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  1. Modeling CICR in rat ventricular myocytes: voltage clamp studies

    Directory of Open Access Journals (Sweden)

    Palade Philip T

    2010-11-01

    Full Text Available Abstract Background The past thirty-five years have seen an intense search for the molecular mechanisms underlying calcium-induced calcium-release (CICR in cardiac myocytes, with voltage clamp (VC studies being the leading tool employed. Several VC protocols including lowering of extracellular calcium to affect Ca2+ loading of the sarcoplasmic reticulum (SR, and administration of blockers caffeine and thapsigargin have been utilized to probe the phenomena surrounding SR Ca2+ release. Here, we develop a deterministic mathematical model of a rat ventricular myocyte under VC conditions, to better understand mechanisms underlying the response of an isolated cell to calcium perturbation. Motivation for the study was to pinpoint key control variables influencing CICR and examine the role of CICR in the context of a physiological control system regulating cytosolic Ca2+ concentration ([Ca2+]myo. Methods The cell model consists of an electrical-equivalent model for the cell membrane and a fluid-compartment model describing the flux of ionic species between the extracellular and several intracellular compartments (cell cytosol, SR and the dyadic coupling unit (DCU, in which resides the mechanistic basis of CICR. The DCU is described as a controller-actuator mechanism, internally stabilized by negative feedback control of the unit's two diametrically-opposed Ca2+ channels (trigger-channel and release-channel. It releases Ca2+ flux into the cyto-plasm and is in turn enclosed within a negative feedback loop involving the SERCA pump, regulating[Ca2+]myo. Results Our model reproduces measured VC data published by several laboratories, and generates graded Ca2+ release at high Ca2+ gain in a homeostatically-controlled environment where [Ca2+]myo is precisely regulated. We elucidate the importance of the DCU elements in this process, particularly the role of the ryanodine receptor in controlling SR Ca2+ release, its activation by trigger Ca2+, and its

  2. Potassium Chloride Versus Voltage Clamp Contractures in Ventricular Muscle

    Science.gov (United States)

    Morad, M.; Reeck, S.; Rao, M.

    1981-01-01

    In frog ventricle, developed tension was markedly larger in response to depolarization caused by a voltage clamp step than to depolarization induced by high concentrations of potassium chloride. Measurement of extracellular potassium activity at the surface and at the depth of muscle during the development of contractures showed that the diffusion of potassium is much slower than the spread of depolarization through the cross section of muscle. These two observations suggest that competition between the depolarizing and the negative inotropic effects of an increase in the extracellular potassium ion concentration may determine the time course and magnitude of contractile tension in heart muscle.

  3. Investigating ion channel conformational changes using voltage clamp fluorometry.

    Science.gov (United States)

    Talwar, Sahil; Lynch, Joseph W

    2015-11-01

    Ion channels are membrane proteins whose functions are governed by conformational changes. The widespread distribution of ion channels, coupled with their involvement in most physiological and pathological processes and their importance as therapeutic targets, renders the elucidation of these conformational mechanisms highly compelling from a drug discovery perspective. Thanks to recent advances in structural biology techniques, we now have high-resolution static molecular structures for members of the major ion channel families. However, major questions remain to be resolved about the conformational states that ion channels adopt during activation, drug modulation and desensitization. Patch-clamp electrophysiology has long been used to define ion channel conformational states based on functional criteria. It achieves this by monitoring conformational changes at the channel gate and cannot detect conformational changes occurring in regions distant from the gate. Voltage clamp fluorometry involves labelling cysteines introduced into domains of interest with environmentally sensitive fluorophores and inferring structural rearrangements from voltage or ligand-induced fluorescence changes. Ion channel currents are monitored simultaneously to verify the conformational status. By defining real time conformational changes in domains distant from the gate, this technique provides unexpected new insights into ion channel structure and function. This review aims to summarise the methodology and highlight recent innovative applications of this powerful technique. This article is part of the Special Issue entitled 'Fluorescent Tools in Neuropharmacology'. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Application of active electrode compensation to perform continuous voltage-clamp recordings with sharp microelectrodes.

    Science.gov (United States)

    Gómez-González, J F; Destexhe, A; Bal, T

    2014-10-01

    Electrophysiological recordings of single neurons in brain tissues are very common in neuroscience. Glass microelectrodes filled with an electrolyte are used to impale the cell membrane in order to record the membrane potential or to inject current. Their high resistance induces a high voltage drop when passing current and it is essential to correct the voltage measurements. In particular, for voltage clamping, the traditional alternatives are two-electrode voltage-clamp technique or discontinuous single electrode voltage-clamp (dSEVC). Nevertheless, it is generally difficult to impale two electrodes in a same neuron and the switching frequency is limited to low frequencies in the case of dSEVC. We present a novel fully computer-implemented alternative to perform continuous voltage-clamp recordings with a single sharp-electrode. To reach such voltage-clamp recordings, we combine an active electrode compensation algorithm (AEC) with a digital controller (AECVC). We applied two types of control-systems: a linear controller (proportional plus integrative controller) and a model-based controller (optimal control). We compared the performance of the two methods to dSEVC using a dynamic model cell and experiments in brain slices. The AECVC method provides an entirely digital method to perform continuous recording and smooth switching between voltage-clamp, current clamp or dynamic-clamp configurations without introducing artifacts.

  5. Suppression of Spiral Waves by Voltage Clamp Techniques in a Conductance-Based Cardiac Tissue Model

    International Nuclear Information System (INIS)

    Lian-Chun, Yu; Guo-Yong, Zhang; Yong, Chen; Jun, Ma

    2008-01-01

    A new control method is proposed to control the spatio-temporal dynamics in excitable media, which is described by the Morris–Lecar cells model. It is confirmed that successful suppression of spiral waves can be obtained by spatially clamping the membrane voltage of the excitable cells. The low voltage clamping induces breakup of spiral waves and the fragments are soon absorbed by low voltage obstacles, whereas the high voltage clamping generates travel waves that annihilate spiral waves through collision with them. However, each method has its shortcomings. Furthermore, a two-step method that combines both low and high voltage clamp techniques is then presented as a possible way of out this predicament. (cross-disciplinary physics and related areas of science and technology)

  6. Limitations of the dual voltage clamp method in assaying conductance and kinetics of gap junction channels

    NARCIS (Netherlands)

    Wilders, R.; Jongsma, H. J.

    1992-01-01

    The electrical properties of gap junctions in cell pairs are usually studied by means of the dual voltage clamp method. The voltage across the junctional channels, however, cannot be controlled adequately due to an artificial resistance and a natural resistance, both connected in series with the gap

  7. Quantitative analysis of dual whole-cell voltage-clamp determination of gap junctional conductance

    NARCIS (Netherlands)

    van Rijen, H. V.; Wilders, R.; van Ginneken, A. C.; Jongsma, H. J.

    1998-01-01

    The dual whole-cell voltage-clamp technique is used widely for determination of kinetics and conductance of gap junctions. The use of this technique may, however, occasion to considerable errors. We have analysed the errors in steady state junctional conductance measurements under different

  8. Direct-conversion switching-mode audio power amplifier with active capacitive voltage clamp

    DEFF Research Database (Denmark)

    Ljusev, Petar; Andersen, Michael Andreas E.

    2005-01-01

    This paper discusses the advantages and problems when implementing direct energy conversion switching-mode audio power amplifiers. It is shown that the total integration of the power supply and Class D audio power amplifier into one compact direct converter can simplify the design, increase...... efficiency, reduce the product volume and lower its cost. As an example, the principle of operation and the measurements made on a direct-conversion switching-mode audio power amplifier with active capacitive voltage clamp are presented....

  9. Limitations of the dual voltage clamp method in assaying conductance and kinetics of gap junction channels

    OpenAIRE

    Wilders, R.; Jongsma, H.J.

    1992-01-01

    The electrical properties of gap junctions in cell pairs are usually studied by means of the dual voltage clamp method. The voltage across the junctional channels, however, cannot be controlled adequately due to an artificial resistance and a natural resistance, both connected in series with the gap junction. The access resistances to the cell interior of the recording pipettes make up the artificial resistance. The natural resistance consists of the cytoplasmic access resistances to the tigh...

  10. Direct-conversion switching-mode audio power amplifier with active capacitive voltage clamp

    Energy Technology Data Exchange (ETDEWEB)

    Ljusev, P.; Andersen, Michael A.E.

    2005-07-01

    This paper discusses the advantages and problems when implementing direct energy conversion switching-mode audio power amplifiers. It is shown that the total integration of the power supply and Class D audio power amplifier into one compact direct converter can simplify design, increase efficiency and integration level, reduce product volume and lower its cost. As an example, the principle of operation and the measurements made on a direct-conversion switching-mode audio power amplifier with active capacitive voltage clamp are presented. (au)

  11. Equivalent circuit of frog atrial tissue as determined by voltage clamp-unclamp experiments.

    Science.gov (United States)

    Tarr, M; Trank, J

    1971-11-01

    The equivalent circuit that has been used in the analysis of nerve voltage-clamp data is that of the membrane capacity in parallel with the membrane resistance. Voltage-clamp experiments on frog atrial tissue indicate that this circuit will not suffice for this cardiac tissue. The change in membrane current associated with a step change in membrane potential does not show a rapid spike of capacitive current as would be expected for the simple parallel resistance-capacitance network. Rather, there is a step change in current followed by an exponential decay in current with a time constant of about 1 msec. This relatively slow capacitive charging current suggests that there is a resistance in series with the membrane capacity. A possible equivalent circuit is that of a series resistance external to the parallel resistance-capacitance network of the cell membranes. Another possible circuit assumes that the series resistance is an integral part of the cell membrane. The data presented in this paper demonstrate that the equivalent circuit of a bundle of frog atrial muscle is that of an external resistance in series with the cell membranes.

  12. The Anion Paradox in Sodium Taste Reception: Resolution by Voltage-Clamp Studies

    Science.gov (United States)

    Ye, Qing; Heck, Gerard L.; Desimone, John A.

    1991-11-01

    Sodium salts are potent taste stimuli, but their effectiveness is markedly dependent on the anion, with chloride yielding the greatest response. The cellular mechanisms that mediate this phenomenon are not known. This "anion paradox" has been resolved by considering the field potential that is generated by restricted electrodiffusion of the anion through paracellular shunts between taste-bud cells. Neural responses to sodium chloride, sodium acetate, and sodium gluconate were studied while the field potential was voltage-clamped. Clamping at electronegative values eliminated the anion effect, whereas clamping at electropositive potentials exaggerated it. Thus, field potentials across the lingual epithelium modulate taste reception, indicating that the functional unit of taste reception includes the taste cell and its paracellular microenvironment.

  13. Excitation contraction uncoupling by high intracellular [Ca2+] in frog skeletal muscle: a voltage clamp study.

    Science.gov (United States)

    Olivera, J Fernando; Pizarro, Gonzalo

    2016-10-01

    Raising the intracellular [Ca 2+ ] ([Ca 2+ ] i ) was previously found to produce uncoupling between the electrical depolarization of the transverse tubules and contraction in skinned muscle fibers. Here we study the effect of elevated [Ca 2+ ] i in voltage clamped cut fibers of frog skeletal muscle to establish how the charge movement, a measure of the activation of the dihydropyridine receptors (DHPR)-voltage sensors, and Ca 2+ release, a consequence of the opening of the ryanodine receptor (RyR)-release channels, were affected. [Ca 2+ ] i was raised by various procedures (pharmacological release from the sarcoplasmic reticulum, application of high [Ca 2+ ] i intracellular solution, permeabilization of the plasma membrane by a Ca 2+ ionophore) all of which produced impairment of excitation-contraction coupling. The charge movement was reduced from 20.2 ± 1.24 to 9.9 ± 0.94 nC/μF meanwhile the Ca 2+ release flux was reduced from 13.5 + 0.7 to 2.2 ± 0.3 μM/ms (n = 33). This suggests that a significant fraction of the DHPRs that remained functional, could not activate RyRs, and were therefore presumably disconnected. These results are broadly consistent with the original reports in skinned fibers. Uncoupling was prevented by the addition to the intracellular solution of the protease inhibitor leupeptin. In approximately 40 % of the uncoupled cells we observed that the [Ca 2+ ] i transient continued to rise after the voltage clamp pulse was turned off. This loss of control by membrane voltage suggests that the uncoupled release channels might have another mechanism of activation, likely by Ca 2+ .

  14. Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry.

    Science.gov (United States)

    Zhu, Wandi; Varga, Zoltan; Silva, Jonathan R

    2016-01-01

    Very recently, voltage-clamp fluorometry (VCF) protocols have been developed to observe the membrane proteins responsible for carrying the ventricular ionic currents that form the action potential (AP), including those carried by the cardiac Na(+) channel, NaV1.5, the L-type Ca(2+) channel, CaV1.2, the Na(+)/K(+) ATPase, and the rapid and slow components of the delayed rectifier, KV11.1 and KV7.1. This development is significant, because VCF enables simultaneous observation of ionic current kinetics with conformational changes occurring within specific channel domains. The ability gained from VCF, to connect nanoscale molecular movement to ion channel function has revealed how the voltage-sensing domains (VSDs) control ion flux through channel pores, mechanisms of post-translational regulation and the molecular pathology of inherited mutations. In the future, we expect that this data will be of great use for the creation of multi-scale computational AP models that explicitly represent ion channel conformations, connecting molecular, cell and tissue electrophysiology. Here, we review the VCF protocol, recent results, and discuss potential future developments, including potential use of these experimental findings to create novel computational models. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Characterization of heterologously expressed transporter genes by patch- and voltage-clamp methods: Application to cyclic nucleotide-dependent responses

    KAUST Repository

    Lemtiri-Chlieh, Fouad; Ali, Rashid Ayesha

    2013-01-01

    The application of patch- and voltage-clamp methods to study ion transport can be limited by many hurdles: the size of the cells to be patched and/or stabbed, the subcellular localization of the molecule of interest, and its density of expression that could be too low even in their own native environment. Functional expression of genes using recombinant DNA technology not only overcomes those hurdles but also affords additional and elegant investigations such as single-point mutation studies and subunit associations/regulations. In this chapter, we give a step-by-step description of two electrophysiological methods, patch clamp and two-electrode voltage clamp (TEVC), that are routinely used in combination with heterologous gene expression to assist researchers interested in the identification and characterization of ion transporters. We describe how to (1) obtain and maintain the cells suitable for the use with each of the above-mentioned methods (i.e., HEK-293 cells and yeast spheroplasts to use with the patch-clamp methodology and Xenopus laevis oocytes with TEVC), (2) transfect/inject them with the gene of interest, and (3) record ion transport activities. © Springer Science+Business Media New York 2013.

  16. Characterization of heterologously expressed transporter genes by patch- and voltage-clamp methods: Application to cyclic nucleotide-dependent responses

    KAUST Repository

    Lemtiri-Chlieh, Fouad

    2013-09-03

    The application of patch- and voltage-clamp methods to study ion transport can be limited by many hurdles: the size of the cells to be patched and/or stabbed, the subcellular localization of the molecule of interest, and its density of expression that could be too low even in their own native environment. Functional expression of genes using recombinant DNA technology not only overcomes those hurdles but also affords additional and elegant investigations such as single-point mutation studies and subunit associations/regulations. In this chapter, we give a step-by-step description of two electrophysiological methods, patch clamp and two-electrode voltage clamp (TEVC), that are routinely used in combination with heterologous gene expression to assist researchers interested in the identification and characterization of ion transporters. We describe how to (1) obtain and maintain the cells suitable for the use with each of the above-mentioned methods (i.e., HEK-293 cells and yeast spheroplasts to use with the patch-clamp methodology and Xenopus laevis oocytes with TEVC), (2) transfect/inject them with the gene of interest, and (3) record ion transport activities. © Springer Science+Business Media New York 2013.

  17. Voltage clamp methods for the study of membrane currents and SR Ca2+ release in adult skeletal muscle fibres

    Science.gov (United States)

    Hernández-Ochoa, Erick O.; Schneider, Martin F.

    2012-01-01

    Skeletal muscle excitation-contraction (E-C)1 coupling is a process composed of multiple sequential stages, by which an action potential triggers sarcoplasmic reticulum (SR)2 Ca2+ release and subsequent contractile activation. The various steps in the E-C coupling process in skeletal muscle can be studied using different techniques. The simultaneous recordings of sarcolemmal electrical signals and the accompanying elevation in myoplasmic Ca2+, due to depolarization-initiated SR Ca2+ release in skeletal muscle fibres, have been useful to obtain a better understanding of muscle function. In studying the origin and mechanism of voltage dependency of E-C coupling a variety of different techniques have been used to control the voltage in adult skeletal fibres. Pioneering work in muscles isolated from amphibians or crustaceans used microelectrodes or ‘high resistance gap’ techniques to manipulate the voltage in the muscle fibres. The development of the patch clamp technique and its variant, the whole-cell clamp configuration that facilitates the manipulation of the intracellular environment, allowed the use of the voltage clamp techniques in different cell types, including skeletal muscle fibres. The aim of this article is to present an historical perspective of the voltage clamp methods used to study skeletal muscle E-C coupling as well as to describe the current status of using the whole-cell patch clamp technique in studies in which the electrical and Ca2+ signalling properties of mouse skeletal muscle membranes are being investigated. PMID:22306655

  18. Isolated PWM DC-AC SICAM with an active capacitive voltage clamp[Pulse Density Modulated; Pulse Width Modulation

    Energy Technology Data Exchange (ETDEWEB)

    Ljusev, P.

    2004-03-15

    In this report an isolated PWM DC-AC SICAM with an active capacitive voltage clamp is presented. AC-DC power supply is implemented in its simplest form: diode rectifier followed by a medium-size charge-storage capacitors and possibly with an EMC filter on the mains entrance. Isolation from the AC mains is achieved using a high frequency (HF) transformer, whose voltages are not audio-modulated. The latter simplifies the design and is expected to have many advantages over the approach where the transformer voltages are modulated in regards to the audio signal reference. Input stage is built as a DC-AC inverter (push-pull, half-bridge or a full-bridge) and operated with 50% duty cycle, with all the challenges to avoid transformer saturation and obtain symmetrical operation. On the secondary side the output section is implemented as rectifier+inverter AC-AC stage, i.e. a true bidirectional bridge, which operation is aimed towards amplification of the audio signal. In order to solve the problem with the commutation of the load current, a dead time between the incoming and outgoing bidirectional switch is implemented, while a capacitive voltage clamp is used to keep the induced overvoltage to reasonable levels. The energy stored in the clamping capacitor is not wasted as in the dissipative clamps, but is rather transferred back to the primary side for further processing using an auxiliary isolated single-switch converter, i.e. an active clamping technique is used. (au)

  19. Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ.

    Science.gov (United States)

    Pohl, P; Saparov, S M; Borgnia, M J; Agre, P

    2001-08-14

    Aquaporins are membrane channels selectively permeated by water or water plus glycerol. Conflicting reports have described ion conductance associated with some water channels, raising the question of whether ion conductance is a general property of the aquaporin family. To clarify this question, a defined system was developed to simultaneously measure water permeability and ion conductance. The Escherichia coli water channel aquaporin-Z (AqpZ) was studied, because it is a highly stable tetramer. Planar lipid bilayers were formed from unilamellar vesicles containing purified AqpZ. The hydraulic conductivity of bilayers made from the total extract of E. coli lipids increased 3-fold if reconstituted with AqpZ, but electric conductance was unchanged. No channel activity was detected under voltage-clamp conditions, indicating that less than one in 10(9) transport events is electrogenic. Microelectrode measurements were simultaneously undertaken adjacent to the membrane. Changes in sodium concentration profiles accompanying transmembrane water flow permitted calculation of the activation energies: 14 kcal/mol for protein-free lipid bilayers and 4 kcal/mol for lipid bilayers containing AqpZ. Neither the water permeability nor the electric conductivity exhibited voltage dependence. This sensitive system demonstrated that AqpZ is permeated by water but not charged ions and should permit direct analyses of putative electrogenic properties of other aquaporins.

  20. Accurate measurement of junctional conductance between electrically coupled cells with dual whole-cell voltage-clamp under conditions of high series resistance.

    Science.gov (United States)

    Hartveit, Espen; Veruki, Margaret Lin

    2010-03-15

    Accurate measurement of the junctional conductance (G(j)) between electrically coupled cells can provide important information about the functional properties of coupling. With the development of tight-seal, whole-cell recording, it became possible to use dual, single-electrode voltage-clamp recording from pairs of small cells to measure G(j). Experiments that require reduced perturbation of the intracellular environment can be performed with high-resistance pipettes or the perforated-patch technique, but an accompanying increase in series resistance (R(s)) compromises voltage-clamp control and reduces the accuracy of G(j) measurements. Here, we present a detailed analysis of methodologies available for accurate determination of steady-state G(j) and related parameters under conditions of high R(s), using continuous or discontinuous single-electrode voltage-clamp (CSEVC or DSEVC) amplifiers to quantify the parameters of different equivalent electrical circuit model cells. Both types of amplifiers can provide accurate measurements of G(j), with errors less than 5% for a wide range of R(s) and G(j) values. However, CSEVC amplifiers need to be combined with R(s)-compensation or mathematical correction for the effects of nonzero R(s) and finite membrane resistance (R(m)). R(s)-compensation is difficult for higher values of R(s) and leads to instability that can damage the recorded cells. Mathematical correction for R(s) and R(m) yields highly accurate results, but depends on accurate estimates of R(s) throughout an experiment. DSEVC amplifiers display very accurate measurements over a larger range of R(s) values than CSEVC amplifiers and have the advantage that knowledge of R(s) is unnecessary, suggesting that they are preferable for long-duration experiments and/or recordings with high R(s). Copyright (c) 2009 Elsevier B.V. All rights reserved.

  1. Technical characterization of dialysis fluid flow and mass transfer rate in dialyzers with various filtration coefficients using dimensionless correlation equation.

    Science.gov (United States)

    Fukuda, Makoto; Yoshimura, Kengo; Namekawa, Koki; Sakai, Kiyotaka

    2017-06-01

    The objective of the present study is to evaluate the effect of filtration coefficient and internal filtration on dialysis fluid flow and mass transfer coefficient in dialyzers using dimensionless mass transfer correlation equations. Aqueous solution of vitamin B 12 clearances were obtained for REXEED-15L as a low flux dialyzer, and APS-15EA and APS-15UA as high flux dialyzers. All the other design specifications were identical for these dialyzers except for filtration coefficient. The overall mass transfer coefficient was calculated, moreover, the exponents of Reynolds number (Re) and film mass transfer coefficient of the dialysis-side fluid (k D ) for each flow rate were derived from the Wilson plot and dimensionless correlation equation. The exponents of Re were 0.4 for the low flux dialyzer whereas 0.5 for the high flux dialyzers. Dialysis fluid of the low flux dialyzer was close to laminar flow because of its low filtration coefficient. On the other hand, dialysis fluid of the high flux dialyzers was assumed to be orthogonal flow. Higher filtration coefficient was associated with higher k D influenced by mass transfer rate through diffusion and internal filtration. Higher filtration coefficient of dialyzers and internal filtration affect orthogonal flow of dialysis fluid.

  2. Effects of trimethoprim-sulfadiazine and detomidine on the function of equine Kv 11.1 channels in a two-electrode voltage-clamp (TEVC) oocyte model.

    Science.gov (United States)

    Trachsel, D S; Tejada, M A; Groesfjeld Christensen, V; Pedersen, P J; Kanters, J K; Buhl, R; Calloe, K; Klaerke, D A

    2018-03-22

    The long QT syndrome (LQTS) is a channelopathy that can lead to severe arrhythmia and sudden cardiac death. Pharmacologically induced LQTS is caused by interaction between drugs and potassium channels, especially the K v 11.1 channel. Due to such interactions, numerous drugs have been withdrawn from the market or are administered with precautions in human medicine. However, some compounds, such as trimethoprim-sulfonamide combinations are still widely used in veterinarian medicine. Therefore, we investigate the effect of trimethoprim-sulfadiazine (TMS), trimethoprim, sulfadiazine, and detomidine on equine-specific K v 11.1 channels. K v 11.1 channels cloned from equine hearts were heterologously expressed in Xenopus laevis oocytes, and whole cell currents were measured by two-electrode voltage-clamp before and after drug application. TMS blocked equine K v 11.1 current with an IC 50 of 3.74 mm (95% CI: 2.95-4.73 mm) and affected the kinetics of activation and inactivation. Similar was found for trimethoprim but not for sulfadiazine, suggesting the effect is due to trimethoprim. Detomidine did not affect equine K v 11.1 current. Thus, equine K v 11.1 channels are also susceptible to pharmacological block, indicating that some drugs may have the potential to affect repolarization in horse. However, in vivo studies are needed to assess the potential risk of these drugs to induce equine LQTS. © 2018 The Authors. Journal of Veterinary Pharmacology and Therapeutics Published by John Wiley & Sons Ltd.

  3. Formation of Blood Foam in the Air Trap During Hemodialysis Due to Insufficient Automatic Priming of Dialyzers.

    Science.gov (United States)

    Jonsson, Per; Lindmark, Lorentz; Axelsson, Jan; Karlsson, Lars; Lundberg, Lennart; Stegmayr, Bernd

    2018-05-01

    problems. Meanwhile caution is warranted for the combined use of dialysis devices and dialyzers with incompatible automatic priming. © 2018 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

  4. Assessment of dialyzer surface in online hemodiafiltration; objective choice of dialyzer surface area

    Directory of Open Access Journals (Sweden)

    Francisco Maduell

    2015-05-01

    Conclusion: The increase in 40% and 80% of dialyzer surface area entails an increase in convective volume of 6 and 16% respectively, showing minimal differences both in convective volume and clearance capacity when UFC was greater than 45 mL/h/mmHg. It is advisable to optimise dialyser efficiency to the smallest surface area possible, adjusting treatment prescription.

  5. Dialyzability of gadodiamide in hemodialysis patients

    International Nuclear Information System (INIS)

    Saitoh, Tomoya; Tanaka, Yoshiaki; Kuno, Tsutomu; Nagura, Yuji; Hayasaka, Kazumasa

    2006-01-01

    The aim of this study was to evaluate the contrast enhancement, pharmacokinetics, dialyzability, and safety of gadodiamide in patients on hemodialysis. Thirteen hemodialysis patients with abdominal disease were examined after receiving intravenous gadodiamide (0.1 mmol/kg body weight) by magnetic resonance imaging (MRI) and were dialyzed at 1, 3, 5, and 8 days. Blood samples were obtained immediately before, during, and at the end of the first hemodialysis session and immediately before and at the end of the next three sessions. The complete blood count, blood biochemistry, β 2 -microglobulin, and gadolinium were measured. Dialysis of urea, creatinine, and gadolinium during the first hemodialysis session was assessed. Precontrast and postcontrast MRI and Gd-enhanced MR angiography (MRA) images were reviewed and visually evaluated by two radiologists; their evaluation was based on consensus. Gadodiamide did not cause any changes in renal function. An average of 73.8%, 92.4%, and 98.9% of the gadodiamide dose was eliminated by the end of the first, second, and third hemodialysis sessions, respectively. The average half-time of gadodiamide was 1.93 h (SD 0.55). The mean clearance of gadodiamide during hemodialysis was 63.5 ml/min (SD 21.9). There were no side effects related to the injection of gadodiamide. In all cases, diagnosable MRI and MRA images were obtained after gadodiamide injection in the hemodialysis patients. In hemodialysis patients, gadodiamide achieves diagnosable images. It is dialyzable and can be used safely without measures to increase excretion. (author)

  6. Effect of dialyzer geometry on granulocyte and complement activation.

    Science.gov (United States)

    Schaefer, R M; Heidland, A; Hörl, W H

    1987-01-01

    During hemodialysis with cuprophan membranes, the complement system as well as leukocytes become activated. In order to clarify the role of dialyzer geometry, the effect of hollow-fiber versus flat-sheet dialyzers and of different surface areas on C3a generation and leukocyte degranulation was investigated. Plasma levels of leukocyte elastase in complex with alpha 1-proteinase inhibitor were significantly increased after 1 h (+55%) and 3 h (+62%) of hemodialysis with flat-sheet dialyzers as compared to hollow-fiber devices. In addition, plasma levels of lactoferrin, released from the specific granules of leukocytes during activation, were significantly higher (+42%) 3 h after the onset of dialysis treatment with flat-sheet than with hollow-fiber dialyzers. With respect to surface area, larger dialyzers tended to cause more release of leukocyte elastase as compared to dialyzers with smaller surface areas, irrespectively of the configuration of the dialyzer used. On the other hand, activation of the complement system, as measured by the generation of C3a-desarg, did not differ with both types of configurations. The same held true for leukopenia, which was almost identical for hollow-fiber and flat-sheet dialyzers. From these findings two lines of evidence emerge: First, not only the type of membrane material used in a dialyzer may influence its biocompatibility, but the geometry of the extracorporeal device also determines the degree of compatibility. Hence, the extent of leukocyte activation correlated with both configuration of the dialyzer and surface area of the membrane.(ABSTRACT TRUNCATED AT 250 WORDS)

  7. Dialyzer Reuse and Outcomes of High Flux Dialysis.

    Science.gov (United States)

    Argyropoulos, Christos; Roumelioti, Maria-Eleni; Sattar, Abdus; Kellum, John A; Weissfeld, Lisa; Unruh, Mark L

    2015-01-01

    The bulk of randomized trial evidence for the expanding use of High Flux (HF) hemodialysis worldwide comes from two randomized controlled trials, one of which (HEMODIALYSIS, HEMO) allowed, while the other (Membrane Outcomes Permeability, MPO) excluded, the reuse of membranes. It is not known whether dialyzer reuse has a differential impact on outcomes with HF vs low flyx (LF) dialyzers. Proportional Hazards Models and Joint Models for longitudinal measures and survival outcomes were used in HEMO to analyze the relationship between β2-microglobulin (β2M) concentration, flux, and reuse. Meta-analysis and regression techniques were used to synthesize the evidence for HF dialysis from HEMO and MPO. In HEMO, minimally reused (membranes (p for interaction between reuse and flux benefit with more extensively reused dialyzers. Meta-regression of HEMO and MPO estimated an adjusted HR of 0.63 (95% CI: 0.51-0.78) for non-reused HF dialyzers compared with non-reused LF membranes. This secondary analysis and synthesis of two large hemodialysis trials supports the widespread use of HF dialyzers in clinical hemodialysis over the last decade. A mechanistic understanding of the effects of HF dialysis and the reuse process on dialyzers may suggest novel biomarkers for uremic toxicity and may accelerate membrane technology innovations that will improve patient outcomes.

  8. Dialyzer Reuse and Outcomes of High Flux Dialysis.

    Directory of Open Access Journals (Sweden)

    Christos Argyropoulos

    Full Text Available The bulk of randomized trial evidence for the expanding use of High Flux (HF hemodialysis worldwide comes from two randomized controlled trials, one of which (HEMODIALYSIS, HEMO allowed, while the other (Membrane Outcomes Permeability, MPO excluded, the reuse of membranes. It is not known whether dialyzer reuse has a differential impact on outcomes with HF vs low flyx (LF dialyzers.Proportional Hazards Models and Joint Models for longitudinal measures and survival outcomes were used in HEMO to analyze the relationship between β2-microglobulin (β2M concentration, flux, and reuse. Meta-analysis and regression techniques were used to synthesize the evidence for HF dialysis from HEMO and MPO.In HEMO, minimally reused (< 6 times HF dialyzers were associated with a hazard ratio (HR of 0.67 (95% confidence interval, 95%CI: 0.48-0.92, p = 0.015, 0.64 (95%CI: 0.44 - 0.95, p = 0.03, 0.61 (95%CI: 0.41 - 0.90, p = 0.012, 0.53 (95%CI: 0.28 - 1.02, p = 0.057 relative to minimally reused LF ones for all cause, cardiovascular, cardiac and infectious mortality respectively. These relationships reversed for extensively reused membranes (p for interaction between reuse and flux < 0.001, p = 0.005 for death from all cause and cardiovascular causes, while similar trends were noted for cardiac and infectious mortality (p of interaction between reuse and flux of 0.10 and 0.08 respectively. Reduction of β2M explained only 1/3 of the effect of minimally reused HF dialyzers on all cause mortality, while non-β2M related factors explained the apparent attenuation of the benefit with more extensively reused dialyzers. Meta-regression of HEMO and MPO estimated an adjusted HR of 0.63 (95% CI: 0.51-0.78 for non-reused HF dialyzers compared with non-reused LF membranes.This secondary analysis and synthesis of two large hemodialysis trials supports the widespread use of HF dialyzers in clinical hemodialysis over the last decade. A mechanistic understanding of the effects of

  9. Dialyzer reuse following manual reprocessing with a new sterilant, RenNew-D.

    Science.gov (United States)

    Gagnon, R; Adkar, V; Kaye, M

    1987-04-01

    Dialysis patients are at risk for toxicity from formaldehyde used in the reprocessing of dialyzers for reuse; therefore, replacing formaldehyde as a dialyzer sterilant would be advantageous. The potential for RenNew-D as a sterilizing agent was investigated in seven stable in-center hemodialysis patients over 20 consecutive dialyses with cuprammonium cellulose hollow-fiber dialyzers. Treatment with RenNew-D showed no toxicity to patients or dialyzers except for two blood leaks occurring in one patient. The mean number of dialyzer uses was 4.9. In all the dialyzers that passed functional testing small solute clearances were maintained with reuse. The ability of RenNew-D to improve the biocompatibility of reused dialyzers was documented with mean neutrophil counts falling to only 78% of initial values during first reuse of dialyzers processed with RenNew-D compared with a decrease in neutrophil count to 2% of initial values during first use of the same dialyzers. Our results suggest that RenNew-D may be a useful alternative to formaldehyde for the purpose of dialyzer reuse. A reuse procedure that includes processing with RenNew-D is associated with improved biocompatibility, possibly because of maintenance of the blood-derived membrane coating established during prior dialysis.

  10. Urea and ammonia excretion into gastric juice in regularly dialyzed patients and patients after renal transplantation. I. Dialyzed patients.

    Science.gov (United States)

    Skála, I; Marecková, O; Růzicková, J; Bláha, J; Straková, M; Reneltová, I; Jirka, J; Kocandrle, V; Zvolánková, K

    1978-01-01

    In regularly dialyzed patients in basal gastric juice and after stimulation with pentagastrin the volume of titrable acidity, urea and ammonia were assessed. It was revealed that in relation to the plasma urea concentration in basal juice the mean urea and ammonia concentration is roughly half and in stimulation juice roughly one third. The urea concentration in gastric juice is negatively correlated to the ammonia concentration. Urea excretion into the stomach depends on the plasma urea level and on the secretory gastric activity. The decisive factor of gastric secretion is probably parietal cell secretion. From the results ensues that gastric juice of dialyzed patients contains a quantitatively significant amount of urea and ammonia. Ammonia due to its neutralizing action distorts the examination of gastric acidity assessed by titration. The findings call for a revision of hitherto known data concerning gastric secretion of uraemic patients.

  11. Construction of a Liposome Dialyzer for preparation of high-value, small-volume liposome formulations

    OpenAIRE

    Adamala, Katarzyna; Engelhart, Aaron E.; Kamat, Neha P.; Jin, Lin; Szostak, Jack W.

    2015-01-01

    The liposome dialyzer is a small-volume equilibrium dialysis device, built from commercially available materials, that is designed for rapid exchange of small volumes of an extraliposomal reagent pool against a liposome preparation. The dialyzer is prepared by modification of commercially available dialysis cartridges and consists of a reactor with two 300 µL chambers and a 1.56 cm2 dialysis surface area. The dialyzer is prepared in three stages: 1) disassembly of dialysis cartridges to obtai...

  12. Comparative crossover controlled study using poly sulphone and Vitamin E coated dialyzers

    International Nuclear Information System (INIS)

    Al-Jonderby, Mohammad S.; Cabaguing, IoIani; Pajarillo, Amillata A.

    2003-01-01

    There is relatively little clinical experience reported on the use of vitamin E coated dialyzer (CL-EE 12, Terumo). This study compares its efficacy and intradialytic symptoms with a poly sulphone dialyzer in 2 group of patients in a controlled crossover trial design. This study was carried out at at Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia, during time period from January to March 2002. In group A, 34 patients were dialyzed for 4 weeks with vitamin E dialyzer and then switched over to Fresenius 60 ( F60)for 4 weeks .In group B, 41 patients were dialyzed with F60 for 4 weeks then switched over to vitamin E coated dialyzers for 4 weeks .The following parameters were measured weekly ,hemoglobin level ,urea reduction ratio (URR), urea clarence ratio (Kt/V), pre and post dialysis diastolic blood pressure (DBP)and diastolic blood pressure (DBP), interdialytic weight gain. The patients were observed for interdialytic hypertension or symptoms.No significant findings were found in any of the parameters except more dialyzer clotting was observed with vitamin E dialyzer than in F60 dialyzers(1.6%of dialysis sessions versus 0.1% P<0.03).The interdialytic weight gain tended to be less in vitamin E group but did not reach statistically significant difference.The Kt / V and URR were slightly higher when using vitamin E dialyzer only in the second and third weeks hypotensive episodes( P<,007)less leg cramp (P<.31) and less itching (P<,0.2) in the vitamin E coated treated group within group. There were only minor differences noted between between the 2 dialyzers in the parameters measured. (author)

  13. Dialyzer Reuse with Peracetic Acid Does Not Impact Patient Mortality

    Science.gov (United States)

    Bond, T. Christopher; Krishnan, Mahesh; Wilson, Steven M.; Mayne, Tracy

    2011-01-01

    Summary Background and objectives Numerous studies have shown the overall benefits of dialysis filter reuse, including superior biocompatibility and decreased nonbiodegradable medical waste generation, without increased risk of mortality. A recent study reported that dialyzer reprocessing was associated with decreased patient survival; however, it did not control for sources of potential confounding. We sought to determine the effect of dialyzer reprocessing with peracetic acid on patient mortality using contemporary outcomes data and rigorous analytical techniques. Design, setting, participants, & measurements We conducted a series of analyses of hemodialysis patients examining the effects of reuse on mortality using three techniques to control for potential confounding: instrumental variables, propensity-score matching, and time-dependent survival analysis. Results In the instrumental variables analysis, patients at high reuse centers had 16.2 versus 15.9 deaths/100 patient-years in nonreuse centers. In the propensity-score matched analysis, patients with reuse had a lower death rate per 100 patient-years than those without reuse (15.2 versus 15.5). The risk ratios for the time-dependent survival analyses were 0.993 (per percent of sessions with reuse) and 0.995 (per unit of last reuse), respectively. Over the study period, 13.8 million dialyzers were saved, representing 10,000 metric tons of medical waste. Conclusions Despite the large sample size, powered to detect miniscule effects, neither the instrumental variables nor propensity-matched analyses were statistically significant. The time-dependent survival analysis showed a protective effect of reuse. These data are consistent with the preponderance of evidence showing reuse limits medical waste generation without negatively affecting clinical outcomes. PMID:21566107

  14. Do clinical outcomes in chronic hemodialysis depend on the choice of a dialyzer?

    Science.gov (United States)

    Ward, Richard A

    2011-01-01

    Nephrologists are presented with a range of choices when selecting a dialyzer for chronic hemodialysis. Dialyzers differ in the material, structure, permeability and surface area of their membrane, and how the dialyzer is sterilized. Opinions vary regarding the impact of dialyzer characteristics on patient outcomes and which, if any, of these properties to take into account when choosing a dialyzer can be confusing. In the general dialysis population, there is no compelling evidence that the choice of a membrane material from among those materials currently in clinical use has a significant impact on morbidity or mortality (although there are rare patients who will react adversely to a given dialysis membrane). Similarly, most dialyzers are capable of adequately removing small solutes, such as urea, provided they are used with an appropriate blood flow rate and treatment time to ensure delivery of a single-pool Kt/V(urea) of at least 1.25 for men and 1.65 for women. However, in some dialysis patient subpopulations, the results of randomized clinical trials suggest that use of dialyzer containing high-flux membranes confers an outcome advantage. The extent to which this advantage is realized might also depend on how the dialyzer is used, with application in convective therapies such as hemodiafiltration being superior to diffusive therapies such as hemodialysis. This possibility is currently the subject of several large clinical trials. © 2011 Wiley Periodicals, Inc.

  15. Determination of blood loss during dialysis with capillary and plate dialyzers using 111 In-labelled erythrocytes

    International Nuclear Information System (INIS)

    Sinn, H.; Schueler, H.W.; Horsch, R.; Ostertag, H.; Clorius, J.; Moehring, K.

    1976-01-01

    Two types of Hollow Fiber Artificial Kidneys and four different types of plate-dialyzers were investigated with 111-In-labelled red-cells, to quantify the bloodloss during dialyzation. The different dialyzers showed significant differences in this respect. Two models were found to be superior, since they regularly caused only a minimal bloodloss

  16. Cooking Chicken Breast Reduces Dialyzable Iron Resulting from Digestion of Muscle Proteins

    Directory of Open Access Journals (Sweden)

    Aditya S. Gokhale

    2014-01-01

    Full Text Available The purpose of this research was to study the effect of cooking chicken breast on the production of dialyzable iron (an in vitro indicator of bioavailable iron from added ferric iron. Chicken breast muscle was cooked by boiling, baking, sautéing, or deep-frying. Cooked samples were mixed with ferric iron and either extracted with acid or digested with pepsin and pancreatin. Total and ferrous dialyzable iron was measured after extraction or digestion and compared to raw chicken samples. For uncooked samples, dialyzable iron was significantly enhanced after both extraction and digestion. All cooking methods led to markedly reduced levels of dialyzable iron both by extraction and digestion. In most cooked, digested samples dialyzable iron was no greater than the iron-only (no sample control. Cooked samples showed lower levels of histidine and sulfhydryls but protein digestibility was not reduced, except for the sautéed sample. The results showed that, after cooking, little if any dialyzable iron results from digestion of muscle proteins. Our research indicates that, in cooked chicken, residual acid-extractable components are the most important source of dialyzable iron.

  17. Cooking Chicken Breast Reduces Dialyzable Iron Resulting from Digestion of Muscle Proteins.

    Science.gov (United States)

    Gokhale, Aditya S; Mahoney, Raymond R

    2014-01-01

    The purpose of this research was to study the effect of cooking chicken breast on the production of dialyzable iron (an in vitro indicator of bioavailable iron) from added ferric iron. Chicken breast muscle was cooked by boiling, baking, sautéing, or deep-frying. Cooked samples were mixed with ferric iron and either extracted with acid or digested with pepsin and pancreatin. Total and ferrous dialyzable iron was measured after extraction or digestion and compared to raw chicken samples. For uncooked samples, dialyzable iron was significantly enhanced after both extraction and digestion. All cooking methods led to markedly reduced levels of dialyzable iron both by extraction and digestion. In most cooked, digested samples dialyzable iron was no greater than the iron-only (no sample) control. Cooked samples showed lower levels of histidine and sulfhydryls but protein digestibility was not reduced, except for the sautéed sample. The results showed that, after cooking, little if any dialyzable iron results from digestion of muscle proteins. Our research indicates that, in cooked chicken, residual acid-extractable components are the most important source of dialyzable iron.

  18. Polyphenol bioavailability in nuts and seeds by an in vitro dialyzability approach.

    Science.gov (United States)

    Herbello-Hermelo, Paloma; Lamas, Juan Pablo; Lores, Marta; Domínguez-González, Raquel; Bermejo-Barrera, Pilar; Moreda-Piñeiro, Antonio

    2018-07-15

    An in vitro dialyzability approach has been undertaken to elucidate the bioavailable fraction of the total polyphenols (TPs) of edible nuts and seeds. The TP contents in samples and in dialyzates were assessed by the Folin-Ciocalteu spectrophotometric method. Antioxidant activity was determined in selected samples, using a modified method against Trolox®. TPs and antioxidant activity in nuts/seeds were determined after applying a pressurized liquid extraction sample pre-treatment. High dialyzability ratios were assessed in most nuts/seeds (TP dialyzability percentages within the 25-91% range). The highest TP dialyzability ratios were found in raw Brazil nuts (81 ± 5%), toasted pistachios (88 ± 9%), and fried cashews (89 ± 9%), whereas TPs in pumpkin seeds were found to be very low (TPs were not detected in the dialyzable fraction). TP dialyzability was correlated with the copper content in nuts and seeds. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Effect of RenNew-D as a sterilant on the performance of reused dialyzers.

    Science.gov (United States)

    Gagnon, R F; Adkar, V; Kaye, M

    1986-12-01

    RenNew-D (Alcide), a novel demand-release sporocidal agent, was employed instead of formaldehyde in the reprocessing for reuse of cuprophan hollow fiber dialyzers (Gambro) and the performance of these dialyzers was evaluated over 40 consecutive dialyses in six patients on maintenance hemodialysis. When RenNew-D was part of automated reprocessing performed with 4.3% bleach as specified by the manufacturer (Lixivitron), dialyzer survival was prolonged (16.7 +/- 7.2 uses) and hemodialysis neutropenia was unchanged with reuse. When RenNew-D was part of manual reprocessing conducted in the absence of bleach, marked improvement in dialyzer biocompatibility was observed but with a decreased survival (4.8 +/- 3.0). The majority of dialyzer failures were due to a fall in fiber bundle volume below a 85% set limit. Small solute clearances were maintained with both types of reprocessing. Dialyses were well tolerated throughout. Our data suggest that RenNew-D is a safe and efficacious product which can serve as a valuable alternative to formaldehyde for the purpose of dialyzer reuse.

  20. Effect of vitamin E-bonded dialyzer on eosinophilia in haemodialysis patients.

    Science.gov (United States)

    Kojima, Kenichiro; Oda, Kuniyoshi; Homma, Hitoshi; Takahashi, Kazushi; Kanda, Yoshiko; Inokami, Taketoshi; Uchida, Shunya

    2005-09-01

    Eosinophilia in haemodialysis patients probably results from allergy to haemodialysis-related materials, including dialyzer membranes. We examined the effects of vitamin E-bonded dialyzers on eosinophil counts in haemodialysis patients. We enrolled seven patients who were on regular haemodialysis and had sustained eosinophilia. White blood cell, eosinophil, CD4- and CD8-positive lymphocyte counts, and serum interleukin-5 (IL-5) and IgE levels were determined before, 2 and 4 weeks after switching to vitamin E-bonded dialyzers. Eosinophil and CD4-positive lymphocyte counts and serum IL-5 were significantly (P = 0.003, 0.003 and 0.031, respectively) decreased after switching to vitamin E-bonded dialyzers. CD8-positive lymphocyte counts and serum IgE levels were unaltered. Crossover tests in two cases reproduced the higher eosinophilia within 4 weeks after returning to the original non-vitamin E-bonded dialyzer. Vitamin E-bonded dialyzers may ameliorate eosinophilia through a mechanism mediated by a decrease in IL-5 secretion by CD4-positive lymphocytes.

  1. Construction of a Liposome Dialyzer for preparation of high-value, small-volume liposome formulations

    Science.gov (United States)

    Adamala, Katarzyna; Engelhart, Aaron E.; Kamat, Neha P.; Jin, Lin; Szostak, Jack W.

    2016-01-01

    The liposome dialyzer is a small-volume equilibrium dialysis device, built from commercially available materials, that is designed for rapid exchange of small volumes of an extraliposomal reagent pool against a liposome preparation. The dialyzer is prepared by modification of commercially available dialysis cartridges and consists of a reactor with two 300 µL chambers and a 1.56 cm2 dialysis surface area. The dialyzer is prepared in three stages: 1) disassembly of dialysis cartridges to obtain required parts; 2) assembly of the dialyzer; and 3) sealing the dialyzer with epoxy. Preparation of the dialyser takes about 1.5 h, not including overnight epoxy curing. Each round of dialysis takes 1–24 h, depending on the analyte and membrane employed. We previously used the dialyzer for small-volume nonenzymatic RNA synthesis reactions inside fatty acid vesicles. In this protocol, we demonstrate other applications, including removal of unencapsulated calcein from vesicles, remote loading, and vesicle microscopy. PMID:26020615

  2. Histopathology of murine toxoplasmosis under treatment with dialyzable leukocyte extract

    Directory of Open Access Journals (Sweden)

    Beatriz Eugenia Fuentes-Castro

    Full Text Available BACKGROUND Dialyzable leukocyte extracts (DLEs contain molecules smaller than 10 kDa with biological activity in receptor organisms. Primarily, they participate in the regulation of the Th1 immune response, which is essential for the control of several intracellular infections, such as toxoplasmosis. This disease is associated with congenital infection, encephalitis or systemic infections in immunocompromised individuals. The clinical course of this infection fundamentally depends on a well-regulated immune response and timely treatment with the appropriate drugs. OBJECTIVE The aim of this study was to evaluate the effect of treatment with a leukocyte extract, derived from crocodile lymphoid tissue, on the histopathology and brain parasite load in NIH mice that had been infected with cysts of Toxoplasma gondii (ME-49 strain. METHODS The treatment was applied during the acute and chronic stages of the infection. Histopathological changes were evaluated in the ileum, liver and spleen at one, four and eight weeks after infection and in the brain at week 8. The parasite load was evaluated by counting the cysts of T. gondii found in the brain. FINDINGS Compared to the control mouse group, the mice infected with T. gondii and under treatment with DLE showed less tissue damage, mainly at the intestinal, splenic and hepatic levels. In addition, a greater percentage of survival was observed, and there was a considerable reduction in the parasite load in the brain. CONCLUSIONS The results suggest that DLE derived from crocodile is a potential adjunctive therapy in the conventional treatment of toxoplasmosis.

  3. Bioimpacts of dialyzer variety on phosphorus level in Iranian hemodialysis patients

    Science.gov (United States)

    Pezeshgi, Aiyoub; Moharrami, Bahareh; Kolifarhood, Goodarz; Sadeghi, Alireza; Asadi-Khiavi, Masoud

    2016-01-01

    Introduction: Cardiovascular events are the major cause of death in patients with chronic renal failure. About half of dialysis patients because of reduced phosphorus clearance have hyperphosphatemia. Hyperphosphatemia and following secondary hyperparathyroidism lead to some cardiovascular changes. Hemodialysis (HD) partly removes phosphorus during each dialysis session. Objectives: Presented study was designed to evaluate dialyzer variation effect on phosphorus level as a prognostic factor after dialysis using. Materials and Methods: Six kinds of dialyzer were used for dialysis; low flux (LF) dialyzer (F7 and F8), high flux (HF) dialyzer (F70 and F80) and finally hollow-fiber dialyzers including polyethersulfone (PES) 130 HF and polysulfone (PS) 13 LF. Fifty-seven patients were divided into 6 matched groups included three groups of 10 people and 3 groups of 9 persons in groups: A (F70), B (F80), C (F7), D (F8), E (PES 130 HF) and F (PS 13 LF). Patients were treated for one month with these dialyzers. At the end of the month, blood samples were taken again for phosphorus level before dialysis handling. Results: The mean pre-dialysis serum phosphorus was 5.03, 5.4, 5.2, 4.6, 4.95 and 5.1 mg/dl and the mean phosphorus was 5.43, 5.01, 4.9, 4.18, 4.17 and 5.3 mg/dl after one month of dialysis, respectively in groups A to F without any statistically differences between pre- and after one month dialysis values respectively. Discussion: The findings indicate dialyzer type in the control of serum phosphorus has not been effective in the short-term HD. We suggest a study with more duration time. PMID:27471742

  4. Discussion of conditions for antisepsis of hollow fiber-type blood dialyzer with radiation

    International Nuclear Information System (INIS)

    Morita, Makoto; Ogawa, Tadayuki; Ichikura, Shigeru

    1978-01-01

    A load index bacteria for this dialyzer was B. pumilus E 601 spore, and the number of surviving bacteria was counted after irradiation of gamma-ray with fixed doses. At the same time, D value of irradiation dose was estimated from the maximum and the minimum doses within a dialyzer which were measured actually. There were differences of 20 to 40% and 10% between dose in the center and that in both sides of a dialyzer and between that in the top and that in the bottom of a dialyzer, respectively. Accordingly, it was suspected that survival rate of bacteria changed according to parts of a dialyzer. Survival curve showed two phase such as a low dose phase and a high dose phase from actually measured values. When the number of survival bacteria was obtained as the mean value in the whole apparatus, D value was calculated from survival curve drawn on the basis of the mean value of the maximum dose, and antisepsis dose was calculated by this D value. As the calculation of antisepsis dose used D value in a high dose, phase antisepsis dose was not lower than that calculated on the basis of real D value. (Tsunoda, M.)

  5. The cell engineering construction and function evaluation of multi-layer biochip dialyzer.

    Science.gov (United States)

    Zhu, Wen; Li, Jiwei; Liu, Jianfeng

    2013-10-01

    We report the fabrication and function evaluation of multi-layer biochip dialyzer. Such device may potentially be applied to the wearable hemodialysis systems. By merging the advantages of microfluidic chip technology with cell engineering, both functions of glomerular filtration and renal tubule physiological activity are integrated in the same device. This device is designed into a laminated structure, in which the chip number of the superimposed layer can be arbitrarily tailored in accordance with the requirements of dialysis capacity. We propose that such structure can overcome the obstacles of large size and detached structure of the traditional hollow fiber dialyzer. To construct this multilayer biochips dialyzer, two types of dialyzer device with two-layered and six-layered chips are assembled, respectively. Cell adhesion and proliferation on three different dialysis membrane materials under static and dynamic conditions are investigated and compared. The filtration capability, re-absorption function and excrete ammonia function of the resulting multi-layer biochip dialyzer are evaluated. The results reveal that the constructed device can perform higher filtration efficiency and also play a role of renal tubule. This methodology may be useful in developing "scaling down" artificial kidneys that can act as wearable or even implantable hemodialysis systems.

  6. Process for treating the dialyzed spent liquor from sulphonic acid containing sulfur minerals or tar oils or ammonium salts

    Energy Technology Data Exchange (ETDEWEB)

    Wernicke, E A

    1936-08-09

    Process for working up the dialyzate from sulfonic acid, sulfur-containing mineral or tar oils, or their ammonium salts, characterized by the combination of known steps, in the dialyzate being reacted with alkaline-earth oxide, hydroxide, or carbonate, and the resulting slightly soluble sulfate being filtered off and evaporated if necessary.

  7. Cooking Chicken Breast Reduces Dialyzable Iron Resulting from Digestion of Muscle Proteins

    OpenAIRE

    Gokhale, Aditya S.; Mahoney, Raymond R.

    2014-01-01

    The purpose of this research was to study the effect of cooking chicken breast on the production of dialyzable iron (an in vitro indicator of bioavailable iron) from added ferric iron. Chicken breast muscle was cooked by boiling, baking, sautéing, or deep-frying. Cooked samples were mixed with ferric iron and either extracted with acid or digested with pepsin and pancreatin. Total and ferrous dialyzable iron was measured after extraction or digestion and compared to raw chicken samples. For u...

  8. Effects of citrate-enriched bicarbonate based dialysate on anticoagulation and dialyzer reuse in maintenance hemodialysis patients.

    Science.gov (United States)

    Rocha, Amanda D; Padua, Vanessa C; Oliveira, Esther; Guimaraes, Márcia M; Lugon, Jocemir R; Strogoff de Matos, Jorge P

    2014-04-01

    Systemic anticoagulation with unfractionated heparin is commonly used in maintenance hemodialysis (HD), but it increases the risk of bleeding complications. We investigated whether the use of citrate-enriched bicarbonate based dialysate (CD) would reduce systemic anticoagulation without compromising the efficacy of reprocessed dialyzers. This is a crossover study in which half of a total of 30 patients initially underwent HD with acetate-enriched bicarbonate based dialysate and a standard heparin dose of ∼ 100 IU/kg (Treatment A), whereas the remaining patients were treated with CD and a 30% reduced heparin dose (Treatment B). After 12 consecutive HD sessions in each treatment, the dialysate and heparin doses were reversed, then followed for another period of 12 HD sessions. The two treatment phases were split by a washout period of six HD sessions using acetate-enriched bicarbonate based dialysate and standard heparin dose. Systemic anticoagulation was higher in Treatment A. The activated partial thromboplastin time at the end of HD session was 68 ± 36 seconds in Treatment A and 47 ± 16 seconds in Treatment B (P = 0.005). Sixty-eight percent of the dialyzers remained adequate until the 12th use in Treatment A and 61% did so in Treatment B (P = 0.63). Patients had three and 24 cramps episodes during Treatment A and B, respectively (P < 0.001). Nine and 26 symptomatic intradialytic hypotension episodes were seen in Treatment A and B, respectively, (P = 0.003). In conclusion, the use of CD had a favorable effect on anticoagulation in the extracorporeal circuit in patients on maintenance HD, but it was also associated with more hypotension and cramps. © 2013 International Society for Hemodialysis.

  9. Health Differences between Roma and Non-Roma in the Slovak Dialyzed Population

    Directory of Open Access Journals (Sweden)

    Gabriel Kolvek

    2018-02-01

    Full Text Available Background: Roma health has not been studied systematically. Thus far, it has been shown that Roma compared to non-Roma have a significantly higher likelihood of getting end-stage renal disease and that their chances for survival on dialysis are lower. Evidence is lacking regarding morbidity between Roma and non-Roma. The aim was to compare the health status of dialyzed Roma and non-Roma using the Charlson comorbidity index (CCI. All Slovak dialysis centers for adults were asked to fill in a questionaire with demographic and clinical data, including comorbidity. Cross-sectional analysis of 2082 patients with an average age of 63.8 ± 13.8 years was performed. Comorbidity was expressed as the CCI, and ethnic differences were calculated. Linear regression was performed to adjust for differences in gender and age in both ethnic groups. Roma represented 13.0% of the whole dialyzed population (n = 270. Comorbidity expressed as CCI was significantly lower in the Roma population (p < 0.001. After adjusting for gender and age, ethnicity failed to be associated with the CCI in the linear regression analysis (p = 0.965, variance of the model—adjusted R2 38.6%. The health status of dialyzed Slovak Roma does not differ cross-sectionally when adjusted for age and gender from the health status of dialyzed non-Roma.

  10. Bioimpacts of dialyzer variety on phosphorus level in Iranian hemodialysis patients

    OpenAIRE

    Pezeshgi, Aiyoub; Moharrami, Bahareh; Kolifarhood, Goodarz; Sadeghi, Alireza; Asadi-Khiavi, Masoud

    2016-01-01

    Introduction: Cardiovascular events are the major cause of death in patients with chronic renal failure. About half of dialysis patients because of reduced phosphorus clearance have hyperphosphatemia. Hyperphosphatemia and following secondary hyperparathyroidism lead to some cardiovascular changes. Hemodialysis (HD) partly removes phosphorus during each dialysis session. Objectives: Presented study was designed to evaluate dialyzer variation effect on phosphorus level as a prognostic factor a...

  11. Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations.

    Science.gov (United States)

    Adamala, Katarzyna; Engelhart, Aaron E; Kamat, Neha P; Jin, Lin; Szostak, Jack W

    2015-06-01

    The liposome dialyzer is a small-volume equilibrium dialysis device, built from commercially available materials, that is designed for the rapid exchange of small volumes of an extraliposomal reagent pool against a liposome preparation. The dialyzer is prepared by modification of commercially available dialysis cartridges (Slide-A-Lyzer cassettes), and it consists of a reactor with two 300-μl chambers and a 1.56-cm(2) dialysis surface area. The dialyzer is prepared in three stages: (i) disassembling the dialysis cartridges to obtain the required parts, (ii) assembling the dialyzer and (iii) sealing the dialyzer with epoxy. Preparation of the dialyzer takes ∼1.5 h, not including overnight epoxy curing. Each round of dialysis takes 1-24 h, depending on the analyte and membrane used. We previously used the dialyzer for small-volume non-enzymatic RNA synthesis reactions inside fatty acid vesicles. In this protocol, we demonstrate other applications, including removal of unencapsulated calcein from vesicles, remote loading and vesicle microscopy.

  12. Exposure to potentially toxic hydrocarbons and halocarbons released from the dialyzer and tubing set during hemodialysis.

    Science.gov (United States)

    Lee, Hyun Ji Julie; Meinardi, Simone; Pahl, Madeleine V; Vaziri, Nostratola D; Blake, Donald R

    2012-10-01

    Although much is known about the effect of chronic kidney failure and dialysis on the composition of solutes in plasma, little is known about their impact on the composition of gaseous compounds in exhaled breath. This study was designed to explore the effect of uremia and the hemodialysis (HD) procedure on the composition of exhaled breath. Breath samples were collected from 10 dialysis patients immediately before, during, and after a dialysis session. To determine the potential introduction of gaseous compounds from dialysis components, gasses emitted from dialyzers, tubing set, dialysate, and water supplies were collected. Prospective cohort study. 10 HD patients and 10 age-matched healthy individuals. Predictors include the dialyzers, tubing set, dialysate, and water supplies before, during, and after dialysis. Changes in the composition of exhaled breath. A 5-column/detector gas chromatography system was used to measure hydrocarbon, halocarbon, oxygenate, and alkyl nitrate compounds. Concentrations of 14 hydrocarbons and halocarbons in patients' breath rapidly increased after the onset of the HD treatment. All 14 compounds and 5 others not found in patients' breath were emitted from the dialyzers and tubing sets. Contrary to earlier reports, exhaled breath ethane concentrations in our dialysis patients were virtually unchanged during the HD treatment. Single-center study with a small sample size may limit the generalizability of the findings. The study documented the release of several potentially toxic hydrocarbons and halocarbons to patients from the dialyzer and tubing sets during the HD procedure. Because long-term exposure to these compounds may contribute to the morbidity and mortality in dialysis population, this issue should be considered in the manufacturing of the new generation of dialyzers and dialysis tubing sets. Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  13. Inflammatory response of a new synthetic dialyzer membrane. A randomised cross-over comparison between polysulfone and helixone.

    Science.gov (United States)

    Stefoni, S; Colì, L; Cianciolo, G; Donati, G; Ruggeri, G; Ramazzotti, E; Pohlmeier, R; Lang, D

    2003-01-01

    Hemodialysis patients suffer from chronic inflammation due to intradialytic contact of blood with artificial materials. The FX 60 dialyzer which belongs to the new FX-class series of dialyzers is composed of the new membrane Helixone. This membrane is derived from the original Fresenius Polysulfone membrane. The FX-class design is based on modified geometry of fibres and housing and has resulted in a new dialyzer with improved efficiency, safety and ease of handling compared to the F series (F 60S) dialyzer. The aim of the study was to investigate whether the biocompatibility pattern in terms of inflammatory parameters of the new type of polysulfone dialyzer has changed compared to the standard. A clinical in vivo study was conducted to compare the intradialytic inflammatory response of the two dialyzers, FX 60 and F 60S. Eight chronic dialysis patients were selected for the study: mean age 65.5 +/- 15.5 years, mean time on dialysis 100 +/- 95 months. The randomized cross-over study involved a treatment period of 2 weeks (total 6 sessions), one week with each dialyzer, starting with one or the other according to the randomization scheme. Blood samples were taken at 0 (T0), 15, 60, and 240 minutes to evaluate white blood cell (WBC) count, complement factor C5a, leukocyte elastase, soluble intercellular adhesion molecule 1 (sICAM-1), platelet count, C-reactive protein (CRP). At 15 min, WBC count showed a comparably, low decrease for both dialyzers: -7.6% for FX 60 versus -6.6% for F 60S, p=not significant (ns). At the same time the C5a concentration decreased from 15.0 +/- 7.5 ng/ml to 13.5 +/- 6.7 ng/ml (p=ns) for FX 60, and from 15.1 +/- 12.5 ng/ml to 14.9 +/- 25.0 ng/ml for F 60S (p=ns). The elastase concentration progressively increased over time with no statistical difference between the two dialyzers. The levels of sICAM-1, CRP, and platelet count were similar at each time point for both dialyzers, varying around the baseline values (p=ns). No significant

  14. Surface characterization of dialyzer polymer membranes by imaging ToF-SIMS and quantitative XPS line scans.

    Science.gov (United States)

    Holzweber, Markus; Lippitz, Andreas; Krueger, Katharina; Jankowski, Joachim; Unger, Wolfgang E S

    2015-03-24

    The surfaces of polymeric dialyzer membranes consisting of polysulfone and polyvinylpyrrolidone were investigated regarding the lateral distribution and quantitative surface composition using time-of-flight secondary-ion-mass-spectrometry and x-ray photoelectron spectroscopy. Knowledge of the distribution and composition on the outer surface region is of utmost importance for understanding the biocompatibility of such dialyzer membranes. Both flat membranes and hollow fiber membranes were studied.

  15. Hemodialysis-associated neutropenia and hypoxemia: the effect of dialyzer membrane materials.

    Science.gov (United States)

    Hakim, R M; Lowrie, E G

    1982-01-01

    The fall in white blood cells (WBC) and arterial oxygen pressure that occurs during hemodialysis was investigated as a function of different dialysis membranes and different sterilization methods. 8 chronic hemodialysis patients were studied and each was dialyzed with three different membranes: cellulosic hollow fiber, polyacrylonitrile flat sheet and polymethylmethacrylate hollow fiber. Each dialyzer was studied with a dry sterilization method and after formalin treatment. Arterialized blood gas, bicarbonate and WBC were drawn at various intervals throughout dialysis. The effect of the sterilization method was minimal. Cellulosic membranes were shown to cause significantly more neutropenia (p less than 0.001) and hypoxemia (p less than 0.01) than the other two membranes. No significant differences was seen in pH, PCO2 and bicarbonate. The results indicate differences in biocompatibility between different membranes. Clinical implications are discussed.

  16. Scintigraphic measurements of the heart-blood-pool in dialyzed chronic uremic patients

    International Nuclear Information System (INIS)

    Nagy, E.S.; Nemessanyi, Z.; Narai, G.; Szegedi Orvostudomanyi Egyetem; Szegedi Orvostudomanyi Egyetem

    1976-01-01

    The authors have carried out scintigraphic measurements of the heart in order to diagnose the presence of an exudative pericarditis 50 times in 26 dialyzed uremic patients. Within the one year's observation 13 patients had an exudative pericarditis from the beginning on. In 8 cases a regression of the exudation could be observed. The examination has a low risk for the patient and is suitable to demonstrate clinically relevant pericardial liquid accumulation. (orig.) [de

  17. Design Concept of Dialyzer Biomaterials: How to Find Biocompatible Polymers Based on the Biointerfacial Water Structure.

    Science.gov (United States)

    Tanaka, Masaru

    2017-01-01

    Although various types of materials have been used widely in dialyzers, most biomaterials lack the desired functional properties to interface with blood and have not been engineered for optimum performance. Therefore, there is increasing demand to develop novel materials to address such problems in the dialysis arena. Numerous parameters of polymeric biomaterials can affect biocompatibility in a controlled manner. The mechanisms responsible for the biocompatibility of polymers at the molecular level have not been clearly demonstrated, although many theoretical and experimental efforts have been made to try and understand them. Moreover, water interactions have been recognized as fundamental for the blood response to contact with polymers. We have proposed the 'intermediate water' concept and hypothesized that intermediate water, which prevents the proteins and blood cells from directly contacting the polymer surface, or nonfreezing water on the polymer surface, plays an important role in the biocompatibility of polymers. This chapter provides an overview of the recent experimental progress of biocompatible polymers measured by thermal, spectroscopic, and surface force techniques. Additionally, it highlights recent developments in the use of biocompatible polymeric biomaterials for dialyzers and provides an overview of the progress made in the design of multifunctional biomedical polymers by controlling the biointerfacial water structure through precision polymer synthesis. Key Messages: Intermediate water was found only in hydrated biopolymers (proteins, polysaccharides, and nucleic acids, DNA and RNA) and hydrated biocompatible synthetic polymers. Intermediate water could be one of the main screening factors for the design of appropriate dialyzer materials. © 2017 S. Karger AG, Basel.

  18. In vitro dialyzability of essential minerals from white and whole grain pasta.

    Science.gov (United States)

    Vignola, María Belén; Bustos, Mariela Cecilia; Pérez, Gabriela Teresa

    2018-11-01

    The aim of the present investigation was to study the in vitro mineral dialyzability of pasta made with white and whole-grain flours obtained from two genotypes (Klein Guerrero and Baguette Premium 11) with different mineral contents. Pasta samples were made from white flour (FP), and whole grain flour from cyclonic mill (WFAP) and blade mill (WFBP). Mineral content and in vitro digestion were determined on all samples to study starch variation and mineral dialyzability. Whole-grain pasta contained significantly higher amounts of minerals than FP, since bran and embryo are richer in minerals than endosperm. In addition to the low content of mineral composition observed in FP, the dialyzability of some minerals (Cu, Fe, Mg and Zn) was higher than whole-grain pasta even when the percentage of starch hydrolyzed after intestinal digestion was higher than FP. These results can also be useful for developing wheat-based products rich in the desired minerals. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Influence of the dialyzer membrane material on sodium transport in hemodialysis.

    Science.gov (United States)

    Lopot, F; Kotyk, P; Bláha, J; Válek, A

    1995-11-01

    Traditionally Gibbs-Donnan coefficients based on the mean charge of plasma proteins are used as the only correction factor in equations describing sodium transport across the dialyzer membrane. This ignores the possible impact of the membrane material. Correction coefficients (CC) of the whole dialyzer were measured during in vivo dialysis as a quotient of dialysate to plasma sodium in an equilibrated state for different membrane materials used in commercially available dialyzers. Their mean value and correlation with total plasma protein content (TPP) were evaluated. CC for the six materials evaluated differed both in the intercept and slope of the regression line CC versus TPP: Cuprophan 1: CC = 1.0253 - 0.00017 x TPP; Hemophan 1: CC = 1.119 - 0.00175 x TPP; Hemophan 2: CC = 1.095 - 0.00111 x TPP; PMMA: CC = 1.0353 - 0.00044 x TPP; SCE:CC = 1.114 - 0.00145 x TPP; and Cuprophan 1:CC = 1.0562 - 0.00065 x TPP. The observed differences are attributed to the different charge densities of the membrane materials and suggest that for a precise description of sodium transport, the role of the membrane material needs to be considered.

  20. Abandoning Peracetic Acid-Based Dialyzer Reuse Is Associated with Improved Survival

    Science.gov (United States)

    Wang, Weiling; Mooney, Ann; Ofsthun, Norma; Lazarus, J. Michael; Hakim, Raymond M.

    2011-01-01

    Summary Background and objectives Higher mortality risk reported with reuse versus single use of dialyzers is potentially related to reuse reagents that modify membrane surface characteristics and the blood-membrane interface. A key mechanism may involve stimulation of an inflammatory response. Design, setting, participants, & measurements In a prospective crossover design, laboratory markers and mortality from 23 hemodialysis facilities abandoning reuse with peracetic acid mixture were tracked. C-reactive protein (CRP), white blood cell (WBC) count, albumin, and prealbumin were measured for 2 consecutive months before abandoning reuse and subsequently within 3 and 6 months on single use. Survival models were utilized to compare the 6-month period before abandoning reuse (baseline) and the 6-month period on single use of dialyzers after a 3-month “washout period.” Results Patients from baseline and single-use periods had a mean age of approximately 63 years; 44% were female, 54% were diabetic, 60% were white, and the mean vintage was approximately 3.2 years. The unadjusted hazard ratio for death was 0.70 and after case-mix adjustment was 0.74 for single use compared with reuse. Patients with CRP ≥ 5 mg/L during reuse (mean CRP = 26.6 mg/ml in April) declined on single use to 20.2 mg/L by August and 20.4 mg/L by November. WBC count declined slightly during single use, but nutritional markers were unchanged. Conclusions Abandonment of peracetic-acid-based reuse was associated with improved survival and lower levels of inflammatory but not nutritional markers. Further study is needed to evaluate a potential link between dialyzer reuse, inflammation, and mortality. PMID:20947788

  1. Nickel levels in convenience and fast foods: In vitro study of the dialyzable fraction

    International Nuclear Information System (INIS)

    Cabrera-Vique, Carmen; Mesias, Marta; Bouzas, Paula R.

    2011-01-01

    Nickel presence was determined in 170 samples of 43 different convenience and fast foods widely consumed in Spain. Electrothermal atomic absorption spectrometry was used as analytical technique. Reliability of the procedure was checked. Ni levels ranged from 18.50 to 95.00 ng g -1 (fresh weight of edible portion). The most elevated Ni concentrations were found in egg- and pork-based foods and in sauces but there is a high variability inside of each one of these foods. Ni content increases in products that contain spices and aromatic herbs, whole cereals, dry fruits, cheese and mushrooms. Mean Ni dialyzable fraction estimated by in vitro assays ranged from 4.50 to 7.75%. This study shows that the probability of exposure to health risks from these foods is overall small. However, the present findings are of potential use in food composition tables and to estimate the Ni dietary intake and tolerable intake levels in accordance with the current dietary habits. - Research highlights: →Ni levels in convenience and fast food range from 18.50 to 95.00 ng/g. →Ni content increases in products that contain spices and aromatic herbs, whole cereals, dry fruits, cheese and mushrooms. →Mean Ni dialyzable fraction estimated by in vitro assays ranges from 4.50 to 7.75%. →The probability of exposure to health risks from convenience and fast food is overall small.

  2. Nickel levels in convenience and fast foods: In vitro study of the dialyzable fraction

    Energy Technology Data Exchange (ETDEWEB)

    Cabrera-Vique, Carmen, E-mail: carmenc@ugr.es [Department of Nutrition and Bromatology, University of Granada, Granada (Spain); Mesias, Marta [Department of Nutrition and Bromatology, University of Granada, Granada (Spain); Bouzas, Paula R. [Department of Statistic, University of Granada, Granada (Spain)

    2011-03-15

    Nickel presence was determined in 170 samples of 43 different convenience and fast foods widely consumed in Spain. Electrothermal atomic absorption spectrometry was used as analytical technique. Reliability of the procedure was checked. Ni levels ranged from 18.50 to 95.00 ng g{sup -1} (fresh weight of edible portion). The most elevated Ni concentrations were found in egg- and pork-based foods and in sauces but there is a high variability inside of each one of these foods. Ni content increases in products that contain spices and aromatic herbs, whole cereals, dry fruits, cheese and mushrooms. Mean Ni dialyzable fraction estimated by in vitro assays ranged from 4.50 to 7.75%. This study shows that the probability of exposure to health risks from these foods is overall small. However, the present findings are of potential use in food composition tables and to estimate the Ni dietary intake and tolerable intake levels in accordance with the current dietary habits. - Research highlights: {yields}Ni levels in convenience and fast food range from 18.50 to 95.00 ng/g. {yields}Ni content increases in products that contain spices and aromatic herbs, whole cereals, dry fruits, cheese and mushrooms. {yields}Mean Ni dialyzable fraction estimated by in vitro assays ranges from 4.50 to 7.75%. {yields}The probability of exposure to health risks from convenience and fast food is overall small.

  3. Enhancement of the blood compatibility of dialyzer membranes by the physical adsorption of human thrombomodulin (ART-123).

    Science.gov (United States)

    Omichi, Masaaki; Matsusaki, Michiya; Kato, Shinya; Maruyama, Ikuro; Akashi, Mitsuru

    2010-11-01

    ART-123 is a recombinant soluble human thrombomodulin (hTM) with excellent anticoagulant activity. We focused on improving the blood compatibility of the polysulfone-polyvinylpyrrolidone dialyzer surface by the physical adsorption of ART-123 onto the surface. The blood compatibility of the dialyzer with the hTM adsorbed membrane was evaluated by measuring the differential pressure between the arterial and the venous pressures and by blood parameters during blood circulation. The hTM adsorbed dialyzer membrane inhibited blood clot formation without heparin administration due to the anticoagulant activity of hTM for over 4 h. The physically adsorbed hTM was stable during blood circulation, and it did not affect activated clotting time, which is significant drawback of heparin administration, and blood cell counts of RBC, WBC, or platelets. The physical adsorption of hTM onto the dialyzer membrane will be a simple and safe method to prevent blood coagulation during dialysis instead of heparin administration. © 2010 Wiley Periodicals, Inc.

  4. Pioglitazone improves insulin sensitivity, reduces visceral fat and stimulates lipolysis in non diabetic dialyzed patients

    Directory of Open Access Journals (Sweden)

    Anne Zanchi

    2012-06-01

    Full Text Available Insulin resistance is common in dialyzed patients and is associated with increased mortality and protein-energy wasting. The aim of this study was to investigate the effect of pioglitazone (PIO, a powerful insulin sensitizer, on insulin sensitivity, body composition and adipose tissue metabolism, in dialyzed patients. A double blind randomized cross-over study was performed in non diabetic dialysis patients. Each patient followed 2 treatment phases of 16 weeks, starting either with oral PIO 45 mg/d or placebo (PL, and then switched to the other phase. At the end of each phase, patients underwent hyperinsulinemic euglycemic clamps, dual energy X-ray absorptiometry, an abdominal CT, and extensive plasma biochemical analysis. Twelve patients including 8 HD (59.6±4.4 y and 4 PD patients (43.5±3.6 y were recruited. Nine patients completed both phases and 3 patients dropped out (renal transplantation/2 HD and peritonitis/1 PD. PIO was safe and well tolerated. Under PIO, insulin sensitivity improved, as assessed by increased total glucose disposal rate (1.98±0.24 for PIO versus 1.58±0.12 umol/kg/min for PL, p<0.05, and reduced glucose endogenous hepatic production. PIO did not affect post-dialysis body weight, total fat and lean body mass, but significantly reduced visceral adipose tissue (VAT area and the VAT/SAT (subcutaneous adipose tissue ratio. HDL-cholesterol significantly increased. PIO decreased CRP (3.96±1.44 mg/l vs 7.88±2.56, p<0.05, plasma leptin, and dramatically reduced leptin/adiponectin ratio. Glycerol turnover, circulating glycerol and non esterified fatty acids were paradoxically increased. In conclusion, the improvement in insulin sensitivity by PIO, in non diabetic dialyzed patients, was associated with favorable metabolic effects, reduction in inflammation and body fat redistribution. The stimulation of systemic lipolysis was a surprising finding which may reflect adipose tissue remodeling and/or a paradoxical lypolitic

  5. In vitro evaluation of iron solubility and dialyzability of various iron fortificants and of iron-fortified milk products targeted for infants and toddlers.

    Science.gov (United States)

    Kapsokefalou, Maria; Alexandropoulou, Isidora; Komaitis, Michail; Politis, Ioannis

    2005-06-01

    The objectives of the present study were: to compare the solubility and dialyzability of various iron fortificants (iron pyrophosphate, ferrous bis-glycinate, ferrous gluconate, ferrous lactate, ferrous sulfate) added, in the presence of ascorbic acid, to pasteurized milk samples produced under laboratory conditions; and to compare the solubility and dialyzability of iron in commercial pasteurized, UHT and condensed milk products available in the Greek market fortified with various vitamins and minerals including iron and targeted towards infants (6-12 months old) and toddlers. Iron solubility and dialyzability were determined using a simulated gastrointestinal digestive system. Ferrous dialyzable iron (molecular weight lower than 8000) was used as an index for prediction of iron bioavailability. Ferrous dialyzable iron in pasteurized milk samples fortified with iron pyrophosphate, ferrous lactate and ferrous bis-glycinate was higher (P iron in products fortified with ferrous lactate was not different (P > 0.05) from those fortified with ferrous sulfate. Ferrous dialyzable iron in four condensed commercial milk products was higher (P iron was higher (P iron source, milk processing and the overall product composition affect formation of ferrous dialyzable iron and may determine the success and effectiveness of iron fortification of milk.

  6. Effect of dialyzer membrane materials on survival in chronic hemodialysis patients: Results from the annual survey of the Japanese Nationwide Dialysis Registry

    OpenAIRE

    Abe, Masanori; Hamano, Takayuki; Wada, Atsushi; Nakai, Shigeru; Masakane, Ikuto

    2017-01-01

    Background Little information is available regarding which type of dialyzer membrane results in good prognosis in patients on chronic hemodialysis. Therefore, we conducted a cohort study from a nationwide registry of hemodialysis patients in Japan to establish the association between different dialyzer membranes and mortality rates. Methods We followed 142,412 patients on maintenance hemodialysis (female, 39.1%; mean age, 64.8 ? 12.3 years; median dialysis duration, 7 [4?12] years) for a year...

  7. An experimental and numerical study of the flow and mass transfer in a model of the wearable artificial kidney dialyzer

    Directory of Open Access Journals (Sweden)

    Rosenfeld Moshe

    2010-05-01

    Full Text Available Abstract Background Published studies of the past decades have established that mass transfer across the dialyzer membrane is governed by diffusion, convection and osmosis. While the former is independent of the pressure in the liquids, the latter two are pressure dependent and are enhanced when the pressure difference across the membrane is increased. The goal of the present study is to examine the impact of pulsatile flow on the transport phenomena across the membrane of a high-flux dialyzer in a wearable artificial kidney (WAK with a novel single small battery-operated pulsatile pump that drives both the blood and dialysate in a counter-phased manner, maximizing the trans-membrane pressure. Methods Both in-vitro experimental and numerical tools are employed to compare the performance of the pulsatile WAK dialyzer with a traditional design of a single-channel roller blood pump together with a centrifugal pump that drives the dialysate flow. The numerical methods utilize the axisymmetric Navier-Stokes and mass transfer equations to model the flow in the fibers of the dialyzer. Results While diffusion is still the dominating transport regime, the WAK pump enhances substantially the trans-membrane pressure and thus increases mass convection that might be as high as 30% of the overall transfer. This increase is obtained due to the design of the pulsatile WAK pump that increases ultrafiltration by increasing the trans-membrane pressure. Conclusions The experimental and numerical results revealed that when pumping at similar flow rates, a small battery-operated pulsatile pump provides clearances of urea and creatinine similar as or better than a large heavy AC-powered roller pump.

  8. Relationship of dietary factors with dialyzable iron and in vitro iron bioavailability in the meals of farm women

    OpenAIRE

    Singh, Anamika; Bains, Kiran; Kaur, Hapreet

    2016-01-01

    Sixty rural women with age varying between 25 and 35 were selected randomly to determine the role of dietary factors on bioavailability of iron in their diets. Food samples of selected subjects were collected for three major meals i.e. breakfast, lunch and dinner for three consecutive days. The samples were analyzed for meal constituents associated with iron absorption as well as for total and dialyzable iron. Based on dietary characteristics, the diets of the farm women were in the class of ...

  9. Dialyzer-augmented whole blood and plasma exchange for patients with hepatic or hepatorenal failure.

    Science.gov (United States)

    Buselmeier, T J; Merino, G E; Rodrigo, F; Meyer, R M; Bosl, B H; Kjellstrand, C M; Simmons, R L; Najarian, J S

    1975-01-01

    We have utilized new methods of dialyzer-augmented whole blood and plasma exchange tranfusion in the treatment of hepatic coma. The method employs the new fast flow Buselmeier shunt so that the exchange can be done from a peripheral radial artery shunt site rather than a shunt site in a more major vessel, such as the brachial artery. The method employs in-line dialysis of citrated (CPD) blood or plasma to normalize pH, electrolytes, and blood sugar while infusion heparinization decreases heparin requirements. The application of a single roller pump to the administration and withdrawal lines (placed in opposite directions) helps equalize inflow and outflow where whole blood exchange is done while identical opposing pumps accomplish the same with plasma exchange. The administration of albumin and metaraminol bitartate prevents hypotension due to fluid shifts or compartmental venous dilatation. A closed circuit which does not require disconnection throughout the 30- 60-minute whole blood exchange or the 2 1/2-hour plasma exchange decreases the risk of septic contamination to both medical staff and patients.

  10. Herpes Murine Model as a Biological Assay to Test Dialyzable Leukocyte Extracts Activity

    Directory of Open Access Journals (Sweden)

    Nohemí Salinas-Jazmín

    2015-01-01

    Full Text Available Human dialyzable leukocyte extracts (DLEs are heterogeneous mixtures of low-molecular-weight peptides that are released on disruption of peripheral blood leukocytes from healthy donors. DLEs improve clinical responses in infections, allergies, cancer, and immunodeficiencies. Transferon is a human DLE that has been registered as a hemoderivate by Mexican health authorities and commercialized nationally. To develop an animal model that could be used routinely as a quality control assay for Transferon, we standardized and validated a murine model of cutaneous HSV-1 infection. Using this model, we evaluated the activity of 27 Transferon batches. All batches improved the survival of HSV-1-infected mice, wherein average survival rose from 20.9% in control mice to 59.6% in Transferon-treated mice. The activity of Transferon correlated with increased serum levels of IFN-γ and reduced IL-6 and TNF-α concentrations. Our results demonstrate that (i this mouse model of cutaneous herpes can be used to examine the activity of DLEs, such as Transferon; (ii the assay can be used as a routine test for batch release; (iii Transferon is produced with high homogeneity between batches; (iv Transferon does not have direct virucidal, cytoprotective, or antireplicative effects; and (v the protective effect of Transferon in vivo correlates with changes in serum cytokines.

  11. Anti-Inflammatory Effect of Dialyzable Leukocyte Extract in Autoimmune Prostatitis: Evaluation in Animal Model

    Directory of Open Access Journals (Sweden)

    Carlos Pérez-Alvarado

    2017-01-01

    Full Text Available Objective. To evaluate the anti-inflammatory properties of Dialyzable Leukocyte Extract (DLE in a murine model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS. Methods. Histopathological characterization, prostatein Enzyme-Linked Immunosorbent Assay, and immunohistochemical analysis for CD45, TNF-α, IFN-γ, IL-6, IL-17, and IL-4 molecules were done in prostatic Wistar rats treated with DLE, placebo, or Dexamethasone. Results. Histopathological analysis of animals induced to prostatitis showed inflammatory infiltrate, mainly constituted by leucocytes and mast cells as well as Benign Prostatic Hyperplasia. Serum prostatein concentrations were 14 times higher than those displayed by healthy animals. After DLE and Dexamethasone treatments, the inflammatory infiltrate decreased; the tissue morphology was similar to that of a normal prostate, and the prostatein decreased to the basal levels of healthy animals. DLE treatment produced a decreased expression of the cell surface marker CD45 and the proinflammatory cytokines TNF-α, IFN-γ, IL-6, and IL-17. On the other hand, the expression of anti-inflammatory cytokine IL-4 increased in both the Dexamethasone and DLE groups. Conclusion. DLE is able to modulate the inflammatory response in Experimental Autoimmune Prostatitis (EAP.

  12. Influence of various forms of dialyzable leukocyte extracts on rat adjuvant arthritis

    International Nuclear Information System (INIS)

    Stancikova, Maria; Rovensky, Jozef; Blazickova, Stanislava; Pekarek, J.; Cech, Karel

    1994-01-01

    Adjuvant-induced arthritis in rats is a chronic inflammatory disease, widely as an animal model for rheumatoid arthritis. In our study the effect of various fractions of dialyzable leukocyte extract (DLE): DLE I-molecular weight below 10 kDa (commercial preparation), DLE II-molecular weight below 5 kDa (suppressor fraction), DLE III-molecular weight 5-10 kDa on rat adjuvant-induced arthritis was studied. The adjuvant arthritic (AA) rats were treated with DLE fractions i.p. in solutions containing an active substance isolated from 12.5 x 10 6 and 6.25 x 10 6 leukocytes from day 1 (adjuvant injected) through day 18, every second day (total 9 times). Various markers in inflammation, immune function and joint destruction were evaluated: hind paw volume, serum hyaluronic acid, serum albumin and biopterin in urine. All these markers showed a significant improvement after using fraction DLE II in comparison with AA controls. Fractions DLE I and DLE III influenced only some markers of inflammation and immune function. Our results demonstrated a therapeutical effect of fraction DLE II on rat adjuvant-induced arthritis. (author). 22 refs, 2 figs, 2 tabs

  13. Pharmacokinetic modeling of 4,4'-methylenedianiline released from reused polyurethane dialyzer potting materials.

    Science.gov (United States)

    Do Luu, H M; Hutter, J C

    2000-01-01

    4, 4'-Methylenedianiline (MDA) is a hydrolysis degradation product that can be released from polyurethanes commonly used in medical device applications. MDA is mutagenic and carcinogenic in animals. In humans, it is hepatotoxic, a known contact and respiratory allergen, and a suspected carcinogen. A physiologically based pharmacokinetic (PBPK) model was developed to estimate the absorption, distribution, metabolism, and excretion of MDA in patients exposed to MDA leached from the potting materials of hemodialyzers. A worst-case reuse situation and a single use case were investigated. The PBPK model included five tissue compartments: liver, kidney, gastrointestinal tract, slowly perfused tissues, and richly perfused tissues. Physiological and chemical parameters of a healthy individual used in the model were obtained from the literature. The model was calibrated using previously published kinetic studies of IV administered doses of (14) C-MDA to rats. The model was validated using independent data published for MDA-exposed workers. The PBPK results indicated that dialysis patients who are exposed to MDA released from dialyzers (new or reused) could accumulate low levels of MDA and metabolites (total MDA) over time. Copyright 2000 John Wiley & Sons, Inc.

  14. Active gate driver for dv/dt control and active voltage clamping in an IGBT stack

    DEFF Research Database (Denmark)

    Rasmussen, Tonny Wederberg

    2005-01-01

    For high voltages converters stacks of IGBTs can be used if the static and dynamic voltage sharing among the IGBTs can be applied. dVCE/dt should also be controlled in order not to damage insulation material. This paper describes theory and measurements of an active gate driver for stacking IGBTs....... For the measurements two series connected standard IGBTs made for hard switching applications are used. Problems are shown and proposals for improvements are given....

  15. A novel voltage clamp circuit for the measurement of transistor dynamic on-resistance

    NARCIS (Netherlands)

    Gelagaev, R.; Jacqmaer, P.; Everts, J.; Driesen, Johan

    2012-01-01

    For determining the dynamic on-resistance Rdyn,on of a power transistor, the voltage and current waveforms have to be measured during the switching operation. In measurements of voltage waveforms, using an oscilloscope, the characteristics of an amplifier inside the oscilloscope are distorted when

  16. Dual patch voltage clamp study of low membrane resistance astrocytes in situ.

    Science.gov (United States)

    Ma, Baofeng; Xu, Guangjin; Wang, Wei; Enyeart, John J; Zhou, Min

    2014-03-17

    Whole-cell patch clamp recording has been successfully used in identifying the voltage-dependent gating and conductance properties of ion channels in a variety of cells. However, this powerful technique is of limited value in studying low membrane resistance cells, such as astrocytes in situ, because of the inability to control or accurately measure the real amplitude of command voltages. To facilitate the study of ionic conductances of astrocytes, we have developed a dual patch recording method which permits membrane current and membrane potential to be simultaneously recorded from astrocytes in spite of their extraordinarily low membrane resistance. The utility of this technique is demonstrated by measuring the voltage-dependent activation of the inwardly rectifying K+ current abundantly expressed in astrocytes and multiple ionic events associated with astrocytic GABAA receptor activation. This protocol can be performed routinely in the study of astrocytes. This method will be valuable for identifying and characterizing the individual ion channels that orchestrate the electrical activity of low membrane resistance cells.

  17. Cell activation and cellular-cellular interactions during hemodialysis: effect of dialyzer membrane.

    Science.gov (United States)

    Sirolli, V; Ballone, E; Di Stante, S; Amoroso, L; Bonomini, M

    2002-06-01

    During hemodialysis (HD), circulating blood cells can be activated and also engage in dynamic interplay. These phenomena may be important factors behind dialysis membrane bio(in)compatibility. In the present prospective cross-over study, we have used flow cytometry to evaluate the influence of different dialysis membranes on the activation of circulating blood cells (leukocytes, platelets) and their dynamic interactions (formation of circulating platelet-leukocyte and platelet-erythrocyte aggregates) during in vivo HD. Each patient (n = 10) was treated with dialyzers containing membranes of cellulose diacetate, polysulfone and ethylenevinylalcohol (EVAL) in a randomized order. Upregulation of adhesion receptor expression (CD15s, CD11b/CD18) occurred mainly with the cellulosic membrane, though an increase in CD11b/CD18 circulating on neutrophils was also found with both synthetic membranes. Circulating activated platelets (P-selectin/CD63-positive platelets) increased during HD sessions with cellulose diacetate and polysulfone. An increased formation of platelet-neutrophil aggregates was found at 15 and 30 min during dialysis with cellulose diacetate and polysulfone but not with EVAL. Platelet-erythrocyte aggregates also increased with cellulose diacetate and at 15 min with polysulfone as well. Generally in concomitance with the increase in platelet-neutrophil coaggregates, there was an increased hydrogen peroxide production by neutrophils. The results of this study indicate that cellular mechanisms can be activated during HD largely depending on the membrane material, EVAL causing less reactivity than the other two membranes. It appears that each dialysis membrane has multiple and different characteristics that may contribute to interactions with blood components. Our results also indicate that derivatizing cellulose (cellulose diacetate) may be a useful way to improve the biocompatibility of the cellulose polymer and that there may be great variability in the

  18. Hemocompatible polyethersulfone/polyurethane composite membrane for high-performance antifouling and antithrombotic dialyzer.

    Science.gov (United States)

    Yin, Zehua; Cheng, Chong; Qin, Hui; Nie, Chuanxiong; He, Chao; Zhao, Changsheng

    2015-01-01

    Researches on blood purification membranes are fuelled by diverse clinical needs, such as hemodialysis, hemodiafiltration, hemofiltration, plasmapheresis, and plasma collection. To approach high-performance dialyzer, the integrated antifouling and antithrombotic properties are highly necessary for the design/modification of advanced artificial membranes. In this study, we propose and demonstrate that the physical blend of triblock polyurethane (PU) and polyethersulfone (PES) may advance the performance of hemodialysis membranes with greatly enhanced blood compatibility. It was found that the triblock PU could be blended with PES at high ratio owing to their excellent miscibility. The surfaces of the PES/PU composite membranes were characterized using attenuated total reflectance-Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, water contact angle measurement, and surface ζ-potentials. The results indicated that the membrane surfaces were assembled with hydrophilic segregation layer owing to the migration of amphiphilic PU segments during membrane preparation, which might confer the composite membranes with superior hemocompatibility. The cross-section scanning electron microscopy images of the composite membranes exhibited structure transformation from finger-like structure to sponge-like structure, which indicated that the composite membrane had tunable porosity and permeability. The further ultrafiltration experiments indicated that the composite membranes showed increased permeability and excellent antifouling ability. The blood compatibility observation indicated that PES/PU composite membranes owned decreased protein adsorption, suppressed platelet adhesion, and prolonged plasma recalcification time. These results indicated that the PES/PU composite membranes exhibited enhanced antifouling and antithrombotic properties than the pristine PES membrane. The strategy may forward the fabrication of blood compatible composite membranes for

  19. The effect of different dialyzer membrane on the clearance of serum β2-MG in maintenance hemodialysis patients

    International Nuclear Information System (INIS)

    Lu Yun; Xue Jun; Lin Xiangtong; Deng Shouzhen; Li Ding

    2001-01-01

    Objective: To investigate the effect of different membrane on the clearance of serum β 2 -MG in maintenance hemodialysis patients. Method: 106 maintenance hemodialysis patients randomized divided into group A and group B. Group A used cellulose triacetate membrane (N-130E), Group B used polysulfone membrane (F6). The levels of serum β 2 -MG before and after hemodialysis were compared in Group A and B, respectively. Results: Before hemodialysis, the level of serum β 2 -MG was not significant different between Group A and B (46.74 ± 19.46 mg/L vs 47.49 ± 16.71 mg/L, P>0.05). In Group A, compared with that before hemodialysis, the level of serum β 2 -MG after hemodialysis decreased significantly. (46.74±19.46 mg/L vs 39.76 ±17.66 mg/L, before HD vs after HD, P 2 -MG between before and after hemodialysis (47.49±16.71 mg/L vs 50.19±22.76 mg/L, P>0.05). Conclusion: N-130E dialyzer is better than F6 dialyzer as the effect of clearance serum β 2 -MG is concerned

  20. pO2 and pCO2 increment in post-dialyzer blood: the role of dialysate.

    Science.gov (United States)

    Sombolos, Kostas I; Bamichas, Gerasimos I; Christidou, Fotini N; Gionanlis, Lazaros D; Karagianni, Anna C; Anagnostopoulos, Theodoros C; Natse, Taïsir A

    2005-11-01

    Blood returning from a dialyzer during hemodialysis has a higher pO2 and pCO2 content than blood entering the dialyzer, and this has been attributed to the dialysate. The present study investigates this phenomenon. Acid-base and blood-gas parameters (pH, pO2, pCO2 and HCO3) were measured in three groups of stable chronic hemodialysis patients (A, B, and C) undergoing high-flux hemodialysis. In group A (n = 15), "arterial" (a) and "venous" (v) samples were withdrawn simultaneously before dialysis (samples A0), 5 min after circulation of the blood with the dialysate in the by-pass mode (samples A5), and 5 min after high-flux hemodialysis at a zero ultrafiltration rate (samples A10). In group B (n = 11) (a) and (v) samples were withdrawn simultaneously before dialysis (samples B0), 5 min after isolated-ultrafiltration with closed dialysate ports ("isolated-closed" ultrafiltration) (samples B5), and 5 min after high-flux hemodialysis at a zero ultrafiltration rate (samples B10). In group C (n = 14), after an initial arterial blood sample withdrawal before hemodialysis (sample C0), high-flux hemodialysis at a zero ultrafiltration rate was initiated. Five minutes later, blood and dialysate samples were withdrawn simultaneously from the hemodialysis lines (samples C5). In all cases blood and dialysate (bicarbonate) flow rates were set at 0.300 and 0.700 L/min, respectively. FLX-18 hemodialyzers (membrane PEPA 1.8 m2) were used in this study. Analysis of variance revealed significant changes only in venous samples. A comparison of arterial and venous samples revealed no differences between groups A and B before the initiation of dialysis (A0a vs. A0v and B0a vs. B0v, P = NS). The pO2 content was higher in A5v samples than in A5a samples (83.5 +/- 11.2 vs. 88.8 +/- 14.0 mm Hg, P pO2, pCO2, and HCO3 in comparison to A10v samples (P pO2 and pCO2 values in A5v and A10v samples increased by 6.3% and 12.1% and by 1.29% and 52% in comparison to corresponding values of A5a and A10

  1. Effect of dialyzer membrane materials on survival in chronic hemodialysis patients: Results from the annual survey of the Japanese Nationwide Dialysis Registry.

    Science.gov (United States)

    Abe, Masanori; Hamano, Takayuki; Wada, Atsushi; Nakai, Shigeru; Masakane, Ikuto

    2017-01-01

    Little information is available regarding which type of dialyzer membrane results in good prognosis in patients on chronic hemodialysis. Therefore, we conducted a cohort study from a nationwide registry of hemodialysis patients in Japan to establish the association between different dialyzer membranes and mortality rates. We followed 142,412 patients on maintenance hemodialysis (female, 39.1%; mean age, 64.8 ± 12.3 years; median dialysis duration, 7 [4-12] years) for a year from 2008 to 2009. We included patients treated with seven types of high-flux dialyzer membranes at baseline, including cellulose triacetate (CTA), ethylene vinyl alcohol (EVAL), polyacrylonitrile (PAN), polyester polymer alloy (PEPA), polyethersulfone (PES), polymethylmethacrylate (PMMA), and polysulfone (PS). Cox regression was used to estimate the association between baseline dialyzers and all-cause mortality as hazard ratios (HRs) and 95% confidence intervals for 1-year mortality adjusting for potential confounders, and propensity score matching analysis was performed. The distribution of patients treated with each membrane was as follows: PS (56.0%), CTA (17.3%), PES (12.0%), PEPA (7.5%), PMMA (4.9%), PAN (1.2%), and EVAL (1.1%). When data were adjusted using basic factors, with PS as a reference group, the mortality rate was significantly higher in all groups except for the PES group. When data were further adjusted for dialysis-related factors, HRs were significantly higher for the CTA, EVAL, and PEPA groups. When the data were further adjusted for nutrition-and inflammation-related factors, HRs were significantly lower for the PMMA and PES groups compared with the PS group. After propensity score matching, HRs were significantly lower for the PMMA group than for the PS group. The results suggest that the use of different membrane types may affect mortality in hemodialysis patients. However, further long-term prospective studies are needed to clarify these findings, including whether the

  2. In Vivo Chemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil

    Science.gov (United States)

    Coronado-Cerda, Erika Evangelina; Franco-Molina, Moisés Armides; Mendoza-Gamboa, Edgar; Prado-García, Heriberto; Rivera-Morales, Lydia Guadalupe; Zapata-Benavides, Pablo; Rodríguez-Salazar, María del Carmen; Caballero-Hernandez, Diana; Tamez-Guerra, Reyes Silvestre; Rodríguez-Padilla, Cristina

    2016-01-01

    Chemotherapy treatments induce a number of side effects, such as leukopenia neutropenia, peripheral erythropenia, and thrombocytopenia, affecting the quality of life for cancer patients. 5-Fluorouracil (5-FU) is wieldy used as myeloablative model in mice. The bovine dialyzable leukocyte extract (bDLE) or IMMUNEPOTENT CRP® (ICRP) is an immunomodulatory compound that has antioxidants and anti-inflammatory effects. In order to investigate the chemoprotection effect of ICRP on bone marrow cells in 5-FU treated mice, total bone marrow (BM) cell count, bone marrow colony forming units-granulocyte/macrophage (CFU-GM), cell cycle, immunophenotypification, ROS/superoxide and Nrf2 by flow cytometry, and histological and hematological analyses were performed. Our results demonstrated that ICRP increased BM cell count and CFU-GM number, arrested BM cells in G0/G1 phase, increased the percentage of leukocyte, granulocytic, and erythroid populations, reduced ROS/superoxide formation and Nrf2 activation, and also improved hematological levels and weight gain in 5-FU treated mice. These results suggest that ICRP has a chemoprotective effect against 5-FU in BM cells that can be used in cancer patients. PMID:27191003

  3. In Vivo Chemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil

    Directory of Open Access Journals (Sweden)

    Erika Evangelina Coronado-Cerda

    2016-01-01

    Full Text Available Chemotherapy treatments induce a number of side effects, such as leukopenia neutropenia, peripheral erythropenia, and thrombocytopenia, affecting the quality of life for cancer patients. 5-Fluorouracil (5-FU is wieldy used as myeloablative model in mice. The bovine dialyzable leukocyte extract (bDLE or IMMUNEPOTENT CRP® (ICRP is an immunomodulatory compound that has antioxidants and anti-inflammatory effects. In order to investigate the chemoprotection effect of ICRP on bone marrow cells in 5-FU treated mice, total bone marrow (BM cell count, bone marrow colony forming units-granulocyte/macrophage (CFU-GM, cell cycle, immunophenotypification, ROS/superoxide and Nrf2 by flow cytometry, and histological and hematological analyses were performed. Our results demonstrated that ICRP increased BM cell count and CFU-GM number, arrested BM cells in G0/G1 phase, increased the percentage of leukocyte, granulocytic, and erythroid populations, reduced ROS/superoxide formation and Nrf2 activation, and also improved hematological levels and weight gain in 5-FU treated mice. These results suggest that ICRP has a chemoprotective effect against 5-FU in BM cells that can be used in cancer patients.

  4. Relationship of dietary factors with dialyzable iron and in vitro iron bioavailability in the meals of farm women.

    Science.gov (United States)

    Singh, Anamika; Bains, Kiran; Kaur, Hapreet

    2016-04-01

    Sixty rural women with age varying between 25 and 35 were selected randomly to determine the role of dietary factors on bioavailability of iron in their diets. Food samples of selected subjects were collected for three major meals i.e. breakfast, lunch and dinner for three consecutive days. The samples were analyzed for meal constituents associated with iron absorption as well as for total and dialyzable iron. Based on dietary characteristics, the diets of the farm women were in the class of intermediate diets as per FAO/WHO classification with iron bioavailability of 8.11 %. The statistical analysis revealed that the meal constituents which were found to influence iron absorption positively were ascorbic acid and β-carotene in breakfast and only β-carotene in dinner. The meal constituents which affected iron absorption negatively were zinc and calcium in breakfast as well as lunch and phytates and NDF in dinner, however, polyphenols present in the meals of the subjects did not show any relationship with iron absorption.

  5. Multilayered microfilter using a nanoporous PES membrane and applicable as the dialyzer of a wearable artificial kidney

    Science.gov (United States)

    Gu, Ye; Miki, Norihisa

    2009-06-01

    We present a multilayered microfilter for use as a dialyzer of a wearable artificial kidney separating metabolic wastes such as urea, uric acid and creatinine from blood. The microfilter device is assembled by alternately bonding chamber layers made of Ti by wet etching and semipermeable polymeric membranes made of polyethersulfone (PES) by the wet phase inversion method. The PES membranes sandwiched between each two chamber layers act as barriers to molecules larger than 1.7 nm. The multilayered microfilter was geometrically optimized with respect to our theoretical equations and experimental results in order to obtain kidney-competitive performance. Each diffusing unit of our device, which is only 24 × 24 × 0.4 mm3 in size, was proved experimentally to be capable of allowing a flow rate of up to 1 ml min-1 under an input pressure of only 10 kPa, which is the hydrostatic pressure in human renal arteries, while having a urea removal rate of 18 µg min-1.

  6. Multilayered microfilter using a nanoporous PES membrane and applicable as the dialyzer of a wearable artificial kidney

    International Nuclear Information System (INIS)

    Gu, Ye; Miki, Norihisa

    2009-01-01

    We present a multilayered microfilter for use as a dialyzer of a wearable artificial kidney separating metabolic wastes such as urea, uric acid and creatinine from blood. The microfilter device is assembled by alternately bonding chamber layers made of Ti by wet etching and semipermeable polymeric membranes made of polyethersulfone (PES) by the wet phase inversion method. The PES membranes sandwiched between each two chamber layers act as barriers to molecules larger than 1.7 nm. The multilayered microfilter was geometrically optimized with respect to our theoretical equations and experimental results in order to obtain kidney-competitive performance. Each diffusing unit of our device, which is only 24 × 24 × 0.4 mm 3 in size, was proved experimentally to be capable of allowing a flow rate of up to 1 ml min −1 under an input pressure of only 10 kPa, which is the hydrostatic pressure in human renal arteries, while having a urea removal rate of 18 µg min −1

  7. Substrate and Inhibitor-Specific Conformational Changes in the Human Serotonin Transporter Revealed by Voltage-Clamp Fluorometry

    DEFF Research Database (Denmark)

    Söderhielm, Pella C; Andersen, Jacob; Munro, Lachlan

    2015-01-01

    of TM6, Ala419 in the interface between TM8 and extracellular loop (EL) 4, and Leu481 in EL5. The reporter positions were used for time-resolved measurement of conformational changes during 5-HT transport and binding of cocaine and the selective serotonin reuptake inhibitors fluoxetine and escitalopram...... changes overall, which included movements within or around TM1b, EL4, and EL5. Taken together, our data lead us to suggest that competitive inhibitors stabilize hSERT in a state that is different from the apo outward-open conformation as well as inward-facing conformations....

  8. Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal disease.

    Directory of Open Access Journals (Sweden)

    Sachin Jhawar

    as a major, poorly dialyzable, uremic toxin. The signaling pathways initiated by IS and possibly other solutes not effectively removed by dialysis may participate in the pathogenesis of renal scarring and uremic vasculopathy.

  9. Finite Volume Scheme for Double Convection-Diffusion Exchange of Solutes in Bicarbonate High-Flux Hollow-Fiber Dialyzer Therapy

    Directory of Open Access Journals (Sweden)

    Kodwo Annan

    2012-01-01

    Full Text Available The efficiency of a high-flux dialyzer in terms of buffering and toxic solute removal largely depends on the ability to use convection-diffusion mechanism inside the membrane. A two-dimensional transient convection-diffusion model coupled with acid-base correction term was developed. A finite volume technique was used to discretize the model and to numerically simulate it using MATLAB software tool. We observed that small solute concentration gradients peaked and were large enough to activate solute diffusion process in the membrane. While CO2 concentration gradients diminished from their maxima and shifted toward the end of the membrane, concentration gradients peaked at the same position. Also, CO2 concentration decreased rapidly within the first 47 minutes while optimal concentration was achieved within 30 minutes of the therapy. Abnormally high diffusion fluxes were observed near the blood-membrane interface that increased diffusion driving force and enhanced the overall diffusive process. While convective flux dominated total flux during the dialysis session, there was a continuous interference between convection and diffusion fluxes that call for the need to seek minimal interference between these two mechanisms. This is critical for the effective design and operation of high-flux dialyzers.

  10. International

    International Nuclear Information System (INIS)

    Anon.

    1997-01-01

    This rubric reports on 10 short notes about international economical facts about nuclear power: Electricite de France (EdF) and its assistance and management contracts with Eastern Europe countries (Poland, Hungary, Bulgaria); Transnuclear Inc. company (a 100% Cogema daughter company) acquired the US Vectra Technologies company; the construction of the Khumo nuclear power plant in Northern Korea plays in favour of the reconciliation between Northern and Southern Korea; the delivery of two VVER 1000 Russian reactors to China; the enforcement of the cooperation agreement between Euratom and Argentina; Japan requested for the financing of a Russian fast breeder reactor; Russia has planned to sell a floating barge-type nuclear power plant to Indonesia; the control of the Swedish reactor vessels of Sydkraft AB company committed to Tractebel (Belgium); the renewal of the nuclear cooperation agreement between Swiss and USA; the call for bids from the Turkish TEAS electric power company for the building of the Akkuyu nuclear power plant answered by three candidates: Atomic Energy of Canada Limited (AECL), Westinghouse (US) and the French-German NPI company. (J.S.)

  11. Toward the treatment for Alzheimer's disease: adsorption is primary mechanism of removing amyloid β protein with hollow-fiber dialyzers of the suitable materials, polysulfone and polymethyl methacrylate.

    Science.gov (United States)

    Kawaguchi, Kazunori; Saigusa, Akira; Yamada, Shinji; Gotoh, Takehiro; Nakai, Shigeru; Hiki, Yoshiyuki; Hasegawa, Midori; Yuzawa, Yukio; Kitaguchi, Nobuya

    2016-06-01

    The accumulation of amyloid β protein (Aβ) in the brain reflects cognitive impairment in Alzheimer's disease. We hypothesized that the rapid removal of Aβ from the blood by an extracorporeal system may act as a peripheral Aβ sink from the brain. The present study aimed to determine the optimal materials and modality for Aβ removal by hemodialyzers. In a batch analysis, hollow-fiber fragments of polysulfone (PSf) and polymethyl methacrylate (PMMA) showed greater removal efficiency of Aβ than did other materials, such as cellulose-triacetates and ethylene-vinyl alcohol copolymer (PSf:PMMA at 30 min, 98.6 ± 2.4 %:97.8 ± 0.4 % for Aβ1-40 and 96.6 ± 0.3 %:99.0 ± 1.0 % for Aβ1-42). In a modality study, the Aβ solution was applied to PSf dialyzers and circulated in the dialysis and Air-filled adsorption-mode (i.e., the outer space of the hollow fibers was filled with air) or phosphate-buffered saline (PBS)-filled adsorption modes. The Aβ1-40 removal efficiency of the pre/post dialyzer in the Air-filled adsorption-mode was the highest (62.4 ± 12.6 %, p = 0.007). In a flow rate study in the Air-filled adsorption-mode, 200 mL/min showed the highest Aβ1-40 reduction rate of pool solution (97.3 ± 0.8 % at 15 min) compared with 20 mL/min (p = 0.00001) and 50 mL/min (p = 0.00382). PMMA dialyzers showed similar high reduction rates. Thus, the optimal modality for Aβ removal was the adsorption-mode with PSf or PMMA hollow fibers at around 50 mL/min flow rate, which seems to be suitable for clinical use.

  12. Iron, zinc and calcium dialyzability from extruded product based on whole grain amaranth (Amaranthus caudatus and Amaranthus cruentus) and amaranth/Zea mays blends.

    Science.gov (United States)

    Galan, María Gimena; Drago, Silvina Rosa; Armada, Margarita; José, Rolando González

    2013-06-01

    Amaranth is a Native American grain appreciated for its high nutritional properties including high mineral content. The aim of this study was to evaluate the availability of Fe, Zn and Ca from extruded products made with two varieties of amaranth and their mixtures with maize at two levels of replacement. Mineral availability was estimated using dialyzability method. The contents of Fe (64.0-84.0 mg/kg), Ca (1977.5-2348.8 mg/kg) and Zn (30.0-32.1 mg/kg) were higher in amaranth than in maize products (6.2, 19.1, 9.7 mg/kg, respectively). Mineral availability was in the range of (2.0-3.6%), (3.3-11.1%) and (1.6-11.4%) for Fe, Ca and Zn, respectively. Extruded amaranth and amaranth/maize products provide higher amount of Fe and Ca than extruded maize. Extruded amaranth products and amaranth addition to maize could be an interesting way to increase nutritional value of extruded products.

  13. Enhancement of Toxic Substances Clearance from Blood Equvalent Solution and Human Whole Blood through High Flux Dialyzer by 1 MHz Ultrasound

    Directory of Open Access Journals (Sweden)

    Shiran M. B.

    2017-06-01

    Full Text Available Background: Hemodialysis is a process of removing waste and excess fluid from blood when kidneys cannot function efficiently. It often involves diverting blood to the filter of the dialysis machin to be cleared of toxic substances. Fouling of pores in dialysis membrane caused by adhesion of plasma protein and other toxins will reduce the efficacy of the filtre. Objective: In This study, the influence of pulsed ultrasound waves on diffusion and the prevention of fouling in the filter membrane were investigated. Material and Methods: Pulsed ultrasound waves with frequency of 1 MHz at an intensity of 1 W/cm2 was applied to the high flux (PES 130 filter. Blood and blood equivalent solutions were passed through the filter in separate experimental setups. The amount of Creatinine, Urea and Inulin cleared from both blood equvalent solution and human whole blood passed through High Flux (PES 130 filter were measured in the presence and absence of ultrasound irradiation. Samples were taken from the outlet of the dialyzer every five minutes and the clearance of each constituent was calculated. Results: Statistical analysis of the blood equvalent solution and whole blood indicated the clearance of Urea and Inulin in the presence of ultrasound increased (p<0.05, while no significant effects were observed for Creatinine. Conclusion: It may be concluded that ultrasound, as a mechanical force, can increase the rate of clearance of some toxins (such as middle and large molecules in the hemodialysis process.

  14. Enhancement of Toxic Substances Clearance from Blood Equvalent Solution and Human Whole Blood through High Flux Dialyzer by 1 MHz Ultrasound

    Science.gov (United States)

    Shiran, M.B.; Barzegar Marvasti, M.; Shakeri-Zadeh, A.; Shahidi, M.; Tabkhi, N.; Farkhondeh, F.; Kalantar, E.; Asadinejad, A.

    2017-01-01

    Background: Hemodialysis is a process of removing waste and excess fluid from blood when kidneys cannot function efficiently. It often involves diverting blood to the filter of the dialysis machin to be cleared of toxic substances. Fouling of pores in dialysis membrane caused by adhesion of plasma protein and other toxins will reduce the efficacy of the filtre. Objective: In This study, the influence of pulsed ultrasound waves on diffusion and the prevention of fouling in the filter membrane were investigated. Material and Methods: Pulsed ultrasound waves with frequency of 1 MHz at an intensity of 1 W/cm2 was applied to the high flux (PES 130) filter. Blood and blood equivalent solutions were passed through the filter in separate experimental setups. The amount of Creatinine, Urea and Inulin cleared from both blood equvalent solution and human whole blood passed through High Flux (PES 130) filter were measured in the presence and absence of ultrasound irradiation. Samples were taken from the outlet of the dialyzer every five minutes and the clearance of each constituent was calculated. Results: Statistical analysis of the blood equvalent solution and whole blood indicated the clearance of Urea and Inulin in the presence of ultrasound increased (p<0.05), while no significant effects were observed for Creatinine. Conclusion: It may be concluded that ultrasound, as a mechanical force, can increase the rate of clearance of some toxins (such as middle and large molecules) in the hemodialysis process. PMID:28580332

  15. Protective potential of non-dialyzable material fraction of cranberry juice on the virulence of P. gingivalis and F. nucleatum mixed infection.

    Science.gov (United States)

    Polak, David; Naddaf, Raja; Shapira, Lior; Weiss, Ervin I; Houri-Haddad, Yael

    2013-07-01

    Periodontitis is a polymicrobial infectious disease. A novel potential chemical treatment modality may lie in bacterial anti-adhesive materials, such as cranberry juice fractions. The aim of this study is to explore the effect of high molecular weight cranberry constituent (non-dialyzable material [NDM]) on the virulence of a mixed infection with Porphyromonas gingivalis and Fusobacterium nucleatum in mice. In vitro, the anti-adhesive property of NDM was validated on epithelial cell culture, and inhibition of coaggregation was tested using a coaggregation assay. The in vivo effect was tested on the outcome of experimental periodontitis induced by a P. gingivalis and F. nucleatum mixed infection, and also on the local host response using the subcutaneous chamber model of infection. Phagocytosis was also tested on RAW macrophages by the use of fluorescent-labeled bacteria. NDM was found to inhibit the adhesion of both species of bacteria onto epithelial cells and to inhibit coaggregation in a dose-dependent manner. NDM consumption by mice attenuated the severity of experimental periodontitis compared with a mixed infection without NDM treatment. In infected subcutaneous chambers, NDM alone reduced tumor necrosis factor-α (TNF-α) levels induced by the mixed infection. In vitro, NDM eliminated TNF-α expression by macrophages that were exposed to P. gingivalis and F. nucleatum, without impairing their viability. Furthermore, NDM increased the phagocytosis of P. gingivalis. The results indicate that the use of NDM may hold potential protective and/or preventive modalities in periodontal disease. Underlying mechanisms for this trait may perhaps be the anti-adhesive properties of NDM or its potential effect on inflammation.

  16. SureClick® (Darbepoetin alfa) can improve perceived satisfaction and competence for anemia treatment and increase self-administration in non-dialyzed patients with chronic kidney disease.

    Science.gov (United States)

    Bonafont, Xavier; Romero, Ramón; Martínez, Isabel; del Pino, María D; Gil, José M; Aranda, Pedro; Roca, Ramón; Claverol, Joana; Cucala, Mercedes

    2013-01-01

    SureClick® is a prefilled pen for administration of darbepoetin alfa (DA) that is ready-to-use. We explored patient satisfaction with SureClick® compared with prefilled syringes (PFS). Multicenter, prospective, 6-months, observational study in non-dialyzed patients with chronic kidney disease (CKD) treated with DA in PFS who switched to SureClick® at baseline. Main outcomes were: change in Anemia Treatment Satisfaction Questionnaire (ATSQ-S), Perceived Competence for Anemia Scale (PCAS) and self-administration rate. We enrolled 132 patients with a mean(SD) age of 71.3 (14.6) years, 57.6% women. Mean(SD) ATSQ-S scores at baseline and final records were 25.5 (7.9) and 31.6 (4.9) (on a scale from 0 to 36 maximum satisfaction-, mean change: 6.2, 95%CI: 4.6-7.8, pscale from 1 to 7 maximum competence, pperceived competence in anemia management in non-dialyzed CKD patients, and could increase the self-administration rate, thereby reducing use of health resources.

  17. Removal of methadone by extended dialysis using a high cut-off dialyzer: implications for the treatment of overdose and for pain management in patients undergoing light chain removal.

    Science.gov (United States)

    Arelin, Viktor; Schmidt, Julius J; Kayser, Nathalie; Kühn-Velten, W Nikolaus; Suhling, Hendrik; Eden, Gabriele; Kielstein, Jan T

    2016-06-01

    The synthetic opioid methadone hydrochloride has a low molecular weight of 346 D, a high volume of distribution (4 - 7 L/kg), and is lipophilic. It is used as an analgesic and for the maintenance treatment of opiate dependence. In drug addicts, methadone is frequently involved in mixed intoxications that can lead to death. Here we present the case of a drug addict in whom a high cut-off dialysis membrane together with extended dialysis was used in the setting of suspected overdose and acute kidney injury. Although the observed dialyzer plasma clearance (31.5 mL/min) and reduction ratio (38%) were higher than previously reported for standard hemodialysis, the total amount of methadone in the spent dialysate after 1 extended dialysis session was quite low. Hence, even extended dialysis with a high cut-off membrane does not seem to offer a clinically relevant benefit in the setting of overdose for enhanced methadone removal. On the other hand, in patients undergoing high cut-off dialysis for the removal of light chains, methadone could still be used as an analgesic without an additional dose after high cut-off hemodialysis.

  18. International Trade. International Business

    OpenAIRE

    Мохнюк, А. М.; Mokhniuk, A. M.

    2015-01-01

    Work programme of the study course “International Trade. International Business” was prepared in accordance with educational and vocational training program for bachelors of training direction 6.030601 “Management”.

  19. Folded membrane dialyzer with mechanically sealed edges

    Energy Technology Data Exchange (ETDEWEB)

    Markley, F.W.

    A semipermeable membrane is folded in accordion fashion to form a stack of pleats and the edges are sealed so as to isolate the opposite surfaces of the membrane. The stack is contained within a case that provides ports for flow of blood in contact with one surface of the membrane through channels formed by the pleats and also provides ports for flow of a dialysate through channels formed by the pleats in contact with the other surface of the membrane. The serpentine side edges of the membrane are sealed by a solidified plastic material, whereas effective mechanical means are provided to seal the end edges of the folded membrane. The mechanical means include a clamping strip which biases case sealing flanges into a sealed relationship with end portions of the membrane near the end edges, which portions extend from the stack and between the sealing flanges.

  20. Internal Bleeding

    Science.gov (United States)

    ... Fractures (Part II) Additional Content Medical News Internal Bleeding By Amy H. Kaji, MD, PhD, Associate Professor, ... Emergency First Aid Priorities Cardiac Arrest Choking Internal Bleeding Severed or Constricted Limbs or Digits Soft-Tissue ...

  1. International Relations

    OpenAIRE

    McGlinchey, S.

    2017-01-01

    A ‘Day 0’ introduction to International Relations for beginners. Written by a range of emerging and established experts, the chapters offer a broad sweep of the basic components of International Relations and the key contemporary issues that concern the discipline. The narrative arc forms a complete circle, taking readers from no knowledge to competency. The journey starts by examining how the international system was formed and ends by reflecting that International Relations is always adapti...

  2. International law

    CERN Document Server

    Shaw, Malcolm N

    2017-01-01

    International Law is the definitive and authoritative text on the subject, offering Shaw's unbeatable combination of clarity of expression and academic rigour and ensuring both understanding and critical analysis in an engaging and authoritative style. Encompassing the leading principles, practice and cases, and retaining and developing the detailed references which encourage and assist the reader in further study, this new edition motivates and challenges students and professionals while remaining accessible and engaging. Fully updated to reflect recent case law and treaty developments, this edition contains an expanded treatment of the relationship between international and domestic law, the principles of international humanitarian law, and international criminal law alongside additional material on international economic law.

  3. Assessment of dialyzer surface in online hemodiafiltration; objective choice of dialyzer surface area

    OpenAIRE

    Francisco Maduell; Raquel Ojeda; Marta Arias-Guillén; Giannina Bazan; Manel Vera; Néstor Fontseré; Elisabeth Massó; Miquel Gómez; Lida Rodas; Mario Jiménez-Hernández; Gastón Piñeiro; Nayra Rico

    2015-01-01

    Introduction: Online haemodiafiltration (OL-HDF) is most effective technique; several randomised studies and meta-analyses have shown a reduction in mortality, with a directly related association with convective volume. At present, it is not properly established whether the increasing in dialyser surface area may suppose better outcomes in terms of convective and clearance efficacy. The purpose of the study was to assess the effect of increase in dialyser surface area on the convective volume...

  4. internal branding

    OpenAIRE

    Rai, Anu; Omanga, Josphat

    2014-01-01

    The project report provides an insight into internal branding of two different leading firms – Coca-Cola and Google. The aim of this project report is to study how these two companies use internal branding to promote or build brand performance of the company. This report follows a qualitative research method. The report is deductive in nature and hence, it is guided by the literatures of internal branding. The project report conducted research on brand identity, brand commitment and brand loy...

  5. Internal branding

    OpenAIRE

    Rijal, Ramesh; Dhakal, Rajendra

    2015-01-01

    The project report provides an insight into internal branding of two different leading firms – Coca-Cola and Google. The aim of this project report is to study how these two companies use internal branding to promote or build brand performance of the company. This report follows a qualitative research method. The report is deductive in nature and hence, it is guided by the literatures of internal branding. The project report conducted research on brand identity, brand commitment and brand loy...

  6. International cooperation

    International Nuclear Information System (INIS)

    2008-01-01

    In this chapter international cooperation of the Division for Radiation Safety, NPP Decommissioning and Radwaste Management of the VUJE, a. s. is presented. Very important is cooperation with the International Atomic Energy Agency. This cooperation has various forms - national and regional projects of technical cooperation, coordinated research activities, participation of our experts in preparation of the IAEA documentation etc.

  7. International indsats

    DEFF Research Database (Denmark)

    Sachs, Therese

    En analyse af Beredskabsstyrelsens internationale engagement og muligheder for international indsats fremover. Forslag til struktur logistisk og materielt samt til udvikling af personel-kompetencer......En analyse af Beredskabsstyrelsens internationale engagement og muligheder for international indsats fremover. Forslag til struktur logistisk og materielt samt til udvikling af personel-kompetencer...

  8. International Curriculums.

    Science.gov (United States)

    Neal, Larry L.

    This workshop presentation on international curriculums in the field of parks, recreation, leisure, cultural services, and travel/tourism comments that the literature is replete with articles addressing what the field is about, but not about curriculum issues, models, and structure. It reports an international survey of 12 college educators…

  9. International Illiquidity

    DEFF Research Database (Denmark)

    Malkhozov, Aytek; Mueller, Philippe; Vedolin, Andrea

    -predicted effect of funding conditions on asset prices internationally. Global illiquidity lowers the slope and increases the intercept of the international security market line. Local illiquidity helps explain the variation in alphas, Sharpe ratios, and the performance of betting-against-beta (BAB) strategies...

  10. International relations

    International Nuclear Information System (INIS)

    Anon.

    2008-01-01

    Concerning international relations, the different meetings in the field of nuclear safety are reported (Western european nuclear regulator association or Wenra, Nea, IAEA, northern dimension environmental partnership or N.D.E.P., nuclear safety and security group or N.S.S.G., international nuclear regulators association or I.N.R.A.). (N.C.)

  11. International Specialization

    DEFF Research Database (Denmark)

    Kleindienst, Ingo; Geisler Asmussen, Christian; Hutzschenreuter, Thomas

    2012-01-01

    Whether and how international diversification and cross-border arbitrage affects firm performance remains one of the major unresolved research questions in the strategy and international business literatures. We propose that knowing how much a firm has internationally diversified tells us very...... little about performance implications, if we do not know, and do not ask, how the firm has diversified. Therefore, building on the two broad arguments of operating flexibility and location-specific commitment, we develop a theoretical framework that focuses on the extent to which a firm's international...... arbitrage strategy is characterized by specialization versus replication and argue that these different strategies may have differential impact on profitability and risk reduction. Developing a sophisticated measure of international specialization and using a unique panel data set of 92 German MNEs to test...

  12. International Health

    Science.gov (United States)

    ... create refugee populations with immediate and long-term health problems. Some of the major diseases currently affecting ... also an international problem which can affect people's health. Many countries and health organizations are working together ...

  13. Juris International

    CERN Document Server

    A database on international trade law aimed at lawyers and legal counsel in developing and transition economies. Juris International is a multilingual collection (English, Spanish, and French) of legal information on international trade. Juris International aims to facilitate and reduce the work involved in research for business lawyers, advisers and in-house counsel, and state organizations in developing nd transition economies, by providing access to texts which have often been difficult to obtain. Its objective is to gather a large quantity of basic information at one site (favoring complete legal texts), without the need to send for the information, and consequently without excessive communication costs for users who d benefit from an efficient and cheap telecommunications network.

  14. Regulating Internalities

    OpenAIRE

    Sunstein, Cass Robert; Allcott, Hunt

    2015-01-01

    This paper offers a framework for regulating internalities. Using a simple economic model, we provide four principles for designing and evaluating behaviorally-motivated policy. We then outline rules for determining which contexts reliably reflect true preferences and discuss empirical strategies for measuring internalities. As a case study, we focus on energy efficiency policy, including Corporate Average Fuel Economy (CAFE) standards and appliance and lighting energy efficiency standards.

  15. Results of the HepZero study comparing heparin-grafted membrane and standard care show that heparin-grafted dialyzer is safe and easy to use for heparin-free dialysis

    NARCIS (Netherlands)

    Laville, Maurice; Dorval, Marc; Ros, Joan Fort; Fay, Renaud; Cridlig, Joelle; Nortier, Joelle L.; Juillard, Laurent; Debska-Slizien, Alicja; Lorente, Loreto Fernandez; Thibaudin, Damien; Franssen, Casper; Schulz, Michael; Moureau, Frederique; Loughraieb, Nathalie; Rossignol, Patrick

    2014-01-01

    Heparin is used to prevent clotting during hemodialysis, but heparin-free hemodialysis is sometimes needed to decrease the risk of bleeding. The HepZero study is a randomized, multicenter international controlled open-label trial comparing no-heparin hemodialysis strategies designed to assess

  16. International Criminalization of International Terrorizm

    Directory of Open Access Journals (Sweden)

    Alexander Grigoryevich Volevodz

    2014-01-01

    Full Text Available Analysis and studying of the terrorism in all its facets is a complex entangled problem with less clear legal regulation that it might seem at first glance, especially after its transformation from local phenomenon into a world threat. Hitherto terrorism and actions connected to it have been criminalized by the majority of states. There are in modern criminal law whole systems of rules on criminal liability for terrorism which differs considerably from country to country. Terrorism has been criminalized in numerous international regional and universal antiterrorist legal instruments. The author notes that differences in definitions that are enshrined in them hinders international cooperation in criminal matters with respect to terrorist cases. Difficulties reside in the necessity to meet the dual criminality requirement and in the political offense exception. These difficulties can only be overcome through elaboration of a universally recognized definition of the notion of international terrorism and making it legally binding via its inclusion into a universal convention. The issue of definition of international terrorism is an important part of an efficient mutual assistance among states in fight against this crime. In this article the author accounts of actual ways of tackling by the international community of the issue of criminalization of international terrorism and of factors influencing them.

  17. International Relations:

    DEFF Research Database (Denmark)

    This is the textbook for the Open University module International Relations: Continuity and Change in Global Politics. Instead of leading with a succession of theoretical 'isms', the module structures its presentation of the subject around six teaching ‘blocks’, each of which explores a dilemma...... • Block 6: Continuity or change in global politics? Each block introduces new IR theories through discussions of the substantive dilemmas and adds in a layered way levels of analysis and conceptual complexity......., or dimension of variation. The dilemmas in question were chosen for the way they capture key themes in the field of International Studies (IR) as well as central aspects of the ‘international’ itself (ir). The six Blocks are: • Block 1: Co-operation or conflict? Introducing international relations • Block 2...

  18. International cooperation

    International Nuclear Information System (INIS)

    Prieto, F.E.

    1984-01-01

    It looks doubtless that the need for an international cooperation to solve the worldwide energy problems is already a concern of individuals, institutions, and governments. This is an improvement. But there is something lacking. The author refers to the Atoms for Peace speech, the origin of the IAEA and of the subsequent spreading of the nuclear option. He also refers back to the call made by the Mexican government for a worldwide energy cooperation. He stresses the need for governments to cooperate, so that this international cooperation on energy can be put into operation for the benefit of mankind

  19. International collaboration

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    In the wake of the demise of the US Superconducting Supercollider (SSC) project last year which empoverished both US and world science, some rapid scene shifting is going on. The SSC may be dead, but the underlying physics quest lives on. In the US, the 'future vision' subpanel of the High Energy Physics Advisory Board (HEPAP) is at work formulating its recommendations. On the international front, the International Committee for Future Accelerators (ICFA) at a special meeting in Vancouver in January drafted a statement

  20. Transparency International

    NARCIS (Netherlands)

    Hulten, van M. (Michel)

    2009-01-01

    Established in 1993, Transparency International (TI) defines itself as “the global civil society organization leading the fight against corruption, that brings people together in a powerful worldwide coalition to end the devastating impact of corruption on men, women and children around the

  1. International Entomology

    Science.gov (United States)

    Pests and diseases of plants in agriculture are a shared international problem. Yet some of the very places that pest invaders come from often lack the institutional structure and organization necessary to help in understanding the biology of the pest or disease. Strengthening entomology by stimulat...

  2. International safeguards

    International Nuclear Information System (INIS)

    Sanders, B.; Ha Vinh Phuong

    1976-01-01

    Since the start of the post-war era, international safeguards were considered essential to ensure that nuclear materials should not be diverted to unauthorised uses. In parallel, it was proposed to set up an international atomic energy agency within the United Nations through which international cooperation in nuclear matters would be channelled and controlled. Created in 1957, the IAEA was authorized to administer safeguards in connection with any assistance it provided as well as at the request of Member State and of any party to bilateral or multilateral arrangements in its ambit. Today, there are two international treaties requiring that its parties should accept Agency safeguards unilaterally, the Latin America Tlatelolco Treaty of 1967, and the Treaty on the Non-Proliferation of Nuclear Weapons (NPT), operative since 1970, which requires in particular that non-nuclear weapon states should accept Agency safeguards on its peaceful nuclear activities. Thus while NPT covers peaceful nuclear activities indiscriminately in a country, the Agency's original safeguards system is applied according to specific agreements and to given facilities. A basic conflict has now emerged between commercial interests and the increasing wish that transfer of nuclear equipment and know-how should not result in proliferation of military nuclear capacity; however, serious efforts are currently in progress to ensure universal application of IAEA safeguards and to develop them in step with the uses of nuclear energy. (N.E.A.) [fr

  3. Internal pump

    International Nuclear Information System (INIS)

    Kushima, Jun; Hayashi, Youjiro; Ueda, Masayuki.

    1997-01-01

    The present invention relates to an internal pump. A water hole allowing communication between internal and external circumferences of a stretch tube is provided at the portion of the stretch tube corresponding to a position where an end face of a nozzle portion of a motor case and an end face of a diffuser are joined with each other so that hot filtered water inside a pressure container which has entered from where the end face of the nozzle portion of the motor case and the end face of the diffuser are joined with each other is combined with the purged water so that it can be sent back to the pressure container again. (author) figs

  4. International safeguards

    International Nuclear Information System (INIS)

    1995-01-01

    The system of international safeguards carried out by the IAEA is designed to verify that governments are living up to pledges to use nuclear energy only for peaceful purposes under the NPT (Treaty on the non-proliferation of nuclear weapons) and similar agreements. The film illustrates the range of field inspections and analytical work involved. It also shows how new approaches are helping to strengthen the system

  5. International cooperation

    International Nuclear Information System (INIS)

    1996-01-01

    In 1995, Nuclear Regulatory Authority of the Slovak Republic (NRA SR) ensured foreign cooperation particularly in the frame of the Slovak Republic is membership in the IAEA, as well as cooperation with the Nuclear Energy Agency of the Organization for Economic Cooperation and Development (OECD NEA), cooperation with European Union in the frame of PHARE programmes, and intergovernmental cooperation and cooperation among nuclear regulatory authorities. With respect to an international importance, prestige and a wide-scope possibilities of a technical assistance , either a direct one (expert assessments, technology supplies, work placement, scientific trips, training courses) or indirect one (participation at various conferences, seminars, technical committees, etc), the most important cooperation with the IAEA in Vienna. In 1994, the Slovak Republic, was elected to the Board Governors, the represent the group of Eastern European countries. The Slovak Government entrusted the NRA SR's Chairman with representing the Slovak Republic in the Board of Governors. Owing to a good name of Slovakia was elected to the one of two Vice-Chairmen of the Board of Governors at the 882-nd session on the Board. IAEA approved and developed 8 national projects for Slovakia in 1995. Generally, IAEA is contracting scientific contracts with research institutes, nuclear power plants and other organizations. Slovak organizations used these contracts as complementary funding of their tasks. In 1995, there were 12 scientific contracts in progress, or approved respectively. Other international activities of the NRA SR, international co-operations as well as foreign affairs are reported

  6. Internal education

    Directory of Open Access Journals (Sweden)

    Anita Zagorc

    2016-09-01

    Full Text Available Research Question (RQ: The importance of internal trainings in an organization. Purpose: The purpose of research is to examine and present internal trainings in an organization and their contribution to greater success of an organization. The paper studies employee training in a company, how the organization itself looks after its employees during training, how trainings contribute to further development of organization and the advancement of knowledge for successful operation of organization. Method: How to achieve the purpose of research, used methods and theoretical approach. Results: Specific examples and opinions of employees. Results show the importance of trainings for an organization. We can see that all employees are fairly motivated and ready to participate in trainings and can adapt to changing business environment very well. The results demonstrate that all trainings in the organization are very important and welcome. Only with continuous learning, the organization can be successful and survive in the market despite strong competition. Organization: Trainings are designed for all employees inside an organization. Different employees participate in trainings in a different way as all trainings are divided into certain work and fields that are important for each individual or department in an organization. Society: Trainings have an impact on the whole organization by contributing to its development. Originality: The originality of study is what was new in the research, what is the value and originality of research. Limitations/Future Research: Research was limited to a small number of sources.

  7. International safeguards

    International Nuclear Information System (INIS)

    Petit, A.

    1991-01-01

    The IAEA has now 200 Inspectors or so, and Euratom a similar number. People in Vienna are talking about increases of this staff, in the range of a possible doubling in the five years to come, although even an immediate restart of the expansion of nuclear industry, would not materialize significantly within this period. This means that keeping the same safeguarding approach would probably lead to another doubling of such staff in the ten following years, which is completely unrealistic. Such a staff is our of proportion with those of national inspectorates in other fields. The paper analyzes the basic irrealistic dogma which have hindered the progress of international safeguards, and recall the suggestions made since ten years to improve them

  8. International recommendations

    International Nuclear Information System (INIS)

    Lindell, Bo

    1986-01-01

    Full text: This short presentation will indicate the general radiation protection background to protective measures against foodstuffs contaminated with radioactive substances. A number of international organizations are involved in various aspects of radiation protection, for example, the International Atomic Energy Agency (IAEA), the United Nations Food and Agriculture Organization (FAO), the United Nations Environment Programme (UNEP), and the World Health Organization (WHO). Two international organizations, however, provide the basic background. These are the International Commission on Radiological Protection (ICRP) and the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). UNSCEAR provides the scientific information on radiation levels and effects. It consists of 21 member countries, with truly international coverage. It issues reports to the UN General Assembly, including comprehensive scientific annexes. Its latest comprehensive report was issued in 1982, the next is expected to be published in 1988. That report will include an assessment of the radiological consequences of the Chernobyl accident. The ICRP is a non-governmental organization. It has issued recommendations on radiation protection since 1928. The postulated biological basis for radiation protection recommendations involves two types of biological effects. The so-called non-stochastic effects, mainly due to cell death, appear only when the radiation doses exceed a certain threshold value. These effects, therefore, can only appear after high accidental exposures. After the Chernobyl accident, they only affected about 200 individuals involved in fire extinction and rescue work at the damaged nuclear power plant. Stochastic effects, with some simplification, may be seen as the result of initial changes in the genetic code of some surviving cells. If these cells are germ cells, this may lead to hereditary harm. If they are somatic cells, the result could be cancer

  9. International relations

    International Nuclear Information System (INIS)

    Anon.

    2009-01-01

    The French nuclear safety authority (A.S.N.) has participated at different meeting in European Union as nuclear decommissioning assistance programme(N.D.A.P.), Regulatory assistance management group (R.A.M.G.) and Instrument for nuclear safety cooperation (I.N.S.C.). The members of Western European nuclear regulator association (W.E.N.R.A.) met and discussed about the future of W.E.N.R.A. and its representativeness and its cooperation with European nuclear safety regulator group (E.N.S.R.E.G.) and head of European radiation control authorities (H.E.R.C.A.). About International relations it is to noticed a meeting at the invitation of IAEA to discuss about the possibility to resort to the Ines scale for medical events. An audit mission under the IAEA aegis stood at Fessenheim, O.S.A.R.T. for operational safety review team. Two years and a half passed by between the audit mission Integrated regulatory review service (I.R.S.S.) welcome by A.S.N. in november 2006 and the audit mission follow up in 2009, 12 experts from 11 different countries and coordinated by three representatives of IAEA worked, the conclusions were that 90% of recommendations made to A.S.N. in 2006 were treated in a satisfying way; the evaluation gives three new recommendations, 7 new suggestions and 11 new correct practices. A meeting of the commission on safety standards (C.S.S.) stood in april 2009. Some others meeting are to be noticed: nuclear safety and security group (N.S.S.G.), expert group on nuclear and radiation safety (E.G.N.R.S.) instituted by the council of the Baltic sea states (C.B.S.S.) treats data exchange on the national networks of dose rates and surveillance of radioactivity in air. International nuclear regulator association (I.N.R.A.) held its first meeting in april 2009 at Seoul (Korea). Bilateral relations with Poland, Italy, Ukraine and Germany planed cooperation or information exchange in the field of nuclear safety. Participation to conference in Usa, meetings with United

  10. International perspective

    International Nuclear Information System (INIS)

    2003-01-01

    The workshop dealt with two distinct cases: - In Port Hope - an existing situation impacting a set of communities affected by the nuclear fuel industry since the 1930's. This situation concerns the remediation of soil 'tainted' by a low level of radioactivity resulting from the processing of uranium. The facility that produced those wastes is still in town but it has changed ownership and it no longer stores or disposes of the waste in the area. - The issuance and upcoming implementation of the Nuclear Fuel Waste Act (NWF Act) charting a path towards the identification of a national, long-term management solution for nuclear fuel (high level) waste in Canada. The NWF Act restarts a process that was interrupted a few years ago, after the Seaborn Environmental Assessment Panel concluded that the solution proposed by proponent Atomic Energy Canada Ltd. had not been demonstrated to have broad public support. From an international perspective, numerous observations can be made and lessons can be drawn both from the individual and the combined cases. Some of the most prominent observations, in the view of the NEA Secretariat, are presented hereafter. (author)

  11. Internal Audit Service | Internal Audit Service

    Science.gov (United States)

    their internal auditing function in the areas of professional excellence, quality of service and Students and teachers Media Internal Audit Service Navbar Toggle Home About the Staff Risk Assessment and Planning Internal Audit Process Search for Search Home The mission of the Fermilab Internal Audit Service

  12. Fundamental Characteristics of the Newly Developed ATA™ Membrane Dialyzer.

    Science.gov (United States)

    Sunohara, Takashi; Masuda, Toshiaki

    2017-01-01

    Dialysis membranes are often made from synthetic polymers, such as polysulfone. However, membranes made from cellulose triacetate have superior biocompatibility and have been used since the 1980s. On-line hemodiafiltration treatment accompanied by massive fluid replacement is increasingly being used in Europe and Japan, but cellulose triacetate is not suitable for this treatment. Our newly developed asymmetric triacetate membrane, the ATA™ membrane, substantially improved the filtration properties and blood compatibility because of the asymmetric structure and smooth surface of this cellulose acetate membrane. Key Message: The ATA membrane maintains its high permeability even after massive filtration and shows less temporal variation in its permeation performance, lower protein adsorption, and superior biocompatibility compared with conventional membranes. © 2017 S. Karger AG, Basel.

  13. Dose setting for radiation sterilization of dialyzers, (2)

    International Nuclear Information System (INIS)

    Kigawa, Akiko; Tateishi, Tsuneo; Iso, Katsuaki; Kimura, Toshio; Mamuro, Tetsuo; Misawa, Sho.

    1986-01-01

    It was found in the preceding study that the strain that showed the highest radiation resistance among the strains washed out of dializers not yet sterilzed was Bacillus megaterium and the D-value of its spore was about 40 percent higher than that of B. pumilus ATCC 27142 spore. In the present study, bundles of hollow fibers were inoculated with spores of both the B. megaterium and the B. pumilus and D-values of the spores were measured to be 0.24 7 and 0.16 9 Mrad, respectively. The dializer is consisted of several materials. Sterilization effect of gamma-ray irradiation is the least for hollow fibers, because they contain glycerin. It is concluded that 10 6 sterility assurance is achieved by setting the sterilization dose at 2.0 Mrad, about eight times of the D-value for the B. megaterium under the condition that the number of contaminants per product is less than 100. (author)

  14. International Ecohealth Forum 2008 | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... the International Forum on Ecosystem Approaches to Human Health (Montreal, ... the International Association of Ecology and Health (IAEH), and a Brazilian ... Nutrition, health policy, and ethics in the age of public-private partnerships.

  15. Nuclear fuel cycle: international market, international constraints and international cooperation

    International Nuclear Information System (INIS)

    Imai, R.

    1977-01-01

    Some of the constraints on the nuclear fuel cycle are ones arising from economic and financial reasons, those caused by uranium resources and their distribution, those arising from technical reasons, issues of public acceptance, and those quite independent of normal industrial considerations, but caused by elements of international politics. The nuclear fuel cycle and the international market, matters of nuclear non-proliferation, and international cooperation are discussed

  16. Internal Affairs Allegations

    Data.gov (United States)

    Montgomery County of Maryland — This dataset contains allegations brought to the attention of the Internal Affairs Division either through external complaints or internal complaint or recognition....

  17. The Internal Audit Outsourcing

    Directory of Open Access Journals (Sweden)

    Grzegorz Gołębiowski

    2010-06-01

    Full Text Available The article explores an issue of the internal audit outsourcing. It indicates the differences between internal audit, outsourcing and cosourcing of this service as well as their advantages and disadvantages. Drawing from the research on internal audit outsourcing the recent market trends were identified as well as motivations for choosing different forms of internal auditing.

  18. The International Criminal Court

    DEFF Research Database (Denmark)

    Damgaard, Ciara Therése

    This article considers whether acts of international terrorism can and should be prosecuted before the International Criminal Court as crimes against humanity.......This article considers whether acts of international terrorism can and should be prosecuted before the International Criminal Court as crimes against humanity....

  19. Models og International Entrepreneurship

    DEFF Research Database (Denmark)

    Rask, Morten; Servais, Per

    2015-01-01

    on International Entrepreneurship, and specifically but not exclusively, International New Ventures (INVs). The three resulting ‘meta-models’ depict the activities and loci of such firms, the motivating factors that give rise to such firms and their growth modalities and strategies. These models reflect the merger...... of entrepreneurship and international business into the field of international entrepreneurship....

  20. Models of international entrepreneurship

    DEFF Research Database (Denmark)

    Rask, Morten; Servais, Per

    2012-01-01

    on International Entrepreneurship, and specifically but not exclusively, International New Ventures (INVs). The three resulting ‘meta-models’ depict the activities and loci of such firms (Figure 1), the motivating factors that give rise to such firms (Figure 2) and their growth modalities and strategies (Figure 3......). These models reflect the merger of entrepreneurship and international business into the field of international entrepreneurship. Managers in international entrepreneurial firms and students in international business and entrepreneurship can use the models as framework for understanding international...... entrepreneurship....

  1. Internal Control: Peran Dan Perkembangannya

    OpenAIRE

    Murtin, Alek

    2000-01-01

    Perhatian terhadap pentingnya internal control dalam organisasi berjalan dari waktu ke waktu untuk meningkatkan fungsi internal control yang disesuaikan dengan perkembangan lingkungan organisasi, dimulai dengan adanya internal check, kemudian internal control system, internal control structure dan terakhir adalah internal control-integrated framework. Internal control system sempat berkembang beberapa tahun di Indonesia yang selanjutnya digantikan oleh internal control structure yang digunaka...

  2. International aspects of fusion

    International Nuclear Information System (INIS)

    Stacey, W.M. Jr.

    1979-12-01

    International collaborative efforts in magnetic confinement fusion in which the USA is involved are reviewed. These efforts are carried under the auspices of international agencies and through bilateral agreements

  3. International images: business cards.

    Science.gov (United States)

    Gaston, S; Pucci, J

    1991-01-01

    Nursing specialists engage in a variety of international professional activities. Business cards are an important aspect of establishing a professional image. This article presents recommended business card contents, international etiquette, card design and production, and cared innovations.

  4. International trade and environment

    International Nuclear Information System (INIS)

    Posada L, Luis Guillermo

    2000-01-01

    Topics are presented as economic theory and theory of the international trade, international dimension of the environmental problems, economic prosperity, environmental quality and lineament are given for an alternative, among others

  5. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, Mohammad Akbar Hosain

    2014-12-04

    Various examples are provided for generalized internal multiple imaging (GIMI). In one example, among others, a method includes generating a higher order internal multiple image using a background Green\\'s function and rendering the higher order internal multiple image for presentation. In another example, a system includes a computing device and a generalized internal multiple imaging (GIMI) application executable in the computing device. The GIMI application includes logic that generates a higher order internal multiple image using a background Green\\'s function and logic that renders the higher order internal multiple image for display on a display device. In another example, a non-transitory computer readable medium has a program executable by processing circuitry that generates a higher order internal multiple image using a background Green\\'s function and renders the higher order internal multiple image for display on a display device.

  6. International energy outlook, 2010

    Science.gov (United States)

    2010-07-01

    This report presents international energy projections through 2035, : prepared by the U.S. Energy Information Administration, including outlooks : for major energy fuels and associated carbon dioxide emissions. The International Energy Outlook 2010 (...

  7. International diversification and Microfinance

    NARCIS (Netherlands)

    Galema, R.; Lensink, B.W.; Spierdijk, L.

    2011-01-01

    International commercial banks, institutional investors, and private investors have become increasingly interested in financing microfinance institutions (MFIs). This paper investigates whether adding microfinance funds to a portfolio of risky international assets yields diversification gains. By

  8. International diversification and Microfinance

    NARCIS (Netherlands)

    Galema, Rients; Lensink, Robert; Spierdijk, Laura

    International commercial banks, institutional investors, and private investors have become increasingly interested in financing microfinance institutions (MFIs). This paper investigates whether adding microfinance funds to a portfolio of risky international assets yields diversification gains. By

  9. Alternative international currencies

    Directory of Open Access Journals (Sweden)

    Rozhentsova Vladimirovna Elena

    2012-01-01

    Full Text Available The modern international monetary system has a number of flaws and therefore needs cardinal change. Hence, economists from all over the world are suggesting alternative international currencies that would make the international monetary system more efficient. However, it is essential when approaching the creation of a new international currency to analyze and take into account the experience of all the past international currencies. Therefore this paper begins with an exploration of the drawbacks of each of the past and present international currencies. Drawing on this analysis a justification will be made for the necessity of introducing a new international currency, pointing to the requirements it should meet. Further on, this paper proposes an alternative theoretically possible variant of the international currency, with a fixed value relative to a commodity basket. An abstract example is used to demonstrate its composition and circulation mechanism.

  10. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, Mohammad Akbar Hosain; Alkhalifah, Tariq

    2014-01-01

    Various examples are provided for generalized internal multiple imaging (GIMI). In one example, among others, a method includes generating a higher order internal multiple image using a background Green's function and rendering the higher order internal multiple image for presentation. In another example, a system includes a computing device and a generalized internal multiple imaging (GIMI) application executable in the computing device. The GIMI application includes logic that generates a higher order internal multiple image using a background Green's function and logic that renders the higher order internal multiple image for display on a display device. In another example, a non-transitory computer readable medium has a program executable by processing circuitry that generates a higher order internal multiple image using a background Green's function and renders the higher order internal multiple image for display on a display device.

  11. International double taxation

    OpenAIRE

    Körbl, Hugo

    2012-01-01

    1 Summary This thesis deals with the issue of international double taxation of income and capital and methods for its solution. International double taxation is an issue which states began to deal with in the late 19th century. This interest intensified after the First World War when also the League of Nations (predecessor of the United Nations) began to deal with international double taxation. Most attention the phenomenon of double taxation of income and capital with an international elemen...

  12. International Construction Measurement Standard

    OpenAIRE

    Mitchell, Charles

    2016-01-01

    The International Construction Measurement Standard Coalition (the Coalition) was formed on 17 June 2015 after meeting at the International Monetary Fund in Washington DC, USA. The Coalition, comprising the organisations listed below at the date of publication, aims to bring about consistency in construction cost reporting standards internationally. This is achieved by the creation and adoption of this ICMS, an agreed international standard for the structuring and presentation of cost reports...

  13. A Realistic International Economics.

    Science.gov (United States)

    Culbertson, John M.

    1987-01-01

    Criticizes college textbooks for adopting a "party line" of laissez-faire economic doctrine which asserts the benefits of free trade. Offers an alternative interpretation of international trade, covering such topics as the effect of unregulated international trade on wage levels, and international lending. (JDH)

  14. UNCLOS and International Law

    DEFF Research Database (Denmark)

    Martinez Romera, Beatriz; Coelho, Nelson F.

    2018-01-01

    , treaty law is only one of many sources of the law that governs international relations, the others being customary international law and principles of law. The main conclusion of this chapter is that states may have to wake up to the limitations of the UNCLOS and that this will require understanding...... the relative role of this treaty among other sources of international law....

  15. Petroleum and international policy

    International Nuclear Information System (INIS)

    Pertuzio, A.

    2002-01-01

    To illustrate the relation between the petroleum and the international policy, the author presents the place of the petroleum industry in the international relations by an analysis of the historical aspects, the states and international organizations interventions and the prices evolution. (A.L.B.)

  16. Unit III: International Conflict.

    Science.gov (United States)

    Maxey, Phyllis

    1983-01-01

    This lesson helps students understand the global network involved in international events. Students have an opportunity to examine the impact of international law and the role of international organizations, national governments, and private individuals in the effort to secure the release of United States hostages in Iran. (AM)

  17. International Corporate Debt Market

    OpenAIRE

    Manuela Geranio; Issam Hallak

    2012-01-01

    Research on international debt markets has chiefly investigated sovereign debt markets. We suggest a review of the different types of borrowers and the differences in the instruments. In particular we show that syndicated loans are an essential tool of international debt markets to monitor international markets borrowers. We also show by looking at the details of these instruments the mechanisms behind such tools.

  18. Neurology and international organizations.

    Science.gov (United States)

    Mateen, Farrah J

    2013-07-23

    A growing number of international stakeholders are engaged with neurologic diseases. This article provides a brief overview of important international stakeholders in the practice of neurology, including global disease-specific programs, United Nations agencies, governmental agencies with international influence, nongovernmental organizations, international professional organizations, large private donors, private-public partnerships, commercial interests, armed forces, and universities and colleges. The continued engagement of neurologists is essential for the growing number of international organizations that can and should incorporate neurologic disease into their global agendas.

  19. Windows® Internals

    CERN Document Server

    Russinovich, Mark E; Ionescu, Alex

    2009-01-01

    See how the core components of the Windows operating system work behind the scenes-guided by a team of internationally renowned internals experts. Fully updated for Windows Server 2008 and Windows Vista, this classic guide delivers key architectural insights on system design, debugging, performance, and support-along with hands-on experiments to experience Windows internal behavior firsthand.Delve inside Windows architecture and internals:Understand how the core system and management mechanisms work-from the object manager to services to the registryExplore internal system data structures usin

  20. International safeguards and international nuclear trade

    International Nuclear Information System (INIS)

    Felten, P.

    1991-01-01

    A particular feature of nuclear trade is the need to ensure a good equilibrium between technology transfer and the requirements linked to non proliferation of nuclear weapons. The recent dramatic changes that occurred on the international scene have particularly underlined the difficulty to reach this equilibrium, reminding us the fragility of the existing order and the responsibility of the nuclear community in the field of non-proliferation. Consequently, there is a need for an international thorough review of the actual non proliferation tools developed until now. This review could lead to reconsider some of the dogmas upon which the present safeguard system is based

  1. International network competition

    OpenAIRE

    Tangerås, Thomas P.; Tåg, Joacim

    2014-01-01

    We analyse network competition in a market with international calls. National regulatory agencies (NRAs) have incentives to set regulated termination rates above marginal cost to extract rent from international call termination. International network ownership and deregulation are alternatives to combat the incentives of NRAs to distort termination rates. We provide conditions under which each of these policies increase efficiency and aggregate welfare. Our findings provide theoretical suppor...

  2. International business transactions

    OpenAIRE

    Buczkowski, Bogdan

    2016-01-01

    Running a business on an international scale requires not only a substantial body of knowledge but also the ability to apply it in practice. That is why our textbook, with a vast collection of practical examples, discusses a wide variety of pertinent issues connected with business operations in international markets, from international market analysis, drafting business plans, concluding business transactions and the insurance of goods through to customs clearance procedures and professional ...

  3. Emancipating Labor Internationalism

    OpenAIRE

    Waterman, Peter

    2004-01-01

    The secular trinity of c19th socialism was Labor-Internationalism-Emancipation. As early-industrial capitalism developed into a national-industrial-colonial capitalism, the internationalism of labor became literally international, and simultaneously lost its emancipatory aspiration and capacity (or vice versa). The dramatic – and labor-devastating – development of a globalised-networked-informatised capitalism is raising the necessity and possibility of a new kind of labor internationalis...

  4. Dosimetry of internal emitters

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    The Dosimetry of Internal Emitter Program endeavors to refine the correlation between radiation dose and observed biological effects. The program is presently engaged in the development of studies that will demonstrate the applicability of microdosimetry models developed under the Microdosimetry of Internal Sources Program. The program also provides guidance and assistance to Pacific Northwest Laboratory's Biology Department in the dosimetric analysis of internally deposited radionuclides. This report deals with alpha particle dosimetry plutonium 239 inhalation, and in vitro studies of chromosomal observations

  5. Editorial: International Entrepreneurial Orientation

    OpenAIRE

    Krzysztof Wach

    2015-01-01

    In recent decades, both the theory of internationalisation of the firm and/or the theory of international business have developed. Recent developments in international business studies prove that entrepreneurial orientation (EO) emerges as one of the important potential factors contributing to the intensification of the processes of internationalisation of the firm (Etemad, 2015; Gupta & Gupta, 2015). It seems that international entrepreneurship (IE) has been flourishing. The general theory o...

  6. International Research Chairs Initiative | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The International Research Chairs Initiative (IRCI) is a seven-year, CA$8 million research program that pairs top research talent from universities in Canada with their counterparts in developing countries to address key ... The results of this joint effort: world-class discoveries and healthier, wealthier, fairer societies.

  7. International Aid Transparency Initiative (IATI) | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    By offering a common format and central repository, the IATI improves the transparency, accountability, and effectiveness of international aid. It is used ... organizations. IDRC is one of almost 400 participants who publish project titles and descriptions, country and geographic area, aid type, dates, and budget information.

  8. Internal disruption in tokamaks

    International Nuclear Information System (INIS)

    Kuvshinov, B.N.; Savrukhin, P.V.

    1990-01-01

    A review of results of experimental and theoretical investigations of internal disruption in tokamaks is given. Specific features of various types of saw-tooth oscillations are described and their classification is performed. Theoretical models of the process of development of internal disruption instability are discussed. Effect of internal disruption on parameters of plasma, confined in tokamak, is considered. Scalings of period and amplitude of saw-tooth oscillations, as well as version radius are presented. Different methods for stabilizing instability of internal disruption are described

  9. EM International. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

  10. Internal disruptions in tokamaks

    International Nuclear Information System (INIS)

    Kuvshinov, B.N.; Savrukhin, P.V.

    1990-01-01

    Experimental and theoretical studies of the phenomenon of internal disruptions in tokamaks are reviewed. A classification scheme is introduced and the features of different types of sawtooth oscillations are described. A theoretical model for the development of the internal disruption instability is discussed. The effect of internal disruptions on the parameters of plasma confined in tokamaks is discussed. Scaling laws for the period and amplitude of sawtooth oscillations, as well as for the inversion radius, are presented. Different methods of stabilizing the internal disruption instability are described

  11. BWR internals life assurance

    International Nuclear Information System (INIS)

    Herrera, M.L.; Stancavage, P.P.

    1988-01-01

    Boiling water reactor (BWR) internal components play an important role in power plant life extension. Many important internals were not designed for easy removal and changes in material properties and local environmental effects due to high radiation makes stress corrosion cracking more likely and more difficult to correct. Over the past several years, operating experience has shown that inspection, monitoring and refurbishment can be accomplished for internal structures with existing technology. In addition, mitigation techniques which address the causes of degradation are available to assure that life extension targets can be met. This paper describes the many considerations and aspects when evaluating life extension for reactor vessel internals

  12. Publishing International Counseling Articles

    Science.gov (United States)

    Hohenshil, Thomas H.; Amundson, Norman E.

    2011-01-01

    This article begins with a rationale for including international articles in the "Journal of Counseling & Development." Then, 2 general categories of international articles are described. First are articles that provide a general overview of counseling in a particular country. The 2nd category is more general and might involve international…

  13. International Entrepreneurship and Sourcing

    DEFF Research Database (Denmark)

    Servais, Per; Zucchella, Antonella; Palamera, Giada

    2006-01-01

    This contribution focuses on international sourcing as an entrepreneurial act and aims at demonstrating that it is actually at the core of internationalization processes of small firms, both established and international new ventures. Another issue of this research is to understand how these firm...

  14. International Student Success

    Science.gov (United States)

    Smith, Clayton

    2016-01-01

    This article, with a focus on North American postsecondary education, identifies international students as a strategic enrollment management institutional priority; presents themes in the international student retention, satisfaction, and success research literature; and describes related best practices. It also presents the findings from an…

  15. International Trade and Protectionism.

    Science.gov (United States)

    Stanford Univ., CA. Stanford Program on International and Cross Cultural Education.

    This unit is designed to investigate the reasons for international trade and the issue of trade protectionism by focusing on the case study of the U.S. trade relationship with Taiwan. The unit begins with a simulation that highlights the concepts of global interdependence, the need for international trade, and the distribution of the world's…

  16. Wording in international law

    NARCIS (Netherlands)

    d' Aspremont, J.

    2012-01-01

    Since the demise of philosophical foundationalism and that of the Aristotelian idea of an inner meaning of words, scholarship about international law is no longer perceived as a mining activity geared towards the extraction of pre-existing meaning. Rather, international legal scholarship is in a

  17. Wording in International Law

    NARCIS (Netherlands)

    d' Aspremont, J.

    2012-01-01

    Since the demise of philosophical foundationalism and that of the Aristotelian idea of an inner meaning of words, the scholarship about international law is no longer perceived as a mining activity geared towards the extraction of pre-existing meaning. Rather, international legal scholarship is in a

  18. OCRWM international procedures

    International Nuclear Information System (INIS)

    1986-03-01

    These international procedures provide guidance and assistance for the Office of Civilian Radioactive Waste Management (OCRWM) and for OCRWM Project Offices, contractors and subcontractors in conducting international activities. They supplement the relevant Department of Energy (DOE) orders (which are referenced), not supplant them

  19. International Cancer Screening Network

    Science.gov (United States)

    The International Cancer Screening Network promotes evidence-based cancer screening implementation and evaluation with cooperation from multilateral organizations around the globe. Learn more about how ICSN aims to reduce the global burden of cancer by supporting research and international collaboration.

  20. International Youth Nuclear Congress

    International Nuclear Information System (INIS)

    Fern, A.

    2017-01-01

    International Youth Nuclear Congress (IYNC) was Initiated by an international YG group of enthusiasts in 1997. Mission statement developed at ENC1998 in Nice, France Growth in enthusiasm and support: IAEA, Nuclear Societies, companies. IYNC run by the Young Generation with full support of experienced advisors, nuclear societies and companies. First came to African continent when IYNC 2010 was hosted by South Africa

  1. Internal Evaluation, Historically Speaking

    Science.gov (United States)

    Mathison, Sandra

    2011-01-01

    The author analyzes the growth and nature of internal evaluation from the 1960s to the present and suggests that internal evaluation has been on the increase because of its perceived importance. Although the 1960s were characterized by a rich intellectual development of evaluation theory and practice, the fiscal conservatism of the 1980s ushered…

  2. Modeling Internal Radiation Therapy

    NARCIS (Netherlands)

    van den Broek, Egon; Schouten, Theo E.; Pellegrini, M.; Fred, A.; Filipe, J.; Gamboa, H.

    2011-01-01

    A new technique is described to model (internal) radiation therapy. It is founded on morphological processing, in particular distance transforms. Its formal basis is presented as well as its implementation via the Fast Exact Euclidean Distance (FEED) transform. Its use for all variations of internal

  3. International Fisheries Agreements

    DEFF Research Database (Denmark)

    Pintassilgo, Pedro; Kronbak, Lone Grønbæk; Lindroos, Marko

    2015-01-01

    This paper surveys the application of game theory to the economic analysis of international fisheries agreements. The relevance of this study comes not only from the existence of a vast literature on the topic but especially from the specific features of these agreements. The emphasis of the survey...... is on coalition games, an approach that has become prominent in the fisheries economics literature over the last decade. It is shown that coalition games were first applied to international fisheries agreements in the late 1990s addressing cooperative issues under the framework of characteristic function games...... and stability of international fisheries agreements. A key message that emerges from this literature strand is that self-enforcing cooperative management of internationally shared fish stocks is generally difficult to achieve. Hence, the international legal framework and regulations play a decisive role...

  4. Cancer from internal emitters

    International Nuclear Information System (INIS)

    Boecker, B.B.; Griffith, W.C. Jr.

    1995-01-01

    Irradiation from internal emitters, or internally deposited radionuclides, is an important component of radiation exposures encountered in the workplace, home, or general environment. Long-term studies of human populations exposed to various internal emitters by different routes of exposure are producing critical information for the protection of workers and members of the general public. The purpose of this report is to examine recent developments and discuss their potential importance for understanding lifetime cancer risks from internal emitters. The major populations of persons being studied for lifetime health effects from internally deposited radionuclides are well known: Lung cancer in underground miners who inhaled Rn progeny, liver cancer from persons injected with the Th-containing radiographic contrast medium Thorotrast, bone cancer from occupational or medical intakes of 226 Ra or medical injections of 224 Ra, and thyroid cancer from exposures to iodine radionuclides in the environment or for medical purposes

  5. Immunity of international organizations

    CERN Document Server

    Schrijver, Nico

    2015-01-01

    Immunity rules are part and parcel of the law of international organizations. It has long been accepted that international organizations and their staff need to enjoy immunity from the jurisdiction of national courts. However, it is the application of these rules in practice that increasingly causes controversy. Claims against international organizations are brought before national courts by those who allegedly suffer from their activities. These can be both natural and legal persons such as companies. National courts, in particular lower courts, have often been less willing to recognize the immunity of the organization concerned than the organization s founding fathers. Likewise, public opinion and legal writings frequently criticize international organizations for invoking their immunity and for the lack of adequate means of redress for claimants. It is against this background that an international conference was organized at Leiden University in June 2013. A number of highly qualified academics and practit...

  6. Attracting International Hotels

    DEFF Research Database (Denmark)

    Assaf, A. George; Josiassen, Alexander; Agbola, Frank Wogbe

    2015-01-01

    With the increased international competition facing hotel chains, it is essential that the next destination they enter is the most attractive option possible. The host destinations too have a keen interest in strategically positioning themselves in order to attract international hotels since...... their presence has several positive effects. Using, for the first time, actual on-location data we investigate the factors that matter most for international hotels when selecting host destinations. Specifically, we identify 23 factors that make a destination an attractive (or unattractive) location...... for international hotels. We then rank these. The results show that welcomeness, infrastructure, and crime rate are the three most important factors that influence the location of international hotels in host destinations....

  7. FINANCING OF INTERNATIONAL TRANSACTIONS

    Directory of Open Access Journals (Sweden)

    RADU NICOLAE BĂLUNĂ

    2013-02-01

    Full Text Available Financing (funding is essentially the purchase of funds necessary for a business. This can be done from internal sources (company’s own funds or external (borrowed funds. The high value of goods traded in international trade makes revenues generated from internal resources not sufficient to settle the value of the goods. Thus, it is frequent to resort to borrowed funds. In International Business Transactions, external financing is done both by classical techniques of credit (credit supplier and buyer credit and modern techniques of financing (factoring, forfeiting, leasing all trade tailored. In terms of the length of financing, accounting funding is short-term (1-12 months and long-term financing (over a year. In principle, export and import operations prevailing short-term financing techniques, while international investment and industrial cooperation actions are specific long-term funding

  8. Internal pump monitoring device

    International Nuclear Information System (INIS)

    Kurosaki, Toshikazu.

    1996-01-01

    In the present invention, a thermometer is disposed at the upper end of an internal pump casing of a coolant recycling system in a BWR type reactor to detect leakage of reactor water thereby ensuring the improvement of reliability of the internal pump. Namely, a thermometer is disposed, which can detect temperature elevation occurred when water in the internal pump leaked from a reactor pressure vessel passes through the gap between a stretch tube and an upper end of the pump casing. Signals from the thermometer are transmitted to a signal processing device by an instrumentation cable. The signal processing device generates an alarm when the temperature signal exceeds a predetermined value and announces that leakage of reactor water occurs in the internal pump. Since the present invention can detect the leakage of the reactor water in the pump casing in an early stage, it can contribute to the improvement of the safety and reliability of the internal pump. (I.S.)

  9. Internal Social Media

    DEFF Research Database (Denmark)

    Madsen, Vibeke Thøis

    2018-01-01

    Internal social media is a web-based communication arena that provides all organizational members with a communication opportunity. The media has emerged in organizations since 2004, and is increasingly seen as a way of giving employees a voice in organizations which can benefit the organization...... in terms of knowledge sharing, collaboration, and employee participation and engagement. The first wave of studies of internal social media was primarily from an information-systems perspective and focused more on its adoption, its affordances, and the outcome of its introduction. The second wave...... of studies was more concerned with studying the dynamics of communication on internal social media, in order to understand coworkers as strategic communicators and how communication on internal social media can constitute the organization. With a successful introduction of internal social media, coworkers...

  10. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, M. A. H.

    2014-08-05

    Internal multiples deteriorate the image when the imaging procedure assumes only single scattering, especially if the velocity model does not have sharp contrasts to reproduce such scattering in the Green’s function through forward modeling. If properly imaged, internal multiples (internally scattered energy) can enhance the seismic image. Conventionally, to image internal multiples, accurate, sharp contrasts in the velocity model are required to construct a Green’s function with all the scattered energy. As an alternative, we have developed a generalized internal multiple imaging procedure that images any order internal scattering using the background Green’s function (from the surface to each image point), constructed from a smooth velocity model, usually used for conventional imaging. For the first-order internal multiples, the approach consisted of three steps, in which we first back propagated the recorded surface seismic data using the background Green’s function, then crosscorrelated the back-propagated data with the recorded data, and finally crosscorrelated the result with the original background Green’s function. This procedure images the contribution of the recorded first-order internal multiples, and it is almost free of the single-scattering recorded energy. The cost includes one additional crosscorrelation over the conventional single-scattering imaging application. We generalized this method to image internal multiples of any order separately. The resulting images can be added to the conventional single-scattering image, obtained, e.g., from Kirchhoff or reverse-time migration, to enhance the image. Application to synthetic data with reflectors illuminated by multiple scattering (double scattering) demonstrated the effectiveness of the approach.

  11. SME International Business Models

    DEFF Research Database (Denmark)

    Child, John; Hsieh, Linda; Elbanna, Said

    2017-01-01

    This paper addresses two questions through a study of 180 SMEs located in contrasting industry and home country contexts. First, which business models for international markets prevail among SMEs and do they configure into different types? Second, which factors predict the international business...... models that SMEs follow? Three distinct international business models (traditional market-adaptive, technology exploiter, and ambidextrous explorer) are found among the SMEs studied. The likelihood of SMEs adopting one business model rather than another is to a high degree predictable with reference...

  12. International overcommitment draws warning

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    This paper reports that after rushing to take advantage of new opportunities offered by governments around the world, the international petroleum industry may be overcommitted. Cooperation among countries and companies in the next 2 years will be required if a lot of grief is to be avoided, says an international petroleum financing consultant. To respond adequately to the cash crisis, industry must: reduce internal costs; reduce project costs; lay off project obligations; sell noncore assets; renegotiate license obligations; and slow down, scale down projects; and finance projects

  13. The international development challenge

    International Nuclear Information System (INIS)

    Anon.

    1998-01-01

    Markets are opening up to international competition and new opportunities will arise for companies. The first part of this international round table of the French gas association's annual conference was devoted to whether they have all necessary assets, especially in terms of know-how and new technologies. In the second part of this round table, gas industry leaders presented their ambitions and strategies on the international scene. The questions discussed related to the main areas of development from both business and geographic viewpoints; to the underlying factors such as expertise, technological know-how, market risks and potential, strategic alliances. (authors)

  14. International energy annual 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The International Energy Annual presents an overview of key international energy trends for production, consumption, imports, and exports of primary energy commodities in over 220 countries, dependencies, and areas of special sovereignty. Also included are population and gross domestic product data, as well as prices for crude oil and petroleum products in selected countries. Renewable energy reported in the International Energy Annual includes hydroelectric power, geothermal, solar, and wind electric power, biofuels energy for the US, and biofuels electric power for Brazil. New in the 1996 edition are estimates of carbon dioxide emissions from the consumption of petroleum and coal, and the consumption and flaring of natural gas. 72 tabs.

  15. International petroleum statistics report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    The International Petroleum Statistics Report is a monthly publication that provides current international oil data. This report presents data on international oil production, demand, imports, exports and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). Section 2 presents an oil supply/demand balance for the world, in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries.

  16. Internal fuel pin oxidizer

    International Nuclear Information System (INIS)

    Andrews, M.G.

    1978-01-01

    A nuclear fuel pin has positioned within it material which will decompose to release an oxidizing agent which will react with the cladding of the pin and form a protective oxide film on the internal surface of the cladding

  17. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, M. A. H.; Alkhalifah, Tariq Ali

    2014-01-01

    Internal multiples deteriorate the image when the imaging procedure assumes only single scattering, especially if the velocity model does not have sharp contrasts to reproduce such scattering in the Green’s function through forward modeling

  18. DRI internal Wave Simulations

    National Research Council Canada - National Science Library

    Reynolds, Stephen A; Levine, Murray D

    2005-01-01

    .... A processing module is developed that takes profile estimates as input and uses numerically simulated linear internal wave displacements to create two-dimensional range-dependent sound speed fields...

  19. Globalisation of international health.

    Science.gov (United States)

    Walt, G

    1998-02-07

    40 years ago, activities in international health were the domain of WHO, governments (based on bilateral agreements), and non-governmental organisations. This has changed. Today, new players (such as the World Bank and, increasingly, the World Trade Organisation) have an influence on international health. As globalisation of trade and markets takes hold, new coalitions and alliances are forming to examine and deal with the direct and indirect consequences on health. This paper examines the changing context of cooperation in international health, and voices concerns about rising potential inequalities in health, both within and between countries. The question of how such changes will affect the actions of organisations working in international health is also addressed.

  20. International New Venture Legitimation

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2013-01-01

    the process of their emergence. It is a longitudinal, multiple-case study research that employs critical incident technique for data collection, analysis and interpretation. Following theory driven sampling, five international new ventures were selected that were operating in the software sector in the UK......There is limited theoretical understanding and empirical evidence for how international new ventures legitimate. Drawing from legitimation theory, this study fills in this gap by exploring how international new ventures legitimate and strive for survival in the face of critical events during......, and had internationalized and struggled for survival during the dotcom era. Grounded in data, this study corroborates a number of legitimation strategies yielded by prior research and refutes others. It further contributes to our understanding of international new venture legitimation by suggesting new...

  1. International Perspectives on Fieldcourses.

    Science.gov (United States)

    Nairn, Karen; Higgitt, David; Vanneste, Dominique

    2000-01-01

    Considers the context of internationalism for the enhancement of fieldwork practices. Discusses whether fieldcourses are valuable experiences. Addresses specific issues affecting internationalisation of fieldcourses, such as financial considerations, sharing courses (staff and resources), overseas fieldtrips and expeditions, safety, and student…

  2. ASKME Enterprise Portal (internal) -

    Data.gov (United States)

    Department of Transportation — The ASKME Enterprise Portal Internal (AEPi) is envisioned to be an integrated, single-point-of-entry solution that contains modular components. The AEPi will provide...

  3. International Student Mental Health

    Science.gov (United States)

    Prieto-Welch, Susan L.

    2016-01-01

    This chapter describes the mental health status of international students in institutions of higher education, unique challenges these students face and their impact on mental health, and suggestions for ways to address these challenges.

  4. NCEP Internal Office Notes

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Centers for Environmental Prediction (NCEP) and its predecessors have produced internal publications, known as Office Notes, since the mid-1950's. In...

  5. Internal radioactive contamination treatment

    International Nuclear Information System (INIS)

    Tobajas, L. M.

    1998-01-01

    In a radiological emergency, the internal radioactive contamination becomes a therapeutic urgency and must be established as fast as possible. Just when a radioactive contamination accident occurs, it is difficult to know exactly the amount of radioactive materials absorbed and to estimate the dose received.. The decision to be taken after the incorporation of the radioactive material depends on the method and on the Radiological Protection Department collaboration. Any treatment achieving a reduction of the doses received or expected will be useful. The International Radiological Protection Commission doesn't recommend the use of the dose limit, to decide about the intervention necessity. However the LIA can be used as the reference point to establish the necessity and reach of the treatment. The object of the present work, is to introduce the general principles to carry out the internal people decontamination, under the last international recommendations. (Author) 4 refs

  6. International Spinal Cord Injury

    DEFF Research Database (Denmark)

    Dvorak, M F; Itshayek, E; Fehlings, M G

    2015-01-01

    STUDY DESIGN: Survey of expert opinion, feedback and final consensus. OBJECTIVE: To describe the development and the variables included in the International Spinal Cord Injury (SCI) Spinal Interventions and Surgical Procedures Basic Data set. SETTING: International working group. METHODS......: A committee of experts was established to select and define data elements. The data set was then disseminated to the appropriate committees and organizations for comments. All suggested revisions were considered and both the International Spinal Cord Society and the American Spinal Injury Association endorsed...... spinal intervention and procedure is coded (variables 1 through 7) and the spinal segment level is described (variables 8 and 9). Sample clinical cases were developed to illustrate how to complete it. CONCLUSION: The International SCI Spinal Interventions and Surgical Procedures Basic Data Set...

  7. International SSAC training courses

    International Nuclear Information System (INIS)

    Bates, O.G.

    1985-01-01

    A speech is presented on the International Atomic Energy Agency State Systems of Accounting for and Control (SSAC) of Nuclear Materials. Two lists of countries participating in these courses are provided

  8. Seventh International Beaver Symposium

    OpenAIRE

    Yuri A. Gorshkov

    2016-01-01

    The paper presents data on the seventh international Beaver Symposium. Brief historical background about previous Beaver Symposia beaver is shown. Data on the sections of symposium, number of participants and reports are presented.

  9. Seventh International Beaver Symposium

    Directory of Open Access Journals (Sweden)

    Yuri A. Gorshkov

    2016-05-01

    Full Text Available The paper presents data on the seventh international Beaver Symposium. Brief historical background about previous Beaver Symposia beaver is shown. Data on the sections of symposium, number of participants and reports are presented.

  10. International Lymphoma Epidemiology Consortium

    Science.gov (United States)

    The InterLymph Consortium, or formally the International Consortium of Investigators Working on Non-Hodgkin's Lymphoma Epidemiologic Studies, is an open scientific forum for epidemiologic research in non-Hodgkin's lymphoma.

  11. International experience of microcredit

    OpenAIRE

    Nazarenko, M.; Nazarenko, O.

    2014-01-01

    The authors analyze international experience of microcredit development and made appropriate conclusions about the advantages and disadvantages of microcredit organization. Microcredit organizations are self-sufficient and stable institutions which are regulated by bank and state legislation.

  12. International petroleum statistics report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    This report presents data on international oil production, demand, imports, exports, and stocks. World oil production and OECD demand data are for the years 1970 through 1994; OECD stocks from 1973 through 1994; and OECD trade from 1984 through 1994.

  13. International user studies

    DEFF Research Database (Denmark)

    Nielsen, Lene; Madsen, Sabine; Jensen, Iben

    In this report, we present the results of a research project about international user studies. The project has been carried out by researchers from the Center for Persona Research and –Application, The IT University in Copenhagen and the Department of Learning and Philosophy, Aalborg University...... in Sydhavnen, and it is funded by InfinIT. Based on a qualitative interview study with 15 user researchers from 11 different companies, we have investigated how companies collect and present data about users on international markets. Key findings are: Companies do not collect data about end users in all...... the countries/regions they operate in. Instead, they focus on a few strategic markets. International user studies tend to be large-scale studies that involve the effort of many both internal and external/local human resources. The studies typically cover 2-4 countries/regions and many end users in each country...

  14. INTERNAL AUDIT CHARTER

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sandra Blanchard

    2013-03-26

    Mar 26, 2013 ... ... conduct internal audits to assess that the corporation's accounts and records; financial and management controls; information systems and management .... o Information for decision making is accurate, relevant and timely; ...

  15. International OCD Foundation

    Science.gov (United States)

    ... and productive lives. Join Donate Volunteer Events International OCD Foundation Research. Resources. Respect. About OCD About IOCDF ... Donate Here Why Should You Attend the Annual OCD Conference? Watch the Video Find Help Search the ...

  16. Risk in International Business

    OpenAIRE

    Canavan, Deirdre; Sharkey Scott, Pamela

    2012-01-01

    Risk in international business can stress risk adverse behaviour to counteract foreign market uncertainty or individual entrepreneurial risk taking behaviour dependent on the characteristics of both the business sector and the individual. International business theory would suggest that the perception of risk may differ in situations including where new market entry is incremental, is taken in larger or earlier stages, or indeed whether it may be experienced in a continually fluctuating manne...

  17. International Real Business Cycles

    OpenAIRE

    Mario J. Crucini

    2006-01-01

    This paper is a non-technical review of research developments in the international real business cycle literature. International business cycle facts are summarize with particular attention to the sources of output variance from the expenditure side of the NIPA and the production side, using a familiar neoclassical production function. Theoretical developments focus on the how consumption smoothing and investment dynamics shape the current account; the search for sources and propagation mecha...

  18. International Engagement Strategy

    Science.gov (United States)

    2017-06-14

    agreements and issue legal guidance on international law and intellectual property issues. ICPO will play an important role in realizing this vision and...the U.S. and its partners. INTERNATIONAL ENGAGEMENT VISION The directorate’s vision is for global S&T engagements to take advantage of emerging ideas...reduce risk to U.S. and partner countries, and increase their resilience; and Establish enduring relationships to provide access to

  19. Internal Control Organization Procedure

    OpenAIRE

    Radu Dorin Lenghel

    2013-01-01

    Internal control represents the totality of policies and procedures adopted by management, which contribute: to the fulfilment of managerial objectives, to the prevention and detection of frauds or errors, to the accuracy and exhaustiveness of accounting entries, as well as to the preparation in due course of financial accounting information. Internal control represents a managerial instrument which assures the fulfilment of objectives of the entity, being an ongoing process in which administ...

  20. Internal budget control

    OpenAIRE

    MSc. Mervete Shala

    2011-01-01

    Internal control is established by the Government to ensure effective and proper operations of ministries, institutions and generally of all public agencies, in compliance with the law, the goals and objectives stated by them, to provide protection against abuse and mismanagement or poor governance. The instrument of internal audit entails a series of mechanisms which aim at enabling budgetary policies compliance, such as: financial reporting; effective system of communication between mana...

  1. Performance and Internal Control

    OpenAIRE

    Mifti, Sri; Lestariyo, Nugroho Budi; Kowanda, Anacostia

    2009-01-01

    The objective of this study is to measure the influence of internal auditing on performance. Research object is Inspectorate General Department of Home Affairs staffs. As research instrument, questionnaire was developed and distributed to respondents. Closed type questionnaire was developed with five (5) choices to measure the two (2) research variables. Internal auditing is measured using six (6) dimensions, and performance is measured using three (3) dimensions. As the two variables are lat...

  2. International trade and inequality

    OpenAIRE

    Urata, Sh¯ujir¯o; Narjoko, Dionisius A.

    2017-01-01

    The impact of globalization on equality has become a serious concern for many countries. More evidence that challenges the theoretical prediction of positive impact of international trade on income distribution has increasingly become available recently. This paper addresses this subject, surveying the empirical findings on the impact of international trade on inequalities from various perspectives. The survey reveals that an increase in trade openness by developing countries appears to have ...

  3. International energy outlook, 1993

    International Nuclear Information System (INIS)

    1993-01-01

    This report presents the current Energy Information Administration (EIA) assessment of the long-term outlook for international energy markets. This and other EIA reports are provided as a statistical service for use by managers and international energy analysts, not as a Government energy plan. Current US Government policies and foreign government policies are assumed to hold over the projection interval, which extends to the year 2010

  4. International Drug Control Policy

    Science.gov (United States)

    2009-08-24

    Common illegal drugs include cannabis, cocaine, opiates, and synthetic drugs. International trade in these drugs represents a lucrative and what...into effect, decriminalizing “personal use” amounts of marijuana , heroin, cocaine, methamphetamine, and other internationally sanctioned drugs.15 While...President Calls for Legalizing Marijuana ,”CNN.com, May 13, 2009. 15 “Mexico Legalizes Drug Possession,” Associated Press, August 21, 2009. 16 In support

  5. Marketing CANDU internationally

    International Nuclear Information System (INIS)

    Langstaff, J.H.

    1980-06-01

    The market for CANDU reactor sales, both international and domestic, is reviewed. It is reasonable to expect that between five and ten reactors can be sold outside Canada before the end of the centry, and new domestic orders should be forthcoming as well. AECL International has been created to market CANDU, and is working together with the Canadian nuclear industry to promote the reactor and to assemble an attractive package that can be offered abroad. (L.L.)

  6. International petroleum statistics report

    Energy Technology Data Exchange (ETDEWEB)

    1994-05-01

    This monthly publication provides current international oil data. The Report presents data on international oil production, demand, imports, exports, and stocks. Section 1 contains time series data on world oil production, and on oil demand and stocks in the OECD. Section 2 presents an oil supply/demand balance for the world. Section 3 presents data on oil imports by OECD countries. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries.

  7. International Commercial Arbitration

    OpenAIRE

    Hlušička, Ondřej

    2011-01-01

    The purpose of my thesis is to analyse one of the most used type of extrajudicial procedures, the International commercial arbitration. The reason for my research is the progress and elevation of use of the arbitration and not only on international field. The thesis is composed of six chapters, each of them dealing with different aspects of Arbitration. Chapter One is introductory and defines basic terminology used in the thesis. The chapter is subdivided into two parts. Part One describes in...

  8. International Trade Students’ Stereotypes

    OpenAIRE

    Kamila Matysová

    2017-01-01

    The goal of the present paper is to detect stereotypes of students studying International Trade at the University of Economics Prague and, if need be, propose didactic measures for intercultural education at the university. In our study, 293 International Trade students described six ethnic and national groups (Roma, Ukrainians, Vietnamese, Russians, Germans and Czechs) in terms of explicit stereotypes. The following hypothesis was formulated in the study: On the one hand, stereotypes of the ...

  9. The international nuclear technology

    International Nuclear Information System (INIS)

    Remick, F.J.

    1992-01-01

    With today's technology, isolationism is virtually impossible. The world's economies are so strongly intertwined that what affects one country will, in some way, influence another. Nuclear technology is no exception. If anything, nuclear technology is a catalyst for international cooperation. In the United States of America, nuclear technology is undergoing significant changes. Many of these changes are being greatly influenced by programs of international cooperation

  10. International Space Station exhibit

    Science.gov (United States)

    2000-01-01

    The International Space Station (ISS) exhibit in StenniSphere at John C. Stennis Space Center in Hancock County, Miss., gives visitors an up-close look at the largest international peacetime project in history. Step inside a module of the ISS and glimpse how astronauts will live and work in space. Currently, 16 countries contribute resources and hardware to the ISS. When complete, the orbiting research facility will be larger than a football field.

  11. International Organizations and Trade

    OpenAIRE

    Antras, Pol

    2010-01-01

    The three central primitives of international trade theory are consumer preferences, factor endowments, and the production technologies that allow firms to transform factors of production into consumer goods. A limitation of traditional trade theory, however, is that the specification of technology treats the mapping between factors of production and final goods as a black box. In practice, the decisions of agents in organizations determine this mapping. Recently, international trade economis...

  12. International organization at war

    DEFF Research Database (Denmark)

    Schmitt, Olivier

    2017-01-01

    number of practices for their power advantage to take its full effect. The article also illustrates how looking at practices helps to explain policy decisions, such as NATO’s decision to engage in Afghanistan, the establishment of an International Security and Assistance Force (ISAF) strategy...... and the wording of policy papers. By studying a case of military diplomacy, the article contributes to the emerging scholarship aimed at bridging the gap between diplomatic studies and practice-based approaches to International Relations....

  13. [What is Internal Medicine?].

    Science.gov (United States)

    Reyes, Humberto

    2006-10-01

    Internal Medicine can be defined as a medical specialty devoted to the comprehensive care of adult patients, focused in the diagnosis and non surgical treatment of diseases affecting internal organs and systems (excluding gyneco-obstetrical problems) and the prevention of those diseases. This position paper reviews the history of Internal Medicine, the birth of its subspecialties and the difficulties faced by young physicians when they decide whether to practice as internist or in a subspecialty. In Chile as in most occidental countries formal training in a subspecialty of internal medicine requires previous certification in internal medicine but the proportion of young physicians who remain in practice as general internists appears to be considerably lower than those who choose a subspecialty. The main reasons for this unbalance can be related to financial advantages (by the practice of specialized technologies) and the patients' tendency to request direct assistance by a professional thought to be better qualified to take care of their specific problems. Training programs in internal medicine should consider a greater emphasis in comprehensive outpatient care instead of the traditional emphasis for training in hospital wards.

  14. International oil law

    International Nuclear Information System (INIS)

    Torkzad, B.

    1997-01-01

    The 1973 energy crisis demonstrated that the international petroleum industry is not totally free. Very often it has been the object of an organization, even during the domination of international oil companies which have established a petroleum international system with a system of concession rights. This system is based on an oligopolistic structure which had the characteristics of a monopoly. This vertically integrated structure of the world petroleum industry during the 1920-1950 era was more or less locked up by the system of concessions. The incompatibility of this system of excessively long concession contracts with the economical development needs of oil exporting countries has led to their abolishment. They have been replaced by new agreements. As soon as the creation of stable and permanent international oil organizations (OPEC, OAPEC, IEA), an institutional right has been established which has generated international rights and principles governing the contractual relations between oil exporting and oil importing countries. This international petroleum right is both original and specific, it is evolutive, contractual and normative. (J.S.)

  15. International opportunities and value creation in international entrepreneurship.

    NARCIS (Netherlands)

    Mainela, Tuija; Puhakka, Vesa; Wakkee, Ingrid; Marinova, Svetla; Larimo, Jorma; Nummela, Niina

    2016-01-01

    International entrepreneurship (IE) as a field of research has emerged at the intersection of internationalization and entrepreneurship theories. At this intersection it has come to emphasize the activities centered on international opportunities. International opportunities, then, are about value

  16. International Scientific and Technical Organisations

    International Nuclear Information System (INIS)

    Nunez-Lagos Rogla, R.

    2003-01-01

    The nuclear scientific and technical world is well aware of the EURATOM and IAEA activities but usually other international scientific and technical organisations relevant for their ordinary work are unknown. In this article three international organisations are described briefly, the International Union of Pure and Applied Physics (IUPAP). International Union of Pure and Applied chemistry (IUPAC) and the international council of Science (ICSU). (Author)

  17. Managerial Attention in International SMEs

    NARCIS (Netherlands)

    Fan, Jiasi

    2017-01-01

    Managerial attention affects organizational strategies and the resulting consequences. In the international business context, it is noted that how much attention managers give to the international marketplace, i.e., international attention, has profound implications for large global companies’

  18. Internal targets for LEAR

    International Nuclear Information System (INIS)

    Kilian, K.; Gspann, J.; Mohl, D.; Poth, H.

    1984-01-01

    This chapter considers the use of thin internal targets in conjunction with phase-space cooling at the Low-Energy Antiproton Ring (LEAR). Topics considered include the merits of internal target operation; the most efficient use of antiprotons and of proton synchrotron (PS) protons, highest center-of-mass (c.m.) energy resolution; highest angular resolution and access to extreme angles; the transparent environment for all reaction products; a windowless source and pure targets; highest luminosity and count rates; access to lowest energies with increasing resolution; internal target thickness and vacuum requirements; required cooling performance; and modes of operation. It is demonstrated that an internal target in conjunction with phase-space cooling has the potential of better performance in terms of the economic use of antiprotons and consequently of PS protons; energy resolution; angular resolution; maximum reaction rate capability (statistical precision); efficient parasitic operation; transparency of the target for reaction products; access to low energies; and the ease of polarized target experiments. It is concluded that all p - experiments which need high statistics and high p - flux, such as studies of rare channels or broad, weak resonance structures, would profit from internal targets

  19. 78 FR 18321 - International Code Council: The Update Process for the International Codes and Standards

    Science.gov (United States)

    2013-03-26

    ... Energy Conservation Code. International Existing Building Code. International Fire Code. International... Code. International Property Maintenance Code. International Residential Code. International Swimming Pool and Spa Code International Wildland-Urban Interface Code. International Zoning Code. ICC Standards...

  20. International Thermonuclear Experimental Reactor

    International Nuclear Information System (INIS)

    Blevins, J.D.; Stasko, R.R.

    1989-09-01

    An international design team comprised of members from Canada, Europe, Japan, the Soviet Union, and the United States of America, are designing an experimental fusion test reactor. The engineering and testing objectives of this International Thermonuclear Experimental Reactor (ITER) are to validate the design and to demonstrate controlled ignition, extended burn of a deuterium and tritium plasma, and achieve steady state using technology expected to be available by 1990. The concept maximizes flexibility while allowing for a variety of plasma configurations and operating scenarios. During physics phase operation, the machine produces a 22 MA plasma current. In the technology phase, the machine can be reconfigured with a thicker shield and a breeding blanket to operate with an 18 MA plasma current at a major radius of 5.5 meters. Canada's involvement in the areas of safety, facility design, reactor configuration and maintenance builds on our internationally recognized design and operational expertise in developing tritium processes and CANDU related technologies

  1. International oil opportunities

    International Nuclear Information System (INIS)

    Hares, T.N.D.; Mann, D.W.

    1995-01-01

    Some of the key issues to be addressed when selecting international opportunities, were discussed. The ideal opportunity should have the following characteristics: (1) large, low risk (2) high percentage of rent available to the investor, (3) low cost and low technical requirements, (4) low country risk, (5) low competition, (6) easy to access, and (7) favorable environment in which to work. Entering an international opportunity can be achieved by competitive bidding, direct negotiation, partnership, corporate and/or asset acquisition, and long-term relationships. Key success factors were identified as (1) applying technical financial and commercial skills in the international environment, (2) speedy response, (3) excellent relationships in the foreign country, (4) understanding the local culture, and (5) keeping a good track record. 6 figs

  2. International power opportunities

    International Nuclear Information System (INIS)

    Moon, A.

    1995-01-01

    Key factors in international development were discussed, using TransAlta Energy Corporation as an example. Trans-Alta is a company generating 4,500 MW of electricity from coal, hydro and natural gas. It has operating facilities in Canada, Argentina and New Zealand, including extensive coal mining interests in Canada. The climate for international opportunities in the energy field were judged to be very good in view of the projected requirement for some 900,000 MW of new power generation in different parts of the world by the year 2003. The five key factors identified for international power development were: (1) using core skills to add value, (2) have a long-term focus, (3) focus on specific countries and selected regions, (4) develop strong relationships with local partners, and (5) develop appropriate projects. 2 figs

  3. The International Space University

    Science.gov (United States)

    Davidian, Kenneth J.

    1990-01-01

    The International Space University (ISU) was founded on the premise that any major space program in the future would require international cooperation as a necessary first step toward its successful completion. ISU is devoted to being a leading center for educating future authorities in the world space industry. ISU's background, goals, current form, and future plans are described. The results and benefits of the type of education and experience gained from ISU include technical reports describing the design projects undertaken by the students, an exposure to the many different disciplines which are a part of a large space project, an awareness of the existing activities from around the world in the space community, and an international professional network which spans all aspects of space activities and covers the globe.

  4. International cooperative information systems

    International Nuclear Information System (INIS)

    1980-01-01

    Developing countries need mechanisms by which the information they generate themselves and development information from the rest of the world can be retrieved. The international cooperative information system is such a mechanism. Delegates to the Seminar on International Cooperative Information Systems were informed about various existing systems (INIS, AGRIS, INFOTERRA, TCDC/INRES, POPIN, DEVSIS, and INPADROC), some specialized information systems and services (CDS/ISIS and the Cassava Information Centre), and computer programs for information processing (INIS/AGRIS, CDS/ISIS, and MINISIS). The participants suggested some changes that should be made on both the national and the international levels to ensure that these systems meet the needs of developing countries more effectively. (LL)

  5. Developing International Personas

    DEFF Research Database (Denmark)

    Jensen, Iben; Hautopp, Heidi; Nielsen, Lene

    2017-01-01

    Personas have become a popular method in new product development. Personas have traditionally, and are still, primarily created to represent users from a single national culture at a time during the design process. This, however, is unsatisfactory for companies operating on a global market...... as they show an increasing interest in international personas. However, research on personas in a global context is limited. To address this gap, this paper provides an overview of extant research on international personas. Secondly, it presents an empirical study on challenges Danish IT companies experience...... when using the persona method to collect and present insights about their international users. A key finding in both the literature review and the empirical study was the ambiguity concerning the concept of culture. Therefore, the paper draws on theories about culture, and especially practice theory...

  6. Assessment of internal doses

    CERN Document Server

    Rahola, T; Falk, R; Isaksson, M; Skuterud, L

    2002-01-01

    There is a definite need for training in dose calculation. Our first course was successful and was followed by a second, both courses were fully booked. An example of new tools for software products for bioassay analysis and internal dose assessment is the Integrated Modules for Bioassay Analysis (IMBA) were demonstrated at the second course. This suite of quality assured code modules have been adopted in the UK as the standard for regulatory assessment purposes. The intercomparison measurements are an important part of the Quality Assurance work. In what is known as the sup O utside workers ' directive it is stated that the internal dose measurements shall be included in the European Unions supervision system for radiation protection. The emergency preparedness regarding internal contamination was much improved by the training with and calibration of handheld instruments from participants' laboratories. More improvement will be gained with the handbook giving practical instructions on what to do in case of e...

  7. Internal Markets for Innovation

    DEFF Research Database (Denmark)

    Wolfram, Pierre; Brem, Alexander

    2014-01-01

    of R&D to affiliated companies in the same business group. The challenges are analysed for affiliates in order to engage themselves in group-internal markets, for instance to avoid bottlenecks in the product development or to improve their technological knowledge. To research this phenomenon, a case...... study is accomplished by investigating a Multinational company whose affiliates are self-reliant and horizontally diversified. Mixed methods are applied by having structured depth interviews with the responsible R&D managers as well as by sending a survey out to associated project managers. The study...... indicates that the organizational complexity, infrastructures within the business group and the impact of external market structures play an essential role for the usage and effectiveness of group-internal markets. Hence, the insights offer valuable clues why internal markets have advantages...

  8. Internal friction in uranium

    International Nuclear Information System (INIS)

    Selle, J.E.

    1975-01-01

    Results are presented of studies conducted to relate internal friction measurements in U to allotropic transformations. It was found that several internal friction peaks occur in α-uranium whose magnitude changed drastically after annealing in the β phase. All of the allotropic transformations in uranium are diffusional in nature under slow heating and cooling conditions. Creep at regions of high stress concentration appears to be responsible for high temperature internal friction in α-uranium. The activation energy for grain boundary relaxation in α-uranium was found to be 65.1 +- 4 kcal/mole. Impurity atoms interfere with the basic mechanism for grain boundary relaxation resulting in a distribution in activation energies. A considerable distribution in ln tau 0 was also found which is a measure of the distribution in local order and in the Debye frequency around a grain boundary

  9. International energy annual 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-04-01

    The International Energy Annual presents an overview of key international energy trends for production, consumption, imports, and exports of primary energy commodities in over 220 countries, dependencies, and areas of special sovereignty. Also included are population and gross domestic product data, as well as prices for crude oil and petroleum products in selected countries. Renewable energy reported in the International Energy Annual includes hydroelectric power and geothermal, solar, and wind electric power. Also included are biomass electric power for Brazil and the US, and biomass, geothermal, and solar energy produced in the US and not used for electricity generation. This report is published to keep the public and other interested parties fully informed of primary energy supplies on a global basis. The data presented have been largely derived from published sources. The data have been converted to units of measurement and thermal values (Appendices E and F) familiar to the American public. 93 tabs.

  10. International Data & Economic Analysis (IDEA)

    Data.gov (United States)

    US Agency for International Development — International Data UN Food and Agriculture Organization, Food Price Index; IMF, Direction of Trade Statistics; Millennium Challenge Corporation; and World Bank,...

  11. International Journal of Health Research

    African Journals Online (AJOL)

    Erah

    The International Journal of Health Research is an online international journal ... disciplines (including medicine, pharmacy, nursing, biotechnology, cell and ... collaboration among scientists, the industry and the healthcare professionals.

  12. ILO - International Migration Programme.

    Science.gov (United States)

    Boudraa, Miriam

    2011-01-01

    In a wide International Context characterised not only by the economical development but also by the social, cultural, political and individual development, we witness more and more to a exchange between the developed and the developing countries, which can be translated especially in the migration of the work force. In theory, all countries are either countries of origin either countries of transit or destination, and they are all responsible for the rights of migrant workers by promoting the rights, by monitoring and by preventing the abusive conditions. The process of migration of the workforce can be divided into three stages: the first coincides with the period prior to departure, the second is represented by the aftermath of the departure and the period of stay in the country of destination, the third stage corresponds to the return in the country of origin. The workers must be protected throughout this process by the international organizations that perform the catalytic role of communication and exchange between countries, for the only purpose of protecting the rights of immigrant and/or immigrants workers. The responsibility for the protection of workers is divided among the various players in the International Labour Organisation. Every country has to apply measures according to the international standards regarding workers' rights, standards that guide the various countries in the formulation and implementation of their policies and legislation. These standards are suggested by International Conventions, the ILO Conventions and other international instruments such as the human rights instrument. There has been a big step forward once the ILO Fundamental Conventions and Conventions on Migrant Workers where implemented and this implementation represented the use of the Guidelines "ILO Multilateral Framework on Labour Migration".

  13. Why international primacy matters

    International Nuclear Information System (INIS)

    Huntington, S.P.

    1993-01-01

    Does international primacy matter? The answer seems so obvious that one first wonders why someone as intelligent, perceptive, and knowledgeable as Robert Jervis raises the question. On further thought, however, one sees that while the answer may be obvious for most people, the reasons why it is obvious may not be all that clear and may have been forgotten or lost in the other concerns of political scientists and economists studying international relations. By posing this question at this time of change in world affairs Jervis has constructively forced us to rethink why primacy is of central importance. This issue involves several subordinate questions

  14. International Business Cycle Accounting

    OpenAIRE

    Keisuke Otsu

    2009-01-01

    In this paper, I extend the business cycle accounting method a la Chari, Kehoe and McGrattan (2007) to a two-country international business cycle model and quantify the effect of the disturbances in relevant markets on the business cycle correlation between Japan and the US over the 1980-2008 period. This paper finds that disturbances in the labor market and production efficiency are important in accounting for the recent increase in the cross-country output correlation. If international fina...

  15. Internal sources dosimetry

    International Nuclear Information System (INIS)

    Savio, Eduardo

    1994-01-01

    The absorbed dose, need of estimation in risk evaluation in the application of radiopharmaceuticals in Nuclear Medicine practice,internal dosimetry,internal and external sources. Calculation methodology,Marinelli model,MIRD system for absorbed dose calculation based on biological parameters of radiopharmaceutical in human body or individual,energy of emitted radiations by administered radionuclide, fraction of emitted energy that is absorbed by target body.Limitation of the MIRD calculation model. A explanation of Marinelli method of dosimetry calculation,β dosimetry. Y dosimetry, effective dose, calculation in organs and tissues, examples. Bibliography .

  16. International Market Analysis

    DEFF Research Database (Denmark)

    Sørensen, Olav Jull

    2009-01-01

    The review presents the book International Market Analysis: Theories and Methods, written by John Kuiada, professor at Centre of International Business, Department of Business Studies, Aalborg University. The book is refreshingly new in its way of looking at a classical problem. It looks at market...... analysis from the point of vie of ways of thinking about markets. Furthermore, the book includes the concept of learning in the analysis of markets og how the way we understand business reality influneces our choice of methodology for market analysis....

  17. International regulatory activities

    International Nuclear Information System (INIS)

    Anon.

    2009-01-01

    In this last part is reviewed international regulatory activities and bilateral agreements including two parts: concerning European atomic energy community with European commission proposal for a council directive setting up a community framework for nuclear safety, update of the nuclear illustrative programme in the context of the second strategic energy review, european commission recommendation on criteria for the export of radioactive waste and spent fuel to third countries and a communication on nuclear non-proliferation and the second part in relation with international atomic energy agency with a joint convention on the safety of spent fuel management and on safety of radioactive waste management (third review meeting). (N.C.)

  18. International regulatory activities

    International Nuclear Information System (INIS)

    Anon.

    2002-01-01

    Different international regulatory activities are presented: recommendation on the protection of the public against exposure to radon in drinking water supplies, amendment to the legislation implementing the regulation on imports of agricultural products originating in third countries following the Chernobyl accident, resolution on the commission green paper towards a European strategy for the security of energy supply, declaration of mandatory nature of the international code for the safe carriage of packaged irradiated nuclear fuel, plutonium and high level radioactive wastes on board ships, adoption of action plan against nuclear terrorism. (N.C.)

  19. Internal variables in thermoelasticity

    CERN Document Server

    Berezovski, Arkadi

    2017-01-01

    This book describes an effective method for modeling advanced materials like polymers, composite materials and biomaterials, which are, as a rule, inhomogeneous. The thermoelastic theory with internal variables presented here provides a general framework for predicting a material’s reaction to external loading. The basic physical principles provide the primary theoretical information, including the evolution equations of the internal variables. The cornerstones of this framework are the material representation of continuum mechanics, a weak nonlocality, a non-zero extra entropy flux, and a consecutive employment of the dissipation inequality. Examples of thermoelastic phenomena are provided, accompanied by detailed procedures demonstrating how to simulate them.

  20. INTERNAL ENVIRONMENT ANALYSIS TECHNIQUES

    Directory of Open Access Journals (Sweden)

    Caescu Stefan Claudiu

    2011-12-01

    Full Text Available Theme The situation analysis, as a separate component of the strategic planning, involves collecting and analysing relevant types of information on the components of the marketing environment and their evolution on the one hand and also on the organization’s resources and capabilities on the other. Objectives of the Research The main purpose of the study of the analysis techniques of the internal environment is to provide insight on those aspects that are of strategic importance to the organization. Literature Review The marketing environment consists of two distinct components, the internal environment that is made from specific variables within the organization and the external environment that is made from variables external to the organization. Although analysing the external environment is essential for corporate success, it is not enough unless it is backed by a detailed analysis of the internal environment of the organization. The internal environment includes all elements that are endogenous to the organization, which are influenced to a great extent and totally controlled by it. The study of the internal environment must answer all resource related questions, solve all resource management issues and represents the first step in drawing up the marketing strategy. Research Methodology The present paper accomplished a documentary study of the main techniques used for the analysis of the internal environment. Results The special literature emphasizes that the differences in performance from one organization to another is primarily dependant not on the differences between the fields of activity, but especially on the differences between the resources and capabilities and the ways these are capitalized on. The main methods of analysing the internal environment addressed in this paper are: the analysis of the organizational resources, the performance analysis, the value chain analysis and the functional analysis. Implications Basically such

  1. International Conference on Physics

    CERN Document Server

    2016-01-01

    OMICS International, (conference series) the World Class Open Access Publisher and Scientific Event Organizer is hosting “International Conference on physics” which is going to be the biggest conference dedicated to Physics. The theme “Highlighting innovations and challenges in the field of Physics” and it features a three day conference addressing the major breakthroughs, challenges and the solutions adopted. The conference will be held during June 27-29, 2016 at New Orleans, USA. Will be published in: http://physics.conferenceseries.com/

  2. International emissions trading

    DEFF Research Database (Denmark)

    Boom, Jan Tjeerd

    This thesis discusses the design and political acceptability of international emissions trading. It is shown that there are several designs options for emissions trading at the national level that have a different impact on output and thereby related factors such as employment and consumer prices....... The differences in impact of the design make that governments may prefer different designs of emissions trading in different situations. The thesis furthermore establishes that international emissions trading may lead to higher overall emissions, which may make it a less attractive instrument....

  3. International mineral economics

    International Nuclear Information System (INIS)

    Gocht, W.R.; Eggert, R.G.

    1988-01-01

    International Mineral Economics provides an integrated overview of the important concepts. The treatment is interdisciplinary, drawing on the fields of economics, geology, business, and mining engineering. Part I examines the technical concepts important for understanding the geology of ore deposits, the methods of exploration and deposit evaluation, and the activities of mining and mineral processing. Part II focuses on the economic and related concepts important for understanding mineral development, the evaluation of exploration and mining projects, and mineral markets and market models. Finally, Part III reviews and traces the historical development of the policies of international organizations, the industrialized countries, and the developing countries. (orig.)

  4. International Geomagnetic Reference Field

    DEFF Research Database (Denmark)

    Finlay, Chris; Maus, S.; Beggan, C. D.

    2010-01-01

    The eleventh generation of the International Geomagnetic Reference Field (IGRF) was adopted in December 2009 by the International Association of Geomagnetism and Aeronomy Working Group V‐MOD. It updates the previous IGRF generation with a definitive main field model for epoch 2005.0, a main field...... model for epoch 2010.0, and a linear predictive secular variation model for 2010.0–2015.0. In this note the equations defining the IGRF model are provided along with the spherical harmonic coefficients for the eleventh generation. Maps of the magnetic declination, inclination and total intensity...

  5. Major international sport profiles.

    Science.gov (United States)

    Patel, Dilip R; Stier, Bernhard; Luckstead, Eugene F

    2002-08-01

    Sports are part of the sociocultural fabric of all countries. Although different sports have their origins in different countries, many sports are now played worldwide. International sporting events bring athletes of many cultures together and provide the opportunity not only for athletic competition but also for sociocultural exchange and understanding among people. This article reviews five major sports with international appeal and participation: cricket, martial arts, field hockey, soccer, and tennis. For each sport, the major aspects of physiological and biomechanical demands, injuries, and prevention strategies are reviewed.

  6. International nuclear agreements

    International Nuclear Information System (INIS)

    Miatello, A.; Severino, R.

    1988-01-01

    This multilingual glossary, in the laborious compilation of which the authors have been greatly assisted by a group of professional translators and experts, presents for the first time a substantial number of entries in four languages (English, French, German and Italian), whose terminology and phraseology, all bearing the appropriate normative reference, has been drawn from the official text of the most relevant international agreements on nuclear policy. It is complemented by a thorough critical study on the status of nonproliferation by Lawrence Scheinman and Josef Pilat. Librarians, translators and interpreters as well as scholars and researchers in international law will find this volume a reference tool of specific interest

  7. Bourdieu in International Relations

    DEFF Research Database (Denmark)

    The last few years have seen a genuine wave of publications promoting sociology in international relations. Scholars have suggested that Bourdieu’s vocabulary can be applied to study security, diplomacy, migration and global environmental politics. Yet we still lack a systematic and accessible....... The chapters demonstrate how these concepts can be reinterpreted and used in new ways when exposed to Bourdieusian logic. Challenging key pillars of IR scholarship, Bourdieu in International Relations will be of interest to critical theorists, and scholars of IR theory....

  8. International co-operation

    International Nuclear Information System (INIS)

    Klinda, J.; Lieskovska, Z.

    1998-01-01

    Within the Union Nations (UN) framework, the Slovak Republic participated in following activities on environment protection co-operation: UN European Economic Commission, UN Industrial Development Organization, UN Development Programme, UN Human Habitat Organization, UN Environment Programme, and UN Commission on Sustainable Development. Relevant activities of the Slovak Republic in these co-operations as well as in European Union and OECD activities are reviewed. International conventions and other forms of multilateral co-operation, bilateral co-operation, and international programmes and projects in which the Slovak Republic took participate are presented

  9. ENSI international strategy

    International Nuclear Information System (INIS)

    2014-07-01

    This brochure issued by the Swiss Federal Nuclear Safety Inspectorate ENSI discusses ENSI’s role in international cooperation in the nuclear safety area. Questions looked at include to what degree ENSI should engage itself at an international level, especially in certain IAEA missions, which topics should be addressed, which results should be aimed for and how current scientific and technical state-of-the-art should be monitored. Strategic targets are discussed, main areas of action are examined and ENSI’s position with respect to safety, transparency, independence and competence is declared. The various implementation instances within ENSI are looked at

  10. The international RESPO network

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-01

    Winrock International, with sponsorship from the Center for Environment of the U.S. Agency for International Development (USAID) and the U.S. Export Council for Renewable Energy (US/ECRE), is building a global network of non-governmental organizations to help catalyze the use of renewable energy technologies for rural energy supply in developing countries. Known as the Renewable Energy Project Support Offices (REPSOs), these in-country facilities are managed by local institutions in coordination with Winrock. REPSOs provide an array of technical and financial support services to help developers identify and evaluate opportunities for renewable energy projects.

  11. International Youth Library

    Directory of Open Access Journals (Sweden)

    Osman Ümit Özen

    1994-03-01

    Full Text Available International Youth Library, the biggest youth library in the world, was founded in 1948 in Munich, Germany, by Jella Lepman. She aimed to unite all the children of the world through books by establishing this library. IYL is still trying to achieve this end supporting scholarship programmes in children’s literature research, participating in or organizing meetings on children’s literature, and working with other national and international organizations deeding with children’s literature. Unfortunately the library is facing some problems recently which have risen from economic difficulties which also inhibits promotional activities.

  12. International radiofrequency standards

    International Nuclear Information System (INIS)

    Lincoln, J.

    2001-01-01

    Of the various radiofrequency standards in use around the world, many are based on or similar to the Guidelines published by ICNIRP (The International Commission on Non-ionising Radiation Protection). This organisation is a working group operating in co-operation with the Environmental Health division of the World Health Organisation (WHO). This paper presents a very brief overview of current international standards, beginning with a summary of the salient points of the ICNIRP Guidelines. It should be remembered that these are guidelines only and do not exist as a separate standard. Copyright (2001) Australasian Radiation Protection Society Inc

  13. The international safeguards profession

    International Nuclear Information System (INIS)

    Sanders, K.E.

    1986-01-01

    The International Atomic Energy Agency has established a staff of safeguards professionals who are responsible for carrying out on-site inspections to determine compliance with international safeguards agreements. By IAEA Statute, the paramount consideration in recruiting IAEA staff is to secure employees of the highest standards of efficiency, technical competence, and integrity. An analysis of the distribution of professionals in the IAEA Department of Safeguards has revealed some interesting observations regarding the distribution of grade levels, age, time in service, gender, and geographical origin. Following several earlier studies performed by contractors for ACDA, U.S. efforts have been undertaken to attract and better prepare candidates for working at the IAEA

  14. Internationalism and Globalization as Contexts for International Education

    Science.gov (United States)

    Cambridge, James; Thompson, Jeff

    2004-01-01

    A problem with the construction of an inclusive definition of international education is that the word 'international' has a variety of connotations. It is proposed that the term 'international education' is ambiguous because it appears to refer to contrasting usages in educational studies. International education is frequently discussed in the…

  15. Simulation in International Studies

    Science.gov (United States)

    Boyer, Mark A.

    2011-01-01

    Social scientists have long worked to replicate real-world phenomena in their research and teaching environments. Unlike our biophysical science colleagues, we are faced with an area of study that is not governed by the laws of physics and other more predictable relationships. As a result, social scientists, and international studies scholars more…

  16. International petroleum statistics report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    The International Petroleum Statistics Report is a monthly publication that provides current international oil data. This report is published for the use of Members of Congress, Federal agencies, State agencies, industry, and the general public. Publication of this report is in keeping with responsibilities given the Energy Information Administration in Public Law 95-91. The International Petroleum Statistics Report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1995; OECD stocks from 1973 through 1995; and OECD trade from 1985 through 1995.

  17. Internal Dosimetry. Chapter 18

    Energy Technology Data Exchange (ETDEWEB)

    Hindorf, C. [Department of Radiation Physics, Skåne University Hospital, Lund (Sweden)

    2014-12-15

    The Committee on Medical Internal Radiation Dose (MIRD) is a committee within the Society of Nuclear Medicine. The MIRD Committee was formed in 1965 with the mission to standardize internal dosimetry calculations, improve the published emission data for radionuclides and enhance the data on pharmacokinetics for radiopharmaceuticals [18.1]. A unified approach to internal dosimetry was published by the MIRD Committee in 1968, MIRD Pamphlet No. 1 [18.2], which was updated several times thereafter. Currently, the most well known version is the MIRD Primer from 1991 [18.3]. The latest publication on the formalism was published in 2009 in MIRD Pamphlet No. 21 [18.4], which provides a notation meant to bridge the differences in the formalism used by the MIRD Committee and the International Commission on Radiological Protection (ICRP) [18.5]. The formalism presented in MIRD Pamphlet No. 21 [18.4] will be used here, although some references to the quantities and parameters used in the MIRD primer [18.3] will be made. All symbols, quantities and units are presented.

  18. International hearing protector standardization

    DEFF Research Database (Denmark)

    Poulsen, Torben

    2002-01-01

    Hearing protectors shall fulfill some minimum requirements to their performance. As hearing protector manufacturers sell the products all over the world, the testing and certification of hearing protectors has become an international issue. The ISO working group WG17 under the headlines Acoustics...

  19. When managerialism meets internationalism

    DEFF Research Database (Denmark)

    Dykmann, Klaas; Lewis, Jenny; Bentzen, Sune Raahede

    2014-01-01

    This article examines whether reform ideas that gained influence in national-level bureaucracies in the 1970s were also on the United Nations’ internal agenda. The Joint Inspection Unit (Bertrand) Report of 1971 is the focus of this analysis, as it addressed personnel problems in the UN Secretari...

  20. INTERNATIONAL COLLABORATION: Panelling

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    At the meeting of the International Committee for Future Accelerators (ICFA), in Geneva in July, Chairman A.N. Skrinsky of Novosibirsk reviewed ICFA progress, particularly the activities of the specialist Panels which pursue specific Committee objectives in guiding worldwide collaboration in high energy physics

  1. Cyberinfrastructure for international competitiveness

    CSIR Research Space (South Africa)

    Sithole, Happy M

    2015-10-01

    Full Text Available to international science projects such as the Large Hadron Collider at the European Organization for Nuclear Research, CERN. Benefits are being realised through efficient connectivity and decrease in the cost of bandwidth. In this presentation, Sithole will provide...

  2. Introducing International Geneva

    CERN Multimedia

    2015-01-01

    Geneva is variously known as the city of peace, the world’s smallest metropolis and a place where great ideas have taken form. It has been the home to philosophers such as Rousseau and Voltaire. It was the centre of the Calvinist reformation and birthplace of the Red Cross.   I hardly need to tell you that it is also a city of great international collaboration in science. Little wonder, then, that over the years, Geneva has developed into the world’s capital of internationalism in the broadest sense of the word. Yet while we all know of the existence of modern day International Geneva, how many of us really know what it does? Here at CERN, we’re about to find out. Next week sees the first in a series of talks at the Laboratory from the heads of some of the institutions that make up International Geneva. On Friday, 20 February, it will be my pleasure to introduce you to Michael Møller, Acting Director-General of the United Nations Office at Geneva (UNO...

  3. International energy outlook 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    This International Energy Outlook presents historical data from 1970 to 1993 and EIA`s projections of energy consumption and carbon emissions through 2015 for 6 country groups. Prospects for individual fuels are discussed. Summary tables of the IEO96 world energy consumption, oil production, and carbon emissions projections are provided in Appendix A. The reference case projections of total foreign energy consumption and of natural gas, coal, and renewable energy were prepared using EIA`s World Energy Projection System (WEPS) model. Reference case projections of foreign oil production and consumption were prepared using the International Energy Module of the National Energy Modeling System (NEMS). Nuclear consumption projections were derived from the International Nuclear Model, PC Version (PC-INM). Alternatively, nuclear capacity projections were developed using two methods: the lower reference case projections were based on analysts` knowledge of the nuclear programs in different countries; the upper reference case was generated by the World Integrated Nuclear Evaluation System (WINES)--a demand-driven model. In addition, the NEMS Coal Export Submodule (CES) was used to derive flows in international coal trade. As noted above, foreign projections of electricity demand are now projected as part of the WEPS. 64 figs., 62 tabs.

  4. International environmental agreements

    NARCIS (Netherlands)

    de Zeeuw, Aart

    2015-01-01

    The regulation of environmental externalities at the global level requires international agreements between sovereign states. Game theory provides an appropriate theoretical tool for analysis. However, game theory can result in a wide range of outcomes, and therefore it is important to discuss the

  5. Requirements for Xenon International

    Energy Technology Data Exchange (ETDEWEB)

    Hayes, James C.; Ely, James H.

    2013-09-26

    This document defines the requirements for the new Xenon International radioxenon system. The output of this project will be a Pacific Northwest National Laboratory (PNNL) developed prototype and a manufacturer-developed production prototype. The two prototypes are intended to be as close to matching as possible; this will be facilitated by overlapping development cycles and open communication between PNNL and the manufacturer.

  6. Requirements for Xenon International

    Energy Technology Data Exchange (ETDEWEB)

    Hayes, James C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ely, James H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Haas, Derek A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Harper, Warren W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Heimbigner, Tom R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hubbard, Charles W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Humble, Paul H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Madison, Jill C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Morris, Scott J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Panisko, Mark E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ripplinger, Mike D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stewart, Timothy L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-12-30

    This document defines the requirements for the new Xenon International radioxenon system. The output of this project will be a Pacific Northwest National Laboratory (PNNL) developed prototype and a manufacturer-developed production prototype. The two prototypes are intended to be as close to matching as possible; this will be facilitated by overlapping development cycles and open communication between PNNL and the manufacturer.

  7. Pathways Intern Report

    Science.gov (United States)

    Huggett, Daniel James

    2017-01-01

    The National Aeronautics and Space Administration (NASA) provides a formal training program for prospective employees titled, Pathways Intern Employment. The Pathways program targets graduate and undergraduate students who strive to become an active contributor to NASA's goal of space exploration. The report herein provides an account of Daniel Huggett's Pathways experience for the Spring and Summer 2017 semesters.

  8. Active internal corrector coils

    International Nuclear Information System (INIS)

    Thompson, P.A.; Cottingham, J.; Dahl, P.

    1986-01-01

    Trim or corrector coils to correct main magnet field errors and provide higher multipole fields for beam optics purposes are a standard feature of superconducting magnet accelerator systems. This paper describes some of the design and construction features of powered internal trim coils and a sampling of the test results obtained

  9. [Internal migration studies].

    Science.gov (United States)

    Stpiczynski, T

    1986-10-01

    Recent research on internal migration in Poland is reviewed. The basic sources of data, consisting of censuses or surveys, are first described. The author discusses the relationship between migration studies and other sectors of the national economy, and particularly the relationship between migration and income.

  10. Introduction to International Trade.

    Science.gov (United States)

    Crummett, Dan M.; Crummett, Jerrie

    This set of student and teacher guides is intended for use in a course to prepare students for entry-level employment in such occupational areas in international trade as business/finance, communications, logistics, and marketing. The following topics are covered in the course's five instructional units: introduction to careers in international…

  11. Successful international negotiations

    International Nuclear Information System (INIS)

    Gerry, G.

    1997-01-01

    These remarks on successful international trade negotiations deal with the following topics: culture and differences in psychology; building friendly relationships and letting both sides appear to win; well written proposals; security of negotiating information; the complexity and length of nuclear negotiations

  12. International Divider Walls

    NARCIS (Netherlands)

    Kruis, A.; Sneller, Lineke

    2013-01-01

    The subject of this teaching case is the Enterprise Resource Planning (ERP) system implementation at International Divider Walls, the world market leader in design, production, and sales of divider walls. The implementation in one of the divisions of this multinational company had been successful,

  13. INTERNAL AUDIT CHARTER

    International Development Research Centre (IDRC) Digital Library (Canada)

    sblanchard

    2015-03-30

    Mar 30, 2015 ... Assurance and Advice to Support Innovating for Development ... IDRC's Board of Governors approves the Internal Audit Charter which outlines the ... the principles of integrity, objectivity, confidentiality, and competency, and IDRC's Code of. Conduct and the Values and Ethics Code for the Public Service;.

  14. INTERNATIONAL COLLABORATION: Panelling

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1991-10-15

    At the meeting of the International Committee for Future Accelerators (ICFA), in Geneva in July, Chairman A.N. Skrinsky of Novosibirsk reviewed ICFA progress, particularly the activities of the specialist Panels which pursue specific Committee objectives in guiding worldwide collaboration in high energy physics.

  15. International fuel bank

    International Nuclear Information System (INIS)

    The working group discusses the establishment of an international bank for nuclear fuels. The statements by representatives of seven countries discuss the specific features of a bank of this kind which is set up to facilitate access to nuclear fuels but also to permit a more rigid control in the sense of the non-proliferation philosophy

  16. The international atom

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1962-12-31

    The film explains in basic terms nuclear fission, the use of nuclear power (propulsion of ships), the production and use of radioisotopes (medicine-radioactive tracers, sterilization of instruments; agriculture-fertilizers, screw-worm elimination, irradiation of food; industry). Demonstrates international co-operation and research in the nuclear field

  17. International fusion research council

    International Nuclear Information System (INIS)

    Belozerov, A.N.

    1977-01-01

    A brief history of the International Fusion Research Council (IFRC) is given and the minutes of the 1976 meeting in Garching are summarized. At the Garching meeting, the IFRC evaluated the quality of papers presented at recent IAEA conferences on plasma physics and controlled thermonuclear research, and made recommendations on the organization and timing of future meetings on nuclear fusion

  18. International Financial Reporting Standards

    DEFF Research Database (Denmark)

    Pontoppidan, Caroline Aggestam

    2011-01-01

    The advance of International Financial Reporting Standards (IFRS) across the globe has accelerated over the last few years. This is placing increasing demands on educators to respond to these changes by an increased focus on IFRS in the curricula of accounting students. This paper reviews a range...

  19. International energy outlook 1996

    International Nuclear Information System (INIS)

    1996-05-01

    This International Energy Outlook presents historical data from 1970 to 1993 and EIA's projections of energy consumption and carbon emissions through 2015 for 6 country groups. Prospects for individual fuels are discussed. Summary tables of the IEO96 world energy consumption, oil production, and carbon emissions projections are provided in Appendix A. The reference case projections of total foreign energy consumption and of natural gas, coal, and renewable energy were prepared using EIA's World Energy Projection System (WEPS) model. Reference case projections of foreign oil production and consumption were prepared using the International Energy Module of the National Energy Modeling System (NEMS). Nuclear consumption projections were derived from the International Nuclear Model, PC Version (PC-INM). Alternatively, nuclear capacity projections were developed using two methods: the lower reference case projections were based on analysts' knowledge of the nuclear programs in different countries; the upper reference case was generated by the World Integrated Nuclear Evaluation System (WINES)--a demand-driven model. In addition, the NEMS Coal Export Submodule (CES) was used to derive flows in international coal trade. As noted above, foreign projections of electricity demand are now projected as part of the WEPS. 64 figs., 62 tabs

  20. International thermal reactor development

    International Nuclear Information System (INIS)

    Zebroski, E.L.

    1977-01-01

    The worldwide development of nuclear power plants is reviewed. Charts are presented which show the commitment to light-water reactor capacity construction with breakdown by region and country. Additional charts show the major nuclear research centers which have substantial scope in light water reactor development and extensive international activities

  1. Direct vision internal urethrotomy

    DEFF Research Database (Denmark)

    Jakobsen, H; Willumsen, H; Søndergaard Jensen, L

    1984-01-01

    During a five-year period, direct vision internal urethrotomy was used for the treatment of urethral strictures in 34 men. After the primary operation the patients were followed for an average period of 29 months (range 3-73 months). During this period 53% of the patients were found to have one...

  2. International Students in China

    DEFF Research Database (Denmark)

    As the number of international students in Chinese higher education increases steadily, this volume is one of the first to focus on their many and varied experiences. With contributions focusing on such topics as intercultural adaptation, soft power and interculturality, language learning strateg...

  3. International institutional law

    CERN Document Server

    Schermers, Henry G

    1972-01-01

    In several respects the present study is an enlargement of a former analysis about the specialized agencies of the United Nations to more organisations and into further detail. In particular the creation of the European Communities, adding new aspects to international institutional law, have received attention.

  4. Introduction to International Trade.

    Science.gov (United States)

    Intercom, 1986

    1986-01-01

    Focusing mainly on United States-Japan relations, this issue provides 11 lesson plans and student handouts dealing with international trade topics such as protective tariffs, currency exchange rates, unofficial trade barriers, causes of unemployment, the balance of payments and the internationalization of the automobile industry. (JDH)

  5. Medications and International Travel

    Centers for Disease Control (CDC) Podcasts

    2011-04-12

    This podcast answers a listener's question about her medications and an international trip she's planning.  Created: 4/12/2011 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 4/12/2011.

  6. International nuclear law

    International Nuclear Information System (INIS)

    Mello, M.M. de.

    1981-01-01

    The peculiar feature of a developing nuclear law is discussed. Opinions from various writers and jurists are presented. It is concluded that it should be considered as international law, whose main sources are the various treaties, conventions and agreements. (A.L.) [pt

  7. International co-operation

    International Nuclear Information System (INIS)

    1998-01-01

    In this part the are reviewed: Co-operation with IAEA; Participation of the Slovakia on the 41 st session of the General Conference; The comprehensive Nuclear-Test-Ban Treaty Organization; Co-operation with the Organization for Economic Co-operation and Development; co-operation with the European Commission; Fulfillment of obligations resulting from the international contracting documents

  8. International nuclear safety

    International Nuclear Information System (INIS)

    Wolff, P.H.W.

    1978-01-01

    The background to the development of internationally agreed safety principles and practices is discussed. The activities of the IAEA and the scope, structure, and organisation of its programme of Reactor Safety Codes and Guides are described. Attention is drawn to certain areas needing further considerations. (UK)

  9. International Neutron Radiography Newsletter

    DEFF Research Database (Denmark)

    Domanus, Joseph Czeslaw

    1986-01-01

    At the First World Conference on Neutron Radiography i t was decided to continue the "Neutron Radiography Newsletter", published previously by J.P. Barton, as the "International Neutron Radiography Newsletter" (INRNL), with J.C. Doraanus as editor. The British Journal of Non-Destructive Testing...

  10. International Photovoltaic Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    Costello, D.; Koontz, R.; Posner, D.; Heiferling, P.; Carpenter, P.; Forman, S.; Perelman, L.

    1979-12-01

    The International Photovoltaics Program Plan is in direct response to the Solar Photovoltaic Energy Research, Development, and Demonstration Act of 1978 (PL 95-590). As stated in the Act, the primary objective of the plan is to accelerate the widespread use of photovoltaic systems in international markets. Benefits which could result from increased international sales by US companies include: stabilization and expansion of the US photovoltaic industry, preparing the industry for supplying future domestic needs; contribution to the economic and social advancement of developing countries; reduced world demand for oil; and improvements in the US balance of trade. The plan outlines programs for photovoltaic demonstrations, systems developments, supplier assistance, information dissemination/purchaser assistance, and an informaion clearinghouse. Each program element includes tactical objectives and summaries of approaches. A program management office will be established to coordinate and manage the program plan. Although the US Department of Energy (DOE) had the lead responsibility for preparing and implementing the plan, numerous federal organizations and agencies (US Departments of Commerce, Justice, State, Treasury; Agency for International Development; ACTION; Export/Import Bank; Federal Trade Commission; Small Business Administration) were involved in the plan's preparation and implementation.

  11. International waste management conference

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    This book contains the proceedings of the international waste management conference. Topics covered include: Quality assurance in the OCR WM program; Leading the spirit of quality; Dept. of Energy hazardous waste remedial actions program; management of hazardous waste projects; and System management and quality assurance

  12. International Chernobyl project

    International Nuclear Information System (INIS)

    1991-01-01

    The film documents the work of the radiation experts of 8 international organizations in the area around the damaged Chernobyl nuclear power plant. During this evaluation, radiation measurements and medical examinations of the population were carried out and samples of soil, water, plants and food taken

  13. International Space Law

    Directory of Open Access Journals (Sweden)

    M. Lits

    2017-01-01

    Full Text Available It is well known that the modern day technologies that drive our global society are highly dependent on the use of outer space. For example, daily activities such as sending emails, making phone calls and carrying out bank transactions cannot be done unless satellite technologies are involved. When you catch a plane, the air traffic control is dependent on GPS. Even natural disaster management is dependent on satellite imaging. Taking into account the importance of this, it becomes increasingly necessary to be knowledgeable in the field of international law as it is the only sphere of law that reaches beyond the physical boundaries of the Earth, goes deep into space and provides protection for today’s society. With new steps being taken to exploit further the potentials of outer space, and with increasing talk of new space missions and new discoveries, current international space law is being placed under scrutiny, for it should be remembered that the major international legal documents in this field were adopted in the middle of the 20th century, and thus there are fears that the law may have become obsolete, irrelevant in the face of new challenges in the use of outer space. This paper delivers an analysis of existing international space law and attempts to raise several crucial issues pertinent in the area.

  14. Developing international personas

    DEFF Research Database (Denmark)

    Jensen, Iben; Hautopp, Heidi; Nielsen, Lene

    2017-01-01

    , to discuss how challenges related to perceptions of culture and intercultural communication might be overcome when working with international personas. In particular, it is suggested that the persona method could benefit from creating narratives that focus more on the similar practices enacted...

  15. Internal dose estimates

    International Nuclear Information System (INIS)

    Wrenn, M.E.

    1977-01-01

    Internal doses, the procedures for making them and their significance has been reviewed. Effects of uranium, radium, lead-210, polonium-210, thorium in man are analysed based on data from tables and plots. Dosimetry of some ingested nuclides and inhalation dose due to radon-222, radon-220 and their daugther products are discussed [pt

  16. International co-operation

    International Nuclear Information System (INIS)

    1998-01-01

    A brief account of activities in international co-operation carried out by the Nuclear power plants Jaslovske Bohunice in 1997 is presented. Professionality of the Bohunice NPPs staff was highly appreciated by inviting them to be the OSART team members

  17. Internal budget control

    Directory of Open Access Journals (Sweden)

    MSc. Mervete Shala

    2011-06-01

    Generally, duties of internal control officers within ministries and institutions must be clearly divided to reduce the risk of inco-rrect behaviour. Operations of an efficient control mechanism influence and ensure conditions for rule of law, good governance, and democracy.

  18. Internalized homophobia in Russia

    Directory of Open Access Journals (Sweden)

    Alexander A. Yanykin

    2017-06-01

    Full Text Available Objective. The goal of this study was to empirically verify that the combination of negative attitudes of LGB people towards homosexuality in general and to their own personal characteristics associated with a gay orientation has a negative impact on their self-esteem. Design. To test this hypothesis we adapted and standardized the Russian version of the personal homonegativity scale (Mayfield, 2001. Using the adapted measure, we studied how personal homonegativity affects the self-esteem of LGB people. We explored the reliability and validity of the adapted measure with 92 gay respondents aged over 21. Confirmatory factor analysis revealed a two-scale structure — the method was proved. The modified measure includes ten statements divided into two scales: Homonegativity (internalized homophobia; Cronbach’s alpha =0.96 and Acceptance of one’s own homosexuality (Cronbach alpha’s = 0.88. The results indicated that the adapted measure was suitable for assessing internalized homonegativity among gay individuals in Russia. Results. More than a half of the respondents (55.4 % had a rather low level of internalized homophobia which was related to fewer neurotic symptoms and emotional discomfort in comparison with other respondents. However, a higher level of internalized homophobia in remaining respondents (44.6 % was related to a more positive emotional acceptance of their own homosexuality and to a higher level of self-esteem. Conclusion. The results of the analyses of the original hypothesis were confirmed only partially. Internalized homophobia of LGB people appeared to adversely affect the severity of neurotic symptoms and subjective well-being.

  19. International space science

    International Nuclear Information System (INIS)

    Mark, H.

    1988-01-01

    The author begins his paper by noting the range of international cooperation which has occured in science since its earliest days. The brightest minds were allowed to cross international frontiers even in the face of major wars, to work on their interests and to interact with like minded scientists in other countries. There has of course been a political side to this movement at times. The author makes the point that doing science on an international basis is extemely important but it is not a way of conducting foreign policy. Even though governments may work together on scientific efforts, it is no glue which will bind them to work together on larger political or economic issues. The reason for doing science on an international basis is that it will lead to better science, not better international relations. There are a limited number of great scientists in the world, and they must be allowed to develop their talents. He then discusses two internationl space programs which have has such collaboration, the Soviet-American Space Biology Program, and the Infrared Astronomical Satellite (IRAS). He then touches on the NASA space exploration program, and the fact that its basic objectives were laid out in the 1940's and l950's. With this laid out he argues in favor of establishment of a lunar base, one of the key elements of NASA's plan, arguing for the value of this step based upon the infrared astronomical work which could be done from a stable lunar site, away from the earth's atmosphere

  20. International fusion research

    International Nuclear Information System (INIS)

    Pease, R.S.

    1983-01-01

    Nuclear energy of the light elements deuterium and lithium can be released if the 100 MK degree temperature required for deuterium-tritium thermonuclear fusion reactions can be achieved together with sufficient thermal insulation for a net energy yield. Progress of world-wide research shows good prospect for these physical conditions being achieved by the use of magnetic field confinement and of rapidly developing heating methods. Tokamak systems, alternative magnetic systems and inertial confinement progress are described. International co-operation features a number of bilateral agreements between countries: the Euratom collaboration which includes the Joint European Torus, a joint undertaking of eleven Western European nations of Euratom, established to build and operate a major confinement experiment; the development of co-operative projects within the OECD/IEA framework; the INTOR workshop, a world-wide study under IAEA auspices of the next major step in fusion research which might be built co-operatively; and assessments of the potential of nuclear fusion by the IAEA and the International Fusion Research Council. The INTOR (International Tokamak Reactor) studies have outlined a major plant of the tokamak type to study the engineering and technology of fusion reactor systems, which might be constructed on a world-wide basis to tackle and share the investment risks of the developments which lie ahead. This paper summarizes the recent progress of research on controlled nuclear fusion, featuring those areas where international co-operation has played an important part, and describes the various arrangements by which this international co-operation is facilitated. (author)

  1. Sensor employing internal reference electrode

    DEFF Research Database (Denmark)

    2013-01-01

    The present invention concerns a novel internal reference electrode as well as a novel sensing electrode for an improved internal reference oxygen sensor and the sensor employing same.......The present invention concerns a novel internal reference electrode as well as a novel sensing electrode for an improved internal reference oxygen sensor and the sensor employing same....

  2. Internal audit consider the implications.

    Science.gov (United States)

    Baumgartner, Grant D; Hamilton, Angela

    2004-06-01

    Internal audit can not only allay external and internal concerns about appropriateness of business operations, but also help improve efficiency and the bottom line. To get an internal audit function under way, healthcare organizations need to obtain board buy-in, form an audit committee of the board, determine resources needed, perform a risk assessment, and develop an internal audit plan.

  3. Bowett's law of international institutions

    CERN Document Server

    Sands, Philippe

    2009-01-01

    Bowett's Law of International Institutions is the leading introduction to this complex, important and growing area of international law, with increasing significance for developments at the national level. Covering all the major global, regional and judicial institutions and all international organisations that regulate aspects of development and providing an introductory overview of the law of international organisations, including international courts and tribunals as a whole. The book offers a basic framework, insights into some of the more essential issues, and indications of where to find more detail. Bowett's is essential reading for students of international law and international relations and will also be of considerable interest to lawyers practising in the area.

  4. International Satellite Law

    Science.gov (United States)

    von der Dunk, Frans

    2017-07-01

    International space law is generally considered to be a branch of public international law. In that sense, it constitutes a "subset of rules, rights and obligations of states within the latter specifically related to outer space and activities in or with respect to that realm." Dealing with an inherently international realm, much of it had been developed in the context of the United Nations, where the key treaties are even adhered to by all major space-faring countries. In addition, other sources—including not only customary international law but also such disputed concepts as "soft law" and political guidelines and recommendations—also contributed to the development of a general framework legal regime for all of mankind's endeavors in or with respect to outer space. Originally, this predominantly included scientific and military/security-related activities, but with the ongoing development of technology and a more practical orientation, it increasingly came to encompass many more civilian and, ultimately, even commercial activities, largely through downstream applications originating from or depending on space technology and space activities. Important here are the overarching, usually more theoretical aspects of international space law, which include how it was developed or continues to be developed, what special roles do "soft law" or the military aspects of space activities play in this regard, and how do national space laws (also) serve as a tool for interpretation of international space law. Also important is the special category of launches and other space operations in the sense of moving space objects safely into, through and—if applicable—back from outer space. Without such operations, space activities would be impossible, yet they bring with them special concerns; for instance, in terms of liability, the creation of space debris and even the legal status and possible commercialization of natural resources produced from celestial bodies. Finally

  5. Factors Affecting the Internal Audit Effectiveness

    OpenAIRE

    Mustika, Adhista Cahya

    2015-01-01

    This study tests the factors that influence the internal audit effectiveness, including internal auditor competencies, internal auditor independence, auditee support to internal audit activity, and the internal and external auditor relationship. Using the internal auditor inspectorate in Java Province, Indonesia, we found that the internal audit effectiveness can be attained through increase internal audit competence, independence and strong relationship between internal and external auditor....

  6. The Development of Customary International Law by International Organizations

    DEFF Research Database (Denmark)

    Odermatt, Jed

    2017-01-01

    In his Fourth Report on the Identification of Customary International Law (2016), Special Rapporteur Michael Wood confirmed that ‘[i]n certain cases, the practice of international organizations also contributes to the expression, or creation, of rules of customary international law.......’ That the practice of international organizations can be relevant when identifying customary international law is relatively uncontroversial. The practice of states within international organizations such as the UN General Assembly, for example, may contribute to the development of custom. Yet, there is little...... discussion about whether and how the practice of international organizations as such may contribute to the development of customary international law. This contribution discusses the organization that is the most capable of contributing to the development of customary international law in its own right...

  7. International Lunar Decade Status

    Science.gov (United States)

    Beldavs, VZ; Crisafulli, J.; Dunlop, D.; Foing, B.

    2017-09-01

    The International Lunar Decade is a global decadal event designed to provide a framework for strategically directed international cooperation for permanent return to the Moon. To be launched July 20, 2019, the 50th anniversary of the giant leap for mankind marked by Neil Armstrong's first step on the Moon, the ILD launch will include events around the world to celebrate space exploration, science, and the expansion of humanity into the Solar System. The ILD framework links lunar exploration and space sciences with the development of enabling technologies, infrastructure, means of financing, laws and policies aimed at lowering the costs and risks of venturing into space. Dramatically reduced costs will broaden the range of opportunities available in space and widen access to space for more states, companies and people worldwide. The ILD is intended to bring about the efflorescence of commercial business based on space resources from the Moon, asteroids, comets and other bodies in the Solar System.

  8. International energy outlook, 1992

    International Nuclear Information System (INIS)

    1992-01-01

    This report presents the current Energy Information Administration (EIA) assessment of the long-term outlook for international energy markets. The historic political and economic changes occurring in Easter Europe and the former Soviet Union will, no doubt, transform regional markets and world trade. This report pays particular attention to energy markets and resources in those countries that were once a part of the Centrally Planned Economies (CPE's) and how prospective changes in these countries might influence the energy outlook for the rest of the world. Several major EIA estimates determine, in large part, the resulting energy projections presented here. These include estimates of the energy intensity of economic activity; oil and natural gas production capacities; nuclear and hydroelectric generation capacities; international coal trade; and the rate of incremental energy requirements met by alternatives to oil

  9. International plutonium policy

    International Nuclear Information System (INIS)

    1978-12-01

    The need to distinguish between diversion by sub-national groups and by governments is clearly stated. The paper identifies the international safeguards measures which already exist for the handling of plutonium. It proposes that the implementation of Article XII A5 of the IAEA statute concerning the international storage of plutonium could be an important additional measure. The paper also mentions the concept of using confinement as a complimentary safeguards measure and identifies the PIPEX concept. In addition, greater use is proposed of containment and surveillance procedures. The multiplication of small reprocessing plants spread over many countries is perceived as a proliferation risk. Other means such as co-location of reprocessing and fuel fabrication facilities are relevant to diversion by sub-national groups

  10. International regulatory activities

    International Nuclear Information System (INIS)

    Anon.

    2010-01-01

    Concerning International regulatory activities, we find for the european atomic energy community an entry into force of the lisbon treaty (2009), it amends the treaty on European union and replaces the treaty establishing the European Community by the new treaty on the functioning of the European Union; more, an amendment to council regulation on the conditions governing imports of agricultural products originating in third countries following the accident at the Chernobyl nuclear power station (2009). About International atomic energy agency is reported an open-ended meeting of technical and legal experts for sharing of information on states implementation of the code of conduct on the safety and security of radioactive sources and its supplementary guidance on the import and export of radioactive sources (2010). (N.C.)

  11. The international petrochemical industry

    International Nuclear Information System (INIS)

    Chapman, K.

    1991-01-01

    The petrochemical industry occupies a crucial place in economic, strategic and political terms in the twentieth century. The author explains its growth and international distribution from the 1920s tot he present, relating the particular experience of petrochemicals to the processes that have shaped the long-term evolution of industry in general. The geographical coverage of this book extends from the regional to international scale, and its historical scope embraces one hundred years from the laboratory origins of polymer science and petrochemistry to the massive operations of modern industry. It represents the result of twenty years of research, and reflects the author's privileged access to company sources in both the U.S. and Europe

  12. Retrievability: An international overview

    International Nuclear Information System (INIS)

    Richardson, P.J.

    2000-01-01

    Using available information from the published literature and material obtained from a network of contacts, a short introductory overview of international developments in the field of retrievability of emplaced nuclear waste was produced for the Swedish National Siting Coordinator for Nuclear Waste Disposal. This examined the issue in terms of a number of basic questions: Definition, Need, Design Implications, Safeguards for Fissile Material, Public Acceptability and Safety Assessment. The report was submitted in February 1999, and acted as a catalyst for the organisation of an international seminar by KASAM, the Swedish National Council for Nuclear Waste (these proceedings). This paper describes the report contents, and points to the invited papers at the seminar which expand on and update the limited descriptions in the original report. (author)

  13. International safeguards 1979

    International Nuclear Information System (INIS)

    Fischer, D.

    1979-01-01

    First, the nature of the nuclear proliferation problem is reviewed. Afterward, the extent to which the risk of further horizontal proliferation of nuclear weapons is being contained by international agreements and by the application of the IAEA's safeguards under these agreements is investigated. The geographical scope of such safeguards, the gaps in safeguards coverage, and the political and technical effectiveness of such safeguards are examined. In conclusion, it is pointed out that IAEA safeguards are the cutting edge of almost every nonproliferation measure that has so far been applied or put forward. Safeguards would also play a part in any international scheme for limiting vertical proliferation. If the cutting edge of safeguards is blunted or if, for one reason or another, safeguards cannot be or are not being applied, the nonproliferation regime will suffer commensurate damage

  14. Analysing international relations

    DEFF Research Database (Denmark)

    Corry, Olaf

    2014-01-01

    matters by depicting reality in new ways. I then show how different theories rely on different ‘pictures’ of what makes up the international system. Section 2 shows how theories differ in terms of their scope, their aims and their purposes. Section 3 explores some of the choices to be made when using...... theories to ‘explain’ international relations and distinguishes between different kinds of explanation. In Section 4 I look at how different theories have been grouped – first according to their underlying views of what is valid knowledge, and second in terms of different accounts of how history works.......Presented with conflicting evidence and interpretations, how do we ever come to valid conclusions about complex questions of continuity and change in global politics? In any analytical task you need to consider a number of things and this final chapter will take you through some of them including...

  15. Genetic discrimination: international perspectives.

    Science.gov (United States)

    Otlowski, M; Taylor, S; Bombard, Y

    2012-01-01

    Genetic discrimination (GD) is a complex, multifaceted ethical, psychosocial, and legal phenomenon. It is defined as the differential treatment of asymptomatic individuals or their relatives on the basis of their real or assumed genetic characteristics. This article presents an overview of GD within the contemporary international context. It describes the concept of GD and its contextual features, reviews research evidence regarding people's experiences of GD and the impact of GD within a range of domains, and provides an overview of legal and policy responses to GD that have emerged globally. We argue that GD is a significant and internationally established phenomenon that requires multilevel responses to ensure social justice and equitable outcomes for all citizens. Future research should monitor GD and its impacts within the community as well as institutions and should evaluate the effectiveness of legislative, policy, community education, and systemic responses.

  16. Financing Canadian international operations

    International Nuclear Information System (INIS)

    Beagle, G.

    1996-01-01

    A primer on financing international operations by Canadian corporations was provided. Factors affecting the availability to project finance (location, political risk), the various forms of financing (debt, equity, and combinations), the main sources of government backed financing to corporations (the International Finance Corporation) (IFC), the European Bank for Reconstruction and Development (EBRD), the Asian Development Bank (ADB), the Overseas Property Insurance Corporation (OPIC), government or agency guarantees, political risk coverage, the use of offshore financial centres, and the where, when and how these various organizations operate, were reviewed. Examples of all of the above, taken from the experiences of Canadian Occidental Petroleum of Calgary in the U.S., in South America, in the Middle and Far East, and in Kazakhstan, were used as illustrations. figs

  17. Internal core tightener

    International Nuclear Information System (INIS)

    Brynsvold, G.V.; Snyder, H.J. Jr.

    1976-01-01

    An internal core tightener is disclosed which is a linear actuated (vertical actuation motion) expanding device utilizing a minimum of moving parts to perform the lateral tightening function. The key features are: (1) large contact areas to transmit loads during reactor operation; (2) actuation cam surfaces loaded only during clamping and unclamping operation; (3) separation of the parts and internal operation involved in the holding function from those involved in the actuation function; and (4) preloaded pads with compliant travel at each face of the hexagonal assembly at the two clamping planes to accommodate thermal expansion and irradiation induced swelling. The latter feature enables use of a ''fixed'' outer core boundary, and thus eliminates the uncertainty in gross core dimensions, and potential for rapid core reactivity changes as a result of core dimensional change. 5 claims, 12 drawing figures

  18. Dynamic international oil markets

    International Nuclear Information System (INIS)

    van der Linde, C.

    1992-01-01

    Dynamic International Oil Market Developments and Structure 1860-1990 discusses the logic of changing market structures of the international oil industry. The market structures have, in the course of time, oscillated between competition and oligopoly, as the oil market expanded, matured, stagnated, and expanded again. This book provides a dynamic interpretation of the intensifying struggle among producer, and consumer governments, and oil companies, over the distribution of economic rents and profits. In particular, it shows the shifting fortunes of the governments and companies as they try to control the recurring capacity constraints between the upstream and downstream sectors, generated by the instability of the oil market. The first part of the book examines market conditions and developments between 1860 and 1990; the second part analyzes market structures after 1945

  19. International nuclear energy guide

    International Nuclear Information System (INIS)

    Anon.

    1983-01-01

    Separate abstracts are included for each of the papers presented concerning current technical and economical events in the nuclear field. Twelve papers have been abstracted and input to the data base. The ''international nuclear energy guide'' gives a general directory of the name, the address and the telephone number of the companies and bodies quoted in this guide; a chronology of the main events 1982. The administrative and professional organization, the nuclear courses and research centers in France are presented, as also the organization of protection and safety, and of nuclear fuel cycle. The firms concerned by the design and the construction of NSSS and the allied nuclear firms are also presented. The last part of this guide deals with the nuclear energy in the world: descriptive list of international organizations, and, the nuclear activities throughout the world (alphabetical order by countries) [fr

  20. Geneva international synergies

    CERN Multimedia

    2010-01-01

    Geneva has a long history of hosting international organizations, which is part of the reason why CERN is here, and it makes the canton an ideal place to forge links between such organizations. Over recent weeks, CERN has signed agreements with the ITU, WIPO and the WMO. At first sight, there may not seem to be much common ground between CERN and, say, the World Meteorological Organization, but scratch the surface, and you’ll soon find a common thread. All of these organizations have a vocation to stimulate technological innovation, and together we’re stronger.   Let’s start with ITU, the International Telecommunications Union. There, the synergies are evident. When ITU organized the World Summit on the Information Society in 2003, CERN provided a significant side event examining the Role of Science in the Information Society. The current agreement builds on that, allowing our two organizations to work together on important societal issues such as the extension of b...

  1. International Water Center

    Science.gov (United States)

    The urban district of Nancy and the Town of Nancy, France, have taken the initiative of creating an International Center of Water (Centre International de l'Eau à Nancy—NAN.C.I.E.) in association with two universities, six engineering colleges, the Research Centers of Nancy, the Rhine-Meuse Basin Agency, and the Chamber of Commerce and Industry. The aim of this center is to promote research and technology transfer in the areas of water and sanitation. In 1985 it will initiate a research program drawing on the experience of 350 researchers and engineers of various disciplines who have already been assigned to research in these fields. The research themes, the majority of which will be multidisciplinary, concern aspects of hygiene and health, the engineering of industrial processes, water resources, and the environment and agriculture. A specialist training program offering five types of training aimed at university graduates, graduates of engineering colleges, or experts, will start in October 1984.

  2. International operations networks

    CERN Document Server

    Farooq, Sami; Cheng, Yang

    2014-01-01

    Although the area of International Manufacturing Network (IMN) and International Operations Network (ION) has received considerable attention in the literature, most of studies appear multifaceted and interdisciplinary, and thereby require thorough investigation from both academic and practical perspectives, in order to deepen our related understanding. The book seeks advanced contributions that will combine theoretical insights and empirical experience by offering a detailed examination of IMN and, further, ION from various perspectives. This book can be used as a reference material for scholarpractitioners, business executives, and university researchers who need to deepen their understanding on the importance and influence of IMN and ION as well as their development. The book is important because there are few reference/resource materials available related to IMN and ION.

  3. International Nuclear Security

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, James E. [Los Alamos National Laboratory

    2012-08-14

    This presentation discusses: (1) Definitions of international nuclear security; (2) What degree of security do we have now; (3) Limitations of a nuclear security strategy focused on national lock-downs of fissile materials and weapons; (4) What do current trends say about the future; and (5) How can nuclear security be strengthened? Nuclear security can be strengthened by: (1) More accurate baseline inventories; (2) Better physical protection, control and accounting; (3) Effective personnel reliability programs; (4) Minimize weapons-usable materials and consolidate to fewer locations; (5) Consider local threat environment when siting facilities; (6) Implement pledges made in the NSS process; and (7) More robust interdiction, emergency response and special operations capabilities. International cooperation is desirable, but not always possible.

  4. Celebrities in International Affairs

    DEFF Research Database (Denmark)

    Richey, Lisa Ann; Budabin, Alexandra Cosima

    2016-01-01

    Celebrity engagement in global “helping” is not a simple matter of highly photogenic caring for needy others across borders; it is a complex relationship of power that often produces contradictory functions in relation to the goals of humanitarianism, development, and advocacy. This article argues...... that celebrities are acting as other elite actors in international affairs: investing considerable capital into processes that are highly political. It traces the emergence and practices of the elite politics of celebrities in North-South relations, an evolution made possible by recent changes in aid practices......, media, and NGOs, then considers exemplary cases of Angelina Jolie in Burma, Ben Affleck in the Democractic Republic of Congo, and Madonna in Malawi. These celebrity practices as diplomats, experts, and humanitarians in international affairs illustrate the diverse and contradictory forms of engagement...

  5. From Public International to International Public Law: Translating World Public Opinion into International Public Authority

    NARCIS (Netherlands)

    von Bogdandy, A.; Goldmann, M.; Venzke, I.

    This article argues that increasing demands in world public opinion for legitimate and effective international institutions require a paradigm shift in public international law. There is a part of public international law that should be better understood as international public law because it

  6. International co-operation

    International Nuclear Information System (INIS)

    1997-01-01

    In 1996, Nuclear Regulatory Authority of the Slovak Republic (NRA SR) ensured the Slovak Republic (SR) obligations with relation to the international agreements and with the SR membership in the IAEA.International co-operation has been ensured on the basis of the bilateral international agreements. With the Ministry of Foreign Affairs co-operation, the SR fulfilled its financial obligations to this organization in due time and in the full scope. Representing Central and Eastern Europe interest in the Board of Governors, the SR participation in the highest executive in the highest executive authority was finished in 1996.The Board of Governors Vice-chairman position was executed by NRA SR Chairman. 5 national and 6 regional technical co-operation and assistance projects were realized in 1996. 12 organizations participated in these projects and accordingly 104 experts took part in training programmes, scientific visits or as the mission members abroad. Besides, Slovak experts participated at work of technical advisory and consultation groups with the significant assistance. In the framework of IAEA co-operation, the SR was visited by 11 expert missions formed by 28 experts from 19 countries including IAEA. Slovak organizations, namely institutes of the Academy of Sciences, Slovak research centres and universities participated in IAEA scientific and research activities through NRA SR. 15 scientific contracts in total were approved and realized and these contracts are utilized as supplementary financing of the own scientific and research projects. Other international co-operation and regional co-operation activities of the NRA SR in 1996 are reviewed

  7. International power plant business

    Energy Technology Data Exchange (ETDEWEB)

    Grohe, R.

    1986-03-03

    At the Brown Boveri press seminar 'Energy' in Baden-Baden Rainer Grohe, member of the Brown Boveri board, Mannheim, gave a survey of the activities on the international power plant market in recent years. He showed the vacuities which must be taken into account in this sector today. The drastic escalation of demands on power plant suppliers has lead not to a reduction of protagonists but to an increase. (orig.).

  8. International Business Cycle

    OpenAIRE

    Marek Lubiński

    2007-01-01

    Prime stylized facts of international business cycle theory refer to positive correlation in the cyclical components of important macroeconomic variables across countries. However a number of indicators of business cycle synchronization do not point to clear trends. It can be ascribed to the fact that different forces influence level of business cycle correlation. When investigating into the forces behind the commonness in aggregate fluctuations economic research seems to have pointed in two ...

  9. International child health

    DEFF Research Database (Denmark)

    Kruse, Alexandra Y; Høgh, Birthe

    2007-01-01

    International child health has improved. Better healthcare strategies, like IMCI, have contributed implementing basic interventions: vaccinations, nutrition supplement, oral rehydration and antibiotics. But 11 million children still die every year before they turn five, most from infectious...... diseases and neonatal complications, over half associated with malnutrition. Conditions we could prevent and treat. One of UN's Millennium Development Goals is to reduce child mortality. However child health is more than mortality and morbidity indicators, it includes growth and development. Udgivelsesdato...

  10. USSR Report, International Affairs

    Science.gov (United States)

    1987-05-27

    284,1 Export Import 190,1 149,1 41,0 109,4 99,9 9,5 Export Import 212,9 0,2 276,4 7,7 Tunisia Turnover 23,0 38,9 Panama Turnover...11-12, 1982, pp 125-126. 2. OFFSHORE. London, No 7, 1983, pp 90-91. 3. PETROLEUM INTERNATIONAL. Tulsa. No 5, 1982, pp 39-40.’ 4. PETROLE ET

  11. Roget's international thesaurus

    CERN Document Server

    Chapman, Robert L

    2001-01-01

    A classic reference book that has been used by millions all over the world, Roget's International Thesaurus is the product of more than a century and a half of continuous expansion, reorganization, and improvement. Today, this book is not only the most time-tested and bestselling thesaurus ever, but, newly revised, it is also the most up-to-date and comprehensive reflection of the English language as it is currently used.

  12. IKEA's International Expansion

    OpenAIRE

    Harapiak, Clayton

    2013-01-01

    This case concerns a global retailing firm that is dealing with strategic management and marketing issues. Applying a scenario of international expansion, this case provides a thorough analysis of the current business environment for IKEA. Utilizing a variety of methods (e.g. SWOT, PESTLE, McKinsey Matrix) the overall objective is to provide students with the opportunity to apply their research skills and knowledge regarding a highly competitive industry to develop strategic marketing strateg...

  13. International Masterclass at CMS

    CERN Multimedia

    Lapka, M

    2012-01-01

    The CMS collaboration welcomed a class of French high school students to the CERN facility in Meyrin, Switzerland on the 12 of March, 2012. Students spent the day meeting with physicists, hearing talks, asking questions, and participating in a hands-on exercise using real data collected by the CMS experiment on the Large Hadron Colider. Talks and other resources are available here: http://ippog-dev.web.cern.ch/resources/2012/ippog-international-masterclass-2012-cms

  14. International Cryocooler Conference

    CERN Document Server

    Cryocoolers 13

    2005-01-01

    This is the 13th volume in the conference series. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature super-capacitor applications.

  15. INTERNATIONAL ENGLISH MANUAL

    Energy Technology Data Exchange (ETDEWEB)

    AMADOR, MABLE; KELLER, YVONNE KELLER

    2002-02-22

    This document presents a set of guidelines for authors who wish to express themselves more clearly to foreign readers, or readers whose first language is not American English. Topics include idioms, technical terms, jargon, word meaning, acronyms, and international conventions of measurement. The guidelines will help writers of technical documents present their ideas more effectively to audiences that may include individuals whose first language is not American English, including audiences with individuals from other English-speaking countries.

  16. International petroleum statistics report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This document is a monthly publication which provides current data on international oil production,demand,imports and stocks. This report has four sections which contain time series data on world oil production and oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). Also included is oil supply/demand balance information for the world, and data on oil imports and trade by OECD countries.

  17. The uranium International trade

    International Nuclear Information System (INIS)

    Gonzalez U, L.A.

    1993-01-01

    The aim of this thesis is the understanding of how the present dynamic of uranium International trade is developed, the variables which fall into, the factors that are affecting and conditioning it, in order to clarify which are going to be the outlook in the future of this important resource in front of the present ecological situation and the energetic panorama of XXI Century. For this purpose, as starting point, the uranium is considered as a strategic material which importance take root in its energetic potential as alternate energy source, and for this reason in Chapter I, the general problem of raw materials, its classification and present situation in the global market is presented. In Chapter II, by means of a historical review, is explain what uranium is, how it was discovered, and how since the end of the past Century and during the last three decades of present, uranium pass of practically unknown element, to the position of a strategic raw material, which by degrees, generate an International market, owing to its utilization as a basic resource in the generation of energy. Chapter III, introduce us in the roll played by uranium, since its warlike applications until its utilization in nuclear reactors for the generation of electricity. Also is explain the reason for this change in the perception at global level. Finally, in Chapter IV we enter upon specifically in the present conditions of the International market of this mineral throughout the trends of supply and demand, the main producers, users, price dynamics, and the correlation among these economical variables and other factors of political, social and ecological nature. All of these with the purpose to found out, if there exist, a meaning of the puzzle that seems to be the uranium International trade

  18. Enresa International Cooperation

    International Nuclear Information System (INIS)

    Rodriguez Beceiro, A.

    1998-01-01

    The Empresa Nacional de Residuos Radiactivos, S.A. (ENRESA) was set up in 1984 with the mandate to undertake responsibility for radioactive waste management in Spain. From the very beginning, ENRESA was fully aware of the fact that international cooperation plays a very important role in the development of national programmes. Aspects such as the setting up of international databases, the development and validation of models or site characterization technique such enormous efforts and amounts of resources that they could hardly be undertaken individually. Furthermore, joint participation in research, development and demonstration projects reinforces the level of confidence, not only in the decision-making process but also in the technologies, techniques and practices used. ENRESA's participation in the international contexts is largely defined, on the one hand, by the needs arising from its technical programme, as reflected in the General Radioactive Waste Plan and in the Research and Development Plan, and on the other by the need to support spanish governmental institutions in their participation in inter-governmental institutions in their participation in inter-governmental forums. The formula for cooperation varies according to needs, this cooperation generally being accomplished by means of bilateral agreements with other institutions having similar competence or by participating in the programmes of inter-governmental organizations. In particular, ENRESA has reached cooperation agreements with most of the agencies with similar responsibilities in other countries and participates very actively in the programmes of the European Union, the Nuclear energy Agency (NEA/OECD) and the International Atomic Energy Agency (IAEA). (Author)

  19. International SSAC training courses

    Energy Technology Data Exchange (ETDEWEB)

    Bates, O G

    1988-01-01

    State Systems of Accounting for and Control of Nuclear Material (SSACs) are a vital element in achieving effectiveness and creativity for international safeguards. A nation's SSAC must also satisfy national objectives, such as accounting for all safeguarded material and detecting losses or unauthorized removal of material. In recent years the Agency has placed an increasing emphasis on assisting Member States in developing their state system of accountancy and control of nuclear material.

  20. USSR Report, International Affairs

    Science.gov (United States)

    1987-04-08

    extensive business with the Swedish firm IKEA which coop- erated in the reconstruction of furniture-making facilities in the Republic in exchange for...Struggle"] [Excerpts] Twenty years ago, on 12 February 1967, Turkey’s new trade union center, which has made a vivid contribution to the history of the...The international trade union movement’s history convincingly shows that repression against progressive trade unions cannot halt the development

  1. International markets for CCTs

    Energy Technology Data Exchange (ETDEWEB)

    Ferriter, J.P. [International Energy Agency, Paris (France)

    1997-12-31

    The paper begins by describing the role of the International Energy Agency, the importance of coal, what the IEA is doing in the area of clean coal technology, and the role of the IEA Coal Industry Advisory Board. The paper then discusses which coal technologies will be chosen, what the problem areas are, and what can be done to accelerate the take-up of clean coal technologies.

  2. International SSAC training courses

    International Nuclear Information System (INIS)

    Bates, O.G.

    1988-01-01

    State Systems of Accounting for and Control of Nuclear Material (SSACs) are a vital element in achieving effectiveness and creativity for international safeguards. A nation's SSAC must also satisfy national objectives, such as accounting for all safeguarded material and detecting losses or unauthorized removal of material. In recent years the Agency has placed an increasing emphasis on assisting Member States in developing their state system of accountancy and control of nuclear material

  3. International Buyers' guide 1978

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    A guide is presented of manufactures, consultants, architect engineers and specialist service companies in the nuclear industry. The guide which is in three sections, supplies the following information: addresses of principal national and international agencies and nuclear organisations; addresses etc of companies in all major countries serving the nuclear industry; a list classified in terms of products and services and grouped according to country showing in which fields the companies operate. (author)

  4. Liquidity and International Trade

    OpenAIRE

    Rodriguez-Lopez, Antonio

    2016-01-01

    This paper introduces a framework to study the links between the supply of liquid assets for the financial market and the international allocation of economic activity. Private assets’ liquidity properties - their usefulness as collateral or media of exchange in financial transactions - affect assets’ values and interest rates, with consequences on firm entry, production, aggregate productivity, and total market capitalization. In a closed economy, the liquidity market increases the size and ...

  5. International Social Pharmacy Workshop

    OpenAIRE

    Cordina, Maria; Journal of the Malta College of Pharmacy Practice Editorial Board

    2003-01-01

    The Malta College of Pharmacy Practice, will be hosting the 13th International Social Pharmacy Workshop next summer. The concept of social pharmacy is very clearly explained in the article by Professor Ellen West Sørensen and colleagues, who are considered to be pioneers in this field. Malta has successfully hosted a number of pharmacy conferences, however this one is somewhat different and rather special.

  6. Internal control system

    OpenAIRE

    Pavésková, Ivana

    2014-01-01

    Dissertation focuse on the internal control system in the enterprises, aims to map the control system by focusing on the purchasing department. I focused on the purchasing process, because with an increasing trends of outsourcing services and the increasing interconnectedness of enterprises increases the risk of fraud currently in the purchasing process. To the research was selected the sample of companies from the banking and non-banking environment, to which were sent a questionnaire focusi...

  7. International technology transfer

    International Nuclear Information System (INIS)

    Kwon, Won Gi

    1991-11-01

    This book introduces technology progress and economic growth, theoretical consideration of technology transfer, policy and mechanism on technology transfer of a developed country and a developing country, reality of international technology transfer technology transfer and industrial structure in Asia and the pacific region, technology transfer in Russia, China and Eastern Europe, cooperation of science and technology for development of Northeast Asia and strategy of technology transfer of Korea.

  8. International mathematical olympiad

    OpenAIRE

    Hanjš, Ž.

    1999-01-01

    Today mathematical competitions are very popular with primary and secondary school students and there are many countries all around the world where they are regularly organised. There are several rounds and a lot of students are included, especially at the beginning rounds. The best students from the previous round have the right to continue on the higher level of competition. The final level for the secondary school student competitors is the International Mathematical Olympiad (IMO). The te...

  9. International Data Centre (IDC)

    International Nuclear Information System (INIS)

    Johansson, P.

    2002-01-01

    The presentation outlines the International Data Centre (Indc) mission, objective and historical background. The Indc progressive commissioning and organizational plans are presented on charts. The IMS stations providing data to Indc operations and the global communication infrastructure are plotted on world maps. The various types of IMS data are thus listed as seismic, hydroacoustic, infrasound and radionuclide. Finally Indc products and services together with its main achievements are listed

  10. File: International bilateral relations

    International Nuclear Information System (INIS)

    Feltin, Ch.; Rabouhams, J.; Bravo, X.; Rousseau, M.; Le Breton, S.; Saint Raymond, Ph.; Brigaud, O.; Pertuis, V.; McNair, J.; Sayers, M.R.; Bye, R.; Scherrer, J.

    1998-01-01

    Since its creation in 1973, the Authority of Safety was assigned missions in the international field with following objectives: to develop information exchanges with its foreign counterpart, to make know and to explain the French approach and practice; to give to concerned countries the useful information on french nuclear facilities situated near the border; This file shows with some examples, how bilateral relations allow to fill up these objectives and how the French Authority got the foreign experience. (N.C.)

  11. Internally plasticised cellulose polymers

    International Nuclear Information System (INIS)

    Burnup, M.; Hayes, G.F.; Fydelor, P.J.

    1981-01-01

    Plasticised cellulose polymers comprise base polymer having a chain of β-anhydroglucose units joined by ether linkages, with at least one of said units carrying at least one chemically unreactive side chain derived from an allylic monomer or a vinyl substituted derivative of ferrocene. The side chains are normally formed by radiation grafting. These internally plasticised celluloses are useful in particular as inhibitor coatings for rocket motor propellants and in general wherever cellulose polymers are employed. (author)

  12. IMPLEMENTATION THROUGH INTERNAL MARKETING

    OpenAIRE

    Luigi Dumitrescu

    2009-01-01

    The paper takes into consideration the role of internal marketing in enhancing and sustaining a company’s ability to compete: · much new thinking and practice in strategic marketing is concerned with managing relationships: with the customer, and with partners in strategic alliances. However, a further aspect of relationship management and relationship marketing is the relationship with the employees and managers, upon whose skills, commitment and performance the success of a marketing strate...

  13. The international law commission and international environmental law

    International Nuclear Information System (INIS)

    Ramcharan, B.G.

    1975-01-01

    If the oceans are destroyed through pollution there will be nothing left to manage. Protection against pollution is thus a fundamental aspect of ocean management. What legal principles are available for the protection of the oceans. This paper brings together the relevant practice of the foremost international body responsible for the codification and development of international law: the International Law Commission. It describes the work of the Commission concerning: 1) pollution of the high seas; 2) pollution of international watercourses; and 3) international responsibility for environmental hazards. It concludes by expressing the hope that the Commission will further study, codify and develop international environmental law

  14. International petroleum statistics report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    The International Petroleum Statistics Report is a monthly publication that provides current international data. The report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent 12 months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1996; OECD stocks from 1973 through 1996; and OECD trade from 1986 through 1996.

  15. Editorial: International Entrepreneurial Orientation

    Directory of Open Access Journals (Sweden)

    Krzysztof Wach

    2015-06-01

    Full Text Available In recent decades, both the theory of internationalisation of the firm and/or the theory of international business have developed. Recent developments in international business studies prove that entrepreneurial orientation (EO emerges as one of the important potential factors contributing to the intensification of the processes of internationalisation of the firm (Etemad, 2015; Gupta & Gupta, 2015. It seems that international entrepreneurship (IE has been flourishing. The general theory of entrepreneurship indicates that market opportunities are a common and dominant link for all entrepreneurial activities. The entrepreneurship theory refers to the identification or creation opportunities, their evaluation and exploitation. The expansion into new geographic markets is undoubtedly an important market opportunity for growth and development. The internationalisation as a response to the market opportunity takes diverse paths. Based on the in-depth literature search, this issue of our journal aims to determine whether, why and how, in the context of diverse environmental conditions, the pursuit of market opportunities contributes to the increase of internationalisation of the firm (Dimitratos & Plakoyiannaki, 2003; Dimitratos, Voudouris, Plakoyiannaki & Nakos,. 2012; Wach. 2015.

  16. International energy financing

    International Nuclear Information System (INIS)

    Vedavalli, Rangaswamy

    1994-01-01

    Some of the innovative financing options being considered by developing countries and economies in transition as ways of mobilizing international energy financing are discussed. Build-Own-Operate (BOO) and Transfer (BOOT) is the most commonly adopted approach. This involves limited resource financing of a project on the basis of the associated cash flow and risks and not on the credit of the project owners. The World Bank has set up the Multilateral Investment Guarantee Agency to provide, on a fee basis, guarantees against certain non-commercial forms of risk in order to promote international capital flow to developing countries. In 1989, the World Bank introduced the Expanded Co-financing Operations (ECO) programme as an instrument to catalyze the flow of private finance into developing countries and to improve their access to international financial markets. Other financial instruments currently being established include: leasing of equipment or whole plants by foreign investors; private ownership or operation of generation and distribution facilities; exchange of specific export goods for energy imports; developing instruments to finance local costs; revenue bonds; tax-exempt bonds; sale of electricity futures to those seeking more stable, longer term electricity price contracts. (UK)

  17. The international Chernobyl project

    International Nuclear Information System (INIS)

    1991-01-01

    This article summarizes the official report of the International Advisory Committee at the conference of the International Chernobyl Project held in Vienna, May 1991. More details will be found in the actual report, ''The International Chernobyl Project: An Overview'' (INI22:066284/5). Measurements and assessments carried out under the project provided general corroboration of the levels of surface cesium-137 contamination reported in the official maps. The project also concluded that the official procedures for estimating radiation doses to the population were scientifically sound, although they generally resulted in overestimates of two- to threefold. The project could find no marked increase in the incidence of leukemia or cancer, but reported absorbed thyroid doses in children might lead to a statistically detectable rise in the incidence of thyroid tumors. Significant non-radiation-related health disorders were found, and the accident had substantial psychological consequences in terms of anxiety and stress. The project concluded that the protective measures taken were too extreme, and that population relocation and foodstuff restrictions should have been less extensive

  18. International nuclear material safeguards

    International Nuclear Information System (INIS)

    Syed Azmi Syed Ali

    1985-01-01

    History can be a very dull subject if it relates to events which have long since lost their relevance. The factors which led to the creation of the International Atomic Energy Agency (IAEA), however, are as important and relevant today as they were when the Agency was first created. Without understanding these factors it is impossible to realise how important the Agency is in the present world or to understand some of the controversies surrounding its future. Central to these controversies is the question of how best to promote the international transfer of nuclear technology without contributing further to the problem of proliferating nuclear explosives or explosive capabilities. One effective means is to subject nuclear materials (see accompanying article in box), which forms the basic link between the manufacture of nuclear explosives and nuclear power generation, to international safeguards. This was realized very early in the development of nuclear power and was given greater emphasis following the deployment of the first two atomic bombs towards the end of World War II. (author)

  19. Fair trade international surrogacy.

    Science.gov (United States)

    Humbyrd, Casey

    2009-12-01

    Since the development of assisted reproductive technologies, infertile individuals have crossed borders to obtain treatments unavailable or unaffordable in their own country. Recent media coverage has focused on the outsourcing of surrogacy to developing countries, where the cost for surrogacy is significantly less than the equivalent cost in a more developed country. This paper discusses the ethical arguments against international surrogacy. The major opposition viewpoints can be broadly divided into arguments about welfare, commodification and exploitation. It is argued that the only valid objection to international surrogacy is that surrogate mothers may be exploited by being given too little compensation. However, the possibility of exploitation is a weak argument for prohibition, as employment alternatives for potential surrogate mothers may be more exploitative or more harmful than surrogacy. It is concluded that international surrogacy must be regulated, and the proposed regulatory mechanism is termed Fair Trade Surrogacy. The guidelines of Fair Trade Surrogacy focus on minimizing potential harms to all parties and ensuring fair compensation for surrogate mothers.

  20. Dictionary of international commerce

    CERN Document Server

    Miller, William J

    1985-01-01

    International trade is vital to the well-being of the international market. No textbook suited virtually every nation, because no nation is my purpose, so I set about to write one. capable of satisfying its material needs beyond the subsistence level entirely from domestic My first task was to define my terms-tar­ iffs, non-tariff barriers, shipping terminology, resources. As a nation's technology advances and edu­ etc. As this labor progressed over many cational levels improve, heavy industry and months, it became evident there was need for manufacturing are often supplanted by serv­ an encyclopedic reference work which fo­ ice industries, as evidenced by the economies cused upon international trade. My enquiries of Europe, North America, and Japan. The having divulged no similar work in English, I shift to a service economy increases import decided to concentrate efforts upon an reliance, especially in the areas of consumer encyclopedia. products and basic industrial commodities, In selecting entries, i...

  1. International Humanitarian Award.

    Science.gov (United States)

    2017-12-01

    The International Humanitarian Award recognizes extraordinary humanitarian services and activism by psychologists, including professional and volunteer work conducted primarily in the field with underserved populations. Award recipients are psychologists who, by their extraordinary service at a difficult time, improve the lives and contribute to the well-being of people in a large or small geographic area anywhere in the world. The 2017 recipient of the APA International Humanitarian Award was selected by the 2016 Committee on International Relations in Psychology (CIRP). The members of the 2016 CIRP were Melissa Morgan Consoli, PhD, and Arpana G. Inman, PhD (Co-chairs); Rehman Abdulrehman, PhD; Gonzalo Bacigalupe, EdD; Frederic Bemak, EdD; Brigitte Khoury, PhD; Susan Nolan, PhD; Nancy Sidun, PsyD; and Danny Wedding, PhD. Dr. Morgan Consoli, Dr. Inman, Dr. Nolan, and Doctor Sidun were members of the subcommittee for the 2017 award. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  2. Challenges imposed by International Environmental Law to Classical International Law

    Directory of Open Access Journals (Sweden)

    Fabian Augusto Cárdenas Castañeda

    2010-05-01

    Full Text Available The emergence of international environmental law has produced important challenges to the very foundations of public international law. Traditional concepts such as state sovereignty, subjects of international law, and the early perspectives of national security are being transformed. The needs of the contemporary international society differ from the ones of the Wesphalian conception, situations which clearly explains the raise of alternative views for the understanding of the current dynamics of international law, where concepts like res communis, common concerns and simply “commons” take a privileged place in the study of international law. The foregoing has been strengthened by the international development of the so called erga ommnes obligations, label which is being used by international environmental law as the perfect explanation of its own existence. This academic article presents and studies the abovementioned concepts trying to compare what international law used to be before the emergence of international environmental law and what it is and what it should be in order to attend the developments and challenges imposed by the contemporary international society, particularly by international environmental law, a new fi eld of the corpus juris of public international law.

  3. Director, Risk Management and Internal Audit | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Directs the establishment of an IDRC strategy for Internal Audit that outlines the ... process and are developed with an understanding of IDRC context and business model; ... Planning, Conduct and Reporting of Internal Audit Engagements:.

  4. International health law : an emerging field of public international law

    NARCIS (Netherlands)

    Toebes, Brigit

    This article discusses the nature and scope of international health law as an emerging field of public international law. It is argued that the protection of health reflects a pressing social need that should now be spoken of in the vocabulary of international law. Furthermore, there is an urgent

  5. International safeguards problem

    International Nuclear Information System (INIS)

    Scheinman, L.; Curtis, H.B.

    1977-01-01

    To recognize the limitations of safeguards as a barrier to nuclear proliferation is not to deny their essential role in the effort to contain that problem. Without a safeguards system, international nuclear commerce and development would not, indeed could not, be what they are today. The problems evoked in the discussion of the spread of sensitive nuclear technology underscore the importance of ensuring that activities do not outpace our ability to control them. To sustain a global nuclear economy requires a readiness to live within the constraints that such an economy requires. Enhanced safeguards and strengthened national commitments to facilitate their application are key elements of those constraints. So also may be a prepardness by many nations to forego explicitly national control over all facets of the nuclear fuel cycle while still sharing fully and equally in the benefits of the peaceful atom. The challenge of the coming years will be to craft mechanisms and institutions enabling the continued growth of peaceful nuclear activity without further impairing international security. The constraints that such an outcome entails are not limited to nations lacking sophisticated nuclear technology; they apply to the most advanced nuclear nations as well--partly through adherence to the safeguards system that these countries call upon others to adopt, and partly through greater willingness to entertain solutions that may involve greater international involvement in, and control over, their own peaceful nuclear productive activities. With time, the relative incompatibility of nuclear energy with full national sovereignty, and the far-sighted wisdom of the Baruch Plan, are becoming increasingly clear. 1 table, 10 references

  6. ICFA on international collaboration

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    International collaboration in high energy physics is what ICFA - the International Committee for Future Accelerators - is all about. Progress is highlighted every three years when ICFA convenes its 'Future Perspectives in High Energy Physics' seminar to focus attention on major issues and to identify evolving trends. The latest such seminar, held at the DESY Laboratory in Hamburg from 3-7 May, looked at international cooperation in the construction of major facilities. Status reports across the whole range of existing experimental programmes and ongoing plans gave valuable pointers to future needs. For electron-positron linear colliders (EPLC), research and development work towards the next generation of machines is underway in Laboratories throughout the world. At previous such seminars, at Tsukuba, Japan (1984), Brookhaven, USA (1987) and Protvino (1990), ICFA, which has no direct power, could sometimes only stand on the sidelines and comment on the emergence of major new national plans. The lessons learnt, ICFA is keen to make sure that the EPLC debut on the world stage will be better choreographed. In addition to plans for new major experimental facilities, the Hamburg seminar also provided a valuable snapshot of the current scene and the directions in which ongoing research is poised to take. This covered existing facilities and projects, 'factories' to mass-produce specific particles, fixed target studies and non-accelerator experiments as well as the key EPLC development theme. B-physics, the study of particles containing the fifth, or 'beauty' (b) quark, emerged as an important thread running across several machine scenarios

  7. International regulatory activities

    International Nuclear Information System (INIS)

    Anon.

    2004-01-01

    The 48. session of the IAEA general conference was held in Vienna from 20 to 24 september 2004 with the participation of delegates from 125 members states and representatives of various international organisations. A number of resolutions were adopted by the conference in the following fields: nuclear safety, radiation, transport and waste safety. The general conference also adopted a resolution on measures to protect against nuclear terrorism. The Director General decided in 2003 to appoint a group of experts to explore and advise on issues related to nuclear liability. This group called the International Expert Group on Nuclear Liability (I.N.L.E.X.) consists of 20 experts members from nuclear power and non nuclear power countries and from shipping and non shipping states. It serves three major functions: to create a forum of expertise to explore and advise on issues related to nuclear liability; to enhance global adherence by nuclear and non nuclear states to an effective nuclear liability regime, inter alia, on the basis of the convention on supplementary compensation for nuclear damage and the annex thereto, the Vienna convention on civil liability for nuclear damage, the Paris convention on third party liability in the field of nuclear energy, the joint protocol relating to the application of the vienna convention and the paris convention and the amendments thereto; and to assist in the development and strengthening of the national nuclear liability legal frameworks in IAEA members states to protect the public and the environment and to enhance nuclear safety. The second part of international regulatory concerns a directive on public access to environmental information made by the European Parliament. (N.C.)

  8. Internalized Meaning Factualism

    DEFF Research Database (Denmark)

    Hohwy, Jakob

    2006-01-01

    The normative character of meaning creates deep problems for the attempt to give a reductive explanation of the constitution of meaning. I identify and critically examine an increasingly popular Carnap-style position, which I call Internalized Meaning Factualism (versions of which I argue...... are defended by, e.g., Robert Brandom, Paul Horwich and Huw Price), that promises to solve the problems. According to this position, the problem of meaning can be solved by prohibiting an external perspective on meaning constituting properties. The idea is that if we stick to a perspective on meaning...

  9. International kernekraftstatus 1997

    DEFF Research Database (Denmark)

    Højerup, C.F.; Majborn, Benny; Ølgaard, Povl Lebeck

    1998-01-01

    This report is the fourth in a series of annual reports on the international development of nuclear power with special emphasis on reactor safety. For 1997, the report contains: -General trends in the development of nuclear power -A review of what can bedone with the plutonium stocks of the world...... -Statistical information on nuclear power production -An overview of safety-relevant incidents in 1997 -The development in Sweden -The development in Eastern Europe -The development in the rest of the world -Thetrends in the development of reactor types -The trends in the development of the nuclear fuel cycle...

  10. Internal dosimetry and control

    International Nuclear Information System (INIS)

    Rich, B.L.

    1990-05-01

    This internal dosimetry and control report provides guidance for EG ampersand G Idaho, Inc., field programs in detecting, evaluating, and controlling personnel exposure resulting from uptake of radionuclides by the body. Procedures specific to each program or facility are required to define the details of guidance from this report. Fundamental principles related to philosophy, policies, monitoring guidelines, and dose evaluation are discussed. Specific numerical guides and action levels are developed to guide the programs in evaluating the significance of specific analytical results. The requirement to thoroughly document the results and provide a formal technical base for each policy and/or practice is outlined and explained. 8 refs., 3 figs., 7 tabs

  11. Linearly Adjustable International Portfolios

    Science.gov (United States)

    Fonseca, R. J.; Kuhn, D.; Rustem, B.

    2010-09-01

    We present an approach to multi-stage international portfolio optimization based on the imposition of a linear structure on the recourse decisions. Multiperiod decision problems are traditionally formulated as stochastic programs. Scenario tree based solutions however can become intractable as the number of stages increases. By restricting the space of decision policies to linear rules, we obtain a conservative tractable approximation to the original problem. Local asset prices and foreign exchange rates are modelled separately, which allows for a direct measure of their impact on the final portfolio value.

  12. The internal energy market

    International Nuclear Information System (INIS)

    1988-01-01

    The briefs compile the results of the studies the Commission worked out on the subject on the basis of experiences gained on its own part, on the part of the government and on the part of the market. The briefs are based on the schematic inventory annexed which for each energy sector points out the different existing or potential obstacles to a common energy market the most comprehensive and transparent way possible. Step by step part one and part two discuss the general problems connected with the integration of energy into the internal market, priorities which according to the Commission should be investigated into, and guidelines for such investigations. (orig./UA) [de

  13. Linearly Adjustable International Portfolios

    International Nuclear Information System (INIS)

    Fonseca, R. J.; Kuhn, D.; Rustem, B.

    2010-01-01

    We present an approach to multi-stage international portfolio optimization based on the imposition of a linear structure on the recourse decisions. Multiperiod decision problems are traditionally formulated as stochastic programs. Scenario tree based solutions however can become intractable as the number of stages increases. By restricting the space of decision policies to linear rules, we obtain a conservative tractable approximation to the original problem. Local asset prices and foreign exchange rates are modelled separately, which allows for a direct measure of their impact on the final portfolio value.

  14. STANFORD: Internal targets

    Energy Technology Data Exchange (ETDEWEB)

    Riordan, Michael

    1989-05-15

    Of burgeoning interest to many nuclear and particle physicists is a storage ring technique for fixed target experiments. It hinges on the use of gas-jet targets, shooting a narrow stream of atoms through a circulating beam of electrons or protons. Pioneered at CERN and the Soviet Novosibirsk Laboratory, more such 'internal targets' are being built or contemplated for storage rings in Europe, the Soviet Union, and the United States. From 9-12 January, physicists from around the world met at the Stanford Linear Accelerator Center (SLAC) to discuss prospects and problems in this expanding field.

  15. International energy annual 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    The International Energy Annual presents information and trends on world energy production and consumption for petroleum, natural gas, coal, and electricity. Production and consumption data are reported in standard units as well as British thermal units (Btu). Trade and reserves are shown for petroleum, natural gas, and coal. Data are provided on crude oil refining capacity and electricity installed capacity by type. Prices are included for selected crude oils and for refined petroleum products in selected countries. Population and Gross Domestic Product data are also provided.

  16. International energy annual, 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-08

    This document presents an overview of key international energy trends for production, consumption, imports, and exports of primary energy commodities in over 200 countries, dependencies, and areas of special sovereignty. Also included are population and gross domestic product data, as well as prices for crude oil and petroleum products in selected countries. Renewable energy includes hydroelectric, geothermal, solar and wind electric power and alcohol for fuel. The data were largely derived from published sources and reports from US Embassy personnel in foreign posts. EIA also used data from reputable secondary sources, industry reports, etc.

  17. International energy annual 1995

    International Nuclear Information System (INIS)

    1996-12-01

    The International Energy Annual presents information and trends on world energy production and consumption for petroleum, natural gas, coal, and electricity. Production and consumption data are reported in standard units as well as British thermal units (Btu). Trade and reserves are shown for petroleum, natural gas, and coal. Data are provided on crude oil refining capacity and electricity installed capacity by type. Prices are included for selected crude oils and for refined petroleum products in selected countries. Population and Gross Domestic Product data are also provided

  18. Threats to international science

    Science.gov (United States)

    Kisslinger, Carl

    The role of nongovernmental organizations (NGOs) as effective agents for promoting world science is seriously threatened. It is ironic that the threat comes from Norway and Denmark, two countries that have demonstrated a deep commitment to individual freedom and human rights. Motivated by a sincere desire to express their strongest disapproval of the “apartheid” policies of the government of the Republic of South Africa, these countries have passed laws that have the effect of rejecting the International Council of Scientific Unions (ICSU) principles of nondiscrimination and free circulation of scientists.

  19. International trade in uranium

    International Nuclear Information System (INIS)

    Two reports are presented; one has been prepared by the Uranium Institute and is submitted by the United Kingdom delegation, the other by the United States delegation. The report of the Uranium Institute deals with the influence of the government on international trade in uranium. This influence becomes apparent predominantly by export and import restrictions, as well as by price controls. The contribution submitted by the United States is a uranium market trend analysis, with pricing methods and contracting modes as well as the effect of government policies being investigated in the light of recent developments

  20. Nuclear reactor internals arrangement

    International Nuclear Information System (INIS)

    Frisch, E.; Andrews, H.N.

    1976-01-01

    A nuclear reactor internals arrangement is disclosed which facilitates reactor refueling. A reactor vessel and a nuclear core is utilized in conjunction with an upper core support arrangement having means for storing withdrawn control rods therein. The upper core support is mounted to the underside of the reactor vessel closure head so that upon withdrawal of the control rods into the upper core support, the closure head, the upper core support and the control rods are removed as a single unit thereby directly exposing the core for purposes of refueling

  1. International petroleum statistics report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    This monthly publication provides international oil data for January 1998. The report presents data on oil production, demand, imports, and stocks in four sections. Section 1 containes time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. section 3 presents data on oil imports by OECD countries. Section 4 containes annual time series data on world oil production and oil stocks, demand, and trade in OECD countries.

  2. International energy annual, 1986

    International Nuclear Information System (INIS)

    1987-01-01

    The International Energy Annual presents current data and trends for production, consumption, stocks, imports, and exports for primary energy commodities in more than 190 countries, dependencies, and areas of special sovereignty. Also included are prices on crude petroleum and petroleum products in selected countries. This report is published to keep the public and other interested parties fully informed with respect to primary energy supplies on a global basis. The data presented have been largely derived from published sources and from United States Embassy personnel in foreign posts. The data have been converted to units of measurement and thermal values familiar to the American public

  3. International nuclear trade

    International Nuclear Information System (INIS)

    Biad, A.; Cormis, F. de; Kerever, A.

    1998-01-01

    This third part is relative to the international nuclear trade it includes: the 1996 EURATOM/Usa Agreement on the peaceful Uses of nuclear energy: EURATOM Strengthened, a case study on IVO Power engineering Oy as a supplier to Russia, lessons learned from the Us/EURATOM Agreement for Cooperation, negotiating the parameters of nuclear regulation: lessons from South Africa, Good and new business in Brazil's nuclear energy field, cooperation between Russia and european union in the nuclear field: the legal basis, present status and future prospects, the industrial implications of the non proliferation policy. (N.C.)

  4. Internal examination of CAGR's

    International Nuclear Information System (INIS)

    Walton, P.J.; Langley, J.P.; Simons, C.R.; Hart, J.D.

    1975-01-01

    During selected reactor maintenance periods it will be necessary to conduct examinations of reactor internal components to gain assurance of their continuing integrity throughout the design life. Equipment for remote examination is being developed that will measure the distortions of the graphite moderator bricks and extract samples from them for analysis. Other remotely operated equipment will allow closed circuit TV viewing inside the reactors: the equipment provides both wide field and detailed inspection facilities within a single compact unit. Manipulators are being developed to ring the viewing units to the best vantage points. Reeling and handling gear will be operated from outside the vessels and these provide full containment at all times. (author)

  5. SUPERCOLLIDER: Going international

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    In the wake of the Superconducting Supercollider (SSC) debacle in the US, US particle physicists are regrouping. 'It is clear that physics interest cannot be changed by an act of Congress,' says Ed Berger of Argonne. As part of the SSC winding up, US Secretary of Energy has been requested to produce a plan to 'maximize the value of the investment in the project and minimizing the loss to the US, including recommendations as to the feasibility of utilizing SSC assets in whole or in part in pursuit of an international high energy physics endeavour.'

  6. International conference, ICPRAM 2012

    CERN Document Server

    Sánchez, J; Fred, Ana; Pattern recognition : applications and methods : revised selected papers

    2013-01-01

    This edited book includes extended and revised versions of a set of selected papers from the First International Conference on Pattern Recognition (ICPRAM 2012), held in Vilamoura, Algarve, Portugal, from 6 to 8 February, 2012, sponsored by the Institute for Systems and Technologies of Information Control and Communication (INSTICC) and held in cooperation with the Association for the Advancement of Artificial Intelligence (AAAI) and Pattern Analysis, Statistical Modelling and Computational Learning (PASCAL2). The conference brought together researchers, engineers and practitioners interested on the areas of Pattern Recognition, both from theoretical and application perspectives.

  7. Internal evaluation report

    DEFF Research Database (Denmark)

    Sørensen, Birgitte Holm; Meyer, Bente Tobiesen; Levinsen, Karin

    2006-01-01

    It is the aim of this report to assess and evaluate the internal communication and management of the Lancelot project during the first year of the project's life (October 2005- October 2006). The report focuses on these issues through the perspective of a SWOT analysis carried out by the project...... members at the interim meeting in Manchester October 6-8. The SWOT analysis was chosen for its ability to identify problem areas within an organisation or group as well as focusing on and facilitating future actions and strategies. The report contains a summary of the issues raised by the SWOT as well...

  8. Internal evaluation report

    DEFF Research Database (Denmark)

    Sørensen, Birgitte Holm; Meyer, Bente; Levinsen, Karin

    It is the aim of this report to assess and evaluate the internal communication and management of the Lancelot project during the first year of the project's life (October 2005- October 2006). The report focuses on these issues through the perspective of a SWOT analysis carried out by the project...... members at the interim meeting in Manchester October 6-8. The SWOT analysis was chosen for its ability to identify problem areas within an organisation or group as well as focusing on and facilitating future actions and strategies. The report contains a summary of the issues raised by the SWOT as well...

  9. USSR Report, International Affairs

    Science.gov (United States)

    1987-05-06

    NOTAS SOBRE LA ECONOMIA Y EL DESARROLLO. Santiago de Chile , 1985, No 424/425, p 10. 11. For more detail see: LATINSKAYA AMERIKA, No 5, 1984. 12...3.0 $billion. REVISTA DE LA CEPAL. Santiago de Chile , 1983, No 20, 21; INTERNATIONAL HERALD TRIBUNE. Paris, 25 June 1984. 7. EC0N0MIA DE AMERICA...34 The items in the anthology des - cribe in detail the means and methods of the special services—that secret legion of imperialism which makes active use

  10. International Journal of Health Research

    African Journals Online (AJOL)

    Erah

    The International Journal of Health Research is an online international ... The journal welcomes original research papers, reviews and case reports on ..... mediator generated by endothelial cells, ... Springer Science and Business Media,.

  11. Internationalism in Education for Librarianship

    Science.gov (United States)

    Carroll, Frances Laverne

    1972-01-01

    International understanding and the advancement of knowledge are the two goals that are thought to be both quantitatively and qualitatively desirable as goal statements for internationalism in library science. (68 references) (MM)

  12. International Journal of Health Research

    African Journals Online (AJOL)

    Erah

    The International Journal of Health Research is an online international journal ... The journal is devoted to the promotion of health sciences and related disciplines (including medicine, pharmacy, nursing, biotechnology, cell and molecular ...

  13. Single Sign On Internal (SSOi)

    Data.gov (United States)

    Department of Veterans Affairs — Provides single sign-on solution for internal facing VA applications. Allows internal users access to a variety of VA systems and applications using a reduced set of...

  14. International Journal of Health Research

    African Journals Online (AJOL)

    Erah

    The International Journal of Health Research is an online international journal ... research papers, reviews and case reports on current topics of special ... formulated as Gastroretentive Drug Delivery System ...... In vivo gastric studies were run.

  15. Learning Activities for International Business.

    Science.gov (United States)

    Haynes, Thomas

    1998-01-01

    The National Standards for Business Education include nine areas relating to international business: awareness, communication, environmental factors, ethics, finance, management, marketing, import/export, and organizational structure of international business. (SK)

  16. The international hydrocoin project

    International Nuclear Information System (INIS)

    1988-01-01

    The international co-operation project HYDROCOIN for studying groundwater flow modelling in the context of radioactive waste disposal was initiated in 1984. Thirteen organizations from ten countries and two international organizations participate in the project which is managed by the Swedish Nuclear Power Inspectorate SKI. This report summarizes the results from the first phase of HYDROCOIN. Level 1, which has been devoted to verification of 29 computer programs for groundwater hydrology. This has been done by applying the codes to seven hypothetical test cases representing different physical situations. For linear test cases, the agreement between results calculated with different codes has been satisfactory for primarily calculated entities (groundwater pressure, salt concentration and temperatures). Results for properties derived from gradients of the primary field (groundwater velocity and trajectories) show agreement to a lesser extent. Furthermore, HYDROCOIN Level 1 illustrates problems related to solving strongly non-linear cases, such as coupled flow and brine transport. HYDROCOIN Level 1 has provided an efficient means for testing strengths and weaknesses of various strategies for groundwater flow modelling and post processing. As a result of the Level 1 effort, several code enhancements have been made

  17. International energy outlook 1998

    International Nuclear Information System (INIS)

    1998-04-01

    The International Energy Outlook 1998 (IEO98) presents an assessment by the Energy Information Administration (EIA) of the outlook for international energy markets through 2020. Projections in IEO98 are displaced according to six basic country groupings. The industrialized region includes projections for four individual countries -- the United States, Canada, Mexico, and Japan -- along with the subgroups Western Europe and Australasia (defined as Australia, New Zealand, and the US Territories). The developing countries are represented by four separate regional subgroups: developing Asia, Africa, Middle East, and Central and South America. China and India are represented in developing Asia. New to this year's report, country-level projections are provided for Brazil -- which is represented in Central and South America. Eastern Europe and the former Soviet Union (EE/FSU) are considered as a separate country grouping. The report begins with a review of world trends in energy demand. Regional consumption projections for oil, natural gas, coal, nuclear power, and renewable energy (hydroelectricity, geothermal, wind, solar, and other renewables) are presented in five fuel chapters, with a review of the current status of each fuel on a worldwide basis. Summary tables of the IEO98 projections for world energy consumption, carbon emissions, oil production, and nuclear power generating capacity are provided in Appendix A. 88 figs., 77 tabs

  18. International Nuclear Physics Conference

    CERN Document Server

    2016-01-01

    We are pleased to announce that the 26th International Nuclear Physics Conference (INPC2016) will take place in Adelaide (Australia) from September 11-16, 2016. The 25th INPC was held in Firenze in 2013 and the 24th INPC in Vancouver, Canada, in 2010. The Conference is organized by the Centre for the Subatomic Structure of Matter at the University of Adelaide, together with the Australian National University and ANSTO. It is also sponsored by the International Union of Pure and Applied Physics (IUPAP) and by a number of organisations, including AUSHEP, BNL, CoEPP, GSI and JLab. INPC 2016 will be held in the heart of Adelaide at the Convention Centre on the banks of the River Torrens. It will consist of 5 days of conference presentations, with plenary sessions in the mornings, up to ten parallel sessions in the afternoons, poster sessions and a public lecture. The Conference will officially start in the evening of Sunday 11th September with Registration and a Reception and will end late on the afternoon of Fri...

  19. International trade and environment

    International Nuclear Information System (INIS)

    Posada, Luis Guillermo

    1998-01-01

    The international trade conventional theory not only continues being supported upon the classic principle of comparative advantage, but also, in response to the rationality inherent to the traditional economic system, al so neglects considering the biophysical conditions under which transable goods are produced. The linkage of environment to trade is a recent concern, and it is explained on the basis that the first one has become a barrier for the second one. The environmental cause defenders, so as the free market advocates, are exposing their arguments in a context in which not necessarily to build viable solutions to the conflict is possible. The world economy behavior and tendencies do not offer the conditions needed so as that the official thesis in which the GATT - Rio - WTO thought can be summarized and the positive linkage towards the environmental quality, explicitly claimed by that thesis, becomes reality. Form these considerations, it is argument in this article in the direction of establishing a new international trade pattern and also some ideas are presented as to its characterization ecological economic view

  20. International Clean Energy Coalition

    Energy Technology Data Exchange (ETDEWEB)

    Erin Skootsky; Matt Gardner; Bevan Flansburgh

    2010-09-28

    In 2003, the National Association of Regulatory Utility Commissioners (NARUC) and National Energy Technology Laboratories (NETL) collaboratively established the International Clean Energy Coalition (ICEC). The coalition consisting of energy policy-makers, technologists, and financial institutions was designed to assist developing countries in forming and supporting local approaches to greenhouse gas mitigation within the energy sector. ICEC's work focused on capacity building and clean energy deployment in countries that rely heavily on fossil-based electric generation. Under ICEC, the coalition formed a steering committee consisting of NARUC members and held a series of meetings to develop and manage the workplan and define successful outcomes for the projects. ICEC identified India as a target country for their work and completed a country assessment that helped ICEC build a framework for discussion with Indian energy decisionmakers including two follow-on in-country workshops. As of the conclusion of the project in 2010, ICEC had also conducted outreach activities conducted during United Nations Framework Convention on Climate Change (UNFCCC) Ninth Conference of Parties (COP 9) and COP 10. The broad goal of this project was to develop a coalition of decision-makers, technologists, and financial institutions to assist developing countries in implementing affordable, effective and resource appropriate technology and policy strategies to mitigate greenhouse gas emissions. Project goals were met through international forums, a country assessment, and in-country workshops. This project focused on countries that rely heavily on fossil-based electric generation.

  1. Overview of international teledermatology

    Directory of Open Access Journals (Sweden)

    Karen McKoy

    2010-07-01

    Full Text Available Teledermatology is essentially “dermatology at a distance”, using one of many communication technologies to expand the reach of a dermatologist to those in need of their specialized knowledge. Most international teledermatology is store-and-forward in nature, a method in which images are stored on a computer and then transmitted electronically to a consulting dermatologist. This system is more convenient and less costly than real-time teledermatology. This review will focus on several of the store-and-forward teledermatology systems being developed and utilized successfully internationally. This discussion of “who” is practicing teledermatology is not comprehensive, but attempts to show some of the breadth of teledermatology practice around the world, including government national health plans, commercial endeavors, and charitable work by individuals and institutions. The goal in many instances is to provide better health outcomes through increased access, efficiency, and/or cost-effectiveness. More studies ultimately need to be conducted to develop a more comprehensive and sustainable model for teledermatology.

  2. OBJECTIF SCIENCES INTERNATIONAL

    CERN Multimedia

    Objectif Sciences International

    2010-01-01

    OBJECTIF SCIENCES INTERNATIONAL SEJOURS DE VACANCES SCIENTIFIQUES Concilier loisirs de vacances et investigations scientifiques, voilà la recette magique de l'ONG « Objectif Sciences International » qui donne la possibilité aux amateurs de sciences de 7 à 99 ans de participer à des Programmes de Recherche dédiés au Développement Durable. Les Congés Science Solidaire proposés par l'association pour les adultes émanent directement des préoccupations des populations locales pour la préservation de leur patrimoine environnemental. Les besoins et les objectifs sont définis avec les acteurs locaux pour assurer la réalisation de nos missions sur place. En cliquant sur le lien ci-dessous, vous pourrez découvrir plus en détails la liste des thèmes et destinations proposées pour ...

  3. International mussel watch

    International Nuclear Information System (INIS)

    Farrington, J.W.; Tripp, B.W.

    1993-01-01

    Deliberate and inadvertent discharges of chemical contaminants of environmental concern to the world's coastal ocean will continue for the foreseeable future, as human population increases and human habitation intensifies in the coastal zone worldwide. The goal of the International Mussel Watch Project is to provide an assessment of the status and trends of chemical contaminants in the world's coastal waters. These data are critical for protecting both the health of people who consume seafood and the health of coastal ecosystems. The International Mussel Watch Project is a global-scale monitoring program based on the concept of a sentinel organism capable of detecting trends in concentrations of several important marine contaminants. These included chlorinated pesticides, fossil-fuel hydrocarbons, and radionuclides from the nuclear fuel cycle and nuclear weapons testing fallout. Since the 1970's, scientists of several countries have been using common bivalve organisms, such as the blue mussels and oysters, to monitor chemical contaminants in coastal waters. Bivalve mollusks are good monitors for several reasons that include their ability to bioconcentrate the chemical contaminants of interest and their sedentary nature, which makes them representative of a specific place

  4. International petroleum statistics report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    The International Petroleum Statistics Report presents data on international oil production, demand, imports, exports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1994; OECD stocks from 1973 through 1994; and OECD trade from 1984 through 1994.

  5. International petroleum statistics report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The International Petroleum Statistics Report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. Word oil production and OECD demand data are for the years 1970 through 1995; OECD stocks from 1973 through 1995; and OECD trade from 1985 through 1995.

  6. Understanding Lustre Internals

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Feiyi [ORNL; Oral, H Sarp [ORNL; Shipman, Galen M [ORNL; Drokin, Oleg [ORNL; Wang, Di [ORNL; Huang, He [ORNL

    2009-04-01

    Lustre was initiated and funded, almost a decade ago, by the U.S. Department of Energy (DoE) Office of Science and National Nuclear Security Administration laboratories to address the need for an open source, highly-scalable, high-performance parallel filesystem on by then present and future supercomputing platforms. Throughout the last decade, it was deployed over numerous medium-to-large-scale supercomputing platforms and clusters, and it performed and met the expectations of the Lustre user community. As it stands at the time of writing this document, according to the Top500 list, 15 of the top 30 supercomputers in the world use Lustre filesystem. This report aims to present a streamlined overview on how Lustre works internally at reasonable details including relevant data structures, APIs, protocols and algorithms involved for Lustre version 1.6 source code base. More importantly, it tries to explain how various components interconnect with each other and function as a system. Portions of this report are based on discussions with Oak Ridge National Laboratory Lustre Center of Excellence team members and portions of it are based on our own understanding of how the code works. We, as the authors team bare all responsibilities for all errors and omissions in this document. We can only hope it helps current and future Lustre users and Lustre code developers as much as it helped us understanding the Lustre source code and its internal workings.

  7. International energy outlook 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The International Energy Outlook 1998 (IEO98) presents an assessment by the Energy Information Administration (EIA) of the outlook for international energy markets through 2020. Projections in IEO98 are displaced according to six basic country groupings. The industrialized region includes projections for four individual countries -- the United States, Canada, Mexico, and Japan -- along with the subgroups Western Europe and Australasia (defined as Australia, New Zealand, and the US Territories). The developing countries are represented by four separate regional subgroups: developing Asia, Africa, Middle East, and Central and South America. China and India are represented in developing Asia. New to this year`s report, country-level projections are provided for Brazil -- which is represented in Central and South America. Eastern Europe and the former Soviet Union (EE/FSU) are considered as a separate country grouping. The report begins with a review of world trends in energy demand. Regional consumption projections for oil, natural gas, coal, nuclear power, and renewable energy (hydroelectricity, geothermal, wind, solar, and other renewables) are presented in five fuel chapters, with a review of the current status of each fuel on a worldwide basis. Summary tables of the IEO98 projections for world energy consumption, carbon emissions, oil production, and nuclear power generating capacity are provided in Appendix A. 88 figs., 77 tabs.

  8. Internal Audit and Risk Management

    OpenAIRE

    Constantin Nicolae Vasile; Alexandru Georgiana

    2011-01-01

    Internal audit and risk management have the same goal: the control of risk. There are various roles for the internal audit in respect of risk management. The main limitations of internal audit in respect of risk management regards assuming risk management tasks. One of the main issues regarding risk management is to make sure that the key risks are taken into consideration and that the management and the board of the organization take action as needed. Internal audit could give advice to mana...

  9. International cooperation in nuclear safety

    International Nuclear Information System (INIS)

    Rosen, M.

    1991-01-01

    The mechanisms of international co-operations, co-ordinated by International Atomic Energy Agency, are presented. These co-operations are related to international safety standards, to the safety of the four hundred existing reactors in operation, to quick help and information in case of emergency, and to the already valid international conventions. The relation between atomic energy and environmental protection is also discussed briefly. (K.A.)

  10. Canada and international financial institutions

    OpenAIRE

    Robert Lafrance; James Powell

    1996-01-01

    International financial institutions, such as the International Monetary Fund, the World Bank and the Bank for International Settlements, are important players in the global financial system. This article provides an overview of the major international financial institutions to which Canada belongs. The paper highlights their activities and the nature of Canada's involvement, including that of the Bank of Canada. Recent initiatives coming out of the Halifax and Lyon Summits to improve the eff...

  11. Hanford internal dosimetry program manual

    International Nuclear Information System (INIS)

    Carbaugh, E.H.; Sula, M.J.; Bihl, D.E.; Aldridge, T.L.

    1989-10-01

    This document describes the Hanford Internal Dosimetry program. Program Services include administrating the bioassay monitoring program, evaluating and documenting assessments of internal exposure and dose, ensuring that analytical laboratories conform to requirements, selecting and applying appropriate models and procedures for evaluating internal radionuclide deposition and the resulting dose, and technically guiding and supporting Hanford contractors in matters regarding internal dosimetry. 13 refs., 16 figs., 42 tabs

  12. REFLECTIONS ON PRODUCTION INTERNALIZATION AND ITS INTERNATIONAL TRADE IMPLICATIONS

    Directory of Open Access Journals (Sweden)

    CLIPA RALUCA IRINA

    2014-06-01

    Full Text Available Vertically-integrated multinational companies place the different stages of production and marketing chain in different countries, looking for advantages such as low production costs, lower taxes, abundant resources and so on, while benefiting from the advantages of economies of scale, control of supplies or outlets. In fact, this vertical integration of multinational companies has led to the expansion of intra-firm trade and "internalized" operations, thus creating their own markets for the vertically-integrated production. Internationally active firms operate in a way that replaces the different functions of an open market with internal transactions, i.e. intra-firm transactions, whenever internal transaction costs are lower than the open-market ones. The direct consequence over international trade is the increase of intra-firm share of trade flows to one third of world trade, those companies making a suppression of international market segments that act in favour of an internal market. The creation of a multinational market and the enhancement of intra-firm trade have profound quantitative and qualitative implications on the composition, geographic orientation and dynamics of international trade. This paper deals with the issue of production internalization, with an overview of the main contributions made to the theory of internalization, while tackling its relative dimension. However, we intend to highlight the implications of this phenomenon on international trade. The work methodology falls within the range of qualitative approaches: logical argumentation, critical theoretical analysis.

  13. Quantifying Nanoparticle Internalization Using a High Throughput Internalization Assay.

    Science.gov (United States)

    Mann, Sarah K; Czuba, Ewa; Selby, Laura I; Such, Georgina K; Johnston, Angus P R

    2016-10-01

    The internalization of nanoparticles into cells is critical for effective nanoparticle mediated drug delivery. To investigate the kinetics and mechanism of internalization of nanoparticles into cells we have developed a DNA molecular sensor, termed the Specific Hybridization Internalization Probe - SHIP. Self-assembling polymeric 'pHlexi' nanoparticles were functionalized with a Fluorescent Internalization Probe (FIP) and the interactions with two different cell lines (3T3 and CEM cells) were studied. The kinetics of internalization were quantified and chemical inhibitors that inhibited energy dependent endocytosis (sodium azide), dynamin dependent endocytosis (Dyngo-4a) and macropinocytosis (5-(N-ethyl-N-isopropyl) amiloride (EIPA)) were used to study the mechanism of internalization. Nanoparticle internalization kinetics were significantly faster in 3T3 cells than CEM cells. We have shown that ~90% of the nanoparticles associated with 3T3 cells were internalized, compared to only 20% of the nanoparticles associated with CEM cells. Nanoparticle uptake was via a dynamin-dependent pathway, and the nanoparticles were trafficked to lysosomal compartments once internalized. SHIP is able to distinguish between nanoparticles that are associated on the outer cell membrane from nanoparticles that are internalized. This study demonstrates the assay can be used to probe the kinetics of nanoparticle internalization and the mechanisms by which the nanoparticles are taken up by cells. This information is fundamental for engineering more effective nanoparticle delivery systems. The SHIP assay is a simple and a high-throughput technique that could have wide application in therapeutic delivery research.

  14. Licensing Process for International Projects

    International Nuclear Information System (INIS)

    Raetzke, Christan

    2014-01-01

    Christan Raetzke, lawyer, then outlined why nuclear constructions were always international projects and in which cases it would make sense to also make the licensing process be international. His law consulting firm CONLAR focuses specifically on design review so he could adequately present why an international process would make a lot of sense without being a loss of sovereignty

  15. Internal Displacement: Livelihood saving responses

    OpenAIRE

    Deborah Hines

    2001-01-01

    Deborah Hines explores how to assist the internally displaced and those prone to displacement. She considers the major causes of internal displacement, making the case for a more comprehensive set of policy and operational actions in response to situations of internal displacement. Development (2001) 44, 34–39. doi:10.1057/palgrave.development.1110289

  16. International control of nuclear materials

    International Nuclear Information System (INIS)

    Koponen, Hannu

    1989-01-01

    Nuclear materials are subject to both national and international safeguards control. The International Atomic Energy Agency (IAEA) takes care of the international safeguards control. The control activities, which are discussed in this article, are carried out according to the agreements between various countries and the IAEA

  17. Language and the International Context

    Science.gov (United States)

    Tonkin, Humphrey

    1977-01-01

    A discussion of the issue of unilinguism and linguistic pluralism on the international scene. The need for international communication where English is the dominant force and efforts to preserve cultural equality are seen as compelling reasons for promotion of an international language such as Esperanto. (AMH)

  18. Internationalism and Our "Strenuous Family."

    Science.gov (United States)

    Ashworth, Mary

    1991-01-01

    Explores the concept of internationalism within the context of teaching English as a Second Language, arguing that, in spite of diverse perspectives, instructors can unite internationally to advocate literacy and language education, protect multiculturalism, and support international goals. (16 references) (CB)

  19. Twentieth Century Internationalism in Law

    DEFF Research Database (Denmark)

    Spiermann, Ole

    2007-01-01

    , i.e., doubt and insecurity about international law and its basis. Rather than facilitating international law as a practical discipline, a superfi cial understanding of internationalism reinforced fetishisms of the discipline's theoretical past, not least the axiom that states only are proper...

  20. Causation and International State Responsibility

    NARCIS (Netherlands)

    Castellanos-Jankiewicz, L.

    2012-01-01

    This work studies causation in the law of international State responsibility. It is submitted that the absence of causation as an element of the internationally wrongful act owes more to the structure of international law, than to the inadequateness of causation as a conceptual and legal construct

  1. Review of Hanford international activities

    International Nuclear Information System (INIS)

    Panther, D.G.

    1993-01-01

    Hanford initiated a review of international activities to collect, review, and summarize information on international environmental restoration and waste management initiatives considered for use at Hanford. This effort focused on Hanford activities and accomplishments, especially international technical exchanges and/or the implementation of foreign-developed technologies

  2. International School of Nuclear Law

    International Nuclear Information System (INIS)

    Anon.

    2004-01-01

    This is a report about the fourth International School of Nuclear Law (ISNL) held in Montpellier, France, on 23 August to 3 September 2004 by the OECD Nuclear Energy Agency (NEA) and the University of Montpellier 1 with the support of the International Nuclear Law Association (INLA), the European Commission, and the International Atomic Energy Agency (IAEA). (orig.)

  3. International fashion franchise in Finland

    OpenAIRE

    Vu, Phuong

    2015-01-01

    The study concentrates on exploring international clothing franchise and particularly international clothing franchise in Finland. The main objective of the research is to discover obstacles Finnish franchisees encounter when bringing an international fashion franchise to Finland and recommendations that are beneficial to their success. The thesis is inclined to exploit aspects concerning franchisees’ perspectives. In the literature review, main concepts presented are franchising, franchi...

  4. Simulation in International Relations Education.

    Science.gov (United States)

    Starkey, Brigid A.; Blake, Elizabeth L.

    2001-01-01

    Discusses the educational implications of simulations in international relations. Highlights include the development of international relations simulations; the role of technology; the International Communication and Negotiation Simulations (ICONS) project at the University of Maryland; evolving information technology; and simulating real-world…

  5. Teaching international animal agriculture.

    Science.gov (United States)

    Lukefahr, S D

    1999-11-01

    Students who major in animal science at U.S. institutions are generally exposed to a curriculum that emphasizes commercial, large-scale production of the few traditional food animals: cattle, poultry, sheep, and swine. Globally, most farmers live in lesser-developed countries under limited-resource conditions of land, feed supplies, equipment, and capital. The promotion of commercial animal production enterprises may not be appropriate for such farms because it can subject farmers to considerable economic risk. Rather, use of limited numbers of large livestock, locally adapted breeds, or smaller livestock (e.g., ducks, goats, guinea pigs, and rabbits) may be more appropriate under subsistence, integrated farming systems. In this global context, a course in international animal agriculture has been taught for 15 yr to undergraduate and graduate students. The course consists of a review of traditional and potential livestock species well suited for impoverished families on small farms and methods to implement sustainable livestock projects, including feasibility, design, implementation, monitoring, and evaluation stages. To enhance student understanding, global food issues and challenges are illustrated with case studies. A term paper is also assigned for which students choose three suitable livestock species or local breeds that would be complementary on a small crop farm (< 5 ha). Daily dietary requirements of protein and energy per family member are calculated. Itemized enterprise budgets and production tables are prepared. Early in the course, the general consensus of students was that people who are malnourished and live in poverty have low personal ambition and motivation, and that their problems should be amenable to solution by application of American technology and expertise. The course modifies such attitudes and enhances a student's critical thinking and problem-solving abilities and communication skills. Course evaluations indicated that students believed

  6. INTERNATIONAL DECOMMISSIONING SYMPOSIUM 2000

    Energy Technology Data Exchange (ETDEWEB)

    M.A. Ebadian, Ph.D.

    2001-01-01

    The purpose of IDS 2000 was to deliver a world-class conference on applicable global environmental issues. The objective of this conference was to publicize environmental progress of individual countries, to provide a forum for technology developer and problem-holder interaction, to facilitate environmental and technology discussions between the commercial and financial communities, and to accommodate information and education exchange between governments, industries, universities, and scientists. The scope of this project included the planning and execution of an international conference on the decommissioning of nuclear facilities, and the providing of a business forum for vendors and participants sufficient to attract service providers, technology developers, and the business and financial communities. These groups, when working together with attendees from regulatory organizations and government decision-maker groups, provide an opportunity to more effectively and efficiently expedite the decommissioning projects.

  7. Control Techtronics International

    Energy Technology Data Exchange (ETDEWEB)

    West, J.

    1995-12-31

    Polish graded coal can be burned in existing stoker boilers and meet the 1998 Air Quality standard. This is accomplished with the Control Techtronics microprocessor-based combustion controller accurately and repeatedly: (a) matching the combustion air to the coal firing rate, with continuous stack sensor feedback; (b) continuously varying the boiler`s firing rate based on output water temperature or steam pressure; (c) continuously varying the exhaust fan`s speed to maintain minimum negative pressure in the boiler`s combustion chamber; and recirculating a portion of the flue gas, at varying amounts throughout the boiler`s firing rate. Systems for five boilers have been installed and are operating on MPEC`s Balicka plant in Krakow. Control Techtronics International has $10 million of U.S. Export-Import Bank funds available for similar projects throughout Poland.

  8. International, intersectoral, or unobservable?

    DEFF Research Database (Denmark)

    Mitze, Timo; Naveed, Amjad; Ahmad, Nisar

    2016-01-01

    for these methodical advances when estimating sectoral knowledge production functions for OECD countries under weak and strong cross-sectional dependence. By doing so, we are able to uncover technology- and trade-related R&D spillover channels associated with social returns to R&D, while effectively controlling......In the theoretical and empirical growth literature, private and social returns to R&D have been identified as the key drivers of productivity gains and economic development. However, recently the debate on the relative importance of private vis-à-vis social returns has been reinforced...... for other types of productivity spillovers and latent macroeconomic shocks. Our results highlight the role played by international-intersectoral R&D spillovers for the social rate of return to R&D, while we get limited evidence for private returns to R&D once cross-sectional dependence is properly accounted...

  9. Joint International Accelerator School

    CERN Multimedia

    CERN Accelerator School

    2014-01-01

    The CERN and US Particle Accelerator Schools recently organised a Joint International Accelerator School on Beam Loss and Accelerator Protection, held at the Hyatt Regency Hotel, Newport Beach, California, USA from 5-14 November 2014. This Joint School was the 13th in a series of such schools, which started in 1985 and also involves the accelerator communities in Japan and Russia.   Photo courtesy of Alfonse Pham, Michigan State University.   The school attracted 58 participants representing 22 different nationalities, with around half from Europe and the other half from Asia and the Americas. The programme comprised 26 lectures, each of 90 minutes, and 13 hours of case study. The students were given homework each day and had an opportunity to sit a final exam, which counted towards university credit. Feedback from the participants was extremely positive, praising the expertise and enthusiasm of the lecturers, as well as the high standard and quality of their lectures. Initial dis...

  10. NOMA 2013 International Workshop

    CERN Document Server

    Fournier-Prunaret, Danièle; Nishio, Yoshifumi; Grácio, Clara

    2015-01-01

    In the field of Dynamical Systems, nonlinear iterative processes play an important role. Nonlinear mappings can be found as immediate models for many systems from different scientific areas, such as engineering, economics, biology, or can also be obtained via numerical methods permitting to solve non-linear differential equations. In both cases, the understanding of specific dynamical behaviors and phenomena is of the greatest interest for scientists. This volume contains papers that were presented at the International Workshop on Nonlinear Maps and their Applications (NOMA 2013) held in Zaragoza, Spain, on September 3-4, 2013. This kind of collaborative effort is of paramount importance in promoting communication among the various groups that work in dynamical systems and networks in their research theoretical studies as well as for applications. This volume is suitable for graduate students as well as researchers in the field.

  11. International regulatory activities

    International Nuclear Information System (INIS)

    Anon.

    1999-01-01

    The 43 rd Session of the IAEA General Conference was held in Vienna from 27 September to 1 October 1999 with delegations from 11 member states and representatives of various international organisations in attendance. Resolutions were adopted inter alia in the following areas: nuclear radiation and waste safety; strengthening IAEA technical co-operation; strengthening the IAEA's safeguards system; safeguards in the democratic people's republic of Korea; non proliferation safeguards in the middle east; illicit trafficking in nuclear materials and nuclear inspections in Iraq. The second part deals with the regulation laying down detailed rules for the application of the 1990 regulation on imports of agricultural products originating in third countries following the Chernobyl accident and recommendation on a classification system for solid radioactive waste. (A.L.B.)

  12. International Logistics Science Conference

    CERN Document Server

    Hompel, Michael; Meier, J

    2014-01-01

    The importance of logistics in all its variations is still increasing. New technologies emerge, new planning methods and algorithms are developed, only to face a market with a growing complexity and the need of weighting monetary costs against ecological impact. Mastering these challenges requires a scientific viewpoint on logistics, but always with applications in mind. This volume presents up-to-date logistics research in all its diversity and interconnectedness. It grew out of the “International Logistics Science Conference” (ILSC) held in Dortmund in September 2013, bringing together leading scientists and young academics from nine different countries. The conference was jointly organized by the “Efficiency Cluster Logistics” and the “Fraunhofer Institute for Material Flow and Logistics”. The Program Committee used a double blind review process to choose the 12 strongest contributions, which were then grouped in four areas: - Sustainability logistics, including electric mobility, smart inform...

  13. The International Linear Collider

    Directory of Open Access Journals (Sweden)

    List Benno

    2014-04-01

    Full Text Available The International Linear Collider (ILC is a proposed e+e− linear collider with a centre-of-mass energy of 200–500 GeV, based on superconducting RF cavities. The ILC would be an ideal machine for precision studies of a light Higgs boson and the top quark, and would have a discovery potential for new particles that is complementary to that of LHC. The clean experimental conditions would allow the operation of detectors with extremely good performance; two such detectors, ILD and SiD, are currently being designed. Both make use of novel concepts for tracking and calorimetry. The Japanese High Energy Physics community has recently recommended to build the ILC in Japan.

  14. The International Linear Collider

    Science.gov (United States)

    List, Benno

    2014-04-01

    The International Linear Collider (ILC) is a proposed e+e- linear collider with a centre-of-mass energy of 200-500 GeV, based on superconducting RF cavities. The ILC would be an ideal machine for precision studies of a light Higgs boson and the top quark, and would have a discovery potential for new particles that is complementary to that of LHC. The clean experimental conditions would allow the operation of detectors with extremely good performance; two such detectors, ILD and SiD, are currently being designed. Both make use of novel concepts for tracking and calorimetry. The Japanese High Energy Physics community has recently recommended to build the ILC in Japan.

  15. The internal percolation problem

    International Nuclear Information System (INIS)

    Bezsudnov, I.V.; Snarskii, A.A.

    2010-01-01

    The internal percolation problem (IP) as a new type of the percolation problem is introduced and investigated. In spite of the usual (or external) percolation problem (EP) when the percolation current flows from the top to the bottom of the system, in IP case the voltage is applied through bars which are present in the hole located within the system. The EP problem has two major parameters: M-size of the system and a 0 -size of inclusions, bond size, etc. The IP problem holds one parameter more: size of the hole L. Numerical simulation shows that the critical indexes of conductance for the IP problem are very close to those in the EP problem. On the contrary, the indexes of the relative spectral noise density of 1/f noise and higher moments differ from those in the EP problem. The basics of these facts is discussed.

  16. Entropy of international trades

    Science.gov (United States)

    Oh, Chang-Young; Lee, D.-S.

    2017-05-01

    The organization of international trades is highly complex under the collective efforts towards economic profits of participating countries given inhomogeneous resources for production. Considering the trade flux as the probability of exporting a product from a country to another, we evaluate the entropy of the world trades in the period 1950-2000. The trade entropy has increased with time, and we show that it is mainly due to the extension of trade partnership. For a given number of trade partners, the mean trade entropy is about 60% of the maximum possible entropy, independent of time, which can be regarded as a characteristic of the trade fluxes' heterogeneity and is shown to be derived from the scaling and functional behaviors of the universal trade-flux distribution. The correlation and time evolution of the individual countries' gross-domestic products and the number of trade partners show that most countries achieved their economic growth partly by extending their trade relationship.

  17. International organizations as orchestrators

    CERN Document Server

    Abbott, Kenneth W

    2015-01-01

    International Organizations as Orchestrators reveals how IOs leverage their limited authority and resources to increase their effectiveness, power, and autonomy from states. By 'orchestrating' intermediaries - including NGOs - IOs can shape and steer global governance without engaging in hard, direct regulation. This volume is organized around a theoretical model that emphasizes voluntary collaboration and support. An outstanding group of scholars investigate the significance of orchestration across key issue areas, including trade, finance, environment and labor, and in leading organizations, including the GEF, G20, WTO, EU, Kimberley Process, UNEP and ILO. The empirical studies find that orchestration is pervasive. They broadly confirm the theoretical hypotheses while providing important new insights, especially that states often welcome IO orchestration as achieving governance without creating strong institutions. This volume changes our understanding of the relationships among IOs, nonstate actors and sta...

  18. International Conference UMC 2013

    CERN Document Server

    Hübner, Wolfgang; Rasing, Theo; Chantrell, Roy

    2015-01-01

    This volume on Ultrafast Magnetism is a collection of articles presented at the international “Ultrafast Magnetization Conference” held at the Congress Center in Strasbourg, France, from October 28th to November 1st, 2013. This first conference, which is intended to be held every two years, received a wonderful attendance and gathered scientists from 27 countries in the field of Femtomagnetism, encompassing many theoretical and experimental research subjects related to the spins dynamics in bulk or nanostructured materials. The participants appreciated this unique opportunity for discussing new ideas and debating on various physical interpretations of the reported phenomena. The format of a single session with many oral contributions as well as extensive time for poster presentations allowed researchers to have a detailed overview of the field. Importantly, one could sense that, in addition to studying fundamental magnetic phenomena, ultrafast magnetism has entered in a phase where applied physics and eng...

  19. EVOLVE 2014 International Conference

    CERN Document Server

    Tantar, Emilia; Sun, Jian-Qiao; Zhang, Wei; Ding, Qian; Schütze, Oliver; Emmerich, Michael; Legrand, Pierrick; Moral, Pierre; Coello, Carlos

    2014-01-01

    This volume encloses research articles that were presented at the EVOLVE 2014 International Conference in Beijing, China, July 1–4, 2014.The book gathers contributions that emerged from the conference tracks, ranging from probability to set oriented numerics and evolutionary computation; all complemented by the bridging purpose of the conference, e.g. Complex Networks and Landscape Analysis, or by the more application oriented perspective. The novelty of the volume, when considering the EVOLVE series, comes from targeting also the practitioner’s view. This is supported by the Machine Learning Applied to Networks and Practical Aspects of Evolutionary Algorithms tracks, providing surveys on new application areas, as in the networking area and useful insights in the development of evolutionary techniques, from a practitioner’s perspective. Complementary to these directions, the conference tracks supporting the volume, follow on the individual advancements of the subareas constituting the scope of the confe...

  20. An international perspective

    International Nuclear Information System (INIS)

    Skinner, R.

    2004-01-01

    Recent developments in the oil markets were reviewed in order to examine the international context for energy policy and challenges. The main elements and trends in global energy supply and demand were also reviewed along with the issues they present. Oil markets and energy supply industries in North America are influenced by industry consolidation, regulatory reform and oil pricing. Grid-based industries have been the main target of market reform policies. This presentation examined the world energy outlook in terms of fossil fuel use, demand growth in developing countries, energy security, and how to reduce greenhouse gases. It was noted that in addition to energy efficiency and renewable energy sources, unconventional oil from Canada's oil sands will appear in the oil business scene. The author emphasized that a key policy goal will be the removal of barriers to investment in energy supplies. figs

  1. The International multilateral relationships

    International Nuclear Information System (INIS)

    Asty, M.; Lacoste, A.C.; Gauvain, J.; Scherrer, J.; Baer, A.J.; Thiebaud, Ph.; Delattre, D.; Domaratzki, Z.; Pretre, S.; Serviere, G.; Currie, J.; Martin, A.; Bye, R.; Williams, L.; Lacoste, A.C.

    2000-01-01

    Great multilateral organizations, at the end of the fifties to promote nuclear energy for peaceful uses, made structures in charge of promoting the exchanges in the field of safety. The Safety Authority takes part in numerous activities of these organisms with the double objective to know the practices of other ones and to make their own practices known. However, its limited means oblige to make choices among these ones that are proposed, on taking into account the specificities of each organism and on seeing not to be implied in promoting activities for nuclear energy. After the Chernobyl accident, the international community needed to conclude incentive conventions reminding of the liabilities of states in matter of nuclear safety. The first meeting of contracting parts at the Convention on nuclear safety in april 1999 has shown the high level of opening in which the countries considered their obligations. (N.C.)

  2. COMPUTING: International symposium

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    Recent Developments in Computing, Processor, and Software Research for High Energy Physics, a four-day international symposium, was held in Guanajuato, Mexico, from 8-11 May, with 112 attendees from nine countries. The symposium was the third in a series of meetings exploring activities in leading-edge computing technology in both processor and software research and their effects on high energy physics. Topics covered included fixed-target on- and off-line reconstruction processors; lattice gauge and general theoretical processors and computing; multiprocessor projects; electron-positron collider on- and offline reconstruction processors; state-of-the-art in university computer science and industry; software research; accelerator processors; and proton-antiproton collider on and off-line reconstruction processors

  3. International RILEM Symposium

    CERN Document Server

    Birgisson, Björn; Frost, David; Wang, Linbing

    2013-01-01

    The micro- and nano-modification of infrastructure materials and the associated multi-scale characterization and simulation has the potential to open up whole new uses and classes of materials, with wide-ranging implications for society. The use of multi-scale characterization and simulation brings the ability to target changes at the very small scale that predictably effect the bulk behavior of the material and thus allowing for the optimization of material behavior and performance.   The International RILEM Symposium on Multi-Scale Modeling and Characterization of Infrastructure Materials (Stockholm, June 10-12, 2013) brought together key researchers from around the world to present their findings and ongoing research in this field in a focused environment with extended discussion times. From asphalt to concrete, from chemistry to mechanics, from nano- to macro-scale: the collection of topics covered by the Symposium represents the width and depth of the currently ongoing efforts of developing more sustain...

  4. International EUREKA: Initialization Segment

    International Nuclear Information System (INIS)

    1982-02-01

    The Initialization Segment creates the starting description of the uranium market. The starting description includes the international boundaries of trade, the geologic provinces, resources, reserves, production, uranium demand forecasts, and existing market transactions. The Initialization Segment is designed to accept information of various degrees of detail, depending on what is known about each region. It must transform this information into a specific data structure required by the Market Segment of the model, filling in gaps in the information through a predetermined sequence of defaults and built in assumptions. A principal function of the Initialization Segment is to create diagnostic messages indicating any inconsistencies in data and explaining which assumptions were used to organize the data base. This permits the user to manipulate the data base until such time the user is satisfied that all the assumptions used are reasonable and that any inconsistencies are resolved in a satisfactory manner

  5. The international Chernobyl project

    International Nuclear Information System (INIS)

    Gonzalez, A.J.

    1992-01-01

    The findings of the International Chernobyl Project are summarized herewith. The project focused on four key issues related to the radiological consequences of the Chernobyl accident which are of concern to the population and policy makers: the true extent of the current contamination in inhabited areas of Belarus, Russia and the Ukraine; the past, current and future radiation exposure of the population; the actual and potential health effects; and the adequacy or measures being taken to protect the public. The project findings are expected to contribute towards alleviating the consequences of the accident by presenting factual information to allow future policy and worldwide assistance to be channelled to where it is most needed and where it can be best used. (author)

  6. International Environmental Institute

    International Nuclear Information System (INIS)

    DiSibio, R.R.

    1992-01-01

    The International Environmental Institute is being established at the Hanford Site to provide training and education in environmental restoration and waste management technologies and to serve as an interface for exchange of information among government laboratories, regional and federal governments, universities, and US industries. Recognized as the flagship of the nation's environmental management effort, the Hanford Site provides a unique living environmental laboratory that represents the most extensive, complex, and diverse cleanup challenges anywhere. An Environmental Institute director has been selected, the organizational structure has been established, and initial phases of operation have begun. The combined resources of the Hanford Site and the Environmental Institute offer unprecedented technological capabilities for dealing with the nation's environmental issues

  7. International Multidisciplinary Microscopy Congress

    CERN Document Server

    Oral, Ahmet; Ozer, Mehmet; InterM; INTERM2013

    2014-01-01

    The International Multidisciplinary Microscopy Congress (INTERM2013) was organized on October 10-13, 2013. The aim of the congress was to bring together scientists from various branches to discuss the latest advances in the field of microscopy. The contents of the congress have been broadened to a more "interdisciplinary" scope, so as to allow all scientists working on related subjects to participate and present their work. These proceedings include 39 peer-reviewed technical papers, submitted by leading academic and research institutions from over 12 countries and representing some of the most cutting-edge research available. The 39 papers are grouped into the following sections: - Applications of Microscopy in the Physical Sciences - Applications of Microscopy in the Biological Sciences

  8. International venture capital perspective

    International Nuclear Information System (INIS)

    Carter, D.

    2004-01-01

    'Full text:' The emerging fuel cell industry is characterized by global cooperation and partnerships in commercial, technical, and financial aspects. In this talk, we would like to provide observations about international venture capital focused on fuel cells globally. The talk will refer to experiences Conduit Ventures has had with its portfolio companies and other investors in various countries. We discuss our approach to working with portfolio companies who are geographically remote from our main office in London. We also discuss the process of making investment decisions on possible investments in various countries. The talk will conclude with insights and 'lessons learned' which may be of interest to fellow members of Fuel Cells Canada. (author)

  9. International energy indicators

    International Nuclear Information System (INIS)

    Rossi, E. Jr.

    1981-12-01

    Data are tabulated and graphically represented on international energy indicators. The following are presented: world crude oil production, 1974 to October 1981; OPEC crude oil productive capacity; world crude oil and refined product inventory levels, 1975 to October, 1981; oil consumption in OECD countries, 1975 to October 1981; USSR crude oil production and exports, 1975 to October, 1981; free world and US nuclear electricity generation, 1973 to December, 1981 and current capacity. Specific US data presented are: US domestic oil supply, 1977 to June, 1981; US gross imports of crude oil and products, 1973 to October, 1981; landed cost of Saudi crude current and 1974 dollars; US coal trade, 1975 to September, 1981; US natural gas trade, 1975 to October, 1981; summary of US merchandise trade, 1977 to October, 1981; and energy/GNP ratio

  10. International regulatory activities

    International Nuclear Information System (INIS)

    Anon.

    2003-01-01

    Among international regulatory activities we find resolutions adopted by the IAEA general conference (2003), through European Union we find proposals for directives on nuclear safety and radioactive waste management, new regulation on the application of EURATOM safeguards, control of high activity sealed radioactive sources, recommendation on the protection and information of the public with regard to the continued contamination of certain wild food products following the Chernobyl accident, proposals for decisions authorizing the Member states to sign and ratify the Protocol to amend the Paris convention, p)proposals for a directive on environment liability with regard to the prevention and remedying of environmental damage, proposal of a regulation on the law applicable to non-contractual obligation. (N.C.)

  11. Internal Ocean Waves

    Science.gov (United States)

    2006-01-01

    Internal waves are waves that travel within the interior of a fluid. The waves propagate at the interface or boundary between two layers with sharp density differences, such as temperature. They occur wherever strong tides or currents and stratification occur in the neighborhood of irregular topography. They can propagate for several hundred kilometers. The ASTER false-color VNIR image off the island of Tsushima in the Korea Strait shows the signatures of several internal wave packets, indicating a northern propagation direction. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet. ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products. The broad spectral coverage and high spectral resolution of ASTER provides scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance. The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate. Size: 60 by 120 kilometers (37.2 by 74.4 miles) Location: 34.6 degrees North latitude, 129.5 degrees East longitude Orientation: North at top Image Data: ASTER bands 3, 2, and 1 Original Data Resolution: 90

  12. International law and United Nations

    Directory of Open Access Journals (Sweden)

    Savić Matej

    2012-01-01

    Full Text Available Along with centuries-lasting open military pretensions of world superpowers, modern diplomacy has developed, as beginning a war, as well as coming to peace demanded political activity which resulted, first in signing, and then coming into effect of international documents, on the basis of which, a foundation for the modern international order has been cast. Further on, by the formation of international organizations, codification has been allowed, as well as a progressive development of international law. Additionally, in the sense of preserving international peace and security, first the League of Nations was formed, and following the ending of World War II, the UN. Generally, the functioning of the United Nation's organs, has been regulated by legal rules, however political goals, tendencies, and mechanisms which the member states are using determine greatly the activity above all of the Security Council, but furthermore of the General Assembly, as a plenary organ. Nevertheless, the achieved results of the Commission for International Law in the meaning of creation of international conventions, as well as state adhering to the same, present unassailable achievements in the sense of development of international law. On the other hand, tendencies of motion of international relationships are aimed at establishing a multi-polar system in the international community. Today, the political scene is assuming a new appearance, by which the nearly built international system is already awaiting further progressive development.

  13. The International Active Learning Space

    DEFF Research Database (Denmark)

    Manners, Ian James

    2015-01-01

    -Danish students receive the basic international and intercultural skills and knowledge they need in current society. The English-language masters’ seminars I teach at the Department of Political Science are international in terms of students and teacher, but they are also Active Learning seminars......-Danish students (and sometimes teachers) rarely speak to each other or learn each other’s names. In the international AL spaces I create, students must work together on joint tasks which require interaction to address tasks and integration in order to benefit from the multinational activity groups. Planning AL...... that complete the seminar soon become vocal advocates of international AL. Ultimately, enriching student learning through immersing Danish and international students in an international AL space is, for me, the best way of ensuring an internationalised learning outcome, rather than just international mobility....

  14. 75 FR 19944 - International Code Council: The Update Process for the International Codes and Standards

    Science.gov (United States)

    2010-04-16

    ... documents from ICC's Chicago District Office: International Code Council, 4051 W Flossmoor Road, Country... Energy Conservation Code. International Existing Building Code. International Fire Code. International...

  15. International research centre launched

    International Nuclear Information System (INIS)

    1965-01-01

    Full text: The first scientific research and educational institution to be set up on a completely international basis was officially inaugurated in Trieste on 5 October 1964 by the Director General of IAEA, Dr. Sigvard Eklund, when he opened the first seminar of the International Centre for Theoretical Physics. As evidence of the international nature of the institution he noted that the scientists who would work and teach there during the first year represented sixteen different countries. By the end of 1964, the Centre building was nearing completion and three of the five floors were occupied. A successful symposium had been held on the subject of plasma physics, and a score of professors and fellows were at work, from Bulgaria, Czechoslovakia, Greece, India, Japan, Jordan, the Netherlands, Norway, Pakistan, Poland, the United Kingdom, and the United States. A dozen scientific papers had been issued as preprints. The main purpose of the Centre is to foster the advancement of theoretical physics through training and research; at first the chief subject will be high-energy and elementary particle physics. Plasma physics, low energy physics and solid-state physics will also be dealt with. Special attention is paid to the needs of the developing countries. Of the 25 fellows selected for the academic year 1964-65, more than half are from South America, Africa and Asia. In conjunction with the Research Centre, there is an Advanced School for theoretical Physics to provide graduate training for fellows who need such preparation before they embark upon research. The Centre works under the guidance of a Scientific Council comprising the president, Prof. M. Sandoval-Vallarta (Nuclear Energy Commission of Mexico); Prof. A. Abragam (Saclay, France); Prof. R. Oppenheimer (Institute for Advanced Study, Princeton, USA); Dr. V. Soloviev (Dubna, USSR); Prof V.F. Weiskopf (Director General, CERN) ; Prof Abdus Salam (Imperial College, London) ; Prof. P. Budini (University of Trieste

  16. International guidance activities

    International Nuclear Information System (INIS)

    Richardson, Allan C.B.

    1989-01-01

    International principles for setting Protective Action Guides (PAGs) are contained in two key documents that contain identical statements. One is Publication Number 40 of the ICRP, which was issued in 1985. The title is 'Protection of the Public in the Event of Major Radiation Accidents, Principles for Planning'. The other is the IAEA's Safety Series Publication Number 72, also issued in 1985, written by many of the same authors and titled, 'Principles for Establishing Intervention Levels'. The principles that were set forth in these documents were identical, were incomplete, and they are, unfortunately, the only principles that are now in effect, while proposed revisions go through one draft after another. There are several such draft revisions that are of significance. The most important is that of the ICRP. The basic guidance that applies to most planned exposure to radiation is ICRP Publication 26. That document has been under revision by the Commission for a number of years, and the new version will, for the first time, include recommendations for emergency response. They are now getting close to closure, and I think it should be a very much improved and useful document. But it isn't finished yet. Such guidance doesn't get developed in a vacuum, and there have been a couple of parallel efforts which have provided significant input to the ICRP, which is essentially a behind-closed-doors effort. These other efforts are more open. One of these is being carried out within the IAEA, which has convened annual meetings of national experts for a number of years in Vienna, to generate a replacement for Safety Series No. 72, mentioned earlier. There is a meeting scheduled this December to complete this effort; and, hopefully, we will reach closure at that meeting on at least the basic principles. The Nuclear Energy Agency (NEA) has also been at work. It has convened a group of experts from member nations that have been developing recommendations. There is an overlap

  17. International red meat trade.

    Science.gov (United States)

    Brester, Gary W; Marsh, John M; Plain, Ronald L

    2003-07-01

    The maturation of the US beef and pork markets and increasing consumer demands for convenience, safety, and nutrition suggests that the beef and pork industries must focus on product development and promotion. New marketing arrangements are developing that help coordinate production with consumer demands. The relative high levels of incomes in the United States are likely to increase the demands for branded products rather than increase total per capita consumption. Foreign markets represent the greatest opportunity for increased demand for commodity beef and pork products. Increasing incomes in developing countries will likely allow consumers to increase consumption of animal-source proteins. Real prices of beef and pork have declined substantially because of sagging domestic demand and increasing farm-level production technologies. Increasing US beef and pork exports have obviated some of the price declines. Pork attained a net export position from a quantity perspective in 1995. The United States continues to be a net importer of beef on a quantity basis but is close to becoming a net exporter in terms of value. By-products continue to play a critical role in determining the red meat trade balance and producer prices. The United States, however, must continue to become cost, price, and quality competitive with other suppliers and must secure additional market access if it is to sustain recent trade trends. Several trade tensions remain in the red meat industry. For example, mandated COOL will undoubtedly have domestic and international effects on the beef and pork sectors. Domestically, uncertainty regarding consumer demand responses or quality perceptions regarding product origin, as well as added processor-retailer costs will be nontrivial. How these factors balance out in terms of benefits versus costs to the industry is uncertain. From an international perspective, some beef and pork export suppliers to the United States could view required labeling as a

  18. CTBTO international cooperation workshop

    International Nuclear Information System (INIS)

    1999-01-01

    The International Cooperation Workshop took place in Vienna, Austria, on 16 and 17 November 1998, with the participation of 104 policy/decision makers, Research and Development managers and diplomatic representatives from 58 States Signatories to the Comprehensive Nuclear-Test Ban Treaty (CTBT). The Workshop attempted to develop Treaty stipulations to: promote cooperation to facilitate and participate in the fullest possible exchange relating to technologies used in the verification of the Treaty; enable member states to strengthen national implementation of verification measures, and to benefit from the application of such technologies for peaceful purposes. The potential benefits arising from the CTBT monitoring, analysis and data communication systems are multifaceted, and as yet unknown. This Workshop provided the opportunity to examine some of these possibilities. An overview of the CTBT verification regime on the general aspects of the four monitoring technologies (seismic, hydro-acoustic, infrasound and radionuclides), including some of the elements that are the subject of international cooperation, were presented and discussed. Questions were raised on the potential benefits that can be derived by participating in the CTBT regime and broad-based discussions took place. Several concrete proposals on ways and means to facilitate and promote cooperation among States Signatories were suggested. The main points discussed by the participants can be summarized as follows: the purpose of the CTBT Organization is to assist member states to monitor Treaty compliance; the CTBT can be a highly effective technological tool which can generate wide-ranging data, which can be used for peaceful purposes; there are differences in the levels of technology development in the member states that is why peaceful applications should be supported by the Prep Com for the benefit of all member states, whether developed or developing, training being a key element to optimize the CTBT

  19. Impacts of Culture on International Negotiations

    Science.gov (United States)

    Goodin, James Ronald

    2010-09-01

    This paper provides practical suggestions for developing a healthy and complete working relationship between the system safety practitioner and international business partners, international vendors and international customers.

  20. Ketamine and international regulations.

    Science.gov (United States)

    Liao, Yanhui; Tang, Yi-Lang; Hao, Wei

    2017-09-01

    Ketamine is an anesthetic commonly used in low-income countries and has recently been shown to be effective for treatment-resistant depression. However, the illicit manufacturing, trafficking, and nonmedical use of ketamine are increasing globally, and its illicit use poses major public health challenges in many countries. To review the nonmedical use of ketamine in selected countries and its regulatory control. We conducted a review of literature identified from searches of the China National Knowledge Infrastructure (CNKI) (1979-2016) and PubMed databases, supplemented by additional references identified by the authors. Special attention was given to the regulation of ketamine. Illicit manufacturing, trafficking, and use of ketamine appear to have begun on a large scale in several Asian nations, and it has subsequently spread to other regions. Regulations governing availability of ketamine vary across countries, but there is a clear trend toward tighter regulations. As nonmedical use of ketamine and its harmful consequences have worsened globally, stricter controls are necessary. Appropriate regulation of ketamine is important for international efforts to control ketamine's cross-border trafficking and its nonmedical use.

  1. International exploration by independents

    International Nuclear Information System (INIS)

    Bertagne, R.G.

    1991-01-01

    Recent industry trends indicate that the smaller US independents are looking at foreign exploration opportunities as one of the alternatives for growth in the new age of exploration. It is usually accepted that foreign finding costs per barrel are substantially lower than domestic because of the large reserve potential of international plays. To get involved overseas requires, however, an adaptation to different cultural, financial, legal, operational, and political conditions. Generally foreign exploration proceeds at a slower pace than domestic because concessions are granted by the government, or are explored in partnership with the national oil company. First, a mid- to long-term strategy, tailored to the goals and the financial capabilities of the company, must be prepared; it must be followed by an ongoing evaluation of quality prospects in various sedimentary basins, and a careful planning and conduct of the operations. To successfully explore overseas also requires the presence on the team of a minimum number of explorationists and engineers thoroughly familiar with the various exploratory and operational aspects of foreign work, having had a considerable amount of onsite experience in various geographical and climatic environments. Independents that are best suited for foreign expansion are those that have been financially successful domestically, and have a good discovery track record. When properly approached foreign exploration is well within the reach of smaller US independents and presents essentially no greater risk than domestic exploration; the reward, however, can be much larger and can catapult the company into the big leagues

  2. International exploration by independent

    International Nuclear Information System (INIS)

    Bertragne, R.G.

    1992-01-01

    Recent industry trends indicate that the smaller U.S. independents are looking at foreign exploration opportunities as one of the alternatives for growth in the new age of exploration. Foreign finding costs per barrel usually are accepted to be substantially lower than domestic costs because of the large reserve potential of international plays. To get involved in overseas exploration, however, requires the explorationist to adapt to different cultural, financial, legal, operational, and political conditions. Generally, foreign exploration proceeds at a slower pace than domestic exploration because concessions are granted by a country's government, or are explored in partnership with a national oil company. First, the explorationist must prepare a mid- to long-term strategy, tailored to the goals and the financial capabilities of the company; next, is an ongoing evaluation of quality prospects in various sedimentary basins, and careful planning and conduct of the operations. To successfully explore overseas also requires the presence of a minimum number of explorationists and engineers thoroughly familiar with the various exploratory and operational aspects of foreign work. Ideally, these team members will have had a considerable amount of on-site experience in various countries and climates. Independents best suited for foreign expansion are those who have been financially successful in domestic exploration. When properly approached, foreign exploration is well within the reach of smaller U.S. independents, and presents essentially no greater risk than domestic exploration; however, the reward can be much larger and can catapult the company into the 'big leagues.'

  3. The international hydrocoin project

    International Nuclear Information System (INIS)

    1987-01-01

    The International HYDROCOIN (Hydrologic Code Intercomparison) Project was started in May 1984. Fourteen organizations participate in the Project, with the Swedish Nuclear Power Inspectorate (SKI) as managing participant and the OECD Nuclear Energy Agency (NEA) taking part as a member of the Project secretariat. HYDROCOIN is concerned with the assessment of groundwater movements at potential nuclear waste disposal sites with the help of mathematical models and computer codes. The Project is divided into three levels. The objective of HYDROCOIN Level 1 is to verify the accuracy of groundwater flow codes. HYDROCOIN Level 2 and Level 3 are concerned with validation of hydrological models and uncertainty/sensitivity analysis, respectively. This report, which has been prepared by the NEA Secretariat and SKI in consultation with the co-ordinating group of the HYDROCOIN Project summarizes the background and objectives of the Project and presents the results of the work performed up to the middle of 1987. It is intended to provide general information on HYDROCOIN to interested parties beyond the group of directly involved specialists

  4. International Conference Medical Radiations

    International Nuclear Information System (INIS)

    2010-01-01

    Full text : The second edition of the international conference Medical radiation : research and applications which took place in Marrakech (Morocco) from 7 to 9 April 2010, was designed to bring together researchers and physicians from different countries who dedicated their talents and time to this endeavour. The conference's program defined goals were is to identify the most reliable techniques among the several tested so far and to establish the most practical standardized methodologies, taking into account such recent technological development in radiation medical research. The scientific objectives of this conference are as follows : present the state of the art of the various topics of the congress, give a progress report on the impact of the interaction of the various scientific and technical disciplinary fields (Medicine, Biology, Mathematics, Physics,..) on the applications of radiations in medicine, promote the interdisciplinary efforts of research among researchers, present new technologies and research and development tasks prepared in the field of medical radiations, contribute to the emergence of new ideas of research and development of new collaborations [fr

  5. International leadership in nursing

    Directory of Open Access Journals (Sweden)

    Ged F. Williams

    2013-12-01

    Full Text Available As the global community becomes overwhelmed by conflict, threat and scandal in many countries it is heartening to find that many of us can still find opportunity to give generously to the betterment of humanity.Recently we have both had our share of fun and excitement working and learning in various regions of the world, Ged in the Middle East and Africa and Wilson in the USA, The Netherlands and Brazil.We are often asked “how do you develop an international perspective”? The short answer is that it is an insidious accident sometimes, however like many things a deeper analysis reveals a journey that is often planned and other times blessed by unexpected surprises. However a sense of openness, generosity and adventure is always necessary to maximise every opportunity.Among other things, Ged allocated time to travel and to visit hospitals and nurses in other parts of Australia and the world, listening to people’s stories, dreams, and aspirations and providing reciprocal encouragement and fellowship, often through interpreters. (Rev Cuid 2013; 4(1:433-6.

  6. International breeder reactor development

    International Nuclear Information System (INIS)

    Traube, K.

    1976-01-01

    For more than a decade, sodium cooled breeder reactors have now been in the focus of advanced nuclear power development in the major industrialized countries. In the sixties, a total of seven small experimental nuclear power stations were commissioned. Two of these have been shut down in the meantime, the others continue to work satisfactorily, their main purpose being the development of fuel elements. The years 1972-1974 saw the commissioning of the prototype power stations in the 300 MWe power category in France, the United Kingdom and the Soviet Union. Presently, other experimental reactors are under construction in the Federal Republic of Germany, Italy, Japan, the United States, plus another Soviet 600 MWe prototype reactor and the SNR 300 DeBeNeLux prototype at Kalkar. A comparison of the technological features either implemented or planned in the prototype and experimental power plants and of their fuel elements reveals a remarkable similarity in the basic concepts pursued in different countries. The two types of breeder reactors, viz. the loop and the pool types, show a closer resemblance to each other than do pressurized and boilling water reactors. The growing awareness of administrative problems emerging in the approaching phase of the introduction of large breeder power stations in a number of European countries has recently led to a streamlining effort in the structure of industries and to tentative steps towards international cooperation on a broad basis. (orig.) [de

  7. Dutch radiodiagnostics viewed internationally

    International Nuclear Information System (INIS)

    Valois, J.C. de

    1990-01-01

    Dutch radiodiagnostics viewed internationally. - A quantitative description of diagnostic radiology is given in terms of radiological density (the number of radiological examinations per 1000 inhibitants), consumptions of roentgen film and contrast media. The data concerning examinations were recorded by a yearly inquiry system addressing all Dutch radiologists. The consumption of film and contrast media were derived from the data banks of the industries. In comparing these data with the data for Western Europe, Japan and the United States it is remarkable that diagnostic radiology scores lowest in regard to density, film consumption and use of contrast media. Only in the use of 35 mm cinefilm (coronary angiography) is The Netherlands number 2 on the list preceded by the United States. As a consequence radiation exposure of the population caused by diagnostic radiology is low in The Netherlands. Although the technical condition of the equipment is good due to regular and preventive service the life-span of the radiological equipment is gradually increasing beyond the limits of the normal economic depreciation. Growing arrears are found in the application of new technology: ultrasound, computer tomography and magnetic resonance imaging. The substitution of high osmolar contrast media by low osmolar media is also laggin gbehind. (author). 10 refs.; 1 fig.; 4 tab

  8. International nuclear technology transfer

    International Nuclear Information System (INIS)

    Cartwright, P.; Rocchio, J.P.

    1978-01-01

    Light water reactors (LWRs), originally developed in the United States, became the nuclear workhorses for utilities in Europe and Japan largely because the U.S. industry was willing and able to transfer its nuclear know-how abroad. In this international effort, the industry had the encouragement and support of the U.S. governement. In the case of the boiling water reactor (BWR) the program for technology transfer was developed in response to overseas customer demands for support in building local designs and manufacturing capabilities. The principal vehicles have been technology exchange agreements through which complete engineering and manufacturing information is furnished covering BWR systems and fuel. Agreements are held with companies in Germany, Japan, Italy, and Sweden. In recent years, a comprehensive program of joint technology development with overseas manufacturers has begun. The rapidly escalating cost of nuclear research and development make it desirable to minimize duplication of effort. These joint programs provide a mechanism for two or more parties jointly to plan a development program, assign work tasks among themselves, and exchange test results. Despite a slower-than-hoped-for start, nuclear power today is playing a significant role in the economic growth of some developing countries, and can continue to do so. Roughly half of the 23 free world nations that have adopted LWRs are developing countries

  9. International energy outlook 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This report presents international energy projections through 2020, prepared by the Energy Information Administration. The outlooks for major energy fuels are discussed, along with electricity, transportation, and environmental issues. The report begins with a review of world trends in energy demand. The historical time frame begins with data from 1970 and extends to 1996, providing readers with a 26-year historical view of energy demand. The IEO99 projections covers a 24-year period. The next part of the report is organized by energy source. Regional consumption projections for oil, natural gas, coal, nuclear power, and renewable energy (hydroelectricity, geothermal, wind, solar, and other renewables) are presented in the five fuel chapters, along with a review of the current status of each fuel on a worldwide basis. The third part of the report looks at energy consumption in the end-use sectors, beginning with a chapter on energy use for electricity generation. New to this year`s outlook are chapters on energy use in the transportation sector and on environmental issues related to energy consumption. 104 figs., 87 tabs.

  10. INTERNATIONAL TRADE WHITH RAPESEED

    Directory of Open Access Journals (Sweden)

    Radu Lucian PÂNZARU

    2013-01-01

    Full Text Available The study takes into consideration the international trade situation of rapeseed worldwide. To highlight the situation are analyzed sequentially imports and exports in five units continents: Africa, America, Asia, Europe and Oceania. Applicability and interest increased for trade with this product is emphasized by references from Romania. The study takes into consideration 2008-2010. In terms of world imports and their structure is noted preponderance Europe and Asia in the quantities imported - 87.38% (both, the weights low enough for Oceania and Africa - 0.04 together. If we analyze the situation of exports is apparent fact that Europe remains, as in the case of imports, the main player on the market (48.11%, but not followed by Asia, but of America with a very close relative weight (44 , 45%. Oceania owns more than 5% of world quantitatively of exports, while Asia and Africa have shares almost insignificant - 0.36 and 0.05% respectively. Regarding the situation of global trade balance exchanges for rapeseed can be seen a globally deficient character.

  11. INTERNATIONAL TRADE WITH ONIONS

    Directory of Open Access Journals (Sweden)

    Radu Lucian PÂNZARU

    2013-01-01

    Full Text Available The paper refers to the global trade situation with onion, 2008-2010. Besides presenting the existing situation of the five units continents (Africa, America, Asia, Europe and Oceania study shows worldwide level of imports and exports, as well as its contribution to the performing acts of international exchange. Quantitative aspects of trade are filled with values data, that allowed the preparation of trade exchanges for this product. The main importer (in quantitative terms is represented by Asia, followed by Europe and at greater distance by the America, while the value of imports was dominated by operations performed in Europe, Asia and America - weights of 39.7 , 38.1 and 18.6% respective (of the world total. Concerning the quantity, the major players on the market exports are represented by Asia and Europe. They have dominated the world market, achieving 45.6 and respective 30.8% of world exports. America ranks third with a share of 17.4%. In terms of value, world exports were dominated by Asia, Europe and America (33.5, 32.7 and respective 26.7%, with a downward trend in the share of Asia and increasing European weights and American (compared to the specific situation of the quantities exported

  12. International Evoked Potentials Symposium

    CERN Document Server

    1980-01-01

    The past decade has seen great progress in the measurement of evoked potentials in man; a steady increase in our understanding of their charac­ teristics, their origins and their usefulness; and a growing application in the field of clinical diagnosis. The topic is a truly multidisciplinary one. Important research contributions have been made by workers of many different backgrounds and clinical applications span the specialities. This book represents a revised and updated version of the work originally presented at the international evoked potential symposium held in Nottingham 4-6 1978. The Nottingham Symposium provided a forum for a state-of-the-art discussion amongst workers from many different disciplines and from many different countries. For each major topic in the field an expert review set the scene for discussion of current research presentations. This format is retained in the book: the chapters in Part A provide the context in which the research presented in Part B is set. The task of selecting m...

  13. Update in Internal Medicine

    Science.gov (United States)

    López-Jiménez, Francisco; Brito, Máximo; Aude, Y. Wady; Scheinberg, Phillip; Kaplan, Mariana; Dixon, Denise A.; Schneiderman, Neil; Trejo, Jorge F.; López-Salazar, Luis Humberto; Ramírez-Barba, Ector Jaime; Kalil, Roberto; Ortiz, Carmen; Goyos, José; Buenaño, Alvaro; Kottiech, Samer; Lamas, Gervasio A.

    2009-01-01

    More than 500,000 new medical articles are published every year and available time to keep updated is scarcer every day. Nowadays, the task of selecting useful, consistent, and relevant information for clinicians is a priority in many major medical journals. This review has the aim of gathering the results of the most important findings in clinical medicine in the last few years. It is focused on results from randomized clinical trials and well-designed observational research. Findings were included preferentially if they showed solid results, and we avoided as much as possible including only preliminary data, or results that included only non-clinical outcomes. Some of the most relevant findings reported here include the significant benefit of statins in patients with coronary artery disease even with mean cholesterol level. It also provides a substantial review of the most significant trials assessing the effectiveness of IIb/IIIa receptor blockers. In gastroenterology many advances have been made in the H. pylori eradication, and the finding that the cure of H. pylori infection may be followed by gastroesophageal reflux disease. Some new antivirals have shown encouraging results in patients with chronic hepatitis. In the infectious disease arena, the late breaking trials in anti-retroviral disease are discussed, as well as the new trends regarding antibiotic resistance. This review approaches also the role of leukotriene modifiers in the treatment of asthma and discusses the benefit of using methylprednisolone in patients with adult respiratory distress syndrome, among many other advances in internal medicine. PMID:11068074

  14. International Business Cycle

    Directory of Open Access Journals (Sweden)

    Marek Lubiński

    2007-04-01

    Full Text Available Prime stylized facts of international business cycle theory refer to positive correlation in the cyclical components of important macroeconomic variables across countries. However a number of indicators of business cycle synchronization do not point to clear trends. It can be ascribed to the fact that different forces influence level of business cycle correlation. When investigating into the forces behind the commonness in aggregate fluctuations economic research seems to have pointed in two directions. One strand of the literature examines the idea of common exogenous shocks that affect economies simultaneously. In addition to that economic interdependencies such as trade in goods and services or capital account transactions may serve as the channels through which disturbances spill over across countries.The observed degree of output co movement reflects both the nature of the shocks that have occurred and the degree of economic interdependence. In the periods when common shocks prevail level of synchronization is usually higher than in times of transmission dominance.

  15. International uranium market

    International Nuclear Information System (INIS)

    Neff, T.L.; Jacoby, H.D.

    1980-12-01

    Discussed in this report are 1) how one might think about uranium demand, resources and supply, 2) how producers and consumers see the market and are likely to behave, including specifics about export and import commitments, and 3) how these actors are brought together in the international market. The general conclusion is that much of current anxiety about future uranium supply results primarily from a brief but difficult period in the mid- to late-1970's; and that current conditions and trends are favorable (at least to consumers) that there is now little basis for concern. Inventories contractual positions and producer commitments--when compared with realistic (or even unrealistic) demand estimates--imply a buyer's market for at least the next decade. The result will be considerable increases in market flexibility and resilience to shock, and real prices that are low relative to those of the past few years. There is a need to reconsider assumptions about desired directions of technological development, for many current programs were planned in an era of pessimism about uranium supply and process. Similar questions must be raided about nonproliferation policies that depend on some level of control of fuel supplies by the industrial nations. With a soft and more diversified uranium market, leverage that may have existed in the past is rapidly being eroded. Finally, as world prices turn soft, there may be significant problems created for U.S. uranium producers, who have relatively high costs in relation to several large-scale foreign suppliers

  16. Guidelines for dynamic international programs

    International Nuclear Information System (INIS)

    Gold, M.A.

    1993-01-01

    Matters of global concern-deforestation, global warming, biodiversity loss, sustainable development, fuelwood crises, watershed destruction, and large-scale flooding-frequently involve forests and natural resources. In the future, university students will enter a global setting that more than ever depends on a strong knowledge of international issues. USA land-grant universities are attempting to prepare students for this challenge by improving their international programs including forestry. To improve university programs, several factors will need to be addressed and are discussed, with examples, in this article: commitment of the faculty; program specialization; geographic specialization; reward systems for international contributions; international collaboration; recycled dollars within the university; active teaching programs; research; extention and outreach; language training; international faculty; travel grants; twinning relationships with sister institutions; selective in pursuit of international development assistance; and study centers. 6 refs

  17. Globalization, Inequality & International Economic Law

    Directory of Open Access Journals (Sweden)

    Frank J. Garcia

    2017-04-01

    Full Text Available International law in general, and international economic law in particular, to the extent that either has focused on the issue of inequality, has done so in terms of inequality between states. Largely overlooked has been the topic of inequality within states and how international law has influenced that reality. From the perspective of international economic law, the inequality issue is closely entwined with the topics of colonialism and post-colonialism, the proper meaning of development, and globalization. While international economic law has undoubtedly contributed to the rise of inequality, it is now vital that the subject of international economic law be examined for how it may contribute to the lessening of inequality. To do so will require a shift in the way that we think, in order to address inequality as a problem of an emerging global market society, and how best to regulate that society and its institutions.

  18. International standards for radiation protection

    International Nuclear Information System (INIS)

    Ambrosi, P.

    2011-01-01

    International standards for radiation protection are issued by many bodies. These bodies differ to a large extent in their organisation, in the way the members are designated and in the way the international standards are authorised by the issuing body. Large differences also exist in the relevance of the international standards. One extreme is that the international standards are mandatory in the sense that no conflicting national standard may exist, the other extreme is that national and international standards conflict and there is no need to resolve that conflict. Between these extremes there are some standards or documents of relevance, which are not binding by any formal law or contract but are de facto binding due to the scientific reputation of the issuing body. This paper gives, for radiation protection, an overview of the main standards issuing bodies, the international standards or documents of relevance issued by them and the relevance of these documents. (authors)

  19. Internal auditors meet at CERN

    CERN Multimedia

    2008-01-01

    What does CERN have in common with INTERPOL? The answer: the challenge of managing a complex international organisation operating outside national regulations. Participants of the internal audit conference had the opportunity to visit ATLAS.On 17th &18th April CERN hosted a meeting for the Internal Audit Heads of some of the most famous international organisations in the world. Sixteen organisations were represented at the conference, including the European Commission, INTERPOL, the European Central Bank, the OECD, the European Space Agency (ESA), NATO and the European Organisation for Astronomical Research in the Southern Hemisphere (ESO). The objective of this annual meeting is to share best practices and benchmark performance in the fields of auditing, organizational governance, risk management and internal controls. International organisations, due to their specific legal status and the absence of applicable national legisl...

  20. International handling of fissionable material

    International Nuclear Information System (INIS)

    1975-01-01

    The opinion of the ministry for foreign affairs on international handling of fissionable materials is given. As an introduction a survey is given of the possibilities to produce nuclear weapons from materials used in or produced by power reactors. Principles for international control of fissionable materials are given. International agreements against proliferation of nuclear weapons are surveyed and methods to improve them are proposed. (K.K.)