Functions that Protect Escherichia coli from Tightly Bound DNA-Protein Complexes Created by Mutant EcoRII Methyltransferase.

Science.gov (United States)

Henderson, Morgan L; Kreuzer, Kenneth N

2015-01-01

Expression of mutant EcoRII methyltransferase protein (M.EcoRII-C186A) in Escherichia coli leads to tightly bound DNA-protein complexes (TBCs), located sporadically on the chromosome rather than in tandem arrays. The mechanisms behind the lethality induced by such sporadic TBCs are not well studied, nor is it clear whether very tight binding but non-covalent complexes are processed in the same way as covalent DNA-protein crosslinks (DPCs). Using 2D gel electrophoresis, we found that TBCs induced by M.EcoRII-C186A block replication forks in vivo. Specific bubble molecules were detected as spots on the 2D gel, only when M.EcoRII-C186A was induced, and a mutation that eliminates a specific EcoRII methylation site led to disappearance of the corresponding spot. We also performed a candidate gene screen for mutants that are hypersensitive to TBCs induced by M.EcoRII-C186A. We found several gene products necessary for protection against these TBCs that are known to also protect against DPCs induced with wild-type M.EcoRII (after 5-azacytidine incorporation): RecA, RecBC, RecG, RuvABC, UvrD, FtsK, XerCD and SsrA (tmRNA). In contrast, the RecFOR pathway and Rep helicase are needed for protection against TBCs but not DPCs induced by M.EcoRII. We propose that stalled fork processing by RecFOR and RecA promotes release of tightly bound (but non-covalent) blocking proteins, perhaps by licensing Rep helicase-driven dissociation of the blocking M.EcoRII-C186A. Our studies also argued against the involvement of several proteins that might be expected to protect against TBCs. We took the opportunity to directly compare the sensitivity of all tested mutants to two quinolone antibiotics, which target bacterial type II topoisomerases and induce a unique form of DPC. We uncovered rep, ftsK and xerCD as novel quinolone hypersensitive mutants, and also obtained evidence against the involvement of a number of functions that might be expected to protect against quinolones.

Functions that Protect Escherichia coli from Tightly Bound DNA-Protein Complexes Created by Mutant EcoRII Methyltransferase.

Directory of Open Access Journals (Sweden)

Morgan L Henderson

Full Text Available Expression of mutant EcoRII methyltransferase protein (M.EcoRII-C186A in Escherichia coli leads to tightly bound DNA-protein complexes (TBCs, located sporadically on the chromosome rather than in tandem arrays. The mechanisms behind the lethality induced by such sporadic TBCs are not well studied, nor is it clear whether very tight binding but non-covalent complexes are processed in the same way as covalent DNA-protein crosslinks (DPCs. Using 2D gel electrophoresis, we found that TBCs induced by M.EcoRII-C186A block replication forks in vivo. Specific bubble molecules were detected as spots on the 2D gel, only when M.EcoRII-C186A was induced, and a mutation that eliminates a specific EcoRII methylation site led to disappearance of the corresponding spot. We also performed a candidate gene screen for mutants that are hypersensitive to TBCs induced by M.EcoRII-C186A. We found several gene products necessary for protection against these TBCs that are known to also protect against DPCs induced with wild-type M.EcoRII (after 5-azacytidine incorporation: RecA, RecBC, RecG, RuvABC, UvrD, FtsK, XerCD and SsrA (tmRNA. In contrast, the RecFOR pathway and Rep helicase are needed for protection against TBCs but not DPCs induced by M.EcoRII. We propose that stalled fork processing by RecFOR and RecA promotes release of tightly bound (but non-covalent blocking proteins, perhaps by licensing Rep helicase-driven dissociation of the blocking M.EcoRII-C186A. Our studies also argued against the involvement of several proteins that might be expected to protect against TBCs. We took the opportunity to directly compare the sensitivity of all tested mutants to two quinolone antibiotics, which target bacterial type II topoisomerases and induce a unique form of DPC. We uncovered rep, ftsK and xerCD as novel quinolone hypersensitive mutants, and also obtained evidence against the involvement of a number of functions that might be expected to protect against quinolones.

DVD. Aare Ermel soovitab "Meie isade lipud", "Kirjad Iwo Jimalt" / Aare Ermel

Index Scriptorium Estoniae

Ermel, Aare, 1957-2013

2007-01-01

Clint Eastwoodi kaks filmi on Teises Maailmasõjas USA-Jaapani Iwo Jima saarel peetud lahingu teemal. USA poolt vaadatuna - "Meie isade lipud" ("Flags of Our Fathers"), Jaapani poolt - "Kirjad Iwo Jimalt" ("Letters From Iwo Jima") : Ameerika Ühendriigid 2006

Eesti tüübid : meie siin maal / Maris Rosenthal

Index Scriptorium Estoniae

Rosenthal, Maris

2009-01-01

Eesti Rahva Muuseumi ja fotograaf Alar Madissoni projekti "Eesti tüübid" raames valminud fotonäitus "Meie siin maal" Tartus Raadi mõisapargis. Kaasaega dokumenteeriva projekti eesmärgiks oli jäädvustada kõigis Eesti maakondades elavaid eri generatsioonide ja sotsiaalsete rühmade esindajaid ERMi fotokogu täiendamiseks. Meenutusi pildistamistelt 2008. aasta suvel

Nähtamatud elektromagnetlained meie ümber - kas neid peaks kartma? / Ada Maltseva

Index Scriptorium Estoniae

Maltseva, Ada, 1970-

2007-01-01

Vt. ka Linnaleht : Tartu 7. sept., lk. 12-13 pealk. all: Elektromagnetlained meie ümber - kas neid peab kartma? ; Linnaleht : Tallinn : na russkom jazõke 12. sept., lk. 12-13. Füüsika kesklabori spetsialist Jaan Mell räägib elektromagnetlainetest

Riho Unt lühifilmide festivali žüriis

Index Scriptorium Estoniae

2002-01-01

Nukufilmide režissöör on 1.-9.veebruarini Prantsusmaal Clermont-Ferrand'i lühifilmide festivali žürii liige. Tema nukufilmid Saamueli seklustest on valitud festivali eriprogrammi. Võistlusprogrammi kuulub Priit Tenderi joonisfilm "Mont Blanc"

'Seal, kus oleme meie, on muuseum!' ; Eva ja Adele Helsingis / interv. Heie Treier

Index Scriptorium Estoniae

1998-01-01

Elavad skulptuurid Saksamaalt Eva ja Adele etendasid moodsa kunsti muuseumi Kiasma avamisel performance'it 'Seal, kus oleme meie, on muuseum'. Intervjuu kunstnikega. Kunstnikepaarist, nende eesmärgist, millistes maades võetakse neid kergemini vastu, Kiasmast jm

Constitutive homo- and hetero-oligomerization of TbetaRII-B, an alternatively spliced variant of the mouse TGF-beta type II receptor

DEFF Research Database (Denmark)

Krishnaveni, Manda S; Hansen, Jakob Lerche; Seeger, Werner

2006-01-01

, but the oligomerization pattern and dynamics of TbetaRII splice variants in live cells has not been demonstrated thus far. Using co-immunoprecipitation and bioluminescence resonance energy transfer (BRET), we demonstrate that the mouse TbetaRII receptor splice variant TbetaRII-B is capable of forming ligand...

Naiste staatus meie meeles ja igapäevases keeles / Ülle-Marike Papp

Index Scriptorium Estoniae

Papp, Ülle-Marike

2003-01-01

Autor leiab, et inimõiguste sisu on viimase 50 aasta jooksul muutunud ja meie noorel ühiskonnal on raske aru saada, et eksisteerivad naiste inimõigused, mida järjekindlalt rikutakse patriarhaalse ühiskonnakorralduse, mitte konkreetsete meeste poolt

IMPORTANŢA COMUNICĂRII MANAGERIALE ÎN EXERCITAREA FUNCŢIILOR MANAGEMENTULUI

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Viorica CARAUŞ

2016-12-01

Full Text Available În articol sunt prezentate particularităţile specifice comunicării manageriale şi evoluţia acesteia în timp, ca disciplină a managementului. De asemenea, este argumentată dependenţa dintre funcţiile manageriale şi procesul comunicării. Se constată o relaţie de interdependenţă între funcţiile manageriale şi comunicare, concluzionând că procesul comunicaţional ocupă un loc central în sistemul managerial al oricărei întreprinderi. Sunt reflectate câteva abordări noi ce vizează rolu­rile managerului şi importanţa comunicării manageriale în exercitarea respectivelor roluri. THE IMPORTANCE OF MANAGERIAL COMMUNICATION IN THE EXERCISE OF MANAGERIAL FUNCTIONSThis article presents specific features of managerial communicationas a management discipline and its evolution in time. It is also justified the dependence of the management functions and communication process.It can be noted an interdependent relationship between managerial and communication functions, concluding that the communication process is central to the management system of any enterprise. Also in the article are reflected several new approaches that aim the roles of the manager, and the importance of communication in exercising this managerial roles.

Mida teha, et kirikukäsiraamat meie kirikut ei lõhuks? / Thomas-Andreas Põder

Index Scriptorium Estoniae

Põder, Thomas-Andreas, 1976-

2009-01-01

Kirikukäsiraamatu esialgse redaktsiooni esitlus oli meie kirikuelus kahemõtteline sündmus: raamatu trükist ilmumine ja asjaosaliste tänamine oli rõõmustav, selle esitlemine lõpuleviidud tööna kurvastav

Eesti toidulauale võib olla jõudnud saastunud riis / Nastja Pertsjonok

Index Scriptorium Estoniae

Pertsjonok, Nastja

2006-01-01

Tänavu juulis teatas geneetiliselt muundatud taimi tootev firma Bayer CropScience, et USA pikateraline riis on saastunud girma illegaalse eksperimentaalriisiga LL 601, millele pole kunagi riskianalüüsi tehtud

Kuldmunast žürii liikme pilguga / Lylian Meister

Index Scriptorium Estoniae

Meister, Lylian, 1966-

2010-01-01

2010. a. disainiauhinna Bruno žürii liikme kommentaarid kandidaatidele ja jagatud auhindadele. Tootedisaini kategoorias pälvis auhinna Veiko Liisi kilepiima voldik-kann, parimaks disainiprojektiks valiti Maarja Mõtuse jalatsiprojekt "Võru'82", design management'i auhind läks Kadarbiku tallu. Disainiauhinna kandidaatide tööde näitus Arhitektuuri- ja Disainigaleriis 8. okt.-ni, Rotermanni kvartali vanas elevaatorihoones 3. okt.-ni ("100 meetrit disaini")

Mis on meie huvid Euroopa Liidus? / Villu Känd

Index Scriptorium Estoniae

Känd, Villu

2007-01-01

Ilmunud ka: Meie Maa, 4. juuli 2007, lk. 2; Lääne Elu, 5. juuli 2007, lk. 2; Nädaline, 5. juuli 2007, lk. 5; Põhjarannik, 7. juuli 2007, lk. 2; Hiiu Leht, 10. juuli 2007, lk. 2; Severnoje Poberezhje, 10. juuli 2007, lk. 2; Valgamaalane, 12. juuli 2007, lk. 2; Virumaa Teataja, 18. juuli 2007, lk. 11; Oma saar, 18. juuli 2007, lk. 5; Sakala, 19. juuli 2007, lk. 2. Valminud on versioon olulisest poliitikadokumendist, mis võtab kokku Eesti eesmärgid Euroopa Liidus järgnevatel aastatel

Sammaste säraga pole võimalik valgustada meie elu varjukülgi / Janek Nelson

Index Scriptorium Estoniae

Nelson, Janek

2007-01-01

Ilmunud ka: Meie Maa, 8. sept. 2007, lk. 2; Nädaline, 13. sept. 2007, lk. 2; Põhjarannik, 19. sept. 2007, lk. 2; Severnoje Poberezhje, 19. sept. 2007, lk. 2. Rahvaliidu Rapla maakonnaühenduse juht kritiseerib valitsuse tegevust

Meie julgeolek ei ole automaatselt kindlustatud / Juhan Parts

Index Scriptorium Estoniae

Parts, Juhan, 1966-

2004-01-01

Ilmunud ka: Nädaline, 7. sept. 2004, lk. 2; Harjumaa, 7. sept. 2004, lk. 2; Järva Teataja, 7. sept. 2004, lk. 2; Lääne Elu, 7. sept. 2004, lk. 2; Sakala, 7. sept. 2004, lk. 2; Virumaa Teataja, 7. sept. 2004, lk. 7; Pärnu Postimees, 7. sept. 2004, lk. 15; Meie Maa, 7. sept. 2004, lk. 2; Vooremaa, 7. sept. 2004, lk. 2; Koit, 7. sept. 2004, lk. 6; Võrumaa Teataja, 7. sept. 2004, lk. 2; Hiiumaa, 7. sept. 2004, lk. 2. Lihula ausambast, selle sobimatusest rahvusvahelisse konteksti, meedia reageeringust. Minevikukäsitluses ei saa toetuda Teise maailmasõja aegsele Saksa armee mundrile, sest demokraatlikus maailmas samastub see natsismiga, tõdeb peaminister.

Binding proteins for the regulatory subunit (RII-B) of brain cAMP-dependent protein kinase II: isolation and initial characterization of cDNA clones

International Nuclear Information System (INIS)

Bregman, D.B.; Hu, E.; Rubin, C.S.

1987-01-01

In mammalian brain several proteins bind RII-B with high affinity. An example is P75, which co-purifies with RII-B and also complexes Ca 2+ -calmodulin. Thus, RII-B binding proteins (RBPs) might play a role in integrating the Ca 2+ and cAMP signalling pathways in the CNS. In order to study the structure and function of these polypeptides they have isolated cloned cDNAs for RBPs by screening brain λgt11 expression libraries using a functional assay: the binding of 32 P-labeled RII to fusion proteins produced by recombinants expressing RII binding domains. Inserts from rat brain recombinant clones λ7B and λ10B both hybridize to a brain mRNA of 7000 nucleotides. Northern gel analyses indicate that the putative RBP mRNA is also expressed in lung, but not in several other tissues. The λ7B insert was subcloned into the expression plasmid pINIA. A 50 kDa high affinity RII-B binding polypeptide accumulated in E. coli transformed with pINIA-7B. Two RBP cDNAs (λ77, λ100A) have been retrieved from a bovine λgt 11 library using a monoclonal antibody directed against P75 and the binding assay respectively. On Southern blots the insert from λ100A hybridizes to the cDNA insert from clones λ77, suggesting that λ 77 cDNA might contain sequences coding for both an RII binding domain and a P75 epitope. The bovine λ100A insert also hybridizes with the rat λ7B clone indicating that an RII binding domain is conserved in the two species

NOŢIUNEA, IMPORTANŢA ŞI NATURA JURIDICĂ A EXECUTĂRII SILITE

Directory of Open Access Journals (Sweden)

Anatolie BĂNĂRESCU

2015-11-01

Full Text Available Investigaţia abordează instituţia executării silite, care este un proces, o consecutivitate de acte şi fapte materiale, re-glementate de legea pozitivă, îndreptat spre transpunerea în realitatea obiectivă a dispozitivului hotărârii judecătoreşti susceptibile de executare. Executarea silită este ultima fază a procesului civil şi una dintre formele de manifestare a acţiunii civile.NOTION, IMPORTANCE AND JURIDICAL NATURE OF FORCED EXECUTION The investigation deals with the institution of enforcement which is a process, a consecutiveness of material acts and facts regulated by the positive law, headed for their transposition into objective reality of the device of the judicial decision capable of execution. The enforcement is the last phase of the civil process and one of the forms of civil action.

"Sakala" fotograaf pälvis žürii tähelepanu

Index Scriptorium Estoniae

2007-01-01

Eesti Ajalehtede Liidu pressipreemia fotožürii valis välja 2006. a. paremad uudis- ja olemusfotod. Maakonnalehtede parima uudisfoto tiitlile pretendeerivad Peeter Kümmel, Ants Liigus ja Tairo Lutter, parima olemusfoto tiitlile Margus Ansu, Andrus Eesmaa, Ants Liigus ja Tairo Lutter. Võitjad kuulutatakse välja 2. märtsil

ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments.

Science.gov (United States)

Hatakeyama, Shinji; Summermatter, Serge; Jourdain, Marie; Melly, Stefan; Minetti, Giulia C; Lach-Trifilieff, Estelle

2016-01-01

Cachexia affects the majority of patients with advanced cancer and is associated with reduced treatment tolerance, response to therapy, quality of life, and life expectancy. Cachectic patients with advanced cancer often receive anti-cancer therapies against their specific cancer type as a standard of care, and whether specific ActRII inhibition is efficacious when combined with anti-cancer agents has not been elucidated yet. In this study, we evaluated interactions between ActRII blockade and anti-cancer agents in CT-26 mouse colon cancer-induced cachexia model. CDD866 (murinized version of bimagrumab) is a neutralizing antibody against the activin receptor type II (ActRII) preventing binding of ligands such as myostatin and activin A, which are involved in cancer cachexia. CDD866 was evaluated in association with cisplatin as a standard cytotoxic agent or with everolimus, a molecular-targeted agent against mammalian target of rapamycin (mTOR). In the early studies, the treatment effect on cachexia was investigated, and in the additional studies, the treatment effect on progression of cancer and the associated cachexia was evaluated using body weight loss or tumor volume as interruption criteria. Cisplatin accelerated body weight loss and tended to exacerbate skeletal muscle loss in cachectic animals, likely due to some toxicity of this anti-cancer agent. Administration of CDD866 alone or in combination with cisplatin protected from skeletal muscle weight loss compared to animals receiving only cisplatin, corroborating that ActRII inhibition remains fully efficacious under cisplatin treatment. In contrast, everolimus treatment alone significantly protected the tumor-bearing mice against skeletal muscle weight loss caused by CT-26 tumor. CDD866 not only remains efficacious in the presence of everolimus but also showed a non-significant trend for an additive effect on reversing skeletal muscle weight loss. Importantly, both combination therapies slowed down time

Construction schedule delay risk assessment by using combined AHP-RII methodology for an international NPP project

Directory of Open Access Journals (Sweden)

Muhammed Mufazzal Hossen

2015-04-01

The proposed combined AHP-RII methodology is capable of assessing delay risk effectively and efficiently. Decision makers can apply risk informed decision making to avoid unexpected construction delays of NPPs.

UTILITATEA ŞI RELEVANŢA CERCETĂRII PARTICIPATIVE ÎN INVESTIGAREA FENOMENELOR SOCIALE

Directory of Open Access Journals (Sweden)

Anastasia OCERETNÎI

2017-01-01

Full Text Available În acest articol este luată în vizor o nouă paradigmă de cercetare a fenomenelor sociale, care pune accentul pe abor­darea participativă: actorii sociali studiaţi devin membri ai echipelor de cercetare, favorizând cunoaşterea din interior şi aprofundată a problemelor. Cercetarea participativă permite asigurarea autenticităţii, utilităţii şi relevanţei datelor. Astfel, actorul social se transformă din subiect al cercetării în asistent al cercetătorului, care încearcă să închege „puzzle-ul” realităţii în care trăieşte actorul social. În acelaşi timp, cercetarea bazată pe strategii participative implică procese de capacitare a echipelor comunitare. În cadrul articolului sunt analizate pe larg domeniile şi avantajele aplicării strategiei participative în cercetarea fenomenelor sociale, sunt identificate posibilele limite şi particularităţile design-ului cercetării participative, în baza unor exemple concrete.THE UTILITY AND RELEVANCE OF PARTICIPATORY RESEARCH IN INVESTIGATION OF SOCIAL PHENOMENONThis article presents a new paradigm that emphasizes participatory approach: social actors studied become members of research teams, favoring insider knowledge and in depth of problems. This kind of research allows assurance of the authenticity, usefulness and relevance of data. The social actor turns from research subject to assistant researcher who tries to coagulate "puzzle" of social reality in which lives social actor. At the same time research based on participatory strategies involves community team’s empowerment processes and capacity building. In the article are analyzed in detail the advantages and application areas of participative strategy in researching social phenomena, are identified possible limitations and peculiarities of participatory research design, based on concrete examples.

The inhibitory receptor FcgammaRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcgammaRI/III but also by efficient clearance and endocytosis of immune complexes.

NARCIS (Netherlands)

Lent, P.L.E.M. van; Nabbe, K.C.A.M.; Boross, P.; Blom, A.B.; Roth, J.; Holthuysen, A.E.M.; Sloetjes, A.W.; Verbeek, S.; Berg, W.B. van den

2003-01-01

Studies of FcgammaRII-/- mice identified the inhibitory function of this receptor in joint inflammation and cartilage destruction induced with immune complexes (ICs). To extend our insight in the role of FcgammaRII in arthritis, we explored the role of FcgammaRII in the absence of activating

Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability

International Nuclear Information System (INIS)

Yashiro, Masakazu; Hirakawa, Kosei; Boland, C Richard

2010-01-01

Microsatellite instability (MSI) occurs in 15% of colorectal cancers (CRC). The genetic targets for mutation in the MSI phenotype include somatic mutations in the transforming growth factor beta receptor typeII (TGFbetaRII), BAX, hMSH3 and hMSH6. It is not clear how mutations of these genes mediate tumor progression in the MSI pathway, and the temporal sequence of these mutations remains uncertain. In this study, early stage CRCs were examined for frameshift mutations in these target genes, and compared with late stage tumors and CRC cell lines. We investigated 6 CRC cell lines and 71 sporadic CRCs, including 61 early stage cancers and 10 late stage cancers. Mutations of repetitive mononucleotide tracts in the coding regions of TGFbetaRII, BAX, hMSH3, hMSH6, IGFIIR and Fas antigen were identified by direct sequencing. Thirteen (18.3%) of 71 CRC, including 9/61 (14.7%) early stage cancers and 4/10 (40%) late stage cancers, were identified as MSI and analyzed for frameshift mutations. No mutation in the target genes was observed in any of the 9 early stage MSI CRCs. In contrast, frameshift mutations of TGFbetaRII, BAX, hMSH3 and hMSH6 were present in 3/4 late stage MSI tumors. There is a statistical association (p = 0.014) between mutation in any one gene and tumor stage. TGFbetaRII, BAX, hMSH3 and hMSH6 mutations are relatively late events in the genesis of MSI CRCs. The frameshift mutations in these target genes might mediate progression from early to late stage cancer, rather than mediating the adenoma to carcinoma transition

Utilization of SA-gal as clearing agent in pre-targeting RII of colon carcinoma xenograft bearing models

International Nuclear Information System (INIS)

Wu Hubing; Huang Zuhan; Peng Wuhe; Gao Xiao

2001-01-01

Objective: To conjugate galactose streptavidin (SA-gal) and use it as a clearing agent in pre-targeting radioimmunoimaging (RII) of colon carcinoma xenograft models. Methods: SA-gal was obtained by incubating galactose moiety with streptavidin at a molar ratio of 45 : 1. For imaging in vivo, biotinylated antibody radiolabelled with 131 I was injected into the nude mice bearing the colon carcinoma xenograft via the tail vein. 24 h later, SA-gal were intraperitoneally injected at a ratio of 10-fold (molar) excess to antibody. At 0.5 h and 6 h after SA-gal administration, the animals of different test groups were killed for biodistribution study or imaging. No clearing agent was administrated to the animals of two control groups and they were also killed for biodistribution study or imaging at 24 h or 30 h after injection of 131 I labelled antibody. Results: 1) Galactose moiety was bound to SA at a molar ratio of 20 : 1. 2) In pre-targeting RII, SA-gal undertook the chase effect very fast. At 0.5 h after injection, the blood level of radioactivity decreased very fast and tumor-to-blood (T/B) ratio increased from 0.32 to 1.44. At 6 h after SA-gal administration, T/B ratio reached 5.23, significantly higher than 0.41 of the control group (P 131 I-biotinylated antitumor antibody RII

Mutual regulation of TGF-β1, TβRII and ErbB receptors expression in human thyroid carcinomas

Energy Technology Data Exchange (ETDEWEB)

Mincione, Gabriella, E-mail: g.mincione@unich.it [Department of Experimental and Clinical Sciences, University ‘G. d' Annunzio of Chieti-Pescara, Chieti (Italy); Center of Excellence on Aging, Ce.S.I., ‘G. d' Annunzio’ University Foundation, Chieti (Italy); Tarantelli, Chiara [Department of Experimental and Clinical Sciences, University ‘G. d' Annunzio of Chieti-Pescara, Chieti (Italy); Vianale, Giovina [Department of Experimental and Clinical Sciences, University ‘G. d' Annunzio of Chieti-Pescara, Chieti (Italy); Center of Excellence on Aging, Ce.S.I., ‘G. d' Annunzio’ University Foundation, Chieti (Italy); Di Marcantonio, Maria Carmela [Department of Experimental and Clinical Sciences, University ‘G. d' Annunzio of Chieti-Pescara, Chieti (Italy); Cotellese, Roberto [Department of Experimental and Clinical Sciences, University ‘G. d' Annunzio of Chieti-Pescara, Chieti (Italy); Unit of General and Laparoscopic Surgery, SS Annunziata Hospital, Chieti (Italy); Francomano, Franco [Unit of General and Laparoscopic Surgery, SS Annunziata Hospital, Chieti (Italy); Di Nicola, Marta; Costantini, Erica [Department of Experimental and Clinical Sciences, University ‘G. d' Annunzio of Chieti-Pescara, Chieti (Italy); Cichella, Annadomenica [Unit of General and Laparoscopic Surgery, SS Annunziata Hospital, Chieti (Italy); Muraro, Raffaella [Department of Experimental and Clinical Sciences, University ‘G. d' Annunzio of Chieti-Pescara, Chieti (Italy); Center of Excellence on Aging, Ce.S.I., ‘G. d' Annunzio’ University Foundation, Chieti (Italy)

2014-09-10

The role of EGF and TGF-β1 in thyroid cancer is still not clearly defined. TGF-β1 inhibited the cellular growth and migration of follicular (FTC-133) and papillary (B-CPAP) thyroid carcinoma cell lines. Co-treatments of TGF-β1 and EGF inhibited proliferation in both cell lines, but displayed opposite effect on their migratory capability, leading to inhibition in B-CPAP and promotion in FTC-133 cells, by a MAPK-dependent mechanism. TGF-β1, TβRII and EGFR expressions were evaluated in benign and malignant thyroid tumors. Both positivity (51.7% and 60.0% and 80.0% in FA and PTC and FTC) and overexpression (60.0%, 77.7% and 75.0% in FA, PTC and FTC) of EGFR mRNA correlates with the aggressive tumor behavior. The moderate overexpression of TGF-β1 and TβRII mRNA in PTC tissues (61.5% and 62.5%, respectively), counteracted their high overexpression in FTC tissues (100% and 100%, respectively), while EGFR overexpression was similar in both carcinomas. Papillary carcinomas were positive to E-cadherin expression, while the follicular carcinomas lose E-cadherin staining. Our findings of TGF-β1/TβRII and EGFR overexpressions together with a loss of E-cadherin observed in human follicular thyroid carcinomas, and of increased migration ability MAPK-dependent after EGF/TGF-β1 treatments in the follicular thyroid carcinoma cell line, reinforced the hypothesis of a cross-talk between EGF and TGF-β1 systems in follicular thyroid carcinomas phenotype. - Highlights: • We reinforce the hypothesis of a cross talk between EGF and TGF-β1 in follicular thyroid carcinoma. • Increased migration MAPK-dependent is observed after EGF+TGF-β1 treatment in follicular thyroid carcinoma cells. • EGF and TGF-β1 caused opposite effect on the migratory ability in B-CPAP and in FTC-133 cells. • TGF-β1, TβRII and EGFR are overexpressed in follicular thyroid carcinoma.

Mutual regulation of TGF-β1, TβRII and ErbB receptors expression in human thyroid carcinomas

International Nuclear Information System (INIS)

Mincione, Gabriella; Tarantelli, Chiara; Vianale, Giovina; Di Marcantonio, Maria Carmela; Cotellese, Roberto; Francomano, Franco; Di Nicola, Marta; Costantini, Erica; Cichella, Annadomenica; Muraro, Raffaella

2014-01-01

The role of EGF and TGF-β1 in thyroid cancer is still not clearly defined. TGF-β1 inhibited the cellular growth and migration of follicular (FTC-133) and papillary (B-CPAP) thyroid carcinoma cell lines. Co-treatments of TGF-β1 and EGF inhibited proliferation in both cell lines, but displayed opposite effect on their migratory capability, leading to inhibition in B-CPAP and promotion in FTC-133 cells, by a MAPK-dependent mechanism. TGF-β1, TβRII and EGFR expressions were evaluated in benign and malignant thyroid tumors. Both positivity (51.7% and 60.0% and 80.0% in FA and PTC and FTC) and overexpression (60.0%, 77.7% and 75.0% in FA, PTC and FTC) of EGFR mRNA correlates with the aggressive tumor behavior. The moderate overexpression of TGF-β1 and TβRII mRNA in PTC tissues (61.5% and 62.5%, respectively), counteracted their high overexpression in FTC tissues (100% and 100%, respectively), while EGFR overexpression was similar in both carcinomas. Papillary carcinomas were positive to E-cadherin expression, while the follicular carcinomas lose E-cadherin staining. Our findings of TGF-β1/TβRII and EGFR overexpressions together with a loss of E-cadherin observed in human follicular thyroid carcinomas, and of increased migration ability MAPK-dependent after EGF/TGF-β1 treatments in the follicular thyroid carcinoma cell line, reinforced the hypothesis of a cross-talk between EGF and TGF-β1 systems in follicular thyroid carcinomas phenotype. - Highlights: • We reinforce the hypothesis of a cross talk between EGF and TGF-β1 in follicular thyroid carcinoma. • Increased migration MAPK-dependent is observed after EGF+TGF-β1 treatment in follicular thyroid carcinoma cells. • EGF and TGF-β1 caused opposite effect on the migratory ability in B-CPAP and in FTC-133 cells. • TGF-β1, TβRII and EGFR are overexpressed in follicular thyroid carcinoma

Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2.

Science.gov (United States)

Bendzunas, N George; Dörfler, Sabrina; Autenrieth, Karolin; Bertinetti, Daniela; Machal, Erik M F; Kennedy, Eileen J; Herberg, Friedrich W

2018-03-15

Generation of the second messenger molecule cAMP mediates a variety of cellular responses which are essential for critical cellular processes. In response to elevated cAMP levels, cAMP dependent protein kinase (PKA) phosphorylates serine and threonine residues on a wide variety of target substrates. In order to enhance the precision and directionality of these signaling events, PKA is localized to discrete locations within the cell by A-kinase anchoring proteins (AKAPs). The interaction between PKA and AKAPs is mediated via an amphipathic α-helix derived from AKAPs which binds to a stable hydrophobic groove formed in the dimerization/docking (D/D) domain of PKA-R in an isoform-specific fashion. Although numerous AKAP disruptors have previously been identified that can inhibit either RI- or RII-selective AKAPs, no AKAP disruptors have been identified that have isoform specificity for RIα versus RIβ or RIIα versus RIIβ. As a strategy to identify isoform-specific AKAP inhibitors, a library of chemically stapled protein-protein interaction (PPI) disruptors was developed based on the RII-selective AKAP disruptor, STAD-2. An alanine was substituted at each position in the sequence, and from this library it was possible to delineate the importance of longer aliphatic residues in the formation of a region which complements the hydrophobic cleft formed by the D/D domain. Interestingly, lysine residues that were added to both terminal ends of the peptide sequence to facilitate water solubility appear to contribute to isoform specificity for RIIα over RIIβ while having only weak interaction with RI. This work supports current hypotheses on the mechanisms of AKAP binding and highlights the significance of particular residue positions that aid in distinguishing between the RII isoforms and may provide insight into future design of isoform-selective AKAP disruptors. Copyright © 2018 Elsevier Ltd. All rights reserved.

NECESITATEA FORMĂRII COMPETENŢELOR INOVAŢIONALE LA MANAGERII DIN ÎNVĂŢĂMÂNTUL PREUNIVERSITAR

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Victoria COJOCARU

2016-12-01

Full Text Available Articolul conţine o analiză a entităţilor de bază ale procesului inovaţional în învăţământ, aici înscriindu-se definirea inovaţiei în raport cu inovarea, invenţia, novaţia, reforma etc.; sintetizarea caracteristicilor inovaţiei ca înnoire şi îmbu­nătăţire, ca schimbare în soluţionarea problemelor, orientare a noilor idei spre produse utile, ca factor al dezvoltării învă­ţământului şi instrument al concurenţei.Competenţa este abordată ca o stare care conferă randament, precizie şi siguranţă în rezolvarea sarcinilor; este un model comportamental care exprimă ceea ce poate fi etc. A fost dată o definiţie a competenţei inovaţionale, ca o com­po­nentă a competenţei profesionale, adică manageriale, şi ca un aspect de bază al acestei competenţe.În articol este descrisă Tehnologia inovaţională managerială elaborată în baza schemei tehnologiei inovaţiilor, cri­te­riilor de eficacitate a monitorizării activităţii inovaţionale, tehnologiei Web 2.0, ca mecanism de sprijin.Pornind de la sinteza analitică a domeniilor analizate pe parcurs, în baza elucidării circumstanţelor necesităţii imple­mentării inovaţiilor, a specificului activităţii managerial-inovaţionale, a caracteristicilor personalităţii inovatoare şi prin modelizarea ideilor expuse anterior este argumentată activitatea managerial-inovaţională a managerilor, care este o activitate a subiectului de creare, elaborare, însuşire a inovaţiilor în conţinutul funcţiilor manageriale, utilizarea metode­lor, structurii organizaţionale, implementării în practică a obiectivelor propuse în scop de eficientizare a monitori­zării şi dezvoltării instituţiei.Cuvinte-cheie: inovare, inovaţie, activitate managerial-inovaţională, tehnologie inovaţională managerială şi com­petenţă inovaţională. MANAGERS NEED INNOVATIVE SKILLS TRAINING IN SECONDARY EDUCATIONThe article contains an analysis of the basic

Nüüd oleme meie need, kes jätavad siia maale oma jälje / Ivari Padar

Index Scriptorium Estoniae

Padar, Ivari, 1965-

2008-01-01

Ilmunud ka: Vali Uudised 22. veebr., lk. 2, Harju Ekspress 22. veebr., lk. 6, Hiiu Leht 22. veebr., lk. 2, Kuulutaja 22. veebr. lk. 4, Järva Teataja 23. veebr., lk. 2, Vooremaa 23. veebr., lk. 2, Võrumaa Teataja 23. veebr., lk. 2, Meie Maa 23. veebr., lk. 2, Narvskaja Gazeta 23. veebr. lk. 5. Rahandusminister Ivari Padari tervitus vabariigi 90. aastapäeva puhul

Eesti toit jääb püsima vaid meie kaasabil / Ester Tuiksoo

Index Scriptorium Estoniae

Tuiksoo, Ester, 1965-

2005-01-01

Vt. ka Delovõje Vedomosti 17. aug. lk. 6, Virumaa Teataja 18. aug, lk. 7, Nädaline : Talu Leht 18. aug., lk. 10, Lääne Elu 18. aug., lk. 2, Lõunaleht 18. aug. lk. 2, Põhjarannik, 19. aug, lk. 2 Severnoje Poberezhje 19. aug., lk. 2, Vali Uudised 19. aug., lk. 2, Sakala 19. aug., lk. 2, Harjumaa 19. aug. lk. 2, Valgamaalane 23. aug., lk. 2, Hiiu Leht 23. aug., lk. 2, Koit 23. aug. lk. 6, Meie Maa 25. aug. lk. 5, Narvskaja Nedelja 5. nov. lk. 5. Põllumajandusminister põhjendab arengukava "Eesti toit" vajalikkust ja selgitab arengukava eesmärke

Cadru pentru crearea unei culturi a învăţării şi a partajării cunoaşterii în biblioteci şi servicii de informare

Directory of Open Access Journals (Sweden)

Octavia-Luciana Madge

2012-01-01

Full Text Available Performanţa unei organizaţii, inclusiv a unei structuri infodocumentare de tipul bibliotecă sau serviciu de informare, depinde în mare măsură de cultura sa organizaţională, de valorile pe care aceasta le promovează. Competiţia care se înregistrează pe piaţa transferului de informaţii a făcut ca bibliotecile şi serviciile de informare să se orienteze spre procese manageriale care au în vedere cele mai importante resurse la momentul actual – resursele de cunoaştere. Un astfel de proces este managementul cunoaşterii, iar un rol esenţial în implementarea acestuia într-o instituţie îl are cultura organizaţională. O cultură care susţine învăţarea şi partajarea cunoaşterii susţine organizaţiile într-un astfel de demers şi, de asemenea, le ajută să obţină performanţă şi să se bucure de succes în mediul în care activează. Articolul prezintă elementele unei cadru pentru crearea unei culturi a învăţării şi a partajării cunoaşterii în structurile infodocumentare. Aceste elemente au fost identificate în urma unei cercetări vizând managementul cunoaşterii în bibliotecile universitare româneşti care a avut ca rezultat şi dezvoltarea unui model pentru implementarea acestui proces în structurile infodocumentare.

The R-Process Alliance: 2MASS J09544277+5246414, the Most Actinide-enhanced R-II Star Known

Science.gov (United States)

Holmbeck, Erika M.; Beers, Timothy C.; Roederer, Ian U.; Placco, Vinicius M.; Hansen, Terese T.; Sakari, Charli M.; Sneden, Christopher; Liu, Chao; Lee, Young Sun; Cowan, John J.; Frebel, Anna

2018-06-01

We report the discovery of a new actinide-boost star, 2MASS J09544277+5246414, originally identified as a very bright (V = 10.1), extremely metal-poor ([Fe/H] = ‑2.99) K giant in the LAMOST survey, and found to be highly r-process-enhanced (r-II; [Eu/Fe] = +1.28]), during the snapshot phase of the R-Process Alliance (RPA). Based on a high signal-to-noise ratio (S/N), high-resolution spectrum obtained with the Harlan J. Smith 2.7 m telescope, this star is the first confirmed actinide-boost star found by RPA efforts. With an enhancement of [Th/Eu] = +0.37, 2MASS J09544277+5246414 is also the most actinide-enhanced r-II star yet discovered, and only the sixth metal-poor star with a measured uranium abundance ([U/Fe] = +1.40). Using the Th/U chronometer, we estimate an age of 13.0 ± 4.7 Gyr for this star. The unambiguous actinide-boost signature of this extremely metal-poor star, combined with additional r-process-enhanced and actinide-boost stars identified by the RPA, will provide strong constraints on the nature and origin of the r-process at early times.

Construction scheduled delay risk assessment by using combined AHP-RII methodology for an international NPP project

Energy Technology Data Exchange (ETDEWEB)

Hossen, Mufazal Muhammed; Kang, Sun Koo; Kim, Jong Hyun [KEPCO International Nuclear Graduate School (KINGS), Ulsan (Korea, Republic of)

2015-04-15

In this study, Nuclear Power Plant (NPP) construction schedule delay risk assessment methodology is developed and the construction delay risk is assessed for turnkey international NPP projects. Three levels of delay factors were selected through literature review and discussions with nuclear industry experts. A questionnaire survey was conducted on the basis of an analytic hierarchy process (AHP) and Relative Importance Index (RII) methods and the schedule delay risk is assessed qualitatively and quantitatively by severity and frequency of occurrence of delay factors. This study assigns four main delay factors to the first level: main contractor, utility, regulatory authority, and financial and country factor. The second and the third levels are designed with 12 sub-factors and 32 sub-sub-factors, respectively. This study finds the top five most important sub-sub-factors, which are as follows: policy changes, political instability and public intervention; uncompromising regulatory criteria and licensing documents conflicting with existing regulations; robust design document review procedures; redesign due to errors in design and design changes; and worldwide shortage of qualified and experienced nuclear specific equipment manufacturers. The proposed combined AHP-RII methodology is capable of assessing delay risk effectively and efficiently. Decision makers can apply risk informed decision making to avoid unexpected construction delays of NPPs.

Construction scheduled delay risk assessment by using combined AHP-RII methodology for an international NPP project

International Nuclear Information System (INIS)

Hossen, Mufazal Muhammed; Kang, Sun Koo; Kim, Jong Hyun

2015-01-01

In this study, Nuclear Power Plant (NPP) construction schedule delay risk assessment methodology is developed and the construction delay risk is assessed for turnkey international NPP projects. Three levels of delay factors were selected through literature review and discussions with nuclear industry experts. A questionnaire survey was conducted on the basis of an analytic hierarchy process (AHP) and Relative Importance Index (RII) methods and the schedule delay risk is assessed qualitatively and quantitatively by severity and frequency of occurrence of delay factors. This study assigns four main delay factors to the first level: main contractor, utility, regulatory authority, and financial and country factor. The second and the third levels are designed with 12 sub-factors and 32 sub-sub-factors, respectively. This study finds the top five most important sub-sub-factors, which are as follows: policy changes, political instability and public intervention; uncompromising regulatory criteria and licensing documents conflicting with existing regulations; robust design document review procedures; redesign due to errors in design and design changes; and worldwide shortage of qualified and experienced nuclear specific equipment manufacturers. The proposed combined AHP-RII methodology is capable of assessing delay risk effectively and efficiently. Decision makers can apply risk informed decision making to avoid unexpected construction delays of NPPs

FACTORI ŞI PARTICULARITĂŢI PSIHOSOCIALE ALE ADAPTĂRII COPIILOR CU CERINŢE EDUCAŢIONALE SPECIALE

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Segiu TOMA

2016-12-01

Full Text Available În articol este abordată problema privind factorii şi particularităţile psihosociale ale adaptării copiilor cu CES în instituţii de învăţământ. Accentul se pune pe analiza factorilor psihologici, sociali, fiind evidenţiată „inteligenţa” ca un mecanism reglator. Alt factor ţine de motivaţia extrinsecă şi cea intrinsecă. Pe larg se analizează nivelul de aspiraţie, afectivitatea, capacitatea de autoreglare, imaginea de sine ca factori determinanţi ai adaptării copiilor cu CES în institu­ţiile de învăţământ.PSYCHOSOCIAL FACTORS AND PECULIARITIES OF ADAPTATION OF CHILDREN WITH SPECIAL EDUCATIONAL REQUIREMENTSThe article does not give address psychosocial factors and peculiarities of adaptation of children with SEN in schools. The focus is on analyzing the psychological, social factors, highlighting the "intelligence" as a regulatory mechanism. Another factor related to the intrinsic and extrinsic motivation extensively analyzed the level of aspiration, affect the ability of self-regulation, self-image, as drivers of adaptation of SEN children in educational institutions.          

Total and partial sleep deprivation: Effects on plasma TNF-αRI, TNF-αRII, and IL-6, and reversal by caffeine operating through adenosine A2 receptor

Science.gov (United States)

Shearer, William T.; Reuben, James M.; Lee, Bang-Ning; Mullington, Janet; Price, Nicholas; Dinges, David F.

2000-01-01

Plasma levels of IL-6 and TNF-α are elevated in individuals who are deprived of sleep. TNF-α regulates expression of its soluble receptors, sTNF-αRI and sTNF-αRII. Sleep deprivation (SD) also increases extracellular adenosine that induces sedation and sleep. An antagonist of adenosine, caffeine, raises exogenous adenosine levels, stimulates the expression of IL-6 and inhibits the release of TNF-α. Our objective was to determine the effect of total SD (TSD) or partial SD (PSD) on the levels of these sleep regulatory molecules in volunteers who experienced SD with or without the consumption of caffeine. Plasma levels of IL-6, sTNF-αRI and sTNF-αRII were assayed by ELISA in samples collected at 90-min intervals from each subject over an 88-hour period. The results were analyzed by the repeated measures ANOVA. Whereas only TSD significantly increased sTNF-αRI over time, caffeine suppressed both sTNF-α receptors in TSD and PSD subjects. The selective increase in the expression of sTNF-αRI and not sTNF-αRII in subjects experiencing TSD with caffeine compared with others experiencing PSD with caffeine has not been previously reported. Moreover, caffeine significantly increased IL-6 in TSD subjects compared with those who did not receive caffeine. However, subjects who were permitted intermittent naps (PSD) ablated the effects of caffeine and reduced their level of IL-6 to that of the TSD group. These data further lend support to the hypothesis that the sTNF-αRI and not the sTNF-αRII plays a significant role in sleep regulation by TNF-α. .

Relative importance index (RII) in ranking of procrastination factors among university students

Science.gov (United States)

Aziz, Nazrina; Zain, Zakiyah; Mafuzi, Raja Muhammad Zahid Raja; Mustapa, Aini Mastura; Najib, Nur Hasibah Mohd; Lah, Nik Fatihah Nik

2016-08-01

Procrastination is the action of delaying or postponing something such as making a decision or starting or completing some tasks or activities. According to previous studies, students who have a strong tendency to procrastinate get low scores in their tests, resulting in poorer academic performance compared to those who do not procrastinate. This study aims to identify the procrastination factors in completing assignments among three groups of undergraduate students. The relative importance of procrastination factors was quantified by the relative importance index (RII) method prior to ranking. A multistage sampling technique was used in selecting the sample. The findings revealed that `too many works in one time' is one of the top three factors contributing to procrastination in all groups.

Tallinna uus raekoda : väljavõtted žürii raportist = Tallinn new City Hall : excerpts from the jury raport

Index Scriptorium Estoniae

2009-01-01

Tallinna Linnavalitsuse uue administratiivhoone rahvusvahelisest ideekonkursist, premeeritud töödest, žürii koosseis. 1. preemia sai töö "The Public Village", autoriteks Bjarke Ingels ja Jakob Lange (Bjarke Ingels Group ApS) Taanist, 2. preemia töö "Rahva Hääl" (Alver Arhitektid) ja 3. preemia töö "Koda" (Kolm Pluss Üks)

The Critical Pedagogical Potential of Using Jacob A. Riis' Works about the Immigrant Poor in "Gilded Age" New York

Science.gov (United States)

Templer, Bill

2017-01-01

The article seeks to contribute to working-class and social justice pedagogy by developing concrete angles on teaching/exploring some of the (a) short fiction, (b) journalistic-photographic work and (c) sociography of poverty by the Danish-born US immigrant, muckraker (http://goo.gl/6WeGtM) and social reformer Jacob A. Riis (1849-1914,…

Pictorial Representation of Illness and Self Measure Revised II (PRISM-RII) - a novel method to assess perceived burden of illness in diabetes patients

NARCIS (Netherlands)

Klis, S.; Vingerhoets, A.J.M.M.; de, W.M.; Zandbelt, N.; Snoek, F.J.

2008-01-01

Background: The Pictorial Representation of Illness and Self Measure (PRISM) has been introduced as a visual measure of suffering. We explored the validity of a revised version, the PRISM-RII, in diabetes patients as part of the annual review. Methods: Participants were 308 adult outpatients with

Safety and Immunogenicity of EBA-175 RII-NG Malaria Vaccine Administered Intramuscularly in Semi-Immune Adults: A Phase 1, Double-Blinded Placebo Controlled Dosage Escalation Study.

Science.gov (United States)

Koram, Kwadwo A; Adu, Bright; Ocran, Josephine; Karikari, Yaa S; Adu-Amankwah, Susan; Ntiri, Michael; Abuaku, Benjamin; Dodoo, Daniel; Gyan, Ben; Kronmann, Karl C; Nkrumah, Francis

2016-01-01

The erythrocyte binding antigen region II (EBA-175 RII) is a Plasmodium falciparum ligand that mediates erythrocyte invasion and is considered an important malaria vaccine candidate. A phase Ia trial in malaria naïve adults living in the United States found the recombinant non-glycosylated vaccine antigen, EBA-175 RII-NG adjuvanted with aluminium phosphate to be safe, immunogenic and capable of inducing biologically active antibodies that can inhibit parasite growth in vitro. The aim of the current study was to assess the safety and immunogenicity of this vaccine in malaria exposed semi-immune healthy adults living in a malaria endemic country, Ghana. In this double-blinded, placebo controlled, dose escalation phase I trial, eighteen subjects per group received ascending dose concentrations (5 μg, 20 μg or 80 μg) of the vaccine intramuscularly at 0, 1 and 6 months, while 6 subjects received placebo (normal saline). The primary end point was the number of subjects experiencing Grade 3 systemic or local adverse events within 14 days post-vaccination. Serious adverse events were assessed throughout the study period. Blood samples for immunological analyses were collected at days 0, 14, 28, 42, 180 and 194. A total of 52 subjects received three doses of the vaccine in the respective groups. No serious adverse events were reported. The majority of all adverse events reported were mild to moderate in severity, with local pain and tenderness being the most common. All adverse events, irrespective of severity, resolved without any sequelae. Subjects who received any of the EBA-175 RII-NG doses had high immunoglobulin G levels which moderately inhibited P. falciparum growth in vitro, compared to those in the placebo group. In conclusion, the EBA-175 RII-NG vaccine was safe, well tolerated and immunogenic in malaria semi-immune Ghanaian adults. Its further development is recommended. ClinicalTrials.gov. Identifier: NCT01026246.

Safety and Immunogenicity of EBA-175 RII-NG Malaria Vaccine Administered Intramuscularly in Semi-Immune Adults: A Phase 1, Double-Blinded Placebo Controlled Dosage Escalation Study.

Directory of Open Access Journals (Sweden)

Kwadwo A Koram

Full Text Available The erythrocyte binding antigen region II (EBA-175 RII is a Plasmodium falciparum ligand that mediates erythrocyte invasion and is considered an important malaria vaccine candidate. A phase Ia trial in malaria naïve adults living in the United States found the recombinant non-glycosylated vaccine antigen, EBA-175 RII-NG adjuvanted with aluminium phosphate to be safe, immunogenic and capable of inducing biologically active antibodies that can inhibit parasite growth in vitro. The aim of the current study was to assess the safety and immunogenicity of this vaccine in malaria exposed semi-immune healthy adults living in a malaria endemic country, Ghana. In this double-blinded, placebo controlled, dose escalation phase I trial, eighteen subjects per group received ascending dose concentrations (5 μg, 20 μg or 80 μg of the vaccine intramuscularly at 0, 1 and 6 months, while 6 subjects received placebo (normal saline. The primary end point was the number of subjects experiencing Grade 3 systemic or local adverse events within 14 days post-vaccination. Serious adverse events were assessed throughout the study period. Blood samples for immunological analyses were collected at days 0, 14, 28, 42, 180 and 194. A total of 52 subjects received three doses of the vaccine in the respective groups. No serious adverse events were reported. The majority of all adverse events reported were mild to moderate in severity, with local pain and tenderness being the most common. All adverse events, irrespective of severity, resolved without any sequelae. Subjects who received any of the EBA-175 RII-NG doses had high immunoglobulin G levels which moderately inhibited P. falciparum growth in vitro, compared to those in the placebo group. In conclusion, the EBA-175 RII-NG vaccine was safe, well tolerated and immunogenic in malaria semi-immune Ghanaian adults. Its further development is recommended.ClinicalTrials.gov. Identifier: NCT01026246.

ASPECTE DE ARGUMENTARE A RESPONSABILIZĂRII PENTRU CANTITATEA ŞI CALITATEA APEI

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Maria SANDU

2016-02-01

Full Text Available Cantitatea apei pe planetă este estimată la 1,338 mld km3, din care doar 2,57% este apă dulce. Însă, din apele dulci lichide doar 3% se estimează ca fiind prelevabile pentru consumul uman, cantitate foarte mică, ţinându-se cont de creşte­rea continuă a consumului de apă în ultimele decenii. De exemplu, consumul global de apa s-a triplat din 1950 până în 1990, iar în perioada a. 1990-1995 acesta a crescut de şase ori. Problemele ce vizează cantitatea şi calitatea apei sunt legate de distribuirea ei inegală pe glob, reducerea cantităţii de apă potabilă, poluarea în creştere cu substanţe organice, compuşi ai azotului, metale etc. Rezultatele scontate pot fi atinse doar prin responsabilizarea tuturor cetăţenilor Republicii Moldova. Acest studiu vine să argumenteze importanţa examinării calităţii apei, stabilirii unor cauze de poluare, să implice populaţia în activităţi de prevenire şi reducere a poluării. ASPECTS OF THE ARGUMENTATION OF ACCOUNTABILITY FOR THE QUANTITY AND QUALITY OF WATERThe quantity of water on the planet is estimated at 1,338 million km3 of which only 2,57% is freshwater. But from liquid freshwater, only 3% is expected to be taken for human consumption, which, in fact, is in growing. For example, global water consumption has tripled from 1950 to 1990 and in the period of 1990-1995 years it increased six times. Problems related to water quantity and quality are related to its uneven distribution around the globe, by reducing the amount of potable water, increasing pollution with organic substances, nitrogen compounds, heavy metals, etc. Water quality can be improved only by empowering all citizens in the Republic of Moldova, by motivating them to get involved in all activities to protect waters in the territory. This study comes to argue the importance of examining water quality, listing the causes of pollution, involvement in all activities to prevent and reduce pollution. 

Principiile organizării administrației publice locale consacrate de Constituția României și de legea nr. 69/1991

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Rodica PETRESCU

1999-01-01

Full Text Available Constituţia României în art. 119 prevede că administraţia publică din unităţile administrativ-teritoriale se întemeiază pe principiul autonomiei locale şi pe cel al descentralizării serviciilor publice.

"Scripta manent" on meie regioonis ainulaadne üritus / Sirje Kriisa, Lennart Mänd, Rene Haljasmäe...[jt.] ; üles kirjutanud Reet Varblane

Index Scriptorium Estoniae

2005-01-01

Kuni 2. X Eesti Tarbekunsti- ja Disainimuuseumis avatud rahvusvahelisest köitekunstinäitusest "Scripta manent III. Maailma parim asi". Köitekunstist kõnelesid näituse korralduskomitee liikmed. Žürii koosseis. Kuldraamatud pälvisid Külli Grünbach-Sein, Kaire Olt ja Jaana Päeva. Näituse korralduskomitees ka Tulvi-Hanneli Turo ja Rene Haljasmäe TLÜARist

Approximate estimation method of the degree of lanthanide tetr[ effect and application to the tetr[ effects in lanthanide ionic r[ii

International Nuclear Information System (INIS)

Minami, M.

1998-01-01

Fitting of qu[ratic curves to four defined subgroups of lanthanides shows that the tetr[ effects in Ln 3+ ionic r[ii with coordination number (CN) 6 are larger than those with CN 8. The features for the first tetr[ are peculiar compared with other three subgroups, with both CN. The observed facts can be explained in terms of configuration of 4f electron clouds and their interaction with ligands. (orig.)

VICTIMA DETERMINĂRII LA SINUCIDERE (ART.150 CP RM: EXPLICAŢII PSIHOLOGO-PSIHIATRICE ÎN LUAREA DECIZIEI DEFINITIVE DE SUICID

Directory of Open Access Journals (Sweden)

Lilia GÎRLA

2016-11-01

Full Text Available Scopul acestui studiu constă în: cercetarea ştiinţifică a portretului psihologic al victimei determinării la sinucidere (art.150 CP RM prin oferirea explicaţiilor psihologo-psihiatrice, precum şi medico-legale relevante momentului for­mă­rii şi luării deciziei suicidare la victimă. În special, mesajul este dedicat aspectelor contradictorii de delimitare a suicidu­lui voluntar, a determinării la sinucidere de omorul intenţionat al victimei săvârşit prin forţa lui fizică. În acest sens, autorul a aderat la opiniile doctrinare care promovează ideea că factorii interni (cum ar fi patologia psihiatrică la victimă este una determinativă la săvârşirea actului suicidar „voluntar”, iar factorii sociali (externi sunt caracteristici determinării la sinucidere în sensul art.150 CP RM, cu condiţia că aceşti factori sunt „necesari” şi „suficienţi” (condiţie sine qua non pentru luarea deciziei suicidare. În cazul în care decizia de a se sinucide nu se află în legătură de cauzalitate cu com­porta­mentul făptuitorului, fiind o reacţie imprevizibilă, irelevantă şi excesivă, componenţa infracţională prevăzută la art.150 CP RM va lipsi. Problema sinuciderii în cadrul eutanasiei nu constituie obiectul de cercetare al acestui articol.Pentru a obţine concluzii relevante şi superioare celor precedente în doctrină, se va purcede la o analiză multiaspec­tuală a conceptului de suicid, la o abordare pluridisciplinară (drept penal, psihologie, psihiatrie, medicina legală, crimi­no­logie, sociologie a acestui fenomen, precum şi vor fi utilizate anumite concluzii relevante din practica CtEDO, practica judiciară a Republicii Moldova şi cea a României.victim of the inducement to suicide (art.150 Cc rm: psychological and psychiatric explanations concerning the final decision-making in the suicideThe basic purpose of present study consists in scientific research of the psychological portrait of

Ebaprofessionaalne kriisijuhtimine võib halvata koondatavate ja töölejäänute töövõime pikaks ajaks / Maire Riis ; intervjueerinud Tiina Saar

Index Scriptorium Estoniae

Riis, Maire

2009-01-01

Traumateraapia ja koolituskeskuse juht ning koolitaja Maire Riis vastab küsimustele, mis puudutavad koondamise või töö kaotamise mõju inimesele, ettevõtte juhtide võimalustest koondamisega seotud trauma leevendamiseks, tööle allesjäänutele tähelepanu pööramist ning koondamisjärgset kriisi ja selle ületamist

Genetic progression in microsatellite instability high (MSI-H) colon cancers correlates with clinico-pathological parameters: A study of the TGRbetaRII, BAX, hMSH3, hMSH6, IGFIIR and BLM genes.

Science.gov (United States)

Calin, G A; Gafà, R; Tibiletti, M G; Herlea, V; Becheanu, G; Cavazzini, L; Barbanti-Brodano, G; Nenci, I; Negrini, M; Lanza, G

2000-05-20

Colon carcinomas with microsatellite mutator phenotype exhibit specific genetic and clinico-pathological features. This report describes the analysis of 63 "microsatellite instability-high" (MSI-H) tumors for the presence of mutations in microsatellites located in the coding regions (CDRs) of 6 genes: TGFbetaRII, BAX, hMSH3, hMSH6, IGFIIR, and BLM. The following frequencies of mutations were detected: TGFbetaRII (70%), BAX (54%), hMSH3 (36.5%), IGFIIR (22%), hMSH6 (17.5%), and BLM (16%). The overall picture revealed combinations of mutations suggestive of a progressive order of accumulation, with mutations of TGFbetaRII and BAX first, followed by frameshifts in hMSH3, hMSH6, IGFIIR, and BLM. Correlations with 12 clinico-pathological parameters revealed that tumors with frameshifts in 1 or 2 CDRs were significantly better differentiated than tumors with frameshifts in more than 2 CDRs. We also found that mutations in the hMSH3 gene were significantly associated with decreased wall invasiveness and aneuploidy, and frameshifts in the BLM gene were significantly associated with the mucinous histotype. A trend toward an association between hMSH3 and IGFIIR with the medullary and conventional adenocarcinoma histotypes, respectively, was seen. Our results strengthen the concept that mutations in target genes have a role in the tumorigenic process of MSI-H tumors, and indicate that frameshifts in microsatellites located in CDRs occur in a limited number of combinations that could determine distinct clinico-pathological traits. Copyright 2000 Wiley-Liss, Inc.

Aasta betoonehitise žürii kommentaarid võistlustöödele ja võitjaile / Eva Kiisler, Maritta Koivisto, Angel Andla...[jt.] ; intervjueerinud Mari Sarv ; kommenteerinud Mart Riikoja

Index Scriptorium Estoniae

2009-01-01

Konkursile "Aasta Betoonehitis 2008" annavad hinnangu Eva Kiisler (ajakirja "Ehitaja" peatoimetaja), Maritta Koivisto (Soome ajakirja "Betoni" peatoimetaja"), Angel Andla (Eesti Ehitusettevõtjate Liit), Heiki Meos (Eesti Ehitusinseneride Liit), Siim Sultson ("Äripäeva" ehitusvaldkonna toimetaja), Toomas Laur (Eesti Betooniühing), Ike Volkov (Eesti Arhitektide Liidu esimees), Mauno Inkinen (Eesti Projektbüroode Liit), Enno Rebane (Eesti Ehitusmaterjalide Tootjate Liidu tegevdirektor). Mart Riikoja žürii tööst

MODELUL FORMĂRII COMPETENȚELOR STUDENȚILOR PRIN SITUAȚII DIDACTICE

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Nicoleta BLEANDURĂ

2017-07-01

Full Text Available Scopul principal al instruirii universitare bazate pe abordarea prin competenţe constă în formarea la student a competențelor necesare pentru a trata cu succes situațiile din viața profesională. Situația este astfel crucială în procesul de formare a competențelor. În articol este prezentat şi descris modelul procesului de formare a competențelor viitorilor profesori de informatică prin situații didactice. Sunt descrise teoriile care au stat la baza dezvoltării modelului. Este prezentată atât structura logică, cât şi temporală a procesului. În final se face o analiză a factorilor ce apar în procesul de utilizare în practică a modelului elaborat.THE MODEL OF THE STUDENTS’ COMPETENCE DEVELOPMENT THROUGH DIDACTICAL SITUATIONSThe main purpose of the university training, set up on competence based approach is to form competent students who can successfully solve professional life situations. The situation is crucial in this regard. The article presents the model of the competence development process through didactical situations of the future teachers of informatics. The theoretical foundations that directed the development of the model, as well as the the logical and temporal structure of the process are described. Finally, an analysis of issues appearing during the practical use of the model is made.

Isolated single coronary artery (RII-B type presenting as an inferior wall myocardial infarction: A rare clinical entity

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Ankur C. Thummar

2014-09-01

Full Text Available Isolated single coronary artery without other congenital cardiac anomalies is very rare among the different variations of anomalous coronary patterns. The prognosis in patients with single coronary varies according to the anatomic distribution and associated coronary atherosclerosis. If the left main coronary artery travels between the aorta and pulmonary arteries, it may be a cause of sudden cardiac death. We present multimodality images of a single coronary artery, in which the whole coronary system originated by a single trunk from the right sinus of Valsalva with inter-arterial course of left main coronary artery. This rare type of single coronary artery was classified as RII-B type according to Lipton's scheme of classification. A significant flow-limiting lesions were found in the right coronary artery that was successfully treated with percutaneous coronary intervention.

PARTICULARITĂŢILE PROBLEMELOR CARE URMEAZĂ A FI SOLUŢIONATE ÎN CADRUL INVESTIGĂRII CRIMINALISTICE A INFRACŢIUNILOR INFORMATICE

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Svetlana PURICI

2015-11-01

Full Text Available Scopul principal al acestui studiu nu este de a releva regulile generale ale admisibilităţii probelor (pentru că pornim de la supoziţia că acesta este un fapt cunoscut de cititori, ci reprezintă un studiu cu privire la problemele specifice ale „investigării criminalităţii cibernetice” în procesul penal şi criminalistică.PARTICULARITIES OF THE PROBLEMS TO BE SOLVED IN FORENSIC INVESTIGATION OF CYBERCRIMEThe main task of this study is not to show the general rules of admissibility - because we are starting from the supposition that it's a known fact by the readers - but it will present a study about specific rules of the “cybercrime investigations” in the criminal procedure law and forensics.

ESL aastapreemia 2007 žürii koosoleku protokoll : 7. aprill 2008 = Estonian Society of Interior Architects annual award 2007 : official minutes of the meeting of the jury : 7 April 2008

Index Scriptorium Estoniae

2008-01-01

2007. a. ühiskondliku interjööri preemia: Tea Tammelaan, Malle Jürgenson, Krista Lepland (Lotte lasteaed), ajaloolise interjööri preemia: Külli Salum, Riina Harik (hotell Telegraaf), büroointerjööri preemia: Urmo Vaikla, Tüüne-Kristin Vaikla (Sakubü büroo), publitsistika preemia: Karen Jagodin, Tiit Jürna (näitusekataloog "Tamm ja Asi", eripreemia: Margus Mänd (klubi Underground). Žürii koosseis

ESL aastapreemia 2006 žürii koosoleku protokoll : 4. aprill 2007 = ESL annual prize 2006 official minutes of the meeting of the jury : April 4th 2007

Index Scriptorium Estoniae

2007-01-01

2006. a. ühiskondliku interjööri preemia Hannelore Pihlakule ja Kristi Lentsile Viimsi koolimaja interjööride eest, ajaloolise interjööri preemia Lembit Andres Torgile firma Koger & Partnerid kontori interjööride eest Fahle majas, näitusekujunduse preemia Mari Kurismaale ja Mari Kaljustele Kumu Kunstimuuseumis eksponeeritud Felicie Ropsi loomingu näituse "Eros ja Surm" kujunduse ja graafilise kujunduse eest, büroo interjööri preemia Taavi Aunrele Velvet Creative Alliance bürooruumide interjööride eest, esemepreemia Tiina Mangile diivanikomplekti Black eest. Žürii koosseis lk. 8

Identification of a highly conserved domain in the EcoRII methyltransferase which can be photolabeled with S-adenosyl-L-[methyl-3H]methionine. Evidence for UV-induced transmethylation of cysteine 186

International Nuclear Information System (INIS)

Som, S.; Friedman, S.

1991-01-01

DNA methyltransferases can be photolabeled with S-adenosyl-L-methionine (AdoMet). Specific incorporation of radioactivity has been demonstrated after photolabeling with either [methyl-3H]AdoMet or [35S]AdoMet. The labeling is believed to occur at the AdoMet binding site. With the purpose of localizing the site responsible for [methyl-3H]AdoMet photolabeling, we cleaved the labeled EcoRII methyltransferase by chemical and enzymatic reactions and isolated the radiolabeled peptides by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and high pressure liquid chromatography. The labeled peptides were identified by amino-terminal sequencing. A common region was localized which accounted for 65-70% of the total label. This region includes a highly conserved core sequence present in all DNA (cytosine 5)-methyltransferases. One such fragment was digested further with chymotrypsin, and amino acid analysis of the resulting 3H-labeled peptide was consistent with the sequence Ala-Gly-Phe-Pro-(Cys)-Gln-Pro-Phe-Ser-Leu. However, the cysteine residue was not recovered as carboxymethylcysteine. The Pro-Cys bond was found to be protected from cleavage at cysteine residues after cyanylation. These results suggest that the cysteine residue is modified by the labeling reaction. The chymotryptic fragment was hydrolyzed enzymatically to single amino acids, and the labeled amino acid was identified as S-methylcysteine by thin layer chromatography. These results indicate that the cysteine residue is located at or close to the AdoMet binding site of EcoRII methyltransferase

MODELUL PROIECTĂRII TRASEELOR INDIVIDUALE DE ÎNVĂŢARE ALE STUDENŢILOR ÎN MEDII DIGITALE

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Ghenadie CABAC

2017-03-01

Full Text Available Abordarea individuală a instruirii, deşi permite a adapta procesul de formare la particularităţile individuale ale stu­denţilor, rămâne o abordare centrată pe profesor, iar calea după care studenţii parcurg o disciplină universitară (traseul de învăţare este una şi aceeaşi. Pentru a implica plenar studenţii în activitatea de învăţare, didactica modernă propune individualizarea instruirii prin construirea de către student a propriului program de formare. În lucrare este descris modelul proiectării traseelor individuale de învăţare ca activitate comună a cadrului didactic şi a studentului.MODEL DESIGN OF INDIVIDUAL LEARNING PATHWAY STUDENTS IN DIGITAL MEDIAAlthough individual approach to training allows to adapt the teaching process to students’ individual character­ristics, it remains a teacher-centered approach, but the path students follow while acquiring an academic discipline (learning path is the same. To fully engage students in learning activities, modern didactics individualizes instruct­tion by building the student's own training programme. The paper describes the model of designing individual learning paths as a joint activity between the teacher and the student.

BOOK REVIEW - Adrian Liviu Ivan, Teorii și practice ale integrării europene [Theories and Practices of European Integration

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Adrian Daniel STAN

2016-06-01

Full Text Available Teorii și practice ale integrării europene [Theories and Practices of European Integration] is a genuine contribution to understanding how the European Union’s particular character has been adjusted in more than half of century of institutional growth and development. Professor Ivan`s key argument for this book is that the European Union has been shaped as a functional project taking into consideration the diverse heritage and traditions of its Member States. The opening chapter of this book focuses on the particularities of international relations discipline after the Second World War in order to introduce the theme of European Integration Process. This chapter must be analysed in a series of contributions dedicated to the European Integration process and to the theories that made this integration possible because professor Ivan has previously published books such as: Statele Unite ale Europei [The United States of Europe], Sub zodia Statelor Unite ale Europei [Under the Sign of the United States of Europe], in which he debates the origins of the European construction and brings forward arguments to support the importance of each theoretical and functional pillar of this “Common European Project”.

Cultura informaţiei – o nouă abordare în sprijinul dezvoltării abilităţilor didactice

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Agnes Erich

2012-01-01

Full Text Available Cultura informaţională reprezintă un factor determinant în dezvoltarea societăţii informaţionale deoarece o societate bazată pe instruirea pe parcursul întregii vieţi este de neconceput fără o cultură informaţională adecvată. În acest sens, aceasta devine condiţia primordială a profesionalismului şi succesului viitorului specialist din orice domeniu. Iată de ce, concomitent cu pregătirea profesională, studentul trebuie să dobândească deprinderi şi proprie experienţă în informarea ştiinţifică. Competenţele informaţionale constituie factorul cheie în educaţia pe parcursul întregii vieţi, ea fiind primul pas pec alea realizării scopurilor educaţionale. În lucrarea de faţă ne propunem să scoatem în evidenţă rolul primordial pe care îl are cultura informaţiei în educaţia oricărui individ din societate dar şi ajutorul pe care aceasta îl oferă cadrelor didactice în ceea ce priveşte dezvoltarea abilităţilor didactice.

Characterization of the regulatory subunit from brain cyclic AMP-dependent protein kinase II

International Nuclear Information System (INIS)

Stein, J.C.

1985-01-01

Tryptic peptides derived from the regulatory subunits of brain and heart cAMP-dependent protein kinase II were mapped by reverse phase HPLC. At 280 nm, 15 unique peptides were found only in the heart RII digest, while 5 other peptides were obtained only from brain RII. At 210 nm, 13 brain-RII specific and 15 heart-RII specific tryptic peptides were identified and resolved. Two-dimensional mapping analyses revealed that several 37 P-labeled tryptic fragments derived from the autophosphorylation and the photoaffinity labeled cAMP-binding sites of brain RII were separate and distinct from the 32 P-peptides isolated from similarly treated heart RII. The tryptic phosphopeptide containing the autophosphorylation site in brain RII was purified. The sequence and phosphorylation site is: Arg-Ala-Ser(P)-Val-Cys-Ala-Glu-Ala-Tyr-Asn-Pro-Asp-Glu-Glu-Glu-Asp-Asp-Ala-Glu. Astrocytes and neurons exhibit high levels of the brain RII enzyme, while oligodendrocytes contain the heart RII enzyme. Monoclonal antibodies to bovine cerebral cortex RII were made and characterized. The antibodies elucidated a subtle difference between membrane-associated and cytosolic RII from cerebral cortex

Aegade varjud : [luuletused] / Karl Ast Rumor

Index Scriptorium Estoniae

Ast Rumor, Karl

2007-01-01

Sisu : Meie ja nemad ; Öisel teel ; Luikede laul ; Crescendo ; Needmine ; Bajazzo ; Kurbtus ; Minevikule ; Tunnistus ; Punased lilled. Varem ilmunud ""Edasi" jõulualbum 4". Tallinn 1911 ; "Meie Sõna 1". Tallinn 1911

Terved mullad - terveks eluks / kokkuvõtte tegi Airi Vetemaa

Index Scriptorium Estoniae

2015-01-01

ÜRO on kuulutanud 2015. aasta rahvusvaheliseks mulla-aastaks. Meie mullad on kogu inimeksistentsi aluseks - see sisuliselt taastumatu loodusvara annab 95% meie toidust. Eesti aasta muld 2015 on paepealne muld

Gibberellin-induced change in the structure of chromatin in wheat sprouts: decrease in the accessibility of DNA in preparations of soluble chromatin to the action of EcoRII methylase

International Nuclear Information System (INIS)

Noskov, V.A.; Kintsurashvili, L.N.; Smirnova, T.A.; Manamsh'yan, T.A.; Kir'yanov, G.I.; Vanyushin, B.F.

1986-01-01

A method has been perfected for producing soluble chromatin from whole wheat sprouts at low ionic strength. The chromatin preparations isolated possess a native structure: they have a nucleosome organization. Under identical conditions the soluble wheat chromatin undergoes more profound degradation by DNase I and staphylococcal nuclease than the chromatin from the rat liver. The DNA contained in the isolated chromatin is capable of accepting CHnumber groups from S-[methyl- 3 H]-adenosylmethionine during incubation with DNA methylase EcoRII; not all the CC A/T GG sequences in DNA are methylated in vivo. Chromatin from gibberellin A 3 -treated wheat sprout DNA accepts 40% fewer CH 3 groups than that from the control sprouts, which is probably due to the greater compactness of the chromatin. In the case of longer incubation, the level of methylation of the chromatin falls, which may be associated with the presence of DNA-demethylating activity

Lennart Meri : kõige kaunim on naeratav Eesti / Lennart Meri

Index Scriptorium Estoniae

Meri, Lennart, 1929-2006

1994-01-01

Presidendi uusaastaläkitus 31. detsembril 1993. Ilmunud ka ajalehtedes : Meie Elu = Our Life, 6. jaan., lk. 1, 8 ; Vaba Eestlane = Free Estonian, 6. jaan., lk. 1, 3 ; Meie Kodu = Our Home, 12. jaan., lk. 2

Radioimmunoimaging of ovarian cancer with 131I labelled CEA monoclonal antibody

International Nuclear Information System (INIS)

Hu Likuan; Li Zhen; Huo Zhenguo; Jiang Sen; Jia Shiquan

2001-01-01

Objective: To investigate radioimmunoimaging with 131 I labelled CEA McAb and its value in diagnosis and treatment of ovarian cancer. Methods: CEA McAb was labelled with 131 I by standard chloramine T procedure. The radiolabeled McAb was given intravenously to the patients. The scintigraphy was performed at different time. Results: In 105 patients with histopathology proved ovarian cancers, for 96 patients the lesions were well located with RII (true positives), for the remaining 9 patients, the results were false negative. 22/23 cases with RII diagnosed benign ovarian tumors were proved to be true negative by surgical pathology in RII. Of 96 ovarian cancers 87 were stratified into identical stages by surgical pathology all RII. 141/151 metastatic tumors were found in RII and the positive rate was as high as 93.4%. The smallest tumor defected by RII was of 1 cm in diameter. Conclusions: RII is as good as ultrasonography and CT in distinguishing benignancy and malignancy. The location, size and number of the lesions can also be determined with RII. RII of ovarian cancer with 131 I-CEA McAb is valuable and helpful in early detection of ovarian cancer. It is also helpful for clinical staging, treatment programing and prognosticating

Eesti julgeoleku tagab üksnes usaldusväärsus : Vabariigi Presidendi Lennart Meri kõne Estonia kontserdisaalis 24. veebruaril 1995 / Lennart Meri

Index Scriptorium Estoniae

Meri, Lennart, 1929-2006

1995-01-01

Eesti Vabariigi 77 aastapäev. Kõne on ilmunud ka: Päevaleht, 27. veebr. 1995, lk. 1, 6, pealkiri: Eelseisvad valimised kindlustagu poliitika järjepidevust; Eesti Sõnumid, 27. veebr. 1995, lk. 3, pealkiri: "Meie raskemad ajad on nüüd tõepoolest selja taga"; Hommikuleht, 27. veebr. 1995, lk. 2, 5, pealkiri: Raskemad ajad on seljataga; Postimees, 27. veebr., lk. 2, 6, pealkiri: President Lennart Meri kõne Estonia kontserdisaalis 24. veebruaril 1995; Meie Elu, 2. märts, lk. 10; Meie Kodu, 8. märts, lk. 5

The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor

DEFF Research Database (Denmark)

Atfi, Azeddine; Dumont, Emmanuelle; Colland, Frédéric

2007-01-01

Transforming growth factor-beta (TGF-beta) regulates a wide variety of biological processes through two types of Ser/Thr transmembrane receptors: the TGF-beta type I receptor and the TGF-beta type II receptor (TbetaRII). Upon ligand binding, TGF-beta type I receptor activated by TbetaRII propagat......RII protein presumably by suppressing the association of TbetaRII with Smad7. These results define ADAM12 as a new partner of TbetaRII that facilitates its trafficking to early endosomes in which activation of the Smad pathway is initiated....

Eestlased võitsid enim kuldseid haamreid / Hando Sinisalu

Index Scriptorium Estoniae

Sinisalu, Hando, 1970-

2004-01-01

Riia rahvusvaheline Baltikumi reklaamifestival Golden Hammer. Festivali taset kommenteerivad žürii esimees Peeter Kandimaa ja žürii liige Rein Iida Eestist ning žürii liige Aleksei Golikov Venemaalt

Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer

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Koni Ivanova

2018-03-01

Full Text Available BACKGROUND: Papillary thyroid carcinoma (PTC accounts for 80% of the thyroid malignancies that are characterised by slow growth and an excellent prognosis. Over-expression of SMAD4 protein restores TGF-β signalling, determines a strong increase in anti-proliferative effect and reduces invasive potential of tumour cells expressing it. AIM: The study aimed to analyse the immunohistochemical expression of TGF-β1 and its downstream phosphorylated SMAD4, element and of the inhibitory SMAD7 PTC variants and their association with the localisation of TAMs within the tumour microenvironment. METHODS: For this retrospective study we investigated 69 patients immunohistochemistry with antibodies against TGF-β, TGF – β-RII, SMAD4, SMAD7, CD68+ macrophages. RESULTS: Patients with low infiltration with CD68+ cells in tumour stroma has significantly shorter survival (median of 129.267 months compared to those with high CD68+ cells infiltration (p = 0.034. From the analysis of CD68+ cells in tumour border and tumour stroma correlated with expression of TGF-β1 / SMAD proteins, we observed that the positive expression of TGF-β1 in tumour cytoplasm, significantly correlated with increased number of CD68+ cells in tumour border (X2 = 5,945; р = 0.015. CONCLUSION: TGF-β enhances motility and stimulates recruitment of monocytes, macrophages and other immune cells while directly inhibiting their anti-tumour effector functions.

METODOLOGIA CERCETĂRII ŞTIINŢIFICE – MODELE REPREZENATIVE INTERDISCIPLINARE LANSATE DE K.POPPER ŞI G.BACHELARD

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Vasile ŢAPOC

2018-05-01

Full Text Available În articol sunt abordate posibilităţile investigaţionale ale modelelor elaborate de K.Popper şi G.Bachelard, ce se înscriu în orizontul cercetării interdisciplinare. Atât metoda raţionalismului critic a lui K.Popper, cât şi metoda recurentă a lui G.Bachelard utilizează din plin resursele cunoaşterii raţionale, obiective. Anume natura acesteia a permis transfor­marea metodologiei interdisciplinare în tehnologie de producere a cunoştinţelor prin computere, fapt ce a dus la pro­gresul civilizaţiei, concomitent cu criza culturii. Specialistul, în inter­de­pendenţă cu computerul, a devenit instrument comod în rezolvare a problemelor civilizaţionale, omul, însă, cu problemele sale legate de cultură: finalitatea existenţei, realizarea de sine spirituală ş.a., este pus în sarcina­ cercetărilor transdisciplinare.THE METHODOLOGY OF SCIENTIFIC RESEARCH – REPRESENTATIVE INTERDISCIPLINARY MODELS, INTRODUCED BY K.POPPER AND G.BACHELARDThe current article focuses on possibilities of research offered by the models, developed by K.Popper and G.Bachelard, as placed in the sphere of interdisciplinary study. Both the method of critical rationalism by K.Popper, as well as the recurrent method of G.Bachelard use abundantly the resources of rational, objective knowledge. It is the nature of the latter that allowed for the transformation of interdisciplinary methodology into a technology of knowledge production by computers, which lead to the progress of civilization, along with the crisis of culture. A specialist in computer interdependency has become a convenient tool in solving civilization problems, whereas the man overwhelmed by his cultural problems – the finality of his existence and others – falls into the realm of interdisciplinary research.

Koolis möödunud festival eelistas lapsi / Merit Kask, Liisi Poll

Index Scriptorium Estoniae

Kask, Merit

2003-01-01

Lõppenud Pärnu XVII dokumentaal- ja antropoloogiafilmide festivalist. Lisaks avaldavad oma arvamust rahvusvahelise žürii esimees John Russel Taylor, žürii liige Tiina Lokk ja eesti dokumentaalfilmide žürii esimees Tõnis Kask. Lisatud auhinnasaajate nimekiri

An antisense oligodeoxynucleotide targeted against the type IIβ regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects

International Nuclear Information System (INIS)

Tortora, G.; Clair, T.; Cho-Chung, Y.S.

1990-01-01

The type II β regulatory subunit of cAMP-dependent protein kinase (RII β ) has been hypothesized to play an important role in the growth inhibition and differentiation induced by site-selective cAMP analogs in human cancer cells, but direct proof of this function has been lacking. To address this tissue, HL-60 human promyelocytic leukemia cells were exposed to RII β antisense synthetic oligodeoxynucleotide, and the effects on cAMP-induced growth regulation were examined. Exposure of these cells to RII β antisense oligodeoxynucleotide resulted in a decrease in cAMP analog-induced growth inhibition and differentiation without apparent effect on differentiation induced by phorbol esters. This loss in cAMP growth regulatory function correlated with a decrease in basal and induced levels of RII β protein. Exposure to RII β sense, RI α and RII α antisense, or irrelevant oligodeoxynucleotides had no such effect. These results show that the RII β regulatory subunit of protein kinase plays a critical role in the cAMP-induced growth regulation of HL-60 leukemia cells

Functional transforming growth factor-β receptor type II expression by CD4+ T cells in Peyer's patches is essential for oral tolerance induction.

Directory of Open Access Journals (Sweden)

Rebekah S Gilbert

Full Text Available Our previous studies have shown that Peyer's patches (PPs play a key role in the induction of oral tolerance. Therefore, we hypothesized that PPs are an important site for Transforming Growth Factor (TGF-β signaling and sought to prove that this tissue is of importance in oral tolerance induction. We found that expression of TGF-β type II receptor (TGFβRII by CD4(+ T cells increases and persists in the PPs of normal C57BL/6 mice after either high- or low-dose feeding of OVA when compared to mesenteric lymph nodes (MLNs and spleen. Approximately one-third of these TGFβRII(+ CD4(+ T cells express the transcription factor Foxp3. Interestingly, the number of TGFβRII(+ CD4(+ T cells in PPs decreased when OVA-fed mice were orally challenged with OVA plus native cholera toxin (CT. In contrast, numbers of TGFβRII(+ CD4(+ T cells were increased in the intestinal lamina propria (iLP of these challenged mice. Further, these PP CD4(+ TGFβRII(+ T cells upregulated Foxp3 within 2 hours after OVA plus CT challenge. Mice fed PBS and challenged with OVA plus CT did not reveal any changes in TGFβRII expression by CD4(+ T cells. In order to test the functional property of TGFβRII in the induction of oral tolerance, CD4dnTGFβRII transgenic mice, in which TGFβRII signaling is abrogated from all CD4(+ T cells, were employed. Importantly, these mice could not develop oral tolerance to OVA. Our studies show a critical, dose-independent, role for TGFβRII expression and function by CD4(+ T cells in the gut-associated lymphoid tissues, further underlining the vital role of PPs in oral tolerance.

Huvitavat lisa Austraaliast Eesti mäluasutustele / Anne Valmas

Index Scriptorium Estoniae

Valmas, Anne, 1941-2017

2007-01-01

Eesti Arhiiv Austraalias säilitab meie kultuurile olulist vaimuvara - trükiseid, käsikirju, fotosid, filme, mälestusesemeid. Näitusest Sydney Powerhouse Museumìs "Our new home - Meie uus kodu: Estonian-Australian Stories", kus eksponaatidena kasutati arhiivi materjale, näitusest Wollondilly kultuuripärandi keskuses

EFICIENȚA APLICĂRII STANDARDELOR INTERNAȚIONALE DE RAPORTARE FINANCIARĂ (IFRS ÎN REPUBLICA MOLDOVA, ÎN CONDIȚIILE ACTUALE ALE ECONOMIEI DE PIAȚĂ

Directory of Open Access Journals (Sweden)

Svetlana MIHAILA

2018-03-01

Full Text Available În acest articol autorii își propun să furnizeze informații privind aplicabilitatea Standardelor Internaționale de Raportare Financiară (International Financial Reporting Standards (IFRS în Republica Moldova, având în vedere condițiile actuale ale economiei de piață. Mesajul acestui articol este definit de prezentarea unor situații, prin care se observă avantajele potențiale privind implementarea IFRS, privită din punctul de vedere al necesității. Totodată, sunt relatate și unele lacune posibile, în urma aplicării standardelor internaționale, ce s-ar referi la complicitate, costuri și concoradanță a informației.THE EFFICIENCY OF INTERNATIONAL FINANCIAL REPORTING STANDARDS APPLICATION IN REPUBLIC OF MOLDOVA IN THE CURRENT MARKET ECONOMY CONDITIONSIn this article the authors aim to provide information regarding the International Financial Reporting Standards inRepublicofMoldova, taking into account the current market economy conditions. The message of this article is to present some situations, by which can be noted the potential advantages on implementing IFRS, looking in terms of necessity. Also, are reported the possible gaps, after applying international standards, that would mean complicity, costs, and consistency of information. 

Siin ei ole kala, on kormoranid / Marianne Mikko

Index Scriptorium Estoniae

Mikko, Marianne, 1961-

2008-01-01

Kormoranide, kes on Euroopa Liidu linnudirektiivi kaitse all, tekitatud kahjust ning nende arvukuse piiramisest kaitsmaks meie kalavarusid ja loodust. Ilmunud ka Meie Maa 21. juuli 2008, lk. 2 ; Põhjarannik 24. juuli 2008, lk. 2 ; Koit 24. juuli 2008, lk. 6 ; Harju Ekspress 25. juuli 2008, lk. 7 ; Vooremaa 31. juuli 2008, lk. 2

ESL aastapreemia 2009 žürii koosoleku protokoll = The Estonian Society of Interior Architects annual prize 2009 - minutes of the jury meeting = Протокол собрания жюри о присуждении премии Эстонского �

Index Scriptorium Estoniae

2010-01-01

Eesti Sisearhitektide Liidu aastapreemia 2009 žürii otsustas 1. märtsil 2010. a. välja anda ühiskondliku interjööri (Eesti Maaülikooli spordihoone), büroo interjööri (Baltika bürooruumid), kaupluse interjööri (Apollo raamatupood) ja ajaloolise interjööri (Röa pargipaviljon) preemia

Linlased saavad valida Tallinna uut logo / Askur Alas

Index Scriptorium Estoniae

Alas, Askur, 1973-

2005-01-01

Tallinna logo konkursist. Rahvusvahelise žürii poolt valitud 10 finalisti pluss Aavo Ermeli poolt 2003. a. kavandatud logo on hindamiseks veebilehel logo.tallinn.ee. Ermeli logo "mineoletulevik" on praegu kasutusel. Finalistidele annavad hinnangu linnavalitsuse liikmed, rahvusvaheline žürii ja tallinlased SMS-hääletuse teel. Žürii koosseis. Lisatud 11 kavandit

REFLECŢII PRIVIND ROLUL FORMĂRII PROFESIONALE A FACTORILOR RESPONSABILI DE SECURITATEA ŞI SĂNĂTATEA ÎN MUNCĂ

Directory of Open Access Journals (Sweden)

Ioan POPESCU

2017-01-01

Full Text Available În articol este cercetată formarea profesională a persoanelor responsabile de securitatea şi sănătatea în muncă în România. În acest context s-a făcut referire la legislaţia naţională, la legislaţia europeană ce trateză această temă. De asemenea, au fost analizate metodele şi procedeele moderne ce ţin de educarea şi formarea profesională care, ca urmare, trebuie să asigure însuşirea unor cunoştinţe avansate, necesare pentru îndeplinirea sarcinilor de serviciu în siguranţă. S-a făcut referire la consecinţele accidentelor de muncă, care pot invoca vătămări violente ale organismului lucrătorilor, afectări ale stării de sănătate, afectări ale mediului înconjurator, producerea unor pagube materiale, pierderi de imagine pentru firme etc.REFLECTIONS ON PROFESSIONAL FORMATION ROLE OF RESPONSIBLE FACTORS FOR SAFETY AND HEALTH AT WORKThis article investigates the professional formation of persons responsible for safety and health at work in Romania. In this context there was made reference to national and European legislation that treats this subject. Also were analyzed modern methods and techniques related to education and training, that should ensure as a result acquiring advanced knowledge required for fulfilling their duties safely. Here was also mentioned the consequences of accidents at work that can invoke violent injuries of the employees’ body, impairment of health, impairment of the environment, property damage, loss of image for companies, etc.

FcγRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody.

Science.gov (United States)

Zhang, Di; Whitaker, Brian; Derebe, Mehabaw G; Chiu, Mark L

2018-04-01

Immunostimulatory antibodies against the tumor necrosis factor receptors (TNFR) are emerging as promising cancer immunotherapies. The agonism activity of such antibodies depends on crosslinking to Fc gamma RIIB receptor (FcγRIIB) to enable the antibody multimerization that drives TNFR activation. Previously, Fc engineering was used to enhance the binding of such antibodies to Fcγ receptors. Here, we report the identification of Centyrins as alternative scaffold proteins with binding affinities to homologous FcγRIIB and FcγRIIA, but not to other types of Fcγ receptors. One Centyrin, S29, was engineered at distinct positions of an anti-OX40 SF2 antibody to generate bispecific and tetravalent molecules named as mAbtyrins. Regardless of the position of S29 on the SF2 antibody, SF2-S29 mAbtyrins could bind FcγRIIB and FcγRIIA specifically while maintaining binding to OX40 receptors. In a NFκB reporter assay, attachment of S29 Centyrin molecules at the C-termini, but not the N-termini, resulted in SF2 antibodies with increased agonism owing to FcγRIIB crosslinking. The mAbtyrins also showed agonism in T-cell activation assays with immobilized FcγRIIB and FcγRIIA, but this activity was confined to mAbtyrins with S29 specifically at the C-termini of antibody heavy chains. Furthermore, regardless of the position of the molecule, S29 Centyrin could equip an otherwise Fc-silent antibody with antibody-dependent cellular phagocytosis activity without affecting the antibody's intrinsic antibody-dependent cell-meditated cytotoxicity and complement-dependent cytotoxicity. In summary, the appropriate adoption FcγRII-binding Centyrins as functional modules represents a novel strategy to engineer therapeutic antibodies with improved functionalities.

Rational Development of Malaria Vaccines Chetan Chitnis ICGEB ...

Indian Academy of Sciences (India)

Anti-PvRII Blocking Abs are Associated with Delay in Time to Re-infection with P. vivax but not P. falciparum · High Anti-PvRII Blocking Abs are Associated with Reduction in P. vivax Parasite Density · High Anti-PvRII Blocking Abs are Associated with Reduction in P. vivax Parasite Density but not P. falciparum Parasite ...

Ühendatud inimeste üksindus / Martin Ehala

Index Scriptorium Estoniae

Ehala, Martin, 1963-

2007-01-01

Vastukaja art.: Sutrop, Margit. Vabadus ja vastutus // Postimees : AK : Arvamus. Kultuur (2007) 20. jaan. Artikli autor Martin Ehala selgitab, miks laguneb lääne ühiskondades sotsiaalne kapital ja kaob ühiskonda liitev meie-tunne. Kolmest olulisest sotsiaalsest nähtusest : individualismist, kollektivismist ja sotsiaalsest kapitalist. Üks olulisemaid tingimusi meie-tunde arenemiseks on ühiste väärtuste olemasolu

Radioimmunoimaging of 99mTc-OC125 on experimental research and clinical application of ovarian cancer

International Nuclear Information System (INIS)

Zhang Hong; Xu Huimin; Wu Jinchang

2000-03-01

The objective of research is to investigate radioimmunoimaging (RII) on ovarian tumor by labelling anti-ovarian cancer monoclonal antibody (OC125) with 99m Tc. the nude mice models were produced by injection ovarian serous cyst adenocarcinoma cell HO8910. Experimental group was injected with 99m Tc-OC125 as tracer and control groups were injected normal mice IgG labelled with 99m Tc and anti-HO8910 antibody labelled with 99m Tc. RII using 99m Tc-OC125 McAb was also performed on 4 nude mice model of glioma (control group). Imaging positive rate, negative rate and tumor/non-tumor ratio were calculated. Results show positive rate of imaging of tumor was 100%. The most distinct pictures were gained between 4 to 6 h after injection of tracer. T/NT ratios of experimental group were higher than that of control groups (P 99m Tc on the nude mice models was sensitive and specific. 16 ovarian neoplasm patients were received RII 6 h after intravenous injected OC125 McAb labelled with 99m Tc. Four patients of malignant tumor repeated RII after operation and chemotherapy. The result of RII was accorded perfectly with operation. RII also can find micro recurrence focus of post-operation. The sensitivity and specificity was more excellent than the radioimmunoassay of CA125. RII is useful for defining character of ovarian tumor, especially for detecting early recurrence focus of post-operation patients

Meie oma Berlinale

Index Scriptorium Estoniae

2005-01-01

Filmistuudio Parunid ja Vonid stuudios realiseerus EFSi, Kultuurkapitali, TPÜ ja Parunite ja Vonide ühisprojekt "Ground Zero", mille tulemuseks on TPÜ filmi ja video õppetooli tudengite lühimängufilmid (juhendaja Jüri Sillart)

Meie mees Microsoftis

Index Scriptorium Estoniae

2004-01-01

1999. aastast töötab Eestist pärit Margus Veanes Microsofti tarkvara testimise laboris Redmondis teadurina, luues uusi kontseptsioone, kuidas tarkvaras leiduvaid vigu juba eos leida ja likvideerida

Meie staarid raadioteatris

Index Scriptorium Estoniae

2005-01-01

Raivo Küti raadioetenduses "Papa" teeb oma esimese kuuldemängu rolli Ülle Lichtfeldt. August Gailiti novelli "Seeba kuninganna" järgi loodavas kuuldemängus "Toomas Nipernaadi talv" saab kuulda peaosas Üllar Saaremäed

Vabadus ise mõelda / Olav Aarna

Index Scriptorium Estoniae

Aarna, Olav, 1942-

2005-01-01

Ilmunud ka: Lääne Elu 31. mai, lk. 2, Põhjarannik 31. mai, lk. 2, Severnoje Poberezhje 31. mai, lk. 2, Meie Maa 31. mai, lk.2, Sakala 1. juuni lk. 2, Nädaline, Lõunaleht, Koit 2. juuni lk. 2,2,6, Kuulutaja 3. juuni lk. 4, Valgamaalane 4. juuni lk. 2. Kordusartikkel Meie Maa 15. juuni lk. 2. Kahest Res Publica poolt algatatud eelnõust koolikorralduse muutmiseks

PREZICEREA PERFORMANŢELOR STUDENŢILOR FOLOSIND ÎNVĂŢAREA AUTOMATĂ (Machine Learning)

OpenAIRE

Maria CRISTEI; Ghenadie MARIN; Victor STELEA

2017-01-01

În prezent, învăţarea automată (machine learning) ocupă un loc important în inteligenţa artificială, preocupându-se de dezvoltarea algoritmilor ce permit unui sistem informatic să înveţe date, reguli şi algoritmi. Învăţarea automată pre­supune în primul rând identificarea şi implementarea unei modalităţi cât mai eficiente de reprezentare a informaţiilor, în sensul facilitării căutării, reorganizării şi modificării acestora. În acest sens, în prezentul articol se descrie utilitatea şi aplicabi...

ESL aastapreemia konkurss 2010. Žürii koosoleku protokoll = ESL awards 2010. Minutes of the meeting of the panel of judges = Конкурс на соискание премии ESL за 2010 год. Протокол собрания жюри

Index Scriptorium Estoniae

2011-01-01

Eesti Sisearhitektide Liidu aastapreemia 2010 žürii otsustas 7. aprillil 2011. a. välja anda söögikoha interjööri (kohvik Supelsaksad), ühiskondliku interjööri (ADM Interactive'i büroo), ajaloolise interjööri (Kihnu muuseum) ning näituse ja installatsiooni kujunduse (välinäitus "Eesti kirjanikud karikatuuris") preemia. Tudengipreemia: Aet Tera

ESL aastapreemia konkurss 2011. Žürii koosoleku protokoll = ESL awards 2011. Minutes of the meeting of the panel of judges = Конкурс на соискание премии ESL за 2011 год. Протокол собрания жюри

Index Scriptorium Estoniae

2012-01-01

Eesti Sisearhitektide Liidu aastapreemia žürii otsustas välja anda ühiskondliku interjööri (Tartu Tervishoiu Kõrgkool), ajaloolise interjööri (Peterburi Jaani kirik), "Väikese ruumi" (Järvamaa turismiinfokeskus), publitsistika (raamat "Tööraamat") ning näituse ja installatsiooni kujunduse (näitus "Pavel Filonov. Vene avangard ja järgnenu ..." Kumu Kunstimuuseumis"") preemia. Tudengipreemia pälvis Tuuli Trei

Nonlinear Filtering Effects of Reservoirs on Flood Frequency Curves at the Regional Scale: RESERVOIRS FILTER FLOOD FREQUENCY CURVES

Energy Technology Data Exchange (ETDEWEB)

Wang, Wei; Li, Hong-Yi; Leung, Lai-Yung; Yigzaw, Wondmagegn Y.; Zhao, Jianshi; Lu, Hui; Deng, Zhiqun; Demissie, Yonas; Bloschl, Gunter

2017-10-01

Anthropogenic activities, e.g., reservoir operation, may alter the characteristics of Flood Frequency Curve (FFC) and challenge the basic assumption of stationarity used in flood frequency analysis. This paper presents a combined data-modeling analysis of the nonlinear filtering effects of reservoirs on the FFCs over the contiguous United States. A dimensionless Reservoir Impact Index (RII), defined as the total upstream reservoir storage capacity normalized by the annual streamflow volume, is used to quantify reservoir regulation effects. Analyses are performed for 388 river stations with an average record length of 50 years. The first two moments of the FFC, mean annual maximum flood (MAF) and coefficient of variations (CV), are calculated for the pre- and post-dam periods and compared to elucidate the reservoir regulation effects as a function of RII. It is found that MAF generally decreases with increasing RII but stabilizes when RII exceeds a threshold value, and CV increases with RII until a threshold value beyond which CV decreases with RII. The processes underlying the nonlinear threshold behavior of MAF and CV are investigated using three reservoir models with different levels of complexity. All models capture the non-linear relationships of MAF and CV with RII, suggesting that the basic flood control function of reservoirs is key to the non-linear relationships. The relative roles of reservoir storage capacity, operation objectives, available storage prior to a flood event, and reservoir inflow pattern are systematically investigated. Our findings may help improve flood-risk assessment and mitigation in regulated river systems at the regional scale.

Project Management – Multi-perspective Leadership

DEFF Research Database (Denmark)

Riis, Eva

2014-01-01

”Project Management – Multi-perspective Leadership” af Hans Mikkelsen og Jens Ove Riis - anmeldelse......”Project Management – Multi-perspective Leadership” af Hans Mikkelsen og Jens Ove Riis - anmeldelse...

Eesti väärib paremat / Jaak Aaviksoo

Index Scriptorium Estoniae

Aaviksoo, Jaak, 1954-

2006-01-01

Ilmunud ka: Virumaa Teataja, Põhjarannik, Severnoje Poberezhje, Meie Maa, Vooremaa 3. okt. lk. 11,2,2,2,2, Sakala, Pärnu Postimees, Sõnumitooja 4. okt. lk. 2,15,2, Lõunaleht 5. okt. lk. 2, Kuulutaja, Vali Uudised 6. okt. lk. 6,2, Järva Teataja 7. okt. lk. 2. Autori sõnul on Eestis tajutav usalduskriis, mille põhjuseks on eetiliste piiride kadumine meie poliitilistest otsustest. Ta toob välja kolm arenguprioriteeti riigi edasiseks arenguks

Eesti ei tohi jääda odava tööjõuga maaks / Kadi Pärnits

Index Scriptorium Estoniae

Pärnits, Kadi, 1965-

2004-01-01

Ilmunud ka: Severnoje Poberezhje, 3. apr. 2004, lk. 2; Hiiu Leht, 6. apr. 2004, lk. 2; Krengolmskii Prospekt, 13. apr. 2004, lk. 2; Narvskaja Gazeta, 17. apr. 2004, lk. 5; Sillamjaeskii Vestnik, 20. apr. 2004, lk. 1. Eesti valitsuse madalate palkade poliitikast ja lubadusest tuua Eestisse suurel hulgal odavat võõrtööjõudu. Sotsiaaldemokraatliku Erakonna arvates peab kaitsma meie tööturgu ning meie eesmärgiks peab olema euroopaliku palgataseme saavutamine

Tartus veeresid Kuldmunad ja Kandilised Munad / Liivi Shein

Index Scriptorium Estoniae

Šein, Liivi

2007-01-01

"Kuldmuna 2007" võistlusel hinnati seekord reklaami- ja disainitöid eraldi. Aasta agentuuriks tunnistati reklaamibüroo Division. Reklaamivõistluse žürii esimees Urmas Lilleorg, disaini žürii eesotsas Margus Klaar

Eesti Energia esindused = Eesti Energia branches / Andres Labi, Janno Roos

Index Scriptorium Estoniae

Labi, Andres, 1977-

2013-01-01

Eesti Energia klienditeeninduse kontorite sisekujundusest. Autorid: Janno Roos, Andres Labi ja Liisa Põime (Ruumilabor). Visuaalne identiteet: Tank.Teenuste disain: Urmas Pastarus. ESLi aastapreemiate žürii esimehe Kaido Kivi ning žürii liikme Raivo Puusepa arvamused

Kust saadakse eestlasi? / Ago Teder

Index Scriptorium Estoniae

Teder, Ago, 1933-

2001-01-01

Järgneb: Meie Maa, 18. juuli 2001. Ilmunud ka: Koit, 6. nov. 2001, lk. 6; 8. nov. 2001, lk. 6; 10. nov. 2001, lk. 6; Vooremaa, 24. nov. 2001, lk. 4; 6. dets. 2001, lk. 4; 8. dets. 2001, lk. 4. Eestlaste iibest. Lasterikaste perede olukord. Hariduskulude tõustes sündimus väheneb. Massimeedia on distantseerunud perekonna- ja lasteteemast. Tabelid. Vt. samas art. Meie Maa, 31. aug. 2001, lk. 6. Komment. J. Ligi, A. Altosaar, G. Raagmaa. Parlamendisaadik

Effects of TGF-β signaling blockade on human A549 lung adenocarcinoma cell lines.

Science.gov (United States)

Xu, Cheng-Cheng; Wu, Lei-Ming; Sun, Wei; Zhang, Ni; Chen, Wen-Shu; Fu, Xiang-Ning

2011-01-01

Transforming growth factor β (TGF-β) is overexpressed in a wide variety of cancer types including lung adenocarcinoma (LAC), and the TGF-β signaling pathway plays an important role in tumor development. To determine whether blockade of the TGF-β signaling pathway can inhibit the malignant biological behavior of LAC, RNA interference (RNAi) technology was used to silence the expression of TGF-β receptor, type II (TGFβRII) in the LAC cell line, A549, and its effects on cell proliferation, invasion and metastasis were examined. Three specific small interfering RNAs (siRNAs) designed for targeting human TGFβRII were transfected into A549 cells. The expression of TGFβRII was detected by Western blot analysis. Cell proliferation was measured by MTT and clonogenic assays. Cell apoptosis was assessed by flow cytometry. The invasion and metastasis of A549 cells were investigated using the wound healing and Matrigel invasion assays. The expression of PI3K, phosphorylated Smad2, Smad4, Akt, Erk1/2, P38 and MMPs was detected by Western blot analysis. The TGFβRII siRNA significantly reduced the expression of TGFβRII in A549 cells. The knockdown of TGFβRII in A549 cells resulted in the suppression of cell proliferation, invasion and metastasis and induced cell apoptosis. In addition to the Smad-dependent pathway, independent pathways including the Erk MAPK, PI3K/Akt and p38 MAPK pathways, as well as the expression of MMPs and VEGF, were inhibited. In conclusion, TGF-β signaling is required for LAC progression. Therefore, the blockade of this signaling pathway by the down-regulation of TGFβRII using SiRNA may provide a potential gene therapy for LAC.

Cognitive ability, parental socioeconomic position and internalising and externalising problems in adolescence: Findings from two European cohort studies

International Nuclear Information System (INIS)

Huisman, Martijn; Araya, Ricardo; Lawlor, Debbie A.; Ormel, Johan; Verhulst, Frank C.; Oldehinkel, Albertine J.

2010-01-01

We investigated whether cognitive ability (CA) may be a moderator of the relationship of parental socioeconomic position (SEP) with internalising and externalising problems in adolescents. We used data from two longitudinal cohort studies; the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Tracking Adolescents' Individual Lives Survey (TRAILS). Indicators of SEP were mother's education and household income. CA was estimated with IQ scores, derived from the Wechsler Intelligence Scale for Children. Internalising and externalising problems were measured with the Strengths and Difficulties Questionnaire in ALSPAC and with the Child Behavior Checklist in TRAILS. Logistic regression analyses were used to estimate the relative index of inequality (RII) for each outcome; the RII provides the odds ratio comparing the most to least deprived for each measure of SEP. In fully adjusted models an association of mother's education with externalising problems was observed [ALSPAC RII 1.42 (95%CI: 1.01-1.99); TRAILS RII 2.21 (95%CI: 1.37-3.54)], and of household income with internalising and externalising problems [pooled ALSPAC and TRAILS internalising RII 1.30 (95%CI: 0.99-1.71); pooled ALSPAC and TRAILS externalising RII 1.38 (95%CI: 1.03-1.84)]. No consistent associations were observed between mother's education and internalising problems. Results of stratified analyses and interaction-terms showed no evidence that CA moderated the association of SEP with internalising or externalising problems.

The clinical application of radioimmunoimaging with 99mTc labeled anti-CEA monoclonal antibody C50

International Nuclear Information System (INIS)

Jiang Ningyi; Sha Xiaozhen; Zhang Hua

1996-01-01

To evaluate the clinical value of the radioimmunoimaging (RII) for the diagnosis of tumor with 99m Tc labeled anti-CEA monoclonal antibody C50, C50 was labeled with 99m Tc using modified 2-mercaptoethanol method. 99m Tc-C50 RII was performed in 70 patients with tumor. All were pathologically proved after operation. The sensitivity of 99m Tc-C50 RII for tumor was 82.9%, the specificity was 86.2%, the false negative rate was 17.1%, and the false positive rate was 13.8%. The positive predictive value was 89.5%, the negative predictive value was 78.1%. The coincidence rates was 82.4%, 84.6% and 80.0% for the ovarial intestinal and lung tumor respectively. 99m Tc-C50 RII was useful in clinical diagnosis of tumor

Intriigid, edevus ja raudsed närvid / Triin Thalheim

Index Scriptorium Estoniae

Thalheim, Triin, 1982-

2006-01-01

Tõsielusarjast "Ameerika supermodell", mida alustati 2003. a. Saatejuht, sarja üks produtsent ja modelle hindava žürii liige on ameerika tippmodell Tyra Banks. Seitsmendal hooajal on žüriis endise supermodelli Janice Dickinsoni asemel 1960-ndate supermodell Twiggy

Aiamaja = Residential building in Aia street / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas vanalinna piiril Vana-Viru 13/Aia 4 asuva elamu arhitektuursest lahendusest. Arhitektid: Villem Tomiste, Ott Kadarik, Mihkel Tüür (AB Kosmos). Ajaloolane Liivi Künnapu. Žürii liige Kalle Komissarovi žürii hinnangust kultuurkapitali aastapreemiale esitatud hoonele

Ebavõrdsus hukutab Eesti arengu / Katrin Saks

Index Scriptorium Estoniae

Saks, Katrin, 1956-

2004-01-01

Ilmunud ka: Pärnu Postimees, 22. jaan. 2004, lk. 11; Võrumaa Teataja, 24. jaan. 2004, lk. 2; Meie Maa, 24. jaan. 2004, lk. 2; Hiiu Leht, 27. jaan. 2004, lk. 2; Põhjarannik, 31. jaan. 2004, lk. 2; Severnoje Poberezhje, 31. jaan. 2004, lk. 2; Koit, 3. veebr. 2004, lk. 6; Hiiumaa, 3. veebr. 2004, lk. 2. Autor vaatleb riigi osa ebavõrduse ilmingute likvideerimisel Eestis ja leiab, et ebavõrdsus on meie arengu peamine takistus, mille kõrvaldamine on sotsiaaldemokraatide peamine eesmärk

Viljandi sõudeelling = Viljandi Rowing Slipway / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Viljandis Ranna pst. 13 asuva sõudeellingu arhitektuursest lahendusest. Arhitektid Lauri Saar, Toomas Paaver, Indrek Järve (Paik Arhitektid OÜ), kaasautorid Jaak-Adam Looveer, Tõnu Laanemäe. Žürii liige Kalle Komissarov žürii hinnangust kultuurkapitali aastapreemiale esitatud ehitisele

Downregulation of TGF-beta receptor types II and III in oral squamous cell carcinoma and oral carcinoma-associated fibroblasts

International Nuclear Information System (INIS)

Meng, Wenxia; Xia, Qingjie; Wu, Lanyan; Chen, Sixiu; He, Xin; Zhang, Lin; Gao, Qinghong; Zhou, Hongmei

2011-01-01

The purpose of this study was to assess the expression levels for TβRI, TβRII, and TβRIII in epithelial layers of oral premalignant lesions (oral leukoplakia, OLK) and oral squamous cell carcinoma (OSCC), as well as in oral carcinoma-associated fibroblasts (CAFs), with the final goal of exploring the roles of various types of TβRs in carcinogenesis of oral mucosa. Normal oral tissues, OLK, and OSCC were obtained from 138 previously untreated patients. Seven primary human oral CAF lines and six primary normal fibroblast (NF) lines were established successfully via cell culture. The three receptors were detected using immunohistochemical (IHC), quantitative RT-PCR, and Western blot approaches. IHC signals for TβRII and TβRIII in the epithelial layer decreased in tissue samples with increasing disease aggressiveness (P < 0.05); no expression differences were observed for TβRI, in OLK and OSCC (P > 0.05); and TβRII and TβRIII were significantly downregulated in CAFs compared with NFs, at the mRNA and protein levels (P < 0.05). Exogenous expression of TGF-β1 led to a remarkable decrease in the expression of TβRII and TβRIII in CAFs (P < 0.05). This study provides the first evidence that the loss of TβRII and TβRIII expression in oral epithelium and stroma is a common event in OSCC. The restoration of the expression of TβRII and TβRIII in oral cancerous tissues may represent a novel strategy for the treatment of oral carcinoma

Baltika büroo = The Baltika Offices / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Veerenni 24 asuvast Baltika büroost. Arhitektuur, bürooruumide kujundus: AB Studio 3, Kolm Pluss Üks Arhitektid. Žürii liige Mait Summatavet žürii hinnangust EK arhitektuuri sihtkapitali 2009. a. sisearhitektuuri preemia pälvinud bürooruumidele

78 FR 65387 - Notice of Intent To Seek Approval To Establish an Information Collection

Science.gov (United States)

2013-10-31

... jurisdictions for discovery, innovation and overall knowledge-based prosperity. EPSCoR RII Track-1 projects... improvements in their Research & Development (R&D) capacity and competitiveness. EPSCoR RII Track-1 projects.... They are generally inter- (or multi-)disciplinary and involve effective jurisdictional and regional...

Kas president ikka tõesti eksis? / Hillar Padu

Index Scriptorium Estoniae

Padu, Hillar

2008-01-01

President Toomas Hendrik Ilvese esinemisest Hantõ-Mansiiskis soome-ugri rahvaste maailmakongressil. Autor on seisukohal, et parteiline kriitika president T. H. Ilvese aadressil tunnistab, et demokraatiale pole Eestis ohtu, nagu on mõnel pool mujal Ida-Euroopas. Ungari filosoofi Gaspar Miklos Tamasi artiklist "Tänapäeva Ida-Euroopa". Lisatud karikatuur. Ilmunud ka: Meie Maa : Saarte Suvenädal 11. juuli 2008, lk. 10, pealk.: Kas president Ilves astus ämbrisse?; Meie Maa : Saarte Suvenädal 18. juuli 2008, lk. 10, pealk.: President ei astunud ämbrisse!

Balti Kaitsekolledzhi lõpuaktusel / Lennart Meri

Index Scriptorium Estoniae

Meri, Lennart, 1929-2006

2007-01-01

Tartus 21. juunil 2002. a. peetud kõne Balti Kaitsekolledzhi kolonelide esimese kursuse ja vanemohvitseride kolmanda kursuse lõpuaktusel. Aja väärtuse ja aja kordumatuse täpne tajumine on oluline julgeolekutegur niisugustes väikestes riikides nagu Eesti, Läti ja Leedu või meie lähedased partnerid Kesk- ja Ida-Euroopas. Aeg ei esita küsimusi. Meie ise peame ajale aru andma, kas me oleme teinud kõik, et tõsta oma riigi usaldusväärsust ja kaasa aidata stabiilse julgeoleku tagamisele

150 filmi Odessast Kiievini / Rao Heidmets ; interv. Jaan Ruus

Index Scriptorium Estoniae

Heidmets, Rao, 1956-

2007-01-01

Ukrainas 14. Rahvusvahelise Animafilmide festivali KROK žüriis osalenu ülevaade üritusest, nähtud filmidest, žürii tööst. Eriauhinna sai Riho Undi nukufilm "Vennad Karusüdamed". Peaauhinna sai inglase Luis Cook'i "Õed Pearce'id" ("The Pearce Sisters")

Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement membrane (GBM) nephritis

NARCIS (Netherlands)

Radeke, HH; Janssen-Graalfs, [No Value; Sowa, EN; Chouchakova, N; Skokowa, J; Loscher, F; Schmidt, RE; Heeringa, P; Gessner, JE

2002-01-01

We examined the capacity of mouse glomerular mesangial cells (MC) to express and function through two different low affinity FcgammaRs, the activating FcgammaRIII and the inhibitory FcgammaRII. Immunohistochemistry identified FcgammaRII as the prominent FcgammaR in the kidney, and low levels of

Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides

Science.gov (United States)

2015-01-01

A-kinase anchoring proteins (AKAPs) play an important role in the spatial and temporal regulation of protein kinase A (PKA) by scaffolding critical intracellular signaling complexes. Here we report the design of conformationally constrained peptides that disrupt interactions between PKA and AKAPs in an isoform-selective manner. Peptides derived from the A Kinase Binding (AKB) domain of several AKAPs were chemically modified to contain an all-hydrocarbon staple and target the docking/dimerization domain of PKA-R, thereby occluding AKAP interactions. The peptides are cell-permeable against diverse human cell lines, are highly isoform-selective for PKA-RII, and can effectively inhibit interactions between AKAPs and PKA-RII in intact cells. These peptides can be applied as useful reagents in cell-based studies to selectively disrupt AKAP-localized PKA-RII activity and block AKAP signaling complexes. In summary, the novel hydrocarbon-stapled peptides developed in this study represent a new class of AKAP disruptors to study compartmentalized RII-regulated PKA signaling in cells. PMID:24422448

Rotermanni laudsepatöökoda = Rotermann carpenter's workshop / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Roseni 7 asuva laudsepatöökoja kaasajastamisest. Arhitektid: Andrus Kõresaar, Raivo Kotov (KOKO Arhitektid). Žürii liikme Kalle Komissarovi hinnang kultuurkapitali aastapreemiale esitatud hoonele. Laudsepatöökoda esitati Mies van der Rohe arhitektuuripreemia kandidaadiks ja žürii valis selle oma valiknäitusele

Social inequalities in adult oral health in 40 low- and middle-income countries.

Science.gov (United States)

Bhandari, Bishal; Newton, Jonathon T; Bernabé, Eduardo

2016-10-01

This study evaluated social inequalities in adult oral health across several low- and middle-income countries. We used data from 40 countries that participated in the World Health Surveys. Participants' socio-economic position was assessed using the wealth index. Oral health was assessed using two perceived measures, namely total tooth loss and whether they had any problems with their mouth and/or teeth during the last 12 months (perceived needs). Absolute and relative wealth inequalities in oral health were measured using the slope index of inequality (SII) and the relative index of inequality (RII), respectively, after adjusting for participants' sex, age and education. There were wealth inequalities in total tooth loss and perceived needs in most countries. However, significant monotonic gradients were found in 21 countries for total tooth loss and in 18 countries for perceived needs. Two distinctive patterns of social inequality in oral health were found across countries using the RII and the SII. For total tooth loss, pro-rich inequality was found in 25 countries (significant RII/SII in eight countries) and pro-poor inequality was found in 15 (significant RII/SII in three countries). For perceived needs, pro-poor inequality was found in 26 countries (significant RII/SII in six countries) and pro-rich inequality was found in 14 (significant RII/SII in five countries). The well-documented social gradient in adult oral health favouring the rich was not present in all low- and middle-income countries. Pro-poor inequalities in total tooth loss, and particularly in perceived dental-treatment needs, were observed in some countries. © 2016 FDI World Dental Federation.

Trepp viib linlase Russalka näoni / Teele Tammeorg

Index Scriptorium Estoniae

Tammeorg, Teele

2010-01-01

Tallinn 2011 programmi kuuluvale linnainstallatsioonide festivalile "Lift11" esitati 129 tööd, žürii valis välja 17 kavandit. Pikemalt Argo Peeveri ja Margus Tamme ideest "Face it" ning Tomomi Hayashi ideest jätkata Tallinna Linnahalli treppe. Žürii liikme Endrik Männi arvamus konkursist

Lasva veetorn = Lasva Water Tower / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Lasva veetorni rekonstrueerimisest klavertrepiga kunstigaleriiks-vaatetorniks. Arhitekt, idee autor Veronika Valk, kaasautor Kadri Klementi, klavertrepi teostus: Kalle-Priit Pruuden, trepi elektrooniline heli: Kalle Tikas, infostendid: Peeter Laurits. Žürii liige Kalle Komissarov žürii hinnangust EK arhitektuuri sihtkapitali 2009. a. väikeobjekti preemia pälvinud hoonele

Optimistlik Karlovy Vary / Jaan Ruus

Index Scriptorium Estoniae

Ruus, Jaan, 1938-2017

2007-01-01

42. Karlovy Vary rahvusvahelise filmifestivali auhinnatud filmidest (žürii esimees Peter Bart). Kristallgloobuse sai Islandi-Saksamaa "Katseklaasilinn" (režii Baltasar Kormakur), parimaks režissööriks tunnistati norralane Bard Breien ("Negatiivse mõtlemise kunst"). Austraallase Michael James Rowlandi "Hea õnne teekond" sai žürii eripreemia

GARANȚIILE SPECIALE ÎN CAZUL ARESTĂRII PREVENTIVE ȘI DILIGENȚA AUTORITĂȚILOR PUBLICE PENTRU ASIGURAREA ACESTORA

Directory of Open Access Journals (Sweden)

Vasile SOLTAN

2017-07-01

Full Text Available Obiectul acestui studiu îl reprezintă garanțiile procesuale consacrate de art.5 CEDO în contextul arestului preventiv ca măsură procesuală de constrângere excepțională. În primul rând, trebuie să existe o bănuială rezonabilă că persoana a săvârșit o infracțiune, precum și existența riscurilor lăsării persoanei în libertate. De asemenea, cel reținut trebuie adus de îndată înaintea unui judecător și are dreptul de a fi judecat într-un termen rezonabil sau eliberat în cursul procedurii. Din păcate, exigențele nu sunt întotdeauna respectate, iar în multe situații, fapt constatat de către Curtea Europeană, ju­de­cătorii argumentează aplicarea acestei măsuri limitându-se la parafrazarea motivelor legale pentru arestare, fără a explica cum se aplică speței și fără a examina oportunitatea aplicăriii unor măsuri alternative mai puțin intruzive.SPECIAL GUARANTEES REGARDING PRE-TRIAL DETENTION AND THE DILIGENCE OF PUBLIC AUTHORITIES IN ORDER TO ENSURE THEMThis paper analyzes procedural guarantees regarding pre-trial detention which is intended to be an exceptional measure of last resort, when all other measures are insufficient. Thus, there a several guarantees established by art. 5 of the European Convention of Human Rights (ECHR for the accused people when they face pre-trial detention. The central requirement is a reasonable suspicion that the person has committed a crime and defendants pose a substantial risk of flight, a threat to the safety of the community, victims or witnesses, or a risk of hindering investigations. Also, every one arrested or detained shall be brought promptly before a judge and shall be entitled to trial within a reasonable time or to release pending trial.Unfortunately, the European court has found that judges sometimes relied on unlawful grounds, such as exclusive or primary reliance on the nature of the offences or reasoning was often formulaic and did not engage with

"Sakala" fotograaf pälvis tähelepanu

Index Scriptorium Estoniae

2006-01-01

Eesti Ajalehtede Liidu pressipreemia fotožürii valis välja 2005. a. paremad uudis- ja olemusfotod. Maakonnalehtede parima uudisfoto tiitlile pretendeerivad Elmo Riigi ja Margus Ansu fotod, parima olemusfoto tiitlile Ants Liiguse, Tairo Lutteri ja Sille Annuki fotod. Žürii koosseis. Võitjad kuulutatakse välja 2. märtsil

KURDOVÉ V SÝRII

Directory of Open Access Journals (Sweden)

Michael Murad

2015-06-01

Full Text Available The paper focuses on Syrian Kurds, who compared to Kurds in Iraq and Turkey were out of the spotlight of academic community of researchers. Introduced are Syrian Kurds and their relationship to various regimes that ruled Syria. Complicated relation of Kurds in Syria towards consequences of the Arab Spring is also explained. Relations to the Arab Spring are affected by the historical experience. Kurdish traditional political parties were careful to join the Syrian opposition, but young activists and the diaspora (also diaspora in the Czech Republic was less hesitant to join the opposition movement. Fight with the so called Islamic State has united Kurds in Syria, (and the same happened in Iraq as well however some differences among them remain.

Modulation of type II TGF-β receptor degradation by integrin-linked kinase.

Science.gov (United States)

Vi, Linda; Boo, Stellar; Sayedyahossein, Samar; Singh, Randeep K; McLean, Sarah; Di Guglielmo, Gianni M; Dagnino, Lina

2015-03-01

Cutaneous responses to injury, infection, and tumor formation involve the activation of resident dermal fibroblasts and subsequent transition to myofibroblasts. The key for induction of myofibroblast differentiation is the activation of transforming growth factor-β (TGF-β) receptors and stimulation of integrins and their associated proteins, including integrin-linked kinase (ILK). Cross-talk processes between TGF-β and ILK are crucial for myofibroblast formation, as ILK-deficient dermal fibroblasts exhibit impaired responses to TGF-β receptor stimulation. We now show that ILK associates with type II TGF-β receptors (TβRII) in ligand- and receptor kinase activity-independent manners. In cells with targeted Ilk gene inactivation, cellular levels of TβRII are decreased, through mechanisms that involve enhanced ubiquitination and proteasomal degradation. Partitioning of TGF-β receptors into membrane has been linked to proteasome-dependent receptor degradation. We found that interfering with membrane raft formation in ILK-deficient cells restored TβRII levels and signaling. These observations support a model whereby ILK functions in fibroblasts to direct TβRII away from degradative pathways during their differentiation into myofibroblasts.

Rakvere teatrinoored triumfeerisid taas / Aarne Mäe, Marina Loshtshina

Index Scriptorium Estoniae

Mäe, Aarne, 1967-

2007-01-01

Saaremaal 16. korda peetud miniteatripäevadel sai Grand prix' Rakvere Gümnaasiumi Teatriansambli näitetrupp Pühapäeval kell 4. Žürii otsust kommenteerivad Velvo Väli, Urmas Lennuk ja Vallo Kirs. Publikupreemia, žürii huumoripreemia sai Rakvere Linnanoorte Näitetrupp Daniil Harmsi looga "Juhtumisi". Ka teistest "Jää jumalaga puberteet!" festivali võitjatest

R Factor-Controlled Restriction and Modification of Deoxyribonucleic Acid: Restriction Mutants

Science.gov (United States)

Yoshimori, Robert; Roulland-Dussoix, Daisy; Boyer, Herbert W.

1972-01-01

Restriction mutants of two different R factor-controlled host specificities (RI and RII) were isolated. All of the restriction mutants examined had a normal modification phenotype. No complementation was observed between the RI and RII host specificities. It is concluded that for each host specificity no protein subunit is shared by the restriction endonuclease and modification methylase. PMID:4565538

Rotermanni vana ja uus jahuladu = The Rotermann Old and New Flour Storage / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinna Rotermanni 8 asuvast Rotermanni uuest ja vanast jahulaost, mis pälvis 2009. a. EK arhitektuuri sihtkapitali arhitektuuripreemia linnaruumi tunnetava, uut ja vana tervikuks siduva arhitektuuri eest. Arhitektid: Hanno Grossschmidt, Tomomi Hayashi, Yoko Azukawa (HG Arhitektuur). Büroode üldkujundus: Tarmo Piirmets, Raul Tiitus (OÜ Pink). Žürii liige Kalle Komissarov žürii hinnangust hoonele

Eesti mängufilmid võitsid jälle

Index Scriptorium Estoniae

2007-01-01

Veiko Õunpuu mängufilm "Sügisball" sai 48. Thessaloniki filmifestivalil parima režii auhinna, Ilmar Raagi "Klass" Makedoonias Skopjes 6. Euroopa filmide festivalil CinEdays peaauhinna Kuldne Täht, Kadri Kõusaare "Magnus" Minskis festivalil "Listopad" žürii diplomi ja Marko Raadi "Nuga" Peterburis 10. festivalil "Deboshir Film - Puhtad unelmad" žürii auhinna

Hüvasti, hipodroom! = Farewell, hippodrome / Illimar Truverk

Index Scriptorium Estoniae

Truverk, Illimar, 1967-

2008-01-01

Žürii liige Tallinna Paldiski mnt. 50 kinnistu ja lähiala kutsutud osalejatega arhitektuursest ideevõistlusest, premeeritud töödest, žürii koosseisust. 1.-2. preemia pälvisid QP Arhitektide projekt ja AB Salto projekt. Võitjaks pärast edasitöötamist osutus QP Arhitektide (Tõnu Laigu, Koit Ojaliiv, Mari Rass, Asko Uukado) töö

Ülemaaline ilulugejate 15. võistulausumine

Index Scriptorium Estoniae

2008-01-01

Vabariiklikust etlejate konkursist. 4.-6. klasside arvestuses võitis Grand Prix'i Markkus Pulk, laureaatideks tulid Maria Pihlak, Kenneth Norden ja Laura Elisabeth Konsand. Eripreemiad said Laura Oolup, Maria Zaitseva, žürii aitähi said Sander Aavik ja Liisa Lutter. 7.-9. klasside arvestuses võitis Grand Prix' Anna Talvi, laureaatideks tulid Liisa Saaremäel, Karmen Kozma, Riko Osila. Eripreemiad said Indrek Jõe, Eliise Seedre, žürii aitähi sai Kirke Algma. 10.-12. klasside arvestuses võitis Grand Prix' Doris Tääker, laureaatideks tulid Jörgen Liik, Virgo Ernits ja Ilja Massalov. eripreemiad said Marian Heinat ja Kadri Toomsalu. Kuressaare Gümnaasiumi õpilasžürii preemiad läksid Kenneth Nordenile, Riko Osilale ja Doris Tääkerile

Lower educational level is a predictor of incident type 2 diabetes in European countries: the EPIC-InterAct study.

Science.gov (United States)

Sacerdote, Carlotta; Ricceri, Fulvio; Rolandsson, Olov; Baldi, Ileana; Chirlaque, Maria-Dolores; Feskens, Edith; Bendinelli, Benedetta; Ardanaz, Eva; Arriola, Larraitz; Balkau, Beverley; Bergmann, Manuela; Beulens, Joline W J; Boeing, Heiner; Clavel-Chapelon, Françoise; Crowe, Francesca; de Lauzon-Guillain, Blandine; Forouhi, Nita; Franks, Paul W; Gallo, Valentina; Gonzalez, Carlos; Halkjær, Jytte; Illner, Anne-Kathrin; Kaaks, Rudolf; Key, Timothy; Khaw, Kay-Tee; Navarro, Carmen; Nilsson, Peter M; Dal Ton, Susanne Oksbjerg; Overvad, Kim; Pala, Valeria; Palli, Domenico; Panico, Salvatore; Polidoro, Silvia; Quirós, J Ramón; Romieu, Isabelle; Sánchez, María-José; Slimani, Nadia; Sluijs, Ivonne; Spijkerman, Annemieke; Teucher, Birgit; Tjønneland, Anne; Tumino, Rosario; van der A, Daphne; Vergnaud, Anne-Claire; Wennberg, Patrik; Sharp, Stephen; Langenberg, Claudia; Riboli, Elio; Vineis, Paolo; Wareham, Nicholas

2012-08-01

Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide. In high-income countries, low socioeconomic status seems to be related to a high incidence of T2DM, but very little is known about the intermediate factors of this relationship. Method We performed a case-cohort study in eight Western European countries nested in the EPIC study (n = 340, 234, 3.99 million person-years of follow-up). A random sub-cohort of 16,835 individuals and a total of 12,403 incident cases of T2DM were identified. Crude and multivariate-adjusted hazard ratios (HR) were estimated for each country and pooled across countries using meta-analytical methods. Age-, gender- and country-specific relative indices of inequality (RII) were used as the measure of educational level and RII tertiles were analysed. Compared with participants with a high educational level (RII tertile 1), participants with a low educational level (RII tertile 3) had a higher risk of T2DM [HR: 1.77, 95% confidence interval (CI): 1.69-1.85; P-trend level and risk of T2DM that is only partially explained by variations in BMI.

Identification of a DNA restriction-modification system in Pectobacterium carotovorum strains isolated from Poland.

Science.gov (United States)

Waleron, K; Waleron, M; Osipiuk, J; Podhajska, A J; Lojkowska, E

2006-02-01

Polish isolates of pectinolytic bacteria from the species Pectobacterium carotovorum were screened for the presence of a DNA restriction-modification (R-M) system. Eighty-nine strains of P. carotovorum were isolated from infected potato plants. Sixty-six strains belonged to P. carotovorum ssp. atrosepticum and 23 to P. carotovorum ssp. carotovorum. The presence of restriction enzyme Pca17AI, which is an isoschizomer of EcoRII endonuclease, was observed in all isolates of P. c. atrosepticum but not in P. c. carotovorum. The biochemical properties, PCR amplification, and sequences of the Pca17AI restriction endonuclease and methyltransferase genes were compared with the prototype EcoRII R-M system genes. Only when DNA isolated from cells of P. c. atrosepticum was used as a template, amplification of a 680 bp homologous to the gene coding EcoRII endonuclease. Endonuclease Pca17AI, having a relatively low temperature optimum, was identified. PCR amplification revealed that the nucleotide sequence of genes for EcoRII and Pca17AI R-M are different. Dcm methylation was observed in all strains of Pectobacterium and other Erwinia species tested. The sequence of a DNA fragment coding Dcm methylase in P. carotovorum was different from that of Escherichia coli. Pca17AI is the first psychrophilic isoschizomer of EcoRII endonuclease. The presence of specific Dcm methylation in chromosomal DNA isolated from P. carotovorum is described for the first time. A 680 bp PCR product, unique for P. c. atrosepticum strains, could serve as a molecular marker for detection of these bacteria in environmental samples.

Post-millennial trends of socioeconomic inequalities in chronic illness among adults in Germany.

Science.gov (United States)

Hoebel, Jens; Kuntz, Benjamin; Moor, Irene; Kroll, Lars Eric; Lampert, Thomas

2018-03-27

Time trends in health inequalities have scarcely been studied in Germany as only few national data have been available. In this paper, we explore trends in socioeconomic inequalities in the prevalence of chronic illness using Germany-wide data from four cross-sectional health surveys conducted between 2003 and 2012 (n = 54,197; ages 25-69 years). We thereby expand a prior analysis on post-millennial inequality trends in behavioural risk factors by turning the focus to chronic illness as the outcome measure. The regression-based slope index of inequality (SII) and relative index of inequality (RII) were calculated to estimate the extent of absolute and relative socioeconomic inequalities in chronic illness, respectively. The results for men revealed a significant increase in the extent of socioeconomic inequalities in chronic illness between 2003 and 2012 on both the absolute and relative scales (SII 2003  = 0.06, SII 2012  = 0.17, p-trend = 0.013; RII 2003  = 1.18, RII 2012  = 1.57, p-trend = 0.013). In women, similar increases in socioeconomic inequalities in chronic illness were found (SII 2003  = 0.05, SII 2012  = 0.14, p-trend = 0.022; RII 2003  = 1.14, RII 2012  = 1.40, p-trend = 0.021). Whereas in men this trend was driven by an increasing prevalence of chronic illness in the low socioeconomic group, the trend in women was predominantly the result of a declining prevalence in the high socioeconomic group.

Lateralizing value of unilateral relative ictal immobility in patients with refractory focal seizures--Looking beyond unilateral automatisms.

Science.gov (United States)

Agarwal, Priya; Kaul, Bhavna; Shukla, Garima; Srivastava, Achal; Singh, Mamta Bhushan; Goyal, Vinay; Behari, Madhuri; Suri, Ashish; Gupta, Aditya; Garg, Ajay; Gaikwad, Shailesh; Bal, C S

2015-12-01

Ictal motor phenomena play a crucial role in the localization of seizure focus in the management of refractory focal epilepsy. While the importance of unilateral automatisms is well established, little attention is paid to the contralateral relatively immobile limb. In cases where automatisms mimic clonic or dystonic movements and in the absence of previously well-established signs, unilateral relative ictal immobility (RII) is potentially useful as a lateralizing sign. This study was carried out to examine the lateralizing value of this sign and to define its characteristics among patients of refractory focal epilepsy. VEEGs of 69 consecutive patients of refractory focal epilepsy who had undergone epilepsy surgery at our center over last four years were reviewed and analyzed for the presence of RII. Unilateral RII was defined as a paucity of movement in one limb lasting for at least 10s while the contralateral limb showed purposive or semi-purposive movements (in the absence of tonic or dystonic posturing or clonic movements in the involved limb). The findings were seen in the light of VEEG, radiological and nuclear imaging data, and with post-surgical outcome. Unilateral RII as a lateralizing sign was found in 24 of 69 patients (34.78%), consisting of both temporal and extra temporal epilepsy, with 100% concordance with VEEG and MRI data. All patients demonstrating this sign had a good post-surgical outcome. RII, when well characterized is a frequent and reliable lateralizing sign in patients of refractory focal epilepsy. Copyright © 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Kuldlõvid Louise Bourgeois'le, Bruce Naumanile ja Itaalia paviljonile / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

1999-01-01

Veneetsia 48. rahvusvahelise kunstibiennaali preemiasaajad, premeeritud tööd, korralduskomitee ja žürii koosseis. Kuldlõvid: Louise Bourgeois, Bruce Nauman, Itaalia paviljon (Monica Bonvicini, Bruna Esposito, Luisa Lambri, Paola Pivi, Grazia Toderi ühisprojekt); kolm rahvusvahelist preemiat: Doug Aitken, Cai Gou-Qiang, Shirin Neshat; žürii tõstis esile: Georges Abeagbo, Eija-Liisa Ahtila, Katarzyna Kozura ? (Kozyra), Lee Bul; UNESCO preemia: Ghada Amer

Eesti teater tegi puhta töö / Reet Weidebaum

Index Scriptorium Estoniae

Weidebaum, Reet

2009-01-01

Heidelbergi kaasaegse dramaturgia festivalist "Stückemarkt 2009", kus sel aastal oli külaliseks Eesti oma algupäraste näidenditega - Andrus Kiviräha "Aabitsa kukk", Jim Ashilevi "Portselansuits", Urmas Lennuki "Boob teab". Kommentaare jagavad festivali kunstiline juht ning žürii liige Axel Preuss, tõlkija Irja Grönholm, žürii liikmed Nino Haratischwili, Marion Tiedke ja Andreas Jüttner

Blending topliva v Estonii nikem ne kontrolirujetsja / Andrei Akulistõi

Index Scriptorium Estoniae

Akulistõi, Andrei

2006-01-01

Vastavalt kehtivale seadusandlusele võib tollitsoonis asuvates naftaterminalides valmistada igasuguseid tooteid, isegi kui need oleksid ohtlikud meie keskkonnale ja inimestele, süsteemi toimimine praktikas

Veniv räni / Kate Greene

Index Scriptorium Estoniae

Greene, Kate

2006-01-01

Ränile uusi "trikke" õpetades muudab Illinoisi Urbana-Champaigni ülikooli materjaliethnoloog John Rogers meie arusaamu elektroonika kasutusvõimalustest. Artikkel üldpealkirja all: 10 tulevikutehnoloogiat

Preclinical assessment of viral vectored and protein vaccines targeting the Duffy-binding protein region II of Plasmodium vivax

Directory of Open Access Journals (Sweden)

Simone C de Cassan

2015-07-01

Full Text Available Malaria vaccine development has largely focused on Plasmodium falciparum; however a reawakening to the importance of P. vivax has spurred efforts to develop vaccines against this difficult to treat and at times severe form of relapsing malaria, which constitutes a significant proportion of human malaria cases worldwide. The almost complete dependence of P. vivax red blood cell invasion on the interaction of the P. vivax Duffy-binding protein region II (PvDBP_RII with the human Duffy antigen receptor for chemokines (DARC, makes this antigen an attractive vaccine candidate against blood-stage P. vivax. Here, we generated both preclinical and clinically-compatible adenoviral and poxviral vectored vaccine candidates expressing the Salvador I allele of PvDBP_RII – including human adenovirus serotype 5 (HAdV5, chimpanzee adenovirus serotype 63 (ChAd63 and modified vaccinia virus Ankara (MVA vectors. We report on the antibody and T cell immunogenicity of these vaccines in mice or rabbits, either used alone in a viral vectored prime-boost regime, or in ‘mixed-modality’ adenovirus prime – protein-in-adjuvant boost regimes (using a recombinant protein PvDBP_RII protein antigen formulated in Montanide®ISA720 or Abisco®100 adjuvants. Antibodies induced by these regimes were found to bind to native parasite antigen from P. vivax infected Thai patients and were capable of inhibiting the binding of PvDBP_RII to its receptor DARC using an in vitro binding inhibition assay. In recent years, recombinant ChAd63 and MVA vectors have been quickly translated into human clinical trials for numerous antigens from P. falciparum as well as a growing number of other pathogens. The vectors reported here are immunogenic in small animals, elicit antibodies against PvDBP_RII and have recently entered clinical trials which will provide the first assessment of the safety and immunogenicity of the PvDBP_RII antigen in humans.

Detection of the genetically modified organisms from food products/ Detecţia organismelor modificate genetic din produse alimentare

Directory of Open Access Journals (Sweden)

Curticăpean Manuela

2014-09-01

Full Text Available Încă de la apariţia primelor culturi modificate genetic, oamenii de ştiinţă au avut păreri pro şi contra asupra cultivării si utilizării lor, datorită potenţialelor riscuri pe care le pot avea asupra sănătăţii şi mediului înconjurător. Legislaţia europeană actuală (Directiva 2003/18/CE prevede obligativitatea informării publicului, a monitorizării efectelor pe termen lung, a etichetării şi trasabilităţii în toate stadiile introducerii pe piaţă a OMG. Scopul acestui studiu a fost evaluarea calitativă a produselor alimentare existente pe piaţă, în ceea ce priveşte detecţia prezenţei/ absenţei OMG. În acest sens au fost analizate două tipuri de făină de porumb şi patru tipuri de produse din soia, în perioada 2013. Kit-ul utilizat pentru detecţia prezenţei/absenţei OMG în probele testate, cuprinde etape de izolare ADN, amplificare ADN prin PCR şi electroforeza în gel de agaroză a produşilor amplificaţi şi foloseşte două secvenţe asociate OMG - promotorul 35S şi terminatorul NOS de la Agrobacterium tumefaciens. În urma studiului, au fost pozitive în ceea ce priveşte prezenţa OMG, o probă de mălai extra şi o probă de soia. Rezultatele obţinute ilustrează necesitatea efectuării de analize suplimentare pentru identificarea tipului exact de OMG şi pentru stabilirea cantităţii de OMG (pragul limită impus de legislaţia europeană fiind de 0,9% la nivel de ingredient.

Professor Peep Veski meie meenutustes

Index Scriptorium Estoniae

2014-01-01

Mälestusi Tartu Ülikooli Farmaatsia instituudi juhatajast Peep Veskist jagavad: Eve-Irene Lepist, Urve Paaver, Karin Kogermann, Kristian Semjonov, Jaak Koppel, Kristin Raudsepp, Imre Klebovich, Filiz Hincal, A. Atilla Hincal ja Elmar Arak

Meie esimesed naisfotograafid / Annika Haas

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Haas, Annika, 1974-

2016-01-01

Tallinna fotomuuseumi aastanäitus "Varjust välja. Esimesed naisfotograafid Eestis", kuraatorid Betty Ester-Väljaots, Merili Reinpalu, kunstnik Lilian Juhkam. Eesti naisfotograafide Anna Kuke ja Evi Lembergi eluloolisi andmeid, nende looming

Meie esimesed naisfotograafid / Annika Haas

Index Scriptorium Estoniae

Haas, Annika, 1974-

2015-01-01

Eesti naisfotograafid Hilja Riet ja Lydia Tarem. Fotomuuseumi aastanäitus "Varjust välja. Esimesed naisfotograafid Eestis", kus tutvustatakse Hilja Rieti, Lydia Taremi, Anna Kuke ja Evi Lembergi loomingut. Näituse kuraatorid Betty Ester-Väljaots, Merili Reinpalu

Meie unistuste internet / Roy Strider

Index Scriptorium Estoniae

Strider, Roy, 1974-

2009-01-01

Identiteedimoondamistest ja mainerünnetest virtuaalreaalsuses. Autor leiab, et internet on oma näilises vabaduses muutunud oluliseks võitlustandriks valitsustele, erakondadele ning ettevõtetele ja võib ületada oma kasulikkuse kriitilise piiri. Spinnimiset, mis on info edastamine (ka moonutustega) sellisel moel, et keegi sellest kasu saab.

Educational and wealth inequalities in tobacco use among men and women in 54 low-income and middle-income countries.

Science.gov (United States)

Sreeramareddy, Chandrashekhar T; Harper, Sam; Ernstsen, Linda

2018-01-01

Socioeconomic differentials of tobacco smoking in high-income countries are well described. However, studies to support health policies and place monitoring systems to tackle socioeconomic inequalities in smoking and smokeless tobacco use common in low-and-middle-income countries (LMICs) are seldom reported. We aimed to describe, sex-wise, educational and wealth-related inequalities in tobacco use in LMICs. We analysed Demographic and Health Survey data on tobacco use collected from large nationally representative samples of men and women in 54 LMICs. We estimated the weighted prevalence of any current tobacco use (including smokeless tobacco) in each country for 4 educational groups and 4 wealth groups. We calculated absolute and relative measures of inequality, that is, the slope index of inequality (SII) and relative index of inequality (RII), which take into account the distribution of prevalence across all education and wealth groups and account for population size. We also calculated the aggregate SII and RII for low-income (LIC), lower-middle-income (lMIC) and upper-middle-income (uMIC) countries as per World Bank classification. Male tobacco use was highest in Bangladesh (70.3%) and lowest in Sao Tome (7.4%), whereas female tobacco use was highest in Madagascar (21%) and lowest in Tajikistan (0.22%). Among men, educational inequalities varied widely between countries, but aggregate RII and SII showed an inverse trend by country wealth groups. RII was 3.61 (95% CI 2.83 to 4.61) in LICs, 1.99 (95% CI 1.66 to 2.38) in lMIC and 1.82 (95% CI 1.24 to 2.67) in uMIC. Wealth inequalities among men varied less between countries, but RII and SII showed an inverse pattern where RII was 2.43 (95% CI 2.05 to 2.88) in LICs, 1.84 (95% CI 1.54 to 2.21) in lMICs and 1.67 (95% CI 1.15 to 2.42) in uMICs. For educational inequalities among women, the RII varied much more than SII varied between the countries, and the aggregate RII was 14.49 (95% CI 8.87 to 23.68) in LICs, 3

Parteide sisekultuur kui edu valem? / Ruth Alas

Index Scriptorium Estoniae

Alas, Ruth, 1960-2018

2011-01-01

Tallinna Euroopa kultuuripealinnaks saamisel uuris Estonian Business School (EBS) Eesti organisatsioonide kultuuri. Autori hinnangul oleks huvitav valimiseelses olukorras sama metoodikat rakendada ka meie parteide sisekultuuri hindamisel

CALITATEA COMUNICĂRII ÎN EDUCAŢIA SUPERIOARĂ ÎN CONTEXTUL INTEGRĂRII EUROPENE

Directory of Open Access Journals (Sweden)

Lidia Cristea

2007-05-01

Full Text Available The present paper propose to state a couple of orientative suggestions within the domain of the furthereducation having as a source the discussions within the frame of the Conference in Berlin from September 2003that stipulates the quality of the educational process regarding the assurance of the European FurtherEducation.The transmission of the informational flow within the further educational system may became a naturalprocess of regionalising and of globalisation projected into the normative regulations elaborated and of thestipulation of some well-defined standards.As Pierre Guirond stated in his paper "Language et théorie de la communications", thecommunications is "the transfer of the information by means of messages", as well as the present paper analysedthe barriers that must be surpassed within the process of communication between the professor and the studentin the frame of the Romanian further education suggesting modalities of surpassing them.

CALITATEA COMUNICĂRII ÎN EDUCAŢIA SUPERIOARĂ ÎN CONTEXTUL INTEGRĂRII EUROPENE

Directory of Open Access Journals (Sweden)

Lidia CRISTEA

2007-06-01

Full Text Available The present paper propose to state a couple of orientativesuggestions within the domain of the further education having as a source thediscussions within the frame of the Conference in Berlin from September2003 that stipulates the quality of the educational process regarding theassurance of the European Further Education.The transmission of the informational flow within the furthereducational system may became a natural process of regionalising and ofglobalisation projected into the normative regulations elaborated and of thestipulation of some well-defined standards.As Pierre Guirond stated in his paper "Language et théorie de lacommunications", the communications is "the transfer of the information bymeans of messages", as well as the present paper analysed the barriers thatmust be surpassed within the process of communication between theprofessor and the student in the frame of the Romanian further educationsuggesting modalities of surpassing them.

Andestus, puhastumine ja kirgastus / Heie Treier

Index Scriptorium Estoniae

Treier, Heie, 1963-

2011-01-01

Žürii liige kommunismiohvrite memoriaali asukoha ja ideekavandi võistlusest. 66 võistlustööd on väljas näitusel Eesti Arhitektuurimuuseumis 16.11.-04.12.2011. 1.-2. kohta jagavad ideekavandid "Vest" (autorid Armin Valter, Joel Kopli) ja "Mälutulbad" (autor Koit Ojaliiv). Loetletud eripreemia saanud neli tööd, äramärgitud neli tööd, žürii koosseis

Me saame hakkama! / Toomas Hendrik Ilves

Index Scriptorium Estoniae

Ilves, Toomas Hendrik, 1953-

2009-01-01

Vabariigi Presidendi tervitus 2008/2009. aastavahetusel. Ilmunud ka: Postimees 3. jaan. 2009, lk. 3, pealk.: President Toomas Hendrik Ilvese uusaastatervitus; Eesti Päevaleht 3. jaan. 2009, lk. 3, pealk.: Sajandi keerulisim aasta. Vt. samas: Muutunud aeg. Väljavõte presidendi uusaastakõnest 2007. aasta 31. detsembril; Oma Saar 3. jaan. 2009, lk. 5, pealk.: Armas rahvas!; Pärnu Postimees 3. jaan. 2009, lk. 5, pealk.: Vabariigi presidendi aastavahetuse tervitus; Võrumaa Teataja 3. jaan. 2009, lk. 2, pealk.: Vabariigi presidendi tervitus aastavahetusel 2008/2009; Virumaa Teataja 3. jaan. 2009, lk. 11, pealk.: Homne on meie teha; Järva Teataja 3. jaan. 2009, lk. 2, pealk.: Me tuleme toime; Hiiu Leht : Nädalalõpp 9. jaan. 2009, lk. 6, pealk.: Armas rahvas!; Meie Maa 3. jaan. 2009, lk. 2 (tsitaat kõnest); Vaba Eesti Sõna 8. jaan. 2009, lk. 3, pealk.: Vabariigi Presidendi tervitus aastavahetusel; Eesti Päevaleht (Stockholm) 14. jaan. 2009, lk. 1, pealk.: Toomas Hendrik Ilves: Jäägem raskuste kiuste ausaks; Eesti Elu 9. jaan. 2009, lk. 2, pealk.: Vabariigi Presidendi tervitus 2008/2009. aastavahetusel; Meie Kodu 21. jaan. 2009, lk. 1, pealk.: Vabariigi Presidendi tervitus 2008/2009. aastavahetusel; Eesti Hääl 24. jaan. 2009, lk. 1, pealk.: EV Presidendi kõne

Tänavused mõjukamad valimised / Kalev Kask

Index Scriptorium Estoniae

Kask, Kalev

2004-01-01

Ilmunud ka: Meie Maa, 2. nov. 2004, lk. 4. Ameerika Ühendriikides toimuvatest presidendivalimistest, kus otsustavaks kujuneb kahe kandidaadi, George Walker Bushi ja John Forbes Kerry, vaheline heitlus

Kuues Pärnu rahvusvaheline koorifestival stardib

Index Scriptorium Estoniae

2006-01-01

Pärnu rahvusvahelise koorifestivali avakontserdist 25. mail, noortekooride galakontserdist "Meie tuleme!" 26. mail ja rahvalaulukonkursist "Õhtu pealt on ilus laulda kas'ke" 27. mail Pärnu Kontserdimajas

Harju maakohus saab Herman Simmi "nimelise" istungitesaali / Holger Roonemaa ; intervjueerinud Jan Jõgis-Laats ; kommenteerinud Andrus Ansip

Index Scriptorium Estoniae

Roonemaa, Holger

2009-01-01

Tingimustest turvaalale, kus töödeldakse riigisaladusi ja Harju maakohtu istungisaali vastavusest nendele Herman Simmi kohtuasja arutamiseks. Vt. samas lühiinterv.: Ansip: Simm pole meie James Bond

Eesti põllumajanduspoliitika ja WTO leping ei vasta Eesti rahvuslikele huvidele / Janno Reiljan

Index Scriptorium Estoniae

Reiljan, Janno, 1951-2018

2001-01-01

Eesti liitus Maailma Kaubandusorganisatsiooniga (WTO) endale ebasoodsatel tingimustel, mis ei võimalda meie põllumajandustoodetel välisturul konkureerida. Tabel: Eesti väliskaubandus põllumajandussaadustega. Autor: ERL. Parlamendisaadik

Verba volant, scripta manent / Milvi Tedremaa

Index Scriptorium Estoniae

Tedremaa, Milvi, 1937-2012

1999-01-01

Rets. rmt.: Meie õppisime raamatukogundust Tartu Ülikoolis / koost. Maare Kümnik, Kaja Noodla. Tartu, 1998. Vastukaja: Peep, Laine. Mitte ainult Milvi Tedremaale // Raamatukogu (1999) nr. 4, lk. 44

Milleks põllumajandusmaastiku elurikkus? / Eneli Viik, Iiri Raa, Ere Ploomipuu, Katrin Vask

Index Scriptorium Estoniae

2012-01-01

Elurikkus on meie maakeral leiduva kogu elusa looduse mitmekesisus, mida võib eristada kolmel tasandil: geneetiline tasand, liikide tasand, koosluste mitmekesisuse tasand. Kuidas säilitada elurikkust põllumajandusmaastikul

Paide gümnaasiumi spordihoone konkurss = Paide Gymnasium Sports Hall Competition / Tiit Trummal

Index Scriptorium Estoniae

Trummal, Tiit, 1954-

2006-01-01

Žürii liige konkursist, võidutöödest. Žürii koosseis. Konkursi tulemused: I preemia - Karli Luik, Ralf Lõoke, Maarja Kask, töö "Täheke"; II - Ott Kadarik, Villem Tomiste, Mihkel Tüür, töö "Unioon"; III - Koit Ojaliiv, Juhan Rohtla, kaasautor Tõnu Laigu, töö "Kivi"; ostupreemia - Lauri Saar, Tõnu Laanemäe, Indrek Järve, Jaak-Adam Looveer (PAIK Arhitektid), töö "Sensei"

Cui bono? / Kaivo Thomson

Index Scriptorium Estoniae

Thomson, Kaivo, 1956-

2014-01-01

Meie õpilased ei oska teadmisi väljaspool klassi- ja eksamiruumi alati rakendada. Kas haridusreform suudab haridussüsteemis vajalikke muudatusi esile kutsuda? Inimese kognitiivsest stiilist lähtuvast õpetamisest

Linnud näitavad maailma ohte ja võimalusi

Index Scriptorium Estoniae

2013-01-01

Kanadas Ottawas peetud maailma suurima looduskaitseorganisatsioonide võrgustiku Bird Life maailmakongressil esitletud raportist "State of the world's birds: indicators for our changing world ("Maailma lindude seisund: meie muutuva maailma indikaatorid")

Soome laht Eesti sisemereks / Igor Gräzin

Index Scriptorium Estoniae

Gräzin, Igor, 1952-

2008-01-01

Venemaa otsus suurendada naftavedu läbi Soome lahe ähvardab katastroofidega siinset piirkonda. Eesti merepiiri nihutamisega Soome lahe keskjoonele saab Eesti maksustada läbi meie territooriumi kulgeva transiidi

Kõigepealt tuleb moraal / Bernd Ulrich

Index Scriptorium Estoniae

Ulrich, Bernd

2007-01-01

Autor selgitab, et kliimamuutused asetavad inimkonna enneolematusse olukorda, mis tingib meie eluviisi ja majanduse radikaalse muutuse. Keskkonnapoliitikas osutuvad idealistid realistideks, kes on juba ammu teinud ettepanekuid kliimamuutuste vältimiseks

Abielu, perekonna ja õnnistuse tähendus / Chung Hwan Kwak

Index Scriptorium Estoniae

Kwak, Chung Hwan

2002-01-01

Ettekanne Rahvusvahelise ja Relgioonidevahelise Föderatsiooni Maailmarahu eest (IIFWP) Tallinnas peetud seminaril "Riigi uuendamine: perekondi tugevdavate, meie noori kasvatavate ja ühiskonda taasehitavate printsiipide ja praktikate uurimine" : lühendatult

Soul / Randy Becker, Bill Evans, Evelin Samuel ; interv. Sven Sapelson

Index Scriptorium Estoniae

Becker, Randy

2007-01-01

The Soulbop Bandi rajajad Randy Becker ja Bill Evans ning meie Evelin Samuel gospeli ja rhytmblues'i juurtega soulist. Lk. 72-73 Inessa Josingu ja Ande Kaalepi souliteemaline fotolavastusega ruumikujundus

Tartumurdelise kirjanduse ettejõudmine ; Parandatud kirikukeele ja rahvaraamatute poole / Gustav Suits

Index Scriptorium Estoniae

Suits, Gustav, 1883-1956

1999-01-01

Varem ilmunud: Suits, Gustav. Eesti kirjanduslugu I. Lund : Eesti Kirjanike Kooperatiiv, 1953. Lõunaeestikeelne "Meie Issanda Jesusse Kristusse Wastne Testament" (Riia, 1686). Eeltöödest põhjaeestikeelse piibli väljaandmiseks

Welcome to Denmark! / Eiki Nestor

Index Scriptorium Estoniae

Nestor, Eiki, 1953-

2005-01-01

Kuigi meie poliitikud toovad eeskujuks Taani paindliku tööturu, viib Eesti valitsuse kava autori sõnul pigem Bangladeshi kui Taani suunas. Autor selgitab, mis meid Taanist selles valdkonnas eristab

Pime eurousk

Index Scriptorium Estoniae

2002-01-01

Ülevaade ajalehes Wall Street Journal Eestile pühendatud artiklist "Ohtlikult pime usk Euroopa Liidusse", kus kummastatakse meie entusiasmi ja naiivsust pürgimisel järjekordsesse rahvaste ühendusse

Quantitative assessment of human-induced impacts based on net primary productivity in Guangzhou, China.

Science.gov (United States)

Wu, Yanyan; Wu, Zhifeng

2018-02-08

Urban expansion and land cover change driven primarily by human activities have significant influences on the urban eco-environment, and together with climate change jointly alter net primary productivity (NPP). However, at the spatiotemporal scale, there has been limited quantitative analysis of the impacts of human activities independent of climate change on NPP. We chose Guangzhou city as a study area to analyze the impacts of human activities on NPP, as well as the spatiotemporal variations of those impacts within three segments, using a relative impact index (RII) based on potential NPP (NPP p ), actual NPP (NPP act ), and NPP appropriation due to land use/land cover change (NPP lulc ). The spatial patterns and dynamics of NPP act and NPP lulc were evaluated and the impacts of human activities on NPP during the process of urban sprawl were quantitatively analyzed and assessed using the RII. The results showed that NPP act and NPP lulc in the study area had clear spatial heterogeneity, between 2001 and 2013 there was a declining trend in NPP act while an increasing trend occurred in NPP lulc , and those trends were especially significant in the 10-40-km segment. The results also revealed that more than 91.0% of pixels in whole study region had positive RII values, while the lowest average RII values were found in the > 40-km segment (39.03%), indicating that human activities were not the main cause for the change in NPP there; meanwhile, the average RII was greater than 65.0% in the other two, suggesting that they were subjected to severe anthropogenic disturbances. The RII values in all three segments of the study area increased, indicating an increasing human interference. The 10-40-km buffer zone had the largest slope value (0.5665), suggesting that this segment was closely associated with growing human disturbances. Particularly noteworthy is the fact that the > 40-km segment had a large slope value (0.3323) and required more conservation efforts. Based

Teine katse: Tallinna Muusikakeskooli, Tallinna Balletikooli ja G. Otsa nimelise Tallinna Muusikakooli uus hoone / Tomomi Hayashi

Index Scriptorium Estoniae

Hayashi, Tomomi, 1971-

2011-01-01

Žürii liige koolide ühishoone rahvusvahelisest arhitektuurivõistlusest, žürii kommentaarid ja ettepanekud premeeritud kolmele tööle. 1. preemia pälvis töö "Vaikuse aed" (Thomas Pucher jt. / Atelier Thomas Pucher ZT GmbH, Austria), 2. preemia töö "Octopus" (Andrus Mark, Emil Urbel, Aleksandr Zverev / AB Emil Urbel), 3. koha töö "Pausid ja poosid" (Jaan Tiidemann, Tõnis Arjus, Eve Komp / Ninja Stuudio). Jarmo Kauge intervjuu Thomas Pucheriga

Does personality predict mortality? Results from the GAZEL French prospective cohort study.

Science.gov (United States)

Nabi, Hermann; Kivimäki, Mika; Zins, Marie; Elovainio, Marko; Consoli, Silla M; Cordier, Sylvaine; Ducimetière, Pierre; Goldberg, Marcel; Singh-Manoux, Archana

2008-04-01

Majority of studies on personality and physical health have focused on one or two isolated personality traits. We aim to test the independent association of 10 personality traits, from three major conceptual models, with all-cause and cause-specific mortality in the French GAZEL cohort. A total of 14,445 participants, aged 39-54 in 1993, completed the personality questionnaires composed of the Bortner Type-A scale, the Buss-Durkee Hostility Inventory (for total, neurotic and reactive hostility) and the Grossarth-Maticek-Eysenck Personality Stress Inventory that assesses six personality types [cancer-prone, coronary heart disease (CHD)-prone, ambivalent, healthy, rational, anti-social]. The association between personality traits and mortality, during a mean follow-up of 12.7 years, was assessed using the Relative Index of Inequality (RII) in Cox regression. In models adjusted for age, sex, marital status and education, all-cause and cause-specific mortality were predicted by 'total hostility', its 'neurotic hostility' component as well as by 'CHD-prone', 'ambivalent' 'antisocial', and 'healthy' personality types. After mutually adjusting personality traits for each other, only high 'neurotic hostility' remained a robust predictor of excess mortality from all causes [RII = 2.62; 95% confidence interval (CI) = 1.68-4.09] and external causes (RII = 3.24; 95% CI = 1.03-10.18). 'CHD-prone' (RII = 2.23; 95% CI = 0.72-6.95) and 'anti-social' (RII = 2.13; 95% CI 0.61-6.58) personality types were associated with cardiovascular mortality and with mortality from external causes, respectively, but CIs were wider. Adjustment for potential behavioural mediators had only a modest effect on these associations. Neurotic hostility, CHD-prone personality and anti-social personality were all predictive of mortality outcomes. Further research is required to determine the precise mechanisms that contribute to these associations.

Fond ootab võistlusele laste omaloomingut

Index Scriptorium Estoniae

2005-01-01

Avatud Eesti Fond kuulutab Euroopa kodanikuhariduse aasta puhul välja laste ja noorte omaloominguvõistluse, kuhu oodatakse teemal "Meie muudame maailma" lasteaia- ja algklassilaste joonistusi ja V-XII klassi õpilaste esseid

Irina Hakamada : "Sex v bolshoi politike" - eto samoutshitel / Irina Hakamada ; interv. Jelena Majakova

Index Scriptorium Estoniae

Hakamada, Irina

2006-01-01

Venemaa tuntuim naispoliitik Irina Hakamada avas regioonidevahelise sotsiaalse solidaarsuse fondi Meie Valik ning liitus Venemaa ekspeaministri ja demokraatide 2008. a. tõenäolise presidendikandidaadi Mihhail Kasjanovi juhitava ühiskondlik-poliitilise liikumisega

Kas lahja alkohol tagasi kioskitesse? / Meelis Atonen, Ignar Fjuk

Index Scriptorium Estoniae

Atonen, Meelis, 1966-

2002-01-01

Ilmunud ka: Meie Maa 2. oktoober lk. 2 (ainult Ignar Fjuki tekst), Vali Uudised 9. oktoober lk. 9. Alkoholiseaduse muutmise arutelust Riigikogus. Alkoholi kättesaadavuse piiramisest. Riigi alkoholipoliitikast. Autor: Reformierakond. Parlamendisaadik

Endogenous protection derived from activin A/Smads transduction loop stimulated via ischemic injury in PC12 cells.

Science.gov (United States)

Mang, Jing; Mei, Chun-Li; Wang, Jiao-Qi; Li, Zong-Shu; Chu, Ting-Ting; He, Jin-Ting; Xu, Zhong-Xin

2013-10-17

Activin A (ActA), a member of transforming growth factor-beta (TGF-b) super- family, affects many cellular processes, including ischemic stroke. Though the neuroprotective effects of exogenous ActA on oxygen-glucose deprivation (OGD) injury have already been reported by us, the endogenous role of ActA remains poorly understood. To further define the role and mechanism of endogenous ActA and its signaling in response to acute ischemic damage, we used an OGD model in PC12 cells to simulate ischemic injury on neurons in vitro. Cells were pre-treated by monoclonal antibody against activin receptor type IIA (ActRII-Ab). We found that ActRII-Ab augments ischemic injury in PC12 cells. Further, the extracellular secretion of ActA as well as phosphorylation of smad3 in PC12 cells was also up-regulated by OGD, but suppressed by ActRII-Ab. Taken together, our results show that ActRII-Ab may augment ischemic injury via blocking of transmembrane signal transduction of ActA, which confirmed the existence of endogenous neuroprotective effects derived from the ActA/Smads pathway. ActRIIA plays an important role in transferring neuronal protective signals inside. It is highly possible that ActA transmembrance signaling is a part of the positive feed-back loop for extracellular ActA secretion.

Endogenous Protection Derived from Activin A/Smads Transduction Loop Stimulated via Ischemic Injury in PC12 Cells

Directory of Open Access Journals (Sweden)

Zhong-Xin Xu

2013-10-01

Full Text Available Activin A (ActA, a member of transforming growth factor-beta (TGF-b super- family, affects many cellular processes, including ischemic stroke. Though the neuroprotective effects of exogenous ActA on oxygen-glucose deprivation (OGD injury have already been reported by us, the endogenous role of ActA remains poorly understood. To further define the role and mechanism of endogenous ActA and its signaling in response to acute ischemic damage, we used an OGD model in PC12 cells to simulate ischemic injury on neurons in vitro. Cells were pre-treated by monoclonal antibody against activin receptor type IIA (ActRII-Ab. We found that ActRII-Ab augments ischemic injury in PC12 cells. Further, the extracellular secretion of ActA as well as phosphorylation of smad3 in PC12 cells was also up-regulated by OGD, but suppressed by ActRII-Ab. Taken together, our results show that ActRII-Ab may augment ischemic injury via blocking of transmembrane signal transduction of ActA, which confirmed the existence of endogenous neuroprotective effects derived from the ActA/Smads pathway. ActRIIA plays an important role in transferring neuronal protective signals inside. It is highly possible that ActA transmembrance signaling is a part of the positive feed-back loop for extracellular ActA secretion.

Use of Sunflower Meal as a Substitute for Cottonseed Meal in Rations of Growing Lambs

International Nuclear Information System (INIS)

Saleh, S.A.; EI-Fouly, H.A.

2008-01-01

Eighteen growing male lambs with an average of 3 months old were randomly divided into three equal groups. Animals of each group were kept in separate shaded pen and fed one of the three tested rations as follows: 1st group fed ration one (RI): (CFM) concentrate feed mixture contained 30% cottonseed meal (CSM) + 0.00 sunflower meal (SFM). 2nd group fed ration two (RII): CFM contained 15% CSM + 15% SFM. 3rd group fed ration three (RIll): CFM contained 00.0% CSM + 30% SFM. Wheat straw was offered to the 3 experiment groups ad libitum. Lambs were weighed at the beginning of the experimental period then at two weeks intervals. At the end of the experimental period, four animals from each group were used to evaluate the nutrients digestibility and nutritive value of the experimental rations. Blood samples were taken each three weeks before feeding animals. The present study showed that lambs fed RII and RIll had significantly higher CP and EE digestibility values compared to those fed RI. % Nitrogen balance was currently higher for RIll than RI and RII. No significant differences among the tested blood serum parameters for the experimental lambs except for total protein, AST, triglycerides and cholesterol values. Average daily weight gain (ADG) and feed efficiency were better for RII and RIll than RI

An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy

Science.gov (United States)

Minetti, Giulia C.; Sheppard, KellyAnn; Ibebunjo, Chikwendu; Feige, Jerome N.; Hartmann, Steffen; Brachat, Sophie; Rivet, Helene; Koelbing, Claudia; Morvan, Frederic; Hatakeyama, Shinji

2014-01-01

The myostatin/activin type II receptor (ActRII) pathway has been identified to be critical in regulating skeletal muscle size. Several other ligands, including GDF11 and the activins, signal through this pathway, suggesting that the ActRII receptors are major regulatory nodes in the regulation of muscle mass. We have developed a novel, human anti-ActRII antibody (bimagrumab, or BYM338) to prevent binding of ligands to the receptors and thus inhibit downstream signaling. BYM338 enhances differentiation of primary human skeletal myoblasts and counteracts the inhibition of differentiation induced by myostatin or activin A. BYM338 prevents myostatin- or activin A-induced atrophy through inhibition of Smad2/3 phosphorylation, thus sparing the myosin heavy chain from degradation. BYM338 dramatically increases skeletal muscle mass in mice, beyond sole inhibition of myostatin, detected by comparing the antibody with a myostatin inhibitor. A mouse version of the antibody induces enhanced muscle hypertrophy in myostatin mutant mice, further confirming a beneficial effect on muscle growth beyond myostatin inhibition alone through blockade of ActRII ligands. BYM338 protects muscles from glucocorticoid-induced atrophy and weakness via prevention of muscle and tetanic force losses. These data highlight the compelling therapeutic potential of BYM338 for the treatment of skeletal muscle atrophy and weakness in multiple settings. PMID:24298022

I eto snezhnaja koroleva?

Index Scriptorium Estoniae

2005-01-01

Taani kunstniku Erik Bagge tööde näitusest "Hans Christian Andersen meie ajal" Tallinna Kultuuritehases Polymer. Kunstniku tööd on inspireeritud Anderseni muinasjuttudest, viikingite ornamentidest ja kaasaja elust

Kes kardab poeete? / Giuseppe Provenzano ; tõlk. Katrin Tombak

Index Scriptorium Estoniae

Provenzano, Giuseppe

2008-01-01

Tallinna Harjumäele rajatavast Vabaduse monumendist, ummiku äärele jõudnud avalikust diskussioonist, monumendi tähendusest. Õnnestunud monument peab esmajoones puudutama meie hinge ja tal ei tohiks puududa ilu

Kolmas "Matrix" põrutab kuulipildujaga / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2003-01-01

Andy ja Larry Wachowski ulmefilmide triloogia 3. osa "Matrix : Revolutsioon" ("The Marix Revolutions") jõuab 5. novembril kell 16 meie aja järgi esilinastuseni korraga paljudes riikides, sealhulgas MPDE vahendusel ka Eestis

Arbeit macht frei / Eerik-Niiles Kross

Index Scriptorium Estoniae

Kross, Eerik-Niiles, 1967-

2006-01-01

Autor toob paralleeli Teise maailmasõja järgsest Saksamaast, kui teravnes debatt endistele natsidele riigis domineeriva positsiooni andmise üle, ning esitab vastuargumente meie lähiajaloo mõtestamise debatis esitatud seisukohtadele

Külamehe kelder hoiab nahkhiire elus / Matti Masing

Index Scriptorium Estoniae

Masing, Matti, 1953-

2004-01-01

Vt. ka Meie Maa 27. nov., Koit : Nädal 29. nov., Lääne Elu 4. dets. Erinevate pealk. all. Nahkhiirte talvitumisest keldrites, mida teha nahkhiirte kaitseks ning nahkhiirte uurimisest ja kaitsest Euroopas

Mida täiskasvanute oskuste uuring meile näitas? / Aune Valk, Vivika Halapuu

Index Scriptorium Estoniae

Valk, Aune, 1972-

2013-01-01

Avalikustati rahvusvahelise täiskasvanute oskuste uuringu PIAAC tulemused, mis näitas meie 16-65-aastaste inimeste peamiste infotöötlusoskuste taset nii riigi sees kui ka võrdluses teiste riikidega

Ikka veel osaliselt väge täis / Veiko Märka

Index Scriptorium Estoniae

Märka, Veiko, 1964-

2009-01-01

Rakvere teatri lavastustest : Eric-Emmanuel Schmitt "Kooselu väikesed kuriteod", lavastaja Erki Aule; Neil Simon "Meie, mehed", lavastaja Toomas Suuman ja Ernest Hemingway "Ja päike tõused", lavastaja Jaaniks Juhanson

Kuusalu vallavanemana jätkab Herko Sunts / Ülle Tamm

Index Scriptorium Estoniae

Tamm, Ülle, 1962-

2005-01-01

Kuusalu vallavolikogu valis 11 häälega vallavanemaks seni sama ametit pidanud Herko Suntsi. Valimisliitude Ühiselt Edasi ja Meie Kodu koalitsioonileping jäi sõlmimata. Vt. samas intervjuud Herko Suntsiga

Lups lugema! / Maaja Mänd

Index Scriptorium Estoniae

Mänd, Maaja

2006-01-01

Kirjastuses "Ilo "on välja antud õppematerjalid : "Lups lugema I,II ; "Tähevihik" ; "Sõnad ja poldid" ; "Asjad meie kodus " ; "Tähepusle" ; "Numbripusle" ; "Mänge siit ja sealt"; Kaheksakand Õnnetäht

PROBLEMATICA DEFINIRII CONCEPTULUI DE CARIERĂ ŞI DE PROIECTARE A CARIEREI

Directory of Open Access Journals (Sweden)

Viorica CHETRARI

2015-12-01

Full Text Available Proiectarea carierei este un concept complex. Articolul traversează istoria modelării conceptelor de carieră şi de proiectare a carierei şi a teoriilor privind cariera în scopul delimitării conceptuale a termenilor sus-numiţi.THE ISSUE OF DEFINING THE CONCEPT OF CAREER AND CAREER PLANNINGCareer planning is a complex concept. The article discusses the history of career and career planning notions and theories, trying to define the concepts mentioned above.

Ristikultuuri äratajad / Heinz Valk, Eerik Kõuts, Sirje Endre

Index Scriptorium Estoniae

Valk, Heinz, 1936-

1998-01-01

Intervjuu raamatu "Rist ja raud" autorite Heinz Valgu ja Eerik Kõutsiga meie kalmistukultuurist ja vanadest sepistest ning raamatu väljaandja Sirje Endrega; raamatu fotode autor on Tiit Veermäe, kujundaja Andres Tali

14. september - kas lõppjaam või vahepeatus? / Imre Annus

Index Scriptorium Estoniae

Annus, Imre, 1971-

2003-01-01

Imre Annus Eesti Maa Põlisrahvaste Kesktoimkonnast võrdleb eestlast ja Eesti põlisrahvast ning küsib, kes andis meie tänastele valitsejatele õiguse kaubelda selle maa põlisrahva sõltumatuse ja iseseisvusega

Ristipoja mälestusi / Reino Sepp

Index Scriptorium Estoniae

Sepp, Reino

2005-01-01

Reino Sepa mälestusi Johannes Aavikust. Katkendid on võetud tema varem ilmunud artiklist "Mälestusi ja mõteid Johannes Aavikust", mis ilmus 1991. aastal ajalehe Meie Maa väljaandes "Minu Saaremaa"

Varakambri lahtine värav / Katrin Kaugver

Index Scriptorium Estoniae

Kaugver, Katrin, 1950-

2008-01-01

Uppsalas toimunud CERL-i (Consortium of European Research Libraries) vanaraamatu seminar "Käsikiri, trükis ja internet", kus TLÜ professor Tiiu Reimo andis ülevaate meie raamatukogude ja arhiivide vanatrükiste kogudest

R. Rathke kabinetklaveri restaureerimine-konserveerimine / Merle Ambre

Index Scriptorium Estoniae

Ambre, Merle

2011-01-01

Antakse ülevaade 231 aastat kestnud klaveriehitusest Eestis, R. Rathke osast meie klaveritööstuse arengus ja pikemalt klaverimeistrite tegevusest Tartus ning Peterburis. Praktiliseks tööks oli kabinetklaveri restaureerimine ja konserveerimine

Säärane mulk, ehk sada vakka etteheiteid / Avo Üprus

Index Scriptorium Estoniae

Üprus, Avo, 1954-

2004-01-01

Ilmunud ka: Hiiumaa, 24. juuli 2004, lk. 2; Võrumaa Teataja, 24. juuli 2004, lk. 2; Vooremaa, 24. juuli 2004, lk. 2; Meie Maa, 23. juuli 2004, lk. 2; Järva Teataja, 27. juuli 2004, lk. 4; Lääne Elu, 27. juuli 2004, lk. 2; Koit, 27. juuli 2004, lk. 6; Pärnu Postimees, 28. juuli 2004, lk. 15; Virumaa Teataja, 30. juuli 2004, lk. 7; Vali Uudised, 30. juuli 2004, lk. 2; Põhjarannik, 30. juuli 2004, lk. 2; Severnoje Poberezhje, 30. juuli 2004, lk. 2; Hiiu Leht, 3. aug. 2004, lk. 2; Sakala, 3. aug. 2004, lk. 2; Valgamaalane, 12. aug. 2004, lk. 2. Vastuseks Helir-Valdor Seederi art. 17. juuli ajal. Meie Maa. Uus poliitika tähendab üldinimlike väärtuste taasväärtustamise kaudu pidevalt uuenevat riiki.

Expression and autoregulation of transforming growth factor beta receptor mRNA in small-cell lung cancer cell lines

DEFF Research Database (Denmark)

Nørgaard, P; Spang-Thomsen, M; Poulsen, H S

1996-01-01

In small-cell lung cancer cell lines resistance to growth inhibition by transforming growth factor (TGF)-beta 1, was previously shown to correlate with lack of TGF-beta receptor I (RI) and II (RII) proteins. To further investigate the role of these receptors, the expression of mRNA for RI, RII...... and beta-glycan (RIII) was examined. The results showed that loss of RII mRNA correlated with TGF-beta 1 resistance. In contrast, RI-and beta-glycan mRNA was expressed by all cell lines, including those lacking expression of these proteins. According to Southern blot analysis, the loss of type II m......RNA was not due to gross structural changes in the gene. The effect of TGF-beta 1 on expression of TGF-beta receptor mRNA (receptor autoregulation) was examined by quantitative Northern blotting in four cell lines with different expression of TGF-beta receptor proteins. In two cell lines expressing all three TGF...

Asigurarea competitivității inovațiilor și sustenabilității economice a Israelului

Directory of Open Access Journals (Sweden)

Hani ABURABIA

2018-03-01

Full Text Available Lumea se confruntă cu o schimbare economică și de mediu majoră. Schimbările clima¬tice, problemele demografice, urbanizarea globală implică în ultimele decenii provocări și constrângeri evidente. Organismele internaționale sunt îngrijorate de creșterea populației, inclusiv a celei urbane, până la peste 7 miliarde, din care circa 60% locuiește în mediul ur¬ban. Peste 76% din consumul de energie în Europa revine aceluiași mediu. Sunt necesare măsuri eficiente pentru a reduce emisiunile de gaze și substanțe nocive întru a evita cele mai grave scenarii care pot surveni. Scopul cercetării constă în investigarea stării reale din sectorul economic vizând dezvoltarea durabilă și experiența de promovare a dezvoltării economice cu protecția oicumena.

Seadust järgida on igaühele kasulik / Margi Ein

Index Scriptorium Estoniae

Ein, Margi, 1950-

2005-01-01

Majanduslike huvide deklaratsioonide esitamisest. Sama ka Nädaline 16. aprill 2005, lk. 2 ; Meie Maa 19. aprill 2005, lk. 9 ; Põhjarannik 19. aprill 2005, lk. 2 artikli pealkiri kujul: Ametiisikud peavad esitama majanduslike huvide deklaratsiooni

Rahvas palkab 101 töötajat / Tarmo Pikner

Index Scriptorium Estoniae

Pikner, Tarmo

2003-01-01

Saare Maavalitsuse arengu- ja planeeringu osakonna juhataja Tarmo Pikneri sõnul on piirkondlike erinevustega arvestamine meie riigi seadusandluses enam kui puudulik. Igal Riigikogu liikmel peaks olema ette näidata tema panus Eesti riigi seadusloomesse

Ruhnu saarele hakkab lennutama Saksa firma / Mehis Tulk, Andres Sepp

Index Scriptorium Estoniae

Tulk, Mehis, 1967-

2006-01-01

Ilmunud ka: Meie Maa 9. nov lk. 1. Riigihankekonkursi Pärnu-Ruhnu-Kuressaare lennuliini teenindamiseks võitnud Saksa firmaga Luftverkehr Friesland Brunzema und Partner KG sõlmib Saare maavalitsus avaliku teenindamise lepingu neljaks aastaks. Kaart

Sõjaväe poliitika / Igor Gräzin

Index Scriptorium Estoniae

Gräzin, Igor, 1952-

2005-01-01

Ilmunud ka: Hiiu Leht 29. nov. lk. 2, Nädaline 1. dets., lk. 2, Koit 1. dets. lk. 6, Meie Maa 2. dets. lk. 2, Põhjarannik, Severnoje Poberezhje 7.dets. lk. 2. Parlamendiliige palgaarmee vajalikkusest

Putini liberaalne imperialism / Hillar Padu

Index Scriptorium Estoniae

Padu, Hillar

2008-01-01

Ilmunud ka: Meie Maa : Teisipäev Autori hinnangul kavatseb Venemaa saada majanduslikult üliriigiks, võitlus energia- ja energeetikaressursside pärast hoogustub, külm sõda on meedias juba ulatuslikku kajastamist leidnud

Tshto god grjadushtshii nam... / Lev Golub

Index Scriptorium Estoniae

Golub, Lev

2008-01-01

Autor analüüsib Eesti majanduse hetkeolukorda ja tulevikku. Ta leiab, et meie valitsus ja peaminister ei näe riigi majanduses mingeid erilisi probleeme ja raskusi, räägitakse nn. pehmest maandumisest

MODALITĂŢI DE EXPRIMARE A ACŢIUNII DE TRAFIC DE PERSOANE ÎN DREPTUL COMPARAT

OpenAIRE

Mihai ŞTEFĂNOAIA

2015-01-01

În prezentul articol autorul urmăreşte să ofere, prin metoda dreptului comparat, soluţii mai bune, specifice, relevante procesului legislativ în interpretarea infracţiunii de trafic de persoane. Obiectul de cercetare al lucrării îl formează urmă-toarele subiecte: conceptul şi natura traficului de persoane; recrutarea, primirea, adăpostirea, ascunderea, transportarea, transferul sau acceptarea persoanelor în vederea exploatării acestora; factorii care contribuie la dezvoltarea traficului de pe...

Kui oled puutunud ussipesa / Ken-Marti Vaher

Index Scriptorium Estoniae

Vaher, Ken-Marti, 1974-

2005-01-01

Ilmunud ka: Sakala 15. november lk. 2, Meie Maa 30. november lk. 2. Ken-Marti Vaher kritiseerib Keskerakonna juhi Edgar Savisaare majaostu Keila-Joal ning kummutab laimu oma perekonna varade kohta nende päritolu selgitades

Клоун устроит представление на орбите

Index Scriptorium Estoniae

2009-01-01

Kanadalane Guy Laliberté, tsirkuse Cirque du Soleil asutaja, lendas kosmoseturistina 30. okt. ISSi Vene kosmoselaevaga Sojuz TMA-16 Bajkonõri kosmodroomilt kosmosesse sotsiaalse missiooniga, et juhtida üldsuse tähelepanu vee puudusele meie planeedil

Eestit külastab 17 USA kindralit

Index Scriptorium Estoniae

2016-01-01

Kaitseväe juhataja kindralleitnant Riho Terras tutvustas eile mereväebaasis 17 Eestis viibivale Ameerika Ühendriikide kõrgemale ohvitserile meie riigikaitsesüsteemi. Enne Eestit käisid õppereisil viibivad ohvitserid Ukrainas ja Moldovas

Arnold Rüütel rikkus betoonpaneelidest kai ehitamisega seadust / Oliver Rand

Index Scriptorium Estoniae

Rand, Oliver, 1971-

2007-01-01

Laimjala vallas Saarekülas president Arnold Rüütli omavolilist ehitustegevust kontrollimas käinud keskkonnainspektorid leidsid, et paadisilla rajamiseks oleks president pidanud taotlema erikasutusluba. Ilmunud ka: Meie Maa (2007) 24. aug. 2007, lk. 1

Eesti kukkus Läänemere kaitsmisel läbi / Madis Filippov

Index Scriptorium Estoniae

Filippov, Madis

2011-01-01

Maailma Looduse fondi raporti "Baltic Sea Scorecard 2011" hinnangul ei ole Läänemere riigid tegelenud mere hoidmisega piisavalt. Kuigi Eesti on teinud üsna palju, on ka meie tegevust hinnatud nõrgima hindega. Karm raport

DVD. Aare Ermel tutvustab / Aare Ermel

Index Scriptorium Estoniae

Ermel, Aare, 1957-2013

2007-01-01

Eluloofilm "Lermontov" : režissöör Nikolai Burljajev : NSV Liit 1986 ja teleseriaal "Petshorin: meie aja kangelane" ("Petshorin: geroi nashego vremeni") : režissöör Aleksandr Kott : nimiosas Igor Petrenko : Venemaa 2006

Majanduse struktuur kujuneb isevoolu / Tiit Made, Rein Kask ; interv. Ester Shank

Index Scriptorium Estoniae

Made, Tiit, 1940-

1999-01-01

Riigikogu majanduskomisjoni esimees Tiit Made ja tema asetäitja Rein Kask nentisid Maailmakaubanduskeskuse klubi kokkutulekul, et kaheksa aasta jooksul ei ole Eesti valitsused suutnud ette näha, millise struktuuriga majandus peaks meie riigis kujunema

Rakvere teater lahkab (koos)elu

Index Scriptorium Estoniae

2009-01-01

Rakvere teatri kevadhooaja kolme esietenduse tutvustus: Eric-Emmanuel Schmitt "Kooselu väikesed kuriteod", lavastaja Erki Aule, Neil Simon "Meie, mehed", lavastaja Toomas Suuman ja Ernest Hemingway "Ja päike tõuseb", lavastaja Jaanika Juhanson

Külalised ja meie / Tiiu Levald

Index Scriptorium Estoniae

Levald, Tiiu, 1940-

2009-01-01

11. detsembril Estonia kontserdisaalis toimunud ERSO kontserdist, dir. Olari Elts ja solist soome metsosopran Monica Groop, kavas oli Wagneri ja Mendelssohni looming ning 12. detsembril Estonias toimunud Donizetti ooperi "Poliuto" kontsertettekandest, dirigent Arvo Volmer

Ringiratast meie vabariigi pealinnas / Jan Kaus

Index Scriptorium Estoniae

Kaus, Jan, 1971-

2004-01-01

Esilinastus mängufilm "Täna öösel me ei maga" : stsenaristid Kristian Taska, Jaan Tätte : režissöör Ilmar Taska : operaator Istvan Borbas : produtsent Kristian Taska : peaosades Carmen Kass, Peter Franzen; Maria Avdjushko, Priit Võigemast : Taska Productions. Esilinastus 4. märts 2004. Lisatud Jaan Tätte, Riina Rõõmuse ja Kaur Kenderi kommentaarid.

Sõda meie ümber / Heigo Kaldra

Index Scriptorium Estoniae

Kaldra, Heigo

2006-01-01

Rets. rmt.: Ed Michaels, Helen Handfield-Jones, Beth Axelrod. "Sõda talentide pärast". Raamat tugineb põhjalikule uurimusele, kus toodud numbrid, protsendid ja näited viitavad ühele ja samale: inimene, tema oskused, teadmised ja kogemused on ettevõtte kalleim vara, mille hoidmisele ja arendamisele tuleb juhtida kõikide juhtide põhitähelepanu

Maailm meie jalge all / Philippe Dayan

Index Scriptorium Estoniae

Dayan, Philippe

2007-01-01

Jalatsidisainerite Stuart Weitzman'i (USA), Jimmy Choo (Inglismaa), Manolo Blahnik'i (USA), Georgina Goodman'i (Inglismaa), Franziska Hübener'i (Brasiilia), Edmundo Castillo (Itaalia), Christian Louboutin'i (Prantsusmaa), Giuseppe Zanotti (Itaalai), Bruno Frisoni (Prantsusmaa), Pierre Hardy (Prantsusmaa) eluloolisi andmeid ja loomingu lühitutvustus

Meie ühine suvi / Silver Meikar

Index Scriptorium Estoniae

Meikar, Silver, 1978-

2007-01-01

Ilmunud ka: Vooremaa, 14. juuli 2007, lk. 2; Võrumaa Teataja, 14. juuli 2007, lk. 2; Nädaline, 14. juuli 2007, lk. 5; Hiiu Leht, 17. juuli 2007, lk. 2; Lääne Elu, 17. juuli 2007, lk. 2; Sakala, 19. juuli 2007, lk. 2; Järva Teataja, 19. juuli 2007, lk. 2; Pärnu Postimees, 20. juuli 2007, lk. 15; Elva Postipoiss, 21. juuli 2007, lk. 4. Pronkssõduri teisaldamisele järgnenud aprillirahutuste õppetundidest rahvussuhete edendamisel ning sise- ja välisjulgeoleku tagamisel

Ryutaro - meie klassi jaapanlane / Eve Kukemelk

Index Scriptorium Estoniae

Kukemelk, Eve

2011-01-01

Tartu Miina Härma gümnaasiumis õppivast jaapani poisist Ryutaro Furukawa'st, kes tuli Eestisse koos oma eestlasest ema ja noorema vennaga pärast Fukushima tuumaelektrijaama katastroofi, maavärina ja tsunami üleelamist

Siin on meie retroparadiis! / Shanti Broeng

Index Scriptorium Estoniae

Broeng, Shanti

2009-01-01

Lan ja Brian Frandseni renoveeritud väikesest suvekodust Kopenhaageni lähedal, millest on taaskasutusmööbli ja värvikate kangastega saanud rõõmus koht perepuhkuseks - stilistiks oli taani sisekujundaja Sidsel Zachariassen

Meie mees Silicon Valleys / Kertu Ruus

Index Scriptorium Estoniae

Ruus, Kertu, 1977-

2007-01-01

Ilmunud ka: Delovõje Vedomosti 5. dets. lk. 4. Peaminister Andrus Ansip avas Eesti Ettevõtluse Sihtasutuse esinduse Silicon Valley pealinnas San Joses. Vt. samas: Ränioru kliima on tehnoloogiasõbralik; Andrus Viirg

Meie ingel Silicon Valleys / Raigo Neudorf

Index Scriptorium Estoniae

Neudorf, Raigo

2008-01-01

Ettevõtluse Arendamise Sihtasutuse esinduse töölepanekust USAs Silicon Valleys räägib esinduse juht Andrus Viirg. Vt. ka: Eestlasi leidub San Franciscos omajagu; Muljetavaldav karjäär; USAga ammune tuttav

Meie mees Berliinis / Lauri Kärk

Index Scriptorium Estoniae

Kärk, Lauri, 1954-

2005-01-01

Berliini 55. filmifestivalist : Eesti filmist festivalil (Euroopa noorte režissööride lühifilmidest koosnevat projekti "Kaotatud ja leitud" raamib Mait Laasi nukufilm "Gener+atio"), inglaseDavid MacKenzie mängufilmist "Pelgupaik" ("Asylum")

Meie televisioon ja raadio / Ela Tomson

Index Scriptorium Estoniae

Tomson, Ela, 1945-

2006-01-01

Rahvusringhäälingu seaduseelnõust. Sama ka Harjumaa 14. juuli 2006, lk. 2 ; Vali Uudised 12. juuli 2006, lk. 2 ; Võrumaa Teataja 18. juuli 2006, lk. 2 ; Valgamaalane 18 . juuli 2006, lk. 2 ; Sakala 19. juuli 2006, lk. 2, pealkiri kujul : Eesti Televisiooni ja Eesti Raadio saatus puudutab meid kõiki ; Põhjarannik 12. juuli 2006, lk. 2 ; Pärnu Postimees 18. juuli 2006, lk. 15 ; Hiiu Leht 14. juuli 2006, lk. 2 ; Nädaline 27. juuli 2006, lk. 2 ; Kuulutaja 28. juuli 2006, lk. 4 ; Sõnumitooja 9. august 2006, lk. 2

Jalgratta leiutamine meie energiapoliitikas? / Rein Hanni

Index Scriptorium Estoniae

Hanni, Rein

2004-01-01

Autor leiab, et Eesti Energia peaks oma strateegiliste eesmärkide seadmisel lähtuma kütuse ja energiamajanduse pikaajalisest riiklikust arengukavast, mille vastuvõtmisega otsustati vähendada põlevkivienergia kasutamist

Meie sotsiaalse kunsti needus / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

2003-01-01

Sotsiaalministeeriumi võrdõiguslikkuse büroo ei tahtnud, et nende organiseeritud III Läänemere naiste konverentsil "Naised, mehed ja demokraatia" näidataks "Valie Export Society" aktsioonide videodokumentatsiooni, konverentsil käsitletud ideede-probleemide visuaalset kandjat

Demokraatiahariduse ideaalide saavutamise võimalused / Kaarel Haav

Index Scriptorium Estoniae

Haav, Kaarel, 1946-

2009-01-01

Meie ühiskonnaõpikutes toonitatakse, et kõikidel inimestel on võrdsed õigused, kuid jäetakse märkimata, et need võrdsete õigustega inimesed kuuluvad eri sotsiaalsetesse struktuuridesse, mis muudavad nende võimalused ebavõrdseks

Mine, Mailis, õige...Helsingisse! / Peeter Kreitzberg

Index Scriptorium Estoniae

Kreitzberg, Peeter, 1948-2011

2007-01-01

Autor kritiseerib Keskerakonna valimislubadusi ametnike palkade tõstmiseks ja kooliõpilaste kultuurireisideks ning leiab, et hariduse ühtlane kättesaadavus ja hariduslike võimaluste võrdsus peaks olema meie tähtsaim strateegiline eesmärk

Kuningas on surnud! Elagu kuningas! / Kalev Kask

Index Scriptorium Estoniae

Kask, Kalev

2005-01-01

Ilmunud ka: Meie Maa 10. august lk. 5. Maailma suurima monarhistliku ja ühe suurema islamiriigi Saudi Araabia uueks kuningaks sai traditsiooniliste tavade järgi peale kuningas Fahdi surma tema poolvend Abdullah. Lisa: Saudi Araabia kuningad

Hea nali võib peituda raamatus / Gert Kiiler

Index Scriptorium Estoniae

Kiiler, Gert

2007-01-01

Arvustus: Leer, Jaak. Savumees Einaril on kogu aeg buss katki. Tallinn : Jutulind, 2006 ; Huber, Markus, Treichler, Robert. Keegi pole nii vinge kui meie : uimased britid, tobedad sakslased, pinges prantslased ja veel 36 lootusetut juhtumit. Tallinn : Olion, 2006

Sõjaajaloolane Ivika Maidre : "Teine maailmasõda lõpeb meis ehk 200 aasta pärast" = Vojennõi istorik Ivika Maidre : "Vtoraja mirovaja voina zakontshitsja v nas let, mozhet, tsherez 200" / Ivika Maidre ; interv. Erik Kalda

Index Scriptorium Estoniae

Maidre, Ivika

2007-01-01

Autor arvab, et viimase sõja lõppemine meie hinges võib sündida alles mitmete inimpõlvede järel - niikaua tuleb otsida võimalusi kokku leppida. Ilmunud ka: Severnoje Poberezhje : Subbota, 5. mai 2007

Kui naljamehed pürgisid 1920. aastal riigikokku / Olaf Esna

Index Scriptorium Estoniae

Esna, Olaf, 1934-

2009-01-01

Pilkeajakirjast "Meie Mats" ja selle tegijate kandideerimisest I riigikogu valimistel 1920. aastal. 1920. aastal ajakirja toimetanud kirjanik Henrik Saarest (alias Kivilombi Ints) ja karikaturist Georg Tõnissonist (alias Gori). Nimekiri riigikogu valimistel, programmist ja hääletustulemustest

Põrgulikud piinad ja tingimusteta armastus / Margit Tõnson

Index Scriptorium Estoniae

Tõnson, Margit, 1978-

2004-01-01

Helsingis 17. korda toimuva festivali "Armastus ja Anarhia" kavas olnud filme - Takashi Miike "Üks vastamata kõne" ("One Missed Call"), korealase Park Chan-Wooki "Vana poiss" ("Old Boy") ja Jean-Luc Godardi "Meie muusika" ("Notre Musique")

Imbalance of tumor necrosis factor receptors during progression in bovine leukemia virus infection

International Nuclear Information System (INIS)

Konnai, Satoru; Usui, Tatsufumi; Ikeda, Manabu; Kohara, Junko; Hirata, Toh-ichi; Okada, Kosuke; Ohashi, Kazuhiko; Onuma, Misao

2005-01-01

Previously, we found an up-regulation of tumor necrosis factor alpha (TNF)-α and an imbalance of TNF receptors in sheep experimentally infected with bovine leukemia virus (BLV). In order to investigate the different TNF-α-induced responses, in this study we examined the TNF-α-induced proliferative response and the expression levels of two distinct TNF receptors on peripheral blood mononuclear cells (PBMC) derived from BLV-uninfected cattle and BLV-infected cattle that were aleukemic (AL) or had persistent lymphocytosis (PL). The proliferative response of PBMC isolated from those cattle with PL in the presence of recombinant bovine TNF-α (rTNF-α) was significantly higher than those from AL cattle and uninfected cattle and the cells from PL cattle expressed significantly higher mRNA levels of TNF receptor type II (TNF-RII) than those from AL and BLV-uninfected cattle. No difference was found in TNF-RI mRNA levels. Most cells expressing TNF-RII in PL cattle were CD5 + or sIgM + cells and these cells showed resistance to TNF-α-induced apoptosis. Additionally, there were significant positive correlations between the changes in provirus load and TNF-RII mRNA levels, and TNF-α-induced proliferation and TNF-RII mRNA levels. These data suggest that imbalance in the expression of TNF receptors could at least in part contribute to the progression of lymphocytosis in BLV infection

Modulating Leukemia-Initiating Cell Quiescence to Improve Leukemia Treatment

Science.gov (United States)

2015-09-01

T- cells and in innate immunity (Lacorazza et al., 2002). It controls the proliferation and homing of CD8+ T- cells via the Kruppel-like factors...Lin2Sca12IL7R2Kit1FccRII/ IIIhighCD34high), megakaryocyte-erythroid progenitor cell (MEP) (Lin2Sca12IL7R2Kit1FccRII/IIIlowCD34low), and common lymphoid ...to this model, the first wave gives rise exclusively to innate immune B cells in early embryonic life and may be derived from progenitor cells

Experiments and dialogue are pushing agendas

DEFF Research Database (Denmark)

Hartmann-Petersen, Katrine

2018-01-01

In 2004, the Danish researcher Søren Riis and his business partner Matias Mølgaard were students in Germany. Inspired by the well-coordinated carpooling system, Mitfahrzentrale, they conceptualized and founded GoMore. GoMore is now the biggest car sharing and carpooling company in Denmark...... with growing markets all over Scandinavia and in Spain. GoMore is the first company to combine ride sharing and car sharing in one system. In this conversation with Katrine Hartmann-Petersen, Søren Riis elaborates on his experiences on sharing economies and the future of sustainable urban mobilities....

Eesti NATO ukselävel / Mari-Ann Kelam

Index Scriptorium Estoniae

Kelam, Mari-Ann, 1946-

2002-01-01

Seda, et NATO liitumisläbirääkimistele kutsutavate seas on ka Eesti, saab veel tänagi pidada üheks meie iseseisva riikluse suursaavutuseks, kui mitte imeks, kirjutab Riigikogu liige Mari-Ann Kelam. Autor: Isamaaliit. Parlamendisaadik

Mis/MOODI kannab ühiskond? / Jaanus Vahtra

Index Scriptorium Estoniae

Vahtra, Jaanus, 1974-

1998-01-01

Moe ja ühiskonna suhetest, olukorrast praeguses Eestis, ebaloomulikult teravdatud tähelepanust moe vastu meie meedias. Teemad : Mood ja teised kunstid. Mood ja kood. Väärtuste teadvustamine. Enesemääratlus ja kood. Meedia ja eneseteadvus.

Buu, buu, buu, buu! / Igor Gräzin

Index Scriptorium Estoniae

Gräzin, Igor, 1952-

2008-01-01

Uue töölepingu seaduse eelnõust. Ilmunud ka Põhjarannik 30. jaan. 2008, lk. 2, pealkiri kujul: Ametiühingud: buuu... buuu... buuu... ; Meie Maa 1. veeb. 2008, lk. 2 ; Elva Postipoiss 2. veeb. 2008, lk. 2

WHO ekspert : Eesti meditsiin vajab rahu / Joseph Kutzin ; interv. Sigrid Laev

Index Scriptorium Estoniae

Kutzin, Joseph

2004-01-01

WHO Euroopa tervisesüsteemide finantsnõustaja annab hinnangu Eesti meditsiinisüsteemi arengule ning leiab, et SKT-st tervishoiule eraldatud 5% ei ole meie sissetulekuga riigi puhul erandlik. Suureks probleemiks peab ta aidsi levikut. Lisa: Ressursid ammendumas

About meat, trade, own-label brand products : [Eesti kauplusekettides] / Roomet Sõrmus

Index Scriptorium Estoniae

Sõrmus, Roomet, 1979-

2010-01-01

Kauplusekettide survele on võimalik vastu hakata, kui nad omatoodete sildi all hakkavad müüma sissetoodud odavast toorainest valmistatud toiduaineid ja püüavad nii meie põllumeeste toodetud toitu välja tõrjuda

Aafrika mängufilm Tartu festivalil / Mathura

Index Scriptorium Estoniae

Mathura, pseud., 1973-

2006-01-01

Tartus visuaalse kultuuri festivalil Maailmafilm linastunud aafrika mängufilmidest - Burkina Faso filmid "Tasuma" (rezh. Kollo Daniel Sanou) ja "Mina ja mu valge sõber" (rezh. S. Pierre Yameogo), Tšaadi film "Meie isa" (rezh. Mahamat Saleh Haroun)

Tsirkus Barcelona / Andrus Villem

Index Scriptorium Estoniae

Villem, Andrus

2005-01-01

Ilmunud ka: Meie Maa, Vooremaa 25. august lk. 2,2, Virumaa Teataja, Hiiu Leht, Põhjarannik 26. aug. lk. 7,2,2, Lääne Elu 27. aug. lk. 2. Autor kritiseerib Keskerakonna ja Reformierakonna kohalike valimiste eelset propagandat

Läänemerel ilmus Kinobussile kolleeg / J. R.

Index Scriptorium Estoniae

J. R.

2008-01-01

9. augustil algab Narva-Jõesuus filmi- ja keskkonnateemaline festival Moving Baltic Sea, mille eestvedajaks on Saksa rändfilmifestivali Moviemiento korraldajad. Festival sai 4. juulil alguse Rostockist ja liigub 100-aastasel purjekal Lovis. Eestis osaleb ka meie Kinobuss

Mart Laar - visionäärina kuulsam välismaal / Kertu Ruus

Index Scriptorium Estoniae

Ruus, Kertu, 1977-

2005-01-01

Maailmas on kümneid riike, kes imetlevad meie endise peaministri Mart Laari reforme Eestis. Kommenteerivad Margaret Thatcher, Alfredo Arias-King ja Tiit Vähi. Vt. samas: Väljavõtteid Mart Laari kohta ajakirjandusest; Laia haardega tegutseja: Liikmelisus

Armukarneval presidendi autos / Mart Juur

Index Scriptorium Estoniae

Juur, Mart, 1964-

2002-01-01

Kolmest eesti enimmüüdud plaadist: Uno Kaupmees "Igavesti Noor", Anne Veski "Armukarneval", Meie Mees "Pööning põleb" ja kolmest Areeni kriitikute lemmikplaadist: Moodymann "Forevernevermore", Una Bomba "Aerosol", N*E*R*D "In Search of..."

Papa Carlo teater filmitudengite moodi / Kairit Tsäro

Index Scriptorium Estoniae

Tsäro, Kairit, 1974-

2002-01-01

Concordia ülikooli ja TPÜ tudengid lõpetasid õppejõudude Ilmar Raagi ja Ian M. Fraseri juhendamisel kõmumeediat parodeeriva lühimängufilmi "Meie lemmikud". Stsenarist ja režissöör on Hanna Shein

Täiendame teadmisi kogu elu / Toomas Hendrik Ilves

Index Scriptorium Estoniae

Ilves, Toomas Hendrik, 1953-

2007-01-01

President Toomas Hendrik Ilvese kõne teadmiste päeval 1. septembril 2007 Eesti Televisioonis. Ilmunud ka: Hiiu Leht 4. sept. 2007, lk. 2, pealk.: Presidendi kõne teadmiste päeval (lüh.); Virumaa Teataja 4. sept. 2007, lk. 11, pealk.: Koolipinki peaksid minema ka paljud täiskasvanud; Sakala 4. sept. 2007, lk. 2, pealk.: Võtkem tempot maha ja mõelgem oma tegudele!; Pärnu Postimees 4. sept. 2007, lk. 19, pealk.: Vabariigi presidendi kõne 1. septembril; Põhjarannik 4. sept. 2007, lk. 4, pealk.: Keegi pole õppimiseks liiga tark; Severnoje Poberezhje 4. sept. 2007, lk. 4; Võrumaa Teataja 4. sept. 2007, lk. 2, pealk.: Teadmiste päev on meie kõigi päev; Molodjozh Estonii 3. sept. 2007, lk. 2; Meie Kodu 12. sept. 2007, lk. 1, pealk.: Presidendi pöördumine 1. septembril

Evaluation of umbilical cord blood CD34+ hematopoietic stem cells expansion with inhibition of TGF-β receptorII in co-culture with bone marrow mesenchymal stromal cells.

Science.gov (United States)

Sohrabi Akhkand, Saman; Amirizadeh, Naser; Nikougoftar, Mahin; Alizadeh, Javad; Zaker, Farhad; Sarveazad, Arash; Joghataei, Mohammad Taghi; Faramarzi, Mahmood

2016-08-01

Umbilical cord blood (UCB) is an important source of hematopoietic stem cells (HSCs). However, low number of HSCs in UCB has been an obstacle for adult hematopoietic stem cell transplantation. The expansion of HSCs in culture is one approach to overcome this problem. In this study, we investigated the expansion of UCB-HSCs by using human bone marrow mesenchymal stromal cells (MSCs) as feeder layer as well as inhibiting the TGF-β signaling pathway through reduction of TGF-βRII expression. CD34(+) cells were isolated from UCB and transfected by SiRNA targeting TGF-βRII mRNA. CD34(+) cells were expanded in four culture media with different conditions, including 1) expansion of CD34(+) cells in serum free medium containing growth factors, 2) expansion of cells transfected with SiRNA targeting TGF-βRII in medium containing growth factors, 3) expansion of cells in presence of growth factors and MSCs, 4) expansion of cells transfected with SiRNA targeting TGF-βRII on MSCs feeder layer in medium containing growth factors. These culture conditions were evaluated for the number of total nucleated cells (TNCs), CD34 surface marker as well as using CFU assay on 8th day after culture. The fold increase in CD34(+) cells, TNCs, and colony numbers (71.8±6.9, 93.2±10.2 and 128±10, respectively) was observed to be highest in fourth culture medium compared to other culture conditions. The difference between number of cells in four culture media in 8th day compared to unexpanded cells (0day) before expansion was statistically significant (P<0.05). The results showed that transfection of CD34(+) cells with SiRNA targeting TGF-βRII and their co-culture with MSCs could considerably increase the number of progenitors. Therefore, this method could be useful for UCB-HSCs expansion. Copyright © 2016 Elsevier Ltd. All rights reserved.

Inequalities in Health Services Usage in a National Health System Scheme: The Case of a Southern Social European Region.

Science.gov (United States)

Morteruel, Maite; Rodriguez-Alvarez, Elena; Martin, Unai; Bacigalupe, Amaia

Health services can reduce inequalities caused by other determinants of health or increase them due to the effect of the inverse care law-the principle that the availability of good quality care tends to vary inversely with the need for it in the population served. The purpose of the research was to describe inequalities in the use of nursing services, medical services in primary care, specialist care, and services not fully covered by the Basque public health system in Spain. A cross-sectional study of adults aged at least 25 years who completed the 2013 Basque Health Survey (N = 10,454) was conducted. Age-standardized prevalence and prevalence ratios for use of services that are covered and noncovered in the health system were computed. The association of health services usage with socioeconomic variables was estimated using a Poisson regression model with robust variance. The relative index of inequality (RII) was used to measure the magnitude of socioeconomic status inequalities in health service use. All analyses were carried out separately for men and women. Individuals with lower socioeconomic status were more likely to use primary care (RII = 0.87, 95% CI [0.79, 0.97]) and less likely to use specialist services (RII = 0.82, 95% CI [0.75, 0.89]). Across noncovered health services, inequalities between the highest and lowest social groups were significant in all cases and especially marked in men's use of physiotherapists (RII = 0.46, 95% CI [0.35, 0.61]) and podiatrists (RII = 0.24, 95%CI [0.15, 0.38]). There are significant inequalities in primary and specialist health service use based on individual socioeconomic status, particularly for services that are not provided free of charge within the existing health system. This suggests that health service systems that are not explicitly designed to provide universal access may actually amplify preexisting social and health inequalities within their target populations.

Valmib valus lavalugu perest : Athenas jõuab vaatajate ette Mart Kivastiku suhtedraama / Raimu Hanson

Index Scriptorium Estoniae

Hanson, Raimu, 1957-

2008-01-01

SA Eesti Teatri Festival esietendab 4. mail Athena keskuses Margus Kasterpalu lavastuses Mart Kivastiku näidendit "Meie isa, kes sa oled ..." Mängivad Vanemuise näitlejad Marika Aidla, Hannes Kaljujärv, Tanel Jonas ning Leino Rei

Lionsi asepresident kiitis Eesti "lõvisid" / Marika Milve

Index Scriptorium Estoniae

Milve, Marika, 1968-

1995-01-01

Lions klubi Eestis. Vt. ka Meie Maa "Lionsite maailma-assotsiatsiooni teine asepresident Augustino Solivo külastas Saaremaad" 8- juuni, lk. 1, Oma Saar "Augustino Soliva: tavaliselt oskavad inimesed võtta, kuid ei oska anda" 7. juuni, lk. 3

Iga laps on kallisvara - poisid kaasa arvatud : mille eest õpetajatele palka makstakse / Tiia Lister

Index Scriptorium Estoniae

Lister, Tiia

2006-01-01

Meie koolides on lapsi, eriti poisse, keda on vaja toetada nii kooli kui ka kodu poolt, et nad saaksid hariduse ja jõuaks kasvada küpseks inimeseks, õpetajatele selle eest palka makstaksegi, et nad õpetaksid kõiki lapsi

Poliitikas on palju võimalik / Väino Linde

Index Scriptorium Estoniae

Linde, Väino, 1959-

2005-01-01

Ilmunud ka: Vali Uudised, Meie Maa 1. apr. lk. 2, Koit 2. apr. lk. 6, Hiiu Leht 5. apr. lk. 2. Parlamendiliige lahkab momendi poliitilist olukorda, teeb ülevaate Riigikogu juhatuse valimisest ning usub Reformierakonna jätkamist valitsuskoalitsioonis

Algamas on "Kahe ilu festival" / Silja Joon

Index Scriptorium Estoniae

Joon, Silja, 1966-

2008-01-01

Pärnus 14.-16. novembrini kestva kirjanduse ja muusika festivali "Kahe ilu festival" eelinfo - korraldavad Vaimse Rutiini Preventsiooni Sihtasutus, Kultuurilabor, Pärnu ooper ja Kunstide Maja, festivali raames toimub luulemaraton ning kõnekoosolek "Meie igapäevane põrgu"

Surmanuhtlus - õiglane või mitte / Kalev Kask

Index Scriptorium Estoniae

Kask, Kalev

2007-01-01

Artiklis käsitletakse küsimust, kas surmanuhtlust pidada õiglaseks karistuseks või pole selle täitmine demokraatlikus ühiskonnas küllaldaselt õigustatud. Ilmunud ka Meie Maa : Nädalalõpp 19-20. jaan. 2007, lk. 3

"Klassivaenlase poolt on organiseeritud rida mitmesuguseid nõukogude vastaseid väljendusi..." / Tiit Noormets

Index Scriptorium Estoniae

Noormets, Tiit, 1959-

2016-01-01

Parteiinformatsioonid olid mitmekesise sisuga. Eri aegadel ja maakondades koostatud informatsioonid olid erineva väärtusega. Suurem väärtus on informatsioonides jäädvustatud värvikates seikades ja ütlustes, mis aitavad meie ajaloopilti elavadada

F.F.F.F. armastab mõtestada ennast / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

2002-01-01

Rühmituse F.F.F.F. (Kristi Paap, Kaire Rannik, Berit Teeäär, Ketli Tiitsar, Maria Valdma) näitus "Meie igapäevane leib" 9. novembrini Hansapanga galeriis ja näitus "Pentagramm" 26. X-1. XII Tarbekunstimuuseumis

Verest saab vein : [luuletused] / Mare Osi

Index Scriptorium Estoniae

Osi, Mare

2003-01-01

Sisu: "Must üü nigu kaaren ..." ; Metamorfoos ; Pettumus ; Skeptiline ; Talisman ; Unetet latsepõli ; Meie kaits ; Sannaõhtu ; "Külmä süä lüüdi lõhki ..." ; "Egäl kevädil ...". Eluloolisi andmeid autori kohta lk. 193

Vene püstolid lähevad sulatusahju / Raivo Tamm ; interv. Piret Tali

Index Scriptorium Estoniae

Tamm, Raivo

2004-01-01

Eesti loobub Makarov-püstolitest, sest meie relvastus peab vastama NATO-s kehtivatele kaliibritele. Nende asemel kaalutakse Walteri, Sig-Saueri, Heckler & Kochi ja Glocki relvade ostu. Lisa: Walter P99 QA, Sig Sauer P226, Heckler & Koch USP, Glock

Harry Potter tungib peale igast suunast / Hindrek Riikoja

Index Scriptorium Estoniae

Riikoja, Hindrek

2001-01-01

Eesti kauplustes saadab suur müügiedu kõikvõimalikke mänguasju, kleepse ja muud atribuutikat mis seondub Joanne Rowling'u Potteri-raamatutega ja nüüd ka meie kinno jõudnud "Harry Potter ja Tarkade kivi" ekraniseeringuga

Kõlavad laulud Eestile / Silja Joon

Index Scriptorium Estoniae

Joon, Silja, 1966-

2008-01-01

Narva linna sümfooniaorkester ja Pärnu kammerkoor annavad 15. ja 16. nov. Pärnus ja Pärnumaal kontserdi "Palju õnne, meie Eesti!", esitatakse eesti heliloojate teoseid, flöödil soleerib Leonora Palu, dirigeerivad Ave Sopp ja Anatoli Shtshura

Idealismi kaotus / Jarno Laur

Index Scriptorium Estoniae

Laur, Jarno, 1975-

2004-01-01

Ilmunud ka: Koit, 23. nov. 2004, lk. 6; Meie Maa, 25. nov. 2004, lk. 2; Hiiu Leht, 26. nov. 2004, lk. 2; Vooremaa, 27. nov. 2004, lk. 2; Sakala, 30. nov. 2004, lk. 2. Sotsiaaldemokraadist parlamendiliikme kriitika Res Publica aadressil

"Detsembrikuumuse" helirežissöör sai Emmy

Index Scriptorium Estoniae

2008-01-01

Hollywoodis töötav helirežissöör Solange S. Schwalbe sai septembris Los Angeleses toimunud 2007-2008 Creative Arts Primetime Emmys tseremoonial Emmy minisarja "John Adams" heliefektide eest. Tema meeskond helindas ka meie uue mängufilmi

Soome turist otsib Eestist loodust ja kultuuri / Hindrek Riikoja

Index Scriptorium Estoniae

Riikoja, Hindrek

2002-01-01

Eesti turismifirmad püüavad Eestit soomlastele müüa eelkõige meie looduse ja kultuurisündmuste kaudu. Helsingis toimuv turismimess. Tabel: Eestis käis üle 3 miljoni turisti. Vt. samas "Soome majanduslangus toob Eestile kasu"

Planeetide rivistus pakub sajandi vaatemängu / Villu Päärt

Index Scriptorium Estoniae

Päärt, Villu, 1972-

2002-01-01

Viis planeeti - Merkuur, Veenus, Marss, Saturn ja Jupiter koonduvad 20. aprillist kuuks ajaks õhtutaevas rivvi, mida näeb uuesti alles saja aasta pärast. Skeem : Meie päikesesüsteemi planeedid; Planeedid ühes reas; Kuu varjutab Saturni

Usalda, aga kontrolli / Manuela Pihlap

Index Scriptorium Estoniae

Pihlap, Manuela

2008-01-01

Uuest isikuandmete kaitse seadusest. Ilmunud ka Harju Ekspress 22. veeb. 2008, lk. 6 ; Meie Maa 26. veeb. 2008, lk. 2 ; Pärnu Postimees 28. veeb. 2008, lk. 15 ; LõunaLeht 28. veeb. 2008, lk. 4 ; Valgamaalane 28. veeb. 2008, lk. 2

Pärnu muuseumis näeb vammuseid ja pesu / Karin Klaus

Index Scriptorium Estoniae

Klaus, Karin

2009-01-01

Näitus "Meie vammus" Pärnu Muuseumis, koostaja Ülli Kont. Viljandi Muuseumi rändnäitus "Need" Pärnu Muuseumis, koostajad Tiina Jürgen, Ebe-Triin Arros, Lüüli Kiik, Herki Helves. Näitused on avatud 12. septembrini

Tiheduse kurvid / Michael Sorkin

Index Scriptorium Estoniae

Sorkin, Michael

2007-01-01

Autor toob välja linnade kasvu mõju maa ökoloogiale. Tema sõnul on demokraatliku linna jaoks kriitiline tihedus linlike vormide ning käitumisviiside tihke kogum ning just tiheduses on vastus jätkusuutlikuks edasi elamiseks meie planeedil

Euro pole eesmärk, vaid vahend heaolu poole / Jüri Ratas

Index Scriptorium Estoniae

Ratas, Jüri, 1978-

2009-01-01

Riigikogu liige kritiseerib IRLi juhi Mart Laari tegevust peaministrina ja mõtet, et Eesti peab seadma üheseks ja kõiki teisi prioriteete allutavaks tegevussuunaks eurole ülemineku. Ta leiab, et eurole üleminek peab olema osa meie pikaajalisest strateegiast

2005 - aasta, mil loodus suunas globaalset päevakorda / Dag Hartelius ; tõlk. Kadri Liik

Index Scriptorium Estoniae

Hartelius, Dag

2005-01-01

Aasta 2005 on toonud julgeolekuaruteludes esiplaanile loodusõnnetused, kliimamuutuse ja energiaküsimused. Tuumatemaatika on taas päevakorral, samal ajal kui võitlus terrorismiga on juba osa meie argikäitumisest ja -mõtlemisest. Euroopa ainus tulevikutee on avatus

The upgrade of nuclear material accounting system at KAERI

International Nuclear Information System (INIS)

Kim, Hyun Jo; Kim, Hyun Sook; Park, Ho Jun; Ko, Han Suk; Lee, Byung Doo

2010-01-01

The agreement between the government of Republic Of Korea (ROK) and the IAEA for the application of safeguards was signed and entered into force in 1975. The Additional Protocol (AP) to the Safeguards Agreement between the ROK and the IAEA was signed in 1999 and entered into force on 19 February 2004. Also, Implementation of Integrated Safeguards (IS) was started on 1 July, 2008 after a draw of the broader conclusion. The IAEA provides 2 hours notification for Random Interim Inspection (RII) under IS. For RII, the facility has to prepare the inspection documents in a short time. Therefore, KAERI (Korea Atomic Energy Research Institute) developed a new computerized nuclear material accounting system named KASIS (KAERI Safeguards Information treatment System) to treat the data by on-line for RII. For the efficient IS implementation, KAERI has a plan to upgrade the system to reflect the accounting approaches or reporting procedure according to facility characteristic. This paper describes the upgrade of the nuclear material accounting system and the efforts to reduce the burden of the facility operators

Armonizarea legislației românești cu legislația comunitară în domeniul protecției mediului

Directory of Open Access Journals (Sweden)

Cristina DOBROTĂ

1999-01-01

Full Text Available În perioada actuală protecţia mediului este o problemă majoră a umanităţii. Activitatea omului orientată spre valorificarea resurselor naturale, a afectat întotdeauna starea mediului. În trecut intervenţia omului în modificarea condiţiilor de mediu era de proporţii reduse şi nu lăsa urme, datorită capacităţii de regenerare a naturii. În secolul nostru, secolul dezvoltării explozive a tuturor activităţilor umane, în special a activităţii din sectoarele industriei, agriculturii, comerţului, turismului si urbanizării, intervenţia omului în modificarea mediului a depăşit pragurile limită de regenerare ale naturii. Asistăm astăzi la o poluare şi la o degradare ireversibilă a mediului. Este pusă în pericol însăşi viaţa oamenilor dacă nu se iau măsuri de limitare şi eliminare a poluării.

Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals.

Science.gov (United States)

Dugast, Anne-Sophie; Tonelli, Andrew; Berger, Christoph T; Ackerman, Margaret E; Sciaranghella, Gaia; Liu, Qingquan; Sips, Magdalena; Toth, Ildiko; Piechocka-Trocha, Alicja; Ghebremichael, Musie; Alter, Galit

2011-07-05

In addition to neutralization, antibodies mediate other antiviral activities including antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cellular cytotoxicity (ADCC), as well as complement deposition. While it is established that progressive HIV infection is associated with reduced ADCC and ADCP, the underlying mechanism for this loss of function is unknown. Here we report considerable changes in FcR expression over the course of HIV infection on both mDCs and monocytes, including elevated FcγRI expression in acute HIV infection and reduced expression of FcγRII and FcγRIIIa in chronic HIV infection. Furthermore, selective blockade of FcγRII alone was associated with a loss in ADCP activity, suggesting that FcγRII plays a central role in modulating ADCP. Overall, HIV infection is associated with a number of changes in FcR expression on phagocytic cells that are associated with changes in their ability to respond to antibody-opsonized targets, potentially contributing to a failure in viral clearance in progressive HIV-1 infection. Copyright © 2011 Elsevier Inc. All rights reserved.

Decreased Fc-Receptor expression on innate immune cells is associated with impaired antibody mediated cellular phagocytic activity in chronically HIV-1 infected individuals

Science.gov (United States)

Dugast, Anne-Sophie; Tonelli, Andrew; Berger, Christoph T.; Ackerman, Margaret E.; Sciaranghella, Gaia; Liu, Qingquan; Sips, Magdalena; Toth, Ildiko; Piechocka-Trocha, Alicja; Ghebremichael, Musie; Alter, Galit

2011-01-01

In addition to neutralization, antibodies mediate other antiviral activities including antibody-dependent cellular-phagocytosis (ADCP), antibody dependent cellular-cytotoxicity (ADCC), as well as complement deposition. While it is established that progressive HIV infection is associated with reduced ADCC and ADCP, the underlying mechanism for this loss of function is unknown. Here we report considerable changes in FcR expression over the course of HIV infection on both mDCs and monocytes, including elevated FcγRI expression in acute HIV infection and reduced expression of FcγRII and FcγRIIIa in chronic HIV infection. Furthermore, selective blockade of FcγRII alone was associated with a loss in ADCP activity, suggesting that FcγRII plays a central role in modulating ADCP. Overall, HIV infection is associated with a number of changes in FcR expression on phagocytic cells that are associated with changes in their ability to respond to antibody-opsonized targets, potentially contributing to a failure in viral clearance in progressive HIV-1 infection. PMID:21565376

Mother's education and offspring asthma risk in 10 European cohort studies.

Science.gov (United States)

Lewis, Kate Marie; Ruiz, Milagros; Goldblatt, Peter; Morrison, Joana; Porta, Daniela; Forastiere, Francesco; Hryhorczuk, Daniel; Zvinchuk, Oleksandr; Saurel-Cubizolles, Marie-Josephe; Lioret, Sandrine; Annesi-Maesano, Isabella; Vrijheid, Martine; Torrent, Maties; Iniguez, Carmen; Larranaga, Isabel; Harskamp-van Ginkel, Margreet W; Vrijkotte, Tanja G M; Klanova, Jana; Svancara, Jan; Barross, Henrique; Correia, Sofia; Jarvelin, Marjo-Riitta; Taanila, Anja; Ludvigsson, Johnny; Faresjo, Tomas; Marmot, Michael; Pikhart, Hynek

2017-09-01

Highly prevalent and typically beginning in childhood, asthma is a burdensome disease, yet the risk factors for this condition are not clarified. To enhance understanding, this study assessed the cohort-specific and pooled risk of maternal education on asthma in children aged 3-8 across 10 European countries. Data on 47,099 children were obtained from prospective birth cohort studies across 10 European countries. We calculated cohort-specific prevalence difference in asthma outcomes using the relative index of inequality (RII) and slope index of inequality (SII). Results from all countries were pooled using random-effects meta-analysis procedures to obtain mean RII and SII scores at the European level. Final models were adjusted for child sex, smoking during pregnancy, parity, mother's age and ethnicity. The higher the score the greater the magnitude of relative (RII, reference 1) and absolute (SII, reference 0) inequity. The pooled RII estimate for asthma risk across all cohorts was 1.46 (95% CI 1.26, 1.71) and the pooled SII estimate was 1.90 (95% CI 0.26, 3.54). Of the countries examined, France, the United Kingdom and the Netherlands had the highest prevalence's of childhood asthma and the largest inequity in asthma risk. Smaller inverse associations were noted for all other countries except Italy, which presented contradictory scores, but with small effect sizes. Tests for heterogeneity yielded significant results for SII scores. Overall, offspring of mothers with a low level of education had an increased relative and absolute risk of asthma compared to offspring of high-educated mothers.

The impact of governmental antismoking policy on socioeconomic disparities in cigarette smoking in South Korea.

Science.gov (United States)

Khang, Young-Ho; Yun, Sung-Cheol; Cho, Hong-Jun; Jung-Choi, Kyunghee

2009-03-01

With enactment of the 1995 Health Promotion Act, the Korean government has developed numerous antismoking policies, including smoke-free buildings and zones, a public media campaign, and tobacco taxation. The present study examined whether governmental antismoking policy during the past decade was associated with reduced socioeconomic differentials in cigarette smoking in South Korea. Data from 99,980 men and 105,193 women aged 25-64 years were analyzed from four rounds of Social Statistical Surveys of Korea between 1995 and 2006. Socioeconomic position (SEP) indicators were education, occupational class, employment status, and household income. Age-adjusted prevalence of smoking was calculated. Prevalence ratios and the relative index of inequality (RII) were estimated using log-binomial regression analysis. Absolute socioeconomic differentials in age-adjusted prevalence of smoking increased between 1995 and 2006. Increases were found in both men and women. Prevalence ratios and RIIs also showed widening relative inequalities in smoking in all four SEP indicators in men. For women, increases in RIIs for education and income were statistically significant. The magnitude of change in prevalence ratios and RIIs by SEP indicators between 1999 and 2003 was statistically significant, whereas the difference between 2003 and 2006 was not. Despite reducing overall cigarette smoking rates in males, the governmental antismoking policies of South Korea did not reduce socioeconomic inequalities in smoking in both genders. However, the recent tobacco taxation policy is likely to dampen the ever-increasing trends in smoking inequalities. More progressive antismoking policies to reduce socioeconomic inequalities in smoking are warranted in South Korea.

ELEMENTE ALE MANAGEMENTULUI DEZVOLTĂRII DURABILE

Directory of Open Access Journals (Sweden)

Pompei COCEAN

2008-12-01

Full Text Available Sustainable Development Management. Our paper focuses on defining the concept of sustainable from a geographical point of view as it compulsory has a territorial connotation, a spatial one that is characteristic of any geographical study. As a result we started from the premises that its defining elements were territorial cohesion, environmental preservation, natural resources preservation, demographical optimum, economic development, and social harmony. As the development phenomenon is not a linear one, neither lacking convulsions nor contradictions, it supposes, in order to be sustainable, an appropriate management. This management includes the following main aspects: use of renewable resources, resources complementarity, optimum relationship between population and resources, tolerable anthropic pressure, harmonisation of request and offer relationship, resilience to climatic change and permanent dissipation of negative impact in nature and in society. The conclusion of our study points out the complexity of the phenomenon of sustainable development, and also the possibility of optimising it through permanent and inspired management.

Valitsus ei täida oma lubadusi / Andres Varik

Index Scriptorium Estoniae

Varik, Andres, 1952-

2000-01-01

2001. aasta riigieelarve eelnõu kriitika. Tabel: Põllumajanduse otsetoetused Eestis 1997-2001. Autor: ERL. Parlamendisaadik. Ilmunud ka: Nädaline 31. okt. lk. 5; Valgamaalane 26. okt., Pärnu Postimees 31. okt.; Hiiu Leht 31. okt. lk. 2; Meie Maa 31. okt. lk. 6

Eesti valib Lääne ja Ida vahel / David Vseviov

Index Scriptorium Estoniae

Vseviov, David, 1949-

2009-01-01

Euroreferendumist. Peamiseks valikuks 14. septembril oli autori hinnangul järeltulijate elukeskkond. Eesti riigi eksistentsiaalseks põhiküsimuseks jääb lähitulevikus riiklik iseolemine, mis pole meie geopoliitilise asendi tõttu võimalik mingisse suuremasse ühendusse kuulumata

Vastakad vaated : Eesti ja eestlaste käsitlustest taasiseseisvusaegses filmikunstis / Mari Laaniste

Index Scriptorium Estoniae

Laaniste, Mari, 1977-

2011-01-01

Käsitletakse Eesti mängufilme, kus püüdlus näidata Eestit soodsas valguses ja vormida ekraanil positiivset rahvuslikku kuvandit on kõige ilmsem. Isamaalisuse trendist meie filmides, selle konarustest ja kriitikast ning masendavatest Eesti-peegeldustest teiste riikide filmides

Kõigile lastele võrdne sünnitoetus / Margi Ein

Index Scriptorium Estoniae

Ein, Margi, 1950-

2005-01-01

Peretoetuste seaduse muutmise seaduse eelnõust, mille järgi sünnitoetus ja lapsendamistoetus tõusevad 5000 kroonini lapse kohta. Sama ka Koit 26. nov. 2005, lk. 6 ; vali Uudised 7. dets. 2005, lk. 2 ; Meie Maa 7. dets. 2005, lk. 2

Kas tulevik on kohal? / Kristjan Port

Index Scriptorium Estoniae

Port, Kristjan, 1960-

2012-01-01

Arvuti- ja tehnoloogiaettevõte IBM tõi 2008. aastal välja viis innovaatilist ideed, mis nende arvates viie aasta pärast kõige enam meie tööd ja elu mõjutavad. Kas need ennustused on täitunud?

ENPA valis uueks esimeheks de Puigi / Andres Herkel

Index Scriptorium Estoniae

Herkel, Andres, 1962-

2008-01-01

Ilmunud ka: Hiiu Leht 22. jaan., lk. 2. Meie Maa 24. jaan. lk. 2. Euroopa Nõukogu parlamentaarne assamblee valis oma uueks presidendiks Hispaania sotsialisti Lluis Maria de Puigi. Briti konservatiivide ja Ühtse Venemaa koostööst, mida juhib Mihhail Margelov

Füüsikutele koidab peagi tõe hetk / Alo Lõhmus

Index Scriptorium Estoniae

Lõhmus, Alo

2008-01-01

Sel nädalal käivitatud maailma suurima osakeste kiirendi LHC peamine ülesanne on kinnitada või ümber lükata standardmudel, mis võtab kokku meie arusaamad elementaarosakestest ning looduse fundamentaaljõududest. Lisa: Suur hadronite põrguti (LHC) arvudes

Feng shui taevased olendid / Ann Tenno

Index Scriptorium Estoniae

Tenno, Ann, 1952-

2003-01-01

Traditsioonilise maastikukoolkonna feng shui sümboliteks on roheline draakon, valge tiiger, must kilpkonn, punane fööniks. Taevased olendid tähistavad eelkõige maastikuvorme, nende abil võib tähistada olemasolevaid ehitisi ja struktuure, mis ümbritsevad meie kodu

Sae pekki! / Valner Valme

Index Scriptorium Estoniae

Valme, Valner, 1970-

2002-01-01

Meelelahutus- ja pilasaatest "Wremja" Kanal2-s (stsenaristid Andrus Kivirähk ja Mart Juur, näitlejad Dan Põldroos, Jan Uuspõld, Rednar Annus) pärit "rullnokad" ja nende prototüübid või epigoonid meie igapäeva-elus

Kas internet muudab meid rumalamaks? / Liis Kängsepp

Index Scriptorium Estoniae

Kängsepp, Liis, 1981-

2012-01-01

Raamatust: Carr, Nicholas. Triiv madalikule : mida Internet meie ajuga teeb / tõlkija Tiina Randus. Tallinn : Äripäev, 2012. (Äripäeva raamat). Ka intervjuu Tallinna Ülikooli dotsendi Kristjan Pordiga raamatus esitatud väidetest interneti mõjust inimesele

Eastwood kritiseerib sõjavaatemänge / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2007-01-01

Clint Eastwoodi kaks viimast filmi on Teises Maailmasõjas USA-Jaapani Iwo Jima saarel peetud ebavõrdse lahingu teemal. USA poolt vaadatuna - "Meie isade lipud" ("Flags of Our Fathers"), Jaapani poolt - "Kirjad Iwo Jimalt" ("Letters From Iwo Jima") : Ameerika Ühendriigid 2006

Eesti NATOga liitumiseks valmis / Lennart Meri ; intervjueerinud Ingvar Bärenklau

Index Scriptorium Estoniae

Meri, Lennart, 1929-2006

1995-01-01

President Lennart Meri kohtumine Saksamaa kaitseministri Volker Rühega, 23. august 1995. Ilmunud ka: Eesti Päevaleht (Stockholm), 31. aug., lk. 1, 2, pealk.: Kohtusid Lennart Meri ja Saksa kaitseminister: intervjuu Eesti presidendiga 24. augustil 1995; Meie Kodu, 13. sept., lk. 1.

Eestil läheb jätkuvalt hästi / Toomas Hendrik Ilves

Index Scriptorium Estoniae

Ilves, Toomas Hendrik, 1953-

2008-01-01

Vabariigi Presidendi tervitus Eesti rahvale 2007/2008. aastavahetusel Eesti Panga saalis. Ilmunud ka: Postimees 3. jaan. 2008, lk. 15, pealk.: Usalduse tugevnemise aasta; Postimees : na russkom jazõke 3. jaan. 2008, lk. 9; Eesti Päevaleht 3. jaanuar 2008, lk. 3, pealk.: Eestil läheb hästi; Maaleht 3. jaan. 2008, lk. 7, pealk.: Meie oleme õnnelik rahvas; Virumaa Teataja 3. jaanuar 2008, lk. 11, pealk.: Saame täna olla kindlamad kui kunagi varem; Pärnu Postimees 3. jaanuar 2008, lk. 15, pealk.: Armas Eesti rahvas kodus ja kaugel!; Lõunaleht 3. jaan. 2008, lk. 2, pealk.: Armas Eesti rahvas kodus ja kaugel!; Põhjarannik 3. jaan. 2008, lk. 4, pealk.: Armas Eesti rahvas kodus ja kaugel!; Severnoje Poberezhje 3. jaan. 2008, lk. 4; Meie Maa 3. jaan. 2008, lk. 2, pealk.: Vabariigi presidendi aastavahetuse tervitus; Hiiu Leht 4. jaan. 2008, lk. 2, pealk.: Presidendi tervitus; Harjumaa 4. jaan. 2008, lk. 2, pealk.: Armas Eesti rahvas kodus ja kaugel!; Eesti Päevaleht (Stockholm) 10. jaan. 2008, lk. 2; Eesti Elu 4. jaan. 2008, lk. 2, pealk.: Vabariigi Presidendi tervitus 2007/2008. aastavahetusel (lüh.); Vaba Eesti Sõna 3. jaan. 2008, lk. 3, pealk.: Vabariigi Presidendi tervitus 2007/2008. aastavahetusel, ingl. k. lk. 12, pealk.: President of the Republic New Year Address 2008; Meie Kodu 23. jaan. 2008, lk. 2, pealk.: Vabariigi Presidendi tervitus 2007/2008. aastavahetusel; Eesti Rada 2008, nr. 1, lk. 3, pealk.: Vabariigi Presidendi tervitus 2007/2008. aastavahetusel. Väljavõte tervitusest ilmunud ka: Postimees 31. dets. 2008, lk. 9, pealk.: President Toomas Hendrik Ilvese tervitus aastavahetusel 2007/2008

Politsei on tsiviilühiskonna lihased / Ignar Fjuk ; interv. Peep Lillemägi

Index Scriptorium Estoniae

Fjuk, Ignar, 1953-

2001-01-01

Ilmunud ka: Nädaline, 18. sept. 2001, lk. 6; Meie Maa, 18. sept. 2001, lk. 2; Virumaa Teataja, 20. sept. 2001, lk. 7; Valgamaalane, 20. sept. 2001, lk. 2; Vooremaa, 25. sept. 2001, lk. 2. Hinnang politseireformi sildi all toimunud koondamistele. Autor: Reformierakond. Parlamendisaadik

2004. aasta prognoos / Edda Paukson, Eduard Paukson

Index Scriptorium Estoniae

Paukson, Edda

2004-01-01

Vt. ka Järva Teataja, Põhjarannik : Laupäev ; Severnoje Poberezhje : Subbota, Virumaa Teataja, Võrumaa Teataja : Elu 3. jaan., Pärnu Postimees 6.,8. jaan., Harjumaa 6., 9.,13. jaan., Meie Maa : Oma Saar 10. jaan. Erinevatel lehekülgedel ja erinevate pealkirjade all

Minu isiklik poliitvang / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2006-01-01

Ilmunud ka: Infopress 18. aug. nr. 33 lk. 152-153. Valgevenes on elementaarse inimõiguse kasutamise eest vangi mõistetud kodanikuühenduse Partnerstva üks liidreid Mikalai Astrejka. Autori sõnul on vähim, mida meie teha saame, toetusallkirjade andmine Valgevene poliitvangide vabastamiseks

Gaz - almaz / Jekaterina Rodina

Index Scriptorium Estoniae

Rodina, Jekaterina

2008-01-01

Venemaa Energiapoliitika Instituudi arvutuste kohaselt võib maagaasi tootmise ja nõudluse vahe ulatuda 2010. aastaks 100 miljardi kuupmeetrini, Kui maagaasi tarned Eestisse ära jäävad, saab meie riik omal jõul hakkama kõige rohkem kuu aega. Vt. samas: Gaas arvudes

Lõbumaja uus perenaine / Janar Filippov, Tarmo Vahter

Index Scriptorium Estoniae

Filippov, Janar, 1976-

2004-01-01

Tallinnas asuva bordellina töötanud külalistemaja "Infant" uueks omanikuks sai Isamaaliidu Pärnu kontori juhataja, 70 firma omanik Ulrike Kahju, kes väidetavalt aitab firmasid juriidiliselt korrektselt likvideerida. Vt. samas intervjuud Ulrike Kahjuga; Milles meie süüdi oleme?

Õpikukuningas Jeffrey Sugerman : sa ei tohi hetkekski oma partnereid unarusse jätta / Jeffrey Sugerman

Index Scriptorium Estoniae

Sugerman, Jeffrey

2004-01-01

Juhtidele õppematerjale tootva suurfirma Inscape Publishing juht ettevõtte koostööst raamatuid edasimüüvate konsultatsiooni- ja koolitusfirmadega, juhtimisalase täiendõppe uuematest trendidest maailmas. Lisa: Inscape Publishing - meie tööpõhimõtted. Vt. samas: Inscape Balti riikides

Hiigeleksperiment pani teadlased juubeldama / Arko Olesk

Index Scriptorium Estoniae

Olesk, Arko, 1981-

2008-01-01

Vt. ka Postimees : na russkom jazõke. 11. sept., lk. 7. Euroopa Tuumauuringute Organisatsiooni (CERN) füüsikaeksperimendist LHC, mis toob eeldatavalt revolutsiooni nii meie arusaamisele elementaarosakestest ja Universumi tekkest kui paneb aluse uue põlvkonna internetile. Lisaks skeem: Suure paugu päev

Nõukogude arhitektuuripärandi nostalgia ja tulevik = Nostalgia and the future of soviet architecture's heritage / Triin Ojari

Index Scriptorium Estoniae

Ojari, Triin, 1974-

2012-01-01

Nostalgilisest ja operatiivsest lähenemisest nõukogude aja ehitusliku pärandiga suhestumisel. Autori sõnul on majade üks olulisi väärtusi nende lugudes, mis omakorda mõjutab nende kasutusväärtust, tulevikku ja meie suhet oma ümbrusesse

Tuumavägi ja turvaline ühiskond / Tiit Kändler

Index Scriptorium Estoniae

Kändler, Tiit, 1948-

2011-01-01

Autori sõnul ei saa ta aru, kuidas tuumakütuse sisseostmine võiks suurendada meie energiasõltumatust või turvalisust. Võib-olla oleks Eestil parem paigutada raha kodanike turvalisuse ja mugavuse valdkonda ning kasutada ja täiendada oma põlevkivi kasutamise oskust

Eesti kui Belgia : viimane baltlane Hermann Keyserling / Jaan Undusk

Index Scriptorium Estoniae

Undusk, Jaan, 1958-

2003-01-01

H. Keyserlingi (1880-1946) "Balti filosoofia" käsitlusest, belgiseerimise plaanist ning Baltikumist kui multikulturalismi taimelavast. Lisad: "Balti küsimus", "Eesti poliitiline tähendus. Suhtumine bolshevismi", "Balti ühisrinne", "Vastus krahv Hermann Keyserlingile tema Balti ühisrinde asjus", "Meie baltlased" lk. 71-78

Prantsusmaal ilmus kolm eesti kirjandusteost

Index Scriptorium Estoniae

2002-01-01

Antoine Chalvini tõlgitud novellikogu "Les hirondelles" ("Pääsukesed") sisaldab 19 eesti kirjaniku novelle. Eva Koffi näidendi "Meie isa" tõlkis Eva Toulouze. Prantsuse keeles ilmus ka Jaan Kaplinski luulekogu "Le désir de la poussière" ("Tolmu igatsus")

70 aastat järvelinna filmilindilt vaadatuna

Index Scriptorium Estoniae

2008-01-01

Juubelit tähistav Viljandi sai kaks reklaamfilmi : "Euroopa suurepärased turismikohad, meie varjatud aarded" ja "Pärimuse katel Viljandis". Ka varem valminud vaatefilmidest "Viljandimaa Ancient Beat" (2006) ja "Järvelinn Viljandi" (1983). Sissejuhattus teemasse, Gert Kiileri repliik "Filmid ühte kokku!" lk. 2

DIMENSIUNI EXPERIMENTALE ALE NIVELULUI DE PREGĂTIRE, FORMARE A CADRELOR DIDACTICE PENTRU IMPLICARE ÎN ACTIVITĂŢILE DE RECUPERARE A COPIILOR CU DEFICIENŢE MINTALE

Directory of Open Access Journals (Sweden)

Oleg ABABII

2016-12-01

Full Text Available Recuperarea prin educaţie a copiilor cu deficienţe mintale, inclusiv severe, poate înregistra eficienţă înaltă, dacă vor fi corect selectate şi formate cadrele didactice. Rezultatele implementării formării organizate a resurselor umane în problema recuperării sunt demonstrate prin schimbarea pozitivă a multor criterii de evaluare: o creştere a coeficientului intelectual, profesorii au devenit mult mai răbdători, mai încrezuţi în ceea ce fac, urmăresc acţiunile dar şi retrăirile copiilor, sunt mult mai sensibili, sinceri cu cei din jur, nu permit conflictele şi găsesc soluţii de compromis, majoritatea sunt motivaţi la succes, au devenit mai toleranţi, a diminuat agresivitatea, s-au redus atitudinile rigide, au crescut atitu­dinile comunicative şi organizatorice, a devenit populară colaborarea şi relaţia prietenoasă cu colegii, majoritatea resur­selor umane (100% au un comportament flexibil, vin în susţinerea copiilor pe parcursul tuturor acţiunilor recuperatorii, sunt mândri de rezultatele realizate în CPPC „Orfeu”. Pentru verificarea nivelului de dezvoltare a acestor formaţiuni la cadrele didactice selectate pentru activitatea cu copiii cu deficienţe mintale, inclusiv severe, a fost efectuată o eşantionare simplă după principiul aliator. Eşantionul este constituit din 32 de cadre didactice, care au fost supuse testării pentru activitatea în Complexul-Pilot de Pedagogie Curativă „Orfeu”. A fost descris impactul creşterii nivelului de profesiona­lism al cadrelor didactice în urma formării specializate asupra eficientizării calităţii recuperării copiilor cu DM, inclusiv severe.EXPERIMENTAL DIMENSIONS OF THE LEVEL OF EDUCATION, TEACHER TRAINING FOR INVOLVEMENT IN THE RECOVERY OF CHILDREN WITH MENTAL DISABILITIESRecovery through education of children with mental disabilities, including severe high efficiency can register, if they are properly selected and formed teachers. Results

Radioaerosol Inhalation Imaging in Bronchial Asthma

International Nuclear Information System (INIS)

Kim, Bum Soo; Park, Young Ha; Park, Jeong Mi; Chung, Myung Hee; Chung, Soo Kyo; Shinn, Kyung Sub; Bahk, Yong Whee

1991-01-01

Radioaerosol inhalation imaging (RII) has been used in radionuclide pulmonary studies for the past 20 years. The method is well accepted for assessing regional ventilation because of its usefulness, easy fabrication and simple application system. To evaluate its clinical utility in the study of impaired regional ventilation in bronchial asthma, we obtained and analysed RIIs in 31 patients (16 women and 15 men; age ranging 21-76 years) with typical bronchial asthma at the Department of Radiology, Kangnam St. Mary's Hospital, Catholic University Medical college, from January, 1988 to August, 1989. Scintiscans were obtained with radioaerosol produced by a HARC(Bhabha Atomic Research Center, India) nebulizer with 15 mCi of 99m Tc-phytate. The scanning was performed in anterior, posterior and lateral projections following 5-minute inhalation of radioaerosol on sitting position. The scans were analysed and correlated with the results of pulmonary function study and the findings of chest radiography. Fifteen patients had concomitant lung perfusion image with 99m Tc-MAA. Follow-up scans were obtained in 5 patients after bronchodilator therapy. 1 he patients were divided into (1) attack type (4 patients), (2) resistant type (5 patients), (3) remittent type (10 patients) and (4) bronchitic type (12 patients). Chest radiography showed hyperinflation, altered pulmonary vascularity, thickening of the bronchial wall and accentuation of hasal interstitial markings in 26 of the 31 patients. Chest radiographs were normal in the remaining 5 patients. Regardless of type, the findings of RII were basically the same, and characterized by the deposition of radioaerosol in the central parts or in the main respiratory air ways along with mottled nonsegmental ventilation defects in the periphery. Peripheral parenchymal defects were more extensive than that of expected findings from clinical symptoms, pulmonary function test and chest radiograph. Broomstick sign was present in 1.7 patients

An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling

Energy Technology Data Exchange (ETDEWEB)

Kim, Sun Kyung; Barron, Lindsey; Hinck, Cynthia S.; Petrunak, Elyse M.; Cano, Kristin E.; Thangirala, Avinash; Iskra, Brian; Brothers, Molly; Vonberg, Machell; Leal, Belinda; Richter, Blair; Kodali, Ravindra; Taylor, Alexander B.; Du, Shoucheng; Barnes, Christopher O.; Sulea, Traian; Calero, Guillermo; Hart, P. John; Hart, Matthew J.; Demeler, Borries; Hinck, Andrew P. (Texas-HSC); (NRCC); (Pitt)

2017-02-22

The transforming growth factor β isoforms, TGF-β1, -β2, and -β3, are small secreted homodimeric signaling proteins with essential roles in regulating the adaptive immune system and maintaining the extracellular matrix. However, dysregulation of the TGF-β pathway is responsible for promoting the progression of several human diseases, including cancer and fibrosis. Despite the known importance of TGF-βs in promoting disease progression, no inhibitors have been approved for use in humans. Herein, we describe an engineered TGF-β monomer, lacking the heel helix, a structural motif essential for binding the TGF-β type I receptor (TβRI) but dispensable for binding the other receptor required for TGF-β signaling, the TGF-β type II receptor (TβRII), as an alternative therapeutic modality for blocking TGF-β signaling in humans. As shown through binding studies and crystallography, the engineered monomer retained the same overall structure of native TGF-β monomers and bound TβRII in an identical manner. Cell-based luciferase assays showed that the engineered monomer functioned as a dominant negative to inhibit TGF-β signaling with a Ki of 20–70 nM. Investigation of the mechanism showed that the high affinity of the engineered monomer for TβRII, coupled with its reduced ability to non-covalently dimerize and its inability to bind and recruit TβRI, enabled it to bind endogenous TβRII but prevented it from binding and recruiting TβRI to form a signaling complex. Such engineered monomers provide a new avenue to probe and manipulate TGF-β signaling and may inform similar modifications of other TGF-β family members.

Ethnic disparities in educational and occupational gradients of estimated cardiovascular disease risk: The Healthy Life in an Urban Setting study.

Science.gov (United States)

Perini, Wilco; Agyemang, Charles; Snijder, Marieke B; Peters, Ron J G; Kunst, Anton E

2018-03-01

European societies are becoming increasingly ethnically diverse. This may have important implications for socio-economic inequalities in health due to the often disadvantaged position of ethnic minority groups in both socio-economic status (SES) and disease, especially cardiovascular disease (CVD). The aim of this study was to determine whether the socio-economic gradient of estimated CVD risk differs between ethnic groups. Using the Healthy Life in an Urban Setting study, we obtained data on SES and CVD risk factors among participants from six ethnic backgrounds residing in Amsterdam. SES was measured using educational level and occupational level. CVD risk was estimated based on the occurrence of CVD risk factors using the Dutch version of the systematic coronary risk evaluation algorithm. Ethnic disparities in socio-economic gradients for estimated CVD risk were determined using the relative index of inequality (RII). Among Dutch-origin men, the RII for estimated CVD risk according to educational level was 6.15% (95% confidence interval [CI] 4.35-7.96%), indicating that those at the bottom of the educational hierarchy had a 6.15% higher estimated CVD risk relative than those at the top. Among Dutch-origin women, the RII was 4.49% (CI 2.45-6.52%). The RII was lower among ethnic minority groups, ranging from 0.83% to 3.13% among men and -0.29% to 5.12% among women, indicating weaker associations among these groups. Results were similar based on occupational level. Ethnic background needs to be considered in associations between SES and disease. The predictive value of SES varies between ethnic groups and may be quite poor for some groups.

Töötajate usaldusisikute positsioon peab paranema / Kadi Pärnits

Index Scriptorium Estoniae

Pärnits, Kadi, 1965-

2005-01-01

Töötajate usaldusisiku seaduse muutmise seaduse eelnõust. Sama ka Hiiu Leht 18. veeb. 2005, lk. 2 ; Meie Maa 22. veeb. 2005, lk. 2 ; Valgamaalane 10. märts 2005, lk. 2 ; Koit 5. veeb. 2005, lk. 6, artiklis pealkiri kujul: usaldusisiku seisund peab paranema

Eesti arvutikunsti teke = The birth of Estonian computer art / Tuuli Lepik

Index Scriptorium Estoniae

Lepik, Tuuli

2010-01-01

Arvutustehnika arengust, esimestest elektronarvutitest Eestis ja kunstiväliselt loodud visuaalidest, s.t. tähemärkidest piltidest meie teadusasutustes, esimestest kunstnikest, kes kasutasid arvutigraafikat pildi loomiseks, Fin Plotteri tegevusest, inseneride, programmeerijate, informaatikute ja kunstnike koostööst, ka Eestis loodud arvutimängudest

Sõbralik fašism, inimnäoline rassism ja teised Eesti asjad / Johannes Saar

Index Scriptorium Estoniae

Saar, Johannes, 1965-

2007-01-01

Kriitika politoloog Samuel Huntingtoni kultuurifilosoofia aadressil, millele autori arvates toetub Eesti välispoliitiline strateegia. Kui selline filosoofia on osa meie ametlikust välispoliitilisest doktriinist, siis paistabki Eesti välismaailmale natsimeelsena, väidab autor. S. Huntingtoni on korduvalt tsiteerinud ka Toomas Hendrik Ilves

Aasta tegu teadus- ja erialaraamatukogus / Ave Janu

Index Scriptorium Estoniae

Janu, Ave

2010-01-01

Teadusraamatukogu aasta teoks 2008 tunnistati RR-i virtuaalnäitus "Meie parlament ja aeg: fakte, sündmusi, dokumente, inimesi". Erialaraamatukogu aasta teo 2008 vääriliseks tunnistati nägemispuudega lugejatele heliteavikute automatiseeritud paljundamise ja posti teel laenutamise süsteem Eesti Pimedate Raamatukogus

"Seinte vahel" - klišeevaba film koolist / Inge Unt

Index Scriptorium Estoniae

Unt, Inge, 1928-

2009-01-01

Prantsusmaa 2008. a. mängufilmist "Seinte vahel" ("Entre les murs"), mille stsenarist oma romaani alusel ning peaosa täitja on Francois Begaudeau, režissöör Laurent Cantet. Filmist, mille kaudu saab teada, kuidas toimib meie põhikooli vanemale astmele vastav prantsuse kool

Ettevõtte tulumaks tuleb taastada! / Rene Tammist

Index Scriptorium Estoniae

Tammist, Rene, 1978-

2002-01-01

Ilmunud ka: Hiiu Leht 24. mai lk. 2, Meie Maa 25. mai lk. 2, Koit 30. mai lk. 6, Voorema 6. juuni lk. 3, Sakala 7. juuni lk. 2, Valgamaalane 22. juuni lk. 2. Hiljemalt jaanuariks 2004 tuleb ettevõtte kasum maksustada vähemalt 18% ulatuses

Inimkonna ainuke võimalus on taastuvate ressursside kasutamine / Taito Mikkonen

Index Scriptorium Estoniae

Mikkonen, Taito

2006-01-01

Enam ei ole aega vaielda, kas tuumajõud või põlevkivi. Energeetika probleemiks pole ainult energia kättesaadavus ja hind, vaid lisaks keskkonnakaitsele terve maailma elukeskkonna säilitamine. Lahendused nõuavad muudatusi mõtlemise alustes ning mõjutavad meie eluviisi, poliitikat ja moraali

Natura 2000 kütab kirgi / Jüri Saar

Index Scriptorium Estoniae

Saar, Jüri, 1946-

2005-01-01

Ilmunud ka: Meie Maa 26. spr., lk. 2. Riigikogu keskkonnakomisjoni aseesimehe sõnul viib valitsusliit looduse mitmekesisuse säilitamiseks lõpule Natura 2000 võrgustiku alade kaitse alla võtmise, jätkab loodushoiu toetuste maksmist pärandkooslusel ja alustab toetuste maksmist Natura aladel

Ilmus uus CD Arvo Pärdi muusikaga, esitajaks eestlased

Index Scriptorium Estoniae

2004-01-01

heliplaadi "Pro & contra" andis välja Virgin Classics, Eesti Riiklik Sümfooniaorkester Paavo Järvi dirigeerimisel esitab seal järgmised A. Pärdi teosed - "Meie aed", 1. ja 2. sümfoonia, "Pro & contra", "Kollaaž teemal B-A-C-H" ja "Perpetum mobile"

Aivar Sõerd: Estonija na fone drugihh tshlenov JeS brossajetsja v glaza! / Aivar Sõerd ; interv. Jekaterina Rodina

Index Scriptorium Estoniae

Sõerd, Aivar, 1964-

2007-01-01

Rahandusminister Aivar Sõerd vastab küsimustele, mis muu hulgas puudutavad arengufondi, ülejäägiga riigieelarvet, euro kasutuselevõtu edasilükkumist, A. Sõerdi nimetamist parimaks ministriks rahandusaastal, samuti ministri hobisid. Minister peab meie probleemiks, et pole suudetud parimal viisil kasutada EL-i fondide vahendeid

Lennuk Tartu kohal pani aluse esimesele Eesti filmistuudiole / Jaan Ruus

Index Scriptorium Estoniae

Ruus, Jaan, 1938-2017

2005-01-01

Johannes Pääsukese (1892-1918) "Utotškini lendamised Tartu kohal 14. ja 15. aprillil 1912", mis on seni teadaolevalt esimene eestlase filmitud kroonikapala. Lisatud tabelid "Esimene film" ja "Meie naabrite esimesed", mis toovad ära aastad, mil maailma eri riikides sündis esimene kinofilm

Iharus iseenda järele / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2006-01-01

Tutvustus: Gide, André. Surra, et elada / tlk. Leena Tomasberg. Tallinn : Varrak, 2006 ; Soosaar, Martti. Lase vareseid! Tallinn : Tänapäev, 2006 ; Otsides : Juhan Peegel. Meenutusi pikalt teelt / koost. Maarja Lõhmus. Tallinn : Tänapäev, 2006 ; Steffenson, Jakob. Meie, ruhnlased. Tartu : A. Tuulberg, 2006

"Sinjaja ptitsa" - shedevr stoletnei võderzhki / Anatoli Korolev

Index Scriptorium Estoniae

Korolev, Anatoli

2008-01-01

Moskva Kunstiteater tähistab Maurice Maeterlincki näidendi "Sinilind" lavastuse 100. juubelit. Esmalavastus Moskva Kunstiteatris 1908, lavastaja Konstantin Stanislavski. "Sinilind" on vene reformaatori ainus lavastus, mis on säilinud meie päevini. Praegu mängitakse seda Gorki-nim. Kunstiteatris Tatjana Doronina lavastuses

Bibliotecile în societatea contemporană – provocări, mutaţii, perspective în context digital

Directory of Open Access Journals (Sweden)

Elena Tîrziman

2009-01-01

Full Text Available În societatea contemporană, bibliotecile sunt o componenta activă a procesului de achiziţionare, prelucrare, comunicare, utilizare, conservare şi arhivare a resurselor informaţionale şi documentare. Pentru a-şi îndeplini menirea sunt obligate să răspundă provocărilor mediului electronic integrându-se noului context informaţional şi de comunicare. Sunt vizibile o serie de mutaţii care se produc la nivelul bibliotecii ca structură de informare şi documentare, la nivelul proceselor biblioteconomice şi a produselor şi serviciilor oferite, la nivelul profesiilor din domeniul ştiinţelor informării şi comunicării, la nivelul utilizatorului şi a nevoilor sale de informare. Asistăm astfel la transformarea bibliotecilor din biblioteci tradiţionale în biblioteci hybrid şi biblioteci cu importante colecţii digitale devenind instituţii manageri ai informaţiei şi cunoaşterii care îşi desfăşoară activităţile într-un nou context dominat de Tehnologiile Informaţiei şi Comunicării.

FORMAREA CULTURII RELAŢIILOR INTERGENERAŢIONALE ABORDATĂ ÎN CONTEXTUL PSIHOLOGIEI ŞI PEDAGOGIEI COMUNITĂŢII

Directory of Open Access Journals (Sweden)

Carolina CALARAŞ

2016-12-01

Full Text Available În cele ce urmează prezentăm un studiu teoretic cu implicaţii practice vizavi de formarea culturii relaţiilor inter­ge­ne­ra­ţionale. Relaţiile integeneraţionale au fost analizate şi conceptualizate în contextul teoriilor de bază ale psihologiei comunităţii. În corelaţie cu acestea au fost configurate Schema ecologiei dezvoltării umane şi principiile.Cuvinte-cheie: relaţii intergeneraţionale, cultura relaţiilor intergeneraţionale, psihologia şi pedagogia comunităţii, teoria câmpului, cercetare-acţiune, teoria dimensionării relative, perspectiva ecologică a dezvoltării umane. FORMATION OF CULTURAL INTERGENERATIONAL RELATIONS IN THE CONTEXT OF PSYCHOLOGY AND PEDAGOGY COMMUNITYThis article represents a theoretical study with practical implications about formation a culture intergenerational relationships. Integenerational relationships were analyzed and conceptualized in the context of the basic theories of psychology community. In conjunction with this there have been set Ecology of human development scheme and principles.

Efficacy of sulfadoxine-pyrimethamine and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon basin of Peru Eficácia da sulfadoxina-pirimetamina e mefloquina no tratamento de malária não-complicada por Plasmodium falciparum na bacia amazônica peruana

Directory of Open Access Journals (Sweden)

Alan J. Magill

2004-06-01

Full Text Available In vivo antimalarial drug efficacy studies of uncomplicated Plasmodium falciparum malaria at an isolated site in the Amazon basin of Peru bordering Brazil and Colombia showed >50% RII/RIII resistance to sulfadoxine-pyrimethamine but no evidence of resistance to mefloquine.Testes in vivo foram realizados para avaliar resistência a drogas antimalária, em pessoas com malária não complicada, causada por Plasmodium falciparum, numa região isolada da Bacia Amazônica, na fronteira com o Brasil e a Colômbia. Os testes mostraram resistência >50% RII/RIII a sulfadoxina-pirimetamina, mas não evidenciaram resistência a mefloquina.

Elutuba keset kaubamaju : Eesti Kunstiakadeemia uus hoone / Triin Ojari

Index Scriptorium Estoniae

Ojari, Triin, 1974-

2008-01-01

Eesti Kunstiakadeemia uue hoone arhitektuurikonkursist, žürii koosseis, väljavõtted žürii lõppraportist. I preemia - "Art Plaza", SEA: Uffe Leth Laursen, Karsten Gori + EFFEKT: Tue Hesselberg Foged, Sinus Lynge (Taani), kaasa töötasid Greta Tedje, Simon Sorensen, Lawrence Aeberhard, Lyndal Brown, Morgan Jacobsen. II preemia - "TLN 247", NAT Architecten (Holland): Frank van Manen, Metin van Zijl, Vincent van der Klei, Tjalf van Dijkhuizen, Suzanna van der Meer, Daniel Aw, Bobby de Graaf, John Kuilman, Niels Limburg. III preemia - "Arts Factory", NERALP-Arquitectura Engenharia e Construcoes LDA (Portugal): Paulo Sergio Goncalves Teixeira de Sousa. Kommenteerib võistluse tingimused koostanud arhitekt Tiit Sild

Meie pühitsetud lipp / Peeter Laurits

Index Scriptorium Estoniae

Laurits, Peeter, 1962-

2006-01-01

Mel Gibsoni mängufilm "Kristuse kannatused" ("The Passion of the Christ") : Ameerika Ühendriigid 2004. Selle filmi näitel esitab kunstnik oma vaatekoha kristliku kiriku moraali, eetika ja poliitika kohta, kaheldava õiguse kohta õpetada eesti koolis usuõpetust. Sama artikkel ka kogumikus "Esseed. Ajalehes Postimees ilmunud esseed 2005-2007", Postimees 2007, lk. 59-63 : ill

Inimesed meie ümber / Anne-Ly Sova

Index Scriptorium Estoniae

Sova, Anne-Ly, 1976-

2007-01-01

Münchenis toimunud teatrifestivali "Spielart" mõnest etendusest: Stefan Kaegi ja Lola Ariase dokumentaallavastus "SOKO Sao Paulo", Tim Etchellsi ja Belgia trupi Victoria "That Night Follows Day", Alvis Hermanise "Väter"

Nii nad tapsidki meie Ferdinandi / Hannes Rumm

Index Scriptorium Estoniae

Rumm, Hannes, 1968-

2007-01-01

Allar Jõks ei jätka õiguskantslerina. Ilmunud ka Virumaa Teataja 20. dets. 2007, lk. 11 ; Järva Teataja 20. dets. 2007, lk. 2 ; Sakala 21. dets. 2007, lk. 2 ; Põhjarannik 20. dets. 2007, lk. 2 ; Vooremaa 20. dets. 2007, lk. 2 ; Lääne Elu 20. dets. 2007, lk. 2 ; Nädaline 20. dets. 2007, lk. 4 ; Hiiu Leht 28. dets. 2007, lk. 2 ; Pärnu Postimees 9. jaan. 2008, lk. 15 ; Nädalaleht 21. dets. 2007, lk. 4

Filme meist ja meie ajast / Raimo Jõerand

Index Scriptorium Estoniae

Jõerand, Raimo

2007-01-01

EFSA filmiekspert teavitab uutest eesti tõsielufilmidest : Urmas E. Liivi "Casting" ja "Briljantroheline maja, pumbakaev ja valge laev", Andres Maimiku, Jaak Kilmi "Müümise kunst", James ja Maureen Tusty "Laulev revolutsioon"

Meie igapäevane paanika / Ott Karulin

Index Scriptorium Estoniae

Karulin, Ott, 1980-

2007-01-01

Kahest Vanemuise teatri lavastusest Tartus - Saksa Kultuuri Instituudis etendunud Ingvar Ambjornseni-Axel Hellsteniuse "Elling" Ain Mäeotsa lavastuses ja Laura Cunninghami "Beautiful Bodies" Vanemuises, lavastaja Jüri Lumiste

Naisfotograafid, kes avavad meie silmad / Katie Breen

Index Scriptorium Estoniae

Breen, Katie

2008-01-01

Fotograafid Ami Vitale, Helene David, Stephanie Sinclair, Lauren Greenfield, Deirdre Brennan, Veronique de Viguerie, Christine Spengler pildistavad võõraid kultuure Aafrikas, Alaskal, Afganistanis, Iraagis. 9 fotot. Portreefotod fotograafidest

Koletised meie sees / Alar Niineväli

Index Scriptorium Estoniae

Niineväli, Alar

2004-01-01

Tallinna VIII Pimedate Ööde Filmifestivali filme - filmisari "Kolm... Äärmused" ("Three... Extremes") kui Aasia horrori antoloogia : Hongkongi režissööri Fruit Chani "Ravioolid" ("Ravioli") ; Lõuna-Korea režissööri Park Chan-wooki "Sisselõige" ("Cut") ; Jaapani režissööri Takashi Miike "Kast"

Teie ajalugu on meie ajalugu / Franco Frattini

Index Scriptorium Estoniae

Frattini, Franco

2005-01-01

Artikkel põhineb Euroopa Komisjoni asepresidendi avalikul vastuskirjal Euroopa Parlamendi liikmete Vytautas Landsbergise ja Joszef Szajeri varasemale üleskutsele suhtuda kommunistlikesse sümbolitesse sama rangelt kui natsisümbolitesse

Milline on meie vaimu seis / Mati Sirkel

Index Scriptorium Estoniae

Sirkel, Mati

2002-01-01

Eesti kirjanike ja kirjanduse kajastamisest meedias. Vastukajad: Raudnask, Valve. Mula nagu muda // Postimees (2002) 22. okt., lk. 12 (Kirjad); Kender, Kaur. Tüütu ja tülikas armastus // Postimees (2002) 28. okt., lk. 13 (Arvamus); Kadastik, Mart. Kenderi seadus - avameelselt armastusest // Postimees (2002) 30. okt., lk. 13; Berg, Maimu. Geniaalsuse asemel nahaalsus //Postimees (2002) 2. nov., lk. 9

Meie oma Aarete saar : [arvustus] / Enn Nõu

Index Scriptorium Estoniae

Nõu, Enn, 1933-

2012-01-01

Arvustus: Mats Burström. Minnesgömmor: berättelser om föremål gömda i jorden i Estland under andra världskriget. Lund: Nordic Academic Press, 2012 ; Burström, Mats. Treasured Memories: Tales of Buried Belonings in Wartime Estonia. Lund: Nordic Academic Press, 2012

Meie aja kangelane / Mare Müürsepp

Index Scriptorium Estoniae

Müürsepp, Mare

2001-01-01

Lasteraamatust kui kasvatuse faktorist. Uuringust, milles vaadeldi lapstegelaste kujutamist 1991-2000.a. ilmunud Eesti algupärases lastekirjanduses. Kirjandustegelasi on analüüsitud järgmistest aspektidest lähtudes: vanus, sugu, perekondlik taust, individuaalsus-kollektiivsus, probleemid, inimideaalid

Hüpped modernismi poole II : 20. sajandi eesti kirjandusteadus Euroopa kirjandusteaduse taustal. 4. loeng : Eesti kirjandus ja selle uurimine 19. sajandil : romantilise idealismi aeg / Tiit Hennoste

Index Scriptorium Estoniae

Hennoste, Tiit, 1953-

2006-01-01

Ka eesti 19. sajandi kirjanduslugudest: Dietrich Heinrich Jürgensoni "Kurze Geschichte der ehstnischen Literatur" (1843-44), August Ahlqvisti "Viron nykyisemmästä kirjallisuudesta" (1855), Karl August Hermanni "Eesti kirjanduse ajalugu esimesest algusest meie ajani" (1898) ja Tõnu Sanderi "Eesti kirjanduse ajalugu" (1. osa 1899, 2. osa 1901)

Riigieelarve eesmärgid / Eugen Veges

Index Scriptorium Estoniae

Veges, Eugen, 1955-

2008-01-01

Ilmunud ka: Põhjarannik, Meie Maa 3. sept. lk. 2, Severnoje Poberezhje 4. sept., lk. 2, Koit 4. sept. lk. 6, Harju Ekspress 5. sept. lk. 6, Võrumaa Teataja 6. sept. lk. 2, Vooremaa 11. sept., lk. 2, Lõunaleht 11. sept. lk. 4. Autori nägemus riigi eelarvepoliitika kujundamisest

Narr kui ajastu metafoor / Kärt Hellerma

Index Scriptorium Estoniae

Hellerma, Kärt, 1956-

2001-01-01

William Shakespeare'i "Kuningas Lear" (lav. Priit Pedajas) ja Pedro Calder̤n de la Barca "Elu on unenägu" (lav. Ingo Normet) Eesti Draamateatris. Ilmunud ka kogumikus : Hellerma, Kärt. Avanenud ruum. Tallinn : Eesti Keele Sihtasutus, 2006, lk. 213-216. Pealk. Narr kui meie aja kangelane

Mineviku pantvangid / Vootele Hansen

Index Scriptorium Estoniae

Hansen, Vootele, 1962-

2001-01-01

Kommunistliku režiimi kuritegelikkusest. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik. Ilmunud ka: Severnoje Poberezhje, 16. juuni 2001, lk. 2; Meie Maa, 16. juuni 2001, lk. 2; Võrumaa Teataja, 19. juuni 2001, lk. 2; Sakala, 20. juuni 2001, lk. 2; Lääne Elu, 19. juuni 2001, lk. 4

Kak zamutit problemu pensii / Janno Reiljan

Index Scriptorium Estoniae

Reiljan, Janno, 1951-2018

2001-01-01

Vanaduspension peab olema tulu väljatöötatud aastate eest. Autor: ERL. Parlamendisaadik. Ilmunud ka: Põhjarannik, 12. apr. 2001, lk. 2; Severnoje Poberezhje, 12. apr. 2001, lk. 2; Koit, 12. apr. 2001, lk. 6; Meie Maa, 12. apr. 2001, lk. 2; Valgamaalane, 17. apr. 2001, lk. 2

Mida tulevikuga peale hakata? / Arko Olesk

Index Scriptorium Estoniae

Olesk, Arko, 1981-

2014-01-01

Arvustus: Kaku, Michio. Tulevikufüüsika : kuidas teadus aastal 2100 kujundab inimsaatust ja meie igapäevast elu / tlk. Arko Olesk. Tallinn : Pilgrim, 2013 ; Stevenson, Mark. Optimisti teekond tulevikku : üks uudishimulik sell tahab teada: mis saab edasi? / tlk. Vahur Lokk. Tallinn : Äripäev, 2013

Boikott või võidurelvastumine / Jürgen Ligi

Index Scriptorium Estoniae

Ligi, Jürgen, 1959-

2008-01-01

Ilmunud ka: Meie Maa 23. aug., lk. 2. Molodjozh Estonii 26. aug. lk. 6. Parlamendiliikme hinnangul peaks Eesti näitama oma suhtumist Venemaasse ning toetab Eurovisiooni boikoteerimist Moskvas. Artikkel pärineb Jürgen Ligi veebipäevikust http://ww.reform.ee/kandidaat/jyrgenligi/blogi&category_id=89

Põllumajandustehnikat uuenda aegsasti / Anita Hoole

Index Scriptorium Estoniae

Hoole, Anita

2006-01-01

Ilmunud ka: Võrumaa Teataja 13. apr. lk. 5. Kagu-Eesti regiooni liisinguhalduri sõnul ei ole põllumehed veel teadvustanud, millised on võimalused kasutada nii Euroopa Liidu fondide vahendeid, aga ka Eestist kättesaadavat ressurssi, mida annavad meie finantsasutused maapiirkondadele laenude ja liisingute näol

Ingli ja kuradi laps : moekollektsioon 'Est' sõidab Eestit esindama Berliini / Tiina Jõgeda

Index Scriptorium Estoniae

Jõgeda, Tiina, 1962-

1998-01-01

Moetudeng Aldo Järvsoost, kes on paar aastat võitnud moekonkursi 'IN-show'. Aasta alguses sai aasta moedisaineri tiitli ehk 'Kuldse nõela' omanikuks, võitis aprillis moetudengite konkursi Smirnoff Fashion Awardsi Eesti eelvooru ning sõidab juulis oma kollektsiooniga Berliini. A. Järvsoo endast, meie rõivapoodidest.

Kui palju toodab õpilane kooliteel CO₂? / Daisy Kärner

Index Scriptorium Estoniae

Kärner, Daisy

2010-01-01

Euroopa Liidu toetatud säästva arengu programm "SUPPORT" kuulutas möödunud kevadel välja kampaania "CO₂ - meie kooliteel", mille eesmärk oli teadvustada inimmõju kliima soojenemisele. Koole osales kogu Euraasiast. Parima uurimistöö tegi Pärnu-Jaagupi gümnaasium

Takku - connecting people / Tommi Mäkynen

Index Scriptorium Estoniae

Mäkynen, Tommi

2004-01-01

"Takku" on osa T. Mäkyneni Helsingi Tehnikaülikoolis tehtud väitekirjaprojektist "Helsinki + 22, ei loskaa". Projekti eesmärgiks on linna kompaktsemaks muutmine, arendades Helsingi kesklinna. "Takku" toob välja, kuidas globaalsed nähtused, jõud ja protsessid avaldavad meie argikeskkonnale lokaalset mõju

В Лос-Анджелесе на вручении телепремии "Эмми" "Безумцы" повторили свой успех

Index Scriptorium Estoniae

2010-01-01

29. augustil anti Los-Angeles'is üle järjekordsed teleauhinnad tseremoonial The 62nd Primetime Emmy Awards. Parima draamaseriaali Emmy võitis "Mad Men". Eesti telekanalite programmijuhtide kommentaarid ja info sellest, milliseid populaarseid USA seriaale võib meie televaataja näha. Lisatud võitjate nimekiri

Kalevite kange rahvas / Valter Lang

Index Scriptorium Estoniae

Lang, Valter, 1958-

2012-01-01

Autor uurib, kuidas võidi kutsuda sotsiaalselt paremal järjel olevaid inimesi muinasajal, juhtides tähelepanu ühele võimalusele omakeelse ülikunime väljaselgitamisel - selleks võiks olla meie rahvaluule vägilane Kalev. Pöördutakse nii rahvaluule, keeleajaloo kui ka arheoloogia poole

Et ainult inimene mõtleb? Ajab rotigi naerma! / Mati Soomre

Index Scriptorium Estoniae

Soomre, Mati, 1944-2015

2008-01-01

USA Bowling Green State'i ülikooli emeriitprofessor, Tartu Ülikooli audoktor professor Jaak Panksepp väidab, et rotid naeravad ning USA Georgia Ülikooli teadlased Allison Foote ja Jonathon Crystal leidsid, et ka rotil on metakognitsioon - võime oma mõtlemist mõelda. Vt. ka lk. 35: Rott & meie

Perekond Paukson ennustab : aasta 2005 - keerulisem, raskem ja segaduste rohkem / Edda Paukson, Eduard Paukson

Index Scriptorium Estoniae

Paukson, Edda

2005-01-01

Järgneb 8. jaan. Vt. ka SL Õhtuleht 3. jaan., Võrumaa Teataja 4. jaan., Virumaa Teataja 6. jaan., Harjumaa 7.,14. jaan., Järva Teataja, Meie Maa : Oma Saar, Pärnu Postimees 8. jaan., Harjumaa 11. jaan., Sakala 18.,20.,21. jaan. Erinevatel lehekülgedel ja erinevate pealkirjade all

Al-Zarqawi - terrorist või kangelane? / Kalev Kask

Index Scriptorium Estoniae

Kask, Kalev

2005-01-01

Ilmunud ka: Meie Maa 29. juuni lk. 5. Jordaanias sündinud palestiinlane Abu Musab al-Zarqawi, õige nimega Ahmed Fadel al-Khalaylah, on rühmituse Jama'at al-Tawhid wal Jihad juht ja hetkel kuulsaim sõjapealik Iraagis, kes on pühendanud oma elu võitlusele USA vastu

Kas üksiku ülikooli või Eesti huvid? / Ene Grauberg, Peeter Kreitzberg

Index Scriptorium Estoniae

Grauberg, Ene, 1944-

2006-01-01

Autorid peavad meie kõrghariduse ja teaduse arengu probleemiks, et kogu kõrghariduse ja teaduse valdkonda juhib faktiliselt Tartu Ülikool. Nad selgitavad oma avalikku kirja haridus- ja teadusminister Mailis Repsile 29. septembri Õpetajate Lehes ning esitavad vastuväiteid Volli Kalmu seisukohtadele 31. oktoobri Eesti Päevalehe artiklis

Maandatud pinged igavas provintsiriigis - Arnold Rüütli viis aastat Kadriorus / Ivar Tallo

Index Scriptorium Estoniae

Tallo, Ivar, 1964-

2006-01-01

Avaliku halduse ekspert analüüsib president Arnold Rüütli tegevust. Võrdlus president Lennart Meriga. Presidendi kantseleist. Vt. samas: Eesti Vabariigi president on meie põhiseaduse järgi Eesti riigipea, kellel on 20 konkreetset ametiülesannet. Lisa: President Rüütli tähtsamad abilised esimesel ametiajal

Värske kohalik kala, iga tarbija unistus / Els Ulman-Kuuskman

Index Scriptorium Estoniae

Ulman-Kuuskman, Els

2016-01-01

Slow Food on mittetulunduslik rahvusvaheline organisatsioon, mis kaitseb ja väärtustab traditsioonilist toidukultuuri. Slow Fish on omakorda üks osa laiemast Slow Food liikumisest ning propageerib, et välismaise kala asemel tarbitaks rohkem meie kohalikke kalu ja lühike tarnekett tagaks kala värskuse ja kvaliteedi

President Ilves : soomepoisid lõid Eesti riigi arusaama liitlassuhete olemusest

Index Scriptorium Estoniae

2007-01-01

President Toomas Hendrik Ilvese kõnest Soome sõdades aastail 1939-1944 osalenud Eesti vabatahtlike auks korraldatud konverentsil 7. detsembril 2007. Ingl. k. lk. 12, pealk.: President Ilves: the Finnish Boys created the Estonian Republic's understanding of allied relations. Ilmunud ka: Meie Kodu 19. dets. 2007, lk. 2 (Allk. Kristel Peterson)

Euroopa Liit üritas hüpata üle oma varju / Andres Herkel

Index Scriptorium Estoniae

Herkel, Andres, 1962-

2008-01-01

Ilmunud ka: Hiiu Leht 27. juuni 2008, lk. 2, Vooremaa 17. juuni 2008, lk. 2, Meie Maa 16. juuni lk. 2. Parlamendiliikme sõnul on EL tulevikku kujundada üritanud lepped liiga mahukad ja abstraktsed selleks, et olla referendumiküsimusena mõistetavad. Artikkel pärineb ajaveebist www.herkel.net

Vana seltsimees, uus Kaukaasia? / Juku-Kalle Raid

Index Scriptorium Estoniae

Raid, Juku-Kalle, 1974-

2008-01-01

Autor leiab, et meie poliitikud ei tunnista Gruusia juhtkonna tõsiseid möödalaskmisi. Kui Gruusia president Mihhail Saakashvili võidaks ka teise valimisvooru, suudaks vähemalt opositsiooniline intelligents võtta teda kogu riigi presidendina. Autor avaldab arvamust Gruusia presidendivalimistel vaatlejana viibinud Riigikogu liikme Evelyn Sepa seisukohtade üle

Rüütli valimist presidendiks peab õigeks kolmveerand rahvast / Rasmus Kagge

Index Scriptorium Estoniae

Kagge, Rasmus

2001-01-01

Uuringufirma Emor küsitlusest selgus, et 74% Eesti elanikest peab Rüütli valimist presidendiks õigeks. Tabel: Rahva toetus ja ootused Rüütlile on kõrged. A. Rüütli tugevad ja nõrgad küljed. Ilmunud ka lüh. Meie Maa (2001/Oct/23) lk. 2

Pikk tee märkamiseni / Katrin Saks

Index Scriptorium Estoniae

Saks, Katrin, 1956-

2008-01-01

Õpilaste koolisuhetest ning koolivägivallast. Ilmunud ka Vooremaa 9. okt. 2008, lk. 2 ; Võrumaa Teataja 11. okt. 2008, lk. 2 ; Koit 11. okt. 2008, lk. 6 ; Meie Maa 13. okt. 2008, lk. 2 ; Pärnu Postimees 10. okt. 2008, lk. 15 ; Virumaa Teataja 15. okt. 2008, lk. 11

Welfare states, the Great Recession and health: Trends in educational inequalities in self-reported health in 26 European countries.

Directory of Open Access Journals (Sweden)

Teresa Leão

Full Text Available Although socioeconomic inequalities in health have long been observed in Europe, few studies have analysed their recent patterning. In this paper, we examined how educational inequalities in self-reported health have evolved in different European countries and welfare state regimes over the last decade, which was troubled by the Great Recession.We used cross-sectional data from the EU-SILC survey for adults from 26 European countries, from 2005 to 2014 (n = 3,030,595. We first calculated education-related absolute (SII and relative (RII inequalities in poor self-reported health by country-year, adjusting for age, sex, and EU-SILC survey weights. We then regressed the year- and country-specific RII and SII on a yearly time trend, globally and by welfare regime, adjusting for country fixed effects. We further adjusted the analysis for the economic cycle using GDP growth, unemployment, and income inequality.Overall, absolute inequalities persisted and relative inequalities slightly widened (betaRII = 0.0313, p<0.05. There were substantial differences by welfare regime: Anglo-Saxon countries experienced the largest increase in absolute inequalities (betaSII = 0.0032, p<0.05, followed by Bismarkian countries (betaSII = 0.0024, p<0.001, while they reduced in Post-Communist countries (betaSII = -0.0022, p<0.001. Post-Communist countries also experienced a widening in relative inequalities (betaRII = 0.1112, p<0.001, which were found to be stable elsewhere. Adjustment for income inequality only explained such trend in Anglo-Saxon countries.Educational inequalities in health have overall persisted across European countries over the last decade. However, there is considerable variation across welfare regimes, possibly related to underpinning social safety nets and to austerity measures implemented during this 10-year period.

Estonia taastusravikeskuse termid : Sääse 7, Pärnu = Baths at SPA Estonia : Sääse 7, Pärnu / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2009-01-01

Estonia taastusravikeskuse basseini- ja vesiravikompleksist, mille arhitektid ning sisearhitektid on Edda Soolep ja Jüri Soolep (Archimedium OÜ). Žürii hinnang kultuurkapitali aastapreemiale esitatud hoonele

Korterelamu : Aleksandri 35, Tartu = Apartment building : Aleksandri 35, Tartu / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2009-01-01

Karlova linnaosas asuva korterelamu arhitektuursest lahendusest, žürii hinnang kultuurkapitali aastapreemiale esitatud elamule. Arhitektid Maarja Kask, Ralf Lõoke, Karli Luik ja Kristiina Arusoo (Salto AB)

SPECIFICUL ACTIVITĂŢII SPECIALE DE INVESTIGAŢIE ŞI ACŢIUNII DE URMĂRIRE PENALĂ ÎNTREPRINSE PENTRU ADMINISTRAREA PROBELOR LA CERCETAREA CRIMELOR CIBERNETICE

OpenAIRE

Svetlana PURICI

2016-01-01

Importanţa investigării „criminalităţii informatice” este dictată nu doar de progresul tehnic, dar în special de prezenta bază normativă în reglementările internaţionale şi în legile naţionale ale Republicii Moldova, precum: Legea cu privire la informatică, Legea privind accesul la informaţie etc., reguli ce trebuie aplicate şi care se vor reflecta în viaţa noastră, în special în procesul de apărare a drepturilor în judecată – moment în care importanţa şi influenţa „investigării crimina­lităţ...

Dicty_cDB: AFH242 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available CA sequence update 2001. 6. 2 Translated Amino Acid sequence claywvyntvysytsl*rii...r*snsynirslnykwss*nwc*sleelktslpisnklqs Frame C: claywvyntvysytsl*riikknkkkek*vmfmill*ldqvfqv*cvvin*krmdikf*

Noore looduskaitsja aunimetus Renno Nellisele / ELF

Index Scriptorium Estoniae

2012-01-01

Eestimaa Looduse Fondi žürii otsustas Noore looduskaitsja auhinna anda Tartu ülikooli ökoloogia ja maateaduste instituudi loomaökoloogia õppetooli looduskaitsebioloogia spetsialistile Renno Nellisele

Noorte teatritrupp pääses festivalile / Kristiina Vaarik

Index Scriptorium Estoniae

Vaarik, Kristiina

2007-01-01

Kooliteatrite festivali žürii valis Viljandis teatritrupi Children of Aunt Rabbit ja Kadri Noormetsa kirjutatud "Antropofoobia" esinema Tartusse teatrifestivalile "Draama", mis toimub 1.-8. septembrini 2007

Reprezentarea cunoaşterii de la schemele de clasificare la Web-ul semantic (I

Directory of Open Access Journals (Sweden)

Silvia-Adriana Tomescu

2014-01-01

Full Text Available În acest eseu ne propunem să investigăm cunoaşterea ca modalitate de reprezentare a lumilor posibile prin scheme de clasificare, taxonomii, ontologii si web semantic. Ne concentrăm investigaţia pe coordonata istorică şi pe metodele şi limbajele de reprezentare. În acest sens, am investigat preocupările de clasificare a cunoştinţelor, de la perioada biblică în care metafora copacului concentra esenţa cunoaşterii, la clasificarea lui Francis Bacon şi mai apoi la Paul Otlet, am analizat limbajele utilizate in cîmpurile ştiinţifice şi ulterior în cel al ştiinţei informării, cu accent pe optimizările aduse de ICT: hypertext si web semantic. Am acordat o atenţie deosebită metodelor de construcţie a cunoaşterii prin limbaj matematic şi standarde de interschimb. Justificarea abordării vine din fundamental filosofic şi logic al reprezentării cunoaşterii care subliniază idea că numai domeniile ştiinţifice bine structurate pot asigura progresul societăţii.

FITOHORMONII – MODULATORI AI ACTIVITĂŢII ENZIMELOR ANTIOXIDANTE LA PLANTE ÎN CONDIŢII DE SECETĂ

Directory of Open Access Journals (Sweden)

Anastasia ŞTEFÎRŢĂ

2016-02-01

Full Text Available În experienţe realizate în diferite condiţii de umiditate s-a demonstrat că deshidratarea plantelor de Ph.vulgaris L., cauzată de secetă, este asociată cu intensificarea formării speciilor reactive de oxigen (SRO şi a destrucţiei oxidative a structurilor celulare. Utilizarea exogenă a fitohormonilor (AIA, CK, GA3 minimizează producerea SRO şi reduce oxi­darea peroxidică a lipidelor din membranele celulare. Optimizarea capacităţii de protecţie de la stresul oxidativ sub in­fluenţa fitohormonilor este o consecinţă a ameliorării statusului apei şi a intensificării activităţii enzimelor antioxidante. THE PHYTOHORMONES – MODULATORS OF PLANTS ANTIOXIDANT ENZYMES ACTIVITY IN DROUGHT CONDITIONSIn experiments conducted under different conditions of moisture has been demonstrated, that dehydration plant Ph. vulgaris L. caused by drought, is associated with intensification of reactive oxygen species formation (ROS and oxidative cell destruction. The use of exogenous phytohormones (IAA, CK, GA3 minimizes the production of ROS and of peroxide oxidation lipids. The optimization of antioxidant protection by the exogenous phytohormones is a consequence of improving the water status and enhancing of the antioxidant enzymes activity. 

Frequency of functional bowel disorders among healthy volunteers in Mexico City.

Science.gov (United States)

Schmulson, Max; Ortíz, Orianna; Santiago-Lomeli, Mariana; Gutiérrez-Reyes, Gabriela; Gutiérrez-Ruiz, María Concepción; Robles-Díaz, Guillermo; Morgan, Douglas

2006-01-01

The frequency of functional bowel disorders (FBD) in Mexico using the Rome II criteria is unknown. The Rome II Modular Questionnaire (RII-MQ) was translated into Spanish in coordination with the Rome Committee and their Latin American program. Volunteers were recruited by advertisement in Mexico City, and administered the RII-MQ. The study population consisted of 324 healthy volunteers, with a mean age of 35.7; 66% were female. The most prevalent disorders were heartburn 35%, irritable bowel syndrome (IBS) 35%, functional bloating 21%, proctalgia fugax 21%, and functional constipation 19%. Based on gender, IBS-C was 4 times more frequent in females than males (19 vs. 4.6%) and functional bloating 3 times more frequent (10 vs. 3.7%). Differences according to occupation included a higher prevalence of ulcer-like dyspepsia (p = 0.04), IBS-C (p = 0.018) and proctalgia fugax (p = 0.034) among students. This is the first study to use RII-MQ to determine the prevalence of FBD in urban Mexico. The prevalence of IBS was significant and is related to a number of factors, including the stress of living in an overpopulated city. Selection bias is likely operative. A community-based study is warranted. Copyright 2006 S. Karger AG, Basel

Gender and regional disparities of tuberculosis in Hunan, China.

Science.gov (United States)

Chen, Mengshi; Kwaku, Abuaku Benjamin; Chen, Youfang; Huang, Xin; Tan, Hongzhuan; Wen, Shi Wu

2014-04-27

Major efforts have been made to improve the health care system in Hunan province, China. The aims of this study were to assess whether and to what extent these efforts have impacted on gender and regional disparities of Tuberculosis (TB) incidence in recent years, especially for less developed areas. We obtained data from the 2005-2009 China Information System for Disease Control and Prevention (CISDCP)to conduct this study in Hunan province. Counties within the province were divided into four regions according to quartiles based on the 2007 per capita GDP. Index of Disparity (ID) and Relative Index of Inequality (RII) were used to measure the disparities of TB incidence in relation to gender and region. Bootstrap technique was used to increase the precision. The average annual incidence of TB was 111.75 per 100,000 in males and 43.44 per 100 000 in females in Hunan. The gender disparity was stable, with ID from 42.34 in 2005 to 43.92 in 2009. For regional disparity, ID, RII (mean) and RII (ratio) decreased significantly from 2005 to 2009 in males (P China, regional disparity in relation to incidence of TB decreased significantly, but the gender disparity remains in the Hunan province.

Tõde selgub võrdluses / Kalev Kotkas

Index Scriptorium Estoniae

Kotkas, Kalev, 1960-

2001-01-01

Vastukaja M. Treiali art. "Sotisaalhoolekande seaduse muudatustest", Vooremaa 11. okt. 2001, lk. 2. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik. Ilmunud ka: Valgamaalane (2001) 27. okt., lk. 2 ; Põhjarannik (2001) 26. okt., lk. 2 ; Hiiu Leht (2001) 19. okt., lk. 2 ; Koit (2001) 20. okt., lk. 6 ; Meie Maa (2001) 23. okt., lk. 2

Teeme eurosuhted selgeks! / Janno Reiljan

Index Scriptorium Estoniae

Reiljan, Janno, 1951-2018

2001-01-01

EL-iga liitumise positiivsed ja negatiivsed küljed. Referendumi korraldamise vajalikkus. Autor: ERL. Parlamendisaadik. Ilmunud ka: Võrumaa Teataja, 12. juuni 2001, lk. 2; Põhjarannik, 14. juuni 2001, lk. 2; Severnoje Poberezhje, 14. juuni 2001, lk. 2; Meie Maa, 22. juuni 2001, lk. 2; Järva Teataja, 26. juuni 2001, lk. 2

V Ameriku bez viz / Jevgenija Garanzha

Index Scriptorium Estoniae

Garanža, Jevgenija, 1979-

2005-01-01

Välisminister Urmas Paeti USA visiidi käigus tuleb jutuks ka võimalik viisavaba USA külastamine ärimeestele ja turistidele, kes ei kavatse riigis üle 90 päeva viibida. Urmas Paet arutab tõenäoliselt ka meie rahukaitseväelaste Iraagis viibimist, suhteid Venemaa ja Ukrainaga

Neoliberalistliku ego õitseng või agoonia? / Mart Ojasalu

Index Scriptorium Estoniae

Ojasalu, Mart

2008-01-01

Järg 27. veebr. lk. 6-7. Autori arvates ei hävita ultraliberalism ainult eetilisi inimsuhteid, vaid mässib eestlased pangalaenude ja liisingutega pangaorjusesse, mille tasateenimisele kulub kogu elu. 21. sajand on loodusvarasid raiskava vabaturumajanduse lõpp, selle vahetab välja ökoloogiline "meie"-tunnetusel põhinev Confuciuse elustiil

Reformierakond soovib Eesti hariduselu kindlatele rööbastele saada / Helmer Jõgi

Index Scriptorium Estoniae

Jõgi, Helmer, 1952-

2006-01-01

Ilmunud ka: Severnoje Poberezhje 5. aug. lk. 2, Valgamaalane, Sakala, Nädaline, Harjumaa, Järva Teataja, Hiiu Leht, Meie Maa, Koit, Vooremaa 8. aug. lk. 2,2,2,2,2,2,2,6,2, Vali Uudised 9. aug. lk. 2, Pärnu Postimees 10. aug. lk. 11. Reformierakonna ettepanekutest hariduselu probleemide lahendamiseks

Head uut eelarveaastat! / Harri Õunapuu

Index Scriptorium Estoniae

Õunapuu, Harri, 1947-

2007-01-01

Ilmunud ka: Vooremaa, 6. jaan. 2007, lk. 2; Meie Maa, 6. jaan. 2007, lk. 2; Valgamaalane, 6. jaan. 2007, lk. 2; Harjumaa, 9. jaan. 2007, lk. 2; Hiiu Leht, 9. jaan. 2007, lk. 2; Põhjarannik, 10. jaan. 2007, lk. 2; Severnoje Poberezhje, 10. jaan. 2007, lk. 2. Parlamendiliige tutvustab 2007. aasta riigieelarvet

Kõik müügiks / Ela Tomson

Index Scriptorium Estoniae

Tomson, Ela, 1945-

2006-01-01

Ilmunud ka: Severnoje Poberezhje, Pärnu Postimees 11. nov. lk. 2, 19, Valgamaalane, Harjumaa, Hiiu Leht, Vooremaa 14. nov. lk. 2, Vali Uudised 15. nov. lk. 2, Sakala 24. nov. lk. 2, Meie Maa 25. nov. lk. 2. Parlamendiliige tunneb muret rahva tervise, liikluskultuuri ning noorte hulgas suureneva alkoholi tarbimise üle

Kuula ka neid

Index Scriptorium Estoniae

2012-01-01

Lühidalt heliplaatidest: Wagner, Strauss, Seeger. Eesti Rahvusmeeskoor, eesti Kaitseväe Orkester; Kalinka. Lembit Tolga; Cesena. Graindelavoix, Björn Schmelzer; Igavene suvi. Allan Vainola & Unenäopüüdjad; Odysseia. European Jazz Motion. Meie aeg on käes. August Hunt; Maksmata võlad. legshaker; Magnificat. Kammerkoor Studio Vocale

Vabariigi president kohtus OECD peasekretäriga

Index Scriptorium Estoniae

2008-01-01

President Toomas Hendrik Ilves kohtus 12. veebruaril 2008 Tallinnas Majandusliku Koostöö ja Arengu Organisatsiooni (OECD) peasekretäri Angel Gurria'ga, tänades teda panuse eest organisatsiooni laienemispoliitika edendamisel. Ilmunud ka: Meie Kodu 20. veebr. 2008, lk. 3, pealk.: President Ilves kohtus OECD peasekretäriga (Allk. Kristel Peterson)

Kuidas edasi, Eesti? / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2002-01-01

President A. Rüütli uusaastapöördumine. Ilmunud ka: Postimees, Molodjozh Estonii, Maaleht, Estonija, Põhjarannik, Severnoje Poberezhje 3. jaan. lk. 3,2,7,3, Meie Maa 3. jaan. lk. 2, Hiiumaa 3. jaan. lk. 2, Virumaa Teataja 3. jaan. lk. 7. (Molodjozh Estonii, Estonija, Maaleht, Põhjarannik, Severnoje Poberezhje täistekst).

Ühe ajastu lõpu algus / Kalev Kask

Index Scriptorium Estoniae

Kask, Kalev

2004-01-01

Ilmunud ka: Meie Maa, 9. nov. 2004, lk. 7. Yasser Arafati tervislik seisund on halvenemas, seni pole ta ametlikult kedagi oma järeltulijaks määranud. Palestiinlased peaksid suutma valida talle kombekohase järglase, vastasel juhul satuvad nad keerulisse võimuvõitlusse, millest saab kasu eelkõige Iisrael, leiab autor

Pension turvaliselt eaka kätte / Maret Maripuu

Index Scriptorium Estoniae

Maripuu, Maret, 1974-

2008-01-01

Muudatustest pensionide ja peretoetuste väljamaksmise korras. Ilmunud ka Harju Ekspress 26. sept. 2008, lk. 6 ; Vooremaa 27. sept. 2008, lk. 2 ; Meie Maa 26. sept. 2008, lk. 2 ; Pärnu Postimees 1. okt. 2008, lk. 11 ; Virumaa Teataja 7. okt. 2008, lk. 15 ; Järva Teataja 21. okt. 2008, lk. 2

Tamkivi : Natura alad on ebaolulised / Ulvar Käärt

Index Scriptorium Estoniae

Käärt, Ulvar, 1982-

2007-01-01

Autori väitel on uus keskkonnaminister Jaanus Tamkivi seadnud kahtluse alla üle-euroopalise tähtsusega Natura 2000 kaitsealade vajalikkuse. Riigikogu liikme Aleksei Lotmani, Eestimaa Looduse Fondi juhatuse liikme Jüri-Ott Salmi hinnanguid. Kommenteerib Hannes Veinla. Vt. ka Aleksei Lotmani ja Marek Strandbergi kommentaare 12. apr. Meie Maa lk. 2

Tallink Silja AB juht Kadri Land : eelistan entusiastlikke eksimusi lõputule ja laisale halale / Kadri Land ; interv. Andres Reimer

Index Scriptorium Estoniae

Land, Kadri

2008-01-01

Tallink Silja AB juht vastab küsimustele, miks Tallink ei huvitu Sillamäe-Kotka või Saaremaa laevaliinist, mille poolest erineb Tallinki juhtimismeetod vana Silja omast, mida on eestlastel rootslastele õpetada, kas meie turismisektor suudab Eestit rootslastele ahvatlevaks muuta, miks Tallink Silja pole veel avanud Stockholm-Peterburi liini. Diagramm: Tallink Grupp

CV : [luuletused] / Mari Vallisoo

Index Scriptorium Estoniae

Vallisoo, Mari, 1950-2013

2007-01-01

Sisu: CV ; Sõnaraamat ; Tegijad ; "Kus leemekulp?..." ; "Veel üks viimnepäev mis asja teha sellega..." ; "Ülemise riiuli ääre pääl...", "Alkeemik Alberti elamus...", "Valge pulber veel enam valgega...", "Meie isa, kes sa...", "Ükskord, kui Maa...", "Kevadvesi ja -pori...", "Mõisnik Meeskurat müüs mu vaarisale..."

Pensionäride hambahüvitis kahekordseks / Tõnis Kõiv

Index Scriptorium Estoniae

Kõiv, Tõnis, 1970-

2006-01-01

Eesti Haigekassa nõukogu otsustas 24. novembril tõsta pensionäridele makstava hambaproteesihüvitise 4000 kroonini. Sama ka Nädaline 2. dets. 2006, lk. 2 ; Meie Maa 5. dets. 2006, lk. 2 ; Vooremaa 5. dets. 2006, lk. 2 ; Valgamaalane 5. dets. 2006, lk. 2 ; Põhjarannik 12. dets. 2006, lk. 2

Pahupidi presidendikampaania / Jaak Allik

Index Scriptorium Estoniae

Allik, Jaak, 1946-

2006-01-01

Autor leiab, et Tarvastu vallavolikogu koalitsiooni otsus presidendivalimistel Arnold Rüütlit mitte toetada on teatud erakondade negatiivne valimiskampaania. Ilmunud ka Põhjarannik, 2006/Apr/20, lk. 2 ; Meie Maa, 2006/Apr/20, lk. 2 ; Vooremaa, 2006/Apr/20, lk. 2 ; Sakala, 2006/Apr/18, lk. 2 ; Severnoje Poberezhje, 2006/Apr/20, lk. 2

Eesti on sündinud emaarmastusest / Lennart Meri

Index Scriptorium Estoniae

Meri, Lennart, 1929-2006

2001-01-01

Lennart Meri emadepäeva kõne, 13. mai 2001. Kodu kujundab lapse tuleviku, järelikult Eesti tuleviku. Kas Eesti suudab kodust ilmajäänud lastele pakkuda uut kodu. Ilmunud ka: Järva Teataja, 15. mai 2001, lk. 2 Meie Kodu (Toronto), 23. mai, lk. 1, pealk.. Emadepäeval

Eesti president Vene välisministri avaldusest / Lennart Meri ; intervjueerinud Peter Marcus

Index Scriptorium Estoniae

Meri, Lennart, 1929-2006

1995-01-01

Lennart Meri hinnang Andrei Kozõrevi avaldusele. Ilmunud ka: Rahva Hääl, 21. apr. 1995, lk. 1, pealkiri: President Meri kurvastab Venemaa välisministri avalduse peale : vene poliitikud pole ajaloost õppust võtnud ; Eesti Päevaleht = Estniska Dagbladet, 27. apr., lk. 2 ; Meie Kodu = Our Home, 10. mai, lk. 1.

Vabadussamba parimad ideed tulid tudengitelt / Garel Püüa

Index Scriptorium Estoniae

Püüa, Garel

2007-01-01

Tallinna Vabadussamba ideekonkursil teise koha saavutanud töö "Meie inimesed" keskendus moodsa linnaruumi loomisele (autorid Marten Kaevats, Mihkel Kaevats, Ülo Kaevats, Peeter Vihma, Merit Kask ja Martin Sookael), kolmanda koha töö "Illusioon" oli abstraktsem (autorid Martin Tago, Tõnis Malkov, Kertu Tuberg ja Laura Kuusk). Kommenteerib Ülar Mark

PREZICEREA PERFORMANŢELOR STUDENŢILOR FOLOSIND ÎNVĂŢAREA AUTOMATĂ (Machine Learning

Directory of Open Access Journals (Sweden)

Maria CRISTEI

2017-08-01

Full Text Available În prezent, învăţarea automată (machine learning ocupă un loc important în inteligenţa artificială, preocupându-se de dezvoltarea algoritmilor ce permit unui sistem informatic să înveţe date, reguli şi algoritmi. Învăţarea automată pre­supune în primul rând identificarea şi implementarea unei modalităţi cât mai eficiente de reprezentare a informaţiilor, în sensul facilitării căutării, reorganizării şi modificării acestora. În acest sens, în prezentul articol se descrie utilitatea şi aplicabilitatea tehnicilor de învăţare automată supervizată la problemele de predicţie şi implementarea acestora în dez­vol­tarea aplicaţiilor informatice. Aplicaţia elaborată este unică prin felul ei de executare a modelului machine learning de predicţie. Metodologia folosită în aplicaţia elaborată este mixtă, cuprinzând tehnologii complexe de ultimă oră: mediul de dezvoltare Jupyter Notebook, limbajul de programare Python împreună cu cele mai populare librării ale acestuia utilizate în machine learning, instrumente de dezvoltare a aplicaţiei web Flask.PREDICTING STUDENT PERFORMANCE USING MACHINE LEARNINGAt present, machine learning occupies an important place in artificial intelligence, and is concerned with the development of algorithms that allow an information system to learn data, rules, and algorithms. Automatic learning involves first and foremost the identification and implementation of a more efficient way of representing information in order to facilitate search, reorganization and change. In this respect, this article describes the utility and applicability of supervised auto­mated learning techniques to prediction problems and their implementation in the development of computer applications. The elaborate application is unique in its way of executing the Machine learning prediction model. The methodology used in the developed application is mixed, including state-of-the-art complex

Rotermanni soolalao juurde rajatakse urbanistlik park / Kertu Kalmus

Index Scriptorium Estoniae

Kalmus, Kertu

2008-01-01

Eesti Arhitektuurimuuseumi korraldatud Rotermanni soolalao esise urbanistliku pargi võistluse võitis Villem Tomiste töö "Piazza". Žürii esimees Eesti Arhitektuurimuuseumi direktor Karin Hallas-Murula

"Berlinale" - žürii eelistas poliitilisi filme

Index Scriptorium Estoniae

2006-01-01

56. Berliini filmifestivali filmide auhindamisest - Kuldkaru saanud Jasmila Zhbavici "Grbavica", režii Hõbekaru saajad britid Michael Winterbottom ja Mat Whitecross filmi eest "Teekond Guatanamosse" ("The Road to Guantanamo"). Lisatud "Berliini 56. filmifestivali põhiauhinnad"

Seymour Benzer and T4 rII

Indian Academy of Sciences (India)

Srimath

and carried out research in the area of microbial ... than a decade. As the story goes, his research output in phage .... type copy of the gene by a cross-over event between the mutations ... measurements in the above experiment; a qualitative screening to ..... determined by the method described above, the next step was to.

Eesti disain on kõva, ent see tuleb moondada ekspordiks / Michael Thomson ; interv. Urmas Oja

Index Scriptorium Estoniae

Thomson, Michael

2008-01-01

Euroopa Disainiassotsiatsioonide Liidu presidendi ja Tallinnas toimunud festivali Disainiöö Eesti disainiauhinna Bruno žürii juhi Michael Thomsoni arvamus eesti disainist ning disainipoliitika vajalikkusest Eestis. Auhinnasaajate nimekiri

USA toetus Eestile

Index Scriptorium Estoniae

2007-01-01

Ameerika Ühendriikide riigisekretär Condoleezza Rice kinnitas 3. mail 2007 telefonikõnes president Toomas Hendrik Ilvesele USA toetust Eestile ning tõsist muret Venemaa käitumise üle oma naaberriigi suhtes. Ilmunud ka: Meie Kodu 9. mai 2007, lk. 2, pealk.: USA riigisekretär Vabariigi Presidendile: Ühendriigid toetavad Eestit

Kas Eesti poliitilisel maastikul on veel harimata põlde? / Toomas Paur

Index Scriptorium Estoniae

Paur, Toomas

2002-01-01

Ilmunud ka: Valgamaalane 4. apr. lk. 2, Vooremaa, Harjumaa, Nädaline 9. apr. lk. 2;2;5, Sakala 10. apr. lk. 2, Meie Maa 13. apr. lk. 2, Järva Teataja 18. apr. lk. 2. Erakonnas olevatel inimestel on ühtne arusaam avalike asjade korraldamisest, neid seob soov luua arengustrateegia riigile ja rahvale. Autor: ERL

Kadriorus pidutsenud noored said trahvi

Index Scriptorium Estoniae

2006-01-01

Noortepeod Kadrioru presidendilossis. Politsei karistas Kadrioru lossis pidutsenud 17 noorukit suitsetamise ja alkoholi tarbimise eest trahviga. Ida politseiosakonna ülemkomissari Margus Kotter'i kommentaar. Ilmunud ka Eesti Päevaleht, 2006/Mar/4, lk. 5 ; Meie Maa, 2006/Mar/4, lk. 1 ; Järva Teataja, 2006/Mar/4, lk. 1 ; Põhjarannik, 2006/Mar/4, lk. 3

President kinnitas riigieelarve

Index Scriptorium Estoniae

2003-01-01

Pealkiri ajalehes Postimees (2003/Dec/30) lk. 3: "President kuulutas välja tuleva aasta riigieelarve". Ilmunud ka Meie Maa (2003/Dec/30) lk. 1 ; SL Õhtuleht (2003/Dec/30) lk. 2 ; Virumaa Teataja (2003/Dec/30) lk. 1. President Arnold Rüütel allkirjastas otsuse, millega kuulutas välja 2004. aasta riigieelarve

Paranoilisi mõtteid / Slavoj Zhizhek ; tõlk. Märt Väljataga

Index Scriptorium Estoniae

Zhizhek, Slavoj

2003-01-01

Autori arvates peaksime olema valvsad, et mitte võidelda vales lahingus: vaidlused selle üle, kui halb on Saddam või kui palju sõda maksma läheb, on valevaidlused. Tähelepanu tuleb pöörata sellele, mis toimub meie ühiskonnas, missugune kultuur on tekkimas Läänes "terrorivastase" sõja tulemusena

Viimsepäeva ootuses tasub panustada inimesele / David Vseviov

Index Scriptorium Estoniae

Vseviov, David, 1949-

2009-01-01

Progress on loonud ühiskonna, mille hävitamine on suhteliselt lihtne. Hävinguks piisab infoühiskonna toimimisaluste kadumisest ja sellele järgnevast peataolekust. Kui terroristid peaksid lõhkama tuumapommi atmosfääris, ei sõltu meie tsivilisatsiooni saatus saavutustest elektroonilise infrastruktuuri täiustamisel, vaid klassikalistest inimväärtustest

Uus etapp Iisraeli võitluses palestiinlastega / Kalev Kask

Index Scriptorium Estoniae

Kask, Kalev

2004-01-01

Ilmunud ka: Meie Maa, 27. apr. 2004, lk. 6. Iisraeli ja Hamasi vahelise võitluse ägenemise käigus tapeti Iisraeli julgeolekujõudude poolt Palestiina äärmusrühmituse Hamas juht Abdel-Aziz al-Rantisi. Lähis-Ida rahuplaani hakkavad Berliinis arutama rahuprotsessi nelja osapoole esindajad - USA, Euroopa Liit, ÜRO ja Venemaa

Jätke maksud võimumängudest puutumata!

Index Scriptorium Estoniae

2005-01-01

Ilmunud ka: Maksumaksja 2005/Mar lk. 6-7, Meie Maa 9. märts lk. 5, Sakala 10. märts lk. 2. Severnoje Poberezhje 8. märts, lk. 2. Eesti Maksumaksjate Liit tuletab meelde, et koalitsioonileppes on ette nähtud, et riigieelarve hoitakse tasakaalus ning otseseid makse alandatakse üksikisiku tulumaksu kaudu

Tallinna lennujaam nimetati Lennart Meri nimeliseks

Index Scriptorium Estoniae

2009-01-01

Tallinna lennujaamale Lennart Meri nime andmise tseremoonial 29. märtsil 2009 esines kõnega ka president Toomas Hendrik Ilves. Ilmunud ka: Vaba Eesti Sõna 2. apr. 2009, lk. 1, pealk.: Tallinna Lennujaam kannab nüüd Lennart Meri nime; Meie Kodu 8. apr. 2009, lk. 1, pealk.: Tallinna Lennujaam sai presidendi nime

SARCINILE ŞI ATRIBUŢIILE PROFESIONISTULUI CONTABILITĂŢII MANAGERIALE ÎN ERA GLOBALIZĂRII ŞI TEHNOLOGIZĂRII

Directory of Open Access Journals (Sweden)

Ştefan Pete

2011-01-01

Full Text Available During the recent years managerial accounting and the managerial accounting profession attracted high level of interest from both researchers and practitioners. Researchers consider that the role of managerial accounting and managerial accountants changed from beingoriented around number crunching and maintaining the overall functioning of the accounting systems to an increasingly business-oriented role (Jarvenpaa, 2007. Because of these changes the purpose of this paper is to present how managerial accounting and the managerial accounting profession changed all over the world and in Romania. After analyzing the existing literature in the field we would like to identify the skills and competences of yesterday’s and today’s accounting professional, worldwide and within Romanian organizations, pointing out that globalization and intensive competition must lead to interdisciplinary and flexible managerial accounting systems and accounting professionals.

Kaubamaja Naistemaailm = Tallinn Kaubamaja Ladies' World / Külli Salum, Riina Harik

Index Scriptorium Estoniae

Salum, Külli, 1971-

2013-01-01

Tallinna Kaubamaja Naistemaailma (Gonsiori 2) sisekujundusest. Autorid: Külli Salum ja Riina Harik (Saha IN). Skulptuurid: Kalle-Priit Pruuden. Sisearhitekti ja ESLi aastapreemiate žürii liikme Tarmo Piirmetsa arvamus

Kesklinna politseihoone = The Central Tallinn Police Department / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Kolde pst. 65 asuva Kesklinna politseihoone arhitektuursest lahendusest. Arhitekt, sisearhitekt Meeli Truu, kaasautor Gersti Siimon (AS Nord Projekt). Žürii liikme Kalle Komissarovi hinnang kultuurkapitali aastapreemiale esitatud hoonele

Viimsi Püha Jaakobi kirik = Jacob's Church in Viimsi / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2009-01-01

Kirikuhoonest (Nurme tee 3, Pringi küla, Viimsi vald), mille arhitekt on Martin Aunin, kaasautor Erkki Ristoja ja konstruktor Kristjan Kaares. Žürii hinnang kultuurkapitali aastapreemiale esitatud hoonele

Tallinna Teletorn = Tallinn's Television Tower / Andrus Kõresaar

Index Scriptorium Estoniae

Kõresaar, Andrus, 1975-

2013-01-01

Renoveeritud Teletornist. Ekspositsiooni autorid: Andrus Kõresaar, Liis Lindvere, Raili Paling, sisearhitektid: Liis Lindvere, Raili Paling, Margit Argus (KOKO Arhitektid). Arhitekti ja ESLi aastapreemiate žürii liikme Raivo Puusepa arvamus

"Live 8" tähti ei auhinnata

Index Scriptorium Estoniae

2006-01-01

Briti muusikapreemia Brit Awards žürii ei võtnud parima kontsertesituse auhinnapretendentide nimekirja ansamblit Pink Floyd ja lauljat Robbie Williamsi, kuna nende 20-minutiline esitus polevat auhinna saamiseks veenev

Ministrite umbusaldamise mõttekusest / Janno Reiljan

Index Scriptorium Estoniae

Reiljan, Janno, 1951-2018

2001-01-01

Poliitika peab muutuma ausamaks, selgemaks ja rahvast teenivaks. Umbusaldusavalduse mõte peitub probleemide avalikustamises ja arutamises kõrgeimal tasemel. Autor: ERL. Palramendisaadik. Ilmunud ka: Koit, 26. apr. 2001, lk. 6; Meie Maa, 26. apr. 2001, lk. 2; Molodjozh Estonii, 27. apr. 2001, lk. 2; Valgamaalane, 3. mai 2001, lk. 2; Nädaline, 10. mai 2001, lk. 4

Majanduse aluseks on tarbimine / Kristo Reinsalu

Index Scriptorium Estoniae

Reinsalu, Kristo

2001-01-01

Ilmunud ka: Meie Maa, 24. okt. 2001, lk. 5; Harjumaa, 26. okt. 2001, lk. 5; Valgamaalane, 30. okt. 2001, lk. 6; Vooremaa, 1. nov. 2001, lk. 3; Hiiu Leht : Käina Kuller, 9. nov. 2001, lk. 3; Järva Teataja, 23. nov. 2001, lk. 2. Sularahanõudluse kasvutempode aeglustamisele aitab kaasa ka eraisikute tarbimiskulutuste katmine. Krediitkaartide populaarsuse kasv

Eesti eest. Oleme õiglased. Oleme tugevad. Oleme profid

Index Scriptorium Estoniae

2004-01-01

Ilmunud ka: Nädaline, 12. juuni 2004, lk. 20; Meie Maa, 12. juuni 2004, lk. 5; Koit, 12. juuni 2004, lk. 8; Valgamaalane, 12. juuni 2004, lk. 5; Lääne Elu, 12. juuni 2004, lk. 16; Sakala, 12. juuni 2004, lk. 16. Valimisreklaam. Isamaaliidu kandidaadid Euroopa Parlamenti vastavad küsimustele Euroopa Liidu ja Isamaaliidu valimisprogrammi kohta

Eesti Kodutöönduse Edendamise Keskselts

Index Scriptorium Estoniae

2003-01-01

Täienduskursused Tallinna Rahvaülikoolis: 17. ja 18. X "Rahvakunsti alused" (E. Kangilaski, M. Kõiva, K. Summatavet, A. Raud), 15. ja 29. X, 12. ja 26. XI, 10. XII "Meie rahvarõivas" (I. Tõnurist, S. Laul, K.-A. Püüman, K. Kirme, T. Vint), 5. ja 6. XII "Tootearendus" (K. Pajupuu, P. Valk, K. Viires, L. Kallam)

Esmatähtis on rahva heaolu / Mai Treial

Index Scriptorium Estoniae

Treial, Mai, 1952-

2003-01-01

Ilmunud ka: Meie Maa 7. jaan. lk. 2, Molodjozh Estonii 4. jaanuar lk. 4, Valgamaalane 9. jaanuar lk. 2 "Inimene väärib paremat", Põhjarannik, Severnoje Poberezhje 10. jaanuar lk. 2 "Riik peab senisest rohkem toetama abivajajaid", Vooremaa 18. jaanuar lk. 5. Sotsiaalabi kaudu peab riik tagama piisavalt vahendeid neile, kes ise hakkama ei saa. Sotsiaalhoolekande seadusest

Walt Disney teeninduse maagia / Häli Siimaste

Index Scriptorium Estoniae

Siimaste, Häli

2007-01-01

Raamatus "Ole meie külaline. Klienditeeninduse täiuslikustamise kunst" on Disney Instituudi kogemuste põhjal näidatud, kuidas juhtida protsesse nii, et tulemuseks oleks igapäevane maagiliselt mõjuv teenindus, instituudi tegutsemise põhimõtted. Kvaliteetse teeninduse tsükkel - kogu ettevõtet haarav pidev ringprotsess, mille tulemuseks on viimseni lihvitud teenindus - praktiline maagia

Kui igapäevast elu häirivad kõrvetised... / Selma Teesalu

Index Scriptorium Estoniae

Teesalu, Selma, 1930-

2003-01-01

Vt. ka Hiiumaa 1. märts, lk. 8, Meie Maa 8. märts, lk. 5, Lääne-Harju Ekspress 15. märts, lk. 6, Hiiu Leht 25. märts lk. 4. Kõrvetava tunde taga võib peituda haigus. Arsti poole pöördumise vajalikkuse üle otsustamiseks on lisaks küsimustik

Riigilt saab toetust senisest rohkem inimesi / Heljo Pikhof

Index Scriptorium Estoniae

Pikhof, Heljo, 1958-

2001-01-01

Ilmunud ka: Meie Maa, 30. okt. 2001, lk. 2; Vooremaa, 30. okt. 2001, lk. 2; Koit, 30. okt. 2001, lk. 6; Lääne Elu, 30. okt. 2001, lk. 4. Vastuseks M. Treiali art.-le üle 80-aastastele pensionilisa maksmise kohta. Vanus ei ole objektiivne alus, et lisaraha maksta. Uuest toetuste süsteemist. Autor: Rahvaerakond Mõõdukad

Ajalugu liigub spiraalina ehk uutest ja vanadest riigijuhtidest / Toomas Alatalu

Index Scriptorium Estoniae

Alatalu, Toomas, 1942-

2006-01-01

Ilmunud ka: Hiiu Leht 14. märts lk. 2, Meie Maa 15. märts lk. 2, Za Narod nr. 4 lk. 1, Teataja : Eestimaa Rahvaliidu ajaleht nr. 4 apr. lk. 1. Autori hinnangul minnakse uuele ühiskondlikule korrale üldjuhul üle mõne eelmise korra tähtsa tegelase juhtimisel, näiteid ajaloost

Elu maal / Igor Gräzin

Index Scriptorium Estoniae

Gräzin, Igor, 1952-

2006-01-01

Ilmunud ka: Severnoje Poberezhje 6. dets. lk. 2, Võrumaa Teataja, Vooremaa 7. dets. lk. 2, Hiiu Leht 8. dets. lk. 2, Lääne Elu, Koit, Elva Postipoiss 9. dets. lk. 2,6,4, Meie Maa 13. dets. lk. 2, Sakala 22. dets. lk. 2. Autori sõnul jätkab Euroopa Liidu maaelupoliitika rahvusvastaseid traditsioone

President Ilves New Yorgi eestlaskonnale : vaadake "Talendid koju" programmi kui võimalust

Index Scriptorium Estoniae

2010-01-01

President Toomas Hendrik Ilves ja proua Evelin Ilves külastasid 25. septembril 2010 New Yorgi Eesti Majas tegutsevat Eesti kooli ja osalesid New Yorgi eestlaskonnale korraldatud vastuvõtul. Ilmunud ka: Meie Kodu 6. okt. 2010, lk. 2, pealk.: President Ilves kutsus New Yorgi eestlasi kodumaale tagasi. Töövisiit Ameerika Ühendriikidesse 20.-27.09.2010

Matemaatiline juhtimine / Stephen Baker

Index Scriptorium Estoniae

Baker, Stephen

2008-01-01

Autori raamat "Numeraadid" tutvustab matemaatikavõlureid, kes tuhnivad meie andmetes. Numeraatide üks paljutõotavamaid laboreid on töökohad, kus saab uurida iga klahvivajutust, hiireklõpsu ja meilisõnumit. Peatükis "Töötajad" vaatleb autor IBMi, kus matemaatikud loovad omaenda kolleegide käitumist prognoosivaid mudeleid. Lisa: Juhtimise teadus. Stopperist matemaatiliste mudeliteni; Viited

Hoolekandeasutustele ei sobi reorganiseerimiskava / Piret Hartman

Index Scriptorium Estoniae

Hartman, Piret

2005-01-01

Ilmunud ka Põhjarannik 23. märts lk. 2, Severnoje Poberezhje 23. märts lk. 2, Meie Maa 7. apr, lk. 2, Nädaline 7. apr. lk. 5, Teataja : Eestimaa Rahvaliidu Ajaleht Apr nr. 4 lk. 3. Riigikogu Rahvaliidu fraktsiooni nõunik sotsiaalfoorumist, kus osalesid hoolekandeasutuste ja kohalike omavalitsuste esindajad, Eesti Maaomavalitsuste Liidu juhatuse liikmed ning Riigikogu liikmed

Rein Lang : liitriiki ei tule / Rein Lang ; interv. Sten Hansson

Index Scriptorium Estoniae

Lang, Rein, 1957-

2003-01-01

Ilmunud ka: Severnoje Poberezhje 16. juuli lk. 2, Lääne Elu 17. juuli lk. 4, Meie Maa 17. juuli lk. 2, Koit 17. juuli lk. 6, Vooremaa 17. juuli lk. 2, Hiiu Leht 22. juuli lk. 2, Nädaline 2. august lk. 4. Intervjuu Euroopa Liidu tulevikukonvendis osalenud Rein Lang'iga EL-i põhiseaduse projektist

Mõõdukad opositsioonis oma seadustega / Mai Treial

Index Scriptorium Estoniae

Treial, Mai, 1952-

2002-01-01

Ilmunud ka: Tartu : Postimees 1. apr. lk. 2, Meie Maa 27. märts lk. 2, Hiiumaa, Vooremaa, Koit 2. apr. lk. 2;2;6, Sakala 4. apr. lk. 2,Virumaa Nädalaleht nr. 6 lk. 5, Pärnu Postimees 12. apr. lk. 2. Kriitika Mõõdukate ja Eiki Nestori aadressil riikliku pensionikindlustuse seaduse arutelul Riigikogus. Autor: ERL. Parlamendisaadik

Kodus Venus, võõrsil Mars / Priit Simson

Index Scriptorium Estoniae

Simson Priit, 1977-

2007-01-01

Autor leiab, et Eestil ei pole enam vabandusi, miks ta ei peaks hankima rasket sõjatehnikat ja miks peaks keegi teine meie õhuruumi valvama. Autor vaatleb, milline relvastus on mõnedel väikeriikidel, kelle elanike arv ei ületa 6 mln. piiri, ning järeldab, et soovides olla maailma keskmisel tasemel, võiks Eesti muretseda 65 tanki

Me saame USA lubadustesse uskuda: Lennart Meri kõne [Ameerika Ühendriikide asepresidendi Albert Gore'i visiidi ajal] Raekoja platsil 13. märtsil 1995 / Lennart Meri

Index Scriptorium Estoniae

Meri, Lennart, 1929-2006

1995-01-01

Kõne Raekoja platsil. Ilmunud ka: Päevaleht, 14. märts 1995, lk. 1, pealkiri: Lennart Meri kõne Raekoja platsil 13. märtsil 1995 ; Vaba Eestlane, 16. märts, lk. 3, 5, pealkiri: Vabariigi Presidendi Lennart Meri kõne Raekoja platsil 13. märtsil 1995. a. ; Meie Kodu, 29. märts, lk. 1

Perefirma lööb läbi ühise tahtega / Ave Paavo

Index Scriptorium Estoniae

Paavo, Ave

2005-01-01

Perefirma lööb läbi, kui on ühine tahe ja suhted korras. Vt. samas: Töö eesmärk on leivateenimine. OÜ Arenet Servis näitel; Toivo Kens. Investeerime tulevastesse põlvkondadesse. OÜ Viraito näitrel; Kalle Elster. Meie eelis on üksteise kiire mõistmine. AS-i Elstera näitel

Pakendite tagastamine paremini paika! / Marko Pomerants

Index Scriptorium Estoniae

Pomerants, Marko, 1964-

2008-01-01

Pakendiseaduse eelnõust. Ilmunud ka Meie Maa 28. aprill 2008, lk. 2 ; Oma Saar 30. aprill 2008, lk. 5 ; Vali Uudised 30. aprill 2008, lk. 5 ; Koit 3. mai 2008, lk. 3 ; Vooremaa 3. mai 2008, lk. 2 ; Järva Teataja 6. mai 2008, lk. 2, pealkiri kujul: pakendite tagastamist saab parandada ; Virumaa Teataja 29. mai 2008, lk. 11

"Lotte" võitis Venemaal eriauhinna

Index Scriptorium Estoniae

2002-01-01

Südamliku huumoriga joonisfilm "Lotte" (loojad Heiki Ernits, Janno Põldma, Andrus Kivirähk jt.) võitis Moskvas rahvusvahelisel lastefilmide festivalil "Kuldkalake" ("Zolotaja Rõbka") esimese eriauhinna ja žürii diplomi

Ainult kaks küsimust / Kaarel Väli

Index Scriptorium Estoniae

Väli, Kaarel

2011-01-01

Tallinnas toimunud 5. rahvusvahelise laste ja noorte moeteatrite festivali „Max Moda 2011" žürii liige Kaarel Väli põhjustest, miks osutus parimaks Moskva moeteater, Eesti võistlejate esinemisest

Kazhdõi mog bõ vozglavit Dom... / Fabrizio Talia ; interv. Alina Lind

Index Scriptorium Estoniae

Talia, Fabrizio

2006-01-01

Moemaja Moschino peadisaineri, SuperNoova žürii liikme Fabrizio Taliaga konkursist SuperNoova, tööst Moschino jaoks. Konkursil osalenutest meeldisid Aldo Järvsoo, Riina Põldroos ja Xenia Jedomskihh

Pärnu Keskraamatukogu = Pärnu Central Library / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2009-01-01

Raamatukoguhoone arhitektid Andres Ojari, Ilmar Valdur, Markus Kaasik, Kalle Komissarov ja Mihkel Tüür pälvisid Eesti Kultuurkapitali 2008. aasta peapreemia. Hoone arhitektuursest lahendusest, žürii hinnang hoonele

Animaneste PÖFFi filmikärje kannudes / Tarmo Teder

Index Scriptorium Estoniae

Teder, Tarmo, 1958-

2003-01-01

Pimedate Ööde Filmifestivali raames toimuv animafilmide festival Animated Dreams. Lähemalt saksa ja eesti animaatorite sidemetest. Žürii koosseis : Adam Benjamin Elliot (Austraalia), Kristen Winter (Saksamaa) ja Priit Tender

Forma odezhdõ - v tsvetotshek / Ksenia Repson

Index Scriptorium Estoniae

Repson, Ksenia

2003-01-01

Tatjana Tridvornova organiseeritud lilleballist Tallinnas. Algas lillekleitide defileega Saku Suurhallis ja jätkus lillekleitide konkursiga klubis Opium. Žürii koosseis. Võitja on läti florist Druvis Ciritis lillekleidiga "Puudutus"

Vene Kultuurikeskus = The Russian Culture Centre / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Mere puiestee 5 asuva hoone (arhitekt A. Kuznetsov, 1954) restaureerimisest. Arhitekt Niina Mäger, sisearhitekt Anne Tamverk. Ajaloolane Aleksandr Pantelejev. Žürii liikme Mait Summataveti hinnang kultuurkapitali aastapreemiale esitatud hoonele

Eesti kineastide dessant Berliini / J. R.

Index Scriptorium Estoniae

J. R.

2007-01-01

57. Berlinale lastefilmide võistlusprogrammis on ka "Leiutajateküla Lotte". Rain Tolk esindab Eestit Euroopa noorte näitlejate tutvustuspromotsioonis Shooting Star. Riina Sildos on lühifilmide žüriis

Köied ja sõlmed tõid Katrina Kaubile võidu / Monika Puutsa

Index Scriptorium Estoniae

Puutsa, Monika

2007-01-01

Supernoova moevõistluse tulemustest. Noorte disainerite auhind Katrina Kaubile oli 20 000 krooni ja Supernoova hõbedane pross, vanemas kategoorias Liisi Eesmaale 50 000 krooni. Žürii koosseis. Katrina Kaubi kommentaarid

Welfare states, the Great Recession and health: Trends in educational inequalities in self-reported health in 26 European countries.

Science.gov (United States)

Leão, Teresa; Campos-Matos, Inês; Bambra, Clare; Russo, Giuliano; Perelman, Julian

2018-01-01

Although socioeconomic inequalities in health have long been observed in Europe, few studies have analysed their recent patterning. In this paper, we examined how educational inequalities in self-reported health have evolved in different European countries and welfare state regimes over the last decade, which was troubled by the Great Recession. We used cross-sectional data from the EU-SILC survey for adults from 26 European countries, from 2005 to 2014 (n = 3,030,595). We first calculated education-related absolute (SII) and relative (RII) inequalities in poor self-reported health by country-year, adjusting for age, sex, and EU-SILC survey weights. We then regressed the year- and country-specific RII and SII on a yearly time trend, globally and by welfare regime, adjusting for country fixed effects. We further adjusted the analysis for the economic cycle using GDP growth, unemployment, and income inequality. Overall, absolute inequalities persisted and relative inequalities slightly widened (betaRII = 0.0313, pAnglo-Saxon countries experienced the largest increase in absolute inequalities (betaSII = 0.0032, pAnglo-Saxon countries. Educational inequalities in health have overall persisted across European countries over the last decade. However, there is considerable variation across welfare regimes, possibly related to underpinning social safety nets and to austerity measures implemented during this 10-year period.

METODE ALTERNATIVE DE FINANȚARE A STUDIILOR ÎN ÎNVĂȚĂMÂNTUL SUPERIOR

Directory of Open Access Journals (Sweden)

Olga CONENCOV

2018-03-01

Full Text Available La etapa actuală, finanțarea publică a studiilor în învățământul superior nu este suficientă pentru asigurarea unei pregătiri calitative și competitive, iar resursele financiare personale ale populației sunt prea modeste pentru a achita taxele de studii în corespundere cu costurile financiare reale suportate de instituția educațională. În acest context, re­ieșind din tendințele profilate pe plan internațional, apare necesitatea căutării unor metode alternative de finanțare a studiilor, în vederea dezvoltării capitalului uman educațional autohton și în contextul ameliorării calității vieții.ALTERNATIVE METHODS OF FINANCING STUDIES IN HIGHER EDUCATIONAt present, public funding for higher education studies is not sufficient to ensure qualitative and competitive training, and the personal financial resources of the population are too modest to pay for the study fees in line with the real financial costs incurred by the educational institution. In this context, based on the internationally developed trends, there is a need to seek alternative methods of financing studies, in order to develop the local educational human capital and to improve the quality of life.

CONSIDERAȚII TEORETICO-METODOLOGICE PRIVIND DESFĂȘURAREA AUTOEDUCAȚIEI ȘCOLARULUI MIC

Directory of Open Access Journals (Sweden)

Natalia POPA

2017-07-01

Full Text Available Analiza literaturii de specialitate, observațiile noastre, rezultatele chestionării și ale conversației cu cadrele didactice demonstrează posibilitățile realizării unei auto/educații de calitate și necesitatea depunerii unui efort intelectual și moral-volitiv atât din partea elevilor, cât și a părinților și pedagogilor în direcția autoinstruirii, autoeducației și învățării pe parcursul vieții. În acest sens a fost elaborată matricea achizițiilor principale ale școlarului mic, care orientează adulții în direcția strategiilor ce pot fi aplicate în stimularea autoeducației școlarului mic.THEORETICAL AND METHODOLOGICAL CONSIDERATIONS ON UNFOLDING PRIMARY SCHOOL CHILDREN SELF-EDUCATIONThe literature analysis, our observations, results of questioning and conversation with teachers demonstrate the possibilities of achieving quality self/education and the need to make an intellectual and moral-volitional effort, both from students, parents and teachers towards self-training, self-education and lifelong learning. In this respect, the matrix of main achievements of small pupil, guiding adults towards strategies that can be applied to stimulate self-education primary school children has been developed.

Personal Verification/Identification via Analysis of the Peripheral ECG Leads: Influence of the Personal Health Status on the Accuracy

Directory of Open Access Journals (Sweden)

Irena Jekova

2015-01-01

Full Text Available Traditional means for identity validation (PIN codes, passwords, and physiological and behavioral biometric characteristics (fingerprint, iris, and speech are susceptible to hacker attacks and/or falsification. This paper presents a method for person verification/identification based on correlation of present-to-previous limb ECG leads: I (rI, II (rII, calculated from them first principal ECG component (rPCA, linear and nonlinear combinations between rI, rII, and rPCA. For the verification task, the one-to-one scenario is applied and threshold values for rI, rII, and rPCA and their combinations are derived. The identification task supposes one-to-many scenario and the tested subject is identified according to the maximal correlation with a previously recorded ECG in a database. The population based ECG-ILSA database of 540 patients (147 healthy subjects, 175 patients with cardiac diseases, and 218 with hypertension has been considered. In addition a common reference PTB dataset (14 healthy individuals with short time interval between the two acquisitions has been taken into account. The results on ECG-ILSA database were satisfactory with healthy people, and there was not a significant decrease in nonhealthy patients, demonstrating the robustness of the proposed method. With PTB database, the method provides an identification accuracy of 92.9% and a verification sensitivity and specificity of 100% and 89.9%.

Involvement of both protein kinase C and G proteins in superoxide production after IgE triggering in guinea pig eosinophils

Directory of Open Access Journals (Sweden)

Toshiya Aizawa

1997-01-01

Full Text Available To study the function and mechanism of eosinophils via the low affinity IgE receptor (FceRII, we examined the production of 02 metabolites by measuring the luminol-dependent chemiluminescence (LDCL response and the generation of cysteinyl leukotrienes. Eosinophils obtained from guinea pig peritoneal fluid sensitized with horse serum were purified. Luminol-dependent chemiluminescence was induced by stimulation with monoclonal anti-CD23 antibody, but not by mouse serum (controls. The mean (±SEM value of LDCL was 20.6±1.3X103 c.p.m. This reaction consisted of an initial rapid phase and a propagation phase and ended within lOmin. Guinea pig eosinophils were histochemically stained with monoclonal anti-CD23 antibody. The major product generated in the LDCL response was superoxide, as determined by the measurement of superoxide by cytochrome c reduction and the complete inhibitory effect of superoxide dismutase on the LDCL response. Pretreatment with either pertussis toxin or cholera toxin inhibited the LDCL reaction. Depletion of bivalent ions by EDTA inhibited this response and the protein kinase C inhibitor D-sphingosin inhibited both 1-oleoyl-2-acetyl-glycerol-induced and FcϵRII-mediated LDCL. These findings suggest that the NADPH-protein kinase C pathway may be involved in the FceRII-mediated LDCL response in guinea pig eosinophils.

EFICIENTIZAREA OBŢINERII SEDIMENTELOR FURAJERE B12 -VITAMINIZATE DIN APE REZIDUALE AGROINDUSTRIALE: 2. MODIFICĂRI ALE UTILAJULUI

Directory of Open Access Journals (Sweden)

Victor COVALIOV

2017-03-01

Full Text Available Prin modificări constructive ale dispozitivelor bioreactorului şi soluţii noi: separarea zonelor acetogenă şi meta­no­genă în interiorul bioreactorului, recircularea CO2 şi suplimentarea acestuia cu H2 exogen, adsorbţia vitaminei B12 din lichidul postfermentare cu diatomită s-a obţinut ridicarea conţinutului de vitamina B12 în sedimentele epurării fermentativ–metanogene (anaerobe a borhotului postalcoolic până la calitatea de con­centrat furajer B12-vitaminizat, concomitent cu intensificarea producerii biometanului, ca elemente ale ridicării eficienţei ecologo-economice a epurării anaerobe a borhotului.MORE EFFICIENT PRODUCITON OF VITAMINIZED FORAGE SLUDGE CONTAINING B12 FROM AGRO-INDUSTRIAL WASTES: 2. EQUIPMENT MODIFICAITON The increase in vitamin B12 contents in the sludge was obtained resulted from the methanogenic (anaerobic digestion of post-distillery vinasse, through the design modifications of bioreactor interiour, CO2 re-circulation and its interaction with additionally dosed exogenic hydrogen. Vitamin B12 was further adsorbed on diatomite surface from the post-digestion liquid, which made it possible to produce the cattle forage concentrate enriched with vitamin B12. At the same time, biomethane production was intensified, being the element of ecologically-economic efficiency of anaerobic treatment of vinasse (agro-industrial waste.

Politicile patrimoniului cultural în contextul reformei administraţiei publice

Directory of Open Access Journals (Sweden)

Vasile COMENDANT

2018-03-01

Full Text Available Lucrarea reprezintă o analiză complexă a politicilor publice în domeniul patrimoniului cul¬tural național realizate în cadrul reformelor administraţiei publice din Republica Moldova. Sunt examinate programele de reformă a administraţiei publice în domeniul protejării patrimoniului cultural. În procesul cercetării sunt indicate autorităţile administraţiei publice centrale responsabile de realizarea reformelor de salvgardare a patrimoniului cultural în baza politicilor culturale. Investigația ne-a permis să constatăm că, actualmente, o cerinţă de cea mai mare actualitate pentru Republica Moldova este de a determina în cadrul reformei administraţiei publice moda¬lităţile de îmbunătăţire a formelor de protejare a patrimoniului cultural naţional, precum și de implementare a politicilor publice în acest domeniu. Concomitent, a fost elucidată necesitatea dezvoltării de către autorităţile publice a unui dialog intercultural permanent privind politica cul¬turală cu ţările Uniunii Europene și cooperarea în cadrul forurilor internaționale pentru a dezvolta diversitatea culturală și pentru a conserva și a valorifica patrimoniul național cultural și istoric.

Loomaaed tähistab homset 65. sünnipäeva vaoshoitult / Piret Peensoo

Index Scriptorium Estoniae

Peensoo, Piret

2004-01-01

Loomaaia sünnipäeval lõpetatakse IV Läänemeremaade animalistliku skulptuuri festival ja selgitatakse võitjad. Osavõtjate loetelu. Žürii koosseis. Eestist osalevad Aleksander Litvinov ja Rafael Danieljants

Viljandi mõisa aida kohandamine Eesti Pärimusmuusika Keskuseks = Renovation of the Viljandi manor's storehouse into the Estonian Traditional Music Centre / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2009-01-01

Hoone arhitektuuriajaloolised eritingimused koostas Anne Lass, arhitekt on Raivo Mämdmaa, sisearhitekt Kersti Leinbock, konstruktor Hans Priks, sepiste autor Heigo Jelle. Hoonel on klaasist juurdeehitis. Žürii hinnang kultuurkapitali aastapreemiale esitatud sisekujundusele

"Berlinale" võistluslainelt / Endel Link

Index Scriptorium Estoniae

Link, Endel

2007-01-01

Lühidalt 57. Berliini filmifestivalil linastuvatest filmidest. Avafilm on Olivier Dahani "La Mome" Edith Piafist. Lastefilmide võistlusprogrammis on ka "Leiutajateküla Lotte". Riina Sildos on lühifilmide žüriis

Eripreemia Priit Tenderile

Index Scriptorium Estoniae

2000-01-01

Eesti Joonisfilmi film "Viola" võitis VIII Hiroshima rahvusvahelisel animafilmide festivalil žürii eripreemia. Peapreemia sai Kanada "When the Day Breaks" : režissöörid Wendy Tilby ja Amanda Forbis

Niagaara meis ja meie Niagaara kohal / Tõnis Tõnisson

Index Scriptorium Estoniae

Tõnisson, Tõnis, 1945-

2006-01-01

Alonso Alegria näidend "Niagaara" Juuru lähistel Atla mõisas, lavastaja Jaan Urvet. Lisatud Jean Francois Gravelet' ja Alonso Alegria lühitutvustus, allikas "kavaleht". Ajalehe rubriik Eesti teatri aasta 2006 : Teatriküljed, 9

Mis on see meie oma meediaruum? / Katrin Kivimaa

Index Scriptorium Estoniae

Kivimaa, Katrin, 1969-

1999-01-01

Meediakunsti festivali 'Interstanding 3' raames toimunud konverents 'Ülalpool piire'. Kuraator Eric Kluitenbergi, peaesineja sotsioloogiaprofessor Saskia Sasseni, bulgaaria kunstniku Luchezar Boyadjievi esinemisest. Eesti ja internet

BusinessWeek : meie valikuks on Google / Tarvo Vaarmets

Index Scriptorium Estoniae

Vaarmets, Tarvo

2007-01-01

Ajakiri BusinessWeek järjestas viimase kolme aasta tulemuste põhjal Standard & Poor's 500 indeksi koosseisu kuuluvad parimad ettevõtted. Tabel: Ettevõtete edetabel. Vt. samas: Google kroonib edetabelit; Sunoco; Colgate-Palmolive; Avon Products

Meie mees Reykjavikis - see, kes julges / Rein Veidemann

Index Scriptorium Estoniae

Veidemann, Rein, 1946-

2015-01-01

Dokumentaalfilmist "Need, kes julgevad", režissöör Ólafur Rögnvaldsson (Island-Eesti-Läti-Leedu 2015) ETV-s. Film Baltimaade iseseisvumisest ja Islandi tolleaegsest välisministrist Jón Baldvin Hannibalssonist selles protsessis

Manufaktuurideaegne olustik meie ettevõtetes / Silva Männik

Index Scriptorium Estoniae

Männik, Silva, 1974-

2004-01-01

Ilmunud ka: Delovõje Vedomosti 12. mai lk. 5. Eestis leidub palju selliseid ettevõtteid, kus puuduvad normaalsed töötingimused. Vaata samas: Dold Puidutööstuses erakordselt palju tööõnnetusi; Sokitööstus õigustab end veel suurema viletsusega välismaal; Kiosköörid töötavad kuni 24tunniste vahetustega

Meie aja tähtsaim eestlane / Carl Bildt

Index Scriptorium Estoniae

Bildt, Carl, 1949-

2006-01-01

Ilmunud ka: Eesti Päevaleht, SL Õhtuleht 27. märts lk. 3,5. Endise Rootsi Kuningriigi peaministri Carl Bildti mälestuskõne president Lennart Meri riiklikul hüvastijätutseremoonial 26. märtsil 2006 Kadriorus

Meie kõigi televisioon ja raadio / Ela Tomson

Index Scriptorium Estoniae

Tomson, Ela, 1945-

2006-01-01

Eesti Raadio ja Eesti Televisiooni ühinemist hakkaks juhtima uue rahvusringhäälingu juhatus, kelle määrab ametisse poliitikutest koosnev nõukogu. Kultuuriministeeriumi poolt esitatud uue ringhäälinguseaduse eelnõu teemal

Meie kõigi televisioon ja raadio / Ela Tomson

Index Scriptorium Estoniae

Tomson, Ela, 1945-

2006-01-01

Rahvusringhäälingu sõltumatusest ning seaduseelnõust, mis näeb ette ringhäälingunõukogu moodustamist tervikuna poliitikutest proportsionaalsel põhimõttel ehk enamus koalitsioonist ja vähemus opositsioonist

Meie kõigi televisioon ja raadio / Ela Tomson

Index Scriptorium Estoniae

Tomson, Ela, 1945-

2006-01-01

Eesti Raadio ja Eesti Televisiooni ühinemist hakkab juhtima uue rahvusringhäälingu juhatus, kelle määrab ametisse poliitikutest koosnev nõukogu. Kultuuriministeeriumi poolt esitatud uue ringhäälinguseaduse eelnõu teemal

Meie eksport on Soome kapitali käes

Index Scriptorium Estoniae

1995-01-01

Tabelid: Eesti import Soomest 1992-1994.a. Eesti import Soomest ja eksport Venemaale; Eesti import päritolu- ja lähteriigi järgi (1993.a., osakaal %); Soome ja Eesti kogutoodangu struktuur (1992-1994)

Teine nahk ehk Ornament ja meie / Hanno Soans

Index Scriptorium Estoniae

Soans, Hanno, 1974-

2003-01-01

Arhitekt Adolf Loosi suhtumine ornamenti ja nahakaunistustesse, tattoo tagasitulek käibesse läänes XX sajandi II poolel. EKA nahakunsti eriala diplomandi Kerstin Raidma lõputööst, mis sisaldas seeria levinumaid tätoveeringupiirkondi katvaid nahast ehteid, lühidalt sama eriala lõpetaja Agnetha Kurusoni lõputööst "Kest" ja lõputööde hinnetest

Saatchi "Newspeak" - metropol defineerib meie keele? / Jaan Elken

Index Scriptorium Estoniae

Elken, Jaan, 1954-

2010-01-01

Näitusest "Newspeak: British Art Now Part 1" ("Uus kõnepruuk: Briti kunst nüüd. I") Saatchi galeriis Londonis, avatud 17. oktoobrini 2010. Näituse teine osa avatakse 27. oktoobril. Saatchi galeriist

Euroopa Liit - meie uus ühiskodu / Tõnu Prei

Index Scriptorium Estoniae

Prei, Tõnu, 1950-

2006-01-01

Järg 21. märts, 4.,11.,25. apr. lk. 6,6,4. Euroopa Liidu tekkelugu. EL-i institutsioonid. Lisad: Liikmesriigid; Brüssel; Strasbourg; Luxembourg; Ühinenud Euroopa kolm tuhandeaastast pealinna. Vt. samas: Euroopa Ülemnõukogu; Euroopa Liidu Nõukogu; Euroopa Komisjon; Euroopa Parlament; Eesti rahva esindajad Euroopa Parlamendis; Euroopa Kohus; Euroopa Kontrollikoda; Euroopa ombudsman; Euroopa anmekaitseinspektor; Euroopa Keskpank; Euroopa Investeerimispank; Euroopa Investeerimisfond

Huvi või sundus - meie valik / Rein Rebane

Index Scriptorium Estoniae

Rebane, Rein

2011-01-01

Eesti õpilaste tulemused rahvusvaheliste PISA ja TIMSS-i testide põhjal on olnud head. Samadest uuringutest on aga selgunud, et nii Eesti õpilaste kui ka õpetajate rahulolu kooliga on üks madalamaid maailmas

Max Jakobsoni saatuseaastad, soomlased ja meie / Imbi Paju

Index Scriptorium Estoniae

Paju, Imbi, 1959-

2008-01-01

Soome politoloogist ja diplomaadist Max Jakobsonist ja tema uuest raamatust "Saatuseaastad. Soome tõusis, andis Venemaale järele ja pääses". Artiklis on juttu ka Max Jakobsoni suhetest Eesti presidentide Lennart Meri ja Toomas Hendrik Ilvesega

"Meie käisime maailmameistrivõistlustel!" / Tiina Madisson

Index Scriptorium Estoniae

Madisson, Tiina

2012-01-01

Šveitsis 27.-30. oktoobril toimunud 20. ISPU IPO MMist, kus Eestit esindanud suuršnautser Maximus koos perenaise Tiina Madissoniga saavutasid rahvusvahelise teenistuskoerte eksami (IPO) teises raskusastmes kolmanda koha

Moore'i seadus ja meie tulevik / Leo Võhandu

Index Scriptorium Estoniae

Võhandu, Leo, 1929-

2006-01-01

Kiibifirma Intel üks asutajaid Gordon Moore väitis 1965. aastal, et transistorite arv kiibil topeldub iga kahe aastaga ehk loomulik areng ei ole lineaarne, vaid eksponentsiaalne (astmeline). TTÜ emeriitprofessor Moore'i seaduse mõjust ühiskonna arengule. Vt. samas: Leo Võhandu

Kas meie joogivesi on radioaktiivselt ohtlik? / Gunnar Press

Index Scriptorium Estoniae

Press, Gunnar, 1957-

2008-01-01

Sotsiaalministeeriumi tellimusel valminud uuringu kohaselt tarbib umbes 14 protsenti eestlastest maapõuest pumbatud vett, mille radioaktiivsus ületab kehtestatud norme. Vestlusest AS Viimsi Vesi juhataja Toivo Eensaluga

"Gypsy" ehk killuke Ameerikat meie jaoks / Martin Gorris

Index Scriptorium Estoniae

Gorris, Martin

2001-01-01

2. dets. esietendus Vanemuises Ameerika vodevillistaari ja striptiisikuninganna Rose Louise Hovicki memuaaridel põhinev Jule Styne'i muusikal "Gypsy", lavastaja Mare Tommingas, osades Silvi Vrait ja Helena Merzin

Meie näitekirjandus aastal 1931 / Ants Oras

Index Scriptorium Estoniae

Oras, Ants, 1900-1982

2009-01-01

Ülevaade 1931. aasta eesti näitekirjandusest. Pikemalt käsitletakse: Mait Metsanurk "Mässuvaim, ehk, Agulirahvas läheb ajalukku", Hugo Raudsepp "Põrunud aru õnnistus", Agnes Taar "Emake maamuld", Aleksander Antson "Töölise tütar", Artur Adson "Neli kuningat"

Meie "oma" Unabomber - kes ta on? / Valdek Kiiver

Index Scriptorium Estoniae

Kiiver, Valdek

2005-01-01

1995. a. tabasid USA võimud riiki 17 aastat kirjapommidega terroriseerinud kurjategija, keda kutsuti Unabomberiks. Theodore Kaczynsky (Unabomberi) tegevusest ja tabamisest. Vt. samas: Oklahoma, 1995. Timothy McVeigh kui Oklahoma föderaalkohtuhoones plahvatuse organiseerija

Saared meis ja meie ümber / Katrin Nielsen

Index Scriptorium Estoniae

Nielsen, Katrin

1998-01-01

Chaplini kunstikeskuses 17. detsembrini avatud fotonäitusest 'Põhjala saared', kus oma töid eksponeerisid: Absalon Hansen - Fääri saartest, Göte Ask - Gotlandist, Andy Horner - Ahvenamaalt, ning Tartu kunstikooli fotoeriala tudengid oma pilte Naissaarest, Piirissaarest, Abrukast, Manijast, Vormsist ja Vilsandist.

Maailm Berlinale filmipeeglis. Kus oleme meie? / Annika Koppel

Index Scriptorium Estoniae

Koppel, Annika

2006-01-01

56. Berliini filmifestivali auhinnasaajatest- Kuldkaru saaja bosnialanna Jasmila Zhbavic filmi "Grbavica" eest, režii Hõbekaru saajad britid Michael Winterbottom ja Mat Whitecross filmi eest "Teekond Guatanamosse" ("The Road to Guantanamo"), parima filmi Hõbekaru ja debüüdiauhinna saanud taanlanna Pernille Fischer Christensen filmi "Seep" eest ja iraanlane Jafar Panahi filmi "Suluseis" eest. Parimad näitlejad olid Sandra Hüller ja Moritz Bleibtreu. Eestlased filmiturul. Lisatud nimekiri "56. Berliini rahvusvahelise filmifestivali auhinnad"

Tallinna Tehnikaülikooli Raamatukogu = The Library of the Tallinn University of Technology / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Akadeemia tee 1 / Ehitajate tee 7 asuva raamatukoguhoone arhitektuursest lahendusest. Hoone on projekteerinud arhitektuuribüroo Agabus, Endjärv & Truverk Arhitektid. Žürii liikme Kalle Komissarovi hinnang kultuurkapitali aastapreemiale esitatud hoonele

Zverinõi sharm

Index Scriptorium Estoniae

2004-01-01

Loomaaia sünnipäeval lõpetatakse IV Läänemeremaade animalistliku skulptuuri festival ja selgitatakse võitjad. Osavõtjate loetelu ja žürii koosseis. Eestist osalevad Aleksander Litvinov ja Rafael Danieljants

Vaja on professionaalseid oskusi! / Tiina Lokk ; interv. Maria Ulfsak

Index Scriptorium Estoniae

Lokk, Tiina, 1955-

2004-01-01

Eesti poolt Leedu teleprogrammide ja -filmide festivalil "Amber arch" žüriis osalenud T. Lokk nähtud filmidest ja peapreemia võitnud Priit Valkna dokumentaalfilmist "Hunt", mille tootis Allfilm ETV "Eesti lugude" dokumentaalsarja

Iraani filmimeister ei pääse Berliini festivali žüriisse / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2011-01-01

10.-20. veebruarini toimuva 61. Berliini rahvusvahelise filmifestivali žüriis ei saa osaleda iraani filmirežissöör Jafar Panahi, kellel on kohtuasi pooleli. Rahvusvahelist žüriid juhib Isabella Rossellini

Tallinna Loomeinkubaator = Creative Incubator in Tallinn / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Veerenni 24C asuva Tallinna Loomeinkubaatori sisekujundusest. Sisearhitektid Raul Tiitus, Tarmo Piirmets (Pink OÜ), graafiline kujundus: Kaarel Vahtramäe (Velvet Studio). Žürii liikme Mait Summataveti hinnang kultuurkapitali aastapreemiale esitatud sisekujundusele

Matsalu loodusfilmide festivalist / Mati Kaal, Urmas Tartes

Index Scriptorium Estoniae

Kaal, Mati, 1946-

2006-01-01

Žürii liikmed Matsalu IV Loodusfilmide festivalist, selle programmidest, parematest filmidest. Peapreemia vääriliseks tunnistati režissööride Mark Deeble'i ja Victoria Stone'i film "Puude kuninganna"

Kalamaja põhikooli rekonstrueerimine = Renovation of Kalamaja basic school / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2009-01-01

Tallinnas Vabriku 18 asuva Kalamaja põhikooli hoone (arhitekt Georg Hellat, 1915) muinsuskaitse eritingimused koostas Aleksandr Pantelejev, arhitekt on Andres Põime, sisearhitekt Reet Põime (Studio 3). Žürii hinnang kultuurkapitali aastapreemiale esitatud hoonele

Tartu Kesklinna Kooli juurdeehitus = Addition to Tartu Kesklinna (City Centre) School / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2009-01-01

Juurdeehitise arhitektid Maarja Kask, Ralf Lõoke ja Karli Luik (Salto AB) pälvisid Eesti Kultuurkapitali arhitektuuri sihtkapitali aastapreemia 2008. Muinsuskaitse eritingimused koostas Maret Eimre. Juurdeehitise (Kroonuaia 7) arhitektuursest lahendusest, žürii hinnang

Sotsiaalteadlaste avalik pöördumine

Index Scriptorium Estoniae

2001-01-01

Eesti ühiskond on jõudnud poliitilisse, sotsiaalsesse ja eetilisse kriisi, leiavad oma ühises pöördumises 26 sotsiaalteadlast. Ilmunud ka: Molodjozh Estonii, 23. apr. 2001, lk. 3; Estonija, 24. apr. 2001, lk. 7; Maaleht, 26. apr. 2001, lk. 9; Hiiumaa, 24. apr. 2001, lk. 2; Meie Maa, 24. apr. 2001, lk. 2; Hiiu Leht, 27. apr. 2001, lk. 2

Kas monopoolsete ettevõtete teenuste hinnad on reguleeritavad? / Mai Treial

Index Scriptorium Estoniae

Treial, Mai, 1952-

2001-01-01

Ilmunud ka: Virumaa Teataja, 1. dets. 2001, lk. 11; Tartu : Postimees, 5. dets. 2001, lk. 2; Meie Maa, 4. dets. 2001, lk. 2; Koit, 4. dets. 2001, lk. 6; Valgamaalane, 4. dets. 2001, lk. 2. Peaminister Mart Laarile esitatud arupärimisest monopoolsete ettevõtete kehtestatavate teenuste hindade ja hinnatõusu reguleerimise võimalikkuse kohta ning peaministri antud vastustest. Sotsiaalelektrist. Autor: ERL. Parlamendisaadik

Kogumispension on inimväärse vanaduspõlve jaoks paratamatu / Rein Järvelill

Index Scriptorium Estoniae

Järvelill, Rein, 1966-

2001-01-01

Kolmesambaline pensionisüsteem. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik. Ilmunud ka: Hiiumaa, 8. veebr. 2001, lk. 2; Koit, 10. veebr. 2001, lk. 7; Nädaline, 13. veebr. 2001, lk. 7; Valgamaalane, 13. veebr. 2001, lk. 2; Lääne Elu, 13. veebr. 2001, lk. 4; Järva Teataja, 16. veebr. 2001, lk. 2; Meie Maa, 2. märts 2001, lk. 2

Minister Looduse aeg on otsas / Toivo Tootsen

Index Scriptorium Estoniae

Tootsen, Toivo, 1943-

2001-01-01

Ilmunud ka: Hiiumaa, 31. aug. 2001, lk. 6; Meie Maa, 31. aug. 2001, lk. 2; Kesknädal, 6. sept. 2001, lk. 4; Nädaline, 4. sept. 2001, lk. 5; Sakala, 4. sept. 2001, lk. 2; Nädaline, 4. sept. 2001, lk. 5; Vooremaa, 4. sept. 2001, lk. 2; Virumaa Teataja, 5. sept. 2001, lk. 7. Siseminister peaks tagasi astuma. Autor: Keskerakond. Parlamendisaadik

Eesti riigi regionaalpoliitika ehk Miks elu koondub Tallinna / Taimo Saan

Index Scriptorium Estoniae

Saan, Taimo

2001-01-01

Eesti rahvastik on koondunud Harjumaale, Ida-Virumaale ja Tartumaale. Regionaalpoliitika tasakaalustamise võimalusi. Tabel: Raha jagunemine maakonniti. Ilmunud ka: Severnoje Poberezhje : Subbota, 18. aug. 2001, lk. 2; Hiiu Leht, 24. aug. 2001, lk. 6; Nädaline, 25. aug. 2001, lk. 4; Vooremaa, 28. aug. 2001, lk. 2; Pärnu Postimees, 29. aug. 2001, lk. 2; Meie Maa, 29. aug. 2001, lk. 2

Vaktsineerimine kui hoop Eesti maaelule / Ivari Padar

Index Scriptorium Estoniae

Padar, Ivari, 1965-

2001-01-01

Põllumajandusminister selgitab põllumajandusministeeriumi tegevust Eestit ähvardava suu- ja sõrataudi tõrjumisel. Autor: Rahvaerakond Mõõdukad. Ilmunud ka: Maaleht, 12. apr. 2001, lk. 15; Nädaline, 12. apr. 2001, lk. 4; Meie Maa, 12. apr. 2001, lk. 4; Virumaa Teataja, 11. apr. 2001, lk.7; Vooremaa, 17. apr. 2001, lk. 3; Järva Teataja, 20. apr. 2001, lk. 2