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Sample records for voiding disorders related

  1. Nocturia: The circadian voiding disorder

    Directory of Open Access Journals (Sweden)

    Jin Wook Kim

    2016-05-01

    Full Text Available Nocturia is a prevalent condition of waking to void during the night. The concept of nocturia has evolved from being a symptomatic aspect of disease associated with the prostate or bladder to a form of lower urinary tract disorder. However, recent advances in circadian biology and sleep science suggest that it might be important to consider nocturia as a form of circadian dysfunction. In the current review, nocturia is reexamined with an introduction to sleep disorders and recent findings in circadian biology in an attempt to highlight the importance of rediscovering nocturia as a problem of chronobiology.

  2. Uroflowmetry in neurologically normal children with voiding disorders

    DEFF Research Database (Denmark)

    Jensen, K M; Nielsen, K.K.; Kristensen, E S

    1985-01-01

    of neurological deficits underwent a complete diagnostic program including intravenous urography, voiding cystography and cystoscopy as well as spontaneous uroflowmetry, cystometry-emg and pressure-flow-emg study. The incidence of dyssynergia was 22%. However, neither the flow curve pattern nor single flow...... variables were able to identify children with dyssynergia. Consequently uroflowmetry seems inefficient in the screening for dyssynergia in neurological normal children with voiding disorders in the absence of anatomical bladder outlet obstruction....

  3. Void Dynamics

    Science.gov (United States)

    Padilla, Nelson D.; Paz, Dante; Lares, Marcelo; Ceccarelli, Laura; Lambas, Diego Garcí A.; Cai, Yan-Chuan; Li, Baojiu

    2016-10-01

    Cosmic voids are becoming key players in testing the physics of our Universe.Here we concentrate on the abundances and the dynamics of voids as these are among the best candidatesto provide information on cosmological parameters. Cai, Padilla & Li (2014)use the abundance of voids to tell apart Hu & Sawicki f(R) models from General Relativity. An interestingresult is that even though, as expected, voids in the dark matter field are emptier in f(R) gravity due to the fifth force expellingaway from the void centres, this result is reversed when haloes are used to find voids. The abundance of voids in this casebecomes even lower in f(R) compared to GR for large voids. Still, the differences are significant and thisprovides a way to tell apart these models. The velocity field differences between f(R) and GR, on the other hand, arethe same for halo voids and for dark matter voids.Paz et al. (2013), concentrate on the velocity profiles around voids. First they show the necessityof four parameters to describe the density profiles around voids given two distinct voidpopulations, voids-in-voids and voids-in-clouds. This profile is used to predict peculiar velocities around voids,and the combination of the latter with void density profiles allows the construction of modelvoid-galaxy cross-correlation functions with redshift space distortions. When these modelsare tuned to fit the measured correlation functions for voids and galaxies in the SloanDigital Sky Survey, small voids are found to be of the void-in-cloud type, whereas largerones are consistent with being void-in-void. This is a novel result that is obtaineddirectly from redshift space data around voids. These profiles can be used toremove systematics on void-galaxy Alcock-Pacinsky tests coming from redshift-space distortions.

  4. A RELATION FOR THE VOID FRACTION OF RANDOMLY PACKED PARTICLE BEDS

    NARCIS (Netherlands)

    HOFFMANN, AC; FINKERS, HJ

    1995-01-01

    The void fractions of loosely packed and tapped beds of particles of continuous size distributions are correlated by means of a proposed new semi-empirical relation. In this relation four parameters describing the following particle properties are included: (i) mean particle size, (ii) spread of the

  5. Bed wetting - silent suffering: an approach to enuresis and voiding disorders in children.

    Science.gov (United States)

    Kanitkar, Madhuri; Ramamurthy, H Ravi

    2013-09-01

    Bed wetting or nocturnal enuresis is a common problem among children. It is either monosymptomatic or may be associated with a voiding disorder. Many factors may contribute towards enuresis such as developmental delay, heredity, inappropriate nocturnal anti diuretic hormone secretion and reduced bladder capacity. Any child presenting with bed-wetting should be evaluated for any underlying bladder dysfunction before labeling as monosymptomatic enuresis. The evaluation consists of structured bowel and bladder history, detailed clinical examination, frequency volume record and appropriate investigations. The frequency volume diary is an indispensible component of evaluation and helps in establishing diagnosis and tailoring therapy. The treatment of monosymptomatic enuresis consists of positive psychological support, alarms and medication (desmopressin/ anticholinergics/ imiprammine). Children with features of underlying bladder dysfunction, anatomical anomalies and neurological disorders should be referred to a pediatrician without delay. The outcome of therapy is usually rewarding but varies, depending on the underlying etiology, motivation, compliance and family support. The cure rates with alarms are better than with desmopressin in monosymptomatic enuresis. Timely and appropriate therapy yields better outcomes. Thus, a thorough, scientific and evidence based approach is essential in children presenting with bed-wetting.

  6. Void structure of concrete with superabsorbent polymers and its relation to frost resistance of concrete

    DEFF Research Database (Denmark)

    Hasholt, Marianne Tange; Jensen, Ole Mejlhede; Laustsen, Sara

    2013-01-01

    the difference between poor and satisfactory frost-resistance. Furthermore, the results indicate that voids created directly by SAP protect concrete against frost deterioration just like other air voids; if the concrete contains enough SAP voids, these alone can provide sufficient frost resistance. © 2013 RILEM....

  7. Parents Function and Behavioral Disorders in Children with and without Diurnal Voiding Dysfunction: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Parsa Yousefi

    2014-09-01

    Full Text Available Background: Diurnal voiding dysfunction is one of the most common causes of pediatric urology clinic admissions. It can cause behavioral problems for children and their parents. We lunch this study to compare the parents’ function and children’s behavior problem in pediatric patients suffering from diurnal voiding dysfunction referring Arak Amir Kabir hospital. Materials and Methods: To perform this case-control study, we recruit 116 children with diurnal voiding dysfunction and compared them with other 116 children non-affected children aged between 5 to 16 years old. The child behavior checklist (CBCL4/18 for children behavior assessment and Global Assessment of Functioning (GAF for the evaluation of their parent’s behavior was completed by the parents. Data was analyzed using ANOVA, qualitative variables and χ2 formula. Results: Among 116 patient with voiding dysfunction, 10 case (8.6% showed behavioral problem while this figure was 3 case (2.6% in the control group, denoting a significant difference (p=0.04. Moreover 20 children (17.2% in the case group and 9 children (7.8% in the control group had internalizing problem (p=0.02. Twenty two children (19% with voiding dysfunction and 8 children (6.9% in the healthy group had externalizing problem which was also a significant difference (p=0.01. As a significant difference (0.01, the parent’s average stress and behavior scores in case and control group were 3.65 and 3.76, respectively. Conclusion: The higher prevalence of behavioral problem in the children suffering from diurnal voiding dysfunction and their parent’s functional impairment highlights the importance of early parent’s intervention for early treatment and subsequently prevention of future behavioral problem in their sibling.

  8. Related Addictive Disorders.

    Science.gov (United States)

    Buck, Tina; Sales, Amos

    This paper provides an overview of addiction related to substance abuse. It provides basic information, prevalence, diagnostic criteria, assessment tools, and treatment issues for eating disorders, compulsive gambling, sex addictions, and work addictions. Eating disorders such as anorexia nervosa and bulimia nervosa, especially affect adolescents.…

  9. [Combined therapy of voiding irritative disorders after surgical treatment of benign prostatic hyperplasia with Andro-Gin].

    Science.gov (United States)

    Loran, O B; Luk'ianov, I V; Markov, A V

    2005-01-01

    The results of operative and rehabilitative treatment of benign prostatic hyperplasia (BPH) was analysed for 69 BPH patients with postoperative irritative disorders of voiding. The patients were divided into four groups by rehabilitative therapy: group 1 received antibacterial therapy; group 2--antibacterial therapy+alpha-adrenoblockers; group 3--antibacterial therapy+transrectal laser and magnetic physiotherapy; group 4--antibacterial therapy+alpha-adrenoblockers+transrectal laser and magnetic physiotherapy. The worst result was obtained in group 1, the best one in groups 3 and 4 (the response was compatible). Thus, the addition of physiotherapy to the complex of postoperative rehabilitation of patients operated for BPH is justified and provides treatment improvement.

  10. Partial discharge patterns related to surface deterioration in voids in epoxy

    DEFF Research Database (Denmark)

    Holbøll, Joachim; Henriksen, Mogens

    1990-01-01

    Results are presented from an investigation of the relationship between changes in partial discharge patterns and the surface deterioration process taking place in small naturally formed spherical voids in epoxy plastic. The voids were exposed to a moderate electric stress above inception level......, where partial discharges were present for more than 1500 h. Two types of electrical tree growth were found, the bush like tree and a single channel-like tree, which led to very different partial discharge patterns. It is concluded that the formation of crystals on a void surface leads to an immediate...

  11. Partial discharge patterns related to surface deterioration in voids in epoxy

    OpenAIRE

    Holbøll, Joachim; Henriksen, Mogens

    1990-01-01

    Results are presented from an investigation of the relationship between changes in partial discharge patterns and the surface deterioration process taking place in small naturally formed spherical voids in epoxy plastic. The voids were exposed to a moderate electric stress above inception level, where partial discharges were present for more than 1500 h. Two types of electrical tree growth were found, the bush like tree and a single channel-like tree, which led to very different partial disch...

  12. Pharmacotherapy in the Management of Voiding and Storage Disorders, Including Enuresis and Encopresis

    Science.gov (United States)

    Reiner, William G.

    2008-01-01

    Enuresis and encopresis are disorders of the bladder and rectum, and this article helps in understanding the neurobiology of lower urinary tract and anorectal function to help in the treatment of these disorders. Treatment for children with these disorders emphasizes either a psychological or pharmacological approach.

  13. [Sleep related eating disorder].

    Science.gov (United States)

    Inoue, Yuichi; Komada, Yoko

    2010-01-01

    Nighttime eating is categorized as either sleep-related eating disorder (SRED) or night eating syndrome (NES). Critical reviews of the literature on both disorders have suggested that they are situated at opposite poles of a disordered eating spectrum. The feeding behavior in SRED is characterized by recurrent episodes of eating after an arousal from nighttime sleep with amnesia. Conversely, NES could be considered as an abnormality in the circadian rhythm of meal timing with a normal circadian timing of sleep onset. Both conditions clearly concentrate to occur during young adulthood, and are often relentless and chronic. Misunderstanding and low awareness of SRED and NES have limited our ability to determine the exact prevalence of the two disorders. SRED is frequently associated with other sleep disorders, in particular parasomnias such as sleep walking. Cognitive-behavioral therapy is ineffective, but pharmacotherapy is very effective in controlling SRED. Especially, studies have shown that the anti-seizure medication topiramate may be an effective treatment for SRED.

  14. Biofeedback for nonneuropathic daytime voiding disorders in children: a systematic review and meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Fazeli, Mir Sohail; Lin, Yiqun; Nikoo, Nooshin; Jaggumantri, Sravan; Collet, Jean-Paul; Afshar, Kourosh

    2015-01-01

    Biofeedback has been used to treat children with symptoms of bladder dysfunction not responding to standard therapy alone. However, evidence of the effectiveness of biofeedback is scarce and is based on small studies. We conducted a systematic review of the literature to assess the effects of biofeedback as adjunctive therapy for symptoms of nonneuropathic voiding disorders in children up to age 18 years. We searched MEDLINE(®), Embase(®) and CENTRAL on the OvidSP(®) platform as well as conference proceedings for randomized trials presented at scientific conventions, symposia and workshops through August 13, 2013. Hand searches and review of reference lists of retrieved articles were also performed. Five eligible studies were included in the systematic review, of which 4 (382 participants) were pooled in the meta-analysis based on available outcomes data. The overall proportion of cases with resolved incontinence at month 6 was similar in the biofeedback and control groups (OR 1.37 [95% CI 0.64 to 2.93], RD 0.07 [-0.09, 0.23]). There was also no significant difference in mean maximum urinary flow rate (mean difference 0.50 ml, range -0.56 to 1.55) or likelihood of urinary tract infection (OR 1.30 [95% CI 0.65 to 2.58]). Current evidence does not support the effectiveness of biofeedback in the management of children with nonneuropathic voiding disorders. More high quality, randomized controlled trials are needed to better evaluate the effect of biofeedback. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  15. Menopause related sleep disorders.

    Science.gov (United States)

    Eichling, Philip S; Sahni, Jyotsna

    2005-07-15

    Sleep difficulty is one of the hallmarks of menopause. Following recent studies showing no cardiac benefit and increased breast cancer, the question of indications for hormonal therapy has become even more pertinent. Three sets of sleep disorders are associated with menopause: insomnia/depression, sleep disordered breathing and fibromyalgia. The primary predictor of disturbed sleep architecture is the presence of vasomotor symptoms. This subset of women has lower sleep efficiency and more sleep complaints. The same group is at higher risk of insomnia and depression. The "domino theory" of sleep disruption leading to insomnia followed by depression has the most scientific support. Estrogen itself may also have an antidepressant as well as a direct sleep effect. Treatment of insomnia in responsive individuals may be a major remaining indication for hormone therapy. Sleep disordered breathing (SDB) increases markedly at menopause for reasons that include both weight gain and unclear hormonal mechanisms. Due to the general under-recognition of SDB, health care providers should not assume sleep complaints are due to vasomotor related insomnia/depression without considering SDB. Fibromyalgia has gender, age and probably hormonal associations. Sleep complaints are almost universal in FM. There are associated polysomnogram (PSG) findings. FM patients have increased central nervous system levels of the nociceptive neuropeptide substance P (SP) and lower serotonin levels resulting in a lower pain threshold to normal stimuli. High SP and low serotonin have significant potential to affect sleep and mood. Treatment of sleep itself seems to improve, if not resolve FM. Menopausal sleep disruption can exacerbate other pre-existing sleep disorders including RLS and circadian disorders.

  16. A theoretical derivation of the transients related to partial discharges in ellipsoidal voids

    DEFF Research Database (Denmark)

    Crichton, George C; Karlsson, A.; Pedersen, Aage

    1988-01-01

    Transients associated with partial discharges in ellipsoidal and spheroidal voids are derived in terms of the induced charges on the electrode. The relationship between the induced charge and the properties which are usually measured are discussed. Formulas are obtained from which conclusions can...

  17. Geometry and scaling of cosmic voids

    CERN Document Server

    Gaite, Jose

    2008-01-01

    CONTEXT: Cosmic voids are observed in the distribution of galaxies and, to some extent, in the dark matter distribution. If these distributions have fractal geometry, it must be reflected in the geometry of voids; in particular, we expect scaling sizes of voids. However, this scaling is not well demonstrated in galaxy surveys yet. AIMS: Our objective is to understand the geometry of cosmic voids in relation to a fractal structure of matter. We intend to distinguish monofractal voids from multifractal voids, regarding their scaling properties. We plan to analyse voids in the distributions of mass concentrations (halos) in a multifractal and their relation to galaxy voids. METHODS: We make a statistical analysis of point distributions based on the void probability function and correlation functions. We assume that voids are spherical and devise a simple spherical void finder. For continuous mass distributions, we employ the methods of fractal geometry. We confirm the analytical predictions with numerical simula...

  18. Responsibility voids

    NARCIS (Netherlands)

    van Hees, M.V.B.P.M; Braham, Matthew

    We present evidence for the existence of 'responsibility voids' in committee decision-making, that is, the existence of situations where no member of a committee can individually be held morally responsible for the outcome. We analyse three types of reasons (causal, normative and epistemic) for the

  19. Attention Deficit-Hyperactivity Disorder Symptoms and Daytime Voiding Symptoms in Children with Primary Enuresis: An Observational Study to Evaluate the Effectiveness of Desmopressin Treatment

    Directory of Open Access Journals (Sweden)

    Teng-Kai Yang

    2015-01-01

    Full Text Available Purpose. To evaluate the effectiveness of presence of desmopressin in treating primary enuresis (PE for children with attention deficit-hyperactivity disorder (ADHD symptoms. Materials and Methods. Children aged from 5 to 12 years with the chief complaint of PE treated with desmopressin were enrolled in pediatric urology clinics. The parent-reported SNAP-IV questionnaire was used to evaluate ADHD symptoms (cut-off value: 90th percentile. Voiding symptoms were assessed by the Dysfunctional Voiding Scoring System (DVSS questionnaire. The responses to desmopressin were analyzed in children with and without ADHD symptoms. Results. The study sample comprised 68 children; 27 (39.7% presented with ADHD symptoms and 41 (60.3% with non-ADHD symptoms. The children collected from a tertiary referral center may explain the high prevalence of ADHD symptoms in the present study. The total DVSS score in the ADHD symptoms group was significantly higher than in the non-ADHD symptoms group (7.72 versus 5.65, P=0.05. In the ADHD symptoms group, there were significantly higher score in the “pee 1-2 times/day” and “can’t wait” subscales of DVSS and lower sleep quality based on the Pediatric Sleep Quality questionnaire, as well as significantly lower peak flow rate and voided volume. The responses to desmopressin for enuresis were comparable between children with ADHD and non-ADHD symptoms. Conclusions. Approximately 39.7% of PE children presented with ADHD symptoms at urologic clinics. PE children with ADHD symptoms had higher risk of daytime LUTS and comparable response to desmopressin treatment for PE. To evaluate ADHD symptoms and daytime voiding symptoms is important in children with PE.

  20. Work-related voice disorder

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo Przysiezny

    2015-04-01

    Full Text Available INTRODUCTION: Dysphonia is the main symptom of the disorders of oral communication. However, voice disorders also present with other symptoms such as difficulty in maintaining the voice (asthenia, vocal fatigue, variation in habitual vocal fundamental frequency, hoarseness, lack of vocal volume and projection, loss of vocal efficiency, and weakness when speaking. There are several proposals for the etiologic classification of dysphonia: functional, organofunctional, organic, and work-related voice disorder (WRVD.OBJECTIVE: To conduct a literature review on WRVD and on the current Brazilian labor legislation.METHODS: This was a review article with bibliographical research conducted on the PubMed and Bireme databases, using the terms "work-related voice disorder", "occupational dysphonia", "dysphonia and labor legislation", and a review of labor and social security relevant laws.CONCLUSION: WRVD is a situation that frequently is listed as a reason for work absenteeism, functional rehabilitation, or for prolonged absence from work. Currently, forensic physicians have no comparative parameters to help with the analysis of vocal disorders. In certain situations WRVD may cause, work disability. This disorder may be labor-related, or be an adjuvant factor to work-related diseases.

  1. Work-related voice disorder

    OpenAIRE

    Paulo Eduardo Przysiezny; Luciana Tironi Sanson Przysiezny

    2015-01-01

    INTRODUCTION: Dysphonia is the main symptom of the disorders of oral communication. However, voice disorders also present with other symptoms such as difficulty in maintaining the voice (asthenia), vocal fatigue, variation in habitual vocal fundamental frequency, hoarseness, lack of vocal volume and projection, loss of vocal efficiency, and weakness when speaking. There are several proposals for the etiologic classification of dysphonia: functional, organofunctional, organic, and work-related...

  2. Work related shoulder disorders

    DEFF Research Database (Denmark)

    Svendsen, Susanne Wulff; Bonde, Jens Peter; Mathiassen, S.E.

    2004-01-01

    Aims: To determine quantitative exposure-response relations between work with highly elevated arms and supraspinatus tendinitis, shoulder pain with disability, and shoulder pain without disability. Methods: A cross sectional study was conducted in a historical cohort of 1886 males from three...... occupational groups. Exposure measurements were performed for four consecutive working days in a random sample of 72 currently employed subjects. Individual work histories were obtained by questionnaire and register data. Health status was ascertained by physical examination blinded towards exposure...... and symptoms. Data were analysed by generalised estimating equation and multiple logistic regression with adjustment for potential confounders. Results: For current upper arm elevation above 90°, a duration increment of 1% of the daily working hours was associated with odds ratios of 1.23 (95% CI 1.10 to 1...

  3. Trichotillomania, stereotypic movement disorder, and related disorders.

    Science.gov (United States)

    Stein, Dan J; Garner, Joseph P; Keuthen, Nancy J; Franklin, Martin E; Walkup, John T; Woods, Douglas W

    2007-08-01

    Trichotillomania is currently classified as an impulse control disorder not otherwise classified, whereas body-focused behaviors other than hair-pulling may be diagnosed as stereotypic movement disorder. A number of disorders characterized by repetitive, body-focused behaviors (eg, skin-picking) are prevalent and disabling and may have phenomenological and psychobiological overlap. Such disorders deserve greater recognition in the official nosology, and there would seem to be clinical utility in classifying them in the same diagnostic category.

  4. Testing Gravity using Void Profiles

    Science.gov (United States)

    Cai, Yan-Chuan; Padilla, Nelson; Li, Baojiu

    2016-10-01

    We investigate void properties in f(R) models using N-body simulations, focusing on their differences from General Relativity (GR) and their detectability. In the Hu-Sawicki f(R) modified gravity (MG) models, the halo number density profiles of voids are not distinguishable from GR. In contrast, the same f(R) voids are more empty of dark matter, and their profiles are steeper. This can in principle be observed by weak gravitational lensing of voids, for which the combination of a spectroscopic redshift and a lensing photometric redshift survey over the same sky is required. Neglecting the lensing shape noise, the f(R) model parameter amplitudes fR0=10-5 and 10-4 may be distinguished from GR using the lensing tangential shear signal around voids by 4 and 8 σ for a volume of 1 (Gpc/h)3. The line-of-sight projection of large-scale structure is the main systematics that limits the significance of this signal for the near future wide angle and deep lensing surveys. For this reason, it is challenging to distinguish fR0=10-6 from GR. We expect that this can be overcome with larger volume. The halo void abundance being smaller and the steepening of dark matter void profiles in f(R) models are unique features that can be combined to break the degeneracy between fR0 and σ8.

  5. Computerized voiding diary.

    Science.gov (United States)

    Rabin, J M; McNett, J; Badlani, G H

    1993-01-01

    An electronic, computerized voiding diary, "Compu-Void" (patent pending) was developed in order to simplify, augment, and automate patients' recording of bladder symptomatology. A voiding diary as a tool has the potential to provide essential information for a more complete diagnostic and therefore therapeutic picture for each patient. Two major problems with the standard written voiding diary have been a lack of patient compliance and the limited amount of information it garners. Twenty-five women with various types of voiding dysfunctions were compared to twenty-five age and parity-matched control women in order to determine patient preferences of the Compu-Void when compared to the standard written voiding diary, compliance with each method, and amount and quality of information obtained with each method. Over 90% of subjects and over 70% of control group patients preferred the Compu-Void over the written diary (P Compu-Void exceeded that obtained with the written method.

  6. The life and death of cosmic voids

    CERN Document Server

    Sutter, P M; Falck, Bridget; Onions, Julian; Hamaus, Nico; Knebe, Alexander; Srisawat, Chaichalit; Schneider, Aurel

    2014-01-01

    We investigate the formation, growth, merger history, movement, and destruction of cosmic voids detected via the watershed transform in a cosmological N-body dark matter {\\Lambda}CDM simulation. By adapting a method used to construct halo merger trees, we are able to trace individual voids back to their initial appearance and record the merging and evolution of their progenitors at high redshift. For the scales of void sizes captured in our simulation, we find that the void formation rate peaks at scale factor 0.3, which coincides with a growth in the void hierarchy and the emergence of dark energy. Voids of all sizes appear at all scale factors, though the median initial void size decreases with time. When voids become detectable they have nearly their present-day volumes. Almost all voids have relatively stable growth rates and suffer only infrequent minor mergers. Dissolution of a void via merging is very rare. Instead, most voids maintain their distinct identity as annexed subvoids of a larger parent. The...

  7. The Development of Voiding

    DEFF Research Database (Denmark)

    Olsen, Lars Henning

    2011-01-01

    The thesis addresses some new aspeccts in the development of voiding function from midgestation into early childhood.......The thesis addresses some new aspeccts in the development of voiding function from midgestation into early childhood....

  8. The Void Galaxy Survey

    CERN Document Server

    van de Weygaert, R; Platen, E; Beygu, B; van Gorkom, J H; van der Hulst, J M; Aragon-Calvo, M A; Peebles, P J E; Jarrett, T; Rhee, G; Kovac, K; Yip, C -W

    2011-01-01

    The Void Galaxy Survey (VGS) is a multi-wavelength program to study $\\sim$60 void galaxies. Each has been selected from the deepest interior regions of identified voids in the SDSS redshift survey on the basis of a unique geometric technique, with no a prior selection of intrinsic properties of the void galaxies. The project intends to study in detail the gas content, star formation history and stellar content, as well as kinematics and dynamics of void galaxies and their companions in a broad sample of void environments. It involves the HI imaging of the gas distribution in each of the VGS galaxies. Amongst its most tantalizing findings is the possible evidence for cold gas accretion in some of the most interesting objects, amongst which are a polar ring galaxy and a filamentary configuration of void galaxies. Here we shortly describe the scope of the VGS and the results of the full analysis of the pilot sample of 15 void galaxies.

  9. Supplemental topics on voids

    Energy Technology Data Exchange (ETDEWEB)

    Rood, H.J.

    1988-09-01

    Several topics concerning voids are presented, supplementing the report of Rood (1988). The discovery of the Coma supercluster and void and the recognition of the cosmological significance of superclusters and voids are reviewed. Galaxy redshift surveys and redshift surveys for the Abell clusters and very distant objects are discussed. Solar system and extragalactic dynamics are examined. Also, topics for future observational research on voids are recommended. 50 references.

  10. Cosmology with void-galaxy correlations.

    Science.gov (United States)

    Hamaus, Nico; Wandelt, Benjamin D; Sutter, P M; Lavaux, Guilhem; Warren, Michael S

    2014-01-31

    Galaxy bias, the unknown relationship between the clustering of galaxies and the underlying dark matter density field is a major hurdle for cosmological inference from large-scale structure. While traditional analyses focus on the absolute clustering amplitude of high-density regions mapped out by galaxy surveys, we propose a relative measurement that compares those to the underdense regions, cosmic voids. On the basis of realistic mock catalogs we demonstrate that cross correlating galaxies and voids opens up the possibility to calibrate galaxy bias and to define a static ruler thanks to the observable geometric nature of voids. We illustrate how the clustering of voids is related to mass compensation and show that volume-exclusion significantly reduces the degree of stochasticity in their spatial distribution. Extracting the spherically averaged distribution of galaxies inside voids from their cross correlations reveals a remarkable concordance with the mass-density profile of voids.

  11. The dark matter of galaxy voids

    CERN Document Server

    Sutter, P M; Wandelt, Benjamin D; Weinberg, David H; Warren, Michael S

    2013-01-01

    How do observed voids relate to the underlying dark matter distribution? To examine the spatial distribution of dark matter contained within voids identified in galaxy surveys, we apply Halo Occupation Distribution models representing sparsely and densely sampled galaxy surveys to a high-resolution N-body simulation. We compare these galaxy voids to voids found in the halo distribution, low-resolution dark matter, and high-resolution dark matter. We find that voids at all scales in densely sampled surveys - and medium- to large-scale voids in sparse surveys - trace the same underdensities as dark matter, but they are larger in radius by ~20%, they have somewhat shallower density profiles, and they have centers offset by ~0.4Rv rms. However, in void-to-void comparison we find that shape estimators are less robust to sampling, and the largest voids in sparsely sampled surveys suffer fragmentation at their edges. We find that voids in galaxy surveys always correspond to underdensities in the dark matter, though ...

  12. The dark matter of galaxy voids

    Science.gov (United States)

    Sutter, P. M.; Lavaux, Guilhem; Wandelt, Benjamin D.; Weinberg, David H.; Warren, Michael S.

    2014-03-01

    How do observed voids relate to the underlying dark matter distribution? To examine the spatial distribution of dark matter contained within voids identified in galaxy surveys, we apply Halo Occupation Distribution models representing sparsely and densely sampled galaxy surveys to a high-resolution N-body simulation. We compare these galaxy voids to voids found in the halo distribution, low-resolution dark matter and high-resolution dark matter. We find that voids at all scales in densely sampled surveys - and medium- to large-scale voids in sparse surveys - trace the same underdensities as dark matter, but they are larger in radius by ˜20 per cent, they have somewhat shallower density profiles and they have centres offset by ˜ 0.4Rv rms. However, in void-to-void comparison we find that shape estimators are less robust to sampling, and the largest voids in sparsely sampled surveys suffer fragmentation at their edges. We find that voids in galaxy surveys always correspond to underdensities in the dark matter, though the centres may be offset. When this offset is taken into account, we recover almost identical radial density profiles between galaxies and dark matter. All mock catalogues used in this work are available at http://www.cosmicvoids.net.

  13. Suicidal behavior and aggression-related disorders.

    Science.gov (United States)

    McCloskey, Michael S; Ammerman, Brooke A

    2017-08-09

    Studies of suicidal behavior among those with aggression-related disorders (i.e. intermittent explosive disorder, borderline personality disorder, antisocial personality disorder, and conduct disorder) were examined. The presence of an aggressive disorder generally increased the risk of suicide attempts and mortality, with this effect (when examined) usually existing independent of other psychopathology. However, this may not be the case for antisocial personality disorder. Furthermore, with the exception of intermittent explosive disorder, the extant research suggests severity of aggression was associated with suicide attempt risk in aggression-related disorders. Future research is needed to better understand what mechanisms may influence the suicide-aggression relationship. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Suicide in Obsessive Compulsive and Related Disorders

    Directory of Open Access Journals (Sweden)

    Gonca Karakus

    2015-09-01

    Full Text Available Suicide is a complex term. Suicide attempts are common in women, but completed suicide rates are higher in men. Several demographic factors, stressful life events, previous suicide attempts, childhood abuse, physical or psychiatric disorders are risk factors for suicide. Suicide rates in a variety of mental disorders is more than the normal population. Data on rates and risk factors of suicide in patients with obsessive-compulsive disorder and related disorders are limited. Present data are often associated with patients with obsessive compulsive disorder and body dysmorphic disorder. Lifetime suicidal ideation rates in patients with obsessive compulsive disorder is within a range of 36-63%. Any comorbid psychiatric diagnosis is an important risk factor for suicide in this disorder. This article aims to review the relationship between suicide and obsessive compulsive and related disorders [Archives Medical Review Journal 2015; 24(3.000: 402-413

  15. Voiding dysfunction in children aged five to 15 years

    Directory of Open Access Journals (Sweden)

    Karaklajić Dragana

    2004-01-01

    Full Text Available Voiding dysfunction in children was analyzed in 91 patients in a period from January 1st to October 1st 1998. Most of the patients had functional voiding disorder (92.31%, and only 7.69% manifested monosymptomatic night enuresis. The number of girls was bigger in the group of patients with voiding dysfunction while the boys were predominant in the group with mono-symptomatic nocturnal enuresis. More than a half of children with functional voiding disorder had repeated urinal infections (58.23%, incontinence (93.49%, need for urgent voiding (68.13%, and vesicoureteral reflux (47.61%. The most common type of voiding dysfunction was urge syndrome/urge incontinence. The incidence of dysfunctional voiding disorder was more often in children with scaring changes of kidney which were diagnosed by static scintigraphy.

  16. Obsessive-compulsive disorder and related disorders: a comprehensive survey

    Directory of Open Access Journals (Sweden)

    Solano Paola

    2009-05-01

    Full Text Available Abstract Our aim was to present a comprehensive, updated survey on obsessive-compulsive disorder (OCD and obsessive-compulsive related disorders (OCRDs and their clinical management via literature review, critical analysis and synthesis. Information on OCD and OCRD current nosography, clinical phenomenology and etiology, may lead to a better comprehension of their management. Clinicians should become familiar with the broad spectrum of OCD disorders, since it is a pivotal issue in current clinical psychiatry.

  17. Suicide in Obsessive Compulsive and Related Disorders

    OpenAIRE

    Gonca Karakus; Lut Tamam

    2015-01-01

    Suicide is a complex term. Suicide attempts are common in women, but completed suicide rates are higher in men. Several demographic factors, stressful life events, previous suicide attempts, childhood abuse, physical or psychiatric disorders are risk factors for suicide. Suicide rates in a variety of mental disorders is more than the normal population. Data on rates and risk factors of suicide in patients with obsessive-compulsive disorder and related disorders are limited. Present data are o...

  18. Voids in cosmological simulations over cosmic time

    Science.gov (United States)

    Wojtak, Radosław; Powell, Devon; Abel, Tom

    2016-06-01

    We study evolution of voids in cosmological simulations using a new method for tracing voids over cosmic time. The method is based on tracking watershed basins (contiguous regions around density minima) of well-developed voids at low redshift, on a regular grid of density field. It enables us to construct a robust and continuous mapping between voids at different redshifts, from initial conditions to the present time. We discuss how the new approach eliminates strong spurious effects of numerical origin when voids' evolution is traced by matching voids between successive snapshots (by analogy to halo merger trees). We apply the new method to a cosmological simulation of a standard Λ-cold-dark-matter cosmological model and study evolution of basic properties of typical voids (with effective radii 6 h-1 Mpc < Rv < 20 h-1 Mpc at redshift z = 0) such as volumes, shapes, matter density distributions and relative alignments. The final voids at low redshifts appear to retain a significant part of the configuration acquired in initial conditions. Shapes of voids evolve in a collective way which barely modifies the overall distribution of the axial ratios. The evolution appears to have a weak impact on mutual alignments of voids implying that the present state is in large part set up by the primordial density field. We present evolution of dark matter density profiles computed on isodensity surfaces which comply with the actual shapes of voids. Unlike spherical density profiles, this approach enables us to demonstrate development of theoretically predicted bucket-like shape of the final density profiles indicating a wide flat core and a sharp transition to high-density void walls.

  19. The sparkling Universe: a scenario for cosmic void motions

    Science.gov (United States)

    Ceccarelli, Laura; Ruiz, Andrés N.; Lares, Marcelo; Paz, Dante J.; Maldonado, Victoria E.; Luparello, Heliana E.; Garcia Lambas, Diego

    2016-10-01

    Cosmic voids are prominent features of the Universe, encoding relevant information of the growth and evolution of structure through their dynamics. Here, we perform a statistical study of the global motion of cosmic voids using both a numerical simulation and observational data. Their relation to large-scale mass flows and the physical effects that drive those motions. We analyse the bulk motions of voids, finding void mean bulk velocities in the range 300-400 km s-1, depending on void size and the large-scale environment. Statistically, small voids move faster, and voids in relatively higher density environments have higher bulk velocities. Also, we find large-scale overdensities (underdensities) along (opposite to) the void motion direction, suggesting that void motions respond to a pull-push mechanism. Our analysis suggests that their relative motions are generated by large-scale density fluctuations. In agreement with linear theory, voids embedded in low (high) density regions mutually recede (attract) each other, providing the general mechanism to understand the bimodal behaviour of void motions. We have also inferred void motions in the Sloan Digital Sky Survey using linear theory, finding that their estimated motions are in qualitatively agreement with the results of the simulation. Our results suggest a scenario of galaxies and galaxy systems flowing away from void centres with the additional, and more relevant, contribution of the void bulk motion to the total velocity.

  20. [Sleep disorder and lifestyle-related disease].

    Science.gov (United States)

    Shibata, Rei; Murohara, Toyoaki

    2015-06-01

    Sleep disorder is associated with the lifestyle-related diseases including obesity, insulin resistance and atherosclerosis. Adipose tissue functions as an endocrine organ by producing bioactive secretory proteins, also known as adipokines, that can directly act on nearby or remote organs. Recently, the associations between these adipokines and sleep disorders such as obstructive sleep apnea have been reported. In this review, we focus on the relationship between sleep disorder and lifestyle-related diseases.

  1. Illicit substance-related disorders

    NARCIS (Netherlands)

    Vedel, E.; Emmelkamp, P.M.G.; Sturmey, P.; Hersen, M.

    2012-01-01

    This chapter focuses on evidence-based treatment for illicit drug use disorders. The treatments addressed are motivational interviewing, treatments based on cognitive behavioral principals such as cue exposure, coping skills training and contingency management, and 12-step orientated treatment progr

  2. Voiding dysfunction - A review

    Directory of Open Access Journals (Sweden)

    Sripathi V

    2005-01-01

    Full Text Available In a child who is toilet trained the sudden onset of daytime wetting with frequency or urgency is alarming to the parents. Initially this subject was subdivided into a number of descriptive clinical conditions which led to a lot of confusion in recognition and management. Subsequently, the term elimination dysfunction was coined by Stephen Koff to emphasise the association between recurrent urinary infection, wetting, constipation and bladder overactivity. From a urodynamic point of view, in voiding dysfunction, there is either detrusor overactivity during bladder filling or dyssynergic action between the detrusor and the external sphincter during voiding. Identifying a given condition as a ′filling phase dysfunction′ or ′voiding phase dysfunction′ helps to provide appropriate therapy. Objective clinical criteria should be used to define voiding dysfunction. These include bladder wall thickening, large capacity bladder and infrequent voiding, bladder trabeculation and spinning top deformity of the urethra and a clinically demonstrated Vincent′s curtsy. The recognition and treatment of constipation is central to the adequate treatment of voiding dysfunction. Transcutaneous electric nerve stimuation for the treatment of detrusor overactivity, biofeedback with uroflow EMG to correct dyssynergic voiding, and behavioral therapy all serve to correct voiding dysfunction in its early stages. In established neurogenic bladder disease the use of Botulinum Toxin A injections into the detrusor or the external sphincter may help in restoring continence especially in those refractory to drug therapy. However in those children in whom the upper tracts are threatened, augmentation of the bladder may still be needed.

  3. Modeling cosmic void statistics

    Science.gov (United States)

    Hamaus, Nico; Sutter, P. M.; Wandelt, Benjamin D.

    2016-10-01

    Understanding the internal structure and spatial distribution of cosmic voids is crucial when considering them as probes of cosmology. We present recent advances in modeling void density- and velocity-profiles in real space, as well as void two-point statistics in redshift space, by examining voids identified via the watershed transform in state-of-the-art ΛCDM n-body simulations and mock galaxy catalogs. The simple and universal characteristics that emerge from these statistics indicate the self-similarity of large-scale structure and suggest cosmic voids to be among the most pristine objects to consider for future studies on the nature of dark energy, dark matter and modified gravity.

  4. Draining the Local Void

    CERN Document Server

    Rizzi, Luca; Shaya, Edward J; Kourkchi, Ehsan; Karachentsev, Igor D

    2016-01-01

    Two galaxies that lie deep within the Local Void provide a test of the expectation that voids expand. The modest (M_B~-14) HI bearing dwarf galaxies ALFAZOAJ1952+1428 and KK246 have been imaged with Hubble Space Telescope in order to study the stellar populations and determine distances from the luminosities of stars at the tip of the red giant branch. The mixed age systems have respective distances of 8.39 Mpc and 6.95 Mpc and inferred line-of-sight peculiar velocities of -114 km/s and -66 km/s toward us and away from the void center. These motions compound on the Milky Way motion of ~230 km/s away from the void. The orbits of the two galaxies are reasonably constrained by a numerical action model encompassing an extensive region that embraces the Local Void. It is unambiguously confirmed that these two void galaxies are moving away from the void center at several hundred km/s.

  5. Alexia and related reading disorders.

    Science.gov (United States)

    Bub, Daniel

    2003-05-01

    Peripheral dyslexias are the result of impairment to processes that convert letters on the page into an abstract orthographic representation. Many aspects of these disorders are difficult to understand in depth. Invariably, there is evidence that some type of word-level perception occurs rapidly in many patients with LBL reading or neglect dyslexia, yet apparently contradictory evidence indicates that part of the word has been misperceived or that the letters must be analyzed laboriously for conscious identification to occur. Current theories attempt to synthesize these different aspects of the patients' performance, but their development is at an early stage. Questions remain also about the domain specificity of the perceptual impairment in LBL reading and about the nature of spatial attention and spatial frames in neglect dyslexia and other forms of attentional disorder. Current understanding of central dyslexias has perhaps advanced further. Well-developed computational models exist of these dyslexias, as do plausible experimental techniques for revealing the activity of semantic and non-semantic routes in normal readers. Nevertheless, the difficult issue of domain specificity arises again with respect to some of the mechanisms invoked, and in this regard, central and peripheral dyslexias continue to pose the same challenge.

  6. Dark matter in voids

    Science.gov (United States)

    Fong, Richard; Doroshkevich, Andrei G.; Turchaninov, Victor I.

    1995-07-01

    The theory of the formation of large-scale structure in the universe through the action of gravitational instability imply the existence of substantial amounts of baryonic dark matter, of the order of 50% of the total baryon content in the universe, in the ``voids'' or under-dense regions seen in the large-scale distribution of galaxies. We discuss also the large-scale structure of dark matter expected in voids and the present and future possibilities for the observation of this baryonic dark matter in ``voids.''

  7. Dark matter in voids

    Energy Technology Data Exchange (ETDEWEB)

    Fong, R. [Department of Physics, University of Durham, Durham, DH1 3LE (United Kingdom); Doroshkevich, A.G. [Keldysh Institute of Applied Mathematics, 125047 Moscow (Russian Federation)]|[Teoretical Astrophysics Centrum, Blegsdamsvej 17, Copenhagen DK 2100 (Denmark); Turchaninov, V.I. [Keldysh Institute of Applied Mathematics, 125047 Moscow (Russian Federation)

    1995-07-01

    The theory of the formation of large-scale structure in the universe through the action of gravitational instability imply the existence of substantial amounts of baryonic dark matter, of the order of 50% of the total baryon content in the universe, in the ``voids`` or under-dense regions seen in the large-scale distribution of galaxies. We discuss also the large-scale structure of dark matter expected in voids and the present and future possibilities for the observation of this baryonic dark matter in ``voids.`` {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  8. Voids in cosmological simulations over cosmic time

    CERN Document Server

    Wojtak, Radosław; Abel, Tom

    2016-01-01

    We study evolution of voids in cosmological simulations using a new method for tracing voids over cosmic time. The method is based on tracking watershed basins (contiguous regions around density minima) of well developed voids at low redshift, on a regular grid of density field. It enables us to construct a robust and continuous mapping between voids at different redshifts, from initial conditions to the present time. We discuss how the new approach eliminates strong spurious effects of numerical origin when voids evolution is traced by matching voids between successive snapshots (by analogy to halo merger trees). We apply the new method to a cosmological simulation of a standard LambdaCDM cosmological model and study evolution of basic properties of typical voids (with effective radii between 6Mpc/h and 20Mpc/h at redshift z=0) such as volumes, shapes, matter density distributions and relative alignments. The final voids at low redshifts appear to retain a significant part of the configuration acquired in in...

  9. Bipolar and related disorders and depressive disorders in DSM-5

    Directory of Open Access Journals (Sweden)

    Łojko,Dorota

    2014-04-01

    Full Text Available In 2013, a version of the Diagnostic and Statistical Manual of Mental Disorders (DSM, having number 5, was published. The DSM is a textbook which aims to present diagnostic criteria for each psychiatric disorder recognized by the U.S. healthcare system. The DSM-5 comprises the most updated diagnostic criteria of psychiatric disorders as well as their description, and provides a common language for clinicians to communicate about the patients. Diagnostic criteria of the DSM-5 have been popular all over the world, including countries where the ICD-10 classification is obligatory, and are widely used for clinical and neurobiological research in psychiatry. In this article, two chapters of the DSM-5 pertained to mood (affective disorders are presented, such as “Bipolar and related disorders” and “Depressive disorders” replacing the chapter titled “Mood disorders” in the previous version of DSM-IV. The aim of this article is to discuss a structure of new classification, to point out differences compared with previous version (DSM-IV. New diagnostic categories, such as e.g. disruptive mood dysregulation disorder or premenstrual dysphoric disorder were depicted as well as some elements of dimensional approach to mood disorders were presented.

  10. Genetics Home Reference: MYH9-related disorder

    Science.gov (United States)

    ... They Important? Merck Manual Consumer Version: Glomerulonephritis Merck Manual Consumer Version: Thrombocytopenia Orphanet: MYH9-related disease Patient Support and Advocacy Resources (3 links) National Kidney Foundation National Organization for Rare Disorders (NORD): May Hegglin Anomaly University ...

  11. [AWMF-guideline: disorders related to cannabis].

    Science.gov (United States)

    Bonnet, U; Harries-Hedder, K; Leweke, F M; Schneider, U; Tossmann, P

    2004-06-01

    Actually, guidelines for treatment of substance-related disorders were written under the overall control of the DG-Sucht e. V. and the DGPPN e. V. This appears within the framework of the Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaft (AWMF). The leading objective of these guidelines is the description of the current scientifically proven and evidence-based medicine in addiction to derive recommendations to therapy. In this context, the guideline for treatment of cannabis-related disorders is introduced.

  12. Modelling Void Abundance in Modified Gravity

    CERN Document Server

    Voivodic, Rodrigo; Llinares, Claudio; Mota, David F

    2016-01-01

    We use a spherical model and an extended excursion set formalism with drifting diffusive barriers to predict the abundance of cosmic voids in the context of general relativity as well as f(R) and symmetron models of modified gravity. We detect spherical voids from a suite of N-body simulations of these gravity theories and compare the measured void abundance to theory predictions. We find that our model correctly describes the abundance of both dark matter and galaxy voids, providing a better fit than previous proposals in the literature based on static barriers. We use the simulation abundance results to fit for the abundance model free parameters as a function of modified gravity parameters, and show that counts of dark matter voids can provide interesting constraints on modified gravity. For galaxy voids, more closely related to optical observations, we find that constraining modified gravity from void abundance alone may be significantly more challenging. In the context of current and upcoming galaxy surv...

  13. Work-related lung disorders

    Energy Technology Data Exchange (ETDEWEB)

    Cotes, J.E.; Steel, J.

    1987-01-01

    This book covers the following topics: the protection of health at work; environmental monitoring; providing clean air; respiratory defence mechanisms; screening and examination procedures; occupational respiratory surveys; abnormal conditions of temperature and barometric pressure; silicosis; pneumoconioses of coal workers and related occupations; asbestos and other mineral fibres; beryllium disease; occupational lung cancer; other dusts gases and vapours; byssinosis; extrinsic allergic alveolitis; occupational asthma; chronic bronchitis and emphysema; roles of smoking, occupation and air pollution; exercise tests and respiratory disablement; and management of respiratory impairment.

  14. Voids' System in the Woven Composite Structure

    Institute of Scientific and Technical Information of China (English)

    Pavla VOZKOVA

    2006-01-01

    Composites are common material constructions for high-tech use now. Mechanical properties of woven reinforced composites are influenced by voids inside the structure.Voids could be classified to the two sections. Long and thin cracks are more dangerous than pores. It is important to find relations between preparation and place of occurrence of voids. This paper classifies defects according to rise mechanism, point of occurrence, orientation, size and affect to the properties. Image analysis was used for observing samples. Future work would be oriented not only to observing real samples, but also to calculate mechanical properties from real and ideal structures in 3D woven reinforced composites.

  15. The Beckoning Void in Moravagine

    Directory of Open Access Journals (Sweden)

    Stephen K. Bellstrom

    1979-01-01

    Full Text Available The Chapter «Mascha,» lying at the heart of Cendrars's Moravagine , contains within it a variety of images and themes suggestive of emptiness. The philosophy of nihilism is exemplified in the motivations and actions of the group of terrorists seeking to plunge Russia into revolutionary chaos. Mascha's anatomical orifice, symbolizing both a biological and a psychological fault, and the abortion of her child, paralleled by the abortion of the revolutionary ideal among her comrades, are also emblematic of the chapter's central void. Moreover, Cendrars builds the theme of hollowness by describing Moravagine with images of omission, such as «empan» (space or span, «absent,» and «étranger.» Moravagine's presence, in fact, characteristically causes an undercurrent of doubt and uncertainty about the nature of reality to become overt. It is this parodoxical presence which seems to cause the narrator (and consequently the narrative to «lose» a day at the most critical moment of the story. By plunging the reader into the narrator's lapsus memoriae , Cendrars aims at creating a feeling of the kind of mental and cosmic disorder for which Moravagine is the strategist and apologist. This technique of insufficiency is an active technique, even though it relies on the passive idea of removing explanation and connecting details. The reader is invited, or lured, into the central void of the novel and, faced with unresolvable dilemmas, becomes involved in the same disorder that was initially produced.

  16. Void Coalescence Processes Quantified Through Atomistic and Multiscale Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E; Seppala, E T; Dupuy, L M; Belak, J

    2007-01-12

    Simulation of ductile fracture at the atomic scale reveals many aspects of the fracture process including specific mechanisms associated with void nucleation and growth as a precursor to fracture and the plastic deformation of the material surrounding the voids and cracks. Recently we have studied void coalescence in ductile metals using large-scale atomistic and continuum simulations. Here we review that work and present some related investigations. The atomistic simulations involve three-dimensional strain-controlled multi-million atom molecular dynamics simulations of copper. The correlated growth of two voids during the coalescence process leading to fracture is investigated, both in terms of its onset and the ensuing dynamical interactions. Void interactions are quantified through the rate of reduction of the distance between the voids, through the correlated directional growth of the voids, and through correlated shape evolution of the voids. The critical inter-void ligament distance marking the onset of coalescence is shown to be approximately one void radius based on the quantification measurements used, independent of the initial separation distance between the voids and the strain-rate of the expansion of the system. No pronounced shear flow is found in the coalescence process. We also discuss a technique for optimizing the calculation of fine-scale information on the fly for use in a coarse-scale simulation, and discuss the specific case of a fine-scale model that calculates void growth explicitly feeding into a coarse-scale mechanics model to study damage localization.

  17. Nonlocal plasticity effects on interaction of different size voids

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Niordson, Christian Frithiof

    2004-01-01

    A nonlocal elastic-plastic material model is used to show that the rate of void growth is significantly reduced when the voids are small enough to be comparable with a characteristic material length. For a very small void in the material between much larger voids the competition between...... an increased growth rate due to the stress concentrations around the larger voids and a reduced growth rate due to the nonlocal effects is studied. The analyses are based on an axisymmetric unit cell model with special boundary conditions, which allow for a relatively simple investigation of a full three...

  18. Insomnia and sleep-related breathing disorders.

    Science.gov (United States)

    Wickwire, Emerson M; Collop, Nancy A

    2010-06-01

    Insomnia disorder and obstructive sleep apnea are the two most common sleep disorders among adults. Historically, these conditions have been conceptualized as orthogonal, or insomnia has been considered a symptom of sleep apnea. Insomnia researchers have sought to exclude participants at risk for sleep-related breathing disorders (SRBD), and vice versa. In recent years, however, there has been a growing recognition of co-occurring insomnia disorder and SRBD and interest in the prevalence, consequences, and treatment of the two conditions when they co-occur. Although plagued by inconsistent diagnostic criteria and operational definitions, evidence from clinical and research samples consistently suggests high rates of comorbidity between the two disorders. More important, insomnia disorder and SRBD have additive negative effects. To date, only a few studies have explored the combined or sequential treatment of the conditions. Results support the importance of an integrated, interdisciplinary approach to sleep medicine. This article reviews the empirical literature to date and provides clinical recommendations as well as suggestions for future research.

  19. Work-related musculoskeletal disorders : prevention report

    NARCIS (Netherlands)

    Podniece, Z.; Heuvel, S. van den; Blatter, B.

    2008-01-01

    Work-related musculoskeletal disorders (MSDs) can interfere with activities at work and can lead to reduced productivity, sickness absence and chronic occupational disability. The aim of this report is to systematic evaluate the effectiveness of interventions at the workplace since 2002 and to

  20. Void shape effects and voids starting from cracked inclusion

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2011-01-01

    Numerical, axisymmetric cell model analyses are used to study the growth of voids in ductile metals, until the mechanism of coalescence with neighbouring voids sets in. A special feature of the present analyses is that extremely small values of the initial void volume fraction are considered, dow...

  1. Void Coalescence Processes Quantified through Atomistic and Multiscale Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E; Seppala, E T; Dupuy, L M; Belak, J

    2005-12-31

    Simulation of ductile fracture at the atomic scale reveals many aspects of the fracture process including specific mechanisms associated with void nucleation and growth as a precursor to fracture and the plastic deformation of the material surrounding the voids and cracks. Recently we have studied void coalescence in ductile metals using large-scale atomistic and continuum simulations. Here we review that work and present some related investigations. The atomistic simulations involve three-dimensional strain-controlled multi-million atom molecular dynamics simulations of copper. The correlated growth of two voids during the coalescence process leading to fracture is investigated, both in terms of its onset and the ensuing dynamical interactions. Void interactions are quantified through the rate of reduction of the distance between the voids, through the correlated directional growth of the voids, and through correlated shape evolution of the voids. The critical inter-void ligament distance marking the onset of coalescence is shown to be approximately one void radius based on the quantification measurements used, independent of the initial separation distance between the voids and the strain-rate of the expansion of the system. No pronounced shear flow is found in the coalescence process.

  2. Size-effects at a crack-tip interacting with a number of voids

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Niordson, Christian Frithiof

    2008-01-01

    of the characteristic material length relative to the initial void radius. For a case showing the multiple void mechanism, it is found that the effect of the material length can change the behaviour towards the void by void mechanism. A material model with three characteristic length scales is compared with a one...

  3. Neurogenic voiding dysfunction.

    Science.gov (United States)

    Georgopoulos, Petros; Apostolidis, Apostolos

    2017-05-01

    This review aims to analyze and discuss all recently published articles associated with neurogenic voiding discussion providing readers with the most updated knowledge and trigger for further research. They include the proposal of a novel classification system for the pathophysiology of neurogenic lower urinary tract dysfunction (NLUTD) which combines neurological defect in a distinct anatomic location, and data on bowel dysfunction, autonomic dysreflexia and urine biomarkers; review of patient-reported outcome measures in NLUTD; review of the criteria for the diagnosis of clinically significant urinary infections; novel research findings on the pathophysiology of NLUTD; and review of data on minimally and more invasive treatments. Despite the extended evidence base on NLUTD, there is a paucity of high-quality new research concerning voiding dysfunction as opposed to storage problems. The update aims to inform clinicians about new developments in clinical practice, as well as ignite discussion for further clinical and basic research in the aforementioned areas of NLUTD.

  4. A computerized voiding diary.

    Science.gov (United States)

    Rabin, J M; McNett, J; Badlani, G H

    1996-11-01

    To examine a group of subject and control patient's preferences and compliance with regard to the Compu-Void (CV) electronic voiding diary as compared to the written diary (WD) and to compare the two methods with respect to the type of information obtained and whether the order of use of each method influenced results in the subject group. Thirty-six women between the ages of 20 and 84 with bladder symptoms were compared to a group of 36 age-matched women. In 100% of subjects and 95% of control patients, CV entries exceeded the number made with the WD in voiding events and, in subjects, in incontinence episodes recorded (P < .005 and P < .005, respectively). Over 98% of subjects and over 80% of controls preferred the CV (P < .0005). The order of use of each method in subjects made no significant difference with regard to the volume of information obtained (P < .407), number of leakage events recorded (P < .494) or fluid intake patterns (P < .410). Patients' compliance with each method was not affected by the order of use. Our results suggest an increased volume of data and greater patient compliance in reporting bladder symptoms and events using the CV and that the order of use is not important.

  5. The view from the boundary: a new void stacking method

    CERN Document Server

    Cautun, Marius; Frenk, Carlos S

    2015-01-01

    We introduce a new method for stacking voids and deriving their profile that greatly increases the potential of voids as a tool for precision cosmology. Given that voids are highly non-spherical and have most of their mass at their edge, voids are better described relative to their boundary rather than relative to their centre, as in the conventional spherical stacking approach. The boundary profile is obtained by computing the distance of each volume element from the void boundary. Voids can then be stacked and their profiles computed as a function of this boundary distance. This approach enhances the weak lensing signal of voids, both shear and convergence, by a factor of two when compared to the spherical stacking method. It also results in steeper void density profiles that are characterised by a very slow rise inside the void and a pronounced density ridge at the void boundary, in qualitative agreement with theoretical models of expanding spherical underdensities. The resulting boundary density profile i...

  6. The sparkling Universe: the coherent motions of cosmic voids

    CERN Document Server

    Lambas, Diego G; Ceccarelli, Laura; Ruiz, Andrés N; Paz, Dante J; Maldonado, Victoria E; Luparello, Heliana E

    2015-01-01

    We compute the bulk motions of cosmic voids, using a $\\Lambda$CDM numerical simulation considering the mean velocities of the dark matter inside the void itself and that of the haloes in the surrounding shell. We find coincident values of these two measures in the range $\\sim$ 300-400 km/s, not far from the expected mean peculiar velocities of groups and galaxy clusters. When analysing the distribution of the pairwise relative velocities of voids, we find a remarkable bimodal behaviour consistent with an excess of both systematically approaching and receding voids. We determine that the origin of this bimodality resides in the void large scale environment, since once voids are classified into void-in-void (R-type) or void-in-cloud (S-type), R-types are found mutually receding away, while S-types approach each other. The magnitude of these systematic relative velocities account for more than 100 km/s, reaching large coherence lengths of up to 200 h$^{-1}$ Mpc . We have used samples of voids from the Sloan Digi...

  7. Epigenetic manifestations in diet-related disorders.

    Science.gov (United States)

    Mariman, E C M

    2008-01-01

    Epigenetic phenomena are changes in phenotype that are due to resetting of gene expression under the influence of the environment or genetic factors without changing the DNA sequence. Usually this resetting occurs at a certain stage in life and remains fixed thereafter. In humans, evidence for epigenetic involvement in diet-related complex traits and disorders is accumulating. The fetal origins theory indicates that nutrition can influence the later life risk for certain common disorders like the metabolic syndrome. In parent-of-origin effects, the risk for a common disorder like type I diabetes depends on the sex of the parent who transmits genetic risk factors. Interestingly, both dietary and genetic factors can exert their epigenetic influence over several generations. Imprinting, i.e. silencing of one copy of an autosomal pair of genes, can be part of the mechanism pointing to the importance of DNA methylation. In addition, chromatin modifications have been shown to be involved in epigenetic manifestations. The intriguing possibility that diet may influence the direction and extent of epigenetic changes opens new ways for prevention or treatment of common disorders. At the same time, maternal nutrition might be used to actively direct fetal development with consequences for later life performance such as cognitive abilities. More knowledge on those novel applications is needed. This will in part come from novel strategies to map the epigenomic regions, allowing the identification of more genes involved in epigenetics and allowing the study of their response to nutrition.

  8. Systemic atherosclerosis and voiding symptom.

    Science.gov (United States)

    Yeniel, A Ozgur; Ergenoglu, A Mete; Meseri, Reci; Ari, Anıl; Sancar, Ceren; Itil, Ismail Mete

    2017-03-01

    To evaluate the effect of atherosclerosis on the storage and voiding symptoms of the bladder in women with overactive bladder (OAB). We retrospectively reviewed the charts of women with OAB who were evaluated between 2013 and 2015 in our urogynecology unit. Charts were assessed for history, examination findings, urinary diary, quality of life (QOL) questionnaires, urodynamic studies (UDSs), and four main risk factors for atherosclerosis: hypertension, diabetes mellitus, smoking, and hyperlipidemia. In a previous study, these were defined as vascular risk factors. Cases were excluded for insufficient data, diabetes mellitus with dysregulated blood glucose, or prolapse greater than 1cm to avoid confusing bladder outlet obstruction. We included 167 eligible cases in this study. We evaluated storage and voiding symptoms such as frequency, nocturia, residual urine volume, and voiding difficulties and UDS findings such as maximum bladder capacity, first desire, strong desire, detrusor overactivity, and bladder contractility index. The vascular risk score was categorized as "no risk" if the woman did not have any of the four risk factors and "at risk" if she had any of the factors. Independent sample t-test and chi-square tests were performed for analyses. Among the participants (n=167), 71.9% had at least one vascular risk factor. Those who were at risk were facing significantly more wet-type OAB (p=0.003) and nocturia (p=0.023). Moreover, mean age (p=0.008) and mean gravidity (p=0.020) were significantly higher in the at-risk group, whereas mean total nocturia QOL questionnaire scores (p=0.029) were significantly lower. Our findings suggest that aging and atherosclerosis may be associated with severe OAB and poorer QOL. Nocturia and related parameters of poor quality can be explained by impaired bladder neck perfusion. Future trials need to assess vascular and molecular changes in women with OAB. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Cytokines and HCV-Related Disorders

    Directory of Open Access Journals (Sweden)

    Poupak Fallahi

    2012-01-01

    However, HCV interferes with cytokines at various levels and escapes immune response by inducing a T-helper (Th2/T cytotoxic 2 cytokine profile. Inability to control infection leads to the recruitment of inflammatory infiltrates into the liver parenchyma by interferon (IFN-gamma-inducible CXC chemokine ligand (CXCL-9, -10, and -11 chemokines, which results in sustained liver damage and eventually in liver cirrhosis. The most important systemic HCV-related extrahepatic diseases—mixed cryoglobulinemia, lymphoproliferative disorders, thyroid autoimmune disorders, and type 2 diabetes—are associated with a complex dysregulation of the cytokine/chemokine network, involving proinflammatory and Th1 chemokines. The therapeutical administration of cytokines such as IFN-alpha may result in viral clearance during persistent infection and reverts this process.

  10. Effects of Voids on Concrete Tensile Fracturing: A Mesoscale Study

    Directory of Open Access Journals (Sweden)

    Lei Xu

    2017-01-01

    Full Text Available A two-dimensional mesoscale modeling framework, which considers concrete as a four-phase material including voids, is developed for studying the effects of voids on concrete tensile fracturing under the plane stress condition. Aggregate is assumed to behave elastically, while a continuum damaged plasticity model is employed to describe the mechanical behaviors of mortar and ITZ. The effects of voids on the fracture mechanism of concrete under uniaxial tension are first detailed, followed by an extensive investigation of the effects of void volume fraction on concrete tensile fracturing. It is found that both the prepeak and postpeak mesoscale cracking in concrete are highly affected by voids, and there is not a straightforward relation between void volume fraction and the postpeak behavior due to the randomness of void distribution. The fracture pattern of concrete specimen with voids is controlled by both the aggregate arrangement and the distribution of voids, and two types of failure modes are identified for concrete specimens under uniaxial tension. It is suggested that voids should be explicitly modeled for the accurate fracturing simulation of concrete on the mesoscale.

  11. Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG

    Energy Technology Data Exchange (ETDEWEB)

    Dewey, Stephen L. (Manorville, NY); Brodie, Jonathan D. (Cos Cob, CT); Ashby, Jr., Charles R. (Miller Place, NY)

    2002-01-01

    The present invention relates to the use of gamma vinyl-GABA (GVG) to treat obsessive-compulsive disorder (OCD) and OCD-related disorders, and to reduce or eliminate behaviors associated with obsessive-compulsive disorder (OCD) and OCD-related disorders.

  12. Into the Void

    Science.gov (United States)

    2006-01-01

    17 May 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a portion of a chain of pits on a lava- and dust-covered plain northwest of Tharsis Tholus -- one of the many volcanic constructs in the Tharsis region of Mars. Pit chains, such as this one, are associated with the collapse of surface materials into subsurface voids formed by faulting and expansion -- or extension -- of the bedrock. Location near: 16.4oN, 92.6oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Winter

  13. [Sleep and autonomic function: sleep related breathing disorders in Parkinson's disease and related disorders].

    Science.gov (United States)

    Suzuki, Keisuke; Miyamoto, Masayuki; Miyamoto, Tomoyuki; Hirata, Koichi

    2014-01-01

    In patients with multiple system atrophy (MSA), sleep related breathing disorders (SRBD), including obstructive and central sleep apnea, vocal cord abductor paralysis and dysrhythmic breathing pattern, are frequently observed. SRBD may have a considerable impact on variation of autonomic nervous activity during sleep. The previous studies correlated upper airway muscle dysfunction related parkinsonism with increased prevalence of SRBD in patients with Parkinson's disease (PD). However, recently, the clinical significance of SRBD and its impact on sleepiness and disease severity have been debated. In this review, we discuss sleep and autonomic function, especially, SRBD in PD and related disorders, including the previous studies from our department.

  14. Voids and the Cosmic Web: cosmic depressions & spatial complexity

    CERN Document Server

    van de Weygaert, Rien

    2016-01-01

    Voids form a prominent aspect of the Megaparsec distribution of galaxies and matter. Not only do they represent a key constituent of the Cosmic Web, they also are one of the cleanest probes and measures of global cosmological parameters. The shape and evolution of voids are highly sensitive to the nature of dark energy, while their substructure and galaxy population provides a direct key to the nature of dark matter. Also, the pristine environment of void interiors is an important testing ground for our understanding of environmental influences on galaxy formation and evolution. In this paper, we review the key aspects of the structure and dynamics of voids, with a particular focus on the hierarchical evolution of the void population. We demonstrate how the rich structural pattern of the Cosmic Web is related to the complex evolution and buildup of voids.

  15. Helicobacter pylori and pregnancy-related disorders

    Science.gov (United States)

    Cardaropoli, Simona; Rolfo, Alessandro; Todros, Tullia

    2014-01-01

    Helicobacter pylori (H. pylori) infection is investigated in gastric diseases even during pregnancy. In particular, this Gram-negative bacterium seems to be associated with hyperemesis gravidarum, a severe form of nausea and vomiting during pregnancy. During the last decade, the relationship among H. pylori and several extra-gastric diseases strongly emerged in literature. The correlation among H. pylori infection and pregnancy-related disorders was mainly focused on iron deficiency anemia, thrombocytopenia, fetal malformations, miscarriage, pre-eclampsia and fetal growth restriction. H. pylori infection may have a role in the pathogenesis of various pregnancy-related disorders through different mechanisms: depletion of micronutrients (iron and vitamin B12) in maternal anemia and fetal neural tube defects; local or systemic induction of pro-inflammatory cytokines release and oxidative stress in gastrointestinal disorders and pre-eclampsia; cross-reaction between specific anti-H. pylori antibodies and antigens localized in placental tissue and endothelial cells (pre-eclampsia, fetal growth restriction, miscarriage). Since H. pylori infection is most likely acquired before pregnancy, it is widely believed that hormonal and immunological changes occurring during pregnancy could activate latent H. pylori with a negative impact not only on maternal health (nutritional deficiency, organ injury, death), but also on the fetus (insufficient growth, malformation, death) and sometime consequences can be observed later in life. Another important issue addressed by investigators was to determine whether it is possible to transmit H. pylori infection from mother to child and whether maternal anti-H. pylori antibodies could prevent infant’s infection. Studies on novel diagnostic and therapeutic methods for H. pylori are no less important, since these are particularly sensitive topics in pregnancy conditions. It could be interesting to study the possible correlation between H

  16. CTF Void Drift Validation Study

    Energy Technology Data Exchange (ETDEWEB)

    Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gosdin, Chris [Pennsylvania State Univ., University Park, PA (United States); Avramova, Maria N. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gergar, Marcus [Pennsylvania State Univ., University Park, PA (United States)

    2015-10-26

    This milestone report is a summary of work performed in support of expansion of the validation and verification (V&V) matrix for the thermal-hydraulic subchannel code, CTF. The focus of this study is on validating the void drift modeling capabilities of CTF and verifying the supporting models that impact the void drift phenomenon. CTF uses a simple turbulent-diffusion approximation to model lateral cross-flow due to turbulent mixing and void drift. The void drift component of the model is based on the Lahey and Moody model. The models are a function of two-phase mass, momentum, and energy distribution in the system; therefore, it is necessary to correctly model the ow distribution in rod bundle geometry as a first step to correctly calculating the void distribution due to void drift.

  17. Bipolar and related disorders and depressive disorders in DSM-5

    OpenAIRE

    Łojko, Dorota; Suwalska, Aleksandra; Rybakowski, Janusz

    2014-01-01

    In 2013, a version of the Diagnostic and Statistical Manual of Mental Disorders (DSM), having number 5, was published. The DSM is a textbook which aims to present diagnostic criteria for each psychiatric disorder recognized by the U.S. healthcare system. The DSM-5 comprises the most updated diagnostic criteria of psychiatric disorders as well as their description, and provides a common language for clinicians to communicate about the patients. Diagnostic criteria of the DSM-5 have been popula...

  18. The sparkling Universe: a scenario for cosmic void motions

    CERN Document Server

    Ceccarelli, Laura; Lares, Marcelo; Paz, Dante J; Maldonado, Victoria E; Luparello, Heliana E; Lambas, Diego Garcia

    2015-01-01

    We perform a statistical study of the global motion of cosmic voids using both a numerical simulation and observational data. We analyse their relation to large--scale mass flows and the physical effects that drive those motions. We analyse the bulk motions of voids, defined by the mean velocity of haloes in the surrounding shells in the numerical simulation, and by galaxies in the Sloan Digital Sky Survey Data Release 7. We find void mean bulk velocities close to 400 km/s, comparable to those of haloes (~ 500-600 km/s), depending on void size and the large--scale environment. Statistically, small voids move faster than large ones, and voids in relatively higher density environments have higher bulk velocities than those placed in large underdense regions. Also, we analyze the mean mass density around voids finding, as expected, large--scale overdensities (underdensities) along (opposite to) the void motion direction, suggesting that void motions respond to a pull--push mechanism. This contrasts with massive ...

  19. Cosmic Voids: structure, dynamics and galaxies

    CERN Document Server

    van de Weygaert, Rien

    2009-01-01

    In this review we discuss several aspects of Cosmic Voids. Voids are a major component of the large scale distribution of matter and galaxies in the Universe. They are of instrumental importance for understanding the emergence of the Cosmic Web. Their relatively simple shape and structure makes them into useful tools for extracting the value of a variety cosmic parameters, possibly including even that of the influence of dark energy. Perhaps most promising and challenging is the issue of the galaxies found within their realm. Not only does the pristine environment of voids provide a promising testing ground for assessing the role of environment on the formation and evolution of galaxies, the dearth of dwarf galaxies may even represent a serious challenge to the standard view of cosmic structure formation.

  20. Sex-Related Differences in GI Disorders.

    Science.gov (United States)

    Prusator, Dawn K; Chang, Lin

    2017-02-24

    Epidemiological studies indicate sex-related differences among functional gastrointestinal disorders (FGIDs) wherein females are more likely to receive a diagnosis than their male counterparts. However, the mechanism by which females exhibit an increased vulnerability for development of these pathophysiologies remains largely unknown, and therapeutic treatments are limited. The current chapter focuses on clinical research outlining our current knowledge of factors that contribute to the female predominance among FGID patients such as the menstrual cycle and sex hormones. In addition, we will discuss progress in preclinical research, including animal models, which serve as valuable tools for the investigation of the development and long term manifestation of symptoms observed within the patient population. Although much progress has been made, additional longitudinal studies in both clinical and preclinical research are necessary to identify more specific mechanisms underlying sex-related differences in FGIDs as well as targets for improved therapeutic approaches.

  1. New Statistical Perspective to The Cosmic Void Distribution

    CERN Document Server

    Pycke, Jean-Renaud

    2016-01-01

    In this study, we obtain the size distribution of voids as a 3-parameter redshift independent log-normal void probability function (VPF) directly from the Cosmic Void Catalog (CVC). Although many statistical models of void distributions are based on the counts in randomly placed cells, the log-normal VPF that we here obtain is independent of the shape of the voids due to the parameter-free void finder of the CVC. We use three void populations drawn from the CVC generated by the Halo Occupation Distribution (HOD) Mocks which are tuned to three mock SDSS samples to investigate the void distribution statistically and the effects of the environments on the size distribution. As a result, it is shown that void size distributions obtained from the HOD Mock samples are satisfied by the 3-parameter log-normal distribution. In addition, we find that there may be a relation between hierarchical formation, skewness and kurtosis of the log-normal distribution for each catalog. We also show that the shape of the 3-paramet...

  2. The Metallicity of Void Dwarf Galaxies

    NARCIS (Netherlands)

    Kreckel, K.; Croxall, K.; Groves, B.; van de Weygaert, R.; Pogge, R. W.

    2015-01-01

    The current ΛCDM cosmological model predicts that galaxy evolution proceeds more slowly in lower density environments, suggesting that voids are a prime location to search for relatively pristine galaxies that are representative of the building blocks of early massive galaxies. To test the assumptio

  3. Bipolar Disorder and Alcoholism: Are They Related?

    Science.gov (United States)

    ... systematic review and meta-analysis of comorbidity rates. European Psychiatry. 2014;29:117. Do EK, et al. Comorbidity ... risk for bipolar disorder and alcohol use disorders. European Psychiatry. 2014;29:282. April 06, 2016 Original article: ...

  4. Experimental and numerical investigation of voids distribution in VPI for ITER correction coil

    Energy Technology Data Exchange (ETDEWEB)

    Li, Juping, E-mail: ljping@ipp.ac.cn; Wu, Jiefeng; Yu, Xiaowu

    2015-06-15

    Highlights: • A sample of correction coil was treated by vacuum pressure impregnation. • The voids in sample were observed by computed tomography. • The voids distributions were simulated in 2-D and 3-D model. • The calculated voids locations had a good agreement with experiment. • The simulation was not accurate in calculating the voids content. - Abstract: The experimental and numerical investigations were conducted to study the voids distribution in VPI (Vacuum Pressure Impregnation) process for correction coil. A sample of correction coil was manufactured by VPI. The voids in sample were observed with computed tomography and the average voids content was tested. The voids content is closely related to infiltration velocity and fluid properties. In former researches, the parameters affecting voids content were combined into a single parameter, namely capillary number. By calculating the capillary numbers in different areas of the sample, the voids distribution could be acquired. The corresponding numerical analyses based on Darcy law were conducted in 2-D and 3-D models. The 2-D case was used to simulate the voids distribution on the section as a simplified model, while the 3-D case demonstrated the spatial distribution of voids. The voids locations were similar in 2-D and 3-D cases, but the voids contents were different. The numerical results were compared with the actual voids distribution in sample. It was found the voids locations were close in numerical and experimental results, but the voids content did not match. The numerical simulations are available for predicting the voids locations in VPI, but not accurate in calculating the voids content.

  5. SURFACE EFFECT ON NANOSIZED VOID GROWTH IN A RIGID-PERFECTLY PLASTIC MATERIAL

    Institute of Scientific and Technical Information of China (English)

    Tong Hui; Yiheng Chen

    2008-01-01

    The influence of the surface effect on the nanosized spherical void growth in a rigid-perfectly plastic material is analyzed and the mechanism of the nanosized void growth with high triaxiality is given. Based on the Rice and Tracey model for a macro void growth, the present model is proposed to account for the nanosized void growth under a uniform remote strain rate field with consideration on the surface effect. It is concluded that the surface effect yields an evident resistant influence on the nanosized void growth. That is, this influence decays as the void radius increases. With high triaxiality, the nanosized void growth is divided into two stages:the initial stage and the mature stage. At the first stage, the void grows slowly and the influence of surface effect is relatively weak, whereas at the second stage, the influene is significant and the void grows drastically.

  6. Genetics Home Reference: FOXP2-related speech and language disorder

    Science.gov (United States)

    ... FOXP2-related speech and language disorder FOXP2-related speech and language disorder Printable PDF Open All Close All Enable Javascript ... Information & Resources MedlinePlus (3 links) Encyclopedia: Apraxia Encyclopedia: Speech Disorders - Children Health Topic: Speech and Language Problems in ...

  7. Transdiagnostic brain responses to disorder-related threat across four psychiatric disorders.

    Science.gov (United States)

    Feldker, K; Heitmann, C Y; Neumeister, P; Tupak, S V; Schrammen, E; Moeck, R; Zwitserlood, P; Bruchmann, M; Straube, T

    2017-03-01

    There is an ongoing debate whether transdiagnostic neural mechanisms are shared by different anxiety-related disorders or whether different disorders show distinct neural correlates. To investigate this issue, studies controlling for design and stimuli across multiple anxiety-related disorders are needed. The present functional magnetic resonance imaging study investigated neural correlates of visual disorder-related threat processing across unmedicated patients suffering from panic disorder (n = 20), social anxiety disorder (n = 20), dental phobia (n = 16) and post-traumatic stress disorder (n = 11) relative to healthy controls (HC; n = 67). Each patient group and the corresponding HC group saw a tailor-made picture set with 50 disorder-related and 50 neutral scenes. Across all patients, increased activation to disorder-related v. neutral scenes was found in subregions of the bilateral amygdala. In addition, activation of the lateral amygdala to disorder-related v. neutral scenes correlated positively with subjective anxiety ratings of scenes across patients. Furthermore, whole-brain analysis revealed increased responses to disorder-related threat across the four disorders in middle, medial and superior frontal regions, (para-)limbic regions, such as the insula and thalamus, as well as in the brainstem and occipital lobe. We found no disorder-specific brain responses. The results suggest that pathologically heightened lateral amygdala activation is linked to experienced anxiety across anxiety disorders and trauma- and stressor-related disorders. Furthermore, the transdiagnostically shared activation network points to a common neural basis of abnormal responses to disorder-related threat stimuli across the four investigated disorders.

  8. Voids and superstructures: correlations and induced large-scale velocity flows

    Science.gov (United States)

    Lares, Marcelo; Luparello, Heliana E.; Maldonado, Victoria; Ruiz, Andrés N.; Paz, Dante J.; Ceccarelli, Laura; Garcia Lambas, Diego

    2017-09-01

    The expanding complex pattern of filaments, walls and voids build the evolving cosmic web with material flowing from underdense on to high density regions. Here, we explore the dynamical behaviour of voids and galaxies in void shells relative to neighbouring overdense superstructures, using the Millenium simulation and the main galaxy catalogue in Sloan Digital Sky Survey data. We define a correlation measure to estimate the tendency of voids to be located at a given distance from a superstructure. We find voids-in-clouds (S-types) preferentially located closer to superstructures than voids-in-voids (R-types) although we obtain that voids within ∼40 h-1 Mpc of superstructures are infalling in a similar fashion independently of void type. Galaxies residing in void shells show infall towards the closest superstructure, along with the void global motion, with a differential velocity component depending on their relative position in the shell with respect to the direction to the superstructure. This effect is produced by void expansion and therefore is stronger for R-types. We also find that galaxies in void shells facing the superstructure flow towards the overdensities faster than galaxies elsewhere at the same relative distance to the superstructure. The results obtained for the simulation are also reproduced for the Sky Survey Data Release data with a linearized velocity field implementation.

  9. PRECISION COSMOGRAPHY WITH STACKED VOIDS

    Energy Technology Data Exchange (ETDEWEB)

    Lavaux, Guilhem [Department of Physics, University of Illinois at Urbana-Champaign, 1002 West Green Street, Urbana, IL 61801 (United States); Wandelt, Benjamin D. [UPMC Univ Paris 06, UMR 7095, Institut d' Astrophysique de Paris, 98 bis, boulevard Arago, 75014 Paris (France)

    2012-08-01

    We present a purely geometrical method for probing the expansion history of the universe from the observation of the shape of stacked voids in spectroscopic redshift surveys. Our method is an Alcock-Paczynski (AP) test based on the average sphericity of voids posited on the local isotropy of the universe. It works by comparing the temporal extent of cosmic voids along the line of sight with their angular, spatial extent. We describe the algorithm that we use to detect and stack voids in redshift shells on the light cone and test it on mock light cones produced from N-body simulations. We establish a robust statistical model for estimating the average stretching of voids in redshift space and quantify the contamination by peculiar velocities. Finally, assuming that the void statistics that we derive from N-body simulations is preserved when considering galaxy surveys, we assess the capability of this approach to constrain dark energy parameters. We report this assessment in terms of the figure of merit (FoM) of the dark energy task force and in particular of the proposed Euclid mission which is particularly suited for this technique since it is a spectroscopic survey. The FoM due to stacked voids from the Euclid wide survey may double that of all other dark energy probes derived from Euclid data alone (combined with Planck priors). In particular, voids seem to outperform baryon acoustic oscillations by an order of magnitude. This result is consistent with simple estimates based on mode counting. The AP test based on stacked voids may be a significant addition to the portfolio of major dark energy probes and its potentialities must be studied in detail.

  10. Neurobiological findings related to Internet use disorders.

    Science.gov (United States)

    Park, Byeongsu; Han, Doug Hyun; Roh, Sungwon

    2016-07-23

    In the last 10 years, numerous neurobiological studies have been conducted on Internet addiction or Internet use disorder. Various neurobiological research methods - such as magnetic resonance imaging; nuclear imaging modalities, including positron emission tomography and single photon emission computed tomography; molecular genetics; and neurophysiologic methods - have made it possible to discover structural or functional impairments in the brains of individuals with Internet use disorder. Specifically, Internet use disorder is associated with structural or functional impairment in the orbitofrontal cortex, dorsolateral prefrontal cortex, anterior cingulate cortex, and posterior cingulate cortex. These regions are associated with the processing of reward, motivation, memory, and cognitive control. Early neurobiological research results in this area indicated that Internet use disorder shares many similarities with substance use disorders, including, to a certain extent, a shared pathophysiology. However, recent studies suggest that differences in biological and psychological markers exist between Internet use disorder and substance use disorders. Further research is required for a better understanding of the pathophysiology of Internet use disorder.

  11. Voids and the Cosmic Web: cosmic depression & spatial complexity

    Science.gov (United States)

    van de Weygaert, Rien

    2016-10-01

    Voids form a prominent aspect of the Megaparsec distribution of galaxies and matter. Not only do theyrepresent a key constituent of the Cosmic Web, they also are one of the cleanest probesand measures of global cosmological parameters. The shape and evolution of voids are highly sensitive tothe nature of dark energy, while their substructure and galaxy population provides a direct key to thenature of dark matter. Also, the pristine environment of void interiors is an important testing groundfor our understanding of environmental influences on galaxy formation and evolution. In this paper, we reviewthe key aspects of the structure and dynamics ofvoids, with a particular focus on the hierarchical evolution of the void population. We demonstratehow the rich structural pattern of the Cosmic Web is related to the complex evolution and buildupof voids.

  12. Psychiatric disorders related to polycystic ovary syndrome.

    Science.gov (United States)

    Krępuła, Katarzyna; Bidzińska-Speichert, Bożena; Lenarcik, Agnieszka; Tworowska-Bardzińska, Urszula

    2012-01-01

    Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The psychiatric disorders accompanying the clinical symptoms and hormonal abnormalities are important, but underestimated, aspects in PCOS. Obesity, hirsutism, acne, menstrual disturbances and infertility play important roles in lowering the quality of life in women with PCOS. Depression and anxiety are more often observed in patients with PCOS than in healthy women. Some authors consider that there is a relationship between valproic acid treatment of bipolar disease and PCOS. There have been reports that in women with PCOS anorexia nervosa, bulimia nervosa and other unspecified eating disorders are found more often than in the general population.

  13. Disorders of mitochondria and related metabolism.

    Science.gov (United States)

    Zeviani, M; Fernandez-Silva, P; Tiranti, V

    1997-04-01

    Mitochondrial disorders are caused by mutations in either nuclear or mitochondrial genes involved in the synthesis of respiratory chain subunits or in their post-translational control. Molecular lesions of mitochondrial DNA are a frequent cause of defective oxidative phosphorylation. Although only one mutation of nuclear-encoded oxidative phosphorylation subunits has so far been reported in humans, numerous biochemically defined disorders are attributed to nuclear gene defects. The pathogenesis of these disorders has been investigated through a combination of different expertises, including keen clinical observation, classical biochemistry and muscle morphology, molecular and cellular biology, linkage analysis and population genetic studies.

  14. Eating Expectancies in Relation to Eating Disorder Recovery

    OpenAIRE

    Fitzsimmons-Craft, Ellen E.; Keatts, Dara A.; Bardone-Cone, Anna M.

    2013-01-01

    This study examined the relation between eating expectancies, assessed via the Eating Expectancy Inventory, and eating disorder recovery. Individuals formerly seen for an eating disorder were categorized as having an active eating disorder (n = 53), as partially recovered (n = 15), or as fully recovered (n = 20). The expectancies of these groups were compared to each other and to 67 non-eating disorder controls. Results revealed that three of the five eating expectancies differed across group...

  15. System Driven by Correlated Gaussian Noises Related with Disorder

    Institute of Scientific and Technical Information of China (English)

    LI Jing-Hui

    2007-01-01

    A system driven by correlated Gaussian noises related with disorder is investigated. The Fokker-Planck equation (FPE) for the system is derived. Using the FPE derived, some systems driven by correlated Gaussian noises related with disorder can be investigated for Brownian motors, nonequilibrium transition, resonant activation,stochastic resonance, and so on. We only give one example: i.e., using the FPE derived, we study the resonant activation for a single motor protein model with correlated noises related to disorder. Since the correlated noise related to disorder usually exists with the friction, for the temperature, and so on, our results have generic physical meanings for physics, chemistry, biology and other sciences.

  16. Elastic–plastic void expansion in near-self-similar shapes

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2011-01-01

    For void growth in an elastic–plastic strain hardening material the preferred shape of the void is calculated, dependent on the macroscopic stress state. Axisymmetric cell model analyses are carried out with a very small initial void size relative to the cell dimensions. Large deformations of the...

  17. Gluten-related disorders: gluten ataxia.

    Science.gov (United States)

    Hadjivassiliou, Marios; Sanders, David D; Aeschlimann, Daniel P

    2015-01-01

    The term gluten-related disorders (GRD) refers to a spectrum of diverse clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals. They include both intestinal and extraintestinal manifestations. Gluten ataxia (GA) is one of the commonest neurological manifestations of GRD. It was originally defined as otherwise idiopathic sporadic ataxia in the presence of circulating antigliadin antibodies of IgA and/or IgG type. Newer more specific serological markers have been identified but are not as yet readily available. GA has a prevalence of 15% amongst all ataxias and 40% of all idiopathic sporadic ataxias. It usually presents with gait and lower limb ataxia. It is of insidious onset with a mean age at onset of 53 years. Up to 40% of patients have evidence of enteropathy on duodenal biopsy. Gastrointestinal symptoms are seldom prominent and are not a reliable indicator for the presence of enteropathy. Furthermore, the presence of enteropathy does not influence the response to a gluten-free diet. Most patients will stabilise or improve with strict adherence to gluten-free diet depending on the duration of the ataxia prior to the treatment. Up to 60% of patients with GA have evidence of cerebellar atrophy on MR imaging, but all patients have spectroscopic abnormalities primarily affecting the vermis. Recent evidence suggests that patients with newly diagnosed coeliac disease presenting to the gastroenterologists have abnormal MR spectroscopy at presentation associated with clinical evidence of subtle cerebellar dysfunction. The advantage of early diagnosis and treatment (mean age 42 years in patients presenting with gastrointestinal symptoms vs. 53 years in patients presenting with ataxia) may protect the first group from the development and/or progression of neurological dysfunction. © 2015 S. Karger AG, Basel.

  18. Scaling of voids and fractality in the galaxy distribution

    CERN Document Server

    Gaite, J; Gaite, Jose; Manrubia, Susanna C.

    2002-01-01

    We study here, from first principles, what properties of voids are to be expected in a fractal point distribution and how the void distribution is related to its morphology. We show this relation in various examples and apply our results to the distribution of galaxies. If the distribution of galaxies forms a fractal set, then this property results in a number of scaling laws to be fulfilled by voids. Consider a fractal set of dimension $D$ and its set of voids. If voids are ordered according to decreasing sizes (largest void has rank R=1, second largest R=2 and so on), then a relation between size $\\Lambda$ and rank of the form $\\Lambda (R) \\propto R^{-z}$ must hold, with $z = d/D$, and where $d$ is the euclidean dimension of the space where the fractal is embedded. The physical restriction $D 1$ in a fractal set. The average size $\\bar \\Lambda$ of voids depends on the upper ($\\Lambda_u$) and the lower ($\\Lambda_l$) cut-off as ${\\bar \\Lambda} \\propto \\Lambda_u^{1-D/d} \\Lambda_l^{D/d}$. Current analysis of v...

  19. Relation Between Rheumatoid Arthritis and Hearing Disorders

    Directory of Open Access Journals (Sweden)

    A Doosti

    2007-07-01

    Full Text Available Introduction: Some of the studies have shown that RA (Rheumatoid Arthritis may cause hearing disorders. These disorders can result in problems later in life, so survey of correlation between rheumatoid arthritis and hearing disorders is important . Methods: This was a case-control study which has done from December 2004 to August 2006 at Shaheed Sadoughi hospital in Yazd. In this study, 50 Rheumatoid arthritis patients as case group (100 ears with 50 persons as control group who were of the same age, sex and job (100 ears were compared. Results: Patients were 21-67 years old and the mean age was 47.58 years(It was the same as the control group.From 50 cases (controls 42 were women and 8 were men . Audiometric tests in different frequencies showed that hearing loss in high frequencies, especially in 8000 Hz was significantly different in the two groups. Also, acoustic reflex was absent in case group and this too was significantly different.The evaluation of sensory neural hearing loss showed that this hearing loss was sensory, not neural . Conclusion: In Rheumatoid arthritis, middle and inner ear disorders have been shown. But some patients aren't aware of their hearing loss and they have no clinical complains, so frequent evaluation of audiometric tests is recommended. Hearing disorders can be controlled by therapeutic and rehabilitation procedures in these patients.

  20. On cavitation instabilities with interacting voids

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2012-01-01

    voids so far apart that the radius of the plastic zone around each void is less than 1% of the current spacing between the voids, can still affect each others at the occurrence of a cavitation instability such that one void stops growing while the other grows in an unstable manner. On the other hand...

  1. Alignment of voids in the cosmic web

    NARCIS (Netherlands)

    Platen, Erwin; van de Weygaert, Rien; Jones, Bernard J. T.

    2008-01-01

    We investigate the shapes and mutual alignment of voids in the large-scale matter distribution of a Lambda cold dark matter (Lambda CDM) cosmology simulation. The voids are identified using the novel watershed void finder (WVF) technique. The identified voids are quite non-spherical and slightly pro

  2. Alignment of voids in the cosmic web

    NARCIS (Netherlands)

    Platen, Erwin; van de Weygaert, Rien; Jones, Bernard J. T.

    2008-01-01

    We investigate the shapes and mutual alignment of voids in the large-scale matter distribution of a Lambda cold dark matter (Lambda CDM) cosmology simulation. The voids are identified using the novel watershed void finder (WVF) technique. The identified voids are quite non-spherical and slightly

  3. Work Related Musculoskeletal Disorders in Scaffolders

    NARCIS (Netherlands)

    L.A.M. Elders (Leo)

    2003-01-01

    textabstractIn many occupational populations, musculoskeletal disorders constitute an important source of morbidity, sickness absence, and disability and attribute to a substantial social and economic burden for society. This is certainly applicable to scaffolders, the study population in this thesi

  4. Anxiety and Related Disorders in Men

    DEFF Research Database (Denmark)

    Grant, Joe E.; Odlaug, Brian Lawrence

    2015-01-01

    (Baxter et al. 2013 ). Per year, the estimated cost (directly and indirectly) of anxiety disorders in the United States alone is over $42 billion (Greenberg et al. 1999 ). More than 50 % of these expenses are due to clinical care stemming from misdiagnosis, inadequate treatment, and emergency care...

  5. Precision cosmography with stacked voids

    CERN Document Server

    Lavaux, Guilhem

    2011-01-01

    We present a purely geometrical method for probing the expansion history of the Universe from the observation of the shape of stacked voids in spectroscopic re dshift surveys. Our method is an Alcock-Pasczinsky test based on the average sphericity of voids posited on the local isotropy of the Universe. It works by comparing the temporal extent of cosmic voids along the line of sight with their angular, spatial extent. We describe the algorithm that we use to detect and stack voids in redshift shells on the light cone and test it on mock light cones produced from N-body simulations. We establish a robust statistical model for estimating the average stretching of voids in redshift space and quantify the contamination by peculiar velocities. Finally, we assess the capability of this approach to constrain dark energy parameters in terms of the figure of merit (FoM) of the dark energy task force and in particular of the proposed Euclid mission which is particularly suited for this technique since it is a spectrosc...

  6. Myofascial Pelvic Pain and Related Disorders.

    Science.gov (United States)

    Bonder, Jaclyn H; Chi, Michelle; Rispoli, Leia

    2017-08-01

    Myofascial pelvic pain refers to pain in the pelvic floor muscles, the pelvic floor connective tissue, and the surrounding fascia. The cause is often multifactorial and requires treatment that encompasses multiple modalities. This type of pain is often associated with other abdominopelvic disorders, so providers in these specialties need to be aware of these connections. A comprehensive musculoskeletal examination, including evaluation of the pelvic floor muscles, and history are key to diagnosing myofascial pelvic pain. Treatments include physical therapy, muscle relaxers, oral neuromodulators, cognitive-behavioral therapy, and pelvic floor muscle injections. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Measurements of gas pressure in voids in epoxy castings for high voltage equipment

    DEFF Research Database (Denmark)

    Larsen, Esben; Henriksen, Mogens; Nielsen, E

    1988-01-01

    the partial-discharge inception voltage. Data show that gas pressure in voids in epoxy castings can be determined by use of an ultrasound test method. A relationship between the void gas pressure and the epoxy curing pressure is also found. This investigation is part of an effort to predict the inception......An investigation of samples of epoxy each containing one void, which were produced at different pressures, is reported. The samples were of the disk type with the void located in the center. The gas in the voids has a pressure somewhat related to the curing pressure, thereby directly influencing...

  8. Melatonin in Mitochondrial Dysfunction and Related Disorders

    Directory of Open Access Journals (Sweden)

    Venkatramanujam Srinivasan

    2011-01-01

    Full Text Available Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R, septic shock, and neurodegenerative disorders like Parkinson's disease (PD, Alzheimer's disease (AD, and Huntington's disease (HD. Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO synthase activity, enhanced NO production, decreased respiratory complex activity, impaired electron transport system, and opening of mitochondrial permeability transition pore all have been suggested as factors responsible for impaired mitochondrial function. Melatonin, the major hormone of the pineal gland, also acts as an antioxidant and as a regulator of mitochondrial bioenergetic function. Both in vitro and in vivo, melatonin was effective for preventing oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD. In addition, melatonin is known to retard aging and to inhibit the lethal effects of septic shock or I/R lesions by maintaining respiratory complex activities, electron transport chain, and ATP production in mitochondria. Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other antioxidants. Melatonin has thus emerged as a major potential therapeutic tool for treating neurodegenerative disorders such as PD or AD, and for preventing the lethal effects of septic shock or I/R.

  9. "Compu-Void II": the computerized voiding diary.

    Science.gov (United States)

    Rabin, J M; McNett, J; Badlani, G H

    1996-02-01

    We have previously described an electronic voiding diary, "Compu-Void" (Copyright, 1990) developed to automate recording of bladder symptoms (Rabin et al., 1993). Our objectives in this, the second phase of this study, were to examine a group of subject and control patients' preference and compliance with regard to the "Compu-Void" (CV) compared to the standard written voiding diary (WD), to compare the two methods with respect to the amount and type of information obtained and to determine whether or not the order of use of each recording method influenced results in the subject group. Thirty-six women between the ages of 20 and 84 with bladder symptomatology were compared to a group 36 age-matched women. In 100% of subjects and 95% of control patients, CV entries exceeded the number made with the WD in voiding events and in subjects, in incontinent episodes recorded (P < 0.0005 and P < 0.005, respectively). Over 98% of subjects and over 80% of control patients preferred CV over the WD (p < 0.0005). The order of use of each recording method in subjects made no significant difference with regard to the volume of information obtained (p < 0.407), number of urinary leakage events recorded (p < 0.494), and fluid intake patterns (p < 0.410). Patient impressions of, and compliance with each method were not affected by order of use. The only difference regarding order of use was that most subjects who used the CV first also found the WD to be tedious (61% vs 14%). Our results suggest increased volume of data and of patient compliance in reporting bladder symptoms and events using CV, and that order of use is not an important factor in determining patient impressions of the two methods. The majority of subject and control patients preferred CV over traditional methods. An updated version of the software and hardware is also included.

  10. Molecular Gas and Star Formation in Voids

    CERN Document Server

    Das, M; Iono, D; Honey, M; Ramya, S

    2014-01-01

    We present the detection of molecular gas using CO(1-0) line emission and follow up Halpha imaging observations of galaxies located in nearby voids. The CO(1-0) observations were done using the 45m telescope of the Nobeyama Radio Observatory (NRO) and the optical observations were done using the Himalayan Chandra Telescope (HCT). Although void galaxies lie in the most under dense parts of our universe, a significant fraction of them are gas rich, spiral galaxies that show signatures of ongoing star formation. Not much is known about their cold gas content or star formation properties. In this study we searched for molecular gas in five void galaxies using the NRO. The galaxies were selected based on their relatively higher IRAS fluxes or Halpha line luminosities. CO(1--0) emission was detected in four galaxies and the derived molecular gas masses lie between (1 - 8)E+9 Msun. The H$\\alpha$ imaging observations of three galaxies detected in CO emission indicates ongoing star formation and the derived star forma...

  11. Plasma kynurenine and related measures in tic disorder patients

    NARCIS (Netherlands)

    Hoekstra, Pieter J.; Anderson, George M.; Troost, Pieter W.; Kallenberg, Cees G. M.; Minderaa, Ruud B.

    2007-01-01

    Objective Increased plasma kynurenine has been reported in tic disorder patients, and this observation has been suggested to be indicative of immune dysregulation. In the present study, we examined plasma levels of kynurenine and related molecules in a group of tic disorder patients. Methods Plasma

  12. Plasma kynurenine and related measures in tic disorder patients

    NARCIS (Netherlands)

    Hoekstra, Pieter J.; Anderson, George M.; Troost, Pieter W.; Kallenberg, Cees G. M.; Minderaa, Ruud B.

    2007-01-01

    Objective Increased plasma kynurenine has been reported in tic disorder patients, and this observation has been suggested to be indicative of immune dysregulation. In the present study, we examined plasma levels of kynurenine and related molecules in a group of tic disorder patients. Methods Plasma

  13. Plasma kynurenine and related measures in tic disorder patients

    NARCIS (Netherlands)

    Hoekstra, Pieter J.; Anderson, George M.; Troost, Pieter W.; Kallenberg, Cees G. M.; Minderaa, Ruud B.

    Objective Increased plasma kynurenine has been reported in tic disorder patients, and this observation has been suggested to be indicative of immune dysregulation. In the present study, we examined plasma levels of kynurenine and related molecules in a group of tic disorder patients. Methods Plasma

  14. Combinations of SNPs related to signal transduction in bipolar disorder

    DEFF Research Database (Denmark)

    Koefoed, Pernille; Andreassen, Ole A; Bennike, Bente

    2011-01-01

    of complex diseases, it may be useful to look at combinations of genotypes. Genes related to signal transmission, e.g., ion channel genes, may be of interest in this respect in the context of bipolar disorder. In the present study, we analysed 803 SNPs in 55 genes related to aspects of signal transmission...... and calculated all combinations of three genotypes from the 3×803 SNP genotypes for 1355 controls and 607 patients with bipolar disorder. Four clusters of patient-specific combinations were identified. Permutation tests indicated that some of these combinations might be related to bipolar disorder. The WTCCC...

  15. Prevalence of substance-related disorders in heart transplantation candidates.

    Science.gov (United States)

    Sirri, L; Potena, L; Masetti, M; Tossani, E; Grigioni, F; Magelli, C; Branzi, A; Grandi, S

    2007-01-01

    Substance abuse cessation is one of the leading factors in determining the eligibility for the heart transplantation waiting list, as noncompliance with this issue may seriously endanger posttransplantation outcomes. Yet, the prevalence of substance-related disorders among candidates for heart transplantation has not been evaluated enough. Eighty three heart transplantation candidates were assessed for prior or current substance-related disorders through the Structured Clinical Interview for mental disorders according to DSM-IV. A prior history of at least one substance-related disorder was found in 64% of patients, with nicotine dependence as the most prevalent diagnosis (61.4% of the sample). Ten subjects were currently smokers, despite heart failure. A prior history of alcohol abuse and caffeine intoxication was found in 9.6% and 2.4% of patients, respectively. Substance abuse or dependence behaviors should be monitored during all the phases of heart transplantation program. Early identification of current substance-related disorders may allow better allocation of organ resources and proper lifestyle modification programs provision. A prior history of substance-related disorders should alert physicians to assess patients for possible relapse, especially after transplantation. The inclusion of a specialist in the assessment and treatment of substance-related disorders in the heart transplantation unit may reduce the risk of unsuccessful outcomes due to noncompliance with an adequate lifestyle.

  16. State-related alterations of gene expression in bipolar disorder

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Vinberg, Maj; Berk, Michael

    2012-01-01

    Munkholm K, Vinberg M, Berk M, Kessing LV. State-related alterations of gene expression in bipolar disorder: a systematic review. Bipolar Disord 2012: 14: 684-696. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objective:  Alterations in gene expression in bipolar disorder...... on comprehensive database searches for studies on gene expression in patients with bipolar disorder in specific mood states, was conducted. We searched Medline, Embase, PsycINFO, and The Cochrane Library, supplemented by manually searching reference lists from retrieved publications. Results:  A total of 17...

  17. Agoraphobia Related to Unassertiveness in Panic Disorder.

    Science.gov (United States)

    Levitan, Michelle Nigri; Simoes, Pedro; Sardinha, Aline G; Nardi, Antonio E

    2016-05-01

    Despite developments in panic disorder (PD) research, a significant percentage of patients do not benefit from conventional treatments. Interpersonal factors have been identified as potential predictors of treatment failures. We aimed to evaluate assertiveness in a sample of patients with PD and its implications for treatment. Forty-six symptomatic patients with PD and 46 college students responded to assessment scales regarding assertiveness and clinical data. Seventy-five percent of the patients had a secondary diagnosis of agoraphobia. We found that the PD group was characterized as nonassertive and slightly less assertive than control subjects. Furthermore, the deficit in the level of assertiveness correlated with the severity of the PD. The diagnosis of agoraphobia was correlated with unassertiveness (p Agoraphobia predisposes individuals to dependency and insecurity about their ability to overcome anxiogenic situations. These data demonstrate the importance of managing assertiveness in patients with PD accompanied by agoraphobia.

  18. [Marfan syndrome and related connective tissue disorders].

    Science.gov (United States)

    Steindl, Katharina

    2013-11-27

    Marfan syndrome is an autosomal dominantly inherited connective tissue disorder with a prevalence of approximately 1:5000 people. Typical manifestations affect the cardiovascular system, eyes, skeleton, lungs, skin and dura mater. Most patients have a so-called marfanoid habitus with tall stature, long and narrow limbs, a long and narrow head shape and other skeletal abnormalities. Of particular medical importance are the possible complications such as severe scoliosis or pectus excavatum, spontaneous pneumothorax, retinal detachment, or an acute glaucoma evoked by lens luxation. However, the most dangerous complication is acute dissection of the ascending aorta, which is usually the result of a slowly progressive aortic dilatation. With the introduction of therapies the average life expectancy of previously just 32 years could be raised to above 60 years.

  19. Isolation and control of voids and void-hillocks during molecular beam epitaxial growth of HgCdTe

    Science.gov (United States)

    Chandra, D.; Aqariden, F.; Frazier, J.; Gutzler, S.; Orent, T.; Shih, H. D.

    2000-06-01

    Formation of small voids and defect complexes involving small voids during the molecular beam epitaxial growth of mercury cadmium telluride on cadmium zinc telluride was investigated. Some of these defects were demonstrated to form away from the substrate-epi interface. Other defects were demonstrated to close before reaching the top surface without leaving any perturbations on the surface, thus remaining completely hidden. The voids, which formed away from the substrate-epifilm fixed interface, nucleated on defects introduced into the film already grown, leading to the formation of defect complexes, unlike the voids which nucleated at the substrate-epifilm fixed interface. These defect complexes are decorated with high density dislocation nests. The voids which closed before reaching the film surface usually also nucleated slightly away from the film-substrate interface, continued to replicate for a while as the growth progressed, but then relatively rapidly closed off at a significant depth from the film surface. These voids also appeared to form defect complexes with other kinds of defects. Correlations between these materials defects and performance of individual vertically integrated photodiode (VIP) devices were demonstrated, where the relative location of these defects with respect to the junction boundary appears to be particularly important. Elimination or reduction of fluctuations in relative flux magnitudes or substrate temperature, more likely during multi-composition layer growth, yielded films with significantly lower defect concentrations.

  20. Low and High Surface Brightness Galaxies at Void Walls

    CERN Document Server

    Ceccarelli, L; Lambas, D G; Galaz, G; Padilla, N D

    2012-01-01

    We study the relative fraction of low and high surface brightness galaxies (LSBGs and HSBGs) at void walls in the SDSS DR7. We focus on galaxies in equal local density environments. We assume that the host dark-matter halo mass (for which we use SDSS group masses) is a good indicator of local density. This analysis allows to examine the behavior of the abundance of LSBG and HSBG galaxies at a fixed local density and distinguish the large-scale environment defined by the void geometry. We compare galaxies in the field, and in the void walls; the latter are defined as the volume of void shells of radius equal to that of the void. We find a significant decrement, a factor $\\sim 4$, of the relative fraction of blue, active star-forming LSBGs in equal mass groups at the void walls and the field. This decrement is consistent with an increase of the fraction of blue, active star-forming HSBGs. By contrast, red LSBGs and HSBGs show negligible changes. We argue that these results are consistent with a scenario where L...

  1. Hepatic perfusion disorders: Etiopathogenesis and related diseases

    Institute of Scientific and Technical Information of China (English)

    Jin-Lin Tian; Jin-Shan Zhang

    2006-01-01

    In this article, we have reviewed the hepatic perfusion disorder (HPD), etiopathogenesis of HPD and corresponding diseases. Review of the literature was based on computer searches (PubMed, Index Medicus)and personal experiences. We considered HPD reflects perfusion differences due to redistribution of arterial blood flow among segments, subsegments and lobes of the liver. The plain CT scan findings of HPD manifests as triangular or wedge-shaped areas of low attenuation.On contrast-enhanced CT scan, HPD manifests multiple (or single) transient wedge-shaped, rotundloid or irregular appearance, homogeneous hyperattenuation (in less cases, hypoattenuation) during the hepatic arterial phase (HAP) and isoattenuated or slightly hyperattenuated areas during the portal arterial phase.Dynamic enhanced magnetic resonance (MR) features are similar to enhanced CT scan. Angiographic findings include non-opacification of portal vein on portograms or wedge-shaped segmental staining in arterial and parenchymal phases on hepatic angiograms. The causes of HPD are arterioportal shunts (APS), intrahepatic vascular compressions and portal vein occlusion,steal phenomenon by hypervascular tumors, vascular variations and any other unknown reasons. It is very important for radiologists to be familiar with the various appearances of HPD to avoid false-positive diagnosis of pseudolesions and not to overestimate the extent of the disease.

  2. [Substance-related and addictive disorders in the DSM-5].

    Science.gov (United States)

    Thomasius, Rainer; Sack, Peter-Michael; Strittmatter, Esther; Kaess, Michael

    2014-03-01

    This paper concerns the revised classification of Substance-Related and Addictive Disorders in the fifth edition of the American Psychiatric Association's (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5). In DSM-5, substance use disorders are diagnosed on a continuum of severity specified by explicit operationalized diagnostic criteria. "Gambling disorder" is the only behavioral addiction added to the DSM. Furthermore, preliminary criteria for "Caffeine Use Disorder" and "Internet Gaming Disorder" have now been defined in the manual. Adopting the DSM-5 criteria catalogue within the German treatment system for children and adolescents with substance use disorders or at risk for developing substance use disorders would be of great significance. Since the diagnostic threshold is lower, more patients would be eligible for treatment. Thus, early intervention in the area of substance use disorders should be strengthened, a development that appears to be highly desirable from the perspective of child and adolescent psychiatry. The current Section III diagnoses, with their now comprehensive diagnostic criteria, facilitate more internationally compatible research.

  3. Coupling effects of void size and void shape on the growth of prolate ellipsoidal microvoid

    Institute of Scientific and Technical Information of China (English)

    Minsheng Huang; Zhenhuan Li; Cheng Wang

    2005-01-01

    The combined effects of void size and void shape on the void growth are studied by using the classical spectrum method. An infinite solid containing an isolated prolate spheroidal void is considered to depict the void shape effect and the Fleck-Hutchinson phenomenological strain gradient plasticity theory is employed to capture the size effects. It is found that the combined effects of void size and void shape are mainly controlled by the remote stress triaxiality. Based on this, a new size-dependent void growth model similar to the Rice-Tracey model is proposed and an important conclusion about the size-dependent void growth is drawn: the growth rate of the void with radius smaller than a critical radius rc may be ignored. It is interesting that rc is a material constant independent of the initial void shape and the remote stress triaxiality.

  4. The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.

    Science.gov (United States)

    Smoller, Jordan W

    2016-01-01

    Research into the causes of psychopathology has largely focused on two broad etiologic factors: genetic vulnerability and environmental stressors. An important role for familial/heritable factors in the etiology of a broad range of psychiatric disorders was established well before the modern era of genomic research. This review focuses on the genetic basis of three disorder categories-posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and the anxiety disorders-for which environmental stressors and stress responses are understood to be central to pathogenesis. Each of these disorders aggregates in families and is moderately heritable. More recently, molecular genetic approaches, including genome-wide studies of genetic variation, have been applied to identify specific risk variants. In this review, I summarize evidence for genetic contributions to PTSD, MDD, and the anxiety disorders including genetic epidemiology, the role of common genetic variation, the role of rare and structural variation, and the role of gene-environment interaction. Available data suggest that stress-related disorders are highly complex and polygenic and, despite substantial progress in other areas of psychiatric genetics, few risk loci have been identified for these disorders. Progress in this area will likely require analysis of much larger sample sizes than have been reported to date. The phenotypic complexity and genetic overlap among these disorders present further challenges. The review concludes with a discussion of prospects for clinical translation of genetic findings and future directions for research.

  5. ANALYSIS OF THYRIOD DISORDER AND ITS RELATION WITH GIOTROGENS

    Directory of Open Access Journals (Sweden)

    Sreedevi

    2015-07-01

    Full Text Available OBJECTIVE: Evaluate the prevalence of thyroid disorder and sensitise women patients about thyroid health and its relation with goitrogenic foods. Method: By random selection method 300 female patients who attended outpatient clinic were subjected to thyroid Function test ( T3, T4, TSH and USG NECK. A questionnaire relating thyroid disorders and gaitrogens were given to them and analysis was done. RESULT: The results show prevalence of hypothyroidism is 7.3%, Goitre is 4% and hyper thyroidism is 0.6%. Analysis of ques tionnaire shows that though 81% of women population use iodised salt, 80% of women population are not aware of goitrogenic foods and its relation to thyroid disorder. CONCLUSION: Though implementation of universal salt iodisation was done in 1986, awarenes s of goitrogenic foods and its relevance to thyroid disorder is not known to women. Hence sensitisation of women population should be enhanced.

  6. The molecular genetics of Marfan syndrome and related disorders

    Science.gov (United States)

    Robinson, P N; Arteaga‐Solis, E; Baldock, C; Collod‐Béroud, G; Booms, P; De Paepe, A; Dietz, H C; Guo, G; Handford, P A; Judge, D P; Kielty, C M; Loeys, B; Milewicz, D M; Ney, A; Ramirez, F; Reinhardt, D P; Tiedemann, K; Whiteman, P; Godfrey, M

    2006-01-01

    Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of connective tissue with prominent manifestations in the skeletal, ocular, and cardiovascular systems, is caused by mutations in the gene for fibrillin‐1 (FBN1). The leading cause of premature death in untreated individuals with MFS is acute aortic dissection, which often follows a period of progressive dilatation of the ascending aorta. Recent research on the molecular physiology of fibrillin and the pathophysiology of MFS and related disorders has changed our understanding of this disorder by demonstrating changes in growth factor signalling and in matrix‐cell interactions. The purpose of this review is to provide a comprehensive overview of recent advances in the molecular biology of fibrillin and fibrillin‐rich microfibrils. Mutations in FBN1 and other genes found in MFS and related disorders will be discussed, and novel concepts concerning the complex and multiple mechanisms of the pathogenesis of MFS will be explained. PMID:16571647

  7. CT measurements of SAP voids in concrete

    DEFF Research Database (Denmark)

    Laustsen, Sara; Bentz, Dale P.; Hasholt, Marianne Tange

    2010-01-01

    X-ray computed tomography (CT) scanning is used to determine the SAP void distribution in hardened concrete. Three different approaches are used to analyse a binary data set created from CT measurement. One approach classifies a cluster of connected, empty voxels (volumetric pixel of a 3D image......) as one void, whereas the other two approaches are able to classify a cluster of connected, empty voxels as a number of individual voids. Superabsorbent polymers (SAP) have been used to incorporate air into concrete. An advantage of using SAP is that it enables control of the amount and size...... of the created air voids. The results indicate the presence of void clusters. To identify the individual voids, special computational approaches are needed. The addition of SAP results in a dominant peak in two of the three air void distributions. Based on the position (void diameter) of the peak, it is possible...

  8. CT measurements of SAP voids in concrete

    DEFF Research Database (Denmark)

    Laustsen, Sara; Bentz, Dale P.; Hasholt, Marianne Tange;

    2010-01-01

    X-ray computed tomography (CT) scanning is used to determine the SAP void distribution in hardened concrete. Three different approaches are used to analyse a binary data set created from CT measurement. One approach classifies a cluster of connected, empty voxels (volumetric pixel of a 3D image......) as one void, whereas the other two approaches are able to classify a cluster of connected, empty voxels as a number of individual voids. Superabsorbent polymers (SAP) have been used to incorporate air into concrete. An advantage of using SAP is that it enables control of the amount and size...... of the created air voids. The results indicate the presence of void clusters. To identify the individual voids, special computational approaches are needed. The addition of SAP results in a dominant peak in two of the three air void distributions. Based on the position (void diameter) of the peak, it is possible...

  9. Electronegativity and intrinsic disorder of preeclampsia-related proteins.

    Science.gov (United States)

    Polanco, Carlos; Castañón-González, Jorge Alberto; Uversky, Vladimir N; Buhse, Thomas; Samaniego Mendoza, José Lino; Calva, Juan J

    2017-01-01

    Preeclampsia, hemorrhage, and infection are the leading causes of maternal death in underdeveloped countries. Since several proteins associated with preeclampsia are known, we conducted a computational study which evaluated the commonness and potential functionality of intrinsic disorder of these proteins and also made an attempt to characterize their origin. The origin of the preeclampsia-related proteins was assessed with a supervised technique, a Polarity Index Method (PIM), which evaluates the electronegativity of proteins based solely on their sequence. The commonness of intrinsic disorder was evaluated using several disorder predictors from the PONDR family, the charge-hydropathy plot (CH-plot) and cumulative distribution function (CDF) analyses, and using the MobiDB web-based tool, whereas potential functionality of intrinsic disorder was studied with the D2P2 resource and ANCHOR predictor of disorder-based binding sites, and the STRING tool was used to build the interactivity networks of the preeclampsia-related proteins. Peculiarities of the PIM-derived polar profile of the group of preeclampsia-related proteins were then compared with profiles of a group of lipoproteins, antimicrobial peptides, angiogenesis-related proteins, and the intrinsically disordered proteins. Our results showed a high graphical correlation between preeclampsia proteins, lipoproteins, and the angiogenesis proteins. We also showed that many preeclampsia-related proteins contain numerous functional disordered regions. Therefore, these bioinformatics results led us to assume that the preeclampsia proteins are highly associated with the lipoproteins group, and that some preeclampsia-related proteins contain significant amounts of functional disorders.

  10. Vertical Craniofacial Morphology and its Relation to Temporomandibular Disorders

    Directory of Open Access Journals (Sweden)

    Paula Furlan Bavia

    2016-06-01

    Full Text Available Objectives: This study investigated the association between craniofacial morphology and temporomandibular disorders in adults. The influence of different craniofacial morphologies on painful temporomandibular disorders was also evaluated. Material and Methods: A total of 200 subjects were selected, including 100 with temporomandibular disorders (TMD and 100 without TMD (control, diagnosed by research diagnostic criteria for temporomandibular disorders. All subjects were submitted to lateral cephalometric radiographs, and classified as brachyfacial, mesofacial, or dolichofacial by Ricketts’ analysis. Data were analysed by Tukey-Kramer and Chi-square tests. Results: No association between craniofacial morphology and TMD was found (P = 0.6622. However, brachyfacial morphology influences the presence of painful TMD (P = 0.0077. Conclusions: Craniofacial morphology is not related to temporomandibular disorders in general.

  11. Health Related Quality Of Life In Patents With Spinal Disorders

    Directory of Open Access Journals (Sweden)

    Kamath Prakash

    2003-01-01

    Full Text Available Spinal disorders are the major cause of disability and poor Quality Of Life (QoL. This study attempted to measure Health Related Quality Of Life (HRQoL Spinal disorders using a brief, generic scale. Consecutive subjects with spinal disorders (n=102 were interviewed using two scales Karnofsky Performance Status, Euro QoL EQ-5D and two statements from WHOQoL-Bref. The study found that the overall HRQoL in spinal disorders is not so good in most of the patients. Pain and impaired mobility maximally contributed to the poor HRQoL. Socio demographic factors like age, education, habitat had significant relationship with HRQoL scores. Average time taken for HRQoL measurement was less than 5 minutes. In conclusion HRQoL in spinal disorders is generally not so good and brief generic scales to measure HRQOL can prove to be useful for routine use.

  12. Size-Effects in Void Growth

    DEFF Research Database (Denmark)

    Niordson, Christian Frithiof

    2005-01-01

    The size-effect on ductile void growth in metals is investigated. The analysis is based on unit cell models both of arrays of cylindrical voids under plane strain deformation, as well as arrays of spherical voids using an axisymmetric model. A recent finite strain generalization of two higher order...

  13. Relational Aggression in Children with Preschool Onset (PO) Psychiatric Disorders

    Science.gov (United States)

    Belden, Andy C.; Gaffrey, Michael S.; Luby, Joan L.

    2012-01-01

    Objective The role of preschool onset (PO) psychiatric disorders as correlates and/or risk factors for relational aggression during kindergarten or 1st grade was tested in a sample of N = 146 preschool-age children (3 to 5.11). Method Axis-I diagnoses and symptom scores were derived using the Preschool Age Psychiatric Assessment. Children’s roles in relational aggression as aggressor, victim, aggressive-victim, or non-aggressor/non-victim were determined at preschool and again 24 months later at elementary school entry. Results Preschoolers diagnosed with PO-psychiatric disorders were 3 times as likely as the healthy preschoolers to be classified aggressors, victims, or aggressive-victims. Children diagnosed with PO-disruptive, depressive, and/or anxiety disorders were at least 6 times as likely as children without PO-psychiatric disorders to become aggressive-victims during elementary school after covarying for other key risk factors. Conclusions Findings suggested that PO-psychiatric disorders differentiated preschool and school-age children’s roles in relational aggression based on teacher-report. Recommendations for future research and preventative intervention aimed at minimizing the development of relational aggression in early childhood by identifying and targeting PO-psychiatric disorders are made. PMID:22917202

  14. Anxiety sensitivity mediates relations between emotional disorders and smoking.

    Science.gov (United States)

    Zvolensky, Michael J; Farris, Samantha G; Leventhal, Adam M; Schmidt, Norman B

    2014-09-01

    Research has documented consistent and robust relations between emotional disorders (i.e., depressive and anxiety disorders) and smoking. Yet, it is presently unclear whether anxiety sensitivity--the fear of aversive internal anxiety states--accounts for the relations between emotional disorders and various smoking processes, including nicotine dependence, perceived barriers to smoking cessation, and severity of problematic symptoms during past cessation attempts. Participants (N = 465) were treatment-seeking daily tobacco smokers recruited as part of a larger tobacco-cessation study. Baseline (pretreatment) data were utilized. Emotional disorders were assessed via clinical diagnostic interview; self-report measures were used to assess anxiety sensitivity and 3 criterion variables: nicotine dependence, barriers to smoking cessation, and severity of problematic symptoms while quitting in past attempts. Emotional disorders were predictive of higher levels of nicotine dependence, greater perceived barriers to cessation, and greater severity of problematic symptoms while attempting to quit in the past; each of these relations were accounted for by the indirect effect of anxiety sensitivity. The present findings suggest that anxiety sensitivity may be an important transdiagnostic construct in explicating the nature of the relations between emotional disorders and various smoking processes.

  15. HCV-Related Nervous System Disorders

    Directory of Open Access Journals (Sweden)

    Salvatore Monaco

    2012-01-01

    Full Text Available Chronic infection with hepatitis C virus (HCV is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms responsible for nervous system dysfunction are mainly related to the upregulation of the host immune response with production of autoantibodies, immune complexes, and cryoglobulins. Alternative mechanisms include possible extrahepatic replication of HCV in neural tissues and the effects of circulating inflammatory cytokines and chemokines.

  16. OBSESSIVE–COMPULSIVE DISORDER VERSUS BODY DYSMORPHIC DISORDER: A COMPARISON STUDY OF TWO POSSIBLY RELATED DISORDERS

    OpenAIRE

    Phillips, Katharine A.; Pinto, Anthony; Menard, William; Eisen, Jane L.; Mancebo, Maria; Rasmussen, Steven A.

    2007-01-01

    The relationship between obsessive–compulsive disorder (OCD) and body dysmorphic disorder (BDD) is unclear. BDD has been proposed to be an OCD-spectrum disorder or even a type of OCD. However, few studies have directly compared these disorders’ clinical features. We compared characteristics of subjects with OCD (n = 210), BDD (n = 45), and comorbid BDD/OCD (n = 40). OCD and BDD did not significantly differ in terms of demographic features, age of OCD or BDD onset, illness duration, and many o...

  17. Constitutive modeling of rate dependence and microinertia effects in porous-plastic materials with multi-sized voids (MSVs)

    KAUST Repository

    Liu, Jinxing

    2012-11-27

    Micro-voids of varying sizes exist in most metals and alloys. Both experiments and numerical studies have demonstrated the critical influence of initial void sizes on void growth. The classical Gurson-Tvergaard-Needleman model summarizes the influence of voids with a single parameter, namely the void-volume fraction, excluding any possible effects of the void-size distribution. We extend our newly proposed model including the multi-sized void (MSV) effect and the void-interaction effect for the capability of working for both moderate and high loading rate cases, where either rate dependence or microinertia becomes considerable or even dominant. Parametric studies show that the MSV-related competitive mechanism among void growth leads to the dependence of the void growth rate on void size, which directly influences the void\\'s contribution to the total energy composition. We finally show that the stress-strain constitutive behavior is also affected by this MSV-related competitive mechanism. The stabilizing effect due to rate sensitivity and microinertia is emphasized. © 2013 IOP Publishing Ltd.

  18. Abnormal brain activation and connectivity to standardized disorder-related visual scenes in social anxiety disorder.

    Science.gov (United States)

    Heitmann, Carina Yvonne; Feldker, Katharina; Neumeister, Paula; Zepp, Britta Maria; Peterburs, Jutta; Zwitserlood, Pienie; Straube, Thomas

    2016-04-01

    Our understanding of altered emotional processing in social anxiety disorder (SAD) is hampered by a heterogeneity of findings, which is probably due to the vastly different methods and materials used so far. This is why the present functional magnetic resonance imaging (fMRI) study investigated immediate disorder-related threat processing in 30 SAD patients and 30 healthy controls (HC) with a novel, standardized set of highly ecologically valid, disorder-related complex visual scenes. SAD patients rated disorder-related as compared with neutral scenes as more unpleasant, arousing and anxiety-inducing than HC. On the neural level, disorder-related as compared with neutral scenes evoked differential responses in SAD patients in a widespread emotion processing network including (para-)limbic structures (e.g. amygdala, insula, thalamus, globus pallidus) and cortical regions (e.g. dorsomedial prefrontal cortex (dmPFC), posterior cingulate cortex (PCC), and precuneus). Functional connectivity analysis yielded an altered interplay between PCC/precuneus and paralimbic (insula) as well as cortical regions (dmPFC, precuneus) in SAD patients, which emphasizes a central role for PCC/precuneus in disorder-related scene processing. Hyperconnectivity of globus pallidus with amygdala, anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) additionally underlines the relevance of this region in socially anxious threat processing. Our findings stress the importance of specific disorder-related stimuli for the investigation of altered emotion processing in SAD. Disorder-related threat processing in SAD reveals anomalies at multiple stages of emotion processing which may be linked to increased anxiety and to dysfunctionally elevated levels of self-referential processing reported in previous studies. © 2016 Wiley Periodicals, Inc.

  19. Sodium voiding analysis in Kalimer

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Won-Pyo; Jeong, Kwan-Seong; Hahn, Dohee [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2001-07-01

    A sodium boiling model has been developed for calculations of the void reactivity feedback as well as the fuel and cladding temperatures in the KALIMER core after onset of sodium boiling. The sodium boiling in liquid metal reactors using sodium as coolant should be modeled because of phenomenon difference observed from that in light water reactor systems. The developed model is a multiple -bubble slug ejection model. It allows a finite number of bubbles in a channel at any time. Voiding is assumed to result from formation of bubbles that fill the whole cross section of the coolant channel except for liquid film left on the cladding surface. The vapor pressure, currently, is assumed to be uniform within a bubble. The present study is focused on not only demonstration of the sodium voiding behavior predicted by the developed model, but also confirmation on qualitative acceptance for the model. In results, the model catches important phenomena for sodium boiling, while further effort should be made for the complete analysis. (author)

  20. Redshift-space distortions around voids

    Science.gov (United States)

    Cai, Yan-Chuan; Taylor, Andy; Peacock, John A.; Padilla, Nelson

    2016-11-01

    We have derived estimators for the linear growth rate of density fluctuations using the cross-correlation function (CCF) of voids and haloes in redshift space. In linear theory, this CCF contains only monopole and quadrupole terms. At scales greater than the void radius, linear theory is a good match to voids traced out by haloes; small-scale random velocities are unimportant at these radii, only tending to cause small and often negligible elongation of the CCF near its origin. By extracting the monopole and quadrupole from the CCF, we measure the linear growth rate without prior knowledge of the void profile or velocity dispersion. We recover the linear growth parameter β to 9 per cent precision from an effective volume of 3( h-1Gpc)3 using voids with radius >25 h-1Mpc. Smaller voids are predominantly sub-voids, which may be more sensitive to the random velocity dispersion; they introduce noise and do not help to improve measurements. Adding velocity dispersion as a free parameter allows us to use information at radii as small as half of the void radius. The precision on β is reduced to 5 per cent. Voids show diverse shapes in redshift space, and can appear either elongated or flattened along the line of sight. This can be explained by the competing amplitudes of the local density contrast, plus the radial velocity profile and its gradient. The distortion pattern is therefore determined solely by the void profile and is different for void-in-cloud and void-in-void. This diversity of redshift-space void morphology complicates measurements of the Alcock-Paczynski effect using voids.

  1. [Trauma-related disorders in patients with borderline personality disorders. Results of a multicenter study].

    Science.gov (United States)

    Sack, M; Sachsse, U; Overkamp, B; Dulz, B

    2013-05-01

    There is current controversy about the diagnostic overlap between personality disorders and trauma-related disorders. Applying a multicenter study design, trauma-related disorders were investigated via interview assessment in 136 patients with borderline personality disorder (BPD) in 5 specialized treatment centers. Additionally a spectrum of psychological symptoms and prevalence of lifetime traumatic experiences were assessed by questionnaire measures. Diagnostic overlap between BPD and PTSD was found to be high (79%) as well as the overlap of BPD with complex PTSD (55%) and severe dissociative disorders (41%). Including neglect and emotional violence as trauma categories, an extremely high prevalence of lifetime traumatic experiences was reported (96%). Experiences of sexual violence were reported by 48% of all female and 28% of all male patients. Severe forms of physical violence were reported by 65% of all patients. BPD patients with severe psychopathology show a high comorbidity with trauma-related disorders including dissociative disorders. This association has to be taken into account when planning psychological treatment.

  2. Myelin, myelin-related disorders, and psychosis.

    Science.gov (United States)

    Mighdoll, Michelle I; Tao, Ran; Kleinman, Joel E; Hyde, Thomas M

    2015-01-01

    The neuropathological basis of schizophrenia and related psychoses remains elusive despite intensive scientific investigation. Symptoms of psychosis have been reported in a number of conditions where normal myelin development is interrupted. The nature, location, and timing of white matter pathology seem to be key factors in the development of psychosis, especially during the critical adolescent period of association area myelination. Numerous lines of evidence implicate myelin and oligodendrocyte function as critical processes that could affect neuronal connectivity, which has been implicated as a central abnormality in schizophrenia. Phenocopies of schizophrenia with a known pathological basis involving demyelination or dysmyelination may offer insights into the biology of schizophrenia itself. This article reviews the pathological changes in white matter of patients with schizophrenia, as well as demyelinating diseases associated with psychosis. In an attempt to understand the potential role of dysmyelination in schizophrenia, we outline the evidence from a number of both clinically-based and post-mortem studies that provide evidence that OMR genes are genetically associated with increased risk for schizophrenia. To further understand the implication of white matter dysfunction and dysmyelination in schizophrenia, we examine diffusion tensor imaging (DTI), which has shown volumetric and microstructural white matter differences in patients with schizophrenia. While classical clinical-neuropathological correlations have established that disruption in myelination can produce a high fidelity phenocopy of psychosis similar to schizophrenia, the role of dysmyelination in schizophrenia remains controversial.

  3. Validity of the einstein relation in disordered organic semiconductors

    NARCIS (Netherlands)

    Wetzelaer, G.A.H.; Koster, L.J.A.; Blom, P.W.M.

    2011-01-01

    It is controversial whether energetic disorder in semiconductors is already sufficient to violate the classical Einstein relation, even in the case of thermal equilibrium. We demonstrate that the Einstein relation is violated only under nonequilibrium conditions due to deeply trapped carriers, as in

  4. Sleep-related eating disorder in fraternal twins.

    Science.gov (United States)

    De Ocampo, Joel; Foldvary, Nancy; Dinner, Dudley S; Golish, Joseph

    2002-11-01

    Sleep-related eating disorder (SRED) is characterized by nocturnal partial arousals associated with compulsive consumption of food and altered levels of consciousness. Reports of an increased incidence of SRED in relatives of affected individuals suggest a genetic predisposition. We report a woman with SRED whose fraternal twin sister and father are also affected.

  5. Posttraumatic stress disorder among bereaved relatives of cancer patients

    DEFF Research Database (Denmark)

    Elklit, A.; Reinholt, Nina; Nielsen, Louise Hjort

    2010-01-01

    The aim of this study was to assess post-traumatic stress disorder (PTSD) and predictors of PTSD in individuals who experienced the loss of a close relative to cancer. A total of 251 bereaved relatives ages 14 to 76 (M = 41.3, SD = 16.8) were recruited at a counseling service for cancer patients...

  6. Void fraction prediction in saturated flow boiling

    Energy Technology Data Exchange (ETDEWEB)

    Francisco J Collado [Dpto de Ingenieria Mecanica-Motores Termicos, CPS-B, Universidad de Zaragoza, Maria de Luna 50018-Zaragoza (Spain)

    2005-07-01

    Full text of publication follows: An essential element in thermal-hydraulics is the accurate prediction of the vapor void fraction, or fraction of the flow cross-sectional area occupied by steam. Recently, the author has suggested to calculate void fraction working exclusively with thermodynamic properties. It is well known that the usual 'flow' quality, merely a mass flow rate ratio, is not at all a thermodynamic property because its expression in function of thermodynamic properties includes the slip ratio, which is a parameter of the process not a function of state. By the other hand, in the classic and well known expression of the void fraction - in function of the true mass fraction of vapor (also called 'static' quality), and the vapor and liquid densities - does not appear the slip ratio. Of course, this would suggest a direct procedure for calculating the void fraction, provided we had an accurate value of the true mass fraction of vapor, clearly from the heat balance. However the classic heat balance is usually stated in function of the 'flow' quality, what sounds really contradictory because this parameter, as we have noted above, is not at all a thermodynamic property. Then we should check against real data the actual relationship between the thermodynamic properties and the applied heat. For saturated flow boiling just from the inlet of the heated tube, and not having into account the kinetic and potential terms, the uniform applied heat per unit mass of inlet water and per unit length (in short, specific linear heat) should be closely related to a (constant) slope of the mixture enthalpy. In this work, we have checked the relation between the specific linear heat and the thermodynamic enthalpy of the liquid-vapor mixture using the actual mass fraction. This true mass fraction is calculated using the accurate measurements of the outlet void fraction taken during the Cambridge project by Knights and Thom in the sixties for

  7. Statistical geometry of lattice chain polymers with voids of defined shapes: Sampling with strong constraints

    Science.gov (United States)

    Lin, Ming; Chen, Rong; Liang, Jie

    2008-02-01

    Proteins contain many voids, which are unfilled spaces enclosed in the interior. A few of them have shapes compatible to ligands and substrates and are important for protein functions. An important general question is how the need for maintaining functional voids is influenced by, and affects other aspects of proteins structures and properties (e.g., protein folding stability, kinetic accessibility, and evolution selection pressure). In this paper, we examine in detail the effects of maintaining voids of different shapes and sizes using two-dimensional lattice models. We study the propensity for conformations to form a void of specific shape, which is related to the entropic cost of void maintenance. We also study the location that voids of a specific shape and size tend to form, and the influence of compactness on the formation of such voids. As enumeration is infeasible for long chain polymer, a key development in this work is the design of a novel sequential Monte Carlo strategy for generating large number of sample conformations under very constraining restrictions. Our method is validated by comparing results obtained from sampling and from enumeration for short polymer chains. We succeeded in accurate estimation of entropic cost of void maintenance, with and without an increasing number of restrictive conditions, such as loops forming the wall of void with fixed length, with additionally fixed starting position in the sequence. Additionally, we have identified the key structural properties of voids that are important in determining the entropic cost of void formation. We have further developed a parametric model to predict quantitatively void entropy. Our model is highly effective, and these results indicate that voids representing functional sites can be used as an improved model for studying the evolution of protein functions and how protein function relates to protein stability.

  8. Size-Effects in Void Growth

    DEFF Research Database (Denmark)

    Niordson, Christian Frithiof

    2005-01-01

    The size-effect on ductile void growth in metals is investigated. The analysis is based on unit cell models both of arrays of cylindrical voids under plane strain deformation, as well as arrays of spherical voids using an axisymmetric model. A recent finite strain generalization of two higher order...... strain gradient plasticity models is implemented in a finite element program, which is used to study void growth numerically. The results based on the two models are compared. It is shown how gradient effects suppress void growth on the micron scale when compared to predictions based on conventional...... models. This increased resistance to void growth, due to gradient hardening, is accompanied by an increase in the overall strength for the material. Furthermore, for increasing initial void volume fraction, it is shown that the effect of gradients becomes more important to the overall response but less...

  9. The star formation activity in cosmic voids

    CERN Document Server

    Ricciardelli, Elena; Varela, Jesus; Quilis, Vicent

    2014-01-01

    Using a sample of cosmic voids identified in the Sloan Digital Sky Survey Data Release 7, we study the star formation activity of void galaxies. The properties of galaxies living in voids are compared with those of galaxies living in the void shells and with a control sample, representing the general galaxy population. Void galaxies appear to form stars more efficiently than shell galaxies and the control sample. This result can not be interpreted as a consequence of the bias towards low masses in underdense regions, as void galaxy subsamples with the same mass distribution as the control sample also show statistically different specific star formation rates. This highlights the fact that galaxy evolution in voids is slower with respect to the evolution of the general population. Nevertheless, when only the star forming galaxies are considered, we find that the star formation rate is insensitive to the environment, as the main sequence is remarkably constant in the three samples under consideration. This fact...

  10. Familial recurrences of FOXG1-related disorder: Evidence for mosaicism.

    Science.gov (United States)

    McMahon, Kelly Q; Papandreou, Apostolos; Ma, Mandy; Barry, Brenda J; Mirzaa, Ghayda M; Dobyns, William B; Scott, Richard H; Trump, Natalie; Kurian, Manju A; Paciorkowski, Alex R

    2015-12-01

    FOXG1-related disorders are caused by heterozygous mutations in FOXG1 and result in a spectrum of neurodevelopmental phenotypes including postnatal microcephaly, intellectual disability with absent speech, epilepsy, chorea, and corpus callosum abnormalities. The recurrence risk for de novo mutations in FOXG1-related disorders is assumed to be low. Here, we describe three unrelated sets of full siblings with mutations in FOXG1 (c.515_577del63, c.460dupG, and c.572T > G), representing familial recurrence of the disorder. In one family, we have documented maternal somatic mosaicism for the FOXG1 mutation, and all of the families presumably represent parental gonadal (or germline) mosaicism. To our knowledge, mosaicism has not been previously reported in FOXG1-related disorders. Therefore, this report provides evidence that germline mosaicism for FOXG1 mutations is a likely explanation for familial recurrence and should be considered during recurrence risk counseling for families of children with FOXG1-related disorders.

  11. Immune disorders and handedness in dyslexic boys and their relatives.

    Science.gov (United States)

    Jariabková, K; Hugdahl, K; Glós, J

    1995-12-01

    Thirty dyslexic and 30 control boys aged 7-11 years were compared for frequency of immune disorders and handedness as well as for family history of immune disorders and learning disabilities (dyslexia and stuttering). They were also compared for neurological status and for history of speech and language difficulties. There were no significant differences between the two groups in the frequency of immune disorders and in handedness. The results showed significantly more dyslexic boys with soft neurological signs and signs of speech and language disorders. The frequency of dyslexia was significantly higher in the relatives of the dyslexic boys. Also significantly more mothers of the dyslexic boys reported difficulties during pregnancy and complications at delivery. The results are discussed in terms of Geschwind's hypothesis and neuromaturational delay as possible determinants of developmental dyslexia.

  12. Brain responses to disorder-related visual threat in panic disorder.

    Science.gov (United States)

    Feldker, Katharina; Heitmann, Carina Yvonne; Neumeister, Paula; Bruchmann, Maximilian; Vibrans, Laura; Zwitserlood, Pienie; Straube, Thomas

    2016-12-01

    Panic disorder (PD) patients show aberrant neural responses to threatening stimuli in an extended fear network, but results are only partially comparable, and studies implementing disorder-related visual scenes are lacking as stimuli. The neural responses and functional connectivity to a newly developed set of disorder-related, ecologically valid scenes as compared with matched neutral visual scenes, using event-related functional magnetic resonance imaging (fMRI) in 26 PD patients and 26 healthy controls (HC) were investigated. PD patients versus HC showed hyperactivation in an extended fear network comprising brainstem, insula, thalamus, anterior, and mid-cingulate cortex and (dorso-)medial prefrontal cortex for disorder-related versus neutral scenes. Amygdala differences between groups failed significance. Subjective levels of anxiety significantly correlated with brainstem activation in PD patients. Analysis of functional connectivity by means of beta series correlation revealed no emotion-specific alterations in connectivity in PD patients versus HC. The results suggest that subjective anxiety evoked by external stimuli is directly related to altered activation in the homeostatic alarm system in PD. With novel disorder-related stimuli, the study sheds new light on the neural underpinnings of pathological threat processing in PD. Hum Brain Mapp 37:4439-4453, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  13. International Prostatic Symptom Score-voiding/storage subscore ratio in association with total prostatic volume and maximum flow rate is diagnostic of bladder outlet-related lower urinary tract dysfunction in men with lower urinary tract symptoms.

    Directory of Open Access Journals (Sweden)

    Yuan-Hong Jiang

    Full Text Available OBJECTIVES: The aim of this study was to investigate the predictive values of the total International Prostate Symptom Score (IPSS-T and voiding to storage subscore ratio (IPSS-V/S in association with total prostate volume (TPV and maximum urinary flow rate (Qmax in the diagnosis of bladder outlet-related lower urinary tract dysfunction (LUTD in men with lower urinary tract symptoms (LUTS. METHODS: A total of 298 men with LUTS were enrolled. Video-urodynamic studies were used to determine the causes of LUTS. Differences in IPSS-T, IPSS-V/S ratio, TPV and Qmax between patients with bladder outlet-related LUTD and bladder-related LUTD were analyzed. The positive and negative predictive values (PPV and NPV for bladder outlet-related LUTD were calculated using these parameters. RESULTS: Of the 298 men, bladder outlet-related LUTD was diagnosed in 167 (56%. We found that IPSS-V/S ratio was significantly higher among those patients with bladder outlet-related LUTD than patients with bladder-related LUTD (2.28±2.25 vs. 0.90±0.88, p1 or >2 was factored into the equation instead of IPSS-T, PPV were 91.4% and 97.3%, respectively, and NPV were 54.8% and 49.8%, respectively. CONCLUSIONS: Combination of IPSS-T with TPV and Qmax increases the PPV of bladder outlet-related LUTD. Furthermore, including IPSS-V/S>1 or >2 into the equation results in a higher PPV than IPSS-T. IPSS-V/S>1 is a stronger predictor of bladder outlet-related LUTD than IPSS-T.

  14. Constitutive description of casting aluminum alloy based on cylindrical void-cell model

    Institute of Scientific and Technical Information of China (English)

    CHEN Bin; PENG Xiang-he; ZENG Xiang-guo; WU Xin-yan; SUN Shi-tao

    2006-01-01

    Casting aluminum alloys are highly heterogeneous materials with different types of voids that affect the mechanical properties of the material. Through the analysis ora cylindrical void-cell model the evolution equation of the voids was obtained. The evolution equation was embedded into a nonclassical elastoplastic constitutive relation, and an elastoplastic constitutive relation involving void evolution was obtained. A corresponding finite element procedure was developed and applied to the analyses of the distributions of the axial stress and porosity of notched cylindrical specimens of casting aluminum alloy A101. The computed results show good agreement with experimental data.

  15. Gluten-related disorders: certainties, questions and doubts.

    Science.gov (United States)

    Valenti, Simona; Corica, Domenico; Ricciardi, Luisa; Romano, Claudio

    2017-11-01

    In the last decade, the ingestion of gluten, a heterogeneous complex of proteins present in wheat, rice, barley and probably in oats, has been associated with clinical disorders, such as celiac disease, wheat allergy and recently to non-celiac gluten sensitivity or wheat intolerance syndrome. Gluten-related disorders, which are becoming epidemiologically relevant with an estimated global prevalence of about 5%, require the exclusion of gluten from the diet. For the past 5 years, an important shift in the availability of gluten-free products, together with increased consumption in the general population, has been recorded and is estimated to be about 12-25%. Many people follow a self-prescribed gluten-free diet, despite the fact that the majority have not first been previously excluded, or confirmed, as having gluten disorders. They rely on claims that a gluten-free diet improves general health. In this review, we provide an overview of the clinical disorders related to gluten or wheat ingestion, pointing out the current certainties, open questions, possible answers and several doubts in the management of these conditions. KEY MESSAGE Incidence of gluten-related disorders is increased in the last decade and self-diagnosis is frequent with inappropriate starting of a gluten-free diet. Gluten and wheat are considered as the most important triggers to coeliac disease, wheat allergy and non-celiac gluten sensitivity. Pediatricians, allergologist and gastroenterologist are involved in the management of these conditions and appropriate diagnostic protocols are required.

  16. Constraints on Cosmology and Gravity from the Dynamics of Voids

    Science.gov (United States)

    Hamaus, Nico; Pisani, Alice; Sutter, P. M.; Lavaux, Guilhem; Escoffier, Stéphanie; Wandelt, Benjamin D.; Weller, Jochen

    2016-08-01

    The Universe is mostly composed of large and relatively empty domains known as cosmic voids, whereas its matter content is predominantly distributed along their boundaries. The remaining material inside them, either dark or luminous matter, is attracted to these boundaries and causes voids to expand faster and to grow emptier over time. Using the distribution of galaxies centered on voids identified in the Sloan Digital Sky Survey and adopting minimal assumptions on the statistical motion of these galaxies, we constrain the average matter content Ωm=0.281 ±0.031 in the Universe today, as well as the linear growth rate of structure f /b =0.417 ±0.089 at median redshift z ¯=0.57 , where b is the galaxy bias (68% C.L.). These values originate from a percent-level measurement of the anisotropic distortion in the void-galaxy cross-correlation function, ɛ =1.003 ±0.012 , and are robust to consistency tests with bootstraps of the data and simulated mock catalogs within an additional systematic uncertainty of half that size. They surpass (and are complementary to) existing constraints by unlocking cosmological information on smaller scales through an accurate model of nonlinear clustering and dynamics in void environments. As such, our analysis furnishes a powerful probe of deviations from Einstein's general relativity in the low-density regime which has largely remained untested so far. We find no evidence for such deviations in the data at hand.

  17. Omega-3 fatty acids in ADHD and related neurodevelopmental disorders.

    Science.gov (United States)

    Richardson, Alexandra J

    2006-04-01

    Omega-3 fatty acids are dietary essentials, and are critical to brain development and function. Increasing evidence suggests that a relative lack of omega-3 may contribute to many psychiatric and neurodevelopmental disorders. This review focuses on the possible role of omega-3 in attention-deficit/hyperactivity disorder (ADHD) and related childhood developmental disorders, evaluating the existing evidence from both research and clinical perspectives. Theory and experimental evidence support a role for omega-3 in ADHD, dyslexia, developmental coordination disorder (DCD) and autism. Results from controlled treatment trials are mixed, but the few studies in this area have involved different populations and treatment formulations. Dietary supplementation with fish oils (providing EPA and DHA) appears to alleviate ADHD-related symptoms in at least some children, and one study of DCD children also found benefits for academic achievement. Larger trials are now needed to confirm these findings, and to establish the specificity and durability of any treatment effects as well as optimal formulations and dosages. Omega-3 is not supported by current evidence as a primary treatment for ADHD or related conditions, but further research in this area is clearly warranted. Given their relative safety and general health benefits, omega-3 fatty acids offer a promising complementary approach to standard treatments.

  18. Coeliac disease and gluten-related disorders in childhood.

    Science.gov (United States)

    Vriezinga, Sabine L; Schweizer, Joachim J; Koning, Frits; Mearin, M Luisa

    2015-09-01

    Gluten-related disorders such as coeliac disease, wheat allergy and noncoeliac gluten sensitivity are increasingly being diagnosed in children. Coeliac disease occurs frequently, affecting 1-3% of the Western population. The condition manifests at a very young age, more so in girls, and is related to the HLA genotype. Coeliac disease might be considered a public health problem and, as primary prevention is not possible, the debate on mass screening should be reopened. Wheat proteins, including gluten, are responsible for one of the most common food allergies in children: wheat allergy. Unlike coeliac disease and wheat allergy, noncoeliac gluten sensitivity is an unclear and controversial entity. These three gluten-related disorders are treated with a gluten-free diet. In coeliac disease, the diet should be strictly followed, whereas wheat allergy only requires wheat elimination and in noncoeliac gluten sensitivity occasional trials of gluten reintroduction can be done. A good diagnostic work-up is important for gluten-related disorders in childhood to avoid unnecessary restrictive diets in children. In this Review, we provide an overview of the pathogenesis, diagnosis and management of the most common gluten-related disorders in children.

  19. Online biomedical resources for malaria-related red cell disorders.

    Science.gov (United States)

    Piel, Frédéric B; Howes, Rosalind E; Nyangiri, Oscar A; Moyes, Catherine L; Williams, Thomas N; Weatherall, David J; Hay, Simon I

    2013-07-01

    Warnings about the expected increase of the global public health burden of malaria-related red cell disorders are accruing. Past and present epidemiological data are necessary to track spatial and temporal changes in the frequencies of these genetic disorders. A number of open access biomedical databases including data on malaria-related red cell disorders have been launched over the last two decades. Here, we review the content of these databases, most of which focus on genetic diversity, and we describe a new epidemiological resource developed by the Malaria Atlas Project. To tackle upcoming public health challenges, the integration of epidemiological and genetic data is important. As many countries are considering implementing national screening programs, strategies to make such data more accessible are also needed.

  20. Paraphilia-related disorders and personality disorders in sexual homicide perpetrators

    Directory of Open Access Journals (Sweden)

    Martin P. Kafka

    2010-06-01

    Full Text Available We investigated the relationship between paraphilias (PA, paraphilia-related disorders (PRD, and personality disorders retrospectively in a sample of 161 sexual murderers. Four groups were compared: (1 sexual murderers without a PA or a PRD diagnosis (n=47, (2 sexual murderers with at least one PRD but no PA (n=29, (3 murderers with at least one PA but no PRDs (n=29, and finally, (4 those with a combination of both (PA + PRD, n=56. The PA + PRD group showed a significantly higher prevalence for antisocial (42.9% and sadistic (32.1% personality disorders compared to the three other groups. Schizoid personality disorder was more often diagnosed in the two paraphilic diagnosed subgroups (PA = 24.1%; PA + PRD = 24.9%. Our data suggests that PRDs and personality disorders should be systematically assessed in sexual offenders, and that the combination of PAs and PRDs in sexual offenders may characterize a group who are more impulsive, consistent with personality disorders such as antisocial personality disorder.

  1. Large-scale clustering of cosmic voids

    Science.gov (United States)

    Chan, Kwan Chuen; Hamaus, Nico; Desjacques, Vincent

    2014-11-01

    We study the clustering of voids using N -body simulations and simple theoretical models. The excursion-set formalism describes fairly well the abundance of voids identified with the watershed algorithm, although the void formation threshold required is quite different from the spherical collapse value. The void cross bias bc is measured and its large-scale value is found to be consistent with the peak background split results. A simple fitting formula for bc is found. We model the void auto-power spectrum taking into account the void biasing and exclusion effect. A good fit to the simulation data is obtained for voids with radii ≳30 Mpc h-1 , especially when the void biasing model is extended to 1-loop order. However, the best-fit bias parameters do not agree well with the peak-background results. Being able to fit the void auto-power spectrum is particularly important not only because it is the direct observable in galaxy surveys, but also our method enables us to treat the bias parameters as nuisance parameters, which are sensitive to the techniques used to identify voids.

  2. Constitutive modeling of rate dependence and microinertia effects in porous-plastic materials with multi-sized voids (MSVs)

    Science.gov (United States)

    Liu, J. X.; El Sayed, T.

    2013-01-01

    Micro-voids of varying sizes exist in most metals and alloys. Both experiments and numerical studies have demonstrated the critical influence of initial void sizes on void growth. The classical Gurson-Tvergaard-Needleman model summarizes the influence of voids with a single parameter, namely the void-volume fraction, excluding any possible effects of the void-size distribution. We extend our newly proposed model including the multi-sized void (MSV) effect and the void-interaction effect for the capability of working for both moderate and high loading rate cases, where either rate dependence or microinertia becomes considerable or even dominant. Parametric studies show that the MSV-related competitive mechanism among void growth leads to the dependence of the void growth rate on void size, which directly influences the void's contribution to the total energy composition. We finally show that the stress-strain constitutive behavior is also affected by this MSV-related competitive mechanism. The stabilizing effect due to rate sensitivity and microinertia is emphasized.

  3. Obsessive-compulsive disorder and its related disorders: a reappraisal of obsessive-compulsive spectrum concepts

    Science.gov (United States)

    Murphy, Dennis L.; Timpano, Kiara R.; Wheaton, Michael G.; Greenberg, Benjamin D.; Miguel, Euripedes C.

    2010-01-01

    Obsessive-compulsive disorder (OCD) is a clinical syndrome whose hallmarks are excessive, anxiety-evoking thoughts and compulsive behaviors that are generally recognized as unreasonable, but which cause significant distress and impairment. When these are the exclusive symptoms, they constitute uncomplicated OCD. OCD may also occur in the context of other neuropsychiatric disorders, most commonly other anxiety and mood disorders. The question remains as to whether these combinations of disorders should be regarded as independent, cooccurring disorders or as different manifestations of an incompletely understood constellation of OCD spectrum disorders with a common etiology. Additional considerations are given here to two potential etiology-based subgroups: (i) an environmentally based group in which OCD occurs following apparent causal events such as streptococcal infections, brain injury, or atypical neuroleptic treatment; and (ii) a genomically based group in which OCD is related to chromosomal anomalies or specific genes. Considering the status of current research, the concept of OCD and OCD-related spectrum conditions seems fluid in 2010, and in need of ongoing reappraisal. PMID:20623919

  4. Hepatitis C virus-related lymphoproliferative disorders: An overview

    Institute of Scientific and Technical Information of China (English)

    Anna Linda Zignego; Carlo Giannini; Clodoveo Ferri

    2007-01-01

    Hepatitis C virus (HCV) is a global health problem affecting 3% of the world's population (about 180 million) and a cause of both hepatic and extrahepatic diseases. B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia, represent the most closely related as well as the most investigated HCV-related extrahepatic disorder. The association between extrahepatic (lymphoma) as well as hepatic malignancies (hepatocellular carcinoma) has justified the inclusion of HCV among human cancer viruses. HCV-associated manifestations also include porphyria cutanea tarda,lichen planus, nephropathies, thyreopathies, sicca syndrome, idiopathic pulmonary fibrosis, diabetes,chronic polyarthritis, sexual dysfunctions, cardiopathy/atherosclerosis, and psychopathological disorders.A pathogenetic link between HCV virus and some lymphoproliferative disorders was confirmed by their responsiveness to antiviral therapy, which is now considered the first choice treatment. The aim of the present paper is to provide an overview of extrahepatic manifestations of HCV infection with particular attention to B-cell lymphoproliferative disorders. Available pathogenetic hypotheses and suggestions about the most appropriate, currently available, therapeutic approaches will also be discussed.

  5. Geometric and Chemical Composition Effects on Healing Kinetics of Voids in Mg-bearing Al Alloys

    Science.gov (United States)

    Song, Miao; Du, Kui; Wang, Chunyang; Wen, Shengping; Huang, Hui; Nie, Zuoren; Ye, Hengqiang

    2016-05-01

    The healing kinetics of nanometer-scale voids in Al-Mg-Er and Al-Mg-Zn-Er alloy systems were investigated with a combination of in situ transmission electron microscopy and electron tomography at different temperatures. Mg was observed completely healing the voids, which were then rejuvenated to the alloy composition with further aging, in the Al-Mg-Er alloy. On the contrary, Mg51Zn20 intermetallic compound was formed in voids in the Al-Mg-Zn-Er alloy, which leads to complete filling of the voids but not rejuvenation for the material. For voids with different geometrical aspects, different evolution processes were observed, which are related to the competition between bulk and surface diffusion of the alloys. For voids with a large size difference in their two ends, a viscous flow of surface atoms can be directly observed with in situ electron microscopy, when the size of one end becomes less than tens of nanometers.

  6. Work-related musculoskeletal disorders : back to work report

    NARCIS (Netherlands)

    Pinder, A.; Yeomans, L.; Heuvel, S. van den; Blatter, B.; Verjans, M.; Muylaert, K.; Broeck, V.de; Buffet, M.A.; Nevala, N.

    2007-01-01

    Work-related musculoskeletal disorders (MSDs) are impairments of bodily structures, such as muscles, joints, tendons, ligaments, nerves or the localised blood circulation system. MSDs can interfere with activities at work, and can cause an increase in sickness absence, and chronic occupational

  7. Disaster-related posttraumatic stress disorder and physical health

    NARCIS (Netherlands)

    Dirkzwager, J.E.; van der Velden, P.G.; Grievink, Linda; Yzermans, C.J.

    2007-01-01

    Objective: To examine the relationship between posttraumatic stress disorder (PTSD) and self-reported as well as physicianrecorded physical health in a sample of survivors (n 896) of a man-made disaster, using a longitudinal design that included predisaster health data. Most studies on the relations

  8. Zolpidem-induced sleep-related eating disorder.

    Science.gov (United States)

    Yun, Chang-Ho; Ji, Ki-Hwan

    2010-01-15

    An association between zolpidem administration and sleep-related eating disorder (SRED) has been suggested. The authors observed zolpidem-induced SRED in restless legs syndrome (RLS). With the review of previous reports, we identified a common occurrence of RLS in zolpidem-induced SRED.

  9. Vertebro-basilar Ischemia and Sleep Related Breathing Disorders (Abstract)

    Institute of Scientific and Technical Information of China (English)

    You Guoxiong; Yang Hongjun; Zhu Shixiu; Zhang Kejing

    2000-01-01

    @@Introduction The relationship between cerebrovascular diseases (CVD) and sleep-related breathing disorders (SRBD) has attracted people's attention more and more in the past years. However,the subtentorial ischemic attacks - vertibrobasilar ischemia (VBI) has not been reported yet. This study is to show the interaction between VBI and SRBD.

  10. Posttraumatic stress disorder's dysphoria dimension and relations with generalized anxiety disorder symptoms.

    Science.gov (United States)

    Durham, Tory A; Elhai, Jon D; Fine, Thomas H; Tamburrino, Marijo; Cohen, Gregory; Shirley, Edwin; Chan, Philip K; Liberzon, Israel; Galea, Sandro; Calabrese, Joseph R

    2015-07-30

    The present study investigated symptom relations between two highly comorbid disorders--posttraumatic stress disorder (PTSD) and generalized anxiety disorder (GAD)--by exploring their underlying dimensions. Based on theory and prior empirical research it was expected that the dysphoria factor of PTSD would be more highly related to GAD. As part of a longitudinal project of mental health among Ohio National Guard Soldiers, 1266 subjects were administered the Posttraumatic Stress Disorder Checklist (PCL) and Generalized Anxiety Disorder-7 scale (GAD-7). Confirmatory factor analyses (CFAs) were conducted to examine two models of PTSD and to determine which PTSD factors were more related to the GAD factor. The results indicate that the GAD factor was significantly more highly correlated with PTSD's dysphoria factor than with all other PTSD factors, including PTSD's reexperiencing factor, avoidance factor, and hyperarousal factor. Results indicate GAD was not significantly more highly correlated with numbing than most other factors of PTSD. The results are consistent with prior research. Implications of the results are discussed in regards to PTSD in DSM-5, comorbidity and diagnostic specificity.

  11. Quality of Smartphone Apps Related to Panic Disorder

    OpenAIRE

    Van Singer, Mathias; Chatton, Anne; Khazaal, Yasser

    2015-01-01

    Quality of smartphone apps related to panic: smartphone apps have a growing role in health care. This study assessed the quality of English-language apps for panic disorder (PD) and compared paid and free apps. Keywords related to PD were entered into the Google Play Store search engine. Apps were assessed using the following quality indicators: accountability, interactivity, self-help score (the potential of smartphone apps to help users in daily life), and evidence-based content quality. Th...

  12. [Socioeconomic aspects of sleep-related breathing disorders].

    Science.gov (United States)

    Sonka, K; Vyskocilová, J

    2002-01-01

    Sleep related breathing disorders (especially sleep apnea syndrome--SAS) limit the patient through deteriorated nocturnal sleep, insufficient wakefulness, daytime inefficiency and tiredness including a cognitive impairment, through higher rate of road accidents, higher co morbidity, through impaired quality of life and higher mortality. The society pays for the SAS patient higher medical costs and other expenses related to the accidents, co morbidity and lower professional productivity.

  13. Universal density profile for cosmic voids.

    Science.gov (United States)

    Hamaus, Nico; Sutter, P M; Wandelt, Benjamin D

    2014-06-27

    We present a simple empirical function for the average density profile of cosmic voids, identified via the watershed technique in ΛCDM N-body simulations. This function is universal across void size and redshift, accurately describing a large radial range of scales around void centers with only two free parameters. In analogy to halo density profiles, these parameters describe the scale radius and the central density of voids. While we initially start with a more general four-parameter model, we find two of its parameters to be redundant, as they follow linear trends with the scale radius in two distinct regimes of the void sample, separated by its compensation scale. Assuming linear theory, we derive an analytic formula for the velocity profile of voids and find an excellent agreement with the numerical data as well. In our companion paper [Sutter et al., arXiv:1309.5087 [Mon. Not. R. Astron. Soc. (to be published)

  14. Air void structure and frost resistance

    DEFF Research Database (Denmark)

    Hasholt, Marianne Tange

    2014-01-01

    is proportional to the product of total air content and specific surface. In all 4 cases, the conclusion is concurrent that the parameter of total surface area of air voids performs equally well or better than the spacing factor when linking air void characteristics to frost resistance (salt frost scaling...... will take place in the air void, being feed from the capillary, but without pressure build-up in the capillary. If the capillary is not connected to an air void, ice formation will take place in the capillary pore, where it can generate substantial pressure. Like this, frost resistance depends......This article compiles results from 4 independent laboratory studies. In each study, the same type of concrete is tested at least 10 times, the air void structure being the only variable. For each concrete mix both air void analysis of the hardened concrete and a salt frost scaling test...

  15. Void Profile from Planck Lensing Potential Map

    Science.gov (United States)

    Chantavat, Teeraparb; Sawangwit, Utane; Wandelt, Benjamin D.

    2017-02-01

    We use the lensing potential map from Planck CMB lensing reconstruction analysis and the “Public Cosmic Void Catalog” to measure the stacked void lensing potential. We have made an attempt to fit the HSW void profile parameters from the stacked lensing potential. In this profile, four parameters are needed to describe the shape of voids with different characteristic radii R V . However, we have found that after reducing the background noise by subtracting the average background, there is a residue lensing power left in the data. The inclusion of the environment shifting parameter, {γ }V, is necessary to get a better fit to the data with the residue lensing power. We divide the voids into two redshift bins: cmass1 (0.45Digital Sky Survey voids reside in an underdense region.

  16. Animal Models of Hemophilia and Related Bleeding Disorders

    Science.gov (United States)

    Lozier, Jay N.; Nichols, Timothy C.

    2013-01-01

    Animal models of hemophilia and related diseases are important for development of novel treatments and to understand the pathophysiology of bleeding disorders in humans. Testing in animals with the equivalent human disorder provides informed estimates of doses and measures of efficacy, which aids in design of human trials. Many models of hemophilia A, hemophilia B, and von Willebrand disease have been developed from animals with spontaneous mutations (hemophilia A dogs, rats, sheep; hemophilia B dogs; and von Willebrand disease pigs and dogs), or by targeted gene disruption in mice to create hemophilia A, B, or VWD models. Animal models have been used to generate new insights into the pathophysiology of each bleeding disorder and also to perform pre-clinical assessments of standard protein replacement therapies as well as novel gene transfer technology. Both the differences between species and differences in underlying causative mutations must be considered in choosing the best animal for a specific scientific study PMID:23956467

  17. [Neurolinguistic aspects in autism spectrum disorders. Neuroanatomical and functional relations].

    Science.gov (United States)

    Palau-Baduell, M; Valls-Santasusana, A; Salvadó-Salvadó, B

    2010-03-03

    Impairments in language and communication are a defining feature of autism spectrum disorders. There is significant variability in linguistic abilities in autism spectrum disorders. They have difficulties with certain aspects of language such as semantics functions, syntax, prosody and phonology, although the most evident language deficits concern to pragmatics functioning. These language difficulties can cause serious problems in social interaction. The neural bases underlying this failure to develop language are unknown. Several functional and structural imaging studies have identified irregularities in language-related regions in autism spectrum disorders, such as morphometric differences in Broca's area and Wernicke's area, and patterns of reduced or reversed laterality in frontal and temporal cortex. There is also decreased functional connectivity between anterior and posterior language regions.

  18. Personality disorder symptoms are differentially related to divorce frequency.

    Science.gov (United States)

    Disney, Krystle L; Weinstein, Yana; Oltmanns, Thomas F

    2012-12-01

    Divorce is associated with a multitude of outcomes related to health and well-being. Data from a representative community sample (N = 1,241) of St. Louis residents (ages 55-64) were used to examine associations between personality pathology and divorce in late midlife. Symptoms of the 10 DSM-IV personality disorders were assessed with the Structured Interview for DSM-IV Personality and the Multisource Assessment of Personality Pathology (both self and informant versions). Multiple regression analyses showed Paranoid and Histrionic personality disorder symptoms to be consistently and positively associated with number of divorces across all three sources of personality assessment. Conversely, Avoidant personality disorder symptoms were negatively associated with number of divorces. The present paper provides new information about the relationship between divorce and personality pathology at a developmental stage that is understudied in both domains.

  19. Internet gaming disorder, social network disorder and laterality: handedness relates to pathological use of social networks.

    Science.gov (United States)

    Bouna-Pyrrou, Polyxeni; Mühle, Christiane; Kornhuber, Johannes; Lenz, Bernd

    2015-08-01

    The internet age bears new challenges that include health risks. It is agreed that excessive internet use may reach pathological levels. However, the concept of internet addiction lacks specificity and, therefore, warrants studies on its diagnostic and etiologic classification. This study was conducted to characterize the novel DSM-5 criteria for internet gaming disorder and the adapted criteria for the "social network disorder". Based on the established association of handedness and substance use disorders, we also explored whether internet use related to laterality. For this study, 3,287 volunteers participated in the online survey and gave particulars concerning their internet use in general, internet gaming and use of social networks, laterality markers (hand, foot, eye, ear, rotational preference in gymnastics, and head turning asymmetry) and health status. Of the participants, 1.1 % fulfilled the criteria for internet gaming disorder, and 1.8 % fulfilled the criteria for social network disorder. The applied criteria were highly correlated with the time spent on the respective internet activities (p internet for the classification as pathological (p internet gaming and social network use and provide evidence that biological markers of substance use disorders are involved in internet addiction.

  20. Gender-related features of persistent delusional disorders.

    Science.gov (United States)

    Wustmann, Tobias; Pillmann, Frank; Marneros, Andreas

    2011-02-01

    This paper presents gender-related features of Delusional Disorder. It is part of the Halle Delusional Syndromes Study (HADES-Study). All inpatients fulfilling the DSM-IV/ICD-10 criteria of Delusional Disorder/Persistent Delusional Disorder (DD) during a 14-year period were included and followed up for an average of 10.8 years. Gender distribution was almost equal, women became ill significantly later than men, and almost all women had a stable diagnosis-in contrast to men. The great majority of women, at the end of the follow-up period, had an unremitted DD. Women more frequently had low social functioning at admission, but then were more compliant and received more frequently pharmacological medication. There were no differences in the delusional topic and no differences regarding long-term disability and autarky. In spite of previous reports, the HADES-Study found no gender difference in the frequency of DD. However, men tended more frequently to change into schizophrenia and schizoaffective disorder. In these cases, the DD might have been a prodrome of schizophrenia or schizoaffective disorder, which manifests later in life. Although in both female and male DD patients, the majority remained unremitted, almost none of them lost their autarky (independent living). While women more frequently received psychopharmacological medication, their DD was usually found to be unremitted.

  1. Factors Related to Social Support in Neurological and Mental Disorders.

    Science.gov (United States)

    Kamenov, Kaloyan; Cabello, Maria; Caballero, Francisco Félix; Cieza, Alarcos; Sabariego, Carla; Raggi, Alberto; Anczewska, Marta; Pitkänen, Tuuli; Ayuso-Mateos, Jose Luis

    2016-01-01

    Despite the huge body of research on social support, literature has been primarily focused on its beneficial role for both physical and mental health. It is still unclear why people with mental and neurological disorders experience low levels of social support. The main objective of this study was to explore what are the strongest factors related to social support and how do they interact with each other in neuropsychiatric disorders. The study used cross-sectional data from 722 persons suffering from dementia, depression, epilepsy, migraine, multiple sclerosis, Parkinson's disease, schizophrenia, stroke, and substance use disorders. Multiple linear regressions showed that disability was the strongest factor for social support. Extraversion and agreeableness were significant personality variables, but when the interaction terms between personality traits and disability were included, disability remained the only significant variable. Moreover, level of disability mediated the relationship between personality (extraversion and agreeableness) and level of social support. Moderation analysis revealed that people that had mental disorders experienced lower levels of support when being highly disabled compared to people with neurological disorders. Unlike previous literature, focused on increasing social support as the origin of improving disability, this study suggested that interventions improving day-to-day functioning or maladaptive personality styles might also have an effect on the way people perceive social support. Future longitudinal research, however, is warranted to explore causality.

  2. Factors Related to Social Support in Neurological and Mental Disorders.

    Directory of Open Access Journals (Sweden)

    Kaloyan Kamenov

    Full Text Available Despite the huge body of research on social support, literature has been primarily focused on its beneficial role for both physical and mental health. It is still unclear why people with mental and neurological disorders experience low levels of social support. The main objective of this study was to explore what are the strongest factors related to social support and how do they interact with each other in neuropsychiatric disorders. The study used cross-sectional data from 722 persons suffering from dementia, depression, epilepsy, migraine, multiple sclerosis, Parkinson's disease, schizophrenia, stroke, and substance use disorders. Multiple linear regressions showed that disability was the strongest factor for social support. Extraversion and agreeableness were significant personality variables, but when the interaction terms between personality traits and disability were included, disability remained the only significant variable. Moreover, level of disability mediated the relationship between personality (extraversion and agreeableness and level of social support. Moderation analysis revealed that people that had mental disorders experienced lower levels of support when being highly disabled compared to people with neurological disorders. Unlike previous literature, focused on increasing social support as the origin of improving disability, this study suggested that interventions improving day-to-day functioning or maladaptive personality styles might also have an effect on the way people perceive social support. Future longitudinal research, however, is warranted to explore causality.

  3. Prevalence of work-related musculoskeletal disorders among physical therapists

    Directory of Open Access Journals (Sweden)

    Zaheen Iqbal

    2015-08-01

    Full Text Available Background: Health professions like dentistry, nursing and physical therapy have been reported at high risk for developing workrelated musculoskeletal disorders. Results of studies conducted in these occupational groups may help formulate prevention strategies. However, no such data among physical therapists has been reported in India. Material and Methods: We conducted an online survey among 100 physiotherapists in Delhi. Results: The response rate was 75%. The prevalence of work-related musculoskeletal disorders is found to be high since 92% of them reported to feel some pain after joining physical therapy which affects daily activities and even sometimes forces them to change their work. Physical therapists specialty, gender, furniture used in clinic and duration of patient contact are found to be related to the pain development (p < 0.05. Conclusions: We need to emphasize the role of ergonomics and techniques of patient handling in development of work-related pain symptoms. Med Pr 2015;66(4:459–469

  4. [The amygdala and its relation to autism, behavioural disorders and other neurodevelopmental disorders].

    Science.gov (United States)

    Ruggieri, Víctor L

    2014-02-24

    The amygdala is related with the recognition of the emotional meaning of stimuli, long-term memory, the orientation of social stimuli and the perception of gaze orientation. It plays a fundamental role in the recognition of faces, especially those expressing fear, and makes it possible to comprehend different emotional states, which will facilitate an appropriate social cognition. Dysfunctions of the amygdala have been associated to a number of different neurodevelopmental disorders as well as neurocognitive and behavioural disorders in specific neurogenetic entities. A number of studies focused on the amygdalic complex have allowed researchers to understand many pathophysiological aspects and to formulate new hypotheses regarding their origins. Given that the disorders or conditions in which the role of the amygdala has been evoked are becoming increasingly more extensive, this article refers the reader to those that have aroused the most interest in recent years. Thus, they can be divided into two groups: developmental and behavioural disorders (autism, anxiety disorders, bipolar disorder, alexithymia and anorexia nervosa) and specific neurogenetic entities (fragile X, Rett, Prader-Willi and Williams syndromes), in which structural or dysfunctional alterations have been observed that may be related with their neurocognitive and behavioural symptoms. It is important to remember that the amygdala is a highly connected structure that forms truly functional networks and has been associated to different disorders with varied explanations and includes several different pathophysiological phenomena. Its role must not, therefore, be simplified in a reductionistic manner, but also placed upon a hierarchy of dysfunctions in other areas that interact with it.

  5. Clinical and diagnostic aspects of gluten related disorders.

    Science.gov (United States)

    Tovoli, Francesco; Masi, Chiara; Guidetti, Elena; Negrini, Giulia; Paterini, Paola; Bolondi, Luigi

    2015-03-16

    Gluten is one of the most abundant and widely distributed components of food in many areas. It can be included in wheat, barley, rye, and grains such as oats, barley, spelt, kamut, and triticale. Gluten-containing grains are widely consumed; in particular, wheat is one of the world's primary sources of food, providing up to 50% of the caloric intake in both industrialized and developing countries. Until two decades ago, celiac disease (CD) and other gluten-related disorders were believed to be exceedingly rare outside of Europe and were relatively ignored by health professionals and the global media. In recent years, however, the discovery of important diagnostic and pathogenic milestones led CD from obscurity to global prominence. In addition, interestingly, people feeding themselves with gluten-free products greatly outnumber patients affected by CD, fuelling a global consumption of gluten-free foods with approximately $2.5 billion in United States sales each year. The acknowledgment of other medical conditions related to gluten that has arisen as health problems, providing a wide spectrum of gluten-related disorders. In February 2011, a new nomenclature for gluten-related disorders was created at a consensus conference in London. In this review, we analyse innovations in the field of research that emerged after the creation of the new classification, with particular attention to the new European Society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines for CD and the most recent research about non-celiac gluten sensitivity.

  6. Trauma-related obsessive-compulsive disorder: a review.

    Science.gov (United States)

    Dykshoorn, Kristy L

    2014-01-01

    Obsessive-compulsive disorder (OCD) is a highly researched and conceptualized disorder, and yet it remains one of the most debilitating, widespread, and expensive disorders one can be afflicted with [Real, E., Labad, J., Alonso, P., Segalas, C., Jimenez-Murcia, S., Bueno, B., … Menchon, J. M. (2011). Stressful life events at onset of obsessive-compulsive disorder are associated with a distinct clinical pattern. Depression and Anxiety, 28, 367-376. doi:10.1002/da.20792]. Exposure treatments and cognitive-behavioural therapy (CBT) have been largely accepted as best practice for those with OCD, and yet there are still many who are left with "treatment-resistant OCD" [Rowa, K., Antony, M., & Swinson, R. (2007). Exposure and response prevention. In C. Purdon, M. Antony, & L. J. Summerfeldt (Eds.), Psychological treatment of obsessive-compulsive disorder: Fundamentals and beyond (pp. 79-109). Washington, DC: American Psychological Association; Foa, E. B. (2010). Cognitive behavioural therapy of obsessive-compulsive disorder. Dialogues of Clinical Neuroscience, 12, 199-207]. Similarly, exposure treatments and CBT have been accepted as best practice for trauma-related distress (i.e. post-traumatic stress disorder; Foa, E. B., Keane, T. M., Friedman, M. J., & Cohen, J. A. (2009). Effective treatments for PTSD: Practice guidelines from the international society for traumatic studies (2nd ed.). New York, NY: The Guilford Press). From a literature review, evidence has been provided that demonstrates a high prevalence rate (30-82%) of OCD among individuals with a traumatic history in comparison to the prevalence rate of the general population (1.1-1.8%; [Cromer, K. R., Schmidt, N. B., & Murphy, D. L. (2006). An investigation of traumatic life events and obsessive-compulsive disorder. Behaviour Research and Therapy, 45, 1683-1691. doi:10.1016/j.brat.2006.08.018; Fontenelle, L. F., Cocchi, L., Harrison, B. J., Shavitt, R. G., do Rosario, M. C., Ferrao, Y. A

  7. Size effects on void growth in single crystals with distributed voids

    DEFF Research Database (Denmark)

    Borg, Ulrik; Niordson, Christian Frithiof; Kysar, J.W.

    2008-01-01

    The effect of void size on void growth in single crystals with uniformly distributed cylindrical voids is studied numerically using a finite deformation strain gradient crystal plasticity theory with an intrinsic length parameter. A plane strain cell model is analyzed for a single crystal...

  8. The darkness that shaped the void: dark energy and cosmic voids

    NARCIS (Netherlands)

    Bos, E. G. Patrick; van de Weygaert, Rien; Dolag, Klaus; Pettorino, Valeria

    2012-01-01

    We assess the sensitivity of void shapes to the nature of dark energy that was pointed out in recent studies and also investigate whether or not void shapes are useable as an observational probe in galaxy redshift surveys. Our focus is on the evolution of the mean void ellipticity and its underlying

  9. The darkness that shaped the void : Dark energy and cosmic voids

    NARCIS (Netherlands)

    Bos, E. G. Patrick; van de Weygaert, Rien; Dolag, Klaus; Pettorino, Valeria

    2012-01-01

    We assess the sensitivity of void shapes to the nature of dark energy that was pointed out in recent studies and also investigate whether or not void shapes are useable as an observational probe in galaxy redshift surveys. Our focus is on the evolution of the mean void ellipticity and its underlying

  10. Personality Disorder Symptoms Are Differentially Related to Divorce Frequency

    OpenAIRE

    Disney, Krystle L.; Weinstein, Yana; OLTMANNS, THOMAS F.

    2012-01-01

    Divorce is associated with a multitude of outcomes related to health and well-being. Data from a representative community sample (N = 1,241) of St. Louis residents (ages 55–64) were used to examine associations between personality pathology and divorce in late midlife. Symptoms of the 10 DSM–IV personality disorders were assessed with the Structured Interview for DSM–IV Personality and the Multisource Assessment of Personality Pathology (both self and informant versions). Multiple regression ...

  11. Epidemiological aspects of studying work-related musculoskeletal disorders.

    Science.gov (United States)

    Driscoll, Tim

    2011-02-01

    There are many challenges to conducting valid epidemiological research of work-related musculoskeletal disorders and interpreting reports describing the results. In particular, these concern the basic study design, selection of subjects, measurement of exposure and outcome, control of confounding and the limitations of workers' compensation data systems. Researchers and people interested in the research results need to be aware of the major potential problems and pay careful attention to them when designing, conducting and using the results of such research.

  12. Personality Disorder Symptoms Are Differentially Related to Divorce Frequency

    OpenAIRE

    Disney, Krystle L.; Weinstein, Yana; Oltmanns, Thomas F.

    2012-01-01

    Divorce is associated with a multitude of outcomes related to health and well-being. Data from a representative community sample (N = 1,241) of St. Louis residents (ages 55–64) were used to examine associations between personality pathology and divorce in late midlife. Symptoms of the 10 DSM–IV personality disorders were assessed with the Structured Interview for DSM–IV Personality and the Multisource Assessment of Personality Pathology (both self and informant versions). Multiple regression ...

  13. Wheat-related disorders reviewed: making a grain of sense.

    Science.gov (United States)

    Marchioni Beery, Renée M; Birk, John W

    2015-06-01

    Wheat-related disorders have become a growing area of clinical and scientific interest and can be categorized broadly as: autoimmune-mediated; allergic; and non-autoimmune/non-allergic conditions. Non-celiac gluten sensitivity (NCGS) and non-celiac wheat sensitivity (NCWS) present on this spectrum as disorders associated with adverse gastrointestinal and extra-intestinal manifestations following exposure to gluten and/or other wheat-related constituents. NCGS/NCWS is increasingly considered in patients with unexplained symptoms after the exclusions of celiac disease and wheat allergy. As objective diagnostic data and specific biomarkers are lacking, response to a gluten-free/wheat-free diet can confirm the presence of NCGS/NCWS. An association with irritable bowel syndrome has been detected, and the effects of other food components, such as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols, may contribute. Our organization and synthesis of extant knowledge pertaining to wheat-related disorders may advance current practice and research efforts toward an improved understanding of NCGS/NCWS as an evolving clinical entity.

  14. A new geometrical approach to void statistics

    CERN Document Server

    Werner, M C

    2014-01-01

    Modelling cosmic voids as spheres in Euclidean space, the notion of a de-Sitter configuration space is introduced. It is shown that a uniform distribution over this configuration space yields a power-law approximating the void size distribution in an intermediate range of volumes, as well as an estimate for the fractal dimension of the large scale structure.

  15. Tracing the gravitational potential using cosmic voids

    CERN Document Server

    Nadathur, Seshadri; Crittenden, Robert

    2016-01-01

    The properties of large underdensities in the distribution of galaxies in the Universe, known as cosmic voids, are potentially sensitive probes of fundamental physics. We use data from the MultiDark suite of N-body simulations and multiple halo occupation distribution mocks to study the relationship between galaxy voids and the gravitational potential $\\Phi$. We find that the majority of galaxy voids correspond to local density minima in larger-scale overdensities, and thus lie in potential wells. However, a subset of voids can be identified that closely trace maxima of the gravitational potential and thus stationary points of the velocity field. We identify a new void observable, $\\lambda_v$, which depends on a combination of the void size and the average galaxy density contrast within the void, and show that it provides a good proxy indicator of the potential at the void location. A simple linear scaling of $\\Phi$ as a function of $\\lambda_v$ is found to hold, independent of the redshift and properties of t...

  16. Simulation of dust voids in complex plasmas

    NARCIS (Netherlands)

    W. J. Goedheer,; Land, V.

    2008-01-01

    In dusty radio-frequency (RF) discharges under micro-gravity conditions often a void is observed, a dust free region in the discharge center. This void is generated by the drag of the positive ions pulled out of the discharge by the electric field. We have developed a hydrodynamic model for dusty RF

  17. Assembly of filamentary void galaxy configurations

    NARCIS (Netherlands)

    Rieder, Steven; van de Weijgaert, Rien; Cautun, Marius; Beygu, Burcu; Zwart, Simon Portegies

    2013-01-01

    We study the formation and evolution of filamentary configurations of dark matter haloes in voids. Our investigation uses the high-resolution Lambda cold dark matter simulation CosmoGrid to look for void systems resembling the VGS_31 elongated system of three interacting galaxies that was recently

  18. The Hierarchical Structure and Dynamics of Voids

    CERN Document Server

    Aragon-Calvo, M A

    2012-01-01

    Contrary to the common view voids have very complex internal structure and dynamics. Here we show how the hierarchy of structures in the density field inside voids is reflected by a similar hierarchy of structures in the velocity field. Voids defined by dense filaments and clusters can de described as simple expanding domains with coherent flows everywhere except at their boundaries. At scales smaller that the void radius the velocity field breaks into expanding sub-domains corresponding to sub- voids. These sub-domains break into even smaller sub-sub domains at smaller scales resulting in a nesting hierarchy of locally expanding domains. The ratio between the magnitude of the velocity field responsible for the expansion of the void and the velocity field defining the sub voids is approximately one order of magnitude. The small-scale components of the velocity field play a minor role in the shaping of the voids but they define the local dynamics directly affecting the processes of galaxy formation and evoluti...

  19. Eating-related anxiety in individuals with eating disorders.

    Science.gov (United States)

    Webb, C M; Thuras, P; Peterson, C B; Lampert, J; Miller, D; Crow, S J

    2011-12-01

    Although previous research has supported the importance of anxiety as an etiological and maintenance factor for eating disorders, the specific mechanisms are not well understood. The role of anxiety in the context of eating behavior is especially unclear. The purpose of this study was to identify anxiety-eliciting eating situations and anxiety management strategies patients use to mitigate anxiety experienced in the context of eating as determined by diagnostic groups and symptom patterns. Fifty-three eating disorder outpatients were administered the Eating and Anxiety Questionnaire (EAQ) and the Eating Disorder Diagnostic Scale. Ratings indicated significant anxiety in most eating situations, whereas management strategies were more limited yet regularly employed. Factor analysis of the EAQ revealed a 6-factor solution for anxiety management strategies and a 4-factor solution for anxiety-eliciting situations. These results indicate patients with eating disorders report high levels of anxiety associated with eating behaviors but utilize limited yet consistent anxiety management strategies. Effective intervention strategies for managing eating-related anxiety should be incorporated into treatment and may need to be specified for different diagnostic subgroups.

  20. Personality traits in schizophrenia and related personality disorders.

    Science.gov (United States)

    Camisa, Kathryn M; Bockbrader, Marcia A; Lysaker, Paul; Rae, Lauren L; Brenner, Colleen A; O'Donnell, Brian F

    2005-01-30

    We investigated whether schizophrenia spectrum disorders share common personality characteristics or traits. Participants with a diagnosis of schizophrenia or schizoaffective disorder (SZ) or with a schizophrenia spectrum personality disorder (schizophrenia spectrum PD: schizoid, paranoid, and schizotypal personality disorder) were compared with non-psychiatric control subjects on the five-factor model of personality and the psychosis-proneness scales. On the five-factor personality scales, SZ subjects showed higher levels of neuroticism, and lower levels of openness, agreeableness, extraversion, and conscientiousness than control subjects. Higher scores on openness and lower scores on neuroticism distinguished schizophrenia spectrum PD from SZ. On the psychosis-proneness scales, both PD and SZ participants scored high relative to non-psychiatric control participants on magical ideation and perceptual aberration, while PD participants scored intermediate between non-psychiatric control participants and SZ on social anhedonia. Discriminant analysis indicated that schizophrenia spectrum patients could be distinguished from PDs by more severe social withdrawal and maladjustment, while subjects with PDs could be best distinguished from control subjects on the basis of odd or novel ideation and decreased conscientiousness.

  1. Work-Related Upper Limb Disorders: A Case Report

    Directory of Open Access Journals (Sweden)

    Zlatka Borisova Stoyneva

    2015-03-01

    Full Text Available In this study the complex interrelationship between physical factors, job stress, lifestyle and genetic factors on symptoms of work-related musculoskeletal disorders of the upper limbs is demonstrated by a case report and discussion of the literature. A 58 year old woman with long lasting complaints of the upper limbs with increasing intensity and duration, generalisation, combined with skin thickness, Raynaud’s phenomenon, joint disorders, arterial and pulmonary hypertension, metabolic lipid dysfunctions is presented. Occupational history proves continuous duration of service at a job with occupational physical static load with numerous repetitive monotonous systematic motions of fingers and hands as a weaver of Persian rugs followed by work at an automated loom and variable labour activities. Though the complaints dated since the time she was a manual weaver, the manifestations of generalized joint degenerative changes, system sclerosis with Raynaud’s phenomenon with similar upper extremities signs and symptoms discount upper limbs musculoskeletal disorder as caused only or mainly by occupational risk factors. The main principles and criteria for occupational diagnosis of musculoskeletal upper limb disorders and legislative requirements for their reglamentation are discussed.

  2. [The Marfan syndrome and related connective tissue disorders].

    Science.gov (United States)

    Siepe, Matthias; Löffelbein, Florian

    2009-06-01

    The Marfan syndrome is an inherited disorder of the connective tissue which is mainly caused by a mutation in the fibrillin-1 gene. The defect in the connective tissue protein can lead to several organ dysfunctions. For the life expectancy, the cardiovascular aspect is of paramount importance. Patients with Marfan syndrome may develop aortic aneurysms and valvular heart defects. The risk of aortic aneurysms consists in the development of aortic dissection or rupture with their fatal consequences. Besides the cardiovascular manifestation, the skeletal and ocular system can also be affected. The skeletal manifestation is often characterised by long limbs, arachnodactyly, and abnormal joint flexibility along with other signs. Patients may also have dislocated lenses, ectasia of the dural sac, stretch marks, spontaneous pneumothorax, recurrent hernia, or a family history suspicious for Marfan. During the past years, other related connective tissue disorders with analogous organ manifestation have been described (e.g., Loeys-Dietz syndrome). In this article we present the basic knowledge about these connective tissue disorders, and we mention new insights in the recently explored pathophysiology of the disorder which is a possible target for future medical treatment options. Furthermore, recent new concepts for the prophylactic treatment of the aortic manifestation are explained.

  3. VIDE: The Void IDentification and Examination toolkit

    CERN Document Server

    Sutter, P M; Hamaus, Nico; Pisani, Alice; Wandelt, Benjamin D; Warren, Michael S; Villaescusa-Navarro, Francisco; Zivick, Paul; Mao, Qingqing; Thompson, Benjamin B

    2014-01-01

    We present VIDE, the Void IDentification and Examination toolkit, an open-source Python/C++ code for finding cosmic voids in galaxy redshift surveys and N-body simulations, characterizing their properties, and providing a platform for more detailed analysis. At its core, VIDE uses a greatly enhanced version of ZOBOV (Neyinck 2008) to calculate a Voronoi tessellation for estimating the density field and a watershed transform to construct voids. The watershed levels are used to place voids in a hierarchical tree. VIDE provides significant additional functionality for both pre- and post-processing: for example, VIDE can work with volume- or magnitude-limited galaxy samples with arbitrary survey geometries, or dark matter particles or halo catalogs in a variety of common formats. It can also randomly subsample inputs and includes a Halo Occupation Distribution model for constructing mock galaxy populations. VIDE outputs a summary of void properties in plain ASCII, and provides a Python API to perform many analysi...

  4. The paraphilia-related disorders: an empirical investigation of nonparaphilic hypersexuality disorders in outpatient males.

    Science.gov (United States)

    Kafka, M P; Hennen, J

    1999-01-01

    The frequency distribution of nonparaphilic hypersexual behaviors was investigated in an outpatient sample of 206 consecutively evaluated males seeking help for sexual impulsivity disorders (SIDs), either paraphilia-related disorders (PRD; n = 63) or paraphilias (PA; n = 143). Paraphilia-related disorders associated with help-seeking behaviors included compulsive masturbation (sample prevalence, 69%), protracted heterosexual or homosexual promiscuity (51%), pornography dependence (50%), telephone-sex dependence (24%), and severe sexual desire incompatibility (12%). Eighty-six percent of the PA sample reported at least one lifetime PRD. The subgroup of males with both PAs and lifetime PRDs (n = 123) self-reported the greatest number of lifetime SIDs, the highest incidence of physical and sexual abuse, the fewest years of completed education, and the highest likelihood of current unemployment or disability. As well, the subgroup of males with PAs but no lifetime PRDs (n = 20) self-reported the fewest lifetime SIDs; this subgroup was not statistically different from the PRD group on these aforementioned variables. These data suggest that social disadvantage, as assessed in this sample, is associated with the cumulative incidence of SIDs but not necessarily with the diathesis to develop paraphilic disorders.

  5. Epilepsy and outcome in FOXG1-related disorders

    Science.gov (United States)

    Seltzer, Laurie E.; Ma, Mandy; Ahmed, Sohnee; Bertrand, Mary; Dobyns, William B.; Wheless, James; Paciorkowski, Alex R.

    2014-01-01

    Summary Objective FOXG1-related disorders are associated with severe intellectual disability, absent speech with autistic features, and epilepsy. Children with deletions or intragenic mutations of FOXG1 also have postnatal microcephaly, morphologic abnormalities of the corpus callosum, and choreiform movements. Duplications of 14q12 often present with infantile spasms, and have subsequent intellectual disability with autistic features. Long term epilepsy outcome and response to treatment has not been studied systematically in a well-described cohort of subjects with FOXG1-related disorders. We report on the epilepsy features and developmental outcome of 23 new subjects with deletions or intragenic mutations of FOXG1, and 7 subjects with duplications. Methods Subjects had either chromosomal microarray or FOXG1 gene sequencing performed as part of routine clinical care. Development and epilepsy follow-up data were collected from medical records from treating neurologists and through telephone parental interviews using standardized questionnaires. Results Epilepsy was diagnosed in 87% of the subjects with FOXG1-related disorders. The mean age of epilepsy diagnosis in FOXG1 duplications was significantly younger than those with deletions/intragenic mutations (p=0.0002). All of the duplication FOXG1 children with infantile spasms responded to hormonal therapy and only one required long-term anti-epileptic therapy. In contrast, more children with deletions/intragenic mutations required anti-epileptic drugs on follow-up (p<0.0005). All subjects with FOXG1-related disorders had neurodevelopmental disabilities after 3 years of age, regardless of the epilepsy type or intractability of seizures. All had impaired verbal language and social contact, and three duplication subjects were formally diagnosed with autism. Subjects with deletion/intragenic mutations however had significantly worse ambulation (p=0.04) and functional hand use (p<0.0005). Significance Epilepsy and

  6. Sleep-related breathing disorders and non-invasive ventilation

    Directory of Open Access Journals (Sweden)

    Agata Lax

    2015-05-01

    Full Text Available Non-invasive mechanical ventilation (NPPV was originally used in patients with acute respiratory impairment or exacerbations of chronic respiratory diseases, as an alternative to the endotracheal tube. Over the last thirty years NPPV has been also used at night in patients with stable chronic lung disease such as obstructive sleep apnea, the overlap syndrome (chronic obstructive pulmonary disease and obstructive sleep apnea, neuromuscular disorders, obesity-hypoventilation syndrome, and in other conditions such as sleep disorders associated with congestive heart failure (Cheyne-Stokes respiration. In this no-systematic review we discuss the different types of NPPV, the specific conditions in which they can be used and the indications, recommendations and evidence supporting the efficacy of NPPV. Optimizing patient acceptance and adherence to non-invasive ventilation treatment is challenging. The treatment of sleep-related disorders is a life-threatening condition. The optimal level of treatment should be determined in a sleep laboratory. Side effects directly affecting the patient’s adherence to treatment are known. The most common are nasopharyngeal symptoms including increased congestion and rhinorrhea; these effects are related to reduced humidity of inspired gas. Humidification of delivered gas may improve these symptoms.

  7. Management of acid-related disorders in patients with dysphagia.

    Science.gov (United States)

    Howden, Colin W

    2004-09-06

    Dysphagia affects a large and growing number of individuals in the United States, particularly the elderly and those who are neurologically impaired. Swallowing difficulties may be due to age-related changes in oropharyngeal and esophageal functioning as well as central nervous system diseases such as stroke, Parkinson disease, and dementia. Among institutionalized individuals, dysphagia is associated with increased morbidity and mortality. An appreciation of the physiology of swallowing and the pathophysiology of dysphagia is necessary for proper patient management. Careful history, physical examination, and evaluation of radiologic and endoscopic studies should differentiate oropharyngeal and esophageal etiologies of dysphagia and distinguish mechanical (anatomic) disorders from functional (motor) disorders. A significant percentage of patients with dysphagia have concomitant acid-related disorders that are managed best with proton pump inhibitor (PPI) therapy. Three of the currently available PPIs are manufactured as capsules containing enteric-coated granules that may be mixed with soft foods or fruit juices before oral administration to those with swallowing difficulties. In addition, omeprazole and lansoprazole may be administered via gastrostomy or nasogastric feeding tubes as suspensions in sodium bicarbonate. Novel dosage formulations of lansoprazole that may be appropriate for patients with dysphagia include the commercially manufactured lansoprazole strawberry-flavored enteric-coated granules for suspension and lansoprazole orally disintegrating tablets.

  8. Pharmacological treatment of refugees with trauma-related disorders

    DEFF Research Database (Denmark)

    Sonne, Charlotte; Lohmann, Jessica Mariana Carlsson; Bech, Per

    2017-01-01

    There is a dearth of evidence on the effectiveness of pharmacological treatment for refugees with trauma-related disorders. The present paper provides an overview of available literature on the subject and discusses the transferability of results from studies on other groups of patients with post...... traumatic stress disorder (PTSD). We conducted a systematic review of published treatment outcome studies on PTSD and depression among refugees. Fifteen studies were identified and reviewed. Most studies focused on the use of antidepressants. Included studies differed widely in method and quality....... The majority were observational studies and case studies. Small sample sizes limited the statistical power. Few studies reported effect sizes, confidence intervals, and statistical significance of findings. No specific pharmacological treatment for PTSD among refugees can be recommended on the basis...

  9. Sleep-related eating disorder secondary to zolpidem.

    Science.gov (United States)

    Nzwalo, Hipólito; Ferreira, Ligia; Peralta, Rita; Bentes, Carla

    2013-02-21

    Sleep-related eating disorder (SRED) is characterised by eating episodes during the first period of the night sleep with partial loss consciousness, and amnesia. It can rarely be induced by some drugs, including zolpidem. We present a video report of a patient with a 1-year history of SRED caused by zolpidem causing important repercussions in the sleep structure and life quality. The night eating episodes ceased promptly with discontinuation of zolpidem. Upon the follow-up, the sleep structure improved and the daily consequences disappeared. As in few reported cases of zolpidem-induced SRED, our patient was suffering from the parasomnia for a long time before the diagnosis. Active exclusion of symptoms suggestive of SRED in patients under zolpidem treatment can avoid the deleterious effect of the sleep disorder.

  10. Factors related to posttraumatic stress disorder in adolescence.

    Science.gov (United States)

    Nooner, Kate B; Linares, L Oriana; Batinjane, Jessica; Kramer, Rachel A; Silva, Raul; Cloitre, Marylene

    2012-07-01

    Studies of posttraumatic stress disorder (PTSD) in adolescence published from 2000 to 2011 indicate that adolescents are at greater risk of experiencing trauma than either adults or children, and that the prevalence of PTSD among adolescents is 3-57%. Age, gender, type of trauma, and repeated trauma are discussed as factors related to the increased rates of adolescent PTSD. PTSD in adolescence is also associated with suicide, substance abuse, poor social support, academic problems, and poor physical health. PTSD may disrupt biological maturational processes and contribute to the long-term emotion and behavior regulation problems that are often evident in adolescents with the disorder. Recommendations are presented for practice and research regarding the promotion of targeted prevention and intervention services to maximize adolescents' strengths and minimize vulnerabilities. Public policy implications are discussed.

  11. Characteristics of obesity and its related disorders in China.

    Science.gov (United States)

    Jia, Wei-Ping; Wang, Chen; Jiang, Shan; Pan, Jie-Min

    2010-02-01

    Obesity is a medical condition with excess body fat accumulation to the extent which leads to serious health consequences. Abdominal obesity, also known as central obesity, refers to the presence of excess fat in the abdominal area. Obesity, especially abdominal obesity, contributes to many metabolic disorders including metabolic syndrome (MetS), type 2 diabetes (T2DM) and cardiovascular diseases (CVD). The incidence of obesity has increased dramatically in recent years worldwide. In China, more than one-third of adults are overweight or obese and 10%-20% of all adults are affected by MetS. The pathogenesis underlying the abdominal obesity remains unclear. The ultimate health outcome of obesity and its related metabolic disorders haveprompted physicians to take aggressive treatments (lifestyle changes, pharmacological interventions and surgical therapies) before a serious consequence becomes clinically apparent. In this review, we discuss the prevalence, pathogenesis and clinic features of obesity in China.

  12. Cosmic voids and void lensing in the Dark Energy Survey Science Verification data

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez, C.; Clampitt, J.; Kovacs, A.; Jain, B.; García-Bellido, J.; Nadathur, S.; Gruen, D.; Hamaus, N.; Huterer, D.; Vielzeuf, P.; Amara, A.; Bonnett, C.; DeRose, J.; Hartley, W. G.; Jarvis, M.; Lahav, O.; Miquel, R.; Rozo, E.; Rykoff, E. S.; Sheldon, E.; Wechsler, R. H.; Zuntz, J.; Abbott, T. M. C.; Abdalla, F. B.; Annis, J.; Benoit-Lévy, A.; Bernstein, G. M.; Bernstein, R. A.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Rosell, A. Carnero; Kind, M. Carrasco; Carretero, J.; Crocce, M.; Cunha, C. E.; D' Andrea, C. B.; da Costa, L. N.; Desai, S.; Diehl, H. T.; Dietrich, J. P.; Doel, P.; Evrard, A. E.; Neto, A. Fausti; Flaugher, B.; Fosalba, P.; Frieman, J.; Gaztanaga, E.; Gruendl, R. A.; Gutierrez, G.; Honscheid, K.; James, D. J.; Krause, E.; Kuehn, K.; Lima, M.; Maia, M. A. G.; Marshall, J. L.; Melchior, P.; Plazas, A. A.; Reil, K.; Romer, A. K.; Sanchez, E.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Tarle, G.; Thomas, D.; Walker, A. R.; Weller, J.

    2016-10-26

    Galaxies and their dark matter halos populate a complicated filamentary network around large, nearly empty regions known as cosmic voids. Cosmic voids are usually identified in spectroscopic galaxy surveys, where 3D information about the large-scale structure of the Universe is available. Although an increasing amount of photometric data is being produced, its potential for void studies is limited since photometric redshifts induce line-of-sight position errors of $\\sim50$ Mpc/$h$ or more that can render many voids undetectable. In this paper we present a new void finder designed for photometric surveys, validate it using simulations, and apply it to the high-quality photo-$z$ redMaGiC galaxy sample of the Dark Energy Survey Science Verification (DES-SV) data. The algorithm works by projecting galaxies into 2D slices and finding voids in the smoothed 2D galaxy density field of the slice. Fixing the line-of-sight size of the slices to be at least twice the photo-$z$ scatter, the number of voids found in these projected slices of simulated spectroscopic and photometric galaxy catalogs is within 20% for all transverse void sizes, and indistinguishable for the largest voids of radius $\\sim 70$ Mpc/$h$ and larger. The positions, radii, and projected galaxy profiles of photometric voids also accurately match the spectroscopic void sample. Applying the algorithm to the DES-SV data in the redshift range $0.2voids with comoving radii spanning the range 18-120 Mpc/$h$, and carry out a stacked weak lensing measurement. With a significance of $4.4\\sigma$, the lensing measurement confirms the voids are truly underdense in the matter field and hence not a product of Poisson noise, tracer density effects or systematics in the data. It also demonstrates, for the first time in real data, the viability of void lensing studies in photometric surveys.

  13. Parental educational practices in relation to children's anxiety disorder-related behavior.

    Science.gov (United States)

    Mellon, Robert C; Moutavelis, Adrianos G

    2011-08-01

    Schoolchildren reported their parents' use of aversive control and positive reinforcement contingencies in their educational interventions, as well as parental non-responsiveness to their requests for educational assistance. They also reported their own levels of six dimensions of anxiety disorder-related phenomena. Both parental use of aversive control and non-responsiveness were directly related to overall levels of child anxiety disorder-related behavior; these correlations were more robust than those observed in previous investigations of more diffuse dimensions of parenting style and trait anxiety. Panic disorder/agoraphobia and Generalized anxiety disorder were the dimensions most strongly correlated with both parental aversive control and non-responsiveness, while Compulsive behavior was uniquely uncorrelated with parental non-responsiveness and uniquely correlated with parental use of positive reinforcement contingencies. Differences in the magnitudes of correlations between anxiety disorder-related dimensions and parental educational practices are interpreted in terms of the probable differential effectiveness of their constituent behaviors in terminating parent-mediated negative reinforcers.

  14. Redshift-space distortions around voids

    CERN Document Server

    Cai, Yan-Chuan; Peacock, John A; Padilla, Nelson

    2016-01-01

    We have derived estimators for the linear growth rate of density fluctuations using the cross-correlation function of voids and haloes in redshift space, both directly and in Fourier form. In linear theory, this cross-correlation contains only monopole and quadrupole terms. At scales greater than the void radius, linear theory is a good match to voids traced out by haloes in N-body simulations; small-scale random velocities are unimportant at these radii, only tending to cause small and often negligible elongation of the redshift-space cross-correlation function near its origin. By extracting the monopole and quadrupole from the cross-correlation function, we measure the linear growth rate without prior knowledge of the void profile or velocity dispersion. We recover the linear growth parameter $\\beta$ to 9% precision from an effective volume of 3(Gpc/h)^3 using voids with radius greater than 25Mpc/h. Smaller voids are predominantly sub-voids, which may be more sensitive to the random velocity dispersion; the...

  15. Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders.

    Science.gov (United States)

    Cai, Huan; Cong, Wei-na; Ji, Sunggoan; Rothman, Sarah; Maudsley, Stuart; Martin, Bronwen

    2012-01-01

    Alzheimer's disease and other related neurodegenerative diseases are highly debilitating disorders that affect millions of people worldwide. Efforts towards developing effective treatments for these disorders have shown limited efficacy at best, with no true cure to this day being present. Recent work, both clinical and experimental, indicates that many neurodegenerative disorders often display a coexisting metabolic dysfunction which may exacerbate neurological symptoms. It stands to reason therefore that metabolic pathways may themselves contain promising therapeutic targets for major neurodegenerative diseases. In this review, we provide an overview of some of the most recent evidence for metabolic dysregulation in Alzheimer's disease, Huntington's disease, and Parkinson's disease, and discuss several potential mechanisms that may underlie the potential relationships between metabolic dysfunction and etiology of nervous system degeneration. We also highlight some prominent signaling pathways involved in the link between peripheral metabolism and the central nervous system that are potential targets for future therapies, and we will review some of the clinical progress in this field. It is likely that in the near future, therapeutics with combinatorial neuroprotective and 'eumetabolic' activities may possess superior efficacies compared to less pluripotent remedies.

  16. Sleep-related eating disorder and its associated conditions.

    Science.gov (United States)

    Inoue, Yuichi

    2015-06-01

    Sleep-related eating disorder (SRED) is a condition characterized by recurrent episodes of eating at the transition from night-time sleep to arousal. SRED patients describe eating in an out-of-control manner with preference for high-caloric foods and sometimes with inedible or toxic items. Level of consciousness during SRED episodes ranges from partial consciousness to dense unawareness typical of somnambulistic episodes. SRED is sometimes associated with psychotropic medication, in particular sedative hypnotics, and other sleep disorders, including parasomnias, narcolepsy, and restless legs syndrome. Night eating syndrome (NES) is another important condition in the disordered night-time eating spectrum showing hyperphagia episodes at full arousal from nocturnal sleep without accompanying amnesia. NES could be considered an abnormality in the circadian rhythm of meal timing with a normal circadian timing of sleep onset. The two conditions often overlap and possibly share a common pathophysiology. Studies have suggested that central nervous system serotonin modulation may lead to an effective treatment of NES, while the anti-seizure medication topiramate may be an effective SRED treatment.

  17. Body-Related Social Comparison and Disordered Eating among Adolescent Females with an Eating Disorder, Depressive Disorder, and Healthy Controls

    Directory of Open Access Journals (Sweden)

    Daniel Le Grange

    2012-09-01

    Full Text Available The purpose of this study was to investigate the association between body-related social comparison (BRSC and eating disorders (EDs by: (a comparing the degree of BRSC in adolescents with an ED, depressive disorder (DD, and no psychiatric history; and (b investigating whether BRSC is associated with ED symptoms after controlling for symptoms of depression and self-esteem. Participants were 75 girls, aged 12–18 (25 per diagnostic group. To assess BRSC, participants reported on a 5-point Likert scale how often they compare their body to others’. Participants also completed a diagnostic interview, Eating Disorders Inventory-2 (EDI-2, Beck Depression Inventory-II (BDI-II, and Rosenberg Self-Esteem Scale (RSE. Compared to adolescents with a DD and healthy adolescents, adolescents with an ED engaged in significantly more BRSC (p ≤ 0.001. Collapsing across groups, BRSC was significantly positively correlated with ED symptoms (p ≤ 0.01, and these associations remained even after controlling for two robust predictors of both ED symptoms and social comparison, namely BDI-II and RSE. In conclusion, BRSC seems to be strongly related to EDs. Treatment for adolescents with an ED may focus on reducing BRSC.

  18. Attitudes toward orthorexia nervosa relative to DSM-5 eating disorders.

    Science.gov (United States)

    Simpson, Courtney C; Mazzeo, Suzanne E

    2017-07-01

    A pattern of disordered eating involving a pathological fixation with healthy food consumption, labeled orthorexia nervosa (ON), has recently generated attention; however, research has not yet investigated perceptions of ON-related behaviors. This study examined potential stigmatization of ON, compared with DSM-5 ED diagnoses. Participants (N = 505) were randomly assigned to read a vignette depicting a woman with anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), or ON. They then answered questions about the individual depicted in the vignette. A series of MANOVAs investigated whether opinions and beliefs about the person depicted varied as a function of the disorder described in the vignette. Individuals with ON were perceived as less likely to "improve with treatment" than individuals with BN, and less likely to "pull themselves together," than individuals with BED. Individuals with ON and AN were viewed as "hard[er] to talk to" and more of a "danger to others" compared with individuals with BED. ON was viewed as less distressing, less likely to evoke sympathy, and more acceptable than the other disorders. Finally, "poor living choices" were perceived as contributing more substantially to ON. Participants' attributions of various personality characteristics did not differ based on ED diagnosis. Results suggest that ON is viewed as less severe, more desirable, and more often the result of personal life choices. However, findings also imply that ON is associated with stigma, similar to DSM-5 EDs. These negative attitudes might reinforce ON behaviors, and limit awareness of their potential complications. © 2017 Wiley Periodicals, Inc.

  19. Practical Statistics for the Voids Between Galaxies

    Directory of Open Access Journals (Sweden)

    Zaninetti, L.

    2010-12-01

    Full Text Available The voids between galaxies are identified withthe volumes of the Poisson Voronoi tessellation.Two new survival functions for the apparent radii of voids are derived. The sectional normalized area ofthe Poisson Voronoi tessellation is modelledby the Kiang function and by the exponential function. Two new survival functions with equivalent sectional radius are therefore derived; they represent an alternative to the survival function of voids between galaxies as given by the self-similar distribution. The spatial appearance of slices of the 2dF Galaxy Redshift Survey is simulated.

  20. On the linearity of tracer bias around voids

    Science.gov (United States)

    Pollina, Giorgia; Hamaus, Nico; Dolag, Klaus; Weller, Jochen; Baldi, Marco; Moscardini, Lauro

    2017-07-01

    The large-scale structure of the Universe can be observed only via luminous tracers of the dark matter. However, the clustering statistics of tracers are biased and depend on various properties, such as their host-halo mass and assembly history. On very large scales, this tracer bias results in a constant offset in the clustering amplitude, known as linear bias. Towards smaller non-linear scales, this is no longer the case and tracer bias becomes a complicated function of scale and time. We focus on tracer bias centred on cosmic voids, i.e. depressions of the density field that spatially dominate the Universe. We consider three types of tracers: galaxies, galaxy clusters and active galactic nuclei, extracted from the hydrodynamical simulation Magneticum Pathfinder. In contrast to common clustering statistics that focus on auto-correlations of tracers, we find that void-tracer cross-correlations are successfully described by a linear bias relation. The tracer-density profile of voids can thus be related to their matter-density profile by a single number. We show that it coincides with the linear tracer bias extracted from the large-scale auto-correlation function and expectations from theory, if sufficiently large voids are considered. For smaller voids we observe a shift towards higher values. This has important consequences on cosmological parameter inference, as the problem of unknown tracer bias is alleviated up to a constant number. The smallest scales in existing data sets become accessible to simpler models, providing numerous modes of the density field that have been disregarded so far, but may help to further reduce statistical errors in constraining cosmology.

  1. Work-related musculoskeletal disorders among occupational therapists in Korea.

    Science.gov (United States)

    Park, JuHyung

    2015-12-01

    [Purpose] The purpose of the study was to identify general characteristics of occupational therapists in Korea and to investigate the present conditions of their work-related musculoskeletal disorders (WRMD) in order to present preliminary data for its prevention and directions for improvement. [Subjects and Methods] This study was conducted by performing a survey about WRMD among 95 occupational therapists working in Korea. Frequency analysis was conducted for the work-related general characteristics of subjects and for parts of the body with musculoskeletal disorder, and a χ(2) test was used to analyze the association between the presence of WRMD characteristics and each general characteristic. [Results] The parts of the body involved the most were the shoulders, hands, and neck (in decreasing order), and the work-related general characteristics shown to be associated with WRMD were the gender and the mean length of employment period. [Conclusion] The results of this study revealed that occupational therapists in Korea were extremely vulnerable to WRMD, and that realistic measures should be prepared swiftly for its prevention and treatment.

  2. Nasal obstruction may alleviate bruxism related temporomandibular joint disorders.

    Science.gov (United States)

    Bektas, Devrim; Cankaya, Mustafa; Livaoglu, Murat

    2011-02-01

    Temporomandibular disorder (TMD) is a collective term used to identify a group of musculoskeletal conditions of the temporomandibular region. Bruxism is a non-functional activity characterized by repeated tooth clenching or grinding in an unconscious manner. Over the time bruxism may lead to TMD by the uploading it causes. Nasal obstruction is a common complaint that necessitates mouth breathing when severe. The treatment of bruxism is frequently performed by oral appliances, which induce occlusal disengagement and relax jaw musculature and therefore reduce the force on the temporomandibular joint (TMJ). We believe that nasal obstruction may indirectly have a preemptive and therapeutic effect on sleep bruxism related TMD by causing mouth breathing.

  3. Work-related posttraumatic upper limb disorder. A case report.

    Science.gov (United States)

    Capodaglio, P; Nigrelli, M P; Malaguti, S; Panigazzi, M; Pierobon, A

    1999-01-01

    In this paper we describe a patient with mor-sensory loss in the right forearm and hand, which persisted more than 2 years after work-related crush trauma of the left hand. Radiographic and electromyographic investigations, somatosensory evoked potentials, CT scans of the encephalus as well as the Minnesota Multiphasic Personality Inventory and the Roarschach test have been performed. On the basis of these investigations, we think this represents a case of conversion disorder with somatic features. Included is a brief overview of other psychological illness with physical findings involving the upper limb.

  4. Clinical and diagnostic aspects of gluten related disorders

    OpenAIRE

    Tovoli, Francesco; Masi, Chiara; Guidetti, Elena; Negrini, Giulia; PATERINI, PAOLA; Bolondi, Luigi

    2015-01-01

    Gluten is one of the most abundant and widely distributed components of food in many areas. It can be included in wheat, barley, rye, and grains such as oats, barley, spelt, kamut, and triticale. Gluten-containing grains are widely consumed; in particular, wheat is one of the world’s primary sources of food, providing up to 50% of the caloric intake in both industrialized and developing countries. Until two decades ago, celiac disease (CD) and other gluten-related disorders were believed to b...

  5. The lensing and temperature imprints of voids on the Cosmic Microwave Background

    CERN Document Server

    Cai, Yan-Chuan; Mao, Qingqing; Peacock, John A; Szapudi, Istvan; Berlind, Andreas A

    2016-01-01

    We have searched for the signature of cosmic voids in the CMB, in both the Planck temperature and lensing-convergence maps; voids should give decrements in both. We use zobov voids from the DR12 SDSS CMASS galaxy sample. We base our analysis on N-body simulations, to avoid a posteriori bias. For the first time, we detect the signature of voids in CMB lensing: the significance is $4.0\\sigma$, close to $\\Lambda$CDM in both amplitude and projected density-profile shape. A temperature dip is also seen, at modest significance ($1.6\\sigma$), with amplitude about 6 times the prediction. This temperature signal is induced mostly by voids with radius between 100 and 150 Mpc/h, while the lensing signal is mostly contributed by smaller voids -- as expected; lensing relates directly to density, while ISW depends on gravitational potential. The void abundance in observations and simulations agree, as well. We also repeated the analysis excluding lower-significance voids: no lensing signal is detected, with an upper limit ...

  6. The darkness that shaped the void: dark energy and cosmic voids

    CERN Document Server

    Bos, E G Patrick; Dolag, Klaus; Pettorino, Valeria

    2012-01-01

    Aims: We assess the sensitivity of void shapes to the nature of dark energy that was pointed out in recent studies. We investigate whether or not void shapes are useable as an observational probe in galaxy redshift surveys. We focus on the evolution of the mean void ellipticity and its underlying physical cause. Methods: We analyse the morphological properties of voids in five sets of cosmological N-body simulations, each with a different nature of dark energy. Comparing voids in the dark matter distribution to those in the halo population, we address the question of whether galaxy redshift surveys yield sufficiently accurate void morphologies. Voids are identified using the parameter free Watershed Void Finder. The effect of redshift distortions is investigated as well. Results: We confirm the statistically significant sensitivity of voids in the dark matter distribution. We identify the level of clustering as measured by \\sigma_8(z) as the main cause of differences in mean void shape . We find that in the h...

  7. Cosmic voids and void lensing in the Dark Energy Survey Science Verification data

    Science.gov (United States)

    Sánchez, C.; Clampitt, J.; Kovacs, A.; Jain, B.; García-Bellido, J.; Nadathur, S.; Gruen, D.; Hamaus, N.; Huterer, D.; Vielzeuf, P.; Amara, A.; Bonnett, C.; DeRose, J.; Hartley, W. G.; Jarvis, M.; Lahav, O.; Miquel, R.; Rozo, E.; Rykoff, E. S.; Sheldon, E.; Wechsler, R. H.; Zuntz, J.; Abbott, T. M. C.; Abdalla, F. B.; Annis, J.; Benoit-Lévy, A.; Bernstein, G. M.; Bernstein, R. A.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Rosell, A. Carnero; Kind, M. Carrasco; Carretero, J.; Crocce, M.; Cunha, C. E.; D'Andrea, C. B.; da Costa, L. N.; Desai, S.; Diehl, H. T.; Dietrich, J. P.; Doel, P.; Evrard, A. E.; Neto, A. Fausti; Flaugher, B.; Fosalba, P.; Frieman, J.; Gaztanaga, E.; Gruendl, R. A.; Gutierrez, G.; Honscheid, K.; James, D. J.; Krause, E.; Kuehn, K.; Lima, M.; Maia, M. A. G.; Marshall, J. L.; Melchior, P.; Plazas, A. A.; Reil, K.; Romer, A. K.; Sanchez, E.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Tarle, G.; Thomas, D.; Walker, A. R.; Weller, J.; DES Collaboration

    2017-02-01

    Cosmic voids are usually identified in spectroscopic galaxy surveys, where 3D information about the large-scale structure of the Universe is available. Although an increasing amount of photometric data is being produced, its potential for void studies is limited since photometric redshifts induce line-of-sight position errors of ≥50 Mpc h-1which can render many voids undetectable. We present a new void finder designed for photometric surveys, validate it using simulations, and apply it to the high-quality photo-z redMaGiC galaxy sample of the DES Science Verification data. The algorithm works by projecting galaxies into 2D slices and finding voids in the smoothed 2D galaxy density field of the slice. Fixing the line-of-sight size of the slices to be at least twice the photo-z scatter, the number of voids found in simulated spectroscopic and photometric galaxy catalogues is within 20 per cent for all transverse void sizes, and indistinguishable for the largest voids (Rv ≥ 70 Mpc h-1). The positions, radii, and projected galaxy profiles of photometric voids also accurately match the spectroscopic void sample. Applying the algorithm to the DES-SV data in the redshift range 0.2 < z < 0.8, we identify 87 voids with comoving radii spanning the range 18-120 Mpc h-1, and carry out a stacked weak lensing measurement. With a significance of 4.4σ, the lensing measurement confirms that the voids are truly underdense in the matter field and hence not a product of Poisson noise, tracer density effects or systematics in the data. It also demonstrates, for the first time in real data, the viability of void lensing studies in photometric surveys.

  8. Relative contribution of attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and tic severity to social and behavioral problems in tic disorders

    NARCIS (Netherlands)

    Hoekstra, PJ; Steenhuis, MP; Troost, PW; Korf, J; Kallenberg, CGM; Minderaa, RB

    2004-01-01

    The aim of this study was to investigate social and behavioral problems related to attention-deficit hyperactivity disorder (ADHD), obsessions and compulsions, and tic severity in children with a tic disorder. Parents of 58 children with a tic disorder with and without different forms of ADHD comple

  9. Relative contribution of attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and tic severity to social and behavioral problems in tic disorders

    NARCIS (Netherlands)

    Hoekstra, PJ; Steenhuis, MP; Troost, PW; Korf, J; Kallenberg, CGM; Minderaa, RB

    The aim of this study was to investigate social and behavioral problems related to attention-deficit hyperactivity disorder (ADHD), obsessions and compulsions, and tic severity in children with a tic disorder. Parents of 58 children with a tic disorder with and without different forms of ADHD

  10. Relative contribution of attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and tic severity to social and behavioral problems in tic disorders

    NARCIS (Netherlands)

    Hoekstra, PJ; Steenhuis, MP; Troost, PW; Korf, J; Kallenberg, CGM; Minderaa, RB

    2004-01-01

    The aim of this study was to investigate social and behavioral problems related to attention-deficit hyperactivity disorder (ADHD), obsessions and compulsions, and tic severity in children with a tic disorder. Parents of 58 children with a tic disorder with and without different forms of ADHD comple

  11. WORK RELATED MUSCULOSKELETAL DISORDERS: A SURVEY OF PHYSIOTHERAPISTS IN TRICITY

    Directory of Open Access Journals (Sweden)

    Priyanka Maheshwari

    2015-12-01

    Full Text Available Background: Musculoskeletal system disorders are common among health care workers worldwide. They are common causes of severe long-term pain and physical disability. Musculoskeletal disorders (MSDs are defined as “regional impairments of the muscles, tendons, nerves and joints. Physiotherapy can lead to WRMSDs in physiotherapist because of the nature of their profession. Despite of having expert knowledge of musculoskeletal injuries and injury prevention strategies they still report a high incidence of work-related injuries during their professional practice due to their training and continuous professional development Methods: A total of 100 Physiotherapists which included 78 females and 22 males in the age group of 21 to 40 years were recruited in the study. The subjects were taken as per the inclusion and exclusion criteria from Tricity. Results: Pearson’s correlation and Chi square analysis was used to determine correlation and the association of prevalence of self-reported musculoskeletal symptoms with personal characteristics, job risk factors and coping strategies. The data obtained from this study documents that majority of Physiotherapists have experienced WRMSDs at some time. The prevalence of WRMSDs among Physiotherapists in Tricity is high (91%. The most common risk factors identified in the present study were dealing with an excessive number of patients in one day; continuing to work while injured or hurt; lifting or transferring dependent patients and work scheduling. In present study, the low back and neck regions were the most commonly affected site among physiotherapists (72.5% each followed by upper back (28.6 %, shoulder (20.9%, wrist and hand (17.6%, knee (12.1%, ankle and foot (12.1% and hip (7.70% Conclusions: Work-related musculoskeletal disorders are an important health risk within the physiotherapy profession. The prevalence of work-related musculoskeletal disorders among the Physiotherapists in Tricity is high that

  12. Characteristics of binge eating disorder in relation to diagnostic criteria

    Directory of Open Access Journals (Sweden)

    Wilfley DE

    2016-08-01

    Full Text Available Denise E Wilfley,1 Leslie Citrome,2 Barry K Herman3 1Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 2Department of Psychiatry & Behavioral Sciences, New York Medical College, Valhalla, NY, 3Global Medical Affairs, Shire, Lexington, MA, USA Abstract: The objective of this review was to examine the evidentiary basis for binge eating disorder (BED with reference to the Diagnostic and Statistical Manual of Mental Disorders – Fifth Edition (DSM-5 diagnostic criteria for BED. A PubMed search restricted to titles and abstracts of English-language reviews, meta-analyses, clinical trials, randomized controlled trials, journal articles, and letters using human participants was conducted on August 7, 2015, using keywords that included “binge eating disorder,” DSM-5, DSM-IV, guilt, shame, embarrassment, quantity, psychological, behavior, and “shape and weight concerns.” Of the 257 retrieved publications, 60 publications were considered relevant to discussions related to DSM-5 diagnostic criteria and were included in the current review, and 20 additional references were also included on the basis of the authors’ knowledge and/or on a review of the reference lists from relevant articles obtained through the literature search. Evidence supports the duration/frequency criterion for BED and the primary importance of loss of control and marked distress in identifying individuals with BED. Although overvaluation of shape/weight is not a diagnostic criterion, its relationship to the severity of BED psychopathology may identify a unique subset of individuals with BED. Additionally, individuals with BED often exhibit a clinical profile consisting of psychiatric (eg, mood, obsessive–compulsive, and impulsive disorders and medical (eg, gastrointestinal symptoms, metabolic syndrome, and type 2 diabetes comorbidities and behavioral profiles (eg, overconsumption of calories outside of a binge eating episode and emotional

  13. Processing art sculptures relative to the issue of eating disorders

    OpenAIRE

    KONEČNÁ, Monika

    2016-01-01

    This thesis deals with the problems of eating disorders. Objective of the thesis is definition of eating disorder, a description of the individual faults an as a practical part there is an artistic creation of specific disorders. Theoretical part includes characteristics, division and insight into history. There are described four forms of eating disorders: anorexia, bulimia, obesity and bigorexia. In the practical part is the visual processing of transformation of two excessive eating disord...

  14. Properties of Galaxies in and around Voids

    CERN Document Server

    Hopp, U

    1997-01-01

    Two surveys for intrinsically faint galaxies towards nearby voids have been conducted at the MPI für Astronomie, Heidelberg. One selected targets from a new diameter limited ($\\Phi \\ge 5''$) catalog with morphological criteria while the other used digitized objective prism Schmidt plates to select mainly HII dwarf galaxies. For some 450 galaxies, redshifts and other optical data were obtained. We studied the spatial distribution of the sample objects, their luminosity function, and their intrinsic properties. Most of the galaxies belong to already well known sheets and filaments. But we found about a dozen highly isolated galaxies in each sample (nearest neighborhood distance $\\ge 3 h_{75}^{-1} Mpc$). These tend to populate additional structures and are not distributed homogeneously throughout the voids. As our results on 'void galaxies' still suffer from small sample statistics, I also tried to combine similar existing surveys of nearby voids to get further hints on the larger structure and on the luminosit...

  15. Underground void filling by cemented mill tailings

    Institute of Scientific and Technical Information of China (English)

    Choudhary Bhanwar Singh; Kumar Santosh

    2013-01-01

    Underground mining always create voids. These voids can cause subsidence of surface. So it is always a demand to fill the void in such a manner that the effect of underground mining can be minimized. Void filling using mill tailings especially in metal mining is one of the best techniques. The tailings produced in milling process have traditionally been disposed in tailing ponds creating a waste disposal and environ-mental problems in terms of land degradation, air and water pollution, etc. This disposal practice is more acute in the metal milling industry where the fine grinding, required for value liberation, results in the production of very fine tailings in large percentage. This paper includes discussions on the effectiveness of different paste mixes with varying cement contents in paste backfilling operations. The results revealed that material composition and use of super plasticizer strongly influenced the strength of cemented backfill.

  16. Topology optimization with flexible void area

    DEFF Research Database (Denmark)

    Clausen, Anders; Aage, Niels; Sigmund, Ole

    2014-01-01

    This paper presents a methodology for including fixed-area flexible void domains into the minimum compliance topology optimization problem. As opposed to the standard passive elements approach of rigidly specifying void areas within the design domain, the suggested approach allows these areas...... to be flexibly reshaped and repositioned subject to penalization on their moments of inertia, the positions of their centers of mass, and their shapes. The flexible void areas are introduced through a second, discrete design variable field, using the same discretization as the standard field of continuous...... density variables. The formulation is based on a combined approach: The primary sub-problem is to minimize compliance, subject to a volume constraint, with a secondary sub-problem of minimizing the disturbance from the flexible void areas. The design update is performed iteratively between the two...

  17. Neutron Imaging Calibration to Measure Void Fraction

    Energy Technology Data Exchange (ETDEWEB)

    Geoghegan, Patrick J [ORNL; Bilheux, Hassina Z [ORNL; Sharma, Vishaldeep [ORNL; Fricke, Brian A [ORNL

    2015-01-01

    Void fraction is an intuitive parameter that describes the fraction of vapor in a two-phase flow. It appears as a key variable in most heat transfer and pressure drop correlations used to design evaporating and condensing heat exchangers, as well as determining charge inventory in refrigeration systems. Void fraction measurement is not straightforward, however, and assumptions on the invasiveness of the measuring technique must be made. Neutron radiography or neutron imaging has the potential to be a truly non-invasive void fraction measuring technique but has until recently only offered qualitative descriptions of two-phase flow, in terms of flow maldistributions, for example. This paper describes the calibration approach necessary to employ neutron imaging to measure steady-state void fraction. Experiments were conducted at the High Flux Isotope Reactor (HFIR) Cold Guide 1D neutron imaging facility at Oak Ridge National Laboratory (ORNL), Oak Ridge, TN, USA.

  18. Void growth in metals: Atomistic calculations

    Energy Technology Data Exchange (ETDEWEB)

    Traiviratana, Sirirat [Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093 (United States); Bringa, Eduardo M. [Materials Science Department, Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Benson, David J. [Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093 (United States); Meyers, Marc A. [Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093 (United States); NanoEngineering, University of California, San Diego, La Jolla, CA 92093 (United States)], E-mail: mameyers@ucsd.edu

    2008-09-15

    Molecular dynamics simulations in monocrystalline and bicrystalline copper were carried out with LAMMPS (Large-scale Atomic/Molecular Massively Parallel Simulator) to reveal void growth mechanisms. The specimens were subjected to tensile uniaxial strains; the results confirm that the emission of (shear) loops is the primary mechanism of void growth. It is observed that many of these shear loops develop along two slip planes (and not one, as previously thought), in a heretofore unidentified mechanism of cooperative growth. The emission of dislocations from voids is the first stage, and their reaction and interaction is the second stage. These loops, forming initially on different {l_brace}1 1 1{r_brace} planes, join at the intersection, if the Burgers vector of the dislocations is parallel to the intersection of two {l_brace}1 1 1{r_brace} planes: a <1 1 0> direction. Thus, the two dislocations cancel at the intersection and a biplanar shear loop is formed. The expansion of the loops and their cross slip leads to the severely work-hardened region surrounding a growing void. Calculations were carried out on voids with different sizes, and a size dependence of the stress threshold to emit dislocations was obtained by MD, in disagreement with the Gurson model which is scale independent. This disagreement is most marked for the nanometer sized voids. The scale dependence of the stress required to grow voids is interpreted in terms of the decreasing availability of optimally oriented shear planes and increased stress required to nucleate shear loops as the void size is reduced. The growth of voids simulated by MD is compared with the Cocks-Ashby constitutive model and significant agreement is found. The density of geometrically necessary dislocations as a function of void size is calculated based on the emission of shear loops and their outward propagation. Calculations are also carried out for a void at the interface between two grains to simulate polycrystalline

  19. The relevance of personality traits in impulsivity-related disorders: From substance use disorders and gambling disorder to bulimia nervosa.

    Science.gov (United States)

    Del Pino-Gutiérrez, Amparo; Jiménez-Murcia, Susana; Fernández-Aranda, Fernando; Agüera, Zaida; Granero, Roser; Hakansson, Anders; Fagundo, Ana B; Bolao, Ferran; Valdepérez, Ana; Mestre-Bach, Gemma; Steward, Trevor; Penelo, Eva; Moragas, Laura; Aymamí, Neus; Gómez-Peña, Mónica; Rigol-Cuadras, Assumpta; Martín-Romera, Virginia; Menchón, José M

    2017-09-01

    Background and aims The main aim of this study was to analyze and describe the clinical characteristics and shared personality traits in different impulsivity-compulsivity spectrum disorders: substance use disorders (SUD), gambling disorder (GD), and bulimia nervosa (BN). The specific aims were to compare personality differences among individuals with pure SUD, BN with and without SUD, and GD with and without SUD. In addition, we assessed the differential predictive capacity of clinical and personality variables in relation to diagnostic subtype. Methods The sample comprised 998 subjects diagnosed according to DSM-IV-TR criteria: 101 patients were diagnosed with SUD, 482 with GD, 359 with BN, 11 with GD + SUD, and 45 patients with BN + SUD. Various assessment instruments were administered, as well as other clinical measures, to evaluate their predictive capacity. Results Marked differences in personality traits were observed between groups. Novelty seeking, harm avoidance, self-directedness, cooperation, and self-transcendence best differentiated the groups. Notably, novelty seeking was significantly higher in the two dual pathology subgroups. Patients with dual pathology showed the most dysfunctional personality profiles. Discussion and conclusion Our results indicate the existence of shared dysfunctional personality traits among the groups studied, especially in novelty seeking and self-directedness.

  20. Zipf's law for fractal voids and a new void-finder

    CERN Document Server

    Gaite, J

    2005-01-01

    Voids are a prominent feature of fractal point distributions but there is no precise definition of what is a void (except in one dimension). Here we propose a definition of voids that uses methods of discrete stochastic geometry, in particular, Delaunay and Voronoi tessellations, and we construct a new algorithm to search for voids in a point set. We find and rank-order the voids of suitable examples of fractal point sets in one and two dimensions to test whether Zipf's power-law holds. We conclude affirmatively and, furthermore, that the rank-ordering of voids conveys similar information to the number-radius function, as regards the scaling regime and the transition to homogeneity. So it is an alternative tool in the analysis of fractal point distributions with crossover to homogeneity and, in particular, of the distribution of galaxies.

  1. In search of empty places: Voids in the distribution of galaxies

    Science.gov (United States)

    Bucklein, Brian K.

    2010-12-01

    We investigate several techniques to identify voids in the galaxy distribution of matter in the universe. We utilize galaxy number counts as a function of apparent magnitude and Wolf plots to search a two- or three-dimensional data set in a pencil-beam fashion to locate voids within the field of view. The technique is able to distinguish between voids that represent simply a decrease in density as well as those that show a build up of galaxies on the front or back side of the void. This method turns out to be primarily useable only at relatively short range (out to about 200 Mpc). Beyond this distance, the characteristics indicating a void become increasingly difficult to separate from the statistical background noise. We apply the technique to a very simplified model as well as to the Millennium Run dark matter simulation. We then compare results with those obtained on the Sloan Digital Sky Survey. We also created the Watershed Void Examiner (WaVE) which treats densities in a fashion similar to elevation on a topographical map, and then we allow the "terrain" to flood. The flooded low-lying regions are identified as voids, which are allowed to grow and merge as the level of flooding becomes higher (the overdensity threshold increases). Void statistics can be calculated for each void. We also determine that within the Millennium Run semi-analytic galaxy catalog, the walls that separate the voids are permeable at a scale of 4 Mpc. For each resolution that we tested, there existed a characteristic density at which the walls could be penetrated, allowing a single void to grow to dominate the volume. With WaVE, we are able to get comparable results to those previously published, but often with fewer choices of parameters that could bias the results. We are also able to determine the the density at which the number of voids peaks for different resolutions as well as the expected number of void galaxies. The number of void galaxies is amazingly consistent at an

  2. A boy infant with sleep related rhythmic movement disorder showing arm banging

    Directory of Open Access Journals (Sweden)

    Jun Kohyama

    2014-09-01

    Discussion: We diagnosed him as having arm banging type of sleep related rhythmic movement disorder. To our knowledge, no precise description on this type of sleep related rhythmic movement disorder has been found. In addition, this patient seemed to be the youngest case of sleep related rhythmic movement disorder showing arm banging.

  3. Multicomponent Behavioral Treatment for Chronic Combat-Related Posttraumatic Stress Disorder: Trauma Management Therapy

    Science.gov (United States)

    Turner, Samuel M.; Beidel, Deborah C.; Frueh, B. Christopher

    2005-01-01

    Posttraumatic stress disorder (PTSD) is a severe and chronic mental disorder that is highly prevalent within Veterans Affairs (VA) Medical Centers. A severe psychiatric disorder, combat-related PTSD is typically accompanied by multiple comorbid psychiatric disorders, symptom chronicity, and extreme social maladjustment. Thus, PTSD is a complex…

  4. The lensing and temperature imprints of voids on the cosmic microwave background

    Science.gov (United States)

    Cai, Yan-Chuan; Neyrinck, Mark; Mao, Qingqing; Peacock, John A.; Szapudi, Istvan; Berlind, Andreas A.

    2017-04-01

    We have searched for the signature of cosmic voids in the cosmic microwave background (CMB), in both the Planck temperature and lensing-convergence maps; voids should give decrements in both. We use ZOBOV voids from the Data Release 12 Sloan Digital Sky Survey CMASS galaxy sample. We base our analysis on N-body simulations, to avoid a posteriori bias. For the first time, we detect the signature of voids in CMB lensing: the significance is 3.2σ, close to Λ cold dark matter (ΛCDM) in both amplitude and projected density-profile shape. A temperature dip is also seen, at modest significance (2.3σ), with an amplitude about six times the prediction. This temperature signal is induced mostly by voids with radii between 100 and 150 h-1 Mpc, while the lensing signal is mostly contributed by smaller voids - as expected; lensing relates directly to density, while integrated Sachs-Wolfe effect (ISW) depends on gravitational potential. The void abundance in observations and simulations agree as well. We also repeated the analysis excluding lower significance voids: no lensing signal is detected with an upper limit of about twice the ΛCDM prediction. But the mean temperature decrement now becomes non-zero at the 3.7σ level (similar to that found by Granett et al.), with an amplitude about 20 times the prediction. However, the observed dependence of temperature on void size is in poor agreement with simulations, whereas the lensing results are consistent with ΛCDM theory. Thus, the overall tension between theory and observations does not favour non-standard theories of gravity, despite the hints of an enhanced amplitude for the ISW effect from voids.

  5. Void Statistics and Void Galaxies in the 2dFGRS

    CERN Document Server

    von Benda-Beckmann, Alexander M

    2007-01-01

    For the 2dFGRS we study the properties of voids and of fainter galaxies within voids that are defined by brighter galaxies. Our results are compared with simulated galaxy catalogues from the Millenium simulation coupled with a semianalytical galaxy formation recipe. We derive the void size distribution and discuss its dependence on the faint magnitude limit of the galaxies defining the voids. While voids among faint galaxies are typically smaller than those among bright galaxies, the ratio of the void sizes to the mean galaxy separation reaches larger values. This is well reproduced in the mock galaxy samples studied. We provide analytic fitting functions for the void size distribution. Furthermore, we study the galaxy population inside voids defined by objects with $B_J -5\\log{h}< -20$ and diameter larger than 10 \\hMpc. We find a clear bimodality of the void galaxies similar to the average comparison sample. We confirm the enhanced abundance of galaxies in the blue cloud and a depression of the number of ...

  6. Cluster-Void Degeneracy Breaking: Dark Energy, Planck and the Largest Cluster & Void

    CERN Document Server

    Sahlén, Martin; Silk, Joseph

    2015-01-01

    Combining galaxy cluster and void abundances breaks the degeneracy between mean matter density $\\Omega_{\\rm m}$ and power spectrum normalization $\\sigma_8$. In a first for voids, we constrain $\\Omega_{\\rm m} = 0.21 \\pm 0.10$ and $\\sigma_8 = 0.95 \\pm 0.21$ for a flat $\\Lambda$CDM universe, using extreme-value statistics on the claimed largest cluster and void. The Planck-consistent results detect dark energy with two objects, independently of other dark energy probes. Cluster-void studies also offer complementarity in scale, density, and non-linearity - of particular interest for testing modified-gravity models.

  7. Work-related post-traumatic stress disorder.

    Science.gov (United States)

    Skogstad, M; Skorstad, M; Lie, A; Conradi, H S; Heir, T; Weisæth, L

    2013-04-01

    Work-related post-traumatic stress disorder (PTSD) is an important condition encountered by many occupational health practitioners. To carry out an in-depth review of the research on occupational groups that are at particular risk of developing work-related PTSD. A literature search was conducted in the databases OVID MEDLINE, OVID Embase, Ovid PsycINFO, ISI Web of Science and CSA Health and Safety Science Abstracts. Professionals such as police officers, firefighters and ambulance personnel often experience incidents that satisfy the stressor criterion for the PTSD diagnosis. Other professional groups such as health care professionals, train drivers, divers, journalists, sailors and employees in bank, post offices or in stores may also be subjected to work-related traumatic events. Work-related PTSD usually diminishes with time. Mental health problems prior to the traumatic event and weak social support increase the risk of PTSD. Prevention of work-related PTSD includes a sound organizational and psychosocial work environment, systematic training of employees, social support from colleagues and managers and a proper follow-up of employees after a critical event.

  8. HCV-related central and peripheral nervous system demyelinating disorders.

    Science.gov (United States)

    Mariotto, Sara; Ferrari, Sergio; Monaco, Salvatore

    2014-01-01

    Chronic infection with hepatitis C virus (HCV) is associated with a large spectrum of extrahepatic manifestations (EHMs), mostly immunologic/rheumatologic in nature owing to B-cell proliferation and clonal expansion. Neurological complications are thought to be immune-mediated or secondary to invasion of neural tissues by HCV, as postulated in transverse myelitis and encephalopathic forms. Primarily axonal neuropathies, including sensorimotor polyneuropathy, large or small fiber sensory neuropathy, motor polyneuropathy, mononeuritis, mononeuritis multiplex, or overlapping syndrome, represent the most common neurological complications of chronic HCV infection. In addition, a number of peripheral demyelinating disorders are encountered, such as chronic inflammatory demyelinating polyneuropathy, the Lewis-Sumner syndrome, and cryoglobulin-associated polyneuropathy with demyelinating features. The spectrum of demyelinating forms also includes rare cases of iatrogenic central and peripheral nervous system disorders, occurring during treatment with pegylated interferon. Herein, we review HCV-related demyelinating conditions, and disclose the novel observation on the significantly increased frequency of chronic demyelinating neuropathy with anti-myelin-associated glycoprotein antibodies in a cohort of 59 consecutive patients recruited at our institution. We also report a second case of neuromyelitis optica with serum IgG autoantibody against the water channel aquaporin-4. The prompt recognition of these atypical and underestimated complications of HCV infection is of crucial importance in deciding which treatment option a patient should be offered.

  9. Impulse control and related disorders in Parkinson's disease.

    Science.gov (United States)

    Weintraub, Daniel; Nirenberg, Melissa J

    2013-01-01

    Impulse control disorders (ICDs), such as compulsive gambling, buying, sexual behavior, and eating, are a serious and increasingly recognized complication of dopamine replacement therapy in Parkinson's disease (PD). Other impulsive-compulsive behaviors have been linked to dopaminergic medications; these include punding (stereotyped, repetitive, purposeless behaviors) and dopamine dysregulation syndrome (DDS; compulsive medication overuse). ICDs have been most closely related to the use of dopamine agonists (DAs), particularly at higher dosages; in contrast, DDS is primarily associated with shorter-acting, higher-potency dopaminergic medications, such as apomorphine and levodopa. Risk factors for ICDs may include male sex; younger age; younger age at PD onset; a pre-PD history of ICD(s); personal or family history of substance abuse; bipolar disorder; gambling problems; and impulsive personality traits. The primary treatment of ICDs in PD is discontinuation of DA therapy. Not all patients can tolerate this, however, due to worsening motor symptoms and/or DA withdrawal syndrome (a severe, stereotyped drug withdrawal syndrome similar to that of other psychostimulants). While psychiatric medications are frequently used to treat ICDs in the general population, there is no empirical evidence to suggest that they are effective in PD. Given the paucity of treatment options and potentially serious consequences of ICDs in PD, it is critical for patients to be monitored closely for their development. As empirically validated treatments for ICDs emerge, it will also be important to examine their efficacy and tolerability in individuals with comorbid PD.

  10. The Castleman's Disease and Related Disorders--A Case Report.

    Science.gov (United States)

    Khan, M K; Talukder, R H; Kamruzzaman, M

    2016-01-01

    Castleman's disease is a rare primary disease of the lymph nodes. Little is known about the management of the disease. Surgical treatment gives a very good result. What other modalities of treatment could be done is not yet established. The role of surgery gives good result and follow up evaluation is satisfactory. We found a solitary intra-abdominal mass of lymphoid hyperplasia with a histological diagnosis of Castlemans disease identified in the pathological data base. Unicentric disease was defined as it was a solitary mass. Clinical, Radiological and Laboratory data were analysed to evaluate treatment response. The patient also has related disorders as Acanthosis nigricans, Myoneuronal disorder as-MG and bronchiolitis. The patient diagnosed as angiofollicular hyperplasia (Castleman's disease). After evaluation patient under went surgical treatment, partial excision of tumor mass due to morbid adhesion with inferior vena cava. The patient becomes symptom free and lump disappears within 60 days of treatment. There was no recurrence of the disease after further evaluation. The author recommends that in Unicentric variant of Castlemans disease surgical resection of the tumor is curative. The unicentric tumour may be hyaline-vascular or hyaline-vascular/ plasma cell type. Partial resection, Radiotherapy or observation alone may avoid excessive aggressive therapy.

  11. Disorder-related effects in electron systems of low dimensionality

    Science.gov (United States)

    Gramada, Apostol

    1999-08-01

    This dissertation reports on research we have done on different topics in the physics of low-dimensional disordered electron systems. For two-dimensional systems in the presence of a magnetic field, we approach aspects related to the delocalized states (levitation, structure and position in multilayer systems) and the problem of generation of high harmonics of the cyclotron resonance. We estimate that the delocalized state ``levitate'' away from the center of the Landau level as the inverse of the fourth power of the magnetic field. In a two-layer system, the delocalized states repel each other in a manner similar to the usual level repulsion in quantum mechanics. We calculate the position and structure of the delocalized states. In the limit of the weak magnetic field, we establish the physics and develop the quantitative theory which explain the recent observation of the enhancement of the harmonics of the cyclotron resonance in this limit. For the case of one-dimensional systems, we study the effect of inhomogeneity on the tunnel density of states in a Luttinger liquid. We show that for a periodic inhomogeneity, an additional anomaly develops in the electron density of states and we find its position and magnitude. In the case of a disordered inhomogeneity, the plasmons associated with the low-energy excitations of the system become localized and, as a consequence, the correlator of the fluctuations of the densities of states is modified, acquiring an oscillatory dependence on the distance.

  12. Pharmacological Treatment of Cannabis-Related Disorders: A Narrative Review.

    Science.gov (United States)

    Gorelick, David A

    2016-01-01

    Cannabis is the most widely used illicit psychoactive substance world-wide, yet no medication is approved for the treatment of intoxication, withdrawal, or cannabis use disorder (CUD). To comprehensively review the current state of knowledge. Search of the PubMed electronic data base and review of reference lists of relevant articles to identify controlled clinical trials of pharmacological treatment. The search identified 4 trials for specific intoxication symptoms (none for global intoxication), 7 trials for withdrawal, and 12 phase II trials for CUD. One or two trials each suggest that propranolol is effective for some intoxication symptoms, antipsychotics for cannabis-induced psychosis, and dronabinol (synthetic THC) and gabapentin for cannabis withdrawal. Of 10 medications and one medication combination studied in 12 trials for CUD, only two medications were effective (in single trials): gabapentin and Nacetylcysteine (in adolescents). Not effective were dronabinol and several antidepressants, anticonvulsants, and antianxiety medications. Three trials of antidepressants for CUD with comorbid depression gave inconsistent results. A trial of atomoxetine for CUD with comorbid ADHD showed no efficacy. Five trials of second-generation antipsychotics for CUD with comorbid schizophrenia showed none better than any other. Further research is needed to confirm the efficacy of gabapentin for withdrawal and gabapentin and N-acetylcysteine for CUD and to develop new medications for all 3 cannabis-related disorders. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  13. Prevalence of work-related musculoskeletal disorders among hairdressers

    Directory of Open Access Journals (Sweden)

    Happiness Anulika Aweto

    2015-06-01

    Full Text Available Objectives: This study has investigated the prevalence of work-related musculoskeletal disorders (WMSDs, the most commonly affected body parts, the risk factors of WMSDs and the coping strategies adopted by hairdressers. Material and Methods: The study design was a cross-sectional descriptive survey design. Two hundred and ninety-nine hairdressers (242 females and 57 males from salons in Surulere and Mushin Local Government Areas of Lagos State completed a 27-item questionnaire. They were selected using a non-probability consecutive sampling technique. The inferential analysis was conducted using the Chi2 test. The level of significance stood at p < 0.05. Results: The 12-month prevalence of musculoskeletal disorders stood at 75.6%. Two hundred and twenty-one (91.3% participants reported gradual onset of musculoskeletal disorders. One hundred and sixteen (47.9% participants had the onset of the WMSDs at the age range of 26–35 years. The most commonly affected body parts included the low back (76.3%, shoulder (62.5% and neck (46.3%. Some of the major job risk factors of the WMSDs that were identified included: working in the same position for long periods and attending to a large number of customers in 1 day. Taking sufficient rest breaks by participants was one of the coping strategies adopted by the participants. The mean number of years of working experience was 7.85±0.4 years. One hundred and twenty-four (41.5% participants had worked for 1–5 years. The Chi2 analysis showed that the prevalence of musculoskeletal disorders were significantly associated with the age of a participant (Chi2 = 78.78, p = 0.001, years of working experience (Chi2 = 78.03, p = 0.001 and hours spent working in a standing position (Chi2 = 8.77, p = 0.01, respectively. Conclusions: The age of hairdressers, their years of working and the long hours they spent working in a standing position may be significant factors that contribute to the high prevalence of the WMSDs

  14. Empirically derived dietary patterns in relation to psychological disorders

    National Research Council Canada - National Science Library

    Hosseinzadeh, Mahdieh; Vafa, Mohammadreza; Esmaillzadeh, Ahmad; Feizi, Awat; Majdzadeh, Reza; Afshar, Hamidreza; Keshteli, Ammar Hassanzadeh; Adibi, Peyman

    2016-01-01

    Psychological disorders are highly prevalent worldwide. The present study aimed to investigate the relationship between major dietary patterns and prevalence of psychological disorders in a large sample of Iranian adults...

  15. Disorders Related to (And Sometimes Confused with) OCD

    Science.gov (United States)

    ... Like” OCD How This Disorder Differs from OCD Tic Disorders/Tourette Syndrome To learn more: Read the ... Visit the Tourette Syndrome Association Website . People with Tics/Tourette Syndrome and people with OCD both: Repeat ...

  16. Wheat-related disorders: A broad spectrum of 'evolving' diseases.

    Science.gov (United States)

    Gasbarrini, Gb; Mangiola, F

    2014-08-01

    Throughout the world, cereals have always been recognized as a fundamental food. Human evolution, through the development of cooking, led to the production of food rich in gluten, in order to take full advantage of the nutritional properties of this food. The result has been that gluten intolerance has arisen only in those populations that developed the art of cooking wheat. It is also recognized that wheat, one of the central elements of the Mediterranean diet, cannot be tolerated in some individuals. Among the wheat-related pathologies, coeliac disease is the best known: it is a chronic inflammatory condition affecting the gastrointestinal tract, which develops in genetically predisposed individuals. The most common manifestation is the malabsorption of nutrients. Recently, another wheat-related disease has appeared: non-coeliac gluten sensitivity, defined as the onset of a variety of manifestations related to wheat, rye and barley ingestion, in patients in whom coeliac disease and wheat allergy have been excluded. In this paper we will explore the damaging power of wheat, analysing the harmful process by which it realizes the onset of clinical manifestations associated with wheat-related disorders.

  17. Factors related to the comorbidity between oppositional defiant disorder and anxiety disorders in preschool children.

    Science.gov (United States)

    Martín, Virginia; Granero, Roser; Domènech, Josep Maria; Ezpeleta, Lourdes

    2017-03-01

    The aim of the study is to identify factors related to comorbid oppositional defiant disorder (ODD) and anxiety disorders (ADs). A sample of 622 children was assessed longitudinally at 3 and 5 years of age. At baseline, there were 310 boys (49.8%), most participants were of Caucasian-white ethnicity (89.1%) and attended to public school (64.0%), and families' socioeconomic status was 64.3% medium-high, 14.1% medium and 20.5% medium-low. Children diagnosed with ODD and/or AD were selected: n = 103 at 3 years of age (44 ODD, 42 AD and 17 ODD + AD) and n = 106 at 5 years of age (31 ODD, 60 AD and 15 ODD + AD). High levels of the child's negative affectivity and the mother's aggressive behavior (versus AD), and high scores in the father's psychopathology measurements (versus ODD) were related to the presence of comorbid ODD + AD at 3 years of age. High scores in approach-positive anticipation, fears (only in boys, in girls the reverse effect occurred) compared to ODD and AD independently and aggressive behavior (versus AD), and low scores for smiling and laughter (versus ODD only and AD only) were predictive of comorbidity at the 5 years of age. Temperament traits may be a common factor in explaining longitudinal ODD + AD comorbidity.

  18. A constitutive model for plastically anisotropic solids with non-spherical voids

    Science.gov (United States)

    Keralavarma, S. M.; Benzerga, A. A.

    2010-06-01

    Plastic constitutive relations are derived for a class of anisotropic porous materials consisting of coaxial spheroidal voids, arbitrarily oriented relative to the embedding orthotropic matrix. The derivations are based on nonlinear homogenization, limit analysis and micromechanics. A variational principle is formulated for the yield criterion of the effective medium and specialized to a spheroidal representative volume element containing a confocal spheroidal void and subjected to uniform boundary deformation. To obtain closed form equations for the effective yield locus, approximations are introduced in the limit-analysis based on a restricted set of admissible microscopic velocity fields. Evolution laws are also derived for the microstructure, defined in terms of void volume fraction, aspect ratio and orientation, using material incompressibility and Eshelby-like concentration tensors. The new yield criterion is an extension of the well known isotropic Gurson model. It also extends previous analyses of uncoupled effects of void shape and material anisotropy on the effective plastic behavior of solids containing voids. Preliminary comparisons with finite element calculations of voided cells show that the model captures non-trivial effects of anisotropy heretofore not picked up by void growth models.

  19. Influence of Grain Boundary Character on Creep Void Formation in Alloy 617

    Science.gov (United States)

    Lillo, Thomas; Cole, James; Frary, Megan; Schlegel, Scott

    2009-12-01

    Alloy 617, a high-temperature creep-resistant, nickel-based alloy, is being considered for the primary heat exchanger for the Next Generation Nuclear Plant (NGNP), which will operate at temperatures exceeding 760 °C and a helium pressure of approximately 7 MPa. Observations of the crept microstructure using optical microscopy indicate creep stress does not significantly influence the creep void fraction at a given creep strain over the relatively narrow set of creep conditions studied. Void formation was found to occur only after significant creep in the tertiary regime (>5 pct total creep strain) had occurred. Also, orientation imaging microscopy (OIM) was used to characterize the grain boundaries in the vicinity of creep voids that develop during high-temperature creep tests (900 °C to 1000 °C at creep stresses ranging from 20 to 40 MPa) terminated at creep strains ranging from 5 to 40 pct. Preliminary analysis of the OIM data indicates voids tend to form on grain boundaries parallel, perpendicular, or 45 deg to the tensile axis, while few voids are found at intermediate inclinations to the tensile axis. Random grain boundaries intersect most voids, while coincident site lattice (CSL)-related grain boundaries did not appear to be consistently associated with void development. Similar results were found in oxygen-free, high-conductivity (OFHC) copper, severely deformed using equal channel angular extrusion, and creep tested at 450 °C and 14 MPa.

  20. The relation between anger management style and organ system-related somatic symptoms in patients with depressive disorders and somatoform disorders.

    Science.gov (United States)

    Koh, Kyung Bong; Park, Joong Kyu

    2008-02-29

    The objective of this study was to examine the relation between anger management style and organ system- related somatic symptoms in depressive disorder and somatoform disorder patients. The subjects included 73 patients with depressive disorders and 47 with somatoform disorders. Anger management styles were assessed by the Anger Expression Scale, while the severity of organ system-related somatic symptoms was evaluated using the Somatic Stress Response Scale (SSRS). The severity of depression and hostility was assessed by the Symptom Checklist-90-Revised (SCL-90-R) depression and hostility subscales. The results of multiple regression analyses showed that, in depressive disorder patients, the level of anger expression was significantly associated with the severity of somatic symptoms related to neuromuscular, cardiorespiratory and gastrointestinal systems. However, in these patients, the level of anger suppression was not significantly associated with the severity of somatic symptoms related to any specific organ systems. In patients with somatoform disorders, there was no significant association between the level of anger suppression or anger expression and the severity of the somatic symptoms related to any specific organ systems. These results suggest that, in depressive disorder patients, anger expression is likely to be predominantly involved in the neuromuscular, cardiorespiratory and gastrointestinal organ systems. However, in each of depressive disorder and somatoform disorder patients, anger suppression is not likely to be associated with any specific organ systems.

  1. Analytical Description of Voids in Majumdar-Papapetrou Spacetimes

    CERN Document Server

    Varela, V

    1999-01-01

    We discuss new Majumdar-Papapetrou solutions for the 3+1 Einstein-Maxwell equations, with charged dust acting as the external source of the fields. The solutions satisfy non-linear potential equations which are related to well-known wave equations of 1+1 soliton physics. Although the matter distributions are not localised, they present central structures which may be identified with voids.

  2. Restless Eating, Restless Legs, and Sleep Related Eating Disorder.

    Science.gov (United States)

    Howell, Michael J

    2014-03-01

    Restless legs syndrome (RLS) often presents with a primary complaint of sleep initiation difficulty with only ambiguous allusions to motor symptoms. This may result in the condition being misdiagnosed as a psychophysiological insomnia. Further, nocturnal eating is common in RLS and like the classic motor symptoms, patients will describe an inability to initiate sleep until their urge (to eat) is addressed. Restless nocturnal eating arises, intensifies, and subsides in parallel to motor symptoms. Once misdiagnosed as psychophysiological insomnia, RLS patients are frequently treated with benzodiazepine receptor agonists. The CNS actions of these sedating agents, suppression of memory and executive function, unleash predisposed amnestic behaviors. In the case of RLS this would be expected to include the inappropriate ambulatory and eating behaviors of sleep related eating disorder (SRED). The evidence and implications of a link between the restless eating of RLS and SRED is presented here.

  3. Long Noncoding RNAs in Metabolic Syndrome Related Disorders

    Directory of Open Access Journals (Sweden)

    Magdalena Losko

    2016-01-01

    Full Text Available Ribonucleic acids (RNAs are very complex and their all functions have yet to be fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes comprise 67% of all genes and they are represented by housekeeping noncoding RNAs (transfer RNA (tRNA, ribosomal RNA (rRNA, small nuclear RNA (snRNA, and small nucleolar RNA (snoRNA that are engaged in basic cellular processes and by regulatory noncoding RNA (short and long noncoding RNA (ncRNA that are important for gene expression/transcript stability. In this review, we summarize data concerning the significance of long noncoding RNAs (lncRNAs in metabolic syndrome related disorders, focusing on adipose tissue and pancreatic islands.

  4. Should OCD leave the anxiety disorders in DSM-V? The case for obsessive compulsive-related disorders.

    Science.gov (United States)

    Hollander, Eric; Braun, Ashley; Simeon, Daphne

    2008-01-01

    Recently in 2006, a group of experts in obsessive compulsive disorder (OCD) and obsessive compulsive-related disorders (OCRDs) convened in Washington, DC, to review existing data on the relationships between these various disorders, and to suggest approaches to address the gaps in our knowledge, in preparation for the upcoming Diagnostic and Statistical Manual (Fifth Edition) (DSM-V). As a result of this meeting, the Research Planning Agenda for DSM-V: OCRD Work Group suggested removing OCD from the anxiety disorders, where it is currently found. This proposal is in accordance with the current International Classification of Mental Disorders (ICD-10) classification of OCD as a separate category from the anxiety disorders. Although the ICD-10 places both OCD and the anxiety disorders under the umbrella category of "neurotic, stress-related, and somatoform disorders," they are two separate categories, distinct from one another. As OCD and other putative OCRDs share aspects of phenomenology, comorbidity, neurotransmitter/peptide systems, neurocircuitry, familial and genetic factors, and treatment response, it was proposed to create a new category in DSM-V entitled OCRDs. Alternatively, the OCRDs might be conceptualized as a new category within the broader category of anxiety disorders. Future studies are needed to better define the relationships among these disorders, and to study boundary issues for this proposed category. There are both advantages and disadvantages in creating a new diagnostic category in DSM-V, and these are discussed in this article.

  5. 38 CFR 3.207 - Void or annulled marriage.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Void or annulled marriage... Void or annulled marriage. Proof that a marriage was void or has been annulled should consist of: (a... marriage void, together with such other evidence as may be required for a determination. (b) Annulled....

  6. Multiple void interaction of pipeline steel in triaxial stress fields

    Institute of Scientific and Technical Information of China (English)

    Bao-wen QIU; Ze-xi YUAN; Gui-feng ZHOU

    2008-01-01

    Three-dimensional unit cell models were developed to study the damage induced by void growth in ductile materials. Special emphasis is given to the influence of the void shape and random spatial void arrangements. The periodical void arrays of body cen-tered cubic are investigated by analyzing representative unit cells. The isotropic behavior of the matrix material is modeled using v. Mises plasticity. The cell models are analyzed by the large strain finite element method under monotonic loading while keeping the constant stress triaxiality. Results showed that when void density increased, effects of void aspects on void growth gradu-ally diminished.

  7. Gendered mental disorders: masculine and feminine stereotypes about mental disorders and their relation to stigma.

    Science.gov (United States)

    Boysen, Guy; Ebersole, Ashley; Casner, Robert; Coston, Nykhala

    2014-01-01

    Research indicates that stereotypes can intersect. For example, the intersection of stereotypes about gender and mental disorders could result in perceptions of gendered mental disorders. In the current research, Studies 1 and 2 showed that people view specific disorders as being masculine or feminine. The masculine stereotype included antisocial personality disorder, addictions, and paraphilias. The feminine stereotype included eating disorders, histrionic personality disorder, body dysmorphia, and orgasmic disorder. In both studies, the perception of disorders as masculine was positively correlated with stigma. Study 3 showed that the positive correlation between masculinity and stigma also occurred when examining specific symptoms rather than full mental disorders. The findings provide further evidence for the intersection of stereotypes and indicate a novel factor in the understanding of stigma.

  8. Study of localization in a void-sheet under stress states near pure shear

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2015-01-01

    to the principal tensile stress. A number of previous investigations have shown that such imperfections can lead to plastic flow localization in a shear band and subsequently lead to void-sheet fracture inside the band. The present analyses confirm that the imperfection results in localization failure, even......-cracks. For the largest imperfection considered, i.e. a relatively large ratio of the void radius to void spacing, there is still a range of stress states in the vicinity of pure shear, where no localization is predicted, and for smaller imperfections this range is larger....

  9. Effect of void cluster on ductile failure evolution

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2016-01-01

    The behavior of a non-uniform void distribution in a ductile material is investigated by using a cell model analysis to study a material with a periodic pattern of void clusters. The special clusters considered consist of a number of uniformly spaced voids located along a plane perpendicular...... to the maximum principal tensile stress. A plane strain approximation is used, where the voids are parallel cylindrical holes. Clusters with different numbers of voids are compared with the growth of a single void, such that the total initial volume of the voids, and thus also the void volume fractions...... understanding, different transverse stresses on the unit cell are considered to see the influence of different levels of stress triaxiality. Also considered are different initial ratios of the void spacing to the void radius inside the clusters. And results are shown for different levels of strain hardening...

  10. Universal void density profiles from simulation and SDSS

    CERN Document Server

    Nadathur, S; Diego, J M; Iliev, I T; Gottlöber, S; Watson, W A; Yepes, G

    2014-01-01

    We discuss the universality and self-similarity of void density profiles, for voids in realistic mock luminous red galaxy (LRG) catalogues from the Jubilee simulation, as well as in void catalogues constructed from the SDSS LRG and Main Galaxy samples. Voids are identified using a modified version of the ZOBOV watershed transform algorithm, with additional selection cuts. We find that voids in simulation are self-similar, meaning that their average rescaled profile does not depend on the void size, or -- within the range of the simulated catalogue -- on the redshift. Comparison of the profiles obtained from simulated and real voids shows an excellent match. The profiles of real voids also show a universal behaviour over a wide range of galaxy luminosities, number densities and redshifts. This points to a fundamental property of the voids found by the watershed algorithm, which can be exploited in future studies of voids.

  11. Universal void density profiles from simulation and SDSS

    Science.gov (United States)

    Nadathur, S.; Hotchkiss, S.; Diego, J. M.; Iliev, I. T.; Gottlöber, S.; Watson, W. A.; Yepes, G.

    2016-10-01

    We discuss the universality and self-similarity of void density profiles, for voids in realistic mock luminous red galaxy (LRG) catalogues from the Jubilee simulation, as well as in void catalogues constructed from the SDSS LRG and Main Galaxy samples. Voids are identified using a modified version of the ZOBOV watershed transform algorithm, with additional selection cuts. We find that voids in simulation are self-similar, meaning that their average rescaled profile does not depend on the void size, or - within the range of the simulated catalogue - on the redshift. Comparison of the profiles obtained from simulated and real voids shows an excellent match. The profiles of real voids also show a universal behaviour over a wide range of galaxy luminosities, number densities and redshifts. This points to a fundamental property of the voids found by the watershed algorithm, which can be exploited in future studies of voids.

  12. Post-void residual urine under 150 ml does not exclude voiding dysfunction in women

    DEFF Research Database (Denmark)

    Khayyami, Yasmine; Klarskov, Niels; Lose, Gunnar

    2016-01-01

    INTRODUCTION AND HYPOTHESIS: It has been claimed that post-void residual urine (PVR) below 150 ml rules out voiding dysfunction in women with stress urinary incontinence (SUI) and provides license to perform sling surgery. The cut-off of 150 ml seems arbitrary, not evidence-based, and so we sough...

  13. [Obscene telephone calls--relations to paraphilias, paraphilia related disorders and stalking].

    Science.gov (United States)

    Briken, Peer; Hill, Andreas; Nika, Evangelia; Berner, Wolfgang

    2005-09-01

    Little is known about the aetiology, course and therapy of obscene telephone calls as a paraphilic behaviour. Overlaps to other paraphilias like voyeurism, paraphilia related disorders and the concept of stalking are reported in the literature. In case reports we describe the paraphilic development and course with a focus on the relationship to the victim. We discuss this on the background of different concepts regarding risk assessment and therapy.

  14. I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review

    Directory of Open Access Journals (Sweden)

    Eun Joo Chung

    2015-05-01

    Full Text Available Lewy body-related disorders are characterized by the presence of Lewy bodies and Lewy neurites, which have abnormal aggregations of α-synuclein in the nigral and extranigral areas, including in the heart. 123I-metaiodobenzylguanidine (MIBG scintigraphy is a well-known tool to evaluate cardiac sympathetic denervation in the Lewy body-related disorders. MIBG scintigraphy showed low uptake of MIBG in the Lewy body-related disorders, including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and rapid eye movement sleep behavior disorder. This review summarizes previous results on the diagnostic applications of MIBG scintigraphy in Lewy body-related disorders.

  15. Assisted reproductive technology (ART) treatment in women with schizophrenia or related psychotic disorder

    DEFF Research Database (Denmark)

    Ebdrup, Ninna H; Assens, Maria; Hougaard, Charlotte O

    2014-01-01

    To determine the prevalence rate of women with a diagnosis of schizophrenia or related psychotic disorder in assisted reproductive technology (ART) treatment and to study these women's fertility treatment outcome in comparison to women with no psychotic disorders....

  16. Void damage model and service life prediction for solid high polymer

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Based on the analysis of three void damage variety models, this note presents ( i ) a method that regards the void content as a damage variation of the grain and ( ii ) a geometric model for micro-unit of void damage. Equations of the void damage variety containing void content are analyzed. This work is focused on the measurement of internal damage level and the damage variety estimation is directly related to the life predication in the practical engineering applications. Nowadays, the critical service life of the solid grain/polymers is usually presumed at domestic and international level. The strength or strain reduction of 20%or the stabilizer consumption of 50% is generally regarded as a critical storage life of the solid grain/polymers, and the service life is predicted by the extrapolation method on Anhenius formula. The applications, however, show that the above method is unreliable and has significant errors. With the aid of the discontiguous automatic measuring device of real time volume deformation and void content, the master curve of void damage variety, the storage service life and the surplus life of a solid rocket grain are obtained. Since the critical storage life has been measured, and the accuracy of the service life prediction has been greatly increased. It is a novel ideal and a break-through technique.

  17. Study on voids of epoxy matrix composites sandwich structure parts

    Science.gov (United States)

    He, Simin; Wen, Youyi; Yu, Wenjun; Liu, Hong; Yue, Cheng; Bao, Jing

    2017-03-01

    Void is the most common tiny defect of composite materials. Porosity is closely related to composite structure property. The voids forming behaviour in the composites sandwich structural parts with the carbon fiber reinforced epoxy resin skins was researched by adjusting the manufacturing process parameters. The composites laminate with different porosities were prepared with the different process parameter. The ultrasonic non-destructive measurement method for the porosity was developed and verified through microscopic examination. The analysis results show that compaction pressure during the manufacturing process had influence on the porosity in the laminate area. Increasing the compaction pressure and compaction time will reduce the porosity of the laminates. The bond-line between honeycomb core and carbon fiber reinforced epoxy resin skins were also analyzed through microscopic examination. The mechanical properties of sandwich structure composites were studied. The optimization process parameters and porosity ultrasonic measurement method for composites sandwich structure have been applied to the production of the composite parts.

  18. Relations between sensorimotor integration and speech disorders in Parkinson's disease.

    Science.gov (United States)

    Millian-Morell, Lymarie; López-Alburquerque, Tomás; Rodríguez-Rodríguez, Andrea; Gómez-Nieto, Ricardo; Carro, Juan; Meilán, Juan José G; Martínez-Sánchez, Francisco; Sancho, Consuelo; López, Dolores E

    2017-08-28

    Sensorimotor integration mechanisms can be affected by many factors, among which are those involving neuromuscular disorders. Parkinson's disease (PD) is characterized by well-known motor symptoms, among which lately have been included motor speech deficits. Measurement of the acoustic startle reflex (ASR) and its modulations (prepulse inhibition and prepulse facilitation, PPI and PPF respectively) represent a simple and quantifiable tool to assess sensorimotor function. However, it remains unknown whether measures of the PPI and PPF are associated with motor speech deficits in PD. A total of 88 subjects participated in this study, 52 diagnosed with PD and 36 control subjects. After obtaining written informed consent, participants were assessed with PPI at several interstimulus intervals, and PPF at 1000 ms using the SRH-Lab system (San Diego, CA). Percentage of change in the amplitude and latency of the ASR was analyzed between groups. Voice recordings were register of a specific text given to the subjects with a professional recorder and temporal patterns of speech were analyzed. Statistical analyses conducted in this study showed differences in PPI and PPF in subjects with PD compared to controls. In addition, discriminative parameters of voice abnormalities were observed in PD subjects related to control subjects showing a reduction in phonation time, vowel pulses, breaks, breakage and voice speech periods. PD presents a disruption in sensorimotor filter mechanisms and speech disorders, and there is a relationship between these alterations. The correlation between the PPI and PPF with an alteration of the voice in PD subjects contributes toward understanding mechanism underlying the neurophysiological alterations in both processes. Overall, easy and non-invasive tests such as PPI, PPF together with voice analysis may be useful to identify early stages of PD. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  19. VOID GROWTH AND CAVITATION IN NONLINEAR VISCOELASTIC SOLIDS

    Institute of Scientific and Technical Information of China (English)

    张赟; 黄筑平

    2003-01-01

    This paper discusses the growth of a pre-existing void in a nonlinear viscoelastic material subjected to remote hydrostatic tensions with different loading rates. The constitutive relation of this viscoelastic material is the one recently proposed by the present authors, which may be considered as a generalization of the non-Gaussian statistical theory in rubber elasticity. As the first order approximation, the above constitutive relation can be reduced to the "neo-Hookean" type viscoelastic one.Investigations of the influences of the material viscosity and the loading rate on the void growth, or on the cavitation are carried out. It is found that: (1) for generalized "inverse Langevin approximation"nonlinear viscoelastic materials, the cavitation limit does not exist, but there is a certain (remote)stress level at which the void will grow rapidly; (2) for generalized "Gaussian statistics" (neo-Hookean type) viscoelastic materials, the cavitation limit exists, and is an increasing function of the loading rate.The present discussions may be of importance in understanding the material failure process under high triaxial stress.

  20. Are diabetic patients being screened for sleep related breathing disorder?

    Institute of Scientific and Technical Information of China (English)

    Salim; Surani

    2013-01-01

    Prevalence of both diabetes mellitus and obstructive sleep apnea(OSA)is high among general population.Both of these conditions are associated with significant morbidity.OSA affects approximately 25%of men and 9%of women,and its prevalence is even higher among obese,Hispanics,African American and diabetic patients.Diabetes on the other hand besides having high prevalence in general population has even higher prevalence among ethnic populations as Hispanics and African American.Despite the availability of several simple screening tools for OSA,as Berlin questionnaire,STOP-BANG questionnaire,NAMES Criteria,the utility for screening of OSA among the diabetic population remains marginal.This in turn can lead to significant morbidity and complications related to OSA as well as worsening of diabetes mellitus and increase in diabetic complications due to untreated sleep related breathing disorder.It is therefore imperative for the primary care giver to screen for OSA among the diabetic population as a part of their routine evaluation to prevent worsening of diabetes,and its cardiovascular,renal,ophthalmologic and neurological complications.

  1. Quality of Smartphone Apps Related to Panic Disorder.

    Science.gov (United States)

    Van Singer, Mathias; Chatton, Anne; Khazaal, Yasser

    2015-01-01

    Quality of smartphone apps related to panic: smartphone apps have a growing role in health care. This study assessed the quality of English-language apps for panic disorder (PD) and compared paid and free apps. Keywords related to PD were entered into the Google Play Store search engine. Apps were assessed using the following quality indicators: accountability, interactivity, self-help score (the potential of smartphone apps to help users in daily life), and evidence-based content quality. The Brief DISCERN score and the criteria of the "Health on the Net" label were also used as content quality indicators as well as the number of downloads. Of 247 apps identified, 52 met all inclusion criteria. The content quality and self-help scores of these PD apps were poor. None of the assessed indicators were associated with payment status or number of downloads. Multiple linear regressions showed that the Brief DISCERN score significantly predicted the content quality and self-help scores. Poor content quality and self-help scores of PD smartphone apps highlight the gap between their technological potential and the overall quality of available products.

  2. Pycnogenol® in Metabolic Syndrome and Related Disorders.

    Science.gov (United States)

    Gulati, Om P

    2015-07-01

    The present review provides an update of the biological actions of Pycnogenol® in the treatment of metabolic syndrome and related disorders such as obesity, dyslipidaemia, diabetes and hypertension. Pycnogenol® is a French maritime pine bark extract produced from the outer bark of Pinus pinaster Ait. Subsp. atlantica. Its strong antioxidant, antiinflammatory, endothelium-dependent vasodilator activity, and also its anti-thrombotic effects make it appropriate for targeting the multifaceted pathophysiology of metabolic syndrome. Clinical studies have shown that it can reduce blood glucose levels in people with diabetes, blood pressure in mild to moderate hypertensive patients, and waist circumference, and improve lipid profile, renal and endothelial functions in metabolic syndrome. This review highlights the pathophysiology of metabolic syndrome and related clinical research findings on the safety and efficacy of Pycnogenol®. The results of clinical research studies performed with Pycnogenol® are discussed using an evidence-based, target-oriented approach following the pathophysiology of individual components as well as in metabolic syndrome overall.

  3. Void coalescence within periodic clusters of particles

    Science.gov (United States)

    Thomson, C. I. A.; Worswick, M. J.; Pilkey, A. K.; Lloyd, D. J.

    2003-01-01

    The effect of particle clustering on void damage rates in a ductile material under triaxial loading conditions is examined using three-dimensional finite element analysis. An infinite material containing a regular distribution of clustered particles is modelled using a unit cell approach. Three discrete particles are introduced into each unit cell while a secondary population of small particles within the surrounding matrix is represented using the Gurson-Tvergaard-Needleman (GTN) constitutive equations. Deformation strain states characteristic of sheet metal forming are considered; that is, deep drawing, plane strain and biaxial stretching. Uniaxial tensile stress states with varying levels of superimposed hydrostatic tension are also examined. The orientation of a particle cluster with respect to the direction of major principal loading is shown to significantly influence failure strains. Coalescence of voids within a first-order particle cluster (consisting of three particles) is a stable event while collapse of inter-cluster ligaments leads to imminent material collapse through void-sheeting.

  4. Effectiveness of tolterodine in nonneurogenic voiding dysfunction.

    Science.gov (United States)

    Babu, Ramesh

    2006-11-01

    The efficacy of tolterodine was analysed in children with non-neurogenic voiding dysfunction, using dysfunctional voiding symptom score (DVSS). Of 44 patients (mean age 9.3 yrs; M:F = 25:19), 36 received long acting tolterodine tartrate at a dose of 2mg OD and 8 at a dose of 4mg OD. The mean (SD) DVSS before and after the treatment was 17.1 (2.8) and 12.0 (2.4). There was a significant improvement in the mean DVSS score at the end of the treatment (Students t test P tolterodine is effective in children with voiding dysfunction. The single daily dose has good compliance and minimal side effect profile.

  5. Probing cosmology and gravity with redshift-space distortions around voids

    CERN Document Server

    Hamaus, Nico; Lavaux, Guilhem; Wandelt, Benjamin D

    2015-01-01

    Cosmic voids in the large-scale structure of the Universe affect the peculiar motions of objects in their vicinity. Although these motions are difficult to observe directly, the clustering pattern of their surrounding tracers in redshift space is influenced in a unique way. This allows to investigate the interplay between densities and velocities around voids, which is solely dictated by the laws of gravity. With the help of N-body simulations and derived mock-galaxy catalogs we calculate the average density fluctuations inside and outside voids identified with a watershed algorithm in redshift space and compare the results with the expectation from general relativity and the LCDM model of cosmology. We find that simple linear-theory predictions work remarkably well in describing the dynamics of voids even on relatively small scales. Adopting a Bayesian inference framework, we determine the full posterior probability distribution of our model parameters and forecast the achievable accuracy on measurements of ...

  6. Conclusive evidence of abrupt coagulation inside the void during cyclic nanoparticle formation in reactive plasma

    Science.gov (United States)

    van de Wetering, F. M. J. H.; Nijdam, S.; Beckers, J.

    2016-07-01

    In this letter, we present scanning electron microscopy (SEM) results that confirm in a direct way our earlier explanation of an abrupt coagulation event as the cause for the void hiccup. In a recent paper, we reported on the fast and interrupted expansion of voids in a reactive dusty argon-acetylene plasma. The voids appeared one after the other, each showing a peculiar, though reproducible, behavior of successive periods of fast expansion, abrupt contraction, and continued expansion. The abrupt contraction was termed "hiccup" and was related to collective coagulation of a new generation of nanoparticles growing in the void using relatively indirect methods: electron density measurements and optical emission spectroscopy. In this letter, we present conclusive evidence using SEM of particles collected at different moments in time spanning several growth cycles, which enables us to follow the nanoparticle formation process in great detail.

  7. A variational constitutive model for the distribution and interactions of multi-sized voids

    KAUST Repository

    Liu, Jinxing

    2013-07-29

    The evolution of defects or voids, generally recognized as the basic failure mechanism in most metals and alloys, has been intensively studied. Most investigations have been limited to spatially periodic cases with non-random distributions of the radii of the voids. In this study, we use a new form of the incompressibility of the matrix to propose the formula for the volumetric plastic energy of a void inside a porous medium. As a consequence, we are able to account for the weakening effect of the surrounding voids and to propose a general model for the distribution and interactions of multi-sized voids. We found that the single parameter in classical Gurson-type models, namely void volume fraction is not sufficient for the model. The relative growth rates of voids of different sizes, which can in principle be obtained through physical or numerical experiments, are required. To demonstrate the feasibility of the model, we analyze two cases. The first case represents exactly the same assumption hidden in the classical Gurson\\'s model, while the second embodies the competitive mechanism due to void size differences despite in a much simpler manner than the general case. Coalescence is implemented by allowing an accelerated void growth after an empirical critical porosity in a way that is the same as the Gurson-Tvergaard-Needleman model. The constitutive model presented here is validated through good agreements with experimental data. Its capacity for reproducing realistic failure patterns is shown by simulating a tensile test on a notched round bar. © 2013 The Author(s).

  8. Malposition of catheters during voiding cystourethrography

    Energy Technology Data Exchange (ETDEWEB)

    Rathaus, V.; Konen, O.; Shapiro, M. [Dept. of Diagnostic Imaging Sapir Medical Center, Kfar-Saba and Sackler Medical School, Tel Aviv University (Israel); Grunebaum, M. [Veteran Pediatric Radiologist, Kfar Saba (Israel)

    2001-04-01

    The aim of this study was to report catheter malposition during voiding cystourethrography. Eight hundred forty-three voiding cystourethrography (265 males and 578 females, aged 1 week to 12 years, mean age 2 years) were performed during a period of 4 years. The conventional standard procedure was applied. In 3 cases with passed history of urinary tract infection the catheter entered directly into the ureter. In all these cases the uretero-vesical reflux was present on the same side where the catheter entered. It appears that insertion of a catheter into the ureter is possible only in the presence of an anomaly or pathology at the vesicoureteric junction. (orig.)

  9. Plasticity size effects in voided crystals

    DEFF Research Database (Denmark)

    Hussein, M. I.; Borg, Ulrik; Niordson, Christian Frithiof;

    The shear and equi-biaxial straining responses of periodic voided single crystals are analysed using discrete dislocation plasticity and a continuum strain gradient crystal plasticity theory. In the discrete dislocation formulation the dislocations are all of edge character and are modelled as line...... predictions of the two formulations for all crystal types and void volume fractions considered when the material length scale in the non-local plasticity model chosen to be $0.325\\mu m$ (around ten times the slip plane spacing in the discrete dislocation models)....

  10. Musculoskeletal Disorders and Their Related Risk Factors Among Iranian Nurses

    Directory of Open Access Journals (Sweden)

    Taghinejad

    2016-02-01

    Full Text Available Background Work-related musculoskeletal disorders (MSDs are one of the most occupational problems among nurses and often cause many physical and psychological complications for nurses, and are a financial burden for health-care systems. Objectives The aim of this study was to determine the prevalence MSDs and their related risk factors among Iranian nurses. Patients and Methods This descriptive-correlational study included 240 hospital nurses, with a baccalaureate nursing degree, who worked at three public hospitals of the Ilam province of Iran. Data were collected through a validated self-administered questionnaire. Finally, 156 questionnaires were returned (response rate: 65% and 135 questionnaires qualified for subsequent analysis. The data were analyzed using the SPSS version 15.0 software. Descriptive and inferential statistics (logistic regression were used. Results Overall, 97 (71.9% hospital nurses experienced MSDs in at least one anatomical site within the last year. Low back pain was the most prevalent MSDs (40% and hip and thigh were the least (11.1% frequent sites. Most of the nurses with MSDs worked at surgery wards (17.8%, emergency (15.6% and intensive care units (12.6%. Pain (48.1% and cramps (31.9% were the most frequent symptoms of MSDs and loss of limbs control (5.9% was the least frequent symptom. Bend or twist at waist for performing nursing procedures, patient transfer from and to beds, working with the hands higher than shoulder height and changing position of patients in beds were the most frequent occupational factors that influenced MSDs. Increased age, weight, height, body mass index (BMI and gender had no significant association with MSDs. However, being single and involved in any kinds of physical activity were significantly associated with the prevalence of MSDs (P < 0.05. Conclusions The study findings indicated high prevalence of worked-related MSDs among Iranian hospital nurses. Accordingly, appropriate policies

  11. The relation between anger management style, mood and somatic symptoms in anxiety disorders and somatoform disorders.

    Science.gov (United States)

    Koh, Kyung Bong; Kim, Dong Kee; Kim, Shin Young; Park, Joong Kyu; Han, Mooyoung

    2008-09-30

    The objective of this study was to examine the relationship between anger management style, depression, anxiety and somatic symptoms in anxiety disorder and somatoform disorder patients. The subjects comprised 71 patients with anxiety disorders and 47 with somatoform disorders. The level of anger expression or anger suppression was assessed by the Anger Expression Scale, the severity of anxiety and depression by the Symptom Checklist-90-Revised (SCL-90-R) anxiety and depression subscales, and the severity of somatic symptoms by the Somatization Rating Scale and the SCL-90-R somatization subscale. The results of path analyses showed that anger suppression had only an indirect effect on somatic symptoms through depression and anxiety in each of the disorders. In addition, only anxiety had a direct effect on somatic symptoms in anxiety disorder patients, whereas both anxiety and depression had direct effects on somatic symptoms in somatoform disorder patients. However, the anxiety disorder group showed a significant negative correlation between anger expression and anger suppression in the path from anger-out to anger-in to depression to anxiety to somatic symptoms, unlike the somatoform disorder group. The results suggest that anger suppression, but not anger expression, is associated with mood, i.e. depression and anxiety, and somatic symptoms characterize anxiety disorder and somatoform disorder patients. Anxiety is likely to be an important source of somatic symptoms in anxiety disorders, whereas both anxiety and depression are likely to be important sources of somatic symptoms in somatoform disorders. In addition, anger suppression preceded by inhibited anger expression is associated with anxiety and somatic symptoms in anxiety disorders.

  12. Conceptual Relations between Anxiety Disorder and Fearful Temperament

    Science.gov (United States)

    Rapee, Ronald M.; Coplan, Robert J.

    2010-01-01

    Fearful temperaments have been identified as a major risk factor for anxiety disorders. However, descriptions of fearful temperament and several forms of anxiety disorder show strong similarities. This raises the question whether these terms may simply refer to different aspects of the same underlying construct. The current review examines…

  13. Conceptual Relations between Anxiety Disorder and Fearful Temperament

    Science.gov (United States)

    Rapee, Ronald M.; Coplan, Robert J.

    2010-01-01

    Fearful temperaments have been identified as a major risk factor for anxiety disorders. However, descriptions of fearful temperament and several forms of anxiety disorder show strong similarities. This raises the question whether these terms may simply refer to different aspects of the same underlying construct. The current review examines…

  14. Health Related Quality of Life in Children with Autism Spectrum Disorders: The Clinical and Demographic Related Factors in Turkey

    Science.gov (United States)

    Kose, Sezen; Erermis, Serpil; Ozturk, Onder; Ozbaran, Burcu; Demiral, Nagehan; Bildik, Tezan; Aydin, Cahide

    2013-01-01

    We aimed to investigate the Health Related Quality of Life and related clinical variables (HRQoL) of children with Autism Spectrum Disorders (ASD). We included 102 children with ASD (46 with autism, 38 with pervasive developmental disorder not otherwise specified (PDD-NOS) and 18 with Asperger's syndrome (AS)) and 39 typically developing children…

  15. Pulsed electrical breakdown of a void-filled dielectric

    Science.gov (United States)

    Anderson, R. A.; Lagasse, R. R.; Schroeder, J. L.

    2002-05-01

    We report breakdown strengths in a void-filled dielectric material, epoxy containing 48 vol % hollow glass microballoon filler, which is stressed with unipolar voltage pulses of the order of 10 μs duration. The microballoon voids had mean diameters of approximately 40 μm and contained SO2 gas at roughly 30% atmospheric pressure. This void-filled material displays good dielectric strength (of the order of 100 kV mm-1) under these short-pulse test conditions. Results from a variety of electrode geometries are reported, including arrangements in which the electric stress is highly nonuniform. Conventional breakdown criteria based on mean or peak electric stress do not account for these data. A statistics-based predictive breakdown model is developed, in which the dielectric is divided into independent, microballoon-sized "discharge cells" and the spontaneous discharge of a single cell is presumed to launch full breakdown of the composite. We obtain two empirical parameters, the mean and standard deviation of the spontaneous discharge field, by fitting breakdown data from two electrode geometries having roughly uniform fields but with greatly differing volumes of electrically stressed material. This model accounts for many aspects of our data, including the inherent statistical scatter and the dependence on the stressed volume, and it provides informative predictions with electrode geometries giving highly nonuniform fields. Issues related to computational spatial resolution and cutoff distance are also discussed.

  16. Confirmation of sublunarean voids and thin layering in mare deposits

    Science.gov (United States)

    Robinson, M. S.; Ashley, J. W.; Boyd, A. K.; Wagner, R. V.; Speyerer, E. J.; Ray Hawke, B.; Hiesinger, H.; van der Bogert, C. H.

    2012-08-01

    Typical flow thicknesses of lunar mare basalts were not well constrained in the past, because as craters and rilles age, downslope movement of loose material tends to mix and bury stratigraphy, obscuring the three dimensional nature of the maria. New Lunar Reconnaissance Orbiter Camera high resolution images unambiguously reveal thicknesses of mare basalt layers exposed in impact craters, rilles, and steep-walled pits. Pits up to one hundred meters deep present relatively unmodified, near-vertical sections of mare in three cases, and many young impact craters also expose well preserved sections of mare. Oblique views of each pit and many of these craters reveal multiple layers, 3 to 14 m thick, indicating that eruptions typically produced a series of ˜10 m thick flows (or flow lobes) rather than flows many tens to hundreds of meters thick. Additionally, these images unambiguously show that the floors of two pits extend beneath the mare surfaces, thus revealing sublunarean voids of unknown lateral extent. We also document the occurrence of pits that may be expressions of collapse into subsurface voids in non-mare impact melt deposits. These voids are compelling targets for future human and robotic exploration, with potential as temporary shelters, habitations, or geologic museums.

  17. Void Reactivity Coefficient Analysis during Void Fraction Changes in Innovative BWR Assemblies

    Directory of Open Access Journals (Sweden)

    Andrius Slavickas

    2015-01-01

    Full Text Available The study of the void reactivity variation in innovative BWR fuel assemblies is presented in this paper. The innovative assemblies are loaded with high enrichment fresh UO2 and MOX fuels. UO2 fuel enrichment is increased above existing design limitations for LWR fuels (>5%. MOX fuel enrichment with fissile Pu content is established to achieve the same burnup level as that of high enrichment UO2 fuel. For the numerical analysis, the TRITON functional module of SCALE 6.1 code with the 238-group ENDF/B-VI cross section data library was applied. The investigation of the void reactivity feedback is performed in the entire 0–100% void fraction range. Higher values of void reactivity coefficient for assembly loaded with MOX fuel are found in comparison with values for assembly loaded with UO2 fuel. Moreover, coefficient values for MOX fuel are positive over 75% void fraction. The variation of the void reactivity coefficient is explained by the results of the decomposition analysis based on four-factor formula and neutron absorption reactions for main isotopes. Additionally, the impact of the moderation enhancement on the void reactivity coefficient was investigated for the innovative assembly with MOX fuel.

  18. Cosmic Voids and Void Lensing in the Dark Energy Survey Science Verification Data

    CERN Document Server

    Sánchez, C; Kovacs, A; Jain, B; García-Bellido, J; Nadathur, S; Gruen, D; Hamaus, N; Huterer, D; Vielzeuf, P; Amara, A; Bonnett, C; DeRose, J; Hartley, W G; Jarvis, M; Lahav, O; Miquel, R; Rozo, E; Rykoff, E S; Sheldon, E; Wechsler, R H; Zuntz, J; Abbott, T M C; Abdalla, F B; Annis, J; Benoit-Lévy, A; Bernstein, G M; Bernstein, R A; Bertin, E; Brooks, D; Buckley-Geer, E; Rosell, A Carnero; Kind, M Carrasco; Carretero, J; Crocce, M; Cunha, C E; D'Andrea, C B; da Costa, L N; Desai, S; Diehl, H T; Dietrich, J P; Doel, P; Evrard, A E; Neto, A Fausti; Flaugher, B; Fosalba, P; Frieman, J; Gaztanaga, E; Gruendl, R A; Gutierrez, G; Honscheid, K; James, D J; Krause, E; Kuehn, K; Lima, M; Maia, M A G; Marshall, J L; Melchior, P; Plazas, A A; Reil, K; Romer, A K; Sanchez, E; Schubnell, M; Sevilla-Noarbe, I; Smith, R C; Soares-Santos, M; Sobreira, F; Suchyta, E; Tarle, G; Thomas, D; Walker, A R; Weller, J

    2016-01-01

    Galaxies and their dark matter halos populate a complicated filamentary network around large, nearly empty regions known as cosmic voids. Cosmic voids are usually identified in spectroscopic galaxy surveys, where 3D information about the large-scale structure of the Universe is available. Although an increasing amount of photometric data is being produced, its potential for void studies is limited since photometric redshifts induce line-of-sight position errors of $\\sim50$ Mpc/$h$ or more that can render many voids undetectable. In this paper we present a new void finder designed for photometric surveys, validate it using simulations, and apply it to the high-quality photo-$z$ redMaGiC galaxy sample of the Dark Energy Survey Science Verification (DES-SV) data. The algorithm works by projecting galaxies into 2D slices and finding voids in the smoothed 2D galaxy density field of the slice. Fixing the line-of-sight size of the slices to be at least twice the photo-$z$ scatter, the number of voids found in these ...

  19. Impulsivity-related traits and their relation to DSM-5 section II and III personality disorders.

    Science.gov (United States)

    Few, Lauren R; Lynam, Donald R; Miller, Joshua D

    2015-07-01

    Difficulties with impulse control are considered a core feature of personality disorders (PDs) as assessed by the Diagnostic and Statistical Manual of Mental Disorders (5th edition [DSM-5]; American Psychiatric Association, 2013). Despite this, there has been relatively little examination of the manner in which DSM-5 PDs are characterized by multidimensional models of impulsivity that parse this broad umbrella construct into smaller, more unidimensional constructs. Using the UPPS model and measure of impulsivity (Whiteside & Lynam, 2001), the relations between 4 impulsivity-related traits and interview-rated scores on both DSM-5 Section II and III PDs and PD traits were examined in a community sample of individuals currently receiving psychological or psychiatric care (N = 106). As expected, the UPPS traits manifested correlations with the new Section III trait model that were generally consistent with the assertion that this new DSM-5 trait model reflects a pathological variant of the Five-Factor Model (FFM; e.g., UPPS traits associated with FFM conscientiousness were most strongly related to DSM-5 disinhibition traits). Overall, the UPPS traits accounted best for variance in DSM-5 Section II and III Cluster B PDs, consistent with these PDs being characterized, in part, by emotionally and cognitively based forms of impulsivity.

  20. Prevention and management of work-related cardiovascular disorders

    Directory of Open Access Journals (Sweden)

    Akizumi Tsutsumi

    2015-02-01

    Full Text Available Cardiovascular disorders (CVDs constitute a major burden for health of working populations throughout the world with as much as 50% of all causes of death and at least 25% of work disability. There are some changes in CVD risk factors among occupational classes. This is mainly due to the new types of work-related causes of morbidity associated with the recent developments in global work life, particularly in the industrialized countries. Meanwhile, in the developing countries or those in transition (e.g., in Eastern Europe, CVD mortality is increasing due to major socioeconomic changes, the demographic transition and rapid industrialisation and urbanisation, all leading to growing challenges to cardiovascular health. Better control of known risk factors (i.e., smoking, obesity, physical inactivity, high cholesterol, high blood pressure, and high blood glucose is effective to prevent CVD incidence. But the expected improvement has not been achieved. The obstacles of achieving such impact are due to lack of awareness, lack of policies and their implementation into practice and shortage of infrastructures and human resources. These are needed for wide-scale and long-term programme implementation. Considering the WHO Global Strategy on Occupational Health for All, the WHO Global Action Plan on Workers’ Health, the WHO Programme on Prevention of Non-communicable Diseases and the ILO Decent Work agenda, the 6th ICOH International Conference on Work Environment and Cardiovascular Diseases adopted the Tokyo Declaration.

  1. [Positionpaper on Telemonitoring in Sleep-Related Breathing Disorders].

    Science.gov (United States)

    Randerath, W; Bögel, M; Franke, C; Hellmann, A; Jany, B; Nilius, G; Penzel, T; Voshaar, T; Wiater, A

    2017-02-01

    The use of telemonitoring in the care of patients with Sleep-related Breathing Disorders (SBD) can enhance medical support significantly. Telemonitoring aims at helping physicians to detect therapy problems early and thus improve patients' therapy adherence. Diagnostics and therapy decisions in the telemonitoring process nevertheless remain the responsibility of sleep specialists. The selection of data monitored, their evaluation and resulting consequences fall to the physician, who makes decisions and prescribes therapy in consultation with the patient. In light of professional legal and ethical requirements, it must be ensured that the extensive changes to the process flow in sleep medicine are designed in a way to guarantee high-quality patient care. In this position paper, the German Sleep Society, the German Respiratory Society, the Association of Pneumological Hospitals and the Federal Association of German Pneumologists comment on important aspects for implementation of telemonitoring for SRBD and describe the basic conditions required for its use. © Georg Thieme Verlag KG Stuttgart · New York.

  2. [Work-related mental and behaviour disorders in anesthesiologists].

    Science.gov (United States)

    Andrade, Gabriela Oliveira; Andrade Dantas, Rosa Amélia

    2015-01-01

    Anaesthesiology is a specialty whose specificity of the working process results in high levels of stress as an inevitable condition - a particularly worrying situation in the daily life of these professionals. This study, based on data from national and international literature, aims to discuss the basis of the occurrence of mental and behavioural disorders or of psychopathological injuries (psychological distress) related to working activity in anesthesiologists. A literature review was conducted, with papers selected from Medline and Lilacs databases, published between 2000 and 2012 in Portuguese, English and Spanish, and addressing the possible association between occupational hazards of the anaesthesiologist profession and mental health problems and psychic distress. Twenty-six publications were listed. Several aspects of the anesthesiologist's work are important points to better understand the relationship between mental health at work and working organization. Poor temporal structuring of work, conflictuous interpersonal relationships and poor control over the activity itself may be mentioned as illness enhancers. The working organization, when not appropriate, is an important occupational risk factor for the life and mental health of workers, mainly of professionals focused on the care of people. This paper focuses on anesthesiologists, who are constantly exposed to stressful and anxiogenic factors. Copyright © 2014 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

  3. Work-related mental and behaviour disorders in anesthesiologists.

    Science.gov (United States)

    Andrade, Gabriela Oliveira; Dantas, Rosa Amélia Andrade

    2015-01-01

    Anaesthesiology is a specialty whose specificity of the working process results in high levels of stress as an inevitable condition - a particularly worrying situation in the daily life of these professionals. This study, based on data from national and international literature, aims to discuss the basis of the occurrence of mental and behavioural disorders or of psychopathological injuries (psychological distress) related to working activity in anesthesiologists. A literature review was conducted, with papers selected from Medline and Lilacs databases, published between 2000 and 2012 in Portuguese, English and Spanish, and addressing the possible association between occupational hazards of the anaesthesiologist profession and mental health problems and psychic distress. Twenty-six publications were listed. Several aspects of the anesthesiologist's work are important points to better understand the relationship between mental health at work and working organization. Poor temporal structuring of work, conflictuous interpersonal relationships and poor control over the activity itself may be mentioned as illness enhancers. The working organization, when not appropriate, is an important occupational risk factor for the life and mental health of workers, mainly of professionals focused on the care of people. This paper focuses on anesthesiologists, who are constantly exposed to stressful and anxiogenic factors. Copyright © 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

  4. Protective role of melatonin in mitochondrial dysfunction and related disorders.

    Science.gov (United States)

    Paradies, Giuseppe; Paradies, Valeria; Ruggiero, Francesca M; Petrosillo, Giuseppe

    2015-06-01

    Mitochondria are the powerhouse of the eukaryotic cell through their use of oxidative phosphorylation to generate ATP. Mitochondrial dysfunction is considered an important contributing factor in a variety of physiopathological situations such as aging, heart ischemia/reperfusion injury, diabetes and several neurodegenerative and cardiovascular diseases, as well as in cell death. Increased formation of reactive oxygen species, altered respiratory chain complexes activity and opening of the mitochondrial permeability transition pore have been suggested as possible factors responsible for impaired mitochondrial function. Therefore, preventing mitochondrial dysfunction could be an effective therapeutic strategy against cellular degenerative processes. Cardiolipin is a unique phospholipid located at the level of inner mitochondrial membrane where it plays an important role in mitochondrial bioenergetics, as well as in cell death. Cardiolipin abnormalities have been associated with mitochondrial dysfunction in a variety of pathological conditions and aging. Melatonin, the major secretory product of the pineal gland, is a well-known antioxidant agent and thus an effective protector of mitochondrial bioenergetic function. Melatonin was reported to prevent mitochondrial dysfunction from oxidative damage by preserving cardiolipin integrity, and this may explain, at least in part, the beneficial effect of this compound in mitochondrial physiopathology. In this article, mechanisms through which melatonin exerts its protective role in mitochondrial dysfunction and related disorders are reviewed.

  5. Quality of smartphone apps related to panic disorder.

    Directory of Open Access Journals (Sweden)

    mathias eVan-Singer

    2015-07-01

    Full Text Available Smartphone apps have a growing role in health care. This study assessed the quality of English-language apps for panic disorder (PD and compared paid and free apps. Keywords related to PD were entered into the Google Play Store search engine. Apps were assessed using the following quality indicators: accountability, interactivity, self-help score (the potential of smartphone apps to help users in daily life, and evidence-based content quality. The Brief DISCERN score and the criteria of the Health on the Net label were also used as content quality indicators as well as the number of downloads. Of 247 apps identified, 52 met all inclusion criteria. The content quality and self-help scores of these PD apps were poor. None of the assessed indicators were associated with payment status or number of downloads. Multiple linear regressions showed that the Brief DISCERN score significantly predicted content quality and self-help scores. Poor content quality and self-help scores of PD smartphone apps highlight the gap between their technological potential and the overall quality of available products

  6. Work-related health disorders among Saudi computer users.

    Science.gov (United States)

    Jomoah, Ibrahim M

    2014-01-01

    The present study was conducted to investigate the prevalence of musculoskeletal disorders and eye and vision complaints among the computer users of King Abdulaziz University (KAU), Saudi Arabian Airlines (SAUDIA), and Saudi Telecom Company (STC). Stratified random samples of the work stations and operators at each of the studied institutions were selected and the ergonomics of the work stations were assessed and the operators' health complaints were investigated. The average ergonomic score of the studied work station at STC, KAU, and SAUDIA was 81.5%, 73.3%, and 70.3, respectively. Most of the examined operators use computers daily for ≤ 7 hours, yet they had some average incidences of general complaints (e.g., headache, body fatigue, and lack of concentration) and relatively high level of incidences of eye and vision complaints and musculoskeletal complaints. The incidences of the complaints have been found to increase with the (a) decrease in work station ergonomic score, (b) progress of age and duration of employment, (c) smoking, (d) use of computers, (e) lack of work satisfaction, and (f) history of operators' previous ailments. It has been recommended to improve the ergonomics of the work stations, set up training programs, and conduct preplacement and periodical examinations for operators.

  7. Work-Related Health Disorders among Saudi Computer Users

    Directory of Open Access Journals (Sweden)

    Ibrahim M. Jomoah

    2014-01-01

    Full Text Available The present study was conducted to investigate the prevalence of musculoskeletal disorders and eye and vision complaints among the computer users of King Abdulaziz University (KAU, Saudi Arabian Airlines (SAUDIA, and Saudi Telecom Company (STC. Stratified random samples of the work stations and operators at each of the studied institutions were selected and the ergonomics of the work stations were assessed and the operators’ health complaints were investigated. The average ergonomic score of the studied work station at STC, KAU, and SAUDIA was 81.5%, 73.3%, and 70.3, respectively. Most of the examined operators use computers daily for ≤ 7 hours, yet they had some average incidences of general complaints (e.g., headache, body fatigue, and lack of concentration and relatively high level of incidences of eye and vision complaints and musculoskeletal complaints. The incidences of the complaints have been found to increase with the (a decrease in work station ergonomic score, (b progress of age and duration of employment, (c smoking, (d use of computers, (e lack of work satisfaction, and (f history of operators’ previous ailments. It has been recommended to improve the ergonomics of the work stations, set up training programs, and conduct preplacement and periodical examinations for operators.

  8. Work-Related Health Disorders among Saudi Computer Users

    Science.gov (United States)

    Jomoah, Ibrahim M.

    2014-01-01

    The present study was conducted to investigate the prevalence of musculoskeletal disorders and eye and vision complaints among the computer users of King Abdulaziz University (KAU), Saudi Arabian Airlines (SAUDIA), and Saudi Telecom Company (STC). Stratified random samples of the work stations and operators at each of the studied institutions were selected and the ergonomics of the work stations were assessed and the operators' health complaints were investigated. The average ergonomic score of the studied work station at STC, KAU, and SAUDIA was 81.5%, 73.3%, and 70.3, respectively. Most of the examined operators use computers daily for ≤ 7 hours, yet they had some average incidences of general complaints (e.g., headache, body fatigue, and lack of concentration) and relatively high level of incidences of eye and vision complaints and musculoskeletal complaints. The incidences of the complaints have been found to increase with the (a) decrease in work station ergonomic score, (b) progress of age and duration of employment, (c) smoking, (d) use of computers, (e) lack of work satisfaction, and (f) history of operators' previous ailments. It has been recommended to improve the ergonomics of the work stations, set up training programs, and conduct preplacement and periodical examinations for operators. PMID:25383379

  9. Parental and Child Characteristics Related to Early-Onset Disordered Eating

    DEFF Research Database (Denmark)

    Larsen, Pernille Stemann; Strandberg-Larsen, Katrine; Micali, Nadia

    2015-01-01

    characteristics related to early-onset disordered eating. Systematic searches were conducted in PubMED/MEDLINE, EMBASE, and PsycInfo using the following search terms: eating disorder, disordered eating, problem eating, anorexia nervosa, bulimia nervosa, binge eating, child, preadolescent, and early onset. Studies...

  10. HIV-related movement disorders: epidemiology, pathogenesis and management.

    Science.gov (United States)

    Cardoso, Francisco

    2002-01-01

    Clinically relevant movement disorders are identified in 3% of patients with HIV infection seen at tertiary referral centres. In the same setting, prospective follow-up shows that 50% of patients with AIDS develop tremor, parkinsonism or other extrapyramidal features. Hemiballism-hemichorea and tremor are the most common hyperkinesias seen in patients who are HIV positive, but other movement disorders diagnosed in these patients include dystonia, chorea, myoclonus, tics, paroxysmal dyskinesias and parkinsonism. Patients with movement disorders usually present with other clinical features such as peripheral neuropathy, seizures, myelopathy and dementia. In the vast majority of patients, hyperkinesias result from lesions caused by opportunistic infections, particularly toxoplasmosis, which damage the basal ganglia connections. On the other hand, parkinsonism and tremor can result from dopaminergic dysfunction resulting from HIV itself or the use of antidopaminergic drugs. The management of patients who are HIV positive who present with movement disorders involves recognition and treatment of opportunistic infections, symptomatic treatment of the movement disorder and the use of highly active antiretroviral therapy (HAART). The most effective treatment of cerebral toxoplasmosis in patients with HIV infection is the combination of sulfadiazine and pyrimethamine. Symptomatic treatment of the movement disorder is often disappointing: hemiballism improves with antipsychotics, but tremor, parkinsonism and other phenomena usually fail to respond to available therapies. Preliminary data suggest that HAART may be helpful in the symptomatic control as well as prevention of movement disorders in patients who are HIV positive.

  11. Study of Void Probability Scaling of Pions in Ultrarelativistic Nuclear Collision in Fractal Scenario

    CERN Document Server

    Bhaduri, Susmita

    2016-01-01

    Various existing works on multiplicity fluctuation probed about the dynamics of particle production process and eventually signature of phase transition in ultrarelativistic nuclear collision. Fluctuation of spatial pattern has also been analyzed in terms of the scaling behavior of voids. However, analysis of the scaling behavior of the void from fractal scenario has not been explored yet. This work attempts to study the fractality of void probability distribution from a radically different and rigorous method called Visibility Graph analysis, analyzing the data of 32-S-AgBr(200 GeV) interaction. The analysis reveals strong scaling behavior of void probability distribution in all pseurorapidity region. The scaling exponent-PSVG(Power of the Scale-freeness in Visibility Graph), a quantitative parameter related to Hurst exponent, is strongly dependent on rapidity window.

  12. Measurement of post-void residual urine

    NARCIS (Netherlands)

    Asimakopoulos, Anastasios D.; De Nunzio, Cosimo; Kocjancic, Ervin; Tubaro, Andrea; Rosier, Peter F.; Finazzi-Agrò, Enrico

    2016-01-01

    Aims To present the teaching module "Measurement of Post-void residual urine." Methods This module has been prepared by a Working Group of the ICS Urodynamics Committee. The methodology used included comprehensive literature review, consensus formation by the members of the Working Group, and review

  13. Void fraction instrument acceptance test procedure

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, K.L.

    1994-09-15

    This acceptance test procedure (ATP) was written to test the void fraction instrument (VFI) and verify that the unit is ready for field service. The procedure verifies that the mechanical and electrical features (not specifically addressed in the software ATP) and software alarms are operating as designed.

  14. Halo abundances and shear in void models

    DEFF Research Database (Denmark)

    Alonso, David; García-Bellido, Juan; Haugbølle, Troels

    2012-01-01

    We study the non-linear gravitational collapse of dark matter into halos through numerical N-body simulations of Lemaitre-Tolman-Bondi void models. We extend the halo mass function formalism to these models in a consistent way. This extension not only compares well with the simulated data at all ...

  15. Halo abundances and shear in void models

    DEFF Research Database (Denmark)

    Alonso, David; García-Bellido, Juan; Haugbølle, Troels;

    2012-01-01

    We study the non-linear gravitational collapse of dark matter into halos through numerical N-body simulations of Lemaitre-Tolman-Bondi void models. We extend the halo mass function formalism to these models in a consistent way. This extension not only compares well with the simulated data at all...

  16. Void fraction instrument acceptance test procedure

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, K.L.

    1994-09-15

    This acceptance test procedure (ATP) was written to test the void fraction instrument (VFI) and verify that the unit is ready for field service. The procedure verifies that the mechanical and electrical features (not specifically addressed in the software ATP) and software alarms are operating as designed.

  17. "Dark energy" in the Local Void

    Science.gov (United States)

    Villata, M.

    2012-05-01

    The unexpected discovery of the accelerated cosmic expansion in 1998 has filled the Universe with the embarrassing presence of an unidentified "dark energy", or cosmological constant, devoid of any physical meaning. While this standard cosmology seems to work well at the global level, improved knowledge of the kinematics and other properties of our extragalactic neighborhood indicates the need for a better theory. We investigate whether the recently suggested repulsive-gravity scenario can account for some of the features that are unexplained by the standard model. Through simple dynamical considerations, we find that the Local Void could host an amount of antimatter (˜5×1015 M ⊙) roughly equivalent to the mass of a typical supercluster, thus restoring the matter-antimatter symmetry. The antigravity field produced by this "dark repulsor" can explain the anomalous motion of the Local Sheet away from the Local Void, as well as several other properties of nearby galaxies that seem to require void evacuation and structure formation much faster than expected from the standard model. At the global cosmological level, gravitational repulsion from antimatter hidden in voids can provide more than enough potential energy to drive both the cosmic expansion and its acceleration, with no need for an initial "explosion" and dark energy. Moreover, the discrete distribution of these dark repulsors, in contrast to the uniformly permeating dark energy, can also explain dark flows and other recently observed excessive inhomogeneities and anisotropies of the Universe.

  18. Partial discharges in ellipsoidal and spheroidal voids

    DEFF Research Database (Denmark)

    Crichton, George C; Karlsson, P. W.; Pedersen, Aage

    1989-01-01

    Transients associated with partial discharges in voids can be described in terms of the charges induced on the terminal electrodes of the system. The relationship between the induced charge and the properties which are usually measured is discussed. The method is illustrated by applying it to a s...

  19. Atomistic modeling of shock-induced void collapse in copper

    Energy Technology Data Exchange (ETDEWEB)

    Davila, L P; Erhart, P; Bringa, E M; Meyers, M A; Lubarda, V A; Schneider, M S; Becker, R; Kumar, M

    2005-03-09

    Nonequilibrium molecular dynamics (MD) simulations show that shock-induced void collapse in copper occurs by emission of shear loops. These loops carry away the vacancies which comprise the void. The growth of the loops continues even after they collide and form sessile junctions, creating a hardened region around the collapsing void. The scenario seen in our simulations differs from current models that assume that prismatic loop emission is responsible for void collapse. We propose a new dislocation-based model that gives excellent agreement with the stress threshold found in the MD simulations for void collapse as a function of void radius.

  20. DSM-5 reviewed from different angles: goal attainment, rationality, use of evidence, consequences—part 2: bipolar disorders, schizophrenia spectrum disorders, anxiety disorders, obsessive-compulsive disorders, trauma- and stressor-related disorders, personality disorders, substance-related and addictive disorders, neurocognitive disorders.

    Science.gov (United States)

    Möller, Hans-Jürgen; Bandelow, Borwin; Bauer, Michael; Hampel, Harald; Herpertz, Sabine C; Soyka, Michael; Barnikol, Utako B; Lista, Simone; Severus, Emanuel; Maier, Wolfgang

    2015-03-01

    Part 1 of this paper discussed several more general aspects of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and offered a detailed, paradigmatic analysis of changes made to the chapter on depressive disorders. This second part focusses on several other disorders, including bipolar and schizophrenia spectrum disorders. The respective changes and their possible consequences are discussed under consideration of traditional psychiatric classification, particularly from the perspective of European traditions and on the basis of a PubMed search and review papers. The general conclusion is that even seemingly small changes such as the introduction of the mixed feature specifier can have far-reaching consequences. Contrary to the original plans, DSM-5 has not radically changed to become a primarily dimensional diagnostic system but has preserved the categorical system for most disorders. The ambivalence of the respective decision-making becomes apparent from the last minute decision to change the classification of personality disorders from dimensional back to categorical. The advantages and disadvantages of the different approaches are discussed in this context. In DSM-5, only the chapter on addictive disorders has a somewhat dimensional structure. Also in contrast to the original intentions, DSM-5 has not used a more neurobiological approach to disorders by including biological markers to increase the objectivity of psychiatric diagnoses. Even in the most advanced field in terms of biomarkers, the neurocognitive disorders, the primarily symptom-based, descriptive approach has been preserved and the well-known amyloid-related and other biomarkers are not included. This is because, even after so many years of biomarker research, the results are still not considered to be robust enough to use in clinical practice.

  1. Disordered Eating-Related Cognition and Psychological Flexibility as Predictors of Psychological Health among College Students

    Science.gov (United States)

    Masuda, Akihiko; Price, Matthew; Anderson, Page L.; Wendell, Johanna W.

    2010-01-01

    The present cross-sectional study investigated the relation among disordered eating-related cognition, psychological flexibility, and poor psychological outcomes among a nonclinical college sample. As predicted, conviction of disordered eating-related cognitions was positively associated with general psychological ill-health and emotional distress…

  2. Error-Related Negativity and Tic History in Pediatric Obsessive-Compulsive Disorder

    Science.gov (United States)

    Hanna, Gregory L.; Carrasco, Melisa; Harbin, Shannon M.; Nienhuis, Jenna K.; LaRosa, Christina E.; Chen, Poyu; Fitzgerald, Kate D.; Gehring, William J.

    2012-01-01

    Objective: The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response, which is often increased in patients with obsessive-compulsive disorder (OCD). However, the relation of the ERN to comorbid tic disorders has not been examined in patients with OCD. This study compared ERN amplitudes…

  3. Disordered Eating-Related Cognition and Psychological Flexibility as Predictors of Psychological Health among College Students

    Science.gov (United States)

    Masuda, Akihiko; Price, Matthew; Anderson, Page L.; Wendell, Johanna W.

    2010-01-01

    The present cross-sectional study investigated the relation among disordered eating-related cognition, psychological flexibility, and poor psychological outcomes among a nonclinical college sample. As predicted, conviction of disordered eating-related cognitions was positively associated with general psychological ill-health and emotional distress…

  4. Error-Related Negativity and Tic History in Pediatric Obsessive-Compulsive Disorder

    Science.gov (United States)

    Hanna, Gregory L.; Carrasco, Melisa; Harbin, Shannon M.; Nienhuis, Jenna K.; LaRosa, Christina E.; Chen, Poyu; Fitzgerald, Kate D.; Gehring, William J.

    2012-01-01

    Objective: The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response, which is often increased in patients with obsessive-compulsive disorder (OCD). However, the relation of the ERN to comorbid tic disorders has not been examined in patients with OCD. This study compared ERN amplitudes…

  5. Prevalence of depression, anxiety, adjustment disorders, and somatoform disorders in patients with age-related macular degeneration in Germany

    Science.gov (United States)

    Jacob, Louis; Spiess, Alexandra; Kostev, Karel

    2017-01-01

    Aims: The purpose of this study was to analyze the prevalence of depression, anxiety, adjustment disorders, and somatoform disorders in patients diagnosed with age-related macular degeneration (AMD) in Germany. Methods: This study included 7,580 patients between the ages of 40 and 90 diagnosed with AMD between January 2011 and December 2014 in 1,072 primary care practices (index date). The last follow-up was in July 2016. We also included 7,580 controls without AMD, which were matched (1:1) to the AMD cases by age, sex, type of health insurance (private or statutory), physician, and Charlson comorbidity score as a generic marker of comorbidity. The outcome of the study was the prevalence of depression, anxiety, adjustment disorders, and somatoform disorders recorded in the database between the index date and the end of follow-up. Results: The mean age among subjects was 75.7 years (SD=10.1 years), 34.0% were men, and 7.8% had private health insurance coverage. The Charlson comorbidity index was 2.0 (SD=1.8). Depression was the most frequent disease (33.7% in AMD patients versus 27.3% in controls), followed by somatoform disorders (19.6% and 16.7%), adjustment disorders (14.8% and 10.5%), and anxiety disorders (11.7% and 8.2%). Depression (OR=1.37, 95% CI: 1.27–1.47), anxiety (OR=1.50, 95% CI: 1.35–1.67), adjustment disorders (OR=1.50, 95% CI: 1.36–1.65), and somatoform disorders (OR=1.22, 95% CI: 1.12–1.32) were all positively associated with AMD. Conclusion: Overall, a significant association was found between AMD and depression, anxiety, adjustment disorders, and somatoform disorders.

  6. Relation between Amygdala Structure and Function in Adolescents with Bipolar Disorder

    Science.gov (United States)

    Kalmar, Jessica H.; Wang, Fei; Chepenik, Lara G.; Womer, Fay Y.; Jones, Monique M.; Pittman, Brian; Shah, Maulik P.; Martin, Andres; Constable, R. Todd; Blumberg, Hilary P.

    2009-01-01

    Adolescents with bipolar disorder showed decreased amygdala volume and increased amygdala response to emotional faces. Amygdala volume is inversely related to activation during emotional face processing.

  7. Relation between Amygdala Structure and Function in Adolescents with Bipolar Disorder

    Science.gov (United States)

    Kalmar, Jessica H.; Wang, Fei; Chepenik, Lara G.; Womer, Fay Y.; Jones, Monique M.; Pittman, Brian; Shah, Maulik P.; Martin, Andres; Constable, R. Todd; Blumberg, Hilary P.

    2009-01-01

    Adolescents with bipolar disorder showed decreased amygdala volume and increased amygdala response to emotional faces. Amygdala volume is inversely related to activation during emotional face processing.

  8. Clinical features and related factors to anxiety disorders in adolescents

    Institute of Scientific and Technical Information of China (English)

    杨帆

    2013-01-01

    Objective To explore the social and psychological risk factors to anxiety disorders in adolescents,and to screen protective factors and risk factors and establish the prediction model.Methods The Screen for Child Anxiety

  9. Recent advances in iron metabolism and related disorders.

    Science.gov (United States)

    Camaschella, Clara; Strati, Paolo

    2010-10-01

    Iron is essential for life, because it is indispensable for several biological reactions such as oxygen transport, DNA synthesis and cell proliferation, but is toxic if present in excess since it causes cellular damage through free radical formation. Either cellular or systemic iron regulation can be disrupted in disorders of iron metabolism. In the past few years, our understanding of iron metabolism and its regulation has dramatically changed. New disorders of iron metabolism have emerged and the role of iron has started to be recognized as a cofactor of other disorders. The study of genetic conditions such as hemochromatosis and iron-refractory-iron-deficiency anemia (IRIDA) has provided crucial insights into the molecular mechanisms controlling iron homeostasis. In the future, these advances may be exploited for a more effective treatment of both genetic and acquired iron disorders.

  10. Myasthenia gravis and related disorders: Pathology and molecular pathogenesis.

    Science.gov (United States)

    Ha, James C; Richman, David P

    2015-04-01

    Disorders affecting the presynaptic, synaptic, and postsynaptic portions of the neuromuscular junction arise from various mechanisms in children and adults, including acquired autoimmune or toxic processes as well as genetic mutations. Disorders include autoimmune myasthenia gravis associated with acetylcholine receptor, muscle specific kinase or Lrp4 antibodies, Lambert-Eaton myasthenic syndrome, nerve terminal hyperexcitability syndromes, Guillain Barré syndrome, botulism, organophosphate poisoning and a number of congenital myasthenic syndromes. This review focuses on the various molecular and pathophysiological mechanisms of these disorders, characterization of which has been crucial to the development of treatment strategies specific for each pathogenic mechanism. In the future, further understanding of the underlying processes may lead to more effective and targeted therapies of these disorders. This article is part of a Special Issue entitled: Neuromuscular Diseases: Pathology and Molecular Pathogenesis.

  11. Childhood trauma and childhood urbanicity in relation to psychotic disorder

    NARCIS (Netherlands)

    Frissen, Aleida; Lieverse, Ritsaert; Drukker, Marjan; van Winkel, Ruud; Delespaul, Philippe; Cahn, W

    2015-01-01

    BACKGROUND: Urban upbringing and childhood trauma are both associated with psychotic disorders. However, the association between childhood urbanicity and childhood trauma in psychosis is poorly understood. The urban environment could occasion a background of social adversity against which any effect

  12. Membranous Nephropathy Associated With Immunological Disorder-Related Liver Disease

    Science.gov (United States)

    Dauvergne, Maxime; Moktefi, Anissa; Rabant, Marion; Vigneau, Cécile; Kofman, Tomek; Burtey, Stephane; Corpechot, Christophe; Stehlé, Thomas; Desvaux, Dominique; Rioux-Leclercq, Nathalie; Rouvier, Philippe; Knebelmann, Bertrand; Boffa, Jean-Jacques; Frouget, Thierry; Daugas, Eric; Jablonski, Mathieu; Dahan, Karine; Brocheriou, Isabelle; Remy, Philippe; Grimbert, Philippe; Lang, Philippe; Chazouilleres, Oliver; Sahali, Dil; Audard, Vincent

    2015-01-01

    Abstract The association between membranous nephropathy (MN) and immunological disorder-related liver disease has not been extensively investigated, and the specific features of this uncommon association, if any, remain to be determined. We retrospectively identified 10 patients with this association. We aimed to describe the clinical, biological, and pathological characteristics of these patients and their therapeutic management. The possible involvement of the phospholipase A2 receptor (PLA2R) in these apparent secondary forms of MN was assessed by immunohistochemistry with renal and liver biopsy specimens. The mean delay between MN and liver disease diagnoses was 3.9 years and the interval between the diagnosis of the glomerular and liver diseases was <1.5 years in 5 patients. MN was associated with a broad spectrum of liver diseases including primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC). AIH whether isolated (n = 3) or associated with PBC (n = 2) or PSC (n = 2) was the most frequent autoimmune liver disease. Circulating PLA2R antibodies were detected in 4 out of 9 patients but the test was performed under specific immunosuppressive treatment in 3 out of 9 patients. Seven of the 9 patients with available renal tissue specimens displayed enhanced expression of PLA2R in glomeruli whereas PLA2R was not expressed in liver parenchyma from these patients or in normal liver tissue. The study of immunoglobulin (Ig) subclasses of deposits in glomeruli revealed that the most frequent pattern was the coexistence of IgG1 and IgG4 immune deposits with IgG4 predominating. Detection of PLA2R antibodies in glomeruli but not in liver parenchyma is a common finding in patients with MN associated with autoimmune liver disease, suggesting that these autoantibodies are not exclusively detected in idiopathic MN. PMID:26222864

  13. Failure by void coalescence in metallic materials containing primary and secondary voids subject to intense shearing

    DEFF Research Database (Denmark)

    Nielsen, Kim Lau; Tvergaard, Viggo

    2011-01-01

    , subject to shear dominated loading. To account for both length scales involved in this study, a continuum model that includes the softening effect of damage evolution in shear is used to represent the matrix material surrounding the primary voids. Here, a recently extended Gurson-type model is used, which......Failure under intense shearing at close to zero stress triaxiality is widely observed for ductile metallic materials, and is identified in experiments as smeared-out dimples on the fracture surface. Numerical cell-model studies of equal sized voids have revealed that the mechanism governing...... secondary damage that co-exists with or nucleation in the ligaments between larger voids that coalesce during intense shearing. A numerical cell-model study is carried out to gain a parametric understanding of the overall material response for different initial conditions of the two void populations...

  14. Competitiveness as a moderator of the relation between appearance-related factors and disordered eating behaviors.

    Science.gov (United States)

    Schleien, Jenna L; Bardone-Cone, Anna M

    2016-06-01

    The present study examined competitiveness as a moderator of the relationships between appearance-related factors (i.e., thin-ideal internalization, appearance contingent self-worth) and disordered eating behaviors (i.e., dieting, excessive exercise). Participants were 441 undergraduate females for cross-sectional analyses, with 237 also contributing data longitudinally, 1 year later. Results showed that, in a model including thin-ideal internalization and appearance contingent self-worth and their interactions with competitiveness, thin-ideal internalization (but not appearance contingent self-worth) interacted with competitiveness to identify concurrent levels of both dieting and excessive exercise. Individuals high in both thin-ideal internalization and competitiveness exhibited the highest levels of concurrent dieting and excessive exercise. After controlling for baseline levels of the dependent variables, neither appearance-related factor interacted with competitiveness to predict dieting or excessive exercise. These findings suggest that individuals who are both competitive and accept and strive to achieve the thin ideal may be at risk for disordered eating behaviors.

  15. Relational experiences of partnered Japanese immigrant women with affect disorders.

    Science.gov (United States)

    Kozuki, Yoriko; Kennedy, Michael G; Tsai, Jenny Hsin-Chun

    2006-03-01

    This paper reports the findings of a study that explored characteristics of relationships of Japanese immigrant women partnered both intraculturally and interculturally, and analysed the role of Japanese culture in these relationships. Immigration can cause shifts in interpersonal structures with partners. When there are large discrepancies in gender roles and communication styles between the original and host cultures, the psychological impact on both partners may be significant. However, currently no empirical data are available to support this assumption. Ten cases selected from the 68 medical records of Japanese-speaking women seen at a mental health clinic from September 2001 to September 2004 were analysed. All of the 10 women met DSM IV-TR criteria of major depressive disorder and were taking antidepressants. Half of the 10 women were in intimate intercultural partnered relationships and the remainder of the matched cases were in intracultural relationships at the time of treatment. The two cohorts were matched in age (36.2 and 43.2 years), length of stay in the United States of America (12 and 16.2 years), and length of treatment (1.2 and 1 years). The length of time of the sample in individual psychodynamic psychotherapy ranged from 20 to 317 hours, depending on the intensity of therapy. Inductive data analysis revealed two themes: (1) Lack of awareness of differences in culturally bound communication by Japanese women in intercultural partnerships; (2) Lack of individuality in Japanese women in intracultural partnerships. Neither group appeared to consider relational aspects of partnership, or to make efforts to improve direct communication with their partners. The influence of Japanese culture on gender role and communication styles functions contrary to the mainstream Western culture of the United States of America. In the future, interpersonal elements of cultural differences between host and original cultures in immigration should be considered in

  16. Probing disorder in isometric pyrochlore and related complex oxides

    Science.gov (United States)

    Shamblin, Jacob; Feygenson, Mikhail; Neuefeind, Joerg; Tracy, Cameron L.; Zhang, Fuxiang; Finkeldei, Sarah; Bosbach, Dirk; Zhou, Haidong; Ewing, Rodney C.; Lang, Maik

    2016-05-01

    There has been an increased focus on understanding the energetics of structures with unconventional ordering (for example, correlated disorder that is heterogeneous across different length scales). In particular, compounds with the isometric pyrochlore structure, A2B2O7, can adopt a disordered, isometric fluorite-type structure, (A, B)4O7, under extreme conditions. Despite the importance of the disordering process there exists only a limited understanding of the role of local ordering on the energy landscape. We have used neutron total scattering to show that disordered fluorite (induced intrinsically by composition/stoichiometry or at far-from-equilibrium conditions produced by high-energy radiation) consists of a local orthorhombic structural unit that is repeated by a pseudo-translational symmetry, such that orthorhombic and isometric arrays coexist at different length scales. We also show that inversion in isometric spinel occurs by a similar process. This insight provides a new basis for understanding order-to-disorder transformations important for applications such as plutonium immobilization, fast ion conduction, and thermal barrier coatings.

  17. Probing disorder in isometric pyrochlore and related complex oxides.

    Science.gov (United States)

    Shamblin, Jacob; Feygenson, Mikhail; Neuefeind, Joerg; Tracy, Cameron L; Zhang, Fuxiang; Finkeldei, Sarah; Bosbach, Dirk; Zhou, Haidong; Ewing, Rodney C; Lang, Maik

    2016-05-01

    There has been an increased focus on understanding the energetics of structures with unconventional ordering (for example, correlated disorder that is heterogeneous across different length scales). In particular, compounds with the isometric pyrochlore structure, A2B2O7, can adopt a disordered, isometric fluorite-type structure, (A, B)4O7, under extreme conditions. Despite the importance of the disordering process there exists only a limited understanding of the role of local ordering on the energy landscape. We have used neutron total scattering to show that disordered fluorite (induced intrinsically by composition/stoichiometry or at far-from-equilibrium conditions produced by high-energy radiation) consists of a local orthorhombic structural unit that is repeated by a pseudo-translational symmetry, such that orthorhombic and isometric arrays coexist at different length scales. We also show that inversion in isometric spinel occurs by a similar process. This insight provides a new basis for understanding order-to-disorder transformations important for applications such as plutonium immobilization, fast ion conduction, and thermal barrier coatings.

  18. Void lattice formation in electron irradiated CaF{sub 2}: Statistical analysis of experimental data and cellular automata simulations

    Energy Technology Data Exchange (ETDEWEB)

    Zvejnieks, G., E-mail: guntars@latnet.lv; Merzlyakov, P.; Kuzovkov, V.N.; Kotomin, E.A.

    2016-02-01

    Calcium fluoride (CaF{sub 2}) is an important optical material widely used in both microlithography and deep UV windows. It is known that under certain conditions electron beam irradiation can create therein a superlattice consisting of vacancy clusters (called a void lattice). The goal of this paper is twofold. Firstly, to perform a quantitative analysis of experimental TEM images demonstrating void lattice formation, we developed two distinct image filters. As a result, we can easily calculate vacancy concentration, vacancy cluster distribution function as well as average distances between defect clusters. The results for two suggested filters are similar and demonstrate that experimental void cluster growth is accompanied by a slight increase of the void lattice constant. Secondly, we proposed a microscopic model that allows us to reproduce a macroscopic void ordering, in agreement with experimental data, and to resolve existing theoretical and experimental contradictions. Our computer simulations demonstrate that macroscopic void lattice self-organization can occur only in a narrow parameter range. Moreover, we studied the kinetics of a void lattice ordering, starting from an initial disordered stage, in a good agreement with the TEM experimental data.

  19. A Cosmic Watershed: the WVF Void Detection Technique

    CERN Document Server

    Platen, Erwin; Jones, Bernard J T

    2007-01-01

    On megaparsec scales the Universe is permeated by an intricate filigree of clusters, filaments, sheets and voids, the Cosmic Web. For the understanding of its dynamical and hierarchical history it is crucial to identify objectively its complex morphological components. One of the most characteristic aspects is that of the dominant underdense Voids, the product of a hierarchical process driven by the collapse of minor voids in addition to the merging of large ones. In this study we present an objective void finder technique which involves a minimum of assumptions about the scale, structure and shape of voids. Our void finding method, the Watershed Void Finder (WVF), is based upon the Watershed Transform, a well-known technique for the segmentation of images. Importantly, the technique has the potential to trace the existing manifestations of a void hierarchy. The basic watershed transform is augmented by a variety of correction procedures to remove spurious structure resulting from sampling noise. This study c...

  20. Brain activation to task-irrelevant disorder-related threat in social anxiety disorder: The impact of symptom severity

    Directory of Open Access Journals (Sweden)

    Carina Yvonne Heitmann

    2017-01-01

    Full Text Available Unintentional and uncontrollable processing of threat has been suggested to contribute to the pathology of social anxiety disorder (SAD. The present study investigated the neural correlates of processing task-irrelevant, highly ecologically valid, disorder-related stimuli as a function of symptom severity in SAD. Twenty-four SAD patients and 24 healthy controls (HC performed a feature-based comparison task during functional magnetic resonance imaging, while task-irrelevant, disorder-related or neutral scenes were presented simultaneously at a different spatial position. SAD patients showed greater activity than HC in response to disorder-related versus neutral scenes in brain regions associated with self-referential processing (e.g. insula, precuneus, dorsomedial prefrontal cortex and emotion regulation (e.g. dorsolateral prefrontal cortex (dlPFC, inferior frontal gyrus. Symptom severity was positively associated with amygdala activity, and negatively with activation in dorsal anterior cingulate cortex and dlPFC in SAD patients. Additional correlation analysis revealed that amygdala-prefrontal coupling was positively associated with symptom severity. A network of brain regions is thus involved in SAD patients' processing of task-irrelevant, complex, ecologically valid, disorder-related scenes. Furthermore, increasing symptom severity in SAD patients seems to reflect a growing imbalance between neural mechanisms related to stimulus-driven bottom-up and regulatory top-down processes resulting in dysfunctional regulation strategies.

  1. Brain activation to task-irrelevant disorder-related threat in social anxiety disorder: The impact of symptom severity.

    Science.gov (United States)

    Heitmann, Carina Yvonne; Feldker, Katharina; Neumeister, Paula; Brinkmann, Leonie; Schrammen, Elisabeth; Zwitserlood, Pienie; Straube, Thomas

    2017-01-01

    Unintentional and uncontrollable processing of threat has been suggested to contribute to the pathology of social anxiety disorder (SAD). The present study investigated the neural correlates of processing task-irrelevant, highly ecologically valid, disorder-related stimuli as a function of symptom severity in SAD. Twenty-four SAD patients and 24 healthy controls (HC) performed a feature-based comparison task during functional magnetic resonance imaging, while task-irrelevant, disorder-related or neutral scenes were presented simultaneously at a different spatial position. SAD patients showed greater activity than HC in response to disorder-related versus neutral scenes in brain regions associated with self-referential processing (e.g. insula, precuneus, dorsomedial prefrontal cortex) and emotion regulation (e.g. dorsolateral prefrontal cortex (dlPFC), inferior frontal gyrus). Symptom severity was positively associated with amygdala activity, and negatively with activation in dorsal anterior cingulate cortex and dlPFC in SAD patients. Additional correlation analysis revealed that amygdala-prefrontal coupling was positively associated with symptom severity. A network of brain regions is thus involved in SAD patients' processing of task-irrelevant, complex, ecologically valid, disorder-related scenes. Furthermore, increasing symptom severity in SAD patients seems to reflect a growing imbalance between neural mechanisms related to stimulus-driven bottom-up and regulatory top-down processes resulting in dysfunctional regulation strategies.

  2. Relating Chromophoric and Structural Disorder in Conjugated Polymers

    CERN Document Server

    Simine, Lena

    2016-01-01

    The optoelectronic properties of amorphous conjugated polymers are sensitive to conformational disorder and spectroscopy provides the means for structural characterization of the fragments of the chain which interact with light - "chromophores". A faithful interpretation of spectroscopic conformational signatures, however, presents a key challenge. We investigate the relationship between the ground state optical gaps, the properties of the excited states, and the structural features of chromophores of a single molecule poly(3-hexyl)-thiophene (P3HT), using quantum-classical atomistic simulations. Our results demonstrate that chromophoric disorder reflects an interplay between excited state de-localization and electron-hole polarization, and is controlled by torsional disorder that is specifically associated with the presence of side chains. Within this conceptual framework, we predict and explain a counter-intuitive spectral signature of P3HT: a red-shifted absorption, despite shortening of chromophores, with...

  3. Voids in the SDSS DR9: observations, simulations, and the impact of the survey mask

    CERN Document Server

    Sutter, P M; Wandelt, Benjamin D; Weinberg, David H; Warren, Michael S

    2013-01-01

    We present and study cosmic voids identified using the watershed void finder ZOBOZ in the Sloan Digital Sky Survey Data Release 9, compare these voids to ones identified in mock catalogs, and assess the impact of the survey mask on void statistics such as number functions, ellipticity distributions, and radial density profiles. The nearly 1,000 identified voids span three volume-limited samples from redshift z=0.43 to 0.7. For comparison we use 98 of the publicly available 2LPT-based mock galaxy catalogs of Manera et al. (2012), and also generate our own mock catalogs by applying a Halo Occupation Distribution model to an N-body simulation. We find that the mask reduces the number density of voids at all scales by a factor of three and slightly skews the relative size distributions. This engenders an increase in the mean ellipticity by roughly 30%. However, we find that radial density profiles are largely robust to the effects of the mask. We see excellent agreement between the data and both mock catalogs, an...

  4. Alcohol abuse and related disorders treatment of alcohol dependence

    Directory of Open Access Journals (Sweden)

    Yu. P. Sivolap

    2014-01-01

    Full Text Available Alcohol abuse and alcoholism are the leading causes of worse health and increased mortality rates. Excessive alcohol consumption is the third leading cause of the global burden of diseases and a leading factor for lower lifespan and higher mortality. Alcohol abuse decreases working capacity and efficiency and requires the increased cost of the treatment of alcohol-induced disorders, which entails serious economic losses. The unfavorable medical and social consequences of excessive alcohol use determine the importance of effective treatment for alcoholism. The goals of rational pharmacotherapy of alcohol dependence are to enhance GABA neurotransmission, to suppress glutamate neurotransmission, to act on serotonin neurotransmission, to correct water-electrolyte balance, and to compensate for thiamine deficiency. Alcoholism treatment consists of two steps: 1 the prevention and treatment of alcohol withdrawal syndrome and its complications (withdrawal convulsions and delirium alcoholicum; 2 antirecurrent (maintenance therapy. Benzodiazepines are the drugs of choice in alleviating alcohol withdrawal and preventing its convulsive attacks and delirium alcoholicum. Diazepam and chlordiazepoxide are most commonly used for this purpose; the safer drugs oxazepam and lorazepam are given to the elderly and patients with severe liver lesions. Anticonvulsants having normothymic properties, such as carbamazepine, valproic acid, topiramate, and lamotrigine, are a definite alternative to benzodiazepines. The traditional Russian clinical practice (clearance detoxification has not a scientific base or significant impact on alcohol withdrawal-related states in addicts. Relapse prevention and maintenance therapy for alcohol dependence are performed using disulfiram, acamprosate, and naltrexone; since 2013 the European Union member countries have been using, besides these agents, nalmefene that is being registered in Russia. Memantine and a number of other

  5. Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins.

    Science.gov (United States)

    Butterfield, D A; Kanski, J

    2001-07-15

    Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in several age-related neurodegenerative disorders or animal models thereof, including Alzheimer's disease, Huntington's disease, prion disorders, such as Creutzfeld-Jakob disease, and alpha-synuclein disorders, such as Parkinson's disease and frontotemporal dementia. Each of these neurodegenerative disorders is associated with aggregated proteins in brain. However, the relationship among protein oxidation, protein aggregation, and neurodegeneration remain unclear. The current rapid progress in elucidation of mechanisms of protein oxidation in neuronal loss should provide further insight into the importance of free radical oxidative stress in these neurodegenerative disorders.

  6. Narcissistic disorder and the failure of symbolisation: a Relational Affective Hypothesis.

    Science.gov (United States)

    Mizen, C S

    2014-09-01

    The psychoanalytic concept of narcissistic disorder is broader than that of Narcissistic Personality Disorder (DSM-5 [1]), underlying a range of Personality Disorders (PD) and their co-morbidities. Existing Mentalisation, Psychoanalytic and Cognitive models, fail to account fully for the emerging evidence of biological, developmental, relational and defensive contributions to narcissistic disorder, nor do they account for the common and variant features of co-morbidities namely Anorexia Nervosa, Somatisation, Substance Misuse and Autistic Spectrum Disorder. Alexithymia and concrete modes of relating are common findings in narcissistic disorder and these co-morbid conditions. Current models do not provide a comprehensive account, on the basis of neuro-scientific and developmental evidence, of how affective feelings come to be represented in words and the association between narcissistic disorders and failures of symbolisation. In this paper I propose an empirically based Relational Affective Hypothesis that narcissistic disorder and its comorbidities represent failures at specific points on a representational function pathway through which subcortical affect and visceral feeling in a relational context become the basis for abstraction and language. The elucidation of this pathway allows investigation of the contribution of biological, social and psychogenic factors in narcissistic disorders. It also brings a new understanding of the neurological underpinning of psychodynamic defences in narcissistic disorders. Research and novel treatment implications are briefly considered.

  7. POLAR DISK GALAXY FOUND IN WALL BETWEEN VOIDS

    NARCIS (Netherlands)

    Stanonik, K.; Platen, E.; Aragon-Calvo, M. A.; van Gorkom, J. H.; van de Weygaert, R.; van der Hulst, J. M.; Peebles, P. J. E.

    2009-01-01

    We have found an isolated polar disk galaxy in what appears to be a cosmological wall situated between two voids. This void galaxy is unique as its polar disk was discovered serendipitously in an Hi survey of SDSS void galaxies, with no optical counterpart to the Hi polar disk. Yet the Hi mass in th

  8. POLAR DISK GALAXY FOUND IN WALL BETWEEN VOIDS

    NARCIS (Netherlands)

    Stanonik, K.; Platen, E.; Aragon-Calvo, M. A.; van Gorkom, J. H.; van de Weygaert, R.; van der Hulst, J. M.; Peebles, P. J. E.

    2009-01-01

    We have found an isolated polar disk galaxy in what appears to be a cosmological wall situated between two voids. This void galaxy is unique as its polar disk was discovered serendipitously in an Hi survey of SDSS void galaxies, with no optical counterpart to the Hi polar disk. Yet the Hi mass in th

  9. Prevalence of interpersonal trauma exposure and trauma-related disorders in severe mental illness

    NARCIS (Netherlands)

    Mauritz, M.W.; Goossens, P.J.J.; Draijer, N.; Achterberg, T. van

    2013-01-01

    BACKGROUND: Interpersonal trauma exposure and trauma-related disorders in people with severe mental illness (SMI) are often not recognized in clinical practice. OBJECTIVE: To substantiate the prevalence of interpersonal trauma exposure and trauma-related disorders in people with SMI. METHODS: We con

  10. Prevalence of interpersonal trauma exposure and trauma-related disorders in severe mental illness

    NARCIS (Netherlands)

    Mauritz, M.W.; Goossens, P.J.J.; Draijer, N.; Achterberg, T. van

    2013-01-01

    BACKGROUND: Interpersonal trauma exposure and trauma-related disorders in people with severe mental illness (SMI) are often not recognized in clinical practice. OBJECTIVE: To substantiate the prevalence of interpersonal trauma exposure and trauma-related disorders in people with SMI. METHODS: We

  11. Sex differences in neural responses to disgusting visual stimuli: implications for disgust-related psychiatric disorders.

    NARCIS (Netherlands)

    Caseras, X.; Mataix-Cols, D.; An, S.K.; Lawrence, N.S.; Speckens, A.E.M.; Giampietro, V.; Brammer, M.J.; Phillips, M.L.

    2007-01-01

    BACKGROUND: A majority of patients with disgust-related psychiatric disorders such as animal phobias and contamination-related obsessive-compulsive disorder are women. The aim of this functional magnetic resonance imaging (fMRI) study was to examine possible sex differences in neural responses to di

  12. The Relation between Anxiety Disorder and Experiential Avoidance in Inpatient Adolescents

    Science.gov (United States)

    Venta, Amanda; Sharp, Carla; Hart, John

    2012-01-01

    The current study aimed to examine the relation between experiential avoidance and anxiety disorders, as well as the usefulness of the Avoidance and Fusion Questionnaire for Youth (AFQ-Y; Greco, Lambert, & Baer, 2008) in detecting anxiety disorder in a sample of adolescent inpatients. First, the relation between experiential avoidance and anxiety…

  13. Are child anxiety and somatization associated with pain in pain-related functional gastrointestinal disorders?

    Science.gov (United States)

    This study investigated individual and incremental contributions of somatization and trait anxiety to pain report in children with pain-related functional gastrointestinal disorders. Eighty children (7-10 years) with pain-related functional gastrointestinal disorders completed the State-Trait Anxiet...

  14. "Dark energy" in the Local Void

    CERN Document Server

    Villata, M

    2012-01-01

    The unexpected discovery of the accelerated cosmic expansion in 1998 has filled the Universe with the embarrassing presence of an unidentified "dark energy", or cosmological constant, devoid of any physical meaning. While this standard cosmology seems to work well at the global level, improved knowledge of the kinematics and other properties of our extragalactic neighborhood indicates the need for a better theory. We investigate whether the recently suggested repulsive-gravity scenario can account for some of the features that are unexplained by the standard model. Through simple dynamical considerations, we find that the Local Void could host an amount of antimatter ($\\sim5\\times10^{15}\\,M_\\odot$) roughly equivalent to the mass of a typical supercluster, thus restoring the matter-antimatter symmetry. The antigravity field produced by this "dark repulsor" can explain the anomalous motion of the Local Sheet away from the Local Void, as well as several other properties of nearby galaxies that seem to require vo...

  15. Narrative Therapy to Prevent Illness-Related Stress Disorder

    Science.gov (United States)

    Petersen, Suni; Bull, Carolyn; Propst, Olivia; Dettinger, Sara; Detwiler, Laura

    2005-01-01

    More than 94% of cancer patients described the experience as the most traumatic event they have ever faced and 13% have posttraumatic stress disorder (PTSD) in the aftermath. Empirical evidence demonstrates that certain behaviors lead to more positive health outcomes. Although many patients automatically engage in these behaviors, many others do…

  16. MOG-IgG in NMO and related disorders

    DEFF Research Database (Denmark)

    Pache, Florence; Zimmermann, Hanna; Mikolajczak, Janine

    2016-01-01

    BACKGROUND: Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with aquaporin-4 antibody (AQP4-IgG)-negative neuromyelitis optica spectrum disorders (NMOSD). The objective of this study was to describe optic neuritis (ON)-induced neuro-axonal damage in...

  17. Clinical, molecular, and pharmacological aspects of FMR1 related disorders.

    Science.gov (United States)

    Pugin, A; Faundes, V; Santa María, L; Curotto, B; Aliaga, S; Salas, I; Soto, P; Bravo, P; Peña, M I; Alliende, M A

    2017-05-01

    Fragile X syndrome, the most common inherited cause of intellectual disability, is associated with a broad spectrum of disorders across different generations of a single family. This study reviews the clinical manifestations of fragile X-associated disorders as well as the spectrum of mutations of the fragile X mental retardation 1 gene (FMR1) and the neurobiology of the fragile X mental retardation protein (FMRP), and also provides an overview of the potential therapeutic targets and genetic counselling. This disorder is caused by expansion of the CGG repeat (>200 repeats) in the 5 prime untranslated region of FMR1, resulting in a deficit or absence of FMRP. FMRP is an RNA-binding protein that regulates the translation of several genes that are important in synaptic plasticity and dendritic maturation. It is believed that CGG repeat expansions in the premutation range (55 to 200 repeats) elicit an increase in mRNA levels of FMR1, which may cause neuronal toxicity. These changes manifest clinically as developmental problems such as autism and learning disabilities as well as neurodegenerative diseases including fragile X-associated tremor/ataxia syndrome (FXTAS). Advances in identifying the molecular basis of fragile X syndrome may help us understand the causes of neuropsychiatric disorders, and they will probably contribute to development of new and specific treatments. Copyright © 2014 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  18. Sleep-related disorders in chronic obstructive pulmonary disease.

    LENUS (Irish Health Repository)

    Crinion, Sophie J

    2014-02-01

    Sleep may have several negative consequences in patients with chronic obstructive pulmonary disease (COPD). Sleep is typically fragmented with diminished slow wave and rapid-eye-movement sleep, which likely represents an important contributing factor to daytime symptoms such as fatigue and lethargy. Furthermore, normal physiological adaptations during sleep, which result in mild hypoventilation in normal subjects, are more pronounced in COPD, which can result in clinically important nocturnal oxygen desaturation. The co-existence of obstructive sleep apnea and COPD is also common, principally because of the high prevalence of each disorder, and there is little convincing evidence that one disorder predisposes to the other. Nonetheless, this co-existence, termed the overlap syndrome, typically results in more pronounced nocturnal oxygen desaturation and there is a high prevalence of pulmonary hypertension in such patients. Management of sleep disorders in patients with COPD should address both sleep quality and disordered gas exchange. Non-invasive pressure support is beneficial in selected cases, particularly during acute exacerbations associated with respiratory failure, and is particularly helpful in patients with the overlap syndrome. There is limited evidence of benefit from pressure support in the chronic setting in COPD patients without obstructive sleep apnea.

  19. The reappraisal of benzodiazepines in the treatment of anxiety and related disorders.

    Science.gov (United States)

    Starcevic, Vladan

    2014-11-01

    Benzodiazepines (BDZs) continue to be shrouded in controversy, mainly because of dependence associated with their long-term use and some of their side effects. Despite treatment recommendations favoring newer antidepressants, BDZs are still commonly prescribed for anxiety and related disorders. Recent studies have demonstrated that long-term use of BDZs for these conditions can be effective and safe and that BDZs can be combined with psychological therapy and antidepressants to produce optimal outcomes. Such findings, along with a failure to convincingly demonstrate the overall superiority of alternative pharmacotherapy for anxiety and related disorders, have given an impetus to a reconsideration of the role of BDZs. This article reviews BDZs and other pharmacotherapy options for anxiety and related disorders and suggests that treatment guidelines should acknowledge that BDZs can be used as first-line, long-term pharmacological treatment for panic disorder, generalized anxiety disorder and social anxiety disorder.

  20. Attachment and social cognition in borderline personality disorder: Specificity in relation to antisocial and avoidant personality disorders.

    Science.gov (United States)

    Beeney, Joseph E; Stepp, Stephanie D; Hallquist, Michael N; Scott, Lori N; Wright, Aidan G C; Ellison, William D; Nolf, Kimberly A; Pilkonis, Paul A

    2015-07-01

    Theory and research point to the role of attachment difficulties in borderline personality disorder (BPD). Attachment insecurity is believed to lead to chronic problems in social relationships, attributable, in part, to impairments in social cognition, which comprise maladaptive mental representations of self, others, and self in relation to others. However, few studies have attempted to identify social-cognitive mechanisms that link attachment insecurity to BPD and to assess whether such mechanisms are specific to the disorder. For the present study, empirically derived indices of mentalization, self-other boundaries, and identity diffusion were tested as mediators between attachment style and personality disorder symptoms. In a cross-sectional structural equation model, mentalization and self-other boundaries mediated the relationship between attachment anxiety and BPD. Mentalization partially mediated the relationship between attachment anxiety and antisocial personality disorder (PD) symptoms, and self-other boundaries mediated the relationship between attachment anxiety.

  1. Health-Related Physical Fitness in Dutch Children With Developmental Coordination Disorder

    NARCIS (Netherlands)

    van der Hoek, Frouwien D.; Stuive, Ilse; Reinders-Messelink, Heleen A.; Holty, Lian; de Blecourt, Alida C. E.; Maathuis, Carel G. B.; van Weert, Ellen

    2012-01-01

    Objective: To compare components of health-related physical fitness between Dutch children with clinically diagnosed developmental coordination disorder (DCD) and typically developing children (TDC), and to examine associations between motor performance problems and components of health-related

  2. Health-Related Physical Fitness in Dutch Children With Developmental Coordination Disorder

    NARCIS (Netherlands)

    van der Hoek, Frouwien D.; Stuive, Ilse; Reinders-Messelink, Heleen A.; Holty, Lian; de Blecourt, Alida C. E.; Maathuis, Carel G. B.; van Weert, Ellen

    2012-01-01

    Objective: To compare components of health-related physical fitness between Dutch children with clinically diagnosed developmental coordination disorder (DCD) and typically developing children (TDC), and to examine associations between motor performance problems and components of health-related fitn

  3. Salvinorin a and related compounds as therapeutic drugs for psychostimulant-related disorders.

    Science.gov (United States)

    dos Santos, R G; Crippa, J A S; Machado-de-Sousa, J P; Hallak, J E C

    2014-01-01

    Pharmacological treatments are available for alcohol, nicotine, and opioid dependence, and several drugs for cannabis-related disorders are currently under investigation. On the other hand, psychostimulant abuse and dependence lacks pharmacological treatment. Mesolimbic dopaminergic neurons mediate the motivation to use drugs and drug-induced euphoria, and psychostimulants (cocaine, amphetamine, and methamphetamine) produce their effects in these neurons, which may be modulated by the opioid system. Salvinorin A is a κ-opioid receptor agonist extracted from Salvia divinorum, a hallucinogenic plant used in magico-ritual contexts by Mazateca Indians in México. Salvinorin A and its analogues have demonstrated anti-addiction effects in animal models using psychostimulants by attenuating dopamine release, sensitization, and other neurochemical and behavioral alterations associated with acute and prolonged administration of these drugs. The objective of the present article is to present an overview of the preclinical evidence suggesting anti-addictive effects of salvinorin A and its analogues.

  4. [The relation of selected psychiatric disorders to occurrence of suicide attempts among teenage psychiatrically hospitalized patients].

    Science.gov (United States)

    Krajewska, Katarzyna; Gawlik-Kotelnicka, Oliwia; Gmitrowicz, Agnieszka

    2015-06-01

    Suicide is the third cause of death globally in the age group 10-19. Multiple risk factors (genetic, psychiatric, psychological, familial, social) increased number of suicide attempts. The aim of this study was to explore whether mental disorders are associated with the number of suicide attempts among psychiatric hospitalized adolescents. Retrospective, chart-based analysis of 119 patients, aged 13-18, treated in 2013-2014 in the Department of Adolescent Psychiatry in Łódź. Inclusion criteria was diagnosis of schizophrenia, schizotypal and delusional disorders, mood disorders, neurotic, stress-related and somatoform disorders, behavioral and emotional disorders according to ICD 10. Exclusion criteria were other psychiatric diagnosis, incomplete information about intention of self-harm behaviors. For statistical analysis used Statistica 9.1. Among psychiatricaly hospitalized patients, 51.2% of people attempted suicide. No relationship was found (p > 0.05) between psychiatric diagnosis and frequency of suicide attempts in adolescents, but the most common suicide attempts related to people with a diagnosis of mood disorders (59.3%) and neurotic disorders (54.6%), and least frequently in patients with a diagnosis of schizophrenia , schizotypal and delusional disorders (40%) and behavioral and emotional disorders (44.4%). There is no relation between the occurrence of suicide attempts and the type of mental disorders among psychiatrically hospitalized adolescents. © 2015 MEDPRESS.

  5. Three-Dimensional Analysis of Voids in AM60B Magnesium Tensile Bars Using Computed Tomography Imagery

    Energy Technology Data Exchange (ETDEWEB)

    Waters, A M

    2001-05-01

    In an effort to increase automobile fuel efficiency as well as decrease the output of harmful greenhouse gases, the automotive industry has recently shown increased interest in cast light metals such as magnesium alloys in an effort to increase weight savings. Currently several magnesium alloys such as AZ91 and AM60B are being used in structural applications for automobiles. However, these magnesium alloys are not as well characterized as other commonly used structural metals such as aluminum. This dissertation presents a methodology to nondestructively quantify damage accumulation due to void behavior in three dimensions in die-cast magnesium AM60B tensile bars as a function of mechanical load. Computed tomography data was acquired after tensile bars were loaded up to and including failure, and analyzed to characterize void behavior as it relates to damage accumulation. Signal and image processing techniques were used along with a cluster labeling routine to nondestructively quantify damage parameters in three dimensions. Void analyses were performed including void volume distribution characterization, nearest neighbor distance calculations, shape parameters, and volumetric renderings of voids in the alloy. The processed CT data was used to generate input files for use in finite element simulations, both two- and three-dimensional. The void analyses revealed that the overwhelming source of failure in each tensile bar was a ring of porosity within each bar, possibly due to a solidification front inherent to the casting process. The measured damage parameters related to void nucleation, growth, and coalescence were shown to contribute significantly to total damage accumulation. Void volume distributions were characterized using a Weibull function, and the spatial distributions of voids were shown to be clustered. Two-dimensional finite element analyses of the tensile bars were used to fine-tune material damage models and a three-dimensional mesh of an extracted

  6. Are headache and temporomandibular disorders related? A blinded study

    DEFF Research Database (Denmark)

    Ballegaard, V.; Thede-Schmidt-Hansen, P.; Svensson, P.;

    2008-01-01

    To investigate overlaps between headache and temporomandibular disorders (TMD) in a clinical headache population and to describe the prevalence of TMD in headache patients, 99 patients referred to a specialized headache centre were diagnosed according to Research Diagnostic Criteria for TMD (RDC/TMD......) and classified in headache groups according to the International Classification of Headache Disorders, second edition for headache diagnoses in a blinded design. The prevalence of TMD in the headache population was 56.1%. Psychosocial dysfunction caused by TMD pain was observed in 40.4%. No significant...... differences in TMD prevalence were revealed between headache groups, although TMD prevalence tended to be higher in patients with combined migraine and tension-type headache. Moderate to severe depression was experienced by 54.5% of patients. Patients with coexistent TMD had a significantly higher prevalence...

  7. The Mechanism of Hydrogen-facilitating Initiation of Voids

    Institute of Scientific and Technical Information of China (English)

    褚武扬; 蒋兴钢; 肖纪美

    1994-01-01

    By combining the hydrogen-induced local plastic deformation theory with the decohesive theory and the hydrogen pressure theory, a new mechanism of hydrogen-facilitating initiation of voids has been proposed. Through facilitating the local plastic deformation and reducing the cohesive strength, hydrogen promotes both initiating a nanocrack and blunting the nanocrack into a void, resulting in hydrogen-promoting initiation of the void. On the other hand, hydrogen can enhance the stability of the void through reducing the cohesive strength and forming a hydrogen pressure in the void.

  8. Tracheostomy, lingular tonsillectomy and sleep-related breathing disorders.

    Science.gov (United States)

    Conache, I D; Meikle, D; O'Brien, C

    2002-05-01

    Laser resection of lingual tonsils and formal closure of a tracheostomy improved the airway in a 14-yr-old patient with Down's syndrome. Non-invasive airway support to treat obstructive sleep apnoea was postponed with this treatment. During the anaesthetic a laryngeal mask airway was used to support the airway after lingual tonsillectomy, to assess the suitability of defunctioning the tracheostomy. Laryngeal mask airways assist management of lingual tonsils. Lingual tonsillar hypertrophy can lead to obstructive sleep disorders.

  9. The Void Galaxy Survey: Photometry, structure and identity of void galaxies

    CERN Document Server

    Beygu, B; van der Hulst, J M; Jarrett, T H; Kreckel, K; van de Weygaert, R; van Gorkom, J H; Aragon-Calvo, M A

    2016-01-01

    We analyze photometry from deep B-band images of 59 void galaxies in the Void Galaxy Survey (VGS), together with their near-infrared 3.6$\\mu$m and 4.5$\\mu$m Spitzer photometry. The VGS galaxies constitute a sample of void galaxies that were selected by a geometric-topological procedure from the SDSS DR7 data release, and which populate the deep interior of voids. Our void galaxies span a range of absolute B-magnitude from $\\rm{M_B=-15.5}$ to $\\rm{M_B=-20}$, while at the 3.6$\\mu$m band their magnitudes range from $\\rm{M_{3.6}=-18}$ to $\\rm{M_{3.6}=-24}$. Their B-[3.6] colour and structural parameters indicate these are star forming galaxies. A good reflection of the old stellar population, the near-infrared band photometry also provide a robust estimate of the stellar mass, which for the VGS galaxies we confirm to be smaller than $3 \\times 10^{10}$ M$_\\odot$. In terms of the structural parameters and morphology, our findings align with other studies in that our VGS galaxy sample consists mostly of small late-t...

  10. A Cosmic Void Catalog of SDSS DR12 BOSS Galaxies

    Science.gov (United States)

    Mao, Qingqing; Berlind, Andreas A.; Scherrer, Robert J.; Neyrinck, Mark C.; Scoccimarro, Román; Tinker, Jeremy L.; McBride, Cameron K.; Schneider, Donald P.; Pan, Kaike; Bizyaev, Dmitry; Malanushenko, Elena; Malanushenko, Viktor

    2017-02-01

    We present a cosmic void catalog using the large-scale structure galaxy catalog from the Baryon Oscillation Spectroscopic Survey (BOSS). This galaxy catalog is part of the Sloan Digital Sky Survey (SDSS) Data Release 12 and is the final catalog of SDSS-III. We take into account the survey boundaries, masks, and angular and radial selection functions, and apply the ZOBOV void finding algorithm to the Galaxy catalog. We identify a total of 10,643 voids. After making quality cuts to ensure that the voids represent real underdense regions, we obtain 1,228 voids with effective radii spanning the range 20–100 {h}-1 {Mpc} and with central densities that are, on average, 30% of the mean sample density. We release versions of the catalogs both with and without quality cuts. We discuss the basic statistics of voids, such as their size and redshift distributions, and measure the radial density profile of the voids via a stacking technique. In addition, we construct mock void catalogs from 1000 mock galaxy catalogs, and find that the properties of BOSS voids are in good agreement with those in the mock catalogs. We compare the stellar mass distribution of galaxies living inside and outside of the voids, and find no large difference. These BOSS and mock void catalogs are useful for a number of cosmological and galaxy environment studies.

  11. Examining affect and perfectionism in relation to eating disorder symptoms among women with anorexia nervosa.

    Science.gov (United States)

    Lavender, Jason M; Mason, Tyler B; Utzinger, Linsey M; Wonderlich, Stephen A; Crosby, Ross D; Engel, Scott G; Mitchell, James E; Le Grange, Daniel; Crow, Scott J; Peterson, Carol B

    2016-07-30

    This study examined personality and affective variables in relation to eating disorder symptoms in anorexia nervosa (AN). Women (N=118) with DSM-IV AN completed baseline questionnaires (Beck Depression Inventory, Frost Multidimensional Perfectionism Scale) and interviews (Eating Disorder Examination, Yale-Brown-Cornell Eating Disorder Scale), followed by two weeks of ecological momentary assessment (EMA) involving multiple daily reports of affective states and eating disorder behaviors. Hierarchical regression analyses were conducted using eating disorder symptoms as dependent variables (i.e., EMA binge eating, EMA self-induced vomiting, eating disorder rituals, eating disorder preoccupations, dietary restraint). Predictor variables were maladaptive perfectionism (baseline), depressive symptoms (baseline), and affect lability (EMA). Results revealed that affect lability was independently associated with binge eating, whereas depressive symptoms were independently associated with self-induced vomiting. Depressive symptoms were independently associated with eating disorder rituals, whereas both depressive symptoms and maladaptive perfectionism were independently associated with eating disorder preoccupations. Finally, maladaptive perfectionism and affect lability were both independently associated with dietary restraint. This pattern of findings suggests the importance of affective and personality constructs in relation to eating disorder symptoms in AN and may highlight the importance of targeting these variables in the context of treatment.

  12. [Trauma and stressor-related disorders: diagnostic conceptualization in DSM-5].

    Science.gov (United States)

    Kapfhammer, H P

    2014-05-01

    The Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) includes a distinct diagnostic group of trauma and stressor-related disorders that has been set apart from anxiety disorders. From a perspective of adult psychiatry this new disorder category includes posttraumatic stress disorder (PTSD), acute stress disorder (ASD), and adjustment disorders. The PTSD is based on narrower trauma criteria that focus on acute life-threatening situations, serious injury, or sexual violence by way of direct confrontation, witnessing or indirect confrontation. Indirect confrontation, however, is reserved only for violent or accidental events that occurred to close family members or friends. The former A2 criterion of an intense emotional reaction to trauma has been removed. A deliberately broad approach to clinical PTSD phenomenology has created an empirically driven new cluster of persistent negative alterations in cognition and mood due to experiencing traumatic events. The ASD has been reconceptualized as an intense stress syndrome with a clear need of acute treatment during the early course after traumatic exposure. Adjustment disorders continue to emphasize maladaptive emotional and behavioral responses to unspecific, non-traumatic stressors in an intensity that is beyond social or cultural norms. Neither complex PTSD nor prolonged grief disorders have received an independent diagnostic status within DSM-5. With respect to stress-related disorders major divergences between DSM-5 and the future International Classification of Diseases 11 (ICD-11) are to be expected.

  13. An evaluation on occlusal relation and malocclusion in the incidence of temporomandibular disorders among Mashhad adolescents

    OpenAIRE

    Madani AS.; Ajami B

    2004-01-01

    Statement of Problem: In recent years, the prevalence of temporomandibular disorders among children and adolescents has increased, however, no study on the correlation between occlusal relations and temporomandibular disorders, in Mashhad adolescents, has been conducted yet. Purpose: The aim of this study was to survey the relationship between occlusal indices and temporomandibular disorders (TMD) among Mashhad adolescents, with the age range of 11-14 years old. Methods and Material: In this ...

  14. Psychiatric aspects of deafness and language disorder : related to motor disorder?

    NARCIS (Netherlands)

    Flapper, B.C.; Schoemaker, M.

    Children with “pure” receptive hearing impairment (RHI) and with specific language impairment (SLI) are not supposed to have additional developmental disabilities. However, mental health problems (MHP) may be associated with communicative disorders, and should be detected. Also motor coordination

  15. Personality, emotion-related variables, and media pressure predict eating disorders via disordered eating in Lebanese university students.

    Science.gov (United States)

    Sanchez-Ruiz, Maria Jose; El-Jor, Claire; Abi Kharma, Joelle; Bassil, Maya; Zeeni, Nadine

    2017-04-18

    Disordered eating behaviors are on the rise among youth. The present study investigates psychosocial and weight-related variables as predictors of eating disorders (ED) through disordered eating (DE) dimensions (namely restrained, external, and emotional eating) in Lebanese university students. The sample consisted of 244 undergraduates (143 female) aged from 18 to 31 years (M = 20.06; SD = 1.67). Using path analysis, two statistical models were built separately with restrained and emotional eating as dependent variables, and all possible direct and indirect pathways were tested for mediating effects. The variables tested for were media influence, perfectionism, trait emotional intelligence, and the Big Five dimensions. In the first model, media pressure, self-control, and extraversion predicted eating disorders via emotional eating. In the second model, media pressure and perfectionism predicted eating disorders via restrained eating. Findings from this study provide an understanding of the dynamics between DE, ED, and key personality, emotion-related, and social factors in youth. Lastly, implications and recommendations for future studies are advanced.

  16. Urodynamic analysis and treatment of male Parkinson's disease patients with voiding dysfunction

    Institute of Scientific and Technical Information of China (English)

    Xue Peng; Wang Tao; Zong Huantao; Zhang Yong

    2014-01-01

    Background Parkinson's disease (PD) is an extrapyramidal neurological disorder.Urinary symptoms are frequently present in patients affected by PD.Symptoms such as urgency,frequency,nocturia,and urge incontinence significantly impact the patient's quality of life.We attempted to investigate the urodynamic changes and treatment of male PD patients with voiding dysfunction by means of a review.Methods Comprehensive urodynamic examinations were performed in 141 male patients with PD associated with voiding dysfunction.Appropriate treatments were given to subgroups that were divided based on test results,and the changes in urodynamic parameters as well as the treatment efficacy were observed.Results Detrusor hyperreflexia without bladder outlet obstruction (BOO) was observed in 35 patients,who exhibited significant improvements in the international prostate symptom score (IPSS),maximum flow rate (Qmax),bladder volume at the first desire to void,post-void residual (PVR),and bladder compliance.Detrusor hyperreflexia associated with BOO was observed in 59 patients.The patients exhibited significant improvements in IPSS,Qmax,PVR,and bladder compliance.Detrusor dysfunction without BOO was observed in 19 patients,for whom the IPSS and the bladder volume at the first desire to void were improved after treatment.Detrusor dysfunction with BOO was found in 28 patients,with no significant improvement in the urodynamic parameters after the treatment.Conclusions Urodynamic examination is recommended for male Parkinson's disease patients with voiding dysfunction.Early and effective treatment can improve the bladder function and quality of life of these patients.

  17. Void-induced dissolution in molecular dynamics simulations of NaCl and water.

    Science.gov (United States)

    Bahadur, Ranjit; Russell, Lynn M; Alavi, Saman; Martin, Scot T; Buseck, Peter R

    2006-04-21

    To gain a better understanding of the interaction of water and NaCl at the surface during dissolution, we have used molecular dynamics to simulate the interface with two equal-sized slabs of solid NaCl and liquid water in contact. The introduction of voids in the bulk of the salt, as well as steps or pits on the surface of the NaCl slab results in a qualitative change of system structure, as defined by radial distribution functions (RDFs). As an example, the characteristic Na-Na RDF for the system changes from regularly spaced narrow peaks (corresponding to an ordered crystalline structure), to a broad primary and smaller secondary peak (corresponding to a disordered structure). The change is observed at computationally short time scales of 100 ps, in contrast with a much longer time scale of 1 mus expected for complete mixing in the absence of defects. The void fraction (which combines both bulk and surface defects) required to trigger dissolution varies between 15%-20% at 300 K and 1 atm, and has distinct characteristics for the physical breakdown of the crystal lattice. The void fraction required decreases with temperature. Sensitivity studies show a strong dependence of the critical void fraction on the quantity and distribution of voids on the surface, with systems containing a balanced number of surface defects and a rough surface showing a maximum tendency to dissolve. There is a moderate dependence on temperature, with a 5% decrease in required void fraction with a 100 K increase in temperature, and a weak dependence on water potential model used, with the SPC, SPC/E, TIP4P, and RPOL models giving qualitatively identical results. The results were insensitive to the total quantity of water available for dissolution and the duration of the simulation.

  18. Void-induced dissolution in molecular dynamics simulations of NaCl and water

    Science.gov (United States)

    Bahadur, Ranjit; Russell, Lynn M.; Alavi, Saman; Martin, Scot T.; Buseck, Peter R.

    2006-04-01

    To gain a better understanding of the interaction of water and NaCl at the surface during dissolution, we have used molecular dynamics to simulate the interface with two equal-sized slabs of solid NaCl and liquid water in contact. The introduction of voids in the bulk of the salt, as well as steps or pits on the surface of the NaCl slab results in a qualitative change of system structure, as defined by radial distribution functions (RDFs). As an example, the characteristic Na-Na RDF for the system changes from regularly spaced narrow peaks (corresponding to an ordered crystalline structure), to a broad primary and smaller secondary peak (corresponding to a disordered structure). The change is observed at computationally short time scales of 100ps, in contrast with a much longer time scale of 1μs expected for complete mixing in the absence of defects. The void fraction (which combines both bulk and surface defects) required to trigger dissolution varies between 15%-20% at 300K and 1atm, and has distinct characteristics for the physical breakdown of the crystal lattice. The void fraction required decreases with temperature. Sensitivity studies show a strong dependence of the critical void fraction on the quantity and distribution of voids on the surface, with systems containing a balanced number of surface defects and a rough surface showing a maximum tendency to dissolve. There is a moderate dependence on temperature, with a 5% decrease in required void fraction with a 100K increase in temperature, and a weak dependance on water potential model used, with the SPC, SPC/E, TIP4P, and RPOL models giving qualitatively identical results. The results were insensitive to the total quantity of water available for dissolution and the duration of the simulation.

  19. The Classification of Hysteria and Related Disorders: Historical and Phenomenological Considerations

    Directory of Open Access Journals (Sweden)

    Carol S. North

    2015-11-01

    Full Text Available This article examines the history of the conceptualization of dissociative, conversion, and somatoform syndromes in relation to one another, chronicles efforts to classify these and other phenomenologically-related psychopathology in the American diagnostic system for mental disorders, and traces the subsequent divergence in opinions of dissenting sectors on classification of these disorders. This article then considers the extensive phenomenological overlap across these disorders in empirical research, and from this foundation presents a new model for the conceptualization of these disorders. The classification of disorders formerly known as hysteria and phenomenologically-related syndromes has long been contentious and unsettled. Examination of the long history of the conceptual difficulties, which remain inherent in existing classification schemes for these disorders, can help to address the continuing controversy. This review clarifies the need for a major conceptual revision of the current classification of these disorders. A new phenomenologically-based classification scheme for these disorders is proposed that is more compatible with the agnostic and atheoretical approach to diagnosis of mental disorders used by the current classification system.

  20. The Classification of Hysteria and Related Disorders: Historical and Phenomenological Considerations

    Science.gov (United States)

    North, Carol S.

    2015-01-01

    This article examines the history of the conceptualization of dissociative, conversion, and somatoform syndromes in relation to one another, chronicles efforts to classify these and other phenomenologically-related psychopathology in the American diagnostic system for mental disorders, and traces the subsequent divergence in opinions of dissenting sectors on classification of these disorders. This article then considers the extensive phenomenological overlap across these disorders in empirical research, and from this foundation presents a new model for the conceptualization of these disorders. The classification of disorders formerly known as hysteria and phenomenologically-related syndromes has long been contentious and unsettled. Examination of the long history of the conceptual difficulties, which remain inherent in existing classification schemes for these disorders, can help to address the continuing controversy. This review clarifies the need for a major conceptual revision of the current classification of these disorders. A new phenomenologically-based classification scheme for these disorders is proposed that is more compatible with the agnostic and atheoretical approach to diagnosis of mental disorders used by the current classification system. PMID:26561836

  1. Treatment of fibromyalgia, myofascial pain, and related disorders.

    Science.gov (United States)

    Borg-Stein, Joanne

    2006-05-01

    Chronic muscle pain is a common complaint among patients who seek care for musculoskeletal disorders. A spectrum of clinical presentations exists, ranging from focal or regional complaints that usually represent myofascial pain syndromes to more wide spread pain that may meet criteria for a diagnosis of fibromyalgia. This article addresses the epidemiology, pathophysiology, and clinical management of myofascial pain syndrome and fibromyalgia. These conditions are challenging to treat and require physiatrists to be aware of the wide range of pharmacologic, rehabilitative,and psychosocial interventions that can be helpful.

  2. [Alert symptoms and related disorders in gifted children].

    Science.gov (United States)

    Robert, G; Kermarrec, S; Guignard, J-H; Tordjman, S

    2010-09-01

    Numerous questions on widely called "gifted" children remain unanswered. Based on our clinical experience in the first national center for high ability children and adolescents with difficulties, this article examines, after defining some terms and concepts, clinical signs associated with high ability children and psychopathological disorders frequently described in this population. The assessment of cognitive, socioemotional and conative profiles should allow to go beyond the simples/singles IQ measures, in order to provide a global scholastic, familial and social care tailored to the needs of the child and his or her environment. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  3. The void galaxy survey: photometry, structure and identity of void galaxies

    Science.gov (United States)

    Beygu, B.; Peletier, R. F.; van der Hulst, J. M.; Jarrett, T. H.; Kreckel, K.; van de Weygaert, R.; van Gorkom, J. H.; Aragon-Calvo, M. A.

    2017-01-01

    We analyse photometry from deep B-band images of 59 void galaxies in the Void Galaxy Survey (VGS), together with their near-infrared 3.6 μm and 4.5 μm Spitzer photometry. The VGS galaxies constitute a sample of void galaxies that were selected by a geometric-topological procedure from the Sloan Digital Sky Survey Data Release 7 data release, and which populate the deep interior of voids. Our void galaxies span a range of absolute B-magnitude from MB = -15.5 to -20, while at the 3.6 μm band their magnitudes range from M3.6 = -18 to -24. Their B-[3.6] colour and structural parameters indicate these are star-forming galaxies. A good reflection of the old stellar population, the near-infrared band photometry also provide a robust estimate of the stellar mass, which for the VGS galaxies we confirm to be smaller than 3 × 1010 M⊙. In terms of the structural parameters and morphology, our findings align with other studies in that our VGS galaxy sample consists mostly of small late-type galaxies. Most of them are similar to Sd-Sm galaxies, although a few are irregularly shaped galaxies. The sample even includes two early-type galaxies, one of which is an AGN. Their Sérsic indices are nearly all smaller than n = 2 in both bands and they also have small half-light radii. In all, we conclude that the principal impact of the void environment on the galaxies populating them mostly concerns their low stellar mass and small size.

  4. The Void Galaxy Survey: Galaxy Evolution and Gas Accretion in Voids

    Science.gov (United States)

    Kreckel, Kathryn; van Gorkom, Jacqueline H.; Beygu, Burcu; van de Weygaert, Rien; van der Hulst, J. M.; Aragon-Calvo, Miguel A.; Peletier, Reynier F.

    2016-10-01

    Voids represent a unique environment for the study of galaxy evolution, as the lower density environment is expected to result in shorter merger histories and slower evolution of galaxies. This provides an ideal opportunity to test theories of galaxy formation and evolution. Imaging of the neutral hydrogen, central in both driving and regulating star formation, directly traces the gas reservoir and can reveal interactions and signs of cold gas accretion. For a new Void Galaxy Survey (VGS), we have carefully selected a sample of 59 galaxies that reside in the deepest underdensities of geometrically identified voids within the SDSS at distances of ~100 Mpc, and pursued deep UV, optical, Hα, IR, and HI imaging to study in detail the morphology and kinematics of both the stellar and gaseous components. This sample allows us to not only examine the global statistical properties of void galaxies, but also to explore the details of the dynamical properties. We present an overview of the VGS, and highlight key results on the HI content and individually interesting systems. In general, we find that the void galaxies are gas rich, low luminosity, blue disk galaxies, with optical and HI properties that are not unusual for their luminosity and morphology. We see evidence of both ongoing assembly, through the gas dynamics between interacting systems, and significant gas accretion, seen in extended gas disks and kinematic misalignments. The VGS establishes a local reference sample to be used in future HI surveys (CHILES, DINGO, LADUMA) that will directly observe the HI evolution of void galaxies over cosmic time.

  5. Potential role of anticonvulsants in the treatment of obsessive-compulsive and related disorders.

    Science.gov (United States)

    Wang, Hee Ryung; Woo, Young Sup; Bahk, Won-Myong

    2014-10-01

    We reviewed the extant literature to evaluate the current evidence regarding the efficacy and safety of anticonvulsants in the treatment of obsessive-compulsive and related disorders. Relevant literature was accessed using the Cochrane database, embase and PubMed on 29 October 2013. Prospective studies examining the efficacy of anticonvulsants in obsessive-compulsive and related disorders were included. Case reports, case series, and retrospective studies were excluded. A total of 10 studies were included in this review. The studies of obsessive-compulsive disorder, except for two negative studies, showed favorable efficacy results of anticonvulsants. In one study on body dysmorphic disorder, levetiracetam showed favorable efficacy. In two lamotrigine studies for pathologic skin-picking, the efficacy findings were inconsistent. In one trichotillomania study, topiramate had reduced hair-pulling symptoms. Despite limited evidence, our review suggests that anticonvulsants have a potential role in the treatment of obsessive-compulsive and related disorders.

  6. Sex-related and non-sex-related comorbidity subtypes of tic disorders: a latent class approach.

    Science.gov (United States)

    Rodgers, S; Müller, M; Kawohl, W; Knöpfli, D; Rössler, W; Castelao, E; Preisig, M; Ajdacic-Gross, V

    2014-05-01

    Recent evidence suggests that there may be more than one Gilles de la Tourette syndrome (GTS)/tic disorder phenotype. However, little is known about the common patterns of these GTS/tic disorder-related comorbidities. In addition, sex-specific phenomenological data of GTS/tic disorder-affected adults are rare. Therefore, this community-based study used latent class analyses (LCA) to investigate sex-related and non-sex-related subtypes of GTS/tic disorders and their most common comorbidities. The data were drawn from the PsyCoLaus study (n = 3691), a population-based survey conducted in Lausanne, Switzerland. LCA were performed on the data of 80 subjects manifesting motor/vocal tics during their childhood/adolescence. Comorbid attention-deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder, depressive, phobia and panic symptoms/syndromes comprised the selected indicators. The resultant classes were characterized by psychosocial correlates. In LCA, four latent classes provided the best fit to the data. We identified two male-related classes. The first class exhibited both ADHD and depression. The second class comprised males with only depression. Class three was a female-related class depicting obsessive thoughts/compulsive acts, phobias and panic attacks. This class manifested high psychosocial impairment. Class four had a balanced sex proportion and comorbid symptoms/syndromes such as phobias and panic attacks. The complementary occurrence of comorbid obsessive thoughts/compulsive acts and ADHD impulsivity was remarkable. To the best of our knowledge, this is the first study applying LCA to community data of GTS symptoms/tic disorder-affected persons. Our findings support the utility of differentiating GTS/tic disorder subphenotypes on the basis of comorbid syndromes. © 2013 The Author(s) European Journal of Neurology © 2013 EFNS.

  7. Fibrillin abnormalities and prognosis in Marfan syndrome and related disorders

    Energy Technology Data Exchange (ETDEWEB)

    Aoyama, T.; Furthmayr, H.; Francke, U.; Gasner, C. [Stanford Univ. Medical Center, CA (United States)

    1995-08-28

    Marfan syndrome (MFS), a multisystem autosomal-dominant disorder, is characterized by mutations of the fibrillin-1 (FBN1) gene and by abnormal patterns of synthesis, secretion, and matrix deposition of the fibrillin protein. To determine the sensitivity and specificity of fibrillin protein abnormalities in the diagnosis of MFS, we studied dermal fibroblasts from 57 patients with classical MFS, 15 with equivocal MFS, 8 with single-organ manifestations, and 16 with other connective tissue disorders including homocystinuria and Ehlers-Danlos syndrome. Abnormal fibrillin metabolism was identified in 70 samples that were classified into four different groups based on quantitation of fibrillin synthesis and matrix deposition. Significant correlations were found for phenotypic features including arachnodactyly, striae distensae, cardiovascular manifestations, and fibrillin groups II and IV, which included 70% of the MFS patients. In addition, these two groups were associated with shortened {open_quotes}event-free{close_quotes} survival and more severe cardiovascular complications than groups I and III. The latter included most of the equivocal MFS/single manifestation patients with fibrillin abnormalities. Our results indicate that fibrillin defects at the protein level per se are not specific for MFS, but that the drastically reduced fibrillin deposition, caused by a dominant-negative effect of abnormal fibrillin molecules in individuals defined as groups II and IV, is of prognostic and possibly diagnostic significance. 25 refs., 3 figs., 6 tabs.

  8. New insights into HCV-related rheumatologic disorders: A review

    Directory of Open Access Journals (Sweden)

    Patrice Cacoub

    2017-03-01

    Full Text Available Hepatitis C virus (HCV infected patients are known to be exposed to major liver complications i.e. cirrhosis and hepatocellular carcinoma. In addition, many extrahepatic manifestations including rheumatologic disorders have been reported in up to two-third of HCV infected patients. These manifestations include frank auto-immune and rheumatic diseases (such as arthralgia, myalgia, arthritis, sicca syndrome and vasculitis which may dominate the course of infection. Until recently, the standard of care of HCV has been the use of interferon-alpha based regimens, which not only had limited effectiveness in HCV cure but were poorly tolerated. In patients with rheumatic diseases interferon-based regimens may be problematic given their association with a wide variety of autoimmune toxicities. Recent therapeutic advances with new direct anti-HCV therapies (interferon-free which are more effective and better tolerated, make screening for this comorbidity in patients with rheumatic disorders more important than ever. This review aimed to outline main HCV extrahepatic with a special focus on rheumatologic manifestations.

  9. Collapse of elongated voids in porous energetic materials: Effects of void orientation and aspect ratio on initiation

    Science.gov (United States)

    Rai, Nirmal Kumar; Schmidt, Martin J.; Udaykumar, H. S.

    2017-04-01

    The sensitivity of porous energetic materials depends on mesostructural heterogeneities such as voids, defects, cracks, and grain boundaries. The mesostructure of pressed explosives contains voids of arbitrary shapes including elongated voids of various orientations and aspect ratios. Mesoscale simulations to date have analyzed the effect of void morphology on the sensitivity of energetic materials for idealized shapes such as cylindrical, conical, and elliptical. This work analyzes the sensitivity behavior of elongated voids in an HMX matrix subject to shock loading. Simulations show that sensitivity of elongated voids depends strongly on orientation as well as aspect ratio. Ranges of orientations and aspects ratios are identified that enhance or inhibit initiation. Insights obtained from single elongated void analyses are used to identify sensitive locations in an imaged mesostructure of a pressed explosive sample.

  10. FINDbase: A relational database recording frequencies of genetic defects leading to inherited disorders worldwide

    NARCIS (Netherlands)

    S. van Baal (Sjozef); P. Kaimakis (Polynikis); M. Phommarinh (Manyphong); D. Koumbi (Daphne); H. Cuppens (Harry); F. Riccardino (Francesca); M. Macek (Milan MI); C.R. Scriver (Charles); G.P. Patrinos (George)

    2007-01-01

    textabstractFrequency of INherited Disorders database (FINDbase) (http://www.findbase.org) is a relational database, derived from the ETHNOS software, recording frequencies of causative mutations leading to inherited disorders worldwide. Database records include the population and ethnic group, the

  11. A Relational Cultural Approach to Working with Clients with Eating Disorders

    Science.gov (United States)

    Trepal, Heather C.; Boie, Ioana; Kress, Victoria E.

    2012-01-01

    The authors examine eating disorders through the conceptual framework of relational cultural theory (RCT). Taking into account the importance of relationships and connection, it is suggested that RCT may be a useful lens for conceptualizing and working with people who are experiencing eating disorders. Ways that RCT can be applied to enhance…

  12. Threat Related Selective Attention Predicts Treatment Success in Childhood Anxiety Disorders

    Science.gov (United States)

    Legerstee, Jeroen S.; Tulen, Joke H. M.; Kallen, Victor L.; Dieleman, Gwen C.; Treffers, Philip D. A.; Verhulst, Frank C.; Utens, Elisabeth M. W. J.

    2009-01-01

    Threat-related selective attention was found to predict the success of the treatment of childhood anxiety disorders through administering a pictorial dot-probe task to 131 children with anxiety disorders prior to cognitive behavioral therapy. The diagnostic status of the subjects was evaluated with a semistructured clinical interview at both pre-…

  13. FINDbase: A relational database recording frequencies of genetic defects leading to inherited disorders worldwide

    NARCIS (Netherlands)

    S. van Baal (Sjozef); P. Kaimakis (Polynikis); M. Phommarinh (Manyphong); D. Koumbi (Daphne); H. Cuppens (Harry); F. Riccardino (Francesca); M. Macek (Milan MI); C.R. Scriver (Charles); G.P. Patrinos (George)

    2007-01-01

    textabstractFrequency of INherited Disorders database (FINDbase) (http://www.findbase.org) is a relational database, derived from the ETHNOS software, recording frequencies of causative mutations leading to inherited disorders worldwide. Database records include the population and ethnic group, the

  14. Commentary on the Inclusion of Persistent Complex Bereavement-Related Disorder in DSM-5

    Science.gov (United States)

    Boelen, Paul A.; Prigerson, Holly G.

    2012-01-01

    The DSM-5 Anxiety, Obsessive-Compulsive Spectrum, Posttraumatic, and Dissociative Disorders Work Group has proposed criteria for Persistent Complex Bereavement-Related Disorder (PCBRD) for inclusion in the appendix of DSM-5. The authors feel that it is important that dysfunctional grief will become a formal condition in DSM-5 because that would…

  15. Voice Disorders in Teachers and Their Associations with Work-Related Factors: A Systematic Review

    Science.gov (United States)

    Cutiva, Lady Catherine Cantor; Vogel, Ineke; Burdorf, Alex

    2013-01-01

    Purpose: To provide a quantitative assessment of the occurrence of voice disorders among teachers and to identify associated work-related and individual factors in the teaching profession. Method: A systematic review was conducted using three computerized databases on the occurrence of voice disorders among teachers and their associations with…

  16. A Relational Cultural Approach to Working with Clients with Eating Disorders

    Science.gov (United States)

    Trepal, Heather C.; Boie, Ioana; Kress, Victoria E.

    2012-01-01

    The authors examine eating disorders through the conceptual framework of relational cultural theory (RCT). Taking into account the importance of relationships and connection, it is suggested that RCT may be a useful lens for conceptualizing and working with people who are experiencing eating disorders. Ways that RCT can be applied to enhance…

  17. Birth-Related Posttraumatic Stress Disorder: Implications for Early Intervention Services

    Science.gov (United States)

    Pizur-Barnekow, Kris; Doering, Jennifer J.; Willett, Marjorie; Ruminski, Christine; Spring, Molly

    2014-01-01

    The positive impact of healthy relationships on child development is widely accepted. A healthy relationship between mother and child is at risk when a mother experiences symptoms of birth-related posttraumatic stress disorder (PTSD). Mothers of children with special needs are at high risk for this disorder and early intervention (EI)…

  18. An adult version of the Screen for Child Anxiety Related Emotional Disorders (SCARED-A)

    NARCIS (Netherlands)

    van Steensel, F.J.A.; Bögels, S.M.

    2014-01-01

    Many questionnaires exist for measuring anxiety; however, most are developed for children or adults only, or do not capture symptoms of all anxiety disorders. The Screen for Child Anxiety Related Emotional Disorders (SCARED) is a well-validated questionnaire for children, measuring symptoms of most

  19. Prevalence of interpersonal trauma exposure and trauma-related disorders in severe mental illness

    Directory of Open Access Journals (Sweden)

    Maria W. Mauritz

    2013-04-01

    Full Text Available Background: Interpersonal trauma exposure and trauma-related disorders in people with severe mental illness (SMI are often not recognized in clinical practice. Objective: To substantiate the prevalence of interpersonal trauma exposure and trauma-related disorders in people with SMI. Methods: We conducted a systematic review of four databases (1980–2010 and then described and analysed 33 studies in terms of primary diagnosis and instruments used to measure trauma exposure and trauma-related disorders. Results: Population-weighted mean prevalence rates in SMI were physical abuse 47% (range 25–72%, sexual abuse 37% (range 24–49%, and posttraumatic stress disorder (PTSD 30% (range 20–47%. Compared to men, women showed a higher prevalence of sexual abuse in schizophrenia spectrum disorder, bipolar disorder, and mixed diagnosis groups labelled as having SMI. Conclusions: Prevalence rates of interpersonal trauma and trauma-related disorders were significantly higher in SMI than in the general population. Emotional abuse and neglect, physical neglect, complex PTSD, and dissociative disorders have been scarcely examined in SMI.

  20. Prevalence of interpersonal trauma exposure and trauma-related disorders in severe mental illness

    Science.gov (United States)

    Mauritz, Maria W.; Goossens, Peter J. J.; Draijer, Nel; van Achterberg, Theo

    2013-01-01

    Background Interpersonal trauma exposure and trauma-related disorders in people with severe mental illness (SMI) are often not recognized in clinical practice. Objective To substantiate the prevalence of interpersonal trauma exposure and trauma-related disorders in people with SMI. Methods We conducted a systematic review of four databases (1980–2010) and then described and analysed 33 studies in terms of primary diagnosis and instruments used to measure trauma exposure and trauma-related disorders. Results Population-weighted mean prevalence rates in SMI were physical abuse 47% (range 25–72%), sexual abuse 37% (range 24–49%), and posttraumatic stress disorder (PTSD) 30% (range 20–47%). Compared to men, women showed a higher prevalence of sexual abuse in schizophrenia spectrum disorder, bipolar disorder, and mixed diagnosis groups labelled as having SMI. Conclusions Prevalence rates of interpersonal trauma and trauma-related disorders were significantly higher in SMI than in the general population. Emotional abuse and neglect, physical neglect, complex PTSD, and dissociative disorders have been scarcely examined in SMI. PMID:23577228

  1. Commentary on the Inclusion of Persistent Complex Bereavement-Related Disorder in DSM-5

    Science.gov (United States)

    Boelen, Paul A.; Prigerson, Holly G.

    2012-01-01

    The DSM-5 Anxiety, Obsessive-Compulsive Spectrum, Posttraumatic, and Dissociative Disorders Work Group has proposed criteria for Persistent Complex Bereavement-Related Disorder (PCBRD) for inclusion in the appendix of DSM-5. The authors feel that it is important that dysfunctional grief will become a formal condition in DSM-5 because that would…

  2. Exploring Parents' Self-Blame in Relation to Adolescents' Mental Disorders

    Science.gov (United States)

    Moses, Tally

    2010-01-01

    This study examined whether parents of adolescents diagnosed with mental disorders self-blame for their child's disorders; their reasons for self-blame; and the relationships between parental self-blame and lower psychological well-being, perceived stigmatization, social support, potential hereditary factors related to adolescents' mental…

  3. Learning Processes Associated with Panic-Related Symptoms in Families with and without Panic Disordered Mothers

    Science.gov (United States)

    de Albuquerque, Jiske E. G.; Munsch, Simone; Margraf, Jurgen; Schneider, Silvia

    2013-01-01

    The present study compared learning processes associated with panic-related symptoms in families with and without panic disordered mothers. Using a multi-informant approach, 86 mothers [of whom 58 had a primary diagnosis of panic disorder (PD)], their partners and teenage children (mean age, 16.67 years) reported about parents' behavior (modeling…

  4. Threat Related Selective Attention Predicts Treatment Success in Childhood Anxiety Disorders

    Science.gov (United States)

    Legerstee, Jeroen S.; Tulen, Joke H. M.; Kallen, Victor L.; Dieleman, Gwen C.; Treffers, Philip D. A.; Verhulst, Frank C.; Utens, Elisabeth M. W. J.

    2009-01-01

    Threat-related selective attention was found to predict the success of the treatment of childhood anxiety disorders through administering a pictorial dot-probe task to 131 children with anxiety disorders prior to cognitive behavioral therapy. The diagnostic status of the subjects was evaluated with a semistructured clinical interview at both pre-…

  5. Voice disorders in teachers and their associations with work-related factors : A systematic review

    NARCIS (Netherlands)

    Cutiva, Lady Catherine Cantor; Vogel, Ineke; Burdorf, Alex

    2013-01-01

    Purpose: To provide a quantitative assessment of the occurrence of voice disorders among teachers and to identify associated work-related and individual factors in the teaching profession. Method: A systematic review was conducted using three computerized databases on the occurrence of voice disorde

  6. Mechanisms of Anxiety Related Attentional Biases in Children with Autism Spectrum Disorder

    Science.gov (United States)

    May, Tamara; Cornish, Kim; Rinehart, Nicole J.

    2015-01-01

    Children with autism spectrum disorder (ASD) have high levels of anxiety. It is unclear whether they exhibit threat-related attentional biases commensurate with anxiety disorders as manifest in non-ASD populations, such as facilitated attention toward, and difficulties disengaging engaging from, threatening stimuli. Ninety children, 45 cognitively…

  7. Mechanisms of Anxiety Related Attentional Biases in Children with Autism Spectrum Disorder

    Science.gov (United States)

    May, Tamara; Cornish, Kim; Rinehart, Nicole J.

    2015-01-01

    Children with autism spectrum disorder (ASD) have high levels of anxiety. It is unclear whether they exhibit threat-related attentional biases commensurate with anxiety disorders as manifest in non-ASD populations, such as facilitated attention toward, and difficulties disengaging engaging from, threatening stimuli. Ninety children, 45 cognitively…

  8. The mechanism and kinetics of void formation and growth in particulate filled PE composites

    Directory of Open Access Journals (Sweden)

    2007-11-01

    Full Text Available Volume strain measurements were carried out on PE/CaCO3 composites prepared with three different matrix polymers, containing various amounts of filler. The analysis of the debonding process and the various stages of void formation proved that the model developed for the prediction of the initiation of debonding is valid also for the studied PE/CaCO3 composites. Debonding stress is determined by the strength of interfacial adhesion, particle size and the stiffness of the matrix. In thermoplastic matrices usually two competitive processes take place: debonding and the plastic deformation of the polymer. The relative magnitude of the two processes strongly influences the number and size of the voids formed. Because of this competition and due to the wide particle size distribution of commercial fillers, only a certain fraction of the particles initiate the formation of voids. The number of voids formed is inversely proportional to the stiffness of the matrix polymer. In stiff matrices almost the entire amount of filler separates from the matrix under the effect of external load, while less than 30% debond in a PE which has an initial modulus of 0.4 GPa. Further decrease of matrix stiffness may lead to the complete absence of debonding and the composite would deform exclusively by shear yielding. Voids initiated by debonding grow during the further deformation of the composite. The size of the voids also depends on the modulus of the matrix. The rate of volume increase considerably exceeds the value predicted for cross-linked rubbers. At the same deformation and filler content the number of voids is smaller and their size is larger in soft matrices than in polymers with larger inherent modulus.

  9. Etiopathogenetic Mechanisms of Pulmonary Hypertension in Sleep-Related Breathing Disorders

    Directory of Open Access Journals (Sweden)

    Ayodeji Adegunsoye

    2012-01-01

    Full Text Available Obstructive sleep apnea syndrome is a common disorder with significant health consequences and is on the rise in consonance with the obesity pandemic. In view of the association between sleep-disordered breathing and pulmonary hypertension as depicted by multiple studies, current clinical practice guidelines categorize obstructive sleep apnea as a risk factor for pulmonary hypertension and recommend an assessment for sleep disordered breathing in evaluating patients with pulmonary hypertension. The dysregulatory mechanisms associated with hypoxemic episodes observed in sleep related breathing disorders contribute to the onset of pulmonary hypertension and identification of these potentially treatable factors might help in the reduction of overall cardiovascular mortality.

  10. Internet gaming disorder, social network disorder and laterality: handedness relates to pathological use of social networks

    OpenAIRE

    Bouna-Pyrrou, Polyxeni; Mühle, Christiane; Kornhuber, Johannes; Lenz, Bernd

    2015-01-01

    The internet age bears new challenges that include health risks. It is agreed that excessive internet use may reach pathological levels. However, the concept of internet addiction lacks specificity and, therefore, warrants studies on its diagnostic and etiologic classification. This study was conducted to characterize the novel DSM-5 criteria for internet gaming disorder and the adapted criteria for the “social network disorder”. Based on the established association of handedness and substanc...

  11. Plasticity size effects in voided crystals

    DEFF Research Database (Denmark)

    Hussein, M. I.; Borg, Ulrik; Niordson, Christian Frithiof

    singularities in an elastic material. The lattice resistance to dislocation motion, dislocation nucleation, dislocation interaction with obstacles and annihilation are incorporated through a set of constitutive rules. Over the range of length scales investigated, both the discrete dislocation and strain...... predictions of the two formulations for all crystal types and void volume fractions considered when the material length scale in the non-local plasticity model chosen to be $0.325\\mu m$ (around ten times the slip plane spacing in the discrete dislocation models)....

  12. Plasticity size effects in voided crystals

    DEFF Research Database (Denmark)

    Hussein, M.I.; Borg, Ulrik; Niordson, Christian Frithiof

    2008-01-01

    as line singularities in an elastic material. The lattice resistance to dislocation motion, dislocation nucleation, dislocation interaction with obstacles and annihilation are incorporated through a set of constitutive rules. Over the range of length scales investigated, both the discrete dislocation...... between predictions of the two formulations for all crystal types and void volume fractions considered when the material length scale in the non-local plasticity model is chosen to be 0.325 mu m (about 10 times the slip plane spacing in the discrete dislocation models)....

  13. Empirically derived dietary patterns in relation to psychological disorders.

    Science.gov (United States)

    Hosseinzadeh, Mahdieh; Vafa, Mohammadreza; Esmaillzadeh, Ahmad; Feizi, Awat; Majdzadeh, Reza; Afshar, Hamidreza; Keshteli, Ammar Hassanzadeh; Adibi, Peyman

    2016-02-01

    Psychological disorders are highly prevalent worldwide. The present study aimed to investigate the relationship between major dietary patterns and prevalence of psychological disorders in a large sample of Iranian adults. A cross-sectional study was done to identify dietary patterns derived from factor analysis. Dietary data were collected through the use of a validated dish-based semi-quantitative FFQ. Psychological health was examined by use of the Hospital Anxiety and Depression Scale and the General Health Questionnaire. The study was conducted in Isfahan, Iran, within the framework of the Study on Epidemiology of Psychological, Alimentary Health and Nutrition (SEPAHAN). Iranian adults (n 3846) aged 20-55 years. After adjustment for potential confounders, greater adherence to the lacto-vegetarian dietary pattern was protectively associated with depression in women (OR=0·65; 95 % CI 0·46, 0·91). Normal-weight participants in the top quintile of this dietary pattern tended to have decreased odds of anxiety compared with those in the bottom quintile (OR=0·61; 95 % CI 0·38, 1·00). In addition, the traditional dietary pattern was associated with increased odds of depression (OR=1·42; 95 % CI 1·01, 1·99) and anxiety (OR=1·56; 95 % CI 1·00, 2·42) in women. Normal-weight participants in the highest quintile of the traditional dietary pattern had greater odds for anxiety (OR=1·89; 95 % CI 1·12, 3·08) compared with those in the lowest quintile. The Western dietary pattern was associated with increased odds of depression in men (OR=1·73; 95 % CI 1·07, 2·81) and anxiety in normal-weight participants (OR=2·05; 95 % CI 1·22, 3·46). There was a significant increasing trend in the odds of psychological distress across increasing quintiles of the fast food dietary pattern in women (P-trend=0·02). Recommendation to increase the intake of fruits, citrus fruits, vegetables, tomato and low-fat dairy products and to reduce the intakes of snacks, high-fat dairy

  14. Perfectionism and Contingent Self-Worth in Relation to Disordered Eating and Anxiety.

    Science.gov (United States)

    Bardone-Cone, Anna M; Lin, Stacy L; Butler, Rachel M

    2017-05-01

    Perfectionism has been proposed as a transdiagnostic risk factor linked to eating disorders and anxiety. In the current study, we examine domains of contingent self-worth as potential moderators of the relationships between maladaptive perfectionism and disordered eating and anxiety using two waves of data collection. Undergraduate females (N = 237) completed online surveys of the study's core constructs at two points separated by about 14 months. At a bivariate level, maladaptive perfectionism was positively associated with disordered eating and anxiety. Maladaptive perfectionism and both appearance and relationship contingent self-worth interacted to predict increases in disordered eating. Neither of the interactive models predicted change in anxiety. Findings highlight maladaptive perfectionism as a transdiagnostic construct related to both disordered eating and anxiety. Interactive findings suggest that targeting maladaptive perfectionism and contingent self-worth (appearance, relationship) in prevention and treatment efforts could mitigate risk for the development or increase of disordered eating. Copyright © 2016. Published by Elsevier Ltd.

  15. Risk. Impact of having a first-degree relative with affective disorder

    DEFF Research Database (Denmark)

    Vinberg, Maj

    2016-01-01

    boundaries in order to have an impact on prevention. Furthermore, there is a need to move beyond the notion of ''magic bullets'', instead developing an integrated paradigm encompassing clusters of biomarkers related to behavioural measures of developmental psychopathology. Finally, as most psychiatric......: the high-risk group comprised twins at risk of developing affective disorder (DZ or MZ twin; index co-twin affected); the low risk group (control group) comprised twins at low risk of developing affective disorder (DZ or MZ twin; index co-twin not affected). At baseline 234 participants were divided......-risk twins and 5 low-risk twins) developed a psychiatric disorder during the 7-year follow-up period: 24 developed mood disorder (67%), 7 anxiety disorder (19%) and 5 (14%) substance abuse, schizophrenia or personality disorder. The results showed that familial risk, impaired stress tolerance and discrete...

  16. Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder

    DEFF Research Database (Denmark)

    Schaffer, Ayal; Isometsä, Erkki T; Tondo, Leonardo

    2015-01-01

    OBJECTIVES: Bipolar disorder is associated with elevated risk of suicide attempts and deaths. Key aims of the International Society for Bipolar Disorders Task Force on Suicide included examining the extant literature on epidemiology, neurobiology and pharmacotherapy related to suicide attempts...... and deaths in bipolar disorder. METHODS: Systematic review of studies from 1 January 1980 to 30 May 2014 examining suicide attempts or deaths in bipolar disorder, with a specific focus on the incidence and characterization of suicide attempts and deaths, genetic and non-genetic biological studies...... to women. People with bipolar disorder account for 3.4-14% of all suicide deaths, with self-poisoning and hanging being the most common methods. Epidemiological studies report that 23-26% of people with bipolar disorder attempt suicide, with higher rates in clinical samples. There are numerous genetic...

  17. Voids in Ly{\\alpha} Forest Tomographic Maps

    CERN Document Server

    Stark, Casey W; White, Martin; Lee, Khee-Gan

    2015-01-01

    We present a new method of finding cosmic voids using tomographic maps of Ly{\\alpha} forest flux. We identify cosmological voids with radii of 2 - 12 $h^{-1}$Mpc in a large N-body simulation at $z = 2.5$, and characterize the signal of the high-redshift voids in density and Ly{\\alpha} forest flux. The void properties are similar to what has been found at lower redshifts, but they are smaller and have steeper radial density profiles. Similarly to what has been found for low-redshift voids, the radial velocity profiles have little scatter and agree very well with the linear theory prediction. We run the same void finder on an ideal Ly{\\alpha} flux field and tomographic reconstructions at various spatial samplings. We compare the tomographic map void catalogs to the density void catalog and find good agreement even with modest-sized voids ($r > 6 \\, h^{-1}$Mpc). Using our simple void-finding method, the configuration of the ongoing CLAMATO survey covering 1 deg$^2$ would provide a sample of about 100 high-redshi...

  18. Parasomnias and other sleep-related movement disorders.

    Science.gov (United States)

    Lee-Chiong, Teofilo L

    2005-06-01

    Parasomnias are common clinical complaints. Formal sleep evaluation including PSG is indicated for parasomnias that are violent and potentially injurious; disruptive to the bed partner or other household members; accompanied by excessive daytime sleepiness; or associated with medical,psychiatric, or neurologic symptoms or findings [2]. Multiple sleep latency testing should be considered for patients who have complaints of excessive daytime sleepiness. An extensive history, including medical, neurologic,psychiatric, and sleep disorder, and a review of medication, alcohol, illicit drug use, and family history of parasomnias, may provide useful clues. Distinguishing between a parasomnia and a seizure may be difficult as both can present as recurrent, stereotypical behaviors. Evaluation may be aided by an expanded EEG montage during overnight PSG studies.

  19. [Developmental coordination disorder: relations between deficits in movement and cognition].

    Science.gov (United States)

    Kastner, Julia; Petermann, F

    2010-01-01

    Different studies confirm that children with developmental coordination disorders (DCD) feature additionally cognitive deficits in areas of visual perception, memory and processing speed. The aim of the present study was to explore, whether or not children suffering from DCD have specific performance profiles in the WISC-IV. For this purpose, the WISC-IV results of 40 children with DCD (diagnosed using the Movement ABC-2), mean age 7,60, were compared with a control group matched according to age und gender. The children in the clinical group offered a homogenous performance profile, scoring below average in each of the four indices (verbal comprehension, perception reasoning, working memory and processing speed) and general IQ. Therefore, in clinical practice the WISC-IV is an appropriate instrument to detect cognitive deficits that can appear in conjunction with DCD.

  20. Baryon effects on void statistics in the EAGLE simulation

    Science.gov (United States)

    Paillas, Enrique; Lagos, Claudia D. P.; Padilla, Nelson; Tissera, Patricia; Helly, John; Schaller, Matthieu

    2017-10-01

    Cosmic voids are promising tools for cosmological tests due to their sensitivity to dark energy, modified gravity and alternative cosmological scenarios. Most previous studies in the literature of void properties use cosmological N-body simulations of dark matter (DM) particles that ignore the potential effect of baryonic physics. Using a spherical underdensity finder, we analyse voids using the mass field and subhalo tracers in the Evolution and Assembly of Galaxies and their Environment (EAGLE) simulations, which follow the evolution of galaxies in a Λ cold dark matter universe with state-of-the-art subgrid models for baryonic processes in a (100 cMpc)3 volume. We study the effect of baryons on void statistics by comparing results with DM-only simulations that use the same initial conditions as EAGLE. When identifying voids in the mass field, we find that a DM-only simulation produces 24 per cent more voids than a hydrodynamical one due to the action of galaxy feedback polluting void regions with hot gas, specially for small voids with rvoid ≤ 10 Mpc. We find that the way in which galaxy tracers are selected has a strong impact on the inferred void properties. Voids identified using galaxies selected by their stellar mass are larger and have cuspier density profiles than those identified by galaxies selected by their total mass. Overall, baryons have minimal effects on void statistics, as void properties are well captured by DM-only simulations, but it is important to account for how galaxies populate DM haloes to estimate the observational effect of different cosmological models on the statistics of voids.

  1. Unique and related predictors of major depressive disorder, posttraumatic stress disorder, and their comorbidity after Hurricane Katrina.

    Science.gov (United States)

    Nillni, Yael I; Nosen, Elizabeth; Williams, Patrick A; Tracy, Melissa; Coffey, Scott F; Galea, Sandro

    2013-10-01

    The current study examined demographic and psychosocial factors that predict major depressive disorder (MDD) and comorbid MDD/posttraumatic stress disorder (MDD/PTSD) diagnostic status after Hurricane Katrina, one of the deadliest and costliest hurricanes in the history of the United States. This study expanded on the findings published in the article by Galea, Tracy, Norris, and Coffey (J Trauma Stress 21:357-368, 2008), which examined the same predictors for PTSD, to better understand related and unique predictors of MDD, PTSD, and MDD/PTSD comorbidity. A total of 810 individuals representative of adult residents living in the 23 southernmost counties of Mississippi before Hurricane Katrina were interviewed. Ongoing hurricane-related stressors, low social support, and hurricane-related financial loss were common predictors of MDD, PTSD, and MDD/PTSD, whereas educational and marital status emerged as unique predictors of MDD. Implications for postdisaster relief efforts that address the risk for both MDD and PTSD are discussed.

  2. Micturition disorders.

    Science.gov (United States)

    Byron, Julie K

    2015-07-01

    Evaluation of dogs and cats with micturition disorders can be challenging. It is important to determine the duration, timing, and frequency of the disorder, as well as assessing for any additional medical problems, such as neurologic or orthopedic disease, that may be affecting micturition. Observation of the patient during voiding can be particularly helpful in determining the type of disorder. Treatment of micturition disorders is varied and outcome depends on an accurate diagnosis. Patient response is also highly variable, even with appropriate therapy, and owners' expectations must be set accordingly.

  3. Properties of galaxy halos in Clusters and Voids

    CERN Document Server

    Antonuccio-Delogu, V; Pagliaro, A; Van Kampen, E; Colafrancesco, Sergio; Germaná, A; Gambera, M

    2000-01-01

    We use the results of a high resolution N-body simulation to investigate the role of the environment on the formation and evolution of galaxy-sized halos. Starting from a set of constrained initial conditions, we have produced a final configuration hosting a double cluster in one octant and a large void extending over two octants of the simulation box. In this paper we concentrate on {\\em gravitationally bound} galaxy-sized halos extracted from the two regions. Exploiting the high mass resolution of our simulation ($m_{body} = 2.1\\times 10^{9} h^{-1} M_{\\odot}$), we focus on halos with a relatively small mass: $5\\times 10^{10} \\leq M \\leq 2\\times 10^{12} M_{\\odot}$. We present results for two statistics: the relationship between 1-D velocity dispersion and mass and the probability distribution of the spin parameter $P(\\lambda)$. We do find a clear difference between halos lying in overdense regions and in voids. The \\svm relationship is well described by the Truncated Isothermal Sphere (TIS) model introduced ...

  4. Targeting the norepinephrinergic system in Parkinson's disease and related disorders : The locus coeruleus story

    NARCIS (Netherlands)

    Vermeiren, Yannick; De Deyn, Peter P.

    Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are related, progressive and debilitating neurodegenerative disorders with hallmark features that include a variety of motor and non-motor symptoms (behavioral, autonomic and cognitive dysfunction). For

  5. Are personality disturbances in anorexia nervosa related to emotion processing or eating disorder symptomatology?

    Science.gov (United States)

    Phillipou, Andrea; Gurvich, Caroline; Castle, David Jonathan; Rossell, Susan Lee

    2015-01-01

    Anorexia Nervosa (AN) is a psychiatric illness associated with a number of personality disturbances. However, whether these personality characteristics are related to eating disorder symptomatology or emotion regulation is unclear. The aim of this study was to investigate these relationships. Twenty-four individuals with AN and 25 age- and premorbid intelligence-matched controls completed the Personality Diagnostic Questionnaire, and scores were correlated with measures of emotionality and negative mood states, and eating disorder symptomatology. AN was associated with increased scores on schizoid, borderline, avoidant, dependent, obsessive compulsive, negativistic and depressive personality dimensions, relative to controls. In AN, eating disorder symptomatology did not significantly correlate with scores on any personality dimension. However, a number of personality characteristics were found to correlate with negative mood states. The findings suggest that personality disturbances in AN are not related to disorder-specific symptoms, but are related to negative mood states.

  6. The Void Galaxy Survey: Galaxy Evolution and Gas Accretion in Voids

    NARCIS (Netherlands)

    Kreckel, Kathryn; van Gorkom, Jacqueline H.; Beygu, Burcu; van de Weijgaert, Marinus; van der Hulst, J. M.; Aragon-Calvo, Miguel A.; Peletier, Reynier F.

    2014-01-01

    Voids represent a unique environment for the study of galaxy evolution, as the lower density environment is expected to result in shorter merger histories and slower evolution of galaxies. This provides an ideal opportunity to test theories of galaxy formation and evolution. Imaging of the neutral h

  7. The Void Galaxy Survey: Galaxy Evolution and Gas Accretion in Voids

    CERN Document Server

    Kreckel, Kathryn; Beygu, Burcu; van de Weygaert, Rien; van der Hulst, J M; Aragon-Calvo, Miguel A; Peletier, Reynier F

    2014-01-01

    Voids represent a unique environment for the study of galaxy evolution, as the lower density environment is expected to result in shorter merger histories and slower evolution of galaxies. This provides an ideal opportunity to test theories of galaxy formation and evolution. Imaging of the neutral hydrogen, central in both driving and regulating star formation, directly traces the gas reservoir and can reveal interactions and signs of cold gas accretion. For a new Void Galaxy Survey (VGS), we have carefully selected a sample of 59 galaxies that reside in the deepest underdensities of geometrically identified voids within the SDSS at distances of ~100 Mpc, and pursued deep UV, optical, Halpha, IR, and HI imaging to study in detail the morphology and kinematics of both the stellar and gaseous components. This sample allows us to not only examine the global statistical properties of void galaxies, but also to explore the details of the dynamical properties. We present an overview of the VGS, and highlight key re...

  8. The Void Galaxy Survey: Morphology and Star Formation Properties of Void Galaxies

    CERN Document Server

    Beygu, B; van der Hulst, J M; Peletier, R; Jarrett, T; van de Weygaert, R; van Gorkom, J H; Aragón-Calvo, M

    2015-01-01

    We present the structural and star formation properties of 59 void galaxies as part of the Void Galaxy Survey (VGS). Our aim is to study in detail the physical properties of these void galaxies and study the effect of the void environment on galaxy properties. We use Spitzer 3.6 $\\rm{\\mu m}$ and B-band imaging to study the morphology and color of the VGS galaxies. For their star formation properties, we use Halpha and GALEX near-UV imaging. We compare our results to a range of galaxies of different morphologies in higher density environments. We find that the VGS galaxies are in general disk dominated and star forming galaxies. Their star formation rates are, however, often less than 1 $\\rm{M_{\\odot}}$ $\\rm{yr^{-1}}$. There are two early-type galaxies in our sample as well. In $\\rm{r_{e}}$ versus $\\rm{M_{B}}$ parameter space, VGS galaxies occupy the same space as dwarf irregulars and spirals.

  9. The Void Galaxy Survey: Star Formation Properties

    CERN Document Server

    Beygu, B; van der Hulst, J M; Jarrett, T H; Peletier, R; van de Weygaert, R; van Gorkom, J H; Aragon-Calvo, M A

    2016-01-01

    We study the star formation properties of 59 void galaxies as part of the Void Galaxy Survey (VGS). Current star formation rates are derived from $\\rm{H\\alpha}$ and recent star formation rates from near-UV imaging. In addition, infrared 3.4 $\\rm{\\mu m}$, 4.6 $\\rm{\\mu m}$, 12 $\\rm{\\mu m}$ and 22 $\\rm{\\mu m}$ WISE emission is used as star formation and mass indicator. Infrared and optical colours show that the VGS sample displays a wide range of dust and metallicity properties. We combine these measurements with stellar and HI masses to measure the specific SFRs ($\\rm{SFR/M_{*}}$) and star formation efficiencies ($\\rm{SFR/M_{HI}}$). We compare the star formation properties of our sample with galaxies in the more moderate density regions of the cosmic web, 'the field'. We find that specific SFRs of the VGS galaxies as a function of stellar and HI mass are similar to those of the galaxies in these field regions. Their $\\rm{SFR\\alpha}$ is slightly elevated than the galaxies in the field for a given total HI mass. ...

  10. Cannabidiol regulation of learned fear: implications for treating anxiety-related disorders

    OpenAIRE

    Regimantas Jurkus; Harriet Laura Lavinia Day; Guimaraes, Francisco S.; Lee, Jonathan L. C.; Leandro Jose Bertoglio; Stevenson, Carl W.

    2016-01-01

    Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias and post-traumatic stress disorder (PTSD) are characterized by abnormal and persistent memories of fear-related contexts and cues. The effects of psychological treatments such as exposure therapy are often only temporary and medications can be ineffective and have adverse side effects. Growing evidence from human and animal studies indicates that cannabidiol, the main non-psychotomim...

  11. Relation of attachment style to behavioural disorders and abuse experienced by children and their parents

    OpenAIRE

    Pirsko, Laura

    2010-01-01

    Laura Pirsko Abstract Of doctoral thesis. Relation of attachment style to behavioural disorders and abuse experienced by children and their parents The goal of this thesis was to assess how attachment style of a child is related to development of behavioural disorders and their and their parents' experience of abuse. The result is a new scoring system for story stem narratives. Participants were children in early adolescence, their mothers and fathers from all regions ...

  12. Prevalence of metabolic syndrome-related disorders in a large adult population in Turkey

    OpenAIRE

    Yokusoglu Mehmet; Hasimi Adnan; Oktenli Cagatay; Sanisoglu S Yavuz; Ugurlu Mehmet

    2006-01-01

    Abstract Background There are few existing large population studies on the epidemiology of metabolic syndrome-related disorders of Turkey. The purpose of this study was to assess the prevalence of metabolic syndrome-related disorders in the Turkish adult population, to address sex, age, educational and geographical differences, and to examine blood pressure, body mass index, fasting blood glucose and serum lipids in Turkey. Methods This study was executed under the population study "The Healt...

  13. 'Void existence' as against 'annihilation existence': Differentiating two qualities in primitive mental states.

    Science.gov (United States)

    Valdarsky, Irit Hameiri

    2015-10-01

    This paper attempts to distil out a particular quality of psychic (non)existence, which I call here 'void existence', from the quality predominantly explored in the psychoanalytic discourse on primitive mental states, which I call 'annihilation existence'. Achieving this phenomenological differentiation may make it easier to identify and work through extreme states in the analytic situation, when the patient is under the dominance of 'void existence'. I suggest that it is, as it were, a one-dimensional existence, in an infinite contour-less void, lacking any substantial internal object, lacking any substantial sense of psychic and/or somatic occurrences, and lacking any live representation of this very state of being. Hence, it lacks distress and anxiety, as well as calmness and peace. One might say that it is the inorganic within the organic; a quality of non-alive-ness within life. 'Annihilation existence' is existence in a two- or three-dimensional hollowed world, with flat and/or partial representations of self and object, which attracts acute distress and annihilation anxiety. It is a sort of existence on the brink of non-life, on the brink of the void; where a sense of catastrophic danger is brought on by the never-ending potentiality of the annihilation's realization. Both these psychic qualities can be encapsulated within neurotic and personality disorders, and the dominance of each can serve as defence against the dominance of the other. The theoretical discussion is supported by excerpts from an analysis.

  14. Newtonian self-gravitating system in a relativistic huge void universe model

    Science.gov (United States)

    Nishikawa, Ryusuke; Nakao, Ken-ichi; Yoo, Chul-Moon

    2016-12-01

    We consider a test of the Copernican Principle through observations of the large-scale structures, and for this purpose we study the self-gravitating system in a relativistic huge void universe model which does not invoke the Copernican Principle. If we focus on the the weakly self-gravitating and slowly evolving system whose spatial extent is much smaller than the scale of the cosmological horizon in the homogeneous and isotropic background universe model, the cosmological Newtonian approximation is available. Also in the huge void universe model, the same kind of approximation as the cosmological Newtonian approximation is available for the analysis of the perturbations contained in a region whose spatial size is much smaller than the scale of the huge void: the effects of the huge void are taken into account in a perturbative manner by using the Fermi-normal coordinates. By using this approximation, we derive the equations of motion for the weakly self-gravitating perturbations whose elements have relative velocities much smaller than the speed of light, and show the derived equations can be significantly different from those in the homogeneous and isotropic universe model, due to the anisotropic volume expansion in the huge void. We linearize the derived equations of motion and solve them. The solutions show that the behaviors of linear density perturbations are very different from those in the homogeneous and isotropic universe model.

  15. The Optical Luminosity Function of Void Galaxies in the SDSS and ALFALFA Surveys

    CERN Document Server

    Moorman, Crystal M; Hoyle, Fiona; Pan, Danny C; Haynes, Martha P; Giovanelli, Riccardo

    2015-01-01

    We measure the r-band galaxy luminosity function (LF) across environments over the redshift range 0<$z$<0.107 using the SDSS. We divide our sample into galaxies residing in large scale voids (void galaxies) and those residing in denser regions (wall galaxies). The best fitting Schechter parameters for void galaxies are: log$\\Phi^*$= -3.40$\\pm$0.03 log(Mpc$^{-3}$), $M^*$= -19.88$\\pm$0.05, and $\\alpha$=-1.20$\\pm$0.02. For wall galaxies, the best fitting parameters are: log$\\Phi^*$=-2.86$\\pm$0.02 log(Mpc$^{-3}$), $M^*$=-20.80$\\pm$0.03, and $\\alpha$=-1.16$\\pm$0.01. We find a shift in the characteristic magnitude, $M^*$, towards fainter magnitudes for void galaxies and find no significant difference between the faint-end slopes of the void and wall galaxy LFs. We investigate how low surface brightness selections effects can affect the galaxy LF. To attempt to examine a sample of galaxies that is relatively free of surface brightness selection effects, we compute the optical galaxy LF of galaxies detected by ...

  16. Conductance of single microRNAs chains related to the autism spectrum disorder

    Science.gov (United States)

    Oliveira, J. I. N.; Albuquerque, E. L.; Fulco, U. L.; Mauriz, P. W.; Sarmento, R. G.; Caetano, E. W. S.; Freire, V. N.

    2014-09-01

    The charge transport properties of single-stranded microRNAs (miRNAs) chains associated to autism disorder were investigated. The computations were performed within a tight-binding model, together with a transfer matrix technique, with ionization energies and hopping parameters obtained by quantum chemistry method. Current-voltage (I× V) curves of twelve miRNA chains related to the autism spectrum disorders were calculated and analysed. We have obtained both semiconductor and insulator behavior, and a relationship between the current intensity and the autism-related miRNA bases sequencies, suggesting that a kind of electronic biosensor can be developed to distinguish different profiles of autism disorders.

  17. Quality of Smartphone Apps Related to Alcohol Use Disorder.

    Science.gov (United States)

    Penzenstadler, Louise; Chatton, Anne; Van Singer, Mathias; Khazaal, Yasser

    2016-01-01

    Apps for smartphones are opening an important range of opportunities for improving the care of people with alcohol use disorders (AUDs). This study aimed to evaluate the quality of English language apps for AUDs and to compare paid and free apps. The keywords 'alcohol', 'alcohol addiction', 'alcohol help' and 'stop drinking' were entered into the iTunes Store search engine. Apps were evaluated using a standardized assessment designed to rate the quality of apps in terms of accountability, interactivity, self-help score and evidence-based content. The Brief DISCERN score and the criteria of the 'Health on the Net' label were also used as content quality indicators. Of the 137 unique apps identified, 52 met the inclusion criteria. Overall, the content quality and self-help scores of these AUD apps were poor. The main quality indicators were not linked to payment status. Multiple linear regressions showed that the Brief DISCERN score significantly predicted content quality. Poor content quality and self-help scores of AUD smartphone apps underline the gap between their potential promises and the overall quality of available products in stores. The quality indicators used in the present study may be used for further app developments. © 2016 S. Karger AG, Basel.

  18. Ductile damage of porous materials with two populations of voids

    Science.gov (United States)

    Vincent, Pierre-Guy; Monerie, Yann; Suquet, Pierre

    2008-01-01

    This study is devoted to the modelling of ductile damage in uranium dioxide. This polycrystalline material contains two populations of voids of well separated size. The problem addressed here is the prediction of the effective flow surface of a Gurson material containing randomly oriented oblate voids. The case of spherical voids is considered first and the variational approach of Gurson is generalized by adding a compressible component to his original velocity field. The case of aligned oblate voids is then considered and a suitable generalization of a velocity field due to Gologanu et al. (ASME J. Engrg. Mater. Technol. 116 (1994) 290-297) is proposed. The extension to randomly oriented voids is achieved by averaging over all orientations. In each case, rigorous upper bounds and approximate estimates are derived and compared (in the case of spherical voids) with Finite Element simulations. To cite this article: P.-G. Vincent et al., C. R. Mecanique 336 (2008).

  19. Void alignment and density profile applied to measuring cosmological parameters

    CERN Document Server

    Dai, De-Chang

    2015-01-01

    We study the orientation and density profiles of the cosmological voids with SDSS10 data. Using voids to test Alcock-Paczynski effect has been proposed and tested in both simulations and actual SDSS data. Previous observations imply that there exist an empirical stretching factor which plays an important role in the voids' orientation. Simulations indicate that this empirical stretching factor is caused by the void galaxies' peculiar velocities. Recently Hamaus et al. found that voids' density profiles are universal and their average velocities satisfy linear theory very well. In this article we first confirm that the stretching effect exists using independent analysis. We then apply the universal density profile to measure the cosmological parameters. We find that the void density profile can be a tool to measure the cosmological parameters.

  20. Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders

    Directory of Open Access Journals (Sweden)

    Magdalena Grzesiak

    2017-01-01

    Full Text Available Aim. To assess the association of six polymorphisms in serotonin-related genes with depressive or anxiety disorders in patients with irritable bowel syndrome (IBS. Methods. The lifetime prevalence of depressive and anxiety disorders was assessed in 95 IBS patients (85% women using the Munich version of the Composite International Diagnostic Interview (CIDI. IBS was diagnosed according to the Rome III criteria. SCL6A4 HTTLPR polymorphism (rs4795541 was determined using PCR-based method. Single-nucleotide polymorphisms in HTR1A (rs6295, HTR2A (rs6313 and rs6311, HTR2C (rs6318, and TPH1 (rs1800532 were detected by minisequencing method. Results. IBS patients with depressive disorders were characterized by higher frequency of 5-HTTLPR L allele in comparison to IBS patients with anxiety disorders. The lower frequency of 1438 A allele in HTR2A was found in IBS patients with depressive disorders in comparison to IBS patients without mental disorders. The lower G allele frequency in HTR2C rs6318 polymorphism among IBS patients with anxiety disorders was also observed. Conclusions. Our results provide further evidence for the involvement of SLC6A4 rs4795541 and HTR2A rs6311 polymorphisms in the pathophysiology of depressive disorders in IBS patients. The new findings indicate that HTR2C rs6318 polymorphism may be associated with the susceptibility to anxiety disorders in IBS patients.

  1. Review on risk factors related to lower back disorders at workplace

    Science.gov (United States)

    A' Tifah Jaffar, Nur; Nasrull Abdol Rahman, Mohd

    2017-08-01

    This review examines the evidence of the occurrence of risk exposure on work-related lower back disorders in the workplace. This review also investigates potential interactions between the risk factors in the workplace which include heavy physical work risk factor, static work postures risk factor, frequent bending and twisting risk factor, lifting risk factor, pushing and pulling risk factor, repetitive work risk factor, vibration risk factor, psychological and psychosocial risk factor that may be associated with symptoms of musculoskeletal disorders of lower back. These risk factors can reinforce each other and their influence can also be mediated by cultural or social factors. A systematic review of the literature was carried out by searching using databases and the searching strategy was used combined keyword for risk factors, work-related lower back disorders, heavy physical work, static work postures, frequent bending and twisting, lifting, pushing and pulling, repetitive work, vibration, psychological and psychosocial risk factor. A total of 67 articles were identified and reviewed. The risk factors identified that related for low back disorder are seven which are heavy physical work, static work postures, frequent bending and twisting, lifting, pushing and pulling, repetitive work, vibration, psychological and psychosocial risk factor and the level of evidence supporting the relationship with lower back disorders also described such as strong, moderate, insufficient, limited and no evidence. This result confirms that, existing of higher physical and psychosocial demand related to reported risk factors of low back disorders. The result also showed that previous reviews had evaluated relationship between risk factors of low back disorders and specific types of musculoskeletal disorders. This review also highlights the scarves evidence regarding some of the frequently reported risk factors for work related lower back disorders.

  2. Mechanisms of comorbidity, continuity, and discontinuity in anxiety-related disorders.

    Science.gov (United States)

    McNaughton, Neil; Corr, Philip J

    2016-11-01

    We discuss comorbidity, continuity, and discontinuity of anxiety-related disorders from the perspective of a two-dimensional neuropsychology of fear (threat avoidance) and anxiety (threat approach). Pharmacological dissection of the "neurotic" disorders justifies both a categorical division between fear and anxiety and a subdivision of each mapped to a hierarchy of neural modules that process different immediacies of threat. It is critical that each module can generate normal responses, symptoms of another syndrome, or syndromal responses. We discuss the resultant possibilities for comorbid dysfunction of these modules both with each other and with some disorders not usually classified as anxiety related. The simplest case is symptomatic fear/anxiety comorbidity, where dysfunction in one module results in excess activity in a second, otherwise normal, module to generate symptoms and apparent comorbidity. More complex is syndromal fear/anxiety comorbidity, where more than one module is concurrently dysfunctional. Yet more complex are syndromal comorbidities of anxiety that go beyond the two dimensional fear/anxiety systems: depression, substance use disorder, and attention-deficit/hyperactivity disorder. Our account of attention-deficit/hyperactivity disorder-anxiety comorbidity entails discussion of the neuropsychology of externalizing disorders to account for the lack of anxiety comorbidity in some of these. Finally, we link the neuropsychology of disorder to personality variation, and to the development of a biomarker of variation in the anxiety system among individuals that, if extreme, may provide a means of unambiguously identifying the first of a range of anxiety syndromes.

  3. Adjustment disorders as a stress-related disorder: a longitudinal study of the associations among stress, resources, and mental health.

    Directory of Open Access Journals (Sweden)

    Rüya-Daniela Kocalevent

    Full Text Available OBJECTIVE: Adjustment disorders are re-conceptualized in the DSM-5 as a stress-related disorder; however, besides the impact of an identifiable stressor, the specification of a stress concept, remains unclear. This study is the first to examine an existing stress-model from the general population, in patients diagnosed with adjustment disorders, using a longitudinal design. METHODS: The study sample consisted of 108 patients consecutively admitted for adjustment disorders. Associations of stress perception, emotional distress, resources, and mental health were measured at three time points: the outpatients' presentation, admission for inpatient treatment, and discharge from the hospital. To evaluate a longitudinal stress model of ADs, we examined whether stress at admission predicted mental health at each of the three time points using multiple linear regressions and structural equation modeling. A series of repeated-measures one-way analyses of variance (rANOVAs was performed to assess change over time. RESULTS: Significant within-participant changes from baseline were observed between hospital admission and discharge with regard to mental health, stress perception, and emotional distress (p<0.001. Stress perception explained nearly half of the total variance (44% of mental health at baseline; the adjusted R2 increased (0.48, taking emotional distress (i.e., depressive symptoms into account. The best predictor of mental health at discharge was the level of emotional distress (i.e., anxiety level at baseline (β= -0.23, R2corr=0.56, p<0.001. With a CFI of 0.86 and an NFI of 0.86, the fit indices did not allow for acceptance of the stress-model (Cmin/df=15.26; RMSEA=0.21. CONCLUSIONS: Stress perception is an important predictor in adjustment disorders, and mental health-related treatment goals are dependent on and significantly impacted by stress perception and emotional distress.

  4. Discovering relations between mind, brain, and mental disorders using topic mapping.

    Directory of Open Access Journals (Sweden)

    Russell A Poldrack

    Full Text Available Neuroimaging research has largely focused on the identification of associations between brain activation and specific mental functions. Here we show that data mining techniques applied to a large database of neuroimaging results can be used to identify the conceptual structure of mental functions and their mapping to brain systems. This analysis confirms many current ideas regarding the neural organization of cognition, but also provides some new insights into the roles of particular brain systems in mental function. We further show that the same methods can be used to identify the relations between mental disorders. Finally, we show that these two approaches can be combined to empirically identify novel relations between mental disorders and mental functions via their common involvement of particular brain networks. This approach has the potential to discover novel endophenotypes for neuropsychiatric disorders and to better characterize the structure of these disorders and the relations between them.

  5. Work-related musculoskeletal disorder: An occupational disorder of the goldsmiths in India

    Directory of Open Access Journals (Sweden)

    Ghosh Tirthankar

    2010-01-01

    Full Text Available Background: Gold ornament making industries are one of the widespread small-scale industries of India. These industries belong to the unorganized sector of the state. A large number of goldsmiths are working there for prolonged period in cross leg posture at semi-confined workstation. Objectives: The aim of this study is to identify Occupational Disorder of the Goldsmiths in India. Materials and Methods: In the spresent study, 120 male goldsmiths were randomly selected from the Davangere district of Karnataka. A detailed questionnaire study on discomfort feeling was done by the modified Nordic questionnaire, which considering the information about work nature, job stress and discomfort feeling. The existing workstations were assessed by the measurement of work areas. Analysis of body posture by rapid upper limb assessment was done to evaluate the work stress during their job. Results: From the analysis, it was revealed that MSDs were the major problem of the goldsmiths. The activities of the goldsmiths were also highly repetitive. Moreover, the questionnaire study revealed that most of the workers were affected by occupational disorder like pain at neck (80%, shoulder (20%, wrist (45%, and low back (75% and also eye problem like irritation (30% and burning sensation (70%. They also perform their job in hazardous postures. It was recorded that the workstations were poorly illuminated (19 Lux in respect to precision work. Accidents like cut and burn occurred frequently due to the unsafe condition of the workstation. Conclusions: From the observation and analysis of the result it was concluded that health of the goldsmiths were highly affected improper body posture and workload. Twisting, bending, and over-reaching are the resultant of poorly designed workstation. These actions force them into a non-neutral position that increases the overall discomfort and pain at the lower back, neck, and shoulders. Moreover, lack of proper illumination at work

  6. Measurement of void fractions by nuclear techniques; Medicion de fracciones de vacio por tecnicas nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez G, A.; Vazquez G, J.; Diaz H, C.; Salinas R, G.A. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    In this work it is done a general analysis of those techniques used to determine void fractions and it is chosen a nuclear technique to be used in the heat transfer circuit of the Physics Department of the Basic Sciences Management. The used methods for the determination of void fractions are: radioactive absorption, acoustic techniques, average velocity measurement, electromagnetic flow measurement, optical methods, oscillating absorption, nuclear magnetic resonance, relation between pressure and flow oscillation, infrared absorption methods, sound neutron analysis. For the case of this work it will be treated about the radioactive absorption method which is based in the gamma rays absorption. (Author)

  7. An observational detection of the bridge effect of void filaments

    CERN Document Server

    Shim, Junsup; Hoyle, Fiona

    2015-01-01

    The bridge effect of void filaments is a phrase coined by Park & Lee (2009b) to explain the correlations found in a numerical experiment between the luminosity of the void galaxies and the degree of the straightness of their host filaments. Their numerical finding implies that a straight void filament provides a narrow channel for the efficient transportation of gas and matter particles from the surroundings into the void galaxies. To observationally confirm the presence of the bridge effect of void filaments, we identify the filamentary structures from the Sloan void catalog and determine the specific size of each void filament as a measure of its straightness. Using both classical and Bayesian statistics, we indeed detect a strong tendency that the void galaxies located in the more straight filaments are on average more luminous, which is in agreement with the numerical prediction. It is also shown that the strength of correlation increases with the spatial extent of the void filaments, which can be phy...

  8. Quantifying Effects of Voids in Woven Ceramic Matrix Composites

    Science.gov (United States)

    Goldsmith, Marlana B.; Sankar, Bhavani V.; Haftka, Raphael T.; Goldberg, Robert K.

    2013-01-01

    Randomness in woven ceramic matrix composite architecture has been found to cause large variability in stiffness and strength. The inherent voids are an aspect of the architecture that may cause a significant portion of the variability. A study is undertaken to investigate the effects of many voids of random sizes and distributions. Response surface approximations were formulated based on void parameters such as area and length fractions to provide an estimate of the effective stiffness. Obtaining quantitative relationships between the properties of the voids and their effects on stiffness of ceramic matrix composites are of ultimate interest, but the exploratory study presented here starts by first modeling the effects of voids on an isotropic material. Several cases with varying void parameters were modeled which resulted in a large amount of variability of the transverse stiffness and out-of-plane shear stiffness. An investigation into a physical explanation for the stiffness degradation led to the observation that the voids need to be treated as an entity that reduces load bearing capabilities in a space larger than what the void directly occupies through a corrected length fraction or area fraction. This provides explanation as to why void volume fraction is not the only important factor to consider when computing loss of stiffness.

  9. On de-Sitter Geometry in Cosmic Void Statistics

    CERN Document Server

    Gibbons, Gary W; Yoshida, Naoki; Chon, Sunmyon

    2013-01-01

    Starting from the geometrical concept of a 4-dimensional de-Sitter configuration of spheres in Euclidean 3-space and modelling voids in the Universe as spheres, we show that a uniform distribution over this configuration space implies a power-law for the void number density which is consistent with results from the excursion set formalism and from data, for an intermediate range of void volumes. We also discuss the effect of restricting the survey geometry on the void statistics. This work is a new application of de-Sitter geometry to cosmology and also provides a new geometrical perspective on self-similarity in cosmology.

  10. DSM-V diagnostic criteria for bereavement-related disorders in children and adolescents: developmental considerations.

    Science.gov (United States)

    Kaplow, Julie B; Layne, Christopher M; Pynoos, Robert S; Cohen, Judith A; Lieberman, Alicia

    2012-01-01

    Two bereavement-related disorders are proposed for the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V): Adjustment Disorder Related to Bereavement, to be located in the main body of the text as an official diagnostic entity; and Bereavement-Related Disorder, including a Traumatic Death Specifier, to be located in the Appendix as an invitation for further research. These diagnoses currently do not include developmentally informed criteria, despite the importance of developmental processes in the ways children and adolescents grieve. In this article, we draw upon a selective review of the empirical literature and expert clinical knowledge to recommend developmentally informed modifications and specifiers of the proposed criteria for both bereavement disorders and strategies to improve future research. This article is derived from an invited report submitted to the DSM-V Posttraumatic Stress Disorder, Trauma, and Dissociative Disorders Sub-Work Group, and suggested modifications have received preliminary approval to be incorporated into the DSM-V at the time of this writing. Adoption of these proposals will have far-reaching consequences, given that DSM-V criteria will influence both critical treatment choices for bereaved youth and the next generation of research studies.

  11. Terrorism, civil war and related violence and substance use disorder morbidity and mortality: a global analysis.

    Science.gov (United States)

    Kerridge, Bradley T; Khan, Maria R; Rehm, Jürgen; Sapkota, Amir

    2014-03-01

    The purpose of this study is to examine associations between deaths owing to terrorism, civil war, and one-sided violence from 1994-2000 and substance use disorder disability-adjusted life years (DALYs). The relationship between terrorism, and related violence and substance use disorder morbidity and mortality among World Health Organization Member States in 2002, controlling for adult per capita alcohol consumption, illicit drug use, and economic variables at baseline in 1994. Deaths as a result of terrorism and related violence were related to substance use disorder DALYs: a 1.0% increase in deaths as a result of terrorism, war and one-sided violence was associated with an increase of between 0.10% and 0.12% in alcohol and drug use disorder DALYs. Associations were greater among males and 15-44 year-old. Terrorism, war and one-sided violence may influence morbidity and mortality attributable to substance use disorders in the longer-term suggests that more attention to be given to rapid assessment and treatment of substance use disorders in conflict-affected populations with due consideration of gender and age differences that may impact treatment outcomes in these settings. Priorities should be established to rebuild substance abuse treatment infrastructures and treat the many physical and mental comorbid disorders. Copyright © 2014. Published by Elsevier Ltd.

  12. A longitudinal investigation of sports-related risk factors for disordered eating in aesthetic sports.

    Science.gov (United States)

    Krentz, E M; Warschburger, P

    2013-06-01

    Previous studies have indicated a higher risk of disordered eating in certain types of elite sports such as aesthetic sports (e.g., rhythmical gymnastics, figure skating). But even though some studies on risk factors for disordered eating in sports exist, most research on this topic is based on cross-sectional data with limitations on causal inferences. We examined sports-related risk factors for disordered eating in a 1-year longitudinal study with two assessment points. The participants were 65 adolescent athletes from aesthetic sports (mean age 14.0  ±.2.2 years) who completed measures of disordered eating, social pressure from the sports environment, sports-related body dissatisfaction, desire to be leaner to improve sports performance, and emotional distress resulting from missed exercise sessions. All variables were relatively stable in the mean. Individual changes in the desire to be leaner to improve sports performance were associated with individual changes in disordered eating. Furthermore, a cross-lagged partial correlation analysis showed that the desire to be leaner to improve sports performance was predictive of disordered eating and not vice versa. The results of our study indicate that athletes are more at risk for disordered eating if they believe it is possible to enhance their sports performance through weight regulation.

  13. Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity.

    Science.gov (United States)

    Elli, Luca; Branchi, Federica; Tomba, Carolina; Villalta, Danilo; Norsa, Lorenzo; Ferretti, Francesca; Roncoroni, Leda; Bardella, Maria Teresa

    2015-06-21

    Cereal crops and cereal consumption have had a vital role in Mankind's history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensively studied, while non-celiac gluten sensitivity is a relatively novel clinical entity, believed to be closely related to other gastrointestinal functional syndromes. The diagnosis of celiac disease and wheat allergy is based on a combination of findings from the patient's clinical history and specific tests, including serology and duodenal biopsies in case of celiac disease, or laboratory and functional assays for wheat allergy. On the other hand, non-celiac gluten sensitivity is still mainly a diagnosis of exclusion, in the absence of clear-cut diagnostic criteria. A multimodal pragmatic approach combining findings from the clinical history, symptoms, serological and histological tests is required in order to reach an accurate diagnosis. A thorough knowledge of the differences and overlap in clinical presentation among gluten-related disorders, and between them and other gastrointestinal disorders, will help clinicians in the process of differential diagnosis.

  14. Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity

    Science.gov (United States)

    Elli, Luca; Branchi, Federica; Tomba, Carolina; Villalta, Danilo; Norsa, Lorenzo; Ferretti, Francesca; Roncoroni, Leda; Bardella, Maria Teresa

    2015-01-01

    Cereal crops and cereal consumption have had a vital role in Mankind’s history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensively studied, while non-celiac gluten sensitivity is a relatively novel clinical entity, believed to be closely related to other gastrointestinal functional syndromes. The diagnosis of celiac disease and wheat allergy is based on a combination of findings from the patient’s clinical history and specific tests, including serology and duodenal biopsies in case of celiac disease, or laboratory and functional assays for wheat allergy. On the other hand, non-celiac gluten sensitivity is still mainly a diagnosis of exclusion, in the absence of clear-cut diagnostic criteria. A multimodal pragmatic approach combining findings from the clinical history, symptoms, serological and histological tests is required in order to reach an accurate diagnosis. A thorough knowledge of the differences and overlap in clinical presentation among gluten-related disorders, and between them and other gastrointestinal disorders, will help clinicians in the process of differential diagnosis. PMID:26109797

  15. Relative effects of cognitive and behavioral therapies on generalized anxiety disorder, social anxiety disorder and panic disorder: A meta-analysis.

    Science.gov (United States)

    Cuijpers, Pim; Gentili, Claudio; Banos, Rosa M; Garcia-Campayo, Javier; Botella, Cristina; Cristea, Ioana A

    2016-10-01

    Although cognitive and behavioral therapies are effective in the treatment of anxiety disorders, it is not clear what the relative effects of these treatments are. We conducted a meta-analysis of trials comparing cognitive and behavioral therapies with a control condition, in patients with social anxiety disorder (SAD), generalized anxiety disorder (GAD) and panic disorder. We included 42 studies in which generic measures of anxiety were used (BAI, HAMA, STAI-State and Trait). Only the effects of treatment for panic disorder as measured on the BAI (13.33 points; 95% CI: 10.58-16.07) were significantly (p=0.001) larger than the effect sizes on GAD (6.06 points; 95% CI: 3.96-8.16) and SAD (5.92 points; 95% CI: 4.64-7.20). The effects remained significant after adjusting for baseline severity and other major characteristics of the trials. The results should be considered with caution because of the small number of studies in many subgroups and the high risk of bias in most studies.

  16. Clinician experiences assessing work disability related to mental disorders

    NARCIS (Netherlands)

    Dewa, C.S.; Hees, H.; Trojanowski, L.; Schene, A.H.

    2015-01-01

    OBJECTIVE: Medical certification is one of the basic administrative mechanisms used by social policies aimed at income protection. The assessment of work disability is central to the income protection application. Yet, there is evidence suggesting that determining work disability related to mental

  17. Relation between obesity, lipid profile, leptin and atopic disorders in ...

    African Journals Online (AJOL)

    EL-HAKIM

    relation of birth weight and breast feeding to both obesity and atopy. Methods: Forty ... atopy: Serum leptin was higher in obese children when compared to control group more in non ..... body mass index and allergy in teen age girls in. Taiwan.

  18. Obsessive compulsive and related disorders: comparing DSM-5 and ICD-11.

    Science.gov (United States)

    Marras, Anna; Fineberg, Naomi; Pallanti, Stefano

    2016-08-01

    Obsessive-compulsive disorder (OCD) has been recognized as mainly characterized by compulsivity rather than anxiety and, therefore, was removed from the anxiety disorders chapter and given its own in both the American Psychiatric Association (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and the Beta Draft Version of the 11th revision of the World Health Organization (WHO) International Classification of Diseases (ICD-11). This revised clustering is based on increasing evidence of common affected neurocircuits between disorders, differently from previous classification systems based on interrater agreement. In this article, we focus on the classification of obsessive-compulsive and related disorders (OCRDs), examining the differences in approach adopted by these 2 nosological systems, with particular attention to the proposed changes in the forthcoming ICD-11. At this stage, notable differences in the ICD classification are emerging from the previous revision, apparently converging toward a reformulation of OCRDs that is closer to the DSM-5.

  19. Health disorders related to learning the welding trade: assessment of approaches to risk communication

    Directory of Open Access Journals (Sweden)

    Clarice Alves Bonow

    2014-01-01

    Full Text Available OBJECTIVE: to assess the identification of health disorders as self-reported by apprentices of welding and to analyze the strength of the relationship between age and time of experience with self-reported health disorders before and after a socio-environmental nursing intervention. METHOD: this quasi-experimental, non-randomized, before-and-after study was conducted with 86 welding apprentices from a private entity. RESULTS: the results show a significant difference for the pre- and post-test means and an increase in the post-test mean score for the cardiovascular, respiratory and cutaneous systems. There was also a negative correlation between the apprentices' ages and the identification of health disorders. CONCLUSION: the socio-environmental nursing intervention enabled obtaining information on health disorders related to welding. In turn, such information enabled the apprentices to assess information and self-report health disorders.

  20. A study of process induced voids in resistance welding of thermoplastic composites

    OpenAIRE

    Shi, H.; Fernandez Villegas, I.; Bersee, H.E.N.

    2015-01-01

    Void formation in resistance welding of woven fabric reinforced thermoplastic composites was investigated. Void contents were measured using optical microscopy and digital image process. Un-even void distributions were observed in the joints, and more voids were found in the middle of the joints than the edges. A higher welding pressure was shown to help reduce the void generation. The mechanisms of void formation, in particular fibre de-compaction induced voids and residual moisture induced ...

  1. Mitochondrial sirtuins as therapeutic targets for age-related disorders.

    Science.gov (United States)

    Shih, Jennifer; Donmez, Gizem

    2013-03-01

    Sirtuins are a class of histone deacetylases that have a wide range of regulatory roles in the cell. Three sirtuins, SIRT3 to SIRT5, localize to and function within the mitochondria. Mitochondrial dysfunction is thought to be the underlying mechanism of several age-related diseases, such as metabolic syndrome, cancer, and neurodegeneration. This review examines current evidence that mitochondrial sirtuins are involved in regulating mitochondrial function and pathogenesis.

  2. Behaviour of voids in a shear field

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2009-01-01

    to a plane connecting the ends of the micro-crack is used as an approximate representation of contact stresses during frictionless sliding. In a previous study of the same problem the author applied hydrostatic pressure inside the nearly closed micro-crack to approximate contact conditions. The transverse...... surface loads used in the present analyses avoid the tendency to unrealistically elongate the voids. It is found that even though the model applied here gives significantly later occurrence of a maximum overall shear stress than that found by using hydrostatic pressure, the present model does predict...... a maximum in all the cases analyzed and thus illustrates the micro-mechanism leading to failure of the material by localization of plastic flow....

  3. Formation of Voids from Negative Density Perturbations

    Science.gov (United States)

    de Araujo, J. C. N.; Opher, R.

    1990-11-01

    RESUMEN. Se estudia la formaci6n de huecos a partir de un espectro negativo de perturbaciones, tomando en cuenta la expansi6n del Universo, arrastre por fotones, enfriamiento por fotones, fotoionizaci6n, ioniza- ci6n colisional, enfriamiento Lyman a y la formaci6n y enfriamiento de moleculas H2. Nuestros resultados predicen la existencia de regiones 1/10 de Ia densidad promedio para regiones de masa lO - 1O10M . ABSTRACT. In the present paer we study the formation of voids from a negative spectrum of perturbations taking into account the expansion of the Universe, photon-drag, photon-cooling, photoionization, collisional ionization, Lyman a cooling and the formation and cooling of 112 molecules. Our results predict the existence of regions 1/10 the average density for regions of mass 1O - 1O10M@ : CLUSTERS-GALAXIES - COSMOLOGY

  4. A study of the risk for Alzheimer’s disease in first-degree relatives of patients with affective disorders

    Institute of Scientific and Technical Information of China (English)

    徐文炜

    2013-01-01

    Objective To investigate the prevalence of Alzheimer’s disease (AD) in first-degree relatives of patients with affective disorders,and to evaluate the risk of AD in firstdegree relatives of the patients with affective disorders.Methods Patients with affective disorders meeting"DSM-Ⅳ-TR"criteria (affective disorders group) and their healthy spouses (conrol group) were recruited in this study (n=109 each) .The first-degree relatives in-

  5. Maternal anxiety versus depressive disorders: specific relations to infants' crying, feeding and sleeping problems.

    Science.gov (United States)

    Petzoldt, J; Wittchen, H-U; Einsle, F; Martini, J

    2016-03-01

    Maternal depression has been associated with excessive infant crying, feeding and sleeping problems, but the specificity of maternal depression, as compared with maternal anxiety remains unclear and manifest disorders prior to pregnancy have been widely neglected. In this prospective longitudinal study, the specific associations of maternal anxiety and depressive disorders prior to, during and after pregnancy and infants' crying, feeding and sleeping problems were investigated in the context of maternal parity. In the Maternal Anxiety in Relation to Infant Development (MARI) Study, n = 306 primiparous and multiparous women were repeatedly interviewed from early pregnancy until 16 months post partum with the Composite International Diagnostic Interview for Women (CIDI-V) to assess DSM-IV anxiety and depressive disorders. Information on excessive infant crying, feeding and sleeping problems was obtained from n = 286 mothers during postpartum period via questionnaire and interview (Baby-DIPS). Findings from this study revealed syndrome-specific risk constellations for maternal anxiety and depressive disorders as early as prior to pregnancy: Excessive infant crying (10.1%) was specifically associated with maternal anxiety disorders, especially in infants of younger and lower educated first-time mothers. Feeding problems (36.4%) were predicted by maternal anxiety (and comorbid depressive) disorders in primiparous mothers and infants with lower birth weight. Infant sleeping problems (12.2%) were related to maternal depressive (and comorbid anxiety) disorders irrespective of maternal parity. Primiparous mothers with anxiety disorders may be more prone to anxious misinterpretations of crying and feeding situations leading to an escalation of mother-infant interactions. The relation between maternal depressive and infant sleeping problems may be better explained by a transmission of unsettled maternal sleep to the fetus during pregnancy or a lack of daily

  6. Disordered Eating and Health-Related Quality of Life in Overweight and Obese Children

    Science.gov (United States)

    Lim, Crystal S.; Clifford, Lisa M.; Janicke, David M.

    2014-01-01

    Objectives To examine disordered eating and associations with health-related quality of life (HRQOL) in rural overweight/obese (OW/OB) children. Methods Cross-sectional analyses were conducted with 272 rural OW/OB children aged 8–12 years (M = 10.36; SD = 1.39). Child anthropometrics, demographics, disordered eating attitudes, unhealthy weight control behaviors (UWCBs), and HRQOL were measured. Relationships between these variables were analyzed using bootstrapped multiple linear regressions. Results Clinically significant disordered eating attitudes were endorsed by 17% of the sample, and the majority endorsed UWCBs. Disordered eating attitudes and weight status were the most common predictors of HRQOL. Disordered eating attitudes and UWCBs were negatively related to emotional HRQOL but were unrelated to social, school, or physical HRQOL. Conclusions Disordered eating is a serious and relevant problem in OW/OB children living in rural areas and may be indicative of impairments in emotional functioning. Early intervention may reduce the risk for eating disorders and associated negative sequelae. PMID:24676798

  7. Partial discharge patterns and surface deterioration in voids in filled and unfilled epoxy

    DEFF Research Database (Denmark)

    Holbøll, Joachim; Henriksen, Mogens

    1992-01-01

    Results are presented from analyses of pulses from partial discharges (PDs) in single spherical voids in filled and unfilled epoxy plastic and related to the observed surface deterioration. The filler types used were dolomite, alumina, and silica. Long-time aging tests including pulse phase...

  8. Influence of bulk dielectric polarization and void geometry upon PD transients

    DEFF Research Database (Denmark)

    McAllister, Iain Wilson; Crichton, George C

    1999-01-01

    The induced charge arising from a partial discharge consists of a component associated with the actual space charge in the void, and one related to changes in the polarization of the bulk dielectric. These changes are brought about by the field produced by the space charge. The influence of the v...

  9. Influence of bulk dielectric polarization upon partial discharge transients: Effect of void geometry and orientation

    DEFF Research Database (Denmark)

    McAllister, Iain Wilson; Crichton, G.C.

    2005-01-01

    The induced charge arising from a partial discharge consists of 2 components. One is associated with the actual space charge in the void. The other is related to changes in the polarization of the bulk dielectric. These changes are a direct consequence of the field produced by the space charge. T...

  10. High Frequency Stimulation of the Pelvic Nerve Inhibits Urinary Voiding in Anesthetized Rats

    Directory of Open Access Journals (Sweden)

    Jonathan J. Crook

    2017-08-01

    Full Text Available Urge Urinary Incontinence: “a sudden and uncontrollable desire to void which is impossible to defer” is extremely common and considered the most bothersome of lower urinary tract conditions. Current treatments rely on pharmacological, neuromodulatory, and neurotoxicological approaches to manage the disorder, by reducing the excitability of the bladder muscle. However, some patients remain refractory to treatment. An alternative approach would be to temporarily suppress activity of the micturition control circuitry at the time of need i.e., urgency. In this study we investigated, in a rat model, the utility of high frequency pelvic nerve stimulation to produce a rapid onset, reversible suppression of voiding. In urethane-anesthetized rats periodic voiding was induced by continuous infusion of saline into the bladder whilst recording bladder pressure and electrical activity from the external urethral sphincter (EUS. High frequency (1–3 kHz, sinusoidal pelvic nerve stimulation initiated at the onset of the sharp rise in bladder pressure signaling an imminent void aborted the detrusor contraction. Urine output was suppressed and tone in the EUS increased. Stimulating the right or left nerve was equally effective. The effect was rapid in onset, reversible, and reproducible and evoked only minimal “off target” side effects on blood pressure, heart rate, respiration, uterine pressure, or rectal pressure. Transient contraction of abdominal wall was observed in some animals. Stimulation applied during the filling phase evoked a small, transient rise in bladder pressure and increased tonic activity in the EUS, but no urine output. Suppression of micturition persisted after section of the contralateral pelvic nerve or after ligation of the nerve distal to the electrode cuff on the ipsilateral side. We conclude that high frequency pelvic nerve stimulation initiated at the onset of an imminent void provides a potential means to control urinary

  11. Predicting borderline personality disorder symptoms in adolescents from childhood physical and relational aggression, depression, and attention-deficit/hyperactivity disorder.

    Science.gov (United States)

    Vaillancourt, Tracy; Brittain, Heather L; McDougall, Patricia; Krygsman, Amanda; Boylan, Khrista; Duku, Eric; Hymel, Shelley

    2014-08-01

    Developmental cascade models linking childhood physical and relational aggression with symptoms of depression and attention-deficit/hyperactivity disorder (ADHD; assessed at ages 10, 11, 12, 13, and 14) to borderline personality disorder (BPD) features (assessed at age 14) were examined in a community sample of 484 youth. Results indicated that, when controlling for within-time covariance and across-time stability in the examination of cross-lagged relations among study variables, BPD features at age 14 were predicted by childhood relational aggression and symptoms of depression for boys, and physical and relational aggression, symptoms of depression, and symptoms of ADHD for girls. Moreover, for boys BPD features were predicted from age 10 ADHD through age 12 depression, whereas for girls the pathway to elevated BPD features at age 14 was from depression at age 10 through physical aggression symptoms at age 12. Controlling for earlier associations among variables, we found that for girls the strongest predictor of BPD features at age 14 was physical aggression, whereas for boys all the risk indicators shared a similar predictive impact. This study adds to the growing literature showing that physical and relational aggression ought to be considered when examining early precursors of BPD features.

  12. Effectiveness of Cognitive Behavioral Group Therapy for Treatment of Substance-Related Disorders: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Zeynep Erdogan Yildirim

    2016-03-01

    Full Text Available This study aims to review empirical studies that were used to evaluate the effectiveness of cognitive-behavioral group therapy programs for the treatment of substance-related disorders. Articles in English and Turkish that were published between the years of 2000 and 2015 (January have been screened in national and international databases. Studies that consisted nicotine addicts in sample and that group therapies that not based on cognitive behavioral group therapy approach were excluded. The remaining 36 studies were introduced in the context of method and therapy character-istics, pre / post treatment and follow up results. Consequently, it is understood that cognitive behavioral group therapies for substance- related disorders are effective in decreasing the symptoms of the disorders and recurrence and/or comorbid disorders (anxiety, depression etc. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2016; 8(Supplement 1: 108-128

  13. Anxiety Sensitivity and Its Factors in Relation to Generalized Anxiety Disorder among Adolescents.

    Science.gov (United States)

    Knapp, Ashley A; Blumenthal, Heidemarie; Mischel, Emily R; Badour, Christal L; Leen-Feldner, Ellen W

    2016-02-01

    Anxiety psychopathology, one of the most prevalent classes of disorder among youth, is linked to detrimental outcomes. Accordingly, identifying factors that influence vulnerability to anxiety disorders is important. One promising factor, given emerging evidence for its transdiagnostic nature, is anxiety sensitivity (AS); however, relatively little is known about the linkage between AS and indicators of generalized anxiety disorder (GAD), particularly among youth. The aim of the current investigation was to address this gap in the literature using a community-based sample of adolescents aged 10-17 years (n = 165; M age  = 14.49 years, SD = 2.26). Results indicated global AS and the AS-physical concerns dimension were significantly associated with worry, generalized anxiety symptoms, and GAD diagnosis assessed via a structured clinical interview, above and beyond key theoretically-relevant covariates. These findings add to a growing body of work underscoring the relevance of AS for multiple types of anxiety-related disorders among youth.

  14. Eponyms related to genetic disorders associated with gingival enlargement; part II

    Directory of Open Access Journals (Sweden)

    Nora Mohammed Al-Aboud

    2015-01-01

    Full Text Available There are genetic disorders associated with gingival enlargement. In our part I, we reviewed the eponyms linked to Hereditary Gingival Fibromatosis (HGF [1]. Historical Article How to cite this article: Al Aboud A, Al-Aboud NM, Barnawi H, Al Hakami A. Eponyms related to genetic disorders associated with gingival enlargement: Part II. Our Dermatol Online. 2015;6(1:114-117. Submission: 27.05.2013; Acceptance: 21.09.2014 DOI: 10.7241/ourd.20151.32 In this part II of this review, we are going to shed some light on eponyms linked to groups of genetic disorders which may feature gingival enlargement.

  15. Relations among Perceived Control over Anxiety-Related Events, Worry, and Generalized Anxiety Disorder in a Sample of Adolescents

    Science.gov (United States)

    Frala, Jamie L.; Leen-Feldner, Ellen W.; Blumenthal, Heidemarie; Barreto, Carolina C.

    2010-01-01

    This study examined the associations among perceived control over anxiety-related events, worry, and both symptoms and diagnoses of generalized anxiety disorder (GAD). The sample was comprised of 140 adolescents (60 girls) between the ages of 10 and 17 years (M[subscript age] = 14.6 years; SD = 2.25) recruited from the general community. Findings…

  16. Mechanisms of comorbidity, continuity, and discontinuity in anxiety-related disorders

    OpenAIRE

    McNaughton, N; Corr, P J

    2016-01-01

    We discuss comorbidity, continuity, and discontinuity of anxiety-related disorders from the perspective of a two-dimensional neuropsychology of fear (threat avoidance) and anxiety (threat approach). Pharmacological dissection of the "neurotic" disorders justifies both a categorical division between fear and anxiety and a subdivision of each mapped to a hierarchy of neural modules that process different immediacies of threat. It is critical that each module can generate normal responses, sympt...

  17. Taylor-plasticity-based analysis of length scale effects in void growth

    KAUST Repository

    Liu, Junxian

    2014-09-25

    We have studied the void growth problem by employing the Taylor-based strain gradient plasticity theories, from which we have chosen the following three, namely, the mechanism-based strain gradient (MSG) plasticity (Gao et al 1999 J. Mech. Phys. Solids 47 1239, Huang et al 2000 J. Mech. Phys. Solids 48 99-128), the Taylor-based nonlocal theory (TNT; 2001 Gao and Huang 2001 Int. J. Solids Struct. 38 2615) and the conventional theory of MSG (CMSG; Huang et al 2004 Int. J. Plast. 20 753). We have addressed the following three issues which occur when plastic deformation at the void surface is unconstrained. (1) Effects of elastic deformation. Elasticity is essential for cavitation instability. It is therefore important to guarantee that the gradient term entering the Taylor model is the effective plastic strain gradient instead of the total strain gradient. We propose a simple elastic-plastic decomposition method. When the void size approaches the minimum allowable initial void size related to the maximum allowable geometrically necessary dislocation density, overestimation of the flow stress due to the negligence of the elastic strain gradient is on the order of lεY/R0 near the void surface, where l, εY and R0 are, respectively, the intrinsic material length scale, the yield strain and the initial void radius. (2) MSG intrinsic inconsistency, which was initially mentioned in Gao et al (1999 J. Mech. Phys. Solids 47 1239) but has not been the topic of follow-up studies. We realize that MSG higher-order stress arises due to the linear-strain-field approximation within the mesoscale cell with a nonzero size, lε. Simple analysis shows that within an MSG mesoscale cell near the void surface, the difference between microscale and mesoscale strains is on the order of (lε/R0)2, indicating that when lε/R0 ∼ 1.0, the higher-order stress effect can make the MSG result considerably different from the TNT or CMSG results. (3) Critical condition for cavitation instability

  18. Potential-Dependent Generalized Einstein Relation in Disordered Organic Semiconductors

    Institute of Scientific and Technical Information of China (English)

    LU Xiao-Hong; SUN Jiu-Xun; GUO Yang; ZHANG Da

    2009-01-01

    The generalized Einstein relation (GER) is extended to consider the potential energy of carriers in an electric field (PDGER).It can be equivalently seen as the GER having position-dependent Fermi energy,and implies the organic semiconductor is in non-equilibrium under an electric field.The distribution of the carrier density with position is solved for two polymer layers.The numerical results are used to evaluate the PDGER.It is shown that the ratio of diffusion coefficient to mobility,μ/D,increases with Fermi energy and decreases with carrier density.The PDGER gives non-traditional values for the two polymer layers;the value of μ/D is small near the surface,and slightly increases as the position departs from the surface.

  19. Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive–compulsive disorder as an example of overlapping clinical and genetic heterogeneity

    Science.gov (United States)

    Murphy, Dennis L.; Moya, Pablo R.; Fox, Meredith A.; Rubenstein, Liza M.; Wendland, Jens R.; Timpano, Kiara R.

    2013-01-01

    Individuals with obsessive–compulsive disorder (OCD) have also been shown to have comorbid lifetime diagnoses of major depressive disorder (MDD; rates greater than 70%), bipolar disorder (rates greater than 10%) and other anxiety disorders (e.g. panic disorder, post-traumatic stress disorder (PTSD)). In addition, overlap exists in some common genetic variants (e.g. the serotonin transporter gene (SLC6A4), the brain-derived neurotrophic factor (BDNF) gene), and rare variants in genes/chromosomal abnormalities (e.g. the 22q11 microdeletion syndrome) found across the affective/anxiety disorder spectrums. OCD has been proposed as a possible independent entity for DSM-5, but by others thought best retained as an anxiety disorder subtype (its current designation in DSM-IV), and yet by others considered best in the affective disorder spectrum. This review focuses on OCD, a well-studied but still puzzling heterogeneous disorder, regarding alterations in serotonergic, dopaminergic and glutamatergic neurotransmission in addition to other systems involved, and how related genes may be involved in the comorbidity of anxiety and affective disorders. OCD resembles disorders such as depression, in which gene × gene interactions, gene × environment interactions and stress elements coalesce to yield OC symptoms and, in some individuals, full-blown OCD with multiple comorbid disorders. PMID:23440468

  20. Psychomotor development in infants with Prader-Willi syndrome and associations with sleep-related breathing disorders.

    NARCIS (Netherlands)

    Festen, D.A.; Wevers, M.; Weerd, A.W. de; Bossche, R.A. van den; Duivenvoorden, H.J.; Otten, B.J.; Wit, J.M.; Hokken-Koelega, A.C.

    2007-01-01

    Prader-Willi syndrome (PWS) is a neurogenetic disorder with hypotonia, psychomotor delay, obesity, short stature, and sleep-related breathing disorders. The aim of this study was to evaluate the association between psychomotor development and sleep-related breathing disorders in PWS infants. Bayley

  1. Measuring the growth rate of structure around cosmic voids

    Science.gov (United States)

    Hawken, A. J.; Michelett, D.; Granett, B.; Iovino, A.; Guzzo, L.

    2016-10-01

    Using an algorithm based on searching for empty spheres we identified 245 voids in the VIMOS Public Extragalactic Redshift Survey (VIPERS). We show how by modelling the anisotropic void-galaxy cross correlation function we can probe the growth rate of structure.

  2. An Interacting Galaxy System along a Filament in a Void

    NARCIS (Netherlands)

    Beygu, B.; Kreckel, K.; van de Weijgaert, R.; van der Hulst, J. M.; van Gorkom, J. H.

    2013-01-01

    Cosmological voids provide a unique environment for the study of galaxy formation and evolution. The galaxy population in their interiors has properties significantly different from average field galaxies. As part of our Void Galaxy Survey (VGS), we have found a system of three interacting galaxies

  3. A Cosmic Void Catalog of SDSS DR12 BOSS Galaxies

    CERN Document Server

    Mao, Qingqing; Scherrer, Robert J; Scoccimarro, Roman; Tinker, Jeremy L; McBride, Cameron K; Neyrinck, Mark C; Schneider, Donald P; Pan, Kaike; Bizyaev, Dmitry; Malanushenko, Elena; Malanushenko, Viktor

    2016-01-01

    We present a cosmic void catalog using the large-scale structure galaxy catalog from the Baryon Oscillation Spectroscopic Survey (BOSS). This galaxy catalog is part of the Sloan Digital Sky Survey (SDSS) Data Release 12 and is the final catalog of SDSS-III. We take into account the survey boundaries, masks, and angular and radial selection functions, and apply the ZOBOV void finding algorithm to the galaxy catalog. After making quality cuts to ensure that the voids represent real underdense regions, we identify 1228 voids with effective radii spanning the range 20-100Mpc/h and with central densities that are, on average, 30% of the mean sample density. We discuss the basic statistics of voids, such as their size and redshift distributions, and measure the radial density profile of the voids via a stacking technique. In addition, we construct mock void catalogs from 1000 mock galaxy catalogs, and find that the properties of BOSS voids are in good agreement with those in the mock catalogs. We compare the stella...

  4. Tensor anisotropy as a tracer of cosmic voids

    CERN Document Server

    Bustamante, Sebastian

    2015-01-01

    We present a new method to find voids in cosmological simulations based on the tidal and the velocity shear tensors definitions of the cosmic web. We use the fractional anisotropy (FA) computed from the eigenvalues of each web scheme as a void tracer. We identify voids using a watershed transform based on the local minima of the FA field without making any assumption on the shape or structure of the voids. We test the method on the Bolshoi simulation and report on the abundance and radial averaged profiles for the density, velocity and fractional anisotropy. We find that voids in the velocity shear web are smaller than voids in the tidal web, with a particular overabundance of very small voids in the inner region of filaments/sheets. We classify voids as subcompensated/overcompansated depending on the absence/presence of an overdense matter ridge in their density profile, finding that close to $65\\%$ and $35\\%$ of the total population are classified into each category, respectively. Finally, we find evidence ...

  5. The relationship between void waves and flow regime transition

    Energy Technology Data Exchange (ETDEWEB)

    Lahey, R.T. Jr.; Drew, D.A.; Kalkach-Navarro, S.; Park, J.W.

    1992-12-31

    The results of an extensive experimental and analytical study on the relationship between void waves and flow regime transition are presented, in particular, the bubbly/slug flow regime transition. It is shown that void wave instability signals a flow regime transition.

  6. Voided stain on paper method for analysis of mouse urination.

    Science.gov (United States)

    Sugino, Y; Kanematsu, A; Hayashi, Y; Haga, H; Yoshimura, N; Yoshimura, K; Ogawa, O

    2008-01-01

    To evaluate the usefulness of a quantification method using filter paper for analyzing minute voided urine of the mouse. Voided stain on paper (VSOP) method; the correlation between area of stained spot on a filter paper and amount of applied liquid was calculated. Voiding behavior of the mice was analyzed by placing the animal above the same filter paper and recording voided time and area over 2 hr. The usefulness of the VSOP method was tested in analysis of the voiding behavior of five female 7-week-old ddY mice treated with cyclophosphamide (CPM, 150 mg/kg, intraperitoneally) and five control ones, in comparison with the histology of CPM-induced cystitis. Further, the voided volume of male and female ddY mouse ranging from 2 to 13 weeks was assessed. There was a linear correlation between liquid volume and stained area on the filter paper (y = 16.472x - 22.411, R(2) = 0.9981). Between control mice and those with histologically proven CPM cystitis, there was a significant difference in voided volume (362.7 +/- 51.9 and 127.8 +/- 100.0 microl, VSOP method is a useful tool for evaluating voiding behavior of the mouse, including those with small bladder capacity.

  7. Voids and the Cosmic Web: cosmic depression & spatial complexity

    NARCIS (Netherlands)

    van de Weygaert, Rien; Shandarin, S.; Saar, E.; Einasto, J.

    2016-01-01

    Voids form a prominent aspect of the Megaparsec distribution of galaxies and matter. Not only do theyrepresent a key constituent of the Cosmic Web, they also are one of the cleanest probesand measures of global cosmological parameters. The shape and evolution of voids are highly sensitive tothe natu

  8. STRESS CONCENTRATION DUE TO A SPHERICAL VOID UNDER HERTZIAN CONTACT

    Directory of Open Access Journals (Sweden)

    Stelian ALACI,

    2010-06-01

    Full Text Available The present paper presents the method of estimating the stress concentrator effect of a spherical void from an elastic half-space. An essential part consists in estimation of FEM error by finding the contact pressure from half-plane using an analytical method. Next, the stress concentrator effect of the same void, except for placed into elastic space, is found.

  9. High gain durable anti-reflective coating with oblate voids

    Energy Technology Data Exchange (ETDEWEB)

    Maghsoodi, Sina; Brophy, Brenor L.; Colson, Thomas E.; Gonsalves, Peter R.; Abrams, Ze' ev

    2016-06-28

    Disclosed herein are single layer transparent coatings with an anti-reflective property, a hydrophobic property, and that are highly abrasion resistant. The single layer transparent coatings contain a plurality of oblate voids. At least 1% of the oblate voids are open to a surface of the single layer transparent coatings.

  10. The Aspen-Amsterdam void finder comparison project

    NARCIS (Netherlands)

    Colberg, Joerg M.; Pearce, Frazer; Foster, Caroline; Platen, Erwin; Brunino, Riccardo; Neyrinck, Mark; Basilakos, Spyros; Fairall, Anthony; Feldman, Hume; Gottloeber, Stefan; Hahn, Oliver; Hoyle, Fiona; Mueller, Volker; Nelson, Lorne; Plionis, Manolis; Porciani, Cristiano; Shandarin, Sergei; Vogeley, Michael S.; van de Weygaert, Rien

    2008-01-01

    Despite a history that dates back at least a quarter of a century, studies of voids in the large-scale structure of the Universe are bedevilled by a major problem: there exist a large number of quite different void-finding algorithms, a fact that has so far got in the way of groups comparing their

  11. Locating voids beneath pavement using pulsed electromagnetic waves

    Science.gov (United States)

    Steinway, W. J.; Echard, J. D.; Luke, C. M.

    1981-11-01

    The feasibility of using pulsed electromagnetic wave technology for locating and sizing voids beneath reinforced and nonreinforced portland cement concrete pavements is determined. The data processing techniques developed can be implemented to provide information for void depth and sizing to + or - 1/2 in. and spatial location within + or - 6 in. A very short pulse radar directly connected to a microcomputer was chosen as the equipment necessary to obtain measurements. This equipment has the required accuracy and reliability, and is a cost effective solution for the void locating problem. The radar provides a signal return from voids that has unique characteristics that can be examined to provide information regarding the location, depth, and shape of the void. The microcomputer provides a means of real time processing to extract the information from the radar signal return and record the results. Theoretical modeling of signal returns from voids led to suitable techniques for locating and sizing voids beneath the pavement. Analysis and application of these techniques to radar measurements verified the theoretical predictions that radar can be used to determine the location, size, and shape of actual voids.

  12. Warmth Elevating the Depths: Shallower Voids with Warm Dark Matter

    CERN Document Server

    Yang, Lin F; Aragon-Calvo, Miguel A; Silk, Joseph

    2014-01-01

    Warm dark matter (WDM) has been proposed as an alternative to cold dark matter (CDM), to resolve issues such as the apparent lack of satellites around the Milky Way. Even if WDM is not the answer to observational issues, it is essential to constrain the nature of the dark matter. The effect of WDM on haloes has been extensively studied, but the small-scale initial smoothing in WDM also affects the present-day cosmic web and voids. It suppresses the cosmic "sub-web" inside voids, and the formation of both void haloes and subvoids. In N-body simulations run with different assumed WDM masses, we identify voids with the zobov algorithm, and cosmic-web components with the origami algorithm. As dark-matter warmth increases, the initial-conditions smoothing increases, and the number of voids and subvoids is suppressed. Also, void density profiles change, their shapes become flatter inside the void radius, while edges of the voids remain unchanged. Also, filaments and walls become cleaner, as the sub-structures in be...

  13. Avoidant Coping and Treatment Outcome in Rape-Related Posttraumatic Stress Disorder

    Science.gov (United States)

    Leiner, Amy S.; Kearns, Megan C.; Jackson, Joan L.; Astin, Millie C.; Rothbaum, Barbara O.

    2012-01-01

    Objective: This study investigated the impact of avoidant coping on treatment outcome in rape-related posttraumatic stress disorder (PTSD). Method: Adult women with rape-related PTSD (N = 62) received 9 sessions of prolonged exposure (PE) or eye movement desensitization and reprocessing (EMDR). The mean age for the sample was 34.7 years, and race…

  14. Enhanced priming for trauma-related words predicts posttraumatic stress disorder

    NARCIS (Netherlands)

    Ehring, T.; Ehlers, A.

    2011-01-01

    There is preliminary evidence that enhanced priming for trauma-related cues plays a role in posttraumatic stress disorder (PTSD). A prospective study of 119 motor vehicle accident survivors investigated whether priming for trauma-related stimuli predicts PTSD. Participants completed a modified

  15. Enhanced priming for trauma-related words predicts posttraumatic stress disorder

    NARCIS (Netherlands)

    T. Ehring; A. Ehlers

    2011-01-01

    There is preliminary evidence that enhanced priming for trauma-related cues plays a role in posttraumatic stress disorder (PTSD). A prospective study of 119 motor vehicle accident survivors investigated whether priming for trauma-related stimuli predicts PTSD. Participants completed a modified word-

  16. Work-Family Relations among Mothers of Children with Learning Disorders

    Science.gov (United States)

    Al-Yagon, Michal; Cinamon, Rachel Gali

    2008-01-01

    The study examined conflict and facilitation in work-family relations among working mothers of children with learning disorders (LD) or with typical development. The study also focused on three maternal personal resources (maternal anxious/avoidant attachment security, affect and sense of coherence) as antecedents of these work-family relations,…

  17. Insight in body dysmorphic disorder (BDD) relative to obsessive-compulsive disorder (OCD) and psychotic disorders: Revisiting this issue in light of DSM-5.

    Science.gov (United States)

    Toh, Wei Lin; Castle, David J; Mountjoy, Rachel L; Buchanan, Ben; Farhall, John; Rossell, Susan L

    2017-08-01

    In DSM-5, body dysmorphic disorder (BDD) was reclassified under the obsessive-compulsive and related disorders (OCRDs), but little is known about the nature of BDD beliefs. This study aimed to compare level of insight in BDD and consider related implications for DSM-5 classification. Participants were 27 BDD, 19 obsessive-compulsive disorder (OCD), and 20 psychosis (SZ) participants as well as 42 non-clinical controls (NC), who completed the Brown Assessment of Beliefs Scale (BABS) and Peters Delusions Inventory (PDI). For total (and most individual) BABS items, BDD and SZ participants scored significantly higher than OCD and NC participants. On the PDI, there were significant group differences in number of questions endorsed, with clinical groups scoring significantly higher than the NC group on dimensions of distress and preoccupation, but not conviction. These findings suggest appearance-related concerns in BDD somewhat resemble delusions seen in psychosis (and not OCD), and convey important nosological and therapeutic implications. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Emotional and cognitive social processes are impaired in Parkinson's disease and are related to behavioral disorders.

    Science.gov (United States)

    Narme, Pauline; Mouras, Harold; Roussel, Martine; Duru, Cécile; Krystkowiak, Pierre; Godefroy, Olivier

    2013-03-01

    Parkinson's disease (PD) is associated with behavioral disorders that can affect social functioning but are poorly understood. Since emotional and cognitive social processes are known to be crucial in social relationships, impairment of these processes may account for the emergence of behavioral disorders. We used a systematic battery of tests to assess emotional processes and social cognition in PD patients and relate our findings to conventional neuropsychological data (especially behavioral disorders). Twenty-three PD patients and 46 controls (matched for age and educational level) were included in the study and underwent neuropsychological testing, including an assessment of the behavioral and cognitive components of executive function. Emotional and cognitive social processes were assessed with the Interpersonal Reactivity Index caregiver-administered questionnaire (as a measure of empathy), a facial emotion recognition task and two theory of mind (ToM) tasks. When compared with controls, PD patients showed low levels of empathy (p = .006), impaired facial emotion recognition (which persisted after correction for perceptual abilities) (p = .001), poor performance in a second-order ToM task (p = .008) that assessed both cognitive (p = .004) and affective (p = .03) inferences and, lastly, frequent dysexecutive behavioral disorders (in over 40% of the patients). Overall, impaired emotional and cognitive social functioning was observed in 17% of patients and was related to certain cognitive dysexecutive disorders. In terms of behavioral dysexecutive disorders, social behavior disorders were related to impaired emotional and cognitive social functioning (p = .04) but were independent of cognitive impairments. Emotional and cognitive social processes were found to be impaired in Parkinson's disease. This impairment may account for the emergence of social behavioral disorders. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  19. Dislocation and void segregation in copper during neutron irradiation

    DEFF Research Database (Denmark)

    Singh, Bachu Narain; Leffers, Torben; Horsewell, Andy

    1986-01-01

    High-purity (99. 999%) and fully annealed copper specimens have been irradiated in the DR-3 reactor at Riso to doses of 1 multiplied by 10**2**2 and 5 multiplied by 10**2**2 neutrons (fast)m** minus **2(2 multiplied by 10** minus **3 dpa and 1 multiplied by 10** minus **2 dpa, respectively...... were distributed between these walls. The dislocation walls were practically free of voids and generally had a void-denuded zone along them. The density of dislocations (loops and segments) was very low in the region containing voids (i. e. between the dislocation walls). Even with this low dislocation...... density, the void swelling rate was very high (approximately 2. 5% per dpa). The implications of the segregated distribution of sinks for void formation and growth are briefly discussed....

  20. Alignment of galaxy spins in the vicinity of voids

    CERN Document Server

    Slosar, Anze

    2008-01-01

    We provide limits on the alignment of galaxy orientations with the direction to the void center for galaxies lying near the edges of voids. We locate spherical voids in volume limited samples of galaxies from the Sloan Digital Sky Survey using the HB inspired void finder and investigate the orientation of (color selected) spiral galaxies that are nearly edge-on or face-on. In contrast with previous literature, we find no statistical evidence for departure from random orientations. Expressed in terms of the parameter c, introduced by Lee & Pen to describe the strength of such an alignment, we find that c<0.11(0.13) at 95% (99.7%) confidence limit within a context of a toy model that assumes a perfectly spherical voids with sharp boundaries.