WorldWideScience

Sample records for vice chairman expresses

  1. 39 CFR 4.2 - Vice Chairman.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Vice Chairman. 4.2 Section 4.2 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE OFFICIALS (ARTICLE IV) § 4.2 Vice Chairman. The Vice Chairman is elected by the Governors from among the members of the Board...

  2. Procurement: Government Printing Office Supply of Microfiche to Libraries Disrupted. Report to the Chairman and Vice Chairman of the Joint Committee on Printing, U.S. Congress.

    Science.gov (United States)

    General Accounting Office, Washington, DC. General Government Div.

    In this report, the General Accounting Office (GAO) responds to a July 8, 1988, inquiry by the Chairman and Vice Chairman of the Joint Committee on Printing about the Government Printing Office's (GPO) efforts to acquire and supply microfiche copies of government documents to approximately 1,400 depository libraries. In August 1987, GPO had…

  3. 28 June 2017 - Italian Agnelli Foundation Vice Chairman, and Fiat Chrysler Automobiles Chairman, J. Elkann signing the guest book with CERN Director-General F. Gianotti

    CERN Multimedia

    Bennett, Sophia Elizabeth

    2017-01-01

    from left to right in 53__MA27642: Scuola di Alta Formazione al Management Project manager R. Movva; Agnelli Foundation Director A. Gavosto; Agnelli Foundation Head of Innovation A. Griva; Scuola di Alta Formazione al Management Director S. Pettochi; Agnelli Foundation Vice Chairman, and Fiat Chrysler Automobiles Chairman J. Elkann; CERN Director-General F. Gianotti; Director for International Relations C. Warakaulle; Management Liaison for the Italian Republic, Engineering Department Head R. Losito; Knowledge Transfer Group Leader G. Anelli. Signature of the Framework agreement between the Scuola di Alta Formazione al Management, represented by Director S. Petocchi and CERN, represented by Director-General F. Gianotti, witnessed by Agnelli Foundation Vice Chairman J. Elkann.

  4. Mr Huidong LI Deputy Chairman and Secretary-General, Rev. Committee of Chinese Nationalist Party Vice President, Sun Yat-Sen Culture Interchange Association of China Member, Committee for Internal and Judicial Affairs of the National People's Congress of China

    CERN Multimedia

    Bennett, Sophia Elizabeth

    2017-01-01

    Mr Huidong LI Deputy Chairman and Secretary-General, Rev. Committee of Chinese Nationalist Party Vice President, Sun Yat-Sen Culture Interchange Association of China Member, Committee for Internal and Judicial Affairs of the National People's Congress of China

  5. Hoisting the Sails, Shining the Bright Pearl——Interviewing LiQingPing, Vice Chairman of the Board of International Pearl Jadeite Jewelry Investment Company, General Manager & CEO of Ming Qin Jewelry Group

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Li Qingping was born in Wuning County, Jiangxi Province, in 1954. Now, he is Vice Chairman of the Board of International Pearl, Jadeite and Jewelry Investment Company, General Manager & CEO of Ming Qin Jewelry Group.

  6. 31st August 2011 - Government of Japan R. Chubachi, Executive Member of the Council for Science and Technology Policy, Cabinet Office, Vice Chairman, Representative Corporate Executive Officer and Member of the Board, Sony Corporation, visiting the ATLAS experimental area with Former Collaboration Spokesperson P. Jenni and Senior physicist T. Kondo.

    CERN Multimedia

    Raphaël Piguet

    2011-01-01

    31st August 2011 - Government of Japan R. Chubachi, Executive Member of the Council for Science and Technology Policy, Cabinet Office, Vice Chairman, Representative Corporate Executive Officer and Member of the Board, Sony Corporation, visiting the ATLAS experimental area with Former Collaboration Spokesperson P. Jenni and Senior physicist T. Kondo.

  7. Chairman's welcome

    International Nuclear Information System (INIS)

    Harmon, L.

    1989-01-01

    The author, the director of the Transportation Management Division of the US Department of Energy, serves as the Chairman of this symposium. In his welcome address he discusses the history, progress and problems of the transportation and storage of radioactive materials. He presents a challenge to improve safety through technology

  8. CHAIRMAN'S WELCOME MESSAGE Chairman's message

    Science.gov (United States)

    Oldham, Mark

    2010-11-01

    we were fortunate that many leading speakers shared their experience and perspectives to help achieve these aims. On a more personal note it was a true pleasure to extend a warm welcome to all conference attendees. We have a very diverse group of clinical and research physicists from many parts of the world, and it is truly a pleasure to welcome you all. Finally I would like to acknowledge the many people who have made the meeting possible. Special thanks go to the Scientific Organizing Committee (listed opposite) who reviewed all the conference abstracts and participated in many planning conference calls, and meeting activities. The Local Organizing Committee shouldered a significant load finalizing the conference abstract book and ensuring smooth meeting logistics. We are also very grateful to our sponsors, both academic and industrial, whose support was vital to this meeting. Mark Oldham, PhD, FAAPM Associate Professor, Radiation Oncology and Biomedical Engineering, Duke University Medical Center, Durham, NC, USA mark.oldham@duke.edu Chairman

  9. The chairman's speech

    International Nuclear Information System (INIS)

    Allen, A.M.

    1986-01-01

    The paper contains a transcript of a speech by the chairman of the UKAEA, to mark the publication of the 1985/6 annual report. The topics discussed in the speech include: the Chernobyl accident and its effect on public attitudes to nuclear power, management and disposal of radioactive waste, the operation of UKAEA as a trading fund, and the UKAEA development programmes. The development programmes include work on the following: fast reactor technology, thermal reactors, reactor safety, health and safety aspects of water cooled reactors, the Joint European Torus, and under-lying research. (U.K.)

  10. 19th February 2010: Uppsala University Vice Chancellor A. Hallberg signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci (right) and Uppsala University Professor of Elementary Particle Physics and Chairman of the Swedish LHC Consortium T. Ekelöf.

    CERN Multimedia

    Jean-Claude Gadmer

    2010-01-01

    Other members of the Uppsala University delegation: Vice Rector J.Nordgren; Director A. Fust and Physics Faculty Dean U. Danielsson. Visiting the Superconducting magnet test hall and CTF3 Facility with CLIC Collaboration and Uppsala University R. Ruber; in the ATLAS visitor centre with Collaboration Resources Manager M. Nordberg.

  11. Vice Presidents' Foreword

    Science.gov (United States)

    Dear Reader, In the early sixties, the eminent American hydrologist, Walter Langbein, founded Water Resources Research on behalf of the Section of Hydrology of the American Geophysical Union (AGU). Today, Water Resources Research is undisputed as the leading international journal in its field, and the key factors in its success are: * sustained emphasis on high quality papers; * the reviewing, editing, and management processes are all controlled by the scientists; * the allegiance of the AGU community to WRR; * a verv reasonable cost both to institutions and members; * financial benefits from the sales of the journal are fed back to the AGU, to the benefit of the members. In Europe, we now have a well established community of hydrologists in EGS, and the need for a high quality journal was addressed initially by adopting the already well established Elsevier journal of Hydrology as the official journal of the Hydrological Sciences Section. However, it became apparent that several of the factors associated with WRR's success were not working in the Society's favour, and so it has been decided to establish a new journal which, we hope, can emulate the success of WRR in the fullness of time. Much has been written over the past decade about the need to establish a strong identity for hydrology as a distinct geoscience alongside the atmospheric, ocean and solid earth sciences. The aims and scope of Hydrology and Earth System Sciences (HESS) have been designed to give full expression to this goal, and have been strongly influenced by 'Opportunities in the Hydrologic Sciences' (National Academy Press,1991). The functioning of the hydrological cycle within an earth system undergoing global change is currently the focus of research by many leading scientists and it is hoped that HESS will become a major forum for the publication and discussion of such research, as well as all new findings which enhance the position of hydrology as a geoscience. The success of a new journal

  12. IAEA Board for 2000-2001 elects chairman: Mr. I.H. Umar, Governor of Nigeria

    International Nuclear Information System (INIS)

    2000-01-01

    The document informs about the election of the Governor from Nigeria as Chairman of the IAEA Board of Governors for 2000-2001, and of the Governors from Austria and Poland as Vice-Chairmen. The Member States represented on the IAEA Board for 2000-2001 are also listed

  13. Clinicopathological features and the value of differential Cytokeratin 7 and 20 expression in resolving diagnostic dilemmas of ovarian involvement by colorectal adenocarcinoma and vice-versa

    Directory of Open Access Journals (Sweden)

    Dikshit Rajesh

    2008-09-01

    Full Text Available Abstract The distinction between metastasis from a colorectal adenocarcinoma into the ovary and an ovarian adenocarcinoma is vital, but challenging at times, due to overlapping morphological features. Similarly, a distinction between an ovarian metastasis into the colorectum and a colorectal adenocarcinoma, although rare; is important and can be daunting. We report an analysis of 20 cases of ovarian involvement by metastatic colorectal adenocarcinomas and colorectal involvement by metastatic ovarian adenocarcinomas, including the value of differential expression of cytokeratins 7 & 20 by immunohistochemistry (IHC, in these cases. Nine cases (45% were identified as colorectal adenocarcinomas metastatic to the ovary. On biopsy, all these cases showed a 'garland-like' tumor necrosis, with desmoplasia and predominantly exhibited a tubuloalveolar pattern (67% cases. On IHC, all 8 of 9 such cases, where staining for cytokeratin 20 was performed, displayed strong positivity and 7 cases, where staining for carcinoembryogenic antigen (CEA was performed, revealed positivity for this marker (100%. Other 11 cases (55% were ovarian adenocarcinomas, metastatic to the colorectum. These showed metachronous presentations, with the ovarian tumor preceding the colorectal tumor deposits. Morphologically, psammomatous calcification was noted in 73% of these cases, whereas 'garland-like' necrosis was absent in all. The chief morphological subtype was serous papillary cystadenocarcinoma (55% cases. On IHC, CK7 and CA 125 were positive in all 6 of 11 such cases, whereas CK 20 was negative in all these cases. In cases of complex presentations like an ovarian involvement by a metastatic colorectal adenocarcinoma and vice-versa, certain clinicopathological features are useful. Differential expression of CK 7 and CK20 is vital in resolving these dilemmas. CK20 positivity and CK7 negativity is associated with a colorectal adenocarcinoma. Markers like CEA and CA-125 have an

  14. Vice Presidents' Foreword

    Directory of Open Access Journals (Sweden)

    1997-01-01

    Full Text Available Dear Reader, In the early sixties, the eminent American hydrologist, Walter Langbein, founded Water Resources Research on behalf of the Section of Hydrology of the American Geophysical Union (AGU. Today, Water Resources Research is undisputed as the leading international journal in its field, and the key factors in its success are: * sustained emphasis on high quality papers; * the reviewing, editing, and management processes are all controlled by the scientists; * the allegiance of the AGU community to WRR; * a verv reasonable cost both to institutions and members; * financial benefits from the sales of the journal are fed back to the AGU, to the benefit of the members. In Europe, we now have a well established community of hydrologists in EGS, and the need for a high quality journal was addressed initially by adopting the already well established Elsevier journal of Hydrology as the official journal of the Hydrological Sciences Section. However, it became apparent that several of the factors associated with WRR's success were not working in the Society's favour, and so it has been decided to establish a new journal which, we hope, can emulate the success of WRR in the fullness of time. Much has been written over the past decade about the need to establish a strong identity for hydrology as a distinct geoscience alongside the atmospheric, ocean and solid earth sciences. The aims and scope of Hydrology and Earth System Sciences (HESS have been designed to give full expression to this goal, and have been strongly influenced by 'Opportunities in the Hydrologic Sciences' (National Academy Press,1991. The functioning of the hydrological cycle within an earth system undergoing global change is currently the focus of research by many leading scientists and it is hoped that HESS will become a major forum for the publication and discussion of such research, as well as all new findings which enhance the position of hydrology as a geoscience. The success

  15. 75 FR 51292 - Before Commissioners: Ruth Y. Goldway, Chairman; Tony L. Hammond, Vice Chairman; Mark Acton; Dan...

    Science.gov (United States)

    2010-08-19

    ... Service requested to have the contract in Docket No. CP2010-71 serve as the baseline contract for future... reasons why the instant GEPS 3 contracts fit within the Mail Classification Schedule language for GEPS... that ``[b]ecause the agreements incorporate the same cost attributes and methodology, the relevant...

  16. 39 CFR 4.1 - Chairman.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Chairman. 4.1 Section 4.1 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE OFFICIALS (ARTICLE IV) § 4.1 Chairman. (a) The Chairman of the Board of Governors is elected by the Governors from among the members of...

  17. 47 CFR 0.211 - Chairman.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Chairman. 0.211 Section 0.211 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Delegations of Authority Commissioners § 0.211 Chairman. The responsibility for the general administration of internal affairs of the...

  18. ACHP | News | President Appoints Clement A. Price Vice Chairman of ACHP

    Science.gov (United States)

    appreciation of the nation's diverse cultural heritage will be greatly aided by Dr. Price's expertise." Jersey in 1999. In 2008 Price received the second annual Charles Cummings award from the Trustees of the contributions to the knowledge and appreciation of Newark history. Price will receive the oath of office and

  19. Message from Vice-Chancellor

    Science.gov (United States)

    Nasir Ibrahim, Daing

    2013-12-01

    Salam Malaysia! First and foremost, I want to thank all 2nd International Conference on Mechanical Engineering Research (ICMER 2013) organisers for inviting me to address and officiate this conference. This 2nd ICMER 2013 provides a platform to bring together not only researchers, postgraduate students but also industrial people. With this platform, ICMER will embark on a whole process of making new discoveries and then translating them into products and services for the marketplace and this is only made possible with people like all of you. I would like to congratulate the ICMER 2013 organisers for the achievement of collecting 208 papers for this conference. Submissions received from 17 local universities, 7 industrial companies and 9 different countries is a great achievement for UMP. I am very happy to welcome all of you from Malaysia, Iran, Turkey, Japan, India, Australia, Ireland, Saudi Arabia and Bangladesh to this conference. As one of Malaysia's Public Universities, UMP's main challenge is to remain competitive and relevant by offering high quality technical academic programmes and research activities, focusing on its niche areas. New knowledge and findings cannot be generated without any research and development (R&D) activities. These efforts will undoubtedly generate lots of interesting results and new knowledge either bring further commercialisation activities. The Malaysian government has invested a huge sum of Ringgits in R&D over the years. Therefore, UMP must produce more quality researchers and graduates to ensure Malaysia reaps the returns from these investments vice versa of progressive economic growth for the country. UMP's 2011-2015 Strategic Plan determines to strengthen and sustained its financial support by allocating research grants and industry collaboration and consultations through its business and commercial unit. On behalf of UMP, I would like to express my appreciation to all committee members of ICMER 2013 from Faculty of Mechanical

  20. Biggert named chairman of energy subcommittee

    CERN Multimedia

    2003-01-01

    U.S. Representative Judy Biggert has been named Chairman of the Energy Subcommittee of the House Science Committee, a key panel with jurisdiction over the federal government's civilian energy and science research activities, including the work done at Argonne and Fermilab (1 page).

  1. No Evidence That Communications Between the FERC Chairman and the Chairman of Enron Corporation Violated Criminal Statutes or Ethics Regulations

    National Research Council Canada - National Science Library

    Hast, Robert

    2001-01-01

    ...., Chairman of the Federal Energy Regulatory Commission (FERC) and Kenneth Lay, Chairman of Enron Corporation, who were the subjects of an article published in The New York Times on May 25, 2001...

  2. Message from Vice Chancellor, UMP

    Science.gov (United States)

    Nasir Ibrahim, Daing

    2012-09-01

    progressive economic growth for the country. Commensurate with these efforts, the results of research must be commercialised effectively. That is why our 2nd KRA UMP's 2011-2015 Strategic Plan determines that we strengthen and sustain its financial support by allocating research grants and industry collaboration and consultations through its business and commercialisation unit. Commercialisation of research outcomes doesn't happen naturally. It may need many man-hours and effort to be invested rather than just purchasing new tools and equipment for laboratories. Moreover, it would be unfortunate if many research results remain in the form of technical publications and scientific journals rather than actual products. These may of course be valuable in their own right but the impact on society and economies must be the main agenda and one of the objectives of the research. The process of taking technology from laboratories to the marketplace will face challenges and pitfalls. In that case we as researchers must be responsible and willing to create a supportive environment for those who undertake this risky business of commercialising R&D especially for innovative entrepreneurship that carries out a new technological approach out from the laboratories to high-tech ventures. We have achieved many accolades from numerous competitors since we first embarked on our journey to make R&D activities play a more significant role in the economy in Malaysia. Therefore, we must keep up the pace of this journey and maintain our investment in R&D despite facing the unfavourable global financial situation because ultimately we must to remain a top and competitive player in the global economy. This can be done by continuing to produce high quality research and technology which will set a milestone in transforming our economy. On behalf of UMP, I would like to express my appreciation to the all the committee members from the Faculty of Mechanical Engineering and Automotive Engineering Centre for

  3. ARCO Chairman forecasts end of oil dominance

    Science.gov (United States)

    Showstack, Randy

    The head of one of the world's biggest oil companies said in February that the era of oil dominating the global energy market is creaking to a close. Future energy needs will be met by a mix of fuels that are less harmful to the environment, he said, and he called for the energy and automobile industries to collaborate on solutions to reduce emissions.“We've embarked on the beginning of the last days of the age of oil,” ARCO Chairman Mike Bowlin said at a Cambridge Energy Research Associates conference in Houston, Texas, where he also described how ARCO is moving toward a new energy model. “Our challenge is not merely to survive today's low prices, but to plan for a future in which hydrocarbons are just one of a wide variety of clean fuels that will build the global economy of the 21st century”.

  4. Farewell interview with NRC Chairman Rowden

    International Nuclear Information System (INIS)

    Hill, R.L.

    1977-01-01

    Marcus Rowden, former chairman, shares his concerns for the future of the Nuclear Regulatory Commission under the new Department of Energy (DOE). He is hopeful that a constructive relationship between the two will allow nuclear development to proceed efficiently, but with the independent regulation needed to reassure public fears. He stresses the need for regional planning and licensing reform that will improve the licensing process. Risk assessments need to be made that are relative to the risks of other energy sources. Decisions on nuclear waste disposal and power plant security are national in scope and should be made by a single body which has listened to all points of view. Resignations over regulatory decisions indicate that the system is neither perfect nor monolithic, but allows dissenting voices to be heard

  5. Journal of Glenn T. Seaborg, Chairman of the US Atomic Energy Commission, 1961--1971

    International Nuclear Information System (INIS)

    Seaborg, G.T.

    1989-01-01

    This introduction to my journal of 1961--1971, covering my years of service as Chairman of the US Atomic Energy Commission, is written from the perspective of 1971, in order to reflect the attitudes expressed in my journal, which was written on a daily basis during that period. Thus, I express the points of view of that time rather than those of today (1988), which might occasionally be somewhat different. The journal consists of 25 volumes, averaging 700 pages each. This comprises about 15,000 items consisting of the approximately 4000 daily entries and the average of about three attachments per day. The journal has three sections corresponding to each of the three presidents I served as chairman of the Atomic Energy Commission -- the first six volumes covering the John F. Kennedy years (February 1, 1961--November 22, 1963), the next 11 volumes covering the Lyndon B. Johnson years (November 22, 1963--January 20, 1969) and the final eight volumes, the Richard M. Nixon years and a few months of post-AEC chairman activities in Washington (January 20, 1969--November 6, 1971.)

  6. CERN welcomes the Spanish Vice-President

    CERN Multimedia

    Anaïs Schaeffer

    2015-01-01

    On 29 September, CERN had the pleasure of welcoming the Vice-President of the Government of Spain, Soraya Sáenz de Santamaría, for a visit of the Laboratory.   From left to right: Lluis Miralles (Head of the General Infrastructure Services department), Soraya Sáenz de Santamaría (Vice-President of the Government of Spain) and José Miguel Jiménez (Head of the Technology department).   The Vice-President was accompanied by Carmen Vela, Spanish Secretary of State for Research, Development and Innovation, Bernardo de Sicart Escoda, Ambassador of Spain to Switzerland, and Ana Menéndez Pérez, Permanent Representative of Spain to the United Nations and International Organizations in Geneva. Their tour started at LHC Point 1, where CERN Director-General Rolf Heuer welcomed them and gave them an introduction to CERN's activities. Jos&ea...

  7. 7 CFR 2.72 - Chairman, World Agricultural Outlook Board.

    Science.gov (United States)

    2010-01-01

    ... OF AGRICULTURE AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Chief Economist... (a)(7), the following delegations of authority are made by the Chief Economist to the Chairman, World... following authority is reserved to the Chief Economist: Review all proposed decisions having substantial...

  8. 17 CFR 200.16 - Executive Assistant to the Chairman.

    Science.gov (United States)

    2010-04-01

    ... of the laws and its relations with the public, industry, and the Congress. The Executive Assistant is... Commission, members of the staff, and/or representatives of the public on matters arising with regard to... cases in which the Chairman or the General Counsel has determined that separation of functions...

  9. The SIP express router: An open source SIP platform: Presentation held at EVOLUTE - seamlEss multimedia serVices Over alL IP-based infrastrUcTurEs Workshop, 10. November 2003, Guildford, UK

    OpenAIRE

    Rebahi, Y.; Sisalem, D.; Kuthan, J.; Pelinescu-Oncicul, A.; Iancu, B.; Janak, J.; Mierla, D.C.

    2003-01-01

    The session initiation protocol (SIP) is constantly gaining in popularity and acceptance as the signaling protocol for next generation multimedia communication. This paper describes a scalable and reliable open source SIP platform called the SIP Express Router (SER). SER does not only support basic SIP features but also advanced features such as messaging and presence, translation between SIP and SMS or Jabber as well as full featured application programming interfaces. In this paper we will ...

  10. Interview with Pennsylvania PUC chairman Susan M. Shanaman

    International Nuclear Information System (INIS)

    Utroska, D.

    1981-01-01

    Chairman Shanaman notes that Pennsylvania law justifies the Public Utility Commission (PUC) refusal to charge ratepayers for the cost of Three Mile Island units 1 and 2, neither of which are providing service, because ratepayers are already paying the costs of replacement power. The PUC chairman points to other service territories around the country where rates are kept below national averages because the average income level is low. The Metropolitan Edison Company is seeking Federal relief as well as legislative permission to put TMI-1 back into the rate base in fairness to ratepayers, but the PUC does not see bankruptcy for the utility as an appropriate way to force Federal assistance. The Administration needs to understand the local impact of Federal policies, especially those which are incompatible with state situations. Appropriate involvement includes nuclear waste research and underwriting some of the cleanup costs of onsite accidents that are too large for a single utility to handle. Chairman Shanaman feels that ratepayers should contribute to the insurance premium for future accidents, but not retroactively to support TMI-2. Nuclear power plant construction in the US will not progress until the issues of TMI-2 are resolved

  11. Journal of Glenn T. Seaborg (Chairman, US Atomic Energy Commission, 1961 through 1971), July 1, 1961--December 31, 1961

    International Nuclear Information System (INIS)

    Seaborg, G.T.

    1989-01-01

    This introduction to my journal of 1961--1971, covering my years of service as Chairman of the US Atomic Energy Commission, is written from the perspective of 1971, in order to reflect the attitudes expressed in my journal, which was written on a daily basis during that period. Thus, I express the points of view of that time rather than those of today (1988), which might occasionally be somewhat different. The journal consists of 25 volumes, averaging 700 pages each. This comprises about 15,000 items consisting of the approximately 4,000 daily journal entries and the average of about three attachments per day. The journal has three sections corresponding to each of the three presidents I served as chairman of the Atomic Energy Commission -- the first six volumes covering the John F. Kennedy years (February 1, 1961--November 22, 1963), the next 11 volumes covering the Lyndon B. Johnson years (November 22, 1963--January 20, 1969) and the final eight volumes, the Richard M. Nixon years and a few months of post-AEC chairman activities in Washington (January 20, 1969--November 6, 1971)

  12. 22 CFR 40.24 - Prostitution and commercialized vice.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Prostitution and commercialized vice. 40.24... Certain Crimes § 40.24 Prostitution and commercialized vice. (a) Activities within 10 years preceding visa... United States solely, principally, or incidentally to engage in prostitution, or has engaged in...

  13. The Vices of Economists; The Virtues of the Bourgeoisie

    NARCIS (Netherlands)

    McCloskey, Deirdre N.

    1997-01-01

    The 'vices' are three bad habits into which economists have fallen over the past fifty years: bad statistics, bad theory, and bad applications of statistics and theory to public affairs. This book details the vices, tracing them to the influence of three giants of the 1940s and 1950s in economics,

  14. Markel senior vice president to give Wachovia Lecture

    OpenAIRE

    Ho, Sookhan

    2008-01-01

    Markel Corporation's senior vice president and chief financial officer Richard R. Whitt will give a talk on Thursday, Nov. 13, as the Wachovia Distinguished Speaker in the Pamplin College of Business.

  15. Vices Among Commercial Chickens in Maiduguri, Borno State ...

    African Journals Online (AJOL)

    Vices Among Commercial Chickens in Maiduguri, Borno State: Causes and Possible Intervention Strategies. ... Journal Home > Vol 8, No 2 (2009) > ... interviews with the farm managers and farm owners were employed for data collection.

  16. Executive Assistant to the Vice-President, Corporate Strategy and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Job Summary Under the direction of the Vice-President, Corporate Strategy and ... between the Corporate Strategy and Communications Management sides of the team. ... Maintains personnel and human resources records for the Division.

  17. More growth and change in sight, chairman says

    International Nuclear Information System (INIS)

    Share, J.

    1997-01-01

    Nearly every day it seems that Enron Corp. adds still another project to its already far-flung energy portfolio, be it a pipeline in Argentina, LNG in Oman, or power plants in Poland, Mozambique, the Philippines, Vietnam and India. Divided into five divisions, Enron Oil and Gas Co., (EOG), Enron International (EI), Enron Capital and Trade Resources Corp. (ECT), enron Ventures Corp. (EVC), and Enron Gas Pipeline Group (GPG), it's GPC that is the nerve center of the multi-billion-dollar natural gas/electricity empire. Pipeline and Gas Journal examines GPG as part of a series beginning with a wide-ranging interview with Stanley C. Horton, chairman and CEO of Enron GPG, who discusses corporate strategy including the pipeline construction market and the unprecedented restructuring that will forever change the way industry does business

  18. New FERC chairman says plenty of activity yet to come

    International Nuclear Information System (INIS)

    Share, J.

    1997-01-01

    Utility executives may have slowed their merger and acquisition activity to catch their breath, but it's far from over, says Jim Hoecker, the new chairman of the Federal Energy Regulatory Commission. He doesn't think we've seen the last of this phenomenon. As the industry begins to understand the shape of market developments to come in the future, increasingly creative M and A activities will be seen. But there's also many other contractual arrangements among utilities and between utilities, pipelines, and gas distribution companies that reflect the more dynamic market of today. In the interview, he referred to a survey of utility executives in which as many as 45% indicated that their companies were involved in merger or acquisition activity. That survey found about 70% of these executives felt there is going to be more consolidation within the utility industry and an even larger proportion concluded there would be increased mergers between the electric and natural gas industries. In addition, Hoecker discusses gas versus electric, gas versus coal, and FERC's future

  19. Student Town Meeting with Vice President Al Gore. Teacher's Guide.

    Science.gov (United States)

    Edwards, Amy N.

    This teacher's guide accompanies a videotape of the same name. Vice President Albert Gore, Jr., discusses current issues with students who question Mr. Gore on such topics as the environment, reinventing government, voter participation, crime, and the United States' role in foreign affairs. Gore tailors his answers to the teenage audience as the…

  20. 2016-2017 Hospitality Expense Reports for Sylvain Dufour, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Chantal Taylor

    Lunch during the Annual Resources Branch Management-Regional. Directors Meeting. Date: 2016-11-16. Attendees: 20 (IDRC 19). Location: Ottawa. Total: $814.00. Comments: 2016-2017 Hospitality Expense Reports for. Sylvain Dufour, Vice-President, Resources, and. Chief Financial Officer.

  1. 2016-2017 Travel Expense Reports for Sylvain Dufour, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Beata Bialic

    Date(s):. 2016-10-15 to 2016-10-21. Destination(s):. Orlando, FL (USA). Airfare: $497.01. Other. Transportation: $181.22. Accommodation: $1,216.70. Meals and. Incidentals: $853.72. Other: $53.05. Total: $2,801.70. Comments: 2016-2017 Travel Expense Reports for Sylvain. Dufour, Vice-President, Resources, and Chief.

  2. 2016-2017 Hospitality Expense Reports for Sylvain Dufour, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Chantal Taylor

    Resources Branch Management lunch during annual evaluation meeting of RB personnel. Date: 2016-05-04. Attendees: 7 (IDRC 7). Location: Ottawa. Total: $160.50. Comments: 2016-2017 Hospitality Expense Reports for. Sylvain Dufour, Vice-President, Resources, and. Chief Financial Officer.

  3. 2017-2018 Travel Expense Reports for Joanne Charette, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    BB

    2017-06-11 to 2017-06-14. Destination(s):. Montreal. Airfare: $0.00. Other. Transportation: $170.23. Accommodation: $793.75. Meals and. Incidentals: $103.67. Other: $0.00. Total: $1,067.65. Comments: 2017-2018 Travel Expense Reports for Joanne. Charette, Vice-President, Corporate Strategy and Communications.

  4. RTE - Report by the Chairman of the Supervisory Board 2016

    International Nuclear Information System (INIS)

    2017-01-01

    The Chairman of the Supervisory Board of RTE (Reseau de Transport d'Electricite) draws up and publishes an annual report on corporate governance and internal control procedures, in application of Paragraph 7 of Article L. 225-68 of French company law (Code de Commerce). This is a requirement on companies whose shares are traded on a regulated market, as is the case of RTE. Paragraph 7 of Article L. 225-68 of French company law (Code de Commerce) stipulates that the report must present: the composition of the Supervisory Board and the application of the principle of equal representation of men and women, the conditions of preparing and organising the work of the Supervisory Board, internal control and risk management procedures implemented by the company, the corporate governance code to which the company adheres. Additionally, this report must set out: the principles for determining the remuneration of senior executives, specific provisions relating to the involvement of shareholders at the General Meeting of Shareholders. Within RTE, this report has been prepared by the Legal Affairs Department, which directed a work team. They reported on the functioning of the Supervisory Board and the implementation of internal control and risk management procedures, both for RTE and for its subsidiaries. The present report was approved by the Executive Board and was submitted to the Statutory Auditors. It was then presented to the Economic and Audit Supervisory Committee on 07 February 2017 and the Supervisory Board on 09 February 2017. The report was published at the same time as the activity report, the management report and consolidated accounts, annual accounts and the sustainability report. This document takes account of the various recommendations published by the French Financial Markets Authority (AMF)

  5. Will Higher Education Pass "A Test of Leadership"? An Interview with Spellings Commission Chairman Charles Miller

    Science.gov (United States)

    Callan, Pat

    2007-01-01

    Charles Miller, former chairman of the University of Texas System's Board of Regents, chaired the recent Commission on the Future of Higher Education created by Secretary of Education Margaret Spellings. Here he is interviewed regarding the panel's widely discussed report, "A Test of Leadership," by Pat Callan, president of the National…

  6. Open Letter from the GAC-EPA to the Chairman of the PFGB EPA

    CERN Multimedia

    GAC-EPA

    2012-01-01

    Following the publication by the Chairman of the Pension Fund Governing Board of  the Spring report of the Pension Fund in the CERN Bulletin issue dated 25 July 2012 (Nos 30 & 31), the GAC-EPA has reacted through an open letter. See www.gac-epa.org under Announcement.

  7. DefenseLink Feature: Navy Adm. Mike Mullen, New Chairman Lays Out Top

    Science.gov (United States)

    global risk to help us maintain a position of leadership and preserve our freedom of action to counter , Oct. 26, 2007 - In his first public speech as chairman of the Joint Chiefs of Staff, Navy Adm. Michael Posts About This Site DoD Inspector General Freedom of Information Privacy & Security External Link

  8. Role Conflict in Academic Organizations: An Exploratory Examination of the Department Chairman's Experience

    Science.gov (United States)

    Carroll, Archie B.

    1974-01-01

    A probe was made into the relationship between perceived role conflict and focal person satisfaction, as measured by the reported need deficiency of university department chairmen. Additionally, six key decision areas were examined exploring the existence of role conflict in departmental chairman decisionmaking. (Author)

  9. Hydrologic Regulation of Plant Rooting Depth and Vice Versa

    Science.gov (United States)

    Fan, Y.; Miguez-Macho, G.

    2017-12-01

    How deep plant roots go and why may hold the answer to several questions regarding the co-evolution of terrestrial life and its environment. In this talk we explore how plant rooting depth responds to the hydrologic plumbing system in the soil/regolith/bedrocks, and vice versa. Through analyzing 2200 root observations of >1000 species along biotic (life form, genus) and abiotic (precipitation, soil, drainage) gradients, we found strong sensitivities of rooting depth to local soil water profiles determined by precipitation infiltration depth from the top (reflecting climate and soil), and groundwater table depth from below (reflecting topography-driven land drainage). In well-drained uplands, rooting depth follows infiltration depth; in waterlogged lowlands, roots stay shallow avoiding oxygen stress below the water table; in between, high productivity and drought can send roots many meters down to groundwater capillary fringe. We explore the global significance of this framework using an inverse model, and the implications to the coevolution of deep roots and the CZ in the Early-Mid Devonian when plants colonized the upland environments.

  10. Wisdom teeth: mankind's future third vice-teeth?

    Science.gov (United States)

    Zou, DuoHong; Zhao, Jun; Ding, WangHui; Xia, LunGuo; Jang, XinQuan; Huang, YuanLiang

    2010-01-01

    The third molar teeth (wisdom teeth) represent the last eruption of the teeth in the human dentition. Throughout evolution, the mandible has had a tendency to decrease in size; the third molar teeth are often impacted, resulting in incomplete tooth eruption that often causes clinical pericoronitis, dental caries, and pericemental abscess. Therefore, the wisdom teeth are often extracted. Moreover, wisdom teeth are often removed for clinical orthodontic treatment. On the other hand, tooth loss due to periodontal disease, dental caries, trauma, or a variety of genetic disorders continues to affect people's lives. Autologous tissues for dental tissue regeneration that could replace lost teeth could provide a vital alternative to currently available clinical treatments. To pursue this goal, we hypothesize that human third molar tooth buds can be obtained during development. Human wisdom tooth germination tissue could then be placed into an embryonic stem cell bank for storage. When the donor's other teeth are missing, embryonic stem cell and tissue engineering technologies, will permit the restoration of the missing teeth. Therefore wisdom teeth will be mankind's future third vice-teeth.

  11. Conversion of radius of curvature to power (and vice versa)

    Science.gov (United States)

    Wickenhagen, Sven; Endo, Kazumasa; Fuchs, Ulrike; Youngworth, Richard N.; Kiontke, Sven R.

    2015-09-01

    Manufacturing optical components relies on good measurements and specifications. One of the most precise measurements routinely required is the form accuracy. In practice, form deviation from the ideal surface is effectively low frequency errors, where the form error most often accounts for no more than a few undulations across a surface. These types of errors are measured in a variety of ways including interferometry and tactile methods like profilometry, with the latter often being employed for aspheres and general surface shapes such as freeforms. This paper provides a basis for a correct description of power and radius of curvature tolerances, including best practices and calculating the power value with respect to the radius deviation (and vice versa) of the surface form. A consistent definition of the sagitta is presented, along with different cases in manufacturing that are of interest to fabricators and designers. The results make clear how the definitions and results should be documented, for all measurement setups. Relationships between power and radius of curvature are shown that allow specifying the preferred metric based on final accuracy and measurement method. Results shown include all necessary equations for conversion to give optical designers and manufacturers a consistent and robust basis for decision-making. The paper also gives guidance on preferred methods for different scenarios for surface types, accuracy required, and metrology methods employed.

  12. The Possibility of Vice-Presidents’ Authority Arrangement in the 1945 Constitution through Constitutional Amendment

    Directory of Open Access Journals (Sweden)

    Fajar L. Suroso

    2016-04-01

    Full Text Available The debate over the vice-presidents’ authority reappeared in the administration of President Jokowi after the “authority expansion of the Chief of Presidency Staff” and the case of “Rizal Ramli vs Jusuf Kalla”. This article is intended to provide arguments for the idea of some parties to organize more explicit and detailed the authority of vice-president in the 1945 Constitution. The idea arises from the absence of further arrangement on the authority of vice-president in the 1945 Constitution. This article is systematized into 3 (three sub-theme; 1 the arrangement of the vice-presidents’ authority in the constitution for several countries; 2 The authority of the vice-president according to the 1945 Constitution, and 3 New resultant and the possibility of 1945 Constitution amendment. The result revealed a number of interesting things; 1 the constitutions of other countries do not specify the authority of the vice-president and put the vice-president as a “spare tire” when the president is absent; 2 no new resultant about the position and authority of the vice-president so that theoretically is not reason enough to regulate in detail the authority of the vice-president through the 1945 Constitution amendment; 3 arrangement in detail in the authority of vice-president in the 1945 Constitution holds the potential to confuse the presidential system design as the 1945 Constitution. Therefore, the possibility of vice-presidents’ authority arrangement in the 1945 Constitution through amendment is very small, both in terms of momentum and the substance of issues.

  13. Budgetary and Economic Outcomes Under Paths for Federal Revenues and Noninterest Spending Specified by Chairman Price, March 2016

    Science.gov (United States)

    2016-03-01

    Budgetary and Economic Outcomes Under Paths for Federal Revenues and Noninterest Spending Specified by Chairman Price , March 2016 March 2016CONGRESS... Price and His Staff 1 The Extended Baseline and Three Illustrative Paths 1 How CBO Analyzed the Effects of the Budgetary Paths 3 What Would Outcomes...Be Under Current Law? 4 What Paths for Federal Revenues and Noninterest Spending Did Chairman Price Specify? 6 What Would Budgetary and Economic

  14. Developing Virtue and Rehabilitating Vice: Worries about Self-Cultivation and Self-Reform

    Science.gov (United States)

    Battaly, Heather

    2016-01-01

    Aristotelian virtue theorists have emphasized the role of the self in developing virtue and in rehabilitating vice. But this article argues that, as Aristotelians, we have placed too much emphasis on self-cultivation and self-reform. Self-cultivation is not required for developing virtue or vice. Nor will "sophia"-inspired self-reform…

  15. Chairman's address

    International Nuclear Information System (INIS)

    Foster, J.S.

    1981-06-01

    There is no intrinsic demand for energy separable from supply; the demand for a resource reflects its availability. The Conservation Commission of the World Energy Conference used one study that predicted that if economic growth rates were to remain comparable to those of the last forty years, eight times the 1975 level of energy supply would be required by 2020. An alternative view suggested that if the income elasticity for energy declined with increasing economic development, there would be a fourfold increase in energy demand by 2020. Energy supply today and what it might be in 40 years is examined. The energy use of biomass will probably increase in certain areas of the world, but it is unlikely that there will be an overall growth in supply from this source. Energy production from fossil fuels may double between now and the early years of the next century, but unless the recovery rate of coal is increased drastically, growth will peak by mid-century. Hydro-electric and geothermal power may quadruple over the next forty years, but this will not represent a big increase in supply. Solar energy can make only a modest contribution in the next few decades. If there is to be a major increase in world energy supply, it must come from nuclear energy. The Conservation Commission felt that the potential for world energy supply is doubling between 1980 and 2000, and a further 50 percent growth to 2020. There will most likely be a 50 percent growth in per capita energy use around the world, with 3 to 4 percent annual growth rate in developing countries and perhaps the same in industrialized countries for the first 20 years, but about half that growth rate towards the end of the time period

  16. The lasting impression of chairman Mao: hyperfidelity of familiar-face memory.

    Science.gov (United States)

    Ge, Liezhong; Luo, Jing; Nishimura, Mayu; Lee, Kang

    2003-01-01

    We examined the accuracy of a highly-familiar-face representation in memory. In experiment 1, a famous portrait of Chairman Mao was digitally altered in terms of the distance between his two eyes, two pixels at a time. Mainland Chinese adults were shown the original or altered photos, one at a time, and asked to determine whether each was that of Chairman Mao or altered. Eastern Asian and Caucasian participants, who were unfamiliar with Mao's photo, were shown simultaneously the original face paired with the altered ones and asked to determine whether the photos were identical. The Mainland Chinese participants' memory threshold approximated the perceptual discrimination threshold of the Eastern Asian and Caucasian participants. Experiments 2 and 3 ruled out that the result of experiment I was due to artifacts of photographic alteration. The findings of the present study suggest that our memory of a very familiar face is highly accurate, at least in terms of the interocular configuration. The accuracy is perhaps only limited by the perceptual resolution capacity of our visual system.

  17. 2017-2018 Hospitality Expense Reports for Stephen McGurk, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    SD

    Description: Lunch - Development research issues. Date: 2017-05-30. Attendees: 2 (IDRC 1). Location: Nairobi, Kenya. Total: $12.10. Comments: 2017-2018 Hospitality Expense Reports for. Stephen McGurk, Vice-President, Program and Partnership Branch.

  18. 27 October 2014 - L. Pistelli Vice Minister at Foreign Affairs and International Cooperation, Italian Republic

    CERN Multimedia

    Guillaume, Jeanneret

    2014-01-01

    Mr Lapo Pistelli Vice Minister at Foreign Affairs and International Cooperation, Member of the Italian Parliament (Chamber of Deputies), Italian Republic, signing the Guest Book with CERN Director-General R. Heuer ; Physics Department Head L. Mapelli also present

  19. 2016-2017 Hospitality Expense Reports for Stephen McGurk, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Beata Bialic

    Description: Lunch to discuss IDRC programming. Date: 2016-10-04. Attendees: 2 (IDRC 1). Location: Ottawa. Total: $25.99. Comments: 2016-2017 Hospitality Expense Reports for. Stephen McGurk, Vice-President, Programs and Partnership Branch.

  20. Scientific production of Vice Chancellors for Research in Peruvian universities with a medical school.

    Science.gov (United States)

    Herrera-Añazco, Percy; Valenzuela-Rodríguez, Germán; Pacheco-Mendoza, Josmel; Málaga, Germán

    2017-10-19

    To determine the scientific production of Research Vice-chancellors at Peruvian universities that have medical schools, as well as their academic degrees as an indirect way to evaluate their suitability for the position they hold. We searched all Peruvian universities that register medical schools. Of these, the scientific production of the universities registered in SCOPUS was identified in September of the 2016. The scientific production of the vice chancellors of investigation of these faculties of medicine was determined through the search of its scientific publications registered in SCOPUS and those reported in the National Registry of Researchers in Science and Technology. Academic degrees were obtained from the database of the National Superintendence of Higher University Education. The sample included 28 research vice chancellors. Only 4/28 had any publications. The average number of articles published by the vice chancellors of research was 1.71, the number of citations 23.1 on average and the H index 0.64. Besides, 22 Vice-chancellors of research had the degree of doctor, four had the degree of bachelor and two the degree of master. The scientific production of research vice chancellors is poor. The required academic grade requirement for the position is not met in all cases. It is likely that, having no research experience, his leadership in directing a university's research policies may be questioned.

  1. Journal of Glenn T. Seaborg, Chairman of the US Atomic Energy Commission, 1961--1971

    International Nuclear Information System (INIS)

    Seaborg, G.T.

    1989-12-01

    This book contains a very limited sampling of press clippings from my tenure as Chaiman of the Atomic Energy Commission (1961--1971). A more complete collection of these has been deposited with the Manuscript Division of the Library of Congress. This serves as an appendix to the Journal of Glenn T. Seaborg, Chairman of the Atomic Energy Commission, 1961--1971, which has been printed by the Lawrence Berkeley Laboratory in 25 volumes. Copies of this 25-volume daily journal have been deposited at the Lawrence Berkeley Laboratory, the Bancroft Library of the University of California at Berkeley, the University of California at Los Angeles Main Library, the University of California at Santa Barbara, the National Archives, the Library of Congress, and the presidential libraries of Kennedy, Johnson and Nixon

  2. National Geographic Education. An Interview with Gilbert M. Grosvenor, President and Chairman of the Board, National Geographic Society.

    Science.gov (United States)

    Jumper, Sidney R.

    1991-01-01

    Presents an interview with Gilbert Grosvenor, president and chairman of the board of the National Geographic Society. Examines student and public ignorance about geography. Describes the Society's Geography Education Project, Geographic Alliance Project, and Education Foundation. Includes Grosvenor's call for greater emphasis on geography in…

  3. Expression

    Directory of Open Access Journals (Sweden)

    Wang-Xia Wang

    2014-02-01

    Full Text Available The miR-15/107 family comprises a group of 10 paralogous microRNAs (miRNAs, sharing a 5′ AGCAGC sequence. These miRNAs have overlapping targets. In order to characterize the expression of miR-15/107 family miRNAs, we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members, and other selected miRNAs, in 11 human tissues obtained at autopsy including the cerebral cortex, frontal cortex, primary visual cortex, thalamus, heart, lung, liver, kidney, spleen, stomach and skeletal muscle. miR-103, miR-195 and miR-497 were expressed at similar levels across various tissues, whereas miR-107 is enriched in brain samples. We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations (enriched for cortical neurons, astrocytes and microglia, respectively. In primary cultures of rat brain cells, several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system (CNS. In addition to mature miRNAs, we also examined the expression of precursors (pri-miRNAs. Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors. In summary, we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes.

  4. VICE PRESIDENT TASKS AND AUTHORITIES IN THE CONSTITUTIONAL SYSTEM OF THE REPUBLIC OF INDONESIA UNDER 1945 CONSTITUTION

    Directory of Open Access Journals (Sweden)

    Melan Yusuf Nomleni

    2017-02-01

    Full Text Available The amendment of Constitution has not met the the life of the nation’s demand, one of which is the  of the tasks and authorities of the Vice President. This sparks multiple interpretations on the role and its legal implications toward the responsibility over the Vice President tasks and. The results show several reasons underlying obscurity of the tasks and authorities regulation of the Indonesian Vice President stated in 1945 Constitution, among which is the Indonesian governance. The obscure regulation of the Vice President tasks and authorities affects on his/her responsibility. Hence, the clear regulation related to the tasks and authorities of the Vice President as President Assistant in performing state governance is required. Keywords : Regulation, Vice President, Authorities

  5. The modern surgery department chairman: the job description as identified by chairmen.

    Science.gov (United States)

    Slakey, Douglas P; Korndorffer, James R; Long, Kira N; Clark, Tyler; Hidalgo, Marco

    2013-06-01

    The role of the chairman of a surgery department is critical in academic surgery. However, little is known about the variability of job responsibilities. To evaluate chairmen's responsibilities, methods of support, determinants of job performance success, and concerns. Internet-based survey. Electronic survey system. Seventy-two chairmen. Survey data on job responsibilities, methods of support, determinants of job performance success, and concerns. Of 168 chairmen who received the survey, 72 (43%) responded. The mean age of chairmen was 57 years (range, 44-78 years). Of 72 chairmen who responded, 69 (96%) were men, 67 (93%) were white, 65 (90%) were professors, 11 (15%) held a previous chair, 35 (49%) have advanced degrees, and 19 (26%) are program directors. Respondents are responsible for an average of 8.7 divisions, 60 (83%) spent 1 to 10 hours per week in the clinic, 45 (63%) performed surgery 1 to 10 hours per week, 54 (75%) took less than 6 call days per month, 44 (61%) published 1 to 6 papers per year and attended a mean (SD) of 4.3 (1.7) essential meetings per year, and 48 (67%) took 1 to 3 weeks of vacation annually. Chair salary support includes (from least to most) faculty tax, grants, endowment, school, and hospital. Compensation correlates with age, additional degree, specialty, location, contract, and tenure but not clinical hours. Reported compensation was consistent with data from the Association of American Medical Colleges, but 24 (33%) felt undercompensated. Incentives for job performance were given for clinical productivity (34 chairmen [47%]), department performance (50 [70%]), institutional performance (27 [38%]), and personal accomplishment (14 [19%]). Of 72 chairmen, 30 (42%) were concerned about personal liability related to the job, 15 (21%) had purchased personal liability insurance, and 20 (28%) have defended a lawsuit related to nonclinical responsibilities. Academic surgery department chairmen have a wide array of responsibilities that

  6. An Examination of the Instructional Leadership Role of High School Vice Principals

    Science.gov (United States)

    Larkin, Cynthia

    2017-01-01

    High school vice principals do not typically play a key role in the instructional leadership duties at their sites, as they are typically responsible for being their school's chief disciplinarians, managers of attendance, and supervisors of student activities and athletics. This study examined the role and responsibilities of high school vice…

  7. Time scales: from Nabla calculus to Delta calculus and vice versa via duality

    OpenAIRE

    Caputo, M. Cristina

    2009-01-01

    In this note we show how one can obtain results from the nabla calculus from results on the delta calculus and vice versa via a duality argument. We provide applications of the main results to the calculus of variations on time scales.

  8. The Academic Role of the Vice President for Health Sciences: Can a Walrus Become a Unicorn?

    Science.gov (United States)

    Pellegrino, Edmund D.

    1975-01-01

    The Vice President for Health Sciences is a term used for the chief administrative officer of a multi-unit health science component of a university. This essay reviews this job, and the transformation it has undergone in the past. (Editor/PG)

  9. Manson Chicks and Microskirted Cuties : Pornification in Thomas Pynchon's Inherent Vice

    NARCIS (Netherlands)

    Cook, S.J.|info:eu-repo/dai/nl/411939432

    2015-01-01

    Many sexual encounters in Thomas Pynchon’s fiction have occurred beyond the mainstream, generating theatres of perversity which dramatise the death wish and enact power relations from wider arenas. However, in Inherent Vice they change in nature. With the exception of scenes which use Charles Manson

  10. Effects of Vice-Principals' Psychological Empowerment on Job Satisfaction and Burnout

    Science.gov (United States)

    Schermuly, Carsten C.; Schermuly, Rene A.; Meyer, Bertolt

    2011-01-01

    Purpose: This paper aims to investigate the relationship between psychological empowerment, job satisfaction, and burnout among vice-principals (VPs) in primary schools. Design/methodology/approach: A total of 103 VPs at 103 different primary schools in Germany were surveyed with a questionnaire that assessed the four dimensions of psychological…

  11. 2016-2017 Travel Expense Report for Stephen McGurk, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Beata Bialic

    Purpose: Attend Canada-Israel Official Committee dinner. Date(s):. 2016-06-21. Destination(s):. Toronto. Airfare: $232.04. Other. Transportation: $118.84. Accommodation: $0.00. Meals and. Incidentals: $0.00. Other: $0.00. Total: $350.88. Comments: 2016-2017 Travel Expense Report for Stephen. McGurk, Vice-President ...

  12. 2016-2017 Travel Expense Reports for Stephen McGurk, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Chantal Taylor

    Date(s):. 2017-02-10. Destination(s):. Toronto. Airfare: $765.29. Other. Transportation: $82.91. Accommodation: $0.00. Meals and. Incidentals: $61.60. Other: $0.00. Total: $909.80. Comments: 2016-2017 Travel Expense Reports for. Stephen McGurk, Vice-President, Programs and Partnership Branch.

  13. Dr Jung Hyun KIM Vice Minister for Education, Science and Technology MEST Republic of Korea

    CERN Multimedia

    Jean-Claude Gadmer

    2010-01-01

    He learnt about CERN's LHC computing grid project from Frédéric Hemmer, head of the information technology department. In addition, the vice-minister toured the ATLAS visitor centre, the CMS control centre, the ALICE experiment's exhibition and control room, and he met Korean scientists at CERN.

  14. A Vice-President from the Business World Brings a New Bottom Line to Penn.

    Science.gov (United States)

    van der Werf, Martin

    1999-01-01

    The executive vice-president of the University of Pennsylvania is credited with making significant changes in both the administration and the campus, using cost-cutting and change strategies from his business experience. Outsourcing, training for employees who might be terminated, substantial savings and new revenue, and gentrification of…

  15. Strengthening the University Executive: The Expanding Roles and Remit of Deputy and Pro-Vice-Chancellors

    Science.gov (United States)

    Shepherd, Sue

    2018-01-01

    Deputy and pro-vice-chancellors (DVCs and PVCs) are core members of the executive team and play a pivotal role in university management. Nevertheless, they have rarely been the subject of empirical investigation. This study addresses this research gap, utilising a census to examine the size and remit of the DVC and PVC cohort in English pre-1992…

  16. 2016-2017 Hospitality Expense Report for Stephen McGurk, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Chantal Taylor

    Description: Dinner to discuss IDRC's programming with foreign official. Date: 2017-03-21. Attendees: 3 (IDRC 1). Location: Ottawa. Total: $66.29. Comments: 2016-2017 Hospitality Expense Report for. Stephen McGurk, Vice-President, Programs and Partnership Branch.

  17. A Qualitative Analysis of the Leadership Style of a Vice-Chancellor in a Private University in Malaysia

    Directory of Open Access Journals (Sweden)

    Mabel Tan

    2015-03-01

    Full Text Available This study used Bolman and Deal’s framework to examine the leadership frames of a vice-chancellor in a private university in Malaysia. Qualitative methods comprised interviews with the vice-chancellor and six of his staff reporting directly to him, document analysis, and observations. Atlas.ti was used to code the leadership frames. Content analysis revealed that the vice-chancellor exhibited three frames, showing a multi-frame leadership style. It reflects the vice-chancellor implements an effective leadership style and a high level of cognitive ability, which is important for the organizational effectiveness.

  18. Notes for remarks by William A. Farlinger, chairman of Ontario Hydro

    International Nuclear Information System (INIS)

    Farlinger, W.A.

    1997-01-01

    The advantages of convergence for gas and electric companies were discussed. Both utilities possess transmission lines, rights of way, billing systems and long-term customer relationships. The speaker, Chairman of Ontario Hydro, suggested that within a few years, customers may be in a position to choose their power supplier. Ontario Hydro's vision for convergence and the recent restructuring of the Corporation into three new signature companies (generation, transmission, retail) were described. In this process Ontario Hydro has taken steps toward open access to the grid by all producers, competition among many sellers and buyers, and choice of supplier by consumers for lower cost power. One of the basic driving forces for convergence in the energy field is the interchangeability of electricity or gas. Some municipalities have already implemented joint gas and electricity meter reading, and there are many other ways in which converge can provide cheaper power and better service to the consumer. Ultimately, convergence would mean that monopolies would disappear, as would the boundaries between the gas and electricity industries

  19. Vehicle Infrastructure Cash-Flow Estimation--VICE 2.0; Clean Cities, Energy Efficiency & Renewable Energy (EERE)

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, G.

    2015-04-02

    This presentation discusses the differences between the original Vehicle and Infrastructure Cash-Flow Evaluation (VICE) Model and the revamped version, VICE 2.0. The enhanced tool can now help assess projects to acquire vehicles and infrastructure, or to acquire vehicles only.

  20. EXPRESS

    International Nuclear Information System (INIS)

    Ancelin, C.; Le, P.; DeSaint-Quentin, S.; Villatte, N.

    1987-01-01

    This paper presents EXPRESS, an expert system developed for the automation of reliability studies. The first part consists in the description of the method for static thermohydraulic systems. In this step, the authors define the knowledge representation based on the two inference engines - ALOUETTE and LCR developed by EDF. They explain all the process to construct a fault tree from a topological and functional description of the system. Numerous examples are exhibited in illustration of the method. This is followed by the lessons derived from the studies performed on some safety systems of the PALUEL nuclear plant. The development of the same approach for electric power systems is described, insisting on the difference resulting from the sequential nature of these systems. Finally, they show the main advantages identified during the studies

  1. Tariff Reduction Effects of WTO/DDA Agricultural Negotiations: Analysis of the Chairman's Second Draft Text

    Directory of Open Access Journals (Sweden)

    Se-Kyun Choi

    2003-06-01

    Full Text Available The average tariff reduction rate is 20% point higher in five developed countries analyzed in this study compared to five developing countries following the direction offered by the Chairman's Draft Text. Average tariff reduction rates are 31.6% for the five developing countries and 51.4% for the five developed countries. Korea's tariff reduction rate reaches to 36.1%, the highest reduction in developing countries, when Korea retains the developing country status. When Korea makes tariff reductions following the direction for developed countries, the average tariff reduction rate rises to 55.8%. Tariff reductions following the second Draft Text affect the tariff structure. Tariff escalation, dispersion and peaks can be mitigated by applying the tariff reduction methods proposed in the Second Draft Text. Tariff reductions give rise to the effects of reducing tariff escalation problem and the effects are stronger for the commodities with higher tariff rates and in developed countries. The average tariff rate for tariff peak commodities is reduced by 40% in developing countries and by 60% in developed countries. Tariff dispersion is also mitigated by reducing tariff rates. The difference of the average tariff rate between Korea and Australia is reduced to 38.5% from 59.8% by cutting tariff rates with the rules proposed in the second Draft Text. Korea needs to prepare the Country Schedule in advance to evaluate the potential outcome of the tariff cut following the Draft Text and to capture various voices from producers, consumers and other related institutions. For the preparation of the Country Schedule, Korea needs to decide minimum tariff cut items within a group of the commodity classified by tariff rates and this procedure requires discussion among producer and consumer groups.

  2. Virtues, Vices, and Political Influence in the U.S. Senate.

    Science.gov (United States)

    ten Brinke, Leanne; Liu, Christopher C; Keltner, Dacher; Srivastava, Sameer B

    2016-01-01

    What qualities make a political leader more influential or less influential? Philosophers, political scientists, and psychologists have puzzled over this question, positing two opposing routes to political power--one driven by human virtues, such as courage and wisdom, and the other driven by vices, such as Machiavellianism and psychopathy. By coding nonverbal behaviors displayed in political speeches, we assessed the virtues and vices of 151 U.S. senators. We found that virtuous senators became more influential after they assumed leadership roles, whereas senators who displayed behaviors consistent with vices--particularly psychopathy--became no more influential or even less influential after they assumed leadership roles. Our results inform a long-standing debate about the role of morality and ethics in leadership and have important implications for electing effective government officials. Citizens would be wise to consider a candidate's virtue in casting their votes, which might increase the likelihood that elected officials will have genuine concern for their constituents and simultaneously promote cooperation and progress in government. © The Author(s) 2015.

  3. Virus-Induced Chaperone-Enriched (VICE domains function as nuclear protein quality control centers during HSV-1 infection.

    Directory of Open Access Journals (Sweden)

    Christine M Livingston

    2009-10-01

    Full Text Available Virus-Induced Chaperone-Enriched (VICE domains form adjacent to nuclear viral replication compartments (RC during the early stages of HSV-1 infection. Between 2 and 3 hours post infection at a MOI of 10, host protein quality control machinery such as molecular chaperones (e.g. Hsc70, the 20S proteasome and ubiquitin are reorganized from a diffuse nuclear distribution pattern to sequestration in VICE domains. The observation that VICE domains contain putative misfolded proteins suggests that they may be similar to nuclear inclusion bodies that form under conditions in which the protein quality control machinery is overwhelmed by the presence of misfolded proteins. The detection of Hsc70 in VICE domains, but not in nuclear inclusion bodies, indicates that Hsc70 is specifically reorganized by HSV-1 infection. We hypothesize that HSV-1 infection induces the formation of nuclear protein quality control centers to remodel or degrade aberrant nuclear proteins that would otherwise interfere with productive infection. Detection of proteolytic activity in VICE domains suggests that substrates may be degraded by the 20S proteasome in VICE domains. FRAP analysis reveals that GFP-Hsc70 is dynamically associated with VICE domains, suggesting a role for Hsc70 in scanning the infected nucleus for misfolded proteins. During 42 degrees C heat shock, Hsc70 is redistributed from VICE domains into RC perhaps to remodel viral replication and regulatory proteins that have become insoluble in these compartments. The experiments presented in this paper suggest that VICE domains are nuclear protein quality control centers that are modified by HSV-1 to promote productive infection.

  4. La f trait fibrillation tement da n atriale, ans un serv fréquence vice ...

    African Journals Online (AJOL)

    raoul

    gine de la fib es étaient plu âge > 50 ans e 16, 2010 fréquence vice de ca aba Souley ane Adama acie et Odo. Grand Yoff, D té de Médecin. Hôpital Généra on atriale es travail étaie la fibrillation t d'une étude atients hospit ale était de 5 nce feminine brillation était us fréquentes. (p=0,01) et e, facteur rdiologie ymane1, Bod.

  5. Sugar in disguise or healthy indulgence: A cross-cultural comparision of the perceptions of dietary vice/virtue bundles

    Directory of Open Access Journals (Sweden)

    Jiraporn Napatsorn

    2016-07-01

    Full Text Available Consumers often choose virtue food to attain health goals and vice food to achieve indulgence goals. However, food and beverage companies have begun to nullify the vice and virtue categories by bundling vice and virtue ingredients into a single item (e.g. Yogurt with Oreo topping. This research contrasts how consumers from Asian and Western cultures evaluate such vice/virtue food bundles. Building on the perceptual processes and regulatory focus literatures, two cross-cultural experiments using participants in Thailand and the U.S. shows that Westerners prefer virtue-heavy bundles to vice-heavy bundles while Asians show similar preference across both types of bundle. Process measures revealed that Asians perceive greater fit between vice and virtue components in the bundles than Westerners and this perceived fit mediates the effect of culture on their food choice. Study 2 reveals the boundary condition. Specifically, when regulatory focus was manipulated, the effect of culture is no longer significant. The findings provide managerial implications for food and beverage companies as well as contributions to consumer behavior literature.

  6. Impact of Vice President Cheney on public interest in left ventricular assist devices and heart transplantation.

    Science.gov (United States)

    Pandey, Ambarish; Abdullah, Kazeen; Drazner, Mark H

    2014-05-01

    Although celebrity illnesses attract a significant amount of media attention in the United States, there are few studies that have looked at how celebrity health conditions impact the awareness of the illness in the general population. Recently, Vice President Cheney underwent left ventricular assist device (LVAD) implantation and subsequently a cardiac transplant. The aim of this study was to determine whether there was evidence of increased interest in these 2 procedures as assessed by social media. We determined the relative frequency of Google searches for LVAD and heart transplantation from 2004 to 2013 using Google trends. We also counted the number of YouTube videos and Twitter messages posted monthly concerning LVADs over a 7-year time frame. There was a significant spike in the Google search interest for LVAD and heart transplantation in the month when Vice President Cheney underwent the respective procedure. Similarly, there was a large increase in YouTube videos and Twitter messages concerning LVADs shortly after he was implanted. In total, these data support the concept that a public figure's illness can significantly influence the public's interest in that condition and its associated therapies. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Coexistence of Wormian Bones With Metopism, and Vice Versa, in Adult Skulls.

    Science.gov (United States)

    Cirpan, Sibel; Aksu, Funda; Mas, Nuket; Magden, Abdurrahman Orhan

    2016-03-01

    The aim of the study is to investigate coexistence of Wormian bones with metopism, and vice versa, in adult skulls. A total of 160 dry adult human skulls of unknown sex and ages were randomly selected from the Gross Anatomy Laboratory of Medical School of Dokuz Eylul University. The skulls were examined for presence of metopism, Wormian bones (WB), and coexistence of WBs with metopism and vice versa. Topographic distribution of the WBs was macroscopically evaluated within the skulls including metopism. The photographs were being taken with Canon 400B (55 mm objective). The frequency of metopism and WBs in 160 skulls is 7.50% (12/160) and 59.3% (95/160), respectively, P coexistence of WBs with metopism was found as 11 of 12 skulls (91.66%), whereas the incidence of coexistence of metopism with WBs was found as 11 of 95 skulls (11.58%), P coexistence of WBs with metopism (11/12, 91.66%) and coexistence of metopism with WBs (11/95, 11.58%). The factors leading to metopism may also lead to WBs, whereas that the factors leading to WBs may not lead to metopism.

  8. The academic role of the vice president for health sciences: can a walrus become a unicorn?

    Science.gov (United States)

    Pellegrino, E D

    1975-03-01

    The post of vice president for the health sciences was first developed in an attempt to interpret, modulate, and buffer the growing power of the medical school in the university and the different values that have existed there. The job has been greatly transformed over the past 10 years as a consequence of a variety of factors. Now a genuine creative effort applied to the design of the administration of health sciences centers and how they fit into universities is needed. The present modes of organization are not equal to the challenges that must be faced. New designs must be created which will recognize the special place of the health sciences in today's world and yet keep its function within the university frame.

  9. Utopia and Debt in Postmodernity; or, Time Management in Inherent Vice

    Directory of Open Access Journals (Sweden)

    James Liner

    2016-05-01

    Full Text Available The category of postmodernism has come under renewed scrutiny in recent years. Indeed, it has become rather commonplace to pronounce the death or obsolescence of postmodernism today. Unsurprisingly, the increasingly questioned status of postmodernism also impacts the field of Pynchon studies. This article reads 'Inherent Vice' as symptomatic not of the end but of a transformation of postmodernism and postmodernity. Pynchon’s novel simultaneously registers a contemporary intensification of postmodern/late capitalism and, crucially, participates in a minor current in postmodernism, one which insists on collective agency and utopian thinking despite the atomization and isolation of subjects accomplished by late capitalism and which, against all odds, remembers how to think historically—or better, invents new ways of thinking historically.

  10. Le cru, le cuit et le pourri dans _Le vice-consul_ de Marguerite Duras

    Directory of Open Access Journals (Sweden)

    Hélène Caron

    2011-05-01

    Full Text Available Bien que plusieurs articles critiques aient déjà avancé de nouvelles perspectives sur le texte Le Vice-Consul (LVC de Marguerite Duras, l’analyse de la représentation de la nourriture dans ce roman n’a fait l’objet d’aucune étude. Cet article tente donc de combler cette lacune en proposant d’analyser les images du cru et du cuit, images qui se rejoignent sous les notions du pourri et de l’abject, tout en offrant quelques interprétations de l’un des passages critiques du roman où la folle mendiante croque la tête d’un poisson vivant.

  11. From geometry to algebra and vice versa: Realistic mathematics education principles for analyzing geometry tasks

    Science.gov (United States)

    Jupri, Al

    2017-04-01

    In this article we address how Realistic Mathematics Education (RME) principles, including the intertwinement and the reality principles, are used to analyze geometry tasks. To do so, we carried out three phases of a small-scale study. First we analyzed four geometry problems - considered as tasks inviting the use of problem solving and reasoning skills - theoretically in the light of the RME principles. Second, we tested two problems to 31 undergraduate students of mathematics education program and other two problems to 16 master students of primary mathematics education program. Finally, we analyzed student written work and compared these empirical to the theoretical results. We found that there are discrepancies between what we expected theoretically and what occurred empirically in terms of mathematization and of intertwinement of mathematical concepts from geometry to algebra and vice versa. We conclude that the RME principles provide a fruitful framework for analyzing geometry tasks that, for instance, are intended for assessing student problem solving and reasoning skills.

  12. Career development resource: educational leadership in a department of surgery: vice chairs for education.

    Science.gov (United States)

    Sanfey, Hilary; Boehler, Margaret; DaRosa, Debra; Dunnington, Gary L

    2012-07-01

    The growing appreciation of the need to adopt an evidence-based approach to teaching and assessment has led to a demand for faculty who are well versed in best practices in education. Surgeons with interest and expertise in instruction, curriculum development, educational research, and evaluation can have an important impact on the educational mission of a department of surgery. The increased fervor for accountability in education together with the challenges imposed by accreditation agencies and hospitals has made educational leadership responsibilities more time consuming and complex. In response to this, an increasing number of department chairs created Vice Chair for Education positions to support clerkship and program directors and ensure the department's education mission statement is fulfilled. Copyright © 2012 Elsevier Inc. All rights reserved.

  13. Speech at the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instruction on Western Medicine Doctors Learning Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhu

    2009-01-01

    @@ Respected leaders, distinguished guests, venerable seniors and comrades, Today, the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instructions on Western Medicine Doctors Learning Traditional Chinese Medicine was inaugurated by the Chinese Association of Integrative Medicine, and it is also an important occasion to review the past and look forward to the future.

  14. High-Definition Television: Applications for This New Technology. Fact Sheet for the Chairman, Subcommittee on Telecommunications and Finance, Committee on Energy and Commerce, House of Representatives.

    Science.gov (United States)

    General Accounting Office, Washington, DC. Information Management and Technology Div.

    Prepared in response to a request for information from the chairman of the House of Representatives Subcommittee on Telecommunications and Finance, Committee on Energy and Commerce, this report provides information on 14 high-definition television (HDTV) applications spanning national defense, medical research, space exploration, and electronic…

  15. Career development needs of vice chairs for education in departments of surgery.

    Science.gov (United States)

    Sanfey, Hilary; Boehler, Margaret; Darosa, Debra; Dunnington, Gary L

    2012-01-01

    To identify the career development needs Vice Chair for Education in Surgery Departments (VCESDs). In all, 33 VCESDs were invited to complete an online survey to identify the scope of duties, scholarly activity, job satisfaction, and career development needs. A total of 29/33 (88%) VCESDs responded. Time constraints were the most frequent impediment for MDs vs. PhDs (p teacher programs (1 ± 0), and program performance evaluation systems (1.33 ± 0.76) for PhDs. The skills deemed to be of greatest importance were ability to communicate effectively (1.27 ± 0.55), resolve personnel conflicts (1.32 ± 0.57), and introduce change (1.41 ± 0.59). PhDs revealed a greater need to learn strategies for dealing with disruptive faculty (1.0 ± 0 vs 2.15 ± 0.87). This information will inform the future career development of VCESDs and will assist Department Chairs who wish to recruit and retain VCESDs. Copyright © 2012 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  16. The Effect of Role Ambiguity and Role Conflict on Performance of Vice Principals: The Mediating Role of Burnout

    Science.gov (United States)

    Celik, Kazim

    2013-01-01

    Problem Statement: Role ambiguity and role conflict are considered issues that affect performance and lead to burnout. While numerous studies have analyzed role ambiguity or role conflict in relation to burnout or performance, few studies have studied all of these issues together. Since vice principals are expected to carry out a variety of…

  17. The Lived Experiences of Vice Presidents for Student Affairs: A Study Exploring How Social Identity Impacts Leadership Approach

    Science.gov (United States)

    Jones, David E.

    2016-01-01

    This study aimed to both draw awareness and increase understanding of how lived experiences across race, gender and sexual orientation social identities impact the leadership approach of Vice Presidents for Student Affairs. As the student demographic becomes increasingly more diverse on college and university campuses, higher education leaders…

  18. ICAROG: a computer code that converts a WIMSD/4 format library of BCD code to binary and vice versa

    International Nuclear Information System (INIS)

    Caldeira, A.D.

    1991-09-01

    A program called ICAROG, developed for the CYBER 170/750 system, that converts from BCD to binary code and vice versa a nuclear data library in WIMSD/4 program format is presented. ICAROG has also the capability of separating from the library isotopes specified by the user. (author)

  19. [Remy Willemet (1735-1807), naturalist, professor of natural history and chairman of the botanical garden of Nancy].

    Science.gov (United States)

    Labrude, Pierre

    2015-03-01

    Rémy Willemet is above all a local botanist whose first work was selected by the academy of Nancy in 1766. His notoriety began when another work with Jean-François Coste was chosen by the academy of Lyon ten years later. He published then in many papers and was elected in numerous academies and scientific societies. During the Revolution, he was a professor of the Ecole centrale de la Meurthe and of the Société de santé, and he became the chairman of the botanical garden. Willemet wrote some botanical books. Today, what is the memory of his researchs and papers? Fairly few things because he never undertook botanical travels in order to discover and compare pharmaceutical plants. However, Willemetia was the name used to denominate some species and honour his family. His name was also engraved on the wall of some university buidings and it was chosen some years ago to entitle a botanical paper in Lorraine.

  20. Monsieur Jean-Noël Guerini, Senator, Chairman of the Bouches-du-Rhône General Council

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Monsieur Jean-Noël Guerini, Senator and Chairman of the Bouches-du-Rhône General Council visited CERN on 21 March 2003.Photo 01: Handshake between Monsieur Jean-Noël Guerini and CERN Director-General Luciano Maiani at the signing of the CERN VIP Visitors' book. Left to right: Prof. Cecilia Jarlskog, Member State relations; Prof. Claude Détraz, Director for fixed target and future programmes; Prof. Jean-Jacques Aubert, Director, French national institute for nuclear and particle physics (IN2P3), French Delegate to CERN; Prof. Luciano Maiani, CERN Director-General; Monsieur Jean-Noël Guerini; and Prof. Elie Aslanides, Director, centre for particle physics, Marseille (CPPM).Photo 02: Monsieur Jean-Noël Guerini signs the CERN VIP Visitors' book. Left to right: Prof. Cecilia Jarlskog, Member State relations; Prof. Claude Détraz, Director for fixed target and future programmes; Prof. Jean-Jacques Aubert, Director, French national institute for nuclear and particle physics (IN2P3), French Delegate to CERN; Pr...

  1. Hacia una nueva vicepresidencia : reflexiones desde el caso norteamericano = Towards a new vice presidency? Reflections on the nort american case

    Directory of Open Access Journals (Sweden)

    Mario D. Serrafero

    2013-09-01

    presidente. Y el vicepresidente puede esperar, a su vez, proyección hacia el futuro, incluso la sucesión presidencial. Así se ha señalado que constituye un campo de experiencia y preparación para el cargo máximo: hacia finales del siglo XX trece de los cuarenta presidentes norteamericanos sirvieron en la vicepresidencia. En síntesis, en este estudio se brinda un enfoque de análisis de la vicepresidencia y se tratan algunos de los problemas que ha presentado en los países de America Latina. Luego se realiza un análisis de la experiencia norteamericana y de la evolución de la institución en ese país. El análisis del caso norteamericano resulta útil para iniciar un debate sobre la vicepresidencia en la región, para explorar una necesaria agenda de investigación y como una de las alternativas posibles a la hora de su reforma. In the Presidential Regimes of Latin America, the institution of the Vice Presidency has been barely studied, unlike that of the United States. It only received some comments from authors such as Juan Linz, doubting its effectiveness and pointing out some of the issues surrounding its figure, like the criteria for nomination of candidates and conflicts with the Presidents. But Vice Presidency was practically not taken into account in the debate on presidencialism and parlamentarism, despite being the second place of importance in a presidential regime. With democracy back in the region, Vice Presidency has generated numerous political problems, but there virtually isn’t any academic debate on this. Severe tensions and conflicts between the President and Vice President, even Vice Presidents turned into opponent, are some of the problems observed. On the other hand, some Vice Presidents have taken, with varying success, the role of President be it because of the former’s death or because of political crisis that culminated with the resignation of the President. In the United States, historically, there has been a devalued image of Vice

  2. Five question to... Stanislav Reguli, chairman of the board of directors and general director of the GovCo, joint-stock association

    International Nuclear Information System (INIS)

    Stuller, P.

    2006-01-01

    In this paper the interview with the MR. Stanislav Reguli, chairman of the board of directors and general director of the GovCo, joint-stock association is published. The state company GovCo, a.s. was originated on April 1, 2006. Process of severance of property from the Slovenske elektrarne, a.s., personnel management of new company as well as organisation of property management are presented

  3. Framing Analysis In Media Television News MetroTVOne Related Arrest by the Chairman MK Akil Mocktar Commission Case of Corruption

    Directory of Open Access Journals (Sweden)

    Aryadi Aryadi

    2014-07-01

    Full Text Available Aryadi, G331.10.0018.Framing  Analysis In Media Television News Metro TVOne Related Arrest by   the   Chairman   MK  Akil   Mocktar   Commission   Case   of  Corruption   Skripsi   :  Program   S1   of Communication University of Semarang. This research aims to understand how the framing of television-related  news in the arrest of the chairman of the Constitutional Court AkilMocktar by the Commission on cases of corruption. Impressions is catching  news MK chairman  AkilMocktar  on Metro TV and TVOne. Theoretical  foundation,  framing analysis model of Murray Edelman, the theory is used to understand the reality of diverse and irregular into a reality that has meaning, using the categorization, the use of a particular perspective with certain words is also a word that signifies how the facts or reality understood. Qualitative research methods and strategies for framing the analysis, the study was conducted by observing the video sempel news on Metro TV and TVOne selected. Based on the research results, the general conclusion of each media that Metro TV and TVOne has a different way of constructing a bribery case Mocktar chairman MK Akil is in its message. Metro TV tend to highlight cases of bribery Court of facts, Metro TV does not describe the alleged emerging society. While TVOne looks construct audiences with growing allegations in the news

  4. The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences signing the golden book. Greeting by Mr Robert Aymar, CERN Director General and Prof. Samuel Ting from the MIT.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences signing the golden book. Greeting by Mr Robert Aymar, CERN Director General and Prof. Samuel Ting from the MIT.

  5. The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences visiting the AMS Hall of Prevessin with Prof. Samuel Ting from the MIT.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences visiting the AMS Hall of Prevessin with Prof. Samuel Ting from the MIT.

  6. 9 July 2012 - Academy of Sciences Malaysia (ASM), Chairman, Mathematical and Physical Sciences Discipline Group M. Yahaya FASc and his delegation visiting the LHC superconducting magnet test hall with Technology Department G. De Rijk.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    9 July 2012 - Academy of Sciences Malaysia (ASM), Chairman, Mathematical and Physical Sciences Discipline Group M. Yahaya FASc and his delegation visiting the LHC superconducting magnet test hall with Technology Department G. De Rijk.

  7. 14 April 2014 - UK University College London Hospitals and National Health Service Foundation Trust Chairman R. Murley in the ATLAS cavern with CERN Head of Medical Applications S. Myers and Collaboration Spokesperson D. Charlton.

    CERN Multimedia

    Gadmer, Jean-Claude

    2014-01-01

    Mr Richard Murley Chairman Sir Robert Naylor Chief Executive University College London Hospitals (UCLH) – National Health Service (NHS) Foundation Trust United Kingdom of Great Britain and Northern Ireland

  8. Conference RSIS (The role of science in the information society) - Contributions to Economic Development - Building 40 S2 - B01 - Mr. John Dryden, Chairman, Deputy Director, Organisation for Economic Cooperation and Development.

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Conference RSIS (The role of science in the information society) - Contributions to Economic Development - Building 40 S2 - B01 - Mr. John Dryden, Chairman, Deputy Director, Organisation for Economic Cooperation and Development.

  9. 25 September 2012 - Signature of an Agreement between the Islamic Republic of Pakistan, represented by the Pakistan Atomic Energy Commission Chairman A. Parvez and CERN, represented by its Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    25 September 2012 - Signature of an Agreement between the Islamic Republic of Pakistan, represented by the Pakistan Atomic Energy Commission Chairman A. Parvez and CERN, represented by its Director-General R. Heuer.

  10. Music Export from Helsinki to Berlin and vice versa. Case study: Face of God and Ill Kommodity

    OpenAIRE

    Kuhn, Jennifer

    2013-01-01

    This is a product - oriented thesis. The aim is to conclude a guidebook about music export for young bands that are interested in playing a show abroad. The project: Music export from Helsinki to Berlin and vice versa. Case study: Face of God and Ill Kommodity, was used to learn from the praxis. The thesis describes the responsibilities of the project manager and brings project management and event planning together. The music export history of Finland and Germany is taken in considerat...

  11. Measuring The Democratization Degree According To Law Number 42 Of 2008 Concerning General Election Of The President And Vice President

    OpenAIRE

    Putra Wijaya, I Dewa Made

    2014-01-01

    This research aims to study the consistency of the Act No 42 of 2008 concerning the generalelection on president and vice president related to the principles of democracy as stipulated inthe constitution of Indonesian republic of 1945. This research uses statutory and conceptualapproaches. The object of the research is the policy of the general election on president and vicepresident. While the subject of it are the parliament and government as legislator. The legalmaterial of the research co...

  12. RECONSTRUCTION THE AUTHORITY OF CONSTITUTIONAL COURT ON IMPEACHMENT PROCESS OF PRESIDENT AND/OR VICE PRESIDENT IN INDONESIAN CONSTITUTIONAL SYSTEM

    Directory of Open Access Journals (Sweden)

    Hezron Sabar Rotua Tinambunan

    2016-06-01

    Full Text Available In the process of impeachment, Constitutional Court has the obligation to give its judgement to House of Representatives’s opinion regarding allegation of violation by the President and/or Vice President. Constitutional Court checks and judges House of Representatives’s opinion on whether or not the President and/or Vice President works fulfill Article 7A of Constitution of Republic Indonesia 1945 (UUD NRI 1945. The inspection done by Constitutional Court is the judicial process whose decision is in the form of justisil. The result of this impeachment process heavily depends on the judgement of People's Consultative Assembly in its plenary meeting which is also a politics forum, where President and/or Vice President could be dismissed or not. Constitutional Court’s judgement does not apply to People's Consultative Assembly, hence, the difference of Constitutional Court and People's Consultative Assembly’s judgement in plenary meeting that is very political by its nature is very likely to happen. Involvement of Constitutional Court in the procss of impeachment is, of course, different in each country. It depends on governance system in that particular country, it also relies on how much authority that is given by Constitution to Constitutional Court in the process of impeachment itself.

  13. 31 March 2016 - Qatar Foundation Research and Development Executive Vice President H. Al-Ibrahim signing a Cooperation Agreement with CERN Director-General F. Gianotti.

    CERN Multimedia

    Brice, Maximilien

    2016-01-01

    Dr Hamad Al-Ibrahim Executive Vice President, Qatar Foundation Research and Development. Were present: CERN International Relations Unit, Adviser for Qatar P. Fassnacht; CERN Director for Research and Computing E. Elsen; Texas A&M Professor of Physics A. Safonov ; CERN Director for International Relations C. Warakaulle; Professor of Physics, Qatar University I.Al-Qaradawi; Executive Vice President H. Al-Ibrahim; CERN Director-General F. Gianotti; Ambassador Faisal Bin Abdulla Al-Henzab to the UNOG; Director of Research Computing, Texas A&M, Qatar O. Bouhali; Vice Dean, Texas A&M, Qatar E. Massad; Executive Director, Research Coordination & Special Initiatives, Qatar Foundation R&D D. Khoury.

  14. Comments by the Chairman

    Science.gov (United States)

    Fouillat, Pascal

    2013-08-01

    The European Conference on Radiation and its Effects on Components and Systems (RADECS 2012) was held on September 24-28, 2012, in Biarritz, France. The latest advances in the field of radiation effects on electronic and photonic materials, devices, circuits, sensors, and systems, were presented and discussed. The conference featured a Technical Program, an Industrial Exhibit, and one day meeting on radiation ground effects held on September 24 (RADGROUND). The conference gathered 390 attendees, scientists and engineers from 26 countries, with a high participation of France (101), USA (80), Russia (50), Spain (28), Germany (28), and U.K. (25). Raoul Velazco, from TIMA Labs, was in charge of the Technical Program, assisted by a Technical Program Committee listed below and a pool ofmore than 150 reviewers which contributed maintain the high level of quality reached since many years by the RADECS conferences. The total number of contributions reached 201 and each paper received at least four reviews. There were 145 papers accepted and presented in the Oral Sessions (48), Poster Sessions (69), and Data Workshop (28). The scope of the conference encompassed technological processes and design techniques for producing radiation tolerant systems for space, aeronautical or terrestrial applications, as well as relevant methodologies for their characterization and qualification. The Conference Record, gathering all the papers compliant with IEEE quality standards and editorial rules, is available through the IEEE Xplore Digital Library. The paper candidates and selected for publication in the IEEE TRANSACTIONS ON NUCLEAR SCIENCE will be published in this special issue.

  15. The vices of emperor Constans I in the fourth century histories

    Directory of Open Access Journals (Sweden)

    Milivojević Uroš

    2008-01-01

    Full Text Available The aim of this paper is to analyze the negative characteristics of the Roman emperor Constans I (337-350, according to the earliest preserved information from the late 4th century histories of Aurelius Victor, Eutropius Pseudo-Victor and Eunapius of Sardis. The earliest account of Constans' downfall is around 361 recorded by Aurelius Victor in his short history De Caesaribus. Victor wrote that Constans became more arrogant and aggressive after he defeated his elder brother Constantine II in 340. Also, he was not cautious enough for his young age, was hated due to his bad subordinates and did not respect his soldiers properly. But, the most outrageous fact was according to Victor, that the emperor had homosexual affinity towards his young and attractive barbarian hostages. The record of less moralistic Eutropius in his Breviarium ab Urbe condita, written in 369, is shorter but sharper. In the beginning the reign of Constans was vigorous and righteous but his character deteriorated after his illness. Following that, the young Augustus befriended himself with corrupted companions and turned to severe vices. His reign grew unbearable to his subjects and unpopular among the army ranks. Briefer then Eutropis is the testimony of an anonymous Latin author of Epitome de caesaribus who was contemporary to the Eastern Roman emperor Arcadius (395-408. This Pseudo-Victor wrote down that Constans devoted himself to hunting session, thus allowing plotters to dethrone him. Finally the single Greek author in this series, Eunapius (died after 404, whose istoria h meta Dexippon survived in fragments and Zosimus' late fifth century abridgment, called Constans the worst among the most intolerable tyrants. The Lydian sophist, as far as we could conclude from Zosimus', also recorded Constans' inclination towards young barbarians whom he allowed to mistreat his subjects. Because of wretchedness in the provinces of his realm, the courtiers led coup d'etat through

  16. Vices, gods, and virtues: cosmology as a mediating factor in attitudes toward male homosexuality.

    Science.gov (United States)

    Hoffman, R J

    Using historical and anthropological evidence, the article examines the relationship of the polytheistic and monotheistic cosmologies and attitudes toward sexuality, in particular, male homosexuality. The polytheistic cosmology included the ideas of the continuity of creation, the generative forces of the universe as a whole, and gender blurring in the realm of the supernatural. In the monotheistic cosmology the godhead (Yahweh) is unborn and does not father any generations, the universe is desexualized, and the conception of gender is rigidified. The author concludes that polytheism created the conditions for a wide variety of sexual expression and sex-role behavior and did not preclude any particular form of sexual activity. In contradistinction, the monotheistic cosmology was highly restrictive of permissible male and female behavior and sexual expression and conduct. Consequently, polytheism was able to embrace the crossing of gender lines and homosexual relationships while monotheism was incapable of making these accommodations.

  17. Evaluating Investments in Natural Gas Vehicles and Infrastructure for Your Fleet: Vehicle Infrastructure Cash-Flow Estimation -- VICE 2.0; Clean Cities, Energy Efficiency & Renewable Energy (EERE)

    Energy Technology Data Exchange (ETDEWEB)

    Gonzales, John

    2015-04-02

    Presentation by Senior Engineer John Gonzales on Evaluating Investments in Natural Gas Vehicles and Infrastructure for Your Fleet using the Vehicle Infrastructure Cash-flow Estimation (VICE) 2.0 model.

  18. White House Office of the Vice President Announces New Memorandum of Understanding in Clinical Proteogenomics Between the United States and Australia | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The White House Office of the Vice President has announced the signing of three Memoranda of Understanding (MOUs) that will make available an unprecedented international dataset to advance cancer research and care.

  19. 24 February 2012 - Polish Vice-Rectors AGH University of Science and Technology Cracow visiting the ATLAS underground experimental area with Former Collaboration Spokesperson P. Jenni; Vice Rector J. Lis signs a collaboration agreement with A. Unnervik; Adviser T. Kurtyka and A. Siemko accompany the delegation throughout.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    24 February 2012 - Polish Vice-Rectors AGH University of Science and Technology Cracow visiting the ATLAS underground experimental area with Former Collaboration Spokesperson P. Jenni; Vice Rector J. Lis signs a collaboration agreement with A. Unnervik; Adviser T. Kurtyka and A. Siemko accompany the delegation throughout.

  20. Auditory Emotion Word Primes Influence Emotional Face Categorization in Children and Adults, but Not Vice Versa.

    Science.gov (United States)

    Vesker, Michael; Bahn, Daniela; Kauschke, Christina; Tschense, Monika; Degé, Franziska; Schwarzer, Gudrun

    2018-01-01

    In order to assess how the perception of audible speech and facial expressions influence one another for the perception of emotions, and how this influence might change over the course of development, we conducted two cross-modal priming experiments with three age groups of children (6-, 9-, and 12-years old), as well as college-aged adults. In Experiment 1, 74 children and 24 adult participants were tasked with categorizing photographs of emotional faces as positive or negative as quickly as possible after being primed with emotion words presented via audio in valence-congruent and valence-incongruent trials. In Experiment 2, 67 children and 24 adult participants carried out a similar categorization task, but with faces acting as visual primes, and emotion words acting as auditory targets. The results of Experiment 1 showed that participants made more errors when categorizing positive faces primed by negative words versus positive words, and that 6-year-old children are particularly sensitive to positive word primes, giving faster correct responses regardless of target valence. Meanwhile, the results of Experiment 2 did not show any congruency effects for priming by facial expressions. Thus, audible emotion words seem to exert an influence on the emotional categorization of faces, while faces do not seem to influence the categorization of emotion words in a significant way.

  1. Combining food type(s) and food quantity choice in a new food choice paradigm based on vice-virtue bundles.

    Science.gov (United States)

    Haws, Kelly L; Liu, Peggy J

    2016-08-01

    Given the prevalence and rising rates of obesity in many countries, including the United States, much food decision-making research ultimately aims at understanding how consumers can make healthier choices. The two predominant choice paradigms used in food decision-making research ask consumers to choose (a) between a "vice" (or unhealthy food) and a "virtue" (or healthy food) or (b) among varying portion sizes of "vice." We propose a new food choice paradigm that encourages consumers to jointly consider both food type(s) choice and food portion size at each decision point. The purpose of this paradigm is two-fold. First, it aims to allow examination of more comprehensive eating behavior (e.g., to examine the overall composition of a plate of food rather than choice of a single food). Second, it aims to shift consumers towards including large proportions of virtues and smaller proportions of vice in their overall consumption portfolios. For this paradigm, we draw upon a recently introduced food product innovation called "vice-virtue bundles" (Liu et al., 2015) that illustrates the basis of this new food choice paradigm, in which food type(s) and portion decisions are made simultaneously. Accordingly, we first discuss relevant findings on vice-virtue bundles as well as the differences between simultaneous and sequential choice of multiple products. Second, we examine the benefits for managing and controlling one's consumption that are provided by vice-virtue bundles and this joint food choice paradigm more generally. Third and finally, we point out opportunities for future research by discussing (a) multiple factors that influence food choices, (b) decision processes affected by food choice paradigms, and (c) issues of generalizability related to the presence of vice-virtue bundles. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. All order running coupling BFKL evolution from GLAP (and vice versa)

    International Nuclear Information System (INIS)

    Ball, Richard D.; Forte, Stefano

    2006-01-01

    We present a systematic formalism for the derivation of the kernel of the BFKL equation from that of the GLAP equation and conversely to any given order, with full inclusion of the running of the coupling. The running coupling is treated as an operator, reducing the inclusion of running coupling effects and their factorization to a purely algebraic problem. We show how the GLAP anomalous dimensions which resum large logs of 1x can be derived from the running-coupling BFKL kernel order by order, thereby obtaining a constructive all-order proof of small x factorization. We check this result by explicitly calculating the running coupling contributions to GLAP anomalous dimensions up to next-to-next-to leading order. We finally derive an explicit expression for BFKL kernels which resum large logs of Q 2 up to next-to-leading order from the corresponding GLAP kernels, thus making possible a consistent collinear improvement of the BFKL equation up to the same order

  3. The Proud Prime Evil of Hell: Characterization of Satan as the Capital Vice of Pride in Milton’s Paradise Lost

    Directory of Open Access Journals (Sweden)

    David Hazemali

    2016-12-01

    Full Text Available This paper looks into the characterisation of Satan as the Capital Vice of Pride in John Milton’s Paradise Lost. It thus supports the findings of Robert Charles Fox, who in his study The Seven Deadly Sins in Paradise Lost first thoroughly analysed and comprehensively presented this issue and its importance in Milton’s epic. The authors of the study share Fox’s belief that Milton consciously used the system of the Seven Capital Vices in his epic as a structural device to present the entire scope of evil to the willing reader, and he achieved this by giving Satan and six other major denizens of Hell each the characteristics of a particular Vice. In other words, each of the seven major diabolical figures that appear in Paradise Lost embodies or personifies one of the Seven Capital Vices. As the most eloquent and characteristically perfected of the diabolical figures of Hell, Satan embodies Pride, the prime Capital Vice.

  4. RTE - 2013 Activity Report, 2013 Activity and Sustainable Development Report, financial results for 2013, Report of the Chairman of the Supervisory Board

    International Nuclear Information System (INIS)

    2014-01-01

    RTE is the operator of the high and extra high-voltage transmission system in France. RTE operates, develops and maintains it. This role places RTE at the heart of smart power, supplying its customers: generators, distribution system operators, industrial customers and traders. RTE deploys its expertise to achieve smart power, with three objectives: - To optimise the power system so that everything operates at the lowest cost, every second, whatever the weather brings, whatever the level of supply and demand. - To guarantee a secure power supply, by offering tools and mechanisms that can be used to adjust generation and power consumption. - To adapt the grid to energy transition through constant innovation. RTE counts 8,400 employees. This document gathers both French and English versions of the 2013 Activity and Sustainable Development Report and the English version of the 2013 financial results and of the Report of the Chairman of the Supervisory Board

  5. From “Goal-Orientated, Strong and Decisive Leader” to “Collaborative and Communicative Listener”. Gendered Shifts in Vice-Chancellor Ideals, 1990–2018

    Directory of Open Access Journals (Sweden)

    Helen Peterson

    2018-06-01

    Full Text Available Applying a critical gendered lens, this article examines academic leadership ideals. It draws on a content analysis of job advertisements for Vice-Chancellors at Swedish higher education institutions from 1990 until 2018. The aim of the article is to investigate to what extent masculine or feminine wordings have been used to describe the ideal Vice-Chancellor in these documents. The analysis reveals that a shift in the leadership ideal has taken place during the time period investigated. Before this shift, during the 1990s, the ideal Vice-Chancellor was described as competitive, bold, strong, tough, decisive, driven, and assertive. These wordings are still included in the job advertisements from the 2000s and the 2010s. However, a more communicative and collaborative leadership ideal also emerges during these decades. There is thus a significant shift in how the leadership ideal is described. This shift is analyzed from a gendered perspective, suggesting that the traditional masculine-biased leadership ideal has decreased in influence with the feminine, transformational leadership ideal acting as a counterweight. The article argues that the shift in leadership ideals, as constructed in the job advertisements, mirrors the increase of women Vice-Chancellors appointed in the Swedish higher education sector.

  6. Visit of the chinese Vice-President of the people's republic of China, Hu Jintao, at the Bugey nuclear power plant

    International Nuclear Information System (INIS)

    2001-11-01

    During the visit of the Vice-President of the people's republic of China at the Bugey nuclear power plant, EDF showed its will of cooperation with China in the energy domain. This document presents the main aspects of this cooperation: the chinese electric power system panorama, the EDF investments in China and the future development. (A.L.B.)

  7. Sequence Exchange between Homologous NB-LRR Genes Converts Virus Resistance into Nematode Resistance, and Vice Versa.

    Science.gov (United States)

    Slootweg, Erik; Koropacka, Kamila; Roosien, Jan; Dees, Robert; Overmars, Hein; Lankhorst, Rene Klein; van Schaik, Casper; Pomp, Rikus; Bouwman, Liesbeth; Helder, Johannes; Schots, Arjen; Bakker, Jaap; Smant, Geert; Goverse, Aska

    2017-09-01

    Plants have evolved a limited repertoire of NB-LRR disease resistance ( R ) genes to protect themselves against myriad pathogens. This limitation is thought to be counterbalanced by the rapid evolution of NB-LRR proteins, as only a few sequence changes have been shown to be sufficient to alter resistance specificities toward novel strains of a pathogen. However, little is known about the flexibility of NB-LRR R genes to switch resistance specificities between phylogenetically unrelated pathogens. To investigate this, we created domain swaps between the close homologs Gpa2 and Rx1 , which confer resistance in potato ( Solanum tuberosum ) to the cyst nematode Globodera pallida and Potato virus X , respectively. The genetic fusion of the CC-NB-ARC of Gpa2 with the LRR of Rx1 (Gpa2 CN /Rx1 L ) results in autoactivity, but lowering the protein levels restored its specific activation response, including extreme resistance to Potato virus X in potato shoots. The reciprocal chimera (Rx1 CN /Gpa2 L ) shows a loss-of-function phenotype, but exchange of the first three LRRs of Gpa2 by the corresponding region of Rx1 was sufficient to regain a wild-type resistance response to G. pallida in the roots. These data demonstrate that exchanging the recognition moiety in the LRR is sufficient to convert extreme virus resistance in the leaves into mild nematode resistance in the roots, and vice versa. In addition, we show that the CC-NB-ARC can operate independently of the recognition specificities defined by the LRR domain, either aboveground or belowground. These data show the versatility of NB-LRR genes to generate resistance to unrelated pathogens with completely different lifestyles and routes of invasion. © 2017 American Society of Plant Biologists. All Rights Reserved.

  8. Asian Youth Cultural Expression, Creativity, and Innovation on YouTube

    OpenAIRE

    Zinggara Hidayat

    2017-01-01

    Groups and intercommunity interactions form global society. This study aims to describe the global aspect in the local cultural expression or vice-versa on YouTube videos. The cultural expressions include language, dress, cuisine, festivals and leisure creativities, social customs and lifestyle. Qualitative descriptive approach is used to analyze ten videos made by Southeast Asian young people. This research found that the locality expression goes global. Cultural expressions communicate the ...

  9. Commentary: linking health equity with economic development: insights from my year as Chairman of the Board of the Chamber of Commerce.

    Science.gov (United States)

    Clancy, Gerard P

    2012-12-01

    Many urban areas struggle with significant health disparities. In Tulsa, Oklahoma, there is a 14-year difference in life expectancy between the predominantly African American population in north Tulsa and the predominantly Caucasian population in south Tulsa. The roots of Tulsa's health disparities can be linked, in part, to a long history of racial mistrust stemming from the 1921 Tulsa Race Riot, arguably one of the worst race riots in U.S. history. In 2011, the author served as both a university campus president and chairman of the board of the Tulsa region's chamber of commerce. Through his work with the chamber, he discovered the business community's substantial resources and advocacy abilities. He also found that regional business leaders strongly supported health equity, diversity, and inclusion initiatives, both as moral obligations and regional economic development imperatives. After sharing the lessons he learned from working closely with business leaders, the author encourages other academic health centers (AHCs) to reach out to their business communities, which are likely willing and able to help them undertake similar initiatives. In doing so, AHCs and businesses can work together to improve the economic vitality of their regions.

  10. Video Release: 47th Vice President of the United States Joseph R. Biden Jr. Speech at HUPO2017 Global Leadership Gala | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The Human Proteome Organization (HUPO) has released a video of the keynote speech given by the 47th Vice President of the United States of America Joseph R. Biden Jr. at the HUPO2017 Global Leadership Gala. Under the gala theme “International Cooperation in the Fight Against Cancer,” Biden recognized cancer as a collection of related diseases, the importance of data sharing and harmonization, and the need for collaboration across scientific disciplines as inflection points in cancer research.

  11. Opium: The Evolution of Policies, the Tolerance of the Vice, and the Proliferation of Contraband Trade in the Philippines, 1843-1908

    OpenAIRE

    Alma N. Bamero

    2006-01-01

    This research entitled “Opium: The Evolution of Policies, the Tolerance of the Vice, and the Proliferation of Contraband Trade in the Philippines, 1843-1908” presents a discussion of the opium trade in Asia, the commercial networks it created, the political ties it strengthened, and the social relations itfostered. It also aims to reconstruct an aspect of Philippine social history in the nineteenth century through the use of archival materials that bear witness to the distribution and exploit...

  12. At the United Nation Foundation's Social Good Summit, Vice President Biden Announces New Cancer Moonshot International Cooperation and Investments | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    This week, Vice President Joe Biden announced progress on his global vision for the Cancer Moonshot.  Announced were 10 new Memoranda of Understanding or Memoranda of Cooperation for international cancer research and care, as well as new efforts in the emerging scientific areas of precision oncology, the funding of collaborative research centers to address cancer disparities in low- and middle- income (LMIC) countries, and a strengthening of existing U.S. bilateral science and technology engagements around cancer.  

  13. Face Processing in Children with Autism Spectrum Disorder: Independent or Interactive Processing of Facial Identity and Facial Expression?

    Science.gov (United States)

    Krebs, Julia F.; Biswas, Ajanta; Pascalis, Olivier; Kamp-Becker, Inge; Remschmidt, Helmuth; Schwarzer, Gudrun

    2011-01-01

    The current study investigated if deficits in processing emotional expression affect facial identity processing and vice versa in children with autism spectrum disorder. Children with autism and IQ and age matched typically developing children classified faces either by emotional expression, thereby ignoring facial identity or by facial identity…

  14. [Alfredo Tramoyeres Cases (1910-2002): first chairman of the Department of Urology at the Ciudad Sanitaria La Fe. Documentary-historical analysis of his works].

    Science.gov (United States)

    Cánovas Ivorra, José Antonio; Tramoyeres Galvañ, Alfredo; Sánchez Ballester, Francisco; De la Torre Abril, Luis; Ordoño Domínguez, Felipe; Navalón Verdejo, Pedro; Pérez Albacete, Mariano; López Alcina, Emilio; Zaragoza Orts, Julio

    2004-12-01

    Urology, having been part of general surgery for centuries, was completely consolidated as a medical speciality in the middle of the XX Century as the result of years of evolution and development, and all the studies and works of certain authors that represent today the mainstays of our speciality. Valencia in the middle of the 20th century saw the birth of new hospitals including the "Ciudad Sanitaria La Fe". Alfredo Tramoyeres Cases was the first chairman of the Department of Urology. This article reviews his long and fertile professional life. We have reviewed all his scientific works. The articles have been obtained from Medicina Española, Revista Española de Cirugía Traumatológica y Ortopedia, and Archivos Españoles de Urología. His most important urological work is his doctoral thesis with the title "Sigmoid-procto-ureterostomy: personal modification" published in Valencia in 1976. For his biography we used the" Biographic and bibliographic history of the Spanish Urology over the XX century" and interviews with family members. We emphasize his thorough description of the various types of urinary diversion. He covers the topics of bladder diverticula and bladder neck disorders, in which he supports surgical treatment. Finally, he sets out the rupture of the posterior urethra and various treatments for prostate cancer at that time. Alfredo Tramoyeres Cases contributed to the definitive consolidation of our speciality in the area of Valencia during the second half of the XX century, through his long professional life, with his interesting scientific contributions.

  15. The Picaresque Writer: What a Reading of Apuleius' Metamorphoses Can Tell about Lazarillo de Tormes (and Vice Versa

    Directory of Open Access Journals (Sweden)

    Zala Rott

    2009-12-01

    All in all, the one obvious thing is the transition from an oral form of expression to a (more elaborate written one: from a speech, fable, or story to a book, letter, or novel, where the real victim is the reader.

  16. Letter from the Friends Chairman

    Science.gov (United States)

    ... additional copies of the publication. That is exactly the kind of response we hoped to receive. We have one goal—to provide you with a gold standard of reliable, understandable and up-to-date health ...

  17. 27 May 2010 - Members of the Scientific and Technological Options Assessment Panel (STOA), European Parliament, visiting the LHC superconducting magnet test hall (SM18) with Technology Deputy Department Head L. Rossi and accompanied by CERN Head of the EU Project Office S. Stavrev and CERN EU Projects for Accelerator Technology and Coordinator of FP7 EuCRAD J.-P. Koutchouk.

    CERN Multimedia

    Jean-Claude Gadmer

    2010-01-01

    CERN-HI-1005086 tirage 16: The delegation was led by STOA Vice Chairman and Member of IMCO Committee A. F. Correia de Campos MEP and STOA Vice Chairman and IMCO Committee Chairman M. Harbour MEP (2nd and 3rd on this photograph).

  18. Visit of Mr. Susumu Yoda, Japanese Atomic Energy Commission, Mr. Nobuo Natsume, Vice-President, Central Research Institute of Electric Power Industry, Japan (CRIEPI), Mr. Nobuya Yoshiki, CRIEPI, Mrs. Seiko Ichikawa, Interpreter, with Mr. Taylor of CERN, visiting SM18

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Visit of Mr. Susumu Yoda, Japanese Atomic Energy Commission, Mr. Nobuo Natsume, Vice-President, Central Research Institute of Electric Power Industry, Japan (CRIEPI), Mr. Nobuya Yoshiki, CRIEPI, Mrs. Seiko Ichikawa, Interpreter, with Mr. Taylor of CERN, visiting SM18

  19. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

  20. UK Institute of Physics (IOP) President Sir Gareth Roberts (right) at CERN on 9 July with (right to left) IOP council vice-president and distinguished physicist Peter Kalmus, CERN engineer Tim Watson and IOP director of science Peter Cooper

    CERN Multimedia

    Patrice Loiez

    1999-01-01

    UK Institute of Physics (IOP) President Sir Gareth Roberts (right) at CERN on 9 July with (right to left) IOP council vice-president and distinguished physicist Peter Kalmus, CERN engineer Tim Watson and IOP director of science Peter Cooper

  1. 28 October 2013- Former US Vice President A. Gore signing the guest book with Technology Department Head F. Bordry, Head of International Relations R. Voss, Director for Research and Scientific Computing S. Bertolucci and CMS Collaboration Spokesperson J. Incandela.

    CERN Multimedia

    Maximilien Brice

    2013-01-01

    28 October 2013- Former US Vice President A. Gore signing the guest book with Technology Department Head F. Bordry, Head of International Relations R. Voss, Director for Research and Scientific Computing S. Bertolucci and CMS Collaboration Spokesperson J. Incandela.

  2. 1st October 2010 - Chinese Vice President of the Academy of Sciences signing the guest book and exchanging gifts with CERN Director for Research and Scientific Computing S. Bertolucci, witnessed by Adviser R. Voss

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    1st October 2010 - Chinese Vice President of the Academy of Sciences signing the guest book and exchanging gifts with CERN Director for Research and Scientific Computing S. Bertolucci, witnessed by Adviser R. Voss

  3. Conference RSIS (The role of science in the information society) - Contributions to Economic Development - Building 40 S2 - B01 - Mr. Mohammad Nahavandian, Vice-President for Research, Institute for Humanities and Cultural Studies, Tehran.

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Conference RSIS (The role of science in the information society) - Contributions to Economic Development - Building 40 S2 - B01 - Mr. Mohammad Nahavandian, Vice-President for Research, Institute for Humanities and Cultural Studies, Tehran.

  4. 29 January 2013 - Japanese Toshiba Corporation Executive Officer and Corporate Senior Vice President O. Maekawa in the ATLAS visitor centre with representatives of the CERN-Japanese community led by Former Collaboration Spokesperson P. Jenni.

    CERN Multimedia

    Maximilien Brice

    2013-01-01

    29 January 2013 - Japanese Toshiba Corporation Executive Officer and Corporate Senior Vice President O. Maekawa in the ATLAS visitor centre with representatives of the CERN-Japanese community led by Former Collaboration Spokesperson P. Jenni.

  5. 14 February 2012 - Vice-President of the Senate of the Parliament of the Czech Republic A. Gajduskova signing the guest book with CERN Director-General R. Heuer; visiting ATLAS experimental area with Collaboration Spokesperson F. Gianotti. Ambassador Sequensova to the UN accompanies the Vice-President.

    CERN Document Server

    Maximilien Brice

    2012-01-01

    Vice-president of the Senate of the Parliament of the Czech Republic, Alena Gajduskova was welcomed to CERN by Rolf Heuer, CERN’s director-general, on 14 and 15 February. Her time at CERN included the ATLAS Visitor Centre and underground experimental area, the LHC tunnel, the LHC superconducting-magnet test hall and the ALICE underground experimental area. She also heard a presentation on the LHC Computing Grid Project at CERN’s Computer Centre.

  6. The Effort to Save Somalia, August 1992-March 1994

    National Research Council Canada - National Science Library

    Poole, Walter S

    2005-01-01

    In shaping policy towards Somalia, the Chairman of the Joint Chiefs of Staff, the Vice Chairman, and the Joint Staff had to advise how US military forces could execute an evolving range of missions "other than war...

  7. 77 FR 28923 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-05-16

    ... Session of the International Maritime Organization's (IMO) Sub-Committee on Safety of Navigation to be... --Election of Chairman and Vice-Chairman for 2013 --Any other business --Report to the Maritime Safety...

  8. 26th February 2009 - US Google Vice President and Chief Internet Evangelist V. Cerf signing the guest book with Director for research and Computing S. Bertolucci; visiting ATLAS control room and experimental area with Collaboration Spokesperson P. Jenni.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    HI-0902038 05: IT Department Head, F. Hemmer; US Google Vice President and Chief Internet Evangelist V. Cerf; Computing Security Officer and Colloquium Convenor D. R. Myers; Member of the Internet Society Advisory Council F. Flückiger; Director for Research and Scientific Computing, S. Bertolucci ; Honorary Staff Member, B. Segal. HI-0902038 16: Computing Security Officer and Colloquium Convenor D. R. Myers; UC Irvine, ATLAS Deputy Spokesperson elect A. J. Lankford; US Google Vice President and Chief Internet Evangelist V. Cerf; ATLAS Collaboration Spokesperson P. Jenni; IT Department Head, F. Hemmer.

  9. Thyrotropin-Blocking Autoantibodies and Thyroid-Stimulating Autoantibodies: Potential Mechanisms Involved in the Pendulum Swinging from Hypothyroidism to Hyperthyroidism or Vice Versa

    Science.gov (United States)

    Rapoport, Basil

    2013-01-01

    Background Thyrotropin receptor (TSHR) antibodies that stimulate the thyroid (TSAb) cause Graves' hyperthyroidism and TSHR antibodies which block thyrotropin action (TBAb) are occasionally responsible for hypothyroidism. Unusual patients switch from TSAb to TBAb (or vice versa) with concomitant thyroid function changes. We have examined case reports to obtain insight into the basis for “switching.” Summary TBAb to TSAb switching occurs in patients treated with levothyroxine (LT4); the reverse switch (TBAb to TSAb) occurs after anti-thyroid drug therapy; TSAb/TBAb alterations may occur during pregnancy and are well recognized in transient neonatal thyroid dysfunction. Factors that may impact the shift include: (i) LT4 treatment, usually associated with decreased thyroid autoantibodies, in unusual patients induces or enhances thyroid autoantibody levels; (ii) antithyroid drug treatment decreases thyroid autoantibody levels; (iii) hyperthyroidism can polarize antigen-presenting cells, leading to impaired development of regulatory T cells, thereby compromising control of autoimmunity; (iv) immune-suppression/hemodilution reduces thyroid autoantibodies during pregnancy and rebounds postpartum; (v) maternally transferred IgG transiently impacts thyroid function in neonates until metabolized; (vi) a Graves' disease model involving immunizing TSHR-knockout mice with mouse TSHR-adenovirus and transfer of TSHR antibody-secreting splenocytes to athymic mice demonstrates the TSAb to TBAb shift, paralleling the outcome of maternally transferred “term limited” TSHR antibodies in neonates. Finally, perhaps most important, as illustrated by dilution analyses of patients' sera in vitro, TSHR antibody concentrations and affinities play a critical role in switching TSAb and TBAb functional activities in vivo. Conclusions Switching between TBAb and TSAb (or vice versa) occurs in unusual patients after LT4 therapy for hypothyroidism or anti-thyroid drug treatment for Graves

  10. Asian Youth Cultural Expression, Creativity, and Innovation on YouTube

    Directory of Open Access Journals (Sweden)

    Zinggara Hidayat

    2017-06-01

    Full Text Available Groups and intercommunity interactions form global society. This study aims to describe the global aspect in the local cultural expression or vice-versa on YouTube videos. The cultural expressions include language, dress, cuisine, festivals and leisure creativities, social customs and lifestyle. Qualitative descriptive approach is used to analyze ten videos made by Southeast Asian young people. This research found that the locality expression goes global. Cultural expressions communicate the cross-cultural understanding especially in mainland, peninsula, and islands. This youth creativity describes the “glocality” of Indian, Arabic, Chinese, Malay, Java, and the West cultures.

  11. 13 September 2013 - Chairman of the Board of Directors of the von Karman Institute Kingdom of Belgium J.-P. Contzen visiting the ATLAS experimental cavern with ATLAS Former Spokesperson P. Jenni; visiting the LHC tunnel at Point 1 with Technology Department N. Delruelle and signing the guest book with Technology Department Head F. Bordry. International Relations Adviser T. Kurtyka present.

    CERN Multimedia

    Laurent Egli (visit)

    2013-01-01

    13 September 2013 - Chairman of the Board of Directors of the von Karman Institute Kingdom of Belgium J.-P. Contzen visiting the ATLAS experimental cavern with ATLAS Former Spokesperson P. Jenni; visiting the LHC tunnel at Point 1 with Technology Department N. Delruelle and signing the guest book with Technology Department Head F. Bordry. International Relations Adviser T. Kurtyka present.

  12. 18 December 2013 - P. Kron Chairman and Chief Executive Officer of ALSTOM signing the Guest Book with the Director-General R. Heuer and visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry. Accompanied by P. Fassnacht throughout.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    18 December 2013 - P. Kron Chairman and Chief Executive Officer of ALSTOM signing the Guest Book with the Director-General R. Heuer and visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry. Accompanied by P. Fassnacht throughout.

  13. Senior Senator from Florida and Chairman, Senate Committee on Space, Aeronautics and Related Sciences W. Nelson, visiting the ATLAS cavern and LHC tunnel with ATLAS Collaboration Spokesperson P. Jenni and AMS Collaboration Spokesperson S.C.C.Ting, 16 March 2008.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    Senior Senator from Florida and Chairman, Senate Committee on Space, Aeronautics and Related Sciences W. Nelson, visiting the ATLAS cavern and LHC tunnel with ATLAS Collaboration Spokesperson P. Jenni and AMS Collaboration Spokesperson S.C.C.Ting, 16 March 2008.

  14. Chairman of the DELL Board of Directors and Chief Executive Officer Michael S. Dell with CERN Director-General R. Heuer and in front of the ATLAS detector (centre) with ATLAS Deputy Spokesperson A. Lankford (left) and Information Technology Department Head F. Hemmer on 26th January 2010.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    Chairman of the DELL Board of Directors and Chief Executive Officer Michael S. Dell with CERN Director-General R. Heuer and in front of the ATLAS detector (centre) with ATLAS Deputy Spokesperson A. Lankford (left) and Information Technology Department Head F. Hemmer on 26th January 2010.

  15. 30 January 2012 - Danish National Research Foundation Chairman of board K. Bock and University of Copenhagen Rector R. Hemmingsen visiting ATLAS underground experimental area, CERN Control Centre and ALICE underground experimental area, throughout accompanied by J. Dines Hansen and B. Svane Nielsen; signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci and Head of International Relations F. Pauss.

    CERN Document Server

    Jean-Claude Gadmer

    2012-01-01

    30 January 2012 - Danish National Research Foundation Chairman of board K. Bock and University of Copenhagen Rector R. Hemmingsen visiting ATLAS underground experimental area, CERN Control Centre and ALICE underground experimental area, throughout accompanied by J. Dines Hansen and B. Svane Nielsen; signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci and Head of International Relations F. Pauss.

  16. 25 June 2010 - Founder Chairman of the Japanese Science and Technology in Society Forum K. Omi signing the guest book with Head of International Relations F. Pauss, Adviser J. Ellis and Director-General R. Heuer; in the ATLAS visitor centre with Former Collaboration Spokesperson P. Jenni.

    CERN Multimedia

    2010-01-01

    25 June 2010 - Founder Chairman of the Japanese Science and Technology in Society Forum K. Omi signing the guest book with Head of International Relations F. Pauss, Adviser J. Ellis and Director-General R. Heuer; in the ATLAS visitor centre with Former Collaboration Spokesperson P. Jenni.

  17. 19 July 2013 - Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research E. Celis visiting the ATLAS experimental cavern with ATLAS Collaboration Deputy Spokesperson, B. Heinemann and signing the Guest Book with Director for Accelerators and Technology S. Myers. Life Sciences Adviser M. Dosanjh present.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    19 July 2013 - Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research E. Celis visiting the ATLAS experimental cavern with ATLAS Collaboration Deputy Spokesperson, B. Heinemann and signing the Guest Book with Director for Accelerators and Technology S. Myers. Life Sciences Adviser M. Dosanjh present.

  18. 2 March 2012 - US Google Management Team Executive Chairman E. Schmidt visiting the LHC superconducting magnet test hall with Director for Accelerators and Technology S. Myers and Head of Technology Department F. Bordry; signing the guest book with CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    2 March 2012 - US Google Management Team Executive Chairman E. Schmidt visiting the LHC superconducting magnet test hall with Director for Accelerators and Technology S. Myers and Head of Technology Department F. Bordry; signing the guest book with CERN Director-General R. Heuer.

  19. Ian Taylor MBE MP Chairman Parliamentary and Scientific Committee, United Kingdom (second from left) with (from left to right) CMS Technical Coordinator A. Ball, CMS Spokesperson Tejinder (Jim) Virdee and Adviser to the Director-General J. Ellis on 2 November 2009.

    CERN Multimedia

    Maximilien Brice; CMS

    2009-01-01

    Ian Taylor MBE MP Chairman Parliamentary and Scientific Committee, United Kingdom (second from left) with (from left to right) CMS Technical Coordinator A. Ball, CMS Spokesperson Tejinder (Jim) Virdee and Adviser to the Director-General J. Ellis on 2 November 2009.

  20. 13 February 2012 - World Economic Forum Founder and Executive Chairman K. Schwab and Chairperson and Co-Founder Schwab Foundation for Social Entrepreneurship H. Schwab (Mrs)in the ATLAS experimental area at LHC Point 1 with Collaboration Former Spokesperson P. Jenni; signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    13 February 2012 - World Economic Forum Founder and Executive Chairman K. Schwab and Chairperson and Co-Founder Schwab Foundation for Social Entrepreneurship H. Schwab (Mrs)in the ATLAS experimental area at LHC Point 1 with Collaboration Former Spokesperson P. Jenni; signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss.

  1. 21 September 2010 - Chairman of the Pakistan Atomic Energy Commission A. Parvez, CERN Director-General R. Heuer, Staff Association President G. Deroma, Ambassador to the UN Z. Akram (showing a symbol of the funds raised by CERN Staff for Pakistan)and Adviser for Non-Member States R. Voss.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    21 September 2010 - Chairman of the Pakistan Atomic Energy Commission A. Parvez, CERN Director-General R. Heuer, Staff Association President G. Deroma, Ambassador to the UN Z. Akram (showing a symbol of the funds raised by CERN Staff for Pakistan)and Adviser for Non-Member States R. Voss.

  2. Moving Forward Vice Straight Ahead

    Science.gov (United States)

    2010-03-25

    Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an...College is accredited by the Commission on Higher Education of the Middle States Association of Colleges and Schools, 3624 Market Street, Philadelphia...Public schools recognize their duty to educate and protect gay, lesbian, bisexual and transgender students.17 It is no longer uncommon to see gay

  3. Diversidad florística y conservación del Santuario Regional de Piura Manglares San Pedro de Vice-Sechura

    Directory of Open Access Journals (Sweden)

    Manuel Charcape-Ravelo

    2013-05-01

    Full Text Available El presente trabajo se llevó a cabo con la finalidad de conocer la composición de las fanerógamas del Santuario Regional de Piura Manglares San Pedro de Vice-Sechura. Su importancia radica en que es el manglar más austral del Pacífico de Sudamérica. Dicho trabajo fue realizado desde abril del 2000 hasta febrero del 2004. Para la realización del presente estudio se realizaron visitas periódicas cada dos meses al lugar, se colectaron las plantas bajo procedimientos estándar. Las muestras se determinaron en el lugar y algunas fueron llevadas al laboratorio de Botánica de la Universidad Nacional de Piura y al laboratorio de Botánica Fanerogámica de la Universidad Nacional de Trujillo para su determinación definitiva; luego, las muestras se depositaron en el herbario en formación de la Universidad Nacional de Piura. El manglar consiste en primer lugar de árboles y arbustos de Avicennia germinans (L. L. (Verbenaceae «mangle prieto». En el presente inventario se documentan un total de 44 especies de fanerógamas correspondiendo a 36 géneros en 21 familias para el manglar.

  4. Top man: Mathematician, geographer, vice chancellor , Sir Alan Wilson the new director general of higher education at the DfES, has a reputation for solving complicated problems. He talks to Jim Kelly

    CERN Multimedia

    Kelly, J

    2003-01-01

    "Sir Alan Wilson, vice-chancellor of Leeds University, has made a career out of solving big problems. This week he landed himself one of the biggest. Appointed the government's first ever director general of higher education, he becomes responsible for advising Charles Clarke at a pivotal moment in the history of the sector" (1 page).

  5. 75 FR 70289 - Notice of Appointment of Individuals to Serve as Members of Performance Review Board

    Science.gov (United States)

    2010-11-17

    ... INFORMATION CONTACT: Cynthia Roscoe, Director of Human Resources, U.S. International Trade Commission (202... the PRB: Vice Chairman Irving A. Williamson Vice-Chair of the PRB: Commissioner Daniel R. Pearson...

  6. Are fear-avoidance beliefs in low back pain patients a risk factor for low physical activity or vice versa? A cross-lagged panel analysis

    Science.gov (United States)

    Leonhardt, Corinna; Lehr, Dirk; Chenot, Jean-François; Keller, Stefan; Luckmann, Judith; Basler, Heinz-Dieter; Baum, Erika; Donner-Banzhoff, Norbert; Pfingsten, Michael; Hildebrandt, Jan; Kochen, Michael M.; Becker, Annette

    2009-01-01

    Objective: The assumption that low back pain (LBP) patients suffer from “disuse” as a consequence of high fear-avoidance beliefs is currently under debate. A secondary analysis served to investigate whether fear-avoidance beliefs are associated cross-sectionally and longitudinally with the physical activity level (PAL) in LBP patients. Methods: A total of 787 individuals (57% acute and 43% chronic LBP) were followed up over a period of one year with measurements of fear-avoidance beliefs and physical activity level. Fear-avoidance beliefs concerning physical activity were measured by the physical-activity subscale of the FABQ (Fear-Avoidance Beliefs Questionnaire), the physical activity level was assessed in weighted metabolic equivalents (MET) hours/week with a German self-report questionnaire. Data were investigated by structural equation modelling in a cross-lagged panel design for the whole sample and separately for acute and chronic LBP. Results: The acute and chronic sub sample increased their total physical activity level significantly after one year. The structural equation modelling results did not support the disuse-aspect inherent in the fear-avoidance belief model. Cross-lagged path coefficients were low (.04 and .05 respectively) and, therefore, did not allow to predict final physical activity by initial fear-avoidance beliefs or vice versa. Discussion: Consequently, due to missing links between fear-avoidance beliefs and physical activity in a longitudinal design, the assumptions of the fear-avoidance belief model have to be questioned. These findings are in line with other investigations published recently. Most probably, “fear-avoidance belief” represents a cognitive scheme that does not limit activity per se, but only is directed to the avoidance of specific movements. PMID:19742047

  7. Quantified Event Automata: Towards Expressive and Efficient Runtime Monitors

    Science.gov (United States)

    Barringer, Howard; Falcone, Ylies; Havelund, Klaus; Reger, Giles; Rydeheard, David

    2012-01-01

    Runtime verification is the process of checking a property on a trace of events produced by the execution of a computational system. Runtime verification techniques have recently focused on parametric specifications where events take data values as parameters. These techniques exist on a spectrum inhabited by both efficient and expressive techniques. These characteristics are usually shown to be conflicting - in state-of-the-art solutions, efficiency is obtained at the cost of loss of expressiveness and vice-versa. To seek a solution to this conflict we explore a new point on the spectrum by defining an alternative runtime verification approach.We introduce a new formalism for concisely capturing expressive specifications with parameters. Our technique is more expressive than the currently most efficient techniques while at the same time allowing for optimizations.

  8. Opium: The Evolution of Policies, the Tolerance of the Vice, and the Proliferation of Contraband Trade in the Philippines, 1843-1908

    Directory of Open Access Journals (Sweden)

    Alma N. Bamero

    2006-12-01

    Full Text Available This research entitled “Opium: The Evolution of Policies, the Tolerance of the Vice, and the Proliferation of Contraband Trade in the Philippines, 1843-1908” presents a discussion of the opium trade in Asia, the commercial networks it created, the political ties it strengthened, and the social relations itfostered. It also aims to reconstruct an aspect of Philippine social history in the nineteenth century through the use of archival materials that bear witness to the distribution and exploitation of a substance which some people stillclassify as taboo. The poppy was not endemic to the Philippines but opium, its derivative substance, was known to numb pain and could induce a “natural high” that left one with feelings of ease and contentment. A more complete introduction to the drug necessitates a discussion of the way it was extractedand processed. It is a cash crop that does not require complex devices and is, therefore, within the reach of farmers and common folk. From the eighteenth to the nineteenth centuries opium became very popular among the Chinese who discovered that their markets were being flooded with it by the British sothat the latter could pay for the tea that they craved.The Spanish Bourbons, in an effort to boost Philippine economy, allowed the trading of this substance. Initially this was supervised by the officials of the Alcaiceria de San Fernando but in 1843 the meticulous examination of the country’s finances merited the creation of an opium revenuefarm through municipal franchising. Opium could only be used by the Chinese who were migrating in big groups. This paper presents the details of the monopoly contract, identifies some of the wealthier contratistas of the period, and discusses the consequences of such a commercial venture. Smuggling orcontraband trade proliferated and by way of illustration the events namely, the Scandal of 1843 and the Gunga Incident, have been narrated. The creation of an over

  9. 14th September 2010 - UK Birmingham University Vice Chancellor D. Eastwood signing the guest book with Director for Accelerators and Technology S. Myers (CERN-HI-1009225 13-22)

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    (CERN-HI-1009225 02-12): visiting the LHC superconducting magnet test hall with Beams Department Head P. Collier; (CERN-HI-1009225 27-34): visiting the ATLAS visitor centre with Collaboration Spokesperson F. Gianotti and Deputy D. Charlton, University of Birmingham. D.Eastwood is accompnied by Pro-Vice-Chancellor and Head of College (Engineering and Physical Sciences) N. Weatherill and Head of School, School of Physics & Astronomy A.Schofield.

  10. Path Expressions

    Science.gov (United States)

    1975-06-01

    Traditionally, synchronization of concurrent processes is coded in line by operations on semaphores or similar objects. Path expressions move the...discussion about a variety of synchronization primitives . An analysis of their relative power is found in [3]. Path expressions do not introduce yet...another synchronization primitive . A path expression relates to such primitives as a for- or while-statement of an ALGOL-like language relates to a JUMP

  11. [Remain true to our original aspiration for farewell to the God of Plague, compose the new chapter for the national schistosomiasis control programme scientifically-Commemoration of 60th anniversary of publishing Chairman Mao Zedong's two poems "Farewell to the God of Plague"].

    Science.gov (United States)

    Xiao-Nong, Zhou; Shi-Zhu, Li; Qing-Biao, Hong; Kun, Yang; Shan, Lü; Jing, Xu

    2018-02-26

    This paper reviews the huge promotion of Chairman Mao Zedong's two poems entitled "Farewell to the God of Plague" which were published 60 years ago, and the great achievements of the national schistosomiasis control programme in China. The publication of the two poems promotes the establishment of the mechanism for the national schistosomiasis control programme in China, and in addition, the schistosomiasis control spirit of the people from Yujiang County is still the source of power for the promotion of transferring the schistosomiasis control to elimination stage in China. Now, that we commemorate the 60th anniversary of publishing Chairman Mao Zedong's two poems entitled "Farewell to the God of Plague" means we remain the true to our original aspiration to serve the people forever, which is also to promote the progress of schistosomiasis elimination in China according to the law, the scientific principle, and local conditions, so as to contribute our efforts for realizing the healthy China's dream.

  12. 12 CFR 403.10 - Safeguarding.

    Science.gov (United States)

    2010-01-01

    ... as TOP SECRET. (1) TOP SECRET. Designated as TOP SECRET control officers are the Chairman, Vice Chairman and the Security Officer who alone have authority to receive TOP SECRET information for the Bank. Other personnel authorized in writing by the Chairman or Security Officer also may receive TOP SECRET...

  13. Gene expression

    International Nuclear Information System (INIS)

    Hildebrand, C.E.; Crawford, B.D.; Walters, R.A.; Enger, M.D.

    1983-01-01

    We prepared probes for isolating functional pieces of the metallothionein locus. The probes enabled a variety of experiments, eventually revealing two mechanisms for metallothionein gene expression, the order of the DNA coding units at the locus, and the location of the gene site in its chromosome. Once the switch regulating metallothionein synthesis was located, it could be joined by recombinant DNA methods to other, unrelated genes, then reintroduced into cells by gene-transfer techniques. The expression of these recombinant genes could then be induced by exposing the cells to Zn 2+ or Cd 2+ . We would thus take advantage of the clearly defined switching properties of the metallothionein gene to manipulate the expression of other, perhaps normally constitutive, genes. Already, despite an incomplete understanding of how the regulatory switch of the metallothionein locus operates, such experiments have been performed successfully

  14. 16 CFR 0.8 - The Chairman.

    Science.gov (United States)

    2010-01-01

    ... Commission, are the following staff units: (a) The Office of Public Affairs, which furnishes information concerning Commission activities to news media and the public; and (b) the Office of Congressional Relations...

  15. Integrating Biological Perspectives:. a Quantum Leap for Microarray Expression Analysis

    Science.gov (United States)

    Wanke, Dierk; Kilian, Joachim; Bloss, Ulrich; Mangelsen, Elke; Supper, Jochen; Harter, Klaus; Berendzen, Kenneth W.

    2009-02-01

    Biologists and bioinformatic scientists cope with the analysis of transcript abundance and the extraction of meaningful information from microarray expression data. By exploiting biological information accessible in public databases, we try to extend our current knowledge over the plant model organism Arabidopsis thaliana. Here, we give two examples of increasing the quality of information gained from large scale expression experiments by the integration of microarray-unrelated biological information: First, we utilize Arabidopsis microarray data to demonstrate that expression profiles are usually conserved between orthologous genes of different organisms. In an initial step of the analysis, orthology has to be inferred unambiguously, which then allows comparison of expression profiles between orthologs. We make use of the publicly available microarray expression data of Arabidopsis and barley, Hordeum vulgare. We found a generally positive correlation in expression trajectories between true orthologs although both organisms are only distantly related in evolutionary time scale. Second, extracting clusters of co-regulated genes implies similarities in transcriptional regulation via similar cis-regulatory elements (CREs). Vice versa approaches, where co-regulated gene clusters are found by investigating on CREs were not successful in general. Nonetheless, in some cases the presence of CREs in a defined position, orientation or CRE-combinations is positively correlated with co-regulated gene clusters. Here, we make use of genes involved in the phenylpropanoid biosynthetic pathway, to give one positive example for this approach.

  16. Aznar, Hanotin, and May (eds., À la place du roi. Vice-rois, gouverneurs et ambassadeurs dans les monarchies française et espanole (Casa de Velázquez, 2014

    Directory of Open Access Journals (Sweden)

    Lisandra Estevez

    2016-06-01

    Full Text Available The French and Spanish courts were two of the most powerful cultural and political institutions in seventeenth-century Europe.  Both rivals and allies, the French and Spanish crowns were bound by disputes and diplomacy.  This anthology examines the Gallic and Iberian court systems from a comparative approach, filling an important lacuna in early modern political studies and diplomatic history.  It is based on the proceedings of a seminar held at the Casa de Velázquez, Madrid in June 2010. Edited by Daniel Aznar, Guillaume Hanotin and Niels F. May, À la place du roi. Vice-rois, gouverneurs et ambassadeurs dans les monarchies française et espanole (XVIe-XVIIIe siècles unites ten essays by leading scholars of seventeenth-century French and Spanish history.

  17. 3rd International Symposium Mathematical Progress in Expressive Image Synthesis

    CERN Document Server

    Ochiai, Hiroyuki

    2016-01-01

    “Progress in Expressive Image Synthesis” (MEIS2015), was held in Fukuoka, Japan, September 25–27, 2015. The aim of the symposium was to provide a unique venue where various issues in computer graphics (CG) application fields could be discussed by mathematicians, CG researchers, and practitioners. Through the previous symposiums MEIS2013 and MEIS2014, mathematicians as well as CG researchers have recognized that CG is a specific and practical activity derived from mathematical theories. Issues found in CG broaden the field of mathematics and vice versa, and CG visualizes mathematical theories in an aesthetic manner. In this volume, the editors aim to provoke interdisciplinary research projects through the peer-reviewed papers and poster presentations at the this year’s symposium. This book captures interactions among mathematicians, CG researchers, and practitioners sharing important, state-of-the-art issues in graphics and visual perception. The book is suitable for all CG researchers seeking open pro...

  18. Faces and bodies: perception and mimicry of emotionally congruent and incongruent facial and bodily expressions

    Directory of Open Access Journals (Sweden)

    Mariska eKret

    2013-02-01

    Full Text Available Traditional emotion theories stress the importance of the face in the expression of emotions but bodily expressions are becoming increasingly important. Here we tested the hypothesis that similar physiological responses can be evoked by observing emotional face and body signals and that the reaction to angry signals is amplified in anxious individuals. We designed three experiments in which participants categorized emotional expressions from isolated facial and bodily expressions and from emotionally congruent and incongruent face-body compounds. Participants’ fixations were measured and their pupil size recorded with eye-tracking equipment, and their facial reactions measured with electromyography (EMG. The behavioral results support our prediction that the recognition of a facial expression is improved in the context of a matching posture and importantly, also vice versa. From their facial expression, it appeared that observers acted with signs of negative emotionality (increased corrugator activity to angry and fearful facial expressions and with positive emotionality (increased zygomaticus to happy facial expressions. What we predicted and found, was that angry and fearful cues from the face or the body, attracted more attention than happy cues. We further observed that responses evoked by angry cues were amplified in individuals with high anxiety scores. In sum, we show that people process bodily expressions of emotion in a similar fashion as facial expressions and that the congruency between the emotional signals from the face and body ameliorates the recognition of the emotion.

  19. 5 avril 2016 - J.-C. Marcourt Vice-Président blege du Gouvernement wallon, Ministre de l'Economie, de l'Industrie, de l'Innovation et du Numérique & Vice-Président du Gouvernement de la Fédération Wallonie-Bruxelles, Ministre de l'Enseignement supérieur, de la Recherche et des Médias signe le livre d'or avec le Directeur de la Recherche et du Calcul scientifique E. Elsen; Le chef du département IT F. Hemmer et le chef de la section TE-MSC-CMI J.-P. Tock sont également présents.

    CERN Document Server

    Bennett, Sophia Elizabeth

    2016-01-01

    Monsieur Jean-Claude Marcourt Vice-Président du Gouvernement wallon, Ministre de l'Economie, de l'Industrie, de l'Innovation et du Numérique Vice-Président du Gouvernement de la Fédération Wallonie-Bruxelles, Ministre de l'Enseignement supérieur, de la Recherche et des Médias

  20. Sociology as Moral Philosophy (and Vice Versa).

    Science.gov (United States)

    Vandenberghe, Frédéric

    2017-11-01

    In this article, I want to make an attempt to reconnect sociology to moral philosophy and moral philosophy to sociology. The thesis I want to defend is that sociology continues by other means the venerable tradition of practical and moral philosophy. Like its forebears, it stands and falls with a defense of "practical wisdom" (Aristotle) and "practical reason" (Kant). The development of a moral sociology presupposes, however, that one recognizes and rejects Max Weber's theory of axiological neutrality as an extremist position and that one carefully articulates prescriptive and descriptive, internal and external, as well as observer and actor positions. © 2017 Canadian Sociological Association/La Société canadienne de sociologie.

  1. Bureaucratic Corruption: Efficiency Virtue or Distributive Vice?

    OpenAIRE

    Kulshreshtha Pravin

    2003-01-01

    Governments frequently allocate resources at low prices and on a first-come-first-served basis because of reasons of equity and a concern for the poor. However, bureaucrats who distribute these resources often take bribes. This paper develops a rigorous model to analyze the distributional, efficiency and public policy implications of bribery in such situations. It is shown that at low prices, the poor would choose to wait while the rich would pay the bribe to obtain the rationed commodity. If...

  2. ASPIRING VICE-CHANCELLORS' RHETORIC AND THE ...

    African Journals Online (AJOL)

    problems militating against the effective management of the university system in Nigeria .... political awareness in view of the historical turn at the end of one millennium and ... into account the contingencies of a given place and time and considers the opportunities ..... This view resonates with contemporary thinking about ...

  3. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa visiting ALICE experiment on 1st November 2007 with CERN Director-General R. Aymar and Adviser J.-P. Revol. Thursday, 1st and Friday, 2nd November 2007

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa visiting ALICE experiment on 1st November 2007 with CERN Director-General R. Aymar and Adviser J.-P. Revol. Thursday, 1st and Friday, 2nd November 2007

  4. 15 January 2010 - Vice-Chancellor & Chief Executive C. Snowden, University of Surrey, United Kingdom and Mrs Snowden visiting ALICE exhibition and experimental undeground area with Collabortion Spokesperson J. Schukraft and Beams Department Head P. Collier; Signature of the guest book with CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    15 January 2010 - Vice-Chancellor & Chief Executive C. Snowden, University of Surrey, United Kingdom and Mrs Snowden visiting ALICE exhibition and experimental undeground area with Collabortion Spokesperson J. Schukraft and Beams Department Head P. Collier; Signature of the guest book with CERN Director-General R. Heuer.

  5. 17 October 2013 - C. Ashton High Representative of the European Union for Foreign Affairs and Security Policy, Vice-President of the European Commission visiting the ATLAS cavern with ATLAS Collaboration Spokesperson D. Charlton; visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the Guest book with CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2013-01-01

    17 October 2013 - C. Ashton High Representative of the European Union for Foreign Affairs and Security Policy, Vice-President of the European Commission visiting the ATLAS cavern with ATLAS Collaboration Spokesperson D. Charlton; visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the Guest book with CERN Director-General R. Heuer.

  6. 21 June 2010 - TUBITAK Vice President A. Adli signing the guest book with CERN Director-General R. Heuer, visiting the ATLAS control room at Point 1 with Former Collaboration Spokesperson P. Jenni and CMS Control Centre, building 354, with Collaboration Spokesperson G. Tonelli. Throughout accompanied by Adviser J. Ellis.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    21 June 2010 - TUBITAK Vice President A. Adli signing the guest book with CERN Director-General R. Heuer, visiting the ATLAS control room at Point 1 with Former Collaboration Spokesperson P. Jenni and CMS Control Centre, building 354, with Collaboration Spokesperson G. Tonelli. Throughout accompanied by Adviser J. Ellis.

  7. 21 January 2008 - Vice-President of the Human Rights Commission Z. Muhsin Al Hussein, Ambassador to United Nations A. Attar and their delegation from Saudi Arabia, visiting the ATLAS experimental cavern with Collaboration Spokesperson P. Jenni and Technical Coordinator M. Nessi.

    CERN Multimedia

    Claudia Marcelloni

    2008-01-01

    21 January 2008 - Vice-President of the Human Rights Commission Z. Muhsin Al Hussein, Ambassador to United Nations A. Attar and their delegation from Saudi Arabia, visiting the ATLAS experimental cavern with Collaboration Spokesperson P. Jenni and Technical Coordinator M. Nessi.

  8. 16 December 2013 - Hooke Professor of Experimental Physics and Pro Vice Chancellor University of Oxford Prof. I. Walmsley visiting the ATLAS cavern with ATLAS Collaboration Deputy Spokesperson T. Wengler, Physics Department, ATLAS Collaboration P. Wells and Chair, CMS Collaboration Board, Oxford University and Purdue University I. Shipsey

    CERN Document Server

    Anna Pantelia

    2013-01-01

    16 December 2013 - Hooke Professor of Experimental Physics and Pro Vice Chancellor University of Oxford Prof. I. Walmsley visiting the ATLAS cavern with ATLAS Collaboration Deputy Spokesperson T. Wengler, Physics Department, ATLAS Collaboration P. Wells and Chair, CMS Collaboration Board, Oxford University and Purdue University I. Shipsey

  9. 23rd May 2011 - University of Liverpool Pro-Vice-Chancellor and Public Orator K. Everest (UK) Mrs Everest in the ATLAS visitor centre with Collaboration Deputy Spokesperson D. Charlton, in LHCb surface building with Collaboration Spokesperson A. Golutvin, accompanied throughout by P. Wells and Liverpool University T. Bowcock and M. Klein.

    CERN Multimedia

    Maximilen Brice

    2011-01-01

    23rd May 2011 - University of Liverpool Pro-Vice-Chancellor and Public Orator K. Everest (UK) Mrs Everest in the ATLAS visitor centre with Collaboration Deputy Spokesperson D. Charlton, in LHCb surface building with Collaboration Spokesperson A. Golutvin, accompanied throughout by P. Wells and Liverpool University T. Bowcock and M. Klein.

  10. 2nd September 2010 - Japanese Senior Vice-Minister of the Environment I. Tajima signing the guest book with Director-General R. Heuer and visiting the ATLAS control room with physicists T. Kondo and H. Fukuda, Members of the ATLAS Collaboration and KEK.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    2nd September 2010 - Japanese Senior Vice-Minister of the Environment I. Tajima signing the guest book with Director-General R. Heuer and visiting the ATLAS control room with physicists T. Kondo and H. Fukuda, Members of the ATLAS Collaboration and KEK.

  11. 6 March 2013 - Committee for Employment and Learning, Northern Ireland Legislative Assembly, United Kingdom of Great Britain and Northern Ireland in the LHC tunnel and visiting the LHCb experiment at LHC Point 8. Director for Accelerators and Technology S. Myers with Vice-Chair T. Buchanan.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    6 March 2013 - Committee for Employment and Learning, Northern Ireland Legislative Assembly, United Kingdom of Great Britain and Northern Ireland in the LHC tunnel and visiting the LHCb experiment at LHC Point 8. Director for Accelerators and Technology S. Myers with Vice-Chair T. Buchanan.

  12. 27 November 2014 - Warsaw University of Technology (PL) Vice-Rector for Research R. Bacewicz visitng the ALICE control room and undergorund experimental area with WUT students, accompanied by A. Charkiewicz and A. Siemko; joint signature ceremony with HNINP Director-General M. Jezabek

    CERN Multimedia

    Guillaume, Jeanneret

    2014-01-01

    CERN-PHOTO-201411-245-95: from left to right: Professor D.Sc.Ph.D. Rajmund Bacewicz, Vice-Rector for Research, Warsaw University of Technology, CERN Director-General R. Heuer and Prof. Marek Jeżabek, Director-General, Henryk Niewodniczanski Institute of Nuclear Physics, Republic of Poland

  13. 19 January 2011 - Korean Vice Minister II of Education, Science and Technology K.Chang-Kyung with Adviser R. Voss, Director-General R. Heuer and head of International Relations F. Pauss; in the LHC tunnel at Point 5 and CMS experimental cavern with Collaboration Spokesperson G. Tonelli.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Korean vice-minister II of education, science and technology, Kim Chang-Kyung, visiting the CMS experimental area at CERN on 19 January. He also had the opportunity to view part of the LHC tunnel, as well as to visit the CERN Control Centre.

  14. 11 July 2011 - Carleton University Ottawa, Canada Vice President (Research and International) K. Matheson in the ATLAS visitor centre with Collaboration Spokesperson F. Gianotti, accompanied by Adviser J. Ellis and signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci.

    CERN Multimedia

    Jean-Claude Gadmer

    2011-01-01

    11 July 2011 - Carleton University Ottawa, Canada Vice President (Research and International) K. Matheson in the ATLAS visitor centre with Collaboration Spokesperson F. Gianotti, accompanied by Adviser J. Ellis and signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci.

  15. Monsieur Etienne Blanc Premier vice-président de la Région Auvergne-Rhône-Alpes Délégué aux finances, à l'administration générale, aux économies budgétaires et aux politiques transfrontalières

    CERN Multimedia

    Bennett, Sophia Elizabeth

    2017-01-01

    Monsieur Etienne Blanc Premier vice-président de la Région Auvergne-Rhône-Alpes Délégué aux finances, à l'administration générale, aux économies budgétaires et aux politiques transfrontalières

  16. 17 January 2014 - Y. Sakurada Japanese Senior Vice Minister of Education, Culture, Sports, Science and Technology signing the Guest book with CERN Director-General R. Heuer and visiting the LHC tunnel at Point 1 with Technology Department Head J.M. Jiménez. Head of International Relations R. Voss present throughout.

    CERN Multimedia

    Pantelia, Anna

    2014-01-01

    17 January 2014 - Y. Sakurada Japanese Senior Vice Minister of Education, Culture, Sports, Science and Technology signing the Guest book with CERN Director-General R. Heuer and visiting the LHC tunnel at Point 1 with Technology Department Head J.M. Jiménez. Head of International Relations R. Voss present throughout.

  17. 30 January 2012 - Ecuadorian Ambassador Gallegos Chiriboga, Permanent Representative to the United Nations Office and other International Organisations at Geneva and San Francisco de Quito University Vice Chancellor C. Montùfar visiting CMS surface facilities and underground experimental area with CMS Collaboration L. Sulak and Collaboration Deputy Spokesperson T. Camporesi, throughout accompanied by Head of International Relations F. Pauss.

    CERN Multimedia

    Michael Hoch

    2012-01-01

    30 January 2012 - Ecuadorian Ambassador Gallegos Chiriboga, Permanent Representative to the United Nations Office and other International Organisations at Geneva and San Francisco de Quito University Vice Chancellor C. Montùfar visiting CMS surface facilities and underground experimental area with CMS Collaboration L. Sulak and Collaboration Deputy Spokesperson T. Camporesi, throughout accompanied by Head of International Relations F. Pauss.

  18. 30 August 2013 - Senior Vice Minister for Foreign Affairs in Japan M. Matsuyama signing the guest book with CERN Director-General; visit the ATLAS experimental cavern with ATLAS Spokesperson D. Charlton and visiting the LHC tunnel at Point 1 with former ATLAS Japan national contact physicist T. Kondo. R. Voss and K. Yoshida present throughout.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    30 August 2013 - Senior Vice Minister for Foreign Affairs in Japan M. Matsuyama signing the guest book with CERN Director-General; visit the ATLAS experimental cavern with ATLAS Spokesperson D. Charlton and visiting the LHC tunnel at Point 1 with former ATLAS Japan national contact physicist T. Kondo. R. Voss and K. Yoshida present throughout.

  19. Chinese Food Heats Up

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Earlier this year,the vice chairman of industry body the China Cuisine Association,Yang Liu,expressed his bewilderment at the absence of a truly successful Chinese restaurant chain."In this ancient nation with a restaurant culture thousands of years old,home to the most delicious food in the world,it is a pity that you can find world-famous traditional dishes and delicious snacks,but a globally competitive restaurant chain is nowhere to be found,"he told Sanlian Life Weekly.

  20. 75 FR 9415 - Notice of Hearing Schedule; Passenger Vessel Financial Responsibility

    Science.gov (United States)

    2010-03-02

    ... Inc...... Charles A. Robertson, 15 Chairman & Chief Executive Officer. Carnival Corporation & PLC..... David Bernstein, Senior 15 Vice President & Chief Financial Officer. Crystal Cruises, Inc Ann G. Miller... FEDERAL MARITIME COMMISSION Notice of Hearing Schedule; Passenger Vessel Financial Responsibility...

  1. 75 FR 20350 - Announcement of the Board of Trustees for the National Environmental Education Foundation

    Science.gov (United States)

    2010-04-19

    ... include: JL Armstrong (NEEF Vice Chair), National Manger, Toyota Motor Sales, USA, Inc. Raymond Ban..., Environment, Health and Safety, Baxter. Healthcare Corporation. Kenneth Olden, Chairman, Avon Foundation... Corporation. Diane Wood (NEEF Secretary), President, National Environmental Education Foundation. Background...

  2. About the Joint Chiefs of Staff

    Science.gov (United States)

    Skip to main content (Press Enter). Toggle navigation Joint Chiefs of Staff Joint Chiefs of Staff Joint Chiefs of Staff Facebook Twitter YouTube Flickr Blog Instagram Search JCS: Search Search Search JCS: Search Home Media News Photos Videos Publications About The Joint Staff Chairman Vice Chairman

  3. Official Website of the Joint Chiefs of Staff

    Science.gov (United States)

    Skip to main content (Press Enter). Toggle navigation Joint Chiefs of Staff Joint Chiefs of Staff Joint Chiefs of Staff Facebook Twitter YouTube Flickr Blog Instagram Search JCS: Search Search Search JCS: Search Home Media News Photos Videos Publications About The Joint Staff Chairman Vice Chairman

  4. Joint Chiefs of Staff > About > The Joint Staff > Senior Enlisted Advisor

    Science.gov (United States)

    Skip to main content (Press Enter). Toggle navigation Joint Chiefs of Staff Joint Chiefs of Staff Joint Chiefs of Staff Facebook Twitter YouTube Flickr Blog Instagram Search JCS: Search Search Search JCS: Search Home Media News Photos Videos Publications About The Joint Staff Chairman Vice Chairman

  5. 33 CFR 210.5 - Rules of the Corps of Engineers Board of Contract Appeals for cases subject to the Contract...

    Science.gov (United States)

    2010-07-01

    ... election. After filing of the Government's answer or notice from the Board that it has entered a general... apply to the Court through the Attorney General of the United States for an order requiring the person.... (ii) The Board consists of a chairman, vice chairman, and other members, all of whom are attorneys at...

  6. “And You, Vampire, Admiral Napier, Don’t Expect the Banquet”. The Case on the Surveillance of the British Vice-Admiral Sir Charles Napier in St. Petersburg in 1856

    Directory of Open Access Journals (Sweden)

    Aleksandr A. Orlov

    2016-12-01

    Full Text Available The Crimean War of 1853-1856 provoked the hostility between the Russian and the English peoples. This had contributed to the confrontational thinking in the consciousness of the two peoples. The changes in mentality had for a long time been anchored through the efforts of the authorities and the media of that time (newspapers, magazines and cartoons. Military operations had led to the fact that their members had realized the disparity of the imposed stereotypes. Disappointment with propaganda clichés prompted some British to think over the reason for their personal failure, to get acquainted closer with the life of former enemies and to inform the public of their country about truth. The author carries out the analysis of unpublished archival documents from the State Archive of the Russian Federation (GA RF, which allow talking about the visit of former commander of the Baltic squadron of the English fleet, Vice-Admiral Ch.J. Napier to St. Petersburg in July 1856, and the surveillance of him by the Russian security police. Ch. J. Napier, motivated by the concepts of personal honour, aimed to get the Russian authorities’ confirmation of the correctness of his actions in the maritime campaign of 1854. He partially succeeded, but the Emperor Alexander II was not willing to meet with him. Ch.J. Napier had not succeeded in gaining justification from the British authorities either. Apparently, neither Russian nor British government no longer needed a positive image of the other country. The Russian-British relations had been tense (or worse throughout the rest part of the 19th century. Russia reoriented to France and (to a lesser extent to the United States, while Britain found itself at the threshold of the “splendid isolation” era. Only the appearance of Germany as a dangerous enemy, which had established at the borders of the British colonial possessions in different parts of the world and had finally broken the “balance of powers” in

  7. Express web application development

    CERN Document Server

    Yaapa, Hage

    2013-01-01

    Express Web Application Development is a practical introduction to learning about Express. Each chapter introduces you to a different area of Express, using screenshots and examples to get you up and running as quickly as possible.If you are looking to use Express to build your next web application, ""Express Web Application Development"" will help you get started and take you right through to Express' advanced features. You will need to have an intermediate knowledge of JavaScript to get the most out of this book.

  8. Sialyl Lewis x expression in canine malignant mammary tumours: correlation with clinicopathological features and E-Cadherin expression

    International Nuclear Information System (INIS)

    Pinho, Salomé S; Matos, Augusto JF; Lopes, Célia; Marcos, Nuno T; Carvalheira, Júlio; Reis, Celso A; Gärtner, Fátima

    2007-01-01

    Sialyl Lewis x (sLe x ) antigen is a carbohydrate antigen that is considered not only a marker for cancer but also implicated functionally in the malignant behaviour of cancer cells. Overexpression of sLe x is associated with enhanced progression and metastases of many types of cancer including those of the mammary gland. Canine mammary tumours can invade and give rise to metastases via either lymphatic or blood vessels. E-Cadherin is specifically involved in epithelial cell-to-cell adhesion. In cancer, E-Cadherin underexpression is one of the alterations that characterizes the invasive phenotype and is considered an invasion/tumour suppressor gene. Partial or complete loss of E-Cadherin expression correlates with poor prognosis in canine malignant mammary cancer. The aim of this study was to analyse the sLe x expression in canine malignant mammary tumours and to evaluate if the presence of sLe x correlates with the expression of E-Cadherin and with clinicopathological features. Fifty-three cases of canine mammary carcinomas were analysed immunohistochemically using monoclonal antibodies against sLe x (IgM) and E-Cadherin (IgG). The clinicopathological data were then assessed to determine whether there was a correlation with sLe x tumour expression. Double labelled immunofluorescence staining was performed to analyse the combined expression of sLe x and E-Cadherin. sLe x expression was consistently demonstrated in all cases of canine mammary carcinomas with different levels of expression. We found a significant relationship between the levels of sLe x expression and the presence of lymph node metastases. We also demonstrated that when E-Cadherin expression was increased sLe x was reduced and vice-versa. The combined analysis of both adhesion molecules revealed an inverse relationship. In the present study we demonstrate the importance of sLe x in the malignant phenotype of canine malignant mammary tumours. Our results support the use of sLe x as a prognostic tumour

  9. La Création du Vice Secrétariat de l’Education Populaire La creación de la Vicesecretaría de Educación Popular The creation of Vicesecretaría de Educación Popular

    Directory of Open Access Journals (Sweden)

    Marie-Aline Barrachina

    2009-01-01

    Full Text Available La creación (20-05-1941, de la Vice Secretaría de la Educación Popular, pone un punto final a las ambiciones totalitarias de los falangistas, marca su  definitiva derrota y la ineluctable instrumentalización de sus talentos propagandísticos. El proceso se realiza en tres etapas: desde el decreto de Unificación (19-04-1937, hasta el primer gobierno civil del régimen de Franco (31-01-1938; desde este mismo primer gobierno civil hasta la consolidación de la influencia de Serrano Súnyer (16-11-1940, acceso de Serrano a la cartera de relaciones internacionales; por fin, desde esta fecha, a la creación de la Vice Secretaría. El proceso consistió en externalizar las competencias intelectuales falangistas en un primer tiempo, de manera que no puedan actuar dentro de la administración del Movimiento sino directamente bajo el control del Estado (1937. Luego, en una segunda etapa, se instrumentalizaron estas competencias para organizar las estructuras administrativas de propaganda del nuevo Estado (1938-1940. Por fin, cuando ya estaba confirmada su total sumisión (1941, se devolvió a la administración del Movimiento su vocación inicial de propaganda, creando la Vice Secretaría. A finales de 1943, la Vice Secretaría ya es una enorme máquina administrativa generadora de empleos y sometida al Estado. Su traspaso en 1945 al Ministerio de la Educación — entonces entre las manos de los conservadores católicos— confirma que la era de los funcionarios del franquismo ya se ha sustituido a la de los militantes falangistas.

  10. Investigating the Correspondence Between Transcriptomic and Proteomic Expression Profiles Using Coupled Cluster Models

    International Nuclear Information System (INIS)

    Rogers, Simon; Girolami, Mark; Kolch, Walter; Waters, Katrina M.; Liu, Tao; Thrall, Brian D.; Wiley, H. S.

    2008-01-01

    Modern transcriptomics and proteomics enable us to survey the expression of RNAs and proteins at large scales. While these data are usually generated and analyzed separately, there is an increasing interest in comparing and co-analyzing transcriptome and proteome expression data. A major open question is whether transcriptome and proteome expression is linked and how it is coordinated. Results: Here we have developed a probabilistic clustering model that permits analysis of the links between transcriptomic and proteomic profiles in a sensible and flexible manner. Our coupled mixture model defines a prior probability distribution over the component to which a protein profile should be assigned conditioned on which component the associated mRNA profile belongs to. By providing probabilistic assignments this approach sits between the two extremes of concatenating the data on the assumption that mRNA and protein clusters would have a one-to-one relationship, and independent clustering where the mRNA profile provides no information on the protein profile and vice-versa. We apply this approach to a large dataset of quantitative transcriptomic and proteomic expression data obtained from a human breast epithelial cell line (HMEC) stimulated by epidermal growth factor (EGF) over a series of timepoints corresponding to one cell cycle. The results reveal a complex relationship between transcriptome and proteome with most mRNA clusters linked to at least two protein clusters, and vice versa. A more detailed analysis incorporating information on gene function from the gene ontology database shows that a high correlation of mRNA and protein expression is limited to the components of some molecular machines, such as the ribosome, cell adhesion complexes and the TCP-1 chaperonin involved in protein folding. Conclusions: The dynamic regulation of the transcriptome and proteome in mammalian cells in response to an acute mitogenic stimulus appears largely independent with very little

  11. After Effects expressions

    CERN Document Server

    Geduld, Marcus

    2013-01-01

    Put the power of Expressions to work in your animations with controls and efficiencies impossible to achieve with traditional keyframing techniques. No programming skills are required. Foundation concepts and skills orient the new designer and serve as a handy reference to the experienced one. Basics of creating expressions, variables, commands, and expression helpers precede the leap into javascript and math essentials for more advanced expressions that include randomness, physical simularions and 3D. Full color illustrations display the scripts and the resulti

  12. Neuroglobin over expressing mice

    DEFF Research Database (Denmark)

    Raida, Zindy; Hundahl, Christian Ansgar; Nyengaard, Jens R

    2013-01-01

    showed over expression to be confined to primarily the cortex, hippocampus, cerebellum, and only in neurons. The level and expression pattern of endogenous Neuroglobin was unaffected by insertion of the over expressing Ngb transgene. Neuroglobin over expression resulted in a significant reduction...... previous reports, Neuroglobin over expression is not global but confined to a few well-defined brain regions, and only in neurons. This study confirms previous reports showing a correlation between reduced infarct volume and elevated Neuroglobin levels, but underlines the need to study the likely...

  13. Regular Expression Pocket Reference

    CERN Document Server

    Stubblebine, Tony

    2007-01-01

    This handy little book offers programmers a complete overview of the syntax and semantics of regular expressions that are at the heart of every text-processing application. Ideal as a quick reference, Regular Expression Pocket Reference covers the regular expression APIs for Perl 5.8, Ruby (including some upcoming 1.9 features), Java, PHP, .NET and C#, Python, vi, JavaScript, and the PCRE regular expression libraries. This concise and easy-to-use reference puts a very powerful tool for manipulating text and data right at your fingertips. Composed of a mixture of symbols and text, regular exp

  14. Regular expressions cookbook

    CERN Document Server

    Goyvaerts, Jan

    2009-01-01

    This cookbook provides more than 100 recipes to help you crunch data and manipulate text with regular expressions. Every programmer can find uses for regular expressions, but their power doesn't come worry-free. Even seasoned users often suffer from poor performance, false positives, false negatives, or perplexing bugs. Regular Expressions Cookbook offers step-by-step instructions for some of the most common tasks involving this tool, with recipes for C#, Java, JavaScript, Perl, PHP, Python, Ruby, and VB.NET. With this book, you will: Understand the basics of regular expressions through a

  15. Expression of the Foraging Gene Is Associated with Age Polyethism, Not Task Preference, in the Ant Cardiocondyla obscurior.

    Directory of Open Access Journals (Sweden)

    Jan Oettler

    Full Text Available One of the fundamental principles of social organization, age polyethism, describes behavioral maturation of workers leading to switches in task preference. Here we present a system that allows for studying division of labor (DOL by taking advantage of the relative short life of Cardiocondyla obscurior workers and thereby the pace of behavioral transitions. By challenging same-age young and older age cohorts to de novo establish DOL into nurse and foraging tasks and by forcing nurses to precociously become foragers and vice versa we studied expression patterns of one of the best known candidates for social insect worker behavior, the foraging gene. Contrary to our expectations we found that foraging gene expression correlates with age, but not with the task foraging per se. This suggests that this nutrition-related gene, and the pathways it is embedded in, correlates with physiological changes over time and potentially primes, but not determines task preference of individual workers.

  16. Pseudogenes regulate parental gene expression via ceRNA network.

    Science.gov (United States)

    An, Yang; Furber, Kendra L; Ji, Shaoping

    2017-01-01

    The concept of competitive endogenous RNA (ceRNA) was first proposed by Salmena and colleagues. Evidence suggests that pseudogene RNAs can act as a 'sponge' through competitive binding of common miRNA, releasing or attenuating repression through sequestering miRNAs away from parental mRNA. In theory, ceRNAs refer to all transcripts such as mRNA, tRNA, rRNA, long non-coding RNA, pseudogene RNA and circular RNA, because all of them may become the targets of miRNA depending on spatiotemporal situation. As binding of miRNA to the target RNA is not 100% complementary, it is possible that one miRNA can bind to multiple target RNAs and vice versa. All RNAs crosstalk through competitively binding to miRNAvia miRNA response elements (MREs) contained within the RNA sequences, thus forming a complex regulatory network. The ratio of a subset of miRNAs to the corresponding number of MREs determines repression strength on a given mRNA translation or stability. An increase in pseudogene RNA level can sequester miRNA and release repression on the parental gene, leading to an increase in parental gene expression. A massive number of transcripts constitute a complicated network that regulates each other through this proposed mechanism, though some regulatory significance may be mild or even undetectable. It is possible that the regulation of gene and pseudogene expression occurring in this manor involves all RNAs bearing common MREs. In this review, we will primarily discuss how pseudogene transcripts regulate expression of parental genes via ceRNA network and biological significance of regulation. © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  17. Defense.gov Special Report: Warrior Care Month - 2013

    Science.gov (United States)

    Operation Base Shank, Afghanistan, May 6, 2012. Story Vice Chairman Joins Warriors for Softball Classic Navy single during his final time at bat during the third annual Wounded Warriors Celebrity Softball Classic Wounded Warriors Celebrity Softball Classic in Washington D.C. Story Army Vice Chief, Warriors Share Their

  18. 12 CFR 403.8 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Appeals. 403.8 Section 403.8 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES CLASSIFICATION, DECLASSIFICATION, AND SAFEGUARDING OF NATIONAL... Vice President & Vice Chairman, Export-Import Bank of the United States, 811 Vermont Avenue NW...

  19. Darwin and Emotion Expression

    Science.gov (United States)

    Hess, Ursula; Thibault, Pascal

    2009-01-01

    In his book "The Expression of the Emotions in Man and Animals," Charles Darwin (1872/1965) defended the argument that emotion expressions are evolved and adaptive (at least at some point in the past) and serve an important communicative function. The ideas he developed in his book had an important impact on the field and spawned rich domains of…

  20. Freedom of Expression.

    Science.gov (United States)

    Update on Law-Related Education, 1988

    1988-01-01

    Presents an activity which uses hypothetical situations to explore the proper boundaries of freedom of expression and the role of the U.S. Supreme Court in interpreting its limits. Appropriate for grades 4-12, the lesson includes such topics as the "clear and present danger" clause, student expression, obscenity, and defamation. (GEA)

  1. Caricaturing facial expressions.

    Science.gov (United States)

    Calder, A J; Rowland, D; Young, A W; Nimmo-Smith, I; Keane, J; Perrett, D I

    2000-08-14

    The physical differences between facial expressions (e.g. fear) and a reference norm (e.g. a neutral expression) were altered to produce photographic-quality caricatures. In Experiment 1, participants rated caricatures of fear, happiness and sadness for their intensity of these three emotions; a second group of participants rated how 'face-like' the caricatures appeared. With increasing levels of exaggeration the caricatures were rated as more emotionally intense, but less 'face-like'. Experiment 2 demonstrated a similar relationship between emotional intensity and level of caricature for six different facial expressions. Experiments 3 and 4 compared intensity ratings of facial expression caricatures prepared relative to a selection of reference norms - a neutral expression, an average expression, or a different facial expression (e.g. anger caricatured relative to fear). Each norm produced a linear relationship between caricature and rated intensity of emotion; this finding is inconsistent with two-dimensional models of the perceptual representation of facial expression. An exemplar-based multidimensional model is proposed as an alternative account.

  2. Diversification of gene expression during formation of static submerged biofilms by Escherichia coli

    Directory of Open Access Journals (Sweden)

    Olga Besharova

    2016-10-01

    Full Text Available Many bacteria primarily exist in nature as structured multicellular communities, so called biofilms. Biofilm formation is a highly regulated process that includes the transition from the motile planktonic to sessile biofilm lifestyle. Cellular differentiation within a biofilm is a commonly accepted concept but it remains largely unclear when, where and how exactly such differentiation arises. Here we used fluorescent transcriptional reporters to quantitatively analyze spatio-temporal expression patterns of several groups of genes during the formation of submerged Escherichia coli biofilms in an open static system. We first confirm that formation of such submerged biofilms as well as pellicles at the liquid-air interface requires the major matrix component, curli, and flagella-mediated motility. We further demonstrate that in this system, diversification of gene expression leads to emergence of at least three distinct subpopulations of E. coli, which differ in their levels of curli and flagella expression, and in the activity of the stationary phase sigma factor σS. Our study reveals mutually exclusive expression of curli fibers and flagella at the single cell level, with high curli levels being confined to dense cell aggregates/microcolonies and flagella expression showing an opposite expression pattern. Interestingly, despite the known σS-dependence of curli induction, there was only a partial correlation between the σS activity and curli expression, with subpopulations of cells having high σS activity but low curli expression and vice versa. Finally, consistent with different physiology of the observed subpopulations, we show striking differences between the growth rates of cells within and outside of aggregates.

  3. Neuron-Enriched Gene Expression Patterns are Regionally Anti-Correlated with Oligodendrocyte-Enriched Patterns in the Adult Mouse and Human Brain.

    Science.gov (United States)

    Tan, Powell Patrick Cheng; French, Leon; Pavlidis, Paul

    2013-01-01

    An important goal in neuroscience is to understand gene expression patterns in the brain. The recent availability of comprehensive and detailed expression atlases for mouse and human creates opportunities to discover global patterns and perform cross-species comparisons. Recently we reported that the major source of variation in gene transcript expression in the adult normal mouse brain can be parsimoniously explained as reflecting regional variation in glia to neuron ratios, and is correlated with degree of connectivity and location in the brain along the anterior-posterior axis. Here we extend this investigation to two gene expression assays of adult normal human brains that consisted of over 300 brain region samples, and perform comparative analyses of brain-wide expression patterns to the mouse. We performed principal components analysis (PCA) on the regional gene expression of the adult human brain to identify the expression pattern that has the largest variance. As in the mouse, we observed that the first principal component is composed of two anti-correlated patterns enriched in oligodendrocyte and neuron markers respectively. However, we also observed interesting discordant patterns between the two species. For example, a few mouse neuron markers show expression patterns that are more correlated with the human oligodendrocyte-enriched pattern and vice-versa. In conclusion, our work provides insights into human brain function and evolution by probing global relationships between regional cell type marker expression patterns in the human and mouse brain.

  4. 29 March 2012 - Austrian Niederösterreich Governor E. Pröll with Klubobmann and Chairman of EBG MedAustron GmbH Council K. Schneeberger, Director General for Cultural Policy Amabssador M.Eichtinger and Permanent Representative of Austria to the UNO and Austrian Delegate to CERN Council Ambassador C. Strohal in the MedAustron facility at CERN building 184.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    CERN-HI-1203078 01 - 13: visit of LINAC 3 with M. Benedikt CERN-HI-1203078 14 - 20: in the Roy Billinge room CERN-HI-1203078 21- 22: visit of the LEIR accelerator in building 354 CERN-HI-1203078 23 - 55: signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss CERN-HI-1203078 56 - 99: in building 184, Governor Pröll and CERN Director-General R. Heuer switch on the MedAustron ion source to produce the proton beam; visit MedAustron facility. CERN-HI-1203078 32:from left to right: Klubobmann and Chairman of EBG MedAustron GmbH Council K. Schneeberger; Director-General R. Heuer;Niederösterreich Governor E. Pröll;Head of International Relations F. Pauss;Permanent Representative of Austria to the UNO and Austrian Delegate to CERN Council Ambassador C. Strohal.

  5. Materiality for Musical Expressions

    DEFF Research Database (Denmark)

    Lindell, Rikard; Tahiroğlu, Koray; Riis, Morten S.

    2016-01-01

    Nordic universities. Electronic music instrument makers participated in providing the course. In eleven days the students designed and built interfaces for musical expressions , composed a piece, and performed at the Norberg electronic music festival. The students explored the relationship between......We organised an elven day intense course in materiality for musical expressions to explore underlying principles of New Interfaces for Musical Expression (NIME) in higher education. We grounded the course in different aspects of ma-teriality and gathered interdisciplinary student teams from three...... technology and possible musical expression with a strong connection to culture and place. The emphasis on performance provided closure and motivated teams to move forward in their design and artistic processes. On the basis of the course we discuss an interdisciplinary NIME course syllabus, and we infer...

  6. Localizing Expression of Ambiguity

    National Research Council Canada - National Science Library

    Bear, John; Hobbs, Sr, Jerry R

    1987-01-01

    In this paper we describe an implemented program for localizing the expression of many types of syntactic ambiguity, in the logical forms of sentences, in a manner convenient for subsequent inferential processing...

  7. Gene Expression Omnibus (GEO)

    Data.gov (United States)

    U.S. Department of Health & Human Services — Gene Expression Omnibus is a public functional genomics data repository supporting MIAME-compliant submissions of array- and sequence-based data. Tools are provided...

  8. Express.js blueprints

    CERN Document Server

    Augarten, Ben; Lin, Eric; Shaikh, Aidha; Soriani, Fabiano Pereira; Tisserand, Geoffrey; Zhang, Chiqing; Zhang, Kan

    2015-01-01

    This book is for beginners to Node.js and also for those who are technically advanced. By the end of this book, every competent developer will have achieved expertise in building web applications with Express.js.

  9. CONCLUDING ADDRESS Mr Chairman, ladies and gentlemen, It ...

    African Journals Online (AJOL)

    Beyond this, there was a spectrum of papers on details of the biology, feeding habits, ... It forms the basis for an understanding of biology and I hope that it is .... encroachment have different tasks, but if one link breaks, the whole chain fails. ... The resources are limited and conservation will, for better or for worse, have.

  10. 49 CFR 1007.9 - Appeals to the Chairman.

    Science.gov (United States)

    2010-10-01

    ... and shall: (1) State in what manner it is claimed the Board or any Board employee has failed or... statement of disagreement has been filed shall clearly note the portion which is disputed and include a copy...

  11. Chairman's report on the INDC for 1974-76

    International Nuclear Information System (INIS)

    Gemmell, G.

    1977-06-01

    A brief report is given of the activities of the International Nuclear Data Committee during 1974-1976. Comments on the meeting in Sydney in October 1974 and in Vienna in October 1975 are included. Suggestions for the future role of the INDC and of the IAEA in the role of nuclear data compilation and evaluation are made

  12. Molecular cloning and expression analysis of three omega-6 desaturase genes from purslane (Portulaca oleracea L.).

    Science.gov (United States)

    Teixeira, M C; Coelho, N; Olsson, M E; Brodelius, P E; Carvalho, I S; Brodelius, M

    2009-07-01

    Two full-length cDNA clones of PoleFAD2 and one full-length cDNA clone of PoleFAD6, encoding omega-6 fatty acid desaturases, the key enzymes for the conversion of oleic into linoleic acid, were isolated from purslane (Portulaca oleracea L.) leaves and seeds. The deduced amino acid sequence of both isoforms of PoleFAD2 showed higher similarities to other microsomal omega-6 desaturases then to PoleFAD6 or other plastidial orthologues, and vice versa. Expression analysis by RT-PCR showed that all genes are expressed in all tissues of purslane tested, but higher levels of mRNA accumulation were detected in reproductive organs and cells that proliferate rapidly or store lipids. Wounding affected the levels of mRNA accumulation of both, FAD2 and FAD6 genes in purslane leaves, while chilling stress affected only FAD2 transcript level. The expression patterns observed reflect the discrete roles of these genes in membrane synthesis for cell division, thylakoid development, and lipid storage or in the biosynthetic pathway for the production of signaling molecules that influence plant development or defense.

  13. The expressions of emotions

    DEFF Research Database (Denmark)

    Vishnivetz, Berta

    Abstract On the broadness of the vast field called “Expressions of Emotions” this study focuses on the whole bodily emotional expression. The main question posed is: Whether there are movement patterns specific to each emotion?. I carried out a thorough review of the theories of emotion...... and of expressions of emotions and movement notation that provided the sources for a careful research plan for the empirical process of this study. On this basis I chose to record onto video the four previously choreographed movements that I considered to correspond each of the following emotions: joy, fear, sadness......, anger. The selection of these four emotions demanded previously to clear up the problems the above named survey ensued. When researchers want to describe a certain movement in the field of psychology and non-verbal communication, it may result in disagreements and misunderstandings which sometimes lead...

  14. Freedom of Expression

    Directory of Open Access Journals (Sweden)

    Guilherme Canela

    2007-06-01

    Full Text Available The freedoms of expression and of the press are basic pillars of the western democracies. The contemporary theoretical framework which gives support to these rights was generated in the wake of the liberal revolutions which took place in Western Europe and in North America starting from the second half of the 1600s. Our purpose in this text is to present the current scene regarding this topic, focusing whenever pertinent on the Brazilian case, and seeking to question the unconditional defense of the freedoms of expression and of the press made by the thinkers who founded these principles vis-á-vis contemporary issues of the communicational universe. Going beyond theoretical-conceptual refl ections, we present and analyze the results of a content analysis showing how 53 Brazilian newspapers and 4 magazines with nationwide circulation report (or not topics relating to freedom of expression and of the press.

  15. Regular expression containment

    DEFF Research Database (Denmark)

    Henglein, Fritz; Nielsen, Lasse

    2011-01-01

    We present a new sound and complete axiomatization of regular expression containment. It consists of the conventional axiomatiza- tion of concatenation, alternation, empty set and (the singleton set containing) the empty string as an idempotent semiring, the fixed- point rule E* = 1 + E × E......* for Kleene-star, and a general coin- duction rule as the only additional rule. Our axiomatization gives rise to a natural computational inter- pretation of regular expressions as simple types that represent parse trees, and of containment proofs as coercions. This gives the axiom- atization a Curry......-Howard-style constructive interpretation: Con- tainment proofs do not only certify a language-theoretic contain- ment, but, under our computational interpretation, constructively transform a membership proof of a string in one regular expres- sion into a membership proof of the same string in another regular expression. We...

  16. In Silico Expression Analysis.

    Science.gov (United States)

    Bolívar, Julio; Hehl, Reinhard; Bülow, Lorenz

    2016-01-01

    Information on the specificity of cis-sequences enables the design of functional synthetic plant promoters that are responsive to specific stresses. Potential cis-sequences may be experimentally tested, however, correlation of genomic sequence with gene expression data enables an in silico expression analysis approach to bioinformatically assess the stress specificity of candidate cis-sequences prior to experimental verification. The present chapter demonstrates an example for the in silico validation of a potential cis-regulatory sequence responsive to cold stress. The described online tool can be applied for the bioinformatic assessment of cis-sequences responsive to most abiotic and biotic stresses of plants. Furthermore, a method is presented based on a reverted in silico expression analysis approach that predicts highly specific potentially functional cis-regulatory elements for a given stress.

  17. Designing Emotionally Expressive Robots

    DEFF Research Database (Denmark)

    Tsiourti, Christiana; Weiss, Astrid; Wac, Katarzyna

    2017-01-01

    Socially assistive agents, be it virtual avatars or robots, need to engage in social interactions with humans and express their internal emotional states, goals, and desires. In this work, we conducted a comparative study to investigate how humans perceive emotional cues expressed by humanoid...... robots through five communication modalities (face, head, body, voice, locomotion) and examined whether the degree of a robot's human-like embodiment affects this perception. In an online survey, we asked people to identify emotions communicated by Pepper -a highly human-like robot and Hobbit – a robot...... for robots....

  18. Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells.

    Science.gov (United States)

    Kajiume, Teruyuki; Ohno, Norioki; Sera, Yasuhiko; Kawahara, Yumi; Yuge, Louis; Kobayashi, Masao

    2009-07-01

    The Polycomb-group (PcG) genes regulate global gene expression in many biological processes, including hematopoiesis, by manipulating specific target genes. It is known that various PcG genes regulate self-renewal of hematopoietic stem cells (HSCs). Here we have shown that the reciprocal expression of PcG proteins regulates self-renewal and differentiation of HSCs. We used murine and human bone marrow cells and evaluated the reciprocal expression of PcG proteins on the basis of their respective intranuclear distributions. PcG-gene expression in HSCs was knocked down by small interfering RNAs. The function of each gene in HSCs was analyzed in vitro and in vivo. Cells were either Bmi1-positive or Mel-18-positive. The Bmi1-positive cells contained very little amounts of Mel-18 and vice versa. The bmi1-knockdown marrow cells did not show HSC function, while the mel-18-knockdown marrow cells showed increased stem cell function. Results of the analysis on human cells were similar to those observed in case of murine cells. In a clinical investigation, transplantation using sources with a low Bmi1 to Mel-18 ratio was associated with early hematopoietic recovery. Reciprocal expression of Bmi1 and Mel-18 regulated HSC function. Here, we observed that expression of the PcG genes-bmi1 and mel-18-is correlated with self-renewal and differentiation of HSCs. Thus, it was suggested that the balance between Bmi1 and Mel-18 regulates self-renewal of HSCs.

  19. StAR protein and steroidogenic enzyme expressions in the rat Harderian gland.

    Science.gov (United States)

    Falvo, Sara; Chieffi Baccaria, Gabriella; Spaziano, Giuseppe; Rosati, Luigi; Venditti, Massimo; Di Fiore, Maria Maddalena; Santillo, Alessandra

    2018-03-01

    The Harderian gland (HG) of the rat (Rattus norvegicus) secretes copious amounts of lipids, such as cholesterol. Here we report a study of the expressions of the StAR protein and key steroidogenic enzymes in the HG of male and female rats. The objective of the present investigation was to ascertain (a) whether the rat HG is involved in steroid production starting with cholesterol, and (b) whether the pattern of gene and protein expressions together with the enzymatic activities display sexual dimorphism. The results demonstrate, for the first time, the expression of StAR gene and protein, and Cyp11a1, Hsd3b1, Hsd17b3, Srd5a1, Srd5a2 and Cyp19a1 genes in the rat HG. StAR mRNA and protein expressions were much greater in males than in females. Immunohistochemical analysis demonstrated a non-homogeneous StAR distribution among glandular cells. Hsd17b3 and Cyp19a1 mRNA levels were higher in males than in females, whereas Srd5a1 mRNA levels were higher in females than in males. No significant differences were observed in mRNA levels of Cyp11a1, Hsd3b1 and Srd5a2 between sexes. Furthermore, the in vitro experiments demonstrated a higher 5α-reductase activity in the female as compared to the male HG vice versa a higher P450 aro activity in males as compared to females. These results suggest that the Harderian gland can be classified as a steroidogenic tissue because it synthesizes cholesterol, expresses StAR and steroidogenic enzymes involved in both androgen and estrogen synthesis. The dimorphic expression and activity of the steroidogenic enzymes may suggest sex-specific hormonal effects into the HG physiology. Copyright © 2018 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved.

  20. Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles

    International Nuclear Information System (INIS)

    Klopfleisch, Robert; Lenze, Dido; Hummel, Michael; Gruber, Achim D

    2010-01-01

    Similar to human breast cancer mammary tumors of the female dog are commonly associated with a fatal outcome due to the development of distant metastases. However, the molecular defects leading to metastasis are largely unknown and the value of canine mammary carcinoma as a model for human breast cancer is unclear. In this study, we analyzed the gene expression signatures associated with mammary tumor metastasis and asked for parallels with the human equivalent. Messenger RNA expression profiles of twenty-seven lymph node metastasis positive or negative canine mammary carcinomas were established by microarray analysis. Differentially expressed genes were functionally characterized and associated with molecular pathways. The findings were also correlated with published data on human breast cancer. Metastatic canine mammary carcinomas had 1,011 significantly differentially expressed genes when compared to non-metastatic carcinomas. Metastatic carcinomas had a significant up-regulation of genes associated with cell cycle regulation, matrix modulation, protein folding and proteasomal degradation whereas cell differentiation genes, growth factor pathway genes and regulators of actin organization were significantly down-regulated. Interestingly, 265 of the 1,011 differentially expressed canine genes are also related to human breast cancer and, vice versa, parts of a human prognostic gene signature were identified in the expression profiles of the metastatic canine tumors. Metastatic canine mammary carcinomas can be discriminated from non-metastatic carcinomas by their gene expression profiles. More than one third of the differentially expressed genes are also described of relevance for human breast cancer. Many of the differentially expressed genes are linked to functions and pathways which appear to be relevant for the induction and maintenance of metastatic progression and may represent new therapeutic targets. Furthermore, dogs are in some aspects suitable as a

  1. Mining frequent binary expressions

    NARCIS (Netherlands)

    Calders, T.; Paredaens, J.; Kambayashi, Y.; Mohania, M.K.; Tjoa, A.M.

    2000-01-01

    In data mining, searching for frequent patterns is a common basic operation. It forms the basis of many interesting decision support processes. In this paper we present a new type of patterns, binary expressions. Based on the properties of a specified binary test, such as reflexivity, transitivity

  2. Facial Expression Recognition

    NARCIS (Netherlands)

    Pantic, Maja; Li, S.; Jain, A.

    2009-01-01

    Facial expression recognition is a process performed by humans or computers, which consists of: 1. Locating faces in the scene (e.g., in an image; this step is also referred to as face detection), 2. Extracting facial features from the detected face region (e.g., detecting the shape of facial

  3. Sensual expressions on faces

    NARCIS (Netherlands)

    Hendriks, A.W.C.J.; Engels, R.C.M.E.; Roek, M.A.E.

    2009-01-01

    We explored the possibility that an emotional facial expression exists specifically for signalling sexual interest. We selected photographs of twenty-eight fashion models (male and female) with large portfolios (range 81 - 1593), choosing only face photographs in which the model was looking into the

  4. Experience and Expression

    Science.gov (United States)

    Hanes, Jay Michael; Weisman, Eleanor

    2016-01-01

    Two artist-educators analyzed their creative process informed by John Dewey's concepts regarding the act of expression. The essay interweaves a description of their performance piece with a discussion of conceptual processes, including intermediality and collaboration as crucial in art making, learning, and pedagogical efficacy. Both the creation…

  5. Facial expressions recognition with an emotion expressive robotic head

    Science.gov (United States)

    Doroftei, I.; Adascalitei, F.; Lefeber, D.; Vanderborght, B.; Doroftei, I. A.

    2016-08-01

    The purpose of this study is to present the preliminary steps in facial expressions recognition with a new version of an expressive social robotic head. So, in a first phase, our main goal was to reach a minimum level of emotional expressiveness in order to obtain nonverbal communication between the robot and human by building six basic facial expressions. To evaluate the facial expressions, the robot was used in some preliminary user studies, among children and adults.

  6. Participants in a medical applications meeting hosted by CERN Head of Medical Applications S. Myers with J. E. Celis, Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research and Prof. JM. Gago, President of Laboratório de Instrumentação e Física Experimental de Partículas (LIP) and Former Minister for Science, Technology and Higher Education of Portugal of the XVII Governo. Were also participating: CERN Life Science Adviser M. Dosanjh with U. Ringborg R. Lewensohn, A. Brahme, R. Moeckli, O. Jäkel and S. Pieck.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    Participants in a medical applications meeting hosted by CERN Head of Medical Applications S. Myers with J. E. Celis, Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research and Prof. JM. Gago, President of Laboratório de Instrumentação e Física Experimental de Partículas (LIP) and Former Minister for Science, Technology and Higher Education of Portugal of the XVII Governo. Were also participating: CERN Life Science Adviser M. Dosanjh with U. Ringborg R. Lewensohn, A. Brahme, R. Moeckli, O. Jäkel and S. Pieck.

  7. 19 January 2011 - British University of Manchester, Vice-President and Dean for the Faculty of Engineering and Physical Sciences Professor of Structural Engineering School of Mechanical, Aerospace and Civil Engineering C. Bailey in CERN Control Centre with Department Head P. Collier; at LHCb with R. Lindner and ATLAS underground experimental area with Deputy Spokesperson D. Charlton, througout accompanied by . Collier with R. Appleby and F. Loebinger

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    19 January 2011 - British University of Manchester, Vice-President and Dean for the Faculty of Engineering and Physical Sciences Professor of Structural Engineering School of Mechanical, Aerospace and Civil Engineering C. Bailey in CERN Control Centre with Department Head P. Collier; at LHCb with R. Lindner and ATLAS underground experimental area with Deputy Spokesperson D. Charlton, througout accompanied by . Collier with R. Appleby and F. Loebinger

  8. Decoding the neural signatures of emotions expressed through sound.

    Science.gov (United States)

    Sachs, Matthew E; Habibi, Assal; Damasio, Antonio; Kaplan, Jonas T

    2018-03-01

    Effective social functioning relies in part on the ability to identify emotions from auditory stimuli and respond appropriately. Previous studies have uncovered brain regions engaged by the affective information conveyed by sound. But some of the acoustical properties of sounds that express certain emotions vary remarkably with the instrument used to produce them, for example the human voice or a violin. Do these brain regions respond in the same way to different emotions regardless of the sound source? To address this question, we had participants (N = 38, 20 females) listen to brief audio excerpts produced by the violin, clarinet, and human voice, each conveying one of three target emotions-happiness, sadness, and fear-while brain activity was measured with fMRI. We used multivoxel pattern analysis to test whether emotion-specific neural responses to the voice could predict emotion-specific neural responses to musical instruments and vice-versa. A whole-brain searchlight analysis revealed that patterns of activity within the primary and secondary auditory cortex, posterior insula, and parietal operculum were predictive of the affective content of sound both within and across instruments. Furthermore, classification accuracy within the anterior insula was correlated with behavioral measures of empathy. The findings suggest that these brain regions carry emotion-specific patterns that generalize across sounds with different acoustical properties. Also, individuals with greater empathic ability have more distinct neural patterns related to perceiving emotions. These results extend previous knowledge regarding how the human brain extracts emotional meaning from auditory stimuli and enables us to understand and connect with others effectively. Copyright © 2018 Elsevier Inc. All rights reserved.

  9. ERG protein expression over time

    DEFF Research Database (Denmark)

    Berg, Kasper Drimer; Brasso, Klaus; Thomsen, Frederik Birkebæk

    2015-01-01

    AIMS: We evaluated the consistency in ERG protein expression from diagnostic specimens through rebiopsies to radical prostatectomies in patients with clinically localised prostate cancer to investigate the validity of ERG status in biopsies. METHODS: ERG expression was assessed by immunohistochem......AIMS: We evaluated the consistency in ERG protein expression from diagnostic specimens through rebiopsies to radical prostatectomies in patients with clinically localised prostate cancer to investigate the validity of ERG status in biopsies. METHODS: ERG expression was assessed...

  10. Matching faces with emotional expressions

    Directory of Open Access Journals (Sweden)

    Wenfeng eChen

    2011-08-01

    Full Text Available There is some evidence that faces with a happy expression are recognized better than faces with other expressions. However, little is known about whether this happy face advantage also applies to perceptual face matching, and whether similar differences exist among other expressions. Using a sequential matching paradigm, we systematically compared the effects of seven basic facial expressions on identity recognition. Identity matching was quickest when a pair of faces had an identical happy/sad/neutral expression, poorer when they had a fearful/surprise/angry expression, and poorest when they had a disgust expression. Faces with a happy/sad/fear/surprise expression were matched faster than those with an anger/disgust expression when the second face in a pair had a neutral expression. These results demonstrate that effects of facial expression on identity recognition are not limited to happy faces when a learned face is immediately tested. The results suggest different influences of expression in perceptual matching and long-term recognition memory.

  11. Act 25/1968 of 20 June amending Sections 9 and 16 of Act 25/1964 of 29 April on nuclear energy

    International Nuclear Information System (INIS)

    1968-01-01

    The main purpose of this Act to amend the 1964 Act on Nuclear Energy is to set the age limit for the Board of the Junta de Energia Nuclear at 70; that of the Director is set at 65. These same provisions also apply to the Chairman and the Director of the Institute for Nuclear Studies. Finally, the Act modifies the composition of the Board of the Junta which henceforth includes only one Vice-Chairman. (NEA) [fr

  12. Egr-1 mediated cardiac miR-99 family expression diverges physiological hypertrophy from pathological hypertrophy.

    Science.gov (United States)

    Ramasamy, Subbiah; Velmurugan, Ganesan; Rekha, Balakrishnan; Anusha, Sivakumar; Shanmugha Rajan, K; Shanmugarajan, Suresh; Ramprasath, Tharmarajan; Gopal, Pandi; Tomar, Dhanendra; Karthik, Karuppusamy V; Verma, Suresh Kumar; Garikipati, Venkata Naga Srikanth; Sudarsan, Rajan

    2018-04-01

    The physiological cardiac hypertrophy is an adaptive condition without myocyte cell death, while pathological hypertrophy is a maladaptive condition associated with myocyte cell death. This study explores the miRNome of α-2M-induced physiologically hypertrophied cardiomyocytes and the role of miRNA-99 family during cardiac hypertrophy. Physiological and pathological cardiac hypertrophy was induced in H9c2 cardiomyoblast cell lines using α-2M and isoproterenol respectively. Total RNA isolation and small RNA sequencing were executed for physiological hypertrophy model. The differentially expressed miRNAs and its target mRNAs were validated in animal models. Transcription factor binding sites were predicted in the promoter of specific miRNAs and validated by ChIP-PCR. Subsequently, the selected miRNA was functionally characterized by overexpression and silencing. The effects of silencing of upstream regulator and downstream target gene were studied. Analysis of small RNA reads revealed the differential expression of a large set of miRNAs during hypertrophy, of which miR-99 family was highly downregulated upon α-2M treatment. However, this miR-99 family expression was upregulated during pathological hypertrophy and confirmed in animal models. ChIP-PCR confirms the binding of Egr-1 transcription factor to the miR-99 promoter. Further, silencing of Egr-1 decreased the expression of miR-99. The overexpression or silencing of miR-99 diverges the physiological hypertrophy to pathological hypertrophy and vice versa by regulating Akt-1 pathway. Silencing of Akt-1 replicates the effect of overexpression of miR-99. The results proved Egr-1 mediated regulation of miR-99 family that plays a key role in determining the fate of cardiac hypertrophy by regulating Akt-1 signaling. Copyright © 2018 Elsevier Inc. All rights reserved.

  13. Expressing emotions in blogs

    DEFF Research Database (Denmark)

    Rodriguez-Hidalgo, Carmina Rodriguez-Hidalgo; Tan, Ed S.; Verlegh, Peeter

    2017-01-01

    Textual paralanguage cues (TPC) have been signaled as effective emotion transmitters online. Though several studies have investigated their properties and occurrence, there remains a gap concerning their communicative impact within specific psychological processes, such as the social sharing...... of emotion (SSE, Rimé, 2009). This study content-analyzed Live Journal blogposts for the occurrence of TPC in three phases of online SSE: initiation, feedback and repost. We compared these to TPC on a second type of emotional expression, emotional venting. Based on Social Information processing theory (SIP......, Walther, 1992), and on the Emotional Mimicry in Context (EMC, Hess & Fischer, 2013) framework, we study predictive relationships in TPC usage in our phased model of online SSE. Results showed that TPC prevailed in SSE blogposts and strongly dominated in emotional venting posts. TPC was more common...

  14. Natural Art, False Expressions

    Directory of Open Access Journals (Sweden)

    Oscar Hernando Nossa García

    2011-05-01

    Full Text Available In the documentary My Kid Could Paint That, directed by Bar-Lev, which deals with Marla Olmstead, the child prodigy of painting, several interviews with persons in the art world are conducted, among them an artist who uses a magnifying glass and the thinnest brushes to do his work. This man, although happy for the success of the child’s abstract paintings, saw in the whole spectacle a mockery of art, and stood firmly by her work. The girl’s father, also an artist, was accused of plagiarism. Cameras entered the child’s studio in order to prove that Marla was the real artist. Why should such relevance be given to authorship? What is the cause of the dispute between the expressive and the rational?

  15. The Expressive Organization

    DEFF Research Database (Denmark)

    This text challenges beliefs about organizational identity, reputation, and branding. It contains a wealth of new ideas for finding the elusive answers to questions troubling contemporary organizations. How does an organization create a strong reputation? What are the implications of corporate br...... students of management, business strategy, accounting, marketing, and communication studies; MBA students; Managers and consultants.......This text challenges beliefs about organizational identity, reputation, and branding. It contains a wealth of new ideas for finding the elusive answers to questions troubling contemporary organizations. How does an organization create a strong reputation? What are the implications of corporate...... branding on organizational structures and processes? How do organizations discover their identities? These are some of the vexing problems addressed in this book by a diverse international team of contributors. According to the authors, the future lies with "the expressive organization". Such organizations...

  16. Global expression differences and tissue specific expression differences in rice evolution result in two contrasting types of differentially expressed genes

    KAUST Repository

    Horiuchi, Youko; Harushima, Yoshiaki; Fujisawa, Hironori; Mochizuki, Takako; Fujita, Masahiro; Ohyanagi, Hajime; Kurata, Nori

    2015-01-01

    Since the development of transcriptome analysis systems, many expression evolution studies characterized evolutionary forces acting on gene expression, without explicit discrimination between global expression differences and tissue

  17. Identification of differentially expressed genes associated with changes in the morphology of Pichia fermentans on apple and peach fruit.

    Science.gov (United States)

    Fiori, Stefano; Scherm, Barbara; Liu, Jia; Farrell, Robert; Mannazzu, Ilaria; Budroni, Marilena; Maserti, Bianca E; Wisniewski, Michael E; Migheli, Quirico

    2012-11-01

    Pichia fermentans (strain DISAABA 726) is an effective biocontrol agent against Monilinia fructicola and Botrytis cinerea when inoculated in artificially wounded apple fruit but is an aggressive pathogen when inoculated on wounded peach fruit, causing severe fruit decay. Pichia fermentans grows as budding yeast on apple tissue and exhibits pseudohyphal growth on peach tissue, suggesting that dimorphism may be associated with pathogenicity. Two complementary suppressive subtractive hybridization (SSH) strategies, that is, rapid subtraction hybridization (RaSH) and PCR-based subtraction, were performed to identify genes differentially expressed by P. fermentans after 24-h growth on apple vs. peach fruit. Gene products that were more highly expressed on peach than on apple tissue, or vice versa, were sequenced and compared with available yeast genome sequence databases. Several of the genes more highly expressed, when P. fermentans was grown on peach, were related to stress response, glycolysis, amino acid metabolism, and alcoholic fermentation but surprisingly not to cell wall degrading enzymes such as pectinases or cellulases. The dual activity of P. fermentans as both a biocontrol agent and a pathogen emphasizes the need for a thorough risk analysis of potential antagonists to avoid unpredictable results that could negatively impact the safe use of postharvest biocontrol strategies. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

  18. Facial Expressivity at 4 Months: A Context by Expression Analysis.

    Science.gov (United States)

    Bennett, David S; Bendersky, Margaret; Lewis, Michael

    2002-01-01

    The specificity predicted by differential emotions theory (DET) for early facial expressions in response to 5 different eliciting situations was studied in a sample of 4-month-old infants (n = 150). Infants were videotaped during tickle, sour taste, jack-in-the-box, arm restraint, and masked-stranger situations and their expressions were coded second by second. Infants showed a variety of facial expressions in each situation; however, more infants exhibited positive (joy and surprise) than negative expressions (anger, disgust, fear, and sadness) across all situations except sour taste. Consistent with DET-predicted specificity, joy expressions were the most common in response to tickling, and were less common in response to other situations. Surprise expressions were the most common in response to the jack-in-the-box, as predicted, but also were the most common in response to the arm restraint and masked-stranger situations, indicating a lack of specificity. No evidence of predicted specificity was found for anger, disgust, fear, and sadness expressions. Evidence of individual differences in expressivity within situations, as well as stability in the pattern across situations, underscores the need to examine both child and contextual factors in studying emotional development. The results provide little support for the DET postulate of situational specificity and suggest that a synthesis of differential emotions and dynamic systems theories of emotional expression should be considered.

  19. What emotion does the "facial expression of disgust" express?

    Science.gov (United States)

    Pochedly, Joseph T; Widen, Sherri C; Russell, James A

    2012-12-01

    The emotion attributed to the prototypical "facial expression of disgust" (a nose scrunch) depended on what facial expressions preceded it. In two studies, the majority of 120 children (5-14 years) and 135 adults (16-58 years) judged the nose scrunch as expressing disgust when the preceding set included an anger scowl, but as angry when the anger scowl was omitted. An even greater proportion of observers judged the nose scrunch as angry when the preceding set also included a facial expression of someone about to be sick. The emotion attributed to the nose scrunch therefore varies with experimental context. PsycINFO Database Record (c) 2012 APA, all rights reserved.

  20. FOOD AND VICES IN SOUTH-EASTERN NIGERIA: IMPLICATIONS ...

    African Journals Online (AJOL)

    procrastination and laziness on the part of individuals; fatalism (the belief that fate determines the status of every human being); poor implementation of government's policies on rural development, lack of assistance to willing Small and Medium Scale Entrepreneurs and farmers; high cost of goods and services in the market ...

  1. Why cognitive science needs philosophy and vice versa.

    Science.gov (United States)

    Thagard, Paul

    2009-04-01

    Contrary to common views that philosophy is extraneous to cognitive science, this paper argues that philosophy has a crucial role to play in cognitive science with respect to generality and normativity. General questions include the nature of theories and explanations, the role of computer simulation in cognitive theorizing, and the relations among the different fields of cognitive science. Normative questions include whether human thinking should be Bayesian, whether decision making should maximize expected utility, and how norms should be established. These kinds of general and normative questions make philosophical reflection an important part of progress in cognitive science. Philosophy operates best, however, not with a priori reasoning or conceptual analysis, but rather with empirically informed reflection on a wide range of findings in cognitive science. Copyright © 2009 Cognitive Science Society, Inc.

  2. Former health care vice minister sentenced / Rokas M. Tracevskis

    Index Scriptorium Estoniae

    Tracevskis, Rokas M.

    2010-01-01

    Leedu endise tervishoiu aseministri Arturas Skikase kohtuotsusest seoses altkäemaksu võtmisega. Arturas Skikas tunnistas üles, et soovis saada verekeskuse direktori käest 5800 eurot. Tervishoiuminister Algis Caplikas jääb ametisse

  3. From iron(III) precursor to magnetite and vice versa

    International Nuclear Information System (INIS)

    Gotic, M.; Jurkin, T.; Music, S.

    2009-01-01

    The syntheses of nanosize magnetite particles by wet-chemical oxidation of Fe 2+ have been extensively investigated. In the present investigation the nanosize magnetite particles were synthesised without using the Fe(II) precursor. This was achieved by γ-irradiation of water-in-oil microemulsion containing only the Fe(III) precursor. The corresponding phase transformations were monitored. Microemulsions (pH ∼ 12.5) were γ-irradiated at a relatively high dose rate of ∼22 kGy/h. Upon 1 h of γ-irradiation the XRD pattern of the precipitate showed goethite and unidentified low-intensity peaks. Upon 6 h of γ-irradiation, reductive conditions were achieved and substoichiometric magnetite (∼Fe 2.71 O 4 ) particles with insignificant amount of goethite particles found in the precipitate. Hydrated electrons (e aq - ), organic radicals and hydrogen gas as radiolytic products were responsible for the reductive dissolution of iron oxide in the microemulsion and the reduction Fe 3+ → Fe 2+ . Upon 18 h of γ-irradiation the precipitate exhibited dual behaviour, it was a more oxidised product than the precipitate obtained after 6 h of γ-irradiation, but it contained magnetite particles in a more reduced form (∼Fe 2.93 O 4 ). It was presumed that the reduction and oxidation processes existed as concurrent competitive processes in the microemulsion. After 18 h of γ-irradiation the pH of the medium shifted from the alkaline to the acidic range. The high dose rate of ∼22 kGy/h was directly responsible for this shift to the acidic range. At a slightly acidic pH a further reduction of Fe 3+ → Fe 2+ resulted in the formation of more stoichiometric magnetite particles, whereas the oxidation conditions in the acidic medium permitted the oxidation Fe 2+ → Fe 3+ . The Fe 3+ was much less soluble in the acidic medium and it hydrolysed and recrystallised as goethite. The γ-irradiation of the microemulsion for 25 h at a lower dose rate of 16 kGy/h produced pure substoichiometric nanosize magnetite particles of about 25 nm in size and with the stoichiometry of Fe 2.83 O 4 .

  4. Passive margins getting squeezed in the mantle convection vice

    Science.gov (United States)

    Yamato, Philippe; Husson, Laurent; Becker, Thorsten W.; Pedoja, Kevin

    2014-05-01

    Passive margins often exhibit uplift, exhumation and tectonic inversion. We speculate that the compression in the lithosphere gradually increased during the Cenozoic. In the same time, the many mountain belts at active margins that accompany this event seem readily witness this increase. However, how that compression increase affects passive margins remains unclear. In order to address this issue, we design a 2D viscous numerical model wherein a lithospheric plate rests above a weaker mantle. It is driven by a mantle conveyor belt, alternatively excited by a lateral downwelling on one side, an upwelling on the other side, or both simultaneously. The lateral edges of the plate are either free or fixed, representing the cases of free convergence, and collision or slab anchoring, respectively. This distinction changes the upper boundary condition for mantle circulation and, as a consequence, the stress field. Our results show that between these two regimes, the flow pattern transiently evolves from a free-slip convection mode towards a no-slip boundary condition above the upper mantle. In the second case, the lithosphere is highly stressed horizontally and deforms. For an equivalent bulk driving force, compression increases drastically at passive margins provided that upwellings are active. Conversely, if downwellings alone are activated, compression occurs at short distances from the trench and extension prevails elsewhere. These results are supported by Earth-like 3D spherical models that reveal the same pattern, where active upwellings are required to excite passive margins compression. These results support the idea that compression at passive margins, is the response to the underlying mantle flow, that is increasingly resisted by the Cenozoic collisions.

  5. Energetic Particles: From Sun to Heliosphere - and vice versa

    Science.gov (United States)

    Wimmer-Schweingruber, R. F.; Rodriguez-Pacheco, J.; Boden, S.; Boettcher, S. I.; Cernuda, I.; Dresing, N.; Drews, C.; Droege, W.; Espinosa Lara, F.; Gomez-Herrero, R.; Heber, B.; Ho, G. C.; Klassen, A.; Kulkarni, S. R.; Mann, G. J.; Martin-Garcia, C.; Mason, G. M.; Panitzsch, L.; Prieto, M.; Sanchez, S.; Terasa, C.; Eldrum, S.

    2017-12-01

    Energetic particles in the heliosphere can be measured at their elevated energetic status after three processes: injection, acceleration, and transport. Suprathermal seed particles have speeds well above the fast magnetosonic speed in the solar wind frame of reference and can vary from location to location and within the solar activity cycle. Acceleration sites include reconnecting current sheets in solar flares or magnetspheric boundaries, shocks in the solar corona, heliosphere and a planetary obstacles, as well as planetary magnetospheres. Once accelerated, particles are transported from the acceleration site into and through the heliosphere. Thus, by investigating properties of energetic particles such as their composition, energy spectra, pitch-angle distribution, etc. one can attempt to distinguish their origin or injection and acceleration site. This in turn allows us to better understand transport effects whose underlying microphysics is also a key ingredient in the acceleration of particles. In this presentation we will present some clear examples which link energetic particles from their observing site to their source locations. These include Jupiter electrons, singly-charged He ions from CIRs, and 3He from solar flares. We will compare these examples with the measurement capabilities of the Energetic Particle Detector (EPD) on Solar Orbiter and consider implications for the key science goal of Solar Orbiter and Solar Proble Plus - How the Sun creates and controls the heliosphere.

  6. From substance use to homelessness or vice versa?

    Science.gov (United States)

    McVicar, Duncan; Moschion, Julie; van Ours, Jan C

    2015-07-01

    Homelessness is associated with substance use, but whether substance use precedes or follows homelessness is unclear. We investigate the nature of the relationship between homelessness and substance use using data from the unique Australian panel dataset Journeys Home collected in 4 surveys over the period from October 2011 to May 2013. Our data refer to 1325 individuals who were homeless or at risk of becoming homeless. We investigate dynamics in homelessness and substance use over the survey period. We find that the two are closely related: homeless individuals are more likely to be substance users and substance users are more likely to be homeless. These relationships, however, are predominantly driven by observed and unobserved individual characteristics which cause individuals to be both more likely to be homeless and to be substance users. Once we take these personal characteristics into account it seems that homelessness does not affect substance use, although we cannot rule out that alcohol use increases the probability that an individual becomes homeless. These overall relationships also hide some interesting heterogeneity by 'type' of homelessness. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. 2017-2018 Travel Expense Reports for Chandra Madramootoo, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Chantal Taylor

    07-11. Destination(s):. Kenya, Uganda and Tanzania. Airfare: $4,788.97. Other. Transportation: $147.43. Accommodation: $2,058.50. Meals and. Incidentals: $701.92. Other: $399.15. Total: $8,095.97. Comments: From residence in Montreal, ...

  8. 2016-2017 Travel Expense Report for Joanne Charette, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Beata Bialic

    04-12. Destination(s):. Miami, USA. Airfare: $503.09. Other. Transportation: $76.14. Accommodation: $673.75. Meals and. Incidentals: $435.36. Other: $0.00. Total: $1,688.34. Comments: 2016-2017 Travel Expense Report for Joanne. Charette ...

  9. 2017-2018 Travel Expense Reports for Sylvain Dufour, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Chantal Taylor

    09-30 to 2017-10-06. Destination(s):. Orlando, FL (USA). Airfare: $751.97. Other. Transportation: $228.39. Accommodation: $1,102.96. Meals and. Incidentals: $1,342.07. Other: $7.51. Total: $3,432.90. Comments: 2017-2018 Travel Expense ...

  10. 2017-2018 Travel Expense Reports for Joanne Charette, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    BB

    Purpose: Attend the World Strategic Forum. Date(s):. 2017-04-18 to 2017-04-20. Destination(s):. Miami, USA. Airfare: $399.92. Other. Transportation: $101.41. Accommodation: $0.00. Meals and. Incidentals: $466.55. Other: $0.00. Total: $967.88. Comments: 2017-2018 Travel Expense Reports for Joanne. Charette ...

  11. 2016-2017 Travel Expense Report for Joanne Charette, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Beata Bialic

    s):. 2016-06-12 to 2016-06-15. Destination(s):. Montreal. Airfare: $0.00. Other. Transportation: $252.70. Accommodation: $924.63. Meals and. Incidentals: $144.56. Other: $0.00. Total: $1,321.89. Comments: 2016-2017 Travel Expense Report ...

  12. 2017-2018 Travel Expense Reports for Sylvain Dufour, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    SD

    Review of local operations in the Middle East and North Africa Regional. Office. Date(s):. 2017-04-22 to 2017-04-29. Destination(s):. Cairo. Airfare: $6,789.78. Other. Transportation: $105.37. Accommodation: $1,472.82. Meals and. Incidentals: $560.97. Other: $114.20. Total: $9,043.14. Comments: 2017-2018 Travel ...

  13. 2016-2017 Travel Expense Report for Sylvain Dufour, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Beata Bialic

    Purpose: Visit to IDRC's Regional Office in Montevideo. Date(s):. 2016-04-01 to 2016-04-10. Destination(s):. Montevideo. Airfare: $5,886.83. Other. Transportation: $67.50. Accommodation: $952.70. Meals and. Incidentals: $1,163.44. Other: $121.80. Total: $8,192.27. Comments: 2016-2017 Travel Expense Report for ...

  14. 2016-2017 Travel Expense Reports for Chandra Madramootoo, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Beata Bialic

    14 to 2016-08-23. Destination(s):. Peru/Colombia. Airfare: $6,070.40. Other. Transportation: $142.60. Accommodation: $1,512.99. Meals and. Incidentals: $411.51. Other: $0.00. Total: $8,137.50. Comments: 2016-2017 Travel Expense Reports ...

  15. 2017-2018 Travel Expense Reports for Joanne Charette, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Chantal Taylor

    Purpose: Attend staff meetings at the Middle East and North Africa Regional Office. Date(s):. 2017-10-09 to 2017-10-13. Destination(s):. Cairo, Egypt. Airfare: $4,512.88. Other. Transportation: $118.45. Accommodation: $494.52. Meals and. Incidentals: $300.00. Other: $114.20. Total: $5,540.05. Comments: 2017-2018 Travel ...

  16. 2017-2018 Travel Expense Reports for Joanne Charette, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    07-12. Destination(s):. Kenya, Uganda and Tanzania. Airfare: $5,885.73. Other. Transportation: $70.60. Accommodation: $2,983.48. Meals and. Incidentals: $1,053.24. Other: $334.93. Total: $10,327.98. Comments: 2017-2018 Travel Expense ...

  17. 2017-2018 Travel Expense Reports for Joanne Charette, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    BB

    Purpose: Meeting with stakeholders. Date(s):. 2017-05-28 to 2017-06-04. Destination(s):. Guatemala/Honduras. Airfare: $3,069.59. Other. Transportation: $317.65. Accommodation: $2,136.60. Meals and. Incidentals: $532.40. Other: $0.00. Total: $6,056.24. Comments: 2017-2018 Travel Expense Reports for Joanne.

  18. Adapting computational text analysis to social science (and vice versa

    Directory of Open Access Journals (Sweden)

    Paul DiMaggio

    2015-11-01

    Full Text Available Social scientists and computer scientist are divided by small differences in perspective and not by any significant disciplinary divide. In the field of text analysis, several such differences are noted: social scientists often use unsupervised models to explore corpora, whereas many computer scientists employ supervised models to train data; social scientists hold to more conventional causal notions than do most computer scientists, and often favor intense exploitation of existing algorithms, whereas computer scientists focus more on developing new models; and computer scientists tend to trust human judgment more than social scientists do. These differences have implications that potentially can improve the practice of social science.

  19. Text Mining to Support Gene Ontology Curation and Vice Versa.

    Science.gov (United States)

    Ruch, Patrick

    2017-01-01

    In this chapter, we explain how text mining can support the curation of molecular biology databases dealing with protein functions. We also show how curated data can play a disruptive role in the developments of text mining methods. We review a decade of efforts to improve the automatic assignment of Gene Ontology (GO) descriptors, the reference ontology for the characterization of genes and gene products. To illustrate the high potential of this approach, we compare the performances of an automatic text categorizer and show a large improvement of +225 % in both precision and recall on benchmarked data. We argue that automatic text categorization functions can ultimately be embedded into a Question-Answering (QA) system to answer questions related to protein functions. Because GO descriptors can be relatively long and specific, traditional QA systems cannot answer such questions. A new type of QA system, so-called Deep QA which uses machine learning methods trained with curated contents, is thus emerging. Finally, future advances of text mining instruments are directly dependent on the availability of high-quality annotated contents at every curation step. Databases workflows must start recording explicitly all the data they curate and ideally also some of the data they do not curate.

  20. Impact of Cybernetics on Information Science, and Vice Versa.

    Science.gov (United States)

    Heilprin, Laurence B.

    The impact of cybernetics on information science occurs chiefly through the concepts of variety, the law of requisite variety, and theory of transformations. Through these it pervades every aspect of information science. However, other basic sciences such as physics, biology, psychology are in their spheres equally pervasive, and information…

  1. The Role of Neurosciences in Education… and vice versa

    Science.gov (United States)

    Gruart, Agnès

    2014-01-01

    One of the key questions in education is how the learning process in the classroom takes place and how different environmental and individual circumstances (attention, motivation, nutrition, stimulus presentation, etc.) can enhance the child's capabilities to learn and to remember. These and other cognitive skills are shaped as a consequence of…

  2. Vice-Chancellors Influence on Academic Staff Intentions to Use ...

    African Journals Online (AJOL)

    kmacharia

    adoption and diffusion of Learning Management System (LMS) by academic staff for ... of TAM, as a supportive framework for investigating the academic staff ... This definition includes university-wide information systems that embrace blended.

  3. From substance use to homelessness or vice versa?

    NARCIS (Netherlands)

    McVicar, Duncan; Moschion, Julie; van Ours, Jan

    Homelessness is associated with substance use, but whether substance use precedes or follows homelessness is unclear. We investigate the nature of the relationship between homelessness and substance use using data from the unique Australian panel dataset Journeys Home collected in 4 surveys over the

  4. Executive Assistant - Vice-President, Programs and Partnerships ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Executive Assistant also performs a variety of office management related tasks, offers ... Operational and administrative activities of the VP's Office ... PPB staff at Head Quarter and reports any excess leave issues to the attention of the VP.

  5. 2016-2017 Travel Expense Reports for Joanne Charette, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Beata Bialic

    13 to 2016-08-23. Destination(s):. Peru/Colombia. Airfare: $7,475.56. Other. Transportation: $0.00. Accommodation: $2,313.89. Meals and. Incidentals: $742.12. Other: $308.42. Total: $10,839.99. Comments: 2016-2017 Travel Expense Reports ...

  6. 2016-2017 Travel Expense Reports for Joanne Charette, Vice ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Beata Bialic

    ):. 2016-11-03. Destination(s):. Montreal. Airfare: $0.00. Other. Transportation: $288.32. Accommodation: $0.00. Meals and. Incidentals: $45.60. Other: $0.00. Total: $333.92. Comments: 2016-2017 Travel Expense Reports for Joanne. Charette ...

  7. Generational Differences of Emotional Expression

    Institute of Scientific and Technical Information of China (English)

    李学勇

    2014-01-01

    As a kind of subjective psychological activity, emotion can only be known and perceived by a certain expressive form. Varies as the different main bodies, difference of emotional expression can be reflected not only among individuals but between generations. The old conceals their emotions inside, the young express their emotions boldly, and the middle-aged are rational and deep in their expressions. Facing and understanding such differences is the premise and foundation of the con-struction of a harmonious relationship between different generations.

  8. Precise Analysis of String Expressions

    DEFF Research Database (Denmark)

    Christensen, Aske Simon; Møller, Anders; Schwartzbach, Michael Ignatieff

    2003-01-01

    We perform static analysis of Java programs to answer a simple question: which values may occur as results of string expressions? The answers are summarized for each expression by a regular language that is guaranteed to contain all possible values. We present several applications of this analysis...... are automatically produced. We present extensive benchmarks demonstrating that the analysis is efficient and produces results of useful precision......., including statically checking the syntax of dynamically generated expressions, such as SQL queries. Our analysis constructs flow graphs from class files and generates a context-free grammar with a nonterminal for each string expression. The language of this grammar is then widened into a regular language...

  9. Oracle Application Express 4 Recipes

    CERN Document Server

    Zehoo, Edmund

    2011-01-01

    Oracle Application Express 4 Recipes provides an example-based approach to learning Application Express - the ground-breaking, rapid application development platform included with every Oracle Database license. The recipes format is ideal for the quick-study who just wants a good example or two to kick start their thinking and get pointed in the right direction. The recipes cover the gamut of Application Express development. Author and Application Express expert Edmund Zehoo shows how to create data entry screens, visualize data in the form of reports and charts, implement validation and back-

  10. Expression modeling for expression-invariant face recognition

    NARCIS (Netherlands)

    Haar, F.B. Ter; Veltkamp, R.C.

    2010-01-01

    Morphable face models have proven to be an effective tool for 3D face modeling and face recognition, but the extension to 3D face scans with expressions is still a challenge. The two main difficulties are (1) how to build a new morphable face model that deals with expressions, and (2) how to fit

  11. Human papillomavirus gene expression

    International Nuclear Information System (INIS)

    Chow, L.T.; Hirochika, H.; Nasseri, M.; Stoler, M.H.; Wolinsky, S.M.; Chin, M.T.; Hirochika, R.; Arvan, D.S.; Broker, T.R.

    1987-01-01

    To determine the role of tissue differentiation on expression of each of the papillomavirus mRNA species identified by electron microscopy, the authors prepared exon-specific RNA probes that could distinguish the alternatively spliced mRNA species. Radioactively labeled single-stranded RNA probes were generated from a dual promoter vector system and individually hybridized to adjacent serial sections of formalin-fixed, paraffin-embedded biopsies of condylomata. Autoradiography showed that each of the message species had a characteristic tissue distribution and relative abundance. The authors have characterized a portion of the regulatory network of the HPVs by showing that the E2 ORF encodes a trans-acting enhancer-stimulating protein, as it does in BPV-1 (Spalholz et al. 1985). The HPV-11 enhancer was mapped to a 150-bp tract near the 3' end of the URR. Portions of this region are duplicated in some aggressive strains of HPV-6 (Boshart and zur Hausen 1986; Rando et al. 1986). To test the possible biological relevance of these duplications, they cloned tandem arrays of the enhancer and demonstrated, using a chloramphenicol acetyltransferase (CAT) assay, that they led to dramatically increased transcription proportional to copy number. Using the CAT assays, the authors found that the E2 proteins of several papillomavirus types can cross-stimulate the enhancers of most other types. This suggests that prior infection of a tissue with one papillomavirus type may provide a helper effect for superinfection and might account fo the HPV-6/HPV-16 coinfections in condylomata that they have observed

  12. Differential Gene Expression and Aging

    Directory of Open Access Journals (Sweden)

    Laurent Seroude

    2002-01-01

    Full Text Available It has been established that an intricate program of gene expression controls progression through the different stages in development. The equally complex biological phenomenon known as aging is genetically determined and environmentally modulated. This review focuses on the genetic component of aging, with a special emphasis on differential gene expression. At least two genetic pathways regulating organism longevity act by modifying gene expression. Many genes are also subjected to age-dependent transcriptional regulation. Some age-related gene expression changes are prevented by caloric restriction, the most robust intervention that slows down the aging process. Manipulating the expression of some age-regulated genes can extend an organism's life span. Remarkably, the activity of many transcription regulatory elements is linked to physiological age as opposed to chronological age, indicating that orderly and tightly controlled regulatory pathways are active during aging.

  13. Measuring facial expression of emotion.

    Science.gov (United States)

    Wolf, Karsten

    2015-12-01

    Research into emotions has increased in recent decades, especially on the subject of recognition of emotions. However, studies of the facial expressions of emotion were compromised by technical problems with visible video analysis and electromyography in experimental settings. These have only recently been overcome. There have been new developments in the field of automated computerized facial recognition; allowing real-time identification of facial expression in social environments. This review addresses three approaches to measuring facial expression of emotion and describes their specific contributions to understanding emotion in the healthy population and in persons with mental illness. Despite recent progress, studies on human emotions have been hindered by the lack of consensus on an emotion theory suited to examining the dynamic aspects of emotion and its expression. Studying expression of emotion in patients with mental health conditions for diagnostic and therapeutic purposes will profit from theoretical and methodological progress.

  14. Homeobox gene expression in Brachiopoda

    DEFF Research Database (Denmark)

    Altenburger, Andreas; Martinez, Pedro; Wanninger, Andreas

    2011-01-01

    (ectoderm) specification with co-opted functions in notochord formation in chordates and left/right determination in ambulacrarians and vertebrates. The caudal ortholog, TtrCdx, is first expressed in the ectoderm of the gastrulating embryo in the posterior region of the blastopore. Its expression stays......The molecular control that underlies brachiopod ontogeny is largely unknown. In order to contribute to this issue we analyzed the expression pattern of two homeobox containing genes, Not and Cdx, during development of the rhynchonelliform (i.e., articulate) brachiopod Terebratalia transversa...... completion of larval development, which is marked by a three-lobed body with larval setae. Expression starts at gastrulation in two areas lateral to the blastopore and subsequently extends over the animal pole of the gastrula. With elongation of the gastrula, expression at the animal pole narrows to a small...

  15. Nestin expression in neuroepithelial tumors.

    Science.gov (United States)

    Schiffer, Davide; Manazza, Andrea; Tamagno, Ilaria

    2006-05-29

    Nestin is a marker of early stages of neurocytogenesis. It has been studied in 50 neuroepithelial tumors, mostly gliomas of different malignancy grades, by immunohistochemistry, immunofluorescence, immunoblotting, and confocal microscopy and compared with GFAP and Vimentin. As an early marker of differentiation, Nestin is almost not expressed in diffuse astrocytomas, variably expressed in anaplastic astrocytomas and strongly and irregularly expressed in glioblastomas. Negative in oligodendrogliomas, it stains ependymomas and shows a gradient of expression in pilocytic astrocytomas. In glioblastomas, Nestin distribution does not completely correspond to that of GFAP and Vimentin with which its expression varies in tumor cells in a complementary way, as confirmed by confocal microscopy. Tumor cells can thus either derive from or differentiate toward the neurocytogenetic stages. Hypothetically, they could be put in relation with radial glia where during embriogenesis the three antigens are successively expressed. Completely negative cells of invasive or recurrent glioblastomas may represent malignant selected clones after accumulation of mutations or early stem cells not expressing antigens.

  16. The expressive stance: intentionality, expression, and machine art

    OpenAIRE

    Linson, Adam

    2013-01-01

    This paper proposes a new interpretive stance for interpreting artistic works and performances that is relevant to artificial intelligence research but also has broader implications. Termed the expressive stance, this stance makes intelligible a critical distinction between present-day machine art and human art, but allows for the possibility that future machine art could find a place alongside our own. The expressive stance is elaborated as a response to Daniel Dennett's notion of the intent...

  17. [Prosopagnosia and facial expression recognition].

    Science.gov (United States)

    Koyama, Shinichi

    2014-04-01

    This paper reviews clinical neuropsychological studies that have indicated that the recognition of a person's identity and the recognition of facial expressions are processed by different cortical and subcortical areas of the brain. The fusiform gyrus, especially the right fusiform gyrus, plays an important role in the recognition of identity. The superior temporal sulcus, amygdala, and medial frontal cortex play important roles in facial-expression recognition. Both facial recognition and facial-expression recognition are highly intellectual processes that involve several regions of the brain.

  18. Expression in E. coli systems

    DEFF Research Database (Denmark)

    Krogsdam, Anne-M; Kristiansen, Karsten; Nøhr, Jane

    2003-01-01

    intracellularly in soluble form. In E. coli, proteins containing disulfide bonds are best produced by secretion because the disulfide forming foldases reside in the periplasm. Likewise, a correct N-terminus is more likely to be obtained upon secretion. Moreover, potentially toxic proteins are more likely......Owing to cost advantage, speed of production, and often high product yield (up to 50% of total cell protein), expression in Escherichia coli is generally the first choice when attempting to express a recombinant protein. Expression systems exist to produce recombinant protein intracellularly...

  19. False memory for idiomatic expressions in younger and older adults: evidence for indirect activation of figurative meanings.

    Science.gov (United States)

    Coane, Jennifer H; Sánchez-Gutiérrez, Claudia; Stillman, Chelsea M; Corriveau, Jennifer A

    2014-01-01

    Idiomatic expressions can be interpreted literally or figuratively. These two meanings are often processed in parallel or very rapidly, as evidenced by online measures of idiomatic processing. Because in many cases the figurative meaning cannot be derived from the component lexical elements and because of the speed with which this meaning is accessed, it is assumed such meanings are stored in semantic memory. In the present study, we examined how literal equivalents and intact idiomatic expressions are stored in memory and whether episodic memory traces interact or interfere with semantic-level representations and vice versa. To examine age-invariance, younger and older adults studied lists of idioms and literal equivalents. On a recognition test, some studied items were presented in the alternative form (e.g., if the idiom was studied, its literal equivalent was tested). False alarms to these critical items suggested that studying literal equivalents activates the idiom from which they are derived, presumably due to spreading activation in lexical/semantic networks, and results in high rates of errors. Importantly, however, the converse (false alarms to literal equivalents after studying the idiom) were significantly lower, suggesting an advantage in storage for idioms. The results are consistent with idiom processing models that suggest obligatory access to figurative meanings and that this access can also occur indirectly, through literal equivalents.

  20. False memory for idiomatic expressions in younger and older adults: Evidence for indirect activation of figurative meanings

    Directory of Open Access Journals (Sweden)

    Jennifer H Coane

    2014-07-01

    Full Text Available Idiomatic expressions can be interpreted literally or figuratively. These two meanings are often processed in parallel or very rapidly, as evidenced by online measures of idiomatic processing. Because in many cases the figurative meaning cannot be derived from the component lexical elements and because of the speed with which this meaning is accessed, it is assumed such meanings are stored in semantic memory. In the present study, we examined how literal equivalents and intact idiomatic expressions are stored in memory and whether episodic memory traces interact or interfere with semantic-level representations and vice versa. To examine age-invariance, younger and older adults studied lists of idioms and literal equivalents. On a recognition test, some studied items were presented in the alternative form (e.g., if the idiom was studied, its literal equivalent was tested. False alarms to these critical items suggested that studying literal equivalents activates the idiom from which they are derived, presumably due to spreading activation in lexical/semantic networks, and results in high rates of errors. Importantly, however, the converse (false alarms to literal equivalents after studying the idiom were significantly lower, suggesting an advantage in storage for idioms. The results are consistent with idiom processing models that suggest obligatory access to figurative meanings and that this access can also occur indirectly, through literal equivalents.

  1. Analysis of Facial Expression by Taste Stimulation

    Science.gov (United States)

    Tobitani, Kensuke; Kato, Kunihito; Yamamoto, Kazuhiko

    In this study, we focused on the basic taste stimulation for the analysis of real facial expressions. We considered that the expressions caused by taste stimulation were unaffected by individuality or emotion, that is, such expressions were involuntary. We analyzed the movement of facial muscles by taste stimulation and compared real expressions with artificial expressions. From the result, we identified an obvious difference between real and artificial expressions. Thus, our method would be a new approach for facial expression recognition.

  2. A Tattoo Is Expression, Too.

    Science.gov (United States)

    Dowling-Sendor, Benjamin

    1997-01-01

    In "Stephenson v. Davenport Community School District," the U.S. Eighth Circuit Court of Appeals ruled that schools cannot adopt unduly vague policies to regulate student expression, in this case, a cross-shaped tattoo. (LMI)

  3. Online handwritten mathematical expression recognition

    Science.gov (United States)

    Büyükbayrak, Hakan; Yanikoglu, Berrin; Erçil, Aytül

    2007-01-01

    We describe a system for recognizing online, handwritten mathematical expressions. The system is designed with a user-interface for writing scientific articles, supporting the recognition of basic mathematical expressions as well as integrals, summations, matrices etc. A feed-forward neural network recognizes symbols which are assumed to be single-stroke and a recursive algorithm parses the expression by combining neural network output and the structure of the expression. Preliminary results show that writer-dependent recognition rates are very high (99.8%) while writer-independent symbol recognition rates are lower (75%). The interface associated with the proposed system integrates the built-in recognition capabilities of the Microsoft's Tablet PC API for recognizing textual input and supports conversion of hand-drawn figures into PNG format. This enables the user to enter text, mathematics and draw figures in a single interface. After recognition, all output is combined into one LATEX code and compiled into a PDF file.

  4. Emerald Express '95: Analysis Report

    National Research Council Canada - National Science Library

    Newett, Sandra

    1996-01-01

    The purpose of Emerald Express was to bring together senior representatives from military, relief, political, and diplomatic communities to address issues that arise during Humanitarian Assistance and Peace Operations (HA/POs...

  5. Race, Reparations, and Free Expression.

    Science.gov (United States)

    Brownstein, Andrew

    2001-01-01

    Describes how a controversial newspaper ad opposing slavery reparations and the subsequent trashing of the student daily have set off a debate at Brown University about the competing values of sensitivity and free expression. (EV)

  6. Expression of Recombinant Human Butyrylcholinesterase

    National Research Council Canada - National Science Library

    Lockridge, Oksana

    1997-01-01

    .... The G117H enzyme has the potential to be useful for decontamination of skin and eye. To determine how many amino acids could be deleted from butyrylcholinesterase without loss of activity, deletion mutants were expressed...

  7. Regulation of eucaryotic gene expression

    Energy Technology Data Exchange (ETDEWEB)

    Brent, R.; Ptashne, M.S

    1989-05-23

    This patent describes a method of regulating the expression of a gene in a eucaryotic cell. The method consists of: providing in the eucaryotic cell, a peptide, derived from or substantially similar to a peptide of a procaryotic cell able to bind to DNA upstream from or within the gene, the amount of the peptide being sufficient to bind to the gene and thereby control expression of the gene.

  8. Craniopharyngioma: Survivin expression and ultrastructure

    Science.gov (United States)

    ZHU, JIANG; YOU, CHAO

    2015-01-01

    The aim of the present study was to investigate the significance of survivin protein expression levels in craniopharyngioma. Tumor samples and clinical data were obtained from 50 patients with craniopharyngioma who were admitted to the West China Hospital of Sichuan University (Chengdu, China). The morphology of the craniopharyngioma samples was observed using optical and electron microscopes, and survivin expression was investigated in the samples by immunohistochemical analysis. The immunohistochemical results revealed survivin expression in all of the craniopharyngioma samples, but not in the healthy brain tissue samples. It was identified that survivin was expressed at a higher level in cases of the adamantinomatous type compared with those of the squamous-papillary type, in male patients compared with female patients, in children compared with adults and in recurrent cases compared with non-recurrent cases. Furthermore, no significant difference was detected in survivin expression levels among the tumors of different subtypes and different disease stages. The results of the present study indicate that survivin is significant in the development of craniopharyngioma, and that survivin protein expression levels are a meaningful indicator for assessing craniopharyngioma recurrence. PMID:25435936

  9. The motivation to express prejudice

    Science.gov (United States)

    Forscher, Patrick S.; Cox, William T. L.; Graetz, Nicholas; Devine, Patricia G.

    2015-01-01

    Contemporary prejudice research focuses primarily on people who are motivated to respond without prejudice and the ways in which unintentional bias can cause these people to act inconsistent with this motivation. However, some real-world phenomena (e.g., hate speech, hate crimes) and experimental findings (e.g., Plant & Devine, 2001; 2009) suggest that some expressions of prejudice are intentional. These phenomena and findings are difficult to explain solely from the motivations to respond without prejudice. We argue that some people are motivated to express prejudice, and we develop the motivation to express prejudice (MP) scale to measure this motivation. In seven studies involving more than 6,000 participants, we demonstrate that, across scale versions targeted at Black people and gay men, the MP scale has good reliability and convergent, discriminant, and predictive validity. In normative climates that prohibit prejudice, the internal and external motivations to express prejudice are functionally non-independent, but they become more independent when normative climates permit more prejudice toward a target group. People high in the motivation to express prejudice are relatively likely to resist pressure to support programs promoting intergroup contact and vote for political candidates who support oppressive policies. The motivation to express prejudice predicted these outcomes even when controlling for attitudes and the motivations to respond without prejudice. This work encourages contemporary prejudice researchers to broaden the range of samples, target groups, and phenomena that they study, and more generally to consider the intentional aspects of negative intergroup behavior. PMID:26479365

  10. YANA – a software tool for analyzing flux modes, gene-expression and enzyme activities

    Directory of Open Access Journals (Sweden)

    Engels Bernd

    2005-06-01

    Full Text Available Abstract Background A number of algorithms for steady state analysis of metabolic networks have been developed over the years. Of these, Elementary Mode Analysis (EMA has proven especially useful. Despite its low user-friendliness, METATOOL as a reliable high-performance implementation of the algorithm has been the instrument of choice up to now. As reported here, the analysis of metabolic networks has been improved by an editor and analyzer of metabolic flux modes. Analysis routines for expression levels and the most central, well connected metabolites and their metabolic connections are of particular interest. Results YANA features a platform-independent, dedicated toolbox for metabolic networks with a graphical user interface to calculate (integrating METATOOL, edit (including support for the SBML format, visualize, centralize, and compare elementary flux modes. Further, YANA calculates expected flux distributions for a given Elementary Mode (EM activity pattern and vice versa. Moreover, a dissection algorithm, a centralization algorithm, and an average diameter routine can be used to simplify and analyze complex networks. Proteomics or gene expression data give a rough indication of some individual enzyme activities, whereas the complete flux distribution in the network is often not known. As such data are noisy, YANA features a fast evolutionary algorithm (EA for the prediction of EM activities with minimum error, including alerts for inconsistent experimental data. We offer the possibility to include further known constraints (e.g. growth constraints in the EA calculation process. The redox metabolism around glutathione reductase serves as an illustration example. All software and documentation are available for download at http://yana.bioapps.biozentrum.uni-wuerzburg.de. Conclusion A graphical toolbox and an editor for METATOOL as well as a series of additional routines for metabolic network analyses constitute a new user

  11. Presence and expression of hydrogenase specific C-terminal endopeptidases in cyanobacteria

    Directory of Open Access Journals (Sweden)

    Lindblad Peter

    2003-05-01

    Full Text Available Abstract Background Hydrogenases catalyze the simplest of all chemical reactions: the reduction of protons to molecular hydrogen or vice versa. Cyanobacteria can express an uptake, a bidirectional or both NiFe-hydrogenases. Maturation of those depends on accessory proteins encoded by hyp-genes. The last maturation step involves the cleavage of a ca. 30 amino acid long peptide from the large subunit by a C-terminal endopeptidase. Until know, nothing is known about the maturation of cyanobacterial NiFe-hydrogenases. The availability of three complete cyanobacterial genome sequences from strains with either only the uptake (Nostoc punctiforme ATCC 29133/PCC 73102, only the bidirectional (Synechocystis PCC 6803 or both NiFe-hydrogenases (Anabaena PCC 7120 prompted us to mine these genomes for hydrogenase maturation related genes. In this communication we focus on the presence and the expression of the NiFe-hydrogenases and the corresponding C-terminal endopeptidases, in the three strains mentioned above. Results We identified genes encoding putative cyanobacterial hydrogenase specific C-terminal endopeptidases in all analyzed cyanobacterial genomes. The genes are not part of any known hydrogenase related gene cluster. The derived amino acid sequences show only low similarity (28–41% to the well-analyzed hydrogenase specific C-terminal endopeptidase HybD from Escherichia coli, the crystal structure of which is known. However, computational secondary and tertiary structure modeling revealed the presence of conserved structural patterns around the highly conserved active site. Gene expression analysis shows that the endopeptidase encoding genes are expressed under both nitrogen-fixing and non-nitrogen-fixing conditions. Conclusion Anabaena PCC 7120 possesses two NiFe-hydrogenases and two hydrogenase specific C-terminal endopeptidases but only one set of hyp-genes. Thus, in contrast to the Hyp-proteins, the C-terminal endopeptidases are the only known

  12. Synthesis of Heparan Sulfate with Cyclophilin B-binding Properties Is Determined by Cell Type-specific Expression of Sulfotransferases*

    Science.gov (United States)

    Deligny, Audrey; Denys, Agnès; Marcant, Adeline; Melchior, Aurélie; Mazurier, Joël; van Kuppevelt, Toin H.; Allain, Fabrice

    2010-01-01

    Cyclophilin B (CyPB) induces migration and adhesion of T lymphocytes via a mechanism that requires interaction with 3-O-sulfated heparan sulfate (HS). HS biosynthesis is a complex process with many sulfotransferases involved. N-Deacetylases/N-sulfotransferases are responsible for N-sulfation, which is essential for subsequent modification steps, whereas 3-O-sulfotransferases (3-OSTs) catalyze the least abundant modification. These enzymes are represented by several isoforms, which differ in term of distribution pattern, suggesting their involvement in making tissue-specific HS. To elucidate how the specificity of CyPB binding is determined, we explored the relationships between the expression of these sulfotransferases and the generation of HS motifs with CyPB-binding properties. We demonstrated that high N-sulfate density and the presence of 2-O- and 3-O-sulfates determine binding of CyPB, as evidenced by competitive experiments with heparin derivatives, soluble HS, and anti-HS antibodies. We then showed that target cells, i.e. CD4+ lymphocyte subsets, monocytes/macrophages, and related cell lines, specifically expressed high levels of NDST2 and 3-OST3 isoforms. Silencing the expression of NDST1, NDST2, 2-OST, and 3-OST3 by RNA interference efficiently decreased binding and activity of CyPB, thus confirming their involvement in the biosynthesis of binding sequences for CyPB. Moreover, we demonstrated that NDST1 was able to partially sulfate exogenous substrate in the absence of NDST2 but not vice versa, suggesting that both isoenzymes do not have redundant activities but do have rather complementary activities in making N-sulfated sequences with CyPB-binding properties. Altogether, these results suggest a regulatory mechanism in which cell type-specific expression of certain HS sulfotransferases determines the specific binding of CyPB to target cells. PMID:19940140

  13. Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases.

    Science.gov (United States)

    Deligny, Audrey; Denys, Agnès; Marcant, Adeline; Melchior, Aurélie; Mazurier, Joël; van Kuppevelt, Toin H; Allain, Fabrice

    2010-01-15

    Cyclophilin B (CyPB) induces migration and adhesion of T lymphocytes via a mechanism that requires interaction with 3-O-sulfated heparan sulfate (HS). HS biosynthesis is a complex process with many sulfotransferases involved. N-Deacetylases/N-sulfotransferases are responsible for N-sulfation, which is essential for subsequent modification steps, whereas 3-O-sulfotransferases (3-OSTs) catalyze the least abundant modification. These enzymes are represented by several isoforms, which differ in term of distribution pattern, suggesting their involvement in making tissue-specific HS. To elucidate how the specificity of CyPB binding is determined, we explored the relationships between the expression of these sulfotransferases and the generation of HS motifs with CyPB-binding properties. We demonstrated that high N-sulfate density and the presence of 2-O- and 3-O-sulfates determine binding of CyPB, as evidenced by competitive experiments with heparin derivatives, soluble HS, and anti-HS antibodies. We then showed that target cells, i.e. CD4+ lymphocyte subsets, monocytes/macrophages, and related cell lines, specifically expressed high levels of NDST2 and 3-OST3 isoforms. Silencing the expression of NDST1, NDST2, 2-OST, and 3-OST3 by RNA interference efficiently decreased binding and activity of CyPB, thus confirming their involvement in the biosynthesis of binding sequences for CyPB. Moreover, we demonstrated that NDST1 was able to partially sulfate exogenous substrate in the absence of NDST2 but not vice versa, suggesting that both isoenzymes do not have redundant activities but do have rather complementary activities in making N-sulfated sequences with CyPB-binding properties. Altogether, these results suggest a regulatory mechanism in which cell type-specific expression of certain HS sulfotransferases determines the specific binding of CyPB to target cells.

  14. Pericentrin expression in Down's syndrome.

    Science.gov (United States)

    Salemi, Michele; Barone, Concetta; Romano, Carmelo; Salluzzo, Roberto; Caraci, Filippo; Cantarella, Rita Anna; Salluzzo, Maria Grazia; Drago, Filippo; Romano, Corrado; Bosco, Paolo

    2013-11-01

    Down's syndrome (DS) is the most frequent genetic cause of intellectual disability and is a chromosomal abnormality of chromosome 21 trisomy. The pericentrin gene (PCNT) has sequenced in 21q22.3 inside of the minimal critical region for Down's syndrome. Alterations of PCNT gene are associated with dwarfism, cardiomyopathy and other pathologies. In this study, we have evaluated the possible differential expression of PCNT mRNA, by qRT-PCR, in peripheral blood leukocytes of DS subjects compared with the normal population. In the present case-control study, PCNT gene expression was increased by 72.72% in 16 out 22 DS samples compared with normal subjects. Our data suggest that changes in the expression levels of PCNT in DS subjects may be involved into the molecular mechanism of Down's syndrome.

  15. Converting nested algebra expressions into flat algebra expressions

    NARCIS (Netherlands)

    Paredaens, J.; Van Gucht, D.

    1992-01-01

    Nested relations generalize ordinary flat relations by allowing tuple values to be either atomic or set valued. The nested algebra is a generalization of the flat relational algebra to manipulate nested relations. In this paper we study the expressive power of the nested algebra relative to its

  16. EXPRESS Service to the International Space Station: EXPRESS Pallet

    Science.gov (United States)

    Primm, Lowell; Bergmann, Alan

    1998-01-01

    The International Space Station (ISS) will be the ultimate scientific accomplishment in the history of NASA, with its primary objective of providing unique scientific investigation opportunities. This objective is the basis for the creation of the EXPRESS Pallet System (ExPs). The EXPRESS Pallet will provide extremal/unpressurized accommodations for a wide variety of external users. The payload developers represent many science disciplines, including earth observation, communications, solar and deep space viewing, long-term exposure, and many others. The EXPRESS Pallet will provide a mechanism to maximum utilization of the limited ISS unpressurized payload volume, standard physical payload interfaces for users, a standard integration template for users and the capability to changeout payloads on-orbit. The EXPRESS Pallet provides access to Ram, Wake, Starboard, Port, Nadir, Zenith and Earth Limb for exposure and viewing. 'Me ExPs consists of the Pallet structure, payload Adapters, and a subsystem assembly which includes data controller, power distribution and conversion, and Extra Vehicular Robotics/Extra-Vehicular Activity systems.

  17. Construction of PVX virus-expression vector to express enterotoxin ...

    African Journals Online (AJOL)

    Potato X potyvirus (PVX)-based vector has been comprehensively applied in transient expression system. In order to produce the heterologous proteins more quickly and stably, the ClaI and NotI enzyme sites were introduced into the Enterotoxin fusion gene LTB-ST by polymerase chain reaction (PCR) and the LTB-ST ...

  18. Advanced express web application development

    CERN Document Server

    Keig, Andrew

    2013-01-01

    A practical book, guiding the reader through the development of a single page application using a feature-driven approach.If you are an experienced JavaScript developer who wants to build highly scalable, real-world applications using Express, this book is ideal for you. This book is an advanced title and assumes that the reader has some experience with node, Javascript MVC web development frameworks, and has heard of Express before, or is familiar with it. You should also have a basic understanding of Redis and MongoDB. This book is not a tutorial on Node, but aims to explore some of the more

  19. Gene expression in colorectal cancer

    DEFF Research Database (Denmark)

    Birkenkamp-Demtroder, Karin; Christensen, Lise Lotte; Olesen, Sanne Harder

    2002-01-01

    Understanding molecular alterations in colorectal cancer (CRC) is needed to define new biomarkers and treatment targets. We used oligonucleotide microarrays to monitor gene expression of about 6,800 known genes and 35,000 expressed sequence tags (ESTs) on five pools (four to six samples in each...... pool) of total RNA from left-sided sporadic colorectal carcinomas. We compared normal tissue to carcinoma tissue from Dukes' stages A-D (noninvasive to distant metastasis) and identified 908 known genes and 4,155 ESTs that changed remarkably from normal to tumor tissue. Based on intensive filtering 226...

  20. Correction of gene expression data

    DEFF Research Database (Denmark)

    Darbani Shirvanehdeh, Behrooz; Stewart, C. Neal, Jr.; Noeparvar, Shahin

    2014-01-01

    This report investigates for the first time the potential inter-treatment bias source of cell number for gene expression studies. Cell-number bias can affect gene expression analysis when comparing samples with unequal total cellular RNA content or with different RNA extraction efficiencies....... For maximal reliability of analysis, therefore, comparisons should be performed at the cellular level. This could be accomplished using an appropriate correction method that can detect and remove the inter-treatment bias for cell-number. Based on inter-treatment variations of reference genes, we introduce...

  1. Microsoft Expression Web for dummies

    CERN Document Server

    Hefferman, Linda

    2013-01-01

    Expression Web is Microsoft's newest tool for creating and maintaining dynamic Web sites. This FrontPage replacement offers all the simple ""what-you-see-is-what-you-get"" tools for creating a Web site along with some pumped up new features for working with Cascading Style Sheets and other design options. Microsoft Expression Web For Dummies arrives in time for early adopters to get a feel for how to build an attractive Web site. Author Linda Hefferman teams up with longtime FrontPage For Dummies author Asha Dornfest to show the easy way for first-time Web designers, FrontPage ve

  2. Expression and function of the SDF-1 chemokine receptors CXCR4 and CXCR7 during mouse limb muscle development and regeneration.

    Science.gov (United States)

    Hunger, Conny; Ödemis, Veysel; Engele, Jürgen

    2012-10-15

    The chemokine, SDF-1/CXCL12, and its receptor, CXCR4, have been implied to play major roles during limb myogenesis. This concept was recently challenged by the identification of CXCR7 as an alternative SDF-1 receptor, which can either act as a scavenger receptor, a modulator of CXCR4, or an active chemokine receptor. We have now re-examined this issue by determining whether SDF-1 would signal to C2C12 myoblasts and subsequently influence their differentiation via CXCR4 and/or CXCR7. In addition, we have analyzed CXCR7, CXCR4, and SDF-1 expression in developing and injured mouse limb muscles. We demonstrate that in undifferentiated C2C12 cells, SDF-1-dependent cell signaling and resulting inhibitory effects on myogenic differentiation are entirely mediated by CXCR4. We further demonstrate that CXCR7 expression increases in differentiating C2C12 cells, which in turn abrogates CXCR4 signaling. Moreover, consistent with the view that CXCR4 and CXCR7 control limb myogenesis in vivo by similar mechanisms, we found that CXCR4 expression is the highest in late embryonic hindlimb muscles and drops shortly after birth when secondary muscle growth terminates. Vice versa, CXCR7 expression increased perinatally and persisted into adult life. Finally, underscoring the role of the SDF-1 system in muscle regeneration, we observed that SDF-1 is continuously expressed by endomysial cells of postnatal and adult muscle fibers. Analysis of dystrophin-deficient mdx mice additionally revealed that muscle regeneration is associated with muscular re-expression of CXCR4. The apparent tight control of limb muscle development and regeneration by CXCR4 and CXCR7 points to these chemokine receptors as promising therapeutic targets for certain muscle disorders. Copyright © 2012 Elsevier Inc. All rights reserved.

  3. Dependency of Quality Education for Attaining the Health-related ...

    African Journals Online (AJOL)

    AJRH Managing Editor

    Dependency of Quality Education for Attaining the Health-related. Sustainable Development Goals in Africa. Peter A. Okebukola. Chairman of Council, Crawford University, Igbesa,Ogun State, Nigeria; former Executive Secretary, National Universities. Commission, Nigeria; and Special Adviser to the Vice-Chancellor, ...

  4. North Korean Civil-Military Trends: Military-First Politics to a Point

    Science.gov (United States)

    2006-09-01

    to the Great Leader. Yi Yong Mu. The NDC’s impact on the formal leadership lineup was made clear by 2001, when Yi Yong Mu, vice chairman of the NDC...to be restricted, as are career bonds that could come about between officers through sequential appointments to same commands. • First time

  5. 75 FR 9574 - Tehama County Resource Advisory Committee

    Science.gov (United States)

    2010-03-03

    ...) will meet in Red Bluff, California. Agenda items to be covered include: (1) Introductions, (2) Approval of Minutes, (3) Public Comment, (4) Chairman's Perspective, (5) Elect Vice Chairmen, (6) Next Agenda.... Individuals wishing to speak or propose agenda items must send their names and proposals to Randy Jero...

  6. 77 FR 17333 - Bylaws of the Board of Governors

    Science.gov (United States)

    2012-03-26

    ... Vice Chairman at any meeting of the Board during the year or years following the immediate past... amendments also formalized the process for notation voting (voting by paper ballot) on routine or... notation voting by paper ballot on routine, non-controversial, and administrative matters. List of Subjects...

  7. Is nuclear power safe enough

    International Nuclear Information System (INIS)

    Selberg, A.

    1979-01-01

    The vice-chairman of the Nuclear Power Safety Commission presents here the background for the Commission's work. He summarises informally the conclusions reached and quotes the minority dissensions. He also criticises many of the arguments made by anti-nuclear organisations. (JIW)

  8. 75 FR 13306 - Copyright Royalty Judges’ Authority to Subpoena a Nonparticipant to Appear and Give Testimony or...

    Science.gov (United States)

    2010-03-19

    .... 1305 (Office of Personnel Management & Merit Systems Protection Board may ``subpena witnesses and... or the vice chairman, the attendance and testimony of witnesses and the production of all documentary... the attendance and testimony of a witness, versus the mere authority to subpoena documentary...

  9. NIGERIA"'S RETURN TO t:IVILIAN IIIJL.:

    African Journals Online (AJOL)

    government His fellow officers understood the mood of the people ... Rule by officers alone is both brief and ... role' is. Corrective. Military Government.12. This form of government would appear to be a ..... Chief Awolowo vice-chairman of the Federal. Executive ..... with generous financial incentives was effected. Thus in July ...

  10. 77 FR 8807 - President's Export Council, Subcommittee on Export Administration; Notice of Open Meeting

    Science.gov (United States)

    2012-02-15

    ... diplomatic or trading relations and of controlling trade for national security and foreign policy reasons.... Welcome and remarks by Chairman and Vice Chair. 2. Presentation of Papers or Comments by the Public. 3. Review of Field Hearing. 4. Discussion/Status of 2012 Workplan. 5. Subcommittee Breakout Sessions. 6...

  11. The Economics of Sorruption and Cronyism: an institutional approach

    NARCIS (Netherlands)

    B. Krug (Barbara); H. Hendrischke (Hans)

    2001-01-01

    textabstractMoral outrage was the response of the Chinese press, when Cheng Kejie, one of the country's highest officials, Vice-Chairman of the Standing Committee of the National People's Congress (NPC) and former Governor of the Guangxi Zhuang Autonomous Region, was arrested on grounds of

  12. 77 FR 47490 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-08-08

    ...: --Adoption of the agenda --Decisions of other IMO bodies --Global Maritime Distress and Safety System (GMDSS... facilities --Consideration of operational and technical coordination provisions of maritime safety... Vice-Chairman for 2014 --Any other business --Report to the Maritime Safety Committee Members of the...

  13. 75 FR 35873 - Meeting; Shipping Coordinating Committee

    Science.gov (United States)

    2010-06-23

    ... Report. --Status of Constituent and Other Instruments. --Global Maritime Distress and Safety Systems... Vice-Chairman for 2012. --Any other business. --Report to the Maritime Safety Committee. The primary... purpose of the July 28 SHC meeting is to prepare for the fifty-third Session of the International Maritime...

  14. LOCAL ORGANIZING COMMITTEE

    Indian Academy of Sciences (India)

    Prof. B. B. P. Gupta

    INDIAN ACADEMY OF SCIENCES. Bengaluru. 83rd ANNUAL MEETING. 3–5 November 2017, NEHU, Shillong. LOCAL ORGANIZING COMMITTEE. Local Organizing Committee. 1. Prof. S. K. Srivastava. Chairman. Vice-Chancellor, NEHU, Shillong. 2. Prof. B. B. P. Gupta. Organising Secretary. Department of Zoology ...

  15. A Future Outlook for Women Executives.

    Science.gov (United States)

    1988-04-01

    revive Kentucky Fried Chicken . Maryann Schneider, 40; Beneficial Corp., Wilmington, Del.; senior vice-president for planning and administration; KS...Marion 0. Sandler -- co-chairman of the Golden West Financial Corporation, which has $34 billion dollars in assets, and Wendy Luscombe -- President of Pan

  16. 75 FR 12748 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-03-17

    ... Shipping & Logistics, LLC, 10651 SW. 108 Avenue, 3A, Miami, FL 33176, Officers: Lorenzo A. Macias... Castleton Street, 263, City of Industry, CA 91748, Officers: Hua Yang, Vice President, (Qualifying Individual), Zhenfen Wu, Chairman. Qingfeng Wang dba Global Intertrans Logistics, 200 East Norwood Place, San...

  17. Report of the Comptroller General of the United States. Comments on selected aspects of the Administration's proposal for government assistance to private uranium enrichment groups

    International Nuclear Information System (INIS)

    1976-01-01

    This report presents GAO's views on matters raised by the Vice Chairman, Joint Committee on Atomic Energy, related to the private ownership of uranium enrichment and reemphasizes GAO's belief that the Government should add on to one of its existing enrichment plants to provide the next increment of enrichment capacity

  18. Retirement, Work, and Lifelong Learning; Hearing Before the Special Committee on Aging, Ninety-Fifth Congress, Second Session. Part 3.

    Science.gov (United States)

    Arizona State Dept. of Economic Planning and Development, Phoenix.

    The transcripts of the testimony given before the Senate Committee by the Chairman of the Civil Service Commission, Alan Campbell, and Stanley Babson, management consultant and former vice president of finance for Technicon Corporation, are presented. Statements address the following issues of concern: age discrimination, management of job skills,…

  19. 77 FR 69599 - Reserve Forces Policy Board (RFPB); Notice of Advisory Committee Meeting

    Science.gov (United States)

    2012-11-20

    ... force mix; the Vice Chairman of the Joint Chiefs of Staff will discuss Operational Reserve Requirements... DEPARTMENT OF DEFENSE Office of the Secretary Reserve Forces Policy Board (RFPB); Notice of Advisory Committee Meeting AGENCY: Reserve Forces Policy Board, Office of the Secretary of Defense...

  20. Socio-economic impact of biofuel feedstock production on local ...

    African Journals Online (AJOL)

    is followed by a discussion on the state of biofuel investments in Ghana. ... which a person or household commands and can use towards a livelihood (Chambers and ... Nyari (2008) reports that agriculture accounts for more than 90% of .... Bakari Nyari, Vice Chairman of Regional Advisory and Information Network Systems.

  1. 76 FR 7598 - Self-Regulatory Organizations; C2 Options Exchange, Incorporated; Notice of Filing of a Proposed...

    Science.gov (United States)

    2011-02-10

    ... its Bylaws to eliminate its Audit Committee. The text of the proposed amendments to C2's Bylaws and... the C2 Audit Committee. (a) Elimination of Office of Vice Chairman of the Board Based on the Exchange... role in facilitating communication between C2 and its Trading Permit Holders and in coordinating the...

  2. 76 FR 17974 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Order Approving...

    Science.gov (United States)

    2011-03-31

    ... provide that the Board of Directors may establish an Advisory Board instead; (3) eliminate the CBOE Audit...\\ Historically, the Vice Chairman's primary function was to facilitate communication between the Exchange and its... through other channels, including direct communication with individual Trading Permit Holders, committees...

  3. The change of expression configuration affects identity-dependent expression aftereffect but not identity-independent expression aftereffect

    Directory of Open Access Journals (Sweden)

    Miao eSong

    2015-12-01

    Full Text Available The present study examined the influence of expression configuration on cross-identity expression aftereffect. The expression configuration refers to the spatial arrangement of facial features in a face for conveying an emotion, e.g., an open-mouth smile versus a closed-mouth smile. In the first of two experiments, the expression aftereffect is measured using across-identity/cross-expression configuration factorial design. The facial identities of test faces were the same or different from the adaptor, while orthogonally, the expression configurations of those facial identities were also the same or different. The result shows that the change of expression configuration impaired the expression aftereffect when the facial identities of adaptor and tests were the same; however, the impairment effect disappears when facial identities were different, indicating the identity-independent expression representation is more robust to the change of the expression configuration in comparison with the identity-dependent expression representation. In the second experiment, we used schematic line faces as adaptors and real faces as tests to minimize the similarity between the adaptor and tests, which is expected to exclude the contribution from the identity-dependent expression representation to expression aftereffect. The second experiment yields a similar result as the identity-independent expression aftereffect observed in Experiment 1. The findings indicate the different neural sensitivities to expression configuration for identity-dependent and identity-independent expression systems.

  4. 'Endurance' Courtesy of Mars Express

    Science.gov (United States)

    2004-01-01

    NASA's Mars Exploration Rover Opportunity used its panoramic camera to capture this false-color image of the interior of 'Endurance Crater' on the rover's 188th martian day (Aug. 4, 2004). The image data were relayed to Earth by the European Space Agency's Mars Express orbiter. The image was generated from separate frames using the cameras 750-, 530- and 480-nanometer filters.

  5. Communicating emotions in expressive avatars

    NARCIS (Netherlands)

    Kierkegaard, P.M.

    2010-01-01

    Avatars have become a fundamental part of collaborative virtual environments. They are the visual embodiment of the user and are designed to address key issues in the interaction process between the user and the CVE. Giving avatars expressive abilities has been considered essential in computer-human

  6. Spirit Boxes: Expressions of Culture.

    Science.gov (United States)

    DeMuro, Ted

    1984-01-01

    After studying the culture and art of the ancient civilizations of South America, Mesopotamia, Greece, and Egypt, secondary level art students made spirit boxes as expressions of the various cultures. How to make the boxes and how to prepare the face molds are described. (RM)

  7. Mapping and Manipulating Facial Expression

    Science.gov (United States)

    Theobald, Barry-John; Matthews, Iain; Mangini, Michael; Spies, Jeffrey R.; Brick, Timothy R.; Cohn, Jeffrey F.; Boker, Steven M.

    2009-01-01

    Nonverbal visual cues accompany speech to supplement the meaning of spoken words, signify emotional state, indicate position in discourse, and provide back-channel feedback. This visual information includes head movements, facial expressions and body gestures. In this article we describe techniques for manipulating both verbal and nonverbal facial…

  8. The SSETI-express Mission

    DEFF Research Database (Denmark)

    Alminde, Lars; Bisgaard, Morten; Melville, N.

    In January 2004 a group of students met at the European Space Technology and Research Centre (ESTEC) in Holland to discuss the feasibility of building a micro-satellite, dubbed SSETI-Express, from parts derived from other student satellite projects and launch it within one and a half year...

  9. The SSETI-Express Mission

    DEFF Research Database (Denmark)

    Alminde, Lars; Bisgaard, Morten; Melville, Neil

    2005-01-01

    In January 2004 a group of students met at the European Space Technology and Research Centre (ESTEC) in Holland to discuss the feasibility of building a micro-satellite, dubbed SSETI-Express, from parts derived from other student satellite projects and launch it within one and a half year...

  10. The motivation to express prejudice.

    Science.gov (United States)

    Forscher, Patrick S; Cox, William T L; Graetz, Nicholas; Devine, Patricia G

    2015-11-01

    Contemporary prejudice research focuses primarily on people who are motivated to respond without prejudice and the ways in which unintentional bias can cause these people to act in a manner inconsistent with this motivation. However, some real-world phenomena (e.g., hate speech, hate crimes) and experimental findings (e.g., Plant & Devine, 2001, 2009) suggest that some prejudice is intentional. These phenomena and findings are difficult to explain solely from the motivations to respond without prejudice. We argue that some people are motivated to express prejudice, and we develop the Motivation to Express Prejudice Scale (MP) to measure this motivation. In 7 studies involving more than 6,000 participants, we demonstrate that, across scale versions targeted at Black people and gay men, the MP has good reliability and convergent, discriminant, and predictive validity. In normative climates that prohibit prejudice, the internal and external motivations to express prejudice are functionally nonindependent, but they become more independent when normative climates permit more prejudice toward a target group. People high in the motivation to express prejudice are relatively likely to resist pressure to support programs promoting intergroup contact and to vote for political candidates who support oppressive policies. The motivation to express prejudice predicted these outcomes even when controlling for attitudes and the motivations to respond without prejudice. This work encourages contemporary prejudice researchers to give greater consideration to the intentional aspects of negative intergroup behavior and to broaden the range of phenomena, target groups, and samples that they study. (c) 2015 APA, all rights reserved).

  11. Vascular Gene Expression: A Hypothesis

    Directory of Open Access Journals (Sweden)

    Angélica Concepción eMartínez-Navarro

    2013-07-01

    Full Text Available The phloem is the conduit through which photoassimilates are distributed from autotrophic to heterotrophic tissues and is involved in the distribution of signaling molecules that coordinate plant growth and responses to the environment. Phloem function depends on the coordinate expression of a large array of genes. We have previously identified conserved motifs in upstream regions of the Arabidopsis genes, encoding the homologs of pumpkin phloem sap mRNAs, displaying expression in vascular tissues. This tissue-specific expression in Arabidopsis is predicted by the overrepresentation of GA/CT-rich motifs in gene promoters. In this work we have searched for common motifs in upstream regions of the homologous genes from plants considered to possess a primitive vascular tissue (a lycophyte, as well as from others that lack a true vascular tissue (a bryophyte, and finally from chlorophytes. Both lycophyte and bryophyte display motifs similar to those found in Arabidopsis with a significantly low E-value, while the chlorophytes showed either a different conserved motif or no conserved motif at all. These results suggest that these same genes are expressed coordinately in non- vascular plants; this coordinate expression may have been one of the prerequisites for the development of conducting tissues in plants. We have also analyzed the phylogeny of conserved proteins that may be involved in phloem function and development. The presence of CmPP16, APL, FT and YDA in chlorophytes suggests the recruitment of ancient regulatory networks for the development of the vascular tissue during evolution while OPS is a novel protein specific to vascular plants.

  12. DNA expressions - A formal notation for DNA

    NARCIS (Netherlands)

    Vliet, Rudy van

    2015-01-01

    We describe a formal notation for DNA molecules that may contain nicks and gaps. The resulting DNA expressions denote formal DNA molecules. Different DNA expressions may denote the same molecule. Such DNA expressions are called equivalent. We examine which DNA expressions are minimal, which

  13. Recombination-ready Sindbis replicon expression vectors for transgene expression

    Directory of Open Access Journals (Sweden)

    Olson Ken E

    2007-10-01

    Full Text Available Abstract Background Sindbis viruses have been widely used as tools to study gene function in cells. Despite the utility of these systems, the construction and production of alphavirus replicons is time consuming and inefficient due to potential additional restriction sites within the insert region and lack of directionality for insert ligation. In this report, we present a system useful for producing recombinant Sindbis replicons that uses lambda phage recombination technology to rapidly and specifically construct replicon expression plasmids that contain insert regions in the desired orientation. Results Recombination of the gene of interest with the replicon plasmid resulted in nearly 100% recombinants, each of which contained a correctly orientated insert. Replicons were easily produced in cell culture and packaged into pseudo-infectious viral particles. Insect and mammalian cells infected with pseudo-infectious viral particles expressed various transgenes at high levels. Finally, inserts from persistently replicating replicon RNA were easily isolated and recombined back into entry plasmids for sequencing and subsequent analysis. Conclusion Replication-ready replicon expression plasmids make the use of alphavirus replicons fast and easy as compared to traditional replicon production methods. This system represents a significant step forward in the utility and ease of use of alphavirus replicons in the study of gene function.

  14. Dynamic Facial Expression of Emotion Made Easy

    OpenAIRE

    Broekens, Joost; Qu, Chao; Brinkman, Willem-Paul

    2012-01-01

    Facial emotion expression for virtual characters is used in a wide variety of areas. Often, the primary reason to use emotion expression is not to study emotion expression generation per se, but to use emotion expression in an application or research project. What is then needed is an easy to use and flexible, but also validated mechanism to do so. In this report we present such a mechanism. It enables developers to build virtual characters with dynamic affective facial expressions. The mecha...

  15. A Brief Introduction of Air Traffic Management

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    Air Traffic Management (ATM) started publication in 1995 by Air Traffic Management Bureau of CAAC. It is the first magazine about ATM field in CAAC. The chairman of Editorial Board of ATM is Mr. Bao Peide, Vice Minister of CAAC. Mr. Chen Ziye, Vice President of the 1st Research Institute of CAAC and Chen Xuhua, General Director of Air Traffic Management Bureau are vice chairmen of the editorial board, and six general directors of local air traffic management bureau and some professors and experts are members of the editorial board.

  16. Emotional Expression in Reality TV

    DEFF Research Database (Denmark)

    Rasmussen, Tove Arendt

    Reality TV has been disputed and discussed along many lines for the last 20 years; the media themselves always with a twist of concern about reality programs crossing moral borderlines while research has put more interest in questions of genre and representation of more or less useful and maybe...... empowering social identities. In the latest generation of reality TV which Misha Kava has described as the “celebrity generation”, it seems that reality creates new standards for mixing facts and fiction and even different “realities” as participants become media stars while more traditional celebrities...... are being treated as ordinary people. My article will discuss different presentations of selves and especially the emotional verbal and nonverbal expressions in reality TV communication. Aspects of the intimate self and its emotional expressions seem to be strategically managed in reality TV and even...

  17. On the Expressiveness of Joining

    Directory of Open Access Journals (Sweden)

    Thomas Given-Wilson

    2015-08-01

    Full Text Available The expressiveness of communication primitives has been explored in a common framework based on the pi-calculus by considering four features: synchronism (asynchronous vs synchronous, arity (monadic vs polyadic data, communication medium (shared dataspaces vs channel-based, and pattern-matching (binding to a name vs testing name equality vs intensionality. Here another dimension coordination is considered that accounts for the number of processes required for an interaction to occur. Coordination generalises binary languages such as pi-calculus to joining languages that combine inputs such as the Join Calculus and general rendezvous calculus. By means of possibility/impossibility of encodings, this paper shows coordination is unrelated to the other features. That is, joining languages are more expressive than binary languages, and no combination of the other features can encode a joining language into a binary language. Further, joining is not able to encode any of the other features unless they could be encoded otherwise.

  18. Architecture between construction and expression

    Directory of Open Access Journals (Sweden)

    Luca Lanini

    2015-11-01

    Full Text Available I think that the problem is basically the same as always: to redefine the relationship between Construction and Expression. On one hand, construction is considered an endeavor, on the other hand, a tendency to contest architecture only with expression. The relationship between architecture and control of urban phenomena is a relationship that has been gradually lost in the past three decades and has been replaced by the relationship between finance and planning. A useful object is very different from a building: for its time and costs of construction. Buildings are expected to last many years and are paid with everybody’s taxes, a design object’s lifespan is perhaps fifty years, then it’s ready to be modernized or for the landfill ... I believe that the main tool that a designer must have, beyond necessary technical skills, is the capacity of his/her own critical thought.

  19. Malignant Trigeminal Nerve Sheath Tumor and Anaplastic Astrocytoma Collision Tumor with High Proliferative Activity and Tumor Suppressor P53 Expression

    Directory of Open Access Journals (Sweden)

    Maher Kurdi

    2014-01-01

    Full Text Available Background. The synchronous development of two primary brain tumors of distinct cell of origin in close proximity or in contact with each other is extremely rare. We present the first case of collision tumor with two histological distinct tumors. Case Presentation. A 54-year-old woman presented with progressive atypical left facial pain and numbness for 8 months. MRI of the brain showed left middle cranial fossa heterogeneous mass extending into the infratemporal fossa. At surgery, a distinct but intermingled intra- and extradural tumor was demonstrated which was completely removed through left orbitozygomatic-temporal craniotomy. Histopathological examination showed that the tumor had two distinct components: malignant nerve sheath tumor of the trigeminal nerve and temporal lobe anaplastic astrocytoma. Proliferative activity and expressed tumor protein 53 (TP53 gene mutations were demonstrated in both tumors. Conclusions. We describe the first case of malignant trigeminal nerve sheath tumor (MTNST and anaplastic astrocytoma in collision and discuss the possible hypothesis of this rare occurrence. We propose that MTNST, with TP53 mutation, have participated in the formation of anaplastic astrocytoma, or vice versa.

  20. Transgenic Arabidopsis Gene Expression System

    Science.gov (United States)

    Ferl, Robert; Paul, Anna-Lisa

    2009-01-01

    The Transgenic Arabidopsis Gene Expression System (TAGES) investigation is one in a pair of investigations that use the Advanced Biological Research System (ABRS) facility. TAGES uses Arabidopsis thaliana, thale cress, with sensor promoter-reporter gene constructs that render the plants as biomonitors (an organism used to determine the quality of the surrounding environment) of their environment using real-time nondestructive Green Fluorescent Protein (GFP) imagery and traditional postflight analyses.

  1. Podoplanin Expression in Canine Melanoma

    OpenAIRE

    Ogasawara, Satoshi; Honma, Ryusuke; Kaneko, Mika K.; Fujii, Yuki; Kagawa, Yumiko; Konnai, Satoru; Kato, Yukinari

    2016-01-01

    A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein, we investigated whether PMab-38 reacts with canine melanoma. PMab-38 reacted with 90% of melanoma cells (9/10 cases) using immunohistochemistr...

  2. Summer Oral Expression English Course

    CERN Document Server

    HR Department

    2011-01-01

    An English Oral Expression course will take place between 15 August and 30 September 2011. Schedule: to be determined (2 sessions of 2 hours per week). Please note that this course is for learners who have a good knowledge of English (CERN level 7 upwards). If you are interested in following this course, please enrol here. Or contact: Kerstin FUHRMEISTER (70896) Tessa OSBORNE (72957)  

  3. Nitrate signals determine the sensing of nitrogen through differential expression of genes involved in nitrogen uptake and assimilation in finger millet.

    Science.gov (United States)

    Gupta, Alok Kumar; Gaur, Vikram Singh; Gupta, Sanjay; Kumar, Anil

    2013-06-01

    In order to understand the molecular basis of high nitrogen use efficiency of finger millet, five genes (EcHNRT2, EcLNRT1, EcNADH-NR, EcGS, and EcFd-GOGAT) involved in nitrate uptake and assimilation were isolated using conserved primer approaches. Expression profiles of these five genes along with the previously isolated EcDof1 was studied under increased KNO3 concentrations (0.15 to 1,500 μM) for 2 h as well as at 1.5 μM for 24 h in the roots and shoots of 25 days old nitrogen deprived two contrasting finger millet genotypes (GE-3885 and GE-1437) differing in grain protein content (13.76 and 6.15 %, respectively). Time kinetics experiment revealed that, all the five genes except EcHNRT2 in the leaves of GE-3885 were induced within 30 min of nitrate exposure indicating that there might be a greater nitrogen deficit in leaves and therefore quick transportation of nitrate signals to the leaves. Exposing the plants to increasing nitrate concentrations for 2 h showed that in roots of GE-3885, NR was strongly induced while GS was repressed; however, the pattern was found to be reversed in leaves of GE-1437 indicating that in GE-3885, most of the nitrate might be reduced in the roots but assimilated in leaves and vice-versa. Furthermore, compared with the low-protein genotype, expression of HNRT2 was strongly induced in both roots and shoots of high-protein genotype at the least nitrate concentration supplied. This further indicates that GE-3885 is a quick sensor of nitrogen compared with the low-protein genotype. Furthermore, expression of EcDof1 was also found to overlap the expression of NR, GS, and GOGAT indicating that Dof1 probably regulates the expression of these genes under different conditions by sensing the nitrogen fluctuations around the root zone.

  4. Children's expression through play therapy

    Directory of Open Access Journals (Sweden)

    Ljubomirović Nataša

    2015-01-01

    Full Text Available Play as a child's expression, is a skill through which children speaks to adults. Play therapy is a broad field of therapeutic intervention based on the play in order to help the child to cope with problems. Through play, children learn to communicate with others, to express their feelings. Through play they learn and can improve their cognitive, emotional and social capabilities. Play therapy is a nondirective technique focused on the child. It is not focused on the problem, at present even the past, but focused on the expression of the child feelings, accepting the child, rather than correction. The focus has been on the wisdom of a child, not on expertise therapists, guiding the child through play rather than instructing. The aim of play therapy is to encourage healthy growth and development, developing skills in problem solving, reduction of undesirable behavior, confidence building and the development of self-control. This method is effective for a wide range of children's problems, such as the state of stress, anxiety, problem behavior, hyperkinetic syndrome, depression, loss, trauma, the problem of bonding situations parents divorced, somatic disorders, autism spectrum disorders, social problems.

  5. Gene expression profile of pulpitis.

    Science.gov (United States)

    Galicia, J C; Henson, B R; Parker, J S; Khan, A A

    2016-06-01

    The cost, prevalence and pain associated with endodontic disease necessitate an understanding of the fundamental molecular aspects of its pathogenesis. This study was aimed to identify the genetic contributors to pulpal pain and inflammation. Inflamed pulps were collected from patients diagnosed with irreversible pulpitis (n=20). Normal pulps from teeth extracted for various reasons served as controls (n=20). Pain level was assessed using a visual analog scale (VAS). Genome-wide microarray analysis was performed using Affymetrix GeneTitan Multichannel Instrument. The difference in gene expression levels were determined by the significance analysis of microarray program using a false discovery rate (q-value) of 5%. Genes involved in immune response, cytokine-cytokine receptor interaction and signaling, integrin cell surface interactions, and others were expressed at relatively higher levels in the pulpitis group. Moreover, several genes known to modulate pain and inflammation showed differential expression in asymptomatic and mild pain patients (⩾30 mm on VAS) compared with those with moderate to severe pain. This exploratory study provides a molecular basis for the clinical diagnosis of pulpitis. With an enhanced understanding of pulpal inflammation, future studies on treatment and management of pulpitis and on pain associated with it can have a biological reference to bridge treatment strategies with pulpal biology.

  6. Modulation of sodium-bicarbonate co-transporter (SLC4A4/NBCe1) protein and mRNA expression in rat's uteri by sex-steroids and at different phases of the oestrous cycle.

    Science.gov (United States)

    Gholami, Khadijeh; Muniandy, Sekaran; Salleh, Naguib

    2014-02-01

    Oestrogen-induced uterine fluid sodium (Na(+)) and bicarbonate (HCO3(-)) secretion may involve SLC4A4. We hypothesized that uterine SLC4A4 expression changes under different sex-steroid influence, therefore may account for the fluctuation in uterine fluid Na(+) and HCO3(-) content throughout the oestrous cycle. The aim of this study is to investigate the differential effects of sex-steroids and oestrous cycle phases on uterine SLC4A4 expression. Adult female WKY rats were ovariectomised and treated with different doses of 17β-oestradiol (E2) (0.2, 2, 20 and 50 μg/ml/day) or progesterone (P4) (4 mg/ml/day) for three consecutive days and 3 days treatment with 0.2 μg/ml/day E2 followed by another 3 days with P4 to mimic the hormonal changes in early pregnancy. Oestrous cycle phases in intact, non-ovariectomised rats were determined by vaginal smear. The animals were then sacrificed and uteri were removed for protein and mRNA expression analyses by Western blotting and Real Time PCR, respectively. SLC4A4 distribution was observed by immunohistochemistry. Treatment with increasing E2 doses resulted in a dose-dependent increase in SLC4A4 protein expression. High SLC4A4 protein and mRNA expression can be seen at estrus. SLC4A4 is distributed mainly at the apical as well as basolateral membranes of the luminal and glandular epithelia following E2 treatment and at Es. Meanwhile, SLC4A4 expression was reduced following P4 treatment and was low at diestrus. High SLC4A4 expression under estrogen dominance may contribute to the increase in uterine fluid Na(+) and HCO3(-) content, while its low expression under P4 dominance may result in vice versa. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Cytokinins and auxins control the expression of a gene in Nicotiana plumbaginifolia cells by feedback regulation.

    Science.gov (United States)

    Dominov, J A; Stenzler, L; Lee, S; Schwarz, J J; Leisner, S; Howell, S H

    1992-01-01

    Both cytokinin (N6-benzyladenine [BA]) and auxin (2,4-dichlorophenoxyacetic acid [2,4-D]) stimulate the accumulation of an mRNA, represented by the cDNA pLS216, in Nicotiana plumbaginifolia suspension culture cells. The kinetics of RNA accumulation were different for the two hormones; however, the response to both was transient, and the magnitude of the response was dose dependent. Runoff transcription experiments demonstrated that the transient appearance of the RNA could be accounted for by feedback regulation of transcription and not by the induction of an RNA degradation system. The feedback mechanism appeared to desensitize the cells to further exposure of the hormone. In particular, cells became refractory to the subsequent addition of 2,4-D after the initial RNA accumulation response subsided. A very different response was observed when the second hormone was added to cells that had been desensitized to the first hormone. Under such conditions, BA produced a heightened response in cells desensitized to 2,4-D and vice versa. These findings support a model in which cytokinin further enhances the auxin response or prevents its feedback inhibition. The hormone-induced RNA accumulation was blocked by the protein kinase inhibitor staurosporin. On the other hand, the protein phosphatase inhibitor okadaic acid stimulated expression, and, in particular, okadaic acid was able to stimulate RNA accumulation in cells desensitized to auxin. This suggests that hormone activation involves phosphorylation of critical proteins on the hormone signaling pathway, whereas feedback inhibition may involve dephosphorylation of these proteins. The sequence of pLS216 is similar to genes in other plants that are stimulated by multiple agonists such as auxins, elicitors, and heavy metals, and to the gene encoding the stringent starvation protein in Escherichia coli. It is proposed that this gene family in various plants be called multiple stimulus response (msr) genes. PMID:1498603

  8. Functional analysis of aldehyde oxidase using expressed chimeric enzyme between monkey and rat.

    Science.gov (United States)

    Itoh, Kunio; Asakawa, Tasuku; Hoshino, Kouichi; Adachi, Mayuko; Fukiya, Kensuke; Watanabe, Nobuaki; Tanaka, Yorihisa

    2009-01-01

    Aldehyde oxidase (AO) is a homodimer with a subunit molecular mass of approximately 150 kDa. Each subunit consists of about 20 kDa 2Fe-2S cluster domain storing reducing equivalents, about 40 kDa flavine adenine dinucleotide (FAD) domain and about 85 kDa molybdenum cofactor (MoCo) domain containing a substrate binding site. In order to clarify the properties of each domain, especially substrate binding domain, chimeric cDNAs were constructed by mutual exchange of 2Fe-2S/FAD and MoCo domains between monkey and rat. Chimeric monkey/rat AO was referred to one with monkey type 2Fe-2S/FAD domains and a rat type MoCo domain. Rat/monkey AO was vice versa. AO-catalyzed 2-oxidation activities of (S)-RS-8359 were measured using the expressed enzyme in Escherichia coli. Substrate inhibition was seen in rat AO and chimeric monkey/rat AO, but not in monkey AO and chimeric rat/monkey AO, suggesting that the phenomenon might be dependent on the natures of MoCo domain of rat. A biphasic Eadie-Hofstee profile was observed in monkey AO and chimeric rat/monkey AO, but not rat AO and chimeric monkey/rat AO, indicating that the biphasic profile might be related to the properties of MoCo domain of monkey. Two-fold greater V(max) values were observed in monkey AO than in chimeric rat/monkey AO, and in chimeric monkey/rat AO than in rat AO, suggesting that monkey has the more effective electron transfer system than rat. Thus, the use of chimeric enzymes revealed that 2Fe-2S/FAD and MoCo domains affect the velocity and the quantitative profiles of AO-catalyzed (S)-RS-8359 2-oxidation, respectively.

  9. Children's Representations of Facial Expression and Identity: Identity-Contingent Expression Aftereffects

    Science.gov (United States)

    Vida, Mark D.; Mondloch, Catherine J.

    2009-01-01

    This investigation used adaptation aftereffects to examine developmental changes in the perception of facial expressions. Previous studies have shown that adults' perceptions of ambiguous facial expressions are biased following adaptation to intense expressions. These expression aftereffects are strong when the adapting and probe expressions share…

  10. Nonverbal and verbal emotional expression and health.

    Science.gov (United States)

    Berry, D S; Pennebaker, J W

    1993-01-01

    The spontaneous nonverbal expression of emotion is related to immediate reductions in autonomic nervous system activity. Similar changes in specific autonomic channels occur when individuals are encouraged to verbally express their emotions. Indeed, these physiological changes are most likely to occur among individuals who are either verbally or nonverbally highly expressive. These data suggest that when individuals must actively inhibit emotional expression, they are at increased risk for a variety of health problems. Several experiments are summarized which indicate that verbally expressing traumatic experiences by writing or talking improves physical health, enhances immune function, and is associated with fewer medical visits. Although less research is available regarding nonverbal expression, it is also likely that the nonverbal expression of emotion bears some relation to health status. We propose that the effectiveness of many common expressive therapies (e.g., art, music, cathartic) would be enhanced if clients are encouraged to both express their feelings nonverbally and to put their experiences into words.

  11. Misrecognition of facial expressions in delinquents

    Directory of Open Access Journals (Sweden)

    Matsuura Naomi

    2009-09-01

    Full Text Available Abstract Background Previous reports have suggested impairment in facial expression recognition in delinquents, but controversy remains with respect to how such recognition is impaired. To address this issue, we investigated facial expression recognition in delinquents in detail. Methods We tested 24 male adolescent/young adult delinquents incarcerated in correctional facilities. We compared their performances with those of 24 age- and gender-matched control participants. Using standard photographs of facial expressions illustrating six basic emotions, participants matched each emotional facial expression with an appropriate verbal label. Results Delinquents were less accurate in the recognition of facial expressions that conveyed disgust than were control participants. The delinquents misrecognized the facial expressions of disgust as anger more frequently than did controls. Conclusion These results suggest that one of the underpinnings of delinquency might be impaired recognition of emotional facial expressions, with a specific bias toward interpreting disgusted expressions as hostile angry expressions.

  12. Cloning and expression of a widely expressed receptor tyrosine phosphatase

    DEFF Research Database (Denmark)

    Sap, J; D'Eustachio, P; Givol, D

    1990-01-01

    We describe the identification of a widely expressed receptor-type (transmembrane) protein tyrosine phosphatase (PTPase; EC 3.1.3.48). Screening of a mouse brain cDNA library under low-stringency conditions with a probe encompassing the intracellular (phosphatase) domain of the CD45 lymphocyte...... antigen yielded cDNA clones coding for a 794-amino acid transmembrane protein [hereafter referred to as receptor protein tyrosine phosphatase alpha (R-PTP-alpha)] with an intracellular domain displaying clear homology to the catalytic domains of CD45 and LAR (45% and 53%, respectively). The 142-amino acid...

  13. Telecommunications Technology: Federal Funding for Schools and Libraries. Report to the Chairman, Committee on Commerce, and the Chairman, Committee on Education and the Workforce, House of Representatives.

    Science.gov (United States)

    General Accounting Office, Washington, DC. Health, Education, and Human Services Div.

    This document reports on federally created or facilitated programs for helping schools and libraries with their telecommunications and information technology efforts. Brief answers to specific questions on program characteristics, potential for duplication, coordination efforts, and available information on fraud, waste, and abuse are provided in…

  14. Summer Oral Expression English course

    CERN Multimedia

    2012-01-01

    An English Oral Expression course will take place this summer from 20 August to 29 September.   Schedule: to be determined (2 sessions of 2 hours per week). Please note that this course is for learners who have a good knowledge of English (CERN level 7 upwards). If you are interested in following this course, please enroll through this link. Please be sure to indicate your planned absences in the comments field so we can schedule the course. If you need more information please send a message to English.training@cern.ch

  15. Summer Oral Expression English course

    CERN Document Server

    2012-01-01

    An English Oral Expression course will take place this summer at some time between 25 June and 28 September. The exact dates will be decided according to the preferences of the students.   Schedule: to be determined (2 sessions of 2 hours per week). Please note that this course is for learners who have a good knowledge of English (CERN level 7 upwards). If you are interested in following this course, please enroll through this link. Please be sure to indicate your planned absences in the comments field so we can schedule the course. If you need more information please send a message to English.training@cern.ch

  16. Summer Oral Expression English course

    CERN Document Server

    2013-01-01

    An English Oral Expression course will take place this summer at some time between August 19 and October 4.   Schedule: to be determined (2 sessions of 2 hours per week). Please note that this course is for learners who have a good knowledge of English (CERN level 7 upwards). If you are interested in following this course, please enroll through this link. Please be sure to indicate your planned absences in the comments field so we can schedule the course. If you need more information please send a message to English.training@cern.ch.

  17. Summer Oral Expression English Course

    CERN Multimedia

    HR Department

    2011-01-01

    An English Oral Expression course will take place between 15 August and 30 September 2011. Schedule: to be determined (2 sessions of 2 hours per week). Please note that this course is for learners who have a good knowledge of English (CERN level 7 upwards). If you are interested in following this course, please enrol through the following link https://cta.cern.ch/cta2/f?p=110:9:1576796470009589::::X_STATUS,XS_COURSE_NAME,XS_PROGRAMME,XS_SUBCATEGORY,X_COURSE_ID,XS_LANGUAGE,XS_SESSION:D,,1,,4368,B, Or contact: Kerstin FUHRMEISTER (70896) Tessa OSBORNE (72957)  

  18. Global expression differences and tissue specific expression differences in rice evolution result in two contrasting types of differentially expressed genes

    KAUST Repository

    Horiuchi, Youko

    2015-12-23

    Background Since the development of transcriptome analysis systems, many expression evolution studies characterized evolutionary forces acting on gene expression, without explicit discrimination between global expression differences and tissue specific expression differences. However, different types of gene expression alteration should have different effects on an organism, the evolutionary forces that act on them might be different, and different types of genes might show different types of differential expression between species. To confirm this, we studied differentially expressed (DE) genes among closely related groups that have extensive gene expression atlases, and clarified characteristics of different types of DE genes including the identification of regulating loci for differential expression using expression quantitative loci (eQTL) analysis data. Results We detected differentially expressed (DE) genes between rice subspecies in five homologous tissues that were verified using japonica and indica transcriptome atlases in public databases. Using the transcriptome atlases, we classified DE genes into two types, global DE genes and changed-tissues DE genes. Global type DE genes were not expressed in any tissues in the atlas of one subspecies, however changed-tissues type DE genes were expressed in both subspecies with different tissue specificity. For the five tissues in the two japonica-indica combinations, 4.6 ± 0.8 and 5.9 ± 1.5 % of highly expressed genes were global and changed-tissues DE genes, respectively. Changed-tissues DE genes varied in number between tissues, increasing linearly with the abundance of tissue specifically expressed genes in the tissue. Molecular evolution of global DE genes was rapid, unlike that of changed-tissues DE genes. Based on gene ontology, global and changed-tissues DE genes were different, having no common GO terms. Expression differences of most global DE genes were regulated by cis-eQTLs. Expression

  19. Helping children express grief through symbolic communication.

    Science.gov (United States)

    Segal, R M

    1984-12-01

    Communication barriers erected by grieving children delay problem resolution. Use of the expressive arts--music, art, and body movement--in symbolic communication helps them to express overwhelming feelings and cope with trauma and stress.

  20. The College Student's Freedom of Expression

    Science.gov (United States)

    Gibbs, Annette

    1974-01-01

    Discussion of means to ensure freedom of expression by college students. Areas of expression noted are student newspapers, lectures by off-campus speakers, freedom to assemble peaceably and freedom to associate. (EK)

  1. Moxibustion upregulates hippocampal progranulin expression

    Directory of Open Access Journals (Sweden)

    Tao Yi

    2016-01-01

    Full Text Available In China, moxibustion is reported to be useful and has few side effects for chronic fatigue syndrome, but its mechanisms are largely unknown. More recently, the focus has been on the wealth of information supporting stress as a factor in chronic fatigue syndrome, and largely concerns dysregulation in the stress-related hypothalamic-pituitary-adrenal axis. In the present study, we aimed to determine the effect of moxibustion on behavioral symptoms in chronic fatigue syndrome rats and examine possible mechanisms. Rats were subjected to a combination of chronic restraint stress and forced swimming to induce chronic fatigue syndrome. The acupoints Guanyuan (CV4 and Zusanli (ST36, bilateral were simultaneously administered moxibustion. Untreated chronic fatigue syndrome rats and normal rats were used as controls. Results from the forced swimming test, open field test, tail suspension test, real-time PCR, enzyme-linked immunosorbent assay, and western blot assay showed that moxibustion treatment decreased mRNA expression of corticotropin-releasing hormone in the hypothalamus, and adrenocorticotropic hormone and corticosterone levels in plasma, and markedly increased progranulin mRNA and protein expression in the hippocampus. These findings suggest that moxibustion may relieve the behavioral symptoms of chronic fatigue syndrome, at least in part, by modulating the hypothalamic-pituitary-adrenal axis and upregulating hippocampal progranulin.

  2. Hepcidin expression in psoriasis patients

    Directory of Open Access Journals (Sweden)

    Nursel Dilek

    2014-01-01

    Full Text Available Background: Iron is an essential nutrient for mammals. Accelerated loss of nutrients through hyperproliferation and desquamation from the skin in psoriasis is known. Hepcidin is an important and recently discovered regulator of iron homeostasis. Aims and Objectives: The present study was undertaken to investigate the hepcidin expression in psoriasis patients. Materials and Methods: We examined peripheral blood cell counts, serum Fe, ferritin, interleukin-6 (IL-6 and hepcidin levels using respectively automated hematology analyzer, Iron assay on the AEROSET system, chemiluminescent microparticle immunoassay with automated analyzer, and enzyme-linked immunosorbent assay. Results: The independent comparison of Fe, ferritin, IL-6 and hepcidin levels in psoriasis patients and control group (healthy volunteers revealed lower Fe and higher IL-6, hepcidin levels in psoriasis patients. No significant difference was seen in the ferritin level between the psoriasis and the control group. Conclusions: We think that studies on hepcidin expression in psoriatic plaques will contribute to our understanding the role of iron and hepcidin in the pathogenesis of psoriasis.

  3. Edix: A Software for Editing Algebraic Expressions.

    OpenAIRE

    Bouhineau , Denis; Nicaud , Jean-François; Pavard , X.

    2001-01-01

    International audience; The paper presents a computer software, called Edix, devoted to the edition of algebraic expressions in their usual 2D representation. At present, many systems display fine algebraic expressions, but the edition of such expressions is weak. Systems like Word and FrameMaker place sub-expressions in too many boxes so that many editing actions are not simple, while usual CAS (computer algebra systems) just use a 1D representation for the edition. Furthermore, Edix allows ...

  4. Kivy and Langer on expressiveness in music

    Directory of Open Access Journals (Sweden)

    van der Schoot Albert

    2013-01-01

    Full Text Available From 1980 onwards, Peter Kivy has put forward that music does not so much express emotions but rather is expressive of emotions. The character of the music does not represent the character or mood of the composer, but reflects his knowledge of emotional life. Unfortunately, Kivy fails to give credit to Susanne Langer, who brought these views to the fore as early as 1942, claiming that the vitality of music lies in expressiveness, not in expression.

  5. The evolution of gene expression in primates

    OpenAIRE

    Tashakkori Ghanbarian, Avazeh

    2015-01-01

    The evolution of a gene’s expression profile is commonly assumed to be independent of its genomic neighborhood. This is, however, in contrast to what we know about the lack of autonomy between expression of neighboring genes in extant taxa. Indeed, in all eukaryotic genomes, genes of similar expression-profile tend to cluster, reflecting chromatin level dynamics. Does it follow that if a gene increases expression in a particular lineage then the genomic neighbors will also increase in their e...

  6. Intrahepatic expression of interferon alpha & interferon alpha ...

    African Journals Online (AJOL)

    kemrilib

    IFN-α and IFN-α Receptor mRNA expression in the liver. All the patients showed IFN-α gene expression except one patient who had the highest degree of fibrosis (fibrosis grade 5) and HAI Index of 9. IFN- α Receptor mRNA was expressed in 30% (9/30). (Figure 4). Non of the patients with HCC had. IFNα-Rc expression and ...

  7. Generating Expressive Speech for Storytelling Applications

    NARCIS (Netherlands)

    Bailly, G.; Theune, Mariet; Meijs, Koen; Campbell, N.; Hamza, W.; Heylen, Dirk K.J.; Ordelman, Roeland J.F.; Hoge, H.; Jianhua, T.

    Work on expressive speech synthesis has long focused on the expression of basic emotions. In recent years, however, interest in other expressive styles has been increasing. The research presented in this paper aims at the generation of a storytelling speaking style, which is suitable for

  8. 75 FR 473 - Community Express Pilot Program

    Science.gov (United States)

    2010-01-05

    ... SMALL BUSINESS ADMINISTRATION Community Express Pilot Program AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of extension of the Community Express Pilot Program. SUMMARY: This notice extends the Community Express Pilot Program in its current form through December 31, 2010. Based upon the...

  9. 75 FR 80561 - Community Express Pilot Program

    Science.gov (United States)

    2010-12-22

    ... SMALL BUSINESS ADMINISTRATION Community Express Pilot Program AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of short-term extension and termination of the Community Express Pilot Program. SUMMARY: This notice announces the termination of the Community Express Pilot Program following a...

  10. A constructive approach to gene expression dynamics

    International Nuclear Information System (INIS)

    Ochiai, T.; Nacher, J.C.; Akutsu, T.

    2004-01-01

    Recently, experiments on mRNA abundance (gene expression) have revealed that gene expression shows a stationary organization described by a scale-free distribution. Here we propose a constructive approach to gene expression dynamics which restores the scale-free exponent and describes the intermediate state dynamics. This approach requires only one assumption: Markov property

  11. Vocal Emotion Expressions Effects on Cooperation Behavior

    Science.gov (United States)

    Caballero Meneses, Jonathan Azael; Menez Díaz, Judith Marina

    2017-01-01

    Emotional expressions have been proposed to be important for regulating social interaction as they can serve as cues for behavioral intentions. The issue has been mainly addressed analyzing the effects of facial emotional expressions in cooperation behavior, but there are contradictory results regarding the impact of emotional expressions on that…

  12. Construction of expression vectors carrying mouse peroxisomal ...

    African Journals Online (AJOL)

    PRECIOUS

    2009-11-16

    Nov 16, 2009 ... The aim of this study was to construct expression vectors carrying mouse peroxisomal protein gene. (PEP-cDNA) in prokaryotic and mammalian expression vectors in chimeric cDNA types, encompassing. GST and FLAG with PEP-cDNA. PEP-cDNA was sub-cloned in pGEX6p2 prokaryotic expression ...

  13. Endogenous retrovirus sequences expressed in male mammalian ...

    African Journals Online (AJOL)

    In humans, one ERV family, human endogenous retrovirus- K (HERV-K) is abundantly expressed, and is associated with germ cell tumours, while ERV3 env is expressed in normal human testis. Conclusion: The expression of ERVs in male reproductive tissues suggests a possible role in normal and disease conditions ...

  14. Differentially expressed genes linked to natural variation in long-term memory formation in Cotesia parasitic wasps

    Directory of Open Access Journals (Sweden)

    Joke J. F. A. Van Vugt

    2015-09-01

    Full Text Available Even though learning and memory are universal traits in the Animal Kingdom, closely related species reveal substantial variation in learning rate and memory dynamics. To determine the genetic background of this natural variation, we studied two congeneric parasitic wasp species, Cotesia glomerata and C. rubecula, which lay their eggs in caterpillars of the large and small cabbage white butterfly. A successful egg laying event serves as an unconditioned stimulus in a classical conditioning paradigm, where plant odors become associated to the encounter of a suitable host caterpillar. Depending on the host species, the number of conditioning trials and the parasitic wasp species, three different types of transcription-dependent long-term memory (LTM and one type of transcription-independent, anesthesia-resistant memory (ARM can be distinguished. To identify transcripts underlying these differences in memory formation, we isolated mRNA from parasitic wasp heads at three different time points between induction and consolidation of each of the four memory types, and for each sample three biological replicates, where after strand-specific paired-end 100 bp deep sequencing. Transcriptomes were assembled de novo and differential expression was determined for each memory type and time point after conditioning, compared to unconditioned wasps. Most differentially expressed (DE genes and antisense transcripts were only DE in one of the LTM types. Among the DE genes that were DE in two or more LTM types, were many protein kinases and phosphatases, small GTPases, receptors and ion channels. Some genes were DE in opposing directions between any of the LTM memory types and ARM, suggesting that ARM in Cotesia requires the transcription of genes inhibiting LTM or vice versa. We discuss our findings in the context of neuronal functioning, including RNA splicing and transport, epigenetic regulation, neurotransmitter/peptide synthesis and antisense transcription. In

  15. Expressiveness modulo Bisimilarity of Regular Expressions with Parallel Composition (Extended Abstract

    Directory of Open Access Journals (Sweden)

    Jos C. M. Baeten

    2010-11-01

    Full Text Available The languages accepted by finite automata are precisely the languages denoted by regular expressions. In contrast, finite automata may exhibit behaviours that cannot be described by regular expressions up to bisimilarity. In this paper, we consider extensions of the theory of regular expressions with various forms of parallel composition and study the effect on expressiveness. First we prove that adding pure interleaving to the theory of regular expressions strictly increases its expressiveness up to bisimilarity. Then, we prove that replacing the operation for pure interleaving by ACP-style parallel composition gives a further increase in expressiveness. Finally, we prove that the theory of regular expressions with ACP-style parallel composition and encapsulation is expressive enough to express all finite automata up to bisimilarity. Our results extend the expressiveness results obtained by Bergstra, Bethke and Ponse for process algebras with (the binary variant of Kleene's star operation.

  16. 3 October 2013 - Ukrainian Vice Prime Minister Ukraine K. I. Gryschenko welcomed by CERN Director-General R. Heuer who introduces Head of International Relations R. Voss; Head of Technology Department F. Bordry; Deputy Head of International Relations E. Tsesmelis; Deputy Legal Counsel M. Wilbers; Adviser for Ukraine T. Kurtyka; Signing of the Agreement between Ukraine and CERN concerning the granting of the status of Associate Member at CERN; in the LHC tunnel at Point 5 and visiting CMS experimental area with CERN Team Leader A. Petrilli.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    3 October 2013 - Ukrainian Vice Prime Minister Ukraine K. I. Gryschenko welcomed by CERN Director-General R. Heuer who introduces Head of International Relations R. Voss; Head of Technology Department F. Bordry; Deputy Head of International Relations E. Tsesmelis; Deputy Legal Counsel M. Wilbers; Adviser for Ukraine T. Kurtyka; Signing of the Agreement between Ukraine and CERN concerning the granting of the status of Associate Member at CERN; in the LHC tunnel at Point 5 and visiting CMS experimental area with CERN Team Leader A. Petrilli.

  17. 20 fevrier 2012 - Le Vice-Président du Gouvernement Wallon et Ministre du Développement durable et de la Fonction Publique en charge de l’Energie du Logement et de la Recherche J.-M. Nollet, Royaume de Belgique, visite la salle de contrôle de CMS au Point 5, la caverne expérimentale CMS et le hall de tests des aimants supraconducteurs du LHC. Les chefs de département T. Lagrange et F. Hemmer accompagnent la délégation. L. Walckiers guide la visite SM18.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    20 fevrier 2012 - Le Vice-Président du Gouvernement Wallon et Ministre du Développement durable et de la Fonction Publique en charge de l’Energie du Logement et de la Recherche J.-M. Nollet, Royaume de Belgique, visite la salle de contrôle de CMS au Point 5, la caverne expérimentale CMS et le hall de tests des aimants supraconducteurs du LHC. Les chefs de département T. Lagrange et F. Hemmer accompagnent la délégation. L. Walckiers guide la visite SM18.

  18. Recognising and Interpreting Named Temporal Expressions

    DEFF Research Database (Denmark)

    Brucato, Matteo; Derczynski, Leon; Llorens, Hectjor

    2013-01-01

    This paper introduces a new class of temporal expression – named temporal expressions – and methods for recognising and interpreting its members. The commonest temporal expressions typically contain date and time words, like April or hours. Research into recognising and interpreting these typical...... expressions is mature in many languages. However, there is a class of expressions that are less typical, very varied, and difficult to automatically interpret. These indicate dates and times, but are harder to detect because they often do not contain time words and are not used frequently enough to appear...

  19. Synthetic promoter libraries- tuning of gene expression

    DEFF Research Database (Denmark)

    Hammer, Karin; Mijakovic, Ivan; Jensen, Peter Ruhdal

    2006-01-01

    knockout and strong overexpression. However, applications such as metabolic optimization and control analysis necessitate a continuous set of expression levels with only slight increments in strength to cover a specific window around the wildtype expression level of the studied gene; this requirement can......The study of gene function often requires changing the expression of a gene and evaluating the consequences. In principle, the expression of any given gene can be modulated in a quasi-continuum of discrete expression levels but the traditional approaches are usually limited to two extremes: gene...

  20. Expressing Model Constraints Visually with VMQL

    DEFF Research Database (Denmark)

    Störrle, Harald

    2011-01-01

    ) for specifying constraints on UML models. We examine VMQL's usability by controlled experiments and its expressiveness by a representative sample. We conclude that VMQL is less expressive than OCL, although expressive enough for most of the constraints in the sample. In terms of usability, however, VMQL......OCL is the de facto standard language for expressing constraints and queries on UML models. However, OCL expressions are very difficult to create, understand, and maintain, even with the sophisticated tool support now available. In this paper, we propose to use the Visual Model Query Language (VMQL...

  1. Abstract Expression Grammar Symbolic Regression

    Science.gov (United States)

    Korns, Michael F.

    This chapter examines the use of Abstract Expression Grammars to perform the entire Symbolic Regression process without the use of Genetic Programming per se. The techniques explored produce a symbolic regression engine which has absolutely no bloat, which allows total user control of the search space and output formulas, which is faster, and more accurate than the engines produced in our previous papers using Genetic Programming. The genome is an all vector structure with four chromosomes plus additional epigenetic and constraint vectors, allowing total user control of the search space and the final output formulas. A combination of specialized compiler techniques, genetic algorithms, particle swarm, aged layered populations, plus discrete and continuous differential evolution are used to produce an improved symbolic regression sytem. Nine base test cases, from the literature, are used to test the improvement in speed and accuracy. The improved results indicate that these techniques move us a big step closer toward future industrial strength symbolic regression systems.

  2. E-mail: Outlook Express

    Directory of Open Access Journals (Sweden)

    Zainul Bakri

    2012-10-01

    Full Text Available Salah satu layanan Internet yang sangat penting adalah electronic mail atau sering hanya disebut sebagai e-mail. Untuk menggunakan e-mail, diperlukan piranti lunak khusus supaya pengguna dapat mengirim dan menerima e-mail. Jenis piranti lunak e-mail diantaranya adalah Outlook Express yang merupakan satu paket yang didistribusikan bersama Internet Explorer versi 4. Piranti lunak ini dijalankan pada PC yang mempunyai sistem operasi Windows 95 atau 98. Jenis piranti lunak e-mail yang lain adalah Eudora, Pegasus dan sebagainya. Bahkan ada yang diintegrasikan dengan Web Browser (alat untuk menelusuri situs Web misalnya IE,dan Netscape.Sebagai layaknya pelayanan pos, maka setiap pengguna e-mail mempunyai alamat tertentu yang tidak mungkin dipunyai oleh pengguna lainnya diseluruh dunia. Untuk keperluan pendistribusian, maka e-mail mempunyai semacam kantor pos yang ditempatkan dalam sebuah komputer server (mail server atau sering disebut sebagai host. 

  3. Generalized Expression for Polarization Density

    International Nuclear Information System (INIS)

    Wang, Lu; Hahm, T.S.

    2009-01-01

    A general polarization density which consists of classical and neoclassical parts is systematically derived via modern gyrokinetics and bounce-kinetics by employing a phase-space Lagrangian Lie-transform perturbation method. The origins of polarization density are further elucidated. Extending the work on neoclassical polarization for long wavelength compared to ion banana width [M. N. Rosenbluth and F. L. Hinton, Phys. Rev. Lett. 80, 724 (1998)], an analytical formula for the generalized neoclassical polarization including both finite-banana-width (FBW) and finite-Larmor-radius (FLR) effects for arbitrary radial wavelength in comparison to banana width and gyroradius is derived. In additional to the contribution from trapped particles, the contribution of passing particles to the neoclassical polarization is also explicitly calculated. Our analytic expression agrees very well with the previous numerical results for a wide range of radial wavelength.

  4. Perceived intimacy of expressed emotion.

    Science.gov (United States)

    Howell, A; Conway, M

    1990-08-01

    Research on norms for emotional expression and self-disclosure provided the basis for two hypotheses concerning the perceived intimacy of emotional self-disclosure. The first hypothesis was that the perceived intimacy of negative emotional disclosure would be greater than that of positive emotional disclosure; the second was that disclosures of more intense emotional states would be perceived as more intimate than disclosures of less intense emotional states for both negative and positive disclosures. Both hypotheses received support when male students in Canada rated the perceived intimacy of self-disclosures that were equated for topic and that covered a comprehensive sample of emotions and a range of emotional intensities. The effects were observed across all the topics of disclosure examined.

  5. Podoplanin Expression in Canine Melanoma.

    Science.gov (United States)

    Ogasawara, Satoshi; Honma, Ryusuke; Kaneko, Mika K; Fujii, Yuki; Kagawa, Yumiko; Konnai, Satoru; Kato, Yukinari

    2016-12-01

    A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein, we investigated whether PMab-38 reacts with canine melanoma. PMab-38 reacted with 90% of melanoma cells (9/10 cases) using immunohistochemistry. Of interest, PMab-38 stained the lymphatic endothelial cells and cancer-associated fibroblasts in melanoma tissues, although it did not stain any lymphatic endothelial cells in normal tissues. PMab-38 could be useful for uncovering the function of PDPN in canine melanomas.

  6. Definition, Detection and Generation of Iyashi Expressions

    Science.gov (United States)

    Kitaoka, Tetsuko; Diago, Luis A.; Hagiwara, Ichiro; Kitazaki, Satoshi; Yamane, Shigeru

    This paper concerns the engineering analysis of “Iyashi”, a peculiar concept to the Japanese, which affect person's heart and may change their expression and behavior. We have integrated the advocator's view of “Iyashi”, analyzed the social background of “Iyashi” and have defined Iyashi and also the Iyashi expression. As the facial expression is the special and important stimulus for both observers and people who show expressions, we want to prove the existence of expressions that change the observer's emotion with Iyashi. We have developed the system to clarify the combination of facial features important for Iyashi through the psychological experiments and the analysis by Holographic Neural Networks (HNN). HNN analysis gave the structure of the Iyashi expression, that is the important combination of the physical facial parameters contributing to the high degree of Iyashi. Based on the structure of Iyashi we are able to generate the Iyashi expression appropriate for each person.

  7. Adaptive Evolution of Gene Expression in Drosophila

    Directory of Open Access Journals (Sweden)

    Armita Nourmohammad

    2017-08-01

    Full Text Available Gene expression levels are important quantitative traits that link genotypes to molecular functions and fitness. In Drosophila, population-genetic studies have revealed substantial adaptive evolution at the genomic level, but the evolutionary modes of gene expression remain controversial. Here, we present evidence that adaptation dominates the evolution of gene expression levels in flies. We show that 64% of the observed expression divergence across seven Drosophila species are adaptive changes driven by directional selection. Our results are derived from time-resolved data of gene expression divergence across a family of related species, using a probabilistic inference method for gene-specific selection. Adaptive gene expression is stronger in specific functional classes, including regulation, sensory perception, sexual behavior, and morphology. Moreover, we identify a large group of genes with sex-specific adaptation of expression, which predominantly occurs in males. Our analysis opens an avenue to map system-wide selection on molecular quantitative traits independently of their genetic basis.

  8. A Model-Based Joint Identification of Differentially Expressed Genes and Phenotype-Associated Genes.

    Directory of Open Access Journals (Sweden)

    Samuel Sunghwan Cho

    Full Text Available Over the last decade, many analytical methods and tools have been developed for microarray data. The detection of differentially expressed genes (DEGs among different treatment groups is often a primary purpose of microarray data analysis. In addition, association studies investigating the relationship between genes and a phenotype of interest such as survival time are also popular in microarray data analysis. Phenotype association analysis provides a list of phenotype-associated genes (PAGs. However, it is sometimes necessary to identify genes that are both DEGs and PAGs. We consider the joint identification of DEGs and PAGs in microarray data analyses. The first approach we used was a naïve approach that detects DEGs and PAGs separately and then identifies the genes in an intersection of the list of PAGs and DEGs. The second approach we considered was a hierarchical approach that detects DEGs first and then chooses PAGs from among the DEGs or vice versa. In this study, we propose a new model-based approach for the joint identification of DEGs and PAGs. Unlike the previous two-step approaches, the proposed method identifies genes simultaneously that are DEGs and PAGs. This method uses standard regression models but adopts different null hypothesis from ordinary regression models, which allows us to perform joint identification in one-step. The proposed model-based methods were evaluated using experimental data and simulation studies. The proposed methods were used to analyze a microarray experiment in which the main interest lies in detecting genes that are both DEGs and PAGs, where DEGs are identified between two diet groups and PAGs are associated with four phenotypes reflecting the expression of leptin, adiponectin, insulin-like growth factor 1, and insulin. Model-based approaches provided a larger number of genes, which are both DEGs and PAGs, than other methods. Simulation studies showed that they have more power than other methods

  9. A Model-Based Joint Identification of Differentially Expressed Genes and Phenotype-Associated Genes

    Science.gov (United States)

    Seo, Minseok; Shin, Su-kyung; Kwon, Eun-Young; Kim, Sung-Eun; Bae, Yun-Jung; Lee, Seungyeoun; Sung, Mi-Kyung; Choi, Myung-Sook; Park, Taesung

    2016-01-01

    Over the last decade, many analytical methods and tools have been developed for microarray data. The detection of differentially expressed genes (DEGs) among different treatment groups is often a primary purpose of microarray data analysis. In addition, association studies investigating the relationship between genes and a phenotype of interest such as survival time are also popular in microarray data analysis. Phenotype association analysis provides a list of phenotype-associated genes (PAGs). However, it is sometimes necessary to identify genes that are both DEGs and PAGs. We consider the joint identification of DEGs and PAGs in microarray data analyses. The first approach we used was a naïve approach that detects DEGs and PAGs separately and then identifies the genes in an intersection of the list of PAGs and DEGs. The second approach we considered was a hierarchical approach that detects DEGs first and then chooses PAGs from among the DEGs or vice versa. In this study, we propose a new model-based approach for the joint identification of DEGs and PAGs. Unlike the previous two-step approaches, the proposed method identifies genes simultaneously that are DEGs and PAGs. This method uses standard regression models but adopts different null hypothesis from ordinary regression models, which allows us to perform joint identification in one-step. The proposed model-based methods were evaluated using experimental data and simulation studies. The proposed methods were used to analyze a microarray experiment in which the main interest lies in detecting genes that are both DEGs and PAGs, where DEGs are identified between two diet groups and PAGs are associated with four phenotypes reflecting the expression of leptin, adiponectin, insulin-like growth factor 1, and insulin. Model-based approaches provided a larger number of genes, which are both DEGs and PAGs, than other methods. Simulation studies showed that they have more power than other methods. Through analysis of

  10. Anticausatives are weak scalar expressions, not reflexive expressions

    Directory of Open Access Journals (Sweden)

    Florian Schäfer

    2016-07-01

    Full Text Available We discuss conceptual and empirical arguments from Germanic, Romance and Slavic languages against an analysis treating anticausative verbs as derived from their lexical causative counterparts under reflexivization. Instead, we defend the standard account to the semantics of the causative alternation according to which anticausatives in general, and anticausatives marked with reflexive morphology in particular, denote simple one-place inchoative events that are logically entailed by their lexical causative counterparts. Under such an account, anticausative verbs are weak scalar expressions that stand in a semantico-pragmatic opposition to their strong lexical causative counterparts. Due to this scalar relation, the use of an anticausative can trigger the implicature that the use of its lexical causative counterpart is too strong. As usual with implicatures, they can be ‘metalinguistically’ denied, cancelled, or reinforced and we argue that these mechanisms explain all central empirical facts brought up in the literature in favor of a treatment of anticausatives as semantically reflexive predicates. Our results reinforce the view that the reflexive morphemes used in many (Indo-European languages to mark anticausatives do not necessarily trigger reflexive semantics. However, we also show that a string involving a reflexively marked (anti-causative verb can be forced into a semantically reflexive construal under particular conceptual or grammatical circumstances.

  11. Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumours

    DEFF Research Database (Denmark)

    Wang, Jinmei; Wu, Yazhen; Heegaard, Steffen

    2011-01-01

    Purpose: Cyclooxygenase-2 (COX-2) is an enzyme involved in neoplastic processes. The purpose of the present study is to investigate COX-2 expression in the normal human eye and the expression pattern in selected eye tumours involving COX-2 expressing cells. Methods: Immunohistochemical staining...... using antibodies against COX-2 was performed on paraffin sections of normal human eyes and selected eye tumours arising from cells expressing COX-2. Results: Cyclooxygenase-2 expression was found in various structures of the normal eye. Abundant expression was seen in the cornea, iris, ciliary body...... and retina. The COX-2 expression was less in tumours deriving from the ciliary epithelium and also in retinoblastoma. Conclusion: Cyclooxygenase-2 is constitutively expressed in normal human eyes. The expression of COX-2 is much lower in selected eye tumours involving COX-2 expressing cells....

  12. The law for the Japan Atomic Energy Research Institute

    International Nuclear Information System (INIS)

    1977-01-01

    The law establishes the Japan Atomic Energy Research Institute in accordance with the Basic Act on Atomic Energy as a government corporation for the purpose of promoting R and D and utilizations of atomic energy (first chapter). The second chapter concerns the directors, advisers and personnel of the institute, namely a chairman of the board of directors, a vice-chairman, directors not more than seven persons, and auditors not more than two persons. The chairman represents and supervises the intitute, whom the prime minister appoints with the agreement of Atomic Energy Commission. The vice-chairman and other directors are nominated by the chairman with the approval of the prime minister, while the auditors are appointed by the prime minister with the advice of the Atomic Energy Commission. Their terms of office are 4 years for directors and 2 years for auditors. The third chapter defines the scope of activities of the institute as follows: basic and applied researches on atomic energy; design, construction and operation of nuclear reactors; training of researchers and technicians; and import, production and distribution of radioisotopes. Those activities should be done in accordance with the basic development and utilization plans of atomic energy established by the prime minister with the determination of Atomic Energy Commission. The fourth chapter provides for the finance and accounting of the institute, and the fifth chapter requires the supervision of the institute by the prime minister. (Matsushima, A.)

  13. Facial expressions and pair bonds in hylobatids.

    Science.gov (United States)

    Florkiewicz, Brittany; Skollar, Gabriella; Reichard, Ulrich H

    2018-06-06

    Facial expressions are an important component of primate communication that functions to transmit social information and modulate intentions and motivations. Chimpanzees and macaques, for example, produce a variety of facial expressions when communicating with conspecifics. Hylobatids also produce various facial expressions; however, the origin and function of these facial expressions are still largely unclear. It has been suggested that larger facial expression repertoires may have evolved in the context of social complexity, but this link has yet to be tested at a broader empirical basis. The social complexity hypothesis offers a possible explanation for the evolution of complex communicative signals such as facial expressions, because as the complexity of an individual's social environment increases so does the need for communicative signals. We used an intraspecies, pair-focused study design to test the link between facial expressions and sociality within hylobatids, specifically the strength of pair-bonds. The current study compared 206 hr of video and 103 hr of focal animal data for ten hylobatid pairs from three genera (Nomascus, Hoolock, and Hylobates) living at the Gibbon Conservation Center. Using video footage, we explored 5,969 facial expressions along three dimensions: repertoire use, repertoire breadth, and facial expression synchrony [FES]. We then used focal animal data to compare dimensions of facial expressiveness to pair bond strength and behavioral synchrony. Hylobatids in our study overlapped in only half of their facial expressions (50%) with the only other detailed, quantitative study of hylobatid facial expressions, while 27 facial expressions were uniquely observed in our study animals. Taken together, hylobatids have a large facial expression repertoire of at least 80 unique facial expressions. Contrary to our prediction, facial repertoire composition was not significantly correlated with pair bond strength, rates of territorial synchrony

  14. Expressiveness in musical performance: Pedagogic aspect

    Directory of Open Access Journals (Sweden)

    Jović Natalija R.

    2016-01-01

    Full Text Available The subject of our research relates to pedagogic aspects of expressive vocal-instrumental musical performance. We intended to examine: (1 how undergraduate students see/conceptualize and evaluate expressiveness in musical performance; (2 whether and how they were trained in the skill of expressive musical performance during their musical training; (3 whether and in which way they rehearse the expressive component of musical performance and interpretation and (4 whether there are any differences regarding gender, age, instrument, department, year of study and years of instrument playing in relation to the group of dependant variables related to expressiveness, tuition and practice. The sample for the research included 82 students of instrumental and theory departments at the Faculty of Music in Belgrade. Psychological and pedagogical aspects of musical expressiveness during vocal-instrumental performance were analyzed. The results show that students highly evaluate expressiveness but its place is secondary compared to mastering technical and tonal requirements. Statistically significant differences were shown regarding gender, age and departments. It can be concluded that there is a potential for the development and enhancement of expressiveness of students if we abandon the traditional view that expressiveness is linked exclusively to talent. The findings indicate that pedagogical work should be directed towards finding purposeful strategies for training individual expressiveness.

  15. Widespread ectopic expression of olfactory receptor genes

    Directory of Open Access Journals (Sweden)

    Yanai Itai

    2006-05-01

    Full Text Available Abstract Background Olfactory receptors (ORs are the largest gene family in the human genome. Although they are expected to be expressed specifically in olfactory tissues, some ectopic expression has been reported, with special emphasis on sperm and testis. The present study systematically explores the expression patterns of OR genes in a large number of tissues and assesses the potential functional implication of such ectopic expression. Results We analyzed the expression of hundreds of human and mouse OR transcripts, via EST and microarray data, in several dozens of human and mouse tissues. Different tissues had specific, relatively small OR gene subsets which had particularly high expression levels. In testis, average expression was not particularly high, and very few highly expressed genes were found, none corresponding to ORs previously implicated in sperm chemotaxis. Higher expression levels were more common for genes with a non-OR genomic neighbor. Importantly, no correlation in expression levels was detected for human-mouse orthologous pairs. Also, no significant difference in expression levels was seen between intact and pseudogenized ORs, except for the pseudogenes of subfamily 7E which has undergone a human-specific expansion. Conclusion The OR superfamily as a whole, show widespread, locus-dependent and heterogeneous expression, in agreement with a neutral or near neutral evolutionary model for transcription control. These results cannot reject the possibility that small OR subsets might play functional roles in different tissues, however considerable care should be exerted when offering a functional interpretation for ectopic OR expression based only on transcription information.

  16. Platelet cyclooxygenase expression in normal dogs.

    Science.gov (United States)

    Thomason, J; Lunsford, K; Mullins, K; Stokes, J; Pinchuk, L; Wills, R; McLaughlin, R; Langston, C; Pruett, S; Mackin, A

    2011-01-01

    Human platelets express both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Variation in COX-2 expression could be a mechanism for variable response to aspirin. The hypotheses were that circulating canine platelets express COX-1 and COX-2, and that aspirin alters COX expression. The objective was to identify changes in platelet COX expression and in platelet function caused by aspirin administration to dogs. Eight female, intact hounds. A single population, repeated measures design was used to evaluate platelet COX-1 and COX-2 expression by flow cytometry before and after aspirin (10 mg/kg Q12h for 10 days). Platelet function was analyzed via PFA-100(®) (collagen/epinephrine), and urine 11-dehydro-thromboxane B(2) (11-dTXB(2)) was measured and normalized to urinary creatinine. Differences in COX expression, PFA-100(®) closure times, and urine 11-dTXB(2 ): creatinine ratio were analyzed before and after aspirin administration. Both COX-1 and COX-2 were expressed in canine platelets. COX-1 mean fluorescent intensity (MFI) increased in all dogs, by 250% (range 63-476%), while COX-2 expression did not change significantly (P = 0.124) after aspirin exposure, with large interindividual variation. PFA-100(®) closure times were prolonged and urine 11-dTXB(2) concentration decreased in all dogs after aspirin administration. Canine platelets express both COX isoforms. After aspirin exposure, COX-1 expression increased despite impairment of platelet function, while COX-2 expression varied markedly among dogs. Variability in platelet COX-2 expression should be explored as a potential mechanism for, or marker of, variable aspirin responsiveness. Copyright © 2011 by the American College of Veterinary Internal Medicine.

  17. Expressiveness and definability in circumscription

    Directory of Open Access Journals (Sweden)

    Francicleber Martins Ferreira

    2011-06-01

    Full Text Available We investigate expressiveness and definability issues with respect to minimal models, particularly in the scope of Circumscription. First, we give a proof of the failure of the Löwenheim-Skolem Theorem for Circumscription. Then we show that, if the class of P; Z-minimal models of a first-order sentence is Δ-elementary, then it is elementary. That is, whenever the circumscription of a first-order sentence is equivalent to a first-order theory, then it is equivalent to a finitely axiomatizable one. This means that classes of models of circumscribed theories are either elementary or not Δ-elementary. Finally, using the previous result, we prove that, whenever a relation Pi is defined in the class of P; Z-minimal models of a first-order sentence Φ and whenever such class of P; Z-minimal models is Δ-elementary, then there is an explicit definition ψ for Pi such that the class of P; Z-minimal models of Φ is the class of models of Φ ∧ ψ. In order words, the circumscription of P in Φ with Z varied can be replaced by Φ plus this explicit definition ψ for Pi.

  18. Adipocyte differentiation and leptin expression

    DEFF Research Database (Denmark)

    Hwang, C S; Loftus, T M; Mandrup, S

    1997-01-01

    Adipose tissue has long been known to house the largest energy reserves in the animal body. Recent research indicates that in addition to this role, the adipocyte functions as a global regulator of energy metabolism. Adipose tissue is exquisitely sensitive to a variety of endocrine and paracrine ...... of energy intake and expenditure. The hormonal and transcriptional control of adipocyte differentiation is discussed, as is the role of leptin and other factors secreted by the adipocyte that participate in the regulation of adipose homeostasis.......Adipose tissue has long been known to house the largest energy reserves in the animal body. Recent research indicates that in addition to this role, the adipocyte functions as a global regulator of energy metabolism. Adipose tissue is exquisitely sensitive to a variety of endocrine and paracrine......, most notably those of the C/EBP and PPAR families, which combine to regulate each other and to control the expression of adipocyte-specific genes. One such gene, i.e. the obese gene, was recently identified and found to encode a hormone, referred to as leptin, that plays a major role in the regulation...

  19. Recognizing Facial Expressions Automatically from Video

    Science.gov (United States)

    Shan, Caifeng; Braspenning, Ralph

    Facial expressions, resulting from movements of the facial muscles, are the face changes in response to a person's internal emotional states, intentions, or social communications. There is a considerable history associated with the study on facial expressions. Darwin [22] was the first to describe in details the specific facial expressions associated with emotions in animals and humans, who argued that all mammals show emotions reliably in their faces. Since that, facial expression analysis has been a area of great research interest for behavioral scientists [27]. Psychological studies [48, 3] suggest that facial expressions, as the main mode for nonverbal communication, play a vital role in human face-to-face communication. For illustration, we show some examples of facial expressions in Fig. 1.

  20. Stochastic gene expression in Arabidopsis thaliana.

    Science.gov (United States)

    Araújo, Ilka Schultheiß; Pietsch, Jessica Magdalena; Keizer, Emma Mathilde; Greese, Bettina; Balkunde, Rachappa; Fleck, Christian; Hülskamp, Martin

    2017-12-14

    Although plant development is highly reproducible, some stochasticity exists. This developmental stochasticity may be caused by noisy gene expression. Here we analyze the fluctuation of protein expression in Arabidopsis thaliana. Using the photoconvertible KikGR marker, we show that the protein expressions of individual cells fluctuate over time. A dual reporter system was used to study extrinsic and intrinsic noise of marker gene expression. We report that extrinsic noise is higher than intrinsic noise and that extrinsic noise in stomata is clearly lower in comparison to several other tissues/cell types. Finally, we show that cells are coupled with respect to stochastic protein expression in young leaves, hypocotyls and roots but not in mature leaves. Our data indicate that stochasticity of gene expression can vary between tissues/cell types and that it can be coupled in a non-cell-autonomous manner.

  1. Osteopontin expression in salivary gland carcinomas

    DEFF Research Database (Denmark)

    Bjørndal, Kristine; Larsen, Stine R; Godballe, Christian

    2011-01-01

    J Oral Pathol Med (2010) Background:  In several cancer types, osteopontin (OPN) expression has been correlated with tumor progression and prognosis. Two earlier studies have examined OPN expression in salivary gland carcinomas with contradictory results. Methods:  One hundred and seventy......:  Osteopontin was expressed in all salivary gland carcinomas. Adenoid cystic carcinomas had the highest mean sum score (7.3) and a significantly higher proportion of carcinomas with high OPN sum score than both mucoepidermoid carcinoma and acinic cell carcinoma. Correlation of OPN expression with known...... prognostic factors in salivary gland carcinomas was insignificant. Conclusions:  Salivary gland carcinomas express OPN. The expression does not correlate with known prognostic factors....

  2. "Express yourself": culture and the effect of self-expression on choice.

    Science.gov (United States)

    Kim, Heejung S; Sherman, David K

    2007-01-01

    Whereas self-expression is valued in the United States, it is not privileged with such a cultural emphasis in East Asia. Four studies demonstrate the psychological implications of this cultural difference. Studies 1 and 2 found that European Americans value self-expression more than East Asians/East Asian Americans. Studies 3 and 4 examined the roles of expression in preference judgments. In Study 3, the expression of choice led European Americans but not East Asian Americans to be more invested in what they chose. Study 4 examined the connection between the value of expression and the effect of choice expression and showed that European Americans place greater emphasis on self-expression than East Asian Americans, and this difference explained the cultural difference in Study 3. This research highlights the importance of the cultural meanings of self-expression and the moderating role of cultural beliefs on the psychological effect of self-expression. 2007 APA, all rights reserved

  3. Generating Expressive Speech for Storytelling Applications

    OpenAIRE

    Bailly, G.; Theune, Mariet; Meijs, Koen; Campbell, N.; Hamza, W.; Heylen, Dirk K.J.; Ordelman, Roeland J.F.; Hoge, H.; Jianhua, T.

    2006-01-01

    Work on expressive speech synthesis has long focused on the expression of basic emotions. In recent years, however, interest in other expressive styles has been increasing. The research presented in this paper aims at the generation of a storytelling speaking style, which is suitable for storytelling applications and more in general, for applications aimed at children. Based on an analysis of human storytellers' speech, we designed and implemented a set of prosodic rules for converting "neutr...

  4. Willingness to Express Emotions to Caregiving Spouses

    OpenAIRE

    Monin, Joan K.; Martire, Lynn M.; Schulz, Richard; Clark, Margaret S.

    2009-01-01

    This study examined the association between care-recipients’ willingness to express emotions to spousal caregivers and caregiver’s well-being and support behaviors. Using self-report measures in the context of a larger study, 262 care-recipients with osteoarthritis reported on their willingness to express emotions to caregivers, and caregivers reported on their stress and insensitive responding to care-recipients. Results revealed that care-recipients’ willingness to express happiness was ass...

  5. Comparative gene expression between two yeast species

    Directory of Open Access Journals (Sweden)

    Guan Yuanfang

    2013-01-01

    Full Text Available Abstract Background Comparative genomics brings insight into sequence evolution, but even more may be learned by coupling sequence analyses with experimental tests of gene function and regulation. However, the reliability of such comparisons is often limited by biased sampling of expression conditions and incomplete knowledge of gene functions across species. To address these challenges, we previously systematically generated expression profiles in Saccharomyces bayanus to maximize functional coverage as compared to an existing Saccharomyces cerevisiae data repository. Results In this paper, we take advantage of these two data repositories to compare patterns of ortholog expression in a wide variety of conditions. First, we developed a scalable metric for expression divergence that enabled us to detect a significant correlation between sequence and expression conservation on the global level, which previous smaller-scale expression studies failed to detect. Despite this global conservation trend, between-species gene expression neighborhoods were less well-conserved than within-species comparisons across different environmental perturbations, and approximately 4% of orthologs exhibited a significant change in co-expression partners. Furthermore, our analysis of matched perturbations collected in both species (such as diauxic shift and cell cycle synchrony demonstrated that approximately a quarter of orthologs exhibit condition-specific expression pattern differences. Conclusions Taken together, these analyses provide a global view of gene expression patterns between two species, both in terms of the conditions and timing of a gene's expression as well as co-expression partners. Our results provide testable hypotheses that will direct future experiments to determine how these changes may be specified in the genome.

  6. Structural development of child's artistic expression

    OpenAIRE

    Sanja Filipović; Milica Vojvodić

    2017-01-01

    Abstract Structural development implies control and capability of the expression usage in terms of independent creative expression and making. Understanding of structural development of child's artistic expression as a phenomenon (which is suitable to child's age) has some implications on methodical acts considering artistic education of children and youngsters. Therefore, it is of unexceptional importance to know these laws as well as methodical acts which encourage the structural develop...

  7. Methods for monitoring multiple gene expression

    Energy Technology Data Exchange (ETDEWEB)

    Berka, Randy [Davis, CA; Bachkirova, Elena [Davis, CA; Rey, Michael [Davis, CA

    2012-05-01

    The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.

  8. Methods for monitoring multiple gene expression

    Energy Technology Data Exchange (ETDEWEB)

    Berka, Randy; Bachkirova, Elena; Rey, Michael

    2013-10-01

    The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.

  9. Identification of Emotional Facial Expressions: Effects of Expression, Intensity, and Sex on Eye Gaze.

    Directory of Open Access Journals (Sweden)

    Laura Jean Wells

    Full Text Available The identification of emotional expressions is vital for social interaction, and can be affected by various factors, including the expressed emotion, the intensity of the expression, the sex of the face, and the gender of the observer. This study investigates how these factors affect the speed and accuracy of expression recognition, as well as dwell time on the two most significant areas of the face: the eyes and the mouth. Participants were asked to identify expressions from female and male faces displaying six expressions (anger, disgust, fear, happiness, sadness, and surprise, each with three levels of intensity (low, moderate, and normal. Overall, responses were fastest and most accurate for happy expressions, but slowest and least accurate for fearful expressions. More intense expressions were also classified most accurately. Reaction time showed a different pattern, with slowest response times recorded for expressions of moderate intensity. Overall, responses were slowest, but also most accurate, for female faces. Relative to male observers, women showed greater accuracy and speed when recognizing female expressions. Dwell time analyses revealed that attention to the eyes was about three times greater than on the mouth, with fearful eyes in particular attracting longer dwell times. The mouth region was attended to the most for fearful, angry, and disgusted expressions and least for surprise. These results extend upon previous findings to show important effects of expression, emotion intensity, and sex on expression recognition and gaze behaviour, and may have implications for understanding the ways in which emotion recognition abilities break down.

  10. Identification of Emotional Facial Expressions: Effects of Expression, Intensity, and Sex on Eye Gaze.

    Science.gov (United States)

    Wells, Laura Jean; Gillespie, Steven Mark; Rotshtein, Pia

    2016-01-01

    The identification of emotional expressions is vital for social interaction, and can be affected by various factors, including the expressed emotion, the intensity of the expression, the sex of the face, and the gender of the observer. This study investigates how these factors affect the speed and accuracy of expression recognition, as well as dwell time on the two most significant areas of the face: the eyes and the mouth. Participants were asked to identify expressions from female and male faces displaying six expressions (anger, disgust, fear, happiness, sadness, and surprise), each with three levels of intensity (low, moderate, and normal). Overall, responses were fastest and most accurate for happy expressions, but slowest and least accurate for fearful expressions. More intense expressions were also classified most accurately. Reaction time showed a different pattern, with slowest response times recorded for expressions of moderate intensity. Overall, responses were slowest, but also most accurate, for female faces. Relative to male observers, women showed greater accuracy and speed when recognizing female expressions. Dwell time analyses revealed that attention to the eyes was about three times greater than on the mouth, with fearful eyes in particular attracting longer dwell times. The mouth region was attended to the most for fearful, angry, and disgusted expressions and least for surprise. These results extend upon previous findings to show important effects of expression, emotion intensity, and sex on expression recognition and gaze behaviour, and may have implications for understanding the ways in which emotion recognition abilities break down.

  11. Growth, nisA Gene Expression, and In Situ Activity of Novel Lactococcus lactis subsp. cremoris Costarter Culture in Commercial Hard Cheese Production.

    Science.gov (United States)

    Noutsopoulos, Dimitrios; Kakouri, Athanasia; Kartezini, Eleftheria; Pappas, Dimitrios; Hatziloukas, Efstathios; Samelis, John

    2017-12-01

    This study evaluated in situ expression of the nisA gene by an indigenous, nisin A-producing (NisA+) Lactococcus lactis subsp. cremoris raw milk genotype, represented by strain M78, in traditional Greek Graviera cheeses under real factory-scale manufacturing and ripening conditions. Cheeses were produced with added a mixed thermophilic and mesophilic commercial starter culture (CSC) or with the CSC plus strain M78 (CSC+M78). Cheeses were sampled after curd cooking (day 0), fermentation of the unsalted molds for 24 h (day 1), brining (day 7), and ripening of the brined molds (14 to 15 kg each) for 30 days in a fully controlled industrial room (16.5°C; 91% relative humidity; day 37). Total RNA was directly extracted from the cheese samples, and the expression of nisA gene was evaluated by real-time reverse transcription PCR (qRT-PCR). Agar overlay and well diffusion bioassays were correspondingly used for in situ detection of the M78 NisA+ colonies in the cheese agar plates and antilisterial activity in whole-cheese slurry samples, respectively. Agar overlay assays showed good growth (>8 log CFU/g of cheese) of the NisA+ strain M78 in coculture with the CSC and vice versa. The nisA expression was detected in CSC+M78 cheese samples only, with its expression levels being the highest (16-fold increase compared with those of the control gene) on day 1, followed by significant reduction on day 7 and almost negligible expression on day 37. Based on the results, certain intrinsic and mainly implicit hurdle factors appeared to reduce growth prevalence rates and decrease nisA gene expression, as well as the nisin A-mediated antilisterial activities of the NisA+ strain M78 postfermentation. To our knowledge, this is the first report on quantitative expression of the nisA gene in a Greek cooked hard cheese during commercial manufacturing and ripening conditions by using a novel, rarely isolated, indigenous NisA+ L. lactis subsp. cremoris genotype as costarter culture.

  12. Profiling Gene Expression in Germinating Brassica Roots.

    Science.gov (United States)

    Park, Myoung Ryoul; Wang, Yi-Hong; Hasenstein, Karl H

    2014-01-01

    Based on previously developed solid-phase gene extraction (SPGE) we examined the mRNA profile in primary roots of Brassica rapa seedlings for highly expressed genes like ACT7 (actin7), TUB (tubulin1), UBQ (ubiquitin), and low expressed GLK (glucokinase) during the first day post-germination. The assessment was based on the mRNA load of the SPGE probe of about 2.1 ng. The number of copies of the investigated genes changed spatially along the length of primary roots. The expression level of all genes differed significantly at each sample position. Among the examined genes ACT7 expression was most even along the root. UBQ was highest at the tip and root-shoot junction (RS). TUB and GLK showed a basipetal gradient. The temporal expression of UBQ was highest in the MZ 9 h after primary root emergence and higher than at any other sample position. Expressions of GLK in EZ and RS increased gradually over time. SPGE extraction is the result of oligo-dT and oligo-dA hybridization and the results illustrate that SPGE can be used for gene expression profiling at high spatial and temporal resolution. SPGE needles can be used within two weeks when stored at 4 °C. Our data indicate that gene expression studies that are based on the entire root miss important differences in gene expression that SPGE is able to resolve for example growth adjustments during gravitropism.

  13. TRPM4 protein expression in prostate cancer

    DEFF Research Database (Denmark)

    Berg, Kasper Drimer; Soldini, Davide; Jung, Maria

    2016-01-01

    BACKGROUND: Transient receptor potential cation channel, subfamily M, member 4 (TRPM4) messenger RNA (mRNA) has been shown to be upregulated in prostate cancer (PCa) and might be a new promising tissue biomarker. We evaluated TRPM4 protein expression and correlated the expression level.......79-2.62; p = 0.01-0.03 for the two observers) when compared to patients with a lower staining intensity. CONCLUSIONS: TRPM4 protein expression is widely expressed in benign and cancerous prostate tissue, with highest staining intensities found in PCa. Overexpression of TRPM4 in PCa (combination of high...

  14. Automatic emotional expression analysis from eye area

    Science.gov (United States)

    Akkoç, Betül; Arslan, Ahmet

    2015-02-01

    Eyes play an important role in expressing emotions in nonverbal communication. In the present study, emotional expression classification was performed based on the features that were automatically extracted from the eye area. Fırst, the face area and the eye area were automatically extracted from the captured image. Afterwards, the parameters to be used for the analysis through discrete wavelet transformation were obtained from the eye area. Using these parameters, emotional expression analysis was performed through artificial intelligence techniques. As the result of the experimental studies, 6 universal emotions consisting of expressions of happiness, sadness, surprise, disgust, anger and fear were classified at a success rate of 84% using artificial neural networks.

  15. Modulation of gene expression made easy

    DEFF Research Database (Denmark)

    Solem, Christian; Jensen, Peter Ruhdal

    2002-01-01

    A new approach for modulating gene expression, based on randomization of promoter (spacer) sequences, was developed. The method was applied to chromosomal genes in Lactococcus lactis and shown to generate libraries of clones with broad ranges of expression levels of target genes. In one example...... that the method can be applied to modulating the expression of native genes on the chromosome. We constructed a series of strains in which the expression of the las operon, containing the genes pfk, pyk, and ldh, was modulated by integrating a truncated copy of the pfk gene. Importantly, the modulation affected...

  16. Judgments of subtle facial expressions of emotion.

    Science.gov (United States)

    Matsumoto, David; Hwang, Hyisung C

    2014-04-01

    Most studies on judgments of facial expressions of emotion have primarily utilized prototypical, high-intensity expressions. This paper examines judgments of subtle facial expressions of emotion, including not only low-intensity versions of full-face prototypes but also variants of those prototypes. A dynamic paradigm was used in which observers were shown a neutral expression followed by the target expression to judge, and then the neutral expression again, allowing for a simulation of the emergence of the expression from and then return to a baseline. We also examined how signal and intensity clarities of the expressions (explained more fully in the Introduction) were associated with judgment agreement levels. Low-intensity, full-face prototypical expressions of emotion were judged as the intended emotion at rates significantly greater than chance. A number of the proposed variants were also judged as the intended emotions. Both signal and intensity clarities were individually associated with agreement rates; when their interrelationships were taken into account, signal clarity independently predicted agreement rates but intensity clarity did not. The presence or absence of specific muscles appeared to be more important to agreement rates than their intensity levels, with the exception of the intensity of zygomatic major, which was positively correlated with agreement rates for judgments of joy.

  17. Examining emotional expressions in discourse: methodological considerations

    Science.gov (United States)

    Hufnagel, Elizabeth; Kelly, Gregory J.

    2017-10-01

    This methodological paper presents an approach for examining emotional expressions through discourse analysis and ethnographic methods. Drawing on trends in the current literature in science education, we briefly explain the importance of emotions in science education and examine the current research methodologies used in interactional emotion studies. We put forth and substantiate a methodological approach that attends to the interactional, contextual, intertextual, and consequential aspects of emotional expressions. By examining emotional expressions in the discourse in which they are constructed, emotional expressions are identified through semantics, contextualization, and linguistic features. These features make salient four dimensions of emotional expressions: aboutness, frequency, type, and ownership. Drawing on data from a large empirical study of pre-service elementary teachers' emotional expressions about climate change in a science course, we provide illustrative examples to describe what counts as emotional expressions in situ. In doing so we explain how our approach makes salient the nuanced nature of such expressions as well as the broader discourse in which they are constructed and the implications for researching emotional expressions in science education discourse. We suggest reasons why this discourse orientated research methodology can contribute to the interactional study of emotions in science education contexts.

  18. Social Use of Facial Expressions in Hylobatids

    Science.gov (United States)

    Scheider, Linda; Waller, Bridget M.; Oña, Leonardo; Burrows, Anne M.; Liebal, Katja

    2016-01-01

    Non-human primates use various communicative means in interactions with others. While primate gestures are commonly considered to be intentionally and flexibly used signals, facial expressions are often referred to as inflexible, automatic expressions of affective internal states. To explore whether and how non-human primates use facial expressions in specific communicative interactions, we studied five species of small apes (gibbons) by employing a newly established Facial Action Coding System for hylobatid species (GibbonFACS). We found that, despite individuals often being in close proximity to each other, in social (as opposed to non-social contexts) the duration of facial expressions was significantly longer when gibbons were facing another individual compared to non-facing situations. Social contexts included grooming, agonistic interactions and play, whereas non-social contexts included resting and self-grooming. Additionally, gibbons used facial expressions while facing another individual more often in social contexts than non-social contexts where facial expressions were produced regardless of the attentional state of the partner. Also, facial expressions were more likely ‘responded to’ by the partner’s facial expressions when facing another individual than non-facing. Taken together, our results indicate that gibbons use their facial expressions differentially depending on the social context and are able to use them in a directed way in communicative interactions with other conspecifics. PMID:26978660

  19. Clusterin expression in elastofibroma dorsi.

    Science.gov (United States)

    Aigelsreiter, Ariane; Pichler, Martin; Pixner, Thomas; Janig, Elke; Schuller, Monika; Lackner, Carolin; Scheipl, Susanne; Beham, Alfred; Regauer, Sigrid

    2013-05-01

    Elastofibroma dorsi is a benign soft tissue lesion composed of abnormal elastic fibers. Degenerated elastic fibers in skin and liver are associated with clusterin, an apoprotein that shares functional properties with small heat shock proteins. We evaluated the staining pattern and possible role of clusterin in elastofibroma dorsi. Twenty-one subcutaneous elastofibromas from the scapular region were evaluated with Elastica van Gieson and Orcein stains, immunohistochemically with antibodies to clusterin, smooth muscle actin, S-100, vimentin and CD34 and correlated with clinical data with respect to physical trauma. Clusterin correlated with the staining pattern of Elastica van Gieson and labelled abnormal broad coarse fibrillar and globular elastic fibers in all elastofibromas. Orcein stains additionally identified fine oxytalan fibers which were not stained by clusterin. Clusterin staining was observed only on the outside of the elastin fibers, while the cores of fibers and globules were unstained. 4/21 elastofibromas showed cellular nodules with a myxoid/collagenous stroma. The round to oval cells showed cytoplasmic staining with vimentin and clusterin; CD34 labelled mostly cell membranes. The cells lacked SMA and S-100 expression. The central areas of the nodules were devoid of elastic fibers, but the periphery contained coarse fibers and globules. 9/ 11 patients, for whom clinical data were available, reported trauma to the scapular region. Many investigated ED were associated with trauma, which supports a reactive/degenerative etiology of ED. The abnormal large elastic fibers in all ED were enveloped by clusterin. Clusterin deposition may protect elastic fibers from degradation and thus contribute indirectly to the tumor-like presentation of ED.

  20. Introductory speeches

    International Nuclear Information System (INIS)

    2001-01-01

    This CD is multimedia presentation of programme safety upgrading of Bohunice V1 NPP. This chapter consist of introductory commentary and 4 introductory speeches (video records): (1) Introductory speech of Vincent Pillar, Board chairman and director general of Slovak electric, Plc. (SE); (2) Introductory speech of Stefan Schmidt, director of SE - Bohunice Nuclear power plants; (3) Introductory speech of Jan Korec, Board chairman and director general of VUJE Trnava, Inc. - Engineering, Design and Research Organisation, Trnava; Introductory speech of Dietrich Kuschel, Senior vice-president of FRAMATOME ANP Project and Engineering

  1. Cluster processes in gases and plasmas

    CERN Document Server

    Smirnov, Boris M

    2009-01-01

    Boris M. Smirnov received his Ph.D. in physics from Leningrad State University in 1968. After working in different research positions, he finally accepted a post as head of one of the divisions of the Institute for High Temperatures at the Russian Academy of Sciences in Moscow in 1986. Professor Smirnov is the author and co-author of approximately 50 books as well as 400 research articles in plasma physics, atomic physics, and atomic clusters. He is Vice Chairman of the National Council for Low Temperature Plasma and Chairman ofa Section on Elementary Processes in Plasma. Professor Smirnov`s r

  2. Gene expression inference with deep learning.

    Science.gov (United States)

    Chen, Yifei; Li, Yi; Narayan, Rajiv; Subramanian, Aravind; Xie, Xiaohui

    2016-06-15

    Large-scale gene expression profiling has been widely used to characterize cellular states in response to various disease conditions, genetic perturbations, etc. Although the cost of whole-genome expression profiles has been dropping steadily, generating a compendium of expression profiling over thousands of samples is still very expensive. Recognizing that gene expressions are often highly correlated, researchers from the NIH LINCS program have developed a cost-effective strategy of profiling only ∼1000 carefully selected landmark genes and relying on computational methods to infer the expression of remaining target genes. However, the computational approach adopted by the LINCS program is currently based on linear regression (LR), limiting its accuracy since it does not capture complex nonlinear relationship between expressions of genes. We present a deep learning method (abbreviated as D-GEX) to infer the expression of target genes from the expression of landmark genes. We used the microarray-based Gene Expression Omnibus dataset, consisting of 111K expression profiles, to train our model and compare its performance to those from other methods. In terms of mean absolute error averaged across all genes, deep learning significantly outperforms LR with 15.33% relative improvement. A gene-wise comparative analysis shows that deep learning achieves lower error than LR in 99.97% of the target genes. We also tested the performance of our learned model on an independent RNA-Seq-based GTEx dataset, which consists of 2921 expression profiles. Deep learning still outperforms LR with 6.57% relative improvement, and achieves lower error in 81.31% of the target genes. D-GEX is available at https://github.com/uci-cbcl/D-GEX CONTACT: xhx@ics.uci.edu Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  3. Expression of CD133 in acute leukemia.

    Science.gov (United States)

    Tolba, Fetnat M; Foda, Mona E; Kamal, Howyda M; Elshabrawy, Deena A

    2013-06-01

    There have been conflicting results regarding a correlation between CD133 expression and disease outcome. To assess CD133 expression in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and to evaluate its correlation with the different clinical and laboratory data as well as its relation to disease outcome, the present study included 60 newly diagnosed acute leukemic patients; 30 ALL patients with a male to female ratio of 1.5:1 and their ages ranged from 9 months to 48 years, and 30 AML patients with a male to female ratio of 1:1 and their ages ranged from 17 to 66 years. Flow cytometric assessment of CD133 expression was performed on blast cells. In ALL, no correlations were elicited between CD133 expression and some monoclonal antibodies, but in AML group, there was a significant positive correlation between CD133 and HLA-DR, CD3, CD7 and TDT, CD13 and CD34. In ALL group, patients with negative CD133 expression achieved complete remission more than patients with positive CD133 expression. In AML group, there was no statistically significant association found between positive CD133 expression and treatment outcome. The Kaplan-Meier curve illustrated a high significant negative correlation between CD133 expression and the overall survival of the AML patients. CD133 expression is an independent prognostic factor in acute leukemia, especially ALL patients and its expression could characterize a group of acute leukemic patients with higher resistance to standard chemotherapy and relapse. CD133 expression was highly associated with poor prognosis in acute leukemic patients.

  4. Foxp3 expression in human cancer cells

    Directory of Open Access Journals (Sweden)

    Gourgoulianis Konstantinos I

    2008-04-01

    Full Text Available Abstract Objective Transcription factor forkhead box protein 3 (Foxp3 specifically characterizes the thymically derived naturally occurring regulatory T cells (Tregs. Limited evidence indicates that it is also expressed, albeit to a lesser extent, in tissues other than thymus and spleen, while, very recently, it was shown that Foxp3 is expressed by pancreatic carcinoma. This study was scheduled to investigate whether expression of Foxp3 transcripts and mature protein occurs constitutively in various tumor types. Materials and methods Twenty five tumor cell lines of different tissue origins (lung cancer, colon cancer, breast cancer, melanoma, erythroid leukemia, acute T-cell leukemia were studied. Detection of Foxp3 mRNA was performed using both conventional RT-PCR and quantitative real-time PCR while protein expression was assessed by immunocytochemistry and flow cytometry, using different antibody clones. Results Foxp3 mRNA as well as Foxp3 protein was detected in all tumor cell lines, albeit in variable levels, not related to the tissue of origin. This expression correlated with the expression levels of IL-10 and TGFb1. Conclusion We offer evidence that Foxp3 expression, characterizes tumor cells of various tissue origins. The biological significance of these findings warrants further investigation in the context of tumor immune escape, and especially under the light of current anti-cancer efforts interfering with Foxp3 expression.

  5. Explanations for Contempt Expressed Towards Old People.

    Science.gov (United States)

    Maxwell, Eleanor Krassen; Maxwell, Robert J.

    The issue of contempt expressed towards the aged was examined from a cross-cultural perspective. Eight reasons for expressions of contempt emerged from a study of 95 societies drawn from the Standard Cross-Cultural Sample, and were treated as independent variables, with the overall level of contempt as the dependent variable, in a application of…

  6. Equilibrium-constant expressions for aqueous plutonium

    International Nuclear Information System (INIS)

    Silver, G.L.

    2010-01-01

    Equilibrium-constant expressions for Pu disproportionation reactions traditionally contain three or four terms representing the concentrations or fractions of the oxidation states. The expressions can be rewritten so that one of the oxidation states is replaced by a term containing the oxidation number of the plutonium. Experimental estimations of the numerical values of the constants can then be checked in several ways. (author)

  7. Behavior, Experience and Expression: Some Research Considerations.

    Science.gov (United States)

    Romanyshyn, Robert D.

    Utilizing research conducted on nostalgia, this paper shows how a phenomenological approach assists in understanding behavior, experience and expression. Moreover, a clearer understanding of them aids one's research with and comprehension of nostalgia. Human action can be studied from the experiential, behavioral and expressive perspectives. These…

  8. Serial analysis of gene expression (SAGE)

    NARCIS (Netherlands)

    van Ruissen, Fred; Baas, Frank

    2007-01-01

    In 1995, serial analysis of gene expression (SAGE) was developed as a versatile tool for gene expression studies. SAGE technology does not require pre-existing knowledge of the genome that is being examined and therefore SAGE can be applied to many different model systems. In this chapter, the SAGE

  9. Dihydrotestostenone increase the gene expression of androgen ...

    African Journals Online (AJOL)

    HNTEP cells were grown in basal medium and treated with DHT in different conditions. HNTEP cells under treatment with DHT (10-13 M) induced an increase in FHL-2 expression. In turn, high DHT concentrations (10-8 M) induced an increase in the expression SHP-1. The present data suggest that the SHP-1 and FHL-2 ...

  10. Predictable tuning of protein expression in bacteria

    DEFF Research Database (Denmark)

    Bonde, Mads; Pedersen, Margit; Klausen, Michael Schantz

    2016-01-01

    We comprehensively assessed the contribution of the Shine-Dalgarno sequence to protein expression and used the data to develop EMOPEC (Empirical Model and Oligos for Protein Expression Changes; http://emopec.biosustain.dtu.dk). EMOPEC is a free tool that makes it possible to modulate the expressi...

  11. A Robot with Complex Facial Expressions

    Directory of Open Access Journals (Sweden)

    J. Takeno

    2009-08-01

    Full Text Available The authors believe that the consciousness of humans basically originates from languages and their association-like flow of consciousness, and that feelings are generated accompanying respective languages. We incorporated artificial consciousness into a robot; achieved an association flow of language like flow of consciousness; and developed a robot called Kansei that expresses its feelings according to the associations occurring in the robot. To be able to fully communicate with humans, robots must be able to display complex expressions, such as a sense of being thrilled. We therefore added to the Kansei robot a device to express complex feelings through its facial expressions. The Kansei robot is actually an artificial skull made of aluminum, with servomotors built into it. The face is made of relatively soft polyethylene, which is formed to appear like a human face. Facial expressions are generated using 19 servomotors built into the skull, which pull metal wires attached to the facial “skin” to create expressions. The robot at present is capable of making six basic expressions as well as complex expressions, such as happiness and fear combined.

  12. Automating InDesign with Regular Expressions

    CERN Document Server

    Kahrel, Peter

    2006-01-01

    If you need to make automated changes to InDesign documents beyond what basic search and replace can handle, you need regular expressions, and a bit of scripting to make them work. This Short Cut explains both how to write regular expressions, so you can find and replace the right things, and how to use them in InDesign specifically.

  13. Construction of expression vectors carrying mouse peroxisomal ...

    African Journals Online (AJOL)

    The aim of this study was to construct expression vectors carrying mouse peroxisomal protein gene (PEP-cDNA) in prokaryotic and mammalian expression vectors in ... pGEX6p2-PEP and pUcD3-FLAG-PEP constructed vectors were transformed into the one shot TOP10 and JM105 bacterial competent cells, respectively.

  14. Assessment of Outcomes of Free Expression Courses.

    Science.gov (United States)

    Andsager, Julie; Ross, Susan Dente

    1999-01-01

    Assesses outcomes of instruction in three college-senior-level courses on freedom of expression. Suggests that increased attention to freedom-of-expression issues may have resulted in broader understanding of First Amendment issues, and individual and media rights. Notes that students seem to develop an appreciation of the reflexive nature of…

  15. Local expressions for one-loop calculations

    International Nuclear Information System (INIS)

    Wasson, D.A.; Koonin, S.E.

    1991-01-01

    We develop local expressions for the contributions of the short-wavelength vacuum modes to the one-loop vacuum energy. These expressions significantly improve the convergence properties of various ''brute-force'' calculational methods. They also provide a continuous series of approximations that interpolate between the brute-force calculations and the derivative expansion

  16. Artistic Expression: Another Challenge for Rural Education

    Directory of Open Access Journals (Sweden)

    Sonia Álvarez-Castro

    2012-12-01

    Full Text Available This paper identifies the parameters required to create opportunities that would strengthen the social fabric and would promote a comprehensive development through the artistic expression as a method for expressing feelings and constructing –cultural and social– identities as individuals, which, in our global context have been eroded by the homogenization of experiences.

  17. Dirichlet expression for L(1, χ )

    Indian Academy of Sciences (India)

    We show that this expression with obvious modification is valid for the general primitive Dirichlet character χ. Keywords. Hurwitz zeta function; Dirichlet character; Dirichlet L-series; primitive character. 1. Introduction. In Dirichlet's famous work dealing with class number formula, the value of L(1,χ) is expressed in terms of finite ...

  18. Sad Facial Expressions Increase Choice Blindness

    Directory of Open Access Journals (Sweden)

    Yajie Wang

    2018-01-01

    Full Text Available Previous studies have discovered a fascinating phenomenon known as choice blindness—individuals fail to detect mismatches between the face they choose and the face replaced by the experimenter. Although previous studies have reported a couple of factors that can modulate the magnitude of choice blindness, the potential effect of facial expression on choice blindness has not yet been explored. Using faces with sad and neutral expressions (Experiment 1 and faces with happy and neutral expressions (Experiment 2 in the classic choice blindness paradigm, the present study investigated the effects of facial expressions on choice blindness. The results showed that the detection rate was significantly lower on sad faces than neutral faces, whereas no significant difference was observed between happy faces and neutral faces. The exploratory analysis of verbal reports found that participants who reported less facial features for sad (as compared to neutral expressions also tended to show a lower detection rate of sad (as compared to neutral faces. These findings indicated that sad facial expressions increased choice blindness, which might have resulted from inhibition of further processing of the detailed facial features by the less attractive sad expressions (as compared to neutral expressions.

  19. Sad Facial Expressions Increase Choice Blindness.

    Science.gov (United States)

    Wang, Yajie; Zhao, Song; Zhang, Zhijie; Feng, Wenfeng

    2017-01-01

    Previous studies have discovered a fascinating phenomenon known as choice blindness-individuals fail to detect mismatches between the face they choose and the face replaced by the experimenter. Although previous studies have reported a couple of factors that can modulate the magnitude of choice blindness, the potential effect of facial expression on choice blindness has not yet been explored. Using faces with sad and neutral expressions (Experiment 1) and faces with happy and neutral expressions (Experiment 2) in the classic choice blindness paradigm, the present study investigated the effects of facial expressions on choice blindness. The results showed that the detection rate was significantly lower on sad faces than neutral faces, whereas no significant difference was observed between happy faces and neutral faces. The exploratory analysis of verbal reports found that participants who reported less facial features for sad (as compared to neutral) expressions also tended to show a lower detection rate of sad (as compared to neutral) faces. These findings indicated that sad facial expressions increased choice blindness, which might have resulted from inhibition of further processing of the detailed facial features by the less attractive sad expressions (as compared to neutral expressions).

  20. Biased Facial Expression Interpretation in Shy Children

    Science.gov (United States)

    Kokin, Jessica; Younger, Alastair; Gosselin, Pierre; Vaillancourt, Tracy

    2016-01-01

    The relationship between shyness and the interpretations of the facial expressions of others was examined in a sample of 123 children aged 12 to 14?years. Participants viewed faces displaying happiness, fear, anger, disgust, sadness, surprise, as well as a neutral expression, presented on a computer screen. The children identified each expression…

  1. Characterization of differentially expressed genes using high-dimensional co-expression networks

    DEFF Research Database (Denmark)

    Coelho Goncalves de Abreu, Gabriel; Labouriau, Rodrigo S.

    2010-01-01

    We present a technique to characterize differentially expressed genes in terms of their position in a high-dimensional co-expression network. The set-up of Gaussian graphical models is used to construct representations of the co-expression network in such a way that redundancy and the propagation...... that allow to make effective inference in problems with high degree of complexity (e.g. several thousands of genes) and small number of observations (e.g. 10-100) as typically occurs in high throughput gene expression studies. Taking advantage of the internal structure of decomposable graphical models, we...... construct a compact representation of the co-expression network that allows to identify the regions with high concentration of differentially expressed genes. It is argued that differentially expressed genes located in highly interconnected regions of the co-expression network are less informative than...

  2. Polycistronic gene expression in Aspergillus niger.

    Science.gov (United States)

    Schuetze, Tabea; Meyer, Vera

    2017-09-25

    Genome mining approaches predict dozens of biosynthetic gene clusters in each of the filamentous fungal genomes sequenced so far. However, the majority of these gene clusters still remain cryptic because they are not expressed in their natural host. Simultaneous expression of all genes belonging to a biosynthetic pathway in a heterologous host is one approach to activate biosynthetic gene clusters and to screen the metabolites produced for bioactivities. Polycistronic expression of all pathway genes under control of a single and tunable promoter would be the method of choice, as this does not only simplify cloning procedures, but also offers control on timing and strength of expression. However, polycistronic gene expression is a feature not commonly found in eukaryotic host systems, such as Aspergillus niger. In this study, we tested the suitability of the viral P2A peptide for co-expression of three genes in A. niger. Two genes descend from Fusarium oxysporum and are essential to produce the secondary metabolite enniatin (esyn1, ekivR). The third gene (luc) encodes the reporter luciferase which was included to study position effects. Expression of the polycistronic gene cassette was put under control of the Tet-On system to ensure tunable gene expression in A. niger. In total, three polycistronic expression cassettes which differed in the position of luc were constructed and targeted to the pyrG locus in A. niger. This allowed direct comparison of the luciferase activity based on the position of the luciferase gene. Doxycycline-mediated induction of the Tet-On expression cassettes resulted in the production of one long polycistronic mRNA as proven by Northern analyses, and ensured comparable production of enniatin in all three strains. Notably, gene position within the polycistronic expression cassette matters, as, luciferase activity was lowest at position one and had a comparable activity at positions two and three. The P2A peptide can be used to express at

  3. Expression of Sox genes in tooth development.

    Science.gov (United States)

    Kawasaki, Katsushige; Kawasaki, Maiko; Watanabe, Momoko; Idrus, Erik; Nagai, Takahiro; Oommen, Shelly; Maeda, Takeyasu; Hagiwara, Nobuko; Que, Jianwen; Sharpe, Paul T; Ohazama, Atsushi

    2015-01-01

    Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.

  4. Emotion Expression of Robot with Personality

    Directory of Open Access Journals (Sweden)

    Xue Hu

    2013-01-01

    Full Text Available A robot emotional expression model based on Hidden Markov Model (HMM is built to enable robots which have different personalities to response in a more satisfactory emotional level. Gross emotion regulation theory and Five Factors Model (FFM which are the theoretical basis are firstly described. And then the importance of the personality effect on the emotion expression process is proposed, and how to make the effect quantization is discussed. After that, the algorithm of HMM is used to describe the process of emotional state transition and expression, and the performance transferring probability affected by personality is calculated. At last, the algorithm model is simulated and applied in a robot platform. The results prove that the emotional expression model can acquire humanlike expressions and improve the human-computer interaction.

  5. Willingness to express emotions to caregiving spouses.

    Science.gov (United States)

    Monin, Joan K; Martire, Lynn M; Schulz, Richard; Clark, Margaret S

    2009-02-01

    This study examined the association between care-recipients' willingness to express emotions to spousal caregivers and caregiver's well-being and support behaviors. Using self-report measures in the context of a larger study, 262 care-recipients with osteoarthritis reported on their willingness to express emotions to caregivers, and caregivers reported on their stress and insensitive responding to care-recipients. Results revealed that care-recipients' willingness to express happiness was associated with less insensitive caregiver responding, and willingness to express interpersonal emotions (e.g., compassion, guilt) was associated with less caregiving stress. There were also gender differences, such that caregiving wives, in particular, benefited from their husband's willingness to express vulnerable (e.g., anxiety, sadness) and interpersonal emotions. (c) 2009 APA, all rights reserved

  6. Personality expression in Chinese language use.

    Science.gov (United States)

    Qiu, Lin; Lu, Jiahui; Ramsay, Jonathan; Yang, Shanshan; Qu, Weina; Zhu, Tingshao

    2017-12-01

    To date, little research has investigated personality expressions in languages other than English. Given that the Chinese language has the largest number of native speakers in the world, it is vitally important to examine the associations between personality and Chinese language use. In this research, we analysed Chinese microblogs and identified word categories and factorial structures associated with personality traits. We also compared our results with previous findings in English and showed that linguistic expression of personality has both universal- and language-specific aspects. Expression of personality via content words is more likely to be consistent across languages than expression via function words. This makes an important step towards uncovering universal patterns of personality expression in language. © 2016 International Union of Psychological Science.

  7. PRAME gene expression profile in medulloblastoma

    Directory of Open Access Journals (Sweden)

    Tânia Maria Vulcani-Freitas

    2011-02-01

    Full Text Available Medulloblastoma is the most common malignant tumors of central nervous system in the childhood. The treatment is severe, harmful and, thus, has a dismal prognosis. As PRAME is present in various cancers, including meduloblastoma, and has limited expression in normal tissues, this antigen can be an ideal vaccine target for tumor immunotherapy. In order to find a potential molecular target, we investigated PRAME expression in medulloblastoma fragments and we compare the results with the clinical features of each patient. Analysis of gene expression was performed by real-time quantitative PCR from 37 tumor samples. The Mann-Whitney test was used to analysis the relationship between gene expression and clinical characteristics. Kaplan-Meier curves were used to evaluate survival. PRAME was overexpressed in 84% samples. But no statistical association was found between clinical features and PRAME overexpression. Despite that PRAME gene could be a strong candidate for immunotherapy since it is highly expressed in medulloblastomas.

  8. Determining Physical Mechanisms of Gene Expression Regulation from Single Cell Gene Expression Data

    OpenAIRE

    Ezer, Daphne; Moignard, Victoria; G?ttgens, Berthold; Adryan, Boris

    2016-01-01

    Many genes are expressed in bursts, which can contribute to cell-to-cell heterogeneity. It is now possible to measure this heterogeneity with high throughput single cell gene expression assays (single cell qPCR and RNA-seq). These experimental approaches generate gene expression distributions which can be used to estimate the kinetic parameters of gene expression bursting, namely the rate that genes turn on, the rate that genes turn off, and the rate of transcription. We construct a complete ...

  9. The MPI facial expression database--a validated database of emotional and conversational facial expressions.

    Directory of Open Access Journals (Sweden)

    Kathrin Kaulard

    Full Text Available The ability to communicate is one of the core aspects of human life. For this, we use not only verbal but also nonverbal signals of remarkable complexity. Among the latter, facial expressions belong to the most important information channels. Despite the large variety of facial expressions we use in daily life, research on facial expressions has so far mostly focused on the emotional aspect. Consequently, most databases of facial expressions available to the research community also include only emotional expressions, neglecting the largely unexplored aspect of conversational expressions. To fill this gap, we present the MPI facial expression database, which contains a large variety of natural emotional and conversational expressions. The database contains 55 different facial expressions performed by 19 German participants. Expressions were elicited with the help of a method-acting protocol, which guarantees both well-defined and natural facial expressions. The method-acting protocol was based on every-day scenarios, which are used to define the necessary context information for each expression. All facial expressions are available in three repetitions, in two intensities, as well as from three different camera angles. A detailed frame annotation is provided, from which a dynamic and a static version of the database have been created. In addition to describing the database in detail, we also present the results of an experiment with two conditions that serve to validate the context scenarios as well as the naturalness and recognizability of the video sequences. Our results provide clear evidence that conversational expressions can be recognized surprisingly well from visual information alone. The MPI facial expression database will enable researchers from different research fields (including the perceptual and cognitive sciences, but also affective computing, as well as computer vision to investigate the processing of a wider range of natural

  10. The MPI Facial Expression Database — A Validated Database of Emotional and Conversational Facial Expressions

    Science.gov (United States)

    Kaulard, Kathrin; Cunningham, Douglas W.; Bülthoff, Heinrich H.; Wallraven, Christian

    2012-01-01

    The ability to communicate is one of the core aspects of human life. For this, we use not only verbal but also nonverbal signals of remarkable complexity. Among the latter, facial expressions belong to the most important information channels. Despite the large variety of facial expressions we use in daily life, research on facial expressions has so far mostly focused on the emotional aspect. Consequently, most databases of facial expressions available to the research community also include only emotional expressions, neglecting the largely unexplored aspect of conversational expressions. To fill this gap, we present the MPI facial expression database, which contains a large variety of natural emotional and conversational expressions. The database contains 55 different facial expressions performed by 19 German participants. Expressions were elicited with the help of a method-acting protocol, which guarantees both well-defined and natural facial expressions. The method-acting protocol was based on every-day scenarios, which are used to define the necessary context information for each expression. All facial expressions are available in three repetitions, in two intensities, as well as from three different camera angles. A detailed frame annotation is provided, from which a dynamic and a static version of the database have been created. In addition to describing the database in detail, we also present the results of an experiment with two conditions that serve to validate the context scenarios as well as the naturalness and recognizability of the video sequences. Our results provide clear evidence that conversational expressions can be recognized surprisingly well from visual information alone. The MPI facial expression database will enable researchers from different research fields (including the perceptual and cognitive sciences, but also affective computing, as well as computer vision) to investigate the processing of a wider range of natural facial expressions

  11. Vitamin D Receptor Expression in Dogs

    Science.gov (United States)

    Gow, A.G.; Milne, E.; Drummond, D.; Smith, S.; Handel, I.; Mellanby, R.J.

    2018-01-01

    Background There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and in dogs. Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Little is known about which non‐skeletal tissues express the VDR or how inflammation influences its expression in the dog. Objectives To define which non‐skeletal canine tissues express the VDR and to investigate expression in inflamed small intestine. Animals Thirteen non‐skeletal tissues were collected prospectively from 6 control dogs. Thirty‐five dogs diagnosed with a chronic enteropathy (CE) and 24 control dogs were prospectively enrolled and duodenal biopsies were evaluated for VDR expression. Methods Prospective; blinded assessment of canine intestinal VDR. Dogs with CE were included once other identifiable causes of intestinal disease were excluded. Age matched controls were included with no intestinal clinical signs. VDR expression was assessed immunohistochemically in all samples, using a Rat IgG VDR monoclonal antibody. Quantitative real‐time polymerase chain reaction (qPCR) was also used for duodenal biopsies. Results VDR expression as assessed by immunohistochemistry (IHC) was highest in the kidney, duodenum, skin, ileum and spleen, and weak in the colon, heart, lymph node, liver, lung, and ovary. Gastric and testicular tissue did not express the VDR. There was no statistical difference in duodenal VDR expression between the 24 healthy dogs and 34 dogs with CE when quantified by either qPCR (P = 0.87) or IHC (P = 0.099). Conclusions and Clinical Importance The lack of down regulation of VDR expression in inflamed intestine contrasts with previous studies in humans. Our findings support future studies to investigate whether vitamin D and its analogues can be used to modulate intestinal inflammation in the dog. PMID:29469965

  12. The functional landscape of mouse gene expression

    Directory of Open Access Journals (Sweden)

    Zhang Wen

    2004-12-01

    Full Text Available Abstract Background Large-scale quantitative analysis of transcriptional co-expression has been used to dissect regulatory networks and to predict the functions of new genes discovered by genome sequencing in model organisms such as yeast. Although the idea that tissue-specific expression is indicative of gene function in mammals is widely accepted, it has not been objectively tested nor compared with the related but distinct strategy of correlating gene co-expression as a means to predict gene function. Results We generated microarray expression data for nearly 40,000 known and predicted mRNAs in 55 mouse tissues, using custom-built oligonucleotide arrays. We show that quantitative transcriptional co-expression is a powerful predictor of gene function. Hundreds of functional categories, as defined by Gene Ontology 'Biological Processes', are associated with characteristic expression patterns across all tissues, including categories that bear no overt relationship to the tissue of origin. In contrast, simple tissue-specific restriction of expression is a poor predictor of which genes are in which functional categories. As an example, the highly conserved mouse gene PWP1 is widely expressed across different tissues but is co-expressed with many RNA-processing genes; we show that the uncharacterized yeast homolog of PWP1 is required for rRNA biogenesis. Conclusions We conclude that 'functional genomics' strategies based on quantitative transcriptional co-expression will be as fruitful in mammals as they have been in simpler organisms, and that transcriptional control of mammalian physiology is more modular than is generally appreciated. Our data and analyses provide a public resource for mammalian functional genomics.

  13. Simultaneous Breast Expression in Breastfeeding Women Is More Efficacious Than Sequential Breast Expression

    Science.gov (United States)

    Garbin, Catherine P.; Hartmann, Peter E.; Kent, Jacqueline C.

    2012-01-01

    Abstract Introduction Simultaneous (SIM) breast expression saves mothers time compared with sequential (SEQ) expression, but it remains unclear whether the two methods differ in milk output efficiency and efficacy. Subjects and Methods The Showmilk device (Medela AG, Baar, Switzerland) was used to measure milk output and milk ejection during breast expression (electric pump) in 31 Australian breastfeeding mothers of term infants (median age, 19 weeks [interquartile range, 10–33 weeks]). The order of expression type (SIM/SEQ) and breast (left/right) was randomized. Results SIM expression yielded more milk ejections (p≤0.001) and greater amounts of milk at 2, 5, and 10 minutes (p≤0.01) and removed a greater total amount of milk (p≤0.01) and percentage of available milk (p<0.05) than SEQ expression. After SIM expression the cream content of both the overall (8.3% [p≤0.05]) and postexpression (12.6% [p≤0.001]) milk were greater. During SEQ expression, the breast expressed first had a shorter time to 50% and 80% of the total amount of milk than the breast expressed second (p≤0.05), but, overall, a similar percentage of available milk was removed from both breasts. Conclusions SIM expression stimulated more milk ejections and was a more efficient and efficacious method of expression, yielding milk with a higher energy content. PMID:23039397

  14. The Relations of Mothers' Negative Expressivity to Children's Experience and Expression of Negative Emotion

    Science.gov (United States)

    Valiente, Carlos; Eisenberg, Nancy; Shepard, Stephanie A.; Fabes, Richard A.; Cumberland, Amanda J.; Losoya, Sandra H.; Spinrad, Tracy L.

    2004-01-01

    Guided by the heuristic model proposed by Eisenberg et al. [Psychol. Inq. 9 (1998) 241], we examined the relations of mothers' reported and observed negative expressivity to children's (N = 159; 74 girls; M age = 7.67 years) experience and expression of emotion. Children's experience and/or expression of emotion in response to a distressing film…

  15. Recognition, Expression, and Understanding Facial Expressions of Emotion in Adolescents with Nonverbal and General Learning Disabilities

    Science.gov (United States)

    Bloom, Elana; Heath, Nancy

    2010-01-01

    Children with nonverbal learning disabilities (NVLD) have been found to be worse at recognizing facial expressions than children with verbal learning disabilities (LD) and without LD. However, little research has been done with adolescents. In addition, expressing and understanding facial expressions is yet to be studied among adolescents with LD…

  16. ["Les Impatients": expression through art].

    Science.gov (United States)

    Lamontagne, Céline; Palardy, Lorraine

    2015-01-01

    The organization called "Les Impatients" was founded in 1992. Using a unique model, Les Impatients welcomes those with mental health issues who would like to express themselves through art. Les Impatients offers free creative workshops and encourages exchanges with the community through the sharing of its participants' creations. The name Les Impatients reinforces the idea that the organization does not consider those attending its workshops as patients, but rather creators who are eager to heal, develop their craft and find their place in society. The participants contribute to the collective objective of breaking down the stigma that surrounds mental illness.Les Impatients collaborates with various mental health organizations in Quebec, such as the Institut universitaire en santé mentale de Montréal (IUSMM) affiliated to the Université de Montréal, Douglas Mental Health University Institute (DMHUI), the Centre de santé et services sociaux Drummond (CSSS Drummond) and the Centre de santé et services sociaux Pierre-Boucher (CSSS Pierre-Boucher). Les Impatients offers more than 48 workshops in eight different locations to around 450 participants each week.Dissemination activities, remarkable events, original projects: Les Impatients stands out through its realizations. Examples are exhibitions, collections of love letters, comic books, CD, concerts, and reading nights. The organization's originality resides in the exploration of the links between the work of the participants and that of professional artists. An illustration of this interest is the annual Parle-moi d'amour auction-exhibition, which has been one of Les Impatients' major events since 1999.As part of its mission, Les Impatients conserves the works of art created by the participants during the workshops. Its collection includes more than 15,000 works of art from Les Impatients as well as pieces donated by collectors of unconventional art, commonly known as "art brut" or "outsider art". The

  17. 78 FR 42064 - Before Commissioners: Jon Wellinghoff, Chairman; Philip D. Moeller, John R. Norris, Cheryl A...

    Science.gov (United States)

    2013-07-15

    ... Transmission Organizations (Joint ISOs/RTOs) filed a joint motion to intervene out-of-time and comments on NERC's Petition.\\13\\ In support of their request for leave to intervene out-of-time, Joint ISOs/RTOs... the January 30, 2013 close of the intervention and comment period. Joint ISOs/RTOs maintain that their...

  18. Prof. Manfred Popp, Chairman of the Executive Board, Forschungszentrum Karlsruhe GmbH

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Prof. Popp is pictured here in the ATLAS detector assembly hall with Dr. Horst Wenninger of CERN.Photo 01: Prof. Popp (right) and Dr. Wenninger in front of one of the two vacuum vessels for the ATLAS end-cap toroid magnets.Photo 02: Prof. Popp (right) and Dr. Wenninger in front of one of eight 25-metre-long aluminium-alloy coil casings that will house the racetrack coils of the barrel toroid magnet system.

  19. ACHP | News | ACHP Chairman Nau Speaks on "The Economic Potential of

    Science.gov (United States)

    billion in direct heritage tourism expenditures, an additional $1.7 billion in generated indirect impacts related business and development opportunities in an industry that is called heritage tourism. A question : Why did the Texas House of Representatives recently identify the heritage tourism program of the Texas

  20. Tips for the PR Chairman for Education Associations. PR Bookshelf No. 2.

    Science.gov (United States)

    National Education Association, Washington, DC.

    This booklet is intended to aid leaders of local education associations in developing a continuing public relations (PR) program aimed at establishing and maintaining a favorable public image for teachers. Although it offers useful guidelines for developing a PR program, the booklet does not contain lists of specific things to do. Instead, it…

  1. Second Symposium on ''Current trends in international fusion research: review and assessment''. Chairman's summary of session

    International Nuclear Information System (INIS)

    Post, R.F.

    1998-01-01

    This session began with a keynote speech by B. Coppi of M.I.T., entitled: ''Physics of Fusion Burning Plasmas, Ignition, and Relevant Technology Issues.'' It continued with a second paper on the tokamak approach to fusion, presented by E. Mazzucato of the Princeton Plasma Physics Laboratory, entitled ''High Confinement Plasma Confinement Regime in TFTR Configurations with Reversed Magnetic Shear.'' The session continued with three talks discussing various aspects of the so-called ''Field Reversed Configuration'' (FRC), and concluded with a talk on a more general topic. The first of the three FRC papers, presented by J. Slough of the University of Washington, was entitled ''FRC Reactor for Deep Space Propulsion.'' This paper was followed by a paper by S. Goto of the Plasma Physics Laboratory of Osaka University in Japan, entitled ''Experimental Initiation of Field-Reversed Configuration (FRC) Toward Helium-3 Fusion.'' The third of the FRC papers, authored by H. Mimoto and Y. Tomito of the National Institute for Fusion Science, Nagoya, Japan, and presented by Y. Tomita was entitled ''Helium-3 Fusion Based on a Field-Reversed Configuration.'' The session was concluded with a paper presented by D. Ryutov of the Lawrence Livermore National Laboratory entitled: ''A User Facility for Research on Fusion Systems with Dense Plasmas.''

  2. Chairman's report for period 1 April 1979 to 31 March 1981

    International Nuclear Information System (INIS)

    De Villiers, J.W.R.

    1981-01-01

    The report gives an account of the activities of the Southern Universities Nuclear Institute for the period 1979-1981. A short discussion of basic and applied research programmes undertaken during this period is given. Nuclear level parameters using charged particle induced reactions were studied. Mono-energetic neutron sources obtained from the SUNI accelerator were calibrated. Prompt nuclear methods have been extensively studied. The main part of the solid state and materials research programme constituted thin film semiconductor studies with much attention being given to metal silicides. With regard to atomic physics, research on the energy level structure of highly ionized rare gases was continued and the spectrum of krypton analyzed. Projects of biomedical interest were also undertaken, mainly with regard to trace elements. Nuclear techniques were also applied to industrial and environmental problems

  3. IFSSH Flexor Tendon Committee report 2014: from the IFSSH Flexor Tendon Committee (Chairman: Jin Bo Tang).

    Science.gov (United States)

    Tang, Jin Bo; Chang, James; Elliot, David; Lalonde, Donald H; Sandow, Michael; Vögelin, Esther

    2014-01-01

    Hand surgeons continue to search for the best surgical flexor tendon repair and treatment of the tendon sheaths and pulleys, and they are attempting to establish postoperative regimens that fit diverse clinical needs. It is the purpose of this report to present the current views, methods, and suggestions of six senior hand surgeons from six different countries - all experienced in tendon repair and reconstruction. Although certainly there is common ground, the report presents provocative views and approaches. The report reflects an update in the views of the committee. We hope that it is helpful to surgeons and therapists in treating flexor tendon injuries.

  4. Impression management and self-presentation dissimulation in Portuguese chairman's statements

    OpenAIRE

    Oliveira, J.; Azevedo, G.; Borges, F.

    2016-01-01

    WOS:000381979800008 (Nº de Acesso Web of Science) Drawn on social psychology theory of impression management, the present study tries to assess the way Portuguese managers build their narratives in Chairman’s Statement to manage stakeholders’ perceptions on corporate image, in a period of time of scarce resources. The paper’s theoretical framework draws on elements of social psychology theory of impression management developed by Leary and Kowalski (1990). Through the use of the two-compon...

  5. [Remarks by the Honorable Ralph Regula, Chairman of the Subcommittee on Appropriations

    Energy Technology Data Exchange (ETDEWEB)

    Regula, R. [U.S. House of Representatives, Washington, DC (United States)

    1997-12-31

    The emphasis of this presentation is on education -- education on environmental issues, deregulation of the electric power industry, the Clean Air question, balancing the national budget, and economic growth for the US. These issues are briefly discussed in relation to possible congressional action.

  6. Chairman report on the IWG-NPPCI activities May 1984/March 1986

    International Nuclear Information System (INIS)

    Bastl, W.

    1986-01-01

    A summary of the IWG-NPPCI activities in the past two years is presented. Meetings and training courses were held, publications were prepared and coordinated research programs were launched and discussed

  7. Chairman of the Joint Chiefs of Staff Strategy Essay Competition: Essays 2002

    Science.gov (United States)

    2002-10-01

    onset of hostilities, one overarching concern is the very nature of the surrogate. Allies of convenience may not be great people or savory characters, and...government were invariably failures.”51 Williamson Murray and Allan Millett observed in their work on net as- sessments, “If it is difficult to calculate...Military Innovation in Peacetime,” in Williamson Murray and Allan R. Millett, eds., Military Innovation in the Interwar Period (New York: Cambridge

  8. Sorry Mr. Chairman, can we stop the meeting, we have a plane to catch

    DEFF Research Database (Denmark)

    Mandrup, Thomas

    The Post-apartheid South African armed forces (SANDF) was born as product of the political settlement. The statutory and non-statutory forces were integrated into one national force. However, the merged force have been characterised by schizophrenia in the sense that it has been a force caught be...

  9. Introductory remarks by the Chairman. [Session 1: Environmental and health consequences of the Chernobyl accident

    International Nuclear Information System (INIS)

    Bennett, B.G.

    2005-01-01

    Many scientists as well as representatives from UN organizations and governments of affected regions participated in the work of the Chernobyl Forum. Several meetings of the Forum were necessary to initiate the work and monitor the progress of the expert groups. Two expert groups formulated comprehensive reports - one on environmental issues, organized by the IAEA, and one on health issues, organized by the WHO. Experts from throughout the world were invited to contribute to these evaluations. The representatives of governments and the staff of international organizations then reviewed the results of these groups to be sure that the reviews were complete and the evaluations reasonable, so that they could serve as the basis for consensus agreements and effective recommendations for further dealing with the consequences of the accident

  10. Symposium on Highlights from 14 years of LEAR Physics : R. Landua (chairman)

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  11. Open Letter from the GAC-EPA to the Chairman of the PFGB

    CERN Document Server

    GAC-EPA

    2012-01-01

    Mr. President, As I had the opportunity to tell you last June, we are satisfied that, at your initiative, better communication has been put into place towards the members and beneficiaries of the Pension Fund who, I am sure, appreciate your decision to publish regularly articles in the CERN Bulletin. In your article in No. 30+31 dated 25 July 2012, you mention that the Fund continues the implementation of the capital preservation approach and you announce a return on investments by the Fund of 2.0% as of 31 May 2012. You compare this number to a change by -8.5% in the Eurostoxx50 index. The Fund’s return is certainly more favourable than the one obtained in 2011, but we should not forget that an evaluation of the Fund’s performance has to take into account two elements: its return objective fixed at 3% above inflation , and the result of a comparison with other providence schemes. A direct estimate of the quality of the management of our Fund is possible by making comparisons with ins...

  12. IPAA chairman sees E and P as creative side of business

    International Nuclear Information System (INIS)

    Tippee, B.

    1993-01-01

    For George A. Alcorn, exploration and production represent the creative side of the oil and gas business. The author is quick to point out the creative side's problems: unstable commodity prices, taxes, a shortage of capital, strict and changing environmental regulations, and limited access to federal land. The author gives his experienced view on price stability, U.S. opportunities, and prospects for the natural gas market

  13. Micro-Expression Recognition Using Color Spaces.

    Science.gov (United States)

    Wang, Su-Jing; Yan, Wen-Jing; Li, Xiaobai; Zhao, Guoying; Zhou, Chun-Guang; Fu, Xiaolan; Yang, Minghao; Tao, Jianhua

    2015-12-01

    Micro-expressions are brief involuntary facial expressions that reveal genuine emotions and, thus, help detect lies. Because of their many promising applications, they have attracted the attention of researchers from various fields. Recent research reveals that two perceptual color spaces (CIELab and CIELuv) provide useful information for expression recognition. This paper is an extended version of our International Conference on Pattern Recognition paper, in which we propose a novel color space model, tensor independent color space (TICS), to help recognize micro-expressions. In this paper, we further show that CIELab and CIELuv are also helpful in recognizing micro-expressions, and we indicate why these three color spaces achieve better performance. A micro-expression color video clip is treated as a fourth-order tensor, i.e., a four-dimension array. The first two dimensions are the spatial information, the third is the temporal information, and the fourth is the color information. We transform the fourth dimension from RGB into TICS, in which the color components are as independent as possible. The combination of dynamic texture and independent color components achieves a higher accuracy than does that of RGB. In addition, we define a set of regions of interests (ROIs) based on the facial action coding system and calculated the dynamic texture histograms for each ROI. Experiments are conducted on two micro-expression databases, CASME and CASME 2, and the results show that the performances for TICS, CIELab, and CIELuv are better than those for RGB or gray.

  14. Glucose transporters: expression, regulation and cancer

    Directory of Open Access Journals (Sweden)

    RODOLFO A. MEDINA

    2002-01-01

    Full Text Available Mammalian cells depend on glucose as a major substrate for energy production. Glucose is transported into the cell via facilitative glucose transporters (GLUT present in all cell types. Many GLUT isoforms have been described and their expression is cell-specific and subject to hormonal and environmental control. The kinetic properties and substrate specificities of the different isoforms are specifically suited to the energy requirements of the particular cell types. Due to the ubiquitousness of these transporters, their differential expression is involved in various disease states such as diabetes, ischemia and cancer. The majority of cancers and isolated cancer cell lines over-express the GLUT family members which are present in the respective tissue of origin under non-cancerous conditions. Moreover, due to the requirement of energy to feed uncontrolled proliferation, cancer cells often express GLUTs which under normal conditions would not be present in these tissues. This over-expression is predominantly associated with the likelihood of metastasis and hence poor patient prognosis. This article presents a review of the current literature on the regulation and expression of GLUT family members and has compiled clinical and research data on GLUT expression in human cancers and in isolated human cancer cell lines.

  15. Regular Expression Matching and Operational Semantics

    Directory of Open Access Journals (Sweden)

    Asiri Rathnayake

    2011-08-01

    Full Text Available Many programming languages and tools, ranging from grep to the Java String library, contain regular expression matchers. Rather than first translating a regular expression into a deterministic finite automaton, such implementations typically match the regular expression on the fly. Thus they can be seen as virtual machines interpreting the regular expression much as if it were a program with some non-deterministic constructs such as the Kleene star. We formalize this implementation technique for regular expression matching using operational semantics. Specifically, we derive a series of abstract machines, moving from the abstract definition of matching to increasingly realistic machines. First a continuation is added to the operational semantics to describe what remains to be matched after the current expression. Next, we represent the expression as a data structure using pointers, which enables redundant searches to be eliminated via testing for pointer equality. From there, we arrive both at Thompson's lockstep construction and a machine that performs some operations in parallel, suitable for implementation on a large number of cores, such as a GPU. We formalize the parallel machine using process algebra and report some preliminary experiments with an implementation on a graphics processor using CUDA.

  16. The Communicative Function of Sad Facial Expressions.

    Science.gov (United States)

    Reed, Lawrence Ian; DeScioli, Peter

    2017-01-01

    What are the communicative functions of sad facial expressions? Research shows that people feel sadness in response to losses but it's unclear whether sad expressions function to communicate losses to others and if so, what makes these signals credible. Here we use economic games to test the hypothesis that sad expressions lend credibility to claims of loss. Participants play the role of either a proposer or recipient in a game with a fictional backstory and real monetary payoffs. The proposers view a (fictional) video of the recipient's character displaying either a neutral or sad expression paired with a claim of loss. The proposer then decided how much money to give to the recipient. In three experiments, we test alternative theories by using situations in which the recipient's losses were uncertain (Experiment 1), the recipient's losses were certain (Experiment 2), or the recipient claims failed gains rather than losses (Experiment 3). Overall, we find that participants gave more money to recipients who displayed sad expressions compared to neutral expressions, but only under conditions of uncertain loss. This finding supports the hypothesis that sad expressions function to increase the credibility of claims of loss.

  17. Expressive Dissonance: When Emotional Inconsistency Arouses Dissonance

    Directory of Open Access Journals (Sweden)

    Audrey Pelt

    2018-05-01

    Full Text Available The aim of the two studies was to explore a new dissonance paradigm–expressive dissonance–based on the inconsistency between what people feel and what people express behaviorally. Expressive dissonance was aroused by asking participants to watch a film with a high emotional content, either positive (joy or negative (sadness. In the no-dissonance condition, they received the instruction to naturally watch the film. In the expressive dissonance condition, they received the instruction to facially express emotions that were the opposite of what they felt. We expected that the expressive dissonance situation would: 1 require cognitive resources leading to a decrease in cognitive performance (studies 1 and 2; 2 be accompanied by emotional regulation strategies (study 1; 3 be accompanied by an increase in dissonance-related affects (study 2. Although our results (studies 1 and 2 corroborated those obtained previously in terms of performance, they also showed that participants in the expressive dissonance situation use emotional regulation strategies: exaggeration and suppression (study 1, and that they felt self-directed negative affects (study 2, just like the participants in a cognitive dissonance situation. These first results allowed us to establish a theoretical bridge between the theories of emotions–particularly those related to the emotional regulation processes–and to widen the scope of relevance of the dissonance theory.

  18. Gene expression and gene therapy imaging

    International Nuclear Information System (INIS)

    Rome, Claire; Couillaud, Franck; Moonen, Chrit T.W.

    2007-01-01

    The fast growing field of molecular imaging has achieved major advances in imaging gene expression, an important element of gene therapy. Gene expression imaging is based on specific probes or contrast agents that allow either direct or indirect spatio-temporal evaluation of gene expression. Direct evaluation is possible with, for example, contrast agents that bind directly to a specific target (e.g., receptor). Indirect evaluation may be achieved by using specific substrate probes for a target enzyme. The use of marker genes, also called reporter genes, is an essential element of MI approaches for gene expression in gene therapy. The marker gene may not have a therapeutic role itself, but by coupling the marker gene to a therapeutic gene, expression of the marker gene reports on the expression of the therapeutic gene. Nuclear medicine and optical approaches are highly sensitive (detection of probes in the picomolar range), whereas MRI and ultrasound imaging are less sensitive and require amplification techniques and/or accumulation of contrast agents in enlarged contrast particles. Recently developed MI techniques are particularly relevant for gene therapy. Amongst these are the possibility to track gene therapy vectors such as stem cells, and the techniques that allow spatiotemporal control of gene expression by non-invasive heating (with MRI guided focused ultrasound) and the use of temperature sensitive promoters. (orig.)

  19. Expression of multidrug resistance proteins in retinoblastoma

    Directory of Open Access Journals (Sweden)

    Swati Shukla

    2017-11-01

    Full Text Available AIM: To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug resistance. METHODS: Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or carboplatin, which are used for conventional chemotherapy in RB. Primary cultures from enucleated eyes after chemotherapy (PCNC were also prepared. Their chemosensitivity to chemotherapeutic agents (vincristine, etoposide and carboplatin were measured using MTT assay. Western blot analysis was performed to evaluate the expression of p53, Bcl-2 and various multidrug resistant proteins in retinoblastoma cells. RESULTS: Following exposure to chemotherapeutic drugs, PCNC showed less sensitivity to drugs. No significant changes observed in the p53 expression, whereas Bcl-2 expression was found to be increased in the drug resistant cells as well as in PCNC. Increased expression of P-glycoprotein (P-gp was observed in drug resistant Y79 cells; however there was no significant change in the expression of P-gp found between primary cultures of primarily enucleated eyes and PCNC. Multidrug resistance protein 1 (Mrp-1 expression was found to be elevated in the drug resistant Y79 cells as well as in PCNC. No significant change in the expression of lung resistance associated protein (Lrp was observed in the drug resistant Y79 cells as well as in PCNC. CONCLUSION: Our results suggest that multidrug resistant proteins are intrinsically present in retinoblastoma which causes treatment failure in managing retinoblastoma with chemotherapy.

  20. Facial Expression Recognition Through Machine Learning

    Directory of Open Access Journals (Sweden)

    Nazia Perveen

    2015-08-01

    Full Text Available Facial expressions communicate non-verbal cues which play an important role in interpersonal relations. Automatic recognition of facial expressions can be an important element of normal human-machine interfaces it might likewise be utilized as a part of behavioral science and in clinical practice. In spite of the fact that people perceive facial expressions for all intents and purposes immediately solid expression recognition by machine is still a challenge. From the point of view of automatic recognition a facial expression can be considered to comprise of disfigurements of the facial parts and their spatial relations or changes in the faces pigmentation. Research into automatic recognition of the facial expressions addresses the issues encompassing the representation and arrangement of static or dynamic qualities of these distortions or face pigmentation. We get results by utilizing the CVIPtools. We have taken train data set of six facial expressions of three persons and for train data set purpose we have total border mask sample 90 and 30 border mask sample for test data set purpose and we use RST- Invariant features and texture features for feature analysis and then classified them by using k- Nearest Neighbor classification algorithm. The maximum accuracy is 90.