investigates the relationship between volume of solder paste deposit (VSPD) and the volume of solder bump formed (VSBF) after reflow, and the effect of reflow profile parameters on lead-free solder bump formation and the associated solder joint integrity. The study uses a fractional factorial design (FFD) of 24-1 Ramp-Soak-Spike reflow profile, with all main effects and two-way interactions estimable to determine the optimal factorial combination. The results from the study show that the percentage change in the VSPD depends on the combination of the process parameters and reliability issues could become critical as the size of solder joints soldered on the same board assembly vary greatly. Mathematical models describe the relationships among VSPD, VSBF and theoretical volume of solder paste. Some factors have main effects across the volumes and a number of interactions exist among them. These results would be useful for R&D personnel in designing and implementing newer applications with finer-pitch interconnect.

  13. Early Site Permit Demonstration Program: Plant parameters envelope report. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-03-01

    The Early Site Permit (ESP) Demonstration Program is the nuclear industry`s initiative for piloting the early resolution of siting-related issues before the detailed design proceedings of the combined operating license review. The ESP Demonstration Program consists of three phases. The plant parameters envelopes task is part of Phase 1, which addresses the generic review of applicable federal regulations and develops criteria for safety and environmental assessment of potential sites. The plant parameters envelopes identify parameters that characterize the interface between an ALWR design and a potential site, and quantify the interface through values selected from the Utility Requirements Documents, vendor design information, or engineering assessments. When augmented with site-specific information, the plant parameters envelopes provide sufficient information to allow ESPs to be granted based on individual ALWR design information or enveloping design information for the evolutionary, passive, or generic ALWR plants. This document is expected to become a living document when used by future applicants.

  14. Research of Motorcycle Braking Parameters

    Directory of Open Access Journals (Sweden)

    Loreta Levulytė

    2016-12-01

    Full Text Available From a technical point of view, in dangerous or emergency situation is very important motorcycle driver reaction and vehicle braking time. Motor-cycle deceleration parameters depend not only on the motorcycle brake system, but also on the driving experience. A significant influence on decel-eration the motorcycle has aerodynamic parameters, pavement type and condition, as well as the technical condition of the motocycle, shock absorb-ers, tire type and their technical condition. This article provides an analysis of the motorcycle longitudinal deceleration, braking modes of the mo-torcycle on a dry asphalt road surface. Motorcycle stopping – deceleration – acceleration efficiency issue, stopping in different modes. First ana-lyzed the dynamics of a motorcycle deceleration braking only the front wheel, then braked front and rear wheels and complex – then braked the front and rear wheels at the same time. The goal of experimental study is to determine the influence of braking modes intense fir motorcycle brak-ing deceleration when braking on dry road pavement, at three different braking modes, and set the braking path of change. Motorcycle decelera-tion in the longitudinal direction is an important parameter for analysis traffic accidents, for accident reconstruction process and the examination of motorcyclists technical possibility to avoid an accident.

  15. Cosmographic bounds on the cosmological deceleration-acceleration transition redshift in f(R) gravity

    Science.gov (United States)

    Capozziello, Salvatore; Farooq, Omer; Luongo, Orlando; Ratra, Bharat

    2014-08-01

    We examine the observational viability of a class of f(R) gravity cosmological models. Particular attention is devoted to constraints from the recent observational determination of the redshift of the cosmological deceleration-acceleration transition. Making use of the fact that the Ricci scalar is a function of redshift z in these models, R =R(z), and so is f(z), we use cosmography to relate a f(z) test function evaluated at higher z to late-time cosmographic bounds. First, we consider a model-independent procedure to build up a numerical f(z) by requiring that at z=0 the corresponding cosmological model reduces to standard ΛCDM. We then infer late-time observational constraints on f(z) in terms of bounds on the Taylor expansion cosmographic coefficients. In doing so we parametrize possible departures from the standard ΛCDM model in terms of a two-parameter logarithmic correction. The physical meaning of the two parameters is also discussed in terms of the post-Newtonian approximation. Second, we provide numerical estimates of the cosmographic series terms by using type Ia supernova apparent magnitude data and Hubble parameter measurements. Finally, we use these estimates to bound the two parameters of the logarithmic correction. We find that the deceleration parameter in our model changes sign at a redshift consistent with what is observed.

  16. Transmission-line decelerators for atoms in high Rydberg states

    CERN Document Server

    Lancuba, P

    2014-01-01

    Beams of helium atoms in Rydberg states with principal quantum number $n=52$, and traveling with an initial speed of 1950 m/s, have been accelerated, decelerated and guided while confined in moving electric traps generated above a curved, surface-based electrical transmission line with a segmented center conductor. Experiments have been performed with atoms guided at constant speed, and with accelerations exceeding $10^7$ m/s$^2$. In each case the manipulated atoms were detected by spatially resolved, pulsed electric field ionization. The effects of tangential and centripetal accelerations on the effective trapping potentials experienced by the atoms in the decelerator have been studied, with the resulting observations highlighting contributions from the density of excited Rydberg atoms to the acceleration, deceleration and guiding efficiencies in the experiments.

  17. Transmission-line decelerators for atoms in high Rydberg states

    Science.gov (United States)

    Lancuba, P.; Hogan, S. D.

    2014-11-01

    Beams of helium atoms in Rydberg states with principal quantum number n =52 , and traveling with an initial speed of 1950 m/s, have been accelerated, decelerated, and guided while confined in moving electric traps generated above a curved, surface-based electrical transmission line with a segmented center conductor. Experiments have been performed with atoms guided at constant speed, and with accelerations exceeding 107 m /s 2. In each case, the manipulated atoms were detected by spatially resolved, pulsed electric field ionization. The effects of tangential and centripetal accelerations on the effective trapping potentials experienced by the atoms in the decelerator have been studied, with the resulting observations highlighting contributions from the density of excited Rydberg atoms to the acceleration, deceleration, and guiding efficiencies in the experiments.

  18. Rydberg-Stark deceleration of atoms and molecules

    CERN Document Server

    Hogan, Stephen D

    2016-01-01

    The large electric dipole moments associated with highly excited Rydberg states of atoms and molecules make gas-phase samples in these states very well suited to deceleration and trapping using inhomogeneous electric fields. The methods of Rydberg-Stark deceleration with which this can be achieved are reviewed here. Using these techniques, the longitudinal motion of beams of atoms and molecules moving at speeds as high as 2500~m/s have been manipulated, with changes in kinetic energy of up to $|\\Delta E_{\\mathrm{kin}}|=1.3\\times10^{-20}$~J ($|\\Delta E_{\\mathrm{kin}}|/e=80$~meV or $|\\Delta E_{\\mathrm{kin}}|/hc=650$~cm$^{-1}$) achieved, while decelerated and trapped samples with number densities of $10^6$--$10^7$~cm$^{-3}$ and translational temperatures of $\\sim150$~mK have been prepared. Applications of these samples in areas of research at the interface between physics and physical chemistry are discussed.

  19. Effect of potentiating exercise volume on vertical jump parameters in recreationally trained men.

    Science.gov (United States)

    Khamoui, Andy V; Brown, Lee E; Coburn, Jared W; Judelson, Daniel A; Uribe, Brandon P; Nguyen, Diamond; Tran, Tai; Eurich, Alea D; Noffal, Guillermo J

    2009-08-01

    High-force activities have demonstrated postactivation potentiation (PAP) and may enhance performance in athletes; however, the efficacy of high-force activities to generate PAP in recreationally trained men remains unclear. The purpose of this study was to investigate the effect of high-force back squat volume on vertical jump (VJ) height, ground reaction force (GRF), impulse (IMP), and takeoff velocity (TOV) in recreationally trained men. Sixteen recreationally trained men (age 24.56 +/- 2.10 years, height 174.53 +/- 8.54 cm, mass 84.59 +/- 14.75 kg, and 1 repetition maximum [1RM] back squat 124.71 +/- 17.58 kg) with at least 1 year of back squat experience completed 5 testing sessions separated by a minimum of 72 hours' rest. On session 1, subjects completed VJ testing without a potentiating exercise intervention (control condition) in a test-retest fashion (3 VJs, 5 minutes seated rest, and 3 more VJs) and performed 1RM back squat testing. Subjects completed the subsequent 4 testing sessions in a test-retest fashion (3 VJs, experimental condition, 5 minutes seated rest, and 3 more VJs) in random order. The 4 experimental conditions required subjects to perform the back squat using a load of 85% 1RM with volumes of 1 x 2, 1 x 3, 1 x 4, or 1 x 5. Analysis of variance revealed no significant (p > 0.05) condition by time interactions for any dependent variable; however, there were significant (p post 2,094.53 +/- 390.99 N) and IMP (pre 210.88 +/- 100.97 Nxs, > post 204.63 +/- 106.14 Nxs) but not for VJ or TOV. These results suggest that 85% 1RM back squat volume assignments do not produce a VJ potentiation response in recreationally trained men.

  20. Parameters, US Army War College Quarterly. Volume 19, Number 3, September 1989

    Science.gov (United States)

    1989-09-01

    for funds to maintain their combat capability. This period is often depicted as a time of selfish, childish parochialism orchestrated by a group of...on a more vital role in counter- ing this cancerous attack against our national security. Colonel Mike Abbott Annual subscriptions to Parameters are

  1. Preliminary experimental investigation of boundary layer in decelerating flow

    Directory of Open Access Journals (Sweden)

    Příhoda J.

    2013-04-01

    Full Text Available Investigations of characteristics of turbulence inside boundary layer under decelerating flow were studied by means of constant temperature anemometer. The decelerating flow was simulated in the closed circuit wind tunnel 0.9 m × 0.5 m at IT AS CR. The free stream turbulence was either natural o risen up by square mesh plane grid. The details of experimental settings and measurement procedures of the instantaneous longitudinal velocity component are described and the distributions of intensity, skewness and kurtosis of turbulent fluctuations are discussed in the contribution.

  2. Deceleration Effect of Magnetic Field on Black Hole Accretion Disks

    Institute of Scientific and Technical Information of China (English)

    WANG Ding-Xiong

    2000-01-01

    The deceleration effect of magnetic field near the horizon of a spinning black hole (BH) of accretion disk is investigated in the Blandford-Znajek (BZ) process. It is shown that rates of change with respect to time for both the angular velocities of BH horizon and accreting particles at the inner edge of an accretion disk are reduced in the BZ process, behaving with non-monotonous evolution characteristics. This result implies that the magnetic field near the BH horizon has & deceleration effect not only on the spinning BH but also on the surrounding accretion disk.

  3. Desiccator Volume: A Vital Yet Ignored Parameter in CaCO3 Crystallization by the Ammonium Carbonate Diffusion Method

    Directory of Open Access Journals (Sweden)

    Joe Harris

    2017-07-01

    Full Text Available Employing the widely used ammonium carbonate diffusion method, we demonstrate that altering an extrinsic parameter—desiccator size—which is rarely detailed in publications, can alter the route of crystallization. Hexagonally packed assemblies of spherical magnesium-calcium carbonate particles or spherulitic aragonitic particles can be selectively prepared from the same initial reaction solution by simply changing the internal volume of the desiccator, thereby changing the rate of carbonate addition and consequently precursor formation. This demonstrates that it is not merely the quantity of an additive which can control particle morphogenesis and phase selectivity, but control of other often ignored parameters are vital to ensure adequate reproducibility.

  4. Total heart volume as a function of clinical and anthropometric parameters in a population of external beam radiation therapy patients

    Science.gov (United States)

    Nadège Ilembe Badouna, Audrey; Veres, Cristina; Haddy, Nadia; Bidault, François; Lefkopoulos, Dimitri; Chavaudra, Jean; Bridier, André; de Vathaire, Florent; Diallo, Ibrahima

    2012-01-01

    The aim of this paper was to determine anthropometric parameters leading to the least uncertain estimate of heart size when connecting a computational phantom to an external beam radiation therapy (EBRT) patient. From computed tomography images, we segmented the heart and calculated its total volume (THV) in a population of 270 EBRT patients of both sexes, aged 0.7-83 years. Our data were fitted using logistic growth functions. The patient age, height, weight, body mass index and body surface area (BSA) were used as explanatory variables. For both genders, good fits were obtained with both weight (R2 = 0.89 for males and 0.83 for females) and BSA (R2 = 0.90 for males and 0.84 for females). These results demonstrate that, among anthropometric parameters, weight plays an important role in predicting THV. These findings should be taken into account when assigning a computational phantom to a patient.

  5. Cell volume and geometric parameters determination in living cells using confocal microscopy and 3D reconstruction

    OpenAIRE

    sprotocols

    2015-01-01

    Authors: David Hevia, Aida Rodriguez-Garcia, Marta Alonso-Gervós, Isabel Quirós-González, Henar M Cimadevilla, Carmen Gómez-Cordovés, Rosa M Sainz & Juan C Mayo ### Abstract The protocol reported here describes a simple, easy, fast and reproducible method aimed to know the geometric parameters of living cells based on confocal laser scanning microscopy combined with 3D reconstruction software. Briefly, the method is based on intrinsic fluorescence properties of acridine orange (AO...

  6. Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema.

    Science.gov (United States)

    Henriques, Isabela; Padilha, Gisele A; Huhle, Robert; Wierzchon, Caio; Miranda, Paulo J B; Ramos, Isalira P; Rocha, Nazareth; Cruz, Fernanda F; Santos, Raquel S; de Oliveira, Milena V; Souza, Sergio A; Goldenberg, Regina C; Luiz, Ronir R; Pelosi, Paolo; de Abreu, Marcelo G; Silva, Pedro L; Rocco, Patricia R M

    2016-01-01

    Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into two protocols: (1) characterization of an elastase-induced emphysema model in rats and identification of the time point of greatest cardiorespiratory impairment, defined as a high specific lung elastance associated with large right ventricular end-diastolic area; and (2) comparison between variable (VV) and conventional volume-controlled ventilation (VCV) on lung mechanics and morphometry, biological markers, and cardiac function at that time point. In the first protocol, Wistar rats (n = 62) received saline (SAL) or porcine pancreatic elastase (ELA) intratracheally once weekly for 4 weeks, respectively. Evaluations were performed 1, 3, 5, or 8 weeks after the last intratracheal instillation of saline or elastase. After identifying the time point of greatest cardiorespiratory impairment, an additional 32 Wistar rats were randomized into the SAL and ELA groups and then ventilated with VV or VCV (n = 8/group) [tidal volume (VT) = 6 mL/kg, positive end-expiratory pressure (PEEP) = 3 cmH2O, fraction of inspired oxygen (FiO2) = 0.4] for 2 h. VV was applied on a breath-to-breath basis as a sequence of randomly generated VT values (mean VT = 6 mL/kg), with a 30% coefficient of variation. Non-ventilated (NV) SAL and ELA animals were used for molecular biology analysis. The time point of greatest cardiorespiratory impairment, was observed 5 weeks after the last elastase instillation. At this time point, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant (CINC)-1, amphiregulin, angiopoietin (Ang)-2, and vascular endothelial growth factor (VEGF) mRNA levels were higher in ELA compared to SAL. In ELA animals

  7. Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema

    Science.gov (United States)

    Henriques, Isabela; Padilha, Gisele A.; Huhle, Robert; Wierzchon, Caio; Miranda, Paulo J. B.; Ramos, Isalira P.; Rocha, Nazareth; Cruz, Fernanda F.; Santos, Raquel S.; de Oliveira, Milena V.; Souza, Sergio A.; Goldenberg, Regina C.; Luiz, Ronir R.; Pelosi, Paolo; de Abreu, Marcelo G.; Silva, Pedro L.; Rocco, Patricia R. M.

    2016-01-01

    Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into two protocols: (1) characterization of an elastase-induced emphysema model in rats and identification of the time point of greatest cardiorespiratory impairment, defined as a high specific lung elastance associated with large right ventricular end-diastolic area; and (2) comparison between variable (VV) and conventional volume-controlled ventilation (VCV) on lung mechanics and morphometry, biological markers, and cardiac function at that time point. In the first protocol, Wistar rats (n = 62) received saline (SAL) or porcine pancreatic elastase (ELA) intratracheally once weekly for 4 weeks, respectively. Evaluations were performed 1, 3, 5, or 8 weeks after the last intratracheal instillation of saline or elastase. After identifying the time point of greatest cardiorespiratory impairment, an additional 32 Wistar rats were randomized into the SAL and ELA groups and then ventilated with VV or VCV (n = 8/group) [tidal volume (VT) = 6 mL/kg, positive end-expiratory pressure (PEEP) = 3 cmH2O, fraction of inspired oxygen (FiO2) = 0.4] for 2 h. VV was applied on a breath-to-breath basis as a sequence of randomly generated VT values (mean VT = 6 mL/kg), with a 30% coefficient of variation. Non-ventilated (NV) SAL and ELA animals were used for molecular biology analysis. The time point of greatest cardiorespiratory impairment, was observed 5 weeks after the last elastase instillation. At this time point, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant (CINC)-1, amphiregulin, angiopoietin (Ang)-2, and vascular endothelial growth factor (VEGF) mRNA levels were higher in ELA compared to SAL. In ELA animals

  8. Relationship between dose-volume parameters and pulmonary complications after neoadjuvant chemoradiotherapy followed by surgery for lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Shigeo; Shibata, Toru [Kagawa University Hospital, Department of Radiation Oncology, Kagawa (Japan); Go, Tetsuhiko; Kasai, Yoshitaka; Yokomise, Hiroyasu [Kagawa University, Department of General Thoracic, Breast and Endocrine Surgery, Faculty of Medicine, Kagawa (Japan)

    2016-09-15

    This study evaluated the relationship between dose-volume histogram (DVH) parameters and pulmonary complications after neoadjuvant chemoradiotherapy (NACRT) followed by surgery for lung cancer. We also examined a new DVH parameter, because the unresected lung should be more spared than the later resected lung. Data from 43 non-small cell lung cancer patients were retrospectively analyzed. The DVH parameters of the lung were calculated from the total bilateral lung volume minus (1) the gross tumor volume (DVHg) or (2) the later resected lung volume (DVHr). Radiation pneumonitis (RP) and fistula, including bronchopleural and pulmonary fistula, were graded as the pulmonary complications. Factors affecting the incidences of grade 2 or higher RP (≥G2 RP) and fistula were analyzed. Sixteen patients (37 %) experienced ≥G2 RP and a V20 value of the total lung minus the later resected lung (V20r) ≥ 12 % was a significant factor affecting the incidence of ≥G2 RP (p = 0.032). Six patients (14 %) developed a fistula and a V35 value of the total lung minus the gross tumor (V35g) ≥ 19 % and a V40g ≥ 16 % were significant factors affecting the incidence of fistula (p = 0.002 and 0.009, respectively). These DVH parameters may be related to the incidences of ≥G2 RP and fistula. (orig.) [German] In dieser Studie wurde die Beziehung zwischen Dosis-Volumen-Histogramm-(DVH-)Parametern und pulmonalen Komplikationen nach neoadjuvanter Radiochemotherapie (NARCT) und nachfolgender Operation beim Lungenkarzinom untersucht. Zudem wurde ein neuer DVH-Parameter untersucht, da das nichtresezierte Lungengewebe mehr geschont werden sollte als reseziertes Gewebe. Daten von 43 Patienten mit nicht-kleinzelligem Bronchialkarzinom wurden retrospektiv analysiert. Die DVH-Parameter der Lunge wurden aus dem gesamten beidseitigen Lungenvolumen minus (1) das makroskopische Tumorvolumen (DVHg) oder (2) das resezierte Lungenvolumen (DVHr) ermittelt. Strahlenpneumonitis (RP) und Fisteln

  9. Faranoff-Riley type I jet deceleration at density discontinuities

    NARCIS (Netherlands)

    Meliani, Z.; Keppens, R.; Giacomazzo, B.

    2008-01-01

    Aims. We propose a model that could explain the sudden jet deceleration in active galactic nuclei, thereby invoking density discontinuities. Motivated particularly by recent indications from HYbrid MOrphology Radio Sources (HYMORS) that Fanaroff-Riley classification is induced in some cases by varia

  10. Enhancing trappable antiproton populations through deceleration and frictional cooling

    Energy Technology Data Exchange (ETDEWEB)

    Zolotorev, Max; Sessler, Andrew; Penn, Gregory; Wurtele, Jonathan S.; Charman, Andrew E.

    2012-03-20

    CERN currently delivers antiprotons for trapping experiments with the Antiproton Decelerator (AD), which slows the antiprotons down to about 5 MeV.This energy is currently too high for direct trapping, and thick foils are used to slow down the beam to energies which can be trapped.To allow further deceleration to $\\sim 100 \\;\\mbox{keV}$, CERN is initiating the construction of ELENA,consisting of a ring which will combine RF deceleration and electron cooling capabilities. We describe a simple frictionalcooling scheme that can serve to provide significantly improved trapping efficiency, either directly from the AD or first usinga standard deceleration mechanism (induction linac or RFQ). This scheme could be implemented in a short time.The device itself is short in length, uses accessible voltages, and at reasonable cost could serve in the interim beforeELENA becomes operational, or possibly in lieu of ELENA for some experiments. Simple theory and simulations provide a preliminary assessment of theconcept and its strengths and limitations, and highlight important areas for experimental studies, in particular to pin down the level of multiplescattering for low-energy antiprotons. We show that the frictional cooling scheme can provide a similar energy spectrum to that of ELENA,but with higher transverse emittances.

  11. Faranoff-Riley type I jet deceleration at density discontinuities

    NARCIS (Netherlands)

    Meliani, Z.; Keppens, R.; Giacomazzo, B.

    2008-01-01

    Aims. We propose a model that could explain the sudden jet deceleration in active galactic nuclei, thereby invoking density discontinuities. Motivated particularly by recent indications from HYbrid MOrphology Radio Sources (HYMORS) that Fanaroff-Riley classification is induced in some cases by

  12. Enhancing trappable antiproton populations through deceleration and frictional cooling

    Energy Technology Data Exchange (ETDEWEB)

    Zolotorev, M.; Sessler, A.; Penn, G.; Wurtele, J. S.; Charman, A. E.

    2012-03-01

    CERN currently delivers antiprotons for trapping experiments with the Antiproton Decelerator (AD), which slows the antiprotons down to about 5 MeV.This energy is currently too high for direct trapping, and thick foils are used to slow down the beam to energies which can be trapped.To allow further deceleration to $\\sim 100 \\;\\mbox{keV}$, CERN is initiating the construction of ELENA,consisting of a ring which will combine RF deceleration and electron cooling capabilities. We describe a simple frictionalcooling scheme that can serve to provide significantly improved trapping efficiency, either directly from the AD or first usinga standard deceleration mechanism (induction linac or RFQ). This scheme could be implemented in a short time.The device itself is short in length, uses accessible voltages, and at reasonable cost could serve in the interim beforeELENA becomes operational, or possibly in lieu of ELENA for some experiments. Simple theory and simulations provide a preliminary assessment of theconcept and its strengths and limitations, and highlight important areas for experimental studies, in particular to pin down the level of multiplescattering for low-energy antiprotons. We show that the frictional cooling scheme can provide a similar energy spectrum to that of ELENA,but with higher transverse emittances.

  13. IMPROVEMENT OF THE REDLICH-KWONG EQUATION OF STATE BY MODIFICATION OF CO-VOLUME PARAMETER

    Directory of Open Access Journals (Sweden)

    Ratnawati Ratnawati

    2012-02-01

    Full Text Available Cubic equations of state are widely used in phase-equilibrium calculations because of their simplicity and accuracy. Most equations of states are not accurate enough for predicting density of liquid and dense gas. A modification on the Redlich-Kwong (RK equation of state is developed. Parameter b is modified by introducing a new parameter,b, which is a function of molecular weight and temperature. The modification gives a significant improvement over the original RK equation for predicting density. For 6538 data points of 27 compounds, the proposed equation gives only 2.8% of average absolute deviation (AAD, while the original RK and the Soave-Redlich-Kwong (SRK equations give 11.4% and 11.7%, respectively. The proposed modification improves the performance of the RK equation for predicting vapor pressure as well. For 2829 data points of 94 compounds, the proposed modification lowers the AAD of the RK equation from 1460% down to 30.8%. It is comparable to the famous SRK equation, which give 5.8% of AAD. The advantage of the proposed equation is that it uses only critical pressure and temperature as other equations of states do, and molecular weight, which is easily calculated. Another advantage is that the proposed equation simpler than the SRK equation of state.

  14. Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia.

    Science.gov (United States)

    Xu, Lixue; Qin, Wen; Zhuo, Chuanjun; Liu, Huaigui; Zhu, Jiajia; Yu, Chunshui

    2017-03-27

    Diverse brain structural and functional changes have been reported in schizophrenia. Identifying different types of brain changes may help to understand the neural mechanisms and to develop reliable biomarkers in schizophrenia. We aimed to categorize different grey matter changes in schizophrenia based on grey matter volume (GMV) and cerebral blood flow (CBF). Structural and perfusion magnetic resonance imaging data were acquired in 100 schizophrenia patients and 95 healthy comparison subjects. Voxel-based GMV comparison was used to show structural changes, CBF analysis was used to demonstrate functional changes. We identified three types of grey matter changes in schizophrenia: structural and functional impairments in the anterior cingulate cortex and insular cortex, displaying reduction in both GMV and CBF; structural impairment with preserved function in the frontal and temporal cortices, demonstrating decreased GMV with normal CBF; pure functional abnormality in the anterior cingulate cortex and lateral prefrontal cortex and putamen, showing altered CBF with normal GMV. By combination of GMV and CBF, we identified three types of grey matter changes in schizophrenia. These findings may help to understand the complex manifestations and to develop reliable biomarkers in schizophrenia.

  15. Applying dynamic parameters to predict hemodynamic response to volume expansion in spontaneously breathing patients with septic shock.

    Science.gov (United States)

    Lanspa, Michael J; Grissom, Colin K; Hirshberg, Eliotte L; Jones, Jason P; Brown, Samuel M

    2013-02-01

    Volume expansion is a mainstay of therapy in septic shock, although its effect is difficult to predict using conventional measurements. Dynamic parameters, which vary with respiratory changes, appear to predict hemodynamic response to fluid challenge in mechanically ventilated, paralyzed patients. Whether they predict response in patients who are free from mechanical ventilation is unknown. We hypothesized that dynamic parameters would be predictive in patients not receiving mechanical ventilation. This is a prospective, observational, pilot study. Patients with early septic shock and who were not receiving mechanical ventilation received 10-mL/kg volume expansion (VE) at their treating physician's discretion after initial resuscitation in the emergency department. We used transthoracic echocardiography to measure vena cava collapsibility index and aortic velocity variation before VE. We used a pulse contour analysis device to measure stroke volume variation (SVV). Cardiac index was measured immediately before and after VE using transthoracic echocardiography. Hemodynamic response was defined as an increase in cardiac index 15% or greater. Fourteen patients received VE, five of whom demonstrated a hemodynamic response. Vena cava collapsibility index and SVV were predictive (area under the curve = 0.83, 0.92, respectively). Optimal thresholds were calculated: vena cava collapsibility index, 15% or greater (positive predictive value, 62%; negative predictive value, 100%; P = 0.03); SVV, 17% or greater (positive predictive value 100%, negative predictive value 82%, P = 0.03). Aortic velocity variation was not predictive. Vena cava collapsibility index and SVV predict hemodynamic response to fluid challenge patients with septic shock who are not mechanically ventilated. Optimal thresholds differ from those described in mechanically ventilated patients.

  16. Applying dynamic parameters to predict hemodynamic response to volume expansion in spontaneously breathing patients with septic shock

    Science.gov (United States)

    Lanspa, Michael J.; Grissom, Colin K.; Hirshberg, Eliotte L.; Jones, Jason P.; Brown, Samuel M.

    2013-01-01

    Background Volume expansion is a mainstay of therapy in septic shock, although its effect is difficult to predict using conventional measurements. Dynamic parameters, which vary with respiratory changes, appear to predict hemodynamic response to fluid challenge in mechanically ventilated, paralyzed patients. Whether they predict response in patients who are free from mechanical ventilation is unknown. We hypothesized that dynamic parameters would be predictive in patients not receiving mechanical ventilation. Methods This is a prospective, observational, pilot study. Patients with early septic shock and who were not receiving mechanical ventilation received 10 ml/kg volume expansion (VE) at their treating physician's discretion after initial resuscitation in the emergency department. We used transthoracic echocardiography to measure vena cava collapsibility index (VCCI) and aortic velocity variation (AoVV) prior to VE. We used a pulse contour analysis device to measure stroke volume variation (SVV). Cardiac index was measured immediately before and after VE using transthoracic echocardiography. Hemodynamic response was defined as an increase in cardiac index ≥ 15%. Results 14 patients received VE, 5 of which demonstrated a hemodynamic response. VCCI and SVV were predictive (Area under curve = 0.83, 0.92, respectively). Optimal thresholds were calculated: VCCI ≥ 15% (Positive predictive value, PPV 62%, negative predictive value, NPV 100%, p = 0.03); SVV ≥ 17% (PPV 100%, NPV 82%, p = 0.03). AoVV was not predictive. Conclusions VCCI and SVV predict hemodynamic response to fluid challenge patients with septic shock who are not mechanically ventilated. Optimal thresholds differ from those described in mechanically ventilated patients. PMID:23324885

  17. Generation of THz-radiation in the Cherenkov decelerating structure with planar geometry at frequency ∼ 0.675 THz

    Science.gov (United States)

    Ashanin, I. A.; Polozov, S. M.

    2016-07-01

    One of the ways to generate THz-radiation is by the relativistic electron bunches travelling through Cherenkov decelerating dielectric filled capillary channel. Sapphire or other dielectric materials can be used for the internal surface coating of the capillary. Relativistic electron bunches of ∼100 µm in diameter and pulse durations of 1 ps or shorter are capable to produce substantial power of THz-radiation. The aperture of Cherenkov decelerating structure should be comparable with the sub-mm wavelength (0.05-3 mm). Such type of decelerating system allows providing of the wide range of operating parameters at the various geometrical sizes. But it is necessary to consider that such capillaries are difficult in production as there is a requirement to drill a small aperture in a long crystal of high hardness but brittle. In this regard it would be desirable to offer transition option from the axial to the planar geometry. Furthermore the ribbon beam has some advantages as focusing at low energies and possessing smaller expansion in the drift space. The authors present design and results of electrodynamics study of the decelerating planar dielectric filling Cherenkov channel at frequency 0.675 THz in this article. It is also delivered characteristic comparison with axial geometry channel. A horn antenna attached to such channel at 0.675 THz resonant frequency is considered.

  18. Derivation of parameters necessary for the evaluation of performance of sites for deep geological repositories with particular reference to bedded salt, Livermore, California. Volume II. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Ashby, J.P.; Rawlings, G.E.; Soto, C.A.; Wood, D.F.; Chorley, D.W.

    1979-12-01

    The method of selection of parameters to be considered in the selection of a site for underground disposal of radioactive wastes is reported in volume 1. This volume contains the appendix to that report. The topics include: specific rock mechanics tests; drilling investigation techniques and equipment; geophysical surveying; theoretical study of a well text in a nonhomogeneous aquifer; and basic statistical and probability theory that may be used in the derivation of input parameters.

  19. Optimizing the Stark-decelerator beamline for the trapping of cold molecules using evolutionary strategies

    CERN Document Server

    Gilijamse, J J; Hoekstra, S; De van Meerakker, S Y T; Meijer, G; Gilijamse, Joop J.; K\\"upper, Jochen; Hoekstra, Steven; Meerakker, Sebastiaan Y. T. van de; Meijer, Gerard

    2006-01-01

    We demonstrate feedback control optimization for the Stark deceleration and trapping of neutral polar molecules using evolutionary strategies. In a Stark-decelerator beamline pulsed electric fields are used to decelerate OH radicals and subsequently store them in an electrostatic trap. The efficiency of the deceleration and trapping process is determined by the exact timings of the applied electric field pulses. Automated optimization of these timings yields an increase of 40 % of the number of trapped OH radicals.

  20. Two-fluid Atmosphere from Decelerating to Accelerating FRW Dark Energy Models

    CERN Document Server

    Pradhan, Anirudh

    2012-01-01

    The evolution of the dark energy parameter within the scope of a spatially homogeneous and isotropic Friedmann-Robertson-Walker (FRW) model filled with perfect fluid and dark energy components is studied by revisiting the recent results (Amirhashchi et al. in Int. J. Theor. Phys. 50: 3529, 2011). The two sources are claimed to interact minimally so that their energy momentum tensors are conserved separately. To prevail the deterministic solution we consider a time dependent deceleration parameter (DP) i.e. $q = -\\frac{a\\ddot{a}}{\\dot{a}^{2}} = b(a(t))$, which yields a scale factor $a = [\\sinh (\\alpha t)]^{\\frac{1}{n}}$, where $\\alpha$ and $n$ are arbitrary constants. This provides for a model which generates a transition of the universe from the early decelerating phase to the recent accelerating phase. It is observed that the transition red shift ($z_{t}$) for our derived model with $q_{0} = -0.73$ is $\\cong 0.32$. This is in good agreement with the cosmological observations in the literature. The physical a...

  1. Soft SUSY breaking parameters and RG running of squark and slepton masses in large volume Swiss Cheese compactifications

    Science.gov (United States)

    Misra, Aalok; Shukla, Pramod

    2010-03-01

    We consider type IIB large volume compactifications involving orientifolds of the Swiss Cheese Calabi-Yau WCP[1,1,1,6,9] with a single mobile space-time filling D3-brane and stacks of D7-branes wrapping the “big” divisor ΣB (as opposed to the “small” divisor usually done in the literature thus far) as well as supporting D7-brane fluxes. After reviewing our proposal of [1] (Misra and Shukla, 2010) for resolving a long-standing tension between large volume cosmology and phenomenology pertaining to obtaining a 10 GeV gravitino in the inflationary era and a TeV gravitino in the present era, and summarizing our results of [1] (Misra and Shukla, 2010) on soft supersymmetry breaking terms and open-string moduli masses, we discuss the one-loop RG running of the squark and slepton masses in mSUGRA-like models (using the running of the gaugino masses) to the EW scale in the large volume limit. Phenomenological constraints and some of the calculated soft SUSY parameters identify the D7-brane Wilson line moduli as the first two generations/families of squarks and sleptons and the D3-brane (restricted to the big divisor) position moduli as the two Higgses for MSSM-like models at TeV scale. We also discuss how the obtained open-string/matter moduli make it easier to impose FCNC constraints, as well as RG flow of off-diagonal squark mass(-squared) matrix elements.

  2. An electrostatic deceleration lens for highly charged ions.

    Science.gov (United States)

    Rajput, J; Roy, A; Kanjilal, D; Ahuja, R; Safvan, C P

    2010-04-01

    The design and implementation of a purely electrostatic deceleration lens used to obtain beams of highly charged ions at very low energies is presented. The design of the lens is such that it can be used with parallel as well as diverging incoming beams and delivers a well focused low energy beam at the target. In addition, tuning of the final energy of the beam over a wide range (1 eV/q to several hundred eV/q, where q is the beam charge state) is possible without any change in hardware configuration. The deceleration lens was tested with Ar(8+), extracted from an electron cyclotron resonance ion source, having an initial energy of 30 keV/q and final energies as low as 70 eV/q have been achieved.

  3. Optical Stark decelerator for molecules with a traveling potential well

    Science.gov (United States)

    Deng, Lianzhong; Hou, Shunyong; Yin, Jianping

    2017-03-01

    We propose a versatile scheme to slow supersonically cooled molecules using a decelerating potential well, obtained by steering a focusing laser beam onto a pair of spinning reflective mirrors under a high-speed brake. The longitudinal motion of molecules in the moving red-detuned light field is analyzed and their corresponding phase-space stability is investigated. Trajectories of C H4 molecules under the influence of the potential well are simulated using the Monte Carlo method. For instance, with a laser beam of power 20 kW focused onto a spot of waist radius 40-100 μm, corresponding to a peak laser intensity on the order of ˜108W /c m2 , a C H4 molecule of ˜250 m /s can be decelerated to ˜10 m /s over a distance of a few centimeters on a time scale of hundreds of microseconds.

  4. C-arm flat detector computed tomography parenchymal blood volume imaging: the nature of parenchymal blood volume parameter and the feasibility of parenchymal blood volume imaging in aneurysmal subarachnoid haemorrhage patients

    Energy Technology Data Exchange (ETDEWEB)

    Kamran, Mudassar; Byrne, James V. [University of Oxford, Nuffield Department of Surgical Sciences, Oxford (United Kingdom)

    2015-09-15

    C-arm flat detector computed tomography (FDCT) parenchymal blood volume (PBV) measurements allow assessment of cerebral haemodynamics in the neurointerventional suite. This paper explores the feasibility of C-arm computed tomography (CT) PBV imaging and the relationship between the C-arm CT PBV and the MR-PWI-derived cerebral blood volume (CBV) and cerebral blood flow (CBF) parameters in aneurysmal subarachnoid haemorrhage (SAH) patients developing delayed cerebral ischemia (DCI). Twenty-six patients with DCI following aneurysmal SAH underwent a research C-arm CT PBV scan using a biplane angiography system and contemporaneous MR-PWI scan as part of a prospective study. Quantitative whole-brain atlas-based volume-of-interest analysis in conjunction with Pearson correlation and Bland-Altman tests was performed to explore the agreement between C-arm CT PBV and MR-derived CBV and CBF measurements. All patients received medical management, while eight patients (31 %) underwent selective intra-arterial chemical angioplasty. Colour-coded C-arm CT PBV maps were 91 % sensitive and 100 % specific in detecting the perfusion abnormalities. C-arm CT rPBV demonstrated good agreement and strong correlation with both MR-rCBV and MR-rCBF measurements; the agreement and correlation were stronger for MR-rCBF relative to MR-rCBV and improved for C-arm CT PBV versus the geometric mean of MR-rCBV and MR-rCBF. Analysis of weighted means showed that the C-arm CT PBV has a preferential blood flow weighting (∼60 % blood flow and ∼40 % blood volume weighting). C-arm CT PBV imaging is feasible in DCI following aneurysmal SAH. PBV is a composite perfusion parameter incorporating both blood flow and blood volume weightings. That PBV has preferential (∼60 %) blood flow weighting is an important finding, which is of clinical significance when interpreting the C-arm CT PBV maps, particularly in the setting of acute brain ischemia. (orig.)

  5. Feasibility of Seeding Primordial Perturbations in a Decelerated Expanding Universe

    CERN Document Server

    Piao, Y S

    2006-01-01

    The scalar field with the modified dispersion relation under certain conditions may seed the primordial perturbations during a decelerated expansion. In this note we examine whether and how these perturbations can be responsible for the structure formation of observable universe. We find that there seems slightly difficult in matching the requirements of observable cosmology, i.e. obtain simultaneously the scale invariant spectrum of primordial perturbations and enough "efolding number", in a simple case. We discuss possible solutions to this problem.

  6. Hypersonic Inflatable Aerodynamic Decelerator (HIAD) Technology Development Overview

    Science.gov (United States)

    Hughes, Stephen J.; Cheatwood, F. McNeil; Calomino, Anthony M.; Wright, Henry S.; Wusk, Mary E.; Hughes, Monica F.

    2013-01-01

    The successful flight of the Inflatable Reentry Vehicle Experiment (IRVE)-3 has further demonstrated the potential value of Hypersonic Inflatable Aerodynamic Decelerator (HIAD) technology. This technology development effort is funded by NASA's Space Technology Mission Directorate (STMD) Game Changing Development Program (GCDP). This paper provides an overview of a multi-year HIAD technology development effort, detailing the projects completed to date and the additional testing planned for the future.

  7. Tragedy and delight: the ethics of decelerated ageing

    Science.gov (United States)

    Gems, David

    2011-01-01

    Biogerontology is sometimes viewed as similar to other forms of biomedical research in that it seeks to understand and treat a pathological process. Yet the prospect of treating ageing is extraordinary in terms of the profound changes to the human condition that would result. Recent advances in biogerontology allow a clearer view of the ethical issues and dilemmas that confront humanity with respect to treating ageing. For example, they imply that organismal senescence is a disease process with a broad spectrum of pathological consequences in late life (causing or exascerbating cardiovascular disease, cancer, neurodegenerative disease and many others). Moreover, in laboratory animals, it is possible to decelerate ageing, extend healthy adulthood and reduce the age-incidence of a broad spectrum of ageing-related diseases. This is accompanied by an overall extension of lifespan, sometimes of a large magnitude. Discussions of the ethics of treating ageing sometimes involve hand-wringing about detrimental consequences (e.g. to society) of marked life extension which, arguably, would be a form of enhancement technology. Yet given the great improvements in health that decelerated ageing could provide, it would seem that the only possible ethical course is to pursue it energetically. Thus, decelerated ageing has an element of tragic inevitability: its benefits to health compel us to pursue it, despite the transformation of human society, and even human nature, that this could entail. PMID:21115537

  8. Rydberg-Stark deceleration of atoms and molecules

    Energy Technology Data Exchange (ETDEWEB)

    Hogan, Stephen D. [University College London, Department of Physics and Astronomy, London (United Kingdom)

    2016-12-15

    The large electric dipole moments associated with highly excited Rydberg states of atoms and molecules make gas-phase samples in these states very well suited to deceleration and trapping using inhomogeneous electric fields. The methods of Rydberg-Stark deceleration with which this can be achieved are reviewed here. Using these techniques, the longitudinal motion of beams of atoms and molecules moving at speeds as high as 2500 m/s have been manipulated, with changes in kinetic energy of up to vertical stroke ΔE{sub kin} vertical stroke = 1.3 x 10{sup -20} J (vertical stroke ΔE{sub kin} vertical stroke /e = 80 meV or vertical stroke ΔE{sub kin} vertical stroke /hc = 650 cm{sup -1}) achieved, while decelerated and trapped samples with number densities of 10{sup 6}-10{sup 7} cm{sup -3} and translational temperatures of ∝150 mK have been prepared. Applications of these samples in areas of research at the interface between physics and physical chemistry are discussed. (orig.)

  9. Least Squares Best Fit Method for the Three Parameter Weibull Distribution: Analysis of Tensile and Bend Specimens with Volume or Surface Flaw Failure

    Science.gov (United States)

    Gross, Bernard

    1996-01-01

    Material characterization parameters obtained from naturally flawed specimens are necessary for reliability evaluation of non-deterministic advanced ceramic structural components. The least squares best fit method is applied to the three parameter uniaxial Weibull model to obtain the material parameters from experimental tests on volume or surface flawed specimens subjected to pure tension, pure bending, four point or three point loading. Several illustrative example problems are provided.

  10. Modeling experiments on the deceleration and reactivation of Kangerlussuup Sermusa, West Greenland

    Science.gov (United States)

    Rezvanbehbahani, S.; Stearns, L. A.; van der Veen, C. J.; Catania, G. A.

    2015-12-01

    Seasonal variations in outlet glacier velocity due to basal sliding are well-documented and typically involve acceleration early in the melt season due to enhanced sliding as a result of inefficient drainage of surface water reaching the bed. However, velocity observations from Kangerlussuup Sermusa (KS) in West Greenland contradict this pattern. Instead, ice velocity at KS shows no significant change in early spring compared with the previous winter. This sluggish response of the glacier to spring melt is often followed by an extreme, and short-lived, deceleration. For example, in August 2010, the lower 20 km of the trunk decelerated from about 1600 m a-1 to less than 250 m a-1; this event was followed by a rapid reactivation back to the previous velocity in less than 60 days. Available records since 2006 show that the sequence of steady spring velocity, followed by summer deceleration, and rapid fall reactivation occurs annually; however, the magnitudes of deceleration vary. In this regard, the response of KS to regional environmental forcings is unique compared to its neighboring glaciers. In this study, we investigate whether the unique behavior of KS can be explained by the interaction between changes in basal conditions and the local geometry of the glacier. We model the glacier flow by solving full-Stokes equations using the finite element method in the open-source FEniCS framework. Assuming isothermal ice within the lower trunk, we run experiments on the mechanical properties and boundary conditions of the glacier. These experiments include spatio-temporal changes in basal slipperiness, periodic melt-water influx to the bed, and ice viscosity variations due to changes in melt-water supply to the bed. We also conduct sensitivity analyses on the glacier flow with different ice geometries (e.g. thickness and surface slope) to investigate conditions under which we can produce the unique seasonal behavior of KS. Finally, we assess the impact of the combination

  11. Influence of decelerating flow on incipient motion of a gravel-bed stream

    Indian Academy of Sciences (India)

    Hossein Afzalimhr; Subhasish Dey; Pooneh Rasoulianfar

    2007-10-01

    An experimental study on incipient motion of gravel-bed streams under steady-decelerating flow is presented. Experiments were carried out in a flume with two median grain sizes, $d_{50} =$ 16·7 mm for a fixed-bed case and $d_{50} =$ 8 mm for a mobile bed case. In addition, an effort is made to determine a simplified method for the estimation of bed shear stress in decelerating flow over fixed and mobile beds for use in field situations. From the observation of eleven fixed-bed and nine mobile-bed velocity profiles, it is revealed that the parabolic law method (PLM) and the Reynolds stress method are comparable for estimation of shear velocity in general. Also, the results show that the shear stress distribution adopts a convex form over fixed and mobile beds. Due to this form the critical Shields parameter value for decelerating flow is less than the reported values in literature. This paper supports Buffington & Montgomery (1997) statement that less emphasis should be given on choosing a universal shields parameter, and more emphasis should be given on choosing defendable values based on flow structure.

  12. Discriminant analysis of bronchial asthma by linear discriminant function with parameters of flow-volumes: discriminant analysis of bronchial asthma in young male non-smokers

    Directory of Open Access Journals (Sweden)

    Meguro,Tadamichi

    1978-10-01

    Full Text Available With the parameters of a flow-volume and a volume-time curve, the discriminant analysis of bronchial asthma is described. The subjects were classified into three groups (healthy adults, mild asthmatic patients and moderates ones. The difference of the mean vectors of the parameters of the three groups was made clear by the selection methods of the discriminant analysis between any two of the groups both with 6 parameters (%FVC, FEV1.0%, peak flow rate (PF, flow rate at 50% of FVC (V50, flow rate at 25% of FVC (V25, and V50/V25 and with 8 (6 parameters mentioned above and V75, V10. Forced expiratory volume in 1 second percent (FEV1.0% or V50 was selected at the first step with 6 parameters, and V75 was selected at the first step with 8 parameters. Probabilities of misclassification with 8 parameters were lower than those with 6 ones and the probability of misclassification at the discriminant analysis between healthy adults and mild asthmatic patients with 8 parameters was 15.75% at the final step.

  13. Arterial pressure variations as parameters of brain perfusion in response to central blood volume depletion and repletion

    Directory of Open Access Journals (Sweden)

    Anne-Sophie G.T. Bronzwaer

    2014-04-01

    Full Text Available Rationale:A critical reduction in central blood volume (CBV is often characterized by hemodynamic instability. Restoration of a volume deficit may be established by goal-directed fluid therapy guided by respiration-related variation in systolic- and pulse pressure (SPV and PPV. Stroke volume index (SVI serves as a surrogate end-point of a fluid challenge but tissue perfusion itself has not been addressed. Objective: To delineate the relationship between arterial pressure variations, SVI and regional brain perfusion during CBV depletion and repletion in spontaneously breathing volunteers. Methods: This study quantified in 14 healthy subjects (11 male the effects of CBV depletion (by 30 and 70 degrees passive head-up tilt (HUT and a fluid challenge (by tilt back on CBV (thoracic admittance, mean middle cerebral artery (MCA blood flow velocity (Vmean, SVI, cardiac index (CI , PPV and SPV. Results: PPV (103±89%, p< 0.05 and SPV (136±117%, p< 0.05 increased with progression of central hypovolemia manifested by a reduction in thoracic admittance (11±5%, p< 0.001, SVI (28±6%, p< 0.001, CI (6±8%, p< 0.001 and MCAVmean (17±7%, p< 0.05 but not in arterial pressure. The reduction in MCAVmean correlated to the fall in SVI (R2=0.52, p< 0.0001 and inversely to PPV and SPV (R2=0.46 (p< 0.0001 and R2=0.45 (p< 0.0001, respectively. PPV and SPV predicted a ≥15% reduction in MCAVmean and SVI with comparable sensitivity (67%/ 67% vs. 63%/ 68% respectively and specificity (89%/94% vs. 89%/94%, respectively. A rapid fluid challenge by tilt-back restored all parameters to baseline values within one minute. Conclusion: In spontaneously breathing subjects, a reduction in MCAVmean was related to an increase in PPV and SPV during graded CBV depletion and repletion. Specifically, PPV and SPV predicted changes in both SVI and MCAVmean with comparable sensitivity and specificity, however the predictive value is limited in spontaneously breathing subjects.

  14. Effect of Scanning and Reconstruction Parameters on Three Dimensional Volume and CT Value Measurement of Pulmonary Nodules: A Phantom Study

    Directory of Open Access Journals (Sweden)

    Datong SU

    2017-08-01

    Full Text Available Background and objective The computed tomography (CT follow-up of indeterminate pulmonary nodules aiming to evaluate the change of the volume and CT value is the common strategy in clinic. The CT dose needs to considered on serious CT scans in addition to the measurement accuracy. The purpose of this study is to quantify the precision of pulmonary nodule volumetric measurement and CT value measurement with various tube currents and reconstruction algorithms in a phantom study with dual-energy CT. Methods A chest phantom containing 9 artificial spherical solid nodules with known diameter (D=2.5 mm, 5 mm, 10 mm and density (-100 HU, 60 HU and 100 HU was scanned using a 64-row detector CT canner at 120 Kilovolt & various currents (10 mA, 20 mA, 50 mA, 80 mA,100 mA, 150 mA and 350 mA. Raw data were reconstructed with filtered back projection and three levels of adaptive statistical iterative reconstruction algorithm (FBP, ASIR; 30%, 50% and 80%. Automatic volumetric measurements were performed using commercially available software. The relative volume error (RVE and the absolute attenuation error (AAE between the software measures and the reference-standard were calculated. Analyses of the variance were performed to evaluate the effect of reconstruction methods, different scan parameters, nodule size and attenuation on the RPE. Results The software substantially overestimated the very small (D=2.5 mm nodule's volume [mean RVE: (100.8%±28%] and underestimated it attenuation [mean AAE: (-756±80 HU]. The mean RVEs of nodule with diameter as 5 mm and 10 mm were small [(-0.9%±1.1% vs (0.9%±1.4%], however, the mean AAEs [(-243±26 HU vs (-129±7 HU] were large. The ANOVA analysis for repeated measurements showed that different tube current and reconstruction algorithm had no significant effect on the volumetric measurements for nodules with diameter of 5 mm and 10 mm (F=5.60, P=0.10 vs F=11.13, P=0.08, but significant effects on the measurement of CT

  15. Collective Deceleration of Laser-Driven Electron Bunches

    Science.gov (United States)

    Chou, S.; Xu, J.; Khrennikov, K.; Cardenas, D. E.; Wenz, J.; Heigoldt, M.; Hofmann, L.; Veisz, L.; Karsch, S.

    2016-09-01

    Few-fs electron bunches from laser wakefield acceleration (LWFA) can efficiently drive plasma wakefields (PWFs), as shown by their propagation through underdense plasma in two experiments. A strong and density-insensitive deceleration of the bunches has been observed in 2 mm of 1 018 cm-3 density plasma with 5.1 GV /m average gradient, which is attributed to a self-driven PWF. This observation implies that the physics of PWFs, usually relying on large-scale rf accelerators as drivers, can be studied by tabletop LWFA electron sources.

  16. Effects of oral powder electrolyte administration on packed cell volume, plasma chemistry parameters, and incidence of colic in horses participating in a 6-day 162-km trail ride.

    Science.gov (United States)

    Walker, Wade T; Callan, Robert J; Hill, Ashley E; Tisher, Kelly B

    2014-08-01

    This study evaluated the effects of administering oral powder electrolytes on packed cell volume (PCV), plasma chemistry parameters, and incidence of colic in horses participating on a 6-day 162-km trail ride in which water was not offered ad libitum. Twenty-three horses received grain with powder electrolytes daily while 19 control horses received grain only. Horses were ridden approximately 32 km a day at a walk or trot. Packed cell volume and plasma chemistry parameters were analyzed daily. Episodes of colic were diagnosed and treated by a veterinarian unaware of treatment group allocation. Blood parameters and incidence of colic were compared between treatment groups. Electrolyte administration did not alter PCV or plasma chemistry parameters compared to controls. The incidence of colic was significantly higher in treated horses (P = 0.05). Oral powder electrolytes did not enhance hydration status or electrolyte homeostasis and may be associated with colic in horses participating on long distance trail rides similar to this model.

  17. The Fate of Young Radio Galaxies: Decelerations Inside Host Galaxies?

    CERN Document Server

    Kawakatu, Nozomu; Kino, Motoki

    2008-01-01

    We examine the evolution of variously-sized radio galaxies [i.e., compact symmetric objects (CSOs), medium-size symmetric objects (MSOs), Fanaroff-Riley type II radio galaxies (FRIIs)], by comparing the relation between the hot spot size and the projected linear size with a coevolution model of hot spots and a cocoon. We take account of the deceleration effect by the cocoon head growth. We find that the advance speed of hot spots and lobes inevitably show the deceleration phase (CSO-MSO phase) and the acceleration phase (MSO-FRII phase). This is ascribed to the change of the power-law index of ambient density profile in the MSO phase ($\\sim $1 kpc). It is also found that the cocoon shape becomes nearly spherical or disrupted for MSOs, while an elongated morphology is predicted for CSOs and FRIIs. This seems to be consistent with the higher fraction of distorted morphology of MSOs than that of CSOs and FRI. Finally, we predict that only CSOs whose initial advance speed is higher than about 0.1c can evolve into...

  18. Periodic components of hand acceleration/deceleration impulses during telemanipulation

    Energy Technology Data Exchange (ETDEWEB)

    Draper, J.V. [Oak Ridge National Lab., TN (United States); Handel, S. [Tennessee Univ., Knoxville, TN (United States). Dept. of Psychology

    1994-01-01

    Responsiveness is the ability of a telemanipulator to recreate user trajectories and impedance in time and space. For trajectory production, a key determinant of responsiveness is the ability of the system to accept user inputs, which are forces on the master handle generated by user hand acceleration/deceleration (a/d) impulses, and translate them into slave arm acceleration/deceleration. This paper presents observations of master controller a/d impulses during completion of a simple target acquisition task. Power spectral density functions (PSDF`s) calculated from hand controller a/d impulses were used to assess impulse waveform. The relative contributions of frequency intervals ranging up to 25 Hz for three spatially different versions of the task were used to determine which frequencies were most important. The highest relative power was observed in frequencies between 1 Hz and 6 Hz. The key frequencies related to task difficulty were in the range from 2 Hz to 8 Hz. the results provide clues to the source of the performance inhibition.

  19. Beam Measurement Systems for the CERN Antiproton Decelerator (AD)

    CERN Document Server

    Angoletta, Maria Elena; Ludwig, M; Marqversen, O; Odier, P; Pedersen, F; Raich, U; Søby, L; Tranquille, G; Spickermann, T

    2001-01-01

    The new, low-energy antiproton physics facility at CERN has been successfully commissioned and has been delivering decelerated antiprotons at 100 MeV/c since July 2000. The AD consists of one ring where the 3.5 GeV/c antiprotons produced from a production target are injected, rf manipulated, stochastically cooled, decelerated (with further stages involving additional stochastic and electron cooling and rf manipulation) and extracted at 100 MeV/c. While proton test beams of sufficient intensity could be used for certain procedures in AD commissioning, this was not possible for setting-up and routine operation. Hence, special diagnostics systems had to be developed to obtain the beam and accelerator characteristics using the weak antiproton beams of a few 10E7 particles at all momenta from 3.5 GeV/c down to 100 MeV/c. These include systems for position measurement, intensity, beam size measurements using transverse aperture limiters and scintillators and Schottky-based tools. This paper gives an overall view of...

  20. Asymmetric acceleration/deceleration dynamics in heart rate variability

    Science.gov (United States)

    Alvarez-Ramirez, J.; Echeverria, J. C.; Meraz, M.; Rodriguez, E.

    2017-08-01

    The heart rate variability (HRV) is an important physiological signal used either to assess the risk of cardiac death or to model the cardiovascular regulatory dynamics. Asymmetries in HRV data have been observed using 2D Poincare plots, which have been linked to a non-equilibrium operation of the cardiac autonomic system. This work further explores the presence of asymmetries but in the serial correlations of the dynamics of HRV data. To this end, detrended fluctuation analysis (DFA) was used to estimate the Hurst exponent both when the heart rate is accelerating and when it is decelerating. The analysis is conducted using data collected from subjects under normal sinus rhythm (NSR), congestive heart failure (CHF) and atrial fibrillation (AF) . For the NSR cases, it was found that correlations are stronger (p heart rate is accelerating than when it is decelerating over different scales in the range 20-40 beats. In contrast, the opposite behavior was detected for the CHF and AF patients. Possible links between asymmetric correlations in the dynamics and the mechanisms controlling the operation of the heart rate are discussed, as well as their implications for modeling the cardiovascular regulatory dynamics.

  1. Ecological causes of decelerating diversification in carnivoran mammals.

    Science.gov (United States)

    Machac, Antonin; Storch, David; Wiens, John J

    2013-08-01

    Clade diversification is a central topic in macroevolutionary studies. Recently, it has been shown that diversification rates appear to decelerate over time in many clades. What causes this deceleration remains unclear, but it has been proposed that competition for limited resources between sympatric, ecologically similar species slows diversification. Employing carnivoran mammals as a model system, we test this hypothesis using a comprehensive time-calibrated phylogeny. We also explore several conceptually related explanations including limited geographic area and limited rates of niche evolution. We find that diversification slowdowns are strong in carnivorans. Surprisingly, these slowdowns are independent of geographic range overlap between related species and are also decoupled from rates of niche evolution, suggesting that slowdowns are unrelated to competition and niche filling. When controlling for the effects of clade diversity, diversification slowdowns appear independent of geographic area. There is a significant effect of clade diversity on diversification slowdowns, but simulations show that this relationship may arise as a statistical artifact (i.e., greater clade diversity increases the ability of the gamma statistic to refute constant diversification). Overall, our results emphasize the need to test hypotheses about the causes of diversification slowdowns with ecological data, rather than assuming ecological processes from phylogenies alone.

  2. Principles and design of a Zeeman-Sisyphus decelerator for molecular beams

    CERN Document Server

    Fitch, N J

    2016-01-01

    We explore a technique for decelerating molecules using a static magnetic field and optical pumping. Molecules travel through a spatially varying magnetic field and are repeatedly pumped into a weak-field seeking state as they move towards each strong field region, and into a strong-field seeking state as they move towards weak field. The method is time-independent and so is suitable for decelerating both pulsed and continuous molecular beams. By using guiding magnets at each weak field region, the beam can be simultaneously guided and decelerated. By tapering the magnetic field strength in the strong field regions, and exploiting the Doppler shift, the velocity distribution can be compressed during deceleration. We develop the principles of this deceleration technique, provide a realistic design, use numerical simulations to evaluate its performance for a beam of CaF, and compare this performance to other deceleration methods.

  3. Deceleration of a supersonic beam of SrF molecules to 120 m/s

    CERN Document Server

    Mathavan, S C; Esajas, Q; Hoekstra, S

    2016-01-01

    We report on the deceleration of a beam of SrF molecules from 290 to 120~m/s. Following supersonic expansion, the molecules in the $X^2\\Sigma$ ($v=0$, $N=1$) low-field seeking states are trapped by the moving potential wells of a traveling-wave Stark decelerator. With a deceleration strength of 9.6 km/s$^2$ we have demonstrated the removal of 85 % of the initial kinetic energy in a 4 meter long modular decelerator. The absolute amount of kinetic energy removed is a factor 1.5 higher compared to previous Stark deceleration experiments. The demonstrated decelerator provides a novel tool for the creation of highly collimated and slow beams of heavy diatomic molecules, which serve as a good starting point for high-precision tests of fundamental physics.

  4. On the deceleration of relativistic jets in active galactic nuclei I: Radiation drag

    CERN Document Server

    Beskin, V S

    2016-01-01

    Deceleration of relativistic jets from active galactic nuclei (AGNs) detected recently by MOJAVE team is discussed in connection with the interaction of the jet material with the external photon field. Appropriate energy density of the isotropic photon field which is necessary to decelerate jets is determined. It is shown that the disturbances of the electric potential and magnetic surfaces play important role in general dynamics of particle deceleration.

  5. On the deceleration of relativistic jets in active galactic nuclei- I. Radiation drag

    Science.gov (United States)

    Beskin, V. S.; Chernoglazov, A. V.

    2016-12-01

    Deceleration of relativistic jets from active galactic nuclei (AGNs) detected recently by the Monitoring Of Jets in Active galactic nuclei with Very Long Baseline Array Experiments (MOJAVE) team is discussed in connection with the interaction of the jet material with an external photon field. The appropriate energy density of the isotropic photon field necessary to decelerate jets is determined. It is shown that disturbances of the electric potential and magnetic surfaces play an important role in the general dynamics of particle deceleration.

  6. Hot Oxygen Corona at Mars and Its Effect on Solar Wind Deceleration

    Institute of Scientific and Technical Information of China (English)

    ZHANG Tie-Long; Lichtenegger Herbert; SHI Jian-Kui; WANG Xiao; Lammer Helmut

    2006-01-01

    @@ Phobos 2 plasma measurements have revealed solar wind deceleration of about 100 km/s upstream of the Martian bow shock. It is suggested that the deceleration is due to the mass loading by the ions originating from the hot oxygen corona of Mars. In this study, we use a gas-dynamic model to estimate the solar wind deceleration caused by the mass loading effect and the result shows that the deceleration is only about 10-15 km/s when we invoke the well established hot oxygen corona density profiles.

  7. Deceleration project bursts out of the starting-blocks

    CERN Multimedia

    Anaïs Schaeffer

    2011-01-01

    The starter's pistol was fired for the ELENA project on 28 September, with the kick-off meeting organised in collaboration with the Antiproton Decelerator Users Committee. With more than 90 scientists in attendance from 20 research centres throughout the world expressing their enthusiasm for the project…and some even more than that... the meeting was a great success.   "Our kick-off meeting was a really great success," says Stéphan Maury of the Beams (BE) Department, who is responsible for the ELENA (Extra Low ENergy Antiproton ring) project. PH Department's Walter Oelert, Chairman of the AD Users Committee and one of the instigators of the project, adds: "More than 90 participants showed up, over twice the number we were expecting! They were all very enthusiastic and eager to get ELENA off the ground." The meeting was attended by representatives of some twenty institutes from across the globe, all of whom had come to bl...

  8. Coherent Scalar Field Oscillations and the Epoch of Deceleration

    CERN Document Server

    Jackson, J C

    2001-01-01

    The discovery of supernova SN 1997ff at z~1.7 has confirmed the expected switch from cosmological acceleration to deceleration, as predicted by the concordance Lambda/CDM model. However, its position in the SN Ia Hubble diagram suggestes that the switch is too pronounced, which here is taken to mean that a cosmological constant is not an adequate description of the state of the vacuum. An 'oscillessence' model is invoked, with a scalar field phi governed by a simple quadratic potential, which gives a better fit to the new data point. The field is undergoing coherent oscillations, and a key feature of the proposal is that we are towards the end of the second period of acceleration; a Lambda/phi mix replaces Lambda/CDM, with Omega_Lambda~0.4 and Omega_phi~0.6.

  9. Instrumentation Development for Large Scale Hypersonic Inflatable Aerodynamic Decelerator Characterization

    Science.gov (United States)

    Swanson, Gregory T.; Cassell, Alan M.

    2011-01-01

    Hypersonic Inflatable Aerodynamic Decelerator (HIAD) technology is currently being considered for multiple atmospheric entry applications as the limitations of traditional entry vehicles have been reached. The Inflatable Re-entry Vehicle Experiment (IRVE) has successfully demonstrated this technology as a viable candidate with a 3.0 m diameter vehicle sub-orbital flight. To further this technology, large scale HIADs (6.0 8.5 m) must be developed and tested. To characterize the performance of large scale HIAD technology new instrumentation concepts must be developed to accommodate the flexible nature inflatable aeroshell. Many of the concepts that are under consideration for the HIAD FY12 subsonic wind tunnel test series are discussed below.

  10. Forest volume and biomass estimation using small-footprint lidar-distributional parameters on a per-segment basis

    CSIR Research Space (South Africa)

    Van Aardt, JAN

    2006-05-01

    Full Text Available This study assessed a lidar-based, object-oriented (segmentation) approach to forest volume and aboveground biomass modeling. The study area in the Piedmont physiographic region of Virginia is composed of temperate coniferous, deciduous, and mixed...

  11. SU-E-T-143: Effect of X-Ray and Cone Beam CT Reconstruction Parameters On Estimation of Bone Volume of Mice Used in Aging Research

    Energy Technology Data Exchange (ETDEWEB)

    Russ, M; Pang, M; Troen, B; Rudin, S; Ionita, C [University at Buffalo, Buffalo, NY (United States)

    2014-06-01

    Purpose: To investigate the variations in bone volume calculations in mice involved in aging research when changing cone beam micro-CT x-ray and reconstruction parameters. Methods: Mouse spines were placed on an indexed turn table that rotated 0.5° per projection and imaged by a self-built micro CT machine containing a CCD-based high-resolution x-ray detector. After the full 360° rotation data set of object images was obtained, a standard filtered back-projection cone beam reconstruction was performed. Four different kVp's between 40–70 kVp in 10kVp increments were selected. For each kVp two mAs settings were used. Each acquisition was reconstructed using two voxel sizes (12 and 25μm) and two step angles, 0.5° and 1°, respectively. A LabView program was written to determine the total bone volume contained in the mouse's total spine volume (bone plus gaps) as a measure of spine health. First, the user selected the desired 512×512 reconstruction to view the whole spine volume which was then used to select a gray-level threshold that allowed for viewing of the bone structure, then another threshold to include gaps. The program returned bone volume, bone × gap volume, and their ratio, BVF. Results: The calculated bone volume fractions were compared as a function of tube potential. Cases with 25μm slice thickness showed trials with lower kVp's had greater image contrast, which resulted in higher calculated bone volume fractions. Cases with 12μm reconstructed slice thickness were significantly noisier, and showed no clear maximum BVF. Conclusion: Using the projection images and reconstructions acquired from the micro CT, it can be shown that the micro-CT x-ray and reconstruction parameters significantly affect the total bone volume calculations. When comparing mice cohorts treated with different therapies researchers need to be aware of such details and use volumes which were acquired and processed in identical conditions.

  12. Influence of anodization parameters on the volume expansion of anodic aluminum oxide formed in mixed solution of phosphoric and oxalic acids

    Science.gov (United States)

    Kao, Tzung-Ta; Chang, Yao-Chung

    2014-01-01

    The growth of anodic alumina oxide was conducted in the mixed solution of phosphoric and oxalic acids. The influence of anodizing voltage, electrolyte temperature, and concentration of phosphoric and oxalic acids on the volume expansion of anodic aluminum oxide has been investigated. Either anodizing parameter is chosen to its full extent of range that allows the anodization process to be conducted without electric breakdown and to explore the highest possible volume expansion factor. The volume expansion factors were found to vary between 1.25 and 1.9 depending on the anodizing parameters. The variation is explained in connection with electric field, ion transport number, temperature effect, concentration, and activity of acids. The formation of anodic porous alumina at anodizing voltage 160 V in 1.1 M phosphoric acid mixed with 0.14 M oxalic acid at 2 °C showed the peak volume expansion factor of 1.9 and the corresponding moderate growth rate of 168 nm/min.

  13. Stereological estimation of nuclear volume and other quantitative histopathological parameters in the prognostic evaluation of supraglottic laryngeal squamous cell carcinoma

    DEFF Research Database (Denmark)

    Sørensen, Flemming Brandt; Bennedbaek, O; Pilgaard, J;

    1989-01-01

    observers of the latter was poor in the material which consisted of 35 biopsy specimens. Unbiased estimates of nuclear Vv were on the average 385 microns3 (CV = 0.44), with more than 90% of the associated variance attributable to differences in nuclear Vv among individual lesions. Nuclear Vv was positively......The aim of this study was to investigate various approaches to the grading of malignancy in pre-treatment biopsies from patients with supraglottic laryngeal squamous cell carcinoma. The prospects of objective malignancy grading based on stereological estimation of the volume-weighted mean nuclear...... volume, nuclear Vv, and nuclear volume fraction, Vv(nuc/tis), along with morphometrical 2-dimensional estimation of nuclear density index, NI, and mitotic activity index, MI, were investigated and compared with the current morphological, multifactorial grading system. The reproducibility among two...

  14. Guidebook for performance assessment parameters used in the Waste Isolation Pilot Plant compliance certification application. Volume 1: Main report

    Energy Technology Data Exchange (ETDEWEB)

    Howarth, S.M.; Martell, M.A.; Weiner, R. [Sandia National Labs., Albuquerque, NM (United States); Lattier, C. [GRAM, Inc., Albuquerque, NM (United States)

    1998-06-01

    The Waste Isolation Pilot Plant (WIPP) Compliance Certification Application (CCA) Performance Assessment (PA) Parameter Database and its ties to supporting information evolved over the course of two years. When the CCA was submitted to the Environmental Protection Agency (EPA) in October 1996, information such as identification of parameter value or distribution source was documented using processes established by Sandia National Laboratories WIPP Quality Assurance Procedures. Reviewers later requested additional supporting documentation, links to supporting information, and/or clarification for many parameters. This guidebook is designed to document a pathway through the complex parameter process and help delineate flow paths to supporting information for all WIPP CCA parameters. In addition, this report is an aid for understanding how model parameters used in the WIPP CCA were developed and qualified. To trace the source information for a particular parameter, a dual-route system was established. The first route uses information from the Parameter Records Package as it existed when the CCA calculations were run. The second route leads from the EPA Parameter Database to additional supporting information.

  15. Guidebook for performance assessment parameters used in the Waste Isolation Pilot Plant compliance certification application. Volume 2: Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Howarth, S.M.; Martell, M.A.; Weiner, R. [Sandia National Labs., Albuquerque, NM (United States); Lattier, C. [GRAM, Inc., Albuquerque, NM (United States)

    1998-06-01

    The Waste Isolation Pilot Plant (WIPP) Compliance Certification Application (CCA) Performance Assessment (PA) Parameter Database and its ties to supporting information evolved over the course of two years. When the CCA was submitted to the Environmental Protection Agency (EPA) in October 1996, information such as identification of parameter value or distribution source was documented using processes established by Sandia National Laboratories WIPP Quality Assurance Procedures. Reviewers later requested additional supporting documentation, links to supporting information, and/or clarification for many parameters. This guidebook is designed to document a pathway through the complex parameter process and help delineate flow paths to supporting information for all WIPP CCA parameters. In addition, this report is an aid for understanding how model parameters used in the WIPP CCA were developed and qualified. To trace the source information for a particular parameter, a dual-route system was established. The first route uses information from the Parameter Records package as it existed when the CCA calculations were run. The second route leads from the EPA Parameter Database to additional supporting information.

  16. Dose-volume parameters and clinical outcome of CT-guided free-hand high-dose-rate interstitial brachytherapy for cervical cancer

    Science.gov (United States)

    Wang, Yi; Ye, Wei-Jun; Du, Le-Hui; Li, Ai-Ju; Ren, Yu-Feng; Cao, Xin-Ping

    2012-01-01

    Currently, image-based 3-dimentional (3D) planning brachytherapy allows for a better assessment of gross tumor volume (GTV) and the definition and delineation of target volume in cervix cancer. In this study, we investigated the feasibility of our novel computed tomography (CT)-guided free-hand high-dose-rate interstitial brachytherapy (HDRISBT) technique for cervical cancer by evaluating the dosimetry and preliminary clinical outcome of this approach. Dose-volume histogram (DVH) parameters were analyzed according to the Gynecological GEC-ESTRO Working Group recommendations for image-based 3D treatment in cervical cancer. Twenty cervical cancer patients who underwent CT-guided free-hand HDRISBT between March 2009 and June 2010 were studied. With a median of 5 (range, 4–7) implanted needles for each patient, the median dose of brachytherapy alone delivered to 90% of the target volume (D90) was 45 (range, 33–54) Gyα/β10 for high-risk clinical target volume (HR-CTV) and 30 (range, 20–36) Gyα/β10 for intermediate-risk clinical target volume (IR-CTV). The percentage of the CTV covered by the prescribed dose (V100) of HR-CTV with brachytherapy alone was 81.9%–99.2% (median, 96.7%). With an additional dose of external beam radiotherapy (EBRT), the median D90 was 94 (range, 83–104) Gyα/β10 for HR-CTV and 77 (range, 70–87) Gyα/β10 for IR-CTV; the median dose delivered to 100% of the target volume (D100) was 75 (range, 66–84) Gyα/β10 for HR-CTV and 65 (range, 57–73) Gyα/β10 for IR-CTV. The minimum dose to the most irradiated 2 cc volume (D2cc) was 73–96 (median, 83) Gyα/β3 for the bladder, 64–98 (median, 73) Gyα/β3 for the rectum, and 52–69 (median, 61) Gyα/β3 for the sigmoid colon. After a median follow-up of 15 months (range, 3–24 months), two patients experienced local failure, and 1 showed internal iliac nodal metastasis. Despite the relatively small number of needles used, CT-guided HDRISBT for cervical cancer showed favorable

  17. Dose-volume parameters and clinical outcome of CT-guided freehand high-dose-rate interstitial brachytherapy for cervical cancer

    Institute of Scientific and Technical Information of China (English)

    Yi Wang; Wei-Jun Ye; Le-Hui Du; Ai-Ju Li; Yu-Feng Ren; Xin-Ping Cao

    2012-01-01

    Currently,image-based 3-dimentional (3D) planning brachytherapy allows for a better assessment of gross tumor volume (GTV) and the definition and delineation of target volume in cervix cancer.In this study,we investigated the feasibility of our novel computed tomography (CT)-guided free-hand high-doserate interstitial brachytherapy (HDRISBT) technique for cervical cancer by evaluating the dosimetry and preliminary clinical outcome of this approach.Dose-volume histogram (DVH) parameters were analyzed according to the Gynecological GEC-ESTRO Working Group recommendations for image-based 3D treatment in cervical cancer.Twenty cervical cancer patients who underwent CT-guided free-hand HDRISBT between March 2009 and June 2010 were studied.With a median of 5 (range,4-7) implanted needles for each patient,the median dose of brachytherapy alone delivered to 90% of the target volume (D90) was 45 (range,33-54) Gyα/β10 for high-risk clinical target volume (HR-CTV) and 30 (range,20-36)Gyα/β10 for intermediate-risk clinical target volume (IR-CTV).The percentage of the CTV covered by the prescribed dose (V100) of HR-CTV with brachytherapy alone was 81.9%-99.2% (median,96.7%).With an additional dose of external beam radiotherapy (EBRT),the median D90 was 94 (range,83-104) Gyα/β10 for HR-CTV and 77 (range,70-87) Gyα/β10 for IR-CTV; the median dose delivered to 100% of the target volume (D100) was 75 (range,66-84) Gyα/β10 for HR-CTV and 65 (range,57-73) Gyα/β10 for IR-CTV.The minimum dose to the most irradiated 2 cc volume (D2cc) was 73-96 (median,83) Gyα/β3 for the bladder,64-98 (median,73) Gyα/β3 for the rectum,and 52-69 (median,61) Gyα/β3 for the sigmoid colon.After a median follow-up of 15 months (range,3-24 months),two patients experienced local failure,and 1 showed internal lilac nodal metastasis.Despite the relatively small number of needles used,CT-guided HDRISBT for cervical cancer showed favorable DVH parameters and clinical outcome.

  18. View of the CERN Antiproton Decelerator (AD) and portrait of Prof. Tommy Eriksson, in charge of the AD machine.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    The Antiproton Decelerator (AD) is a storage ring at the CERN laboratory in Geneva. It started operation in 2000. It decelerates antiprotons before sending them to several experiments studying antimatter : ALPHA, ASACUSA, ATRAP and ACE.

  19. The effect of CT scanner parameters and 3D volume rendering techniques on the accuracy of linear, angular, and volumetric measurements of the mandible

    Science.gov (United States)

    Whyms, B.J.; Vorperian, H.K.; Gentry, L.R.; Schimek, E.M.; Bersu, E.T.; Chung, M.K.

    2013-01-01

    Objectives This study investigates the effect of scanning parameters on the accuracy of measurements from three-dimensional multi-detector computed tomography (3D-CT) mandible renderings. A broader range of acceptable parameters can increase the availability of CT studies for retrospective analysis. Study Design Three human mandibles and a phantom object were scanned using 18 combinations of slice thickness, field of view, and reconstruction algorithm and three different threshold-based segmentations. Measurements of 3D-CT models and specimens were compared. Results Linear and angular measurements were accurate, irrespective of scanner parameters or rendering technique. Volume measurements were accurate with a slice thickness of 1.25 mm, but not 2.5 mm. Surface area measurements were consistently inflated. Conclusions Linear, angular and volumetric measurements of mandible 3D-CT models can be confidently obtained from a range of parameters and rendering techniques. Slice thickness is the primary factor affecting volume measurements. These findings should also apply to 3D rendering using cone-beam-CT. PMID:23601224

  20. Flexible Thermal Protection System Development for Hypersonic Inflatable Aerodynamic Decelerators

    Science.gov (United States)

    DelCorso, Joseph A.; Bruce, Walter E., III; Hughes, Stephen J.; Dec, John A.; Rezin, Marc D.; Meador, Mary Ann B.; Guo, Haiquan; Fletcher, Douglas G.; Calomino, Anthony M.; Cheatwood, McNeil

    2012-01-01

    The Hypersonic Inflatable Aerodynamic Decelerators (HIAD) project has invested in development of multiple thermal protection system (TPS) candidates to be used in inflatable, high downmass, technology flight projects. Flexible TPS is one element of the HIAD project which is tasked with the research and development of the technology ranging from direct ground tests, modelling and simulation, characterization of TPS systems, manufacturing and handling, and standards and policy definition. The intent of flexible TPS is to enable large deployable aeroshell technologies, which increase the drag performance while significantly reducing the ballistic coefficient of high-mass entry vehicles. A HIAD requires a flexible TPS capable of surviving aerothermal loads, and durable enough to survive the rigors of construction, handling, high density packing, long duration exposure to extrinsic, in-situ environments, and deployment. This paper provides a comprehensive overview of key work being performed within the Flexible TPS element of the HIAD project. Included in this paper is an overview of, and results from, each Flexible TPS research and development activity, which includes ground testing, physics-based thermal modelling, age testing, margins policy, catalysis, materials characterization, and recent developments with new TPS materials.

  1. Cosmographic bounds on the cosmological deceleration-acceleration transition redshift in $f(\\mathcal{R})$ gravity

    CERN Document Server

    Capozziello, Salvatore; Luongo, Orlando; Ratra, Bharat

    2014-01-01

    We examine the observational viability of a class of $f(\\mathcal{R})$ gravity cosmological models. Particular attention is devoted to constraints from the recent observational determination of the redshift of the cosmological deceleration-acceleration transition. Making use of the fact that the Ricci scalar is a function of redshift $z$ in these models, $\\mathcal {R=R}(z)$, and so is $f(z)$, we use cosmography to relate a $f(z)$ test function evaluated at higher $z$ to late-time cosmographic bounds. First, we consider a model independent procedure to build up a numerical $f(z)$ by requiring that at $z=0$ the corresponding cosmological model reduces to standard $\\Lambda$CDM. We then infer late-time observational constraints on $f(z)$ in terms of bounds on the Taylor expansion cosmographic coefficients. In doing so we parameterize possible departures from the standard $\\Lambda$CDM model in terms of a two-parameter logarithmic correction. The physical meaning of the two parameters is also discussed in terms of t...

  2. Causes for torque degradation during deceleration and the effect on the driving range of battery electric vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Lieb, Johannes [BMW PEUGEOT CITROEN ELECTRIFICATION, Muenchen (Germany); Wilde, Andreas [BMW Group, Muenchen (Germany); Baeker, Bernard [Dresden Univ. of Technology (Germany). Dept. of Vehicle Mechatronics

    2012-11-01

    The ability to regain considerable amounts of the kinetic energy during deceleration phases is a key aspect to increase the efficiency of battery electric vehicles (BEV). Especially in urban and highly congested areas brake energy recovery (BER) can drastically improve the vehicle's driving range. However, due to the high power peaks that go along even with moderate braking maneuvers, severe requirements are being put on the electric drivetrain. Any limitation of power in one of the components of the powertrain inevitably leads to degradation of the regenerative brake torque, thus limiting the car's energy regeneration capability. Without an integrated brake system that can compensate the torque variations during deceleration, BER may need to be decreased even further to prevent a loss of driving comfort due to dynamic changes in the vehicle's behavior. This paper deals with the causes of these torque restraints within the electric drivetrain and how they affect the energy consumption and therefore the electric driving range. A simulation environment was set up and verified based on an existing BEV to conduct parameter studies and depict the sensitivities towards environmental influences. The calculated efficiencies are based on standard drive cycles and incorporate continuous fading between regenerative braking and the use of friction brakes. Special attention was laid on the battery system since energy storage still poses a particular challenge in the development of electric vehicles. Also through the high mutual dependence of the various parameters of the battery enviromental influences become most evident. (orig.)

  3. Fukushima Daiichi Unit 1 Uncertainty Analysis-Exploration of Core Melt Progression Uncertain Parameters-Volume II.

    Energy Technology Data Exchange (ETDEWEB)

    Denman, Matthew R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Brooks, Dusty Marie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    Sandia National Laboratories (SNL) has conducted an uncertainty analysi s (UA) on the Fukushima Daiichi unit (1F1) accident progression wit h the MELCOR code. Volume I of the 1F1 UA discusses the physical modeling details and time history results of the UA. Volume II of the 1F1 UA discusses the statistical viewpoint. The model used was developed for a previous accident reconstruction investigation jointly sponsored by the US Department of Energy (DOE) and Nuclear Regulatory Commission (NRC). The goal of this work was to perform a focused evaluation of uncertainty in core damage progression behavior and its effect on key figures - of - merit (e.g., hydrogen production, fraction of intact fuel, vessel lower head failure) and in doing so assess the applicability of traditional sensitivity analysis techniques .

  4. Effect of the volume of the drainage system on the measurement of undrained thermo-poro-elastic parameters

    CERN Document Server

    Ghabezloo, Siavash; 10.1016/j.ijrmms.2009.03.001

    2009-01-01

    For evaluation of the undrained thermo-poro-elastic properties of saturated porous materials in conventional triaxial cells, it is important to take into account the effect of the dead volume of the drainage system. The compressibility and the thermal expansion of the drainage system along with the dead volume of the fluid filling this system, influence the measured pore pressure and volumetric strain during an undrained thermal or mechanical loading in a triaxial cell. The correction methods previously presented by Wissa (1969), Bishop (1976) and Ghabezloo and Sulem (2009) only permit to correct the measured pore pressures during an undrained isotropic compression test or an undrained heating test. An extension of these methods is presented in this paper to correct also the measured volumetric strain and consequently the measured undrained bulk compressibility and undrained thermal expansion coefficients during these tests. Two examples of application of the proposed correction method are presented on the re...

  5. CFD Simulations of the Supersonic Inflatable Aerodynamic Decelerator (SIAD) Ballistic Range Tests

    Science.gov (United States)

    Brock, Joseph; Stern, Eric; Wilder, Michael

    2017-01-01

    A series of ballistic range tests were performed on a scaled model of the Supersonic Flight Demonstration Test (SFDT) intended to test the Supersonic Inflatable Aerodynamic Decelerator (SIAD) geometry. The purpose of these experiments were to provide aerodynamic coefficients of the vehicle to aid in mission and vehicle design. The experimental data spans the moderate Mach number range, $3.8-2.0$, with a total angle of attack ($alpha_T$) range, $10o-20o$. These conditions are intended to span the Mach-$alpha$ space for the majority of the SFDT experiment. In an effort to validate the predictive capabilities of Computational Fluid Dynamics (CFD) for free-flight aerodynamic behavior, numerical simulations of the ballistic range experiment are performed using the unstructured finite volume Navier-Stokes solver, US3D. Comparisons to raw vehicle attitude, and post-processed aerodynamic coefficients are made between simulated results and experimental data. The resulting comparisons for both raw model attitude and derived aerodynamic coefficients show good agreement with experimental results. Additionally, near body pressure field values for each trajectory simulated are investigated. Extracted surface and wake pressure data gives further insights into dynamic flow coupling leading to a potential mechanism for dynamic instability.

  6. Murine Glut-1 transporter haploinsufficiency: postnatal deceleration of brain weight and reactive astrocytosis.

    Science.gov (United States)

    Ullner, Paivi M; Di Nardo, Alessia; Goldman, James E; Schobel, Scott; Yang, Hong; Engelstad, Kristin; Wang, Dong; Sahin, Mustafa; De Vivo, Darryl C

    2009-10-01

    Glucose transporter type 1 (Glut-1) facilitates glucose flux across the blood-brain-barrier. In humans, Glut-1 deficiency causes acquired microcephaly, seizures and ataxia, which are recapitulated in our Glut-1 haploinsufficient mouse model. Postnatal brain weight deceleration and development of reactive astrogliosis were significant by P21 in Glut-1(+/-) mice. The brain weight differences remained constant after P21 whereas the reactive astrocytosis continued to increase and peaked at P90. Brain immunoblots showed increased phospho-mTOR and decreased phospho-GSK3-beta by P14. After fasting, the mature Glut-1(+/-) females showed a trend towards elevated phospho-GSK3-beta, a possible neuroprotective response. Lithium chloride treatment of human skin fibroblasts from control and Glut-1 DS patients produced a 45% increase in glucose uptake. Brain imaging of mature Glut-1(+/-) mice revealed a significantly decreased hippocampal volume. These subtle immunochemical changes reflect chronic nutrient deficiency during brain development and represent the experimental correlates to the human neurological phenotype associated with Glut-1 DS.

  7. Changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke

    Directory of Open Access Journals (Sweden)

    Xu YH

    2016-03-01

    Full Text Available Yan-Hong Xu,1 Xing-De Wang,2 Jia-Jun Yang,1 Li Zhou,2 Yong-Chao Pan1 1Department of Neurology, 2Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China Background and purpose: Autonomic dysfunction is common after stroke, which is correlated with unfavorable outcome. Phase-rectified signal averaging is a newly developed technique for assessing cardiac autonomic function, by detecting sympathetic and vagal nerve activity separately through calculating acceleration capacity (AC and deceleration capacity (DC of heart rate. In this study, we used this technique for the first time to investigate the cardiac autonomic function of patients with acute hemispheric ischemic stroke. Methods: A 24-hour Holter monitoring was performed in 63 patients with first-ever acute ischemic stroke in hemisphere and sinus rhythm, as well as in 50 controls with high risk of stroke. DC, AC, heart rate variability parameters, standard deviation of all normal-to-normal intervals (SDNN, and square root of the mean of the sum of the squares of differences between adjacent normal-to-normal intervals (RMSSD were calculated. The National Institutes of Health Stroke Scale (NIHSS was used to assess the severity of stroke. We analyzed the changes of DC, AC, SDNN, and RMSSD and also studied the correlations between these parameters and NIHSS scores. Results: The R–R (R wave to R wave on electrocardiogram intervals, DC, AC, and SDNN in the cerebral infarction group were lower than those in controls (P=0.003, P=0.002, P=0.006, and P=0.043, but the difference of RMSSD and the D-value and ratio between absolute value of AC (|AC| and DC were not statistically significant compared with those in controls. The DC of the infarction group was significantly correlated with |AC|, SDNN, and RMSSD (r=0.857, r=0.619, and r=0.358; P=0.000, P=0.000, and P=0.004. Correlation analysis also showed that DC, |AC|, and SDNN

  8. Bianchi type-V dark energy model with varying EoS parameter

    CERN Document Server

    Saha, Bijan

    2012-01-01

    Within the scope of an anisotropic Bianchi type-V cosmological model we have studied the evolution of the universe. The assumption of a diagonal energy-momentum tensor leads to some severe restriction on the metric functions, which on its part imposes restriction on the components of the energy momentum tensor. This model allows anisotropic matter distribution. Further using the proportionality condition that relates the shear scalar $(\\sigma)$ in the model is proportional to expansion scalar $(\\vartheta)$ and the variation law of Hubble parameter, connecting Hubble parameter with volume scale. Exact solution to the corresponding equations are obtained. The EoS parameter for dark energy as well as deceleration parameter is found to be the time varying functions. A qualitative picture of the evolution of the universe corresponding to different of its stages is given using the latest observational data.

  9. Impact of ribs on flow parameters and laminar heat transfer of water–aluminum oxide nanofluid with different nanoparticle volume fractions in a three-dimensional rectangular microchannel

    Directory of Open Access Journals (Sweden)

    Omid Ali Akbari

    2015-11-01

    Full Text Available This article aims to study the impact of ribs on flow parameters and laminar heat transfer of water–aluminum oxide nanofluid with different nanoparticle volume fractions in a three-dimensional rectangular microchannel. To this aim, compulsory convection heat transfer of water–aluminum oxide nanofluid in a rib-roughened microchannel has been numerically studied. The results of this simulation for rib-roughened three-dimensional microchannel have been evaluated in contrast to the smooth (unribbed three-dimensional microchannel with identical geometrical and heat–fluid boundary conditions. Numerical simulation is performed for different nanoparticle volume fractions for Reynolds numbers of 10 and 100. Cold fluid entering the microchannel is heated in order to apply constant flux to external surface of the microchannel walls and then leaves it. Given the results, the fluid has a higher heat transfer with a hot wall in surfaces with ribs rather than in smooth ones. As Reynolds number, number of ribs, and nanoparticle volume fractions increase, more temperature increase happens in fluid in exit intersection of the microchannel. By investigating Nusselt number and friction factor, it is observed that increase in nanoparticle volume fractions causes nanofluid heat transfer properties to have a higher heat transfer and friction factor compared to the base fluid used in cooling due to an increase in viscosity.

  10. Measurement of track structure parameters of low and medium energy helium and carbon ions in nanometric volumes

    Science.gov (United States)

    Hilgers, G.; Bug, M. U.; Rabus, H.

    2017-10-01

    Ionization cluster size distributions produced in the sensitive volume of an ion-counting wall-less nanodosimeter by monoenergetic carbon ions with energies between 45 MeV and 150 MeV were measured at the TANDEM-ALPI ion accelerator facility complex of the LNL-INFN in Legnaro. Those produced by monoenergetic helium ions with energies between 2 MeV and 20 MeV were measured at the accelerator facilities of PTB and with a 241Am alpha particle source. C3H8 was used as the target gas. The ionization cluster size distributions were measured in narrow beam geometry with the primary beam passing the target volume at specified distances from its centre, and in broad beam geometry with a fan-like primary beam. By applying a suitable drift time window, the effective size of the target volume was adjusted to match the size of a DNA segment. The measured data were compared with the results of simulations obtained with the PTB Monte Carlo code PTra. Before the comparison, the simulated cluster size distributions were corrected with respect to the background of additional ionizations produced in the transport system of the ionized target gas molecules. Measured and simulated characteristics of the particle track structure are in good agreement for both types of primary particles and for both types of the irradiation geometry. As the range in tissue of the ions investigated is within the typical extension of a spread-out Bragg peak, these data are useful for benchmarking not only ‘general purpose’ track structure simulation codes, but also treatment planning codes used in hadron therapy. Additionally, these data sets may serve as a data base for codes modelling the induction of radiation damages at the DNA-level as they almost completely characterize the ionization component of the nanometric track structure.

  11. Comparison of long and short axis quantification of left ventricular volume parameters by cardiovascular magnetic resonance, with ex-vivo validation

    Directory of Open Access Journals (Sweden)

    Childs Helene

    2011-08-01

    Full Text Available Abstract Background The purpose of the study was to compare the accuracy and evaluation time of quantifying left ventricular (LV, left atrial (LA volume and LV mass using short axis (SAX and long axis (LAX methods when using cardiovascular magnetic resonance (CMR. Materials and methods We studied 12 explanted canine hearts and 46 patients referred for CMR (29 male, age 47 ± 18 years in a clinical 1.5 T CMR system, using standard cine sequences. In standard short axis stacks of various slice thickness values in dogs and 8 mm slice thickness (gap 2 mm in patients, we measured LV volumes using reference slices in a perpendicular, long axis orientation using certified software. Volumes and mass were also measured in six radial long axis (LAX views. LV parameters were also assessed for intra- and inter-observer variability. In 24 patients, we also analyzed reproducibility and evaluation time of two very experienced (> 10 years of CMR reading readers for SAX and LAX. Results In the explanted dog hearts, there was excellent agreement between ex vivo data and LV mass and volume data as measured by all methods for both, LAX (r2 = 0.98 and SAX (r2 = 0.88 to 0.98. LA volumes, however, were underestimated by 13% using the LAX views. In patients, there was a good correlation between all three assessed methods (r2 ≥ 0.95 for all. In experienced clinical readers, left-ventricular volumes and ejection fraction as measured in LAX views showed a better inter-observer reproducibility and a 27% shorter evaluation time. Conclusion When compared to an ex vivo standard, both, short axis and long axis techniques are highly accurate for the quantification of left ventricular volumes and mass. In clinical settings, however, the long axis approach may be more reproducible and more time-efficient. Therefore, the rotational long axis approach is a viable alternative for the clinical assessment of cardiac volumes, function and mass.

  12. Intra-lesional spatial correlation of static and dynamic FET-PET parameters with MRI-based cerebral blood volume in patients with untreated glioma

    Energy Technology Data Exchange (ETDEWEB)

    Goettler, Jens; Preibisch, Christine [TU Muenchen, Department of Neuroradiology, Klinikum rechts der Isar, Munich (Germany); TU Muenchen, TUM Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Munich (Germany); Lukas, Mathias; Mustafa, Mona; Schwaiger, Markus; Pyka, Thomas [TU Muenchen, Department of Nuclear Medicine, Klinikum rechts der Isar, Munich (Germany); Kluge, Anne; Kaczmarz, Stephan; Zimmer, Claus [TU Muenchen, Department of Neuroradiology, Klinikum rechts der Isar, Munich (Germany); Gempt, Jens; Ringel, Florian; Meyer, Bernhard [TU Muenchen, Department of Neurosurgery, Klinikum rechts der Isar, Munich (Germany); Foerster, Stefan [TU Muenchen, TUM Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Munich (Germany); TU Muenchen, Department of Nuclear Medicine, Klinikum rechts der Isar, Munich (Germany); Klinikum Bayreuth, Department of Nuclear Medicine, Bayreuth (Germany)

    2017-03-15

    {sup 18}F-fluorethyltyrosine-(FET)-PET and MRI-based relative cerebral blood volume (rCBV) have both been used to characterize gliomas. Recently, inter-individual correlations between peak static FET-uptake and rCBV have been reported. Herein, we assess the local intra-lesional relation between FET-PET parameters and rCBV. Thirty untreated glioma patients (27 high-grade) underwent simultaneous PET/MRI on a 3 T hybrid scanner obtaining structural and dynamic susceptibility contrast sequences. Static FET-uptake and dynamic FET-slope were correlated with rCBV within tumour hotspots across patients and intra-lesionally using a mixed-effects model to account for inter-individual variation. Furthermore, maximal congruency of tumour volumes defined by FET-uptake and rCBV was determined. While the inter-individual relationship between peak static FET-uptake and rCBV could be confirmed, our intra-lesional, voxel-wise analysis revealed significant positive correlations (median r = 0.374, p < 0.0001). Similarly, significant inter- and intra-individual correlations were observed between FET-slope and rCBV. However, rCBV explained only 12% of the static and 5% of the dynamic FET-PET variance and maximal overlap of respective tumour volumes was 37% on average. Our results show that the relation between peak values of MR-based rCBV and static FET-uptake can also be observed intra-individually on a voxel basis and also applies to a dynamic FET parameter, possibly determining hotspots of higher biological malignancy. However, just a small part of the FET-PET signal variance is explained by rCBV and tumour volumes determined by the two modalities showed only moderate overlap. These findings indicate that FET-PET and MR-based rCBV provide both congruent and complimentary information on glioma biology. (orig.)

  13. Relationship between activation volume and polymer matrix effects on photochromic performance: bridging molecular parameter to macroscale effect.

    Science.gov (United States)

    Shima, Kentaro; Mutoh, Katsuya; Kobayashi, Yoichi; Abe, Jiro

    2015-02-19

    Photochromic compounds have attracted attention as ophthalmic lenses because of their reversible color modulation upon irradiation with light. However, the efficiency of the photochromism is strongly affected by their surrounding because of the structural changes concomitant with the photochromism, which causes the decrease in the photochromic performance in the polymer matrix. Therefore, the clarification of the degree of the structural changes is necessary to apply to the ophthalmic lenses. Bridged imidazole dimers are one of the fast photoswitch molecules possessing high photochromic quantum yield and durability. Although the enhancement of the photochromic properties of bridged imidazole dimers has been vigorously studied, the quantitative information about the structural changes has not been revealed in detail. In this study, we investigated the pressure effects on the photochromic properties of bridged imidazole dimers. The activation volume for the thermal back-reaction of the photogenerated biradical species becomes an effective measure to predict the degree of the structural change during the photochromic reaction. We revealed that the smaller activation volume is suitable for keeping the efficient photochromic reaction in the polymer matrix because the photochromic reaction is not affected by the surroundings. These fundamental insights into the molecular dynamics provide valuable information to develop fast photochromic compounds that are suitable for the use in the polymer matrix and pressure sensitive photochromic materials.

  14. Dysphagia after definitive radiotherapy for head and neck cancer. Correlation of dose-volume parameters of the pharyngeal constrictor muscles

    Energy Technology Data Exchange (ETDEWEB)

    Deantonio, L.; Masini, L. [University Hospital ' Maggiore della Carita' , Novara (Italy). Radiotherapy; Brambilla, M. [University Hospital ' Maggiore della Carita' , Novara (Italy). Medical Physics; Pia, F. [University Hospital ' Maggiore della Carita' , Novara (Italy). Otolaryngology; University of ' Piemonte Orientale' , Novara (Italy). Dept. of Medical Sciences; Krengli, M. [University Hospital ' Maggiore della Carita' , Novara (Italy). Radiotherapy; University of ' Piemonte Orientale' , Novara (Italy). Dept. of Translational Medicine and BRMA

    2013-03-15

    Background: Dysphagia is a complication of head and neck cancer patients undergoing radiotherapy (RT). We analysed frequency and severity of swallowing dysfunction and correlated these findings with dose-volume histograms (DVHs) of the pharyngeal constrictor muscles. Methods: A total of 50 patients treated by radical RT were enrolled. DVHs of constrictor muscles were correlated with acute and late dysphagia and with the items of three quality of life questionnaires. Results: Mean dose to superior and middle constrictor muscles (SCM, MCM), partial volume of SCM and MCM receiving a dose {>=} 50 Gy dose to the whole constrictor muscles {>=} 60 Gy and tumour location were associated to late dysphagia at univariate analysis. Mean dose to the MCM was the only statistically significant predictor of late dysphagia at the multivariable analysis. Conclusion: The study shows a significant relationship between long-term dysphagia and mean doses to SCM, MCM, whole constrictor muscles, and oropharyngeal tumour. This finding suggests a potential advantage in reducing the RT dose to swallowing structures to avoid severe dysphagia. (orig.)

  15. Nanomolar ambient ATP decelerates P2X3 receptor kinetics.

    Science.gov (United States)

    Grote, Alexander; Hans, Michael; Boldogkoi, Zsolt; Zimmer, Andreas; Steinhäuser, Christian; Jabs, Ronald

    2008-12-01

    Homomeric P2X receptors differ in their electrophysiological and pharmacological profiles. The rapidly activating and desensitizing P2X3 receptors are known for their involvement in pain signalling pathways. Modulatory effects on P2X3 receptors have been reported for low concentrations of ATP ([ATP]). This includes both, enhancement and reduction of receptor currents. The first has been reported to be mediated by activation of ectoprotein kinases and high affinity desensitization (HAD), respectively. Both processes influence receptor current amplitudes. Here we describe a new phenomenon, the modulatory influence of ambient low [ATP] on P2X3 receptor kinetics. First, we studied in HEK cells whether persistent ATP affects current decay. To this end, P2X3 receptor mediated currents, elicited by pressure application of saturating [ATP], were analyzed after pre-application of low [ATP]. Second, UV-flash photolysis of ATP was employed to investigate whether submicromolar [ATP] affects receptor activation. Finally we confirmed the action of nanomolar [ATP] on native P2X3 receptors of neurons freshly isolated from rat dorsal root ganglia. We found that persistent low [ATP] caused pronounced deceleration of receptor current activation and decay. This priming effect indicates a mechanism different from HAD. It could be explained by a pre-opening receptor isomerization, induced by the occupation of a high affinity binding site already at the resting state. The observed modulation of the receptor kinetics could be considered as a physiological fine tuning mechanism of the nociceptive system, driven by the actual ambient agonist concentration.

  16. The Hubble diagram of metal-rich QSOs and deceleration parameter q0

    Institute of Scientific and Technical Information of China (English)

    谢光中; 梅东成; 郑广生; 樊军辉

    2001-01-01

    For 163 metal-rich Quasars, the mv-logZ diagram shows a very close correlation. Using multiple regression analysis for these sources ( N = 163), we obtained q0 = 1. 142 and correlation coef-ficient γ = 0.69. These results suggested that the Universe is closed and all metal-rich quasars are of a single category. On the other hand, the evolution is very small at Z≤2 for metal-rich quasars.

  17. The Effect of Dose-Volume Parameters and Interfraction Interval on Cosmetic Outcome and Toxicity After 3-Dimensional Conformal Accelerated Partial Breast Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Leonard, Kara Lynne, E-mail: karalynne.kerr@gmail.com [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts (United States); Hepel, Jaroslaw T. [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts (United States); Department of Radiation Oncology, Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, Rhode Island (United States); Hiatt, Jessica R. [Department of Radiation Oncology, Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, Rhode Island (United States); Dipetrillo, Thomas A. [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts (United States); Department of Radiation Oncology, Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, Rhode Island (United States); Price, Lori Lyn [Department of Biostatistics Research Center, Institute of Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts (United States); Wazer, David E. [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts (United States); Department of Radiation Oncology, Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, Rhode Island (United States)

    2013-03-01

    Purpose: To evaluate dose-volume parameters and the interfraction interval (IFI) as they relate to cosmetic outcome and normal tissue effects of 3-dimensional conformal radiation therapy (3D-CRT) for accelerated partial breast irradiation (APBI). Methods and Materials: Eighty patients were treated by the use of 3D-CRT to deliver APBI at our institutions from 2003-2010 in strict accordance with the specified dose-volume constraints outlined in the National Surgical Adjuvant Breast and Bowel Project B39/Radiation Therapy Oncology Group 0413 (NSABP-B39/RTOG 0413) protocol. The prescribed dose was 38.5 Gy in 10 fractions delivered twice daily. Patients underwent follow-up with assessment for recurrence, late toxicity, and overall cosmetic outcome. Tests for association between toxicity endpoints and dosimetric parameters were performed with the chi-square test. Univariate logistic regression was used to evaluate the association of interfraction interval (IFI) with these outcomes. Results: At a median follow-up time of 32 months, grade 2-4 and grade 3-4 subcutaneous fibrosis occurred in 31% and 7.5% of patients, respectively. Subcutaneous fibrosis improved in 5 patients (6%) with extended follow-up. Fat necrosis developed in 11% of women, and cosmetic outcome was fair/poor in 19%. The relative volume of breast tissue receiving 5%, 20%, 50%, 80%, and 100% (V5-V100) of the prescribed dose was associated with risk of subcutaneous fibrosis, and the volume receiving 50%, 80%, and 100% (V50-V100) was associated with fair/poor cosmesis. The mean IFI was 6.9 hours, and the minimum IFI was 6.2 hours. The mean and minimum IFI values were not significantly associated with late toxicity. Conclusions: The incidence of moderate to severe late toxicity, particularly subcutaneous fibrosis and fat necrosis and resulting fair/poor cosmesis, remains high with continued follow-up. These toxicity endpoints are associated with several dose-volume parameters. Minimum and mean IFI values were

  18. AN EXPERIMENTAL TECHNIQUE TO MEASURE PROJECTILE DECELERATION HISTORY DURING NORMAL PENETRATION

    Institute of Scientific and Technical Information of China (English)

    INTO PLAIN; Liu Xiaohu; Liu Ji; Wang Cheng

    2000-01-01

    The present paper presents a new experimental method to measure the deceleration time his tory of projectiles penetrating into concrete in full-size test. The experiment can be carried out by using an onboard accelerometer to measure the projectile deceleration history and the data are transmitted to a ground recording system. With this experimental method, a series of tests on hemisphere-nose steel projectiles pene trating normally into plain concrete at the velocity region 150 - 400 m/s have been executed and the deceler ation histories obtained. The high frequency portion in the deceleration data has been investigated and proved to be the structure response of projectile. The characteristics of deceleration history have also been analyzed and discussed.

  19. Research on cubic polynomial acceleration and deceleration control model for high speed NC machining

    Institute of Scientific and Technical Information of China (English)

    Hong-bin LENG; Yi-jie WU; Xiao-hong PAN

    2008-01-01

    To satisfy the need of high speed NC (numerical control) machining, an acceleration and deceleration (aec/dec) control model is proposed, and the speed curve is also constructed by the cubic polynomial. The proposed control model provides continuity of acceleration, which avoids the intense vibration in high speed NC machining. Based on the discrete characteristic of the data sampling interpolation, the acc/dec control discrete mathematical model is also set up and the discrete expression of the theoretical deceleration length is obtained furthermore. Aiming at the question of hardly predetermining the deceleration point in acc/dec control before interpolation, the adaptive acc/dec control algorithm is deduced from the expressions of the theoretical deceleration length. The experimental result proves that the acc/dec control model has the characteristic of easy implementation, stable movement and low impact. The model has been applied in multi-axes high speed micro fabrication machining successfully.

  20. Randomized Controlled Trial of High-Volume Energy Drink Versus Caffeine Consumption on ECG and Hemodynamic Parameters.

    Science.gov (United States)

    Fletcher, Emily A; Lacey, Carolyn S; Aaron, Melenie; Kolasa, Mark; Occiano, Andrew; Shah, Sachin A

    2017-04-26

    Caffeine in doses energy drinks. We evaluated the ECG and blood pressure (BP) effects of high-volume energy drink consumption compared with caffeine alone. This was a randomized, double-blind, controlled, crossover study in 18 young, healthy volunteers. Participants consumed either 946 mL (32 ounces) of energy drink or caffeinated control drink, both of which contained 320 mg of caffeine, separated by a 6-day washout period. ECG, peripheral BP, and central BP measurements were obtained at baseline and 1, 2, 4, 6, and 24 hours post study drink consumption. The time-matched, baseline-adjusted changes were compared. The change in corrected QT interval from baseline in the energy drink arm was significantly higher than the caffeine arm at 2 hours (0.44±18.4 ms versus -10.4±14.8 ms, respectively; P=0.02). The QTc changes were not different at other time points. While both the energy drink and caffeine arms raised systolic BP in a similar fashion initially, the systolic BP was significantly higher at 6 hours when compared with the caffeine arm (4.72±4.67 mm Hg versus 0.83±6.09 mm Hg, respectively; P=0.01). Heart rate, diastolic BP, central systolic BP, and central diastolic BP showed no evidence of a difference between groups at any time point. Post energy drink, augmentation index was lower at 6 hours. The corrected QT interval and systolic BP were significantly higher post high-volume energy drink consumption when compared with caffeine alone. Larger clinical trials validating these findings and evaluation of noncaffeine ingredients within energy drinks are warranted. URL: http://www.clinicaltrials.gov. Unique identifier: NCT02023723. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

  1. A cyclic behavior of CME accelerations for accelerating and decelerating events

    Institute of Scientific and Technical Information of China (English)

    Peng-Xin Gao; Ke-Jun Li

    2009-01-01

    We investigate the cyclic evolutionary behavior of CME accelerations for accelerating and decelerating CME events in cycle 23 from 1997 January to 2007 December.It is found that the absolute values of semiannual mean accelerations of both accelerating and decelerating CME events roughly wax and wane in a cycle,delaying the sunspot cycle in time phase.We also investigate the semiannual number of CMEs with positive and negative acceleration and find that there are more decelerating CME events than accelerating CME events during the maximum period of a cycle (about three years),but there are more accelerating CME events than decelerating CME events during the rest of the time interval of the cycle.Our results seem to suggest that the different driving mechanisms may be acting accelerate and decelerate CME events: for accelerating CME events,the propelling force (Fp) statistically seems to play a significant role in pushing CMEs outward;for decelerating CME events,the drag (F_d) statistically seems to play a more effective role in determining CME kinematic evolution in the outer corona.During the maximum period of a cycle,because of the V_2 dependence,Fd is generally stronger; because of the magnetic field dependence,Fp is also generally stronger.Thus,the absolute values of both the negative and positive accelerations are generally larger during that time.Because of the V2 dependence,Fd may be more effective during the maximum period of a cycle.Hence,there are more decelerating CME events than accelerating CME events during that time.During the minimum time interval of a cycle,CMEs have relatively small speeds,and Fp may be more effective.Therefore,there are more accelerating CME events than decelerating CME events during that time.

  2. EARTH’S ROTATIONAL DECELERATION: DETERMINATION OF TIDAL FRICTION INDEPENDENT OF TIMESCALES

    Energy Technology Data Exchange (ETDEWEB)

    Deines, Steven D. [Donatech Corporation, Fairfield, IA 52556 (United States); Williams, Carol A., E-mail: steven.deines@gmail.com, E-mail: cw@math.usf.edu [Department of Mathematics and Statistics (Prof. emeritus), University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620 (United States)

    2016-04-15

    This paper determines Earth's rotational deceleration without relying on atomic or ephemeris timescales. Earth's rotation defines the civil time standard called Universal Time (UT). Our previous paper did not examine tidal friction in depth when analyzing the timescale divergence between UT and International Atomic Time (TAI). We examine all available paleontological fossils and deposits for the direct measurements of Earth's past rotation rates, because that record includes all contributing effects. We examine paleontological reports that date Earth's rotation rate using corals, bivalves, brachiopods, rhythmites, and stromatolites. Contributions that vary Earth's moment of inertia, such as continental plate drifts, coastline changes, ice age formations, and viscous glacial rebounds, are superimposed with the secular deceleration. The average deceleration of Earth's rotation rate from all available fossil data is found to be (5.969 ± 1.762) × 10{sup −7} rad yr{sup −2}. Our value is 99.8% of the total rotational deceleration determined by Christodoulidis et al., who used artificial satellite data, and our value is 96.6% of the expected tidal friction value obtained by Stephenson and Morrison. Taking the derivative of conserved angular momentum, the predicted lunar orbital deceleration caused by the average rotational deceleration corresponds closely to lunar models. When evaluating the significant time gaps between UT and TAI, Earth's rotational deceleration is a minor contributing factor. Also, the secular deceleration rate is necessary to correctly date ancient astronomical events. We strongly encourage that more ocean paleontological evidence be found to supplement the record to separate the many periodic variations embedded in these data.

  3. Investigation of the Decelerating Field of an Electron Multiplier under Negative Ion Impact

    DEFF Research Database (Denmark)

    Larsen, Elfinn; Kjeldgaard, K.

    1973-01-01

    The effect of the decelerating field of an electron multiplier towards negative ions was investigated under standard mass spectrometric conditions. Diminishing of this decelerating field by changing of the potential of the electron multiplier increased the overall sensitivity to negative ions...... by a factor of 100. The secondary electron emission coefficient for the negative halogen ions relative to I− were measured on CuBe at the kinetic energies 1.0 and 1.5 keV....

  4. Comparison of the Molecular Interaction Volume Model with the Unified Interaction Parameter Formalism in the Fe-Cr-Ni Liquid Alloys at 1873 K

    Institute of Scientific and Technical Information of China (English)

    Dongping TAO

    2006-01-01

    The molecular interaction volume model (MIVM) for a general ternary system was deduced in detail for further clarifying and understanding its general multicomponent expression. Both MIVM and the unified interaction parameterformalism (UIPF) can be used to predict the activities of solutes and solvents in the Fe-Cr-Ni liquid alloys. But the former employs only the infinite dilute activity coefficients, and the later is not applicable without the dilute binary and ternary interaction parameters. MIVM has a certain physical meaning from the viewpoint of statistical thermodynamics, so it is an alternative for the estimation of activity coefficients of the solutes and solvents in a dilute or finite concentration metal solution where the interaction parameters are absent or their accuracies are questionable.

  5. Temperature dependence of pin solar cell parameters with intrinsic layers made of pm-Si:H and low crystalline volume fraction {mu}c-Si:H

    Energy Technology Data Exchange (ETDEWEB)

    Hamadeh, H. [AECS, Physics Department, P.O. Box 6091, Damascus (Syria)

    2010-07-15

    A comparison of the temperature dependence of the IV characteristics parameters of hydrogenated silicon pin solar cells with intrinsic layers made of polymorphous silicon (pm-Si:H) and of {mu}c-Si:H with low crystalline volume fraction has been performed. When using pm-Si:H, higher efficiency and higher filling factors are achieved over a wide temperature range. Diode quality factors of both types of cells show similar temperature dependence. Recombination processes over the whole intrinsic layer dominates the forward current. A change of the cell parameters under illumination is also observed. The transport mechanism of both cells is similar in the temperature range that is important for most applications. Due to its optical and transport properties, pm-Si:H poses a very interesting alternative to {mu}c-Si:H and a-Si:H in the temperature range of normal terrestrial applications. (author)

  6. An analysis of spatially varying turbulent Prandtl number in a flow with local acceleration and deceleration

    Science.gov (United States)

    Jung, Eunbum; Lee, Wook; Kang, Seongwon; Iaccarino, Gianluca

    2015-11-01

    The turbulent Prandtl number (Prt) is an important parameter in turbulent flows used in many engineering models for heat transfer. In the present study, spatial variation of Prt in a wall-bounded turbulent flow is investigated using DNS. We derived a form of Prt applicable to a general flow configuration, using the least-square method in a manner consistent with the turbulent viscosity model in LES. For a flow subject to local acceleration and deceleration induced by the wall geometry, we performed a parametric study for the Reynolds number, Prandtl number and a geometric factor using DNS. A comparison of the data from DNS and RANS with a constant Prt indicates the potential of improved RANS predictions using the present variable Prt subject to the local flow field. Also, it is observed that the local pressure gradient has an important effect on the Prt field. From the flow statistics, a few flow variables showing higher correlations with Prt are identified. An elementary model for Prt is devised, and used for RANS prediction producing a more accurate prediction of the heat transfer rate. Corresponding author

  7. On the mechanism of self-deceleration of the thin oxide film growth

    CERN Document Server

    Mukhambetov, D G

    2002-01-01

    The objective of this work was to investigate the kinetics of the two-phase oxide film growth on the alpha-Fe surface at temperatures of 650-750 K. We experimentally determined that the film thickness (h)-time oxidation (tau) relationship in the range denoted above is a logarithmic function, whereas Cabrera and Mott's theory gives a square law of film growth. In our work, analytical treatment of experimental data was made based on this theory, but we propose that self-deceleration of the film growth is caused not by attenuation of the electric intensity in the film because of an increase of h but by the shielding influence of the space charge of diffusing ions and electrons in that oxide film. With that purpose in view, the Debye shielding distance for plasma substance state in the oxide film was taken into consideration. The logarithmic law of oxide film growth was derived. Estimated calculations of this law's parameters were made that quantitatively correspond with literature data. The results obtained were...

  8. Evaluation of the Acceleration and Deceleration Phase-Rectified Slope to Detect and Improve IUGR Clinical Management

    Directory of Open Access Journals (Sweden)

    Salvatore Tagliaferri

    2015-01-01

    Full Text Available Objective. This study used a new method called Acceleration (or Deceleration Phase-Rectified Slope, APRS (or DPRS to analyze computerized Cardiotocographic (cCTG traces in intrauterine growth restriction (IUGR, in order to calculate acceleration- and deceleration-related fluctuations of the fetal heart rate, and to enhance the prediction of neonatal outcome. Method. Cardiotocograms from a population of 59 healthy and 61 IUGR fetuses from the 30th gestation week matched for gestational age were included. APRS and DPRS analysis was compared to the standard linear and nonlinear cCTG parameters. Statistical analysis was performed through the t-test, ANOVA test, Pearson correlation test and receiver operator characteristic (ROC curves (p<0,05. Results. APRS and DPRS showed high performance to discriminate between Healthy and IUGR fetuses, according to gestational week. A linear correlation with the fetal pH at birth was found in IUGR. The area under the ROC curve was 0.865 for APRS and 0.900 for DPRS before the 34th gestation week. Conclusions. APRS and DPRS could be useful in the identification and management of IUGR fetuses and in the prediction of the neonatal outcome, especially before the 34th week of gestation.

  9. Measurement of ultra-low ion energy of decelerated ion beam using a deflecting electric field

    Energy Technology Data Exchange (ETDEWEB)

    Thopan, P.; Suwannakachorn, D.; Tippawan, U. [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Yu, L.D., E-mail: yuld@thep-center.org [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Thailand Center of Excellence in Physics, Commission on Higher Education, 328 Si Ayutthaya Road, Bangkok 10400 (Thailand)

    2015-12-15

    In investigation on ultra-low-energy ion bombardment effect on DNA, an ion beam deceleration lens was developed for high-quality ultra-low-energy ion beam. Measurement of the ion energy after deceleration was necessary to confirm the ion beam really decelerated as theoretically predicted. In contrast to conventional methods, this work used a simple deflecting electrostatic field after the deceleration lens to bend the ion beam. The beam bending distance depended on the ion energy and was described and simulated. A system for the measurement of the ion beam energy was constructed. It consisted of a pair of parallel electrode plates to generate the deflecting electrical field, a copper rod measurement piece to detect ion beam current, a vernier caliper to mark the beam position, a stepping motor to translate the measurement rod, and a webcam-camera to read the beam bending distance. The entire system was installed after the ion-beam deceleration lens inside the large chamber of the bioengineering vertical ion beam line. Moving the measurement rod across the decelerated ion beam enabled to obtain beam profiles, from which the beam bending distance could be known and the ion beam energy could be calculated. The measurement results were in good agreement with theoretical and simulated results.

  10. Measurement of ultra-low ion energy of decelerated ion beam using a deflecting electric field

    Science.gov (United States)

    Thopan, P.; Suwannakachorn, D.; Tippawan, U.; Yu, L. D.

    2015-12-01

    In investigation on ultra-low-energy ion bombardment effect on DNA, an ion beam deceleration lens was developed for high-quality ultra-low-energy ion beam. Measurement of the ion energy after deceleration was necessary to confirm the ion beam really decelerated as theoretically predicted. In contrast to conventional methods, this work used a simple deflecting electrostatic field after the deceleration lens to bend the ion beam. The beam bending distance depended on the ion energy and was described and simulated. A system for the measurement of the ion beam energy was constructed. It consisted of a pair of parallel electrode plates to generate the deflecting electrical field, a copper rod measurement piece to detect ion beam current, a vernier caliper to mark the beam position, a stepping motor to translate the measurement rod, and a webcam-camera to read the beam bending distance. The entire system was installed after the ion-beam deceleration lens inside the large chamber of the bioengineering vertical ion beam line. Moving the measurement rod across the decelerated ion beam enabled to obtain beam profiles, from which the beam bending distance could be known and the ion beam energy could be calculated. The measurement results were in good agreement with theoretical and simulated results.

  11. Effects of Hypertonic Saline Solution on Clinical Parameters, Serum Electrolytes and Plasma Volume in the Treatment of Haemorrhagic Septicaemia in Buffaloes

    Directory of Open Access Journals (Sweden)

    M. Arif Zafar*, G. Muhammad, Zafar Iqbal1 and M. Riaz2

    2010-04-01

    Full Text Available This study was conducted to determine the efficacy of hypertonic saline solution (HSS along with antibiotic (ceftiofur HCl and non-steroidal anti-inflammatory drug (ketoprofen in the treatment of haemorrhagic septicaemia in buffaloes. For this purpose, 50 buffaloes suffering from haemorrhagic septicaemia were randomly divided in two equal groups A and B. Group A served as control and was treated with ceftiofur HCl (IM and ketoprofen (IV @ 6 and 2 mg/Kg BW, respectively, for five days. Buffaloes of group B were administered with rapid intravenous infusion of hypertonic saline solution (7.5% NaCl @ 4 ml/Kg BW once in combination with ceftiofur HCl and ketoprofen. Animals were monitored for 24 hours after initiation of treatment. Clinical parameters, serum electrolytes, plasma volume and survival index were recorded at different intervals after treatment. Survival rate (80% in group B was significantly higher (P<0.05 than 48% in group A. The heart rate and respiration rate recovered more effectively in the buffaloes administered with treatment protocol B. Plasma volume was 98% which was almost normal within 24 hours after the infusion of hypertonic saline solution to the animals of group B. It was concluded from the study that hypertonic saline solution as an adjunct to antibiotic and a non-steroidal anti-inflammatory drug more efficiently improved respiration and heart rates and effectively restored plasma volume in resuscitating the buffaloes from haemorrhagic septicaemia than the conventional treatment.

  12. Change in volume parameters induced by neoadjuvant chemotherapy provide accurate prediction of overall survival after resection in patients with oesophageal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Tamandl, Dietmar; Fueger, Barbara; Kinsperger, Patrick; Haug, Alexander; Ba-Ssalamah, Ahmed [Medical University of Vienna, Department of Biomedical Imaging and Image-Guided Therapy, Comprehensive Cancer Center GET-Unit, Vienna (Austria); Gore, Richard M. [University of Chicago Pritzker School of Medicine, Department of Radiology, Chicago, IL (United States); Hejna, Michael [Medical University of Vienna, Department of Internal Medicine, Division of Medical Oncology, Comprehensive Cancer Center GET-Unit, Vienna (Austria); Paireder, Matthias; Schoppmann, Sebastian F. [Medical University of Vienna, Department of Surgery, Upper-GI-Service, Comprehensive Cancer Center GET-Unit, Vienna (Austria)

    2016-02-15

    To assess the prognostic value of volumetric parameters measured with CT and PET/CT in patients with neoadjuvant chemotherapy (NACT) and resection for oesophageal cancer (EC). Patients with locally advanced EC, who were treated with NACT and resection, were retrospectively analysed. Data from CT volumetry and {sup 18} F-FDG PET/CT (maximum standardized uptake [SUVmax], metabolic tumour volume [MTV], and total lesion glycolysis [TLG]) were recorded before and after NACT. The impact of volumetric parameter changes induced by NACT (MTV{sub RATIO}, TLG{sub RATIO}, etc.) on overall survival (OS) was assessed using a Cox proportional hazards model. Eighty-four patients were assessed using CT volumetry; of those, 50 also had PET/CT before and after NACT. Low post-treatment CT volume and thickness, MTV, TLG, and SUVmax were all associated with longer OS (p < 0.05), as were CTthickness{sub RATIO}, MTV{sub RATIO}, TLG{sub RATIO}, and SUVmax{sub RATIO} (p < 0.05). In the multivariate analysis, only MTV{sub RATIO} (Hazard ratio, HR 2.52 [95 % Confidence interval, CI 1.33-4.78], p = 0.005), TLG{sub RATIO} (HR 3.89 [95%CI 1.46-10.34], p = 0.006), and surgical margin status (p < 0.05), were independent predictors of OS. MTV{sub RATIO} and TLG{sub RATIO} are independent prognostic factors for survival in patients after NACT and resection for EC. (orig.)

  13. EstimatingPinus palustris tree diameter and stem volume from tree height, crown area and stand-level parameters

    Institute of Scientific and Technical Information of China (English)

    C.A. Gonzalez-Benecke; Salvador A. Gezan; Lisa J. Samuelson; Wendell P. Cropper Jr.; Daniel J. Leduc; Timothy A. Martin

    2014-01-01

    Accurate and efficient estimation of forest growth and live biomass is a critical element in assessing potential responses to forest management and environmental change. The objective of this study was to develop models to predict longleaf pine tree diameter at breast height (dbh) and merchantable stem volume (V) using data obtained from field measurements. We used longleaf pine tree data from 3,376 planted trees on 127 permanent plots located in the U.S. Gulf Coastal Plain region to fit equations to predict dbh and V as functions of tree height (H) and crown area (CA). Prediction of dbh as a function of H improved when CA was added as an additional independent variable. Similarly, predic-tions of V based on H improved when CA was included. Incorporation of additional stand variables such as age, site index, dominant height, and stand density were also evaluated but resulted in only small improve-ments in model performance. For model testing we used data from planted and naturally-regenerated trees located inside and outside the geographic area used for model fitting. Our results suggest that the models are a robust alternative for dbh and V estimations when H and CA are known on planted stands with potential for naturally-regenerated stands, across a wide range of ages. We discuss the importance of these models for use with metrics derived from remote sensing data.

  14. Inclusion of functional information from perfusion SPECT improves predictive value of dose-volume parameters in lung toxicity outcome after radiotherapy for non-small cell lung cancer: A prospective study

    DEFF Research Database (Denmark)

    Farr, Katherina P; Kallehauge, Jesper F; Møller, Ditte S;

    2015-01-01

    BACKGROUND AND PURPOSE: To compare functional and standard dose-volume parameters as predictors of postradiation pulmonary toxicity in lung cancer patients undergoing curative chemo-radiotherapy (RT) studied prospectively. MATERIAL AND METHODS: A total of 58 patients treated with Intensity...... pneumonitis (RP) grade 2-5. RESULTS: Functional mean lung dose (MLD) and lung volumes receiving 5, 10, 20 and 30Gy (V5-V30, respectively) revealed high correlation with corresponding standard parameters (r>0.8). Standard MLD, V20 and V30 were significantly higher in patients with RP (p=0.01). All functional...... Modulated RT (60-66Gy) were analysed. Standard dose-volume parameters were extracted from treatment planning computed tomography (CT) scans. Corresponding functional dose-volume parameters were calculated from perfusion single-photon emission computed tomography (SPECT). Primary end-point was radiation...

  15. Impact of image denoising on image quality, quantitative parameters and sensitivity of ultra-low-dose volume perfusion CT imaging

    Energy Technology Data Exchange (ETDEWEB)

    Othman, Ahmed E. [RWTH Aachen University, Department of Diagnostic and Interventional Neuroradiology, Aachen (Germany); Eberhard Karls University Tuebingen, University Hospital Tuebingen, Department for Diagnostic and Interventional Radiology, Tuebingen (Germany); Brockmann, Carolin; Afat, Saif; Pjontek, Rastislav; Nikoubashman, Omid; Brockmann, Marc A.; Wiesmann, Martin [RWTH Aachen University, Department of Diagnostic and Interventional Neuroradiology, Aachen (Germany); Yang, Zepa; Kim, Changwon [Seoul National University, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Suwon (Korea, Republic of); Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Nikolaou, Konstantin [Eberhard Karls University Tuebingen, University Hospital Tuebingen, Department for Diagnostic and Interventional Radiology, Tuebingen (Germany); Kim, Jong Hyo [Seoul National University, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Suwon (Korea, Republic of); Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Advanced Institute of Convergence Technology, Center for Medical-IT Convergence Technology Research, Suwon (Korea, Republic of); Seoul National University Hospital, Department of Radiology, Seoul (Korea, Republic of)

    2016-01-15

    To examine the impact of denoising on ultra-low-dose volume perfusion CT (ULD-VPCT) imaging in acute stroke. Simulated ULD-VPCT data sets at 20 % dose rate were generated from perfusion data sets of 20 patients with suspected ischemic stroke acquired at 80 kVp/180 mAs. Four data sets were generated from each ULD-VPCT data set: not-denoised (ND); denoised using spatiotemporal filter (D1); denoised using quanta-stream diffusion technique (D2); combination of both methods (D1 + D2). Signal-to-noise ratio (SNR) was measured in the resulting 100 data sets. Image quality, presence/absence of ischemic lesions, CBV and CBF scores according to a modified ASPECTS score were assessed by two blinded readers. SNR and qualitative scores were highest for D1 + D2 and lowest for ND (all p ≤ 0.001). In 25 % of the patients, ND maps were not assessable and therefore excluded from further analyses. Compared to original data sets, in D2 and D1 + D2, readers correctly identified all patients with ischemic lesions (sensitivity 1.0, kappa 1.0). Lesion size was most accurately estimated for D1 + D2 with a sensitivity of 1.0 (CBV) and 0.94 (CBF) and an inter-rater agreement of 1.0 and 0.92, respectively. An appropriate combination of denoising techniques applied in ULD-VPCT produces diagnostically sufficient perfusion maps at substantially reduced dose rates as low as 20 % of the normal scan. (orig.)

  16. Uncertainty quantification of seabed parameters for large data volumes along survey tracks with a tempered particle filter

    Science.gov (United States)

    Dettmer, J.; Quijano, J. E.; Dosso, S. E.; Holland, C. W.; Mandolesi, E.

    2016-12-01

    Geophysical seabed properties are important for the detection and classification of unexploded ordnance. However, current surveying methods such as vertical seismic profiling, coring, or inversion are of limited use when surveying large areas with high spatial sampling density. We consider surveys based on a source and receiver array towed by an autonomous vehicle which produce large volumes of seabed reflectivity data that contain unprecedented and detailed seabed information. The data are analyzed with a particle filter, which requires efficient reflection-coefficient computation, efficient inversion algorithms and efficient use of computer resources. The filter quantifies information content of multiple sequential data sets by considering results from previous data along the survey track to inform the importance sampling at the current point. Challenges arise from environmental changes along the track where the number of sediment layers and their properties change. This is addressed by a trans-dimensional model in the filter which allows layering complexity to change along a track. Efficiency is improved by likelihood tempering of various particle subsets and including exchange moves (parallel tempering). The filter is implemented on a hybrid computer that combines central processing units (CPUs) and graphics processing units (GPUs) to exploit three levels of parallelism: (1) fine-grained parallel computation of spherical reflection coefficients with a GPU implementation of Levin integration; (2) updating particles by concurrent CPU processes which exchange information using automatic load balancing (coarse grained parallelism); (3) overlapping CPU-GPU communication (a major bottleneck) with GPU computation by staggering CPU access to the multiple GPUs. The algorithm is applied to spherical reflection coefficients for data sets along a 14-km track on the Malta Plateau, Mediterranean Sea. We demonstrate substantial efficiency gains over previous methods. [This

  17. Impact and intrusion experiments on the deceleration of low-velocity impactors by small-body regolith

    Science.gov (United States)

    Nakamura, Akiko M.; Setoh, Masato; Wada, Koji; Yamashita, Yasuyuki; Sangen, Kazuyoshi

    2013-03-01

    Previous laboratory impact experiments into sand and glass beads have enriched our understanding of the cratering process on granular media common on asteroids and planetary regolith. However, less attention has been paid to the fate of the projectile, such as its penetration depth in the granular medium, although this may be important for the regolith mixing process. We conducted laboratory experiments on the deceleration of projectiles with low impact velocities to understand the re-accumulation process of ejecta on small asteroids. Glass beads were used as a model of a granular target. Impact experiments using 6-mm plastic projectiles with velocities of ∼70 m s-1 were performed on the Earth’s surface and under microgravity. Measurements of the resistance force of the glass beads against slow intrusion and penetration were also performed. In the impact experiments, the projectiles were decelerated mainly as a result of drag proportional to the square of the velocity. The drag coefficient was 0.9-1.5. Additionally, we found a possible term proportional to the projectile velocity corresponding to the viscous drag with a viscosity up to 2 Pa s. These forces are consistent with numerical simulations that we carried out. The slow intrusion and penetration measurements showed that the velocity-independent resistance force per unit area on a projectile is roughly 20 times larger than the lithostatic pressure. The penetration depth of re-accumulated ejecta was examined based on the drag parameters obtained in this study. A simple configuration was used to visualize the dependence of penetration depth on the drag parameters. The penetration depth was more sensitive to the drag parameters in the case of small particles impacting a relatively small model asteroid.

  18. Prognostic Value of Volume-Based {sup 18}F-Fluorodeoxyglucose PET/CT Parameters in Patients with Clinically Node-Negative Oral Tongue Squamous Cell Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Su Jin [Dept. of Nuclear Medicine, Ajou University School of Medicine, Suwon (Korea, Republic of); Choi, Joon Young; Lee, Hwan Joo; Hyun, Seung Hyup; Moon, Seung Hwan; Kim, Byung Tae [Dept. of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Baek, Chung Hwan; Son, Young Ik [Dept. of Otorhinolaryngology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2012-11-15

    To evaluate the prognostic value of volume-based metabolic parameters measured with {sup 18}F-fluorodeoxyglucose ({sup 18}F-FDG) positron emission tomography (PET) in patients with clinically node-negative (cN0) oral tongue squamous cell carcinoma (OTSCC) as compared with other prognostic factors. In this study, we included a total of 57 patients who had been diagnosed with cN0 tongue cancer by radiologic, ({sup 18}F-FDG PET/CT, and physical examinations. The maximum standardized uptake value (SUVmax), average SUV (SUVavg), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for primary tumors were measured with ({sup 18}F-FDG PET. The prognostic significances of these parameters and other clinical variables were assessed by Cox proportional hazards regression analysis. In the univariate analysis, pathological node (pN) stage, American Joint Committee on Cancer (AJCC) stage, SUVmax, SUVavg, MTV, and TLG were significant predictors for survival. On a multivariate analysis, pN stage (hazard ratio = 10.555, p = 0.049), AJCC stage (hazard ratio = 13.220, p = 0.045), and MTV (hazard ratio = 2.698, p 0.033) were significant prognostic factors in cN0 OTSCC patients. The patients with MTV {>=} 7.78 cm{sup 3} showed a worse prognosis than those with MTV < 7.78 cm{sup 3} (p = 0.037). The MTV of primary tumor as a volumetric parameter of ({sup 18}F-FDG PET, in addition to pN stage and AJCC stage, is an independent prognostic factor for survival in cN0 OTSCC.

  19. Treatment of Locally Advanced Vaginal Cancer With Radiochemotherapy and Magnetic Resonance Image-Guided Adaptive Brachytherapy: Dose-Volume Parameters and First Clinical Results

    Energy Technology Data Exchange (ETDEWEB)

    Dimopoulos, Johannes C.A. [Department of Radiation Oncology, Metropolitan Hospital, Athens (Greece); Schmid, Maximilian P., E-mail: maximilian.schmid@akhwien.at [Department of Radiotherapy, Medical University of Vienna, Vienna (Austria); Fidarova, Elena; Berger, Daniel; Kirisits, Christian; Poetter, Richard [Department of Radiotherapy, Medical University of Vienna, Vienna (Austria)

    2012-04-01

    Purpose: To investigate the clinical feasibility of magnetic resonance image-guided adaptive brachytherapy (IGABT) for patients with locally advanced vaginal cancer and to report treatment outcomes. Methods and Materials: Thirteen patients with vaginal cancer were treated with external beam radiotherapy (45-50.4 Gy) plus IGABT with or without chemotherapy. Distribution of International Federation of Gynecology and Obstetrics stages among patients were as follows: 4 patients had Stage II cancer, 5 patients had Stage III cancer, and 4 patients had Stage IV cancer. The concept of IGABT as developed for cervix cancer was transferred and adapted for vaginal cancer, with corresponding treatment planning and reporting. Doses were converted to the equivalent dose in 2 Gy, applying the linear quadratic model ({alpha}/{beta} = 10 Gy for tumor; {alpha}/{beta} = 3 for organs at risk). Endpoints studied were gross tumor volume (GTV), dose-volume parameters for high-risk clinical target volume (HRCTV), and organs at risk, local control (LC), adverse side effects, and survival. Results: The mean GTV ({+-} 1 standard deviation) at diagnosis was 45.3 ({+-}30) cm{sup 3}, and the mean GTV at brachytherapy was 10 ({+-}14) cm{sup 3}. The mean D90 for the HRCTV was 86 ({+-}13) Gy. The mean D2cc for bladder, urethra, rectum, and sigmoid colon were 80 ({+-}20) Gy, 76 ({+-}16) Gy, 70 ({+-}9) Gy, and 60 ({+-}9) Gy, respectively. After a median follow-up of 43 months (range, 19-87 months), one local recurrence and two distant metastases cases were observed. Actuarial LC and overall survival rates at 3 years were 92% and 85%. One patient with Stage IVA and 1 patient with Stage III disease experienced fistulas (one vesicovaginal, one rectovaginal), and 1 patient developed periurethral necrosis. Conclusions: The concept of IGABT, originally developed for treating cervix cancer, appears to be applicable to vaginal cancer treatment with only minor adaptations. Dose-volume parameters for HRCTV and

  20. Stereoscopic camera and viewing systems with undistorted depth presentation and reduced or eliminated erroneous acceleration and deceleration perceptions, or with perceptions produced or enhanced for special effects

    Science.gov (United States)

    Diner, Daniel B. (Inventor)

    1991-01-01

    Methods for providing stereoscopic image presentation and stereoscopic configurations using stereoscopic viewing systems having converged or parallel cameras may be set up to reduce or eliminate erroneously perceived accelerations and decelerations by proper selection of parameters, such as an image magnification factor, q, and intercamera distance, 2w. For converged cameras, q is selected to be equal to Ve - qwl = 0, where V is the camera distance, e is half the interocular distance of an observer, w is half the intercamera distance, and l is the actual distance from the first nodal point of each camera to the convergence point, and for parallel cameras, q is selected to be equal to e/w. While converged cameras cannot be set up to provide fully undistorted three-dimensional views, they can be set up to provide a linear relationship between real and apparent depth and thus minimize erroneously perceived accelerations and decelerations for three sagittal planes, x = -w, x = 0, and x = +w which are indicated to the observer. Parallel cameras can be set up to provide fully undistorted three-dimensional views by controlling the location of the observer and by magnification and shifting of left and right images. In addition, the teachings of this disclosure can be used to provide methods of stereoscopic image presentation and stereoscopic camera configurations to produce a nonlinear relation between perceived and real depth, and erroneously produce or enhance perceived accelerations and decelerations in order to provide special effects for entertainment, training, or educational purposes.

  1. Laser-assisted Stark deceleration of polar diatomic molecules in the Χ1Σ state

    Science.gov (United States)

    Huang, Yunxia; Xu, Shuwu; Yang, Xiaohua

    2016-07-01

    The traditional Stark deceleration method is difficult to apply in chemically stable polar diatomic molecules in their ground (Χ1Σ) state because the Χ1Σ state normally experiences little Stark shift and the rovibronic ground level is mostly high-field-seeking. To solve this problem, we propose a laser-assisted Stark deceleration scheme to decelerate such molecules in the present paper. Our results show that, owing to the transverse bunching effect of the applied red-detuning laser beam, the molecules of the high-field-seeking level |J = 0, M = 0> in the Χ1Σ state can be effectively decelerated. Furthermore, the present scheme is more effective because the interaction between the molecules and the combined fields can produce the pseudo-first-order Stark effect, and thus increase the depth of the effective potential. Compared to those molecules in the low-field-seeking state |J = 1, MΩ = -1> in the usual electrostatic Stark deceleration, a higher molecular density and lower velocity can be achieved under an equivalent initial phase angle.

  2. Correlation between deceleration capacity of rate and myocardial injury degree in children with viral myocarditis

    Institute of Scientific and Technical Information of China (English)

    Jing-Yang Zhang; Hui Wu

    2016-01-01

    Objective:To find the correlation between deceleration capacity of rate and myocardial injury degree in children with viral myocarditis.Methods:A total of 90 children with viral myocarditis and 86 healthy children were selected as the research subjects, differences in rate deceleration capacity of rate and myocardial damage degree indexes were compared between two groups of children, and the correlation between deceleration capacity of rate and myocardial injury degree was further analyzed.Results:Mean DC level as well as heart rate variability indexes SDNN, SDANN, RMSSD, LF and HF levels of observation group was lower than those of control group; serum myocardial enzyme spectrum indexes CK, CK-MB, cTnⅠ, LDH, AST and ALT content were higher than those of control group; serum apoptosis indexes GRBS, sFasL, Bax and caspase-3 content were higher than those of control group while Bcl-2 content was lower than that of control group; heart rate indexes MSV1, MSV2, MSV3, PFVe and PFVa levels were lower than those of control group. Deceleration capacity of rate in children with viral myocarditis was directly correlated with myocardial injury-related indexes such as heart rate variability, myocardial enzyme spectrum, myocardial apoptosis and heart rate.Conclusions: The change of deceleration capacity of rate in children with viral myocarditis is directly correlated with myocardial injury, and can be used as a reliable medium for disease severity judgment and clinical treatment guidance.

  3. The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism

    Directory of Open Access Journals (Sweden)

    Dilek Torun

    2016-01-01

    Full Text Available The aim of this study was to investigate the effects of cinacalcet therapy on anemia parameters, bone mineral metabolism, left ventricular mass index (LVMI and parathyroid gland volume in hemodialysis (HD patients with secondary hyperparathyroidism. Twenty-five HD patients (M/F: 11/14, mean age: 45.2 ± 17.9 years, mean HD duration: 96.4 ± 32.7 months were included in this prospective pilot study. The indication to start calcimimetic therapy was persistent serum levels of parathyroid hormone (PTH >1000 pg/mL, refractory to intravenous (i.v. vitamin D and phosphate-binding therapy. The initial and one-year results of adjusted serum calcium (Ca +2 , phosphate (P, Ca × P product, PTH, hemoglobin (Hb and ferritin levels, transferrin saturation index (TSAT, median weekly erythropoietin (EPO dose, LVMI, and parathyroid volume by parathyroid ultrasonography were determined. There were no differences between pre- and post-treatment levels of serum Ca +2 (P = 0.853, P (P = 0.447, Ca × P product (P = 0.587, PTH (P = 0.273, ferritin (P = 0.153 and TSAT (P = 0.104. After 1 year of calcimimetic therapy, the Hb levels were significantly higher than the initial levels (P = 0.048. The weekly dose of EPO decreased with no statistical significance. The dose of cinacalcet was increased from 32.4 ± 12.0 to 60.0 ± 24.4 mg/day (P = 0.01. There were no differences between the pre- and post-treatment results regarding weekly vitamin D dose, parenteral iron dose, LVMI and parathyroid volume. The results of our study suggest that cinacalcet therapy might have an additional benefit in the control anemia in HD patients.

  4. The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism.

    Science.gov (United States)

    Torun, Dilek; Yildiz, Ismail; Micozkadioglu, Hasan; Nursal, Gul Nihal; Yigit, Fatma; Ozelsancak, Ruya

    2016-01-01

    The aim of this study was to investigate the effects of cinacalcet therapy on anemia parameters, bone mineral metabolism, left ventricular mass index (LVMI) and parathyroid gland volume in hemodialysis (HD) patients with secondary hyperparathyroidism. Twenty-five HD patients (M/F: 11/14, mean age: 45.2±17.9 years, mean HD duration: 96.4±32.7 months) were included in this prospective pilot study. The indication to start calcimimetic therapy was persistent serum levels of parathyroid hormone (PTH)>1000 pg/mL, refractory to intravenous (i.v.) vitamin D and phosphate-binding therapy. The initial and one-year results of adjusted serum calcium (Ca+2), phosphate (P), Ca×P product, PTH, hemoglobin (Hb) and ferritin levels, transferrin saturation index (TSAT), median weekly erythropoietin (EPO) dose, LVMI, and parathyroid volume by parathyroid ultrasonography were determined. There were no differences between pre- and post-treatment levels of serum Ca+2 (P=0.853), P (P=0.447), Ca×P product (P=0.587), PTH (P=0.273), ferritin (P=0.153) and TSAT (P=0.104). After 1 year of calcimimetic therapy, the Hb levels were significantly higher than the initial levels (P=0.048). The weekly dose of EPO decreased with no statistical significance. The dose of cinacalcet was increased from 32.4±12.0 to 60.0±24.4 mg/day (P=0.01). There were no differences between the pre- and post-treatment results regarding weekly vitamin D dose, parenteral iron dose, LVMI and parathyroid volume. The results of our study suggest that cinacalcet therapy might have an additional benefit in the control anemia in HD patients.

  5. Could mean platelet volume among complete blood count parameters be a surrogate marker of metabolic syndrome in pre-pubertal children?

    Science.gov (United States)

    Aypak, Cenk; Türedi, Ozlem; Bircan, Mustafa A; Yüce, Adnan

    2014-01-01

    Interest in childhood metabolic syndrome (MetS) has increased substantially due to the increasing prevalence of childhood obesity on a global scale. Early recognition of MetS is critical in order to delay the development of cardiovascular disease (CVD). In this study, we evaluated the relationship between complete blood count (CBC) parameters and MetS among pre-pubertal children which may provide evidence in support of using low cost, readily available clinical haematological parameters for the detection of MetS. A retrospective analysis was carried out on 330 (125 lean vs. 205 overweight) Turkish pre-pubertal children who attend to a paediatric outpatient clinic. Age, gender, puberty, body mass index, CBC parameters, cardiometabolic risk factors including lipid profiles, high sensitive serum reactive protein (hsCRP) and insulin resistance index calculated by homeostasis model assessment (HOMA-IR) were evaluated and compared among lean, overweight children and children with MetS. The mean age of the study population was 7.4 ± 1.9 years. In both gender, the mean values of mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) were significantly lower and red blood cell (RBC), platelet (PLT) counts were significantly higher in overweight children. Overall, 8.4% (n = 28) of patients met the criteria of MetS. Children with MetS had higher levels of PLT and lower levels of mean platelet volume (MPV). Of all the haematological parameters analysed, PLT was positively, whereas MPV was negatively correlated with MetS in girls. In addition, MPV was inversely correlated with fasting blood glucose, HOMA-IR, low density lipoprotein-cholesterol (LDL-C) and low density lipoprotein-cholesterol/high density lipoprotein-cholesterol (LDL-C/HDL-C) ratio in girls after adjusting for confounding factors. The risk analyses of MetS in terms of MPV quartiles showed that the adjusted OR (95% CI) for the lowest vs. the

  6. Assessment of histological response of paediatric bone sarcomas using FDG PET in comparison to morphological volume measurement and standardized MRI parameters

    Energy Technology Data Exchange (ETDEWEB)

    Denecke, Timm; Misch, Daniel; Steffen, Ingo G.; Plotkin, Michail; Stoever, Brigitte [Charite - Universitaetsmedizin Berlin, Klinik fuer Strahlenheilkunde, Campus Virchow-Klinikum, Berlin (Germany); Hundsdoerfer, Patrick; Henze, Guenter [Charite - Universitaetsmedizin Berlin, Klinik fuer Paediatrie m.S. Onkologie und Haematologie, Otto-Heubner-Zentrum, Campus Virchow-Klinikum, Berlin (Germany); Schoenberger, Stefan [Universitaetsklinikum der Heinrich-Heine-Universitaet Duesseldorf, Klinik fuer Kinder-Onkologie, -Haematologie und -Immunologie, Duesseldorf (Germany); Furth, Christian; Ruf, Juri [Otto-von-Guericke-Universitaet Magdeburg, Klinik fuer Radiologie und Nuklearmedizin, Universitaetsklinikum Magdeburg A.oe.R., Magdeburg (Germany); Hautzel, Hubertus [Universitaetsklinikum der Heinrich Heine Universitaet Duesseldorf, Nuklearmedizinische Klinik, Duesseldorf (Germany); Kluge, Regine [Universitaetsklinikum Leipzig A.oe.R., Klinik und Poliklinik fuer Nuklearmedizin, Leipzig (Germany); Bierbach, Uta [Universitaetsklinikum Leipzig A.oe.R., Abteilung fuer Kinder-Haematologie, -Onkologie und -Haemostaseologie, Leipzig (Germany); Otto, Sylke [Universitaetsklinikum Greifswald, Institut fuer Diagnostische Radiologie und Neuroradiologie, Greifswald (Germany); Beck, James F. [Universitaetsklinikum Greifswald, Abteilung fuer Paediatrische Haematologie und Onkologie, Greifswald (Germany); Franzius, Christiane [MR- und PET/CT-Zentrum, Bremen-Mitte (Germany); Universitaetsklinikum Muenster, Klinik und Poliklinik fuer Nuklearmedizin, Muenster (Germany); Amthauer, Holger [Charite - Universitaetsmedizin Berlin, Klinik fuer Strahlenheilkunde, Campus Virchow-Klinikum, Berlin (Germany); Otto-von-Guericke-Universitaet Magdeburg, Klinik fuer Radiologie und Nuklearmedizin, Universitaetsklinikum Magdeburg A.oe.R., Magdeburg (Germany)

    2010-10-15

    The objective of this study was to evaluate positron emission tomography (PET) using {sup 18}F-fluoro-2-deoxy-D-glucose (FDG) in comparison to volumetry and standardized magnetic resonance imaging (MRI) parameters for the assessment of histological response in paediatric bone sarcoma patients. FDG PET and local MRI were performed in 27 paediatric sarcoma patients [Ewing sarcoma family of tumours (EWS), n = 16; osteosarcoma (OS), n = 11] prior to and after neoadjuvant chemotherapy before local tumour resection. Several parameters for assessment of response of the primary tumour to therapy by FDG PET and MRI were evaluated and compared with histopathological regression of the resected tumour as defined by Salzer-Kuntschik. FDG PET significantly discriminated responders from non-responders using the standardized uptake value (SUV) reduction and the absolute post-therapeutic SUV (SUV2) in the entire patient population ({nabla}SUV, p = 0.005; SUV2, p = 0.011) as well as in the subgroup of OS patients ({nabla}SUV, p = 0.009; SUV2, p = 0.028), but not in the EWS subgroup. The volume reduction measured by MRI/CT did not significantly discriminate responders from non-responders either in the entire population (p = 0.170) or in both subgroups (EWS, p = 0.950; OS, p = 1.000). The other MRI parameters alone or in combination were unreliable and did not improve the results. Comparing diagnostic parameters of FDG PET and local MRI, metabolic imaging showed high superiority in the subgroup of OS patients, while similar results were observed in the population of EWS. FDG PET appears to be a useful tool for non-invasive response assessment in the group of OS patients and is superior to MRI. In EWS patients, however, neither FDG PET nor volumetry or standardized MRI criteria enabled a reliable response assessment to be made after neoadjuvant treatment. (orig.)

  7. Mean nuclear volume

    DEFF Research Database (Denmark)

    Mogensen, O.; Sørensen, Flemming Brandt; Bichel, P.

    1999-01-01

    We evaluated the following nine parameters with respect to their prognostic value in females with endometrial cancer: four stereologic parameters [mean nuclear volume (MNV), nuclear volume fraction, nuclear index and mitotic index], the immunohistochemical expression of cancer antigen (CA125...

  8. Loci of a Rotor Consisting of Disc and Shaft with the Moment of Inertia During Deceleration Through a Critical Speed

    OpenAIRE

    OZAWA,Yasumi

    2007-01-01

    A theoretical study of the vibration during deceleration through a critical speed with consideration of the moment of inertia has been made in this study. Loci of a rotor consisting of a disc and shaft with the moment of inertia during deceleration through the first critical speed is calculated numerically taking into account the moment of inertia, so that the following conclusion is obtained : The rotor can pass the critical speed during deceleration in no dumping system in case of finite mo...

  9. Risk Factors for Neovascular Glaucoma After Proton Beam Therapy of Uveal Melanoma: A Detailed Analysis of Tumor and Dose–Volume Parameters

    Energy Technology Data Exchange (ETDEWEB)

    Mishra, Kavita K., E-mail: kmishra@radonc.ucsf.edu [Department of Radiation Oncology, University of California, San Francisco, San Francisco, California (United States); Daftari, Inder K.; Weinberg, Vivian [Department of Radiation Oncology, University of California, San Francisco, San Francisco, California (United States); Cole, Tia [The Tumori Foundation, San Francisco, California (United States); Quivey, Jeanne M.; Castro, Joseph R.; Phillips, Theodore L. [Department of Radiation Oncology, University of California, San Francisco, San Francisco, California (United States); Char, Devron H. [The Tumori Foundation, San Francisco, California (United States)

    2013-10-01

    Purpose: To determine neovascular glaucoma (NVG) incidence and identify contributing tumor and dosing factors in uveal melanoma patients treated with proton beam radiation therapy (PBRT). Methods and Materials: A total of 704 PBRT patients treated by a single surgeon (DHC) for uveal melanoma (1996-2010) were reviewed for NVG in our prospectively maintained database. All patients received 56 GyE in 4 fractions. Median follow-up was 58.3 months. Analyses included the Kaplan-Meier method to estimate NVG distributions, univariate log–rank tests, and Cox's proportional hazards multivariate analysis using likelihood ratio tests to identify independent risk factors of NVG among patient, tumor, and dose–volume histogram parameters. Results: The 5-year PBRT NVG rate was 12.7% (95% confidence interval [CI] 10.2%-15.9%). The 5-year rate of enucleation due to NVG was 4.9% (95% CI 3.4%-7.2%). Univariately, the NVG rate increased significantly with larger tumor diameter (P<.0001), greater height (P<.0001), higher T stage (P<.0001), and closer proximity to the disc (P=.002). Dose–volume histogram analysis revealed that if >30% of the lens or ciliary body received ≥50% dose (≥28 GyE), there was a higher probability of NVG (P<.0001 for both). Furthermore, if 100% of the disc or macula received ≥28 GyE, the NVG rate was higher (P<.0001 and P=.03, respectively). If both anterior and posterior doses were above specified cut points, NVG risk was highest (P<.0001). Multivariate analysis confirmed significant independent risk factors to include tumor height (P<.0001), age (P<.0001), %disc treated to ≥50% Dose (<100% vs 100%) (P=.0007), larger tumor diameter (P=.01), %lens treated to ≥90% Dose (0 vs >0%-30% vs >30%) (P=.01), and optic nerve length treated to ≥90% Dose (≤1 mm vs >1 mm) (P=.02). Conclusions: Our current PBRT patients experience a low rate of NVG and resultant enucleation compared with historical data. The present analysis shows that tumor height

  10. A switched ring Stark decelerator for both light and heavy polar molecules

    Science.gov (United States)

    Hou, Shunyong; Wang, Qin; Deng, Lianzhong; Yin, Jianping

    2016-03-01

    There is increasing interest in cold heavy polar molecular species for their applications in fundamental physics, such as the tests of the electron’s electric dipole moment. Here we propose a switched ring Stark decelerator suitable for slowing both light and heavy polar molecules. Two typical polar molecular species, ND3 and 205TlF, are employed to test the feasibility of our scheme with the help of trajectory calculation. Our proposed scheme is found to share many advantages with the state-of-the-art traveling wave decelerator, yet with relatively simple electronics and flexible operation modes. Sub-millikelvin molecular samples can be conveniently obtained in our decelerator using a combined operation mode. These monochromatic beams are ideal starting points for precise studies of molecular collision, cold chemistry and high-resolution spectroscopy.

  11. Simultaneous, Unsteady PIV and Photogrammetry Measurements of a Tension-Cone Decelerator in Subsonic Flow

    Science.gov (United States)

    Schairer, Edward T.; Heineck, James T.; Walker, Louise Ann; Kushner, Laura Kathryn; Zilliac, Gregory

    2010-01-01

    This paper describes simultaneous, synchronized, high-frequency measurements of both unsteady flow in the wake of a tension-cone decelerator in subsonic flow (by PIV) and the unsteady shape of the decelerator (by photogrammetry). The purpose of these measurements was to develop the test techniques necessary to validate numerical methods for computing fluid-structure interactions of flexible decelerators. A critical need for this effort is to map fabric surfaces that have buckled or wrinkled so that code developers can accurately represent them. This paper describes a new photogrammetric technique that performs this measurement. The work was done in support of the Entry, Descent, and Landing discipline within the Supersonics Project of NASA s Fundamental Aeronautics Program.

  12. Continuous all-optical deceleration and single-photon cooling of molecular beams

    CERN Document Server

    Jayich, A M; Hummon, M T; Porto, J V; Campbell, W C

    2013-01-01

    Ultracold molecular gases are promising as an avenue to rich many-body physics, quantum chemistry, quantum information, and precision measurements. This richness, which flows from the complex internal structure of molecules, makes the creation of ultracold molecular gases using traditional methods (laser plus evaporative cooling) a challenge, in particular due to the spontaneous decay of molecules into dark states. We propose a way to circumvent this key bottleneck using an all-optical method for decelerating molecules using stimulated absorption and emission with a single ultrafast laser. We further describe single-photon cooling of the decelerating molecules that exploits their high dark state pumping rates, turning the principal obstacle to molecular laser cooling into an advantage. Cooling and deceleration may be applied simultaneously and continuously to load molecules into a trap. We discuss implementation details including multi-level numerical simulations of strontium monohydride (SrH). These techniqu...

  13. Heart rate deceleration after exercise predicts patients most likely to respond to cardiac resynchronisation therapy.

    Science.gov (United States)

    Thomas, D E; Exton, S A; Yousef, Z R

    2010-09-01

    This study examines the relationship between heart rate recovery following exercise and subsequent response to cardiac resynchronisation therapy (CRT). Blunted heart rate recovery is an adverse prognostic marker in heart failure and has been shown to correlate with disease severity. 37 patients receiving biventricular pacemakers for conventional indications underwent functional assessments; cardiopulmonary exercise test, 6-min walk test and quality-of-life assessment, together with echo analyses, before and at 3 months following implant. Heart rate deceleration (HRD) gradients were calculated at 30-, 60-, 90- and 120-s intervals following cessation of the baseline exercise test and compared with subsequent markers of response to CRT. Functional response was defined as > or =20% improvement in any two of the three functional assessments, and echo response defined as > or =5% increase in ejection fraction. Functional responders demonstrated steeper HRD gradients than non-responders at 30, 60 and 90 s. Echo responders also demonstrated steeper HRD at 30 and 60 s from the cessation of exercise. Receiver-operating curve analysis demonstrates area under the curve of 0.87 and 0.82, respectively, for HRD30 to predict functional and echo response to CRT. A cut-off value of 3 for HRD30, equating to a 5% reduction in HR between peak exercise and 30 s into recovery, demonstrates the optimal sensitivity/specificity profile to perform this function. HRD following exercise correlates with functional and echocardiographic response to CRT. Application of this parameter in addition to standard criteria may provide valuable supplementary information in the evaluation of prospective CRT candidates.

  14. Computer simulations for a deceleration and radio frequency quadrupole instrument for accelerator ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Eliades, J.A., E-mail: j.eliades@alum.utoronto.ca; Kim, J.K.; Song, J.H.; Yu, B.Y.

    2015-10-15

    Radio-frequency quadrupole (RFQ) technology incorporated into the low energy ion beam line of an accelerator system can greatly broaden the range of applications and facilitate unique experimental capabilities. However, ten’s of keV kinetic energy negative ion beams with large emittances and energy spreads must first be decelerated down to <100 eV for ion–gas interactions, placing special demands on the deceleration optics and RFQ design. A system with large analyte transmission in the presence of gas has so far proven challenging. Presented are computer simulations using SIMION 8.1 for an ion deceleration and RFQ ion guide instrument design. Code included user-defined gas pressure gradients and threshold energies for ion–gas collisional losses. Results suggest a 3 mm diameter, 35 keV {sup 36}Cl{sup −} ion beam with 8 eV full-width half maximum Gaussian energy spread and 35 mrad angular divergence can be efficiently decelerated and then cooled in He gas, with a maximum pressure of 7 mTorr, to 2 eV within 450 mm in the RFQs. Vacuum transmissions were 100%. Ion energy distributions at initial RFQ capture are shown to be much larger than the average value expected from the deceleration potential and this appears to be a general result arising from kinetic energy gain in the RFQ field. In these simulations, a potential for deceleration to 25 eV resulted in a 30 eV average energy distribution with a small fraction of ions >70 eV.

  15. Changes in Acceleration and Deceleration Capacity Throughout Professional Soccer Match-Play.

    Science.gov (United States)

    Russell, Mark; Sparkes, William; Northeast, Jonny; Cook, Christian J; Love, Tom D; Bracken, Richard M; Kilduff, Liam P

    2016-10-01

    Russell, M, Sparkes, W, Northeast, J, Cook, CJ, Love, TD, Bracken, RM, and Kilduff, LP. Changes in acceleration and deceleration capacity throughout professional soccer match-play. J Strength Cond Res 30(10): 2839-2844, 2016-As the acceleration and deceleration demands of soccer are currently not well understood, this study aimed to profile markers of acceleration and deceleration capacity during professional soccer match-play. This within-player observational study required reserve team players from a Premier League club to wear 10-Hz Global Positioning System units throughout competitive matches played in the 2013-14 competitive season. Data are presented for players who completed 4 or more games during the season (n = 11), and variables are presented according to six 15-minute intervals (I1-6: 00:00-14:59 minutes, 15:00-29:59 minutes, 30:00-44:59 minutes, 45:00-59:59 minutes, 60:00-74:59 minutes, and 75:00-89:59 minutes, respectively). During I6, the distance covered (total, per minute, and at high intensity), number of sprints, accelerations (total and high intensity), decelerations (total and high intensity), and impacts were reduced compared with I1 (all p ≤ 0.05). The number of high-intensity impacts remained unchanged throughout match-play (p > 0.05). These findings indicate that high-intensity actions and markers of acceleration and deceleration capacity are reduced in the last 15 minutes of the normal duration of match-play. Such information can be used to increase the specificity of training programs designed for soccer players while also giving further insight in to the effects of 90 minutes of soccer-specific exercise. Interventions that seek to maintain the acceleration and deceleration capacity of players throughout the full duration of a soccer match warrant investigation.

  16. DebrisInterMixing-2.3: a finite volume solver for three-dimensional debris-flow simulations with two calibration parameters - Part 1: Model description

    Science.gov (United States)

    von Boetticher, Albrecht; Turowski, Jens M.; McArdell, Brian W.; Rickenmann, Dieter; Kirchner, James W.

    2016-08-01

    Here, we present a three-dimensional fluid dynamic solver that simulates debris flows as a mixture of two fluids (a Coulomb viscoplastic model of the gravel mixed with a Herschel-Bulkley representation of the fine material suspension) in combination with an additional unmixed phase representing the air and the free surface. We link all rheological parameters to the material composition, i.e., to water content, clay content, and mineral composition, content of sand and gravel, and the gravel's friction angle; the user must specify only two free model parameters. The volume-of-fluid (VoF) approach is used to combine the mixed phase and the air phase into a single cell-averaged Navier-Stokes equation for incompressible flow, based on code adapted from standard solvers of the open-source CFD software OpenFOAM. This effectively single-phase mixture VoF method saves computational costs compared to the more sophisticated drag-force-based multiphase models. Thus, complex three-dimensional flow structures can be simulated while accounting for the pressure- and shear-rate-dependent rheology.

  17. New Method for Confirming the Desired Safety Headway Distance and Desired Deceleration in ACC System

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jing-bo; LIU Zhao-du; SONG Ming; QI Zhi-quan

    2005-01-01

    A new method of confirming the desired safety headway distance and desired deceleration is put forward according to the detected static or moving target and its simulation results in Matlab are also presented.The validity of the algorithm to calculate the reference speeds of both the ACC vehicle and the targeted car according to the vector quadrangle composed of the relative distance, the relative azimuth angle, the relative speeds of the vehicles has also been demonstrated through numerical example in Matlab. New laws to obtain the desired deceleration by estimating the braking force according to the vehicle analyses force equation are established too.

  18. RFQD a decelerating radio frequency quadrupole for the CERN antiproton facility

    CERN Document Server

    Bylinsky, Y.; Pirkl, W.

    2000-01-01

    The RFQD is designed to decelerate antiprotons of momentum 100 MeV/c (kinetic energy 5.33 MeV) down to a kinetic energy variable between ~10 keV and 120 keV. Inside the RFQ body, at ground potential, the rf structure of the four-rod type is mounted on insulating supports. It can be biased between ±60 kV dc to achieve the continuous adjustment of the output energy required by the ASACUSA experiment at the CERN Antiproton Decelerator AD. The different parts of the system are described and the present status reported.

  19. An Analysis of the Assembly Path Planning of Decelerator Based on Virtual Technology

    Science.gov (United States)

    Jin, Xiangyang; Zhang, Tiefeng; Yang, Hanlin

    According to structural features of different components of decelerator, the general rule of three-dimensional solid modeling of components is summarized, the three-dimensional model of gear stand is built, all components are organized into groups to form a whole partial assembly, and various kinds of assembly relations are added among components, as well as hierarchical relations. Then the assembly path of decelerator is programmed, the sequence of assembling components is decided, and finally the assembly simulation is completed, laying the foundation for component disassembly. Virtual assembly technology helps to introduce advanced design approaches, improve the quality of products, reduce development cost and shorten development cycle.

  20. Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk.

    Science.gov (United States)

    Giantsoudi, Drosoula; Adams, Judith; MacDonald, Shannon M; Paganetti, Harald

    2017-02-01

    In proton therapy of posterior fossa tumors, at least partial inclusion of the brainstem in the target is necessary because of its proximity to the tumor and required margins. Additionally, the preferred beam geometry results in directing the field distal edge toward this critical structure, raising concerns for brainstem toxicity. Some treatment techniques place the beam's distal edge within the brainstem (dose-sparing techniques), and others avoid elevated linear energy transfer (LET) of the proton field by placing the distal edge beyond it (LET-sparing techniques). Hybrid approaches are also being used. We examine the dosimetric efficacy of these techniques, accounting for LET-dependent and dose-dependent variable relative biologic effectiveness (RBE) distributions. Six techniques were applied in ependymoma cases: (a) 3-field dose-sparing; (b) 3-field LET-sparing; (c) 2-field dose-sparing, wide angles; (d) 2-field LET-sparing, wide angles; (e) 2-field LET-sparing, steep angles; and (f) 2-field LET-sparing with feathered distal end. Monte Carlo calculated dose, LET, and RBE-weighted dose distributions were compared. Decreased LET values in the brainstem by LET-sparing techniques were accompanied by higher, not statistically significant, median dose: 53.6 Gy(RBE), 53.4 Gy(RBE), and 54.3 Gy(RBE) for techniques (b), (d), and (e) versus 52.1 Gy(RBE) for technique (a). Accounting for variable RBE distributions, the brainstem volume receiving at least 55 Gy(RBE) increased from 72.5% for technique (a) to 80.3% for (b) (Ptechnique (c) to 77.6% for (d) (Ptechniques compared with the corresponding dose-sparing (P=.03 and .004). Extending the proton range beyond the brainstem to reduce LET results in clinically comparable maximum radiobiologic effective dose to this sensitive structure. However this method significantly increasing the brainstem volume receiving RBE-weighted dose higher than 55 Gy(RBE) with possible consequences based on known dose-volume parameters

  1. Differential expression and prognostic significance of GLUT1 according to histologic type of non-small-cell lung cancer and its association with volume-dependent parameters.

    Science.gov (United States)

    Koh, Young Wha; Lee, Su Jin; Park, Seong Yong

    2017-02-01

    We evaluated glucose transporter type 1 (GLUT1) and carbonic anhydrase IX (CAIX) expression, together with volume-based(18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) parameters, in non-small cell lung cancer (NSCLC) patients, and examined the prognostic significance of those parameters according to its histologic subtype. A total of 269 patients, who underwent surgical resection for NSCLC, were reviewed retrospectively. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values were measured by preoperative (18)F-fluorodeoxyglucose positron emission tomography computed tomography. GLUT1 and CAIX expression was evaluated using immunohistochemical method. The mean MTV and TLG values were 30.0±57.1 and 165.4±361.3, respectively, and were significantly higher in patients with squamous cell carcinoma than with adenocarcinoma (p=0.047 for MTV; p=0.042 for TLG). GLUT1 expression was identified in 99% of squamous cell carcinoma and 50% of adenocarcinoma patients. MTV and TLG values were significantly higher in GLUT1-positive than GLUT-negative adenocarcinomas; however, CAIX expression did not show this pattern. GLUT1-positive adenocarcinoma patients had a lower OS than GLUT1-negative patients (p<0.001), whereas CAIX-positive and CAIX-negative patients showed similar OS rates (p=0.226). Patients with high MTV and TLG values showed lower OS rates than those with low MTV and TLG values. Multivariate analysis showed that GLUT1 positivity was an independent risk factor for a lower OS rate in lung adenocarcinoma patients (hazard ratio=2.574, p=0.016). GLUT1 expression was associated with micropapillary/solid histology, lymphovascular invasion, and advanced pTNM stage. MTV and TLG values, and GLUT1 expression, significantly differed between patients with squamous cell carcinoma and adenocarcinoma. High GLUT1 expression levels were significantly associated with MTV and TLG values and adverse clinical outcomes in patients with adenocarcinoma. Copyright

  2. The prognostic value of baseline {sup 18}F-FDG PET/CT in steroid-naive large-vessel vasculitis: introduction of volume-based parameters

    Energy Technology Data Exchange (ETDEWEB)

    Dellavedova, L. [Ospedale Civile di Legnano, PET/CT Center - Nuclear Medicine Department, Legnano (Italy); University of Milan, Department of Health Sciences, Milan (Italy); Carletto, M.; Maffioli, L.S. [Ospedale Civile di Legnano, PET/CT Center - Nuclear Medicine Department, Legnano (Italy); Faggioli, P.; Sciascera, A.; Mazzone, A. [Ospedale Civile di Legnano, Internal Medicine Department, Legnano (Italy); Del Sole, A. [University of Milan, Department of Health Sciences, Milan (Italy)

    2016-02-15

    The aim of this study was to analyse if the result of a baseline {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT scan, in large-vessel vasculitis (LVV) patients, is able to predict the course of the disease, not only in terms of presence/absence of final complications but also in terms of favourable/complicated progress (response to steroid therapy, time to steroid suspension, relapses, etc.). A total of 46 consecutive patients, who underwent {sup 18}F-FDG PET/CT between May 2010 and March 2013 for fever of unknown origin (FUO) or suspected vasculitis (before starting corticosteroid therapy), were enrolled. The diagnosis of LVV was confirmed in 17 patients. Considering follow-up results, positive LVV patients were divided into two groups, one characterized by favourable (nine) and the other by complicated progress (eight), on the basis of presence/absence of vascular complications, presence/absence of at least another positive PET/CT during follow-up and impossibility to comply with the tapering schedule of the steroid due to biochemical/symptomatic relapse. Vessel uptake in subjects of the two groups was compared in terms of intensity and extension. To evaluate the extent of active disease, we introduced two volume-based parameters: ''volume of increased uptake'' (VIU) and ''total lesion glycolysis'' (TLG). The threshold used to calculate VIU on vessel walls was obtained by the ''vessel to liver'' ratio by means of receiver-operating characteristic analysis and was set at 0.92 x liver maximum standardized uptake value in each patient. Measures of tracer uptake intensity were significantly higher in patients with complicated progress compared to those with a favourable one (p < 0.05). Measures of disease extension were even more significant and TLG emerged as the best parameter to separate the two groups of patients (p = 0.01). This pilot study shows that, in LVV patients, the

  3. Does Missing Classes Decelerate Student Exam Performance Progress? Empirical Evidence and Policy Implications

    Science.gov (United States)

    Lin, Tin-Chun

    2014-01-01

    A total of 389 business students in undergraduate introductory microeconomics classes in spring 2007, 2009, and 2011, and fall 2012 participated in an exam performance progress study. Empirical evidence suggested that missing classes decelerates and hampers high-performing students' exam performance progress. Nevertheless, the evidence does…

  4. Low Density Supersonic Decelerator (LDSD) Supersonic Flight Dynamics Test (SFDT) Plume Induced Environment Modelling

    Science.gov (United States)

    Mobley, B. L.; Smith, S. D.; Van Norman, J. W.; Muppidi, S.; Clark, I

    2016-01-01

    Provide plume induced heating (radiation & convection) predictions in support of the LDSD thermal design (pre-flight SFDT-1) Predict plume induced aerodynamics in support of flight dynamics, to achieve targeted freestream conditions to test supersonic deceleration technologies (post-flight SFDT-1, pre-flight SFDT-2)

  5. Nonstressed antepartum heart-rate monitoring - implications of decelerations after spontaneous contractions

    NARCIS (Netherlands)

    Visser, G. H. A.; REDMAN, CWG; HUISJES, HJ; TURNBULL, AC

    1980-01-01

    Fetal outcome in 98 patients with spontaneous antepartum late decelerations was studied by combining the data of two obstetric departments. Heart rate variability was used to classify the different patterns into two categories: terminal and decelerative. In 14 of the 47 pregnancies in which a termin

  6. Longitudinal progression of fetal short-term variation and average acceleration and deceleration capacity after antenatal maternal betamethasone application.

    Science.gov (United States)

    Weyrich, Joy; Setter, Anna; Müller, Alexander; Schmidt, Georg; Brambs, Christine E; Ortiz, Javier U; Lobmaier, Silvia M

    2017-05-01

    To analyze the effect of maternal betamethasone given for fetal lung maturation on fetal short-term variation (STV) and average acceleration and deceleration capacity (AAC/ADC). Both of these factors are calculated by phase-rectified signal averaging (PRSA) and represent new parameters to assess the fetal autonomic nervous system. A longitudinal prospective study including 26 pregnant women at risk for preterm delivery was performed. Two injections of 12mg betamethasone were administered intramuscularly at a 24h interval for lung maturation. Cardiotocography recordings were performed at defined time intervals: day 0 (before the first injection) and days 1, 2, 4 after the first corticosteroid administration. AAC/ADC and STV were calculated. An increase of all parameters (STV, AAC and ADC) was documented between day 0 and day 1. Between day 1 and day 2, all three indices were significantly reduced (p<0.05). STV declined by 19.8%, AAC by 10.1% and ADC by 14.8%. A normalization of these values was seen after 96h. Similar to STV, AAC/ADC shows significant changes after maternal betamethasone administration. The corticosteroid-induced transient decrease of the levels needs to be taken into account in the assessment of the fetal status to avoid misinterpretation of these parameters. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Echocardiographic Parameters and Survival in Chagas Heart Disease with Severe Systolic Dysfunction

    Energy Technology Data Exchange (ETDEWEB)

    Rassi, Daniela do Carmo, E-mail: dani.rassi@hotmail.com [Faculdade de Medicina e Hospital das Clínicas da Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil); Vieira, Marcelo Luiz Campos [Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, SP (Brazil); Arruda, Ana Lúcia Martins [Instituto de Radiologia da Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, SP (Brazil); Hotta, Viviane Tiemi [Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, SP (Brazil); Furtado, Rogério Gomes; Rassi, Danilo Teixeira; Rassi, Salvador [Faculdade de Medicina e Hospital das Clínicas da Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil)

    2014-03-15

    Echocardiography provides important information on the cardiac evaluation of patients with heart failure. The identification of echocardiographic parameters in severe Chagas heart disease would help implement treatment and assess prognosis. To correlate echocardiographic parameters with the endpoint cardiovascular mortality in patients with ejection fraction < 35%. Study with retrospective analysis of pre-specified echocardiographic parameters prospectively collected from 60 patients included in the Multicenter Randomized Trial of Cell Therapy in Patients with Heart Diseases (Estudo Multicêntrico Randomizado de Terapia Celular em Cardiopatias) - Chagas heart disease arm. The following parameters were collected: left ventricular systolic and diastolic diameters and volumes; ejection fraction; left atrial diameter; left atrial volume; indexed left atrial volume; systolic pulmonary artery pressure; integral of the aortic flow velocity; myocardial performance index; rate of increase of left ventricular pressure; isovolumic relaxation time; E, A, Em, Am and Sm wave velocities; E wave deceleration time; E/A and E/Em ratios; and mitral regurgitation. In the mean 24.18-month follow-up, 27 patients died. The mean ejection fraction was 26.6 ± 5.34%. In the multivariate analysis, the parameters ejection fraction (HR = 1.114; p = 0.3704), indexed left atrial volume (HR = 1.033; p < 0.0001) and E/Em ratio (HR = 0.95; p = 0.1261) were excluded. The indexed left atrial volume was an independent predictor in relation to the endpoint, and values > 70.71 mL/m{sup 2} were associated with a significant increase in mortality (log rank p < 0.0001). The indexed left atrial volume was the only independent predictor of mortality in this population of Chagasic patients with severe systolic dysfunction.

  8. Fast, transient cardiac accelerations and decelerations during fear conditioning in rats.

    Science.gov (United States)

    Knippenberg, J M J; Barry, R J; Kuniecki, M J; van Luijtelaar, G

    2012-02-01

    The current study reports on a number of heart rate responses observed in rats subjected to a discriminatory Pavlovian fear conditioning procedure. Rats learned that a series of six auditory pips was followed by a footshock when presented alone, but not when the pip series was preceded by a visual safety signal. Each auditory pip in the series evoked a fast transient (transient decelerations are similar to the human Evoked Cardiac Response 1 (ECR1), a brief modest deceleration evoked by simple sensory stimuli that is thought to reflect an early process of stimulus registration. Immediately following these pip-evoked decelerations, modest fast accelerations were observed. These accelerations were larger when the pip series was followed by shock than when it was not followed by shock. We propose a potential linkage between these accelerations and the human acceleratory ECR2 component, which is associated with more elaborate processing following stimulus registration; something likely to take place when the pip series predicts an aversive event. Both the ECR1- and ECR2-like responses were embedded within a slow, gradual heart rate increase across the entire pip series. This tonic increase was significantly larger on trials with footshock and is therefore probably associated with anticipatory fear of the upcoming shock. An additional special type of cardiac response was found to the first pip in the series not preceded by the safety signal; here, a much larger and more sustained deceleration was apparent. This response appears relatable to the prolonged deceleration reported in humans in response to aversive picture content. We discuss the cardiac responses found in rats in the current study in the context of heart rate responses known in the human literature.

  9. Volume perfusion CT (VPCT) for the differential diagnosis of patients with suspected cerebral vasospasm: Qualitative and quantitative analysis of 3D parameter maps

    Energy Technology Data Exchange (ETDEWEB)

    Dolatowski, K., E-mail: karoline.dolatowski@gmail.com [Department of Neuroradiology, University Medicine Göttingen, Robert-Koch-Str. 40, 37075 Göttingen (Germany); Malinova, V., E-mail: vesna.malinova@gmail.com [Department of Neurosurgery, University Medicine Göttingen, Robert-Koch-Str. 40, 37075 Göttingen (Germany); Frölich, A.M.J., E-mail: a.froelich@gmail.com [Department of Neuroradiology, University Medicine Göttingen, Robert-Koch-Str. 40, 37075 Göttingen (Germany); Schramm, R., E-mail: ramona.schramm@med.uni-goettingen.de [Department of Neuroradiology, University Medicine Göttingen, Robert-Koch-Str. 40, 37075 Göttingen (Germany); Haberland, U., E-mail: ulrike.haberland@siemens.com [Siemens AG, Healthcare Sector, Computed Tomography, H IM CR R and D PA SC, Siemensstr. 1, 91301 Forchheim (Germany); Klotz, E., E-mail: ernst.klotz@siemens.com [Siemens AG, Healthcare Sector, Computed Tomography, H IM CR R and D PA SC, Siemensstr. 1, 91301 Forchheim (Germany); Mielke, D., E-mail: dorothee.wachter@med.uni-goettingen.de [Department of Neurosurgery, University Medicine Göttingen, Robert-Koch-Str. 40, 37075 Göttingen (Germany); Knauth, M., E-mail: michael.knauth@med.uni-goettingen.de [Department of Neuroradiology, University Medicine Göttingen, Robert-Koch-Str. 40, 37075 Göttingen (Germany); Schramm, P., E-mail: Peter.Schramm@uksh.de [Department of Neuroradiology, UKSH University hospital Schleswig-Holstein Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck (Germany)

    2014-10-15

    Object: Cerebral vasospasm (CV) following subarachnoid hemorrhage (SAH) implies high risk for secondary ischemia. It requires early diagnosis to start treatment on time. We aimed to assess the utility of “whole brain” VPCT for detecting localization and characteristics of arterial vasospasm. Methods: 23 patients received a non-enhanced CT, VPCT and CTA of the brain. The distribution of ischemic lesions was analyzed on 3D-perfusion-parameter-maps of CBF, CBV, MTT, TTS, TTP, and TTD. CT-angiographic axial and coronal maximum-intensity-projections were reconstructed to determine arterial vasospasm. CT-data was compared to DSA, if performed additionally. Volume-of-interest placement was used to obtain quantitative mean VPCT values. Results: 82% patients (n = 19) had focal cerebral hypoperfusion. 100% sensitivity and 100% specificity was found for TTS (median 1.9 s), MTT (median 5.9 s) and TTD (median 7.6 s). CBV showed no significant differences. In 78% (n = 18) focal vessel aberrations could be detected either on CTA or DSA or on both. Conclusion: VPCT is a non-invasive method with the ability to detect focal perfusion deficits almost in the whole brain. While DSA remains to be the gold standard for detection of CV, VPCT has the potential to improve noninvasive diagnosis and treatment decisions.

  10. Late Toxicity After Intensity-Modulated Radiation Therapy for Localized Prostate Cancer: An Exploration of Dose-Volume Histogram Parameters to Limit Genitourinary and Gastrointestinal Toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Pederson, Aaron W.; Fricano, Janine; Correa, David; Pelizzari, Charles A. [Department of Radiation and Cellular Oncology, Pritzker School of Medicine, University of Chicago, Chicago, IL (United States); Liauw, Stanley L., E-mail: sliauw@radonc.uchicago.edu [Department of Radiation and Cellular Oncology, Pritzker School of Medicine, University of Chicago, Chicago, IL (United States)

    2012-01-01

    Purpose: To characterize the late genitourinary (GU) and gastrointestinal (GI) toxicity for prostate cancer patients treated with intensity-modulated radiation therapy (IMRT) and propose dose-volume histogram (DVH) guidelines to limit late treatment-related toxicity. Methods and Materials: In this study 296 consecutive men were treated with IMRT for adenocarcinoma of the prostate. Most patients received treatment to the prostate with or without proximal seminal vesicles (90%), to a median dose of 76 Gy. Concurrent androgen deprivation therapy was given to 150 men (51%) for a median of 4 months. Late toxicity was defined by Common Toxicity Criteria version 3.0 as greater than 3 months after radiation therapy completion. Four groupings of DVH parameters were defined, based on the percentage of rectal or bladder tissue receiving 70 Gy (V{sub 70}), 65 Gy (V{sub 65}), and 40 Gy (V{sub 40}). These DVH groupings, as well as clinical and treatment characteristics, were correlated to maximal Grade 2+ GU and GI toxicity. Results: With a median follow-up of 41 months, the 4-year freedom from maximal Grade 2+ late toxicity was 81% and 91% for GU and GI systems, respectively, and by last follow-up, the rates of Grade 2+ GU and GI toxicity were 9% and 5%, respectively. On multivariate analysis, whole-pelvic IMRT was associated with Grade 2+ GU toxicity and age was associated with Grade 2+ GI toxicity. Freedom from Grade 2+ GI toxicity at 4 years was 100% for men with rectal V{sub 70} {<=}10%, V{sub 65} {<=}20%, and V{sub 40} {<=}40%; 92% for men with rectal V{sub 70} {<=}20%, V{sub 65} {<=}40%, and V{sub 40} {<=}80%; and 85% for men exceeding these criteria (p = 0.13). These criteria were more highly associated with GI toxicity in men aged {>=}70 years (p = 0.07). No bladder dose-volume relationships were associated with the risk of GU toxicity. Conclusions: IMRT is associated with low rates of severe GU or GI toxicity after treatment for prostate cancer. Rectal dose constraints

  11. Study of limiting dosimetric parameters on lung pathology. Differences in the use of the lung-gtv and lung-ptv volumes; Estudio de los parametros dosimetricos limitantes en la patologia de pulmon diferencias en ul uso de los volumenes pulmon-gtv y pulmo-ptv

    Energy Technology Data Exchange (ETDEWEB)

    Granero Cabanero, D.; Almendros Blanco, P.; Garcia Hernanez, T.; Vicedo gonzalez, A.; Brualla, L.; Hernandez, A.; Solera, C.; Serrano, A.; Rosello, J.

    2013-07-01

    The objective of this work is to study the differences between the use of the volume of lung-GTV and lung-PTV to assess pulmonary toxicity and also to study the relationships between parameters V13, V20, V30, and mean dose of volumes lung, lung-PTV and lung-GTV. It was studied also the possible relationship between volumes of GTV, PTV and volume of lung with the dosimetric parameters described above. (Author)

  12. A unique problem of muscle adaptation from weightlessness: The deceleration deficiency

    Science.gov (United States)

    Stauber, William T.

    1989-01-01

    Decelerator problems of the knee are emphasized since the lower leg musculature is known to atrophy in response to weightlessness. However, other important decelerator functions are served by the shoulder muscles, in particular the rotator cuff muscles. Problems in these muscles often result in tears and dislocations as seen in baseball pitchers. It is noteworthy that at least one device currently exists that can measure concentric and eccentric muscle loading including a submaximal simulated free weight exercise (i.e., force-controlled) and simultaneously record integrated EMG analysis appropriate for assessment of all muscle functional activities. Studies should be undertaken to provide information as to the performance of maximal and submaximal exercise in space travelers to define potential problems and provide rationale for prevention.

  13. Novel tandem quadrupole-acceleration-deceleration mass spectrometer for neutralization-reionization studies.

    Science.gov (United States)

    Turecek, F; Gu, M; Shaffer, S A

    1992-07-01

    A new tandem mass spectrometer of the quadrupole-acceleration lens-deceleration. lens-quadrupole (QADQ) configuration is described. The instrument is designed for neutralization-reionization studies and consists of a 2000-u quadrupole mass analyzer as MS-I, an acceleration electrostatic lens, a series of three differentially pumped collision cells, and an electrostatic deceleration lens, energy filter, and another 2000-u quadrupole mass analyzer as MS-II. The ion optical system achieves high total ion transmission for 5-9-keV ions. Unit mass resolution in neutralization-reionization mass spectra of aromatic compounds is demonstrated. Mass, kinetic energy, and linked scans at various levels of mass resolution and sensitivity are described.

  14. One-Dimensional Traffic Model to Consider Priority of the Stochastic Deceleration

    Institute of Scientific and Technical Information of China (English)

    XUE Yu

    2004-01-01

    A one-dimensional cellular automaton model of traffic flow is proposed to introduce the different delay probabilities in the steps of rules and the stochastic deceleration prior to the deterministic one when the anticipation velocity of vehicle is larger than the headway. The fundamental diagram shows the capacity of road more approaches to the observed data compared with that by the NaSch model. Moreover, the model is able to reproduce the complicated behavior of the real fraffic, such as the metastability state, the separation of different phases and the effect of hysteresis.It is concluded that the order arrangement of the stochastic deceleration and deterministic acceleration has indeed remarkable effect on traffic flow and the modification presented in this paper is reasonable and realistic.

  15. Reefing of Quarter Spherical Ribbon Parachutes Used in the Ares I First Stage Deceleration System

    Science.gov (United States)

    Schmidt, Jason R.; McFadden, Peter G.

    2009-01-01

    This paper introduces the parachutes that have been drop tested in support of the Ares I first stage deceleration system development. The results of the tests show that the reefing ratios for these quarter spherical ribbon parachutes provide the same reefed drag area as historical conical ribbon parachutes. Two sources are investigated for properly normalizing the parachutes relative to their suspension line length, and one is found to be superior.

  16. Ablative Stabilization of the Deceleration-Phase Rayleigh-Taylor Instability, control No. 2000-107

    Energy Technology Data Exchange (ETDEWEB)

    Lobatchev, V.; Betti, R.

    2000-10-01

    The growth rates of the deceleration-phase Rayleigh-Taylor instability for imploding inertial confinement fusion capsules are calculated and compared with the results of numerical simulations. It is found that the unstable spectrum and the growth rates are significantly reduced by the finite ablation flow at the shell's inner surface. For typical direct-drive capsules designed for the National Ignition Facility, the unstable spectrum exhibits a cutoff for {ell} {approx} 90.

  17. Venus In Situ Explorer Mission design using a mechanically deployed aerodynamic decelerator

    Science.gov (United States)

    Smith, B.; Venkatapathy, E.; Wercinski, P.; Yount, B.; Prabhu, D.; Gage, P.; Glaze, L.; Baker, C.

    The Venus In Situ Explorer (VISE) Mission addresses the highest priority science questions within the Venus community outlined in the National Research Council's Decadal Survey. The heritage Venus atmospheric entry system architecture, a 45° sphere-cone rigid aeroshell with a carbon phenolic thermal protection system, may no longer be the preferred entry system architecture compared to other viable alternatives being explored at NASA. A mechanically-deployed aerodynamic decelerator, known as the Adaptive Deployable Entry and Placement Technology (ADEPT), is an entry system alternative that can provide key operational benefits and risk reduction compared to a rigid aeroshell. This paper describes a mission feasibility study performed with the objectives of identifying potential adverse interactions with other mission elements and establishing requirements on decelerator performance. Feasibility is assessed through a launch-to-landing mission design study where the Venus Intrepid Tessera Lander (VITaL), a VISE science payload designed to inform the Decadal Survey results, is repackaged from a rigid aeroshell into the ADEPT decelerator. It is shown that ADEPT reduces the deceleration load on VITaL by an order of magnitude relative to a rigid aeroshell. The more benign entry environment opens up the VISE mission design environment for increased science return, reduced risk, and reduced cost. The ADEPT-VITAL mission concept of operations is presented and details of the entry vehicle structures and mechanisms are given. Finally, entry aerothermal analysis is presented that defines the operational requirements for a revolutionary structural-TPS material employed by ADEPT: three-dimensionally woven carbon cloth. Ongoing work to mitigate key risks identified in this feasibility study is presented.

  18. Higgs Field in Universe: Long-Term Oscillation and Deceleration/Acceleration Phases

    Directory of Open Access Journals (Sweden)

    Vladimir Dzhunushaliev

    2014-01-01

    Full Text Available It is shown that the Einstein gravity and Higgs scalar field have (a a long-term oscillation phase; (b cosmological regular solutions with deceleration/acceleration phases. The first has a preceding contracting and subsequent expanding phases and between them there exists an oscillating phase with arbitrary time duration. The behavior of the second solution near to a flex point is in detail considered.

  19. On the deceleration of FRI jets: mass loading by stellar-winds

    CERN Document Server

    Perucho, Manel; Laing, Robert A; Hardee, Philip E

    2014-01-01

    Jets in low-luminosity radio galaxies are known to decelerate from relativistic speeds on parsec scales to mildly or sub-relativistic speeds on kiloparsec scales. Several mechanisms have been proposed to explain this effect, including strong reconfinement shocks and the growth of instabilities (both leading to boundary-layer entrainment) and mass loading from stellar winds or molecular clouds. We have performed a series of axisymmetric simulations of the early evolution of jets in a realistic ambient medium to probe the effects of mass loading from stellar winds using the code Ratpenat. We study the evolution of Fanaroff-Riley Class I (FRI) jets, with kinetic powers L_j \\sim 1.e41-1.e44 erg/s, within the first 2 kpc of their evolution, where deceleration by stellar mass loading should be most effective. Mass entrainment rates consistent with present models of stellar mass loss in elliptical galaxies produce deceleration and effective decollimation of weak FRI jets within the first kiloparsec. However, powerfu...

  20. Cineradiographic Analysis of Mouse Postural Response to Alteration of Gravity and Jerk (Gravity Deceleration Rate

    Directory of Open Access Journals (Sweden)

    Katsuya Hasegawa

    2014-04-01

    Full Text Available The ability to maintain the body relative to the external environment is important for adaptation to altered gravity. However, the physiological limits for adaptation or the disruption of body orientation are not known. In this study, we analyzed postural changes in mice upon exposure to various low gravities. Male C57BL6/J mice (n = 6 were exposed to various gravity-deceleration conditions by customized parabolic flight-maneuvers targeting the partial-gravity levels of 0.60, 0.30, 0.15 and μ g (<0.001 g. Video recordings of postural responses were analyzed frame-by-frame by high-definition cineradiography and with exact instantaneous values of gravity and jerk. As a result, the coordinated extension of the neck, spine and hindlimbs was observed during the initial phase of gravity deceleration. Joint angles widened to 120%–200% of the reference g level, and the magnitude of the thoracic-curvature stretching was correlated with gravity and jerk, i.e., the gravity deceleration rate. A certain range of jerk facilitated mouse skeletal stretching efficiently, and a jerk of −0.3~−0.4 j (g/s induced the maximum extension of the thoracic-curvature. The postural response of animals to low gravity may undergo differential regulation by gravity and jerk.

  1. Charge-exchange cross sections and beam lifetimes for stored and decelerated bare uranium ions

    Energy Technology Data Exchange (ETDEWEB)

    Stoehlker, T. [Frankfurt Univ. (Germany). Inst. fuer Kernphysik]|[Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany); Ludziejewski, T.; Reich, H.; Bosch, F.; Franzke, B.; Kozhuharov, C.; Menzel, G.; Mokler, P.H.; Nolden, F.; Steck, M. [Frankfurt Univ. (Germany). Inst. fuer Kernphysik; Dunford, R.W. [Argonne National Lab., IL (United States). Physics Div.; Eichler, J. [Hahn-Meitner-Institut Berlin GmbH (Germany). Bereich Theoretische Physik]|[Freie Univ. Berlin (Germany). Fachbereich Physik; Rymuza, P. [Soltan Inst. for Nuclear Studies, Otwock-Swierk (Poland); Stachura, Z. [Institute of Nuclear Physics, Cracow (Poland); Swiat, P.; Warczak, A. [Uniwersytet Jagiellonski, Cracow (Poland). Inst. Fizyki; Winkler, T. [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany)

    1998-08-01

    Charge-exchange cross sections and beam lifetimes are studied for decelerated bare uranium ions at the ESR storage ring. By deceleration from the initial energy of 358 MeV/u down to various energies as low as 49 MeV/u, i.e. far below the production energy of bare ionic species, the electron pick-up cross sections were obtained for collisions with N{sub 2}, Ar, CH{sub 4} and Kr gaseous targets. The measured cross sections and beam lifetimes are compared with the theoretical results for radiative and non-radiative electron capture. The present data along with the theoretical approximations discussed, provide a solid basis for the estimation of beam lifetimes for decelerated bare high-Z ions. Moreover, a normalization procedure is proposed, in which absolute total charge-exchange cross sections are derived by normalizing the simultaneously measured yield of K-REC photons to rigorously calculated relativistic cross sections. This method along with the unprecedented beam conditions at the ESR storage ring, allows a significant improvement in the accuracy of cross section data. (orig.)

  2. Rigging Test Bed Development for Validation of Multi-Stage Decelerator Extractions

    Science.gov (United States)

    Kenig, Sivan J.; Gallon, John C.; Adams, Douglas S.; Rivellini, Tommaso P.

    2013-01-01

    The Low Density Supersonic Decelerator project is developing new decelerator systems for Mars entry which would include testing with a Supersonic Flight Dynamics Test Vehicle. One of the decelerator systems being developed is a large supersonic ringsail parachute. Due to the configuration of the vehicle it is not possible to deploy the parachute with a mortar which would be the preferred method for a spacecraft in a supersonic flow. Alternatively, a multi-stage extraction process using a ballute as a pilot is being developed for the test vehicle. The Rigging Test Bed is a test venue being constructed to perform verification and validation of this extraction process. The test bed consists of a long pneumatic piston device capable of providing a constant force simulating the ballute drag force during the extraction events. The extraction tests will take place both inside a high-bay for frequent tests of individual extraction stages and outdoors using a mobile hydraulic crane for complete deployment tests from initial pack pull out to canopy extraction. These tests will measure line tensions and use photogrammetry to track motion of the elements involved. The resulting data will be used to verify packing and rigging as well, as validate models and identify potential failure modes in order to finalize the design of the extraction system.

  3. Aerodynamic Models for the Low Density Supersonic Decelerator (LDSD) Test Vehicles

    Science.gov (United States)

    Van Norman, John W.; Dyakonov, Artem; Schoenenberger, Mark; Davis, Jody; Muppidi, Suman; Tang, Chun; Bose, Deepak; Mobley, Brandon; Clark, Ian

    2016-01-01

    An overview of aerodynamic models for the Low Density Supersonic Decelerator (LDSD) Supersonic Flight Dynamics Test (SFDT) campaign test vehicle is presented, with comparisons to reconstructed flight data and discussion of model updates. The SFDT campaign objective is to test Supersonic Inflatable Aerodynamic Decelerator (SIAD) and large supersonic parachute technologies at high altitude Earth conditions relevant to entry, descent, and landing (EDL) at Mars. Nominal SIAD test conditions are attained by lifting a test vehicle (TV) to 36 km altitude with a helium balloon, then accelerating the TV to Mach 4 and 53 km altitude with a solid rocket motor. Test flights conducted in June of 2014 (SFDT-1) and 2015 (SFDT-2) each successfully delivered a 6 meter diameter decelerator (SIAD-R) to test conditions and several seconds of flight, and were successful in demonstrating the SFDT flight system concept and SIAD-R technology. Aerodynamic models and uncertainties developed for the SFDT campaign are presented, including the methods used to generate them and their implementation within an aerodynamic database (ADB) routine for flight simulations. Pre- and post-flight aerodynamic models are compared against reconstructed flight data and model changes based upon knowledge gained from the flights are discussed. The pre-flight powered phase model is shown to have a significant contribution to off-nominal SFDT trajectory lofting, while coast and SIAD phase models behaved much as predicted.

  4. Status of deceleration and laser spectroscopy of highly charged ions at HITRAP

    Energy Technology Data Exchange (ETDEWEB)

    Andelkovic, Zoran, E-mail: z.andelkovic@gsi.de [GSI Helmholtzzentrum für Schwerionenforschung GmbH (Germany); Birkl, Gerhard [Technische Universität Darmstadt (Germany); Fedotova, Svetlana [GSI Helmholtzzentrum für Schwerionenforschung GmbH (Germany); Hannen, Volker [Universität Münster (Germany); Herfurth, Frank [GSI Helmholtzzentrum für Schwerionenforschung GmbH (Germany); König, Kristian [Technische Universität Darmstadt (Germany); Kotovskiy, Nikita [GSI Helmholtzzentrum für Schwerionenforschung GmbH (Germany); Maaß, Bernhard [Technische Universität Darmstadt (Germany); Vollbrecht, Jonas [Universität Münster (Germany); Murböck, Tobias [Technische Universität Darmstadt (Germany); Neidherr, Dennis [GSI Helmholtzzentrum für Schwerionenforschung GmbH (Germany); Nörtershäuser, Wilfried; Schmidt, Stefan; Vogel, Manuel [Technische Universität Darmstadt (Germany); Vorobjev, Gleb [GSI Helmholtzzentrum für Schwerionenforschung GmbH (Germany); Weinheimer, Christian [Universität Münster (Germany)

    2015-11-15

    Heavy few-electron ions are relatively simple systems in terms of electron structure and offer unique opportunities to conduct experiments under extremely large electromagnetic fields that exist around their nuclei. However, the preparation of highly charged ions (HCI) has remained the major challenge for experiments. As an extension of the existing GSI accelerator facility, the HITRAP facility was conceived as a multi-stage decelerator for HCI produced at high velocity. It is designed to prepare bunches of around 10{sup 5} HCI and to deliver them at low energies to various experiments. One of these experiments is SpecTrap, aiming for laser spectroscopy of trapped, cold HCI. We present the latest results on deceleration of ions in a radio-frequency quadrupole, synchrotron cooling of electrons in a trap as a preparation step for the prospective electron cooling of the HCI decelerated in HITRAP, as well as laser cooling of singly charged Mg ions for sympathetic cooling of HCI in SpecTrap.

  5. Cineradiographic analysis of mouse postural response to alteration of gravity and jerk (gravity deceleration rate).

    Science.gov (United States)

    Hasegawa, Katsuya; de Campos, Priscila S; Zeredo, Jorge L; Kumei, Yasuhiro

    2014-04-24

    The ability to maintain the body relative to the external environment is important for adaptation to altered gravity. However, the physiological limits for adaptation or the disruption of body orientation are not known. In this study, we analyzed postural changes in mice upon exposure to various low gravities. Male C57BL6/J mice (n = 6) were exposed to various gravity-deceleration conditions by customized parabolic flight-maneuvers targeting the partial-gravity levels of 0.60, 0.30, 0.15 and μ g (high-definition cineradiography and with exact instantaneous values of gravity and jerk. As a result, the coordinated extension of the neck, spine and hindlimbs was observed during the initial phase of gravity deceleration. Joint angles widened to 120%-200% of the reference g level, and the magnitude of the thoracic-curvature stretching was correlated with gravity and jerk, i.e., the gravity deceleration rate. A certain range of jerk facilitated mouse skeletal stretching efficiently, and a jerk of -0.3~-0.4 j (g/s) induced the maximum extension of the thoracic-curvature. The postural response of animals to low gravity may undergo differential regulation by gravity and jerk.

  6. Continuous all-optical deceleration and single-photon cooling of molecular beams

    Science.gov (United States)

    Jayich, A. M.; Vutha, A. C.; Hummon, M. T.; Porto, J. V.; Campbell, W. C.

    2014-02-01

    Ultracold molecular gases are promising as an avenue to rich many-body physics, quantum chemistry, quantum information, and precision measurements. This richness, which flows from the complex internal structure of molecules, makes the creation of ultracold molecular gases using traditional methods (laser plus evaporative cooling) a challenge, in particular due to the spontaneous decay of molecules into dark states. We propose a way to circumvent this key bottleneck using an all-optical method for decelerating molecules using stimulated absorption and emission with a single ultrafast laser. We further describe single-photon cooling of the decelerating molecules that exploits their high dark state pumping rates, turning the principal obstacle to molecular laser cooling into an advantage. Cooling and deceleration may be applied simultaneously and continuously to load molecules into a trap. We discuss implementation details including multilevel numerical simulations of strontium monohydride. These techniques are applicable to a large number of molecular species and atoms with the only requirement being an electric dipole transition that can be accessed with an ultrafast laser.

  7. Investigation of turbulent Prandtl number subject to local acceleration and deceleration

    Science.gov (United States)

    Jung, Eunbeom; Lee, Wook; Kang, Seongwon; Iaccarino, Gianluca

    2016-11-01

    The main objective of the present study is to analyze the turbulent Prandtl number (Prt) varying over space in a wall-bounded turbulent flow under local acceleration and deceleration. The Prt shows the opposite trends for the conditions of acceleration and deceleration. In order to explain these phenomena, the convection velocity from the space-time correlation is investigated. It is shown that small-scale motions experience larger acceleration and deceleration compared to large-scale ones. Also, a discrepancy between the momentum and heat transfer at small scales results in the spatially varying Prt. The budgets of the turbulent kinetic energy and temperature variance show a hint for the variation of Prt. The results from DNS and RANS with a constant Prt are compared and show that RANS prediction can be improved by using a modeled Prt. From the turbulent statistics, a few flow variables showing higher correlations with Prt are identified. Based on this, simple phenomenological models are devised and the corresponding simulations show a more accurate prediction of the heat transfer rate. Corresponding author.

  8. Study on Decelerating Performance of Hydraulic Driving Control Rod%水压驱动控制棒减速性能研究

    Institute of Scientific and Technical Information of China (English)

    秦本科; 许星星; 薄涵亮; 宋威

    2015-01-01

    The control rod hydraulic driving line (CRHDL) is a new type of in‐vessel control rod driving technology .The control rod hydraulic deceleration device (CRHDD) is one of the key components of the CRHDL . To prevent the control rod cross wing from being permanently deformed or damaged during the fast dropping rod process ,the CRHDD performs the fast dropping rod deceleration function through the interworking of the slow‐down plug and water filled cylinder .The hydraulic driving rod deceleration test was conducted to get the slow‐down mechanism of the CRHDD ,and a dynamic model was developed to analyze the key parameters of the decelerating process .The model calculation result agrees well with the experiment result , which verifies the accuracy of the model .Then the CRHDD performance calculation under reactor high temperature working condition was carried out through the CRHDD dynamic model . The above work lays solid foundation for the design and upgrade of the CRHDD .%控制棒水压驱动线是一种新型的内置式控制棒驱动技术,控制棒水力减速装置是水压驱动线的关键部件之一,通过水力减速片和减速筒体的配合对控制棒进行减速,降低快速落棒末端的冲击速度,避免控制棒的变形和损坏。完成了水压驱动线快速落棒减速实验,对减速过程机理进行了分析,在此基础上建立了水压驱动线快速落棒减速理论模型,理论模型的求解结果与实验结果符合很好,从而验证了理论模型的正确性。通过该模型对热态工况下水压驱动线的快速落棒性能进行了分析,为控制棒水压驱动线减速环节的设计和优化奠定了基础。

  9. Accretion-caused deceleration of a gravitationally powerful compact stellar object moving within a dense Fermi gas

    CERN Document Server

    Tito, Elizabeth P

    2016-01-01

    We consider accretion-caused deceleration of a gravitationally-powerful compact stellar object traveling within a cold Fermi-gas medium. We provide analytical and numerical estimates of the effect manifestation.

  10. Prognostic significance and predictive performance of volume-based parameters of F-18 FDG PET/CT in squamous cell head and neck cancers

    Directory of Open Access Journals (Sweden)

    Sait Sager

    2014-01-01

    Conclusion: Metabolic tumor volume (MTV represents tumor burden, which shows F18-Fluorodeoxyglucose uptake and has a potential value in predicting short-term outcome and disease-free survival in patients with head and neck cancer.

  11. Faranoff-Riley type I jet deceleration at density discontinuities "Relativistic hydrodynamics with realistic equation of state"

    OpenAIRE

    Meliani, Z.; Keppens, R.; Giacomazzo, B.

    2008-01-01

    We propose a model that could explain the sudden jet deceleration in active galactic nuclei, thereby invoking density discontinuities. Motivated particularly by recent indications from HYbrid MOrphology Radio Sources (HYMORS) that Fanaroff-Riley classification is induced in some cases by variations in the density of the external medium. We explore how one-sided jet deceleration and a transition to FR I type can occur in HYMORS, which start as FR II (and remain so on the other side). Methods. ...

  12. Derivation of parameters necessary for the evaluation of performance of sites for deep geological repositories with particular reference to bedded salt, Livermore, California. Volume I. Main text

    Energy Technology Data Exchange (ETDEWEB)

    Ashby, J.P.; Rawlings, G.E.; Soto, C.A.; Wood, D.F.; Chorley, D.W.

    1979-12-01

    A survey of parameters to be considered in the evaluation of sites for deep geologic nuclear waste repositories is presented. As yet, no comprehensive site selection procedure or performance evaluation approach has been adopted. A basis is provided for the development of parameters by discussing both site selection and performance evaluation. Three major groups of parameters are considered in this report: geologic, mining/rock mechanics, and hydrogeologic. For each type, the role of the parameter in the evaluation of repository sites is discussed. The derivation of the parameter by measurement, correlation, inference, or other method is discussed. Geologic parameters define the framework of the repository site and can be used in development of conceptual models and the prediction of long-term performance. Methods for deriving geological parameters include mapping, surveying, drilling, geophysical investigation, and historical and regional analysis. Rock mechanics/mining parameters are essential for the prediction of short-term performance and the development of initial conditions for modeling of long-term performance. Rock mechanics/mapping parameters can be derived by field or laboratory investigation, correlation, and theoretically or empirically based inference. Hydrogeologic parameters are the most important for assessment of long-term radionuclide confinement, since transport throughout the regional hydrogeologic system is the most likely mode of radionuclide escape from geologic repositories. Hydrogeologic parameters can be derived by hydrogeologic mapping and interpretation, hydrogeologic system modeling, field measurements, and lab tests. Procedures used in determination and statistical evaluation of geologic and rock mechanics parameters are discussed.

  13. Average acceleration and deceleration capacity of fetal heart rate in normal pregnancy and in pregnancies complicated by fetal growth restriction.

    Science.gov (United States)

    Graatsma, E M; Mulder, E J H; Vasak, B; Lobmaier, S M; Pildner von Steinburg, S; Schneider, K T M; Schmidt, G; Visser, G H A

    2012-12-01

    To study fetal heart rate (FHR), its short term variability (STV), average acceleration capacity (AAC), and average deceleration capacity (ADC) throughout uncomplicated gestation, and to perform a preliminary comparison of these FHR parameters between small-for dates (SFD) and control fetuses. Prospective observational study of 7 h FHR-recordings obtained with a fetal-ECG monitor in the second half of uncomplicated pregnancies (n = 90) and pregnancies complicated by fetal SFD (n = 30). FHR and STV were calculated according to established analysis. True beat-to-beat FHR, recorded at 1 ms accuracy, was used to calculate AAC and ADC using Phase Rectified Signal Averaging (PRSA). Mean values of FHR, STV, AAC, and ADC derived from recordings in SFD fetuses were compared with the reference curves. Compared with the control group the mean z-scores for STV, AAC, and ADC in SFD fetuses were lower by 1.0 SD, 1.5 SD, and 1.7 SD, respectively (p < 0.0001 for all comparisons). In SFD fetuses, both the AAC and ADC z-scores were lower than the STV z-scores (p < 0.02 and p < 0.002, respectively). Analysis of the AAC and ADC as recorded with a high resolution fECG recorder may differentiate better between normal and SFD fetuses than STV.

  14. The clinical significance of detection to heart rate deceleration capacity and heart rate variability in patients with chronic heart failure

    Directory of Open Access Journals (Sweden)

    Jiang-rong Zhou

    2015-01-01

    Full Text Available Objective: To study the change of heart rate deceleration capacity ( DC and heart rate variability in patients with chronic heart failure (CHF and its relationship with left ventricular ejection fraction (LVEF. Methods: DC, LVEF, time and frequency domain parameters of HRV were measured in 66 patients with CHF and 34 healthy adults (control group by using 24h Holter recordings and Echocardiography. The standard deviation of normal R-R intervals( SDNN, squares of differences between adjacent NN intervals ( RMSSD,low frequency power( LFn and high frequency power( HFn and the changes of LVEF were compared between  the two groups,the relationship between DC,LVEF and HRV were studied in patients with CHF. Results: The median value of DC in the patients with CHF was significantly lower than that in control group( 3.1 ± 2.4 ms vs 7.2 ± 1.3 ms,P <0.01.Incidence of abnormal DC in the CHF group was 57.5%,which was significantly higher than that in the control group (P <0.01.The HRV index, including SDNN、RMSSD、LFn、HFn, in the CHF group was significantly lower than that in normal control group (P < 0.01. Significant positive correlation between HRV index and LVEF were confirmed (P < 0.01. Conclusions: DC and HRV index are lower in patients with CHF and have a good correlation with the left ventricular ejection fraction.

  15. Effects of drop acceleration and deceleration on particle capture in a cross-flow gravity tower at intermediate drop Reynolds numbers.

    Science.gov (United States)

    Kumar, Anoop; Gupta, S K; Kale, S R

    2007-04-01

    Cross-flow gravity towers are particle scrubbing devices in which water is sprayed from the top into particle-laden flow moving horizontally. Models for predicting particle capture assume drops traveling at terminal velocity and potential flow (ReD > 1000) around it, however, Reynolds numbers in the intermediate range of 1 to 1000 are common in gravity towers. Drops are usually injected at velocities greater than their terminal velocities (as in nozzles) or from near rest (perforated tray) and they accelerate/decelerate to their terminal velocity in the tower. Also, the effects of intermediate drop Reynolds number on capture efficiency have been simulated for (a) drops at their terminal velocity and (b) drops accelerating/decelerating to their terminal velocity. Tower efficiency based on potential flow about the drop is 40%-50% greater than for 200 mm drops traveling at their terminal velocity. The corresponding values for 500 mm drops are about 10%-20%. The drop injection velocity is important operating parameter. Increase in tower efficiency by about 40% for particles smaller than 5 mm is observed for increase in injection velocity from 0 to 20 m/s for 200 and 500mm drops.

  16. Categorization of Fetal Heart Rate Decelerations in American and European Practice: Importance and Imperative of Avoiding Framing and Confirmation Biases.

    Science.gov (United States)

    Sholapurkar, Shashikant L

    2015-09-01

    Interpretation of electronic fetal monitoring (EFM) remains controversial and unsatisfactory. Fetal heart rate (FHR) decelerations are the commonest aberrant feature on cardiotocographs and considered "center-stage" in the interpretation of EFM. A recent American study suggested that the lack of correlation of American three-tier system to neonatal acidemia may be due to the current peculiar nomenclature of FHR decelerations leading to loss of meaning. The pioneers like Hon and Caldeyro-Barcia classified decelerations based primarily on time relationship to contractions and not on etiology per se. This critical analysis debates pros and cons of significant anchoring/framing and confirmation biases in defining different types of decelerations based primarily on the shape (slope) or time of descent. It would be important to identify benign early decelerations correctly to avoid unnecessary intervention as well as to improve the positive predictive value of the other types of decelerations. Currently the vast majority of decelerations are classed as "variable". This review shows that the most common rapid decelerations during contractions with trough corresponding to peak of contraction cannot be explained by "cord-compression" hypothesis but by direct/pure (defined here as not mediated through baro-/chemoreceptors) or non-hypoxic vagal reflex. These decelerations are benign, most likely and mainly a result of head-compression and hence should be called "early" rather than "variable". Standardization is important but should be appropriate and withstand scientific scrutiny. Significant framing and confirmation biases are necessarily unscientific and the succeeding three-tier interpretation systems and structures embodying these biases would be dysfunctional and clinically unhelpful. Clinical/pathophysiological analysis and avoidance of flaws/biases suggest that a more physiological and scientific categorization of decelerations should be based on time relationship to

  17. Deceleration versus acceleration universe in different frames of F(R) gravity

    Science.gov (United States)

    Bahamonde, Sebastian; Odintsov, Sergei D.; Oikonomou, V. K.; Tretyakov, Petr V.

    2017-03-01

    In this paper we study the occurrence of accelerating universe versus decelerating universe between the F (R) gravity frame (Jordan frame) and non-minimally coupled scalar field theory frame, and the minimally coupled scalar field theory frame (Einstein frame) for various models. As we show, if acceleration is imposed in one frame, it will not necessarily correspond to an accelerating metric when transformed in another frame. As we will demonstrate, this issue is model and frame-dependent but it seems there is no general scheme which permits to classify such cases.

  18. Production of clinically useful positron emitter beams during carbon ion deceleration

    Science.gov (United States)

    Lazzeroni, M.; Brahme, A.

    2011-03-01

    In external beam radiation therapy, radioactive beams offer the best clinical solution to simultaneously treat and in vivo monitor the dose delivery and tumor response using PET or PET-CT imaging. However, difficulties mainly linked to the low production efficiency have so far limited their use. This study is devoted to the analysis of the production of high energy 11C fragments, preferably by projectile fragmentation of a stable monodirectional and monoenergetic primary 12C beam in different absorbing materials (decelerators) in order to identify the optimal elemental composition. The study was performed using the Monte Carlo code SHIELD-HIT07. The track length and fluence of generated secondary particles were scored in a uniform absorber of 300 cm length and 10 cm radius, divided into slices of 1 cm thickness. The 11C fluence build-up and mean energy variation with increasing decelerator depth are presented. Furthermore, the fluence of the secondary 11C beam was studied as a function of its mean energy and the corresponding remaining range in water. It is shown that the maximum 11C fluence build-up is high in compounds where the fraction by weight of hydrogen is high, being the highest in liquid hydrogen. Furthermore, a cost effective alternative solution to the single medium initially envisaged is presented: a two-media decelerator that comprises a first liquid hydrogen section followed by a second decelerating section made of a hydrogen-rich material, such as polyethylene (C2H4). The purpose of the first section is to achieve a fast initial 11C fluence build-up, while the second section is primarily designed to modulate the mean energy of the generated 11C beam in order to reach the tumor depth. Finally, it was demonstrated that, if the intensity of the primary 12C beam can be increased by an order of magnitude, a sufficient intensity of the secondary 11C beam is achieved for therapy and subsequent therapeutic PET imaging sessions. Such an increase in the

  19. Irreversible processes and the accelerated-decelerated phases of the Universe

    CERN Document Server

    Kremer, G M

    2004-01-01

    A model for the Universe is proposed where it is considered as a mixture of scalar and matter fields. The particle production is due to an irreversible transfer of energy from the gravitational field to the matter field and represented by a non-equilibrium pressure. This model can simulate three distinct periods of the Universe: (a) an accelerated epoch where the energy density of the scalar field prevails over the matter field, (b) a past decelerated period where the energy density of the matter field becomes more predominant than the scalar energy density, and (c) a present acceleration phase where the scalar energy density overcomes the energy density of the matter field.

  20. Review of NASA In-Space Propulsion Technology Program Inflatable Decelerator Investments

    Science.gov (United States)

    Richardson, E. H.; Mnk, M. M.; James, B. F.; Moon, S. A.

    2005-01-01

    The NASA In-Space Propulsion Technology (ISPT) Program is managed by the NASA Headquarters Science Mission Directorate and is implemented by the Marshall Space Flight Center in Huntsville, Alabama. The ISPT objective is to fund development of promising in-space propulsion technologies that can decrease flight times, decrease cost, or increase delivered payload mass for future science missions. Before ISPT will invest in a technology, the Technology Readiness Level (TRL) of the concept must be estimated to be at TRL 3. A TRL 3 signifies that the technical community agrees that the feasibility of the concept has been proven through experiment or analysis. One of the highest priority technology investments for ISPT is Aerocapture. The aerocapture maneuver uses a planetary atmosphere to reduce or alter the speed of a vehicle allowing for quick, propellantless (or using very little propellant) orbit capture. The atmosphere is used as a brake, transferring the energy associated with the vehicle's high speed into thermal energy. The ISPT Aerocapture Technology Area (ATA) is currently investing in the development of advanced lightweight ablative thermal protection systems, high temperature composite structures, and heat-flux sensors for rigid aeroshells. The heritage of rigid aeroshells extends back to the Apollo era and this technology will most likely be used by the first generation aerocapture vehicle. As a second generation aerocapture technology, ISPT is investing in three inflatable aerodynamic decelerator concepts for planetary aerocapture. They are: trailing ballute (balloon-parachute), attached afterbody ballute, and an inflatable aeroshell. ISPT also leverages the NASA Small Business Innovative Research Program for additional inflatable decelerator technology development. In mid-2004 ISPT requested an independent review of the three inflatable decelerator technologies funded directly by ISPT to validate the TRL and to identify technology maturation concerns. An

  1. The FLUKA study of the secondary particles fluence in the AD-Antiproton Decelerator target area

    CERN Document Server

    Calviani, M

    2014-01-01

    In this paper we present Monte Carlo FLUKA simulations [1, 2] carried out to investigate the secondary particles fluence emerging from the antiproton production target and their spatial distribution in the AD target area. The detailed quantitative analysis has been performed for different positions along the magnet dog-leg as well as after the main collimator. These results allow tuning the position of the new beam current transformers (BCT) in the target area, in order to have a precise pulse-by-pulse evaluation of the intensity of negative particles injected in the AD-ring before the deceleration phase.

  2. Deceleration of CMEs in the interplanetary medium: comparison of different analytic models

    Science.gov (United States)

    Corona-Romero, P.; Gonzalez-Esparza, A.

    2011-12-01

    We study the evolution of fast CMEs from near the Sun to 1 AU. There are several analytic models to describe the CME's propagation and to predict the 1 AU transit times and arrival velocities. In this work we compare the drag force (Vrsnak & Gopalswamy [2002], Cargill [2004]), mass piling up (Canto et al. [2005], Tappin [2006]) and viscous and turbulent force (Borgazzi et al. [2009]) deceleration models. We present a few study cases applying the different models and comparing the results with observations. We discuss the similarities and differences between the models.

  3. Evaluation of parameters of the HDV (V20 and dose average) in radiotherapy of lung cancer with lung volumes design adapted compounds (ITV); Evaluacion de parametros del HDV (V20 Y Dmed) en radioterapia adaptada de cancer de pulmon con diseno de volumenes pulmonares compuestos (ITV)

    Energy Technology Data Exchange (ETDEWEB)

    Monroy Anton, J. L.; Solar Tortosa, M.; Lopez Munoz, M.; Navarro Bergada, A.; Estornell Gualde, M. A.; Melchor Iniguez, M.

    2013-07-01

    Our objective was to evaluate the V20 parameters and dose average compared to a single lung volume designed with a CT study in normal breathing of the patient and the corresponding to a lung volume composed, designed from three studies of CT in different phases of the respiratory cycle. Check if there are important differences in these cases that determine the necessity of creating a composite lung volume to evaluate dose volume histogram. (Author)

  4. Prognostic value of perfusion defect volume at dual energy CTA in patients with pulmonary embolism: Correlation with CTA obstruction scores, CT parameters of right ventricular dysfunction and adverse clinical outcome

    Energy Technology Data Exchange (ETDEWEB)

    Apfaltrer, Paul, E-mail: paul.apfaltrer@medma.uni-heidelberg.de [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Bachmann, Valentin, E-mail: valentin.bachmann@googl.com [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Meyer, Mathias, E-mail: mr.meyer.mathias@gmail.com [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Henzler, Thomas, E-mail: Thomas.Henzler@umm.de [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Barraza, John M., E-mail: barraza@musc.edu [Department of Radiology and Radiological Science, Medical University of South Carolina, PO Box 250322, 169 Ashley Avenue, Charleston, SC 29425 (United States); Gruettner, Joachim, E-mail: joachim.gruettner@umm.de [1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Walter, Thomas, E-mail: Thomas.Walter2@umm.de [1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Schoepf, U. Joseph, E-mail: schoepf@musc.edu [Department of Radiology and Radiological Science, Medical University of South Carolina, PO Box 250322, 169 Ashley Avenue, Charleston, SC 29425 (United States); and others

    2012-11-15

    Purpose: To investigate the prognostic value of perfusion defect volume (PDvol) at dual-energy-CT-angiography (DE-CTA) in patients with acute pulmonary embolism (PE) by correlating PDvol with CTA-obstruction-scores (OS), CT parameters of right-ventricular-dysfunction (RVD), and adverse-clinical-outcome. Materials and methods: DE-CTA of 60 patients (mean age: 65 {+-} 14.4 years) with PE were analyzed. Iodine maps were generated, and normalized PDvol - defined as volume of perfusion defects/total lung volume - was quantified. Furthermore, established prognostic parameters (Qanadli and Mastora-OS, and CT parameters of RVD) were obtained. CT parameters of RVD - namely the right ventricle/left ventricle (RV/LV) diameter ratio measured on transverse sections (RV/LVtrans), four-chamber views (RV/LV4ch), and RV/LV volume ratios (RV/LVvol) - were assessed. PDvol was correlated with OS, CT parameters of RVD and adverse clinical outcome (defined as the need for intensive care treatment or death). Results: 10 of 60 patients with PE experienced adverse clinical outcome. Patients with adverse clinical outcome showed significantly higher PDvol (35 {+-} 11% vs. 23 {+-} 10%, p = 0.002), RV/LV ratios (RV/LV4ch 1.46 {+-} 0.32 vs. 1.18 {+-} 0.26, p = 0.005; RV/LVvol 2.25 {+-} 1.33 vs. 1.19 {+-} 0.56, p = 0.002) and higher Mastora global scores (52 vs. 13, p = 0.02) compared to those without adverse clinical outcome. A weak correlation was observed between PDvol and the Mastora global score (r = 0.5; p = 0.0003), as well as between PDvol and RV/LV4Ch (r = 0.432, p = 0.0006). No correlation was found between PDvol and the Qanadli score or the remainder of the RVD-CT parameters. Conclusion: The extent of perfusion defects as assessed by DE-CTA correlates with adverse clinical outcome in patients with PE. Therefore, volumetric quantification of perfusion defects at DE-CTA allows the identification of low-risk patients who do not require intensified monitoring and treatment.

  5. On the origin of Fanaroff-Riley classification of radio galaxies: Deceleration of supersonic radio lobes

    CERN Document Server

    Kawakatu, Nozomu; Nagai, Hiroshi

    2009-01-01

    We argue that the origin of "FRI/FRI{-.1em}I dichotomy" -- the division between Fanaroff-Riley class I (FRI) with subsonic lobes and class I{-.1em}I (FRI{-.1em}I) radio sources with supersonic lobes is sharp in the radio-optical luminosity plane (Owen-White diagram) -- can be explained by the deceleration of advancing radio lobes. The deceleration is caused by the growth of the effective cross-sectional area of radio lobes. We derive the condition in which an initially supersonic lobe turns into a subsonic lobe, combining the ram-pressure equilibrium between the hot spots and the ambient medium with the relation between "the hot spot radius" and "the linear size of radio sources" obtained from the radio observations. We find that the dividing line between the supersonic lobes and subsonic ones is determined by the ratio of the jet power $L_{\\rm j}$ to the number density of the ambient matter at the core radius of the host galaxy $\\bar{n}_{\\rm a}$. It is also found that there exists the maximal ratio of $(L_{\\...

  6. Systematic properties of decelerating relativistic jets in low-luminosity radio galaxies

    CERN Document Server

    Laing, R A

    2013-01-01

    We model the kiloparsec-scale synchrotron emission from jets in ten Fanaroff-Riley Class I radio galaxies for which we have sensitive, high-resolution imaging and polarimetry from the Very Large Array. We assume that the jets are intrinsically symmetrical, axisymmetric, decelerating, relativistic outflows and we infer their inclination angles and the spatial variations of their flow velocities, magnetic field structures and emissivities using a common set of fitting functions. The inferred inclinations agree well with independent indicators. The spreading rates increase rapidly, then decrease, in a flaring region. The jets then recollimate to form conical outer regions at distance r0 from the active galactic nucleus (AGN). The flaring regions are homologous when scaled by r0. At ~0.1r0, the jets brighten abruptly at the onset of a high-emissivity region and we find an outflow speed of ~0.8c, with a uniform transverse profile. Jet deceleration first becomes detectable at ~0.2r0 and the outflow often becomes sl...

  7. Ablation and deceleration of mass-driver launched projectiles for space disposal of nuclear wastes

    Science.gov (United States)

    Park, C.; Bowen, S. W.

    1981-01-01

    The energy cost of launching a projectile containing nuclear waste is two orders of magnitude lower with a mass driver than with a typical rocket system. A mass driver scheme will be feasible, however, only if ablation and deceleration are within certain tolerable limits. It is shown that if a hemisphere-cylinder-shaped projectile protected thermally with a graphite nose is launched vertically to attain a velocity of 17 km/sec at an altitude of 40 km, the mass loss from ablation during atmospheric flight will be less than 0.1 ton, provided the radius of the projectile is under 20 cm and the projectile's mass is of the order of 1 ton. The velocity loss from drag will vary from 0.4 to 30 km/sec, depending on the mass and radius of the projectile, the smaller velocity loss corresponding to large mass and small radius. Ablation is always within a tolerable range for schemes using a mass driver launcher to dispose of nuclear wastes outside the solar system. Deceleration can also be held in the tolerable range if the mass and diameter of the projectile are properly chosen.

  8. On the Origin of Fanaroff-Riley Classification of Radio Galaxies: Deceleration of Supersonic Radio Lobes

    Science.gov (United States)

    Kawakatu, Nozomu; Kino, Motoki; Nagai, Hiroshi

    2009-06-01

    We argue that the origin of "FRI/FRII dichotomy"—the division between Fanaroff-Riley class I (FRI) with subsonic lobes and class II (FRII) radio sources with supersonic lobes is sharp in the radio-optical luminosity plane (Owen-White diagram)—can be explained by the deceleration of advancing radio lobes. The deceleration is caused by the growth of the effective cross-sectional area of radio lobes. We derive the condition in which an initially supersonic lobe turns into a subsonic lobe, combining the ram pressure equilibrium between the hot spots and the ambient medium with the relation between "the hot spot radius" and "the linear size of radio sources" obtained from the radio observations. We find that the dividing line between the supersonic lobes and subsonic ones is determined by the ratio of the jet power L j to the number density of the ambient matter at the core radius of the host galaxy \\bar{n}_a. It is also found that the maximal ratio of (L_j/\\bar{n}_a) exists and its value resides in (L_j/\\bar{n}_a)_max≈ 10^{44-47} erg s^{-1} cm^{3}, taking into account considerable uncertainties. This suggests that the maximal value (L_j/\\bar{n}_a)_max separates between FRIs and FRIIs.

  9. ULF Waves Associated with Solar Wind Deceleration in the Earth's Foreshock

    Institute of Scientific and Technical Information of China (English)

    FU Hui-Shan; CAO Jin-Bin; YANG Biao; Lucek E; Rème H; Dandouras I

    2009-01-01

    Characteristics of ULF waves associated with the solar wind deceleration in the Earth's foreshock on 6-7 April 2003 is studied using the wave telescope technique. In the satellite frame, the ULF waves are the left-handed polarized and quasi anti-parallel propagating mode, with a power peak at about 18.63 mHz. The wave vector in the GSE coordinates is estimated to be k = (-4.29, 2.28, 1.21)×10~(-4)km~(-1). In the solar wind frame, the frequency of waves becomes -9.39 mHz after the Doppler shift correction. The propagation direction of the waves is thus reversed and correspondingly the polarization of the waves becomes right-handed. The above-mentioned characteristics of the ULF waves in the solar wind frame indicate that the ULF waves associated with the solar wind deceleration are the Alfven-whistler waves, which have been frequently reported in both the observations and computer simulations.

  10. The Acceleration/Deceleration Control Algorithm Based on Trapezoid-Curve Jerk in CNC Machining

    Directory of Open Access Journals (Sweden)

    Guoyong Zhao

    2013-02-01

    Full Text Available In this study, we propose the acceleration/deceleration control algorithm based on trapezoid-curve jerk in CNC machining. In aviation and mould and die industry, it is much significant to achieve high accuracy CNC machining on complex profile parts. The unsmooth Acceleration/Deceleration (ab. Acc/Dec control in feed movement is one of the main reasons to bring about machine tools impact and vibration in practical machining. After analyzing the CNC machine tools dynamic model, an Acc/Dec control algorithm based on trapezoid-curve jerk is put forward in order to avoid step change in jerk curve in the study; Moreover, the motion profile smooth control approach based on continuous jerk is developed in details to decrease machine tools impact according to various kinematics constraint conditions, such as the maximum acceleration, the maximum jerk, the machining program segment displacement, the instruction feedrate and so on; Finally, the developed Acc/Dec approach and the traditional linear Acc/Dec approach are compared in the CNC experimental table. The results reveal that the developed approach can achieve more smooth and flexible motion profile, which is helpful to minish machine tools impact and enhance parts machining surface quality.

  11. Transition from accelerated to decelerated regimes in JT and CGHS cosmologies

    CERN Document Server

    Christmann, M H; Kremer, G M; Zanetti, C M

    2004-01-01

    In this work we discuss the possibility of positive-acceleration regimes, and their transition to decelerated regimes, in two-dimensional (2D) cosmological models. We use general relativity and the thermodynamics in a 2D space-time, where the gas is seen as the sources of the gravitational field. An early-Universe model is analyzed where the state equation of van der Waals is used, replacing the usual barotropic equation. We show that this substitution permits the simulation of a period of inflation, followed by a negative-acceleration era. The dynamical behavior of the system follows from the solution of the Jackiw-Teitelboim equations (JT equations) and the energy-momentum conservation laws. In a second stage we focus the Callan-Giddings-Harvey-Strominger model (CGHS model); here the transition from the inflationary period to the decelerated period is also present between the solutions, although this result depend strongly on the initial conditions used for the dilaton field. The temporal evolution of the c...

  12. Decelerated invasion and waning-moon patterns in public goods games with delayed distribution.

    Science.gov (United States)

    Szolnoki, Attila; Perc, Matjaž

    2013-05-01

    We study the evolution of cooperation in the spatial public goods game, focusing on the effects that are brought about by the delayed distribution of goods that accumulate in groups due to the continuous investments of cooperators. We find that intermediate delays enhance network reciprocity because of a decelerated invasion of defectors, who are unable to reap the same high short-term benefits as they do in the absence of delayed distribution. Long delays, however, introduce a risk because the large accumulated wealth might fall into the wrong hands. Indeed, as soon as the curvature of a cooperative cluster turns negative, the engulfed defectors can collect the heritage of many generations of cooperators and by doing so start a waning-moon pattern that nullifies the benefits of decelerated invasion. Accidental meeting points of growing cooperative clusters may also act as triggers for the waning-moon effect, thus linking the success of cooperators with their propensity to fail in a rather bizarre way. Our results highlight that "investing in the future" is a good idea only if that future is sufficiently near and not likely to be burdened by inflation.

  13. Deceleration of fusion-fission cycles improves mitochondrial quality control during aging.

    Directory of Open Access Journals (Sweden)

    Marc Thilo Figge

    Full Text Available Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer. Accumulation of mitochondrial dysfunction was further linked to aging. Here we applied a probabilistic modeling approach integrating our current knowledge on mitochondrial biology allowing us to simulate mitochondrial function and quality control during aging in silico. We demonstrate that cycles of fusion and fission and mitophagy indeed are essential for ensuring a high average quality of mitochondria, even under conditions in which random molecular damage is present. Prompted by earlier observations that mitochondrial fission itself can cause a partial drop in mitochondrial membrane potential, we tested the consequences of mitochondrial dynamics being harmful on its own. Next to directly impairing mitochondrial function, pre-existing molecular damage may be propagated and enhanced across the mitochondrial population by content mixing. In this situation, such an infection-like phenomenon impairs mitochondrial quality control progressively. However, when imposing an age-dependent deceleration of cycles of fusion and fission, we observe a delay in the loss of average quality of mitochondria. This provides a rational why fusion and fission rates are reduced during aging and why loss of a mitochondrial fission factor can extend life span in fungi. We propose the 'mitochondrial infectious damage adaptation' (MIDA model according to which a deceleration of fusion-fission cycles reflects a systemic adaptation increasing life span.

  14. Slow and velocity-tunable beams of metastable He2 by multistage Zeeman deceleration

    Science.gov (United States)

    Motsch, Michael; Jansen, Paul; Agner, Josef A.; Schmutz, Hansjürg; Merkt, Frédéric

    2014-04-01

    We report on the use of multistage Zeeman deceleration to generate beams of He2 molecules in the metastable a3Σu+ state with velocities tunable down to 100 m/s. The metastable molecules are generated by striking a discharge in a supersonic expansion of pure helium gas from a pulsed valve held at cryogenic temperature. The velocity and internal-state distributions of the metastable He2 molecules are measured for nozzle temperatures of 300, 77, and 10 K by high-resolution photoelectron and photoionization spectroscopy. The deceleration process does not exhibit any rotational state selectivity with rotational levels up to N''=21 being populated, but eliminates molecules in spin-rotational sublevels with J''=N'' from the beam, where J'' and N'' are the total and the rotational angular momentum quantum number, respectively. The lack of rotational state selectivity is attributed to the fact that the Paschen-Back regime of the Zeeman effect in the rotational levels of He2 is already reached at fields of only 0.1 T.

  15. Player Load, Acceleration, and Deceleration During Forty-Five Competitive Matches of Elite Soccer.

    Science.gov (United States)

    Dalen, Terje; Ingebrigtsen, Jørgen; Ettema, Gertjan; Hjelde, Geir Havard; Wisløff, Ulrik

    2016-02-01

    The use of time-motion analysis has advanced our understanding of position-specific work rate profiles and the physical requirements of soccer players. Still, many of the typical soccer activities can be neglected, as these systems only examine activities measured by distance and speed variables. This study used triaxial accelerometer and time-motion analysis to obtain new knowledge about elite soccer players' match load. Furthermore, we determined acceleration/deceleration profiles of elite soccer players and their contribution to the players' match load. The data set includes every domestic home game (n = 45) covering 3 full seasons (2009, 2010, and 2011) for the participating team (Rosenborg FC), and includes 8 central defenders (n = 68), 9 fullbacks (n = 83), 9 central midfielders (n = 70), 7 wide midfielders (n = 39), and 5 attackers (A, n = 50). A novel finding was that accelerations contributed to 7-10% of the total player load for all player positions, whereas decelerations contributed to 5-7%. Furthermore, the results indicate that other activities besides the high-intensity movements contribute significantly to the players' total match workload. Therefore, motion analysis alone may underestimate player load because many high-intensity actions are without a change in location at the pitch or they are classified as low-speed activity according to current standards. This new knowledge may help coaches to better understand the different ways players achieve match load and could be used in developing individualized programs that better meet the "positional physical demands" in elite soccer.

  16. Decelerated invasion and waning moon patterns in public goods games with delayed distribution

    CERN Document Server

    Szolnoki, Attila

    2013-01-01

    We study the evolution of cooperation in the spatial public goods game, focusing on the effects that are brought about by the delayed distribution of goods that accumulate in groups due to the continuous investments of cooperators. We find that intermediate delays enhance network reciprocity because of a decelerated invasion of defectors, who are unable to reap the same high short-term benefits as they do in the absence of delayed distribution. Long delays, however, introduce a risk because the large accumulated wealth might fall into the wrong hands. Indeed, as soon as the curvature of a cooperative cluster turns negative, the engulfed defectors can collect the heritage of many generations of cooperators, and by doing so start a waning moon pattern that nullifies the benefits of decelerated invasion. Accidental meeting points of growing cooperative clusters may also act as triggers for the waning moon effect, thus linking the success of cooperators with their propensity to fail in a rather bizarre way. Our r...

  17. Collective effects and experimental verification of the CLIC drive beam and decelerator

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00418229; Stapnes, Steinar; Adli, Erik

    The Compact Linear Collider (CLIC) is a potential next-generation particle collider, in which electrons and positrons collide at a center-of-mass energy of up to 3 TeV. In order to reach a high accelerating gradient and reduce the length of the machine, CLIC uses a novel two-beam scheme. Here, the acceleration energy for the main beam is provided by energy extraction from a secondary electron drive beam, by the use of Power Extraction and Transfer Structures (PETS). This Ph.D. thesis describes deceleration measurements from the CLIC Test Facility 3 at CERN, from a beam that had up to 37 % of its kinetic energy converted into 12 GHz rf power. The results are part of the feasibility demonstration of the CLIC scheme. The measured difference in beam energy of the decelerated beam is correlated with particle tracking simulations and with predictions based on analytical formulae, and a very good agreement is demonstrated. The evolution of the transverse emittance was also studied, since it is critical to contain th...

  18. Energy recapture through deceleration - regenerative braking in electric vehicles from a user perspective.

    Science.gov (United States)

    Cocron, Peter; Bühler, Franziska; Franke, Thomas; Neumann, Isabel; Dielmann, Benno; Krems, Josef F

    2013-01-01

    We report results from a 1-year field study (N = 80) on user interactions with regenerative braking in electric vehicles. Designed to recapture energy in vehicles with electric powertrains, regenerative braking has an important influence on both the task of driving and energy consumption. Results from user assessments and data from onboard data loggers indicate that most drivers quickly learned to interact with the system, which was triggered via accelerator. Further, conventional braking manoeuvres decreased significantly as the majority of deceleration episodes could only be executed through regenerative braking. Still, some drivers reported difficulties when adapting to the system. These difficulties could be addressed by offering different levels of regeneration so that the intensity of the deceleration could be individually modified. In general, the system is trusted and regarded as a valuable tool for prolonging range. Regenerative braking in electric vehicles has direct implications for the driving task. We found that drivers quickly learn to use and accept a system, which is triggered via accelerator. For those reporting difficulties in the interaction, it appears reasonable to integrate options to customise or switch off the system.

  19. Cryogenic Current Comparator as Low Intensity Beam Current Monitor in the CERN Antiproton Decelerators

    CERN Document Server

    Fernandes, M; Soby, L; Welsch, CP

    2013-01-01

    In the low-energy Antiproton Decelerator (AD) and the future Extra Low ENergy Antiproton (ELENA) rings at CERN, an absolute measurement of the beam intensity is essential to monitor any losses during the deceleration and cooling phases. However, existing DC current transformers can hardly reach the μA level, while at the AD and ELENA currents can be as low as 100 nA. A Cryogenic Current Comparator (CCC) based on a superconducting quantum interference device (SQUID) is currently being designed and shall be installed in the AD and ELENA machines. It should meet the following specifications: A current resolution smaller than 10 nA, a dynamic range covering currents between 100 nA and 1 mA, as well as a bandwidth from DC to 1 kHz. Different design options are being considered, including the use of low or high temperature superconductor materials, different CCC shapes and dimensions, different SQUID characteristics, as well as electromagnetic shielding requirements. In this contribution we present first results f...

  20. Cassini Spacecraft Uncertainty Analysis Data and Methodology Review and Update/Volume 1: Updated Parameter Uncertainty Models for the Consequence Analysis

    Energy Technology Data Exchange (ETDEWEB)

    WHEELER, TIMOTHY A.; WYSS, GREGORY D.; HARPER, FREDERICK T.

    2000-11-01

    Uncertainty distributions for specific parameters of the Cassini General Purpose Heat Source Radioisotope Thermoelectric Generator (GPHS-RTG) Final Safety Analysis Report consequence risk analysis were revised and updated. The revisions and updates were done for all consequence parameters for which relevant information exists from the joint project on Probabilistic Accident Consequence Uncertainty Analysis by the United States Nuclear Regulatory Commission and the Commission of European Communities.

  1. Anisotropic string cosmological model in Brans–Dicke theory of gravitation with time-dependent deceleration parameter

    Energy Technology Data Exchange (ETDEWEB)

    Maurya, D. Ch., E-mail: dcmaurya563@gmail.com; Zia, R., E-mail: rashidzya@gmail.com; Pradhan, A., E-mail: pradhan.anirudh@gmail.com [GLA University, Department of Mathematics, Institute of Applied Sciences and Humanities (India)

    2016-10-15

    We discuss a spatially homogeneous and anisotropic string cosmological models in the Brans–Dicke theory of gravitation. For a spatially homogeneous metric, it is assumed that the expansion scalar θ is proportional to the shear scalar σ. This condition leads to A = kB{sup m}, where k and m are constants. With these assumptions and also assuming a variable scale factor a = a(t), we find solutions of the Brans–Dicke field equations. Various phenomena like the Big Bang, expanding universe, and shift from anisotropy to isotropy are observed in the model. It can also be seen that in early stage of the evolution of the universe, strings dominate over particles, whereas the universe is dominated by massive strings at the late time. Some physical and geometrical behaviors of the models are also discussed and observed to be in good agreement with the recent observations of SNe la supernovae.

  2. Velocity-tunable slow beams of cold O2 in a single spin-rovibronic state with full angular-momentum orientation by multistage Zeeman deceleration

    Science.gov (United States)

    Wiederkehr, A. W.; Schmutz, H.; Motsch, M.; Merkt, F.

    2012-08-01

    Cold samples of oxygen molecules in supersonic beams have been decelerated from initial velocities of 390 and 450 m s-1 to final velocities in the range between 150 and 280 m s-1 using a 90-stage Zeeman decelerator. (2 + 1) resonance-enhanced-multiphoton-ionization (REMPI) spectra of the 3sσ g 3Π g (C) ? two-photon transition of O2 have been recorded to characterize the state selectivity of the deceleration process. The decelerated molecular sample was found to consist exclusively of molecules in the J ‧‧ = 2 spin-rotational component of the X ? ground state of O2. Measurements of the REMPI spectra using linearly polarized laser radiation with polarization vector parallel to the decelerator axis, and thus to the magnetic-field vector of the deceleration solenoids, further showed that only the ? magnetic sublevel of the N‧‧ = 1, J ‧‧ = 2 spin-rotational level is populated in the decelerated sample, which therefore is characterized by a fully oriented total-angular-momentum vector. By maintaining a weak quantization magnetic field beyond the decelerator, the polarization of the sample could be maintained over the 5 cm distance separating the last deceleration solenoid and the detection region.

  3. Fermion fields in Einstein-Cartan theory and the accelerated-decelerated transition in a primordial Universe

    CERN Document Server

    Ribas, Marlos O

    2009-01-01

    In this work the accelerated-decelerated transition in a primordial Universe is investigated by using the dynamics of fermion fields within the context of Einstein-Cartan theory, where apart from the curvature the space-time is also described by a torsion field. The model analyzed here has only a fermion field as the source of the gravitational field. The term associated with the spin of the fermion field plays the role of the inflaton which contributes to an accelerated regime whereas the one related to the fermion mass behaves as a matter field and is the responsible for a decelerated regime. Hence, by taking into account the spin of a massive fermion field it is possible to characterize the transition from the accelerated to the decelerated periods of the primordial Universe.

  4. Evaluation of dose-volume histogram parameters (V20 and mean dose) in lung cancer adaptive radiotherapy with design of composite lung volumes (ITV; Evaluacion de parametros del histograma dosis-volumen (V20 y dosis media) en radioterapia adaptada de cancer de pulmon con diseno de volumenes pulmonares compuestos (Internal Target Volume, ITV)

    Energy Technology Data Exchange (ETDEWEB)

    Monroy Anton, J. L.; Solar Tortosa, M.; Lopez Munoz, M.; Navarro Bergada, A.; Estornell gualde, M. A.; Melchor Iniguez, M.

    2013-07-01

    Physiological respiratory motion is a challenge in external radiotherapy for lung tumors. In adaptive radiotherapy, changing position of the target volume should be reflected in the simulation procedure and taken into account in the design of volumes for CTV/PTV proper coverage. This may be achieved through the design of an Internal Target Volume (ITV) as indicated in ICRU-62. However, the Dose-Volume Histogram (DVH) evaluation of the doses received by the healthy lung may vary in the case of designing a single lung volume, compared to the composite lung volume obtained with the fusion of normal breathing, inspiration and expiration (ITV{sub l}ung). (Author)

  5. Cardiac function after chemoradiation for esophageal cancer: comparison of heart dose-volume histogram parameters to multiple gated acquisition scan changes.

    Science.gov (United States)

    Tripp, P; Malhotra, H K; Javle, M; Shaukat, A; Russo, R; De Boer, S; Podgorsak, M; Nava, H; Yang, G Y

    2005-01-01

    In this paper we determine if preoperative chemoradiation for locally advanced esophageal cancer leads to changes in cardiac ejection fraction. This is a retrospective review of 20 patients treated at our institution for esophageal cancer between 2000 and 2002. Multiple gated acquisition cardiac scans were obtained before and after platinum-based chemoradiation (50.4 Gy). Dose-volume histograms for heart, left ventricle and left anterior descending artery were analyzed. Outcomes assessed included pre- and postchemoradiation ejection fraction ratio and percentage change in ejection fraction postchemoradiation. A statistically significant difference was found between median prechemoradiation ejection fraction (59%) and postchemoradiation ejection fraction (54%) (P = 0.01), but the magnitude of the difference was not clinically significant. Median percentage volume of heart receiving more than 20, 30 and 40 Gy were 61.5%, 58.5% and 53.5%, respectively. Our data showed a clinically insignificant decline in ejection fraction following chemoradiation for esophageal cancer. We did not observe statistically or clinically significant associations between radiation dose to heart, left ventricle or left anterior descending artery and postchemoradiation ejection fraction.

  6. Accelerating and decelerating cosmology from spinor and scalar fields non-minimally coupled with f(R) gravity

    CERN Document Server

    Rybalov, Yu A; Osetrin, K E

    2014-01-01

    In this paper we investigate the accelerating and decelerating cosmological models with non-linear spinor fields and non-minimal interaction of $f(R)$ gravity with a scalar field. We combine two different approaches to the description of dark energy: modified gravity theory and introduction of the additional fields. Solutions for the FRW universe with power-law scale factor are reconstructed for the model under consideration with specific choice for scalar and spinor potentials. It is explained the role of scalar and spinor potentials as well as f(R) function for emergence of accelerating or decelerating cosmology.

  7. Compact disposal of high-energy electron beams using passive or laser-driven plasma decelerating stage

    Energy Technology Data Exchange (ETDEWEB)

    Bonatto, A.; Schroeder, C. B.; Vay, J. -L.; Geddes, C. R.; Benedetti, C.; Esarey and, E.; Leemans, W. P.

    2014-07-13

    A plasma decelerating stage is investigated as a compact alternative for the disposal of high-energy beams (beam dumps). This could benefit the design of laser-driven plasma accelerator (LPA) applications that require transportability and or high-repetition-rate operation regimes. Passive and laser-driven (active) plasma-based beam dumps are studied analytically and with particle-in-cell (PIC) simulations in a 1D geometry. Analytical estimates for the beam energy loss are compared to and extended by the PIC simulations, showing that with the proposed schemes a beam can be efficiently decelerated in a centimeter-scale distance.

  8. Design and Execution of the Hypersonic Inflatable Aerodynamic Decelerator Large-Article Wind Tunnel Experiment

    Science.gov (United States)

    Cassell, Alan M.

    2013-01-01

    The testing of 3- and 6-meter diameter Hypersonic Inflatable Aerodynamic Decelerator (HIAD) test articles was completed in the National Full-Scale Aerodynamics Complex 40 ft x 80 ft Wind Tunnel test section. Both models were stacked tori, constructed as 60 degree half-angle sphere cones. The 3-meter HIAD was tested in two configurations. The first 3-meter configuration utilized an instrumented flexible aerodynamic skin covering the inflatable aeroshell surface, while the second configuration employed a flight-like flexible thermal protection system. The 6-meter HIAD was tested in two structural configurations (with and without an aft-mounted stiffening torus near the shoulder), both utilizing an instrumented aerodynamic skin.

  9. The effect of the acceleration/deceleration trauma in angioid streaks: A pathogenic hypothesis.

    Science.gov (United States)

    Fajardo Sánchez, J; Chau Ramos, C E; Mazagatos Used, P J; Aparicio Hernandez-Lastras, M J

    2016-09-01

    A 59-year-old male with acceleration/deceleration cranial trauma (ADT), caused by a car accident. After one month, he presented with loss of visual acuity in the right eye. A fluorescein angiography test was performed and it detected centrifugal hyperfluorescent lines from the optic nerve head, a characteristic compatible with the diagnosis of angioid streaks. The loss of visual acuity was demonstrated by the discovery of a juxtafoveal choroidal neovascular membrane (CNV). ADT can cause hyper-extension of the eyeball in its equator line, producing the rupture of fragile structures such as the Bruch membrane (MB) in patients with angioid streaks and the subsequent formation of CNV. Copyright © 2016 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

  10. Prognostic importance of a short deceleration time in symptomatic congestive heart failure

    DEFF Research Database (Denmark)

    Akkan, Dilek; Kjaergaard, Jesper; Møller, Jacob Eifer

    2008-01-01

    AIMS: A restrictive transmitral filling (RF) pattern predicts increased mortality in heart failure (HF) with reduced left ventricular (LV) systolic function. We performed a combined evaluation of LV function and RF for prognosis in patients with HF with and without systolic dysfunction. METHODS...... AND RESULTS: Doppler echocardiography was performed in 972 patients with symptomatic HF. RF was considered present when deceleration time (DT) was 140 ms. A DT >240 ms was defined as delayed relaxation. During a median of 51 months the unadjusted all-cause mortality rates were significantly increased among...... patients with RF vs. the non-RF group (1- and 4-year mortality was 25% and 54% vs. 17% and 43%). In a multivariable model, RF was a significant predictor of all-cause mortality (hazard ratio (HR)=2.0, 95% confidence interval (CI):1.5-2.6) whereas delayed relaxation was without prognostic importance (HR=0...

  11. From catastrophic acceleration to deceleration of liquid plugs in prewetted capillary tubes

    CERN Document Server

    Magniez, J C; Liu, C; Zoueshtiagh, F

    2016-01-01

    The dynamics of individual liquid plugs pushed at constant pressure head inside prewetted cylindrical capillary tubes is investigated experimentally and theoretically. It is shown that, depending on the thickness of the prewetting film and the magnitude of the pressure head, the plugs can either experience a continuous acceler ation leading to a catastrophic decrease of their size and eventually their rupture or conversely, a progressive deceleration associated with their growth. These behaviors are quantitatively reproduced with a simple nonlinear model [Baudoin et al., Proc. Nat. Ac. Sci. USA, 2013, 110, 859] adapted here for cylindrical channels. Furthermore, an analytical criterion for the transition between these two regimes is obtained and successfully compared with extensive experimental data. The implications of this work for pulmonary obstructive diseases are discussed.

  12. Mechanically-Deployed Hypersonic Decelerator and Conformal Ablator Technologies for Mars Missions

    Science.gov (United States)

    Venkatapathy, Ethiraj; Wercinski, Paul F.; Beck, Robin A. S.; Hamm, Kenneth R.; Yount, Bryan C.; Makino, A.; Smith, B.; Gage, P.; Prabhu, D.

    2012-01-01

    The concept of a mechanically deployable hypersonic decelerator, developed initially for high mass (40 MT) human Mars missions, is currently funded by OCT for technology maturation. The ADEPT (Adaptive, Deployable Entry and Placement Technology) project has broad, game-changing applicability to in situ science missions to Venus, Mars, and the Outer Planets. Combined with maturation of conformal ablator technology (another current OCT investment), the two technologies provide unique low mass mission enabling capabilities otherwise not achievable by current rigid aeroshell or by inflatables. If this abstract is accepted, we will present results that illustrate the mission enabling capabilities of the mechanically deployable architecture for: (1) robotic Mars (Discovery or New Frontiers class) in the near term; (2) alternate approaches to landing MSL-class payloads, without the need for supersonic parachute or lifting entry, in the mid-term; and (3) Heavy mass and human missions to Mars in the long term.

  13. Theoretical studies of electrostatic Stark deceleration for subsonic NH3 molecular b eams%亚声速NH3分子束静电Stark减速的理论研究∗

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    In this paper, we investigate theoretically the Stark deceleration and cooling of subsonic NH3 molecular beams based on our second-generation electrostatic Stark decelerator with 180 stages. Firstly, we calculate the Stark shifts of NH3 molecules in the|J =1, K =1⟩states and show the stable area of longitudinal phase space for different synchronous phase angles. Secondly, we study the slowing performance of NH3 molecular beams in the traditional mode, and discuss the relationships between various parameters (such as the kinetic energy loss per stage, final velocity and the slowing efficiency) and the synchronous phase angle ϕ0, as well as the dependence of final velocity on the applied voltages. It is found that a subsonic NH3 molecular beam can be decelerated from 280 to 6.7 m/s at ϕ0 = 26.08◦ when the high voltages applied on the electrodes are ±13 kV, corresponding to a removal of 99.9% kinetic energy. The translational temperature of the molecular packets in the moving frame is significantly reduced from 1.34 K to 80 mK. Finally, we study the slowing performance of NH3 molecules and the dependence of final velocity on the synchronous phase angle in an alternate operation mode. In this mode, a synchronous phase angleϕ0=0◦is chosen to bunch the molecules by using the first 15 stages. The remaining 165 stages are then used to slow a subsonic molecular beam at a certain synchronous phase angle. Our result shows that a molecular beam with a mean velocity of 280 m/s can be decelerated to 20.7 m/s at ϕ0 =65.4◦ when the voltages applied are ±6.5 kV, indicating a 99.4% kinetic energy removal, and the translational temperature of the molecular packets can be reduced from 1.34 K to 1.6 mK. By comparing the results obtained from the two operational modes, the temperature of the slowed molecular packet in the alternate mode is 50 times lower than that in the traditional mode. It is shown that our second-generation 180-stage Stark decelerator can effectively

  14. Influence of T-semi attached rib on turbulent flow and heat transfer parameters of a silver-water nanofluid with different volume fractions in a three-dimensional trapezoidal microchannel

    Science.gov (United States)

    Alipour, Habibollah; Karimipour, Arash; Safaei, Mohammad Reza; Semiromi, Davood Toghraie; Akbari, Omid Ali

    2017-04-01

    This study aimed at exploring influence of T-semi attached rib on the turbulent flow and heat transfer parameters of a silver-water nanofluid with different volume fractions in a three-dimensional trapezoidal microchannel. For this purpose, convection heat transfer of the silver-water nanofluid in a ribbed microchannel was numerically studied under a constant heat flux on upper and lower walls as well as isolated side walls. Calculations were done for a range of Reynolds numbers between 10,000 and 16,000, and in four different sorts of serrations with proportion of rib width to hole of serration width (R/W). The results of this research are presented as the coefficient of friction, Nusselt number, heat transfer coefficient and thermal efficiency, four different R/W microchannels. The results of numerical modeling showed that the fluid's convection heat transfer coefficient is increased as the Reynolds number and volume fraction of solid nanoparticle are increased. For R/W=0.5, it was also maximum for all the volume fractions of nanoparticle and different Reynolds numbers in comparison to other similar R/W situations. That's while friction coefficient, pressure drop and pumping power is maximum for serration with R/W=0 compared to other serration ratios which lead to decreased fluid-heat transfer performance.

  15. Faranoff-Riley type I jet deceleration at density discontinuities Relativistic hydrodynamics with a realistic equation of state

    NARCIS (Netherlands)

    Meliani, Z.; Keppens, R.; Giacomazzo, B.

    2008-01-01

    Aims. We propose a model that could explain the sudden jet deceleration in active galactic nuclei, thereby invoking density discontinuities. Motivated particularly by recent indications from HYbrid MOrphology Radio Sources (HYMORS) that Fanaroff-Riley classification is induced in some cases by varia

  16. Deceleration of MeV antiprotons and muons to keV energies — the anticyclotron A progress report

    Science.gov (United States)

    Horváth, D.; Aschenauer, E. C.; Cauz, D.; Chatellard, D.; DeCecco, P.; Eades, J.; Egger, J.-P.; Elsener, K.; Eugster, P.; Formisano, F.; Gorini, G.; Hauser, P.; Kottmann, F.; Krafcsik, I.; Lagomarsino, V.; Manuzio, G.; Missimer, J.; Poggiani, R.; Simons, L. M.; Testera, G.; Torelli, G.; Waldner, F.

    1994-03-01

    A progress report is presented on the development of the anticyclotron — deceleration of antiprotons and negative muons via collisions in a low-pressure gas or thin foils during revolutions in a cyclotron field. Beam tests performed at CERN and PSI are reported and future plans for applications outlined.

  17. Deceleration of MeV antiprotons and muons to keV energies - the anticyclotron. A progress report

    Energy Technology Data Exchange (ETDEWEB)

    Horvath, D.; Aschenauer, E.C.; Cauz, D.; Chatellard, D.; DeCecco, P.; Eades, J.; Egger, J.P.; Elsener, K.; Eugster, P.; Formisano, F.; Gorini, G.; Hauser, P.; Kottmann, F.; Krafcsik, I.; Lagomarsino, V.; Manuzio, G.; Missimer, J.; Poggiani, R.; Simons, L.M.; Testera, G.; Torelli, G.; Waldner, F. (KFKI Research Inst. for Particle and Nuclear Physics, Budapest (Hungary) Pisa Univ. (Italy) INFN, Pisa (Italy) Paul Scherrer Inst., Villigen (Switzerland) Univ. di Udine (Italy) Neuchatel Univ. (Switzerland) CERN, Geneva (Switzerland) ETH Zuerich, Villigen (Switzerland) KFKI Research Inst. for Materials Science, Budapest (Hungary) Genova Univ. (Italy) INFN, Genova (Italy))

    1994-03-01

    A progress report is presented on the development of the anticyclotron - deceleration of antiprotons and negative muons via collisions in a low-pressure gas or thin foils during revolutions in a cyclotron field. Beam tests performed at CERN and PSI are reported and future plans for applications outlined. (orig.)

  18. Faranoff-Riley type I jet deceleration at density discontinuities Relativistic hydrodynamics with a realistic equation of state

    NARCIS (Netherlands)

    Meliani, Z.; Keppens, R.; Giacomazzo, B.

    2008-01-01

    Aims. We propose a model that could explain the sudden jet deceleration in active galactic nuclei, thereby invoking density discontinuities. Motivated particularly by recent indications from HYbrid MOrphology Radio Sources (HYMORS) that Fanaroff-Riley classification is induced in some cases by

  19. Dr. Hirotaka Sugawara, Director General of Japan's high energy physics laboratory, KEK, visited the Antiproton Decelerator, AD

    CERN Multimedia

    Laurent Guiraud

    2001-01-01

    L. to r.: Masaki Hori, member of the ASACUSA collaboration, John Eades, contact person for ASACUSA, Dr. Hirotaka Sugawara, Werner Pirkl, the PS Division engineer responsible for the Radio Frequency Quadrupole decelerator in the foreground, and Kurt H bner, CERN's Director of Accelerators

  20. Volume-Based Parameters of {sup 18}F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Improve Disease Recurrence Prediction in Postmastectomy Breast Cancer Patients With 1 to 3 Positive Axillary Lymph Nodes

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, Naomi, E-mail: haruhi0321@gmail.com [Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Department of Radiology, Ehime University, Ehime (Japan); Kataoka, Masaaki [Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Sugawara, Yoshifumi [Department of Diagnostic Radiology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Ochi, Takashi [Department of Radiology, Ehime University, Ehime (Japan); Kiyoto, Sachiko; Ohsumi, Shozo [Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Mochizuki, Teruhito [Department of Radiology, Ehime University, Ehime (Japan)

    2013-11-15

    Purpose: To determine whether volume-based parameters on pretreatment {sup 18}F-fluorodeoxyglucose positron emission tomography/computed tomography in breast cancer patients treated with mastectomy without adjuvant radiation therapy are predictive of recurrence. Methods and Materials: We retrospectively analyzed 93 patients with 1 to 3 positive axillary nodes after surgery, who were studied with {sup 18}F-fluorodeoxyglucose positron emission tomography/computed tomography for initial staging. We evaluated the relationship between positron emission tomography parameters, including the maximum standardized uptake value, metabolic tumor volume (MTV), and total lesion glycolysis (TLG), and clinical outcomes. Results: The median follow-up duration was 45 months. Recurrence was observed in 11 patients. Metabolic tumor volume and TLG were significantly related to tumor size, number of involved nodes, nodal ratio, nuclear grade, estrogen receptor (ER) status, and triple negativity (TN) (all P values were <.05). In receiver operating characteristic curve analysis, MTV and TLG showed better predictive performance than tumor size, ER status, or TN (area under the curve: 0.85, 0.86, 0.79, 0.74, and 0.74, respectively). On multivariate analysis, MTV was an independent prognostic factor of locoregional recurrence-free survival (hazard ratio 34.42, 95% confidence interval 3.94-882.71, P=.0008) and disease-free survival (DFS) (hazard ratio 13.92, 95% confidence interval 2.65-103.78, P=.0018). The 3-year DFS rate was 93.8% for the lower MTV group (<53.1; n=85) and 25.0% for the higher MTV group (≥53.1; n=8; P<.0001, log–rank test). The 3-year DFS rate for patients with both ER-positive status and MTV <53.1 was 98.2%; and for those with ER-negative status and MTV ≥53.1 it was 25.0% (P<.0001). Conclusions: Volume-based parameters improve recurrence prediction in postmastectomy breast cancer patients with 1 to 3 positive nodes. The addition of MTV to ER status or TN has

  1. Establishment of minimum operational parameters for a high-volume static chamber steam pasteurization system (SPS 400-SC) for beef carcasses to support HACCP programs.

    Science.gov (United States)

    Retzlaff, Deanna; Phebus, Randall; Kastner, Curtis; Marsden, James

    2005-01-01

    A static chamber steam pasteurization unit (SPS 400-SC()) was installed in a high-volume commercial beef slaughter facility. The SPS 400-SC consists of a three-phase carcass treatment cycle of water removal, steam pasteurization, and water chilling. Seven chamber temperatures (71.1, 73.9, 76.7, 79.4, 82.2, 85.0, and 87.8 degrees C) were evaluated at the midline area of pre-rigor beef carcasses. For each temperature evaluated, 20 carcass sides were randomly selected and aseptically sampled by tissue excision immediately before and after steam pasteurization to determine total aerobic bacteria, Enterobacteriaceae, generic E. coli, and total coliform populations. The 87.8 and 85.0 degrees C treatment temperatures were highly effective at reducing total aerobic bacterial populations, with log(10) reductions of 1.4 and 1.5 CFU/cm(2), respectively, from pretreatment mean population levels of 1.7 and 1.9 log10 CFU/cm(2). These temperatures also reduced Enterobacteriaceae, total coliforms, and generic E. coli to undetectable levels (HACCP)-based system employing steam pasteurization of carcasses as a critical control point, a critical limit of 85.0 degrees C as a minimum chamber temperature should be established, with a targeted operating temperature of 87.8 degrees C providing optimum antimicrobial activity.

  2. Injury rates in martial art athletes: anthropometric parameters and training volume, but not foot morphology indexes, are predictive risk factors for lower limb injuries.

    Science.gov (United States)

    Vitale, Jacopo A; Bassani, Tito; Galbusera, Fabio; Bianchi, Alberto; Martinelli, Nicolò

    2017-09-22

    Previous studies attempted to identify possible risk factors for acute and overuse injuries in several sports disciplines such as running, gymnastics or team sports. Given the lack of scientific works focused on risk factors for lower limb injuries in martial arts, the present study was aimed to investigate foot anatomy, anthropometric measures, and other background information as possible risk factors of injury in barefoot athletes practicing judo, karate, kung fu, thai boxe, or aikido. In addition, the injury rates were evaluated in relation with the different martial art styles. One group of 130 martial artists was retrospectively evaluated. Data of three foot morphological variables were collected: navicular height (NH), navicular drop (ND) and the rear foot (RF). In addition, each participant filled an interview questionnaire providing the following information: age, sex, body weight, height, BMI, hours of training per week, the kind of injury occurred to the lower limbs in the preceding year. Of 130 subjects, 70 (53.8%) did not sustain injuries, 35 (27.0%) suffered an acute injury and the remaining 25 (19.2%) reported an overuse injury. No significant differences were observed in the injury rates in relation to style and kind of martial art. Age, training volume and BMI were found as significant predictors of injury, while NH, ND and RF were not able to predict acute or overuse injury at lower limbs. The injury rates were similar in karate, judo, kung fu, aikido, and thai boxe. The foot morphology variables were not related with the presence or absence of acute and overuse injuries. Conversely, older and heavier martial artists, performing more hours of barefoot training, are at higher risk of acute and overuse injury. Athletic trainers should strongly take into account the present information in order to develop more accurate and specific injury prevention programs for martial artists.

  3. LLE Review Quarterly Report (October-December 2000). Volume 85

    Energy Technology Data Exchange (ETDEWEB)

    Sources, John M. [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

    2000-12-01

    This volume of the LLE Review, covering October-December 2000, begins with an article by R. Betti, M. Umansky, V. Lobatchev, V. N. Goncharov, and R. L. McCrory, who report on the development of a model for the deceleration phase of an imploding inertial fusion capsule (p. 1). The model shows that the ablative flow off the inner shell surface plays a critical role in reducing the growth rate and suppressing short-wavelength modes in the deceleration-phase Rayleigh-Taylor instability. Other articles in this volume are: The Effect of Shock Heating on the Stability of Laser-Driven Targets; Spherical Cavity Expansion in Material with Densification; Design and Performance of a Selectable-Rate Streak-Camera Deflection Ramp Generator; Unique High-Bandwidth, UV Fiber Deliver System for OMEGA Diagnostics Applications; Fabrication and Properties of an Ultrafast NbN Hot-Electron Single-Photon detector; and, Preliminary Design of NIF 2-D SSD.

  4. Prognostic significance of sinus deceleration during dobutamine stress echocardiography test following acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Šalinger Sonja

    2006-01-01

    Full Text Available Background/Aim. Chronotropic incompetence during exercise stress testing after acute myocardial infarction is an indicator of ischemia or impaired left ventricular function. On the other side, infusion of dobutamine leads to a typical dose-dependent increase in heart rate. The aim of this study was to evaluate of paradoxical sinus deceleration during dobutamine stress echocardiography (DSE, as the sign of ischemia and impaired left ventricular function, or the consequence of infarction localization, and the estimation of prognostic significance after acute myocardial infarction. Methods. Our investigation comprised 81 patients hospitalized because of the acute myocardial infarction, and all of them had uncomplicated infarction. Fifty five patients were treated with thrombolytic therapy (67.9%; 53 patients (65.4% had anterior myocardial infarction, and 28 patients (34.6% had inferoposterior localization of myocardial infarction. After 10-12 days all of them underwent dobutamine stress echocardiography examination. During the next 3-6 months, the patients underwent coronary angiography. The average follow-up period was 36±22 months. Results. A decrease in heart rate occurred at the dobutamine doses increasing from 15-40mcg/kg/min in 9 (11.1% of the patients, in 1 patient with an anterior localization and in 8 patients with an inferoposterior localization. The decrease was sudden in 4 (44.4%, and gradual in 5 (55.6% of the patients. In 3 patients (33.3% junction rhythm was developed, and in 2 patients (22.2% AV block II-III. Only in 2 of them, there was a worsening of regional function during a high dose dobutamine infusion, but 7 of them showed an improvement during a low dose. In 7 (77.8% of the patients there was a simultaneous decrease in blood pressure. Coronary angiographic examination showed that in 4 (44.4% of the patients there was a significant coronary artery disease and they underwent the revascularization procedure. During the follow

  5. Coherent structures in a zero-pressure-gradient and a strongly decelerated boundary layer

    Science.gov (United States)

    Simens, Mark P.; Gungor, Ayse G.; Maciel, Yvan

    2016-04-01

    Coherent structures in a strongly decelerated large-velocity-defect turbulent boundary layer (TBL) and a zero pressure gradient (ZPG) boundary layer are analysed by direct numerical simulation (DNS). The characteristics of the one-point velocity stastistics are also considered. The adverse pressure gradient (APG) TBL simulation is a new one carried out by the present authors. The APG TBL begins as a zero pressure gradient boundary layer, decelerates under a strong adverse pressure gradient, and separates near the end of the domain in the form of a very thin separation bubble. The one-point velocity statistics in the outer region of this large-defect boundary layer are compared to those of two other large-velocity-defect APG TBLs (one in dynamic equilibrium, the other in disequilibrium) and a mixing layer. In the upper half of the large-defect boundary layers, the velocity statistics are similar to those of the mixing layer. The dominant peaks of turbulence production and Reynolds stresses are located in the middle of the boundary layers. Three-dimensional spatial correlations of (u, u) and (u, v) show that coherence is lost in the streamwise and spanwise directions as the velocity defect increases. Near-wall streaks tend to disappear in the large-defect zone of the flow to be replaced by more disorganized u motions. Near-wall sweeps and ejections are also less numerous. In the outer region, the u structures tend to be shorter, less streaky, and more inclined with respect to the wall than in the ZPG TBL. The sweeps and ejections are generally bigger with respect to the boundary layer thickness in the large-defect boundary layer, even if the biggest structures are found in the ZPG TBL. Large sweeps and ejections that reach the wall region (wall-attached) are less streamwise elongated and they occupy less space than in the ZPG boundary layer. The distinction between wall-attached and wall-detached structures is not as pronounced in the large-defect TBL.

  6. On the accuracy of estimation of basic pharmacokinetic parameters by the traditional noncompartmental equations and the prediction of the steady-state volume of distribution in obese patients based upon data derived from normal subjects.

    Science.gov (United States)

    Berezhkovskiy, Leonid M

    2011-06-01

    The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V(ss), V(β), and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C(p) (t) following intravenous (i.v. bolus or constant rate infusion) drug administration. These calculations are valid for the linear pharmacokinetic system with central elimination (i.e., elimination rate being proportional to drug concentration in plasma). Formally, the assumption of central elimination is not normally met because the rate of drug elimination is proportional to the unbound drug concentration at elimination site, although equilibration between systemic circulation and the site of clearance for majority of small molecule drugs is fast. Thus, the assumption of central elimination is practically quite adequate. It appears reasonable to estimate the extent of possible errors in determination of these pharmacokinetic parameters due to the absence of central elimination. The comparison of V(ss), V(β), and MRT calculated by exact equations and the commonly used ones was made considering a simplified physiologically based pharmacokinetic model. It was found that if the drug plasma concentration profile is detected accurately, determination of drug distribution volumes and MRT using the traditional noncompartmental calculations of these parameters from C(p) (t) yields the values very close to that obtained from exact equations. Though in practice, the accurate measurement of C(p) (t), especially its terminal phase, may not always be possible. This is particularly applicable for obtaining the distribution volumes of lipophilic compounds in obese subjects, when the possibility of late terminal phase at low drug concentration is quite likely, specifically for compounds with high clearance. An accurate determination of V(ss) is much needed in clinical practice because it is critical for the proper selection of drug treatment

  7. Thermal Design and Analysis of the Supersonic Flight Dynamics Test Vehicle for the Low Density Supersonic Decelerator Project

    Science.gov (United States)

    Mastropietro, A. J.; Pauken, Michael; Sunada, Eric; Gray, Sandria

    2013-01-01

    The thermal design and analysis of the experimental Supersonic Flight Dynamics Test (SFDT) vehicle is presented. The SFDT vehicle is currently being designed as a platform to help demonstrate key technologies for NASA's Low Density Supersonic Decelerator (LDSD) project. The LDSD project is charged by NASA's Office of the Chief Technologist (OCT) with the task of advancing the state of the art in Mars Entry, Descent, and Landing (EDL) systems by developing and testing three new technologies required for landing heavier payloads on Mars. The enabling technologies under development consist of a large 33.5 meter diameter Supersonic Ringsail (SSRS) parachute and two different types of Supersonic Inflatable Aerodynamic Decelerator (SIAD) devices - a robotic class, SIAD-R, that inflates to a 6 meter diameter torus, and an exploration class, SIAD-E, that inflates to an 8 meter diameter isotensoid. As part of the technology development effort, the various elements of the new supersonic decelerator system must be tested in a Mars-like environment. This is currently planned to be accomplished by sending a series of SFDT vehicles into Earth's stratosphere. Each SFDT vehicle will be lifted to a stable float altitude by a large helium carrier balloon. Once at altitude, the SFDT vehicles will be released from their carrier balloon and spun up via spin motors to provide trajectory stability. An onboard third stage solid rocket motor will propel each test vehicle to supersonic flight in the upper atmosphere. After main engine burnout, each vehicle will be despun and testing of the deceleration system will begin: first an inflatable decelerator will be deployed around the aeroshell to increase the drag surface area, and then the large parachute will be deployed to continue the deceleration and return the vehicle back to the Earth's surface. The SFDT vehicle thermal system must passively protect the vehicle structure and its components from cold temperatures experienced during the

  8. The Research of Car-Following Model Based on Real-Time Maximum Deceleration

    Directory of Open Access Journals (Sweden)

    Longhai Yang

    2015-01-01

    Full Text Available This paper is concerned with the effect of real-time maximum deceleration in car-following. The real-time maximum acceleration is estimated with vehicle dynamics. It is known that an intelligent driver model (IDM can control adaptive cruise control (ACC well. The disadvantages of IDM at high and constant speed are analyzed. A new car-following model which is applied to ACC is established accordingly to modify the desired minimum gap and structure of the IDM. We simulated the new car-following model and IDM under two different kinds of road conditions. In the first, the vehicles drive on a single road, taking dry asphalt road as the example in this paper. In the second, vehicles drive onto a different road, and this paper analyzed the situation in which vehicles drive from a dry asphalt road onto an icy road. From the simulation, we found that the new car-following model can not only ensure driving security and comfort but also control the steady driving of the vehicle with a smaller time headway than IDM.

  9. Look-Ahead Algorithm with Whole S-Curve Acceleration and Deceleration

    Directory of Open Access Journals (Sweden)

    Youdong Chen

    2013-01-01

    Full Text Available Tool paths of a complex contour machining generated by commercial CAD/CAM systems are mainly composed of many short linear/circular blocks. Though the look-ahead algorithms can improve speed and accuracy in the machining of short linear/circular segments, most of them just deal with linear segments with trapezoid acceleration and deceleration (acc/dec. In addition, the look-ahead algorithms with S-curve acc/dec are too complex to adopt the equivalent S-curve profile by approximation algorithm. To increase the smoothness of feedrate profile and machining efficiency of continuous short line and circle machining, this paper presents a feedrate profile generation approach and corresponding look-ahead algorithm with whole S-curve acc/dec. With the proposed look-ahead scheme, the feedrate profiles with S-curve acc/dec can work efficiently in a lot of short line and circle segments. Thus, the machining productivity can be increased and the feedrate profiles are smooth. The simulation and experiments verify the feasibility and validity of the proposed approach.

  10. Three-Dimensional Simulations of the Deceleration Phase of Inertial Fusion Implosions

    Science.gov (United States)

    Woo, K. M.; Betti, R.; Bose, A.; Epstein, R.; Delettrez, J. A.; Anderson, K. S.; Yan, R.; Chang, P.-Y.; Jonathan, D.; Charissis, M.

    2015-11-01

    The three-dimensional radiation-hydrodynamics code DEC3D has been developed to model the deceleration phase of direct-drive inertial confinement fusion implosions. The code uses the approximate Riemann solver on a moving mesh to achieve high resolution near discontinuities. The domain decomposition parallelization strategy is implemented to maintain high computation efficiency for the 3-D calculation through message passing interface. The implicit thermal diffusion is solved by the parallel successive-over-relaxation iteration. Results from 3-D simulations of low-mode Rayleigh-Taylor instability are presented and compared with 2-D results. A systematic comparison of yields, pressures, temperatures, and areal densities between 2-D and 3-D is carried out to determine the additional degradation in target performance caused by the three-dimensionality of the nonuniformities. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944 and DE-FC02-04ER54789 (Fusion Science Center).

  11. A charge coupled device camera with electron decelerator for intermediate voltage electron microscopy.

    Science.gov (United States)

    Downing, Kenneth H; Mooney, Paul E

    2008-04-01

    Electron microscopists are increasingly turning to intermediate voltage electron microscopes (IVEMs) operating at 300-400 kV for a wide range of studies. They are also increasingly taking advantage of slow-scan charge coupled device (CCD) cameras, which have become widely used on electron microscopes. Under some conditions, CCDs provide an improvement in data quality over photographic film, as well as the many advantages of direct digital readout. However, CCD performance is seriously degraded on IVEMs compared to the more conventional 100 kV microscopes. In order to increase the efficiency and quality of data recording on IVEMs, we have developed a CCD camera system in which the electrons are decelerated to below 100 kV before impacting the camera, resulting in greatly improved performance in both signal quality and resolution compared to other CCDs used in electron microscopy. These improvements will allow high-quality image and diffraction data to be collected directly with the CCD, enabling improvements in data collection for applications including high-resolution electron crystallography, single particle reconstruction of protein structures, tomographic studies of cell ultrastructure, and remote microscope operation. This approach will enable us to use even larger format CCD chips that are being developed with smaller pixels.

  12. Fibre Optic Notch Filter For The Antiproton Decelerator Stochastic Cooling System

    CERN Document Server

    Simmonds, Max Vincent John

    2016-01-01

    The project scope included reverse engineering, upgrading, and recovering the operational conditions of an existing fibre optic notch filter. Once operational, tests were to be preformed to confirm the performance of the temperature stabilisation. The end goal is to use said notch filter in the Antiproton Decelerator (AD) facility at CERN to help aid antimatter research. The notch filter was successfully reverse engineered and then documented. Changes were made in order to increase performance and reliability, and also allow easy integration into the AD. An additional phase was added whereby the notch filter was to be controller via a touchscreen computer, situated next to the filter, allowing engineers to set-up each of the electronic devices used. While one of the devices (Motorised Delay Line) can be controlled by the touchscreen computer, the other two cannot.Due to time constraints and difficulties with the Beckhoff TwincatII programming language, the USB devices were not able to be controlled via the To...

  13. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

    Science.gov (United States)

    Woodford, Mark R.; Dunn, Diana M.; Blanden, Adam R.; Capriotti, Dante; Loiselle, David; Prodromou, Chrisostomos; Panaretou, Barry; Hughes, Philip F.; Smith, Aaron; Ackerman, Wendi; Haystead, Timothy A.; Loh, Stewart N.; Bourboulia, Dimitra; Schmidt, Laura S.; Marston Linehan, W.; Bratslavsky, Gennady; Mollapour, Mehdi

    2016-01-01

    Heat shock protein-90 (Hsp90) is an essential molecular chaperone in eukaryotes involved in maintaining the stability and activity of numerous signalling proteins, also known as clients. Hsp90 ATPase activity is essential for its chaperone function and it is regulated by co-chaperones. Here we show that the tumour suppressor FLCN is an Hsp90 client protein and its binding partners FNIP1/FNIP2 function as co-chaperones. FNIPs decelerate the chaperone cycle, facilitating FLCN interaction with Hsp90, consequently ensuring FLCN stability. FNIPs compete with the activating co-chaperone Aha1 for binding to Hsp90, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Lastly, downregulation of FNIPs desensitizes cancer cells to Hsp90 inhibitors, whereas FNIPs overexpression in renal tumours compared with adjacent normal tissues correlates with enhanced binding of Hsp90 to its inhibitors. Our findings suggest that FNIPs expression can potentially serve as a predictive indicator of tumour response to Hsp90 inhibitors. PMID:27353360

  14. The series elastic shock absorber: tendon elasticity modulates energy dissipation by muscle during burst deceleration.

    Science.gov (United States)

    Konow, Nicolai; Roberts, Thomas J

    2015-04-07

    During downhill running, manoeuvring, negotiation of obstacles and landings from a jump, mechanical energy is dissipated via active lengthening of limb muscles. Tendon compliance provides a 'shock-absorber' mechanism that rapidly absorbs mechanical energy and releases it more slowly as the recoil of the tendon does work to stretch muscle fascicles. By lowering the rate of muscular energy dissipation, tendon compliance likely reduces the risk of muscle injury that can result from rapid and forceful muscle lengthening. Here, we examine how muscle-tendon mechanics are modulated in response to changes in demand for energy dissipation. We measured lateral gastrocnemius (LG) muscle activity, force and fascicle length, as well as leg joint kinematics and ground-reaction force, as turkeys performed drop-landings from three heights (0.5-1.5 m centre-of-mass elevation). Negative work by the LG muscle-tendon unit during landing increased with drop height, mainly owing to greater muscle recruitment and force as drop height increased. Although muscle strain did not increase with landing height, ankle flexion increased owing to increased tendon strain at higher muscle forces. Measurements of the length-tension relationship of the muscle indicated that the muscle reached peak force at shorter and likely safer operating lengths as drop height increased. Our results indicate that tendon compliance is important to the modulation of energy dissipation by active muscle with changes in demand and may provide a mechanism for rapid adjustment of function during deceleration tasks of unpredictable intensity.

  15. Unsteady pressure measurements of decelerated swirling flow in a discharge cone at lower runner speeds

    Science.gov (United States)

    Bosioc, A. I.; Muntean, S.; Tanasa, C.; Susan-Resiga, R.; Vékás, L.

    2014-03-01

    The decelerated swirling flow in the draft tube cone of hydraulic turbines (especially turbines with fixed blades) is responsible for self-induced instabilities which generates pressure pulsations that hinder the turbine operation. An experimental test rig was developed in order to investigate the flow instabilities. A new method was implemented to slow down the runner using a magneto rheological brake in order to be extended the flow regimes investigated. As a result, the experimental investigations are performed for 7 operating regimes in order to quantify the flow behaviour from part load operation to overload operation. The unsteady pressure measurements are carried out on 4 levels in the cone. The unsteady pressure measurements on the cone wall consist in quantifying of three aspects: i) the pressure recovery coefficient obtained based on mean pressure provides the energetic assessment on the draft tube cone; ii) the unsteady quantities (dominant amplitude and frequency) are determined revealing the dynamic behaviour; iii) the plunging and rotating components of the pressure pulsation. As a result, this new method helps us to investigate in detail the flow instability for different operating regimes and allows investigating various flow control solutions.

  16. Mission and Design Sensitivities for Human Mars Landers Using Hypersonic Inflatable Aerodynamic Decelerators

    Science.gov (United States)

    Polsgrove, Tara P.; Thomas, Herbert D.; Collins, Tim; Dwyer Cianciolo, Alicia; Samareh, Jamshid

    2017-01-01

    Landing humans on Mars is one of NASA's long term goals. The Evolvable Mars Campaign (EMC) is focused on evaluating architectural trade options to define the capabilities and elements needed for a sustainable human presence on the surface of Mars. The EMC study teams have considered a variety of in-space propulsion options and surface mission options. As we seek to better understand how these choices affect the performance of the lander, this work informs and influences requirements for transportation systems to deliver the landers to Mars and enable these missions. This paper presents the effects of mission and vehicle design options on lander mass and performance. Beginning with Earth launch, options include fairing size assumptions, co-manifesting other elements with the lander, and Earth-Moon vicinity operations. Capturing into Mars orbit using either aerocapture or propulsive capture is assessed. For entry, descent, and landing both storable as well as oxygen and methane propellant combinations are considered, engine thrust level is assessed, and sensitivity to landed payload mass is presented. This paper focuses on lander designs using the Hypersonic Inflatable Aerodynamic Decelerators (HIAD), one of several entry system technologies currently considered for human missions.

  17. H0, q0 and the local velocity field. [Hubble and deceleration constants in Big Bang expansion

    Science.gov (United States)

    Sandage, A.; Tammann, G. A.

    1982-01-01

    An attempt is made to find a systematic deviation from linearity for distances that are under the control of the Virgo cluster, and to determine the value of the mean random motion about the systematic flow, in order to improve the measurement of the Hubble and the deceleration constants. The velocity-distance relation for large and intermediate distances is studied, and type I supernovae are calibrated relatively as distance indicators and absolutely to obtain a new value for the Hubble constant. Methods of determining the deceleration constant are assessed, including determination from direct measurement, mean luminosity density, virgocentric motion, and the time scale test. The very local velocity field is investigated, and a solution is preferred with a random peculiar radial velocity of very nearby field galaxies of 90-100 km/s, and a Virgocentric motion of the local group of 220 km/s, leading to an underlying expansion rate of 55, in satisfactory agreement with the global value.

  18. Deceleration, precooling, and multi-pass stopping of highly charged ions in Be⁺ Coulomb crystals.

    Science.gov (United States)

    Schmöger, L; Schwarz, M; Baumann, T M; Versolato, O O; Piest, B; Pfeifer, T; Ullrich, J; Schmidt, P O; López-Urrutia, J R Crespo

    2015-10-01

    Preparing highly charged ions (HCIs) in a cold and strongly localized state is of particular interest for frequency metrology and tests of possible spatial and temporal variations of the fine structure constant. Our versatile preparation technique is based on the generic modular combination of a pulsed ion source with a cryogenic linear Paul trap. Both instruments are connected by a compact beamline with deceleration and precooling properties. We present its design and commissioning experiments regarding these two functionalities. A pulsed buncher tube allows for the deceleration and longitudinal phase-space compression of the ion pulses. External injection of slow HCIs, specifically Ar(13+), into the linear Paul trap and their subsequent retrapping in the absence of sympathetic cooling is demonstrated. The latter proved to be a necessary prerequisite for the multi-pass stopping of HCIs in continuously laser-cooled Be(+) Coulomb crystals.

  19. Deceleration of a continuous-wave(CW)molecular beam with a single quasi-CW semi-Gaussian laser beam

    Institute of Scientific and Technical Information of China (English)

    Yin Ya-Ling; Xia Yong; Yin Jian-Ping

    2008-01-01

    We propose a promising scheme to decelerate a CW molecular beam by using a red-detuned quasi-cw semi-Gaussian laser beam(SGB).We study the dynamical process of the deceleration for a CW deuterated ammonia(ND3)molecular beam by Monte-Carlo simulation method.Our study shows that we can obtain a ND3 molecular beam with a relative average kinetic energy loss of about 10% and a relative output molecular number of more than 90% by using a single quasi-cw SGB with a power of 1.5kW and a maximum optical well depth of 7.33mK.

  20. Deceleration, precooling, and multi-pass stopping of highly charged ions in Be{sup +} Coulomb crystals

    Energy Technology Data Exchange (ETDEWEB)

    Schmöger, L., E-mail: lisa.schmoeger@mpi-hd.mpg.de; Schwarz, M.; Versolato, O. O. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Physikalisch-Technische Bundesanstalt, Bundesallee 100, 38116 Braunschweig (Germany); Baumann, T. M.; Piest, B.; Pfeifer, T.; Crespo López-Urrutia, J. R. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Ullrich, J. [Physikalisch-Technische Bundesanstalt, Bundesallee 100, 38116 Braunschweig (Germany); Schmidt, P. O. [Physikalisch-Technische Bundesanstalt, Bundesallee 100, 38116 Braunschweig (Germany); Institut für Quantenoptik, Leibniz Universität Hannover, Welfengarten 1, 30167 Hannover (Germany)

    2015-10-15

    Preparing highly charged ions (HCIs) in a cold and strongly localized state is of particular interest for frequency metrology and tests of possible spatial and temporal variations of the fine structure constant. Our versatile preparation technique is based on the generic modular combination of a pulsed ion source with a cryogenic linear Paul trap. Both instruments are connected by a compact beamline with deceleration and precooling properties. We present its design and commissioning experiments regarding these two functionalities. A pulsed buncher tube allows for the deceleration and longitudinal phase-space compression of the ion pulses. External injection of slow HCIs, specifically Ar{sup 13+}, into the linear Paul trap and their subsequent retrapping in the absence of sympathetic cooling is demonstrated. The latter proved to be a necessary prerequisite for the multi-pass stopping of HCIs in continuously laser-cooled Be{sup +} Coulomb crystals.

  1. EFECTOS DE LA HEMODILUCIÓN NORMOVOLÉMICA CON AUTODONACIÓN DE BAJO VOLUMEN SOBRE ALGUNOS PARÁMETROS HEMATOLÓGICOS EN LA CIRUGÍA CARDIOVASCULAR CON CIRCULACIÓN EXTRACORPÓREA / Effects of normovolemic hemodilution with low volume autologous donations on various hematological parameters in cardiovascular surgery with cardiopulmonary bypass

    Directory of Open Access Journals (Sweden)

    Shemanet García Cid

    2011-09-01

    Full Text Available Introduction and Objectives: Cardiac surgery with extracorporeal circulation is characterized by large perioperative blood loss and multifactorial disorders of coagulation parameters. For these reasons, there is frequent use of allogeneic transfusions. The purpose of this study was to determine the effects of intentional normovolemic hemodilution, with low volume autologous donation, on some hematological parameters in patients undergoing cardiopulmonary bypass. Method: A longitudinal, comparative, prospective study was performed in 27 patients who underwent cardiovascular surgery with cardiopulmonary bypass, subjected to intentional low volume normovolemic hemodilution. The following parameters were studied: the patient's blood volume, bleeding count, hematocrit figures, platelet count, thromboplastin time and INR before and after hemodilution and autotransfusion. Results: A blood volume average extraction of 10.5% for men and 13,12 % for women was found, with a highly significant reduction in hematocrit, and a significant reduction in platelet, although both variables were within normal values, without involvement of the coagulation parameters with hemodilution. After autotransfusion, a highly significant increase in hematocrit and platelet count was found, with significant reduction of thromboplastin time and INR. Conclusions: The low volume normovolemic hemodilution does not produce clinically important changes in the studied hematological parameters, and autotransfusion after cardiopulmonary bypass improves these parameters.

  2. The Relationship Between Decelerations with Late Components in the Second Stage of Labor and Umbilical Cord Artery PH

    Science.gov (United States)

    1993-01-01

    Infant Apgar Score at Five Minutes ... ....... 19 5 Summary of Decelerations with Late Components for pH ɟ.2 ............ ................... 20 6 Summary... Apgar score , presence of nuchal cords, and pregnancy complications. These data were compiled to describe the characteristics of the population...2) 10% (3) The one minute Apgar scores ranged from five to nine. The two infants with a one minute score of five were divided between the groups

  3. Decelerating chirped soliton formation at femtosecond laser pulse propagation in a medium with one-photon absorption and gold nanorods

    Science.gov (United States)

    Trofimov, V. A.; Lysak, T. M.

    2017-01-01

    We demonstrate the possibility of decelerating chirped soliton formation at femtosecond pulse propagation in a medium with gold nanoparticles. We take into account the dependence of one-photon absorption on the nanorod aspect ratio and time-dependent nanorod aspect ratio changing due to nanorod reshaping because of laser energy absorption. The soliton formation occurs due to laser radiation trapping by the nanorod reshaping front. We show analytically that a chirp induced by the negative phase grating is crucial for this trapping.

  4. Inertia Identification and PI Parameter Tuning of PMSM Servo Drives

    Science.gov (United States)

    Lei, Huang

    2017-05-01

    The goal of this paper is to improve the performance of permanent magnet synchronous motor(PMSM) servo system by identification of the inertia parameter and auto-tuning of PI parameters. The method relies on the speed acceleration and deceleration response produced by speed ramp signals applied to a speed-controlled servo. The proposed method relies on simple numerical calculations, thus make the proposed scheme more practical. After the knowledge of the inertia parameter, the tuning of the speed control loop can be performed. The experimental results verified that the proposed identification scheme can estimate inertia parameters accurately and effectively and the control system tuned can achieve good dynamic performance.

  5. Faranoff-Riley type I jet deceleration at density discontinuities "Relativistic hydrodynamics with realistic equation of state"

    CERN Document Server

    Meliani, Z; Giacomazzo, B

    2008-01-01

    The deceleration mechanisms for relativistic jets in active galactic nuclei remain an open question, and in this paper we propose a model which could explain sudden jet deceleration, invoking density discontinuities. This is particularly motivated by recent indications from HYMORS. Exploiting high resolution, numerical simulations, we demonstrate that for both high and low energy jets, always at high Lorentz factor, a transition to a higher density environment can cause a significant fraction of the directed jet energy to be lost on reflection. This can explain how one-sided jet deceleration and a transition to FR I type can occur in HYMORS, which start as FR II (and remain so on the other side). For that purpose, we implemented in the relativistic hydrodynamic grid-adaptive AMRVAC code, the Synge-type equation of state introduced in the general polytropic case by Meliani et al. (2004). We present results for 10 model computations, varying the inlet Lorentz factor from 10 to 20, including uniform or decreasin...

  6. Deceleration of High-velocity Interstellar Photon Sails into Bound Orbits at α Centauri

    Science.gov (United States)

    Heller, René; Hippke, Michael

    2017-02-01

    At a distance of about 4.22 ly, it would take about 100,000 years for humans to visit our closest stellar neighbor Proxima Centauri using modern chemical thrusters. New technologies are now being developed that involve high-power lasers firing at 1 gram solar sails in near-Earth orbits, accelerating them to 20% the speed of light (c) within minutes. Although such an interstellar probe could reach Proxima 20 years after launch, without propellant to slow it down it would traverse the system within hours. Here we demonstrate how the stellar photon pressures of the stellar triple α Cen A, B, and C (Proxima) can be used together with gravity assists to decelerate incoming solar sails from Earth. The maximum injection speed at α Cen A to park a sail with a mass-to-surface ratio (σ) similar to graphene (7.6 × 10-4 gram m-2) in orbit around Proxima is about 13,800 km s-1 (4.6% c), implying travel times from Earth to α Cen A and B of about 95 years and another 46 years (with a residual velocity of 1280 km s-1) to Proxima. The size of such a low-σ sail required to carry a payload of 10 grams is about 105 m2 = (316 m)2. Such a sail could use solar photons instead of an expensive laser system to gain interstellar velocities at departure. Photogravitational assists allow visits of three stellar systems and an Earth-sized potentially habitable planet in one shot, promising extremely high scientific yields.

  7. Biochar Decelerates Soil Organic Nitrogen Cycling but Stimulates Soil Nitrification in a Temperate Arable Field Trial

    Science.gov (United States)

    Prommer, Judith; Wanek, Wolfgang; Hofhansl, Florian; Trojan, Daniela; Offre, Pierre; Urich, Tim; Schleper, Christa; Sassmann, Stefan; Kitzler, Barbara; Soja, Gerhard; Hood-Nowotny, Rebecca Clare

    2014-01-01

    Biochar production and subsequent soil incorporation could provide carbon farming solutions to global climate change and escalating food demand. There is evidence that biochar amendment causes fundamental changes in soil nutrient cycles, often resulting in marked increases in crop production, particularly in acidic and in infertile soils with low soil organic matter contents, although comparable outcomes in temperate soils are variable. We offer insight into the mechanisms underlying these findings by focusing attention on the soil nitrogen (N) cycle, specifically on hitherto unmeasured processes of organic N cycling in arable soils. We here investigated the impacts of biochar addition on soil organic and inorganic N pools and on gross transformation rates of both pools in a biochar field trial on arable land (Chernozem) in Traismauer, Lower Austria. We found that biochar increased total soil organic carbon but decreased the extractable organic C pool and soil nitrate. While gross rates of organic N transformation processes were reduced by 50–80%, gross N mineralization of organic N was not affected. In contrast, biochar promoted soil ammonia-oxidizer populations (bacterial and archaeal nitrifiers) and accelerated gross nitrification rates more than two-fold. Our findings indicate a de-coupling of the soil organic and inorganic N cycles, with a build-up of organic N, and deceleration of inorganic N release from this pool. The results therefore suggest that addition of inorganic fertilizer-N in combination with biochar could compensate for the reduction in organic N mineralization, with plants and microbes drawing on fertilizer-N for growth, in turn fuelling the belowground build-up of organic N. We conclude that combined addition of biochar with fertilizer-N may increase soil organic N in turn enhancing soil carbon sequestration and thereby could play a fundamental role in future soil management strategies. PMID:24497947

  8. Experimental Study of Hypersonic Inflatable Aerodynamic Decelerator (HIAD) Aeroshell with Axisymmetric Surface Deflection Patterns

    Science.gov (United States)

    Hollis, Brian R.; Hollingsworth, Kevin E.

    2017-01-01

    A wind tunnel test program was conducted to obtain aeroheating environment data on Hypersonic Inflatable Aerodynamic Decelerator aeroshells with flexible thermal protection systems. Data were obtained on a set of rigid wind tunnel models with surface deflection patterns of various heights that simulated a range of potential in-flight aeroshell deformations. Wind tunnel testing was conducted at Mach 6 at unit Reynolds numbers from 2.1 × 10(exp 6)/ft to 8.3 × 10(exp 6)/ft and angles of attack from 0 deg to 18 deg. Boundary-layer transition onset and global surface heating distribution measurements were performed using phosphor thermography and flow field images were obtained through schlieren photography. Surface deflections were found to both promote early transition of the boundary layer and to augment heating levels for both laminar and turbulent flows. A complimentary computational flow field study was also performed to provide heating predictions for comparison with the measurements as well as boundary layer flow field properties for use in correlating the data. Correlations of the wind tunnel data were developed to predict deflection effects on boundary layer transition and surface heating and were applied to both the wind tunnel test conditions and to the trajectory of NASA's successful IRVE-3 flight test. In general, the correlations produced at least qualitative agreement with the wind tunnel data, although the heating levels were underpredicted for some of the larger surface deflections. For the flight conditions, the correlations suggested that peak heating levels on the leeward side conical flank of the IRVE-3 vehicle may have exceeded those at nose for times late in the trajectory after the peak heating time point. However, the flight estimates were based on a conservative assumption of surface deflection magnitude (i.e., larger) than likely was produced in flight.

  9. Biochar decelerates soil organic nitrogen cycling but stimulates soil nitrification in a temperate arable field trial.

    Directory of Open Access Journals (Sweden)

    Judith Prommer

    Full Text Available Biochar production and subsequent soil incorporation could provide carbon farming solutions to global climate change and escalating food demand. There is evidence that biochar amendment causes fundamental changes in soil nutrient cycles, often resulting in marked increases in crop production, particularly in acidic and in infertile soils with low soil organic matter contents, although comparable outcomes in temperate soils are variable. We offer insight into the mechanisms underlying these findings by focusing attention on the soil nitrogen (N cycle, specifically on hitherto unmeasured processes of organic N cycling in arable soils. We here investigated the impacts of biochar addition on soil organic and inorganic N pools and on gross transformation rates of both pools in a biochar field trial on arable land (Chernozem in Traismauer, Lower Austria. We found that biochar increased total soil organic carbon but decreased the extractable organic C pool and soil nitrate. While gross rates of organic N transformation processes were reduced by 50-80%, gross N mineralization of organic N was not affected. In contrast, biochar promoted soil ammonia-oxidizer populations (bacterial and archaeal nitrifiers and accelerated gross nitrification rates more than two-fold. Our findings indicate a de-coupling of the soil organic and inorganic N cycles, with a build-up of organic N, and deceleration of inorganic N release from this pool. The results therefore suggest that addition of inorganic fertilizer-N in combination with biochar could compensate for the reduction in organic N mineralization, with plants and microbes drawing on fertilizer-N for growth, in turn fuelling the belowground build-up of organic N. We conclude that combined addition of biochar with fertilizer-N may increase soil organic N in turn enhancing soil carbon sequestration and thereby could play a fundamental role in future soil management strategies.

  10. Quantitative MRI reveals decelerated fatty infiltration in muscles of active FSHD patients.

    Science.gov (United States)

    Janssen, Barbara; Voet, Nicoline; Geurts, Alexander; van Engelen, Baziel; Heerschap, Arend

    2016-05-03

    To investigate the effects of aerobic exercise training (AET) and cognitive-behavioral therapy (CBT), directed towards an increase in daily physical activity, on the progression of fatty infiltration and edema in skeletal muscles of patients with facioscapulohumeral muscular dystrophy (FSHD) type 1 by T2 MRI. Quantitative T2 MRI (qT2 MRI) and fat-suppressed T2 MRI of the thigh were performed at 3T on 31 patients, 13 of whom received usual care (UC), 9 AET, and 9 CBT. Muscle-specific fat fractions (%), derived from qT2 MRI, were recorded pretreatment and posttreatment. Intervention effects were analyzed by comparing fat fraction progression rates of the UC with the treated groups using Mann-Whitney tests, and intermuscle differences by a linear mixed model. Edematous hyperintense lesions were identified on the fat-suppressed T2 MRI. The intraclass correlation coefficient for reproducibility of qT2 MRI fat assessment was 0.99. In the UC group, the fat fraction increased by 6.7/year (95% confidence interval [CI] 4.3 to 9.1). This rate decreased to 2.9/year (95% CI 0.7 to 5.2) in the AET (p = 0.03) and 1.7/year (95% CI -0.2 to 3.6) in the CBT group (p = 0.00015). The treatment effect differed among individual muscles. Fewer new edematous lesions occurred after therapy. Fat fraction derived from qT2 MRI is a reproducible and sensitive biomarker to monitor the effects of increased physical activity in individual muscles. This biomarker reports a favorable effect of AET and CBT on the rate of muscular deterioration in FSHD as reflected in decelerated fat replacement. This study provides Class II evidence that for patients with FSHD type 1, both AET and CBT decrease the rate of fatty infiltration in muscles. © 2016 American Academy of Neurology.

  11. Cortical bone tissue resists fatigue fracture by deceleration and arrest of microcrack growth.

    Science.gov (United States)

    Akkus, O; Rimnac, C M

    2001-06-01

    Knowledge of kinetics of fatigue crack growth of microcracks is important so as to understand the dynamics of bone adaptation, remodeling, and the etiology of fatigue-based failures of cortical bone tissue. In this respect, theoretical models (Taylor, J. Biomech., 31 (1998) 587-592; Taylor and Prendergast, Proc. Instn. Mech. Engrs. Part H 211 (1997) 369-375) of microcrack growth in cortical bone have predicted a decreasing microcrack growth rate with increasing microcrack length. However, these predictions have not been observed directly. This study investigated microcrack growth and arrest through observations of surface microcracks during cyclic loading (R=0.1, 50-80MPa) of human femoral cortical bone (male, n=4, age range: 37-40yr) utilizing a video microscopy system. The change in crack length and orientation of eight surface microcracks were measured with the number of fatigue cycles from four specimens. At the applied cyclic stresses, the microcracks propagated and arrested in generally less than 10,000 cycles. The fatigue crack growth rate of all microcracks decreased with increasing crack length following initial identification, consistent with theoretical predictions. The growth rate of the microcracks was observed to be in the range of 5x10(-5) to 5x10(-7)mmcycle(-1). In addition, many of the microcracks were observed not to grow beyond 150 microm and a cyclic stress intensity factor of 0.5MNm(-3/2). The results of this study suggest that cortical bone tissue may resist fracture at the microscale by deceleration of fatigue crack growth and arrest of microcracks.

  12. Parameters, Volume 18, Number 1, March 1988.

    Science.gov (United States)

    1988-03-01

    frontation, with two barrels of machismo out in the middle of the street on the edge of the void about to blow each other to smithereens. He was not...Canada and Mexico , the wresting of Cuba and the Philippines from Spain, and even the Civil War. American soldiers fought not to conquer but to achieve the...Assistant Army Attache in Mexico . March 1988 61 0 25 50) Kilometers o 2 50 miles HONDURAS0 Tegucigalpa* MR V1I P 3 Estel MRRV MR 1 ft"* Mia us

  13. Aerodynamic Heating of Terminal-sensitive Submunition on Deceleration and Despinning Trajectory%末敏子弹减速减旋弹道的气动加热

    Institute of Scientific and Technical Information of China (English)

    张俊; 刘荣忠; 郭锐; 高天宇; 吴国夫

    2015-01-01

    The surface infrared radiation(IR)of terminal-sensitive submunition(TSS)mainly comes from the aerodynamic heating after it is projected out of the carrier capsule under the gas thrust generated by gunpowder.Aiming at this problem,SIMULINK was used to build the trajectory simulation-model of TSS at deceleration and despinning stage,and the change laws of the ballistic data were solved and analyzed.Taking some specific ballistic data and airflow parameters as the inlet flow condition,FLUENT was used to simulate the aerodynamic heating and analyze the dis-tribution of the surface transient temperature and pressure.The results show that at the deceleration and despinning stage,the velocity of TSS is relatively lower,and the surface temperature gradient and IR characteristics are not obvious.The high temperature area is concentrated on the warhead,the umbrella plate and the connecting rod.The stagnation temperature obtained by numerical simulation reasonably agrees with the engineering calculation result.The results are useful to the infrared warning reconnaissance technology of terminal-sensitive projectile.%末敏子弹在火药燃气推力作用下从母弹舱内抛出后,其表面红外辐射主要源于减速减旋运动产生的气动加热。针对此问题,应用 SIMULINK 建立了末敏子弹减速减旋弹道的仿真模型,求解并分析了弹道诸元的变化规律。以部分弹道数据和气流参数为来流条件,利用 FLUENT 对其气动热进行了数值模拟,分析了不同飞行条件下的表面瞬态温度、压力分布规律。结果表明:末敏子弹在减速减旋段的速度较低,表面温度梯度较小,红外辐射特征较弱;高温区集中在弹头附近、伞盘以及连接杆部位;驻点温度的仿真结果与工程计算结果吻合较好。研究结论可为末敏弹的红外侦察预警仿真技术提供帮助。

  14. Volume Entropy

    CERN Document Server

    Astuti, Valerio; Rovelli, Carlo

    2016-01-01

    Building on a technical result by Brunnemann and Rideout on the spectrum of the Volume operator in Loop Quantum Gravity, we show that the dimension of the space of the quadrivalent states --with finite-volume individual nodes-- describing a region with total volume smaller than $V$, has \\emph{finite} dimension, bounded by $V \\log V$. This allows us to introduce the notion of "volume entropy": the von Neumann entropy associated to the measurement of volume.

  15. Structural Testing of a 6m Hypersonic Inflatable Aerodynamic Decelerator System

    Science.gov (United States)

    Swanson, G. T.; Kazemba, C. D.; Johnson, R. K.; Hughes, S. J.; Calomino, A. M.

    2015-01-01

    NASA is developing low ballistic coefficient technologies to support the Nations long-term goal of landing humans on Mars. Current entry, decent, and landing technologies are not practical for this class of payloads due to geometric constraints dictated by current and future launch vehicle fairing limitations. Hypersonic Inflatable Aerodynamic Decelerators (HIADs) are being developed to circumvent this limitation and are now considered a leading technology to enable landing of heavy payloads on Mars. At the beginning of 2014, a 6m diameter HIAD inflatable structure with an integrated flexible thermal protection system (TPS) was subjected to a static load test series to verify its structural performance under flight-relevant loads. The inflatable structure was constructed into a 60 degree sphere-cone configuration using nine inflatable torus segments composed of fiber-reinforced thin films. The inflatable tori were joined together using adhesives and high-strength textile woven structural straps. These straps help distribute the load throughout the inflatable structure. The 6m flexible TPS was constructed using multiple layers of high performance materials that are designed to protect the inflatable structure from heat loads that would be seen in flight during atmospheric entry. A custom test fixture was constructed to perform the static load test series. The fixture consisted of a round structural tub with enough height and width to allow for displacement of the HIAD test article as loads were applied. The bottom of the tub rim had an airtight seal with the floor. The rigid centerbody of the HIAD was mounted to a pedestal in the center of the structural tub. Using an impermeable membrane draped over the HIAD test article, an airtight seal was created with the top rim of the static load tub. This seal allowed partial vacuum to be pulled beneath the HIAD resulting in a uniform static pressure load applied to the outer surface. Using this technique, the test article

  16. Quota Restrictions on Land Use for Decelerating Urban Sprawl of Mega City: A Case Study of Shanghai, China

    Directory of Open Access Journals (Sweden)

    Yunqian Zhang

    2016-09-01

    Full Text Available The mega cities of China are faced with great pressure from conflict between huge land demand for construction use and limited resources. To improve this situation, it is necessary to slow the increasing rate of built-up land and even reduce the existing built-up land by improving land use efficiency. Herein, land use planning with urban sprawl deceleration is proposed. Land quotas are important tools for the control of land use planning in China, but the current quotas are mainly in the form of increment, thus cannot support land use planning with urban sprawl deceleration. To address these issues, we developed a model named “current-plan-requirement response (CPRR”, to optimize the land quotas. With this model, we investigated the current status of land use, the process of land use planning, and the requirements of land use planning with urban sprawl deceleration in Shanghai. It was found that the current land quotas have provided somewhat inhabited conversion of arable land to built-up land, but scarcely any regulation of land use efficiency or protection of natural environment. Then, the land quotas were optimized and quota management recommendations were made. The optimized land quotas included four aspects of quotas: arable land protection, ecological conservation, scale constraint on built-up land and economical and intensive land use. These new land quotas could be used to guide reduction of built-up land and increase ecological land in China’s mega cities. It might also be beneficial for easing conflict between supply and demand of built-up land, for building an eco-friendly city land-use structure.

  17. The cost of transport of human running is not affected, as in walking, by wide acceleration/deceleration cycles.

    Science.gov (United States)

    Minetti, Alberto E; Gaudino, Paolo; Seminati, Elena; Cazzola, Dario

    2013-02-15

    Although most of the literature on locomotion energetics and biomechanics is about constant-speed experiments, humans and animals tend to move at variable speeds in their daily life. This study addresses the following questions: 1) how much extra metabolic energy is associated with traveling a unit distance by adopting acceleration/deceleration cycles in walking and running, with respect to constant speed, and 2) how can biomechanics explain those metabolic findings. Ten males and ten females walked and ran at fluctuating speeds (5 ± 0, ± 1, ± 1.5, ± 2, ± 2.5 km/h for treadmill walking, 11 ± 0, ± 1, ± 2, ± 3, ± 4 km/h for treadmill and field running) in cycles lasting 6 s. Field experiments, consisting of subjects following a laser spot projected from a computer-controlled astronomic telescope, were necessary to check the noninertial bias of the oscillating-speed treadmill. Metabolic cost of transport was found to be almost constant at all speed oscillations for running and up to ±2 km/h for walking, with no remarkable differences between laboratory and field results. The substantial constancy of the metabolic cost is not explained by the predicted cost of pure acceleration/deceleration. As for walking, results from speed-oscillation running suggest that the inherent within-stride, elastic energy-free accelerations/decelerations when moving at constant speed work as a mechanical buffer for among-stride speed fluctuations, with no extra metabolic cost. Also, a recent theory about the analogy between sprint (level) running and constant-speed running on gradients, together with the mechanical determinants of gradient locomotion, helps to interpret the present findings.

  18. The Q Values of the Galilean Satellites and their Tidal Contributions to the Deceleration of Jupiter's Rotation

    Institute of Scientific and Technical Information of China (English)

    Hong Zhang; Cheng-Zhi Zhang

    2004-01-01

    The relationship between the k2/Q of the Galilean satellites and the k2J/QJ of Jupiter is derived from energy and momentum considerations. Calculations suggest that the Galilean satellites can be divided into two classes according to their Q values: Io and Ganymede have values between 10 and 50, while Europa and Callisto have values ranging from 200 to 700. The tidal contributions of the Galilean satellites to Jupiter's rotation are estimated. The main deceleration of Jupiter, which is about 99.04% of the total, comes from Io.

  19. Temperature induced transition from acceleration to deceleration of the diffusion of polymers by soft nanoparticles in their composite

    Science.gov (United States)

    Jiao, Gui-Sheng; Qian, Hu-Jun; Lu, Zhong-Yuan

    2017-06-01

    It is well known that the presence of nanoparticles in polymer melt can dramatically influence the dynamics of the polymers. Here from a molecular dynamics simulation study, we find that such influences can be largely temperature dependent in a polymer/single chain nanoparticle composite. At high temperature, the translational diffusion of polymers can be accelerated due to large deformability of nanoparticle surface. While when temperature decreases, nanoparticle surface deformability decreases dramatically and therefore nanoparticles can impose large excess free energy barrier on polymer diffusion. As a consequence, the diffusion of polymers at low temperature can be largely decelerated.

  20. Three Dimensional Separation with Spiral-Focus in a Decelerating Duct Flow (Effect of Asymmetric Inlet Boundary Layer Thickness)

    Institute of Scientific and Technical Information of China (English)

    Yoichi Kinoue; Toshiaki Setoguchi; Kenji Kaneko; Mamun Mohammad; Masahiro Inoue

    2003-01-01

    An experimental apparatus was developed to study the three dimensional separated flow with spiral-foci. The internal decelerating flow was generated by the air suction from a side wall to produce the separation on an opposite-side wall. The relation between the upstream boundary layer and the generation of spiral-foci in the separation region was observed by a tuft method. As a result, it was clarified that the spiral-focus type separation could be produced on the side wall and its behavior was closely related to the vortices supplied into the separation region from the boundary layer developing along top wall or bottom one.

  1. Anthropometric parameters: weight height, body mass index and mammary volume in relationship with the mammographic pattern; Parametros antropmetricos: peso, talla, indice de masa corporal y volumen mamario, en relacion con el patron mamografico

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Candela, V.; Busto, C.; Avila, R.; Marrero, M. G.; Liminana, J. M.; Orengo, J. C. [Hospital Universitario Maternoinfantil de Canarias. Las Palmas de Gran Canaria (Spain)

    2001-07-01

    A prospective study to attempt to relate the anthropometric parameters of height, weight, body mass index as well as age with the mammographic patterns obtained for the patients and obtain an anthropometric profile was carried out. The study was performed in 1.000 women who underwent a mammography in cranial-caudal and medial lateral oblique projection of both breasts, independently of whether they were screened or diagnosed. Prior to the performance of the mammography, weight and height were obtained, and this was also performed by the same technicians, and the patient were asked their bra size to deduce breast volume. With the weight, the body mass index of Quetelet was calculated (weight [kg]/height''2 (ml)). After reading the mammography, the patient was assigned to one of the four mammographic patterns considered in the BIRADS (Breast Imaging Reporting and Data System) established by the ACR (American College of Radiology): type I (fat). type II (disperse fibroglandular densities), type III (fibroglandular densities distributed heterogeneously), type 4 (dense). The results were introduced into a computer database and the SPSS 8.0 statistical program was applied, using the statistical model of multivariant logistic regression. In women under 40 years, with normal weight, the dense breast pattern accounted for 67.8% and as the body mass index (BMI) increased, this pattern decreased to 25.1%. The fat pattern is 20% and as the BMI increases, this increased to 80%. In 40-60 year old women with normal weight, the dense pattern accounts for 44% and decreases to 20.9% in the grades II, III and IV obese. The fat pattern is 11.1% and increases to 53.7% in the grade II, III and IV obese. In women over 60 with normal, the dense pattern accounts for 19.3% and and decreases to 13% in the grade III obese. The fat pattern is 5.3% and increases to 20.2% in the grade iii of obesity. As age increases, the probability of presenting a mammographic pattern with a fat

  2. The deceleration of aircraft in overrun accidents from the point of first impact to the end of the wreckage path

    Directory of Open Access Journals (Sweden)

    David Pitfield

    2015-02-01

    Full Text Available Purpose: This paper outlines previous attempts to model aircraft deceleration and using a newer database containing a greater number of observations tries to refine the model.Design/Methodology: It is noted that data inadequacies still necessitate the estimation of a given acceleration for the aircraft wreckage path, but that there are more opportunities to change the intercept in a regression model to reflect categorical and dummy variables that proxy factors such as runway condition, the degree of control exercised by the pilot during the crash, the speed at the point of first impact (hereafter POFI, headwind, rain, characteristics of the terrain on the wreckage path  and aborted take-offs. Findings: The contribution of some of the explanatory variables can be seen. It is a shame other potential influences are not found to be significant. It is important to understand deceleration so that the wreckage location of aircraft accidents can be understood. This then gives guidance of appropriate runway safety areas. Originality/ value: This is the first time this has been attempted on the expanded accident database.

  3. Acromioclavicular joint acceleration-deceleration injury as a cause of persistent shoulder pain: Outcome after arthroscopic resection

    Directory of Open Access Journals (Sweden)

    Ehud Atoun

    2014-01-01

    Full Text Available Background: Shoulder pain in general and acromioclavicular joint (ACJ pain specifically is common after acceleration-deceleration injury following road traffic accident (RTA. The outcome of surgical treatment in this condition is not described in the literature. The aim of the present study was to report the outcome of arthroscopic resection of the ACJ in these cases. Materials and Methods: Nine patients with localized ACJ pain, resistant to nonoperative treatment were referred on an average 18 months after the injury. There were 3 male and 6 females. The right shoulder was involved in seven patients and the left in two. The average age was 38.9 years (range 29-46 years. All presented with normal X-rays but with torn acromioclavicular joint disc and effusion on magnetic resonance imaging (MRI. Arthroscopic ACJ excision arthroplasty was performed in all patients. Results: At a mean followup of 18 month, all patients had marked improvement. The Constant score improved from 36 to 81, the pain score from 3/15 to 10/15 and the patient satisfaction improved from 3.5/10 to 9.3/10. Conclusion: Arthroscopic ACJ excision arthroplasty, gives good outcomes in patients not responding to conservative management in ACJ acceleration-deceleration injury.

  4. Theses. Beam studies for the CERN antiproton decelerator and a new interpretation of the resonance theory for betatron motion

    Energy Technology Data Exchange (ETDEWEB)

    De Ninno, G

    1999-07-01

    The two parts of the thesis are a mission-oriented task devoted to solve some practical problems of the Antiproton Decelerator (AD) project at CERN, and a theoretical study leading to a new method for representing and compensating betatron resonances. The AD is a new machine (at the moment under commissioning at CERN) that will allow the collection and the deceleration of an antiproton beam from 3.5 GeV/c down to 100 MeV/c (the momentum favoured for the foreseen physics experiments). The need to employ the AD magnets over a wide range required a careful study of their characteristics. The presence of a solenoid inside the AD electron cooling device generates linear coupling between the transverse degrees of freedom of the single-particle motion. Coupling can lead to operational problems and therefore a compensation scheme had tobe designed. The long-standing problem has been solved of how to establish a relationship between the two standard methods for dealing with linear coupling: the matrix approach and the Hamiltonian approach. The bridge was built by including in the Hamiltonian approach in the high frequency part of the perturbative Hamiltonian due to coupling. The procedure was generalised to the nonlinear case and, a new method was proposed for dealing both with linear and nonlinear resonances. (author)

  5. Deceleration of the solar wind upstream from the earth's bow shock and the origin of diffuse upstream ions

    Science.gov (United States)

    Bame, S. J.; Asbridge, J. R.; Feldman, W. C.; Gosling, J. T.; Paschmann, G.; Skopke, N.

    1980-01-01

    Observations with the Los Alamos Scientific Laboratory/Max-Planck-Institut crossed-fan solar wind ion experiment on ISEE I reveal that the solar wind is decelerated and deflected away from the direction of the earth's bow shock as it enters that portion of the upstream region populated by diffuse bow shock ions and long-period (10-60 s) waves. Typically, the average directed velocity vector changes by 7-10 km/s as it enters the wave region. At times, average speed changes as large as 25-40 km/s are observed. Superposed upon these changes in average flow speed are large amplitude (+ or - 15) fluctuations in flow speed associated with the waves themselves. The observations suggest that the solar wind deceleration is the result of momentum transfer from reflected bow shock ions to the wind via the long-period waves as the reflected ion beams go unstable. The broad angular distributions of the diffuse ions thus appear to be produced as a consequence of the disruption of reflected ion beams.

  6. Influence of the choice of parameters of the TAC in the calculation of volumes for different planners; Influencia de la eleccion de los parametros del TAC en el calculo de volumenes para distintos planificadores

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Mazon, J.; Raba Diez, J. L.; Vazquez Rodriguez, J. A.; Pacheco Baldor, M. T.; Mendiguren Santiago, M. A.

    2011-07-01

    In the Protocol for the control treatment planning systems with ionizing radiation of the proposed SEFM tests to verify proper operation of the calculation in the evaluation of DVH (Dose Volume Histogram). The calculation of the volume that makes a planner may have important implications because it can trigger an overestimation of the dose or otherwise. We present a comparison of the calculation of volumes estimated with 4 different planners.

  7. Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology.

    Science.gov (United States)

    Pötter, Richard; Haie-Meder, Christine; Van Limbergen, Erik; Barillot, Isabelle; De Brabandere, Marisol; Dimopoulos, Johannes; Dumas, Isabelle; Erickson, Beth; Lang, Stefan; Nulens, An; Petrow, Peter; Rownd, Jason; Kirisits, Christian

    2006-01-01

    The second part of the GYN GEC ESTRO working group recommendations is focused on 3D dose-volume parameters for brachytherapy of cervical carcinoma. Methods and parameters have been developed and validated from dosimetric, imaging and clinical experience from different institutions (University of Vienna, IGR Paris, University of Leuven). Cumulative dose volume histograms (DVH) are recommended for evaluation of the complex dose heterogeneity. DVH parameters for GTV, HR CTV and IR CTV are the minimum dose delivered to 90 and 100% of the respective volume: D90, D100. The volume, which is enclosed by 150 or 200% of the prescribed dose (V150, V200), is recommended for overall assessment of high dose volumes. V100 is recommended for quality assessment only within a given treatment schedule. For Organs at Risk (OAR) the minimum dose in the most irradiated tissue volume is recommended for reporting: 0.1, 1, and 2 cm3; optional 5 and 10 cm3. Underlying assumptions are: full dose of external beam therapy in the volume of interest, identical location during fractionated brachytherapy, contiguous volumes and contouring of organ walls for >2 cm3. Dose values are reported as absorbed dose and also taking into account different dose rates. The linear-quadratic radiobiological model-equivalent dose (EQD2)-is applied for brachytherapy and is also used for calculating dose from external beam therapy. This formalism allows systematic assessment within one patient, one centre and comparison between different centres with analysis of dose volume relations for GTV, CTV, and OAR. Recommendations for the transition period from traditional to 3D image-based cervix cancer brachytherapy are formulated. Supplementary data (available in the electronic version of this paper) deals with aspects of 3D imaging, radiation physics, radiation biology, dose at reference points and dimensions and volumes for the GTV and CTV (adding to [Haie-Meder C, Pötter R, Van Limbergen E et al. Recommendations from

  8. The clot burden score, the Boston Acute Stroke Imaging Scale, the cerebral blood volume ASPECTS, and two novel imaging parameters in the prediction of clinical outcome of ischemic stroke patients receiving intravenous thrombolytic therapy

    Energy Technology Data Exchange (ETDEWEB)

    Sillanpaa, Niko; Hakomaki, Jari; Lahteela, Arto; Dastidar, Prasun; Soimakallio, Seppo [Tampere University Hospital, Medical Imaging Center, Tampere (Finland); Saarinen, Jukka T.; Numminen, Heikki; Elovaara, Irina [Tampere University Hospital, Department of Neurology, Tampere (Finland); Rusanen, Harri [Oulu University Hospital, Department of Neurology, Oulu (Finland)

    2012-07-15

    Recently two classification methods based on the location and the extent of thrombosis detected with CT angiography have been introduced: the Boston Acute Stroke Imaging Scale (BASIS) and the clot burden score (CBS). We studied the performance of BASIS and CBS in predicting good clinical outcome (mRS {<=}2 at 90 days) in an acute (<3 h) stroke cohort treated with intravenous thrombolytic therapy. Eighty-three consecutive patients who underwent multimodal CT were analyzed. Binary logistic regression model was used to assess how BASIS, CBS, and cerebral blood volume (CBV) ASPECTS predict favorable clinical outcome. Diagnostic sensitivities and specificities were calculated and compared. Patients with low CBS and CBV ASPECTS scores and major strokes according to BASIS had significantly higher admission NIHSS scores, larger perfusion defects, and more often poor clinical outcome. In logistic regression analysis, CBV ASPECTS, CBS and BASIS were significantly associated with the clinical outcome. The performance of BASIS improved when patients with thrombosis of the M2 segment of the middle cerebral artery were classified as having minor stroke (M1-BASIS). In the anterior circulation, the sum of CBS and CBV ASPECTS (CBSV) proved to be the most robust predictor of favorable outcome. CBV ASPECTS and CBS had high sensitivity but moderate to poor specificity while BASIS was only moderately sensitive and specific. CBS, BASIS, and CBV ASPECTS are statistically robust and sensitive but unspecific predictors of good clinical outcome. Two new derived imaging parameters, CBSV and M1-BASIS, share these properties and may have increased prognostic value. (orig.)

  9. Ventilação mecânica volume-controlada versus pressão controlada em modelo canino de lesão pulmonar aguda: efeitos cardiorrespiratórios e sobre o custo de oxigênio da respiração Volume controlled ventilation versus pressure controlled ventilation in a canine acute lung injury model: effects on cardiorespiratory parameters and oxygen cost of breathing

    Directory of Open Access Journals (Sweden)

    BRUNO DO VALLE PINHEIRO

    2002-01-01

    Full Text Available Introdução: Persiste a questão sobre se há vantagens mecânicas ou de trocas gasosas no uso da ventilação pressão-controlada (VPC sobre a ciclada a volume (VCV. Objetivos: Comparar, de forma randômica, a VPC com a VCV com fluxo desacelerado nos modos assistido e controlado em modelo experimental de lesão pulmonar aguda. Métodos: Sete cães com lesão pulmonar aguda grave (PaO2/FIO2 Background: It is questionable whether pressure-controlled ventilation (PCV has advantages over volume-cycled ventilation (VCV. Objectives: To compare PCV to VCV with decelerating flow profile during assisted and controlled modes in an acute lung injury experimental model. Methods: Severe acute lung injury (PaO2/FIO2 < 100 mmHg was induced by oleic acid IV infusion (0.05 mg/kg in seven dogs. The animals were submitted to PCV and VCV in a randomized sequence. After 40 minutes in the assisted mode, ventilation was changed to the controlled mode after neuromuscular blockade. The tidal volume and the inspiratory time were kept constant throughout the experiment. Results: There were no differences in gas exchange (PaO2 and PaCO2, cardiac output or oxygen delivery (DO2 between VCV and PCV. The same was observed regarding maximum airway and plateau pressures, and also to the static compliance. Oxygen consumption (VO2 after neuromuscular blockade was 124 ± 48 in VCV versus 143 ± 50 ml/min in PCV, p = 0.42. In the assisted mode, there was a statistical trend of a higher VO2 in PCV (219 ± 72 versus 154 ± 67 ml/min in VCV, p = 0.06, that was associated with a statistical trend of a higher oxygen cost of breathing (OCB during assisted PCV, although without statistical significance (31 ± 77 in VCV versus 75 ± 96 ml/min in PCV, p = 0.23, and also in a lower PvO2 (34 ± 7 in PCV versus 42 ± 6 ml/min in VCV, p = 0.02. These occurred despite a higher maximum inspiratory flow in the assisted mode in PCV (58 ± 9 versus 48 ± 4 L/min in VCV, p = 0.01. In both VCV and

  10. Spectroscopy of quasimolecular x rays with H-like decelerated ions

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt-Boecking, H.; Schuch, R.; Tserruya, I.; Hoffmann, R.; Johnson, B.; Jones, K.W.; Justiniano, E.; Meron, M.; Mokler, P.H.; Ingwersen, H.

    1984-11-01

    The quasimolecular 2p..pi..-1s tau transition energy as a function of the internuclear distance is obtained from the interference structure observed in quasimolecular K-x-ray spectra from low energy H-like projectiles measured at certain impact parameters. 15 references, 7 figures.

  11. Parameter Estimation

    DEFF Research Database (Denmark)

    2011-01-01

    of optimisation techniques coupled with dynamic solution of the underlying model. Linear and nonlinear approaches to parameter estimation are investigated. There is also the application of maximum likelihood principles in the estimation of parameters, as well as the use of orthogonal collocation to generate a set......In this chapter the importance of parameter estimation in model development is illustrated through various applications related to reaction systems. In particular, rate constants in a reaction system are obtained through parameter estimation methods. These approaches often require the application...... of algebraic equations as the basis for parameter estimation.These approaches are illustrated using estimations of kinetic constants from reaction system models....

  12. DECELERATION OF ELECTRON VE LOCITY BASED ON THE WAVE- PARTICLE DUALITY LEADS TO RE LATIVE TIME ACCELERATION: HYPOTHESIS OF INCREASED BIOPHYSICAL REACTION VELOCITY

    Directory of Open Access Journals (Sweden)

    Horst Koch

    2013-03-01

    Full Text Available The high speed of biological processes such as photosynthesis, enzymatic reactions or neuronal activity cannot completely be explained on the basis of classic physical approaches. Different quantum biology effects such as tunnelling have been postulated. We hypothetically admit that deceleration of electron velocity based on light-particle duality of electrons leads to time acceleration. Deceleration from the status of light towards a status of a particle may therefore speed up biochemical or biophysical reactions in the atomic or molecular dimension. Electrophysiological and biological phenomena are discussed on the basis of the hypothesis

  13. 基于驾驶员错视觉的振动减速带优化设计%Vibrating Deceleration Strip's Optimization Design Based on Visual Illusion

    Institute of Scientific and Technical Information of China (English)

    杜志刚; 郑展骥; 王自入

    2012-01-01

    Vibrating deceleration strip is a forced deceleration facility, and is the key factor to control vehicle speed and ensure driving safety. In order to strengthen the deceleration effect of the facility, according to the design velocity, the deceleration's figuration was preferred based on the index of vertical vibration acceleration. The size and color of the vibrating deceleration were designed based on the visual illusion principle. The mock video was made by the 3Dmax software, and the SD Method (Semantic Differential Method) was used to evaluate the effect of the design method. The results show that the deceleration strip s parabola-arc figuration has less vertical vibration, and more comfortable than arc figuration. The deceleration strip's safety color is more effective to decelerate the vehicle than common strip for its vivid color and strong 3-dimension effect.%振动减速带是公路上常用的一种强制减速设施,对控制车辆车速,提升行车安全有重要作用.为了合理设置振动减速带,文中根据车辆行驶速度,以车辆竖向振动加速度为评价指标,对减速带外形进行优选;并利用错视觉原理对减速带的尺寸和色彩进行了新的设计.后期利用3D Studio Max软件制作视频,引入SD法(semantic differential method)对方案进行评价,结果表明振动减速带采用抛物线圆弧相切形状比圆弧形的竖向振动更小,行车舒适性更高;同时采用错视觉安全色,具有色彩鲜明、立体感强等特点,视觉减速效果显著优于普通减速带.

  14. ASACUSA's radio-frequency quadrupole decelerator, open to show the four-rod structure along the centre, which crosses 35 resonator chambers formed by the vertical partitions.

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    The Radio-Frequency Quadrupole, RFQD, which further decelerates antiprotons ejected from the Antiproton Decelerator (AD). Starting from a momentum of 100 MeV/c (kinetic energy 5.3 MeV), the RFQD delivers very-low-energy antiprotons, adjustable between 10 and 110 keV, to the experiment ASACUSA. In picture _02, the view from the upstream end shows its 4-rod structure, traversing 35 resonator chambers formed by the vertical partitions. The tank has an inner diameter of 390 mm and is pumped to a vacuum of a few E-8 Torr.

  15. Integrated solid-state nanopore platform for nanopore fabrication via dielectric breakdown, DNA-speed deceleration and noise reduction

    Science.gov (United States)

    Goto, Yusuke; Yanagi, Itaru; Matsui, Kazuma; Yokoi, Takahide; Takeda, Ken-Ichi

    2016-08-01

    The practical use of solid-state nanopores for DNA sequencing requires easy fabrication of the nanopores, reduction of the DNA movement speed and reduction of the ionic current noise. Here, we report an integrated nanopore platform with a nanobead structure that decelerates DNA movement and an insulating polyimide layer that reduces noise. To enable rapid nanopore fabrication, we introduced a controlled dielectric breakdown (CDB) process into our system. DNA translocation experiments revealed that single nanopores were created by the CDB process without sacrificing performance in reducing DNA movement speed by up to 10 μs/base or reducing noise up to 600 pArms at 1 MHz. Our platform provides the essential components for proceeding to the next step in the process of DNA sequencing.

  16. Subsonic pressure distributions around a solid model of an inflatable decelerator attached to the base of an ogive-cylinder

    Science.gov (United States)

    Sawyer, J. W.

    1972-01-01

    A wind-tunnel investigation was conducted at free-stream Mach numbers from 0.20 to 1.00 and corresponding Reynolds numbers, based on maximum afterbody diameter, from 2.25 x one million to 6.90 x one million on a solid model of an attached inflatable decelerator (AID) connected to the base of an ogive-cylinder. Tests were conducted to obtain ram-air and surface pressure distributions about the AID. AID shapes derived for subsonic deployment are dependent on the pressure distributions used in their derivation, and the different shapes obtained are dependent on the Mach number for which the design is made. The resulting pressure distributions were used in a design program to obtain new shapes which were compared with the original pressure-distribution shape.

  17. Decelerating the diminishing returns of citizenship on task performance: the role of social context and interpersonal skill.

    Science.gov (United States)

    Ellington, J Kemp; Dierdorff, Erich C; Rubin, Robert S

    2014-07-01

    Recent scholarship on citizenship behavior demonstrates that engaging too often in these behaviors comes at the expense of task performance. In order to examine the boundary conditions of this relationship, we used resource allocation and social exchange theories to build predictions regarding moderators of the curvilinear association between citizenship and task performance. We conducted a field study of 366 employees, in which we examined the relationship between the frequency of interpersonal helping behavior and task performance and tested for the moderating influences of 3 social context features (social density, interdependence, and social support) and of employees' levels of interpersonal skill. Results provided corroborating evidence of the diminishing returns between citizenship and task performance. Further, these diminishing returns were decelerated when contexts were characterized by high interdependence and social density and when employees possessed strong interpersonal skills. Implications for extending future citizenship theory and research to incorporate curvilinearity are presented.

  18. Design and optimisation of low heat load liquid helium cryostat to house cryogenic current comparator in antiproton decelerator at CERN

    Science.gov (United States)

    Lees, A.; Koettig, T.; Fernandes, M.; Tan, J.

    2017-02-01

    The Cryogenic Current Comparator (CCC) is installed in the low-energy Antiproton Decelerator (AD) at CERN to make an absolute measurement of the beam intensity. Operating below 4.2 K, it is based on a superconducting quantum interference device (SQUID) and employs a superconducting niobium shield to supress magnetic field components not linked to the beam current. The AD contains no permanent cryogenic infrastructure so the local continuous liquefaction of helium using a pulse-tube is required; limiting the available cooling power to 0.69 W at 4.2K. Due to the sensitivity of the SQUID to variations in magnetic fields, the CCC is highly sensitive to mechanical vibration which is limited to a minimum by the support systems of the cryostat. This article presents the cooling system of the cryostat and discusses the design challenges overcome to minimise the transmission of vibration to the CCC while operating within the cryogenic limits imposed by the cooling system.

  19. Measuring how game feel is influenced by the player avatar's acceleration and deceleration

    DEFF Research Database (Denmark)

    Dahl, Gustav; Kraus, Martin

    2015-01-01

    The feel of videogames is important, but not very well understood. Game feel is an integral part of game design and can be defined as the moment-to-moment sensation of control in games. It is important for game designers to understand when a game feels a certain way, since it is something...... that the player is constantly experiencing. There is a need of a better understanding of why certain games feel like they do, such as which parameters can be used to make a game feeling a particular way. This paper sets out to investigate what words players use to describe the feel of games, as well as what kind...... of parameters yield these descriptive words. This is attempted by using a 2D platforming game in which the response of the player avatar's motion is modulated. Between each round, players were asked to describe their perceived feel of controlling the avatar. The majority used basic words to describe the feel...

  20. Passive Thermal Control for the Low Density Supersonic Decelerator (LDSD) Test Vehicle Spin Motors Sub-System

    Science.gov (United States)

    Redmond, Matthew; Mastropietro, A. J.; Pauken, Michael; Mobley, Brandon

    2014-01-01

    Future missions to Mars will require improved entry, descent, and landing (EDL) technology over the Viking-heritage systems which recently landed the largest payload to date, the 900 kg Mars Science Laboratory. As a result, NASA's Low Density Supersonic Decelerator (LDSD) project is working to advance the state of the art in Mars EDL systems by developing and testing three key technologies which will enable heavier payloads and higher altitude landing sites on the red planet. These technologies consist of a large 33.5 m diameter Supersonic Disk Sail (SSDS) parachute and two different Supersonic Inflatable Aerodynamic Decelerator (SIAD) devices - a robotic class that inflates to a 6 m diameter torus (SIAD-R), and an exploration class that inflates to an 8 m diameter isotensoid (SIADE). All three technologies will be demonstrated on test vehicles at high earth altitudes in order to simulate the Mars EDL environment. Each vehicle will be carried to altitude by a large helium balloon, released, spun up using spin motors to stabilize the vehicle's trajectory, and accelerated to supersonic speeds using a large solid rocket motor. The vehicle will then be spun down using another set of spin motors, and will deploy either the SIAD-R or SIAD-E, followed by the SSDS parachute until the vehicle lands in the ocean. Component level testing and bounding analysis are used to ensure the survival of system components in extreme thermal environments and predict temperatures throughout the flight. This paper presents a general description of the thermal testing, model correlation, and analysis of the spin motor passive thermal control sub-system to maintain spin motor performance, prescribed vehicle trajectory, and structural integrity of the test vehicle. The spin motor subsystem is predicted to meet its requirements with margin.

  1. Passive Thermal Control for the Low Density Supersonic Decelerator (LDSD) Test Vehicle Spin Motors Sub-System

    Science.gov (United States)

    Redmond, Matthew; Mastropietro, A. J.; Pauken, Michael; Mobley, Brandon

    2014-01-01

    Future missions to Mars will require improved entry, descent, and landing (EDL) technology over the Viking-heritage systems which recently landed the largest payload to date, the 900 kg Mars Science Laboratory. As a result, NASA's Low Density Supersonic Decelerator (LDSD) project is working to advance the state of the art in Mars EDL systems by developing and testing three key technologies which will enable heavier payloads and higher altitude landing sites on the red planet. These technologies consist of a large 33.5 m diameter Supersonic Disk Sail (SSDS) parachute and two different Supersonic Inflatable Aerodynamic Decelerator (SIAD) devices - a robotic class that inflates to a 6 m diameter torus (SIAD-R), and an exploration class that inflates to an 8 m diameter isotensoid (SIADE). All three technologies will be demonstrated on test vehicles at high earth altitudes in order to simulate the Mars EDL environment. Each vehicle will be carried to altitude by a large helium balloon, released, spun up using spin motors to stabilize the vehicle's trajectory, and accelerated to supersonic speeds using a large solid rocket motor. The vehicle will then be spun down using another set of spin motors, and will deploy either the SIAD-R or SIAD-E, followed by the SSDS parachute until the vehicle lands in the ocean. Component level testing and bounding analysis are used to ensure the survival of system components in extreme thermal environments and predict temperatures throughout the flight. This paper presents a general description of the thermal testing, model correlation, and analysis of the spin motor passive thermal control sub-system to maintain spin motor performance, prescribed vehicle trajectory, and structural integrity of the test vehicle. The spin motor subsystem is predicted to meet its requirements with margin.

  2. Hydrocephalus in mice following X-irradiation at early gestational stage. Possibly due to persistent deceleration of cell proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Aolad, H.M.; Inouye, Minoru; Darmanto, W.; Hayasaka, Shizu; Murata, Yoshiharu [Nagoya Univ. (Japan). Research Inst. of Environmental Medicine

    2000-09-01

    The pathogenesis of X-ray-induced congenital hydrocephalus was studied. Pregnant mice were irradiated at 1.4 Gy on gestational day 7 (G7). Four hours after irradiation, extensive cell death was evident in the neuroepithelium and underlying mesoderm of the head region, and proliferating cell nuclear antigen (PCNA)-immunoreactive cells almost disappeared. Embryos with thinner lamina terminalis of the telecephalon, when compared with that of the control, were found in the irradiated group on G9. As early as G11 in some irradiated embryos the telencephalic wall was thinner and lateral ventricles were larger than those of the control. The choroid invagination from the lamina terminalis began on G11 in the control brain, but not in the affected brain. During the following development, fetuses with readily apparent hydrocephalus were consistently found among irradiated fetuses. In these brains the brain mantle was thinner, the corpus striatum and thalamic regions were smaller, and lateral ventricles were larger than those of the control. Even on G11 and G13 the frequencies of PCNA-positive cells in the brain mantle and other brain regions were lower in the hydrocephalic brain than those of the control, suggesting a decelerated proliferation of successive cell generations following exposure to X-rays. The cerebral aqueduct was open in the hydrocephalic brain during the fetal period when the lateral ventricles were dilated. The head was vaulted after birth but the cerebral aqueduct was not completely occluded even in these animals. These findings suggested that cell death in the neuroepithelium followed by a persistent deceleration of neural cell proliferation, resulting in the hypoplasia of brain parenchyma with compensatory ventricular dilatation, is important for the establishment of hydrocephalus. (author)

  3. 脉搏指示连续心排血量技术对压力与容量控制模式机械通气容量参数的影响%Influence of pulse indicator continuous cardiac output in monitoring on the volume parameters of different tidal volume under pressure control ventilation mode and volume-controlled ventilation mode in sheep

    Institute of Scientific and Technical Information of China (English)

    李军; 高心晶; 高艳颖; 卫俊涛; 秦英智

    2010-01-01

    Objective To compare the influence of pulse indicator continuous cardiac output(PiCCO)in monitoring tidal volume(V_T)under pressure control ventilation mode and volume-controlled ventilation mode in sheep.Methods After anesthesia and tracheotomy,5 sheep,which were apneic and receiving mechanical ventilation.Twenty minutes later,central venous pressure(CVP)and cardiac function were monitored with different selected V_T levels of 6,10,15,20 ml/kg under bi-level positive airway pressure (BiPAP)mode by changing the pressure of inspiration,or under the synchronized intermittent mandatory ventilation(SIMV)mode with the same ventilation conditions.Results In both modes,the increase in V_T led to an decrease of cardiac index(CI)and intrathoracic blood volume index(ITBVI),reaching a statistically significant difference at 15 ml/kg[SIMV mode:CI(3.94±1.03)L·min~(-1)·m~(-2),ITBVI (707±105)ml/m2;BiPAP mode:CI(4.11±1.11)L·min-1±m-2,ITBVI(715±122)ml/m2]and 20 ml/kg[SIMV mode:CI(3.87±1.04)L·min~(-1)·m~(-2),ITBVI(705±116)ml/m2;BiPAP mode:CI (3.64±0.96)L·min~(-1)·m~(-2),ITBVI(694±114)ml/m2]compared with 6 ml/kg[SIMV mode:CI (4.96±1.58)L·min~(-1)·m~(-2),ITBVI(811±169)ml/m2;BiPAP mode:CI(5.67±1.96)L·min~(-1)·m~(-2),ITBVI(8234-182)ml/m~2,all P<0.05];an increase in systemic vascular resistance index(SVRI)and mean airway pressure(Pmean)at 15 ml/kg[SIMV mode:SVRI(237.64±6.2)kPa·s~(-1)·L~(-1),Pmean(14.0±3.2)cm H2O(1 cm H2O=0.098 kPa);BiPAP mode:SVRI(230.8±32.9)kPa·s~(-1)·L~(-1),Pmean(13.0±2.2)cm H_2O]and 20 ml/kg[SIMV mode:SVRI(253.1±76.7)kPa·s~(-1)·L~(-1),Pmean(18.2±4.8)cm H_2O;BiPAP mode:SVRI(246.7±48.8)kPa·s~(-1)·L~(-1),Pmean(16.8±3.3)cm H_2O]compared with 6 ml/kg[SIMV mode:SVRI(184.8±47.5)kPa·s~(-1)·L~(-1);Pmean(8.8±1.6)cm H_2O;BiPAP mode:SVRI(184.5±51.5)kPa·s~(-1)·L~(-1),Pmean(8.6±0.5)cm H_2O,all P<0.05];but there was no significant effects on CVP,heart rate(HR),mean blood pressure(MBP).There was no significant difference of CI

  4. Articulatory Parameters.

    Science.gov (United States)

    Ladefoged, Peter

    1980-01-01

    Summarizes the 16 parameters hypothesized to be necessary and sufficient for linguistic phonetic specifications. Suggests seven parameters affecting tongue shapes, three determining the positions of the lips, one controlling the position of the velum, four varying laryngeal actions, and one controlling respiratory activity. (RL)

  5. Parameter Estimation

    DEFF Research Database (Denmark)

    Sales-Cruz, Mauricio; Heitzig, Martina; Cameron, Ian;

    2011-01-01

    of optimisation techniques coupled with dynamic solution of the underlying model. Linear and nonlinear approaches to parameter estimation are investigated. There is also the application of maximum likelihood principles in the estimation of parameters, as well as the use of orthogonal collocation to generate a set...

  6. Exploration of the hydrogen producing potential of Rhodobacter capsulatus chemostat cultures: The application of deceleration-stat and gradient-stat methodology

    NARCIS (Netherlands)

    Hoekema, S.; Breukelen, van F.R.; Janssen, M.G.J.; Tramper, J.; Wijffels, R.H.

    2009-01-01

    In this work, the dependency of the volumetric hydrogen production rate of ammonium-limited Rhodobacter capsulatus chemostat cultures on their imposed biomass concentration and dilution rate was investigated. A deceleration-stat experiment was performed by lowering the dilution rate from 1.0 d-1 to

  7. Exploration of the hydrogen producing potential of Rhodobacter capsulatus chemostat cultures: The application of deceleration-stat and gradient-stat methodology

    NARCIS (Netherlands)

    Hoekema, S.; Breukelen, van F.R.; Janssen, M.G.J.; Tramper, J.; Wijffels, R.H.

    2009-01-01

    In this work, the dependency of the volumetric hydrogen production rate of ammonium-limited Rhodobacter capsulatus chemostat cultures on their imposed biomass concentration and dilution rate was investigated. A deceleration-stat experiment was performed by lowering the dilution rate from 1.0 d-1 to

  8. A Study of Transition of the Expansion of the Universe from a Phase of Deceleration to Acceleration through a Conversion of Matter into Dark Energy in the Framework of Brans-Dicke Theory

    CERN Document Server

    Roy, Sudipto

    2015-01-01

    The present study is based on a generalized form of Brans-Dicke (BD) theory where, the dimensionless BD parameter is regarded as a function of the scalar field, which is reciprocal of the gravitational constant. The field equations have been solved by incorporating an empirical function f(t) in the expression representing the conservation of matter. This function f(t) has been chosen to account for a conversion of matter (both dark and baryonic) into some other form, possibly dark energy, which is known to be responsible for the accelerated expansion of universe. The requirement of a signature flip of the deceleration parameter (q), which is evident from other studies, sets the boundary conditions to be satisfied by the function f(t), leading to the formulation of its time dependence. A simple empirical relation was initially assumed to represent the time dependence of f(t), and the constants in this expression have been determined from these boundary conditions. The BD parameter has been found to have a nega...

  9. Inventory parameters

    CERN Document Server

    Sharma, Sanjay

    2017-01-01

    This book provides a detailed overview of various parameters/factors involved in inventory analysis. It especially focuses on the assessment and modeling of basic inventory parameters, namely demand, procurement cost, cycle time, ordering cost, inventory carrying cost, inventory stock, stock out level, and stock out cost. In the context of economic lot size, it provides equations related to the optimum values. It also discusses why the optimum lot size and optimum total relevant cost are considered to be key decision variables, and uses numerous examples to explain each of these inventory parameters separately. Lastly, it provides detailed information on parameter estimation for different sectors/products. Written in a simple and lucid style, it offers a valuable resource for a broad readership, especially Master of Business Administration (MBA) students.

  10. Analysis of the structural parameters that influence gas production from the Devonian shale. Annual progress report, 1979-1980. Volume II. Data repository and reports published during fiscal year 1979-1980: regional structure, surface structure, surface fractures, hydrology

    Energy Technology Data Exchange (ETDEWEB)

    Negus-De Wys, J.; Dixon, J. M.; Evans, M. A.; Lee, K. D.; Ruotsala, J. E.; Wilson, T. H.; Williams, R. T.

    1980-10-01

    This volume comprises appendices giving regional structure data, surface structure data, surface fracture data, and hydrology data. The fracture data covers oriented Devonian shale cores from West Virginia, Ohio, Virginia, Pennsylvania, and Kentucky. The subsurface structure of the Eastern Kentucky gas field is also covered. (DLC)

  11. Analysis of deceleration capacity of heart rate and heart rate variability in patients with diabetes%糖尿病患者心率减速力与心率变异性分析

    Institute of Scientific and Technical Information of China (English)

    薛妮娜; 吴岳平

    2012-01-01

    Objectives To investigate the application of deceleration capacity of heart rate (DC) and heart rate variability (HRV) to evaluating autnnomic nervous function in patients with type 2 diabetes. Methods An amount of 73 patients with type 2 diabetes and 65 normal control subjects underwent 24-hour dynamic electrocardiogram recordings. DC and time-domain HRV parameters were obtained through off-line calculation, compared and analyzed. Results DC and time-domain HRV parameters in patients with type 2 diabetes were significantly lower than those in control group (P< 0.05). DC was positively correlated with SDNN (r=0.597,P<0.01), RMSSD (r=0.569, P<0.01), pNN50 (r=0.501, P<0.05). Conclusions DC can be considered as an indicator for autonomic nervous function test in patients with type 2 diabetes, and it is positively correlated with time-domain HRV parameters.%目的 探讨心率减速力(deceleration capacity of hear rate,DC)与心率变异性(heart rate variability,HRV)在评价糖尿病患者自主神经功能方面的应用.方法 对73例2型糖尿病患者和65名正常人群对照组进行24 h动态心电图检查,离线计算DC、HRV时域指标并进行比较和相关分析.结果 2型糖尿病患者的DC及HRV各时域指标均比对照组降低,差异均有统计学意义(P<0.05).相关分析结果显示,2型糖尿病组DC与HRV中的总标准差(SDNN)呈正相关(r=0.597,P<0.01),与差值均方根(RMSSD)呈正相关(r=0.569,P<0.01),与pNN50呈正相关(r=0.501,P<0.05).结论 DC和HRV各时域指标有较好的相关性,可作为2型糖尿病患者自主神经功能检测的指标.

  12. The E-wave deceleration rate E/DT outperforms the tissue Doppler-derived index E/e' in characterizing lung remodeling in heart failure with preserved ejection fraction.

    Directory of Open Access Journals (Sweden)

    T Dung Nguyen

    Full Text Available BACKGROUND: Diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF may result in pulmonary congestion and lung remodeling. We evaluated the usefulness of major diastolic echocardiographic parameters and of the deceleration rate of early transmitral diastolic velocity (E/DT in predicting lung remodeling in a rat model of HFpEF. METHODS AND RESULTS: Rats underwent aortic banding (AoB to induce pressure overload (PO. Left ventricular hypertrophy fully developed 2 weeks after AoB. At 4 and 6 weeks, the lung weight-to-body weight ratio (LW/BW, a sensitive marker for pulmonary congestion and remodeling, dramatically increased despite preserved fractional shortening, indicating the presence of HFpEF. The time course of LW/BW was well reflected by E/DT, by the ratio of early to late transmitral diastolic velocity (E/A and the deceleration time of E (DT, but not by the ratio of transmitral to mitral annular early diastolic velocity (E/e'. In agreement, the best correlation with LW/BW was found for E/DT (r = 0.76; p<0.0001, followed by E/A (r = 0.69; p<0.0001, DT (r = -0.62; p<0.0001 and finally E/e' (r = 0.51; p<0.001. Furthermore, analysis of receiver-operating characteristic curves for the prediction of increased LW/BW revealed excellent area under the curve values for E/DT (AUC = 0.98 and DT (AUC = 0.95, which are significantly higher than that of E/e' (AUC = 0.82. In a second approach, we also found that the new parameter E/DT correlated well with right ventricular weight index and echocardiographic measures of right ventricular systolic function. CONCLUSIONS: The novel parameter E/DT outperforms the tissue Doppler index E/e' in detecting and monitoring lung remodeling induced by pressure overload. The results may provide a handy tool to point towards secondary lung disease in HFpEF and warrant further clinical investigations.

  13. Testing single-parameter classical standpoint cosmology

    CERN Document Server

    Chew, Geoffrey Foucar

    1995-01-01

    Experimental tests of homogeneous-universe classical standpoint cosmology are proposed after presentation of conceptual considerations that encourage this radical departure from the standard model. Among predictions of the new model are standpoint age equal to Hubble time, energy-density parameter \\Omega_0 = 2 - \\sqrt{2} =.586, and relations between redshift, Hubble-scale distribution of matter and galaxy luminosity and angular diameter. These latter relations coincide with those of the standard model for zero deceleration. With eye to further tests, geodesics of the non-Riemannian standpoint metric are explicitly given. Although a detailed thermodynamic ``youthful-standpoint'' approximation remains to be developed (for particle mean free path small on standpoint scale), standpoint temperature depending only on standpoint age is a natural concept, paralleling energy density and redshift that perpetuates thermal spectrum for cosmic background radiation. Prospects for primordial nucleosynthesis are promising.

  14. Slowing and cooling of heavy or light (even with a tiny electric dipole moment) polar molecules using a novel, versatile electrostatic Stark decelerator.

    Science.gov (United States)

    Wang, Qin; Hou, Shunyong; Xu, Liang; Yin, Jianping

    2016-02-21

    To meet some demands for realizing precise measurements of an electric dipole moment of electron (eEDM) and examining cold collisions or cold chemical physics, we have proposed a novel, versatile electrostatic Stark decelerator with an array of true 3D electric potential wells, which are created by a series of horizontally-oriented, U-shaped electrodes with time-sequence controlling high voltages (± HV) and two guiding electrodes with a constant voltage. We have calculated the 2D electric field distribution, the Stark shifts of the four lowest rotational sub-levels of PbF molecules in the X1(2)Π1/2(v = 0) electronic and vibrational ground states as well as the population in the different rotational levels. We have discussed the 2D longitudinal and transverse phase-space acceptances of PbF molecules in our decelerator. Subsequently, we have simulated the dynamic processes of the decelerated PbF molecules using the 3D Monte-Carlo method, and have found that a supersonic PbF beam with a velocity of 300 m s(-1) can be efficiently slowed to about 5 m s(-1), which will greatly enhance the sensitivities to research a parity violation and measure an eEDM. In addition, we have investigated the dependences of the longitudinal velocity spread, longitudinal temperature and bunching efficiency on both the number of guiding stages and high voltages, and found that after bunching, a cold packet of PbF molecules in the J = 7/2, MΩ = -7/4 state with a longitudinal velocity spread of 0.69 m s(-1) (corresponding to a longitudinal temperature of 2.35 mK) will be produced by our high-efficient decelerator, which will generate a high energy-resolution molecular beam for studying cold collision physics. Finally, our novel decelerator can also be used to efficiently slow NO molecules with a tiny electric dipole moment (EDM) of 0.16 D from 315 m s(-1) to 28 m s(-1). It is clear that our proposed new decelerator has a good slowing performance and experimental feasibility as well as wide

  15. Age-related differences in postural control in humans in response to a sudden deceleration generated by postural disturbance.

    Science.gov (United States)

    Okada, S; Hirakawa, K; Takada, Y; Kinoshita, H

    2001-07-01

    Age-related differences in postural control in response to a relatively large deceleration resulting from postural disturbance were investigated in eight normal elderly men (age range 67-72 years) and eight young men as controls (age range 19-22 years) using a moving platform. Data were obtained for the hip, knee and ankle angles, position of the centre of foot pressure (CFP), head acceleration, and muscle activity of the leg muscles. The elderly subjects had slower and larger ankle and hip joint movements, and CFP displacement in response to the disturbance compared to the young controls. The elderly subjects also had a delayed occurrence, and greater magnitude of peak acceleration of head rotation than did the young subjects. For the elderly subjects, the CFP was closely related to angular changes in the hip joint movement, but not to those of the ankle and knee joint movements. For the young subjects, on the other hand, the CFP was significantly correlated with angular change in the ankle joint. Cocontraction of the tibialis anterior and gastrocnemius muscles was observed in the elderly subjects. The results indicated that a movement pattern for postural correction in the elderly adults was different from that of the young adults. The elderly relied more on hip movements while the young controls relied on ankle movements to control postural stability.

  16. First Observational Signature of Rotational Deceleration in a Massive, Intermediate-age Star Cluster in the Magellanic Clouds

    CERN Document Server

    Wu, Xiaohan; de Grijs, Richard; Deng, Licai

    2016-01-01

    While the extended main-sequence turn-offs (eMSTOs) found in almost all 1--2 Gyr-old star clusters in the Magellanic Clouds are often explained by postulating extended star-formation histories, the tight subgiant branches (SGBs) seen in some clusters challenge this popular scenario. Puzzlingly, the SGB of the eMSTO cluster NGC 419 is significantly broader at bluer than at redder colors. We carefully assess and confirm the reality of this observational trend. If we would assume that the widths of the features in color--magnitude space were entirely owing to a range in stellar ages, the star-formation histories of the eMSTO stars and the blue SGB region would be significantly more prolonged than that of the red part of the SGB. This cannot be explained by assuming an internal age spread. We show that rotational deceleration of a population of rapidly rotating stars, a currently hotly debated alternative scenario, naturally explains the observed trend along the SGB. Our analysis shows that a `converging' SGB cou...

  17. Independent Orbiter Assessment (IOA): Assessment of the landing/deceleration (LDG/DEC) subsystem FMEA/CIL

    Science.gov (United States)

    Odonnell, R. A.; Weissinger, D.

    1988-01-01

    The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. The IOA effort first completed an analysis of the Landing/Deceleration (LDG/DEC) hardware, generating draft failure modes and potential critical items. To preserve independence, this analysis was accomplished without reliance upon the results contained within the NASA FMEA/CIL documentation. The IOA contained within the NASA FMEA/CIL documentation. The IOA results were then compared to the NASA FMEA/CIL baseline with proposed Post 51-L updates included. A resolution of each discrepancy from the comparison is provided through additional analysis as required. This report documents the results of that comparison for the Orbiter LDG/DEC hardware. The IOA product for the LDG/DEC analysis consisted of 259 failure mode worksheets that resulted in 124 potential critical items being identified. Comparison was made to the NASA baseline which consisted of 267 FMEA's and 120 CIL items. This comparison produced agreement on all but 75 FMEA's which caused differences in 51 CIL items.

  18. Cavity-induced phase stability to decelerate a fast molecular beam via feedback-controlled time-varying optical pumps

    CERN Document Server

    Lan, Zhihao

    2014-01-01

    We have identified a novel phase stability mechanism from the intracavity field-induced self-organization of a fast-moving molecular beam into travelling molecular packets in the bad cavity regime, which is then used to decelerate the molecular packets by feedback-controlled time-varying laser pumps to the cavity. We first applied the linear stability analysis to derive an expression for this self-organization in the adiabatic limit and show that the self-organization of the beam leads to the formation of travelling molecular packets, which in turn function as a dynamic Bragg grating, thus modulating periodically the intracavity field by superradiant scattering of the pump photons. The modulation encodes the position information of the molecular packets into the output of the intracavity field instantaneously. We then applied time-varying laser pumps that are automatically switched by the output of the intracavity field to slow down the molecular packets via a feedback mechanism and found that most of the mol...

  19. A decelerating jet observed by the EVN and VLBA in the X-ray transient XTE J1752-223

    CERN Document Server

    Yang, J; Corbel, S; Paragi, Z; Tzioumis, T; Fender, R P

    2010-01-01

    The recently discovered Galactic X-ray transient XTE J1752-223 entered its first known outburst in 2010, emitting from the X-ray to the radio regimes. Its general X-ray properties were consistent with those of a black hole candidate in various spectral states, when ejection of jet components is expected. To verify this, we carried out very long baseline interferometry (VLBI) observations. The measurements were carried out with the European VLBI Network (EVN) and the Very Long Baseline Array (VLBA) at four epochs in 2010 February. The images at the first three epochs show a moving jet component that is significantly decelerated by the last epoch, when a new jet component appears that is likely to be associated with the receding jet side. The overall picture is consistent with an initially mildly relativistic jet, interacting with the interstellar medium or with swept-up material along the jet. The brightening of the receding ejecta at the final epoch can be well explained by initial Doppler deboosting of the e...

  20. Echocardiographic predictors of early in-hospital heart failure during first ST-elevation acute myocardial infarction: does myocardial performance index and left atrial volume improve diagnosis over conventional parameters of left ventricular function?

    Directory of Open Access Journals (Sweden)

    Machado Cristiano V

    2011-06-01

    Full Text Available Abstract Background Left ventricular ejection fraction (LVEF has been considered a major determinant of early outcome in acute myocardial infarction (AMI. Myocardial performance index (MPI has been associated to early evolution in AMI in a heterogeneous population, including non ST-elevation or previous AMI. Left atrial volume has been related with late evolution after AMI. We evaluated the independent role of clinical and echocardiographic variables including LVEF, MPI and left atrial volume in predicting early in-hospital congestive heart failure (CHF specifically in patients with a first isolated ST-elevation AMI. Methods Echocardiography was performed within 30 hours of chest pain in 95 patients with a first ST-elevation AMI followed during the first week of hospitalization. Several clinical and echocardiographic variables were analyzed. CHF was defined as Killip class ≥ II. Multivariate regression analysis was used to select independent predictor of in-hospital CHF. Results Early in-hospital CHF occurred in 29 (31% of patients. LVEF ≤ 0.45 was the single independent and highly significant predictor of early CHF among other clinical and echocardiographic variables (odds ratio 17.0; [95% CI 4.1 - 70.8]; p Conclusion For patients with first, isolated ST-elevation AMI, LVEF assessed by echocardiography still constitutes a strong and accurate independent predictor of early in-hospital CHF, superior to isolated MPI and left atrial volume in this particular subset of patients.

  1. Renormalized Volume

    Science.gov (United States)

    Gover, A. Rod; Waldron, Andrew

    2017-09-01

    We develop a universal distributional calculus for regulated volumes of metrics that are suitably singular along hypersurfaces. When the hypersurface is a conformal infinity we give simple integrated distribution expressions for the divergences and anomaly of the regulated volume functional valid for any choice of regulator. For closed hypersurfaces or conformally compact geometries, methods from a previously developed boundary calculus for conformally compact manifolds can be applied to give explicit holographic formulæ for the divergences and anomaly expressed as hypersurface integrals over local quantities (the method also extends to non-closed hypersurfaces). The resulting anomaly does not depend on any particular choice of regulator, while the regulator dependence of the divergences is precisely captured by these formulæ. Conformal hypersurface invariants can be studied by demanding that the singular metric obey, smoothly and formally to a suitable order, a Yamabe type problem with boundary data along the conformal infinity. We prove that the volume anomaly for these singular Yamabe solutions is a conformally invariant integral of a local Q-curvature that generalizes the Branson Q-curvature by including data of the embedding. In each dimension this canonically defines a higher dimensional generalization of the Willmore energy/rigid string action. Recently, Graham proved that the first variation of the volume anomaly recovers the density obstructing smooth solutions to this singular Yamabe problem; we give a new proof of this result employing our boundary calculus. Physical applications of our results include studies of quantum corrections to entanglement entropies.

  2. Correlation and assessment of structural airplane crash data with flight parameters at impact

    Science.gov (United States)

    Carden, H. D.

    1982-01-01

    Crash deceleration pulse data from a crash dynamics program on general aviation airplanes and from transport crash data were analyzed. Structural airplane crash data and flight parameters at impact were correlated. Uncoupled equations for the normal and longitudinal floor impulses in the cabin area of the airplane were derived, and analytical expressions for structural crushing during impact and horizontal slide out were also determined. Agreement was found between experimental and analytical data for general aviation and transport airplanes over a relatively wide range of impact parameter. Two possible applications of the impulse data are presented: a postcrash evaluation of crash test parameters and an assumed crash scenario.

  3. LLE review: Quarterly report, July--September 1995. Volume 64

    Energy Technology Data Exchange (ETDEWEB)

    Craxton, R.S. [ed.

    1995-09-01

    This volume of the LLE Review, covering the period July--September 1995, includes a description of the first target experiments performed on the upgraded OMEGA laser system. These experiments, carried out to active and test several diagnostics systems, have demonstrated successful functioning of the overall experimental system and have produced high neutron yields and high core temperatures. Other articles in this volume describe the diagnosis of core conditions using krypton line spectroscopy, a mix model for LILAC that can be applied to study the deceleration instability at the pusher-core interface, a simulated-annealing algorithm for improved phase-plate design, a simple method for characterizing the thickness and uniformity of transparent laser-fusion targets, and femtosecond pump-probe experiments on semiconducting YBCO.

  4. A Symmetrical Linear Acceleration and Deceleration Control Method%一种对称式直线加减速方法

    Institute of Scientific and Technical Information of China (English)

    黄昭县; 王志成

    2014-01-01

    在高速高精加工中,定位时间和定位精度是衡量数控系统性能的两项重要指标。论文分析了传统直线加减速中定位时间较长的原因,在此基础上提出了采用对称思想使减速段与加速段严格对称的改进方法,并进行了仿真和实验。结果表明在保证精度的前提下,采用该方法可以缩短定位时间,能够提高定位效率。%In high-speed and high-precision processing industry, the positioning time and positioning accura-cy are the most important indicators in measured the performance of CNC machine tools . The reasons of po-sitioning time longer in the traditional linear acceleration and deceleration control is analyzed. On this basis, it puts forward an improved linear acceleration and deceleration control methods whose deceleration and ac-celeration segments are strictly symmetrical and carries out simulation and experiment. The results show that this method can shorten the positioned time and improve the positioning efficiency under the premise of ensu-ring accuracy.

  5. Moduli stabilization, large-volume dS minimum without D3-branes, (non-)supersymmetric black hole attractors and two-parameter Swiss cheese Calabi–Yau’s

    CERN Document Server

    Misra, A

    2008-01-01

    We consider two sets of issues in this paper. The first has to do with moduli stabilization, existence of “area codes” [A. Giryavets, New attractors and area codes, JHEP 0603 (2006) 020, hep-th/0511215] and the possibility of getting a non-supersymmetric dS minimum without the addition of -branes as in KKLT for type II flux compactifications. The second has to do with the “inverse problem” [K. Saraikin, C. Vafa, Non-supersymmetric black holes and topological strings, hep-th/0703214] and “fake superpotentials” [A. Ceresole, G. Dall'Agata, Flow equations for non-BPS extremal black holes, JHEP 0703 (2007) 110, hep-th/0702088] for extremal (non-)supersymmetric black holes in type II compactifications. We use (orientifold of) a “Swiss cheese” Calabi–Yau [J.P. Conlon, F. Quevedo, K. Suruliz, Large-volume flux compactifications: Moduli spectrum and D3/D7 soft supersymmetry breaking, JHEP 0508 (2005) 007, hep-th/0505076] expressed as a degree-18 hypersurface in WCP4[1,1,1,6,9] in the “large-volume...

  6. 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures

    Science.gov (United States)

    Papaevgeniou, Nikoletta; Sakellari, Marianthi; Jha, Sweta; Tavernarakis, Nektarios; Holmberg, Carina I.; Gonos, Efstathios S.

    2016-01-01

    Abstract Aims: Proteasomes are constituents of the cellular proteolytic networks that maintain protein homeostasis through regulated proteolysis of normal and abnormal (in any way) proteins. Genetically mediated proteasome activation in multicellular organisms has been shown to promote longevity and to exert protein antiaggregation activity. In this study, we investigate whether compound-mediated proteasome activation is feasible in a multicellular organism and we dissect the effects of such approach in aging and Alzheimer's disease (AD) progression. Results: Feeding of wild-type Caenorhabditis elegans with 18α-glycyrrhetinic acid (18α-GA; a previously shown proteasome activator in cell culture) results in enhanced levels of proteasome activities that lead to a skinhead-1- and proteasome activation-dependent life span extension. The elevated proteasome function confers lower paralysis rates in various AD nematode models accompanied by decreased Aβ deposits, thus ultimately decelerating the progression of AD phenotype. More importantly, similar positive results are also delivered when human and murine cells of nervous origin are subjected to 18α-GA treatment. Innovation: This is the first report of the use of 18α-GA, a diet-derived compound as prolongevity and antiaggregation factor in the context of a multicellular organism. Conclusion: Our results suggest that proteasome activation with downstream positive outcomes on aging and AD, an aggregation-related disease, is feasible in a nongenetic manipulation manner in a multicellular organism. Moreover, they unveil the need for identification of antiaging and antiamyloidogenic compounds among the nutrients found in our normal diet. Antioxid. Redox Signal. 25, 855–869. PMID:26886723

  7. Lyn Evans decelerates!

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    After more than 40 years at CERN, 15 of which were dedicated to ensuring that the LHC comes to completion, Lyn Evans is retiring. The Imperial College Professor and recently-elected Fellow of the British Royal Society has set himself new challenges, but plans to keep strong links with CERN. His big thank you goes to the many hundreds of people who built one of the most complex scientific instruments ever conceived by mankind. Note from the Editor: It is unusual for the Bulletin to adopt a question-and-answer style. However, we recognise that, with someone of Lyn’s stature, the appropriate thing to do is simply to give him the floor. Bulletin: Lyn, are you really leaving CERN? I am retiring but I will not completely lose contacts with CERN and the LHC. It’s time to slow down for me now but I will join the CMS Collaboration. I will help with the link between the experiment and the machine. Bulletin: After many years as LHC Project Manager...

  8. Biodegradable Sonobuoy Decelerators

    Science.gov (United States)

    2015-06-01

    Standard Specification for Non-Floating Biodegradable Plastics in the Marine Environment. Results showed that no PHA grades were toxic to the marine...accordance with ASTM D6691 “Standard Test Method for Determining Aerobic Biodegradation of Plastics Materials in the Marine Environment by a Defined...the biodegradation of a polymer vs. a stand- alone weight loss test. Biodegradation rates as high as these are rare for plastics in the marine

  9. Supergranular Parameters

    Science.gov (United States)

    Udayashankar, Paniveni

    2016-07-01

    I study the complexity of supergranular cells using intensity patterns from Kodaikanal solar observatory. The chaotic and turbulent aspect of the solar supergranulation can be studied by examining the interrelationships amongst the parameters characterizing supergranular cells namely size, horizontal flow field, lifetime and physical dimensions of the cells and the fractal dimension deduced from the size data. The findings are supportive of Kolmogorov's theory of turbulence. The Data consists of visually identified supergranular cells, from which a fractal dimension 'D' for supergranulation is obtained according to the relation P α AD/2 where 'A' is the area and 'P' is the perimeter of the supergranular cells. I find a fractal dimension close to about 1.3 which is consistent with that for isobars and suggests a possible turbulent origin. The cell circularity shows a dependence on the perimeter with a peak around (1.1-1.2) x 105 m. The findings are supportive of Kolmogorov's theory of turbulence.

  10. Variations in clinical estimates of tumor volume regression parameters and time factor during external radiotherapy in cancer cervix: Does it mimic the linear-quadratic model of cell survival?

    Directory of Open Access Journals (Sweden)

    Datta N

    2005-01-01

    Full Text Available BACKGROUND: Tumor regression parameters and time factor during external radiotherapy (EXTRT are of paramount importance. AIMS: To quantify the parameters of tumor regression and time factor during EXTRT in cancer cervix. SETTINGS AND DESIGN: Patients, treated solely with radiotherapy and enrolled for other prospective studies having weekly tumor regressions recorded were considered. MATERIALS AND METHODS: Seventy-seven patients received 50Gy of EXTRT followed by intracavitary brachytherapy. Loco-regional regressions were assessed clinically and regression fraction (RF was represented as RF = c + a1D + a2D2- a3T, with c, D and T as constant, cumulative EXTRT dose and treatment time respectively. STATISTICAL ANALYSIS USED: Step wise linear regression was performed for RF. Scatter plots were fitted using linear-quadratic fit. RESULTS: Coefficients of parameters D, D2 and T were computed for various dose intervals, namely 0-20 Gy, 0-30 Gy, 0-40 Gy and 0-50 Gy. At 0-20 Gy and 0-30 Gy, only the coefficient of D2 was significant (P < 0.001, while both D2 and T turned significant (P < 0.001 at 0-40 Gy. For the entire range of 0-50 Gy, all the coefficients of D, D2 and T showed significance, leading to an estimate of 26 Gy for a1/a2 and 0.96 Gy/day for a3/a1. CONCLUSIONS: As with a/β and g/a of post-irradiation cell survival curves, a1/a2 and a3/a1 represents the cumulative effect of various radiobiological factors influencing clinical regression of tumor during the course of EXTRT. The dynamic changes in the coefficients of D, D2sub and T, indicate their relative importance during various phases of EXTRT.

  11. Moduli stabilization, large-volume dS minimum without D3{sup -bar} -branes, (non-)supersymmetric black hole attractors and two-parameter Swiss cheese Calabi-Yau's

    Energy Technology Data Exchange (ETDEWEB)

    Misra, Aalok [Department of Physics, Indian Institute of Technology, Roorkee 247 667, Uttaranchal (India); Physics Department, Theory Unit, CERN, CH-1211 Geneva 23 (Switzerland)], E-mail: aalokfph@iitr.ernet.in; Shukla, Pramod [Department of Physics, Indian Institute of Technology, Roorkee 247 667, Uttaranchal (India)], E-mail: pmathdph@iitr.ernet.in

    2008-08-11

    We consider two sets of issues in this paper. The first has to do with moduli stabilization, existence of 'area codes' [A. Giryavets, New attractors and area codes, JHEP 0603 (2006) 020, (hep-th/0511215)] and the possibility of getting a non-supersymmetric dS minimum without the addition of D3-bar-branes as in KKLT for type II flux compactifications. The second has to do with the 'inverse problem' [K. Saraikin, C. Vafa, Non-supersymmetric black holes and topological strings, (hep-th/0703214)] and 'fake superpotentials' [A. Ceresole, G. Dall'Agata, Flow equations for non-BPS extremal black holes, JHEP 0703 (2007) 110, (hep-th/0702088)] for extremal (non-)supersymmetric black holes in type II compactifications. We use (orientifold of) a 'Swiss cheese' Calabi-Yau [J.P. Conlon, F. Quevedo, K. Suruliz, Large-volume flux compactifications: Moduli spectrum and D3/D7 soft supersymmetry breaking, JHEP 0508 (2005) 007, (hep-th/0505076)] expressed as a degree-18 hypersurface in WCP{sup 4}[1,1,1,6,9] in the 'large-volume-scenario' limit [V. Balasubramanian, P. Berglund, J.P. Conlon, F. Quevedo, Systematics of moduli stabilisation in Calabi-Yau flux compactifications, JHEP 0503 (2005) 007, (hep-th/0502058)]. The main result of our paper is that we show that by including non-perturbative {alpha}{sup '} and instanton corrections in the Kaehler potential and superpotential [T.W. Grimm, Non-perturbative corrections and modularity in N=1 type IIB compactifications, (arXiv: 0705.3253 [hep-th])], it may be possible to obtain a large-volume non-supersymmetric dS minimum without the addition of anti-D3 branes a la KKLT. The chosen Calabi-Yau has been of relevance also from the point of other studies of Kaehler moduli stabilization via non-perturbative instanton contributions [F. Denef, M.R. Douglas, B. Florea, Building a better racetrack, JHEP 0406 (2004) 034, (hep-th/0404257)] and non-supersymmetric AdS vacua (and their

  12. Accelerators/decelerators of achieving universal access to sexual and reproductive health services: a case study of Iranian health system

    Science.gov (United States)

    2013-01-01

    Background At the 1994 International Conference on Population and Development (ICPD), held in Cairo, the global community agreed to the goal of achieving universal access to sexual and reproductive health (SRH) and rights by 2015. This research explores the accelerators and decelerators of achieving universal access to the sexual and reproductive health targets and accordingly makes some suggestions. Method We have critically reviewed the latest national reports and extracted the background data on each SRH indicator. The key stakeholders, both national and international, were visited and interviewed at two sites. A total of 55 in-depth interviews were conducted with religious leaders, policy-makers, senior managers, senior academics, and health care managers. Six focus-group discussions were also held among health care providers. The study was qualitative in nature. Results Obstacles on the road to achieving universal access to SRH can be viewed from two perspectives. One gap exists between current achievements and the targets. The other gap arises due to age, marital status, and residency status. The most recently observed trends in the indicators of the universal access to SRH shows that the achievements in the “unmet need for family planning” have been poor. Unmet need for family planning could directly be translated to unwanted pregnancies and unwanted childbirths; the former calls for sexual education to underserved people, including adolescents; and the latter calls for access to safe abortion. Local religious leaders have not actively attended international goal-setting programs. Therefore, they usually do not presume a positive attitude towards these goals. Such negative attitudes seem to be the most important factors hindering the progress towards universal access to SRH. Lack of international donors to fund for SRH programs is also another barrier. In national levels both state and the society are interactively playing their roles. We have used a

  13. Evaluation of a pulsed glow discharge time-of-flight mass spectrometer as a detector for gas chromatography and the influence of the glow discharge source parameters on the information volume in chemical speciation analysis.

    Science.gov (United States)

    Fliegel, Daniel; Fuhrer, Katrin; Gonin, Marc; Günther, Detlef

    2006-09-01

    The figures of merit of a pulsed glow discharge time-of-flight mass spectrometer (GD-TOFMS) as a detector for gas chromatography (GC) analysis were evaluated. The mass resolution for the GD-TOFMS was determined on FWHM in the high mass range (208Pb+) as high as 5,500. Precision of 400 subsequent analyses was calculated on 63Cu+ to be better than 1% RSD with no significant drift over the time of the analysis. Isotope precision based on the 63Cu+/65Cu+ ratio over 400 analyses was 1.5% RSD. The limits of detection for gaseous analytes (toluene in methanol as solvent) were determined to be as low as several hundred ppb or several hundred pg absolute without using any pre-concentration technique. Furthermore, the different GD source parameters like capillary distance, cathode-anode spacing, and GD source pressure with regards to the accessible elemental, structural, and molecular information were evaluated. It was demonstrated that each of these parameters has severe influence on the ratio of elemental, structural, and parent molecular information in chemical speciation analysis.

  14. Effects of pressure-controlled and volume-controlled ventilation on respiratory mechanics and systemic stress response during laparoscopic cholecystectomy.

    Science.gov (United States)

    Sen, Oznur; Umutoglu, Tarik; Aydın, Nurdan; Toptas, Mehmet; Tutuncu, Ayse Cigdem; Bakan, Mefkur

    2016-01-01

    Pressure-controlled ventilation (PCV) is less frequently employed in general anesthesia. With its high and decelerating inspiratory flow, PCV has faster tidal volume delivery and different gas distribution. The same tidal volume setting, delivered by PCV versus volume-controlled ventilation (VCV), will result in a lower peak airway pressure and reduced risk of barotrauma. We hypothesized that PCV instead of VCV during laparoscopic surgery could achieve lower airway pressures and reduce the systemic stress response. Forty ASA I-II patients were randomly selected to receive either the PCV (Group PC, n = 20) or VCV (Group VC, n = 20) during laparoscopic cholecystectomy. Blood sampling was made for baseline arterial blood gases (ABG), cortisol, insulin, and glucose levels. General anesthesia with sevoflurane and fentanyl was employed to all patients. After anesthesia induction and endotracheal intubation, patients in Group PC were given pressure support to form 8 mL/kg tidal volume and patients in Group VC was maintained at 8 mL/kg tidal volume calculated using predicted body weight. All patients were maintained with 5 cmH2O positive-end expiratory pressure (PEEP). Respiratory parameters were recorded before and 30 min after pneumoperitonium. Assessment of ABG and sampling for cortisol, insulin and glucose levels were repeated 30 min after pneumoperitonium and 60 min after extubation. The P-peak levels observed before (18.9 ± 3.8 versus 15 ± 2.2 cmH2O) and during (23.3 ± 3.8 versus 20.1 ± 2.9 cmH2O) pneumoperitoneum in Group VC were significantly higher. Postoperative partial arterial oxygen pressure (PaO2) values are higher (98 ± 12 versus 86 ± 11 mmHg) in Group PC. Arterial carbon dioxide pressure (PaCO2) values (41.8 ± 5.4 versus 36.7 ± 3.5 mmHg) during pneumoperitonium and post-operative mean cortisol and insulin levels were higher in Group VC. When compared to VCV mode, PCV mode may improve compliance during pneumoperitoneum

  15. Renormalized Volume

    CERN Document Server

    Gover, A Rod

    2016-01-01

    For any conformally compact manifold with hypersurface boundary we define a canonical renormalized volume functional and compute an explicit, holographic formula for the corresponding anomaly. For the special case of asymptotically Einstein manifolds, our method recovers the known results. The anomaly does not depend on any particular choice of regulator, but the coefficients of divergences do. We give explicit formulae for these divergences valid for any choice of regulating hypersurface; these should be relevant to recent studies of quantum corrections to entanglement entropies. The anomaly is expressed as a conformally invariant integral of a local Q-curvature that generalizes the Branson Q-curvature by including data of the embedding. In each dimension this canonically defines a higher dimensional generalization of the Willmore energy/rigid string action. We show that the variation of these energy functionals is exactly the obstruction to solving a singular Yamabe type problem with boundary data along the...

  16. Thermodynamic volume of cosmological solitons

    Science.gov (United States)

    Mbarek, Saoussen; Mann, Robert B.

    2017-02-01

    We present explicit expressions of the thermodynamic volume inside and outside the cosmological horizon of Eguchi-Hanson solitons in general odd dimensions. These quantities are calculable and well-defined regardless of whether or not the regularity condition for the soliton is imposed. For the inner case, we show that the reverse isoperimetric inequality is not satisfied for general values of the soliton parameter a, though a narrow range exists for which the inequality does hold. For the outer case, we find that the mass Mout satisfies the maximal mass conjecture and the volume is positive. We also show that, by requiring Mout to yield the mass of dS spacetime when the soliton parameter vanishes, the associated cosmological volume is always positive.

  17. Thermodynamic Volume of Cosmological Solitons

    CERN Document Server

    Mbarek, Saoussen

    2016-01-01

    We present explicit expressions of the thermodynamic volume inside and outside the cosmological horizon of Eguchi-Hanson solitons in general odd dimensions. These quantities are calculable and well-defined regardless of whether or not the regularity condition for the soliton is imposed. For the inner case, we show that the reverse isoperimetric inequality is not satisfied for general values of the soliton parameter $a$, though a narrow range exists for which the inequality does hold. For the outer case, we find that the mass $M_{out}$ satisfies the maximal mass conjecture and the volume is positive. We also show that, by requiring $M_{out}$ to yield the mass of dS spacetime when the soliton parameter vanishes, the associated cosmological volume is always positive.

  18. Analysis of the structural parameters that influence gas production from the Devonian shale. Annual progress report, 1979-1980. Volume III. Data repository and reports published during fiscal year 1979-1980: production, unsponsored research

    Energy Technology Data Exchange (ETDEWEB)

    Negus-De Wys, J.; Dixon, J. M.; Evans, M. A.; Lee, K. D.; Ruotsala, J. E.; Wilson, T. H.; Williams, R. T.

    1980-10-01

    This document consists of the following papers: inorganic geochemistry studies of the Eastern Kentucky Gas Field; lithology studies of upper Devonian well cuttings in the Eastern Kentucky Gas Field; possible effects of plate tectonics on the Appalachian Devonian black shale production in eastern Kentucky; preliminary depositional model for upper Devonian Huron age organic black shale in the Eastern Kentucky Gas Field; the anatomy of a large Devonian black shale gas field; the Cottageville (Mount Alto) Gas Field, Jackson County, West Virginia: a case study of Devonian shale gas production; the Eastern Kentucky Gas Field: a geological study of the relationships of Ohio Shale gas occurrences to structure, stratigraphy, lithology, and inorganic geochemical parameters; and a statistical analysis of geochemical data for the Eastern Kentucky Gas Field.

  19. Soil thermal resistivity and thermal stability measuring instrument. Volume 2: Manual for operation and use of the thermal property analyzer and statistical weather analysis program to determine thermal design parameters

    Science.gov (United States)

    Boggs, S. A.; Radhakrishna, H. S.; Chu, F. Y.; Ford, G. L.; Griffin, J. D. A.; Steinmanis, J.

    1981-11-01

    Numerous considerations influence the thermal design of an underground power cable, including the soil thermal resistivity, thermal diffusivity and thermal stability. Each of these properties is a function of soil moisture which is in turn a function of past weather, soil composition, and biological burden. The Neher-McGrath formalism has been widely used for thermal cable design. However, this formalism assumes knowledge of soil thermal properties (resistivity and diffusivity). For design purposes, these parameters should be treated statistically, since weather varies greatly from year to year. As well, soil thermal property surveys are normally required along the route to assess the thermal quality of the native soil. This project is intended to fill the gap between the need to carry out thermal design and the use of the Neher-McGrath formalism which is normally employed. This goal has been addressed through: development of instrumentation and methods of measuring soil thermal properties in situ and in the laboratory; recommendation of methods for conducting soil surveys along a proposed cable route and of assessing the thermal quality of soils; and development of a computerized method to treat soil thermal design parameters on a statistical basis using computerized weather records as supplied by the US Environmental Data Service. The use of the methods and instrumentation developed as a result of this contract should permit less conservative thermal design thereby improving the economics of underground transmission. As well, these techniques and instrumentation facilitate weather-dependent prediction of cable ampacity for installed cables, monitoring of backfill thermal stability, and many other new practices.

  20. Volume-effect in radiation therapy part one: volume-effect and tumour; L'effet volume en radiotherapie premiere partie: effet volume et tumeur

    Energy Technology Data Exchange (ETDEWEB)

    Huchet, A.; Wu, J. [Hopital Europeen Georges-Pompidou (AP-HP), Service de Radiotherapie, 75 - Paris (France); Caudry, M.; Trouette, R.; Vendrely, V.; Causse, N.; Recaldini, L.; Dahan, O.; Maire, J.P. [Hopital Saint-Andre, Service de Radiotherapie, 33 - Bordeaux (France); Belkacemi, Y. [Centre de Lutte Contre le Cancer Oscar-Lambret, Dept. de Radiotherapie, 59 - Lille (France)

    2003-04-01

    Volume is an important parameter of radiation therapy. Local control is inversely related to tumor size and the complication rate increases with the importance of the irradiated volume. Although the effect of irradiated volume has been widely reported since the beginning of radiotherapy, it has been less studied than other radiation parameters such as dose, fractionation, or treatment duration. One of the first organ system in which the adverse effect of increased volume was well defined is the skin. Over the last twenty years, numerous mathematical models have been developed for different organs. In this report we will discuss the relation between irradiated volume and tumor control. In a second article we will study the impact of irradiated volume on radiation adverse effects. (authors)

  1. Suppression of the chain nuclear fusion reaction based on the p+{sup 11}B reaction because of the deceleration of alpha particles

    Energy Technology Data Exchange (ETDEWEB)

    Shmatov, M. L., E-mail: M.Shmatov@mail.ioffe.ru [Ioffe Institute (Russian Federation)

    2016-09-15

    It is shown that a rapid deceleration of alpha particles in matter of electron temperature up to 100 keV leads a strong suppression of the chain nuclear fusion reaction on the basis of the p+{sup 11}B reaction with the reproduction of fast protons in the α+{sup 11}B and n+{sup 10}B reactions. The statement that the chain nuclear fusion reaction based on the p+{sup 11}B reaction with an acceleration of {sup 11}B nuclei because of elastic alpha-particle scattering manifests itself in experiments at the PALS (Prague Asterix Laser System) facility is analyzed.

  2. Reevaluation of the AAPM TG-43 brachytherapy dosimetry parameters for an 125I seed, and the influence of eye plaque design on dose distributions and dose-volume histograms

    Science.gov (United States)

    Aryal, Prakash

    The TG-43 dosimetry parameters of the Advantage(TM) 125I model IAI-125A brachytherapy seed were studied. An investigation using modern MCNP radiation transport code with updated cross-section libraries was performed. Twelve different simulation conditions were studied for a single seed by varying the coating thickness, mass density, photon energy spectrum and cross-section library. The dose rate was found to be 6.3% lower at 1 cm in comparison to published results. New TG-43 dosimetry parameters are proposed. The dose distribution for a brachytherapy eye plaque, model EP917, was investigated, including the effects of collimation from high-Z slots. Dose distributions for 26 slot designs were determined using Monte Carlo methods and compared between the published literature, a clinical treatment planning system, and physical measurements. The dosimetric effect of the composition and mass density of the gold backing was shown to be less than 3%. Slot depth, width, and length changed the central axis (CAX) dose distributions by < 1% per 0.1 mm in design variation. Seed shifts in the slot towards the eye and shifts of the 125I-laden silver rod within the seed had the greatest impact on the CAX dose distribution, changing it by 14%, 9%, 4.3%, and 2.7% at 1, 2, 5, and 10 mm, respectively, from the inner scleral surface. The measured, full plaque slot geometry delivered 2.4% +/- 1.1% higher dose along the plaque's CAX than the geometry provided by the manufacturer and 2.2%+/-2.3% higher than Plaque Simulator(TM) (PS) treatment planning software (version 5.7.6). The D10 for the simulated tumor, inner sclera, and outer sclera for the measured slot plaque to manufacturer provided slot design was 9%, 10%, and 19% higher, respectively. In comparison to the measured plaque design, a theoretical plaque having narrow and deep slots delivered 30%, 37%, and 62% lower D 10 doses to the tumor, inner sclera, and outer sclera, respectively. CAX doses at --1, 0, 1, and 2 mm were also

  3. Correlations between the volume of dominant periphytic algae species and the water quality parameters in Gufu River%古夫河着生藻类优势种体积与水质因子的相关性研究

    Institute of Scientific and Technical Information of China (English)

    刘奕伶; 葛继稳; 李艳元; 彭凤姣; 甘娟; 谷金普

    2015-01-01

    通过研究长江三峡库区古夫河着生藻类优势种体积的变化,探索影响其体积的主要水质因子,为河流水质评价提供依据.于2010年12月至2012年2月,对古夫河着生藻类和地表水采样11次,共鉴定着生藻类197种,检测水质指标10项.选取Mcnaughton优势度指数(Y)>0.02的着生藻类(共30种)作为优势种并计算体积;利用主成分分析(PCA)分析优势种藻类在不同月份的体积变化.结果显示,硅藻门对冷暖季的变化较为敏感.将水质因子与优势种藻类体积进行典范对应分析(CCA),结果显示水质因子与藻类体积相关性大小为:溶解氧>氨氮>叶绿素 a>酸碱度>硝态氮>总磷>水温>总氮>总有机碳>化学需氧量.Monte Carlo显著性检验结果为溶解氧和氨氮对着生藻类体积的影响最大,其次为叶绿素a、酸碱度和硝态氮.硅藻门藻类体积的变化可以判断古夫河水体中溶解氧、氨氮、叶绿素a、酸碱度、硝态氮的含量与变化.%Changes in volume of periphytic algae dominant species in Gufu River of Three Gorges Reservoir Area were studied and the main parameters of water quality influencing the change were explored, in order to provide an evidence for the quality assessment of river water. Periphytic algae and water quality samples were collected eleven times from December 2010 to February, 2012. A total of 197 species were identified from the periphytic algae samples, and ten water quality factors were measured. The species of which Mcnaughton dominance-index (Y) was large than 0.02 were chosen as the dominant species and their volumes were calculated. The analysis of the volume changes of these dominant species (thirty species) during various months by using the Principal Component Analysis (PCA) showed that Bacillariophyta were more sensitive to the seasonal variations. The analysis of the relationship between the water quality parameters and the volume of dominant species by

  4. Infrared Drying Parameter Optimization

    Science.gov (United States)

    Jackson, Matthew R.

    In recent years, much research has been done to explore direct printing methods, such as screen and inkjet printing, as alternatives to the traditional lithographic process. The primary motivation is reduction of the material costs associated with producing common electronic devices. Much of this research has focused on developing inkjet or screen paste formulations that can be printed on a variety of substrates, and which have similar conductivity performance to the materials currently used in the manufacturing of circuit boards and other electronic devices. Very little research has been done to develop a process that would use direct printing methods to manufacture electronic devices in high volumes. This study focuses on developing and optimizing a drying process for conductive copper ink in a high volume manufacturing setting. Using an infrared (IR) dryer, it was determined that conductive copper prints could be dried in seconds or minutes as opposed to tens of minutes or hours that it would take with other drying devices, such as a vacuum oven. In addition, this study also identifies significant parameters that can affect the conductivity of IR dried prints. Using designed experiments and statistical analysis; the dryer parameters were optimized to produce the best conductivity performance for a specific ink formulation and substrate combination. It was determined that for an ethylene glycol, butanol, 1-methoxy 2- propanol ink formulation printed on Kapton, the optimal drying parameters consisted of a dryer height of 4 inches, a temperature setting between 190 - 200°C, and a dry time of 50-65 seconds depending on the printed film thickness as determined by the number of print passes. It is important to note that these parameters are optimized specifically for the ink formulation and substrate used in this study. There is still much research that needs to be done into optimizing the IR dryer for different ink substrate combinations, as well as developing a

  5. Non-Linear Logging Parameters Inversion

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The non-linear logging parameters inversion is based on the field theory, information optimization and predication theory. It uses seismic charaoters,geological model and logging data as a restriction to inverse 2D, 3D logging parameters data volume. Using this method,

  6. Neutron Resonance Parameters for Ra-226 (Radium)

    Science.gov (United States)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Volume 24 `Neutron Resonance Parameters' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms'. It provides the neutron resonance parameters for the isotope Ra-226 (Radium).

  7. Deceleration of Alpha Particles in the Solar Wind by Instabilities and the Rotational Force: Implications for Heating, Azimuthal Flow, and the Parker Spiral Magnetic Field

    CERN Document Server

    Verscharen, Daniel; Bourouaine, Sofiane; Hollweg, Joseph V

    2014-01-01

    Protons and alpha particles in the fast solar wind are only weakly collisional and exhibit a number of non-equilibrium features, including relative drifts between particle species. Two non-collisional mechanisms have been proposed for limiting differential flow between alpha particles and protons: plasma instabilities and the rotational force. Both mechanisms decelerate the alpha particles. In this paper, we derive an analytic expression for the rate $Q_{\\mathrm{flow}}$ at which energy is released by alpha-particle deceleration, accounting for azimuthal flow and conservation of total momentum. We find that $Q_{\\mathrm{flow}} > 0 $ at $r r_{\\mathrm{crit}}$. We compare the value of $Q_{\\mathrm{flow}}$ at $r< r_{\\mathrm{crit}}$ with empirical heating rates for protons and alpha particles, denoted $Q_{\\mathrm{p}}$ and $Q_{\\alpha}$, deduced from in-situ measurements of fast-wind streams from the Helios and Ulysses spacecraft. We find that $Q_{\\mathrm{flow}}$ exceeds $Q_{\\alpha}$ at $r < 1\\,\\mathrm{AU}$, $Q_{...

  8. The Gruneisen parameter for silver azide

    Science.gov (United States)

    Zhuravlyov, Yu. N.; Lisitsyn, V. M.

    2011-12-01

    A first-principle procedure is proposed to determine the Gruneisen parameter for a crystal by calculating the external pressure and the vibration spectrum as functions of the volume of a unit cell. In the gradient approximation of the electron density functional theory, on the basis of a linear combination of atomic orbitals, the elastic and the thermodynamic Gruneisen parameters of silver azide, which decrease with volume (with increasing pressure), are calculated with the use of the CRYSTAL09 code. The equilibrium values of the parameter γ0 for various cold equations of state of crystals and for the thermodynamic models used are, respectively, ~2.3 and 1.6.

  9. Prewarning of deceleration capacity of rate for acute myocardial infarction%心率减速力对急性心肌梗死的预警研究

    Institute of Scientific and Technical Information of China (English)

    黄佐贵; 杜国伟; 殷波

    2011-01-01

    目的:探讨心率减速力对急性心肌梗死的预警价值.方法:应用24 h动态心电图记录120例急性心肌梗死患者(急性心肌梗死组)和120例非急性心肌梗死患者(非急性心肌梗死组)的心率减速力值和心率加速力值,并进行预警分析.结果:2组冠状动脉病变支数、心率减速力值及心率加速力值比较差异均有统计学意义(P<0.01).急性心肌梗死组1 a病死率:心率减速力值≥4.5 ms为1.66%,2.6~4.4 ms为7.50%,≤2.5 ms为10.00%,差异有统计学意义(P<0.01);非急性心肌梗死组心率减速力各值中均无死亡病例;心率加速力值≤-7.0 ms,除急性心肌梗死组1 a病死率为0.83%外.余均未死亡.结论:心率减速力值测定能定量、单独分析和测定迷走神经作用的强度,对急性心肌梗死猝死高危人群筛选与预警有较强的实用价值.%Objective To study the prewarning value of deceleration capacity of rate to acute myocardial infarction. Methods The deceleration capacity of rate and acceleration capacity of rate were recorded with 24-hour dynamic electrocardiogram in 120 patients with acute myocardial infarction and the 120 patients without acute myocardial infarction. Prewarning analysis was done. Results There were significant differences in coronary artery lesion branch numbers, deceleration capacity of rate and acceleration capacity of rate between two groups(P<0.01). The one-year fatality rate was 1.66%when deceleration capacity of rate value was larger than 4.5 ms, 7.50% between 2.6 and 4.4 ms, and 10.0% when smaller than 2. 5 ms, which showed significant differences(P<0. 01) in the patients with acute myocardial infarction. No death occurred in the patients without acute myocardial infarction. Acceleration capacity of rate value was smaller than -7.0 ms. The one-year fatality rate of the patients with acute myocardial infarction was 0.83%. Conclusion The deceleration capacity of rate value can be used to

  10. Study of some cosmological parameters for interacting new holographic dark energy model in f(T) gravity

    Science.gov (United States)

    Ranjit, Chayan; Rudra, Prabir

    2016-10-01

    The present work is based on the idea of an interacting framework of new holographic dark energy (HDE) with cold dark matter in the background of f(T) gravity. Here, we have considered the flat modified Friedmann universe for f(T) gravity which is filled with new HDE and dark matter. We have derived some cosmological parameters like deceleration parameter, equation of state (EoS) parameter, state-finder parameters, cosmographic parameters, Om parameter and graphically investigated the nature of these parameters for the above mentioned interacting scenario. The results are found to be consistent with the accelerating universe. Also, we have graphically investigated the trajectories in ω-ω‧ plane for different values of the interacting parameter and explored the freezing region and thawing region in ω-ω‧ plane. Finally, we have analyzed the stability of this model.

  11. Study of Some Cosmological Parameters for Interacting New Holographic Dark Energy Model in f(T) Gravity

    CERN Document Server

    Ranjit, Chayan

    2015-01-01

    The present work is based on the idea of an interacting framework of new holographic dark energy with cold dark matter in the background of $f(T)$ gravity. Here, we have considered the flat modified Friedmann universe for $f(T)$ gravity which is filled with new Holographic dark energy and dark matter. We have derived some cosmological parameters like Deceleration parameter, EoS parameter, State-finder parameters, Cosmographic parameters, {\\it Om} parameter and graphically investigated the nature of these parameters for the above mentioned interacting scenario. The results are found to be consistent with the accelerating universe. Also we have graphically investigated the trajectories in $\\omega $--$ \\omega'$ plane for different values of the interacting parameter and explored the freezing region and thawing region in $\\omega $--$ \\omega'$ plane. Finally, we have analyzed the stability of this model.

  12. Volume-effect and radiotherapy [2]. Part 2: volume-effect and normal tissue; Effet volume en radiotherapie [2]. Deuxieme partie: volume et tolerance des tissus sains

    Energy Technology Data Exchange (ETDEWEB)

    Huchet, A.; Caudry, M.; Trouette, R.; Vendrely, V.; Causse, N.; Recaldini, L.; Maire, J.P. [Hopital Saint Andre, Service de Radiotherapie, 33 - Bordeaux (France); Belkacemi, Y. [Centre de Lutte Contre le Cancer Oscar-Lambret, Dept. de Radiotherapie, 59 - Lille (France); Atlan, D. [Hopital Europeen Georges Pompidou, Service de Radiotherapie, 75 - Paris (France)

    2003-10-01

    The first part of our work has focused on the relationship bet men tumor Volume and tumor control. Indeed, it is well known that the importance of irradiated volume could be a main parameter of radiation-induced complications. Numerous mathematical models have described the correlation between the irradiated volume and the risk of adverse effects. These models should predict the complication rate of each treatment planning. At the present time late effects have been the most studied. In this report we firstly propose a review of different mathematical models described for volume effect. Secondly, we will discuss whether these theoretical considerations can influence our view of radiation treatment planning optimization. (authors)

  13. Observational constraints on EoS parameters of emergent universe

    Science.gov (United States)

    Paul, Bikash Chandra; Thakur, Prasenjit

    2017-04-01

    We investigate emergent universe model using recent observational data of the background as well as the growth tests. The flat emergent universe model obtained by Mukherjee et al. is permitted with a non-linear equation of state (in short, EoS) (p=Aρ -B ρ^{1/2}), where A and B are constants (here in our analysis A=0 is considered). We carried out analysis considering the Wang-Steinhardt ansatz for growth index (γ ) and growth function (f defined as f=Ωm^{γ } (a)). The best-fit values of the EoS and growth parameters are determined making use of chi-square minimization technique. Here we specifically determined the best-fit value and the range of value of the present matter density (Ω m) and Hubble parameter (H0). The best-fit values of the EoS parameters are used to study the evolution of the growth function f, growth index γ , state parameter ω and deceleration parameter (q) for different red shift parameter z. The late accelerating phase of the universe in the EU model is accommodated satisfactorily.

  14. Constraints on the exponential $f(R)$ model from latest Hubble parameter measurements

    CERN Document Server

    Chen, Yun; Lee, Chung-Chi; Luo, Ling-Wei; Zhu, Zong-Hong

    2014-01-01

    We investigate the viable exponential $f(R)$ gravity in the metric formalism with $f(R)=-\\beta R_s (1-e^{-R/R_s})$. The latest sample of the Hubble parameter measurements with 23 data points is used to place bounds on this $f(R)$ model. A joint analysis is also performed with the luminosity distances of Type Ia supernovae and baryon acoustic oscillations in the clustering of galaxies, and the shift parameters from the cosmic microwave background measurements, which leads to $0.2401.47$ at 1$\\sigma$ confidence level. The evolutions of the deceleration parameter $q(z)$ and the effective equations of state $\\omega_{de}^{eff}(z)$ and $\\omega_{tot}^{eff}(z)$ are displayed. By taking the best-fit parameters as prior values, we work out the transition redshift (deceleration/acceleration) $z_T$ to be about 0.77. It turns out that the recent observations are still unable to distinguish the background dynamics in the $\\Lambda$CDM and exponential $f(R)$ models.

  15. Critical Imperative for the Reform of British Interpretation of Fetal Heart Rate Decelerations: Analysis of FIGO and NICE Guidelines, Post-Truth Foundations, Cognitive Fallacies, Myths and Occam's Razor.

    Science.gov (United States)

    Sholapurkar, Shashikant L

    2017-04-01

    Cardiotocography (CTG) has disappointingly failed to show good predictability for fetal acidemia or neonatal outcomes in several large studies. A complete rethink of CTG interpretation will not be out of place. Fetal heart rate (FHR) decelerations are the most common deviations, benign as well as manifestation of impending fetal hypoxemia/acidemia, much more commonly than FHR baseline or variability. Their specific nomenclature is important (center-stage) because it provides the basic concepts and framework on which the complex "pattern recognition" of CTG interpretation by clinicians depends. Unfortunately, the discrimination of FHR decelerations seems to be muddled since the British obstetrics adopted the concept of vast majority of FHR decelerations being "variable" (cord-compression). With proliferation of confusing waveform criteria, "atypical variables" became the commonest cause of suspicious/pathological CTG. However, National Institute for Health and Care Excellence (NICE) (2014) had to disband the "typical" and "atypical" terminology because of flawed classifying criteria. This analytical review makes a strong case that there are major and fundamental framing and confirmation fallacies (not just biases) in interpretation of FHR decelerations by NICE (2014) and International Federation of Gynecology and Obstetrics (FIGO) (2015), probably the biggest in modern medicine. This "post-truth" approach is incompatible with scientific practice. Moreover, it amounts to setting oneself for failure. The inertia to change could be best described as "backfire effect". There is abundant evidence that head-compression (and other non-hypoxic mediators) causes rapid rather than shallow/gradual decelerations. Currently, the vast majority of decelerations are attributed to unproven cord compression underpinned by flawed disproven pathophysiological hypotheses. Their further discrimination based on abstract, random, trial and error criteria remains unresolved suggesting a

  16. Critical Imperative for the Reform of British Interpretation of Fetal Heart Rate Decelerations: Analysis of FIGO and NICE Guidelines, Post-Truth Foundations, Cognitive Fallacies, Myths and Occam’s Razor

    Science.gov (United States)

    Sholapurkar, Shashikant L.

    2017-01-01

    Cardiotocography (CTG) has disappointingly failed to show good predictability for fetal acidemia or neonatal outcomes in several large studies. A complete rethink of CTG interpretation will not be out of place. Fetal heart rate (FHR) decelerations are the most common deviations, benign as well as manifestation of impending fetal hypoxemia/acidemia, much more commonly than FHR baseline or variability. Their specific nomenclature is important (center-stage) because it provides the basic concepts and framework on which the complex “pattern recognition” of CTG interpretation by clinicians depends. Unfortunately, the discrimination of FHR decelerations seems to be muddled since the British obstetrics adopted the concept of vast majority of FHR decelerations being “variable” (cord-compression). With proliferation of confusing waveform criteria, “atypical variables” became the commonest cause of suspicious/pathological CTG. However, National Institute for Health and Care Excellence (NICE) (2014) had to disband the “typical” and “atypical” terminology because of flawed classifying criteria. This analytical review makes a strong case that there are major and fundamental framing and confirmation fallacies (not just biases) in interpretation of FHR decelerations by NICE (2014) and International Federation of Gynecology and Obstetrics (FIGO) (2015), probably the biggest in modern medicine. This “post-truth” approach is incompatible with scientific practice. Moreover, it amounts to setting oneself for failure. The inertia to change could be best described as “backfire effect”. There is abundant evidence that head-compression (and other non-hypoxic mediators) causes rapid rather than shallow/gradual decelerations. Currently, the vast majority of decelerations are attributed to unproven cord compression underpinned by flawed disproven pathophysiological hypotheses. Their further discrimination based on abstract, random, trial and error criteria remains

  17. Radiation dose-volume effects in the lung

    DEFF Research Database (Denmark)

    Marks, Lawrence B; Bentzen, Soren M; Deasy, Joseph O;

    2010-01-01

    The three-dimensional dose, volume, and outcome data for lung are reviewed in detail. The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold "tolerance dose-volume" levels. There are strong volume and fractionation effects....

  18. Mitral E wave deceleration time to peak E velocity ratio and cardiovascular outcome in hypertensive patients during antihypertensive treatment (from the LIFE echo-substudy)

    DEFF Research Database (Denmark)

    Chinali, Marcello; Aurigemma, Gerard P; de Simone, Giovanni;

    2009-01-01

    The early mitral flow deceleration time (DTE) is a prognostically validated marker of left ventricular diastolic dysfunction. It has been reported that the DTE is influenced by the loading conditions, which can vary during antihypertensive treatment. We hypothesized that normalization of the DTE....... We examined the utility of the MDI at baseline and as a time-varying predictor of incident CV events. Of the 770 patients, 70 (9%) had CV events. The baseline MDI was positively associated with age and relative wall thickness and negatively associated with gender and heart rate (all p ....01). Unadjusted Cox regression analysis showed a positive association between the baseline MDI and CV events (hazard ratio 1.21, 95% confidence interval 1.07 to 1.37, p = 0.002). In the time-varied Cox models, a greater in-treatment MDI was associated with a greater rate of CV events (hazard ratio 1.43, 95...

  19. Parameters, Volume 23, Number 4, Winter 1993-94

    Science.gov (United States)

    1993-01-01

    School fencing medal. I resolved on personal combat ti larme blanche . The savage saw me coming. I was not more than twenty yards away. He... awaited me...disconcerting to see a US Special Forces sergeant, in camouflage fatigues with bloused trousers and a snappy beret, pop in and out of the Defense Ministry in the

  20. Parameters: US Army War College Quarterly. Volume 20. Number 4

    Science.gov (United States)

    1990-12-01

    South Vietnam; and siege-breaking at Dien Bien Phu and Khe Sanh. In all of these cases, CAS substituted for a lack of available artillery assets, and...service persona . But is it in the Army’s interest to take over CAS, much less all of tactical aviation? No. The Army cannot afford the force structure...of a Former Iron Curtain Official." 10 (September, 1980), 8-15. Radvanyi, Janos. "Dien Bien Phu: Tiirt ’ears After." 15 (Summer, 1985), 63-68. Raho

  1. Principle analysis of deceleration of the high-rise escape apparatus%高楼逃生装置的减速原理分析

    Institute of Scientific and Technical Information of China (English)

    乔印虎; 苏国用; 杨杰; 龚建; 王冲

    2015-01-01

    High-rise escape apparatus is designed to help more personnel escape safely from the scene in shortest time. However, how to ensure the escaping individual decrease potential energy and kinetic energy steady and fast is the key to the design. This design uses the principle of negative feedback close-loop system to achieve pure mechanical design, uses the escape personel self weight to realize self-dece Leration. Analyze the deceleration principle to understand its structural design and working mechanism. Making finite element analysis to the important deceleration parts through solidworks Simulations oftware to detect the weakest part is beneficial to product design and production.%高楼逃生装置的设计原则是利用最短的时间,使更多的人安全地离开事发现场。此类设计所要解决的关键性难题是如何将逃生者的势能与动能平稳快速地降下来。采用负反馈闭环系统原理实现纯机械化设计,利用逃生人员自重实现自减速功能。对该装置进行减速原理进行分析,以便理解其整体结构设计与工作机理。通过Solidworks>Simulation软件对减速结构重要零件进行有限元分析,找出该减速装置最容易失效的部位,有利于产品的设计与生产。

  2. 减速制动时机械式自动变速器车辆换档控制策略%Shifting Control Strategy of Deceleration Braking for Automated Mechanical Transmission Vehicle

    Institute of Scientific and Technical Information of China (English)

    朱敏; 刘海鸥; 王尔烈; 陈慧岩

    2015-01-01

    将制动工况分为普通制动、紧急制动和惯性制动三种,研究不同制动工况下手动变速器(Manual transmission, MT)车辆优秀驾驶员的操控特点。将普通制动工况和紧急制动工况归为减速制动这一类情况对机械式自动变速器(Automated mechanical transmission, AMT)车辆进行研究。结合某重型越野车辆的车辆参数和试验数据,分析位置式电控柴油机的特性,提出油门关闭时其发动机转速存在一个固有转速下降率的概念,指出由于外界的原因来延缓或加快这一变化率时,发动机都将产生阻碍这一运动趋势的转矩。在对制动过程中传动系统动力学模型进行详细分析的基础上,讨论不同制动工况下发动机的作用。根据发动机转速及其下降率、变速器输出轴转速及其下降率,结合当前档位、离合器状态以及制动信号来识别普通制动和紧急制动,制定减速制动时AMT车辆换档控制策略,通过实车道路试验进行验证。%Braking conditions are divided into three categories: ordinary braking, emergency braking and inertia braking, then a research about the characteristics of manual transmission(MT) vehicle excellent drivers’ manipulation in different braking conditions is made. The conditions of ordinary braking and emergency braking are classified as deceleration braking, and then begin the study of the automated mechanical transmission(AMT) vehicle. Combined with a heavy off-road vehicle’s parameters and test data, a detailed analysis of the characteristics of Position-type electronically controlled diesel engine is carried out. Then the concept of the natural descending rate of engine speed when throttle is closed is put forward, to slow down or speed up the rate due to external reasons, the engine will produce torque to hinder this movement trends. On the basis of a detailed analysis of the drive system dynamics model of the braking process, the role

  3. An adjoint data assimilation method for optimizing frictional parameters on the afterslip area

    Science.gov (United States)

    Kano, Masayuki; Miyazaki, Shin'ichi; Ito, Kosuke; Hirahara, Kazuro

    2013-12-01

    Afterslip sometimes triggers subsequent earthquakes within a timescale of days to several years. Thus, it may be possible to predict the occurrence of such a triggered earthquake by simulating the spatio-temporal evolution of afterslip with estimated frictional parameters. To demonstrate the feasibility of this idea, we consider a plate interface model where afterslip propagates between two asperities following a rate-and-state friction law, and we adopt an adjoint data assimilation method to optimize frictional parameters. Synthetic observation data are sampled as the slip velocities on the plate interface during 20 days. It is found that: (1) all frictional parameters are optimized if the data sets consists not only of the early phase of afterslip or acceleration, but also of the decaying phase or deceleration; and (2) the prediction of the timing of the triggered earthquake is improved by using adjusted frictional parameters.

  4. Evaluation of deceleration capacity rate for short-term prognosis in patients with chronic heart failure%心率减速力对慢性心力衰竭患者近期预后的评估价值

    Institute of Scientific and Technical Information of China (English)

    张萍; 娄美娜; 章慧娣

    2015-01-01

    Objective To assess the deceleration capacity (DC) rate for the severity and short-term prognosis in patients with chronic heart failure (CHF). Methods Eighty CHF patients in the First Affiliated Hospital of Wenzhou Medical University from October 2012 to May 2013 were enrolled as the CHF group, and the same period of age, gender matched seventy-six healthy cases served as the control group. The levels of DC and average heart rate parameter were detected by dynamic electrocardiogram, and the left ventricular end-diastolic diameter (LVEDd) and left ventricular ejection fraction (LVEF) were measured by echocardiography. According to the NewYork Heart Association classification, CHF patients were divided into the classⅡgroup (26 cases), classⅢgroup (28 cases) and classⅣgroup (26 cases), and DC LVEDd and LVEF were compared between the CHF subgroups. The levels of DC and average heart rate parameter were compared between the CHF group and control group. Pearsonˊs method was employed to analyze the DC, LVEDd and LVEF. CHF patients were followed up for 6-12 months. The cardiac death, malignant ventricular arrhythmia, cardiac shock and re-hospitalization due to heart failure were further analyzed according to the different DC values in the CHF patients (low, intermediate and high risk groups). Results Compared with the control group, DC value decreased and average heart rate increased in the CHF group (t=2.28, 2.24; all P 0.05). The incidence of cardiac death, malignant ventricular arrhythmia and re-hospitalization due to heart failure in the high-risk group were higher than those in the low and intermediate risk groups (χ2=5.08, 7.65, 6.08; all P0.05)。随访结果发现,高危组患者心源性猝死,恶性室性心律失常及反复心力衰竭发作再住院的发生率明显高于低中危组(χ2=5.08、7.65、6.08,P均<0.05)。结论CHF患者血清DC值明显降低,且随着心功能的恶化而下降,DC值不仅能反映心力衰竭的严

  5. A new type of exact arbitrarily inhomogeneous cosmology: evolution of deceleration in the flat homogeneous-on-average case

    Science.gov (United States)

    Hellaby, Charles

    2012-01-01

    A new method for constructing exact inhomogeneous universes is presented, that allows variation in 3 dimensions. The resulting spacetime may be statistically uniform on average, or have random, non-repeating variation. The construction utilises the Darmois junction conditions to join many different component spacetime regions. In the initial simple example given, the component parts are spatially flat and uniform, but much more general combinations should be possible. Further inhomogeneity may be added via swiss cheese vacuoles and inhomogeneous metrics. This model is used to explore the proposal, that observers are located in bound, non-expanding regions, while the universe is actually in the process of becoming void dominated, and thus its average expansion rate is increasing. The model confirms qualitatively that the faster expanding components come to dominate the average, and that inhomogeneity results in average parameters which evolve differently from those of any one component, but more realistic modelling of the effect will need this construction to be generalised.

  6. A New Type of Exact Arbitrarily Inhomogeneous Cosmology: Evolution of Deceleration in the Flat Homogeneous-On-Average Case

    CERN Document Server

    Hellaby, Charles

    2012-01-01

    A new method for constructing exact inhomogeneous universes is presented, that allows variation in 3 dimensions. The resulting spacetime may be statistically uniform on average, or have random, non-repeating variation. The construction utilises the Darmois junction conditions to join many different component spacetime regions. In the initial simple example given, the component parts are spatially flat and uniform, but much more general combinations should be possible. Further inhomogeneity may be added via swiss cheese vacuoles and inhomogeneous metrics. This model is used to explore the proposal, that observers are located in bound, non-expanding regions, while the universe is actually in the process of becoming void dominated, and thus its average expansion rate is increasing. The model confirms qualitatively that the faster expanding components come to dominate the average, and that inhomogeneity results in average parameters which evolve differently from those of any one component, but more realistic mode...

  7. K-shell to K-shell charge transfer in collisions of bare decelerated S ions with Ar

    Energy Technology Data Exchange (ETDEWEB)

    Schulz, M.; Justiniano, E.; Konrad, J.; Schuch, R.; Salin, A.

    1987-05-14

    The impact parameter dependence of the single and double K-shell to K-shell charge transfer probabilities was studied by measuring triple coincidences between two K x-rays and the scattered projectiles for 16 MeV S W -Ar. It was found that the data are internally consistent with independent electron assumptions, but cannot be reproduced by different calculations of single electron transfer probabilities applying the independent electron model. Also a calculation of double K-vacancy transfer including electron correlations which described the HeS -He charge transfer probabilities well, is not in good agreement with the present data. The data allow a more sensitive test of various calculations on K to K charge transfer than recent experimental studies on collision systems with hydrogen-like projectiles.

  8. Ovarian volume throughout life

    DEFF Research Database (Denmark)

    Kelsey, Thomas W; Dodwell, Sarah K; Wilkinson, A Graham

    2013-01-01

    cancer. To date there is no normative model of ovarian volume throughout life. By searching the published literature for ovarian volume in healthy females, and using our own data from multiple sources (combined n=59,994) we have generated and robustly validated the first model of ovarian volume from...... to about 2.8 mL (95% CI 2.7-2.9 mL) at the menopause and smaller volumes thereafter. Our model allows us to generate normal values and ranges for ovarian volume throughout life. This is the first validated normative model of ovarian volume from conception to old age; it will be of use in the diagnosis...

  9. Reduction of Volume-preserving Flows on an n-dimensional Manifold

    Institute of Scientific and Technical Information of China (English)

    Yong-ai Zheng; De-bin Huang; Zeng-rong Liu

    2003-01-01

    A geometric reduction procedure for volume-preserving flows with a volume-preserving symmetry on an n-dimensional manifold is obtained. Instead of the coordinate-dependent theory and the concrete coordinate transformation, we show that a volume-preserving flow with a one-parameter volume-preserving symmetry on an n-dimensional manifold can be reduced to a volume-preserving flow on the corresponding (n - 1)-dimensional quotient space. More generally, if it admits an r-parameter volume-preserving commutable symmetry, then the reduced flow preserves the corresponding (n - r)-dimensional volume form.

  10. Lumped-parameter models

    Energy Technology Data Exchange (ETDEWEB)

    Ibsen, Lars Bo; Liingaard, M.

    2006-12-15

    A lumped-parameter model represents the frequency dependent soil-structure interaction of a massless foundation placed on or embedded into an unbounded soil domain. In this technical report the steps of establishing a lumped-parameter model are presented. Following sections are included in this report: Static and dynamic formulation, Simple lumped-parameter models and Advanced lumped-parameter models. (au)

  11. Imaging characteristics of a volume holographic lens

    Science.gov (United States)

    Yang, Jing; Jiang, Zhu-qing; Xu, Zhi-qiang; Liu, Shao-jie; Sun, Ya-jun; Tao, Shi-quan

    2009-07-01

    A volume holographic grating lens can reconstruct the three-dimensional information by conducting multiple optical slicing of an object based on Bragg selectivity of the volume holographic grating. In this paper, we employ the point-spread function of volume holographic imaging system to theoretically analyze its imaging resolution. In the experiments, the volume holographic gratings are made with a spherical reference (SR) and a planar reference (PR), respectively, and used as volume holographic imaging lens in our imaging system. The longitudinal and lateral defocusing characteristics of volume holographic lens with SR and with PR are investigated experimentally by displacing the interested objects from original reference location, respectively. The effects of the parameters of the volume holographic lens on the longitudinal and lateral resolution are also discussed. The experimental results show that increasing the size of the volume holographic lens can improve the depth resolution, and in particular, it has greater influence on SR VHI. The lateral selectivity of SR VHI is more sensitive than that of PR VHI, and the Bragg degenerate diffraction of PR VHI on the y axis is obviously observed.

  12. Neonatal taurine and alanine modulate anxiety-like behavior and decelerate cortical spreading depression in rats previously suckled under different litter sizes.

    Science.gov (United States)

    Francisco, Elian da Silva; Guedes, Rubem Carlos Araújo

    2015-11-01

    The amino acids taurine and alanine play a role in several physiological processes, including behavior and the electrical activity of the brain. In this study, we investigated the effect of treatment with taurine or alanine on anxiety-like behavior and the excitability-dependent phenomenon known as cortical spreading depression (CSD), using rats suckled in litters with 9 and 15 pups (groups L9 and L15). From postnatal days 7 to 27, the animals received per gavage 300 mg/kg/day of taurine or alanine or both. At 28 days, we tested the animals in the elevated plus maze, and at 33-35 days, we recorded CSD and analyzed its velocity of propagation, amplitude, and duration. Compared with water-treated controls, the L9 groups treated with taurine or alanine displayed anxiolytic behavior (higher number of entries in the open arms; p taurine, alanine, or both) treated at adulthood (90-110 days). The L15 condition resulted in smaller durations and higher CSD velocities compared with the L9 condition. Besides reinforcing previous evidence of behavioral modulation by taurine and alanine, our data are the first confirmation that treatment with these amino acids decelerates CSD regardless of lactation conditions (normal versus unfavorable lactation) or age at amino acid administration (young versus adult). The results suggest a modulating role for both amino acids on anxiety behavior and neuronal electrical activity.

  13. Utility of pulmonary venous flow diastolic deceleration time in an adult patient undergoing surgical closure of atrial septal defect and coronary artery bypass grafting

    Directory of Open Access Journals (Sweden)

    Dharmesh R Agrawal

    2013-01-01

    Full Text Available Acute left ventricular (LV failure has been reported after surgical closure of atrial septal defect (ASD in adult patients. We report acute LV failure in a 56 year old gentleman following coronary artery bypass grafting (CABG and surgical closure of ASD. Transesophageal echocardiography examination of the patient following closure of ASD and CABG showed a residual ASD and a shunt (Qp :Qs = 1.5. The residual ASD was closed after re-institution of cardiopulmonary bypass (CPB under cardioplegic cardiac arrest. However, the patient did not tolerate closure of the residual ASD. The CPB was re-established and under cardioplegic cardiac arrest residual ASD was reopened to create a fenestration. This time patient was weaned easily from CPB. Postoperatively, 16 hours after extubation, patient became hemodynamically unstable, the patient was electively put on ventilator and intra-aortic balloon pump. Later the patient was weaned off successfully from ventilator. Retrospective analysis of pulmonary venous flow diastolic deceleration time (PVDT D recorded during prebypass period measured 102 msec suggestive of high left atrial pressure which indicate possibility of LV failure after ASD closure.

  14. Characterization of nutrient removal and microalgal biomass production on an industrial waste-stream by application of the deceleration-stat technique.

    Science.gov (United States)

    Van Wagenen, Jon; Pape, Mathias Leon; Angelidaki, Irini

    2015-05-15

    Industrial wastewaters can serve as a nutrient and water source for microalgal production. In this study the effluent of an internal circulation (IC) reactor anaerobically treating the wastes of a biotechnology production facility were chosen as the cultivation medium for Chlorella sorokiniana in batch and continuous cultures. The aim was to evaluate the rates of nutrient removal and biomass production possible at various dilution rates. The results demonstrate that the industrial wastewater served as a highly effective microalgae culture medium and that dilution rate strongly influenced algae productivity in a short light-path photobioreactor. Batch culture on undiluted wastewater showed biomass productivity of 1.33 g L(-1)day(-1), while removing over 99% of the ammonia and phosphate from the wastewater. Deceleration-stat (D-stat) experiments performed at high and low intensities of 2100 and 200 (μmol photon m(2)s(-1)) established the optimal dilution rates to reach volumetric productivity of 5.87 and 1.67 g L(-1)day(-1) respectively. The corresponding removal rates of nitrogen were 238 and 93 mg L(-1)day(-1) and 40 and 19 mg L(-1)day(-1) for phosphorous. The yield on photons at low light intensity was as high as had been observed in any previous report indicating that the waste stream allowed the algae to grow at its full potential. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. The analysis of correlation between changes of myocardial enzymes level in serum before and after radiation and dose-volume histogram parameters of the heart%三维放疗前后血清心肌酶谱变化与心脏体积剂量相关性分析

    Institute of Scientific and Technical Information of China (English)

    丁秀平; 李红军; 李宝生; 王冬青

    2012-01-01

    目的 探讨胸部肿瘤患者三维放疗前后血清心肌酶谱改变与心脏体积剂量的相关性.方法 102例胸部肿瘤患者(肺癌68例、食管癌34例)放疗前后检测血清天冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、CK同工酶(CK-MB)、乳酸脱氢酶(LDH)及α-羟丁酸脱氢酶(α-HBDH)水平.放疗前后各种酶水平比较行配对t检验,组间比较行成组t检验.采用剂量体积直方图(DVH)参数[心脏接受≥x Gy照射体积占总体积百分比(Vx)]评价心脏体积剂量,各种酶与DVH参数相关性行Pearson法分析.结果 放疗后血清AST、CK-MB、LDH、α-HBDH水平较放疗前明显增高(19.42:27.89、14.72:19.57、178.80:217.57、140.32:176.25,t=-3.39~ -6.92,P均=0.000).调强放疗前后AST变化与V20、V25、V30相关(r=0.302~0.431,P=0.039~0.003),CK变化与V30相关(r=0.345,P=0.013),CK-MB、LDH、α-HBDH变化与V25、V30均相关(r--0.465~0.376,P=0.001~0.005);三维适形放疗前后CK-MB、LDH变化与V30相关(r=0.330、0.274,P=0.014、0.033),α-HBDH变化与V25、V30、V35相关(r=0.270~0.331,P=0.046~0.014).当放疗剂量>50 Gy时AST、LDH、α-HBDH变化与V25、V30相关(r=0.256~0.359,P=0.019~0.006),CK-MB变化与V30相关(r=0.233,P =0.037);≤50 Gy时仅V5 V45与CK变化相关(r=0.581、0.536,P=0.023、0.043).结论 心脏体积剂量与三维放疗前后心肌酶水平变化有一定相关性,提示心脏DVH参数有助于评价放疗诱导的心肌损伤.%Objective To analyze the correlation between the changes of myocardial enzyme level in serum before and after radiotherapy and dose - volume histogram ( DVH ) parameters of the heart.Methods A total of 102 patients with 68 cases of lung cancer and 34 cases of esophageal cancer were recruited.All patients received three-dimensional conformal radiotherapy (3DCRT) or intensity-modulated radiotherapy (IMRT),with the radiation beams passing through the heart.Aspertate aminotransferase (AST),creatine kinase (CK

  16. Constraints on cosmological parameters in power-law cosmology

    CERN Document Server

    Rani, Sarita; Shahalam, M; Singh, J K; Myrzakulov, R

    2014-01-01

    In this paper, we examine observational constraints on the power law cosmology; essentially dependent on two parameters $H_0$ (hubble constant) and $q$ (deceleration parameter). We investigate the constraints on these parameters using the latest 28 points of H(z) data and 580 points of Union2.1 compilation data performing a joint test with H(z) and Union2.1 compilation data. We also forecast constraints using a simulated data set for the future JDEM, supernovae survey. Our studies show that power-law cosmology tunes well with the H(z) and Union2.1 compilation data; the estimates obtained with $1\\sigma$ are in close agreement with the recent probes described in the literature. However, the constraints obtained on $$ and $$ i.e. $H_0$ average and $q$ average using the simulated data set for the future JDEM, supernovae survey are found to be inconsistent with the values obtained from the H(z) and Union2.1 SNe Ia data. We also perform the statefinder analysis and find that the power-law cosmological models approa...

  17. Constraining The Hubble Parameter Using Distance Modulus - Redshift Relation

    CERN Document Server

    Onuchukwu, C C

    2015-01-01

    Using the relation between distance modulus (m-M) and redshift (z), deduced from Friedman-Robertson-Walker (FRW) metric and assuming different values of deceleration parameter (q0). We constrained the Hubble parameter (h). The estimates of the Hubble parameters we obtained using the median values of the data obtained from NASA Extragalactic Database (NED), are: h=0.7+/-0.3 for q0=0, h=0.6+/-0.3, for q0=1 and h=0.8+/-0.3, for q0=-1. The corresponding age ({\\tau}) and size (R) of the observable universe were also estimated as: {\\tau}=15+/-1 Gyrs, R=(5+/-2)x10^3 Mpc, {\\tau}=18+/-1 Gyrs, R=(6+/-2)x10^3 Mpc and {\\tau}=13+/-1 Gyrs, R=(4+/-2)x10^3 Mpc for q0=0, q0=1 and q0=-1 respectively.

  18. Redefining solubility parameters: the partial solvation parameters.

    Science.gov (United States)

    Panayiotou, Costas

    2012-03-21

    The present work reconsiders a classical and universally accepted concept of physical chemistry, the solubility parameter. Based on the insight derived from modern quantum chemical calculations, a new definition of solubility parameter is proposed, which overcomes some of the inherent restrictions of the original definition and expands its range of applications. The original single solubility parameter is replaced by four partial solvation parameters reflecting the dispersion, the polar, the acidic and the basic character of the chemical compounds as expressed either in their pure state or in mixtures. Simple rules are adopted for the definition and calculation of these four parameters and their values are tabulated for a variety of common substances. In contrast, however, to the well known Hansen solubility parameters, their design and evaluation does not rely exclusively on the basic rule of "similarity matching" for solubility but it makes also use of the other basic rule of compatibility, namely, the rule of "complementarity matching". This complementarity matching becomes particularly operational with the sound definition of the acidic and basic components of the solvation parameter based on the third σ-moments of the screening charge distributions of the quantum mechanics-based COSMO-RS theory. The new definitions are made in a simple and straightforward manner, thus, preserving the strength and appeal of solubility parameter stemming from its simplicity. The new predictive method has been applied to a variety of solubility data for systems of pharmaceuticals and polymers. The results from quantum mechanics calculations are critically compared with the results from Abraham's acid/base descriptors.

  19. Pico: Parameters for the Impatient Cosmologist

    CERN Document Server

    Fendt, W A; Fendt, William A.; Wandelt, Benjamin D.

    2006-01-01

    We present a fast, accurate, robust and flexible method of accelerating parameter estimation. This algorithm, called Pico, can compute the CMB power spectrum and matter transfer function as well as any computationally expensive likelihoods in a few milliseconds. By removing these bottlenecks from parameter estimation codes, Pico decreases their computational time by 1 or 2 orders of magnitude. Pico has several important properties. First, it is extremely fast and accurate over a large volume of parameter space. Furthermore, its accuracy can continue to be improved by using a larger training set. This method is generalizable to an arbitrary number of cosmological parameters and to any range of l-values in multipole space. Pico is approximately 3000 times faster than CAMB for flat models, and approximately 2000 times faster then the WMAP 3 year likelihood code. In this paper, we demonstrate that using Pico to compute power spectra and likelihoods produces parameter posteriors that are very similar to those usin...

  20. Lake volume and groundwater storage variations in Tibetan Plateau's endorheic basin

    Science.gov (United States)

    Zhang, Guoqing; Yao, Tandong; Shum, C. K.; Yi, Shuang; Yang, Kun; Xie, Hongjie; Feng, Wei; Bolch, Tobias; Wang, Lei; Behrangi, Ali; Zhang, Hongbo; Wang, Weicai; Xiang, Yang; Yu, Jinyuan

    2017-06-01

    The Tibetan Plateau (TP), the highest and largest plateau in the world, with complex and competing cryospheric-hydrologic-geodynamic processes, is particularly sensitive to anthropogenic warming. The quantitative water mass budget in the TP is poorly known. Here we examine annual changes in lake area, level, and volume during 1970s-2015. We find that a complex pattern of lake volume changes during 1970s-2015: a slight decrease of -2.78 Gt yr-1 during 1970s-1995, followed by a rapid increase of 12.53 Gt yr-1 during 1996-2010, and then a recent deceleration (1.46 Gt yr-1) during 2011-2015. We then estimated the recent water mass budget for the Inner TP, 2003-2009, including changes in terrestrial water storage, lake volume, glacier mass, snow water equivalent (SWE), soil moisture, and permafrost. The dominant components of water mass budget, namely, changes in lake volume (7.72 ± 0.63 Gt yr-1) and groundwater storage (5.01 ± 1.59 Gt yr-1), increased at similar rates. We find that increased net precipitation contributes the majority of water supply (74%) for the lake volume increase, followed by glacier mass loss (13%), and ground ice melt due to permafrost degradation (12%). Other term such as SWE (1%) makes a relatively small contribution. These results suggest that the hydrologic cycle in the TP has intensified remarkably during recent decades.

  1. Volume Regulated Channels

    DEFF Research Database (Denmark)

    Klausen, Thomas Kjær

    - serves a multitude of functions in the mammalian cell, regulating the membrane potential (Em), cell volume, protein activity and the driving force for facilitated transporters giving Cl- and Cl- channels a major potential of regulating cellular function. These functions include control of the cell cycle...... of volume perturbations evolution have developed system of channels and transporters to tightly control volume homeostasis. In the past decades evidence has been mounting, that the importance of these volume regulated channels and transporters are not restricted to the defense of cellular volume......, controlled cell death and cellular migration. Volume regulatory mechanisms has long been in focus for regulating cellular proliferation and my thesis work have been focusing on the role of Cl- channels in proliferation with specific emphasis on ICl, swell. Pharmacological blockage of the ubiquitously...

  2. Two-Nucleon Systems in a Finite Volume

    Energy Technology Data Exchange (ETDEWEB)

    Briceno, Raul

    2014-11-01

    I present the formalism and methodology for determining the nucleon-nucleon scattering parameters from the finite volume spectra obtained from lattice quantum chromodynamics calculations. Using the recently derived energy quantization conditions and the experimentally determined scattering parameters, the bound state spectra for finite volume systems with overlap with the 3S1-3D3 channel are predicted for a range of volumes. It is shown that the extractions of the infinite-volume deuteron binding energy and the low-energy scattering parameters, including the S-D mixing angle, are possible from Lattice QCD calculations of two-nucleon systems with boosts of |P| <= 2pi sqrt{3}/L in volumes with spatial extents L satisfying fm <~ L <~ 14 fm.

  3. Measurable inhomogeneities in stock trading volume flow

    Science.gov (United States)

    Cortines, A. A. G.; Riera, R.; Anteneodo, C.

    2008-08-01

    We investigate the statistics of volumes of shares traded in stock markets. We show that the stochastic process of trading volumes can be understood on the basis of a mixed Poisson process at the microscopic time level. The beta distribution of the second kind (also known as q-gamma distribution), that has been proposed to describe empirical volume histograms, naturally results from our analysis. In particular, the shape of the distribution at small volumes is governed by the degree of granularity in the trading process, while the exponent controlling the tail is a measure of the inhomogeneities in market activity. Furthermore, the present case furnishes empirical evidence of how power law probability distributions can arise as a consequence of a fluctuating intrinsic parameter.

  4. Precision volume measurement system.

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Erin E.; Shugard, Andrew D.

    2004-11-01

    A new precision volume measurement system based on a Kansas City Plant (KCP) design was built to support the volume measurement needs of the Gas Transfer Systems (GTS) department at Sandia National Labs (SNL) in California. An engineering study was undertaken to verify or refute KCP's claims of 0.5% accuracy. The study assesses the accuracy and precision of the system. The system uses the ideal gas law and precise pressure measurements (of low-pressure helium) in a temperature and computer controlled environment to ratio a known volume to an unknown volume.

  5. Volume of intersection of two cones

    CERN Document Server

    Balogun, F A; Cesareo, R

    2000-01-01

    Radiation measurements utilising collimated source and detector systems invariably result in a target volume described by the overlap of their fields of view. When these collimators are cylindrical, this is derived from the volume of intersection of two cones. In general, analysis of this volume does not lend itself to a direct analytical process. Here, numerical methods of estimating the common volume of two intersecting right cones are presented. These include methods which employ, (a) a sequential scanning of an elemental volume with a predetermined size across a defined space containing the volume of interest and (b) a Monte Carlo technique. The accuracy obtainable and the execution time in the first type of algorithm depend on the size of the elemental volume (bin-size). On the other hand, these two parameters are independent of the bin-size but dependent on the number of histories sampled, for the Monte Carlo technique. At 0 deg. angle of inclination, where an analytical estimation is easily obtained, t...

  6. Active Pore Volume in Danish Peat Soils

    DEFF Research Database (Denmark)

    Forsmann, Ditte M.; Kjærgaard, Charlotte

    2012-01-01

    cm3 intact soil samples. Finally, breakthrough of tritium (3H2O) was used to construct breakthrough curves for each peat soil, which indicates the flow pattern in the soil. A mobile-immobile domain model (MIM-model) in CXTFIT was used to derive parameters describing the size of the immobile...... and mobile domains as well as the exchange between the two domains. Finally, the samples were dried in the own for determination of the bulk density. The bulk density was correlated to parameters from the MIM-model and to the macropore volume to determine, whether bulk density can be used as a key parameter....

  7. Increased culture density is linked to decelerated proliferation, prolonged G1 phase, and enhanced propensity for differentiation of self-renewing human pluripotent stem cells.

    Science.gov (United States)

    Wu, Jincheng; Fan, Yongjia; Tzanakakis, Emmanuel S

    2015-04-01

    Human pluripotent stem cells (hPSCs) display a very short G1 phase and rapid proliferation kinetics. Regulation of the cell cycle, which is linked to pluripotency and differentiation, is dependent on the stem cell environment, particularly on culture density. This link has been so far empirical and central to disparities in the growth rates and fractions of self-renewing hPSCs residing in different cycle phases. In this study, hPSC cycle progression in conjunction with proliferation and differentiation were comprehensively investigated for different culture densities. Cell proliferation decelerated significantly at densities beyond 50×10(4) cells/cm(2). Correspondingly, the G1 fraction increased from 25% up to 60% at densities greater than 40×10(4) cells/cm(2) while still hPSC pluripotency marker expression was maintained. In parallel, expression of the cycle inhibitor CDKN1A (p21) was increased, while that of p27 and p53 did not change significantly. After 4 days of culture in an unconditioned medium, greater heterogeneity was noted in the differentiation outcomes and was limited by reducing the density variation. A quantitative model was constructed for self-renewing and differentiating hPSC ensembles to gain a better understanding of the link between culture density, cycle progression, and stem cell state. Results for multiple hPSC lines and medium types corroborated experimental findings. Media commonly used for maintenance of self-renewing hPSCs exhibited the slowest kinetics of induction of differentiation (kdiff), while BMP4 supplementation led to 14-fold higher kdiff values. Spontaneous differentiation in a growth factor-free medium exhibited the largest variation in outcomes at different densities. In conjunction with the quantitative framework, our findings will facilitate rationalizing the selection of cultivation conditions for the generation of stem cell therapeutics.

  8. Experimental determination of mechanical parameters in sensorless vector-controlled induction motor drive

    Indian Academy of Sciences (India)

    V S S PAVAN KUMAR HARI; AVANISH TRIPATHI; G NARAYANAN

    2017-08-01

    High-performance industrial drives widely employ induction motors with position sensorless vector control (SLVC). The state-of-the-art SLVC is first reviewed in this paper. An improved design procedure for current and flux controllers is proposed for SLVC drives when the inverter delay is significant. The speed controller design in such a drive is highly sensitive to the mechanical parameters of the induction motor. These mechanical parameters change with the load coupled. This paper proposes a method to experimentally determine the moment of inertia and mechanical time constant of the induction motor drive along with the load driven. The proposed method is based on acceleration and deceleration of the motor under constant torque, which is achieved using a sensorless vector-controlled drive itself. Experimental results from a 5-hp induction motor drive are presented.

  9. Gamma-ray Bursts and Other Observations: Constraints on Cosmological Parameters and Dark Energy Models

    Science.gov (United States)

    Liu, J. W.; Wang, F. Y.

    2011-11-01

    We use the newly released Union2 SNe Ia dataset to constrain cosmographic parameters, namely deceleration, jerk and snap parameters (q_0,j_0 and s_0), then calibrate five luminosity relations of gamma-ray bursts (GRBs) at redshift z≤1.4. Supposing that the GRB luminosity relations do not evolve with redshift, we obtain the distance moduli of 66 high-redshift GRBs. At last, we combine the observation datasets including Cosmic Microwave Background, Baryon Acoustic Oscillations and 116 GRBs to constrain some widely-discussed dark energy models. We find the ΛCDM model is the best according to the Bayesian Information Criterion, and the JBP model is the best according to the Akaike Information Criterion.

  10. Gamma-Ray Bursts and Other Observations: Constraints on Cosmographic Parameters and Dark Energy Models

    Science.gov (United States)

    Liu, Jian-wei; Wang, Fa-yin

    2012-04-01

    We use the newly released Union2 SNe Ia dataset to constrain cosmographic parameters, namely the deceleration, jerk and snap parameters (q0, j0 and s0), then calibrate the five luminosity relations of Gamma-ray Bursts (GRBs) at redshift z ≤ 1.4. Assuming that the GRB luminosity relations do not evolve with the redshift, we obtain the distance moduli of 66 high-redshift GRBs. At last, we combine the observational datasets including the observations of the Cosmic Microwave Background (CMB), Baryon Acoustic Oscillation (BAO) and the 116 GRBs with known redshifts to constrain some widely-discussed dark energy models. We find that the ΛCDM model is the best according to the Bayesian Information Criterion (BIC), and the JBP model is the best according to the Akaike Information Criterion (AIC).

  11. Relationship between the body fat volume and sleep parameters in normal-weight school-aged children with obstructive sleep apnea hypopnea syndrome%体重正常的阻塞性睡眠呼吸暂停低通气综合征患儿体脂含量与睡眠参数相关性研究

    Institute of Scientific and Technical Information of China (English)

    张静; 张清清; 孙汀; 江帆; 殷勇; 陈洁

    2014-01-01

    Objective To investigate the effect of obstructive sleep apnea hypopnea syndrome( OSAHS ) on the body fat volume of the normal-weight children,to provide the basis for early screening and actively intervention to the obese children. Methods Consecutive OSAHS children( ages 3-7 years ) were recruited from Shanghai Children 's Medical Center as the case group,and non-OSAHS children and non-snoring healthy children as the control group. Both of the 2 groups underwent the overnight polysomnography( PSG)and assay to test the composition of the body. The case group was divided into 2 subgroups according to the apnea hypopnea index( AHI):mild OSAHS subgroup( AHI 5-10 times per hour )and moderate-severe OSAHS subgroup( AHI≥10 times per hour). The relation was analyzed between the sleep architectures,sleep arousal parameters and the body composition of the body of the three subgroups of the case group and the control group. The relation between sleep architecture,arousal parameters and the body composition of the body was studied by multiple linear regression analysis. Results There were 58 cases recruited into the case group. Mild OSAHS subgroup include 28 cases with mild OSAHS and 30 cases with moderate-severe OSAHS,and 63 cases for the control group. Age,gender and BMI Z-score were not significantly different among 4 subgroups(P>0. 05). ① There was significant difference in AHI,obstructive apnea index(OAI),nadir SpO2 and respiratory arousal index( RAI),spontaneous arousal index( SAI),sleep pressure score( SPS)in the 4 subgroups. The AHI, OAI,nadir SpO2 ,RAI and SPS of mild and moderate-severe OSAHS subgroup were siginificantly higher than those in primary snoring subgroup and healthy children subgroup. ②There was no statistically difference in fat free mass,protein,skeletal muscle, resting metabolic rate,visceral fat area,arm circumference and waist hip ratio among the 4 subgroups. Body fat volume and the percentage of body fat were different among the 4 subgroups

  12. Sintering as a process of transport of activated volume

    Directory of Open Access Journals (Sweden)

    Nikolić Nataša S.

    2002-01-01

    Full Text Available Starting with the fact that sintering is the consequence of the process of transport of activated volume, it has been shown how the kinetics of the sintering process can be defined. The activated volume was in principle defined as a parameter which describes a system’s deffectivity on an atomic level.

  13. Variable volume combustor

    Energy Technology Data Exchange (ETDEWEB)

    Ostebee, Heath Michael; Ziminsky, Willy Steve; Johnson, Thomas Edward; Keener, Christopher Paul

    2017-01-17

    The present application provides a variable volume combustor for use with a gas turbine engine. The variable volume combustor may include a liner, a number of micro-mixer fuel nozzles positioned within the liner, and a linear actuator so as to maneuver the micro-mixer fuel nozzles axially along the liner.

  14. Volumes and doses for external radiotherapy - Definitions and recommendations; Volum og doser i ekstern straaleterapi - Definisjoner og anbefalinger

    Energy Technology Data Exchange (ETDEWEB)

    Levernes, Sverre (ed.)

    2012-07-01

    The report contains definitions of volume and dose parameters for external radiotherapy. In addition the report contains recommendations for use, documentation and minimum reporting for radiotherapy of the individual patient.(Author)

  15. Volume Regulated Channels

    DEFF Research Database (Denmark)

    Klausen, Thomas Kjær

    of volume perturbations evolution have developed system of channels and transporters to tightly control volume homeostasis. In the past decades evidence has been mounting, that the importance of these volume regulated channels and transporters are not restricted to the defense of cellular volume...... but are also essential for a number of physiological processes such as proliferation, controlled cell death, migration and endocrinology. The thesis have been focusing on two Channels, namely the swelling activated Cl- channel (ICl, swell) and the transient receptor potential Vanilloid (TRPV4) channel. I: Cl......- serves a multitude of functions in the mammalian cell, regulating the membrane potential (Em), cell volume, protein activity and the driving force for facilitated transporters giving Cl- and Cl- channels a major potential of regulating cellular function. These functions include control of the cell cycle...

  16. LHC Report: a brief deceleration

    CERN Multimedia

    Rossano Giachino & Markus Albert

    2015-01-01

    The LHC has now transitioned from powering tests to the machine checkout phase. This phase involves the full-scale tests of all systems in preparation for beam. Early last Saturday morning, during the ramp-down, an earth fault developed in the main dipole circuit. Full evaluation of the situation is ongoing.   The various systems are put through their operational paces from the CCC. This includes important tests of the beam dump system and full-scale tests of the beam interlock system (BIS) and its many inputs from other systems around the ring. All magnetic circuits are driven through the ramp, squeeze, ramp-down, and pre-cycle along with the collimators and RF. Instrumentation, feedbacks, and the control system are also stress tested. Inevitably there is some final frantic debugging but, up to now, things seem to be in reasonable shape. The machine checkout is an important coming together of all LHC systems. During this final phase before beam, the operations team tests all of the LHC subsystem...

  17. Computer-assisted venous thrombosis volume quantification.

    Science.gov (United States)

    Puentes, John; Dhibi, Mounir; Bressollette, Luc; Guias, Bruno; Solaiman, Basel

    2009-03-01

    Venous thrombosis (VT) volume assessment, by verifying its risk of progression when anticoagulant or thrombolytic therapies are prescribed, is often necessary to screen life-threatening complications. Commonly, VT volume estimation is done by manual delineation of few contours in the ultrasound (US) image sequence, assuming that the VT has a regular shape and constant radius, thus producing significant errors. This paper presents and evaluates a comprehensive functional approach based on the combination of robust anisotropic diffusion and deformable contours to calculate VT volume in a more accurate manner when applied to freehand 2-D US image sequences. Robust anisotropic filtering reduces image speckle noise without generating incoherent edge discontinuities. Prior knowledge of the VT shape allows initializing the deformable contour, which is then guided by the noise-filtering outcome. Segmented contours are subsequently used to calculate VT volume. The proposed approach is integrated into a system prototype compatible with existing clinical US machines that additionally tracks the acquired images 3-D position and provides a dense Delaunay triangulation required for volume calculation. A predefined robust anisotropic diffusion and deformable contour parameter set enhances the system usability. Experimental results pertinence is assessed by comparison with manual and tetrahedron-based volume computations, using images acquired by two medical experts of eight plastic phantoms and eight in vitro VTs, whose independently measured volume is the reference ground truth. Results show a mean difference between 16 and 35 mm(3) for volumes that vary from 655 to 2826 mm(3). Two in vivo VT volumes are also calculated to illustrate how this approach could be applied in clinical conditions when the real value is unknown. Comparative results for the two experts differ from 1.2% to 10.08% of the smallest estimated value when the image acquisition cadences are similar.

  18. Estimating Cosmological Parameter Covariance

    CERN Document Server

    Taylor, Andy

    2014-01-01

    We investigate the bias and error in estimates of the cosmological parameter covariance matrix, due to sampling or modelling the data covariance matrix, for likelihood width and peak scatter estimators. We show that these estimators do not coincide unless the data covariance is exactly known. For sampled data covariances, with Gaussian distributed data and parameters, the parameter covariance matrix estimated from the width of the likelihood has a Wishart distribution, from which we derive the mean and covariance. This mean is biased and we propose an unbiased estimator of the parameter covariance matrix. Comparing our analytic results to a numerical Wishart sampler of the data covariance matrix we find excellent agreement. An accurate ansatz for the mean parameter covariance for the peak scatter estimator is found, and we fit its covariance to our numerical analysis. The mean is again biased and we propose an unbiased estimator for the peak parameter covariance. For sampled data covariances the width estimat...

  19. Parameter estimation in stochastic differential equations

    CERN Document Server

    Bishwal, Jaya P N

    2008-01-01

    Parameter estimation in stochastic differential equations and stochastic partial differential equations is the science, art and technology of modelling complex phenomena and making beautiful decisions. The subject has attracted researchers from several areas of mathematics and other related fields like economics and finance. This volume presents the estimation of the unknown parameters in the corresponding continuous models based on continuous and discrete observations and examines extensively maximum likelihood, minimum contrast and Bayesian methods. Useful because of the current availability of high frequency data is the study of refined asymptotic properties of several estimators when the observation time length is large and the observation time interval is small. Also space time white noise driven models, useful for spatial data, and more sophisticated non-Markovian and non-semimartingale models like fractional diffusions that model the long memory phenomena are examined in this volume.

  20. Bayesian Statistics and Parameter Constraints on the Generalized Chaplygin Gas Model using SNe Ia Data

    CERN Document Server

    Colistete, R C; Goncalves, S V B

    2004-01-01

    The type Ia supernovae (SNe Ia) observational data are used to estimate the parameters of a cosmological model with cold dark matter and the generalized Chaplygin gas model (GCGM). The GCGM depends essentially on five parameters: the Hubble constant, the parameter $\\bar{A}$ related to the velocity of the sound, the equation of state parameter $\\alpha$, the curvature of the Universe and the fraction density of the generalized Chaplygin gas (or the cold dark matter). The parameter $\\alpha$ is allowed to take negative values and to be greater than 1. The Bayesian parameter estimation yields $\\alpha = - 0.86^{+6.01}_{-0.15}$, $H_0 = 62.0^{+1.32}_{-1.42} km/Mpc.s$, $\\Omega _{k0}=-1.26_{-1.42}^{+1.32}$, $\\Omega_{m0} = 0.00^{+0.86}_{-0.00}$, $\\Omega_{c0} = 1.39^{+1.21}_{-1.25}$, $\\bar A =1.00^{+0.00}_{-0.39}$, $t_0 = 15.3^{+4.2}_{-3.2}$ and $q_0 = -0.80^{+0.86}_{-0.62}$, where $t_0$ is the age of the Universe and $q_0$ is the value of the deceleration parameter today. Our results indicate that a Universe completely ...