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Sample records for viable design approach

  1. Cybernetically sound organizational structures II: Relating de Sitter's design theory to Beer's viable system model

    NARCIS (Netherlands)

    Achterbergh, J.M.I.M.; Vriens, D.J.

    2011-01-01

    - Purpose – The purpose of this paper is to show how the viable system model (VSM) and de Sitter's design theory can complement each other in the context of the diagnosis and design of viable organizations. - Design/methodology/approach – Key concepts from Beer's model and de Sitter's design

  2. Protein design algorithms predict viable resistance to an experimental antifolate.

    Science.gov (United States)

    Reeve, Stephanie M; Gainza, Pablo; Frey, Kathleen M; Georgiev, Ivelin; Donald, Bruce R; Anderson, Amy C

    2015-01-20

    Methods to accurately predict potential drug target mutations in response to early-stage leads could drive the design of more resilient first generation drug candidates. In this study, a structure-based protein design algorithm (K* in the OSPREY suite) was used to prospectively identify single-nucleotide polymorphisms that confer resistance to an experimental inhibitor effective against dihydrofolate reductase (DHFR) from Staphylococcus aureus. Four of the top-ranked mutations in DHFR were found to be catalytically competent and resistant to the inhibitor. Selection of resistant bacteria in vitro reveals that two of the predicted mutations arise in the background of a compensatory mutation. Using enzyme kinetics, microbiology, and crystal structures of the complexes, we determined the fitness of the mutant enzymes and strains, the structural basis of resistance, and the compensatory relationship of the mutations. To our knowledge, this work illustrates the first application of protein design algorithms to prospectively predict viable resistance mutations that arise in bacteria under antibiotic pressure.

  3. Experimental design for the optimization of propidium monoazide treatment to quantify viable and non-viable bacteria in piggery effluents.

    Science.gov (United States)

    Desneux, Jérémy; Chemaly, Marianne; Pourcher, Anne-Marie

    2015-08-16

    Distinguishing between viable and dead bacteria in animal and urban effluents is a major challenge. Among existing methods, propidium monoazide (PMA)-qPCR is a promising way to quantify viable cells. However, its efficiency depends on the composition of the effluent, particularly on total suspended solids (TSS)) and on methodological parameters. The aim of this study was evaluate the influence of three methodological factors (concentration of PMA, incubation time and photoactivation time) on the efficiency of PMA-qPCR to quantify viable and dead cells of Listeria monocytogenes used as a microorganism model, in two piggery effluents (manure and lagoon effluent containing 20 and 0.4 TSS g.kg(-1), respectively). An experimental design strategy (Doehlert design and desirability function) was used to identify the experimental conditions to achieve optimal PMA-qPCR results. The quantification of viable cells of L. monocytogenes was mainly influenced by the concentration of PMA in the manure and by the duration of photoactivation in the lagoon effluent. Optimal values differed with the matrix: 55 μM PMA, 5 min incubation and 56 min photoactivation for manure and 20 μM PMA, 20 min incubation and 30 min photoactivation for lagoon effluent. Applied to five manure and four lagoon samples, these conditions resulted in satisfactory quantification of viable and dead cells. PMA-qPCR can be used on undiluted turbid effluent with high levels of TSS, provided preliminary tests are performed to identify the optimal conditions.

  4. Designing viable cropping options for salt-affected lands

    Science.gov (United States)

    Shabala, Sergey; Meinke, Holger

    2017-04-01

    Salinity cost agricultural sector over 27Bln pa in lost opportunities and is an issue that crosses all spatial and temporal scales - from individual fields, farms, catchments, landscapes to national and global levels. Salinity manifests itself in many forms and often leads to further soil degradation such as erosion, nutrient and soil organic matter depletion, and a loss of (soil) biodiversity. Salinity may also cause major disturbance to ecosystems due to its impact on resources (e.g. pollution of aquifers). In extreme cases it can turn previously highly productive areas into wastelands. An increasing global population and unprecedented urban sprawls are now putting additional pressures on our soil and water resources, particularly in regions where urbanisation directly competes with agriculture for access to land and water. And although everyone agrees that avoiding soil salinity in the first instance would be the most effective way of combating it, reality is that the amount of saline land and water resources is rapidly increasing, and will continue to increase, especially in developing countries. Purposefully designing our cropping systems that can cope with various levels of salinity could be one answer to this increasing problem. In this work we review some of the key cropping options that can be deployed to either avoid, reduce or remediate salt-affected lands. We argue that for these measures to be most effective an ongoing science - policy - society dialogue is required to ensure that policy frameworks that govern land and water management are conducive to reducing salinity or even assist in restoring affected areas. We first consider several case studies highlighting the extent of the problem using ongoing salinity hotspots around the globe. We then look at halophytes as a possible biological tools to remediate already saline sols, and discuss prospects of mixed (halophytes and glycophytes) cropping solutions for various agricultural systems at different

  5. Zero based programming: a viable security budgeting approach.

    Science.gov (United States)

    Roll, Frederick G

    2003-01-01

    To get additional dollars or avoid budget cuts or personnel reductions, healthcare security directors should consider a budget approach that best justifies the needs of the department or organization.

  6. Enabling Strategy Formulation by ICT: A Viable Systems Approach

    NARCIS (Netherlands)

    Vriens, D.J.; Achterbergh, J.M.I.M.

    2004-01-01

    In this chapter the role of ICT for competitive intelligence is approached from the perspective of strategy formulation. The authors hold the view that competitive intelligence can be seen as knowledge necessary for the process of strategy formulation. To determine the role of ICT, it is proposed to

  7. Slurry pipeline design approach

    Energy Technology Data Exchange (ETDEWEB)

    Betinol, Roy; Navarro R, Luis [Brass Chile S.A., Santiago (Chile)

    2009-12-19

    Compared to other engineering technologies, the design of a commercial long distance Slurry Pipeline design is a relatively new engineering concept which gained more recognition in the mid 1960 's. Slurry pipeline was first introduced to reduce cost in transporting coal to power generating units. Since then this technology has caught-up worldwide to transport other minerals such as limestone, copper, zinc and iron. In South America, the use of pipeline is commonly practiced in the transport of Copper (Chile, Peru and Argentina), Iron (Chile and Brazil), Zinc (Peru) and Bauxite (Brazil). As more mining operations expand and new mine facilities are opened, the design of the long distance slurry pipeline will continuously present a commercially viable option. The intent of this paper is to present the design process and discuss any new techniques and approach used today to ensure a better, safer and economical slurry pipeline. (author)

  8. Molecular approaches for viable bacterial population and transcriptional analyses in a rodent model of dental caries.

    Science.gov (United States)

    Klein, M I; Scott-Anne, K M; Gregoire, S; Rosalen, P L; Koo, H

    2012-10-01

    Culturing methods are the primary approach for microbiological analysis of plaque biofilms in rodent models of dental caries. In this study, we developed strategies for the isolation of DNA and RNA from plaque biofilms formed in vivo to analyse the viable bacterial population and gene expression. Plaque biofilm samples from rats were treated with propidium monoazide to isolate DNA from viable cells, and the purified DNA was used to quantify total bacteria and the Streptococcus mutans population via quantitative polymerase chain reaction (qPCR) and specific primers; the same samples were also analysed by counting colony-forming units (CFU). In parallel, RNA was isolated from plaque-biofilm samples (from the same animals) and used for transcriptional analyses via reverse transcription-qPCR. The viable populations of both S. mutans and total bacteria assessed by qPCR were positively correlated with the CFU data (P  0.8). However, the qPCR data showed higher bacterial cell counts, particularly for total bacteria (vs. CFU). Moreover, S. mutans proportion in the plaque biofilm determined by qPCR analysis showed strong correlation with incidence of smooth-surface caries (P = 0.0022, r = 0.71). The purified RNAs presented high RNA integrity numbers (> 7), which allowed measurement of the expression of genes that are critical for S. mutans virulence (e.g. gtfB and gtfC). Our data show that the viable microbial population and the gene expression can be analysed simultaneously, providing a global assessment of the infectious aspect of dental caries. Our approach could enhance the value of the current rodent model in further understanding the pathophysiology of this disease and facilitating the exploration of novel anti-caries therapies. © 2012 John Wiley & Sons A/S.

  9. Novel Approach for Enterocutaneous Fistula Treatment with the Use of Viable Cryopreserved Placental Membrane

    Directory of Open Access Journals (Sweden)

    Frederick Nichols

    2016-01-01

    Full Text Available Enterocutaneous fistulas (ECF are a difficult and costly surgical complication to manage. The standard treatment of nil per os (NPO and total paraenteral nutrition (TPN is not well tolerated by patients. TPN is also known for complications associated with long term central venous catheterization and for high cost of prolonged hospital stay. We present two low output ECF cases successfully treated with viable cryopreserved placental membrane (vCPM placed into the fistula tracts. One patient is a 59-year-old male with a low output ECF from a jejunostomy tube site four weeks after the surgery. The second patient is an 87-year-old male with a low output ECF following a small bowel resection secondary to a strangulated inguinal hernia. He was evaluated on day 41 after surgery. NPO and TPN for several weeks did not resolute the ECF. The fistulae were closed postoperatively in both patients with zero output on the same day after one vCPM application. On day 3 postoperatively both patients were started on clear liquid diets and subsequently advanced to regular diets. The ECF have remained resolved for over 2 months. The use of vCPM is a novel promising approach for treatment of ECF.

  10. Teaching Writing within the Disciplines: A Viable Approach for English for Academic Purposes (EAP) Instructors

    Science.gov (United States)

    Leopold, Lisa

    2011-01-01

    This case study of an adjunct-model English for Academic Purposes (EAP) writing course linked to a policy-analysis course describes an effective approach for putting "specificity" into practice in EAP curriculum design. The rationale for interdisciplinary collaboration, the positive learning outcomes from the EAP writing course, the…

  11. Articulating Design Approaches?

    DEFF Research Database (Denmark)

    Kensing, Finn; Bødker, Keld; Simonsen, Jesper

    We are working on an approach for designing CSCW systems since we advocate the importance of generalizing from own work practice as designers and from studies of designers working under industrial conditions. We use the term approach as something in between commodified methods and isolated techni...

  12. From Prototype to Product: Making Participatory Design of mHealth Commercially Viable.

    Science.gov (United States)

    Andersen, Tariq O; Bansler, Jørgen P; Kensing, Finn; Moll, Jonas

    2017-01-01

    This paper delves into the challenges of engaging patients, clinicians and industry stakeholders in the participatory design of an mHealth platform for patient-clinician collaboration. It follows the process from the development of a research prototype to a commercial software product. In particular, we draw attention to four major challenges of (a) aligning the different concerns of patients and clinicians, (b) designing according to clinical accountability, (c) ensuring commercial interest, and (d) dealing with regulatory constraints when prototyping safety critical health Information Technology. Using four illustrative cases, we discuss what these challenges entail and the implications they pose to Participatory Design. We conclude the paper by presenting lessons learned.

  13. In acceptance we trust? Conceptualising acceptance as a viable approach to NGO security management.

    Science.gov (United States)

    Fast, Larissa A; Freeman, C Faith; O'Neill, Michael; Rowley, Elizabeth

    2013-04-01

    This paper documents current understanding of acceptance as a security management approach and explores issues and challenges non-governmental organisations (NGOs) confront when implementing an acceptance approach to security management. It argues that the failure of organisations to systematise and clearly articulate acceptance as a distinct security management approach and a lack of organisational policies and procedures concerning acceptance hinder its efficacy as a security management approach. The paper identifies key and cross-cutting components of acceptance that are critical to its effective implementation in order to advance a comprehensive and systematic concept of acceptance. The key components of acceptance illustrate how organisational and staff functions affect positively or negatively an organisation's acceptance, and include: an organisation's principles and mission, communications, negotiation, programming, relationships and networks, stakeholder and context analysis, staffing, and image. The paper contends that acceptance is linked not only to good programming, but also to overall organisational management and structures. © 2013 The Author(s). Journal compilation © Overseas Development Institute, 2013.

  14. A simple approach for making a viable, safe, and high-performances lithium-sulfur battery

    Science.gov (United States)

    Carbone, Lorenzo; Coneglian, Thomas; Gobet, Mallory; Munoz, Stephen; Devany, Matthew; Greenbaum, Steve; Hassoun, Jusef

    2018-02-01

    We report an electrolyte with low flammability, based on diethylene glycol dimethyl ether (DEGDME) dissolving lithium bis-trifluoromethane sulfonimidate (LiTFSI), and lithium nitrate (LiNO3) for high-performances lithium/sulfur battery. Self-diffusion coefficients, conductivity, and lithium transport number of the electrolyte are obtained by nuclear magnetic resonance and electrochemical impedance spectroscopy. Interface stability, lithium stripping/deposition ability, and the electrochemical stability window of the electrolyte are determined by voltammetry and impedance spectroscopy. The tests suggest conductivity higher than 10-2 S cm-1, lithium transport number of about 0.5, electrochemical stability extending from 0 V to 4.6 V, and excellent compatibility with lithium metal. A composite cathode using sulfur and multi walled carbon nanotubes (MWCNTs) is characterized in terms of structure and morphology by X-ray diffraction and scanning electron microscopy. The study shows spherical flakes in which the carbon nanotubes protect the crystalline sulfur from excessive dissolution, and create the optimal host for allowing the proper cell operation. The Li/S cell reveals highly reversible process during charge/discharge cycles, fast kinetic, and lithium diffusion coefficient in the sulfur electrode ranging from 10-12 to 10-10 cm2 s-1. The cell evidences a coulombic efficiency approaching 100%, capacity from 1300 mAh g-1 to 900 mAh g-1 and practical energy density higher than 400 Wh kg-1.

  15. Dual Mode Offering As Viable Approach 
For Promotion Of Higher Education In Pakistan

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    Irshad HUSSAIN

    2014-01-01

    Full Text Available Pakistan is a developing with 148 universities and degree awarding institutions including public and private sector. The enrolment as given in the National Educational Policy 2009 was up to 5% only. It reflects greater demands of higher/tertiary education and calls for alternative strategic measures for addressing the issue. An innovative approach was necessary to address the issue of access. Therefore, the Islamia University of Bahawalpur –a formal mode university took an innovative initiative to become a dual mode university by establishing an Institute of Distance Education (IDE in 2011. The institute offered along with others, an M.Phill programme in ten disciplines through distance education mode in semester fall 2011. More than eight hundred applications were received by potential learners against 275 seats. However, after test and interview 189 students were enrolled in M.Phill programme in Applied Psychology, Arabic, Education, English, Media Studies, Islamic Studies, Pakistan Studies, History, Persian, and Urdu. In the beginning, the Institute organized an orientation workshop for learners to guide them studying in distance education system. The programme was offered under semester system and the semester was broke up into two halves –mid-term and final term. The respective departments provided learning materials to students whereas the IDE provided instructional booklet. Submission of two assignments was compulsory for the entire semester; one before mid-term and second before final-term workshop/ examination for each of the courses. Similarly, students’ presence in workshops for 24 hours (12 during mid-term and 12 during final-term workshop for one 3-credit hour course was mandatory. Students’ support services were provided through Skype conference, social media and mobile phones. Students necessarily had to give presentations and submit their assignments after checking their similarity index by using turnitin software. At the

  16. DUAL MODE OFFERING AS VIABLE APPROACH FOR PROMOTION OF HIGHER EDUCATION IN PAKISTAN

    Directory of Open Access Journals (Sweden)

    Irshad HUSSAIN

    2014-07-01

    Full Text Available Pakistan is a developing with 148 universities and degree awarding institutions including public and private sector. The enrolment as given in the National Educational Policy 2009 was up to 5% only. It reflects greater demands of higher/tertiary education and calls for alternative strategic measures for addressing the issue. An innovative approach was necessary to address the issue of access. Therefore, the Islamia University of Bahawalpur –a formal mode university took an innovative initiative to become a dual mode university by establishing an Institute of Distance Education (IDE in 2011. The institute offered along with others, an M.Phill programme in ten disciplines through distance education mode in semester fall 2011. More than eight hundred applications were received by potential learners against 275 seats. However, after test and interview 189 students were enrolled in M.Phill programme in Applied Psychology, Arabic, Education, English, Media Studies, Islamic Studies, Pakistan Studies, History, Persian, and Urdu. In the beginning, the Institute organized an orientation workshop for learners to guide them studying in distance education system. The programme was offered under semester system and the semester was broke up into two halves –mid-term and final term. The respective departments provided learning materials to students whereas the IDE provided instructional booklet. Submission of two assignments was compulsory for the entire semester; one before mid-term and second before final-term workshop/ examination for each of the courses. Similarly, students’ presence in workshops for 24 hours (12 during mid-term and 12 during final-term workshop for one 3-credit hour course was mandatory. Students’ support services were provided through Skype conference, social media and mobile phones. Students necessarily had to give presentations and submit their assignments after checking their similarity index by using turnitin software. At the

  17. Holistic approach to production systems from the perspective of lean manufacturing and viable systems model; Aproximacion holistica a los sistemas de produccion desde la perspectiva Lean Manufacturing y Modelos de Sistemas Viables

    Energy Technology Data Exchange (ETDEWEB)

    Puche Regaliza, J. C.; Costas Gual, J.

    2012-07-01

    The reductionism approach usually adopted by many organizations provokes too often a problem of sustain ability in the market over time in these organizations. To increase this sustain ability, we propose a structural and a behavioral change, in a way that the reductionism is replaced by an holistic approach appropriate to address the dynamic complexity inherent in any organization. With regard to structural change, we propose the use of Organizational Cybernetics and particularly the Viable System Model. With respect to behavior change, we propose the use of Lean Manufacturing paradigm. (Author)

  18. Circular permutation prediction reveals a viable backbone disconnection for split proteins: an approach in identifying a new functional split intein.

    Directory of Open Access Journals (Sweden)

    Yun-Tzai Lee

    Full Text Available Split-protein systems have emerged as a powerful tool for detecting biomolecular interactions and reporting biological reactions. However, reliable methods for identifying viable split sites are still unavailable. In this study, we demonstrated the feasibility that valid circular permutation (CP sites in proteins have the potential to act as split sites and that CP prediction can be used to search for internal permissive sites for creating new split proteins. Using a protein ligase, intein, as a model, CP predictor facilitated the creation of circular permutants in which backbone opening imposes the least detrimental effects on intein folding. We screened a series of predicted intein CPs and identified stable and native-fold CPs. When the valid CP sites were introduced as split sites, there was a reduction in folding enthalpy caused by the new backbone opening; however, the coincident loss in entropy was sufficient to be compensated, yielding a favorable free energy for self-association. Since split intein is exploited in protein semi-synthesis, we tested the related protein trans-splicing (PTS activities of the corresponding split inteins. Notably, a novel functional split intein composed of the N-terminal 36 residues combined with the remaining C-terminal fragment was identified. Its PTS activity was shown to be better than current reported two-piece intein with a short N-terminal segment. Thus, the incorporation of in silico CP prediction facilitated the design of split intein as well as circular permutants.

  19. Managing Viable Knowledge

    NARCIS (Netherlands)

    Achterbergh, J.M.I.M.; Vriens, D.J.

    2002-01-01

    In this paper, Beer's Viable System Model (VSM) is applied to knowledge management. Based on the VSM, domains of knowledge are identified that an organization should possess to maintain its viability. The logic of the VSM is also used to support the diagnosis, design and implementation of the

  20. Experimental design a chemometric approach

    CERN Document Server

    Deming, SN

    1987-01-01

    Now available in a paperback edition is a book which has been described as ``...an exceptionally lucid, easy-to-read presentation... would be an excellent addition to the collection of every analytical chemist. I recommend it with great enthusiasm.'' (Analytical Chemistry). Unlike most current textbooks, it approaches experimental design from the point of view of the experimenter, rather than that of the statistician. As the reviewer in `Analytical Chemistry' went on to say: ``Deming and Morgan should be given high praise for bringing the principles of experimental design to the level of the p

  1. Design approaches to experimental mediation.

    Science.gov (United States)

    Pirlott, Angela G; MacKinnon, David P

    2016-09-01

    Identifying causal mechanisms has become a cornerstone of experimental social psychology, and editors in top social psychology journals champion the use of mediation methods, particularly innovative ones when possible (e.g. Halberstadt, 2010, Smith, 2012). Commonly, studies in experimental social psychology randomly assign participants to levels of the independent variable and measure the mediating and dependent variables, and the mediator is assumed to causally affect the dependent variable. However, participants are not randomly assigned to levels of the mediating variable(s), i.e., the relationship between the mediating and dependent variables is correlational. Although researchers likely know that correlational studies pose a risk of confounding, this problem seems forgotten when thinking about experimental designs randomly assigning participants to levels of the independent variable and measuring the mediator (i.e., "measurement-of-mediation" designs). Experimentally manipulating the mediator provides an approach to solving these problems, yet these methods contain their own set of challenges (e.g., Bullock, Green, & Ha, 2010). We describe types of experimental manipulations targeting the mediator (manipulations demonstrating a causal effect of the mediator on the dependent variable and manipulations targeting the strength of the causal effect of the mediator) and types of experimental designs (double randomization, concurrent double randomization, and parallel), provide published examples of the designs, and discuss the strengths and challenges of each design. Therefore, the goals of this paper include providing a practical guide to manipulation-of-mediator designs in light of their challenges and encouraging researchers to use more rigorous approaches to mediation because manipulation-of-mediator designs strengthen the ability to infer causality of the mediating variable on the dependent variable.

  2. Mutual coupling of hydrologic and hydrodynamic models - a viable approach for improved large-scale inundation estimates?

    Science.gov (United States)

    Hoch, Jannis; Winsemius, Hessel; van Beek, Ludovicus; Haag, Arjen; Bierkens, Marc

    2016-04-01

    Due to their increasing occurrence rate and associated economic costs, fluvial floods are large-scale and cross-border phenomena that need to be well understood. Sound information about temporal and spatial variations of flood hazard is essential for adequate flood risk management and climate change adaption measures. While progress has been made in assessments of flood hazard and risk on the global scale, studies to date have made compromises between spatial resolution on the one hand and local detail that influences their temporal characteristics (rate of rise, duration) on the other. Moreover, global models cannot realistically model flood wave propagation due to a lack of detail in channel and floodplain geometry, and the representation of hydrologic processes influencing the surface water balance such as open water evaporation from inundated water and re-infiltration of water in river banks. To overcome these restrictions and to obtain a better understanding of flood propagation including its spatio-temporal variations at the large scale, yet at a sufficiently high resolution, the present study aims to develop a large-scale modeling tool by coupling the global hydrologic model PCR-GLOBWB and the recently developed hydrodynamic model DELFT3D-FM. The first computes surface water volumes which are routed by the latter, solving the full Saint-Venant equations. With DELFT3D FM being capable of representing the model domain as a flexible mesh, model accuracy is only improved at relevant locations (river and adjacent floodplain) and the computation time is not unnecessarily increased. This efficiency is very advantageous for large-scale modelling approaches. The model domain is thereby schematized by 2D floodplains, being derived from global data sets (HydroSHEDS and G3WBM, respectively). Since a previous study with 1way-coupling showed good model performance (J.M. Hoch et al., in prep.), this approach was extended to 2way-coupling to fully represent evaporation

  3. Ancient Climatic Architectural Design Approach

    Directory of Open Access Journals (Sweden)

    Nasibeh Faghih

    2013-01-01

    Full Text Available Ancient climatic architecture had found out a series of appropriate responses for the best compatibility with the critical climate condition for instance, designing ‘earth sheltered houses’ and ‘courtyard houses’. They could provide human climatic comfort without excessive usage of fossil fuel resources. Owing to the normal thermal conditions in the ground depth, earth sheltered houses can be slightly affected by thermal fluctuations due to being within the earth. In depth further than 6.1 meters, temperature alternation is minute during the year, equaling to average annual temperature of outside. More to the point, courtyard buildings as another traditional design approach, have prepared controlled climatic space based on creating the maximum shade in the summer and maximum solar heat absorption in the winter. The courtyard houses served the multiple functions of lighting to the rooms, acting as a heat absorber in the summer and a radiator in the winter, as well as providing an open space inside for community activities. It must be noted that they divided into summer and winter zones located in south and north of the central courtyard where residents were replaced into them according to changing the seasons. Therefore, Ancient climatic buildings provided better human thermal comfort in comparison with the use contemporary buildings of recent years, except with the air conditioning

  4. A Participatory Design Approach to Develop an Interactive Sound Environment Simulator.

    Science.gov (United States)

    Hanssen, Geir K; Dahl, Yngve

    2016-10-01

    Our purpose is to provide insight into the added value of applying a participatory design approach in the design of an interactive sound environment simulator to facilitate communication and understanding between patients and audiologists in consultation situations. We have applied a qualitative approach, presenting results and discussion in the form of a story, following 3 consecutive steps: problem investigation, design, and evaluation. We provide an overview of lessons learned, emphasizing how patients and audiologists took roles and responsibilities in the design process and the effects of this involvement. Our results suggest that participatory design is a viable and practical approach to address multifaceted problems directly affecting patients and practitioners.

  5. Designing primers and evaluation of the efficiency of propidium monoazide – Quantitative polymerase chain reaction for counting the viable cells of Lactobacillus gasseri and Lactobacillus salivarius

    Directory of Open Access Journals (Sweden)

    Chieh-Hsien Lai

    2017-07-01

    Full Text Available The purpose of this study is to evaluate the efficiency of using propidium monoazide (PMA real-time quantitative polymerase chain reaction (qPCR to count the viable cells of Lactobacillus gasseri and Lactobacillus salivarius in probiotic products. Based on the internal transcription spacer and 23S rRNA genes, two primer sets specific for these two Lactobacillus species were designed. For a probiotic product, the total deMan Rogosa Sharpe plate count was 8.65±0.69 log CFU/g, while for qPCR, the cell counts of L. gasseri and L. salivarius were 8.39±0.14 log CFU/g and 8.57±0.24 log CFU/g, respectively. Under the same conditions, for its heat-killed product, qPCR counts for L. gasseri and L. salivarius were 6.70±0.16 log cells/g and 7.67±0.20 log cells/g, while PMA-qPCR counts were 5.33±0.18 log cells/g and 5.05±0.23 log cells/g, respectively. For cell dilutions with a viable cell count of 8.5 log CFU/mL for L. gasseri and L. salivarius, after heat killing, the PMA-qPCR count for both Lactobacillus species was near 5.5 log cells/mL. When the PMA-qPCR counts of these cell dilutions were compared before and after heat killing, although some DNA might be lost during the heat killing, significant qPCR signals from dead cells, i.e., about 4–5 log cells/mL, could not be reduced by PMA treatment. Increasing PMA concentrations from 100 μM to 200 μM or light exposure time from 5 minutes to 15 minutes had no or, if any, only minor effect on the reduction of qPCR signals from their dead cells. Thus, to differentiate viable lactic acid bacterial cells from dead cells using the PMA-qPCR method, the efficiency of PMA to reduce the qPCR signals from dead cells should be notable.

  6. Designing primers and evaluation of the efficiency of propidium monoazide - Quantitative polymerase chain reaction for counting the viable cells of Lactobacillus gasseri and Lactobacillus salivarius.

    Science.gov (United States)

    Lai, Chieh-Hsien; Wu, Sih-Rong; Pang, Jen-Chieh; Ramireddy, Latha; Chiang, Yu-Cheng; Lin, Chien-Ku; Tsen, Hau-Yang

    2017-07-01

    The purpose of this study is to evaluate the efficiency of using propidium monoazide (PMA) real-time quantitative polymerase chain reaction (qPCR) to count the viable cells of Lactobacillus gasseri and Lactobacillus salivarius in probiotic products. Based on the internal transcription spacer and 23S rRNA genes, two primer sets specific for these two Lactobacillus species were designed. For a probiotic product, the total deMan Rogosa Sharpe plate count was 8.65±0.69 log CFU/g, while for qPCR, the cell counts of L. gasseri and L. salivarius were 8.39±0.14 log CFU/g and 8.57±0.24 log CFU/g, respectively. Under the same conditions, for its heat-killed product, qPCR counts for L. gasseri and L. salivarius were 6.70±0.16 log cells/g and 7.67±0.20 log cells/g, while PMA-qPCR counts were 5.33±0.18 log cells/g and 5.05±0.23 log cells/g, respectively. For cell dilutions with a viable cell count of 8.5 log CFU/mL for L. gasseri and L. salivarius, after heat killing, the PMA-qPCR count for both Lactobacillus species was near 5.5 log cells/mL. When the PMA-qPCR counts of these cell dilutions were compared before and after heat killing, although some DNA might be lost during the heat killing, significant qPCR signals from dead cells, i.e., about 4-5 log cells/mL, could not be reduced by PMA treatment. Increasing PMA concentrations from 100 μM to 200 μM or light exposure time from 5 minutes to 15 minutes had no or, if any, only minor effect on the reduction of qPCR signals from their dead cells. Thus, to differentiate viable lactic acid bacterial cells from dead cells using the PMA-qPCR method, the efficiency of PMA to reduce the qPCR signals from dead cells should be notable. Copyright © 2016. Published by Elsevier B.V.

  7. Organizational design approaches in management consulting

    NARCIS (Netherlands)

    Visscher, Klaasjan; Visscher-Voerman, Irene

    2010-01-01

    Purpose: The purpose of this paper is to map the variety in organizational design approaches, to clarify their differences, and to find out what constitutes good designing in practice. - Design/methodology/approach: A series of in-depth interviews with experienced, high-reputation consultants is

  8. Quality of life, coping strategies and support needs of women seeking Traditional Chinese Medicine for infertility and viable pregnancy in Australia: a mixed methods approach.

    Science.gov (United States)

    Ried, Karin; Alfred, Ann

    2013-04-09

    Infertility affects about 15% of couples in Western-societies with most progressing to fertility clinics for treatment. Despite being common, infertility is often experienced as a lonely road for affected couples. In this paper we expand on our previously published findings of women's experiences with infertility or difficulty of viable pregnancy who had sought Traditional Chinese Medicine (TCM) therapy in Australia, and focus on women's quality of life, coping strategies, and support needs. We applied mixed methods using the Tuebingen Quality of Life and the COPE questionnaires and in-depth interviews with 25 women with primary or secondary infertility, recurrent miscarriages or unexplained stillbirth, and who had consulted a TCM practitioner. We used a thematic approach to analyse the interviews, and descriptive statistics to evaluate questionnaire responses. Women reported through both questionnaires and interviews compromised quality of life due to the high level of distress, guilt, grief, and frustration caused by infertility. However, our women represented a highly motivated sample, actively seeking alternative support. While the TCM approach to infertility management increased women's sense of personal agency and control through education and continuity of care, the need for greater understanding and support on a societal level remains. In infertility, ongoing emotional and instrumental support is pivotal to the wellbeing and quality of life of the affected. Traditional Chinese Medicine addresses some support needs in infertility not routinely available in the Western model of care. More peer-led and professional-led support groups are greatly needed for women experiencing infertility to help break isolation and raise awareness of integrative approaches to fertility management.

  9. Highlights in mechatronic design approaches

    NARCIS (Netherlands)

    Dertien, Edwin Christian; Stramigioli, Stefano; Zangh, Dan; Wei, Bin

    2017-01-01

    In the recent years a major change in the engineering process of mechatronics and robotics has taken place. In various design oriented laboratories around the world a shift can be recognised from a focus on analysis, simulation and modelling combined with outsourcing hardware design to the use of

  10. Organization design the collaborative approach

    CERN Document Server

    Stanford, Naomi

    2005-01-01

    Organization Design looks at how you need to change the ways your organization does things in order to increase productivity, performance, and profit. Providing the knowledge and method to handle the kind of recurring organisational change that all businesses face, those which do not involve transforming the entire enterprise but which necessitate significant change at the business unit, divisional, functional, facility or local levels. The problem lies in knowing what needs to change and how to change it. Taking the organisation as a designed system, it describes four major elements of organizations: the work - the basic tasks to be done by the organisation and its parts, the people - characteristics of individuals in the organization, formal organization - structures eg the organisation hierarchy, processes, and methods that are formally created to get individuals to perform tasks, informal organization - emerging arrangements including variations to the norm, processes, and relationships, commonly describe...

  11. Plasticity Approach to Shear Design

    DEFF Research Database (Denmark)

    Hoang, Cao Linh; Nielsen, Mogens Peter

    1998-01-01

    The paper presents some plastic models for shear design of reinforced concrete beams. Distinction is made between two shear failure modes, namely web crushing and crack sliding. The first mentioned mode is met in beams with large shear reinforcement degrees. The mode of crack sliding is met in non...... in uncracked concrete. Good agree between theory and tests has been found.Keywords: dsign, plasticity, reinforced concrete, reinforcement, shear, web crushing....

  12. An Emerging Approach to Systems Design

    DEFF Research Database (Denmark)

    Kensing, Finn; Bødker, Keld; Simonsen, Jesper

    The paper presents our first attempt to formulate a design approach based upon our experiences from nine design projects in various organizations. In the projects we have experimented with techniques for analyzing the needs of the organization in question and for supporting the design process. Th...

  13. Nonstationary Approaches to Hydrologic Design

    Science.gov (United States)

    Vogel, Richard; Hecht, Jory; Read, Laura

    2014-05-01

    We introduce a generalized framework for evaluating the risk, reliability and return period of hydrologic events in a nonstationary world. A heteroscedastic regression model is introduced as an elegant and general framework for modeling trends in the mean and/or variance of hydrologic records using ordinary least squares regression methods. A regression approach to modeling trends has numerous advantages over other methods including: (1) ease of application, (2) considers linear or nonlinear trends, (3) graphical display of trends, (4) analytical estimate of the power of the trend test and prediction intervals associated with trend extrapolation. Traditional statements of risk, reliability and return periods which assume that the annual probability of a flood event remains constant throughout the project horizon are revised to include the impacts of trends in the mean and/or variance of hydrologic records. Our analyses reveal that in a nonstationary world, meaningful expressions of the likelihood of future hydrologic events are unlikely to result from knowledge of return periods whereas knowledge of system reliability over future planning horizons can effectively communicate the likelihood of future hydrologic events of interest.

  14. Experimental design research approaches, perspectives, applications

    CERN Document Server

    Stanković, Tino; Štorga, Mario

    2016-01-01

    This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e.g. psychology, cognition, sociology, computer science, management). Above all, the book emphasizes the integrative nature of design research in terms of the methods, theories, and units of study—from the individual to the organizational level. Although this approach offers many advantages, it has inherently led to a situation in current research practice where methods are diverging and integration between individual, team and organizational under...

  15. An architectural approach to level design

    CERN Document Server

    Totten, Christopher W

    2014-01-01

    Explore Level Design through the Lens of Architectural and Spatial Experience TheoryWritten by a game developer and professor trained in architecture, An Architectural Approach to Level Design is one of the first books to integrate architectural and spatial design theory with the field of level design. It explores the principles of level design through the context and history of architecture, providing information useful to both academics and game development professionals.Understand Spatial Design Principles for Game Levels in 2D, 3D, and Multiplayer ApplicationsThe book presents architectura

  16. Beyond (eco)design : Current approaches to sustainable packaging design

    NARCIS (Netherlands)

    Wever, R.

    2014-01-01

    Packaging has always received a lot of attention within the field of design for sustainability. The classical approach has been to mainly focus on reducing the impact of the packaging. This approach stems from the ill-informed position that packaging is superfluous, or at best there only for

  17. Beyond (eco)design : Current approaches to sustainable packaging design

    NARCIS (Netherlands)

    Wever, R.

    Packaging has always received a lot of attention within the field of design for sustainability. The classical approach has been to mainly focus on reducing the impact of the packaging. This approach stems from the ill-informed position that packaging is superfluous, or at best there only for

  18. Beyond (eco)design: current approaches to sustainable packaging design

    OpenAIRE

    Wever, R

    2014-01-01

    Packaging has always received a lot of attention within the field of design for sustainability. The classical approach has been to mainly focus on reducing the impact of the packaging. This approach stems from the ill-informed position that packaging is superfluous, or at best there only for marketing reasons. This is a rather guild-based approach that, if taken to extremes, would lead to complete elimination of packaging, or at most a quintessential brown paper bag. In industry reality thoug...

  19. Design optimization for cost and quality: The robust design approach

    Science.gov (United States)

    Unal, Resit

    1990-01-01

    Designing reliable, low cost, and operable space systems has become the key to future space operations. Designing high quality space systems at low cost is an economic and technological challenge to the designer. A systematic and efficient way to meet this challenge is a new method of design optimization for performance, quality, and cost, called Robust Design. Robust Design is an approach for design optimization. It consists of: making system performance insensitive to material and subsystem variation, thus allowing the use of less costly materials and components; making designs less sensitive to the variations in the operating environment, thus improving reliability and reducing operating costs; and using a new structured development process so that engineering time is used most productively. The objective in Robust Design is to select the best combination of controllable design parameters so that the system is most robust to uncontrollable noise factors. The robust design methodology uses a mathematical tool called an orthogonal array, from design of experiments theory, to study a large number of decision variables with a significantly small number of experiments. Robust design also uses a statistical measure of performance, called a signal-to-noise ratio, from electrical control theory, to evaluate the level of performance and the effect of noise factors. The purpose is to investigate the Robust Design methodology for improving quality and cost, demonstrate its application by the use of an example, and suggest its use as an integral part of space system design process.

  20. The Functional Approach to Curriculum Design.

    Science.gov (United States)

    Yalden, Janice

    1979-01-01

    Reviews Wilkins' approach to curriculum design as presented in his "Notional Syllabuses." Discusses three components of the language teaching-language learning process: the semantic, the functional, and the formal component, showing how Wilkins' analytic approach implies a semantic rather than a grammatical syllabus, based on learners'…

  1. Project Management Approaches for Online Learning Design

    Science.gov (United States)

    Eby, Gulsun; Yuzer, T. Volkan

    2013-01-01

    Developments in online learning and its design are areas that continue to grow in order to enhance students' learning environments and experiences. However, in the implementation of new technologies, the importance of properly and fairly overseeing these courses is often undervalued. "Project Management Approaches for Online Learning Design"…

  2. A RATIONAL APPROACH TO SEPTIC TANK DESIGN

    African Journals Online (AJOL)

    2012-03-01

    Mar 1, 2012 ... A Rational Approach to Septic Tank Design. 69. Table 1: Schedule of Septic Tank Sizing and Dimensions (PWD, 1943). ... ficiency, hence three classes of plan specifications will be included in the evolving design .... 15 people in a typical Nigerian middle class city, say Enugu. It is required to construct a ...

  3. An Automated Approach to Instructional Design Guidance.

    Science.gov (United States)

    Spector, J. Michael; And Others

    This paper describes the Guided Approach to Instructional Design Advising (GAIDA), an automated instructional design tool that incorporates techniques of artificial intelligence. GAIDA was developed by the U.S. Air Force Armstrong Laboratory to facilitate the planning and production of interactive courseware and computer-based training materials.…

  4. Sustainable Supply Chain Design: A Configurational Approach

    Science.gov (United States)

    Masoumik, S. Maryam; Raja Ghazilla, Raja Ariffin

    2014-01-01

    Designing the right supply chain that meets the requirements of sustainable development is a significant challenge. Although there are a considerable number of studies on issues relating to sustainable supply chain design (SSCD) in terms of designing the practices, processes, and structures, they have rarely demonstrated how these components can be aligned to form an effective sustainable supply chain (SSC). Considering this gap in the literature, this study adopts the configurational approach to develop a conceptual framework that could configure the components of a SSC. In this respect, a process-oriented approach is utilized to classify and harmonize the design components. A natural-resource-based view (NRBV) is adopted to determine the central theme to align the design components around. The proposed framework presents three types of SSC, namely, efficient SSC, innovative SSC, and reputed SSC. The study culminates with recommendations concerning the direction for future research. PMID:24523652

  5. A Design Approach to Research and a Landscape Approach to Design

    NARCIS (Netherlands)

    Koh, J.

    2010-01-01

    Koh (pp. 91-100) outlines similarities and differences between landscape design and architectural design, as in particular in the modernist period landscape design was influenced a lot by an architectural approach. As landscape design deals with different issues however, it has generated its own

  6. Adapting advanced engineering design approaches to building design. Potential benefits

    NARCIS (Netherlands)

    Böhms, M.

    2006-01-01

    A number of industries continuously progress advancing their design approaches based on the changing market constraints. Examples such as car, ship and airplane manufacturing industries utilize process setups and techniques, that differ significantly from the processes and techniques used by the

  7. HL-20 concept - Design rationale and approach

    Science.gov (United States)

    Ehrlich, Carl F., Jr.

    1993-10-01

    Design approaches for new space transportation systems strive to lower the cost per flight at affordable lifecycle costs in the 2000 plus era. Achieving efficiency in all operational activities is a major goal for all future systems. The key design drivers are adequate margins, the use of airline/aircraft approaches to certification, and ease of maintenance via subsystem accessibility. These goals have driven the design of the Rockwell HL-20 personnel launch system (PLS) concept. The entire system, both the spacecraft and support systems, has been designed for maintainability and producibility in order to minimize life-cycle costs. In these studies, the aircraft/airline approach to aircraft certification and flightworthiness was used. The vehicle and vehicle subsystems are certified one time, and regular maintenance is scheduled to ensure that flightworthiness is maintained throughout the life of the system. The resulting system-design concept described here reflects these goals through design features that facilitate operations, manufacturing, maintenance, and inspection and overhaul.

  8. A practical approach to programmatic assessment design.

    Science.gov (United States)

    Timmerman, A A; Dijkstra, J

    2017-12-01

    Assessment of complex tasks integrating several competencies calls for a programmatic design approach. As single instruments do not provide the information required to reach a robust judgment of integral performance, 73 guidelines for programmatic assessment design were developed. When simultaneously applying these interrelated guidelines, it is challenging to keep a clear overview of all assessment activities. The goal of this study was to provide practical support for applying a programmatic approach to assessment design, not bound to any specific educational paradigm. The guidelines were first applied in a postgraduate medical training setting, and a process analysis was conducted. This resulted in the identification of four steps for programmatic assessment design: evaluation, contextualisation, prioritisation and justification. Firstly, the (re)design process starts with sufficiently detailing the assessment environment and formulating the principal purpose. Key stakeholders with sufficient (assessment) expertise need to be involved in the analysis of strengths and weaknesses and identification of developmental needs. Central governance is essential to balance efforts and stakes with the principal purpose and decide on prioritisation of design decisions and selection of relevant guidelines. Finally, justification of assessment design decisions, quality assurance and external accountability close the loop, to ensure sound underpinning and continuous improvement of the assessment programme.

  9. A Methodical Approach on Conceptual Structural Design

    NARCIS (Netherlands)

    Horikx, M.P.

    2017-01-01

    The subject of this academic research thesis is a methodical approach on the complex problem-solving process of structural conceptual design.
    For this relatively unexplored problem, an exploratory research is conducted by systematically zooming in from the whole to the part and from coarse to

  10. Design and Implementation of Collaborative Research Approaches

    Science.gov (United States)

    Venti, Mike W.; Berger, David E.

    2009-01-01

    This poster reviews the collarborative research approaches that NASA has been designing and implementing for the Integrated Vehicle Health Management (IVHM) Project. The inputs for the technical plan are reviewed, the Research Test and Integration Plan (RTIP) WIKI, is used to create and propose a multi-themed and multi-partner research testing opportunities. The outputs are testing opportunities.

  11. Design approach for granular emulsion mixes (GEMS)

    CSIR Research Space (South Africa)

    Grobler, JE

    1994-10-01

    Full Text Available Granular Emulsion Mixes (GEMS) are used in a wide range or road applications, ranging from low volume roads in developing areas to freeways in developing urban areas. In this paper a dual design approach for granular emulsion mixes (GEMS...

  12. Involving students in experimental design: three approaches.

    Science.gov (United States)

    McNeal, A P; Silverthorn, D U; Stratton, D B

    1998-12-01

    Many faculty want to involve students more actively in laboratories and in experimental design. However, just "turning them loose in the lab" is time-consuming and can be frustrating for both students and faculty. We describe three different ways of providing structures for labs that require students to design their own experiments but guide the choices. One approach emphasizes invertebrate preparations and classic techniques that students can learn fairly easily. Students must read relevant primary literature and learn each technique in one week, and then design and carry out their own experiments in the next week. Another approach provides a "design framework" for the experiments so that all students are using the same technique and the same statistical comparisons, whereas their experimental questions differ widely. The third approach involves assigning the questions or problems but challenging students to design good protocols to answer these questions. In each case, there is a mixture of structure and freedom that works for the level of the students, the resources available, and our particular aims.

  13. Engineering design: A cognitive process approach

    Science.gov (United States)

    Strimel, Greg Joseph

    research objectives of this study. Two independent coders then coded the video/audio recordings and the additional design data using Halfin's (1973) 17 mental processes for technological problem-solving. The results of this study indicated that the participants employed a wide array of mental processes when solving engineering design challenges. However, the findings provide a general analysis of the number of times participants employed each mental process, as well as the amount of time consumed employing the various mental processes through the different stages of the engineering design process. The results indicated many similarities between the students solving the problem, which may highlight voids in current technology and engineering education curricula. Additionally, the findings showed differences between the processes employed by participants that created the most successful solutions and the participants who developed the least effective solutions. Upon comparing and contrasting these processes, recommendations for instructional strategies to enhance a student's capability for solving engineering design problems were developed. The results also indicated that students, when left without teacher intervention, use a simplified and more natural process to solve design challenges than the 12-step engineering design process reported in much of the literature. Lastly, these data indicated that students followed two different approaches to solving the design problem. Some students employed a sequential and logical approach, while others employed a nebulous, solution centered trial-and-error approach to solving the problem. In this study the participants who were more sequential had better performing solutions. Examining these two approaches and the student cognition data enabled the researcher to generate a conceptual engineering design model for the improved teaching and development of engineering design problem solving.

  14. SYSTEMS APPROACH TO DESIGN OF BUILDINGS DESIGNATED FOR DIPLOMATIC MISSIONS

    Directory of Open Access Journals (Sweden)

    Istomin Boris Semenovich

    2012-10-01

    Full Text Available The article covers the design of buildings of diplomatic missions as sophisticated, multi-functional networks of buildings and structures. Their constituents (rooms have up to 100 different options each of which serves a particular function (namely, lobbies, reception areas, guest rooms, halls, dining rooms, offices, flats, toilets, etc. that may be clustered into four functional groups: diplomatic missions, official areas, residential areas, service areas. The systems approach to the process of planning and designing of buildings of diplomatic missions is to attain the following objectives, including functional development of buildings of diplomatic missions, rational arrangement of their constituents and facilities, grouping and zoning, integrity and interrelation of elements of mission buildings. As a result, the proposed approach is to ensure high-quality architectural and structural solutions.

  15. SYSTEMS APPROACH TO DESIGN OF BUILDINGS DESIGNATED FOR DIPLOMATIC MISSIONS

    OpenAIRE

    Istomin Boris Semenovich; Razin Andrey Dionisovich

    2012-01-01

    The article covers the design of buildings of diplomatic missions as sophisticated, multi-functional networks of buildings and structures. Their constituents (rooms) have up to 100 different options each of which serves a particular function (namely, lobbies, reception areas, guest rooms, halls, dining rooms, offices, flats, toilets, etc.) that may be clustered into four functional groups: diplomatic missions, official areas, residential areas, service areas. The systems approach to the p...

  16. A simplified approach to design for assembly

    DEFF Research Database (Denmark)

    Moultrie, James; Maier, Anja

    2014-01-01

    The basic principles of design for assembly (DfA) are well established. This paper presents a short review of the development of DfA approaches before presenting a new tool in which these principles are packaged for use in teams, both in an industrial and an educational context. The fundamental......, feeding and fixing, this process also encourages the team to explore how this relates to the overall assembly flow and specifically the achievement of throughput targets. The novel approach is an improvement to established methods and encompasses an original assessment tool and its delivery process...

  17. New approach to orthopedic implant design

    Energy Technology Data Exchange (ETDEWEB)

    Hollerbach, K; Perfect, S; Martz, H; Ashby, E

    1999-07-03

    This report describes the accomplishments of a three year LDRD project, aimed at developing computational models and methodologies for improving prosthetic joint design. The investigators developed human models as well as prosthetic joint models. Input data came both from high resolution scans performed at Lawrence Livermore National Laboratory (LLNL) and from data provided by collaborators. Results of the approach, in addition to being presented at scientific meetings, are being used to obtain US Food and Drug Administration (FDA) approval in the process of putting new implant designs on the market.

  18. Modelling Approach In Islamic Architectural Designs

    Directory of Open Access Journals (Sweden)

    Suhaimi Salleh

    2014-06-01

    Full Text Available Architectural designs contribute as one of the main factors that should be considered in minimizing negative impacts in planning and structural development in buildings such as in mosques. In this paper, the ergonomics perspective is revisited which hence focuses on the conditional factors involving organisational, psychological, social and population as a whole. This paper tries to highlight the functional and architectural integration with ecstatic elements in the form of decorative and ornamental outlay as well as incorporating the building structure such as wall, domes and gates. This paper further focuses the mathematical aspects of the architectural designs such as polar equations and the golden ratio. These designs are modelled into mathematical equations of various forms, while the golden ratio in mosque is verified using two techniques namely, the geometric construction and the numerical method. The exemplary designs are taken from theSabah Bandaraya Mosque in Likas, Kota Kinabalu and the Sarawak State Mosque in Kuching,while the Universiti Malaysia Sabah Mosque is used for the Golden Ratio. Results show thatIslamic architectural buildings and designs have long had mathematical concepts and techniques underlying its foundation, hence, a modelling approach is needed to rejuvenate these Islamic designs.

  19. The U.S. Department of Education's "Race-Neutral Alternatives in Postsecondary Education: Innovative Approaches to Diversity"--Are They Viable Substitutes for Affirmative Action?

    Science.gov (United States)

    Commission on Civil Rights, Washington, DC.

    On March 28, 2003 the U.S. Department of Education (ED) issued a report titled "Race-Neutral Alternatives in Postsecondary Education: Innovative Approaches to Diversity." The purpose of this report is to describe a number of race-neutral approaches that postsecondary institutions across the United States are using. This staff assessment by the…

  20. Viable But Not Culturable (VBNC) state of Brettanomyces bruxellensis in wine: New insights on molecular basis of VBNC behaviour using a transcriptomic approach.

    Science.gov (United States)

    Capozzi, Vittorio; Di Toro, Maria Rosaria; Grieco, Francesco; Michelotti, Vania; Salma, Mohammad; Lamontanara, Antonella; Russo, Pasquale; Orrù, Luigi; Alexandre, Hervé; Spano, Giuseppe

    2016-10-01

    The spoilage potential of Brettanomyces bruxellensis in wine is strongly connected with the aptitude of this yeast to enter in a Viable But Non Culturable (VBNC) state when exposed to the harsh wine conditions. In this work, we characterized the VBNC behaviour of seven strains of B. bruxellensis representing a regional intraspecific biodiversity, reporting conclusive evidence for the assessment of VBNC as a strain-dependent character. The VBNC behaviour was monitored by fluorescein diacetate staining/flow cytometry for eleven days after addition of 0.4, 0.6, 0.8, 1 and 1.2 mg/L of molecular SO2 (entrance in the VBNC state) and after SO2 removal (exit from the VBNC state). Furthermore, one representative strain was selected and RNA-seq analysis performed after exposure to 1.2 mg/L SO2 and during the recovery phase. 30 and 1634 genes were identified as differentially expressed following VBNC entrance and 'resuscitation', respectively. The results reported strongly suggested that the entrance in the SO2-induced VBNC state in B. bruxellensis is associated with both, sulfite toxicity and oxidative stress response, confirming the crucial role of genes/proteins involved in redox cell homeostasis. Among the genes induced during recovery, the expression of genes involved in carbohydrate metabolism and encoding heat shock proteins, as well as enriched categories including amino acid transport and transporter activity was observed. The evidences of a general repression of genes involved in DNA replication suggest the occurrence of a true resuscitation of cell rather than a simple regrowth. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Using design tools in strategy workshops to co-create viable and value creating business model ideas with relational business-to-business partners

    DEFF Research Database (Denmark)

    Evers, Winie; Sørensen, Kirsten Bonde

    & Snehota (1995), and effective relational participation therefore involves understanding of one’s own and relational partners’ business models, including the value they seek from their network (George and Bock, 2010). But little research focus on how design can reveal dominant mental models and support...

  2. Economically viable large-scale hydrogen liquefaction

    Science.gov (United States)

    Cardella, U.; Decker, L.; Klein, H.

    2017-02-01

    The liquid hydrogen demand, particularly driven by clean energy applications, will rise in the near future. As industrial large scale liquefiers will play a major role within the hydrogen supply chain, production capacity will have to increase by a multiple of today’s typical sizes. The main goal is to reduce the total cost of ownership for these plants by increasing energy efficiency with innovative and simple process designs, optimized in capital expenditure. New concepts must ensure a manageable plant complexity and flexible operability. In the phase of process development and selection, a dimensioning of key equipment for large scale liquefiers, such as turbines and compressors as well as heat exchangers, must be performed iteratively to ensure technological feasibility and maturity. Further critical aspects related to hydrogen liquefaction, e.g. fluid properties, ortho-para hydrogen conversion, and coldbox configuration, must be analysed in detail. This paper provides an overview on the approach, challenges and preliminary results in the development of efficient as well as economically viable concepts for large-scale hydrogen liquefaction.

  3. An engineering design approach to systems biology.

    Science.gov (United States)

    Janes, Kevin A; Chandran, Preethi L; Ford, Roseanne M; Lazzara, Matthew J; Papin, Jason A; Peirce, Shayn M; Saucerman, Jeffrey J; Lauffenburger, Douglas A

    2017-07-17

    Measuring and modeling the integrated behavior of biomolecular-cellular networks is central to systems biology. Over several decades, systems biology has been shaped by quantitative biologists, physicists, mathematicians, and engineers in different ways. However, the basic and applied versions of systems biology are not typically distinguished, which blurs the separate aspirations of the field and its potential for real-world impact. Here, we articulate an engineering approach to systems biology, which applies educational philosophy, engineering design, and predictive models to solve contemporary problems in an age of biomedical Big Data. A concerted effort to train systems bioengineers will provide a versatile workforce capable of tackling the diverse challenges faced by the biotechnological and pharmaceutical sectors in a modern, information-dense economy.

  4. In silico approaches to RNA aptamer design.

    Science.gov (United States)

    Hamada, Michiaki

    2018-02-01

    RNA aptamers are ribonucleic acids that bind to specific target molecules. An RNA aptamer for a disease-related protein has great potential for development into a new drug. However, huge time and cost investments are required to develop an RNA aptamer into a pharmaceutical. Recently, SELEX combined with high-throughput sequencers (i.e., HT-SELEX) has been widely used to select candidate RNA aptamers that bind to a target protein with high affinity and specificity. After candidate selection, further optimizations such as shortening and modifying candidate sequences are performed. In these steps, in silico approaches are expected to reduce the time and cost associated with aptamer drug development. In this article, we review existing in silico approaches to RNA aptamer development, including a method for ranking the candidates of RNA aptamers from HT-SELEX data, clustering a huge number of aptamer sequences, and finding motifs amidst a set of significant RNA aptamers. It is expected that further studies in addition to these methods will be utilized for in silico RNA aptamer design, permitting a minimal number of experiments to be performed through the utilization of sophisticated computational methods. Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

  5. Distributed design approach in persistent identifiers systems

    Science.gov (United States)

    Golodoniuc, Pavel; Car, Nicholas; Klump, Jens

    2017-04-01

    , we propose using Distributed Hash Tables (DHT), Peer Exchange networks (PEX), Magnet Links, and peer-to-peer (P2P) file sharing networks - the technologies that enable applications such as BitTorrent (Wu et al., 2010). The proposed approach introduces reliable information replication and caching mechanisms, eliminating the need for a central PID data store, and increases overall system fault tolerance due to the lack of a single point of failure. The proposed PID system's design aims to ensure trustworthiness of the system and incorporates important aspects of governance, such as the notion of the authoritative source, data integrity, caching, and data replication control.

  6. Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.

    Science.gov (United States)

    Foster, Toshana L; Thompson, Gary S; Kalverda, Arnout P; Kankanala, Jayakanth; Bentham, Matthew; Wetherill, Laura F; Thompson, Joseph; Barker, Amy M; Clarke, Dean; Noerenberg, Marko; Pearson, Arwen R; Rowlands, David J; Homans, Steven W; Harris, Mark; Foster, Richard; Griffin, Stephen

    2014-02-01

    Current interferon-based therapy for hepatitis C virus (HCV) infection is inadequate, prompting a shift toward combinations of direct-acting antivirals (DAA) with the first protease-targeted drugs licensed in 2012. Many compounds are in the pipeline yet primarily target only three viral proteins, namely, NS3/4A protease, NS5B polymerase, and NS5A. With concerns growing over resistance, broadening the repertoire for DAA targets is a major priority. Here we describe the complete structure of the HCV p7 protein as a monomeric hairpin, solved using a novel combination of chemical shift and nuclear Overhauser effect (NOE)-based methods. This represents atomic resolution information for a full-length virus-coded ion channel, or "viroporin," whose essential functions represent a clinically proven class of antiviral target exploited previously for influenza A virus therapy. Specific drug-protein interactions validate an allosteric site on the channel periphery and its relevance is demonstrated by the selection of novel, structurally diverse inhibitory small molecules with nanomolar potency in culture. Hit compounds represent a 10,000-fold improvement over prototypes, suppress rimantadine resistance polymorphisms at submicromolar concentrations, and show activity against other HCV genotypes. This proof-of-principle that structure-guided design can lead to drug-like molecules affirms p7 as a much-needed new target in the burgeoning era of HCV DAA. Copyright © 2013 The Authors. HEPATOLOGY published by Wiley on behalf of the American Association for the Study of Liver Diseases.

  7. A compositional approach to modelling design rationale

    NARCIS (Netherlands)

    Brazier, F.M.; van Langen, P.H.G.; Treur, J.

    1997-01-01

    Design support systems need to be developed on the basis of an understanding of the human design process, in order to be useful during design. The explicit representation of design history and rationale are of particular importance for explanation and re-use. Within the DESIRE framework for

  8. Designing future learning. A posthumanist approach to researching design processes

    DEFF Research Database (Denmark)

    Juelskjær, Malou

    I investigate how a design process – leading up to the design of a new education building - enact, transform and highlight tacit everyday practices and experiences in an education setting, whereby becoming an art of managing. I apply a post-humanist performative perspective, highlighting entangled...... agencies rather than focusing on human agency. I focus on the design process rather than the designer. The design process accelerated and performed past and future experiences of schooling, learning, teaching. This called for analytical attention to agential forces of not only the material but also...... and temporalities matter in design processes. Furthermore, the analysis emphasise how design translate affective economies and that attention to those affective economies are vital for the result of the design process....

  9. Viable approach to manage superficial enamel discoloration

    Science.gov (United States)

    Chhabra, Naveen; Singbal, Kiran P.

    2010-01-01

    Esthetics is a primary concern amongst young patients and represents a challenge to the dentist. Discolored teeth are frequently seen in the general population. Several techniques have been devised to minimize or completely eliminate tooth discoloration. This case report highlights the successful management of enamel discoloration via modified microabrasion technique followed by in office bleaching. PMID:22114441

  10. Viable approach to manage superficial enamel discoloration

    Directory of Open Access Journals (Sweden)

    Naveen Chhabra

    2010-01-01

    Full Text Available Esthetics is a primary concern amongst young patients and represents a challenge to the dentist. Discolored teeth are frequently seen in the general population. Several techniques have been devised to minimize or completely eliminate tooth discoloration. This case report highlights the successful management of enamel discoloration via modified microabrasion technique followed by in office bleaching.

  11. Designing Viable Business Models for Living Labs

    Directory of Open Access Journals (Sweden)

    Bernhard R. Katzy

    2012-09-01

    Full Text Available Over 300 regions have integrated the concept of living labs into their economic development strategy since 2006, when the former Finnish Prime Minister Esko Aho launched the living lab innovation policy initiative during his term of European presidency. Despite motivating initial results, however, success cases of turning research into usable new products and services remain few and uncertainty remains on what living labs actually do and contribute. This practitioner-oriented article presents a business excellence model that shows processes of idea creation and team mobilization, new product development, user involvement, and entrepreneurship through which living labs deliver high-potential investment opportunities. Customers of living labs are identified as investors such as venture capitalists or industrial firms because living labs can generate revenue from them to create their own sustainable business model. The article concludes that living labs provide extensive support “lab” infrastructure and that it remains a formidable challenge to finance it, which calls for a more intensive debate.

  12. Sun-believable solar paint. A transformative one-step approach for designing nanocrystalline solar cells.

    Science.gov (United States)

    Genovese, Matthew P; Lightcap, Ian V; Kamat, Prashant V

    2012-01-24

    A transformative approach is required to meet the demand of economically viable solar cell technology. By making use of recent advances in semiconductor nanocrystal research, we have now developed a one-coat solar paint for designing quantum dot solar cells. A binder-free paste consisting of CdS, CdSe, and TiO(2) semiconductor nanoparticles was prepared and applied to conducting glass surface and annealed at 473 K. The photoconversion behavior of these semiconductor film electrodes was evaluated in a photoelectrochemical cell consisting of graphene-Cu(2)S counter electrode and sulfide/polysulfide redox couple. Open-circuit voltage as high as 600 mV and short circuit current of 3.1 mA/cm(2) were obtained with CdS/TiO(2)-CdSe/TiO(2) electrodes. A power conversion efficiency exceeding 1% has been obtained for solar cells constructed using the simple conventional paint brush approach under ambient conditions. Whereas further improvements are necessary to develop strategies for large area, all solid state devices, this initial effort to prepare solar paint offers the advantages of simple design and economically viable next generation solar cells. © 2011 American Chemical Society

  13. Bionic Design Methods - A practical approach

    DEFF Research Database (Denmark)

    Kepler, Jørgen Asbøll; Stokholm, Marianne Denise J.

    2004-01-01

    Nature has served as inspiration for product design throughout history. Applications range from poetic translations of form to utilization of primary functional principles. This paper describes a generally applicable design methodology for transforming natural functional principles to feasible pr...

  14. Multiobjective engineering design optimization problems: a sensitivity analysis approach

    Directory of Open Access Journals (Sweden)

    Oscar Brito Augusto

    2012-12-01

    Full Text Available This paper proposes two new approaches for the sensitivity analysis of multiobjective design optimization problems whose performance functions are highly susceptible to small variations in the design variables and/or design environment parameters. In both methods, the less sensitive design alternatives are preferred over others during the multiobjective optimization process. While taking the first approach, the designer chooses the design variable and/or parameter that causes uncertainties. The designer then associates a robustness index with each design alternative and adds each index as an objective function in the optimization problem. For the second approach, the designer must know, a priori, the interval of variation in the design variables or in the design environment parameters, because the designer will be accepting the interval of variation in the objective functions. The second method does not require any law of probability distribution of uncontrollable variations. Finally, the authors give two illustrative examples to highlight the contributions of the paper.

  15. Design Buildings Optimally: A Lifecycle Assessment Approach

    KAUST Repository

    Hosny, Ossama

    2013-01-01

    This paper structures a generic framework to support optimum design for multi-buildings in desert environment. The framework is targeting an environmental friendly design with minimum lifecycle cost, using Genetic Algorithms (Gas). GAs function through a set of success measures which evaluates the design, formulates a proper objective, and reflects possible tangible/intangible constraints. The framework optimizes the design and categorizes it under a certain environmental category at minimum Life Cycle Cost (LCC). It consists of three main modules: (1) a custom Building InformationModel (BIM) for desert buildings with a compatibility checker as a central interactive database; (2) a system evaluator module to evaluate the proposed success measures for the design; and (3) a GAs optimization module to ensure optimum design. The framework functions through three levels: the building components, integrated building, and multi-building levels. At the component level the design team should be able to select components in a designed sequence to ensure compatibility among various components, while at the building level; the team can relatively locate and orient each individual building. Finally, at the multi-building (compound) level the whole design can be evaluated using success measures of natural light, site capacity, shading impact on natural lighting, thermal change, visual access and energy saving. The framework through genetic algorithms optimizes the design by determining proper types of building components and relative buildings locations and orientations which ensure categorizing the design under a specific category or meet certain preferences at minimum lifecycle cost.

  16. Digital design (Verilog) an embedded systems approach using Verilog

    CERN Document Server

    Ashenden, Peter J

    2007-01-01

    Digital Design: An Embedded Systems Approach Using Verilog provides a foundation in digital design for students in computer engineering, electrical engineering and computer science courses. It takes an up-to-date and modern approach of presenting digital logic design as an activity in a larger systems design context. Rather than focus on aspects of digital design that have little relevance in a realistic design context, this book concentrates on modern and evolving knowledge and design skills. Hardware description language (HDL)-based design and verification is emphasized--Veril

  17. Digital design (VHDL) an embedded systems approach using VHDL

    CERN Document Server

    Ashenden, Peter J

    2007-01-01

    Digital Design: An Embedded Systems Approach Using VHDL provides a foundation in digital design for students in computer engineering, electrical engineering and computer science courses. It takes an up-to-date and modern approach of presenting digital logic design as an activity in a larger systems design context. Rather than focus on aspects of digital design that have little relevance in a realistic design context, this book concentrates on modern and evolving knowledge and design skills. Hardware description language (HDL)-based design and verification is emphasized--VHDL exa

  18. Innovation and design approaches within prospective ergonomics.

    Science.gov (United States)

    Liem, André; Brangier, Eric

    2012-01-01

    In this conceptual article the topic of "Prospective Ergonomics" will be discussed within the context of innovation, design thinking and design processes & methods. Design thinking is essentially a human-centred innovation process that emphasises observation, collaboration, interpretation, visualisation of ideas, rapid concept prototyping and concurrent business analysis, which ultimately influences innovation and business strategy. The objective of this project is to develop a roadmap for innovation, involving consumers, designers and business people in an integrative process, which can be applied to product, service and business design. A theoretical structure comprising of Innovation perspectives (1), Worldviews supported by rationalist-historicist and empirical-idealistic dimensions (2) and Models of "design" reasoning (3) precedes the development and classification of existing methods as well as the introduction of new ones.

  19. Unifying Approach to Software and Hardware Design for Scientific Calculations

    OpenAIRE

    Litvinov, G. L.; Maslov, V. P.; Rodionov, A. Ya.

    1999-01-01

    A unifying approach to software and hardware design generated by ideas of Idempotent Mathematics is discussed. The so-called idempotent correspondence principle for algorithms, programs and hardware units is described. A software project based on this approach is presented. Key words: universal algorithms, idempotent calculus, software design, hardware design, object oriented programming

  20. Forward-Oriented Design for Learning: Illustrating the Approach

    Science.gov (United States)

    Dimitriadis, Yannis; Goodyear, Peter

    2013-01-01

    This paper concerns sustainable approaches to design for learning, emphasising the need for designs to be able to thrive outside of the protective niches of project-based innovation. It builds on the "in medias res" framework and more specifically on a forward-oriented approach to design for learning: one that takes a pro-active design…

  1. An Optimisation Approach for Room Acoustics Design

    DEFF Research Database (Denmark)

    Holm-Jørgensen, Kristian; Kirkegaard, Poul Henning; Andersen, Lars

    2005-01-01

    This paper discuss on a conceptual level the value of optimisation techniques in architectural acoustics room design from a practical point of view. It is chosen to optimise one objective room acoustics design criterium estimated from the sound field inside the room. The sound field is modeled...... using the boundary element method where absorption is incorporated. An example is given where the geometry of a room is defined by four design modes. The room geometry is optimised to get a uniform sound pressure....

  2. Algorithm validation and hardware design interactive approach

    OpenAIRE

    Lazarescu, Mihai Teodor; M. Sartori

    1996-01-01

    In this paper we will describe a modality to speed up the design of the VLSI digital (mainly DSP) circuits and to reduce the design errors by increasing the interaction between the ad-hoc software program developed to validate the algorithm and the VHDL description and simulation. A real case of a digital power analyzer will be used for exemplification

  3. Ergonomics approaches to sociotechnical design processes

    DEFF Research Database (Denmark)

    Broberg, Ole

    2003-01-01

    A five-year design process of a continuous process wok has been studied with the aim of elucidating the conditions for integrating work environment aspects. The design process was seen as a network building activity and as a social shaping process of the artefact. A work environment log is sugges...

  4. Digital Hardware Design Teaching: An Alternative Approach

    Science.gov (United States)

    Benkrid, Khaled; Clayton, Thomas

    2012-01-01

    This article presents the design and implementation of a complete review of undergraduate digital hardware design teaching in the School of Engineering at the University of Edinburgh. Four guiding principles have been used in this exercise: learning-outcome driven teaching, deep learning, affordability, and flexibility. This has identified…

  5. A HYBRID APPROACH FOR RURAL FEEDER DESIGN

    Directory of Open Access Journals (Sweden)

    DAMANJEET KAUR

    2012-08-01

    Full Text Available In this paper, a population based approach for conductor size selection in rural radial distribution system is presented. The proposed hybrid approach implies a particle swarm optimization (PSO approach in combination with mutant property of differential evolution (DE for conductor size selection in radial distribution system. The conductor size for each feeder segment is selected such that the total cost of capital investment and capitalized cost of energy losses is minimized while constraints of voltage at each node and current carrying capacity of conductor is within the limits. The applicability and effectiveness of the proposed method is demonstrated with the help of 32-node test system.

  6. Different design approaches to structural fire safety

    DEFF Research Database (Denmark)

    Giuliani, Luisa; Budny, I.

    2013-01-01

    ) design for resistance class; ii) design for fully developed fire; iii) advanced design.The first two refer to well established procedures proposed by prescriptive regulations, and even if it seem possible to identify different unexpressed safety goals among the two, still it is not easy to a...... with reference to one frame of the considered car park, outlining the most problematic aspects in the modelling and in the interpretation of the results and making a focus on the collapse mechanisms of steel frames such has catenary action and sway and non-sway collapse....

  7. Robust decentralized power system controller design: Integrated approach

    Science.gov (United States)

    Veselý, Vojtech

    2017-09-01

    A unique approach to the design of gain scheduled controller (GSC) is presented. The proposed design procedure is based on the Bellman-Lyapunov equation, guaranteed cost and robust stability conditions using the parameter dependent quadratic stability approach. The obtained feasible design procedures for robust GSC design are in the form of BMI with guaranteed convex stability conditions. The obtained design results and their properties are illustrated in the simultaneously design of controllers for simple model (6-order) turbogenerator. The results of the obtained design procedure are a PI automatic voltage regulator (AVR) for synchronous generator, a PI governor controller and a power system stabilizer for excitation system.

  8. Integrated Approach to Industrial Packaging Design

    Science.gov (United States)

    Vorobeva, O.

    2017-11-01

    The article reviews studies in the field of industrial packaging design. The major factors which influence technological, ergonomic, economic and ecological features of packaging are established. The main modern trends in packaging design are defined, the principles of marketing communications and their influence on consumers’ consciousness are indicated, and the function of packaging as a transmitter of brand values is specified. Peculiarities of packaging technology and printing techniques in modern printing industry are considered. The role of designers in the stage-by-stage development of the construction, form and graphic design concept of packaging is defined. The examples of authentic packaging are given and the mention of the tetrahedron packaging history is made. At the end of the article, conclusions on the key research aspects are made.

  9. Investigating design: A comparison of manifest and latent approaches

    DEFF Research Database (Denmark)

    Cash, Philip; Snider, Chris

    2014-01-01

    them together and explicitly investigating their complementarity in the design domain. This is realised using an example artificial observation study. In addition to discussing underlying relationships between the approaches, this paper identifies key opportunities for improving design research methods......This paper contributes to the on-going focus on improving design research methods, by exploring and synthesising two key interrelated research approaches e manifest and latent. These approaches are widely used individually in design research, however, this paper represents the first work bringing...... by more explicitly combining both manifest and latent elements. Finally, a number of combinatory approaches are proposed based on a conceptual framework. © 2014 Elsevier Ltd. All rights reserved....

  10. Ergonomic approach for pillow concept design.

    Science.gov (United States)

    Cai, Dengchuan; Chen, Hsiao-Lin

    2016-01-01

    Sleep quality is an essential factor to human beings for health. The current paper conducted four studies to provide a suitable pillow for promoting sleep quality. Study 1 investigated the natural positions of 40 subjects during sleep to derive key-points for a pillow design. The results suggested that the supine and lateral positions were alternatively 24 times a night, and the current pillows were too high for the supine position and too low for lateral positions. Study 2 measured body dimensions related to pillow design of 40 subjects to determine pillow sizes. The results suggested that the pillow height were quite different in supine position and lateral position and needed to take into consideration for a pillow design. Study 3 created a pillow design based on the results of above studies. The pillow was a U-form in the front of view in which the pillow height in the middle area was lower for the supine position, and both sides were higher for the lateral positions. Study 4 assessed sleep quality of 6 subjects by using the proposed pillows and the current pillows. The results showed that the newly designed pillow led to significantly higher sleep quality, and the new design received an innovation patent. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  11. Parametric Approach in Designing Large-Scale Urban Architectural Objects

    OpenAIRE

    Arne Riekstiņš

    2011-01-01

    When all the disciplines of various science fields converge and develop, new approaches to contemporary architecture arise. The author looks towards approaching digital architecture from parametric viewpoint, revealing its generative capacity, originating from the fields of aeronautical, naval, automobile and product-design industries. The author also goes explicitly through his design cycle workflow for testing the latest methodologies in architectural design. The design process steps involv...

  12. Power magnetic devices a multi-objective design approach

    CERN Document Server

    Sudhoff, Scott D

    2014-01-01

    Presents a multi-objective design approach to the many power magnetic devices in use today Power Magnetic Devices: A Multi-Objective Design Approach addresses the design of power magnetic devices-including inductors, transformers, electromagnets, and rotating electric machinery-using a structured design approach based on formal single- and multi-objective optimization. The book opens with a discussion of evolutionary-computing-based optimization. Magnetic analysis techniques useful to the design of all the devices considered in the book are then set forth. This material is then used for ind

  13. Linear Design Approach to a Fuzzy Controller

    DEFF Research Database (Denmark)

    Jantzen, Jan

    1999-01-01

    A ball-balancer, basically an inverted pendulum problem, is stabilised by a linear controller. With certain design choices, a fuzzy controller is equivalent to a summation; thus it can replace the linear controller. It can be claimed, that the fuzzy controller performs at least as well as the lin......A ball-balancer, basically an inverted pendulum problem, is stabilised by a linear controller. With certain design choices, a fuzzy controller is equivalent to a summation; thus it can replace the linear controller. It can be claimed, that the fuzzy controller performs at least as well...

  14. Service registry design: an information service approach

    NARCIS (Netherlands)

    Ferreira Pires, Luis; Wang, J.; van Oostrum, Arjen; Wijnhoven, Alphonsus B.J.M.

    2010-01-01

    A service registry is a Service-Oriented Architecture (SOA) component that keeps a ‘catalogue’ of available services. It stores service specifications so that these specifications can be found by potential users. Discussions on the design of service registries currently focus on technical issues,

  15. Holistic Approach to Methodology Course Design

    OpenAIRE

    Kuter, Sıtkıye

    2004-01-01

    This research study suggests an instructional model formulated for ELT 313 (Methodology in ELT I) and ELT 314 (Methodology in ELT II) courses offered by the ELT Department. The researcher scrutinizes the philosophical principles behind the design of the related courses and illustrates the instructional model developed for the students' personal, professional and social growth in the teaching field.

  16. An Australian Approach to School Design

    Science.gov (United States)

    Robinson, Leigh; Robinson, Taylor

    2009-01-01

    Contemporary education design strongly emphasises stimulating, adaptable learning environments, with spaces able to support various styles of teaching and learning. Delivering successful school buildings requires a close collaborative relationship between the architect and all key stakeholders from initial briefing through to project handover. The…

  17. Food product design. An integrated approach

    NARCIS (Netherlands)

    Linnemann, A.R.; Boekel, van M.A.J.S.

    2007-01-01

    This book explains how to apply barrier technology in food production to improve product stability and the possibilities of modelling and statistics in food product design are elaborated. Attention is given to Life Cycle Assessment as a method to determine the environmental impact of a food from

  18. A Physical Approach to Tangible Interaction Design

    DEFF Research Database (Denmark)

    Jensen, Mads Vedel

    2007-01-01

    The field of tangible interaction is growing in rich and diverse directions calling for new forms of understanding. In this paper I will present a view on tangible interaction that has a strong focus on movement and interaction qualities. I will describe a design exercise that transfers interaction...... through which the exercise was conducted and discuss the outcomes; specially the role of movement metaphors....

  19. Enumeration of viable and non-viable larvated Ascaris eggs with quantitative PCR.

    Science.gov (United States)

    Raynal, Maria; Villegas, Eric N; Nelson, Kara L

    2012-12-01

    The goal of this study was to further develop an incubation-quantitative polymerase chain reaction (qPCR) method for quantifying viable Ascaris eggs by characterizing the detection limit and number of template copies per egg, determining the specificity of the method, and testing the method with viable and inactivated larvated eggs. The number of template copies per cell was determined by amplifying DNA from known numbers of eggs at different development stages; the value was estimated to be 32 copies. The specificity of the method was tested against a panel of bacteria, fungi, protozoa and helminths, and no amplification was found with non-target DNA. Finally, fully larvated eggs were inactivated by four different treatments: 254 nm ultraviolet light, 2,000 ppm NH(3)-N at pH 9, moderate heat (48 °C) and high heat (70 °C). Concentrations of treated eggs were measured by direct microscopy and incubation-qPCR. The qPCR signal decreased following all four treatments, and was in general agreement with the decrease in viable eggs determined by microscopy. The incubation-qPCR method for enumerating viable Ascaris eggs is a promising approach that can produce results faster than direct microscopy, and may have benefits for applications such as assessing biosolids.

  20. CULTURAL DIVERSITY AND REFORMING SOCIAL BEHAVIOR: A Participatory Design Approach to Design Pedagogy

    Directory of Open Access Journals (Sweden)

    Abeer A. Hasanin

    2013-07-01

    Full Text Available This paper presents a participatory design approach as an alternative model for design education. This is to show how implementing collaborative design affects the design process in comparison to the conventional design studio teaching methods and techniques. It also presents a literature review focused on the importance of integrating cultural diversity and social context within the design studio environment implementing the co-design A review of traditional design studio teaching, cultural diversity, and social behavior issues, their effect on design decisions, and their implications on design outcomes is undertaken. The paper investigates two questions: 1. Does current design education achieve the skills, learning, and training necessary for the students to become successful professionals in design practice? 2. How can integrating the participatory design approach within the design studio affect the design output and understanding cultural differences?

  1. Mask design automation: an integrated approach

    Science.gov (United States)

    Gladhill, Richard; Buck, Peter; Wong, Al

    2012-11-01

    Mask Design, or the process of assembling, arranging and configuring the pattern data required to make a photomask, has many characteristics that make it appropriate for automation, including a high order of complexity, many steps in the process flow, many parameters to define, and multiple flow variants. Traditionally Mask Design has been performed in several discrete steps, each having its own set of tools, processes, data formats, and parameter sets. These include, for example, Boolean layer extraction, fill pattern generation, biasing, Optical Process Compensation (OPC), frame generation (assembling the patterns relevant to reticle and wafer alignment, automated bar code identification, masking/taping borders, process control monitors and test patterns); fracture (transforming design data formats into mask write tool formats); jobdeck generation (creating the mask write tool instruction set); and Mask Rule Checking (MRC). These separate, and often non-compatible, process flows make integration challenging. Additionally, the frame generation process typically has evolved in complexity ad hoc and is often not performed in a systematic manner that makes it easily adaptable to automation.

  2. Service design as an approach for recognizing blue ocean

    OpenAIRE

    Koskelo, Minna

    2013-01-01

    This thesis aims to show that service design as an approach can be utilized for discovering new market space, referred as blue ocean and new business opportunities, and thus to show that service design can be seen as an approach for bringing the new logic for value creation into strategic level. From the field of strategic management the theory of blue ocean strategy was chosen for presenting the strategic outcome and further since there are similarities be-tween blue ocean strategy approach ...

  3. Approaches to Integrated Building Design Environments

    DEFF Research Database (Denmark)

    Bagger-Petersen, Susanne C; Andersen, Tom

    1996-01-01

    This report discusses functional requirements and specification which needs to be defined and fulfilled to initiate development of an integrated building design environment. The purpose is to outline specifications for further discussion and development. The report documents the first phase...... in an ongoing project at the Technical University of Denmark. The overall project objective is to provide a theoretically well-founded prototype of an integrated IT-system which can serve as a device of feedback from practice and as a test-bed for the developed concept and architecture....

  4. Design of Integrated Circuits Approaching Terahertz Frequencies

    DEFF Research Database (Denmark)

    Yan, Lei

    In this thesis, monolithic microwave integrated circuits(MMICs) are presented for millimeter-wave and submillimeter-wave or terahertz(THz) applications. Millimeter-wave power generation from solid state devices is not only crucial for the emerging high data rate wireless communications but also...... are designed based on the monolithic membrane supported Schottky diodes, which is under development at Chalmers University of Technology, Sweden. To simplify the baseband circuitry, the received IF signal from the subharmonic mixer is further amplified and downconverted to the DC range with a low noise...

  5. Solving homeland security's wicked problems: a design thinking approach

    OpenAIRE

    Wyckoff, Kristin L.

    2015-01-01

    Approved for public release; distribution is unlimited The Department of Homeland Security’s Science and Technology Directorate (DHS S&T) requires a consistent yet flexible approach to address wicked problems. A design-thinking methodology holds promise, as its tenets align with the diversity and complexity inherent within the homeland security environment. Design thinking emphasizes a human-centered and multidisciplinary approach to solution development. The research examined how design t...

  6. An Approach to Design of Power-Mechatronic Systems

    DEFF Research Database (Denmark)

    Andersen, T. O.; Hansen, M. R.; Conrad, Finn

    2003-01-01

    integration they just become a marginally useful, error-prone, expensive conglomeration. Synergism and integration in design set a Mechatronic System apart from a traditional, multidiciplinary system. So there is a need for new design methods and educational needs to make mechanical engineers become...... successful mechatronic engineers. The paper presents and discusses new mechtonic design approach and design methods anr IT-Tools used to demonstrate such approach and IT-Tool for modelling, simulation and control useful in analysis, synthesis, design and application of mechatronic systems with fluid power...

  7. Correct-by-construction approaches for SoC design

    CERN Document Server

    Sinha, Roopak; Basu, Samik

    2013-01-01

    This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components.

  8. Designing Domain-Specific HUMS Architectures: An Automated Approach

    Science.gov (United States)

    Mukkamala, Ravi; Agarwal, Neha; Kumar, Pramod; Sundaram, Parthiban

    2004-01-01

    The HUMS automation system automates the design of HUMS architectures. The automated design process involves selection of solutions from a large space of designs as well as pure synthesis of designs. Hence the whole objective is to efficiently search for or synthesize designs or parts of designs in the database and to integrate them to form the entire system design. The automation system adopts two approaches in order to produce the designs: (a) Bottom-up approach and (b) Top down approach. Both the approaches are endowed with a Suite of quantitative and quantitative techniques that enable a) the selection of matching component instances, b) the determination of design parameters, c) the evaluation of candidate designs at component-level and at system-level, d) the performance of cost-benefit analyses, e) the performance of trade-off analyses, etc. In short, the automation system attempts to capitalize on the knowledge developed from years of experience in engineering, system design and operation of the HUMS systems in order to economically produce the most optimal and domain-specific designs.

  9. Designing Emotionally Sound Instruction: The FEASP-Approach.

    Science.gov (United States)

    Astleitner, Hermann

    2000-01-01

    Presents strategies for making instruction more emotionally sound based on the FEASP (fear, envy, anger, sympathy, pleasure) approach. Highlights include the roles of emotions in cognitive instructional design, in motivational design of instruction, in affective education, and in emotional education; and a framework for Emotional Design of…

  10. Controller design approach based on linear programming.

    Science.gov (United States)

    Tanaka, Ryo; Shibasaki, Hiroki; Ogawa, Hiromitsu; Murakami, Takahiro; Ishida, Yoshihisa

    2013-11-01

    This study explains and demonstrates the design method for a control system with a load disturbance observer. Observer gains are determined by linear programming (LP) in terms of the Routh-Hurwitz stability criterion and the final-value theorem. In addition, the control model has a feedback structure, and feedback gains are determined to be the linear quadratic regulator. The simulation results confirmed that compared with the conventional method, the output estimated by our proposed method converges to a reference input faster when a load disturbance is added to a control system. In addition, we also confirmed the effectiveness of the proposed method by performing an experiment with a DC motor. © 2013 ISA. Published by ISA. All rights reserved.

  11. Sustainable Design Approach: A case study of BIM use

    Science.gov (United States)

    Abdelhameed, Wael

    2017-11-01

    Achieving sustainable design in areas such as energy-efficient design depends largely on the accuracy of the analysis performed after the design is completed with all its components and material details. There are different analysis approaches and methods that predict relevant values and metrics such as U value, energy use and energy savings. Although certain differences in the accuracy of these approaches and methods have been recorded, this research paper does not focus on such matter, where determining the reason for discrepancies between those approaches and methods is difficult, because all error sources act simultaneously. The research paper rather introduces an approach through which BIM, building information modelling, can be utilised during the initial phases of the designing process, by analysing the values and metrics of sustainable design before going into the design details of a building. Managing all of the project drawings in a single file, BIM -building information modelling- is well known as one digital platform that offers a multidisciplinary detailed design -AEC model (Barison and Santos, 2010, Welle et.al., 2011). The paper presents in general BIM use in the early phases of the design process, in order to achieve certain required areas of sustainable design. The paper proceeds to introduce BIM use in specific areas such as site selection, wind velocity and building orientation, in terms of reaching the farther possible sustainable solution. In the initial phases of designing, material details and building components are not fully specified or selected yet. The designer usually focuses on zoning, topology, circulations, and other design requirements. The proposed approach employs the strategies and analysis of BIM use during those initial design phases in order to have the analysis and results of each solution or alternative design. The stakeholders and designers would have a better effective decision making process with a full clarity of each

  12. Nodal failure index approach to groundwater remediation design

    Science.gov (United States)

    Lee, J.; Reeves, H.W.; Dowding, C.H.

    2008-01-01

    Computer simulations often are used to design and to optimize groundwater remediation systems. We present a new computationally efficient approach that calculates the reliability of remedial design at every location in a model domain with a single simulation. The estimated reliability and other model information are used to select a best remedial option for given site conditions, conceptual model, and available data. To evaluate design performance, we introduce the nodal failure index (NFI) to determine the number of nodal locations at which the probability of success is below the design requirement. The strength of the NFI approach is that selected areas of interest can be specified for analysis and the best remedial design determined for this target region. An example application of the NFI approach using a hypothetical model shows how the spatial distribution of reliability can be used for a decision support system in groundwater remediation design. ?? 2008 ASCE.

  13. Top Down Approach: SIMULINK Mixed Hardware / Software Design

    OpenAIRE

    Atat, Youssef; Rizk, Mostafa

    2012-01-01

    System-level design methodologies have been introduced as a solution to handle the design complexity of mixed Hardware / Software systems. In this paper we describe a system-level design flow starting from Simulink specification, focusing on concurrent hardware and software design and verification at four different abstraction levels: System Simulink model, Transaction Simulink model, Macro architecture, and micro architecture. We used the MP3 CodeC application, to validate our approach and m...

  14. Mechatronic System Design Based On An Optimisation Approach

    DEFF Research Database (Denmark)

    Andersen, Torben Ole; Pedersen, Henrik Clemmensen; Hansen, Michael Rygaard

    The envisaged objective of this paper project is to extend the current state of the art regarding the design of complex mechatronic systems utilizing an optimisation approach. We propose to investigate a novel framework for mechatronic system design. The novelty and originality being the use...... of optimisation techniques. The methods used to optimise/design within the classical disciplines will be identified and extended to mechatronic system design....

  15. Total-System Approach To Design And Analysis Of Structures

    Science.gov (United States)

    Verderaime, V.

    1995-01-01

    Paper presents overview and study of, and comprehensive approach to, multidisciplinary engineering design and analysis of structures. Emphasizes issues related to design of semistatic structures in environments in which spacecraft launched, underlying concepts applicable to other structures within unique terrestrial, marine, or flight environments. Purpose of study to understand interactions among traditionally separate engineering design disciplines with view toward optimizing not only structure but also overall design process.

  16. Application of an instructional systems design approach by teachers in higher education: individual versus team design

    NARCIS (Netherlands)

    Hoogveld, Bert; Paas, Fred; Jochems, Wim

    2010-01-01

    Hoogveld, A. W. M., Paas, F., & Jochems, W. M. G. (2003). Application of an instructional systems design approach by teachers in higher education: individual versus team design. Teaching and Teacher Education, 19, 581-590.

  17. Cork Design : A Design Action Intervention Approach Towards Sustainable Product Innovation

    NARCIS (Netherlands)

    Mestre, A.C.C.M.

    2014-01-01

    The study Cork Design: A Design Action Intervention Approach Towards Sustainable Product Innovation comprises the systematic implementation of sustainable product innovation within the Portuguese cork sector, through action research. Cork is a natural, recyclable, non-toxic, and renewable resource,

  18. Franz Kafka in the Design Studio: A Hermeneutic-Phenomenological Approach to Architectural Design Education

    Science.gov (United States)

    Hisarligil, Beyhan Bolak

    2012-01-01

    This article demonstrates the outcomes of taking a hermeneutic phenomenological approach to architectural design and discusses the potentials for imaginative reasoning in design education. This study tests the use of literature as a verbal form of art and design and the contribution it can make to imaginative design processes--which are all too…

  19. From a Disciplinary to an Interdisciplinary Design Research: Developing an Integrative Approach for Design

    Science.gov (United States)

    Chou, Wen Huei; Wong, Ju-Joan

    2015-01-01

    As the new generation of designers face more complex design issues, the forms of design research start to shift towards a user-centred approach to problem-solving. The cooperation and communication among various fields and specialisations are becoming more complex; in many practical design cases, in particular, technology developers face…

  20. A Bayesian experimental design approach to structural health monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Farrar, Charles [Los Alamos National Laboratory; Flynn, Eric [UCSD; Todd, Michael [UCSD

    2010-01-01

    Optimal system design for SHM involves two primarily challenges. The first is the derivation of a proper performance function for a given system design. The second is the development of an efficient optimization algorithm for choosing a design that maximizes, or nearly maximizes the performance function. In this paper we will outline how an SHM practitioner can construct the proper performance function by casting the entire design problem into a framework of Bayesian experimental design. The approach demonstrates how the design problem necessarily ties together all steps of the SHM process.

  1. Enzymatic isolation of viable human odontoblasts.

    Science.gov (United States)

    Cuffaro, H M; Pääkkönen, V; Tjäderhane, L

    2016-05-01

    To improve an enzymatic method previously used for isolation of rat odontoblasts to isolate viable mature human odontoblasts. Collagenase I, collagenase I/hyaluronidase mixture and hyaluronidase were used to extract mature human odontoblasts from the pulp chamber. Detachment of odontoblasts from dentine was determined with field emission scanning electron microscopy (FESEM) and to analyse the significance of differences in tubular diameter, and the t-test was used. MTT-reaction was used to analyse cell viability, and nonparametric Kruskal-Wallis and Mann-Whitney post hoc tests were used to analyse the data. Immunofluorescent staining of dentine sialoprotein (DSP), aquaporin-4 (AQP4) and matrix metalloproteinase-20 (MMP-20) and quantitative PCR (qPCR) of dentine sialophosphoprotein (DSPP) were used to confirm the odontoblastic nature of the cells. MTT-reaction and FESEM demonstrated collagenase I/hyaluronidase resulted in more effective detachment and higher viability than collagenase I alone. Hyaluronidase alone was not able to detach odontoblasts. Immunofluorescence revealed the typical odontoblastic-morphology with one process, and DSP, AQP4 and MMP-20 were detected. Quantitative PCR of DSPP confirmed that the isolated cells expressed this odontoblast-specific gene. The isolation of viable human odontoblasts was successful. The cells demonstrated morphology typical for odontoblasts and expressed characteristic odontoblast-type genes and proteins. This method will enable new approaches, such as apoptosis analysis, for studies using fully differentiated odontoblasts. © 2015 International Endodontic Journal. Published by John Wiley & Sons Ltd.

  2. Field demonstration of new bridge approach slab designs and performance.

    Science.gov (United States)

    2014-06-01

    The Louisiana Department of Transportation and Development (DOTD) has initiated a major effort to minimize the bridge end bump problem associated : with differential settlement. As a result, a new design for the approach slab was proposed, which requ...

  3. A Design Thinking Approach to Teaching Knowledge Management

    Science.gov (United States)

    Wang, Shouhong; Wang, Hai

    2008-01-01

    Pedagogies for knowledge management courses are still undeveloped. This Teaching Tip introduces a design thinking approach to teaching knowledge management. An induction model used to guide students' real-life projects for knowledge management is presented. (Contains 1 figure.)

  4. Design of efficient and safe neural stimulators a multidisciplinary approach

    CERN Document Server

    van Dongen, Marijn

    2016-01-01

    This book discusses the design of neural stimulator systems which are used for the treatment of a wide variety of brain disorders such as Parkinson’s, depression and tinnitus. Whereas many existing books treating neural stimulation focus on one particular design aspect, such as the electrical design of the stimulator, this book uses a multidisciplinary approach: by combining the fields of neuroscience, electrophysiology and electrical engineering a thorough understanding of the complete neural stimulation chain is created (from the stimulation IC down to the neural cell). This multidisciplinary approach enables readers to gain new insights into stimulator design, while context is provided by presenting innovative design examples. Provides a single-source, multidisciplinary reference to the field of neural stimulation, bridging an important knowledge gap among the fields of bioelectricity, neuroscience, neuroengineering and microelectronics;Uses a top-down approach to understanding the neural activation proc...

  5. Forward-oriented design for learning: illustrating the approach

    Directory of Open Access Journals (Sweden)

    Yannis Dimitriadis

    2013-08-01

    Full Text Available This paper concerns sustainable approaches to design for learning, emphasising the need for designs to be able to thrive outside of the protective niches of project-based innovation. It builds on the “in medias res” framework and more specifically on a forward-oriented approach to design for learning: one that takes a pro-active design stance with respect to each of the phases of an extended lifecycle. We draw on fieldwork notes and interview data to describe two cases that illustrate some of the key features of the approach. Recommendations for further R&D in the area of design for learning are provided, derived from the theoretical framework, and illustrated in this paper.

  6. A Parametric Urban Design Approach to Urban Development in Cairo

    DEFF Research Database (Denmark)

    Steinø, Nicolai

    2017-01-01

    in the course of participatory processes, as the consequences of changing different parameters cannot easily be evaluated by means of traditional design tools. In recent years, new parametric design tools have opened up new possibilities for dynamic scenario building in urban design. By way of a parametric...... design approach, different urban design parameters can be modified and new urban space scenarios can be rendered three-dimensionally in almost real time. In short, this is parametric urban design. It opens up completely new possibilities for participatory design, as both lay stakeholders and non......-designer professionals can provide input and evaluate the spatial effects instantly in the context of participatory design processes. Cairo, Egypt, currently experiences rapid urban growth, while formal urban planning is absent in large parts, resulting in large-scale informal and unplanned development. A parametric...

  7. Viable Syntax: Rethinking Minimalist Architecture

    Directory of Open Access Journals (Sweden)

    Ken Safir

    2010-03-01

    Full Text Available Hauser et al. (2002 suggest that the human language faculty emerged as a genetic innovation in the form of what is called here a ‘keystone factor’—a single, simple, formal mental capability that, interacting with the pre-existing faculties of hominid ancestors, caused a cascade of effects resulting in the language faculty in modern humans. They take Merge to be the keystone factor, but instead it is posited here that Merge is the pre-existing mechanism of thought made viable by a principle that permits relations interpretable at the interfaces to be mapped onto c-command. The simplified minimalist architecture proposed here respects the keystone factor as closely as possible, but is justified on the basis of linguistic analyses it makes available, including a relativized intervention theory applicable across Case, scope, agreement, selection and linearization, a derivation of the A/A’-distinction from Case theory, and predictions such as why in situ wh-interpretation is island-insensitive, but susceptible to intervention effects.

  8. Rugate filter design: An analytical approach using uniform WKB solutions

    Science.gov (United States)

    Perelman, N.; Averbukh, I.

    1996-03-01

    An analytical approach to the design of rugate filters with a smooth amplitude modulation of the sine-wave index is developed. The approach is based on the uniform WKB solutions (asymptotic expansions) of the coupled-wave equations. A closed-form solution for the inverse problem (finding the refractive index profile for a given reflectance shape inside the stop band) is found.

  9. Mathematical-programming approaches to test item pool design

    NARCIS (Netherlands)

    Veldkamp, Bernard P.; van der Linden, Willem J.; Ariel, A.

    2002-01-01

    This paper presents an approach to item pool design that has the potential to improve on the quality of current item pools in educational and psychological testing andhence to increase both measurement precision and validity. The approach consists of the application of mathematical programming

  10. a new approach to concrete mix design using computer techniques

    African Journals Online (AJOL)

    Engr. Vincent okoloekwe

    The software package for this process can be accessed from the. Internet [3]. METHODOLOGY. Modeling requires substantial data for a truly representative model to be developed. The approach adopted in this. A NEW APPROACH TO CONCRETE MIX DESIGN USING COMPUTER TECHNIQUES 27. NIGERIAN JOURNAL ...

  11. Design support for motion control systems : a mechatronic approach

    NARCIS (Netherlands)

    Coelingh, H.J.

    2000-01-01

    This thesis discusses the development of a design support for motion control systems, using a mechatronic design approach. The placement module of the Philips Fast Component Mounter (FCM), an industrial pick-and-place machine, is used as a running example. To fully exploit the advantages of

  12. The Logical Framework Approach to Project Design and Management.

    Science.gov (United States)

    Sartorius, Rolf H.

    1991-01-01

    The Logical Framework (LogFrame) approach to project design and management is introduced for planners, evaluators, and project managers. Lessons learned from its international use, and applications of LogFrame and its computer software package are discussed. This flexible tool can improve project planning and design for almost any project. (SLD)

  13. Implementing Project Based Learning Approach to Graphic Design Course

    Science.gov (United States)

    Riyanti, Menul Teguh; Erwin, Tuti Nuriah; Suriani, S. H.

    2017-01-01

    The purpose of this study was to develop a learning model based Commercial Graphic Design Drafting project-based learning approach, was chosen as a strategy in the learning product development research. University students as the target audience of this model are the students of the fifth semester Visual Communications Design Studies Program…

  14. Conjecture Mapping: An Approach to Systematic Educational Design Research

    Science.gov (United States)

    Sandoval, William

    2014-01-01

    Design research is strongly associated with the learning sciences community, and in the 2 decades since its conception it has become broadly accepted. Yet within and without the learning sciences there remains confusion about how to do design research, with most scholarship on the approach describing what it is rather than how to do it. This…

  15. An Agent Based approach to design Serious Game

    Directory of Open Access Journals (Sweden)

    Manuel Gentile

    2014-06-01

    Full Text Available Serious games are designed to train and educate learners, opening up new learning approaches like exploratory learning and situated cognition.  Despite growing interest in these games, their design is still an artisan process.On the basis of experiences in designing computer simulation, this paper proposes an agent-based approach to guide the design process of a serious game. The proposed methodology allows the designer to strike the right equilibrium between educational effectiveness and entertainment, realism and complexity.The design of the PNPVillage game is used as a case study. The PNPVillage game aims to introduce and foster an entrepreneurial mindset among young students. It was implemented within the framework of the European project “I  can… I cannot… I go!” Rev.2

  16. Parametric Approach in Designing Large-Scale Urban Architectural Objects

    Directory of Open Access Journals (Sweden)

    Arne Riekstiņš

    2011-04-01

    Full Text Available When all the disciplines of various science fields converge and develop, new approaches to contemporary architecture arise. The author looks towards approaching digital architecture from parametric viewpoint, revealing its generative capacity, originating from the fields of aeronautical, naval, automobile and product-design industries. The author also goes explicitly through his design cycle workflow for testing the latest methodologies in architectural design. The design process steps involved: extrapolating valuable statistical data about the site into three-dimensional diagrams, defining certain materiality of what is being produced, ways of presenting structural skin and structure simultaneously, contacting the object with the ground, interior program definition of the building with floors and possible spaces, logic of fabrication, CNC milling of the proto-type. The author’s developed tool that is reviewed in this article features enormous performative capacity and is applicable to various architectural design scales.Article in English

  17. Healthy campus by open space design: Approaches and guidelines

    Directory of Open Access Journals (Sweden)

    Stephen Siu Yu Lau

    2014-12-01

    Full Text Available This paper examines the architectural and landscape design strategies and intentions for green, open spaces facilities targeting stress alleviation for learning environments such as those of university campuses in a compact urban setting. Literature reviews provide three prevailing perspectives for physical design pedagogical operatives: healing gardens where greenery and plants produce restorative effects; flexible spaces that accommodate functional needs of different activities; and green buildings that incorporate open space as a catalyst for integrated eco-system. Corresponding design approaches (landscape design, spatial design and green design are scrutinized by case study. A comparison of two university campuses with different urban contexts is conducted to identify challenges and opportunities for applying these design approaches. For a compact campus, high-dense surroundings may limit the size of an open space and may handicap circulation and accessibility; on the other side, a small open space may provide its users more intimate contact with natural restorative elements and also a more controllable microclimate for physical comfort. A healthy campus should encompass diverse open spaces to satisfy different purposes. Finally, a framework that integrates the three approaches is combined to produce a sustainable design rubric.

  18. LMI–based robust controller design approach in aircraft multidisciplinary design optimization problem

    Directory of Open Access Journals (Sweden)

    Qinghua Zeng

    2015-07-01

    Full Text Available This article proposes a linear matrix inequality–based robust controller design approach to implement the synchronous design of aircraft control discipline and other disciplines, in which the variation in design parameters is treated as equivalent perturbations. Considering the complicated mapping relationships between the coefficient arrays of aircraft motion model and the aircraft design parameters, the robust controller designed is directly based on the variation in these coefficient arrays so conservative that the multidisciplinary design optimization problem would be too difficult to solve, or even if there is a solution, the robustness of design result is generally poor. Therefore, this article derives the uncertainty model of disciplinary design parameters based on response surface approximation, converts the design problem of the robust controller into a problem of solving a standard linear matrix inequality, and theoretically gives a less conservative design method of the robust controller which is based on the variation in design parameters. Furthermore, the concurrent subspace approach is applied to the multidisciplinary system with this kind of robust controller in the design loop. A multidisciplinary design optimization of a tailless aircraft as example is shown that control discipline can be synchronous optimal design with other discipline, especially this method will greatly reduce the calculated amount of multidisciplinary design optimization and make multidisciplinary design optimization results more robustness of flight performance.

  19. Virtual Reality as Innovative Approach to the Interior Designing

    Science.gov (United States)

    Kaleja, Pavol; Kozlovská, Mária

    2017-06-01

    We can observe significant potential of information and communication technologies (ICT) in interior designing field, by development of software and hardware virtual reality tools. Using ICT tools offer realistic perception of proposal in its initial idea (the study). A group of real-time visualization, supported by hardware tools like Oculus Rift HTC Vive, provides free walkthrough and movement in virtual interior with the possibility of virtual designing. By improving of ICT software tools for designing in virtual reality we can achieve still more realistic virtual environment. The contribution presented proposal of an innovative approach of interior designing in virtual reality, using the latest software and hardware ICT virtual reality technologies

  20. Application of mechatronic design approach in a reconfigurable manufacturing environment

    CSIR Research Space (South Africa)

    Xing, B

    2008-12-01

    Full Text Available University developed RMTS (Reconfigurable Modular Manipulator System) [5]. They identified the The Application of Mechatronic Design Approach in a Reconfigurable Manufacturing Environment Bo Xing1, Nkgatho S. Tlale1, and Glen Bright2 1 Council of Science...VIP08),2-4 Dec 2008,Auckland,New-Zealand © 2008 ISBN: 978-0-473-13532-4 138 characteristics of reconfigurable machine design as a task based design and developed a design methodology for reconfigurable manipulators from the kinematics task...

  1. Roundabout design and elderly drivers.

    Science.gov (United States)

    2011-10-01

    Many drivers are apprehensive to accept a roundabout as a viable form of intersection, but their : safety and mobility benefits are increasing their popularity among designers. This thesis is an indepth study of a specific approach at a roundabout in...

  2. Assessment of Algal Farm Designs using a Dynamic Modular Approach

    Energy Technology Data Exchange (ETDEWEB)

    Abodeely, Jared M. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Stevens, Daniel M. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Ray, Allison E. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Newby, Deborah T. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Coleman, Andre M. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Hydrology Technical Group; Cafferty, Kara G. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology

    2014-07-01

    The notion of renewable energy provides an importantmechanism for diversifying an energy portfolio,which ultimately would have numerous benefits including increased energy resilience, reduced reliance on foreign energysupplies, reduced GHG emissions, development of a green energy sector that contributes to economic growth,and providing a sustainable energy supply. The conversion of autotrophic algae to liquid transportation fuels is the basis of several decades of research to competitively bring energy-scale production into reality; however, many challenges still remain for making algal biofuels economically viable. Addressing current challenges associatedwith algal production systems, in part, requires the ability to assess spatial and temporal variability, rapidly evaluate alternative algal production system designs, and perform large-scale assessments considering multiple scenarios for thousands of potential sites. We introduce the development and application of the Algae Logistics Model (ALM) which is tailored to help address these challenges. The flexible nature of the ALM architecture allows the model to: 1) interface with external biomass production and resource assessment models, as well as other relevant datasets including those with spatiotemporal granularity; 2) interchange design processes to enable operational and economic assessments ofmultiple design configurations, including the integration of current and new innovative technologies; and 3) conduct trade-off analysis to help understand the site-specific techno-economic trade-offs and inform technology decisions. This study uses the ALM to investigate a baseline open-pond production system determined by model harmonization efforts conducted by the U.S. Department of Energy. Six sites in the U.S. southern-tierwere sub-selected and assessed using daily site-specific algaebiomass productivity data to determine the economic viability of large-scale open-pond systems. Results show that costs can vary

  3. Assessment of Algal Farm Designs Using a Dynamic Modular Approach

    Energy Technology Data Exchange (ETDEWEB)

    Abodeely, Jared [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Coleman, Andre M. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Hydrology Technical Group; Stevens, Daniel M. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Ray, Allison E. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Cafferty, Kara G. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Newby, Deborah T. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology

    2014-07-01

    The notion of renewable energy provides an important mechanism for diversifying an energy portfolio, which ultimately would have numerous benefits including increased energy resilience, reduction of foreign energy supplies, reduced GHG emissions, development of a green energy sector that contributes to economic growth, and providing a sustainable energy supply. The conversion of autotrophic algae to liquid transportation fuels is the basis of several decades of research to competitively bring energy-scale production into reality; however, many challenges still remain for making algal biofuels economically viable. Addressing current challenges associated with algal production systems, in part, requires the ability to assess spatial and temporal variability, rapidly evaluate alternative algal production system designs, and perform large-scale assessments considering multiple scenarios for thousands of potential sites. We introduce the Algae Logistics Model (ALM) which helps to address these challenges. The flexible nature of the ALM architecture allows the model to: 1) interface with external biomass production and resource assessment models, as well as other relevant datasets including those with spatiotemporal granularity; 2) interchange design processes to enable operational and economic assessments of multiple design configurations, including the integration of current and new innovative technologies; and 3) conduct trade-off analysis to help understand the site-specific techno-economic trade-offs and inform technology decisions. This study uses the ALM to investigate a baseline open-pond production system determined by model harmonization efforts conducted by the U.S. Department of Energy. Six sites in the U.S. southern-tier were sub-selected and assessed using daily site-specific algae biomass productivity data to determine the economic viability of large-scale open-pond systems. Results show that costs can vary significantly depending on location and biomass

  4. Designing Trailing Edge Flaps of Wind Turbines using an Integrated Design Approach

    DEFF Research Database (Denmark)

    Mirzaei, Mahmood; Poulsen, Niels Kjølstad; Niemann, Hans Henrik

    In this paper designing a controller for trailing edge flaps (TEF) as well as optimizing its position on the wind turbine blade will be considered. An integrated design approach will be used to optimize both TEF placement and controller simultaneously. Youla parameterization will be used to param......In this paper designing a controller for trailing edge flaps (TEF) as well as optimizing its position on the wind turbine blade will be considered. An integrated design approach will be used to optimize both TEF placement and controller simultaneously. Youla parameterization will be used...

  5. Character-driven game design : a design approach and its foundations in character engagement

    OpenAIRE

    Lankoski, Petri

    2010-01-01

    In this study I propose a design approach for character-based games. In order to develop a design method for character-based games, I look at how games guide players and the playing experience (especially the relationship between formal features and playing experience). This design approach has been used in the design of the game Lies and Seductions. Research implies that people react to human-like entities (e.g., game characters) as if they were people, including empathizing with charac...

  6. Conceptual design of jewellery: a space-based aesthetics approach

    Directory of Open Access Journals (Sweden)

    Tzintzi Vaia

    2017-01-01

    Full Text Available Conceptual design is a field that offers various aesthetic approaches to generation of nature-based product design concepts. Essentially, Conceptual Product Design (CPD uses similarities based on the geometrical forms and functionalities. Furthermore, the CAD-based freehand sketch is a primary conceptual tool in the early stages of the design process. The proposed Conceptual Product Design concept is dealing with jewelleries that are inspired from space. Specifically, a number of galaxy features, such as galaxy shapes, wormholes and graphical representation of planet magnetic field are used as inspirations. Those space-based design ideas at a conceptual level can lead to further opportunities for research and economic success of the jewellery industry. A number of illustrative case studies are presented and new opportunities can be derived for economic success.

  7. How to Design Experiences: Macro UX versus Micro UX Approach

    OpenAIRE

    von Saucken, Constantin;Michailidou, Ioanna;Lindemann, Udo

    2014-01-01

    User Experience (UX) can be achieved by a user-related product’s purpose (Macro UX) as well as by pleasant embodiment design in detail concerning material, usability and interface (Micro UX). Existing approaches mostly represent the Macro UX approach and therefore demand influencing the whole development process, in particular the early stage of goal setting. Furthermore, they are often psychology-driven. For that reason they are hardly implemented in industrial practice. We observe that most...

  8. The Concepts of Accessibility and Equality in Design Education: The Universal Design Approach

    Directory of Open Access Journals (Sweden)

    Guliz Mugan Akıncı

    2014-06-01

    Full Text Available Universal design approach aims to design products and environments that provide equal access for everyone to the variety of activities. Universal design applications and research and discussions related to these applications can be seen in different fields very often especially in the last years. Concerning the fact that its possibility of application is very new in Turkey, on the one hand, one of the aims of this study is to introduce and explain this new approach. On the other hand, the study aims to exemplify how the new information related to the philosophy of universal design approach can be integrated to the design education and find the ways of application in the university environment where the next expert generation has been coached. Within this framework, it is aimed to introduce the content and the way of application of the course of “Universal Design” which have been taught in the curriculum of the Architecture and Interior Architecture Departments of Okan University. Within the scope of the course, the students are expected to investigate and analyze the reflections of seven principles of universal design in real-life settings for the different and varied groups of human beings. While integrating the universal design approach to the design education, the things that is wanted to be emphasized is, this new and different approach is an inspiring fact for the new generation of designers concerning the concepts of accessibility and equality. The designs, organizations, suggestions, studies and researches of the design students of the course has demonstrated that if the universal design principles has become a component of the design education, it would also be achieving as a rewarding and fostering attempt.

  9. A design approach for integrating thermoelectric devices using topology optimization

    DEFF Research Database (Denmark)

    Soprani, Stefano; Haertel, Jan Hendrik Klaas; Lazarov, Boyan Stefanov

    2016-01-01

    . The design method incorporates temperature dependent properties of the thermoelectric device and other materials. The3D topology optimization model developed in this work was used to design a thermoelectric system, complete with insulation and heat sink, that was produced and tested. Good agreement between......Efficient operation of thermoelectric devices strongly relies on the thermal integration into the energy conversion system in which they operate. Effective thermal integration reduces the temperature differences between the thermoelectric module and its thermal reservoirs, allowing the system...... to operate more efficiently. This work proposes and experimentally demonstrates a topology optimization approach as a design tool for efficient integration of thermoelectric modules into systems with specific design constraints. The approach allows thermal layout optimization of thermoelectric systems...

  10. DESIGN AND TECHNOLOGICAL APPROACH TO TEACHER PROFESSIONAL TRAINING

    Directory of Open Access Journals (Sweden)

    Elena Sagan

    2017-10-01

    Full Text Available Relevant for teaching modern science and practice is the task of finding ways to increase motivation, learning by intensifying qualitatively new teaching tools, design and implementation of technological approach to professional training of teachers, especially primary school teacher. The article summarizes the views of scientists on the use of design technology in higher pedagogical educational institution, organization design expediency of future teachers as an example of discipline "Mathematics". Design and technological approach allows for potential developmental math through a combination of formal mathematical knowledge of the emotional and aesthetic component of their production, with the formation of subjective attitude towards new knowledge. Thus, the creation of the "World Geometry" not only promotes the popularization of science, but also influences the outlook of the future teacher, his adaptability and mobility in the modern educational environment, fundamentalization his training.

  11. A Novel Approach for Designing Mobile Native Apps

    Directory of Open Access Journals (Sweden)

    Sasmita Pani

    2017-01-01

    Full Text Available Mobile devices are differed from desktop based systems in terms of particular execution environment, constrained resources, and high mobility requirement. To overcome these shortcomings, various agile based methodologies are developed for native mobile applications such as Mobile-D, Scrum etc. These agile techniques are based on various phases and these phases begin from exploring, initializing and implementing the mobile apps. But these techniques are not focusing on elaborating design model for mobile native apps. The aim of the paper is to provide a layered approach or layered model for design of mobile native apps which can be used as a framework for developing mobile native apps. Any mobile native app developer can use this sequential approach or design model for design and development of mobile native apps. This design model gives a standard or framework, based on which generic native mobile apps can be designed and developed. This paper also shows an empirical analysis among the web app design models with the proposed design model for mobile native app development.

  12. An additive manufacturing oriented design approach to mechanical assemblies

    Directory of Open Access Journals (Sweden)

    Germain Sossou

    2018-01-01

    Full Text Available Firstly introduced as a prototyping process, additive manufacturing (AM is being more and more considered as a fully-edged manufacturing process. The number of AM processes, along with the range of processed materials are expanding. AM has made manufacturable shapes that were too difficult (or even impossible to manufacture with conventional technologies. This has promoted a shift in engineering design, from conventional design for manufacturing and assembly to design for additive manufacturing (DFAM. Research efforts into the DFAM field have been mostly dedicated to part’s design, which is actually a requirement for a better industrial adoption. This has given rise to topologically optimized and/or latticed designs. However, since AM is also capable of manufacturing fully functional assemblies requiring a few or no assembly operations, there is a need for DFAM methodologies tackling product’s development more holistically, and which are, therefore, dedicated to assembly design. Considering all the manufacturing issues related to AM of assembly-free mechanisms and available post-processing capabilities, this paper proposes a top-down assembly design methodology for AM in a proactive manner. Such an approach, can be seen as the beginning of a shift from conventional design for assembly (DFA to a new paradigm. From a product’s concept and a selected AM technology, the approach first provides assistance in the definition of the product architecture so that both functionality and successful manufacturing (including post-processing are ensured. Particularly, build-orientation and downstream processes’ characteristics are taken into account early in the design process. Secondly, for the functional flow (energy, material, signal to be appropriately conveyed by the right amount of matter, the methodology provides guidance into how the components can be designed in a minimalism fashion leveraging the shape complexity afforded by AM. A mechanical

  13. Designing to target cost: one approach to design/construction integration

    DEFF Research Database (Denmark)

    Jørgensen, Bo

    2005-01-01

    One approach to a more integrated construction delivery process is the concept of ‘designing to target cost’ of which the first examples of application within a lean construction framework have recently been seen. This paper introduces the main principles of the design to target cost method...... and discusses the applicability of this approach to construction. The low degree of organizational and technical continuity from one construction project to the next limits the applicability of the design for target cost approach when compared to its origin in product development of mass manufactured artefacts....... It can be argued that design to target cost may also provide a frame for developing the supply chain towards better coordination and collaboration. Thus methods of design to target cost may serve to facilitate the development of a more integrated supply chain....

  14. Design approaches in quarrying and pit-mining reclamation

    Science.gov (United States)

    Arbogast, Belinda F.

    1999-01-01

    Reclaimed mine sites have been evaluated so that the public, industry, and land planners may recognize there are innovative designs available for consideration and use. People tend to see cropland, range, and road cuts as a necessary part of their everyday life, not as disturbed areas despite their high visibility. Mining also generates a disturbed landscape, unfortunately one that many consider waste until reclaimed by human beings. The development of mining provides an economic base and use of a natural resource to improve the quality of human life. Equally important is a sensitivity to the geologic origin and natural pattern of the land. Wisely shaping out environment requires a design plan and product that responds to a site's physiography, ecology, function, artistic form, and publication perception. An examination of selected sites for their landscape design suggested nine approaches for mining reclamation. The oldest design approach around is nature itself. Humans may sometimes do more damage going to an area in the attempt to repair it. Given enough geologic time, a small-site area, and stable adjacent ecosystems, disturbed areas recover without mankind's input. Visual screens and buffer zones conceal the facility in a camouflage approach. Typically, earth berms, fences, and plantings are used to disguise the mining facility. Restoration targets social or economic benefits by reusing the site for public amenities, most often in urban centers with large populations. A mitigation approach attempts to protect the environment and return mined areas to use with scientific input. The reuse of cement, building rubble, macadam meets only about 10% of the demand from aggregate. Recognizing the limited supply of mineral resources and encouraging recycling efforts are steps are steps in a renewable resource approach. An educative design approach effectively communicates mining information through outreach, land stewardship, and community service. Mine sites used for

  15. Multi-Criteria Approach in Multifunctional Building Design Process

    Science.gov (United States)

    Gerigk, Mateusz

    2017-10-01

    The paper presents new approach in multifunctional building design process. Publication defines problems related to the design of complex multifunctional buildings. Currently, contemporary urban areas are characterized by very intensive use of space. Today, buildings are being built bigger and contain more diverse functions to meet the needs of a large number of users in one capacity. The trends show the need for recognition of design objects in an organized structure, which must meet current design criteria. The design process in terms of the complex system is a theoretical model, which is the basis for optimization solutions for the entire life cycle of the building. From the concept phase through exploitation phase to disposal phase multipurpose spaces should guarantee aesthetics, functionality, system efficiency, system safety and environmental protection in the best possible way. The result of the analysis of the design process is presented as a theoretical model of the multifunctional structure. Recognition of multi-criteria model in the form of Cartesian product allows to create a holistic representation of the designed building in the form of a graph model. The proposed network is the theoretical base that can be used in the design process of complex engineering systems. The systematic multi-criteria approach makes possible to maintain control over the entire design process and to provide the best possible performance. With respect to current design requirements, there are no established design rules for multifunctional buildings in relation to their operating phase. Enrichment of the basic criteria with functional flexibility criterion makes it possible to extend the exploitation phase which brings advantages on many levels.

  16. Towards a user-oriented analytical approach to learning design

    Directory of Open Access Journals (Sweden)

    Jonathan P. San Diego

    2008-12-01

    Full Text Available The London Pedagogy Planner (LPP is a prototype for a collaborative online planning and design tool that supports lecturers in developing, analysing and sharing learning designs. The tool is based on a developing model of the components involved in learning design and the critical relationships between them. As a decision tool it makes the pedagogical design explicit as an output from the process, capturing it for testing, redesign, reuse and adaptation by the originator, or by others. The aim is to test the extent to which we can engage lecturers in reflecting on learning design, and make them part of the educational community that discovers how best to use technology-enhanced learning. This paper describes the development of LPP, presents pedagogical benefits of visual representations of learning designs and proposes an analytical approach to learning design based on these visual representations. The analytical approach is illustrated based on an initial evaluation with a small group of lecturers from two partner institutions.

  17. Design science research as research approach in doctoral studies

    CSIR Research Space (South Africa)

    Kotzé, P

    2015-08-01

    Full Text Available Proceedings, Puerto Rico, 13 - 15 August 2015 Design science research as research approach in doctoral studies Paula Kotzé CSIR Meraka Institute and Department of Informatics, University of Pretoria paula.kotze@meraka.org.za Alta van der Merwe...

  18. Applicability of a computational design approach for synthetic riboswitches.

    Science.gov (United States)

    Domin, Gesine; Findeiß, Sven; Wachsmuth, Manja; Will, Sebastian; Stadler, Peter F; Mörl, Mario

    2017-04-20

    Riboswitches have gained attention as tools for synthetic biology, since they enable researchers to reprogram cells to sense and respond to exogenous molecules. In vitro evolutionary approaches produced numerous RNA aptamers that bind such small ligands, but their conversion into functional riboswitches remains difficult. We previously developed a computational approach for the design of synthetic theophylline riboswitches based on secondary structure prediction. These riboswitches have been constructed to regulate ligand-dependent transcription termination in Escherichia coli. Here, we test the usability of this design strategy by applying the approach to tetracycline and streptomycin aptamers. The resulting tetracycline riboswitches exhibit robust regulatory properties in vivo. Tandem fusions of these riboswitches with theophylline riboswitches represent logic gates responding to two different input signals. In contrast, the conversion of the streptomycin aptamer into functional riboswitches appears to be difficult. Investigations of the underlying aptamer secondary structure revealed differences between in silico prediction and structure probing. We conclude that only aptamers adopting the minimal free energy (MFE) structure are suitable targets for construction of synthetic riboswitches with design approaches based on equilibrium thermodynamics of RNA structures. Further improvements in the design strategy are required to implement aptamer structures not corresponding to the calculated MFE state. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  19. Stochastic approaches for product recovery network design: a case study

    NARCIS (Netherlands)

    O.L. Listes (Ovidiu); R. Dekker (Rommert)

    2001-01-01

    textabstractIncreased uncertainty is one of the characteristics of product recovery networks. In particular the strategic design of their logistic infrastructure has to take uncertain information into account. In this paper we present stochastic programming based approaches by which a deterministic

  20. A Pro-Forma approach to Car-Carrier Design

    CSIR Research Space (South Africa)

    Benade, R

    2016-11-01

    Full Text Available In this work a pro-forma approach is developed for assessing truck and centre-axle tag-trailer or 50/50 car-carrier designs in terms of their compliance with the South African Performance-Based Standards (PBS) pilot project requirements. First...

  1. An interdisciplinary approach to design at the University of Pretoria ...

    African Journals Online (AJOL)

    This article investigates the implementation of an interdisciplinary approach to Design in Architecture, Landscape Architecture and Interior Architecture at the University of Pretoria, South Africa. Architecture, Landscape Architecture and Interior Architecture were previously offered as distinctive academic disciplines, located ...

  2. Evaluation Design for Clusters Approach to Career Education (CACO).

    Science.gov (United States)

    Ruff, Eldon E.; Dudley, Gerald O.

    A three-part evaluation plan is presented for the occupational clusters approach to career orientation project, which attempted to design and field-test a two-semester curriculum package for orienting junior high students to the world of work. Project effectiveness will be estimated at three points in its development. In the laboratory setting…

  3. A Simple Approach to Study Designs in Complex Biochemical ...

    Indian Academy of Sciences (India)

    Somdatta Sinha

    Indian Institute of Technology,. New Delhi, 31 October 2008. Indian Academy of Sciences,. 74th Annual Meeting, New Delhi. Oct. 31 – Nov. 2, 2008. SOMDATTA SINHA. Centre for Cellular and Molecular Biology (CSIR). Hyderabad. A Simple Approach to Study. Designs in Complex. Biochemical Pathways. Symposium on.

  4. A Rational Approach to Septic Tank Design | Nnaji | Nigerian ...

    African Journals Online (AJOL)

    A new approach to the design of septic tanks was developed based on a number of critical parameters, namely: residual detention time, minimum residual detention time, residual depth and minimum residual depth. This method involved rst specifying a desired desludging interval. This interval was then substituted in a ...

  5. Advance Approach to Concept and Design Studies for Space Missions

    Science.gov (United States)

    Deutsch, M.; Nichols, J.

    1999-01-01

    Recent automated and advanced techniques developed at JPL have created a streamlined and fast-track approach to initial mission conceptualization and system architecture design, answering the need for rapid turnaround of trade studies for potential proposers, as well as mission and instrument study groups.

  6. Seeking Constructive Synergy: Design Science and the Constructive Research Approach

    DEFF Research Database (Denmark)

    Piirainen, Kalle; Gonzalez, Rafael A.

    2013-01-01

    Information systems research and management science create knowledge which can be applied in organizations. Design science specifically aims at applying existing knowledge to solve interesting and relevant business problems and has been steadily gaining support in information systems research...... and partly underlying philosophical assumptions, but both have something to teach each other about how to define and execute design-oriented research in information systems and management science........ However, design science is not the only design-oriented framework. Accordingly, this raises the question of whether it is possible to compare the results obtained from different brands of design-oriented research. This paper contributes to answering this question by comparing two research approaches...

  7. Users’ Perceptions of Aesthetic Design Approach of Safavid Architecture, Iran

    Directory of Open Access Journals (Sweden)

    Bahram Shahedi

    2012-06-01

    Full Text Available In this study, the aesthetic design approach of architectural precedents of Safavid Architecture was examined based on users' perceptions, which were obtained by using perception questionnaire instrument. The research method included concurrent qualitative and quantitative analyses of data. Data analysis procedure was conducted through descriptive statistical analysis and by sorting thematic information for Initial categories, which were defined by the theoretical foundation. The researchers found that users' perceptions fell into two distinct groups. The first: structural honesty, expressions, identity, design feature, interaction as design values in the sense of aesthetic. The second: design principle, design concept, characteristic, minimalism, and style as an attribute. Such findings revealed how Safavid architectural concepts were aesthetically integrated into the diversity aspects of its architectural precedents.

  8. Data Mining Approaches for Modeling Complex Electronic Circuit Design Activities

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Yongjin [Ajou University, Suwon, South Korea; Omitaomu, Olufemi A [ORNL; Wang, Gi-Nam [Ajou University, Suwon, South Korea

    2008-01-01

    A printed circuit board (PCB) is an essential part of modern electronic circuits. It is made of a flat panel of insulating materials with patterned copper foils that act as electric pathways for various components such as ICs, diodes, capacitors, resistors, and coils. The size of PCBs has been shrinking over the years, while the number of components mounted on these boards has increased considerably. This trend makes the design and fabrication of PCBs ever more difficult. At the beginning of design cycles, it is important to estimate the time to complete the steps required accurately, based on many factors such as the required parts, approximate board size and shape, and a rough sketch of schematics. Current approach uses multiple linear regression (MLR) technique for time and cost estimations. However, the need for accurate predictive models continues to grow as the technology becomes more advanced. In this paper, we analyze a large volume of historical PCB design data, extract some important variables, and develop predictive models based on the extracted variables using a data mining approach. The data mining approach uses an adaptive support vector regression (ASVR) technique; the benchmark model used is the MLR technique currently being used in the industry. The strengths of SVR for this data include its ability to represent data in high-dimensional space through kernel functions. The computational results show that a data mining approach is a better prediction technique for this data. Our approach reduces computation time and enhances the practical applications of the SVR technique.

  9. Sustainable Design Re-Examined: Integrated Approach to Knowledge Creation for Sustainable Interior Design

    Science.gov (United States)

    Lee, Young S.

    2014-01-01

    The article focuses on a systematic approach to the instructional framework to incorporate three aspects of sustainable design. It also aims to provide an instruction model for sustainable design stressing a collective effort to advance knowledge creation as a community. It develops a framework conjoining the concept of integrated process in…

  10. Learning Design Rashomon I--Supporting the Design of One Lesson through Different Approaches

    Science.gov (United States)

    Persico, Donatella; Pozzi, Francesca; Anastopoulou, Stamatina; Conole, Grainne; Craft, Brock; Dimitriadis, Yannis; Hernandez-Leo, Davinia; Kali, Yael; Mor, Yishay; Perez-Sanagustin, Mar; Walmsley, Helen

    2013-01-01

    This paper presents and compares a variety of approaches that have been developed to guide the decision-making process in learning design. Together with the companion Learning Design Rashomon II (Prieto "et al.," 2013), devoted to existing tools to support the same process, it aims to provide a view on relevant research results in this…

  11. Integral Morphological C-K Design Approach for Multidisciplinary Building Design

    Directory of Open Access Journals (Sweden)

    Wim Zeiler

    2010-05-01

    Full Text Available This paper presents a theoretical approach to collaborative design management. The goal is to integrate design and engineering knowledge in the conceptual phase of building design. Based on an integral design process model, morphological overviews are used as a tool to implement C-K (concept-knowledge theory, to increase knowledge creation and to stimulate knowledge exchange within the building design team. The project was carried out in close cooperation with professional societies within the building design field. The set-ups of the workshops used to implement and to test the theoretical approach are presented as well as the experiences of the participants. More than 100 experienced professionals participated in the workshops and the workshops now have become part of the permanent professional training programme of one of the professional societies. DOI: 10.3763/aedm.2008.0099 Published in the Journal AEDM - Volume 5, Number 4, 2009 , pp. 193-214(22

  12. Surgical training: design of a virtual care pathway approach.

    Science.gov (United States)

    Beyer-Berjot, Laura; Patel, Vishal; Acharya, Amish; Taylor, Dave; Bonrath, Esther; Grantcharov, Teodor; Darzi, Ara; Aggarwal, Rajesh

    2014-09-01

    Both intra- and perioperative care are essential for patients' safety. Training for intraoperative technical skills on simulators and for perioperative care in virtual patients have independently demonstrated educational value, but no training combining these 2 approaches has been designed yet. The aim of this study was to design a pathway approach for training in general surgery. A common disease requiring essential skills was chosen, namely, acute appendicitis. Preoperative care training was created using virtual patients presenting with acute right iliac fossa (RIF) pain. A competency-based curriculum for laparoscopic appendectomy (LAPP) was designed on a virtual reality simulator: Novices (100 LAPP) were enrolled to perform 2 virtual LAPP for assessment of validity evidence; novices performed 8 further LAPP for analysis of a learning curve. Finally, postoperative virtual patients were reviewed after LAPP. Four preoperative patient scenarios were designed with different presentations of RIF; not all required operative management. Comments were provided through case progression to allow autonomous practice. Ten novices and 10 experienced surgeons were enrolled for intraoperative training. Time taken (median values) of novices versus experienced surgeons (285 vs 259 seconds; P = .026) and performance score (67% vs 99%; P virtual patients were created with an uneventful or complicated outcome. A virtual care pathway approach has been designed for acute appendicitis, enabling trainees to follow simulated patients from admission to discharge. Copyright © 2014 Mosby, Inc. All rights reserved.

  13. Reliability Approach for Machine Protection Design in Particle Accelerators

    CERN Document Server

    Apollonio, A; Mikulec, B; Puccio, B; Sanchez Alvarez, J L; Schmidt, R; Wagner, S

    2013-01-01

    Particle accelerators require Machine Protection Systems (MPS) to prevent beam-induced damage of equipment in case of failures. This becomes increasingly important for proton colliders with large energy stored in the beam such as LHC, for high power accelerators with a beam power of up to 10 MW, such as the European Spallation Source (ESS), and for linear colliders with high beam power and very small beam size. The reliability of Machine Protection Systems is crucial for safe machine operation; all possible sources of risk need to be taken into account in the early design stage. This paper presents a systematic approach to classify failures and to assess the associated risk, and discusses the impact of such considerations on the design of Machine Protection Systems. The application of this approach will be illustrated using the new design of the MPS for LINAC4, a linear accelerator under construction at CERN.

  14. Bimetric gravity is cosmologically viable

    Directory of Open Access Journals (Sweden)

    Yashar Akrami

    2015-09-01

    Full Text Available Bimetric theory describes gravitational interactions in the presence of an extra spin-2 field. Previous work has suggested that its cosmological solutions are generically plagued by instabilities. We show that by taking the Planck mass for the second metric, Mf, to be small, these instabilities can be pushed back to unobservably early times. In this limit, the theory approaches general relativity with an effective cosmological constant which is, remarkably, determined by the spin-2 interaction scale. This provides a late-time expansion history which is extremely close to ΛCDM, but with a technically-natural value for the cosmological constant. We find Mf should be no larger than the electroweak scale in order for cosmological perturbations to be stable by big-bang nucleosynthesis. We further show that in this limit the helicity-0 mode is no longer strongly-coupled at low energy scales.

  15. Beyond LCDM: a viable alternative?

    CERN Document Server

    Gough, Michael Paul

    2016-01-01

    We are encouraged to look beyond LCDM as there are still no satisfactory explanations for either dark energy or dark matter. A data centred phenomenological approach supports an alternative explanation in which dark energy is not a universe-wide constant energy density, but the Holographic Dark Information Energy, HDIE, naturally centred around galaxies. HDIE can explain many of the effects attributed separately to Lambda and CDM. HDIE mimics Lambda with sufficient overall total energy and an equation of state parameter, w = -1.03+-0.05 for z 1.35, HDIE was phantom, w = -1.82+-0.08, providing a clear prediction that will enable the model to be verified or falsified. HDIE is shown to fit Planck dark energy wo-wa plots at least as well as Lambda, and to be consistent with other results that suggest dark energy was phantom at earlier times. A new w parameterisation is proposed here, as the usual CPL parameterisation is found to be biased and unsuitable for distinguishing between the HDIE/baryon and LCDM models.

  16. An industrial approach to design compelling VR and AR experience

    Science.gov (United States)

    Richir, Simon; Fuchs, Philippe; Lourdeaux, Domitile; Buche, Cédric; Querrec, Ronan

    2013-03-01

    The convergence of technologies currently observed in the field of VR, AR, robotics and consumer electronic reinforces the trend of new applications appearing every day. But when transferring knowledge acquired from research to businesses, research laboratories are often at a loss because of a lack of knowledge of the design and integration processes in creating an industrial scale product. In fact, the innovation approaches that take a good idea from the laboratory to a successful industrial product are often little known to researchers. The objective of this paper is to present the results of the work of several research teams that have finalized a working method for researchers and manufacturers that allow them to design virtual or augmented reality systems and enable their users to enjoy "a compelling VR experience". That approach, called "the I2I method", present 11 phases from "Establishing technological and competitive intelligence and industrial property" to "Improvements" through the "Definition of the Behavioral Interface, Virtual Environment and Behavioral Software Assistance". As a result of the experience gained by various research teams, this design approach benefits from contributions from current VR and AR research. Our objective is to validate and continuously move such multidisciplinary design team methods forward.

  17. Innovative design approaches for large wind turbine blades : final report.

    Energy Technology Data Exchange (ETDEWEB)

    2004-05-01

    The goal of the Blade System Design Study (BSDS) was investigation and evaluation of design and manufacturing issues for wind turbine blades in the one to ten megawatt size range. A series of analysis tasks were completed in support of the design effort. We began with a parametric scaling study to assess blade structure using current technology. This was followed by an economic study of the cost to manufacture, transport and install large blades. Subsequently we identified several innovative design approaches that showed potential for overcoming fundamental physical and manufacturing constraints. The final stage of the project was used to develop several preliminary 50m blade designs. The key design impacts identified in this study are: (1) blade cross-sections, (2) alternative materials, (3) IEC design class, and (4) root attachment. The results show that thick blade cross-sections can provide a large reduction in blade weight, while maintaining high aerodynamic performance. Increasing blade thickness for inboard sections is a key method for improving structural efficiency and reducing blade weight. Carbon/glass hybrid blades were found to provide good improvements in blade weight, stiffness, and deflection when used in the main structural elements of the blade. The addition of carbon resulted in modest cost increases and provided significant benefits, particularly with respect to deflection. The change in design loads between IEC classes is quite significant. Optimized blades should be designed for each IEC design class. A significant portion of blade weight is related to the root buildup and metal hardware for typical root attachment designs. The results show that increasing the number of blade fasteners has a positive effect on total weight, because it reduces the required root laminate thickness.

  18. Architecture Design Approaches and Issues in Cross Layer Systems

    DEFF Research Database (Denmark)

    Cattoni, Andrea Fabio; Sørensen, Troels Bundgaard; Mogensen, Preben

    2012-01-01

    , users, and physical medium issues, designers are in the need for new approaches. Cross Layer becomes than a handy solution for coping with such problems. In fact, it allows both tighter optimizations of the existing functionalities, and the introduction of new ones, that do not fit within......Wireless communications are a fast grown part of the telecommunication market. While new types of traffic and challenges related to the wireless medium are appearing, the methodologies for designing system architectures are substantially remaining the same. Under the increasing pressure of market...... the traditional protocol stack design methodology. However, Cross Layer also carries a risk due to possibly unexpected and undesired effects. In this chapter we want to provide architecture designers with a set of tools and recommendations synthesized from an analysis of the state of art, but enriched...

  19. Virtual Reality as Innovative Approach to the Interior Designing

    Directory of Open Access Journals (Sweden)

    Kaleja Pavol

    2017-06-01

    Full Text Available We can observe significant potential of information and communication technologies (ICT in interior designing field, by development of software and hardware virtual reality tools. Using ICT tools offer realistic perception of proposal in its initial idea (the study. A group of real-time visualization, supported by hardware tools like Oculus Rift HTC Vive, provides free walkthrough and movement in virtual interior with the possibility of virtual designing. By improving of ICT software tools for designing in virtual reality we can achieve still more realistic virtual environment. The contribution presented proposal of an innovative approach of interior designing in virtual reality, using the latest software and hardware ICT virtual reality technologies

  20. Design of an Evolutionary Approach for Intrusion Detection

    Science.gov (United States)

    2013-01-01

    A novel evolutionary approach is proposed for effective intrusion detection based on benchmark datasets. The proposed approach can generate a pool of noninferior individual solutions and ensemble solutions thereof. The generated ensembles can be used to detect the intrusions accurately. For intrusion detection problem, the proposed approach could consider conflicting objectives simultaneously like detection rate of each attack class, error rate, accuracy, diversity, and so forth. The proposed approach can generate a pool of noninferior solutions and ensembles thereof having optimized trade-offs values of multiple conflicting objectives. In this paper, a three-phase, approach is proposed to generate solutions to a simple chromosome design in the first phase. In the first phase, a Pareto front of noninferior individual solutions is approximated. In the second phase of the proposed approach, the entire solution set is further refined to determine effective ensemble solutions considering solution interaction. In this phase, another improved Pareto front of ensemble solutions over that of individual solutions is approximated. The ensemble solutions in improved Pareto front reported improved detection results based on benchmark datasets for intrusion detection. In the third phase, a combination method like majority voting method is used to fuse the predictions of individual solutions for determining prediction of ensemble solution. Benchmark datasets, namely, KDD cup 1999 and ISCX 2012 dataset, are used to demonstrate and validate the performance of the proposed approach for intrusion detection. The proposed approach can discover individual solutions and ensemble solutions thereof with a good support and a detection rate from benchmark datasets (in comparison with well-known ensemble methods like bagging and boosting). In addition, the proposed approach is a generalized classification approach that is applicable to the problem of any field having multiple conflicting

  1. Design of an evolutionary approach for intrusion detection.

    Science.gov (United States)

    Kumar, Gulshan; Kumar, Krishan

    2013-01-01

    A novel evolutionary approach is proposed for effective intrusion detection based on benchmark datasets. The proposed approach can generate a pool of noninferior individual solutions and ensemble solutions thereof. The generated ensembles can be used to detect the intrusions accurately. For intrusion detection problem, the proposed approach could consider conflicting objectives simultaneously like detection rate of each attack class, error rate, accuracy, diversity, and so forth. The proposed approach can generate a pool of noninferior solutions and ensembles thereof having optimized trade-offs values of multiple conflicting objectives. In this paper, a three-phase, approach is proposed to generate solutions to a simple chromosome design in the first phase. In the first phase, a Pareto front of noninferior individual solutions is approximated. In the second phase of the proposed approach, the entire solution set is further refined to determine effective ensemble solutions considering solution interaction. In this phase, another improved Pareto front of ensemble solutions over that of individual solutions is approximated. The ensemble solutions in improved Pareto front reported improved detection results based on benchmark datasets for intrusion detection. In the third phase, a combination method like majority voting method is used to fuse the predictions of individual solutions for determining prediction of ensemble solution. Benchmark datasets, namely, KDD cup 1999 and ISCX 2012 dataset, are used to demonstrate and validate the performance of the proposed approach for intrusion detection. The proposed approach can discover individual solutions and ensemble solutions thereof with a good support and a detection rate from benchmark datasets (in comparison with well-known ensemble methods like bagging and boosting). In addition, the proposed approach is a generalized classification approach that is applicable to the problem of any field having multiple conflicting

  2. A Statistical Approach to Implosion Design on the OMEGA Laser

    Science.gov (United States)

    Gopalaswamy, V.; Betti, R.

    2017-10-01

    The 1-D campaign on OMEGA is backed by a novel approach aimed at producing an iterative and data-driven process to design optimized cryogenic implosions and improve the accuracy of 1-D physics models. The process does not preclude the possibility of significant systematic errors on OMEGA, nor does it assume that the hydrodynamic codes used in implosion design have all the necessary physical models. It only assumes that there exists some relationship between simulation and experimental results and uses statistical methods to model this relationship. Comparisons of hydrodynamic simulations of less-accurate physical models with more-accurate ones indicate that as long as equation of state is relatively well modeled, this assumption holds. By incorporating data from over 40 experiments on OMEGA, this approach has been used to design four targets with a two-shock pulse design for the 1-D campaign, and led to pre-shot predictions of yields within 5% and ion temperatures within 3% of the experimental values. One of these implosions has also produced the highest neutron yield (1.1 ×1014) on an OMEGA cryogenic implosion with an areal density of 105mgmgcm cm2 . The region of design space in which the predictive capability of this model is valid remains an open question. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

  3. Cache and memory hierarchy design a performance directed approach

    CERN Document Server

    Przybylski, Steven A

    1991-01-01

    An authoritative book for hardware and software designers. Caches are by far the simplest and most effective mechanism for improving computer performance. This innovative book exposes the characteristics of performance-optimal single and multi-level cache hierarchies by approaching the cache design process through the novel perspective of minimizing execution times. It presents useful data on the relative performance of a wide spectrum of machines and offers empirical and analytical evaluations of the underlying phenomena. This book will help computer professionals appreciate the impact of ca

  4. A Topology Optimisation Approach to Learning in Architectural Design

    DEFF Research Database (Denmark)

    Mullins, Michael; Kirkegaard, Poul Henning; Jessen, Rasmus Zederkof

    2005-01-01

    Topology optimization methods offer an interesting tool for architects and engineers as a rational basis for the choice of a structure’s initial form, particularly as developments in computer software are compatible with this approach. This can be argued from ecology, resource savings, static load...... design, financial and a number of other pragmatic reasons. But in an artistic/architectural perspective these are not decisive. Analogical design qualities include a tectonic appreciation of the properties of materials, metaphoric interpretation of intention and considerations of context. The paper...

  5. A graphical approach to radio frequency quadrupole design

    Science.gov (United States)

    Turemen, G.; Unel, G.; Yasatekin, B.

    2015-07-01

    The design of a radio frequency quadrupole, an important section of all ion accelerators, and the calculation of its beam dynamics properties can be achieved using the existing computational tools. These programs, originally designed in 1980s, show effects of aging in their user interfaces and in their output. The authors believe there is room for improvement in both design techniques using a graphical approach and in the amount of analytical calculations before going into CPU burning finite element analysis techniques. Additionally an emphasis on the graphical method of controlling the evolution of the relevant parameters using the drag-to-change paradigm is bound to be beneficial to the designer. A computer code, named DEMIRCI, has been written in C++ to demonstrate these ideas. This tool has been used in the design of Turkish Atomic Energy Authority (TAEK)'s 1.5 MeV proton beamline at Saraykoy Nuclear Research and Training Center (SANAEM). DEMIRCI starts with a simple analytical model, calculates the RFQ behavior and produces 3D design files that can be fed to a milling machine. The paper discusses the experience gained during design process of SANAEM Project Prometheus (SPP) RFQ and underlines some of DEMIRCI's capabilities.

  6. Designing Course An Initial Approach To Translation Teaching

    Directory of Open Access Journals (Sweden)

    Roswani Siregar

    2017-09-01

    Full Text Available Along with the human history translation is the sustainable communication tool among the cultures to preserve this knowledge from generation to generations. Undoubtedly both translation plays a very important role in an increasingly globalized world and translators have the prominent roles in the development of countries. Many translators really enjoy their work but hesitated to teach a course due to their lack of pedagogical knowledge and believe that the translation skill is gained by personal experiences and talents. Thus this paper attempt to promote the translation teaching in classroom by set the preliminary approach to teach translation. The sequences of teaching design are described by propose the brief definition to the nature of translation the importance translation teaching the translator competence and design of translation course. This paper is the preliminary approach to translation teaching for beginners in university setting.

  7. Pure Quantum Interpretations Are not Viable

    Science.gov (United States)

    Schmelzer, I.

    2011-02-01

    Pure interpretations of quantum theory, which throw away the classical part of the Copenhagen interpretation without adding new structure to its quantum part, are not viable. This is a consequence of a non-uniqueness result for the canonical operators.

  8. Bringing service design to manufacturing companies: integrating PSS and service design approaches

    DEFF Research Database (Denmark)

    Costa, Nina; Patrício, Lia; Morelli, Nicola

    2018-01-01

    a design research methodology and built on Service-Dominant logic, integrating the human-oriented perspective of Service Design with an organizational network-oriented perspective of Product–Service System. It creates a new Integrative PSS approach, evolves design models, and provides an application...... in a manufacturing industry. This paper details how the application supports the design of product–service system solutions from the exploration to the implementation stages, highlighting the physical evidence of service, and contributes to advance design research at the intersection of PSS and Service Design.......Manufacturing companies increasingly try to innovate in their offers to consumers by creating more complete solutions that combine product and service components. However, shifting from a product-centric perspective to a solution-oriented perspective is challenging. The present study adopted...

  9. Revising a design course from a lecture approach to a project-based learning approach

    Science.gov (United States)

    Kunberger, Tanya

    2013-06-01

    In order to develop the evaluative skills necessary for successful performance of design, a senior, Geotechnical Engineering course was revised to immerse students in the complexity of the design process utilising a project-based learning (PBL) approach to instruction. The student-centred approach stresses self-directed group learning, which focuses on the process rather than the result and underscores not only the theoretical but also the practical constraints of a problem. The shift in course emphasis, to skills over concepts, results in reduced content coverage but increased student ability to independently acquire a breadth of knowledge.

  10. Data-Driven Controller Design The H2 Approach

    CERN Document Server

    Sanfelice Bazanella, Alexandre; Eckhard, Diego

    2012-01-01

    Data-driven methodologies have recently emerged as an important paradigm alternative to model-based controller design and several such methodologies are formulated as an H2 performance optimization. This book presents a comprehensive theoretical treatment of the H2 approach to data-driven control design. The fundamental properties implied by the H2 problem formulation are analyzed in detail, so that common features to all solutions are identified. Direct methods (VRFT) and iterative methods (IFT, DFT, CbT) are put under a common theoretical framework. The choice of the reference model, the experimental conditions, the optimization method to be used, and several other designer’s choices are crucial to the quality of the final outcome, and firm guidelines for all these choices are derived from the theoretical analysis presented. The practical application of the concepts in the book is illustrated with a large number of practical designs performed for different classes of processes: thermal, fluid processing a...

  11. Computational design approaches and tools for synthetic biology.

    Science.gov (United States)

    MacDonald, James T; Barnes, Chris; Kitney, Richard I; Freemont, Paul S; Stan, Guy-Bart V

    2011-02-01

    A proliferation of new computational methods and software tools for synthetic biology design has emerged in recent years but the field has not yet reached the stage where the design and construction of novel synthetic biology systems has become routine. To a large degree this is due to the inherent complexity of biological systems. However, advances in biotechnology and our scientific understanding have already enabled a number of significant achievements in this area. A key concept in engineering is the ability to assemble simpler standardised modules into systems of increasing complexity but it has yet to be adequately addressed how this approach can be applied to biological systems. In particular, the use of computer aided design tools is common in other engineering disciplines and it should eventually become centrally important to the field of synthetic biology if the challenge of dealing with the stochasticity and complexity of biological systems can be overcome.

  12. A New Design Approach to game or play based learning

    DEFF Research Database (Denmark)

    Larsen, Lasse Juel

    Abstract: The present paper proposes a new design perspective for game based learning. The general idea is to abandon the long and sought after dream of designing a closed learning system, where students from elementary school to high school without teachers’ interference could learn whatever...... of the average learner from elementary to high school. He or she is often unable to fully grasp, understand or comprehend the learning progress in which he or she is embedded. Portfolios and especially e-portfolios can be used to promote reflections on the both the development and the learning process in order...... to ground the students sense of meaning. This paper proposes another approach: using visualization in immersive 3D-worlds as documentation of learning progress while at the same time constituting a reward system which motivate further learning. The overall design idea is to build a game based learning...

  13. Learning design Rashomon I – supporting the design of one lesson through different approaches

    Directory of Open Access Journals (Sweden)

    Donatella Persico

    2013-08-01

    Full Text Available This paper presents and compares a variety of approaches that have been developed to guide the decision-making process in learning design. Together with the companion Learning Design Rashomon II (Prieto et al., 2013, devoted to existing tools to support the same process, it aims to provide a view on relevant research results in this field. The common thread followed in these two contributions is inspired by Kurosawa's Rashomon film, which takes multiple perspectives on the same action. Similarly, in this paper, Rashomon I, a lesson on “Healthy Eating” is analysed according to five different approaches, while the Rashomon II paper is used to exemplify the affordances of different tools. For this reason, this paper does not follow the conventional structure of research papers (research question, method, results and discussion, but rather it moves from an introduction providing the rationale for the paper, to a description of the five different approaches to learning design (the 4SPPIces Model, the 4Ts, the e-Design Template, the Design Principles Database and the Design Narrative and then to a discussion of their similarities and differences to inform the choice of potential users.

  14. An integrated systems engineering approach to aircraft design

    Science.gov (United States)

    Price, M.; Raghunathan, S.; Curran, R.

    2006-06-01

    The challenge in Aerospace Engineering, in the next two decades as set by Vision 2020, is to meet the targets of reduction of nitric oxide emission by 80%, carbon monoxide and carbon dioxide both by 50%, reduce noise by 50% and of course with reduced cost and improved safety. All this must be achieved with expected increase in capacity and demand. Such a challenge has to be in a background where the understanding of physics of flight has changed very little over the years and where industrial growth is driven primarily by cost rather than new technology. The way forward to meet the challenges is to introduce innovative technologies and develop an integrated, effective and efficient process for the life cycle design of aircraft, known as systems engineering (SE). SE is a holistic approach to a product that comprises several components. Customer specifications, conceptual design, risk analysis, functional analysis and architecture, physical architecture, design analysis and synthesis, and trade studies and optimisation, manufacturing, testing validation and verification, delivery, life cycle cost and management. Further, it involves interaction between traditional disciplines such as Aerodynamics, Structures and Flight Mechanics with people- and process-oriented disciplines such as Management, Manufacturing, and Technology Transfer. SE has become the state-of-the-art methodology for organising and managing aerospace production. However, like many well founded methodologies, it is more difficult to embody the core principles into formalised models and tools. The key contribution of the paper will be to review this formalisation and to present the very latest knowledge and technology that facilitates SE theory. Typically, research into SE provides a deeper understanding of the core principles and interactions, and helps one to appreciate the required technical architecture for fully exploiting it as a process, rather than a series of events. There are major issues as

  15. Development of an mHealth Application for Women Newly Diagnosed with Osteoporosis without Preceding Fractures: A Participatory Design Approach.

    Science.gov (United States)

    Ravn Jakobsen, Pernille; Hermann, Anne Pernille; Søndergaard, Jens; Wiil, Uffe Kock; Clemensen, Jane

    2018-02-13

    mHealth is a useful tool to improve health outcome within chronic disease management. However, mHealth is not implemented in the field of postmenopausal osteoporosis even though it is a major worldwide health challenge. Therefore, this study aims to design and develop an mHealth app to support women in self-management of osteoporosis when they are diagnosed without preceding fractures. Participatory design is conducted in three phases. Based on identified needs in the first phase, a prototype is designed and developed in an iterative process in the second phase before the mHealth app is tested in the third phase. This paper focuses on the user activities in phase two and describes how a team of researchers, women, physicians, healthcare professionals, and app designers are involved in the participatory design process. The study shows that participatory design is a viable approach when developing an mHealth app for women with asymptomatic osteoporosis. Results obtained from the workshops and laboratory tests demonstrate the importance of feedback from users in the iterative process, as well as the participation of users and app designers in workshops and laboratory tests to enable mutual learning when developing new mHealth solutions. The regular member-checks and involvement of users helped to identify challenges associated with providing healthcare services through an app.

  16. Innovative approaches to clinical development and trial design

    Directory of Open Access Journals (Sweden)

    John J Orloff

    2011-01-01

    Full Text Available Pharmaceutical innovation is increasingly risky, costly and at times inefficient, which has led to a decline in industry productivity. Despite the increased investment in R&D by the industry, the number of new molecular entities achieving marketing authorization is not increasing. Novel approaches to clinical development and trial design could have a key role in overcoming some of these challenges by improving efficiency and reducing attrition rates. The effectiveness of clinical development can be improved by adopting a more integrated model that increases flexibility and maximizes the use of accumulated knowledge. Central to this model of drug development are novel tools, including modelling and simulation, Bayesian methodologies, and adaptive designs, such as seamless adaptive designs and sample-size re-estimation methods. Applications of these methodologies to early- and late-stage drug development are described with some specific examples, along with advantages, challenges, and barriers to implementation. Because they are so flexible, these new trial designs require significant statistical analyses, simulations and logistical considerations to verify their operating characteristics, and therefore tend to require more time for the planning and protocol development phase. Greater awareness of the distinct advantages of innovative designs by regulators and sponsors are crucial to increasing the adoption of these modern tools.

  17. Design and Development of a Portable Metal Chip Baler using A System Design Approach

    Directory of Open Access Journals (Sweden)

    Hassan Mohd Fahrul

    2017-01-01

    Full Text Available A large amount of metal chips at workplace will result in untidy and unsafe condition thus measurements of safety are needed in some industries, where the metal chips will be collected and put into a container until the volume is sufficient to be recycled. Due to that reason, the metal chips require a lot of spaces for storage before going to recycle. In this study, a portable metal chip baler as a device for compacting those metal chips is presented based on a system approach of engineering design. Basically, the system design evolves through four phases of development that are started from conceptual design, preliminary system design, detail design and development to system test and evaluation. The portable metal chip baler uses current technology such as pneumatic cylinder to compress the metal chips so that the system capable to operate efficiently. The output from this system is the metal chips are compacted into a block shape and a working prototype was developed to prove the concept of the system. As a summary, the conceptual design of portable metal chip baler was proven and was presented using the philosophy of the systems design approach. This tool may assists workers especially in the Small-Medium Enterprise (SME manufacturing industries, school or universities’ workshops for managing metal chips easily and systematically.

  18. Inviscid/Boundary-Layer Aeroheating Approach for Integrated Vehicle Design

    Science.gov (United States)

    Lee, Esther; Wurster, Kathryn E.

    2017-01-01

    A typical entry vehicle design depends on the synthesis of many essential subsystems, including thermal protection system (TPS), structures, payload, avionics, and propulsion, among others. The ability to incorporate aerothermodynamic considerations and TPS design into the early design phase is crucial, as both are closely coupled to the vehicle's aerodynamics, shape and mass. In the preliminary design stage, reasonably accurate results with rapid turn-representative entry envelope was explored. Initial results suggest that for Mach numbers ranging from 9-20, a few inviscid solutions could reasonably sup- port surface heating predictions at Mach numbers variation of +/-2, altitudes variation of +/-10 to 20 kft, and angle-of-attack variation of +/- 5. Agreement with Navier-Stokes solutions was generally found to be within 10-15% for Mach number and altitude, and 20% for angle of attack. A smaller angle-of-attack increment than the 5 deg around times for parametric studies and quickly evolving configurations are necessary to steer design decisions. This investigation considers the use of an unstructured 3D inviscid code in conjunction with an integral boundary-layer method; the former providing the flow field solution and the latter the surface heating. Sensitivity studies for Mach number, angle of attack, and altitude, examine the feasibility of using this approach to populate a representative entry flight envelope based on a limited set of inviscid solutions. Each inviscid solution is used to generate surface heating over the nearby trajectory space. A subset of a considered in this study is recommended. Results of the angle-of-attack sensitivity studies show that smaller increments may be needed for better heating predictions. The approach is well suited for application to conceptual multidisciplinary design and analysis studies where transient aeroheating environments are critical for vehicle TPS and thermal design. Concurrent prediction of aeroheating

  19. An integrated approach to system design, reliability, and diagnosis

    Science.gov (United States)

    Patterson-Hine, F. A.; Iverson, David L.

    1990-12-01

    The requirement for ultradependability of computer systems in future avionics and space applications necessitates a top-down, integrated systems engineering approach for design, implementation, testing, and operation. The functional analyses of hardware and software systems must be combined by models that are flexible enough to represent their interactions and behavior. The information contained in these models must be accessible throughout all phases of the system life cycle in order to maintain consistency and accuracy in design and operational decisions. One approach being taken by researchers at Ames Research Center is the creation of an object-oriented environment that integrates information about system components required in the reliability evaluation with behavioral information useful for diagnostic algorithms. Procedures have been developed at Ames that perform reliability evaluations during design and failure diagnoses during system operation. These procedures utilize information from a central source, structured as object-oriented fault trees. Fault trees were selected because they are a flexible model widely used in aerospace applications and because they give a concise, structured representation of system behavior. The utility of this integrated environment for aerospace applications in light of our experiences during its development and use is described. The techniques for reliability evaluation and failure diagnosis are discussed, and current extensions of the environment and areas requiring further development are summarized.

  20. A Statistical Approach to Optimizing Concrete Mixture Design

    Directory of Open Access Journals (Sweden)

    Shamsad Ahmad

    2014-01-01

    Full Text Available A step-by-step statistical approach is proposed to obtain optimum proportioning of concrete mixtures using the data obtained through a statistically planned experimental program. The utility of the proposed approach for optimizing the design of concrete mixture is illustrated considering a typical case in which trial mixtures were considered according to a full factorial experiment design involving three factors and their three levels (33. A total of 27 concrete mixtures with three replicates (81 specimens were considered by varying the levels of key factors affecting compressive strength of concrete, namely, water/cementitious materials ratio (0.38, 0.43, and 0.48, cementitious materials content (350, 375, and 400 kg/m3, and fine/total aggregate ratio (0.35, 0.40, and 0.45. The experimental data were utilized to carry out analysis of variance (ANOVA and to develop a polynomial regression model for compressive strength in terms of the three design factors considered in this study. The developed statistical model was used to show how optimization of concrete mixtures can be carried out with different possible options.

  1. A statistical approach to optimizing concrete mixture design.

    Science.gov (United States)

    Ahmad, Shamsad; Alghamdi, Saeid A

    2014-01-01

    A step-by-step statistical approach is proposed to obtain optimum proportioning of concrete mixtures using the data obtained through a statistically planned experimental program. The utility of the proposed approach for optimizing the design of concrete mixture is illustrated considering a typical case in which trial mixtures were considered according to a full factorial experiment design involving three factors and their three levels (3(3)). A total of 27 concrete mixtures with three replicates (81 specimens) were considered by varying the levels of key factors affecting compressive strength of concrete, namely, water/cementitious materials ratio (0.38, 0.43, and 0.48), cementitious materials content (350, 375, and 400 kg/m(3)), and fine/total aggregate ratio (0.35, 0.40, and 0.45). The experimental data were utilized to carry out analysis of variance (ANOVA) and to develop a polynomial regression model for compressive strength in terms of the three design factors considered in this study. The developed statistical model was used to show how optimization of concrete mixtures can be carried out with different possible options.

  2. Participatory knowledge-management design: A semiotic approach

    DEFF Research Database (Denmark)

    Valtolina, Stefano; Barricelli, Barbara Rita; Dittrich, Yvonne

    2012-01-01

    vocabularies, notations, and suitable visual structures for navigating among interface elements. To this end, the paper describes how our semiotic approach supports processes for representing, storing, accessing, and transferring knowledge through which the information architecture of an interactive system can......The aim of this paper is to present a design strategy for collaborative knowledge-management systems based on a semiotic approach. The contents and structure of experts' knowledge is highly dependent on professional or individual practice. Knowledge-management systems that support cooperation......'s communication with herself, himself or other users of the software. Tailoring or “end-user development” – i.e. adapting the knowledge-management system to a specific (sub-)discipline, task or context – then refines both the message and adapts the structure of the interaction to the situated requirements...

  3. Fuzzy Axiomatic Design approach based green supplier selection

    DEFF Research Database (Denmark)

    Kannan, Devika; Govindan, Kannan; Rajendran, Sivakumar

    2015-01-01

    proposes a multi-criteria decision-making (MCDM) approach called Fuzzy Axiomatic Design (FAD) to select the best green supplier for Singapore-based plastic manufacturing company. At first, the environmental criteria was developed along with the traditional criteria based on the literature review...... and company requirements. Next, the FAD methodology evaluates the requirements of both the manufacturer (design needs) and the supplier (functional needs), and because multiple criteria must be considered, a multi-objective optimization model of a fuzzy nature must be developed. The application...... responsible in addition to being efficiently managed. A significant way to implement responsible GSCM is to reconsider, in innovative ways, the purchase and supply cycle, and a preliminary step would be to ensure that the supplier of goods successfully incorporates green criteria. Therefore, this paper...

  4. Designing e-learning solutions with a client centred approach

    DEFF Research Database (Denmark)

    Ørngreen, Rikke; Nielsen, Janni; Levinsen, Karin

    2008-01-01

      This paper claims that the strategies applied in designing e-learning solutions tend to focus on how to proceed after the precondition, e.g., learners requirements, pedagogical choice, etc., have been decided upon. Investigating the HCI research field, we find that the methodological approaches...... as the organisation that has initiated the e-learning project and needs to manage the e-learning system after its development. Through the Client Centred Design and in close collaboration with the client, three strategic issues are uncovered and strategic models are presented for each. These models are complementary...... perspectives in a Client Centred framework that is useable as the starting point for others in developing large scale e-learning projects....

  5. Efficient design of meganucleases using a machine learning approach.

    Science.gov (United States)

    Zaslavskiy, Mikhail; Bertonati, Claudia; Duchateau, Philippe; Duclert, Aymeric; Silva, George H

    2014-06-17

    Meganucleases are important tools for genome engineering, providing an efficient way to generate DNA double-strand breaks at specific loci of interest. Numerous experimental efforts, ranging from in vivo selection to in silico modeling, have been made to re-engineer meganucleases to target relevant DNA sequences. Here we present a novel in silico method for designing custom meganucleases that is based on the use of a machine learning approach. We compared it with existing in silico physical models and high-throughput experimental screening. The machine learning model was used to successfully predict active meganucleases for 53 new DNA targets. This new method shows competitive performance compared with state-of-the-art in silico physical models, with up to a fourfold increase in terms of the design success rate. Compared to experimental high-throughput screening methods, it reduces the number of screening experiments needed by a factor of more than 100 without affecting final performance.

  6. A Morphogenetic Design Approach with Embedded Structural Analysis

    DEFF Research Database (Denmark)

    Jensen, Mads Brath; Kirkegaard, Poul Henning; Holst, Malene Kirstine

    2010-01-01

    The present paper explores a morphogenetic design approach with embedded structural analysis for architectural design. A material system based on a combined space truss and membrane system has been derived as a growth system with inspiration from natural growth of plants. The structural system...... is capable of adding new elements based on a structural analysis of the existing components and their internal stress levels. A GA decision-making procedure that control the generation of the growth cycles is introduced. This evaluation and generation loop is capable of successfully making decisions based...... on several, and often conflicting, inputs formulated from architectural requirements. An experiment with a tri-pyramid component has been considered, but many other space truss systems could be explored in the same manner and result in highly performative outcomes. not only with respect to the structural...

  7. Operating system design the Xinu approach, Linksys version

    CERN Document Server

    Press, CRC

    2011-01-01

    Introduction and OverviewOperating SystemsApproach Used In The TextA Hierarchical DesignThe Xinu Operating SystemWhat An Operating System Is NotAn Operating System Viewed From The OutsideRemainder Of The TextConcurrent Execution And Operating System ServicesProgramming Models For Multiple ActivitiesOperating System ServicesConcurrent Processing Concepts And TerminologyDistinction Between Sequential And Concurrent ProgramsMultiple Processes Sharing A Single Piece Of CodeProcess Exit And Process TerminationShared Memory, Race Conditions, And SynchronizationSemaphores And Mutual ExclusionType Nam

  8. Design of Multithreaded Software The Entity-Life Modeling Approach

    CERN Document Server

    Sandén, Bo I

    2011-01-01

    This book assumes familiarity with threads (in a language such as Ada, C#, or Java) and introduces the entity-life modeling (ELM) design approach for certain kinds of multithreaded software. ELM focuses on "reactive systems," which continuously interact with the problem environment. These "reactive systems" include embedded systems, as well as such interactive systems as cruise controllers and automated teller machines.Part I covers two fundamentals: program-language thread support and state diagramming. These are necessary for understanding ELM and are provided primarily for reference. P

  9. A Multidisciplinary Approach to Mixer-Ejector Analysis and Design

    Science.gov (United States)

    Hendricks, Eric, S.; Seidel, Jonathan, A.

    2012-01-01

    The design of an engine for a civil supersonic aircraft presents a difficult multidisciplinary problem to propulsion system engineers. There are numerous competing requirements for the engine, such as to be efficient during cruise while yet quiet enough at takeoff to meet airport noise regulations. The use of mixer-ejector nozzles presents one possible solution to this challenge. However, designing a mixer-ejector which will successfully address both of these concerns is a difficult proposition. Presented in this paper is an integrated multidisciplinary approach to the analysis and design of these systems. A process that uses several low-fidelity tools to evaluate both the performance and acoustics of mixer-ejectors nozzles is described. This process is further expanded to include system-level modeling of engines and aircraft to determine the effects on mission performance and noise near airports. The overall process is developed in the OpenMDAO framework currently being developed by NASA. From the developed process, sample results are given for a notional mixer-ejector design, thereby demonstrating the capabilities of the method.

  10. Pharmaceutical product development: A quality by design approach.

    Science.gov (United States)

    Pramod, Kannissery; Tahir, M Abu; Charoo, Naseem A; Ansari, Shahid H; Ali, Javed

    2016-01-01

    The application of quality by design (QbD) in pharmaceutical product development is now a thrust area for the regulatory authorities and the pharmaceutical industry. International Conference on Harmonization and United States Food and Drug Administration (USFDA) emphasized the principles and applications of QbD in pharmaceutical development in their guidance for the industry. QbD attributes are addressed in question-based review, developed by USFDA for chemistry, manufacturing, and controls section of abbreviated new drug applications. QbD principles, when implemented, lead to a successful product development, subsequent prompt regulatory approval, reduce exhaustive validation burden, and significantly reduce post-approval changes. The key elements of QbD viz., target product quality profile, critical quality attributes, risk assessments, design space, control strategy, product lifecycle management, and continual improvement are discussed to understand the performance of dosage forms within design space. Design of experiments, risk assessment tools, and process analytical technology are also discussed for their role in QbD. This review underlines the importance of QbD in inculcating science-based approach in pharmaceutical product development.

  11. A Road Map for Knowledge Management Systems Design Using Axiomatic Design Approach

    Directory of Open Access Journals (Sweden)

    Houshmand Mahmoud

    2017-01-01

    Full Text Available Successful design and implementation of knowledge management systems have been the main concern of many researchers. It has been reported that more than 50% of knowledge management systems have failed, therefore, it is required to seek for a new and comprehensive scientific approach to design and implement it. In the design and implementation of a knowledge management system, it is required to know ’what we want to achieve’ and ’how and by what processes we will achieve it’. A literature review conducted and axiomatic design theory selected for this purpose. For the first time, this paper develops a conceptual design of knowledge management systems by means of a hierarchical structure, composed of ’Functional Requirements’ (FRs, ’Design Parameters’ (DPs, and ’Process Variables’ (PVs. The intersection of several studies conducted in the field of knowledge management systems has been used to design the knowledge management model. It reveals that six essential bases of knowledge management are organizational culture, organizational structure, human resources, management and leadership, information technology, and the external environment of the organization; that are represented as top DPs in the structure of the model. These essential factors are decomposed to lower levels by means of zigzagging. The model implemented in Tehran Urban and Suburban Railway Operation Corporation (TUSROC and the results were very promising. The most important result of this study is a roadmap to design successful and efficient knowledge management systems.

  12. COMPARISON OF THE TRADITIONAL STRENGTH OF MATERIALS APPROACH TO DESIGN WITH THE FRACTURE MECHANICS APPROACH

    Energy Technology Data Exchange (ETDEWEB)

    Z. Ceylan

    2002-04-30

    The objective of this activity is to show that the use of the traditional strength of materials approach to the drip shield and the waste package (WP) designs is bounding and appropriate when compared to the fracture mechanics approach. The scope of this activity is limited to determining the failure assessment diagrams for the two materials at issue: Ti-7 and Alloy 22. This calculation is intended for use in support of the license application design of the drip shield and the WP. This activity is associated with the drip shield and the WP designs. The activity evaluation for work package number P32 12234F2, included in ''Technical Work Plan for: Waste Package Design Description for LA'' (Ref. 1, p. A-6), has determined that the development of this document is subject to ''Quality Assurance Requirements and Description'' requirements. The control of the electronic management of data is accomplished in accordance with the methods specified in Reference 1, Section 10. AP-3.124, ''Design Calculations and Analysis'' (Ref. 2), is used to develop and document the calculation.

  13. Factorial Design Approach in Proportioning Prestressed Self-Compacting Concrete

    Directory of Open Access Journals (Sweden)

    Wu-Jian Long

    2015-03-01

    Full Text Available In order to model the effect of mixture parameters and material properties on the hardened properties of, prestressed self-compacting concrete (SCC, and also to investigate the extensions of the statistical models, a factorial design was employed to identify the relative significance of these primary parameters and their interactions in terms of the mechanical and visco-elastic properties of SCC. In addition to the 16 fractional factorial mixtures evaluated in the modeled region of −1 to +1, eight axial mixtures were prepared at extreme values of −2 and +2 with the other variables maintained at the central points. Four replicate central mixtures were also evaluated. The effects of five mixture parameters, including binder type, binder content, dosage of viscosity-modifying admixture (VMA, water-cementitious material ratio (w/cm, and sand-to-total aggregate ratio (S/A on compressive strength, modulus of elasticity, as well as autogenous and drying shrinkage are discussed. The applications of the models to better understand trade-offs between mixture parameters and carry out comparisons among various responses are also highlighted. A logical design approach would be to use the existing model to predict the optimal design, and then run selected tests to quantify the influence of the new binder on the model.

  14. Factorial Design Approach in Proportioning Prestressed Self-Compacting Concrete.

    Science.gov (United States)

    Long, Wu-Jian; Khayat, Kamal Henri; Lemieux, Guillaume; Xing, Feng; Wang, Wei-Lun

    2015-03-13

    In order to model the effect of mixture parameters and material properties on the hardened properties of, prestressed self-compacting concrete (SCC), and also to investigate the extensions of the statistical models, a factorial design was employed to identify the relative significance of these primary parameters and their interactions in terms of the mechanical and visco-elastic properties of SCC. In addition to the 16 fractional factorial mixtures evaluated in the modeled region of -1 to +1, eight axial mixtures were prepared at extreme values of -2 and +2 with the other variables maintained at the central points. Four replicate central mixtures were also evaluated. The effects of five mixture parameters, including binder type, binder content, dosage of viscosity-modifying admixture (VMA), water-cementitious material ratio (w/cm), and sand-to-total aggregate ratio (S/A) on compressive strength, modulus of elasticity, as well as autogenous and drying shrinkage are discussed. The applications of the models to better understand trade-offs between mixture parameters and carry out comparisons among various responses are also highlighted. A logical design approach would be to use the existing model to predict the optimal design, and then run selected tests to quantify the influence of the new binder on the model.

  15. A design thinking approach to effective vaccine safety communication.

    Science.gov (United States)

    Seeber, Lea; Michl, Bettina; Rundblad, Gabriella; Trusko, Brett; Schnjakin, Maxim; Meinel, Christoph; Weinberg, Ulrich; Gaedicke, Gerhard; Rath, Barbara

    2015-01-01

    The highly complex and controversial topic of vaccine safety communication warrants innovative, user-centered solutions that would start with gaining mutual respect while taking into account the needs, concerns and underlying motives of patients, parents and physicians. To this end, a non-profit collaborative project was conducted by The Vienna Vaccine Safety Initiative, an international think tank aiming to promote vaccine safety research and communication, and the School of Design Thinking in Potsdam, Germany, the first school for innovation in Europe. The revolutionary concept of the Design Thinking approach is to group students in small multi-disciplinary teams. As a result they can generate ground-breaking ideas by combining their expertise and different points of view. The team agreed to address the following design challenge question: "How might we enable physicians to encourage parents and children to prevent infectious diseases?" The current article describes, step-by step, the ideation and innovation process as well as first tangible outcomes of the project.

  16. Signage by Design: A Design-Thinking Approach to Library User Experience

    Directory of Open Access Journals (Sweden)

    Edward Luca

    2016-01-01

    Full Text Available Signage is a powerful visual tool for communication and a crucial component of the library user experience. Signage can welcome, guide, instruct, and delight users, helping them navigate the complex information world of any library. In practice, however, signage can be problematic, revealing tensions between various stakeholders, and contributing to visual noise through information overload; this often leads to signage blindness, library anxiety, and confusion. This article explores how libraries can use a design-thinking approach to improve the user experience in physical library spaces, particularly with respect to signage, based on our experience at the UTS Library, a university library in Australia that serves the University of Technology Sydney (UTS. We found that a design-thinking approach that uses the processes of empathy, problem definition, solution ideation, prototyping, and testing, can help libraries make significant and meaningful changes that can be adopted at relatively low cost.

  17. Using Generic Examples to Make Viable Arguments

    Science.gov (United States)

    Adams, Anne E.; Ely, Rob; Yopp, David

    2017-01-01

    The twenty-first century has seen an increased call to train students to craft mathematical arguments. The third of the Common Core's (CCSS) Standards for Mathematical Practice (SMP 3) (CCSSI 2010) calls for all mathematically proficient students to "construct viable arguments" to support the truth of their ideas and to "critique…

  18. Simulation-Driven Design Approach for Design and Optimization of Blankholder

    Science.gov (United States)

    Sravan, Tatipala; Suddapalli, Nikshep R.; Johan, Pilthammar; Mats, Sigvant; Christian, Johansson

    2017-09-01

    Reliable design of stamping dies is desired for efficient and safe production. The design of stamping dies are today mostly based on casting feasibility, although it can also be based on criteria for fatigue, stiffness, safety, economy. Current work presents an approach that is built on Simulation Driven Design, enabling Design Optimization to address this issue. A structural finite element model of a stamping die, used to produce doors for Volvo V70/S80 car models, is studied. This die had developed cracks during its usage. To understand the behaviour of stress distribution in the stamping die, structural analysis of the die is conducted and critical regions with high stresses are identified. The results from structural FE-models are compared with analytical calculations pertaining to fatigue properties of the material. To arrive at an optimum design with increased stiffness and lifetime, topology and free-shape optimization are performed. In the optimization routine, identified critical regions of the die are set as design variables. Other optimization variables are set to maintain manufacturability of the resultant stamping die. Thereafter a CAD model is built based on geometrical results from topology and free-shape optimizations. Then the CAD model is subjected to structural analysis to visualize the new stress distribution. This process is iterated until a satisfactory result is obtained. The final results show reduction in stress levels by 70% with a more homogeneous distribution. Even though mass of the die is increased by 17 %, overall, a stiffer die with better lifetime is obtained. Finally, by reflecting on the entire process, a coordinated approach to handle such situations efficiently is presented.

  19. An integrated approach to route selection in slurry pipeline design

    Energy Technology Data Exchange (ETDEWEB)

    Betinol, Roy G.; Altmann, Nara [Brass Chile S.A., Santiago (Chile)

    2009-12-19

    The pressure to get engineering projects done and constructed as fast as possible in order to take advantage of the high prices in metals and petrochemicals has been driving companies to skip the conceptual phase and go straight into basic engineering with cost estimates in the level of 15% accuracy. By-passing early engineering and demanding higher cost estimating accuracy is a contradiction. In most cases, savings made on capital investment is much higher had money been spent in conceptual studies which allow for the optimal solution to be found. This paper reviews one of the key aspects in conceptual engineering of slurry pipeline designs: route selection. This activity is often overlooked, causing capital cost and operating difficulties to rise unnecessarily. This paper describes and gives example on how an integrated client/engineering company's approach to route selection can produce significant savings in pipeline construction and operating costs. (author)

  20. Computer Forensics for Graduate Accountants: A Motivational Curriculum Design Approach

    Directory of Open Access Journals (Sweden)

    Grover Kearns

    2010-06-01

    Full Text Available Computer forensics involves the investigation of digital sources to acquire evidence that can be used in a court of law. It can also be used to identify and respond to threats to hosts and systems. Accountants use computer forensics to investigate computer crime or misuse, theft of trade secrets, theft of or destruction of intellectual property, and fraud. Education of accountants to use forensic tools is a goal of the AICPA (American Institute of Certified Public Accountants. Accounting students, however, may not view information technology as vital to their career paths and need motivation to acquire forensic knowledge and skills. This paper presents a curriculum design methodology for teaching graduate accounting students computer forensics. The methodology is tested using perceptions of the students about the success of the methodology and their acquisition of forensics knowledge and skills. An important component of the pedagogical approach is the use of an annotated list of over 50 forensic web-based tools.

  1. Structural genomics: the ultimate approach for rational drug design.

    Science.gov (United States)

    Lundstrom, Kenneth

    2006-10-01

    Structural genomics can be defined as structural biology on a large number of target proteins in parallel. This approach plays an important role in modern structure-based drug design. Although a number of structural genomics initiatives have been initiated, relatively few are associated with integral membrane proteins. This indicates the difficulties in expression, purification, and crystallization of membrane proteins, which has also been confirmed by the existence of some 100 high-resolution structures of membrane proteins among the more than 30,000 entries in public databases. Paradoxically, membrane proteins represent 60-70% of current drug targets and structural knowledge could both improve and speed up the drug discovery process. In order to improve the success rate for structure resolution of membrane proteins structural genomics networks have been established.

  2. A product-service system approach to telehealth application design.

    Science.gov (United States)

    Flores-Vaquero, Paul; Tiwari, Ashutosh; Alcock, Jeffrey; Hutabarat, Windo; Turner, Chris

    2016-06-01

    A considerable proportion of current point-of-care devices do not offer a wide enough set of capabilities if they are to function in any telehealth system. There is a need for intermediate devices that lie between healthcare devices and service networks. The development of an application is suggested that allows for a smartphone to take the role of an intermediate device. This research seeks to identify the telehealth service requirements for long-term condition management using a product-service system approach. The use of product-service system has proven to be a suitable methodology for the design and development of telehealth smartphone applications. © The Author(s) 2014.

  3. A design thinking approach to evaluating interprofessional education.

    Science.gov (United States)

    Cahn, Peter S; Bzowyckyj, Andrew; Collins, Lauren; Dow, Alan; Goodell, Kristen; Johnson, Alex F; Klocko, David; Knab, Mary; Parker, Kathryn; Reeves, Scott; Zierler, Brenda K

    2016-05-01

    The complex challenge of evaluating the impact of interprofessional education (IPE) on patient and community health outcomes is well documented. Recently, at the Radcliffe Institute for Advanced Study in the United States, leaders in health professions education met to help generate a direction for future IPE evaluation research. Participants followed the stages of design thinking, a process for human-centred problem solving, to reach consensus on recommendations. The group concluded that future studies should focus on measuring an intermediate step between learning activities and patient outcomes. Specifically, knowing how IPE-prepared students and preceptors influence the organisational culture of a clinical site as well as how the culture of clinical sites influences learners' attitudes about collaborative practice will demonstrate the value of educational interventions. With a mixed methods approach and an appreciation for context, researchers will be able to identify the factors that foster effective collaborative practice and, by extension, promote patient-centred care.

  4. Design of Dependable Control System Using a Component Based Approach

    DEFF Research Database (Denmark)

    Blanke, M.

    1995-01-01

    Design of fault handling in control systems is discussed and a consistent method for design is presented.......Design of fault handling in control systems is discussed and a consistent method for design is presented....

  5. Learning from nature - novel synthetic biology approaches for biomaterial design.

    Science.gov (United States)

    Bryksin, Anton V; Brown, Ashley C; Baksh, Michael M; Finn, M G; Barker, Thomas H

    2014-04-01

    Many biomaterials constructed today are complex chemical structures that incorporate biologically active components derived from nature, but the field can still be said to be in its infancy. The need for materials that bring sophisticated properties of structure, dynamics and function to medical and non-medical applications will only grow. Increasing appreciation of the functionality of biological systems has caused biomaterials researchers to consider nature for design inspiration, and many examples exist of the use of biomolecular motifs. Yet evolution, nature's only engine for the creation of new designs, has been largely ignored by the biomaterials community. Molecular evolution is an emerging tool that enables one to apply nature's engineering principles to non-natural situations using variation and selection. The purpose of this review is to highlight the most recent advances in the use of molecular evolution in synthetic biology applications for biomaterial engineering, and to discuss some of the areas in which this approach may be successfully applied in the future. Copyright © 2014 Acta Materialia Inc. All rights reserved.

  6. INSCAN PRO: a fast ultraviolet spectrometer design approach

    Science.gov (United States)

    Myer, Brian Walker; Dias, João. Mendanha

    2013-11-01

    Spectroscopy diagnostic techniques have applications in such diverse areas as mechanical and aerospace engineering, physical chemistry, optics, food and pharmaceutical industries. However, the technological state-of-the-art spectrometers do not allow very fast processes to be evaluated or controlled. This ability is crucial in the optimization of industrial processes (welding, burning flames, spark ignition, pulsed radiolysis…) where more theoretical-experimental analysis should be performed. The INSCAN project aims to overcome this technological limitation, to satisfy needs in academia and industrial markets, by developing a compact spectrometer with focal lengths less than 200 mm, taking into account three important aspects: acquisition rate of approximately 10 kHz spectra, spectral resolution on the order of 0.1 nm and operating in the spectral range 200 nm to 700 nm. Initial work is described on the optical design of the device and several possible approaches to achieve the specifications are considered. To guide the first order design, we relate the optical linewidth, spectral bandwidth and imaging properties to component characteristics. The symmetrical Czerny-Turner optical mount was chosen for its flexibility and elaborated using ZEMAX. Predictions made based on the simulated system are compared with calibration and characterization measurements on an experimental test bench used to refine the model assumptions.

  7. Electrostatic Discharge Current Linear Approach and Circuit Design Method

    Energy Technology Data Exchange (ETDEWEB)

    Katsivelis, Pavlos K.; Fotis, Georgios P.; Gonos, Ioannis F.; Koussiouris, Tryfon, G.; Stathopulos, Ioannis A. [School of Electrical and Computer Engineering, National Technical University of Athens (Greece)

    2010-10-15

    The Electrostatic Discharge phenomenon is a great threat to all electronic devices and ICs. An electric charge passing rapidly from a charged body to another can seriously harm the last one. However, there is a lack in a linear mathematical approach which will make it possible to design a circuit capable of producing such a sophisticated current waveform. The commonly accepted Electrostatic Discharge current waveform is the one set by the IEC 61000-4-2. However, the over-simplified circuit included in the same standard is incapable of producing such a waveform. Treating the Electrostatic Discharge current waveform of the IEC 61000-4-2 as reference, an approximation method, based on Prony’s method, is developed and applied in order to obtain a linear system’s response. Considering a known input, a method to design a circuit, able to generate this ESD current waveform in presented. The circuit synthesis assumes ideal active elements. A simulation is carried out using the PSpice software.

  8. Electrostatic discharge current linear approach and circuit design method

    Energy Technology Data Exchange (ETDEWEB)

    Katsivelis, P. K.; Fotis, G. P.; Gonos, I. F.; Koussiouris, T. G.; Stathopulos, I. A. [School of Electrical and Computer Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str., Zographou 157 80, Athens (Greece)

    2010-11-15

    The electrostatic discharge (ESD) phenomenon is a great threat to all electronic devices and ICs. An electric charge passing rapidly from a charged body to another can seriously harm the last one. However, there is a lack in a linear mathematical approach which will make it possible to design a circuit capable of producing such a sophisticated current waveform. The commonly accepted electrostatic discharge current waveform is the one set by the IEC 61000-4-2. However, the over-simplified circuit included in the same standard is incapable of producing such a waveform. Treating the electrostatic discharge current waveform of the IEC 61000-4-2 as reference, an approximation method, based on Prony's method, is developed and applied in order to obtain a linear system's response. Considering a known input, a method to design a circuit, able to generate this ESD current waveform in presented. The circuit synthesis assumes ideal active elements. A simulation is carried out using the PSpice software. (authors)

  9. Behavioral modeling approach for optical communication network design

    Science.gov (United States)

    Vuorinen, Kimmo; Jacquemod, Gilles; Gaffiot, Frederic; Seassal, Christian

    1997-12-01

    An optical communication networks can be divided in two levels: communication level, which defines the protocols, the control and the management of the networks and physical level formed by photonic and electronic components in order to transmit and receive the data between different nodes of the network. Traditionally, these two levels are considered separately in the optical communication network design process. This can lead to an erroneous or non-ideal networks implementation, due to the fact that the communication and physical levels are not independent. For example, in WDM communication network the maximum achievable data rate is limited not only by the networks protocol, but depends also on the implementation of the physical level: tuning delay of the optical multiplexers. Also the lack of the possibilities for co-verification of the communication and the physical levels together could lead to misinterpretations between the designers of the different levels and thus induce design faults. Since the prototyping is extremely expensive and time consuming, an integrated simulation of both communication and physical levels is necessary, at least in some extend. In this paper, a behavioral modeling approach that allows a co- simulation of the communication and the physical levels is presented. It is based on the use of a VHDL-AMS-like hardware description language, dedicated to electronic system modeling, but also suitable for modeling and simulation of non- electronic and mixed-domain systems. The behavioral models for photonic and electronic components, as well as the software are integrated in a unique simulator in order to co-simulate the communication (control) and the physical level (data path) of a WDM optical communication network.

  10. The GEM fault database: an update on design and approach

    Science.gov (United States)

    Gould, M.; Grant, L.; Donnellan, A.; McLeod, D.

    2003-04-01

    We are developing a fault database for California, USA that includes geological and paleoseismic data. This abstract describes our approach to designing the database. The fault database is part of a larger database system that must manage a variety of types of earthquake science data and information. One of the most critical aspects of our proposed system is that it must support interoperability for a variety of application programs, tools, and simulation packages, as well as heterogeneous data. Our system must also be designed to handle real and simulated data. For hypothesis testing and predictive simulation, it is important to separate nonprimary parameters from primary observations, and to know the source of input data. Our goal is to design and develop a database that includes primary geologic and paleoseismic fault parameters, as well as separate nonprimary fault parameters, with all data referenced to the original source. The fault database should accommodate primary observational parameters such as fault location and geometry, kinematic indicators, slip rate, rupture history and recurrence observations, and measurements of displacement. Nonprimary parameters include fault names, strand names, segments, characteristic recurrence interval, and magnitude. Our database will include simulated faults, mapped faults, and hypothesized faults for testing through our simulations. The separation of primary and nonprimary data will allow assimilation of data into models with minimal bias. An XML scheme will be utilized to describe parameters of faults and input data. The fault database will eventually be supported by a state-of-the-art commercially-available general-purpose database management system (DBMS). Initially, our database system will be developed on a public domain DBMS. We have developed extended entity relationships, which will be mapped to a relational database and will initially be implemented in MySQL.

  11. A biomimetic approach for designing stent-graft structures: Caterpillar cuticle as design model.

    Science.gov (United States)

    Singh, Charanpreet; Wang, Xungai

    2014-02-01

    Stent-graft (SG) induced biomechanical mismatch at the aortic repair site forms the major reason behind postoperative hemodynamic complications. These complications arise from mismatched radial compliance and stiffness property of repair device relative to native aortic mechanics. The inability of an exoskeleton SG design (an externally stented rigid polyester graft) to achieve optimum balance between structural robustness and flexibility constrains its biomechanical performance limits. Therefore, a new SG design capable of dynamically controlling its stiffness and flexibility has been proposed in this study. The new design is adopted from the segmented hydroskeleton structure of a caterpillar cuticle and comprises of high performance polymeric filaments constructed in a segmented knit architecture. Initially, conceptual design models of caterpillar and SG were developed and later translated into an experimental SG prototype. The in-vitro biomechanical evaluation (compliance, bending moment, migration intensity, and viscoelasticity) revealed significantly better performance of hydroskeleton structure than a commercial SG device (Zenith(™) Flex SG) and woven Dacron(®) graft-prosthesis. Structural segmentation improved the biomechanical behaviour of new SG by inducing a three dimensional volumetric expansion property when the SG was subjected to hoop stresses. Interestingly, this behaviour matches the orthotropic elastic property of native aorta and hence proposes segmented hydroskeleton structures as promising design approach for future aortic repair devices. © 2013 Published by Elsevier Ltd.

  12. Design and optimization of bilayered tablet of Hydrochlorothiazide using the Quality-by-Design approach

    Science.gov (United States)

    Dholariya, Yatin N; Bansod, Yogesh B; Vora, Rahul M; Mittal, Sandeep S; Shirsat, Ajinath Eknath; Bhingare, Chandrashekhar L

    2014-01-01

    Aim: The aim of the present study is to develop an optimize bilayered tablet using Hydrochlorothiazide (HCTZ) as a model drug candidate using quality by design (QbD) approach. Introduction and Method: The bilayered tablet gives biphasic drug release through loading dose; prepared using croscarmellose sodium a superdisintegrant and maintenance dose using several viscosity grades of hydrophilic polymers. The fundamental principle of QbD is to demonstrate understanding and control of pharmaceutical processes so as to deliver high quality pharmaceutical products with wide opportunities for continuous improvement. Risk assessment was carried out and subsequently 22 factorial designs in duplicate was selected to carry out design of experimentation (DOE) for evaluating the interactions and effects of the design factors on critical quality attribute. The design space was obtained by applying DOE and multivariate analysis, so as to ensure desired disintegration time (DT) and drug release is achieved. Bilayered tablet were evaluated for hardness, thickness, friability, drug content uniformity and in vitro drug dissolution. Result: Optimized formulation obtained from the design space exhibits DT of around 70 s, while DR T95% (time required to release 95% of the drug) was about 720 min. Kinetic studies of formulations revealed that erosion is the predominant mechanism for drug release. Conclusion: From the obtained results; it was concluded that independent variables have a significant effect over the dependent responses, which can be deduced from half normal plots, pareto charts and surface response graphs. The predicted values matched well with the experimental values and the result demonstrates the feasibility of the design model in the development and optimization of HCTZ bilayered tablet. PMID:25006554

  13. Monotone viable trajectories for functional differential inclusions

    Science.gov (United States)

    Haddad, Georges

    This paper is a study on functional differential inclusions with memory which represent the multivalued version of retarded functional differential equations. The main result gives a necessary and sufficient equations. The main result gives a necessary and sufficient condition ensuring the existence of viable trajectories; that means trajectories remaining in a given nonempty closed convex set defined by given constraints the system must satisfy to be viable. Some motivations for this paper can be found in control theory where F( t, φ) = { f( t, φ, u)} uɛU is the set of possible velocities of the system at time t, depending on the past history represented by the function φ and on a control u ranging over a set U of controls. Other motivations can be found in planning procedures in microeconomics and in biological evolutions where problems with memory do effectively appear in a multivalued version. All these models require viability constraints represented by a closed convex set.

  14. Usage-Centered Design Approach in Design of Malaysia Sexuality Education (MSE) Courseware

    Science.gov (United States)

    Chan, S. L.; Jaafar, A.

    The problems amongst juveniles increased every year, especially rape case of minor. Therefore, the government of Malaysia has introduced the National Sexuality Education Guideline on 2005. An early study related to the perception of teachers and students toward the sexuality education curriculum taught in secondary schools currently was carried out in 2008. The study showed that there are big gaps between the perception of the teachers and the students towards several issues of Malaysia sexuality education today. The Malaysia Sexuality Education (MSE) courseware was designed based on few learning theories approach. Then MSE was executed through a comprehensive methodology which the model ADDIE integrated with Usage-Centered Design to achieve high usability courseware. In conclusion, the effort of developing the MSE is hopefully will be a solution to the current problem that happens in Malaysia sexuality education now.

  15. Shared Emotional Values in Sustainable Clothing Design Approaches

    DEFF Research Database (Denmark)

    Durrani, Marium; Petersen, Louise Ravnløkke Munk; Niinimäki, Kirsi

    2016-01-01

    Recent sustainable initiatives in fashion companies are framing design practices that challenge the traditional role of clothing designers. This preliminary study aims to open discussion on challenging traditional clothing design, through an exploration of the shared emotional values between user...

  16. A social sustainability approach to birth environment design

    DEFF Research Database (Denmark)

    Jangaard, Karin; Folmer, Mette Blicher

    2016-01-01

    RESEARCH PROCESS Measuring on welness, lifequality and experience of user involvement in all processes. DESIGN PROCESS Research and design thinking USERINVOLVEMENT Ownership of design solutions CARE MODEL / ORGANISATION Humanity, vison for care and tre...

  17. A social sustainability approach to birth environment design

    DEFF Research Database (Denmark)

    Jangaard, Karin; Folmer, Mette Blicher

    RESEARCH PROCESS Measuring on welness, lifequality and experience of user involvement in all processes. DESIGN PROCESS Research and design thinking USERINVOLVEMENT Ownership of design solutions CARE MODEL / ORGANISATION Humanity, vison for care and tre......RESEARCH PROCESS Measuring on welness, lifequality and experience of user involvement in all processes. DESIGN PROCESS Research and design thinking USERINVOLVEMENT Ownership of design solutions CARE MODEL / ORGANISATION Humanity, vison for care and tre...

  18. A general approach for optimal kinematic design of 6-DOF parallel ...

    Indian Academy of Sciences (India)

    Optimal kinematic design of parallel manipulators is a challenging problem. In this work, an attempt has been made to present a generalized approach of kinematic design for a 6-legged parallel manipulator, by considering only the minimally required design parameters. The same approach has been used to design a ...

  19. Molecular Dynamics Approach in Designing Thermostable Aspergillus niger Xylanase

    Science.gov (United States)

    Malau, N. D.; Sianturi, M.

    2017-03-01

    Molecular dynamics methods we have applied as a tool in designing thermostable Aspergillus niger Xylanase, by examining Root Mean Square Deviation (RMSD) and The Stability of the Secondary Structure of enzymes structure at its optimum temperature and compare with its high temperature behavior. As RMSD represents structural fluctuation at a particular temperature, a better understanding of this factor will suggest approaches to bioengineer these enzymes to enhance their thermostability. In this work molecular dynamic simulations of Aspergillus niger xylanase (ANX) have been carried at 400K (optimum catalytic temperature) for 2.5 ns and 500K (ANX reported inactive temperature) for 2.5 ns. Analysis have shown that the Root Mean Square Deviation (RMSD) significant increase at higher temperatures compared at optimum temperature and some of the secondary structures of ANX that have been damaged at high temperature. Structural analysis revealed that the fluctuations of the α-helix and β-sheet regions are larger at higher temperatures compared to the fluctuations at optimum temperature.

  20. Designing Digital Preservation Solutions: A Risk Management-Based Approach

    Directory of Open Access Journals (Sweden)

    José Barateiro

    2010-07-01

    Full Text Available Digital preservation aims to keep digital objects accessible over long periods of time, ensuring the authenticity and integrity of these digital objects. In such complex environments, Risk Management is a key factor in assuring the normal behaviour of systems over time. Currently, the digital preservation arena commonly uses Risk Management concepts to assess repositories. In this paper, we intend to go further and propose a perspective where Risk Management can be used not only to assess existing solutions, but also to conceive digital preservation environments. Thus, we propose a Risk Management-based approach to design and assess digital preservation environments, including:• the definition of context and identification of strategic objectives to determine specific requirements and characterize which consequences are acceptable within the identified context;• the identification, analysis and evaluation of threats and vulnerabilities that may affect the normal behaviour of a specific business or the achievement of the goals and conformance to the requirements identified in the context characterization; and, • definition of actions to deal with the risks associated with the identified threats and vulnerabilities.We generalize and survey the main requirements, threats, vulnerabilities and techniques that can be applied in the scope of digital preservation.

  1. Design of natural food antioxidant ingredients through a chemometric approach.

    Science.gov (United States)

    Mendiola, Jose A; Martín-Alvarez, Pedro J; Señoráns, F Javier; Reglero, Guillermo; Capodicasa, Alessandro; Nazzaro, Filomena; Sada, Alfonso; Cifuentes, Alejandro; Ibáñez, Elena

    2010-01-27

    In the present work, an environmentally friendly extraction process using subcritical conditions has been tested to obtain potential natural food ingredients from natural sources such as plants, fruits, spirulina, propolis, and tuber, with the scope of substituting synthetic antioxidants, which are subject to regulation restrictions and might be harmful for human health. A full characterization has been undertaken from the chemical and biochemical point of view to be able to understand their mechanism of action. Thus, an analytical method for profiling the compounds responsible for the antioxidant activity has been used, allowing the simultaneous determination of water-soluble vitamins, fat-soluble vitamins, phenolic compounds, carotenoids, and chlorophylls in a single run. This information has been integrated and analyzed using a chemometrical approach to correlate the bioactive compounds profile with the antioxidant activity and thus to be able to predict antioxidant activities of complex formulations. As a further step, a simplex centroid mixture design has been tested to find the optimal formulation and to calculate the effect of the interaction among individual extracts in the mixture.

  2. Beyond podcasting: creative approaches to designing educational audio

    Directory of Open Access Journals (Sweden)

    Andrew Middleton

    2009-12-01

    Full Text Available This paper discusses a university-wide pilot designed to encourage academics to creatively explore learner-centred applications for digital audio. Participation in the pilot was diverse in terms of technical competence, confidence and contextual requirements and there was little prior experience of working with digital audio. Many innovative approaches were taken to using audio in a blended context including student-generated vox pops, audio feedback models, audio conversations and task-setting. A podcast was central to the pilot itself, providing a common space for the 25 participants, who were also supported by materials in several other formats. An analysis of podcast interviews involving pilot participants provided the data informing this case study. This paper concludes that audio has the potential to promote academic creativity in engaging students through media intervention. However, institutional scalability is dependent upon the availability of suitable timely support mechanisms that can address the lack of technical confidence evident in many staff. If that is in place, audio can be widely adopted by anyone seeking to add a new layer of presence and connectivity through the use of voice.

  3. A Graph Rewriting Approach for Transformational Design of Digital Systems

    NARCIS (Netherlands)

    Huijs, C.

    1996-01-01

    Transformational design integrates design and verification. It combines “correctness by construction” and design creativity by the use of pre-proven behaviour preserving transformations as design steps. The formal aspects of this methodology are hidden in the transformations. A constraint is the

  4. A Contradiction-Based Approach for Innovative Product Design

    Directory of Open Access Journals (Sweden)

    Ko Yao-Tsung

    2016-01-01

    Full Text Available Without creativity in design there is no potential for innovation. This paper investigates the role of contradictions in enhancing creativity in product design. Based on the inventive principles of TRIZ, this paper presents a novel design method by integrating technical and physical contradiction analysis methods into the conceptual design activities of new product development (NPD. Despite the recognized importance of innovative design, there is a lack of the systematic and effective design-thinking process that can covers all conceptual design activities. To address this gap, a sharper and fundamental model of the problem-solving is created for innovative product design based on the contradiction-oriented concept. Eventually, one case study is employed to illustrate the method and the result validates that it can help designers produce more creative outcomes in product design.

  5. Air-spore in Cartagena, Spain: viable and non-viable sampling methods.

    Science.gov (United States)

    Elvira-Rendueles, Belen; Moreno, Jose; Garcia-Sanchez, Antonio; Vergara, Nuria; Martinez-Garcia, Maria Jose; Moreno-Grau, Stella

    2013-01-01

    In the presented study the airborne fungal spores of the semiarid city of Cartagena, Spain, are identified and quantified by means of viable or non-viable sampling methods. Airborne fungal samples were collected simultaneously using a filtration method and a pollen and particle sampler based on the Hirst methodology. This information is very useful for elucidating geographical patterns of hay fever and asthma. The qualitative results showed that when the non-viable methodology was employed, Cladosporium, Ustilago, and Alternaria were the most abundant spores identified in the atmosphere of Cartagena, while the viable methodology showed that the most abundant taxa were: Cladosporium, Penicillium, Aspergillus and Alternaria. The quantitative results of airborne fungal spores identified by the Hirst-type air sampler (non-viable method), showed that Deuteromycetes represented 74% of total annual spore counts, Cladosporium being the major component of the fungal spectrum (62.2%), followed by Alternaria (5.3%), and Stemphylium (1.3%). The Basidiomycetes group represented 18.9% of total annual spore counts, Ustilago (7.1%) being the most representative taxon of this group and the second most abundant spore type. Ascomycetes accounted for 6.9%, Nectria (2.3%) being the principal taxon. Oomycetes (0.2%) and Zygomycestes and Myxomycestes (0.06%) were scarce. The prevailing species define our bioaerosol as typical of dry air. The viable methodology was better at identifying small hyaline spores and allowed for the discrimination of the genus of some spore types. However, non-viable methods revealed the richness of fungal types present in the bioaerosol. Thus, the use of both methodologies provides a more comprehensive characterization of the spore profile.

  6. Explaining the Criteria of Designing Urban Furniture and Landscape, with a Cultural-social Design Approach

    Directory of Open Access Journals (Sweden)

    Marzieh Allahdadi

    2017-09-01

    Full Text Available Attention to the deep relationship between human personality and the place in which he lives causes the place to play a crucial role in cultural transformations and prevalence of human life style and formation of values, connections and human activities. Cities are not just a place of transit, but they are also environments that must have mutual communications with the inhabitants in order to realize the meaning of citizen, as there is a distinction between the status of citizenship and urbanization. Urban furniture is one of the elements of urban space that its quantity, beauty and durability play a major role in achieving a healthy and favorable city and satisfies the needs of citizens in terms of performance and beauty. Accordingly, the present study, using descriptive-analytical method and with data collection tools including library and documentary studies, examines the concept of product ecology and answers to the questions whether urban furniture can start or support social interaction or positively affect the roles of citizens? In this paper, the relationship between social-cultural design in urban furniture and the disturbances regarding uneven distribution of elements are identified, and finally the criteria of designing urban furniture and landscape are expressed with a social-design approach.

  7. Parejas viables que perduran en el tiempo

    OpenAIRE

    Juan José Cuervo Rodríguez

    2013-01-01

    El presente artículo científico presenta resultados del proceso llevado a cabo en el proyecto de investigación docente "Mecanismos de autorregulación en parejas viables que perduran en el tiempo". Se soporta en una mirada compleja de la psicología basada en una epistemología de la construcción. En el ámbito metodológico, se inscribe en los estudios de terapia familiar desde una perspectiva de la comunicación humana como un todo integrado. Participaron nueve parejas. Los criterios de inclusión...

  8. Evaluation of vertical profiles to design continuous descent approach procedure

    Science.gov (United States)

    Pradeep, Priyank

    The current research focuses on predictability, variability and operational feasibility aspect of Continuous Descent Approach (CDA), which is among the key concepts of the Next Generation Air Transportation System (NextGen). The idle-thrust CDA is a fuel economical, noise and emission abatement procedure, but requires increased separation to accommodate for variability and uncertainties in vertical and speed profiles of arriving aircraft. Although a considerable amount of researches have been devoted to the estimation of potential benefits of the CDA, only few have attempted to explain the predictability, variability and operational feasibility aspect of CDA. The analytical equations derived using flight dynamics and Base of Aircraft and Data (BADA) Total Energy Model (TEM) in this research gives insight into dependency of vertical profile of CDA on various factors like wind speed and gradient, weight, aircraft type and configuration, thrust settings, atmospheric factors (deviation from ISA (DISA), pressure and density of the air) and descent speed profile. Application of the derived equations to idle-thrust CDA gives an insight into sensitivity of its vertical profile to multiple factors. This suggests fixed geometric flight path angle (FPA) CDA has higher degree of predictability and lesser variability at the cost of non-idle and low thrust engine settings. However, with optimized design this impact can be overall minimized. The CDA simulations were performed using Future ATM Concept Evaluation Tool (FACET) based on radar-track and aircraft type data (BADA) of the real air-traffic to some of the busiest airports in the USA (ATL, SFO and New York Metroplex (JFK, EWR and LGA)). The statistical analysis of the vertical profiles of CDA shows 1) mean geometric FPAs derived from various simulated vertical profiles are consistently shallower than 3° glideslope angle and 2) high level of variability in vertical profiles of idle-thrust CDA even in absence of

  9. Design and Evaluation of Two Blended Learning Approaches: Lessons Learned

    Science.gov (United States)

    Cheung, Wing Sum; Hew, Khe Foon

    2011-01-01

    In this paper, we share two blended learning approaches used at the National Institute of Education in Singapore. We have been using these two approaches in the last twelve years in many courses ranging from the diploma to graduate programs. For the first blended learning approach, we integrated one asynchronous communication tool with face to…

  10. DESIGNING COMPANY PERFORMANCE MEASUREMENT SYSTEM USING BALANCE SCORECARD APPROACH

    Directory of Open Access Journals (Sweden)

    Cecep Mukti Soleh

    2015-05-01

    Full Text Available This research aimed to design how to measure company performance by using balance scorecard approach in coal transportation services industry. Depth interview was used to obtain qualitative data determination of strategic objectives, key performance indicators, strategic initiatives, and in charge units for each balanced scorecard perspectives while the quantitative data were obtained from weighting through questionnaires and analyzed using paired comparison to get a perspective what mostly affected the performance of the company. To measure the achievement of corporate performance, each KPI used (1 the scoring system with the methods that higher is better, lower is better and precise is better; (2 traffic light system with the help of green, yellow, red for identification of target achievement. This research result shows that in the balance scorecard perspective, the most influences on the overall performance of the company include the customer's perspective (31%, financial perspective (29%, internal business processes (21%, learning, and growth 19%. Keywords: balance scorecard, paired comparison, coal transportation serviceABSTRAKPenelitian ini bertujuan untuk merancang pengukuran kinerja perusahaan dengan menggunakan pendekatan balance scorecard di industri jasa pengangkutan batu bara. Data kualitatif diperoleh melalui indepth interview digunakan untuk menentukan sasaran strategik, indikator kinerja utama, inisiatif strategi dan penanggungjawab setiap divisi setiap perspektif balance scorecard, sedangkan data kuantitatif digunakan untuk pembobotan melalui kuesioner dan dianalisis dengan menggunakan metode paired comparisson untuk mendapatkan perspektif yang paling berpengaruh terhadap kinerja perusahaan. Ukuran pencapaian kinerja perusahaan dari setiap KPI menggunakan; (1 scoring system dengan bantuan metode higher is better, lower is better dan precise is better;(2 traffic light system dengan menggunakan bantuan warna hijau, kuning, merah

  11. A New Approach to Design of Dependable Control Systems

    DEFF Research Database (Denmark)

    Blanke, M.; Jørgensen, R.B.; Svavarsson, M.

    1996-01-01

    This paper presents a new method for design of fault handling as a supervisory part of a control system.......This paper presents a new method for design of fault handling as a supervisory part of a control system....

  12. How can design approaches be integrated into entrepreneurship education?

    DEFF Research Database (Denmark)

    Færgemann, Helle Meibom; Nørgård, Rikke Toft; Robinson, Sarah

    analysed by scholars within both the design and entrepreneurship field to understand the potential of more fully integrating the design vocabulary and processes in entrepreneurship education. Results: Overall we see a lot of potential in integrating design elements into EE, if it is done with careful...

  13. Regional design : Discretionary approaches to regional planning in The Netherlands

    NARCIS (Netherlands)

    Balz, V.E.

    2017-01-01

    In recent decades, The Netherlands has seen an increase in the use of regional design-led practices in national indicative planning. Despite this, the interrelations between design and planning decision making are not well understood, and attempts to involve the expertise and ambition of designers

  14. User Participation: A New Approach to School Design in Korea

    Science.gov (United States)

    Rieh, Sun-Young; Kim, Jin-Wook; Yu, Woong-Sang

    2011-01-01

    The Korean Educational Development Institute (KEDI) has recently initiated a pilot project to develop a new prototype school, involving users in the design phase. This is the first time in Korea that users have been consulted on issues relating to school design. One of KEDI's objectives is to integrate specific elements into school design such as…

  15. Towards a User-Oriented Analytical Approach to Learning Design

    Science.gov (United States)

    San Diego, Jonathan P.; Laurillard, Diana; Boyle, Tom; Bradley, Claire; Ljubojevic, Dejan; Neumann, Tim; Pearce, Darren

    2008-01-01

    The London Pedagogy Planner (LPP) is a prototype for a collaborative online planning and design tool that supports lecturers in developing, analysing and sharing learning designs. The tool is based on a developing model of the components involved in learning design and the critical relationships between them. As a decision tool it makes the…

  16. Embedded Control System Design A Model Based Approach

    CERN Document Server

    Forrai, Alexandru

    2013-01-01

    Control system design is a challenging task for practicing engineers. It requires knowledge of different engineering fields, a good understanding of technical specifications and good communication skills. The current book introduces the reader into practical control system design, bridging  the gap between theory and practice.  The control design techniques presented in the book are all model based., considering the needs and possibilities of practicing engineers. Classical control design techniques are reviewed and methods are presented how to verify the robustness of the design. It is how the designed control algorithm can be implemented in real-time and tested, fulfilling different safety requirements. Good design practices and the systematic software development process are emphasized in the book according to the generic standard IEC61508. The book is mainly addressed to practicing control and embedded software engineers - working in research and development – as well as graduate students who are face...

  17. ADOBE ILLUSTRATOR AND GIMP - AN APPROACH TO GARMENT DESIGN

    Directory of Open Access Journals (Sweden)

    INDRIE Liliana

    2016-05-01

    Full Text Available Designing clothes has become easier with the use of clothing design software. One of the most popular and basic software made for garments design is Adobe Illustrator. It enables designers and small to medium businesses to create clothing designs with easy access to all assets, including images, colors, brushes, and type styles. While Illustrator has all the necessary elements and features that are ideal for creating designer clothing, GIMP provides basic set of tools for image editing. When used in combination with one another, these two programs provide just about all the tools an apparel designer needs to draw fashion design sketches, technical flat sketches, CAD presentations, graphic artworks, design embroideries etc. In this paper we show how to use the instruments of those two software in order to draw a woman jacket’s garments components and to fill with texture the jacket created. By utilizing Illustrator’s Symbol we created libraries of jacket components (puller zipper, label, then the brushes to design the zipper detail. Finally, by a drag and drop we added the zipper, the zipper puller and the label. GIMP gave us access to precise fabric textures which make our output so realistic that you can almost touch the fabric.

  18. Framing design research for service orientation through PSS approaches

    DEFF Research Database (Denmark)

    Sakao, Tomohiko; Sandström, Gunilla Ölundh; Matzen, Detlef

    2009-01-01

    In order to respond to the industrial trend towards service design and delivery, design research must address a vast area partially related to value creation, marketing and network theories. However, compared to the space to be explored, there is little insight available. Thus, this paper......, as a first step, proposes a way to frame such design research. First, an extensive literature review is performed of over 100 articles on not only PSS-design research but also on related research in fields as PSS in general, service design, innovation, and business models in a broad view. Based...... on the literature analysis, the authors present three crucial dimensions for service oriented design research, i.e. an offer dimension representing products and services, a provider dimension, and a customer/user dimension. In addition, three research targets are proposed; PSS-offer modelling, PSS development...

  19. I-Deals in Further Education? A New Approach to Managerial Job Design

    Science.gov (United States)

    Page, Damien

    2011-01-01

    This paper discusses the neglected theme of job design in education. It argues that the traditional top-down method of designing work roles ignores the interests, abilities and needs of employees and leads to individuals adopting an unsanctioned approach to job design, "job crafting". It is posited that a third approach is needed, that…

  20. Model-Based approaches to Human-Automation Systems Design

    DEFF Research Database (Denmark)

    Jamieson, Greg A.; Andersson, Jonas; Bisantz, Ann

    2012-01-01

    Human-automation interaction in complex systems is common, yet design for this interaction is often conducted without explicit consideration of the role of the human operator. Fortunately, there are a number of modeling frameworks proposed for supporting this design activity. However...... (and reportedly one or two critics) can engage one another on several agreed questions about such frameworks. The goal is to aid non-aligned practitioners in choosing between alternative frameworks for their human-automation interaction design challenges....

  1. Design of an Evolutionary Approach for Intrusion Detection

    Directory of Open Access Journals (Sweden)

    Gulshan Kumar

    2013-01-01

    ensemble methods like bagging and boosting. In addition, the proposed approach is a generalized classification approach that is applicable to the problem of any field having multiple conflicting objectives, and a dataset can be represented in the form of labelled instances in terms of its features.

  2. A Model of Human Variability in Viable Ship Design

    Science.gov (United States)

    2014-02-21

    unforeseen change or a novel situation can be incubated in the degrees of freedom afforded to an operator. These degrees of freedom allow for...team has been formed and how long they have interacted with relevant equipment; intactness may be conceptualized as binary or fuzzy (degrees or

  3. Designing Viable Republican Constitutions for Modern African States

    African Journals Online (AJOL)

    In this paper I argue for the adoption of an unmitigated republican constitutional system by modern African nation states as a necessary condition for the realisation of their democratic aspirations. I identify the continued retention of the traditional kingship institution, even in a much whittled down form, as a major impediment ...

  4. Designing Viable Republican Constitutions for Modern African States

    African Journals Online (AJOL)

    sulaiman.adebowale

    2008-04-09

    Apr 9, 2008 ... canism was an auspicious component of the rhetoric of anti-colonial liberation struggles in Africa, the reality in ..... As Alao puts it, on one hand, 'the opinion of the chiefs were heavily relied upon by the .... this role, traditional rulers can mobilise resources for public purposes, such as education, health, sport, ...

  5. Exploration and discovery: a nolinear approach to research by design

    Directory of Open Access Journals (Sweden)

    Rod Barnett

    2000-10-01

    Full Text Available Discover y-based research in landscape architecture requires design strategies that are open-ended and nonlinear, rather than research models that are focused on pre-determined outcomes or objectives. This should not mean a loss of rigour. A nonlinear model of landscape design is proposed, which adapts from scientific enquiry the distinction between the context of discovery and the context of justification. This model permits open-ended investigation by design, and provides a framework for peer review. It also provides a way for researchers to apply discovery based design to practical consultancy.

  6. Heritage Inquiries: A Designerly Approach to Human Values

    DEFF Research Database (Denmark)

    Giaccardi, Elisa; Iversen, Ole Sejer

    This two-day workshop brings together the interdisciplinary community of scholars and practitioners involved in the design of interactive systems and sharing a common interest in heritage matters. The workshop addresses heritage as a unique domain for the exploration of novel design inquiries...... into how we come together through separate understandings and attachments to artifacts, places, and events of the past as well as of the present. The aim of the workshop is to explore how design research in the heritage domain can contribute to human-centered interaction design, with a particular...

  7. Determining Wheel-Soil Interaction Loads Using a Meshfree Finite Element Approach Assisting Future Missions with Rover Wheel Design

    Science.gov (United States)

    Contreras, Michael T.; Peng, Chia-Yen; Wang, Dongdong; Chen, Jiun-Shyan

    2012-01-01

    A wheel experiencing sinkage and slippage events poses a high risk to rover missions as evidenced by recent mobility challenges on the Mars Exploration Rover (MER) project. Because several factors contribute to wheel sinkage and slippage conditions such as soil composition, large deformation soil behavior, wheel geometry, nonlinear contact forces, terrain irregularity, etc., there are significant benefits to modeling these events to a sufficient degree of complexity. For the purposes of modeling wheel sinkage and slippage at an engineering scale, meshfree finite element approaches enable simulations that capture sufficient detail of wheel-soil interaction while remaining computationally feasible. This study demonstrates some of the large deformation modeling capability of meshfree methods and the realistic solutions obtained by accounting for the soil material properties. A benchmark wheel-soil interaction problem is developed and analyzed using a specific class of meshfree methods called Reproducing Kernel Particle Method (RKPM). The benchmark problem is also analyzed using a commercially available finite element approach with Lagrangian meshing for comparison. RKPM results are comparable to classical pressure-sinkage terramechanics relationships proposed by Bekker-Wong. Pending experimental calibration by future work, the meshfree modeling technique will be a viable simulation tool for trade studies assisting rover wheel design.

  8. Roots of success: cultivating viable community forestry

    Energy Technology Data Exchange (ETDEWEB)

    MacQueen, Duncan

    2009-05-15

    Is community forestry emerging from the shadows? The evidence shows that locally controlled enterprises can be economically viable, and often build on stronger social and environmental foundations than the big private-sector players. Certainly this is an industry in need of a shakeup. Many forests have become flashpoints where agro-industry, large-scale logging concerns and conservation interests clash, while forest-dependent communities are left out in the cold. Meanwhile, governments – driven by concerns over the climate impacts of deforestation – are having to gear up for legal, sustainable forestry production. Community forestry could be crucial to solving many of these challenges. By building on local core capabilities and developing strategic partnerships, they are forging key new business models that could transform the sector.

  9. Inkjet printing of viable human dental follicle stem cells

    Directory of Open Access Journals (Sweden)

    Mau Robert

    2015-09-01

    Full Text Available Inkjet printing technology has the potential to be used for seeding of viable cells for tissue engineering approaches. For this reason, a piezoelectrically actuated, drop-on-demand inkjet printing system was applied to deliver viable human dental follicle stem cells (hDFSC of sizes of about 15 μm up to 20 μm in diameter. The purpose of these investigations was to verify the stability of the printing process and to evaluate cell viability post printing. Using a Nanoplotter 2.1 (Gesim, Germany equipped with the piezoelectric printhead NanoTip HV (Gesim, Germany, a concentration of 6.6 ×106 cells ml−1 in DMEM with 10% fetal calf serum (FCS could be dispensed. The piezoelectric printhead has a nominal droplet volume of ~ 400 pl and was set to a voltage of 75 V and a pulse of 50 μs while dosing 50 000 droplets over a time of 100 seconds. The volume and trajectory of the droplet were checked by a stroboscope test right before and after the printing process. It was found that the droplet volume decreases significantly by 35% during printing process, while the trajectory of the droplets remains stable with only an insignificant number of degrees deviation from the vertical line. It is highly probable that some cell sedimentations or agglomerations affect the printing performance. The cell viability post printing was assessed by using the Trypan Blue dye exclusion test. The printing process was found to have no significant influence on cell survival. In conclusion, drop-on-demand inkjet printing can be a potent tool for the seeding of viable cells.

  10. A New Design Approach to Game-Based Learning

    Science.gov (United States)

    Larsen, Lasse Juel

    2012-01-01

    This paper puts forward a new design perspective for game-based learning. The general idea is to abandon the long sought-after dream of designing a closed learning system, where students in both primary and secondary school could learn--without the interference of teachers--whatever subject they wanted while sitting in front of a computer. This…

  11. A practical approach to product design from a philosophical perspective

    NARCIS (Netherlands)

    Eggink, Wouter; Clarke, A.

    2008-01-01

    “Buy an identity or surprise your senses” are in short a few from the results of the course “Design for a specific Theme” by 4th grade students Industrial Design Engineering at Twente University. The theme in the title of this course is philosophical, based on the theory of globalization of German

  12. Contextualizing Secure Information System Design: A Socio-Technical Approach

    Science.gov (United States)

    Charif, Abdul Rahim

    2017-01-01

    Secure Information Systems (SIS) design paradigms have evolved in generations to adapt to IS security needs. However, modern IS are still vulnerable and are far from secure. The development of an underlying IS cannot be reduced to "technological fixes" neither is the design of SIS. Technical security cannot ensure IS security.…

  13. Reverse logistics network design: a holistic life cycle approach

    National Research Council Canada - National Science Library

    Daaboul, Joanna; Le Duigou, Julien; Penciuc, Diana; Eynard, Benoît

    2014-01-01

    .... This article addresses the issue of designing the reverse logistics network assuring the needed volume of recycled aluminum for the production of L-shaped front lower control arms for personal cars. It details the developed method and demonstrator for designing a reverse logistics network based on a life cycle assessment.

  14. The Use of an Experimental Design Approach to Investigate the ...

    African Journals Online (AJOL)

    NICO

    This study looked at using statistical design of experimental (DoE) principles to observe interactions between two graphite types and a nanocarbon ... Pb-acid battery, Pb-plate, graphite, expanders, design of experiment. 1. Introduction .... The CCA test was done by placing the cells in a freezer for 24 h at –18 ± 1 °C prior to ...

  15. Design of Nonlinear Circuits : The Linear Time-Varying Approach

    NARCIS (Netherlands)

    Kuijstermans, F.C.M.

    2003-01-01

    Over the last years the ever-growing demand for higher performance has led to much interest in using nonlinear circuit concepts for electronic circuit design. For this we have to deal with analysis and synthesis of dynamic nonlinear circuits. This thesis proposes to handle the nonlinear design

  16. A practical approach to teaching abstract product design issues

    NARCIS (Netherlands)

    Eggink, Wouter

    2009-01-01

    ‘Buy an identity’ and ‘surprise your senses’ are two of the ideas that were the outcome of a course ‘Design for a specific Theme’ (in the year 2006–07) held for 4th grade students of Industrial Design Engineering at Twente University. The theme in the title of this course was philosophical, based on

  17. Occupant safety design approaches using physical testing and numerical simulation.

    NARCIS (Netherlands)

    Linzmaier, L.C.; Carvalho, J.R.; Benar, M.; Vilela, D.; Altamore, P.

    2001-01-01

    The vehicle design environment from a crashworthiness and safety perspective has become increasingly complex in recent years. New legal requirements imposed by the European Union (EU) and the United States National Highway Traffic Safety Administration (NHTSA) have created a design space of great

  18. Understanding decision making in teachers’ curriculum design approaches

    NARCIS (Netherlands)

    Boschman, F.B.; McKenney, Susan; Voogt, Joke

    2014-01-01

    The goal of this study was to reach a better understanding of the intuitive decisions teachers make when designing a technology-rich learning environment. A multiple case-study design was employed to examine what kinds of factors (external priorities, existing orientations or practical concerns)

  19. Understanding decision making in teachers’ curriculum design approaches

    NARCIS (Netherlands)

    Boschman, Ferry; McKenney, Susan; Voogt, Joke

    2015-01-01

    The goal of this study was to reach a better understanding of the intuitive decisions teachers make when designing a technology-rich learning environment. A multiple case-study design was employed to examine what kinds of factors (external priorities, existing orientations or practical concerns)

  20. Understanding decision making in teachers' curriculum design approaches

    NARCIS (Netherlands)

    Boschman, F.; McKenney, S.; Voogt, J.M.

    2014-01-01

    The goal of this study was to reach a better understanding of the intuitive decisions teachers make when designing a technology-rich learning environment. A multiple case-study design was employed to examine what kinds of factors (external priorities, existing orientations or practical concerns)

  1. A different approach to designing visual displays and workstations

    Energy Technology Data Exchange (ETDEWEB)

    Brown-VanHoozer, S.A.

    1995-06-01

    The material presented in this paper is based on two studies involving the design of visual displays based on the user`s perspective model of a system. The studies involve a methodology known as Neuro-Linguistic Programming (NLP), and its use in expanding design choices from the user`s ``model of the world,`` and the use of virtual reality.

  2. Polymerase chain reaction-based discrimination of viable from non-viable Mycoplasma gallisepticum

    Directory of Open Access Journals (Sweden)

    Ching Giap Tan

    2014-02-01

    Full Text Available The present study was based on the reverse transcription polymerase chain reaction (RT-PCR of the 16S ribosomal nucleic acid (rRNA of Mycoplasma for detection of viable Mycoplasma gallisepticum. To determine the stability of M. gallisepticum 16S rRNA in vitro, three inactivation methods were used and the suspensions were stored at different temperatures. The 16S rRNA of M. gallisepticum was detected up to approximately 20–25 h at 37 °C, 22–25 h at 16 °C, and 23–27 h at 4 °C. The test, therefore, could detect viable or recently dead M. gallisepticum (< 20 h. The RT-PCR method was applied during an in vivo study of drug efficacy under experimental conditions, where commercial broiler-breeder eggs were inoculated with M. gallisepticum into the yolk. Hatched chicks that had been inoculated in ovo were treated with Macrolide 1. The method was then applied in a flock of day 0 chicks with naturally acquired vertical transmission of M. gallisepticum, treated with Macrolide 2. Swabs of the respiratory tract were obtained for PCR and RT-PCR evaluations to determine the viability of M. gallisepticum. This study proved that the combination of both PCR and RT-PCR enables detection and differentiation of viable from non-viable M. gallisepticum.

  3. DESIGN AS GENERATOR (DAG: AN ARCHITECTURAL APPROACH FOR EMPOWERING COMMUNITY

    Directory of Open Access Journals (Sweden)

    KATOPPO Martin

    2014-12-01

    Full Text Available Design as we imagine should act like a generator, to become light for others. This is the concept of Design as Generator (DAG. It main goal is for bring the essence of Architecture in which to enhance the quality of life not just for self but for others. For this purpose we create D-Apps (Dwelling Applications, D-PaD and A-PaD (Dwelling and Area Prototype Applicative Design that will explained by our experimental dwelling project 200 Rumah Besi and our future project taki (taman kita Community Sustainable Park. We also developed DAG particular empowering and participatory design methodology – inspired by PAR (Participatory Action Research and DT (Design Thinking through mixed methods research, the Sequential Embedded Experimental Model.

  4. Coach design for the Korean high-speed train: a systematic approach to passenger seat design and layout.

    Science.gov (United States)

    Jung, E S; Han, S H; Jung, M; Choe, J

    1998-12-01

    Proper ergonomic design of a passenger seat and coach layout for a high-speed train is an essential component that is directly related to passenger comfort. In this research, a systematic approach to the design of passenger seats was described and the coach layout which reflected the tradeoff between transportation capacity and passenger comfort was investigated for the Korean high-speed train. As a result, design recommendations and specifications of the passenger seat and its layout were suggested. The whole design process is composed of four stages. A survey and analysis of design requirement was first conducted, which formed the base for designing the first and second class passenger seats. Prototypes were made and evaluated iteratively, and seat arrangement and coach layout were finally obtained. The systematic approach and recommendations suggested in this study are expected to be applicable to the seat design for public transportations and to help modify and redesign existing vehicular seats.

  5. A Combined Approach for Component-based Software Design

    NARCIS (Netherlands)

    Guareis de farias, Cléver; van Sinderen, Marten J.; Ferreira Pires, Luis; Quartel, Dick; Baldoni, R.

    2001-01-01

    Component-based software development enables the construction of software artefacts by assembling binary units of production, distribution and deployment, the so-called software components. Several approaches addressing component-based development have been proposed recently. Most of these

  6. Systems Approaches to Understanding and Designing Allosteric Proteins.

    Science.gov (United States)

    Raman, Srivatsan

    2018-01-08

    The study of allostery has a central place in biology because of the myriad roles of allosteric proteins in cellular function. As technologies for probing the spatiotemporal resolution of biomolecules have become increasingly sophisticated, so has our understanding of the diverse structural and molecular mechanisms of allosteric proteins. Studies have shown that the allosteric signal is transmitted a through a network of residue-residue interactions connecting distal sites on a protein. Linking structural and dynamical changes to the functional role of individual residues will give a more complete molecular view of allostery. In this work, we highlight new mutational technologies that enable a systems-level, quantitative description of allostery that dissect the role of individual residues through large-scale functional screens. A molecular model for predicting allosteric hot spots can be developed by applying statistical tools on the resulting large sequence-structure-function data sets. Design of allosteric proteins with new function is essential for engineering biological systems. Previous design efforts demonstrate that the allosteric network is a powerful functional constraint in the design of novel or enhanced allosteric proteins. We discuss how a priori knowledge of an allosteric network could improve rational design by facilitating better navigation of the design space. Understanding the molecular "rules" governing allostery would elucidate the molecular basis of dysfunction in disease-associated allosteric proteins, provide a means for designing tailored therapeutics, and enable the design of new sensors and enzymes for synthetic biology.

  7. Designing Wearable Personal Assistants for Surgeons: An Egocentric Approach

    DEFF Research Database (Denmark)

    Jalaliniya, Shahram; Pederson, Thomas

    2015-01-01

    The design of general-purpose wearable computers demands particular care for how human perception, cognition, and action work and work together. The authors propose a human body-and-mind centric (egocentric as opposed to device-centric) design framework and present initial findings from deploying...... it in the design of a wearable personal assistant (WPA) for orthopedic surgeons. The result is a Google Glass-based prototype system aimed at facilitating touchless interaction with x-ray images, browsing of electronic patient records (EPR) when on the move, and synchronized ad hoc remote collaboration....... This article is part of a special issue on digitally enhanced reality....

  8. Optical approach to design a beam-down heliostats plant

    Science.gov (United States)

    Fontani, Daniela; Sansoni, Paola; Francini, Franco; Jafrancesco, David

    2017-06-01

    The optical design development of beam-down heliostat fields is complex and timewasting. It requires the use of an optical design software package in order to evaluate the interactions between light and surfaces and the solar divergence effects. This paper proposes a three-step procedure devoted to design a beam-down heliostat field taking into account the actual technical constraints; in particular, the shaping of the field starts from the request to have a sufficient uniformity irradiance on the internal surfaces of the receiver. The procedure is applied to an effective field simulation in order to allow a better understanding of its different phases.

  9. Cognitive System Engineering Approach to Design of Work Support Systems

    DEFF Research Database (Denmark)

    Rasmussen, Jens

    1995-01-01

    The problem of designing work support systems for flexible, dynamic work environments is discussed and a framework for analysis of work in terms of behavior shaping constraints is described. The application of 'ecological interfaces' presenting to the user a map of the relational structure...... of the work space is advocated from the thesis that a map is a better guidance of discretionary tasks than is a route instruction. For the same reason, support of system design is proposed in terms of maps of the design territory, rather than in terms of guidelines....

  10. Issues associated with a total systems approach to designing dependable systems

    Energy Technology Data Exchange (ETDEWEB)

    Chisholm, G.H.

    1995-12-31

    A total system approach, developed by the nuclear-reactor-safety community, is extrapolated to the design of complex, critical systems. The essential properties of these systems are described, and a generic paradigm for subsequent designs is proposed.

  11. A dynamic approach to real-time performance measurement in design projects

    DEFF Research Database (Denmark)

    Skec, Stanko; Cash, Philip; Storga, Mario

    2017-01-01

    and teamwork performance in engineering design projects. This integrates multiple, previously disparate, aspects of design management and performance measurement theory in a single framework. Further, a fully realised performance measurement approach is developed, which complements existing management...

  12. Food product design. An integrated approach (2nd edition completely revised)

    NARCIS (Netherlands)

    Linnemann, A.R.; Schroën, C.G.P.H.; Boekel, van M.A.J.S.

    2011-01-01

    'Food product design ­ An integrated approach' deals with food product design from a technological perspective. It presents creative techniques for the innovation process and structured methodologies to translate consumer wishes into product properties based on Quality Function Deployment.

  13. Virtual Reality as Innovative Approach to the Interior Designing

    National Research Council Canada - National Science Library

    Pavol Kaleja; Mária Kozlovská

    2017-01-01

    ...). A group of real-time visualization, supported by hardware tools like Oculus Rift HTC Vive, provides free walkthrough and movement in virtual interior with the possibility of virtual designing...

  14. A methodological approach to designing sewer system control

    DEFF Research Database (Denmark)

    Mollerup, Ane Loft

    When designing sewer system control, there is a lack of methodology and tools that can aid in the design process. In 2004 the PASST1 framework was presented that focuses on determining the potential for control in sewer sys-tem operation. However, for the actual design of control systems urban......, 2) the coordinating control layer, 3) the optimisation layer and 4) the management of objectives layer. The time-scale dependent hierarchy for sewer system control is put into a framework that also contains a terminology related to control. In this way the1 Planning aid for sewer system real time...... sewer system control was proposed and followed. The individual layers of the hierarchy were designed one by one for a case study in Copenhagen, with the methods and tools taken from both clas-sical and modern control theory. The tools of classical control theory are developed for systems that can...

  15. Enhanced project brief: Structured approach to client-designer interface

    OpenAIRE

    Khosrowshahi, F

    2015-01-01

    © Emerald Group Publishing Limited. Purpose - The focus of this work is on the client-designer interface where decisions have significant impact over the lifecycle of the project. Therefore, the briefing stage is examined in the context of clients needs which is divided into project-based strategy and broader clients strategy. The purpose of this paper is to address the pitfalls in the briefing process which has been attributed to the shortcomings in the client-designer communication interfac...

  16. Traditional Approach towards Contemporary Design: A Case Study

    OpenAIRE

    Sushama S. Dhepe; Dr. Sheeba Valsson

    2017-01-01

    Traditional architecture acts as a valuable source of inspiration for contemporary designs. The paper aims to analyse the link established between contemporary architecture that with the traditional architecture; as architecture and time are considered as two variables. The study investigates how traditional architecture has been integrated and manifested in contemporary architecture. The paper examines a contemporary house based on traditional design and a view into the past era. The attempt...

  17. In Silico Approach towards Designing Virtual Oligopeptides for HRSV

    OpenAIRE

    Jain, Ruchi; Piramanayagam, Shanmughavel

    2014-01-01

    HRSV (human respiratory syncytial virus) is a serious cause of lower respiratory tract illness in infants and young children. Designing inhibitors from the proteins involved in virus replication and infection process provides target for new therapeutic treatments. In the present study, in silico docking was performed using motavizumab as a template to design motavizumab derived oligopeptides for developing novel anti-HRSV agents. Additional simulations were conducted to study the conformation...

  18. Virtual Reality as Innovative Approach to the Interior Designing

    OpenAIRE

    Kaleja Pavol; Kozlovská Mária

    2017-01-01

    We can observe significant potential of information and communication technologies (ICT) in interior designing field, by development of software and hardware virtual reality tools. Using ICT tools offer realistic perception of proposal in its initial idea (the study). A group of real-time visualization, supported by hardware tools like Oculus Rift HTC Vive, provides free walkthrough and movement in virtual interior with the possibility of virtual designing. By improving of ICT software tools ...

  19. A New Approach in CAD System for Designing Shoes

    OpenAIRE

    Guid, Nikola; Kolmanič, Simon

    2003-01-01

    The flattening of digitized surfaces is still very important in design of thin walled objects such as the airplane wings, parts of car bodies, textile products, and shoe uppers. Especially in shoe industry, the ability of quick respond to changing market needs is essential for successful competition. To give needed flexibility to a shoe designer, special CAD/CAM systems have been developed. Those systems are based on algorithms for surface reconstruction and surface flattening. In this articl...

  20. GreenTeam. A new educative approach to sustainable design

    OpenAIRE

    Di Salvo, Andrea; Barbero, Silvia; Gaiardo, Andrea; Rivella, Giada

    2017-01-01

    Sustainability, meaning its three pillars, social, economic and environmental, is by now a prerequisite in the design phase and one of the mandatory topics in educational programs, both for future designers and other professions. This happens even more if the project theme concerns mobility or waste management, fields in which daily behaviours impact on the system, the ones adopted by teenagers as well. Is it possible and correct to use an academic teaching methodology, based on participation...

  1. Robust design of biological circuits: evolutionary systems biology approach.

    Science.gov (United States)

    Chen, Bor-Sen; Hsu, Chih-Yuan; Liou, Jing-Jia

    2011-01-01

    Artificial gene circuits have been proposed to be embedded into microbial cells that function as switches, timers, oscillators, and the Boolean logic gates. Building more complex systems from these basic gene circuit components is one key advance for biologic circuit design and synthetic biology. However, the behavior of bioengineered gene circuits remains unstable and uncertain. In this study, a nonlinear stochastic system is proposed to model the biological systems with intrinsic parameter fluctuations and environmental molecular noise from the cellular context in the host cell. Based on evolutionary systems biology algorithm, the design parameters of target gene circuits can evolve to specific values in order to robustly track a desired biologic function in spite of intrinsic and environmental noise. The fitness function is selected to be inversely proportional to the tracking error so that the evolutionary biological circuit can achieve the optimal tracking mimicking the evolutionary process of a gene circuit. Finally, several design examples are given in silico with the Monte Carlo simulation to illustrate the design procedure and to confirm the robust performance of the proposed design method. The result shows that the designed gene circuits can robustly track desired behaviors with minimal errors even with nontrivial intrinsic and external noise.

  2. Moving Aerospace Structural Design Practice to a Load and Resistance Factor Approach

    Science.gov (United States)

    Larsen, Curtis E.; Raju, Ivatury S.

    2016-01-01

    Aerospace structures are traditionally designed using the factor of safety (FOS) approach. The limit load on the structure is determined and the structure is then designed for FOS times the limit load - the ultimate load. Probabilistic approaches utilize distributions for loads and strengths. Failures are predicted to occur in the region of intersection of the two distributions. The load and resistance factor design (LRFD) approach judiciously combines these two approaches by intensive calibration studies on loads and strength to result in structures that are efficient and reliable. This paper discusses these three approaches.

  3. A Course on Serious Game Design and Development Using an Online Problem-Based Learning Approach

    Science.gov (United States)

    Kapralos, Bill; Fisher, Stephanie; Clarkson, Jessica; van Oostveen, Roland

    2015-01-01

    Purpose: The purpose of this paper is to describe a novel undergraduate course on serious game design and development that integrates both game and instructional design, thus providing an effective approach to teaching serious game design and development. Very little effort has been dedicated to the teaching of proper serious game design and…

  4. The effects of a web-based training in an instructionals systems design approach on teacher's instructional design behavior

    NARCIS (Netherlands)

    Hoogveld, Bert; Paas, Fred; Jochems, Wim; Van Merriënboer, Jeroen

    2010-01-01

    Hoogveld, A. W. M., Paas, F., Jochems, W. M. G., & Van Merriënboer, J. J. G. (2001). The effects of a web-based training in an instructionals systems design approach on teacher's instructional design behavior. Computers in human behavior, 17, 363-371.

  5. Rural eHealth nutrition education for limited-income families: an iterative and user-centered design approach.

    Science.gov (United States)

    Atkinson, Nancy L; Saperstein, Sandra L; Desmond, Sharon M; Gold, Robert S; Billing, Amy S; Tian, Jing

    2009-06-22

    Adult women living in rural areas have high rates of obesity. Although rural populations have been deemed hard to reach, Internet-based programming is becoming a viable strategy as rural Internet access increases. However, when people are able to get online, they may not find information designed for them and their needs, especially harder to reach populations. This results in a "content gap" for many users. User-centered design is a methodology that can be used to create appropriate online materials. This research was conducted to apply a user-centered approach to the design and development of a health promotion website for low-income mothers living in rural Maryland. Three iterative rounds of concept testing were conducted to (1) identify the name and content needs of the site and assess concerns about registering on a health-related website; (2) determine the tone and look of the website and confirm content and functionality; and (3) determine usability and acceptability. The first two rounds involved focus group and small group discussions, and the third round involved usability testing with individual women as they used the prototype system. The formative research revealed that women with limited incomes were enthusiastic about a website providing nutrition and physical activity information targeted to their incomes and tailored to their personal goals and needs. Other priority content areas identified were budgeting, local resources and information, and content that could be used with their children. Women were able to use the prototype system effectively. This research demonstrated that user-centered design strategies can help close the "content gap" for at-risk audiences.

  6. Modelling the role of the design context in the design process: a domain-independent approach

    OpenAIRE

    Reymen, Isabelle; Kroes, P.; Basten, T.; Durling, D.; Shackleton, J

    2002-01-01

    Domain-independent models of the design process are an important means for facilitating interdisciplinary communication and for supporting multidisciplinary design. Many so-called domain-independent models are, however, not really domain independent. We state that, to be domain independent, the models must abstract from domain-specific aspects, be based on the study of several design disciplines, and be useful for many design disciplines and for multidisciplinary design teams. This paper desc...

  7. The Conceptual Mechanism for Viable Organizational Learning Based on Complex System Theory and the Viable System Model

    Science.gov (United States)

    Sung, Dia; You, Yeongmahn; Song, Ji Hoon

    2008-01-01

    The purpose of this research is to explore the possibility of viable learning organizations based on identifying viable organizational learning mechanisms. Two theoretical foundations, complex system theory and viable system theory, have been integrated to provide the rationale for building the sustainable organizational learning mechanism. The…

  8. An automated approach to the design of decision tree classifiers

    Science.gov (United States)

    Argentiero, P.; Chin, R.; Beaudet, P.

    1982-01-01

    An automated technique is presented for designing effective decision tree classifiers predicated only on a priori class statistics. The procedure relies on linear feature extractions and Bayes table look-up decision rules. Associated error matrices are computed and utilized to provide an optimal design of the decision tree at each so-called 'node'. A by-product of this procedure is a simple algorithm for computing the global probability of correct classification assuming the statistical independence of the decision rules. Attention is given to a more precise definition of decision tree classification, the mathematical details on the technique for automated decision tree design, and an example of a simple application of the procedure using class statistics acquired from an actual Landsat scene.

  9. Entropy Minimization Design Approach of Supersonic Internal Passages

    Directory of Open Access Journals (Sweden)

    Jorge Sousa

    2015-08-01

    Full Text Available Fluid machinery operating in the supersonic regime unveil avenues towards more compact technology. However, internal supersonic flows are associated with high aerodynamic and thermal penalties, which usually prevent their practical implementation. Indeed, both shock losses and the limited operational range represent particular challenges to aerodynamic designers that should be taken into account at the initial phase of the design process. This paper presents a design methodology for supersonic passages based on direct evaluations of the velocity field using the method of characteristics and computation of entropy generation across shock waves. This meshless function evaluation tool is then coupled to an optimization scheme, based on evolutionary algorithms that minimize the entropy generation across the supersonic passage. Finally, we assessed the results with 3D Reynolds Averaged Navier Stokes calculations.

  10. Antenna Design Concepts Based on Transformation Electromagnetics Approach

    Directory of Open Access Journals (Sweden)

    P.-H. Tichit

    2012-12-01

    Full Text Available Using the idea of wave manipulation via coordinate transformation, we demonstrate the design of novel antenna concepts. The manipulation is enabled by composite metamaterials that realize the space coordinate transformation. We present the design, realization and characterization of three types of antennas: a directive, a steered beam and a quasi-isotropic one. Numerical simulations together with experimental measurements are performed in order to validate the concept. Near-field cartography and far-field pattern measurements performed on a fabricated prototype agree qualitatively with Finite Element Method (FEM simulations. It is shown that a particular radiation can be transformed at ease into a desired one by modifying the electromagnetic properties of the space around it. This idea can find various applications in novel antenna design techniques for aeronautical, telecommunication and transport domains.

  11. Computer aided fixture design - A case based approach

    Science.gov (United States)

    Tanji, Shekhar; Raiker, Saiesh; Mathew, Arun Tom

    2017-11-01

    Automated fixture design plays important role in process planning and integration of CAD and CAM. An automated fixture setup design system is developed where when fixturing surfaces and points are described allowing modular fixture components to get automatically select for generating fixture units and placed into position with satisfying assembled conditions. In past, various knowledge based system have been developed to implement CAFD in practice. In this paper, to obtain an acceptable automated machining fixture design, a case-based reasoning method with developed retrieval system is proposed. Visual Basic (VB) programming language is used in integrating with SolidWorks API (Application programming interface) module for better retrieval procedure reducing computational time. These properties are incorporated in numerical simulation to determine the best fit for practical use.

  12. In Silico Approach towards Designing Virtual Oligopeptides for HRSV

    Directory of Open Access Journals (Sweden)

    Ruchi Jain

    2014-01-01

    Full Text Available HRSV (human respiratory syncytial virus is a serious cause of lower respiratory tract illness in infants and young children. Designing inhibitors from the proteins involved in virus replication and infection process provides target for new therapeutic treatments. In the present study, in silico docking was performed using motavizumab as a template to design motavizumab derived oligopeptides for developing novel anti-HRSV agents. Additional simulations were conducted to study the conformational propensities of the oligopeptides and confirmed the hypothesis that the designed oligopeptide is highly flexible and capable of assuming stable confirmation. Our study demonstrated the best specific interaction of GEKKLVEAPKS oligopeptide for glycoprotein strain A among various screened oligopeptides. Encouraged by the results, we expect that the proposed scheme will provide rational choices for antibody reengineering which is useful for systematically identifying the possible ways to improve efficacy of existing antibody drugs.

  13. Tunable photonic filters: a digital signal processing design approach.

    Science.gov (United States)

    Binh, Le Nguyen

    2009-05-20

    Digital signal processing techniques are used for synthesizing tunable optical filters with variable bandwidth and centered reference frequency including the tunability of the low-pass, high-pass, bandpass, and bandstop optical filters. Potential applications of such filters are discussed, and the design techniques and properties of recursive digital filters are outlined. The basic filter structures, namely, the first-order all-pole optical filter (FOAPOF) and the first-order all-zero optical filter (FOAZOF), are described, and finally the design process of tunable optical filters and the designs of the second-order Butterworth low-pass, high-pass, bandpass, and bandstop tunable optical filters are presented. Indeed, we identify that the all-zero and all-pole networks are equivalent with well known principles of optics of interference and resonance, respectively. It is thus very straightforward to implement tunable optical filters, which is a unique feature.

  14. A New Design Approach to Game-Based learning

    DEFF Research Database (Denmark)

    Larsen, Lasse Juel

    2012-01-01

    This paper puts forward a new design perspective for gamebased learning. The general idea is to abandon the long sought-after dream of designing a closed learning system, where students in both primary and secondary school could learn – without the interference of teachers – whatever subject...... collision course with off-the-shelf, commercial entertainment games. This paper promotes two different yet interconnected ideas. The first aims to describe a new design perspective for game-based learning, which in many ways not only will provoke the abovementioned latent dream of a closed game...... learner from primary to secondary school. He or she is often unable to fully grasp, understand or comprehend the learning process in which he or she is embedded. Portfolios, and especially e-portfolios, can be used to encourage reflection on both the learner’s development and the learning process in order...

  15. Rural eHealth Nutrition Education for Limited-Income Families: An Iterative and User-Centered Design Approach

    OpenAIRE

    Atkinson, Nancy L; Saperstein, Sandra L.; Desmond, Sharon M; Gold, Robert S.; Billing, Amy S; Tian, Jing

    2009-01-01

    Background Adult women living in rural areas have high rates of obesity. Although rural populations have been deemed hard to reach, Internet-based programming is becoming a viable strategy as rural Internet access increases. However, when people are able to get online, they may not find information designed for them and their needs, especially harder to reach populations. This results in a ?content gap? for many users. Objective User-centered design is a methodology that can be used to create...

  16. Approach to novel design of CO2 based centrifugal compressor

    Directory of Open Access Journals (Sweden)

    Kura Tomasz

    2016-01-01

    Full Text Available Even though turbomachinery design issues have been investigated almost since the beginning of engineering, its optimization process is still important. With the development of refrigeration devices and ORC based distributed generation facilities, a need for efficient and low-energy compressors and turbines became even more demanding. Such machines working with typical fluid, like air, are well described, but there is a room regarding the fluids like CO2, vapour of organic fluids, etc. The main objective of present studies is to propose a numerical model of the centrifugal compressor, with CO2 as the working fluid. Such unit may be a part of refrigeration cycle. Commonly, the scroll or piston compressors are used in such cases, however some discussed disadvantages show that the novel designs should be looked for. Properly designed centrifugal compressors can have higher efficiency than the presently used. Three dimensional analyses of proposed geometries were conducted – using a model including heat, mass and momentum conservation laws as well as ideal gas law. Verification of the proposed mesh and results was performed in the basis of values obtained using theoretical and empirical equations. With about 700 000 control volumes in the validated model, error of the results was no higher than 5%, with only about 1% in regards to the thermal parameters. Two design proposals were analysed, with performance maps as the main comparison factor. Apart from performance characteristics, the pressure and velocity fields were presented, showing the process of flow structure optimization. The main goal was to reduce negative effects of pressure and velocity gradients on the performance. Proposed precursory design might be a good starting point for further development of compressors. The results of numerical analysis were promising and shows the possibility of proposed design usage in practical applications, however to obtain deep understanding of the

  17. Treatment noncompliance in randomized experiments: statistical approaches and design issues.

    Science.gov (United States)

    Sagarin, Brad J; West, Stephen G; Ratnikov, Alexander; Homan, William K; Ritchie, Timothy D; Hansen, Edward J

    2014-09-01

    Treatment noncompliance in randomized experiments threatens the validity of causal inference and the interpretability of treatment effects. This article provides a nontechnical review of 7 approaches: 3 traditional and 4 newer statistical analysis strategies. Traditional approaches include (a) intention-to-treat analysis (which estimates the effects of treatment assignment irrespective of treatment received), (b) as-treated analysis (which reassigns participants to groups reflecting the treatment they actually received), and (c) per-protocol analysis (which drops participants who did not comply with their assigned treatment). Newer approaches include (d) the complier average causal effect (which estimates the effect of treatment on the subpopulation of those who would comply with their assigned treatment), (e) dose-response estimation (which uses degree of compliance to stratify participants, producing an estimate of a dose-response relationship), (f) propensity score analysis (which uses covariates to estimate the probability that individual participants will comply, enabling estimates of treatment effects at different propensities), and (g) treatment effect bounding (which calculates a range of possible treatment effects applicable to both compliers and noncompliers). The discussion considers the areas of application, the quantity estimated, the underlying assumptions, and the strengths and weaknesses of each approach. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  18. Design of multimodal transport networks : A hierarchical approach

    NARCIS (Netherlands)

    Van Nes, R.

    2002-01-01

    Multimodal transport, that is using two or more transport modes for a trip between which a transfer is necessary, seems an interesting approach to solving today's transportation problems with respect to the deteriorating accessibility of city centres, recurrent congestion, and environmental impact.

  19. A hybrid approach to designing inbound-resupply strategies

    NARCIS (Netherlands)

    Dullaert, Wout; Vernimmen, Bert; Raa, Birger; Witlox, Frank

    A new hybrid approach was developed to determine the optimal inbound-resupply strategy when suppliers ship goods to receivers. The optimal reorder level was calculated on the basis of a simulation of the distribution of demand and the lead time of the various sourcing alternatives. An evolutionary

  20. Designing renewable energy systems a life cycle assessment approach

    CERN Document Server

    Gerber, Leda

    2014-01-01

    The book discusses a multi-objective optimization approach in LCA that allows the flexible construction of comprehensive Pareto fronts to help understand the weightings and relative importance of its elements. The methodology is applied to the pertinent topics of thermochemical wood conversion, deep geothermal energy, and regional energy planning.

  1. Applied approach slab settlement research, design/construction : final report.

    Science.gov (United States)

    2013-08-01

    Approach embankment settlement is a pervasive problem in Oklahoma and many other states. The bump and/or abrupt slope change poses a danger to traffic and can cause increased dynamic loads on the bridge. Frequent and costly maintenance may be needed ...

  2. Blended Learning in Higher Education: Three Different Design Approaches

    Science.gov (United States)

    Alammary, Ali; Sheard, Judy; Carbone, Angela

    2014-01-01

    Blended learning has been growing in popularity as it has proved to be an effective approach for accommodating an increasingly diverse student population whilst adding value to the learning environment through incorporation of online teaching resources. Despite this growing interest, there is ongoing debate about the definition of the concept of…

  3. Combined electronic structure and evolutionary search approach to materials design

    DEFF Research Database (Denmark)

    Johannesson, Gisli Holmar; Bligaard, Thomas; Ruban, Andrei

    2002-01-01

    We show that density functional theory calculations have reached an accuracy and speed making it possible to use them in conjunction with an evolutionary algorithm to search for materials with specific properties. The approach is illustrated by finding the most stable four component alloys out of...

  4. A combined approach of complex eigenvalue analysis and design of ...

    African Journals Online (AJOL)

    This paper proposes an approach to investigate the influencing factors of the brake pad on the disc brake squeal by integrating finite element simulations with statistical regression techniques. Complex eigenvalue analysis (CEA) has been widely used to predict unstable frequencies in brake systems models. The finite ...

  5. Deletion of ultraconserved elements yields viable mice

    Energy Technology Data Exchange (ETDEWEB)

    Ahituv, Nadav; Zhu, Yiwen; Visel, Axel; Holt, Amy; Afzal, Veena; Pennacchio, Len A.; Rubin, Edward M.

    2007-07-15

    Ultraconserved elements have been suggested to retainextended perfect sequence identity between the human, mouse, and ratgenomes due to essential functional properties. To investigate thenecessities of these elements in vivo, we removed four non-codingultraconserved elements (ranging in length from 222 to 731 base pairs)from the mouse genome. To maximize the likelihood of observing aphenotype, we chose to delete elements that function as enhancers in amouse transgenic assay and that are near genes that exhibit markedphenotypes both when completely inactivated in the mouse as well as whentheir expression is altered due to other genomic modifications.Remarkably, all four resulting lines of mice lacking these ultraconservedelements were viable and fertile, and failed to reveal any criticalabnormalities when assayed for a variety of phenotypes including growth,longevity, pathology and metabolism. In addition more targeted screens,informed by the abnormalities observed in mice where genes in proximityto the investigated elements had been altered, also failed to revealnotable abnormalities. These results, while not inclusive of all thepossible phenotypic impact of the deleted sequences, indicate thatextreme sequence constraint does not necessarily reflect crucialfunctions required for viability.

  6. Is Greenberg's "Macro-Carib" viable?

    Directory of Open Access Journals (Sweden)

    Spike Gildea

    Full Text Available In his landmark work Language in the Americas, Greenberg (1987 proposed that Macro-Carib was one of the major low-level stocks of South America, which together with Macro-Panoan and Macro-Ge-Bororo were claimed to comprise the putative Ge-Pano-Carib Phylum. His Macro-Carib includes the isolates Andoke and Kukura, and the Witotoan, Peba-Yaguan, and Cariban families. Greenberg's primary evidence came from person-marking paradigms in individual languages, plus scattered words from individual languages collected into 79 Macro-Carib 'etymologies' and another 64 Amerind 'etymologies'. The goal of this paper is to re-evaluate Greenberg's Macro-Carib claim in the light of the much more extensive and reliable language data that has become available largely since 1987. Based on full person-marking paradigms for Proto-Cariban, Yagua, Bora and Andoke, we conclude that Greenberg's morphological claims are unfounded. For our lexical comparison, we created lexical lists for Proto-Cariban, Proto-Witotoan, Yagua and Andoke, for both Greenberg's 143 putative etymologies and for the Swadesh 100 list. From both lists, a total of 23 potential cognates were found, but no consonantal correspondences were repeated even once. We conclude that our greatly expanded and improved database does not provide sufficient evidence to convince the skeptic that the Macro-Carib hypothesis is viable

  7. Space Station Freedom - Approaching the critical design phase

    Science.gov (United States)

    Kohrs, Richard H.; Huckins, Earle, III

    1992-01-01

    The status and future developments of the Space Station Freedom are discussed. To date detailed design drawings are being produced to manufacture SSF hardware. A critical design review (CDR) for the man-tended capability configuration is planned to be performed in 1993 under the SSF program. The main objective of the CDR is to enable the program to make a full commitment to proceed to manufacture parts and assemblies. NASA recently signed a contract with the Russian space company, NPO Energia, to evaluate potential applications of various Russian space hardware for on-going NASA programs.

  8. A New Approach of Designing Superalloys for Low Density

    Science.gov (United States)

    MacKay, Rebecca A.; Gabb, Timothy P.; Smialek, James L.; Nathal, Michael V.

    2010-01-01

    New low-density single-crystal (LDS) alloy, have bee. developed for turbine blade applications, which have the potential for significant improvements in the thrust-to-weight ratio over current production superalloys. An innovative alloying strategy was wed to achieve alloy density reductions, high-temperature creep resistance, microstructural stability, and cyclic oxidation resistance. The alloy design relies on molybdenum as a potent. lower-density solid-solution strengthener in the nickel-based superalloy. Low alloy density was also achieved with modest rhenium levels tmd the absence of tungsten. Microstructural, physical mechanical, and environmental testing demonstrated the feasibility of this new LDS superalloy design.

  9. A new approach of designing superalloys for low density

    Science.gov (United States)

    Mackay, R. A.; Gabb, T. P.; Smialek, J. L.; Nathal, M. V.

    2010-01-01

    New low-density single-crystal (IDS) alloys have been developed for turbine blade applications, which have the potential for significant improvements in the thrust-to-weight ratio over current production superalloys. An innovative alloying strategy was used to achieve alloy density reductions, high-temperature creep resistance, micro-structural stability, and cyclic oxidation resistance. The alloy design relies on molybdenum as a potent, lower-density solid-solution strengthener in the nickel-based superalloy. Low alloy density was also achieved with modest rhenium levels and the absence of tungsten. Microstructural, physical, mechanical, and environmental testing demonstrated the feasibility of this new IDS superalloy design.

  10. An Academic Integrity Approach to Learning and Assessment Design

    Science.gov (United States)

    Hamilton, Margaret; Richardson, Joan

    2007-01-01

    In this paper, we discuss the role of the educator in terms of designing a learning environment for the student which encourages the student to develop their own academic integrity. In such an environment, there is no need for the student to resort to plagiarism, as the learning and assessment tasks are not conducive to cheating, being unique and…

  11. Thermoplastic Composite Wind Turbine Blades : An Integrated Design Approach

    NARCIS (Netherlands)

    Joncas, S.

    2010-01-01

    This thesis proposes a new structural design concept for future large wind turbine blades based on fully recyclable thermoplastic composites (TPC). With respect to material properties, cost and processing, reactively processed anionic polyamide-6 (APA-6) has been identified as the most promising

  12. Systems Engineering Approach for Conceptual Design of Frigate

    Science.gov (United States)

    2015-09-01

    Requirement √ 25 Shielding /Ground Planes i) EMI/ EMC Shielding and Isolation Purposes √ 26 Compartment i) Requirement of Blast-Off...System DOD Department of Defense DOE Design of Experiments EEZ Exclusive Economic Zone EM Electromagnetic xiv EMI/ EMC Electromagnetic...Electromagnetic interference/electromagnetic compatibility (EMI/ EMC ) trial 8. Sea Acceptance Test (SAT) 9. Live Firing Test (LFT), if part of the

  13. Experiments in serious game design : a cognitive approach

    NARCIS (Netherlands)

    van der Spek, E.D.

    2011-01-01

    Serious games sometimes are not as efficacious as they should be when it comes to learning, but the reasons for this are unclear; something that is brought on by a lack of rigorous scientific research into what constitutes good game design. We created a serious game with which players can learn the

  14. Communicative Syllabus Design--The Topic and Task Approach.

    Science.gov (United States)

    Reynolds, Michael J.

    An English for Special Purposes (ESP) program, devised for students of the School of Environmental Design at the English Language Centre of King Abdul Aziz University, Jeddah, is described. The course is intended to be of direct relevance to students by developing their English language skills and giving them a basic professional vocabulary. A…

  15. A structured approach to heat exchanger network retrofit design

    NARCIS (Netherlands)

    Van Reisen, J.L.B.

    2008-01-01

    Process plants have high energy consumption. Much energy can be saved by a proper design of the heat exchanger network, which contains the main heat transferring equipment of the plant. Existing plants can often be made more energy-efficient by a retrofit: the (physical) modification of the

  16. The Elaboration Theory's Procedure for Designing Instruction: A Conceptual Approach.

    Science.gov (United States)

    Reigeluth, Charles M.; Darwazeh, Afnan

    1982-01-01

    Describes the use of elaboration theory in selecting, sequencing, synthesizing, and summarizing instructional content that is predominantly conceptual in nature. The elaboration theory is summarized and the instructional design process based upon it is outlined. Six figures, a glossary, and a 27-item reference list are included. (Author/JL)

  17. Beyond Podcasting: Creative Approaches to Designing Educational Audio

    Science.gov (United States)

    Middleton, Andrew

    2009-01-01

    This paper discusses a university-wide pilot designed to encourage academics to creatively explore learner-centred applications for digital audio. Participation in the pilot was diverse in terms of technical competence, confidence and contextual requirements and there was little prior experience of working with digital audio. Many innovative…

  18. The Design Process of Corporate Universities: A Stakeholder Approach

    Science.gov (United States)

    Patrucco, Andrea Stefano; Pellizzoni, Elena; Buganza, Tommaso

    2017-01-01

    Purpose: Corporate universities (CUs) have been experiencing tremendous growth during the past years and can represent a real driving force for structured organizations. The paper aims to define the process of CU design shaped around company strategy. For each step, the authors propose specific roles, activities and methods.…

  19. Functional and aesthetic approach to design of bird feeders

    Science.gov (United States)

    Kukhta, A.; Kukhta, M.

    2015-10-01

    Anthropogenic objects which load the urban environment negatively affects the human psyche. The alternative is attracting elements of the natural environment into urban environment, of which some of the most frequently identified are birds. Attracting birds in the city is possible by means of feeders and artificial nests, however, both must be harmonious. The aim of this study is to analyze the essential functions of the feeders, and their integration into the environmental design and development of the city. On this basis an original feeder which is convenient for use by birds and attracts people's attention is developed. In this paper we apply comparative analysis of different types of feeders encountered in Tomsk, bird watching, and evaluate usability of different types of feeders from the position of their convenience both for birds and human beings. Historical-cultural analysis for determining features of the architectural and environmental design of Tomsk is carried out, the method allows us to solve engineering problems. In this study the feeder convenient for bird use is designed which blends harmoniously with the architectural design of Tomsk.

  20. The Integration of Interior Architecture Education with Digital Design Approaches

    Science.gov (United States)

    Yazicioglu, Deniz Ayse

    2011-01-01

    It is inevitable that as a result of progress in technology and the changes in the ways with which design is conceived, interior architecture schools should be updated according to these requirements and that new educational processes should be tried out. It is for this reason that the scope and aim of this study have been determined as being the…

  1. Design of experiment approach for the process optimization of ...

    African Journals Online (AJOL)

    Mulberry is considered as food-medicine herb, with specific nutritional and medicinal values. In this study, response surface methodology (RSM) was employed to optimize the ultrasonic-assisted extraction of total polysaccharide from mulberry using Box-Behnken design (BBD). Based on single factor experiments, a three ...

  2. Design with Concurrent Approach: Development and Flow Analysis ...

    African Journals Online (AJOL)

    The plastic product manufacturing industry has been growing rapidly in recent years. One of the most popular processes for making plastic parts is injection moluding. The design of injection mould is critically important to product quality and efficient product processing. Mould-making companies, who wish to maintain the ...

  3. A New Approach to Concrete Mix Design Using Computer Techniques

    African Journals Online (AJOL)

    Concrete is an essential part of most civil engineering works. Mix design of concrete is usually specified in terms of prescription or performance. The purpose of this work is to develop a model that is capable of reproducing any expected concrete strength within a specified range of cement content. In addition such a model ...

  4. Design health village with the approach of sustainable architecture ...

    African Journals Online (AJOL)

    Create structures to increase user safety as well as attracting investment and making money the prevalence in different parts of the country can benefit. For people to have this design can be found in different locations accomplished and the success and benefits enjoyed it. Keywords: Health; city health; smart; sustainability ...

  5. Electronic system level design an open-source approach

    CERN Document Server

    Rigo, Sandro; Santos, Luiz

    2014-01-01

    This book devises ESL design from the pragmatic perspective of a SystemC-based representation by showing how to build and how to use ESL languages, models and tools. It includes TLM 2.0 and step-by-step examples; it also addresses power modeling.

  6. A Danish Socio-Cultural Approach To Lighting Design

    DEFF Research Database (Denmark)

    Stidsen, Lone Mandrup; Kirkegaard, Poul Henning

    2013-01-01

    The design of new Danish hospitals is of great interest as the government is investing approximately DKK 40 billion o n creating 'super hospitals'. The architectural quality is under discussion and the goal is to incorporate evidence based knowledge to secure the users wellbeing and optimum recov...

  7. Evaluating Instructional Design Models: A Proposed Research Approach

    Science.gov (United States)

    Gropper, George L.

    2015-01-01

    Proliferation of prescriptive models in an "engineering" field is not a sign of its maturity. Quite the opposite. Materials engineering, for example, meets the criterion of parsimony. Sadly, the very large number of models in "instructional design," putatively an engineering field, raises questions about its status. Can the…

  8. A mechanistic approach to design smart scaffolds for tissue engineering

    NARCIS (Netherlands)

    Moroni, Lorenzo

    2006-01-01

    This thesis describes a library of novel 3D scaffolds designed and optimized for tissue engineering and regenerative medicine applications. Tissue engineering aims at restoring or regenerating a deamaged tissue by combining cells, derived from a patient biopsy, with a 3D porous matrix, functioning

  9. Applying a User-centred Approach to Interactive Visualization Design

    NARCIS (Netherlands)

    Wassink, I.; Kulyk, Olga Anatoliyivna; van Dijk, Elisabeth M.A.G.; van der Veer, Gerrit C.; van der Vet, P.E.; Zudilova-Seinstra, E.; Adriaansen, T.; van Liere, R.

    2008-01-01

    Analysing users in their context of work and finding out how and why they use different information resources is essential to provide interactive visualisation systems that match their goals and needs. Designers should actively involve the intended users throughout the whole process. This chapter

  10. A research approach to designing chemistry education using authentic practices

    NARCIS (Netherlands)

    Bulte, A.M.W.; Westbroek, H.B.; de Jong, O.; Pilot, A.

    2006-01-01

    We discuss how to reduce the incongruence between the outcomes (both cognitive and affective) of the conventional secondary chemistry curriculum and what is to be attained: the meaningful connection of students' learning to daily life and societal issues. This problem is addressed by a design study

  11. Sustainable flexible process innovation. Towards a new building design approach

    NARCIS (Netherlands)

    Brand, G.J.W. van den; Quanjel, E.; Zeiler, W.

    2001-01-01

    Developers and investors ofresidential and office buildings are facing large risks. A yearly loss ofcapital of approximately 50 billion EURO can be reduced by improvement of the design process. The need for more sustainable and end user oriented buildings on a background ofthe dynamics ofever

  12. Sustainability and urban density a decision based design approach

    NARCIS (Netherlands)

    Van Loon, P.P.; De Graaf, R.

    2011-01-01

    This paper concerns the definition, construction and application of a decision based design model which able the integration of the allocation of a variety of urban land uses with the distribution of different urban densities, in particular of residential urban areas. Urban planning is, among others

  13. Constructive Synergy in Design Science Research: A Comparative Analysis of Design Science Research and the Constructive Research Approach

    DEFF Research Database (Denmark)

    Piirainen, Kalle; Gonzalez, Rafael A.

    2014-01-01

    Information systems research is focused on creating knowledge which can be applied in organizations. Design science research, which specifically aims at applying existing knowledge to solve interesting and relevant business problems, has been steadily gaining support in information systems research....... However, design science research is not the only design-oriented research framework available. Accordingly, this raises the question of whether there is something to learn between the different approaches. This paper contributes to answering this question by comparing design science research...... with the constructive research approach. The conclusion is that the two approaches are similar and compatible, save for details in practical requirements and partly underlying philosophical assumptions. The main finding that arises from the comparison is, however, that there is a potential problem in claiming knowledge...

  14. Design of a Multiorder OFDM Frequency Diversity Approach

    Directory of Open Access Journals (Sweden)

    Abdeldime Mohamed Salih Abdelgader

    2015-01-01

    Full Text Available Frequency diversity is used to reduce the effect of destructive fading, so as to improve the communication quality, by passing the information symbols through multiple independently faded paths, and ensure that reliable communication is possible as long as one of these paths is strong. In this paper a multiorder orthogonal frequency division multiplexing (OFDM frequency diversity approach using properties of order theory and Hamming distance is proposed. The frequency diversity is obtained by specifying proper correlations among the transmitted symbols. As subchannels experience independent fading, at least one of the symbols may have robust signal, which can be used by the receiver to detect other symbols. Considering bit error rate (BER performance, power consumption, bandwidth utilization, and practical implementation expense, simulation results show that the proposed approach outperforms other OFDM diversity techniques, such as Maximal Ratio Combination (MRC and Space Frequency Block Coding (SFBC.

  15. A Holistic Approach to Networked Information Systems Design and Analysis

    Science.gov (United States)

    2016-04-15

    approximate dynamic program- ming algorithm that we call one-step rollout algorithm (ORA) We show that ORA results in an optimal solution extremely close to...cient Data Centers,” IIE Transactions (to appear), 2015 J13 Jonathan Ponniah, Yih-Chun Hu and P. R. Kumar, “A System-Theoretic Clean Slate Approach to...Machinery (Kumar) • Research highlighted in Industrial Engineer magazine (for potentially impactful journal articles among those that appear in IIE

  16. A technique for determining viable military logistics support alternatives

    Science.gov (United States)

    Hester, Jesse Stuart

    A look at today's US military will see them operating much beyond the scope of protecting and defending the United States. These operations now consist of, but are not limited to humanitarian aid, disaster relief, peace keeping, and conflict resolution. This broad spectrum of operational environments has necessitated a transformation of the individual military services to a hybrid force that is attempting to leverage the inherent and emerging capabilities and strengths of all those under the umbrella of the Department of Defense (DOD), this concept has been coined Joint Operations. Supporting Joint Operations requires a new approach to determining a viable military logistics support system. The logistics architecture for these operations has to accommodate scale, time, varied mission objectives, and imperfect information. Compounding the problem is the human in the loop (HITL) decision maker (DM) who is a necessary component for quickly assessing and planning logistics support activities. Past outcomes are not necessarily good indicators of future results, but they can provide a reasonable starting point for planning and prediction of specific needs for future requirements. Adequately forecasting the necessary logistical support structure and commodities needed for any resource intensive environment has progressed well beyond stable demand assumptions to one in which dynamic and nonlinear environments can be captured with some degree of fidelity and accuracy. While these advances are important, a holistic approach that allows exploration of the operational environment or design space does not exist to guide the military logistician in a methodical way to support military forecasting activities. To bridge this capability gap, a method called Adaptive Technique for Logistics Architecture Solutions (ATLAS) has been developed. This method provides a process that facilitates the use of techniques and tools that filter and provide relevant information to the DM. By doing

  17. A Classification of Constructivist Instructional Design Models Based on Learning and Teaching Approaches

    Science.gov (United States)

    Fardanesh, Hashem

    2006-01-01

    In a conceptual-analytical study using a deductive classificatory content analysis method ten constructivist instructional design models were selected, and learning/teaching approaches within each model were appraised. Using the original writings of the originators of each design model, the learning and teaching approaches employed or permitted to…

  18. Merged ontology for engineering design: Contrasting empirical and theoretical approaches to develop engineering ontologies

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Storga, M

    2009-01-01

    to developing the ontology engineering design integrated taxonomies (EDIT) with a theoretical approach in which concepts and relations are elicited from engineering design theories ontology (DO) The limitations and advantages of each approach are discussed. The research methodology adopted is to map...

  19. Smart energy households' pilot projects in the Netherlands with a design-driven approach

    NARCIS (Netherlands)

    Geelen, D.V.; Scheepens, A.; Kobus, C.; Obinna, U.; Mugge, R.; Schoormans, J.; Reinders, Angelina H.M.E.

    2013-01-01

    Residential smart grid projects can be evaluated by a design-driven approach, which focuses on gaining insights for successful product and service development by taking the end-users as a starting point. Because only little experience exists with this design-driven approach, this paper addresses how

  20. System Topology Optimization - An Approach to System Design of Electro-Hydraulic-Mechanical Systems

    DEFF Research Database (Denmark)

    Andersen, T. O.; Hansen, M. R.; Conrad, Finn

    2003-01-01

    The current paper presents an approach to system design of combined electro-hydraulic-mechanical systems. The approach is based on the concurrent handling of the topology as well as the design parameters of the mechanical, hydraulic and controller sub- systems, respectively. Based on an initial d...

  1. Antiwindup analysis and design approaches for MIMO systems

    Science.gov (United States)

    Marcopoli, Vincent R.; Phillips, Stephen M.

    1994-01-01

    Performance degradation of multiple-input multiple-output (MIMO) control systems having limited actuators is often handled by augmenting the controller with an antiwindup mechanism, which attempts to maintain system performance when limits are encountered. The goals of this paper are: (1) To develop a method to analyze antiwindup systems to determine precisely what stability and performance degradation is incurred under limited conditions. It is shown that by reformulating limited actuator commands as resulting from multiplicative perturbations to the corresponding controller requests, mu-analysis tools can be utilized to obtain quantitative measures of stability and performance degradation. (2) To propose a linear, time invariant (LTI) criterion on which to base the antiwindup design. These analysis and design methods are illustrated through the evaluation of two competing antiwindup schemes augmenting the controller of a Short Take-Off and Vertical Landing (STOVL) aircraft in transition flight.

  2. Nuclear Magnetic Resonance Spectroscopyan Evolutionary Approach to Drug Design

    Directory of Open Access Journals (Sweden)

    Neeraj Upmanyu

    2007-01-01

    Full Text Available Ever since Nuclear Magnetic Resonance (NMR spectroscopy hit the analytical scene; its capabilities and applications continue to evolve. Originally designed as a way to verify the structure of relatively small compounds, the technology of NMR has exploded and become a valuable means for studying protein structure. NMR has proved to be a valuable tool in pharmaceutical research, as it has entered new arena of drug discovery and structural genomics. NMR can provide information on the three-dimensional structures of small molecules in solution, high-molecular-weight complexes, and the details of enzyme mechanisms that can be used to aid in drug design. In the present scenario, the availability of high magnetic fields; improved software, high resolution probes, and electronics; more versatile pulse programmers; and most importantly the development of 2D, 3D and 4D NMR, have revolutionized the field of drug discovery and development.

  3. Dissolvable tattoo sensors: from science fiction to a viable technology

    Science.gov (United States)

    Cheng, Huanyu; Yi, Ning

    2017-01-01

    Early surrealistic painting and science fiction movies have envisioned dissolvable tattoo electronic devices. In this paper, we will review the recent advances that transform that vision into a viable technology, with extended capabilities even beyond the early vision. Specifically, we focus on the discussion of a stretchable design for tattoo sensors and degradable materials for dissolvable sensors, in the form of inorganic devices with a performance comparable to modern electronics. Integration of these two technologies as well as the future developments of bio-integrated devices is also discussed. Many of the appealing ideas behind developments of these devices are drawn from nature and especially biological systems. Thus, bio-inspiration is believed to continue playing a key role in future devices for bio-integration and beyond.

  4. Construction of an Instructional Design Model for Undergraduate Chemistry Laboratory Design: A Delphi Approach

    Science.gov (United States)

    Bunag, Tara

    2012-01-01

    The purpose of this study was to construct an instructional systems design model for chemistry teaching laboratories at the undergraduate level to accurately depict the current practices of design experts. This required identifying the variables considered during design, prioritizing and ordering these variables, and constructing a model. Experts…

  5. Using a Design Pattern Approach to Structure Online Course Content: Two Design Cases

    Science.gov (United States)

    Norton, Priscilla; Hathaway, Dawn

    2017-01-01

    Despite the central role that well organized and structured course content plays in engaging learners, the authors point to the absence of guidelines for organizing content in ways that meet course learning goals. Recognizing the need for a design solution and, perhaps, the need for a new design framework, design patterns are proposed as an…

  6. Critical Race Design: An Emerging Methodological Approach to Anti-Racist Design and Implementation Research

    Science.gov (United States)

    Khalil, Deena; Kier, Meredith

    2017-01-01

    This article is about introducing Critical Race Design (CRD), a research methodology that centers race and equity at the nucleus of educational opportunities by design. First, the authors define design-based implementation research (DBIR; Penuel, Fishman, Cheng, & Sabelli, 2011) as an equity-oriented education research methodology where…

  7. A stochastic approach to marine reserve design : incorporating data uncertainty

    OpenAIRE

    Beech, T.; Dowd, M.; Field, C.; Hatcher, B.; Andréfouët, Serge

    2008-01-01

    Marine reserves, or protected areas, are used to meet an array of biodiversity and conservation objectives. The design of regional networks of marine reserves is concerned with the problem of where to place the marine protected areas and how to spatially configure them. Quantitative methods for doing this provide important decision support tools for marine managers, The central problem is to balance the costs and benefits of the reserve network, whilst satisfying conservation objectives (henc...

  8. Multidisciplinary Design Optimization Under Uncertainty: An Information Model Approach (PREPRINT)

    Science.gov (United States)

    2011-03-01

    algebra of their reduced- order representations. Multicriteria optimization methods are used to determine preferred overall designs. 1 Introduction... analysis has been applied (Du and Zhang, 2010). Some authors employ various combinations of these mathemat- ical tools in a quest to propose more...utility-based stochastic portfolio problem with a single uncertain variable modeling the vehicle’s mission. In this two-level multicriteria decision

  9. Composite Fiber Recovery: Integration into a Design for Recycling Approach

    OpenAIRE

    Perry, Nicolas; Pompidou, Stéphane; Mantaux, Olivier; Gillet, Arnaud

    2014-01-01

    In industry, the use of composites, and more specially carbon fiber/thermoset matrix ones, is ever increasing. However, end-of-life solutions for these materials are still under development. In this chapter, a solution linking design strategies with a recycling process based on the solvolysis of the matrix by water under supercritical conditions is proposed. The needs and multi-disciplinary skills required for (i) taking recycling possibilities into account from the early stages of the product...

  10. Feedback – A systems approach to evaluation and course design

    Directory of Open Access Journals (Sweden)

    John Holmes

    2011-07-01

    Full Text Available This article discusses feedback and evaluation in classroom materials and in course design, very important issues for language teachers, from the point of view of systems analysis. It compares both open-loop feedback (less controlled and closed-loop feedback (more controlled and explores both the application and the consequences of choosing between one or the other within the language learning process. Apart from the theoretical discussion, examples of practical materials that integrate evaluation and meaningful meaning are provided.

  11. A metadata-driven approach to data repository design.

    Science.gov (United States)

    Harvey, Matthew J; McLean, Andrew; Rzepa, Henry S

    2017-01-01

    The design and use of a metadata-driven data repository for research data management is described. Metadata is collected automatically during the submission process whenever possible and is registered with DataCite in accordance with their current metadata schema, in exchange for a persistent digital object identifier. Two examples of data preview are illustrated, including the demonstration of a method for integration with commercial software that confers rich domain-specific data analytics without introducing customisation into the repository itself.

  12. A QFD and SERVQUAL Approach to Hotel Service Design

    OpenAIRE

    Ikiz, Aysun Kapucugil; Masoudi, Ali

    2008-01-01

    Current challenges facing the hotel service providers, such as “high customer demands on quality”, “increasing competition for high customer satisfaction” and “the demand for full services”, are directly related to better understand the attributes of hotel services and improve the service design characteristics accordingly. In service quality literature, SERVQUAL is the most widely used structure to measure customer expectations and perceptions. Quality Function Deployment (QFD) method is als...

  13. A discussion of two design approaches in Architecture

    OpenAIRE

    Zhu, Qi

    1999-01-01

    A: Architecture is a world of making. B: Architecture is a world of making the thinking. A: In my world of architecture, the thinking-of-making is a conscious mental development, while the thinking generated afterwards is autonomous. Hitherto in the design process, I am free from any burdens of the unpredictable and uncontrollable afterward "thinking". B: In my world of architecture, the making-of-thinking is structurally dependent on the thinking-of-making. Moreover, ...

  14. A modeling and simulation approach for a pyroprocess facility design

    Energy Technology Data Exchange (ETDEWEB)

    Lee, H. J.; Kim, S. H.; Park, H. S.; Park, B. S.; Yoon, J. S. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2008-08-15

    This paper provides insights about how a discrete event system modeling and simulation can be applied to a nuclear facility operation analysis. SimEvents and Stateflow in Mathworks Inc. were used for a headend process operation modeling and simulation to demonstrate a concrete DES modeling and simulation procedure. In particular, representative DES simulation results were also presented to demonstrate the analysis function such as a queuing, a stochastic analysis and a part of a reliability, availability and maintainability (RAM) analysis. These kinds of modeling and simulation are very important because they can contribute to a facility design in terms of an optimal process, an equipment layout, an efficient operation scheduling and a generic understanding for regulators, stake holders and operators and furthermore they can contribute to estimate an operational and maintenance cost. In the near future, a DES modeling and simulation technique is expected to contribute to a design study of the Korean pyroprocess facility design before its construction as well as an operation scheduling, annual throughput estimation and operating cost estimates.

  15. Parejas viables que perduran en el tiempo

    Directory of Open Access Journals (Sweden)

    Juan José Cuervo Rodríguez

    2013-01-01

    Full Text Available El presente artículo científico presenta resultados del proceso llevado a cabo en el proyecto de investigación docente "Mecanismos de autorregulación en parejas viables que perduran en el tiempo". Se soporta en una mirada compleja de la psicología basada en una epistemología de la construcción. En el ámbito metodológico, se inscribe en los estudios de terapia familiar desde una perspectiva de la comunicación humana como un todo integrado. Participaron nueve parejas. Los criterios de inclusión fueron: cinco o más años de convivencia, participación voluntaria, no presentar (ni haber presentado problemáticas especiales que ameriten intervención psicoterapéutica y la obtención de un porcentaje significativo en el uso de estrategias de comunicación asertiva en la resolución de conflictos. El método general utilizado fue el análisis de la comunicación en tarea de conversación. Los principales hallazgos señalan una estrecha relación entre el contexto de desarrollo de las parejas, la emergencia de códigos comunicacionales propios y la posibilidad de perdurar en el tiempo; también, se resalta el tipo de comunicación asertiva o constructiva, la construcción de valores como el respeto y la aceptación de las diferencias, y el deseo por vivir y construir bienestar común, como elementos constitutivos de su identidad como pareja.

  16. Service design as an approach to new service development:reflections and futures studies

    OpenAIRE

    Yu, Eun; Sangiorgi, Daniela

    2014-01-01

    This paper illustrates how, although Service Design has been described as evolving from a narrow description of a phase in New Service Development (NSD) to an approach to Service Innovation, the current Service Design research is still focused on the initial stages of NSD. Comparing existing Service Design research with foundational knowledge on NSD, the authors have proposed two complementary directions for future Service Design studies: 1) the expansion of ‘service design as a phase’ to inv...

  17. A Simulation Modeling Approach Method Focused on the Refrigerated Warehouses Using Design of Experiment

    Science.gov (United States)

    Cho, G. S.

    2017-09-01

    For performance optimization of Refrigerated Warehouses, design parameters are selected based on the physical parameters such as number of equipment and aisles, speeds of forklift for ease of modification. This paper provides a comprehensive framework approach for the system design of Refrigerated Warehouses. We propose a modeling approach which aims at the simulation optimization so as to meet required design specifications using the Design of Experiment (DOE) and analyze a simulation model using integrated aspect-oriented modeling approach (i-AOMA). As a result, this suggested method can evaluate the performance of a variety of Refrigerated Warehouses operations.

  18. A Novel Evolutionary Engineering Design Approach for Mixed-Domain Systems

    DEFF Research Database (Denmark)

    Fan, Zhun; Hu, J.; Seo, K.

    2004-01-01

    This paper presents an approach to engineering design of mixed-domain dynamic systems. The approach aims at system-level design and has two key features: first, it generates engineering designs that satisfy predefined specifications in an automatic manner; second, it can design systems belonging...... to different or mixed physical domains, such as electrical, mechanical, hydraulic, pneumatic, thermal systems and/or a mixture of them. Two important tools are used in this approach, namely, bond graphs and genetic programming. Bond graphs are useful because they are domain independent, amenable to free...

  19. Approaches to new derivatives of cellulose as designed pharmaceutical excipients

    Directory of Open Access Journals (Sweden)

    Schwarz Brigitte

    2003-01-01

    Full Text Available Recently, our group initiated a synthetic program directed at new derivatives of cellulose intended as novel pharmaceutical excipients. With several notable exceptions, the attempted regioselective introduction of chemical functionality into natural cellulose by direct chemical modification will result in heterogeneous products that are difficult to characterize and the preparation of which is insufficiently reproduceable. Approaches to the chemical polymerization of appropriate glucose monomers are available, leading to a degree of polymerization in the order of 100. However, the nature of these processes does not readily lend itself to the preparation of products comprising regularly arranged protecting groups in defined positions. We have chosen a mixed organic chemical-enzyme catalyzed approach based on a procedure of Kobayashi, Shoda, Donnelly and Church. Fluoride derivatives of cellobiose may be polymerized, under catalysis by cellobiose hydrolase, to form cellulose oligosaccharides of different chain lengths. We describe the chemical syntheses of cellobiose fluoride derivatives comprising protecting groups in defined positions of the reducing or nonreducing glucose moieties of cellobiose. Such derivatives may be polymerized to afford cellulose derivatives with protecting groups on alternate glucose units. The processing of these protected cellulose derivatives to afford novel biomimetic polymers will be described.

  20. A new approach towards hip-prosthesis design.

    Science.gov (United States)

    Huggler, A H; Jacob, H A

    1980-01-01

    A new femoral prosthesis with a stemless design, different from conventional types, has been conceived in an effort to preserve the physiological stress distribution in magnitude and direction within the living bone as far as possible. The most important feature is that the hip joint forces are transmitted directly to the cortical bone of the resected femoral neck by means of a thrust plate, which maintains the physiological stress an the proximal end of the femur. The prosthesis, the instruments required for its implantation and the surgical technique are described in detail. Up to now, 3 patients have received this new prosthesis.

  1. Modern analog filter analysis and design a practical approach

    CERN Document Server

    Raut, R

    2011-01-01

    Starting from the fundamentals, the present book describes methods of designing analog electronic filters and illustrates these methods by providing numerical and circuit simulation programs. The subject matters comprise many concepts and techniques that are not available in other text books on the market. To name a few - principle of transposition and its application in directly realizing current mode filters from well known voltage mode filters; an insight into the technological aspect of integrated circuit components used to implement an integrated circuit filter; a careful blending of basi

  2. Immunization of rodents against Hymenolepis infections using non-viable homologous oncospheres.

    Science.gov (United States)

    Fan, Ping-Chin; Chung, Wen-Cheng; Ito, Akira

    2004-12-01

    Immunity to Taiwan Taenia infection in pigs can be stimulated using homologous or heterologous non-viable Taenia oncospheres. This study was designed to determine whether homologous non-viable oncospheres could stimulate immunity to Hymenolepis infection in rodents. Hatched oncospheres were prepared from eggs of Hymenolepis diminuta, Hymenolepis nana, and Hymenolepis microstoma and kept at -70 degrees C for more than 1 month. A mixture of 500 non-viable oncospheres of each tapeworm and complete Freund's adjuvant was injected subcutaneously in four groups of Sprague-Dawley rats or ICR mice one to four times at an interval of 1 week; controls were not immunized. After immunization, each rodent was orally inoculated with three fresh active cysticercoids of H. diminuta or H. microstoma or 500 fresh eggs of H. nana. The animals were then necropsied for adult tapeworms. No rats or mice immunized with non-viable oncospheres of H. diminuta or H. nana were infected by the challenge inoculation. However, 28 of 34 mice immunized with non-viable H. microstoma oncospheres were infected after inoculation with cysticercoids. This study demonstrated complete protection against infection by homologous parasites in rats or mice immunized with non-viable oncospheres of H. diminuta and H. nana, respectively. Repeated immunization may not be required if resistance is stimulated in rodent hosts.

  3. Flood volume estimation in Switzerland using synthetic design hydrographs - a multivariate statistical approach

    OpenAIRE

    Brunner, Manuela Irene; Vannier, Olivier; Favre, Anne-Catherine; Viviroli, Daniel; Meylan, Paul; Sikorska, Anna; Seibert, Jan

    2016-01-01

    Accurate estimations of flood peaks, volumes and hydrographs are needed to design safe and cost-effective hydraulic structures. In this study, we propose a statistical approach for the estimation of the design variables peak and volume by constructing a synthetic design hydrograph. Our approach is based on fitting probability density functions to observed flood hydrographs and takes the dependence between the two variables peak and volume into account. The method consists of the following six...

  4. Suggest an Aspect-Oriented Design Approach for UML Communication Diagram

    OpenAIRE

    Nather, Mohammed F.; Saleem, Dr. Nada N.

    2013-01-01

    More and more works are done on the design of the Unified Modeling Language (UML) which is designed to help us for modeling effective object oriented software, Existing Object-Oriented design methods are not mature enough to capture non-functional requirement such as concurrency, fault tolerance, distribution and persistence of a software approach. Our approach proposed to use aspect-oriented software development (AOSD) mechanisms to solve the issues for interactions of the communication diag...

  5. Design for Survivability: An Approach to Assured Autonomy

    Science.gov (United States)

    Alexandrov, Natalia M.; Ozoroski, Thomas A.

    2016-01-01

    Rapidly expanding unmanned air traffic includes and will continue to include non-cooperative participants. Non-cooperative behavior may be due to technical failure, a lack of appropriate equipment, a careless or malicious operator. Regardless of the cause, the outcome remains: growing density of non-cooperative traffic will increase the risk of collision between unmanned vehicles and aircraft carrying humans. As a result, the degraded safety of airspace may limit access to airspace, with adverse consequences for the traveling public and the economy. Because encounters with small non-cooperative objects, such as birds or wayward drones, can happen too rapidly for an external control system to mitigate them, it is imperative that the aircraft that carry humans survive encounters with non-cooperative vehicles. To-date, design for survivability has been practiced explicitly in the military domain. Survivability against collisions in civil aviation has been limited to tolerances against bird strikes; and these tolerances have proved inadequate on occasion. The growing risk of collision with unmanned vehicles now requires the development of survivability discipline for civilian transport aircraft. The new discipline must be infused into multidisciplinary design methods, on par with traditional disciplines. In this paper, we report on a preliminary study of survivability considerations for the civil aviation domain.

  6. Heuristic urban transportation network design method, a multilayer coevolution approach

    Science.gov (United States)

    Ding, Rui; Ujang, Norsidah; Hamid, Hussain bin; Manan, Mohd Shahrudin Abd; Li, Rong; Wu, Jianjun

    2017-08-01

    The design of urban transportation networks plays a key role in the urban planning process, and the coevolution of urban networks has recently garnered significant attention in literature. However, most of these recent articles are based on networks that are essentially planar. In this research, we propose a heuristic multilayer urban network coevolution model with lower layer network and upper layer network that are associated with growth and stimulate one another. We first use the relative neighbourhood graph and the Gabriel graph to simulate the structure of rail and road networks, respectively. With simulation we find that when a specific number of nodes are added, the total travel cost ratio between an expanded network and the initial lower layer network has the lowest value. The cooperation strength Λ and the changeable parameter average operation speed ratio Θ show that transit users' route choices change dramatically through the coevolution process and that their decisions, in turn, affect the multilayer network structure. We also note that the simulated relation between the Gini coefficient of the betweenness centrality, Θ and Λ have an optimal point for network design. This research could inspire the analysis of urban network topology features and the assessment of urban growth trends.

  7. A narratological approach to interpreting and designing interstellar messages

    Science.gov (United States)

    Vakoch, Douglas A.

    2011-02-01

    Contemporary narratology (narrative theory) offers a useful framework for interpreting interstellar messages that have already been sent to potential extraterrestrial recipients, as well as for designing messages that may be transmitted in the future. In this paper, narratological concepts are used to analyze in depth a single interstellar message sequence, elucidating methods by which various parts of speech (nouns, verbs, adjectives, and adverbs) can be paired with pictures to describe the human body in motion. The concept of focalization is applied to the message sequence's use of isolation and magnification, which highlight the structure and function of the human body and its constituent parts. The challenges of interpreting gaps within narratives, as well as the setting in which events occur, are considered. The importance of closure in providing a fitting end to narratives is examined, and the plausibility of creating images that could be interpreted correctly by extraterrestrial intelligence is assessed. Narratological concepts examined here, as well as additional aspects of narrative, provide important resources for future work in interpreting and designing interstellar messages.

  8. One approach to design of speech emotion database

    Science.gov (United States)

    Uhrin, Dominik; Chmelikova, Zdenka; Tovarek, Jaromir; Partila, Pavol; Voznak, Miroslav

    2016-05-01

    This article describes a system for evaluating the credibility of recordings with emotional character. Sound recordings form Czech language database for training and testing systems of speech emotion recognition. These systems are designed to detect human emotions in his voice. The emotional state of man is useful in the security forces and emergency call service. Man in action (soldier, police officer and firefighter) is often exposed to stress. Information about the emotional state (his voice) will help to dispatch to adapt control commands for procedure intervention. Call agents of emergency call service must recognize the mental state of the caller to adjust the mood of the conversation. In this case, the evaluation of the psychological state is the key factor for successful intervention. A quality database of sound recordings is essential for the creation of the mentioned systems. There are quality databases such as Berlin Database of Emotional Speech or Humaine. The actors have created these databases in an audio studio. It means that the recordings contain simulated emotions, not real. Our research aims at creating a database of the Czech emotional recordings of real human speech. Collecting sound samples to the database is only one of the tasks. Another one, no less important, is to evaluate the significance of recordings from the perspective of emotional states. The design of a methodology for evaluating emotional recordings credibility is described in this article. The results describe the advantages and applicability of the developed method.

  9. Applying a learning design methodology in the flipped classroom approach – empowering teachers to reflect and design for learning

    Directory of Open Access Journals (Sweden)

    Evangelia Triantafyllou

    2016-05-01

    Full Text Available One of the recent developments in teaching that heavily relies on current technology is the “flipped classroom” approach. In a flipped classroom the traditional lecture and homework sessions are inverted. Students are provided with online material in order to gain necessary knowledge before class, while class time is devoted to clarifications and application of this knowledge. The hypothesis is that there could be deep and creative discussions when teacher and students physically meet. This paper discusses how the learning design methodology can be applied to represent, share and guide educators through flipped classroom designs. In order to discuss the opportunities arising by this approach, the different components of the Learning Design – Conceptual Map (LD-CM are presented and examined in the context of the flipped classroom. It is shown that viewing the flipped classroom through the lens of learning design can promote the use of theories and methods to evaluate its effect on the achievement of learning objectives, and that it may draw attention to the employment of methods to gather learner responses. Moreover, a learning design approach can enforce the detailed description of activities, tools and resources used in specific flipped classroom models, and it can make educators more aware of the decisions that have to be taken and people who have to be involved when designing a flipped classroom. By using the LD-CM, this paper also draws attention to the importance of characteristics and values of different stakeholders (i.e. institutions, educators, learners, and external agents, which influence the design and success of flipped classrooms. Moreover, it looks at the teaching cycle from a flipped instruction model perspective and adjusts it to cater for the reflection loops educators are involved when designing, implementing and re-designing a flipped classroom. Finally, it highlights the effect of learning design on the guidance

  10. A finite element approach to x-ray optics design

    Science.gov (United States)

    Honkanen, A. P.; Ferrero, C.; Guigay, J. P.; Mocella, V.

    2017-05-01

    Dynamical diffraction in a deformed (often bent) crystal is described by the Takagi equations 1 which, in general, have to be solved numerically on a regular 2-D grid of points representing a planar cross section of the crystal in which the diffraction of an incident X-ray wavefront occurs . Presently, the majority of numerical approaches are based on a finite difference solving scheme2-4 which can be easily implemented on a regular Cartesian grid but is not suitable for deformed meshes. In this case, the inner deformed crystal structure can be taken into account, but not the shape of the crystal surface if this differs substantially from a planar profile 5,6. Conversely, a finite element method (FEM) can be easily applied to a deformed mesh and serves very well to the purpose of modelling any incident wave on an arbitrarily shaped entrance surface 7 e.g. that of a bent crystal or a crystal submitted to a strong heat load 8-10. For instance, the cylindrical shape of the surface of a strongly bent crystal plate can easily be taken into account in a FEM calculation. Bent crystals are often used as focusing optical elements in Xray beamlines 11-13. In the following, we show the implementation of a general numerical framework for describing the propagation of X-rays inside a crystal based on the solution of the Takagi equations via the COMSOL Multiphysics FEM software package (www.comsol.com). A cylindrically bent crystal will be taken as an example to illustrate the capabilities of the new approach.

  11. A Participatory Design Approach for a Mobile App-Based Personal Response System

    Science.gov (United States)

    Song, Donggil; Oh, Eun Young

    2016-01-01

    This study reports on a participatory design approach including the design, development, implementation, and evaluation of a mobile app-based personal response system (PRS). The first cycle formulated initial design principles through context and needs analysis; the second utilized the collaboration with instructors and experts embodying specific…

  12. Making a Case for a Blended Approach: The Need for The Design-Based Case Study

    Science.gov (United States)

    Deaton, Cynthia C. M.; Malloy, Jacquelynn A.

    2017-01-01

    Design-based case studies address research questions that involve instructional innovations within a bounded system. This blend of case study and design-based research provides a systematic approach to examining instructional innovations that are bounded by perspective, context, and time. Design-based case studies provide a framework for engaging…

  13. Design principles for simulation games for learning clinical reasoning: A design-based research approach.

    Science.gov (United States)

    Koivisto, J-M; Haavisto, E; Niemi, H; Haho, P; Nylund, S; Multisilta, J

    2018-01-01

    Nurses sometimes lack the competence needed for recognising deterioration in patient conditions and this is often due to poor clinical reasoning. There is a need to develop new possibilities for learning this crucial competence area. In addition, educators need to be future oriented; they need to be able to design and adopt new pedagogical innovations. The purpose of the study is to describe the development process and to generate principles for the design of nursing simulation games. A design-based research methodology is applied in this study. Iterative cycles of analysis, design, development, testing and refinement were conducted via collaboration among researchers, educators, students, and game designers. The study facilitated the generation of reusable design principles for simulation games to guide future designers when designing and developing simulation games for learning clinical reasoning. This study makes a major contribution to research on simulation game development in the field of nursing education. The results of this study provide important insights into the significance of involving nurse educators in the design and development process of educational simulation games for the purpose of nursing education. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Combining ethidium monoazide treatment with real-time PCR selectively quantifies viable Batrachochytrium dendrobatidis cells.

    Science.gov (United States)

    Blooi, Mark; Martel, An; Vercammen, Francis; Pasmans, Frank

    2013-02-01

    Detection of the lethal amphibian fungus Batrachochytrium dendrobatidis relies on PCR-based techniques. Although highly accurate and sensitive, these methods fail to distinguish between viable and dead cells. In this study a novel approach combining the DNA intercalating dye ethidium monoazide (EMA) and real-time PCR is presented that allows quantification of viable B. dendrobatidis cells without the need for culturing. The developed method is able to suppress real-time PCR signals of heat-killed B. dendrobatidis zoospores by 99.9 % and is able to discriminate viable from heat-killed B. dendrobatidis zoospores in mixed samples. Furthermore, the novel approach was applied to assess the antifungal activity of the veterinary antiseptic F10(®) Antiseptic Solution. This disinfectant killed B. dendrobatidis zoospores effectively within 1 min at concentrations as low as 1:6400. Copyright © 2013 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

  15. Alloy Design Strategies Through Computational Thermodynamics and Kinetics Approaches

    Science.gov (United States)

    Arróyave, Raymundo; Li, Shengyen; Zhu, Ruixian; Karaman, Ibrahim

    In this work, we present an example in which computational thermodynamics and kinetics can be used, in conjunction with experiments and models for predicting the mechanical response of microstructure to design alloys and processing parameters in the spirit of the Materials Genome Initiative and the Integrated Computational Materials Science and Engineering (ICME) framework. Specifically, we describe the optimization of strength and ductility of so-called Transformation Induced Plasticity (TRIP) steals. We show how we can use models to predict the phase constitution of complex TRIP microstructures as a function of alloying and processing. We briefly describe how we can use experiments and simple models to relate phase constitution (amount of phases and their composition) to properties/performance. Finally, we show how we can use the established alloy/processing-microstructure-properties relations to determine alloying and processing parameters that yield optimal mechanical properties.

  16. Systems Approaches for Synthetic Biology: A Pathway Toward Mammalian Design

    Directory of Open Access Journals (Sweden)

    Rahul eRekhi

    2013-10-01

    Full Text Available We review methods of understanding cellular interactions through computation in order to guide the synthetic design of mammalian cells for translational applications, such as regenerative medicine and cancer therapies. In doing so, we argue that the challenges of engineering mammalian cells provide a prime opportunity to leverage advances in computational systems biology. We support this claim systematically, by addressing each of the principal challenges to existing synthetic bioengineering approaches—stochasticity, complexity, and scale—with specific methods and paradigms in systems biology. Moreover, we characterize a key set of diverse computational techniques, including agent-based modeling, Bayesian network analysis, graph theory, and Gillespie simulations, with specific utility towards synthetic biology. Lastly, we examine the mammalian applications of synthetic biology for medicine and health, and how computational systems biology can aid in the continued development of these applications.

  17. Presenting a Multi-level Superstructure Optimization Approach for Mechatronic System Design

    DEFF Research Database (Denmark)

    Pedersen, Henrik C.; Andersen, Torben Ole; Bech, Michael Møller

    2010-01-01

    Synergism and integration in the design process is what sets apart a Mechatronic System from a traditional, multidisciplinary system. However the typical design approach has been to divide the design problem into sub problems for each technology area (mechanics, electronics and control) and descr......Synergism and integration in the design process is what sets apart a Mechatronic System from a traditional, multidisciplinary system. However the typical design approach has been to divide the design problem into sub problems for each technology area (mechanics, electronics and control......) and describe the interface between the technologies, whereas the lack of well-established, systematic engineering methods to form the basic set-off in analysis and design of complete mechatronic systems has been obvious. The focus of the current paper is therefore to present an integrated design approach...... for mechatronic system design, utilizing a multi-level superstructure optimization based approach. Finally two design examples are presented and the possibilities and limitations of the approach are outlined....

  18. On a landscape approach to design and eco-poetic approach to Landscape

    NARCIS (Netherlands)

    Koh, J.

    2008-01-01

    For Landscape Architecture to become an academic discipline it must present its own coherent theory and methodology for the planning, designing and management of (built) landscapes. This also requires not only an articulated if difficult differentiation of planning, design and management and the

  19. a basic approach to designing e calculator and c oach to designing

    African Journals Online (AJOL)

    eobe

    vending machines ge of functions. ge of functions. For example a vending. For example a vending m to be purchased and send out item to rals which are linked to the appliance's embedded design considering embedded design considering a simple a simple. Embedded Systems, Integrated ontroller (also called a.

  20. Modelling the role of the design context in the design process: a domain-independent approach

    NARCIS (Netherlands)

    Reymen, Isabelle; Kroes, P.; Basten, T; Durling, D.; Shackleton, J.

    2002-01-01

    Domain-independent models of the design process are an important means for facilitating interdisciplinary communication and for supporting multidisciplinary design. Many so-called domain-independent models are, however, not really domain independent. We state that, to be domain independent, the

  1. Food chain design using multi criteria decision making, an approach to complex design issues

    NARCIS (Netherlands)

    Linnemann, A.R.; Hendrix, E.M.T.; Apaiah, R.K.; Boekel, van M.A.J.S.

    2015-01-01

    Designing a food supply chain for a completely new product involves many stakeholders and knowledge from disciplines in natural and social sciences. This paper describes how Multi Criteria Decision Making (MCDM) facilitated designing a food supply chain in a case of Novel Protein Foods. It made the

  2. Incomplete by Design: A Study of a Design-in-Use Approach to Systems Implementation

    DEFF Research Database (Denmark)

    Torkilsheyggi, Arnvør Martinsdóttir á; Hertzum, Morten

    2017-01-01

    In complex work settings the design of a system, including the associated work practices, must be completed in use to derive full benefit from the system. We investigate the introduction of an electronic whiteboard throughout a hospital in which management substituted a local design-in-use process...

  3. Integrated luminous and thermal design : a cold climate approach to zero-energy carbon-neutral design education

    Energy Technology Data Exchange (ETDEWEB)

    Guzowski, M.; Abraham, L. [Minnesota Univ., Minneapolis, MN (United States). School of Architecture

    2009-07-01

    In order to address environmental concerns, the School of Architecture at the University of Minnesota recently eliminated all of the required environmental technology courses in the professional graduate architecture program and replaced them with a new studio/technology hybrid course that focuses on the integration of luminous and thermal design for zero energy and carbon-neutral architecture. The purpose was to ask students to consider how architectural design can respond to global warming and climate change and to explore the role of solar design in shaping the next generation of sustainable architecture. In particular, the new course focused on a cold-climate approach to zero-energy carbon-neutral design education. It emphasized the role of daylighting, passive cooling, natural ventilation in significantly reducing or eliminating fossil fuel consumption and greenhouse gas emissions. Thermal and bioclimatic considerations for cold climate architecture were also investigated. This paper described the methods used in the design studio and how they were integrated into the ecological and environmental content of zero-energy and carbon-neutral design processes. The design studio curriculum content, methods, outcomes, and lessons learned were discussed, as well as the design tools and assessment and analytical methods. It was concluded that the integrated ecological design model succeeded in helping students to meaningfully integrate zero-energy and carbon-neutral design thinking into their personal design and decision-making processes. 5 refs., 6 figs.

  4. The design of neonatal incubators: a systems-oriented, human-centered approach.

    Science.gov (United States)

    Ferris, T K; Shepley, M M

    2013-04-01

    This report describes a multidisciplinary design project conducted in an academic setting reflecting a systems-oriented, human-centered philosophy in the design of neonatal incubator technologies. Graduate students in Architectural Design and Human Factors Engineering courses collaborated in a design effort that focused on supporting the needs of three user groups of incubator technologies: infant patients, family members and medical personnel. Design teams followed established human-centered design methods that included interacting with representatives from the user groups, analyzing sets of critical tasks and conducting usability studies with existing technologies. An iterative design and evaluation process produced four conceptual designs of incubators and supporting equipment that better address specific needs of the user groups. This report introduces the human-centered design approach, highlights some of the analysis findings and design solutions, and offers a set of design recommendations for future incubation technologies.

  5. Navigating towards Decoupled Aquaponic Systems: A System Dynamics Design Approach

    Directory of Open Access Journals (Sweden)

    Simon Goddek

    2016-07-01

    Full Text Available The classical working principle of aquaponics is to provide nutrient-rich aquacultural water to a hydroponic plant culture unit, which in turn depurates the water that is returned to the aquaculture tanks. A known drawback is that a compromise away from optimal growing conditions for plants and fish must be achieved to produce both crops and fish in the same environmental conditions. The objective of this study was to develop a theoretical concept of a decoupled aquaponic system (DAPS, and predict water, nutrient (N and P, fish, sludge, and plant levels. This has been approached by developing a dynamic aquaponic system model, using inputs from data found in literature covering the fields of aquaculture, hydroponics, and sludge treatment. The outputs from the model showed the dependency of aquacultural water quality on the hydroponic evapotranspiration rate. This result can be explained by the fact that DAPS is based on one-way flows. These one-way flows results in accumulations of remineralized nutrients in the hydroponic component ensuring optimal conditions for the plants. The study also suggests to size the cultivation area based on P availability in the hydroponic component as P is an exhaustible resource and has been identified one of the main limiting factors for plant growth.

  6. Profiling Total Viable Bacteria in a Hemodialysis Water Treatment System.

    Science.gov (United States)

    Chen, Lihua; Zhu, Xuan; Zhang, Menglu; Wang, Yuxin; Lv, Tianyu; Zhang, Shenghua; Yu, Xin

    2017-05-28

    Culture-dependent methods, such as heterotrophic plate counting (HPC), are usually applied to evaluate the bacteriological quality of hemodialysis water. However, these methods cannot detect the uncultured or viable but non-culturable (VBNC) bacteria, both of which may be quantitatively predominant throughout the hemodialysis water treatment system. Therefore, propidium monoazide (PMA)-qPCR associated with HPC was used together to profile the distribution of the total viable bacteria in such a system. Moreover, high-throughput sequencing of 16S rRNA gene amplicons was utilized to analyze the microbial community structure and diversity. The HPC results indicated that the total bacterial counts conformed to the standards, yet the bacteria amounts were abruptly enhanced after carbon filter treatment. Nevertheless, the bacterial counts detected by PMA-qPCR, with the highest levels of 2.14 × 10 7 copies/100 ml in softener water, were much higher than the corresponding HPC results, which demonstrated the occurrence of numerous uncultured or VBNC bacteria among the entire system before reverse osmosis (RO). In addition, the microbial community structure was very different and the diversity was enhanced after the carbon filter. Although the diversity was minimized after RO treatment, pathogens such as Escherichia could still be detected in the RO effluent. In general, both the amounts of bacteria and the complexity of microbial community in the hemodialysis water treatment system revealed by molecular approaches were much higher than by traditional method. These results suggested the higher health risk potential for hemodialysis patients from the up-to-standard water. The treatment process could also be optimized, based on the results of this study.

  7. PMA-Linked Fluorescence for Rapid Detection of Viable Bacterial Endospores

    Science.gov (United States)

    LaDuc, Myron T.; Venkateswaran, Kasthuri; Mohapatra, Bidyut

    2012-01-01

    The most common approach for assessing the abundance of viable bacterial endospores is the culture-based plating method. However, culture-based approaches are heavily biased and oftentimes incompatible with upstream sample processing strategies, which make viable cells/spores uncultivable. This shortcoming highlights the need for rapid molecular diagnostic tools to assess more accurately the abundance of viable spacecraft-associated microbiota, perhaps most importantly bacterial endospores. Propidium monoazide (PMA) has received a great deal of attention due to its ability to differentiate live, viable bacterial cells from dead ones. PMA gains access to the DNA of dead cells through compromised membranes. Once inside the cell, it intercalates and eventually covalently bonds with the double-helix structures upon photoactivation with visible light. The covalently bound DNA is significantly altered, and unavailable to downstream molecular-based manipulations and analyses. Microbiological samples can be treated with appropriate concentrations of PMA and exposed to visible light prior to undergoing total genomic DNA extraction, resulting in an extract comprised solely of DNA arising from viable cells. This ability to extract DNA selectively from living cells is extremely powerful, and bears great relevance to many microbiological arenas.

  8. A design thinking approach to primary ovarian insufficiency.

    Science.gov (United States)

    Martin, Lisa A; Porter, Alison G; Pelligrini, Vincent A; Schnatz, Peter F; Jiang, Xuezhi; Kleinstreuer, Nicole; Hall, Janet E; Verbiest, Sarah; Olmstead, Jill; Fair, Ryan; Falorni, Alberto; Persani, Luca; Rajkovic, Aleksandar; Mehta, Khanjan; Nelson, Lawrence M

    2017-03-01

    Most clinicians are not prepared to provide integrated personal care to address all the clinical needs of women with primary ovarian insufficiency. Design thinking is an engineering methodology used to develop and evaluate novel concepts for systems operation. Here we articulate the need for a seamlessly integrated mobile health system to support genomic research as well as patient care. We also review the pathophysiology and management of primary ovarian insufficiency. Molecular understanding regarding the pathogenesis is essential to developing strategies for prevention, earlier diagnosis, and appropriate management of the disorder. The syndrome is a chronic disorder characterized by oligo/amenorrhea and hypergonadotropic hypogonadism before age 40 years. There may be significant morbidity due to: 1) depression and anxiety related to the loss of reproductive hormones and infertility; 2) associated autoimmune adrenal insufficiency or hypothyroidism; and 3) reduced bone mineral density and increased risk of cardiovascular disease related to estrogen deficiency. Approximately 5% to 10% of women with primary ovarian insufficiency conceive and have a child. Women who develop primary ovarian insufficiency related to a premutation in FMR1 are at risk of having a child with fragile X syndrome, the most common cause of inherited intellectual disability. In most cases of spontaneous primary ovarian insufficiency no environmental exposure or genetic mechanism can be identified. As a rare disease, the diagnosis of primary ovarian insufficiency presents special challenges. Connecting patients and community health providers in real time with investigators who have the requisite knowledge and expertise would help solve this dilemma.

  9. A Simulated Annealing Approach for the Train Design Optimization Problem

    Directory of Open Access Journals (Sweden)

    Federico Alonso-Pecina

    2017-01-01

    Full Text Available The Train Design Optimization Problem regards making optimal decisions on the number and movement of locomotives and crews through a railway network, so as to satisfy requested pick-up and delivery of car blocks at stations. In a mathematical programming formulation, the objective function to minimize is composed of the costs associated with the movement of locomotives and cars, the loading/unloading operations, the number of locomotives, and the crews’ return to their departure stations. The constraints include upper bounds for number of car blocks per locomotive, number of car block swaps, and number of locomotives passing through railroad segments. We propose here a heuristic method to solve this highly combinatorial problem in two steps. The first one finds an initial, feasible solution by means of an ad hoc algorithm. The second step uses the simulated annealing concept to improve the initial solution, followed by a procedure aiming to further reduce the number of needed locomotives. We show that our results are competitive with those found in the literature.

  10. SYSTEMATIC PRINCIPLES AND METHODS OF SYMBOLIC APPROACHES IN URBAN DESIGN

    Directory of Open Access Journals (Sweden)

    BULAKH I. V

    2015-12-01

    Full Text Available Formulation of the problem. The low level of expression and personalization of mass architecture of the second half of the twentieth century connected with the spread of industrial technology and even to a greater extent with mechanistic traditionally functional relation to the average person as, abstract consumer architecture. The condition out of the critical situation is focusing on matters aesthetic, artistic understanding and harmonious image creation environment. The problem of increasing architectural and artistic level of architectural and urban planning solutions to overcome the monotony of planning and development, creating aesthetically expressive urban environment does not lose relevance over the past decades. Understanding and acceptance of enigma and dynamic development of cities encourage architects to find new design techniques that are able to provide in the future a reasonable possibility of forming artistic and aesthetic image of the modern city. Purpose. Define and systematize the principles of symbolization architectural and planning images; propose methods symbolism in the architectural planning of image of the urban environment. Conclusion based on analysis of the enhanced concept symbolizing the image of Architecture and Planning, the place, role and symbolization trends at all levels of the urban environment - planning, three-dimensional and improvement of urban areas; first identified the main stages and levels of symbolization (analohyzatsyya, schematization and alehoryzatsiya, their features and characteristics, formulated the basic principles of symbolization architectural and planning of image, namely the principles of communication between figurative analogies, transformation of subsequent circuits, switching allegorical groupings and metamorfizm ultimate goal – symbol birth .

  11. Design of psychosocial factors questionnaires: a systematic measurement approach

    Science.gov (United States)

    Vargas, Angélica; Felknor, Sarah A

    2012-01-01

    Background Evaluation of psychosocial factors requires instruments that measure dynamic complexities. This study explains the design of a set of questionnaires to evaluate work and non-work psychosocial risk factors for stress-related illnesses. Methods The measurement model was based on a review of literature. Content validity was performed by experts and cognitive interviews. Pilot testing was carried out with a convenience sample of 132 workers. Cronbach’s alpha evaluated internal consistency and concurrent validity was estimated by Spearman correlation coefficients. Results Three questionnaires were constructed to evaluate exposure to work and non-work risk factors. Content validity improved the questionnaires coherence with the measurement model. Internal consistency was adequate (α=0.85–0.95). Concurrent validity resulted in moderate correlations of psychosocial factors with stress symptoms. Conclusions Questionnaires´ content reflected a wide spectrum of psychosocial factors sources. Cognitive interviews improved understanding of questions and dimensions. The structure of the measurement model was confirmed. PMID:22628068

  12. A Lead User Approach to Universal Design - Involving Older Adults in the Design Process.

    Science.gov (United States)

    Raviselvam, Sujithra; Wood, Kristin L; Hölttä-Otto, Katja; Tam, Victoria; Nagarajan, Kamya

    2016-01-01

    The concept of Universal Design has received increasing appreciation over the past two decades. Yet, there are very few existing designs that cater to the needs of extraordinary users who experience some form of physical challenge. Previous work has shown promising results on involving users with physical challenges as lead users - users who have the potential to identify needs that could be latent among the general population. It has also been shown that older adults can act as such lead users. They can help design universal product ideas that satisfy both older adults and the general population. In this paper we build on this and examine if involving older adults in the design phase can result in universal products, products preferred by both older adults and the general population over a current option. Eighty-nine older adult participants and thirty-four general population participants took part in the study. Products were redesigned and prototyped based on the needs of older adults and tested among both populations. Results show that, although older adults and the general population did share certain needs and demands, the majority of older adults had needs and demands that were different from those of the general population. However, even though the needs differed between the populations, on average 89% of the general population participants preferred products designed based on design needs expressed by older adults over the current option. This provides further evidence supporting the use of older adults in designing products for all.

  13. Energy-aware memory management for embedded multimedia systems a computer-aided design approach

    CERN Document Server

    Balasa, Florin

    2011-01-01

    Energy-Aware Memory Management for Embedded Multimedia Systems: A Computer-Aided Design Approach presents recent computer-aided design (CAD) ideas that address memory management tasks, particularly the optimization of energy consumption in the memory subsystem. It explains how to efficiently implement CAD solutions, including theoretical methods and novel algorithms. The book covers various energy-aware design techniques, including data-dependence analysis techniques, memory size estimation methods, extensions of mapping approaches, and memory banking approaches. It shows how these techniques

  14. A simultaneous determination of related substances by high performance liquid chromatography in a drug product using quality by design approach.

    Science.gov (United States)

    Tol, Trupti; Kadam, Nilesh; Raotole, Nilesh; Desai, Anita; Samanta, Gautam

    2016-02-05

    The combination of Abacavir, Lamivudine and Dolutegravir is an anti-retroviral formulation that displays high efficacy and superiority in comparison to other anti-retroviral combinations. Analysis of related substances in this combination drug product was very challenging due to the presence of nearly thirty peaks including the three active pharmaceutical ingredients (APIs), eleven known impurities and other pharmaceutical excipients. Objective of this study was to develop a single, selective, and robust high performance liquid chromatography method for the efficient separation of all peaks. Initially, one-factor-at-a-time (OFAT) approach was adopted to develop the method. But, it could not resolve all the critical peaks in such complex matrix. This led to the advent of two different HPLC methods for the determination of related substances, one for Abacavir and Lamivudine and the other for Dolutegravir. But, since analysis of a single sample using two methods instead of one is time and resource consuming and thus expensive, an attempt was made to develop a single and robust method by adopting quality by design (QbD) principles. Design of Experiments (DoE) was applied as a tool to achieve the optimum conditions through Response surface methodology with three method variables, pH, temperature, and mobile phase composition. As the study progressed, it was discovered that establishment of the design space was not viable due to the completely distant pH requirements of the two responses, i.e. (i) retention time for Lamivudine carboxylic acid and (ii) resolution between Abacavir impurity B and unknown impurity. Eventually, neglecting one of these two responses each time, two distinguished design spaces have been established and verified. Edge of failures at both design spaces indicate high probability of failure. It therefore, becomes very important to identify the most robust zone or normal operating range (NOR) within the design space with low risk of failure and high

  15. Photocatalytic water splitting: Quantitative approaches toward photocatalysis by design

    KAUST Repository

    Takanabe, Kazuhiro

    2017-10-11

    then be altered to further improve the process. Accumulation of knowledge ranging in fields from solid-state physics to electrochemistry and the use of a multidisciplinary approach to conduct measurements and modeling in a quantitative manner are required to fully understand and improve the efficiency of photocatalysis.

  16. The EDIE method – towards an approach to collaboration-based persuasive design

    DEFF Research Database (Denmark)

    Hansen, Sandra Burri Gram

    2016-01-01

    This paper presents the initial steps towards a collaboration-based method for persuasive design – the EDIE method (Explore, Design, Implement, Evaluate). The method is inspired by Design-Based Research, but developed to combine different design approaches that have dominated the persuasive...... technology field over the past decade. The rhetorical notion of Kairos is considered a key element in the EDIE method, resulting in a distinct focus on participatory design and constructive ethics. The method is explained through a practical example of developing persuasive learning designs in collaboration...... with the Danish Ministry of Defence and the Installation Management Command....

  17. An Optimisation Approach Applied to Design the Hydraulic Power Supply for a Forklift Truck

    DEFF Research Database (Denmark)

    Pedersen, Henrik Clemmensen; Andersen, Torben Ole; Hansen, Michael Rygaard

    2004-01-01

    This paper describes the first part of a method that may be used in the design of the most energy efficient hydraulic opencircuit systems, when also considering the operational aspects of the system given in the design specifications. The method builds on a numerically based multi......-level optimisation approach, and is in the current paper exemplified through the design of the hydraulic power supply for a forklift truck. The paper first describes the prerequisites for the method and then explains the different steps in the approach to design the hydraulic system. Finally the results...

  18. Ten ways to design for disgust, sadness, and other enjoyments : A design approach to enrich product experiences with negative emotions

    NARCIS (Netherlands)

    Fokkinga, S.F.; Desmet, P.M.A.

    2013-01-01

    This paper demonstrates how designers can enrich user experiences by purposefully involving negative emotions in user-product interaction. This approach is derived from a framework of rich experience, which explains how and under what circumstances negative emotions make a product experience richer

  19. Workspace design for crane cabins applying a combined traditional approach and the Taguchi method for design of experiments.

    Science.gov (United States)

    Spasojević Brkić, Vesna K; Veljković, Zorica A; Golubović, Tamara; Brkić, Aleksandar Dj; Kosić Šotić, Ivana

    2016-01-01

    Procedures in the development process of crane cabins are arbitrary and subjective. Since approximately 42% of incidents in the construction industry are linked to them, there is a need to collect fresh anthropometric data and provide additional recommendations for design. In this paper, dimensioning of the crane cabin interior space was carried out using a sample of 64 crane operators' anthropometric measurements, in the Republic of Serbia, by measuring workspace with 10 parameters using nine measured anthropometric data from each crane operator. This paper applies experiments run via full factorial designs using a combined traditional and Taguchi approach. The experiments indicated which design parameters are influenced by which anthropometric measurements and to what degree. The results are expected to be of use for crane cabin designers and should assist them to design a cabin that may lead to less strenuous sitting postures and fatigue for operators, thus improving safety and accident prevention.

  20. A Geometric Approach for Robotic Arm Kinematics with Hardware Design, Electrical Design, and Implementation

    Directory of Open Access Journals (Sweden)

    Kurt E. Clothier

    2010-01-01

    Full Text Available This paper presents a geometric approach to solve the unknown joint angles required for the autonomous positioning of a robotic arm. A plethora of complex mathematical processes is reduced using basic trigonometric in the modeling of the robotic arm. This modeling and analysis approach is tested using a five-degree-of-freedom arm with a gripper style end effector mounted to an iRobot Create mobile platform. The geometric method is easily modifiable for similar robotic system architectures and provides the capability of local autonomy to a system which is very difficult to manually control.

  1. Quality by Design approach in the development of a magnetic transducer for biomedical measurements: preliminary results on Design Space configuration

    Science.gov (United States)

    Louzada, D. R.; Monteiro, E. C.; Rivero, A. M.; Fortaleza, L. G. S.; Barbosa, C. R. H.; Velázquez, D. R. T.; Silva, E. C.; Gusmão, L. A. P.

    2016-11-01

    The concept of Quality by Design (QbD) has been widely used by the pharmaceutical industry since 2004, changing the focus on inspections to embrace greater control in the manufacturing process. This new approach contributed to lower production costs and higher quality of medicines. This work discusses the first steps towards the implementation of a QbD approach aimed at ensuring the quality of a biomedical device under development. This device will be applied as a non-magnetic metallic foreign body localization system for surgical removal guidance. It should be highlighted that a new approach was used to define the Design Space, based on fuzzy logic rather than the typical statistical techniques.

  2. Stream habitat connectivity in the Canadian Arctic: an on-site approach to design and construction

    National Research Council Canada - National Science Library

    Baki, Abul Basar M; Zhu, David Z; Tonn, William M; Cahill, Christopher L; Courtice, Gregory J

    2016-01-01

    We developed a successful on-site approach for design and construction of stream modifications that addressed challenging remote-site conditions of limited field data and available construction materials...

  3. Holistic approach to design and implementation of a medical teleconsultation workspace

    National Research Council Canada - National Science Library

    Czekierda, Łukasz; Malawski, Filip; Wyszkowski, Przemysław

    2015-01-01

    ... in a complete and comprehensive manner. In this paper we describe our approach to design and implementation of a universal platform for imaging medicine which is based on our longstanding experience in this area...

  4. Using a Competitive Approach to Improve Military Simulation Artificial Intelligence Design

    National Research Council Canada - National Science Library

    Stoykov, Sevdalin

    2008-01-01

    ...) design can lead to improvement of the AI solutions used in military simulations. To demonstrate the potential of the competitive approach, ORTS, a real-time strategy game engine, and its competition setup are used...

  5. The demonstration of a theory-based approach to the design of localized patient safety interventions

    National Research Council Canada - National Science Library

    Taylor, Natalie; Lawton, Rebecca; Slater, Beverley; Foy, Robbie

    2013-01-01

    ...) approach for co-designing patient safety interventions. We worked with three hospitals to support the implementation of evidence-based guidance to reduce the risk of feeding into misplaced nasogastric feeding tubes...

  6. Field demonstration of new bridge approach slab designs and performance : [tech summary].

    Science.gov (United States)

    2014-06-01

    The Louisiana Department of Transportation and Development (DOTD) has launched a major e ort to solve : the bridge bump problem by changing the design of approach slabs where di erential settlement is expected. : The objective is to nd a fe...

  7. A SOCIO-CULTURAL APPROACH OF MOBILITY DESIGN FOR THE LOCAL COMMUNITY

    National Research Council Canada - National Science Library

    ALVAREZ, Jaime; KOBAYASHI, Akiyo

    2009-01-01

    This paper introduces a general framework for mobility design for low-income local communities at Mexico City that has a humanistic approach and strong appreciation of cultural factors, particularly...

  8. An approach to participatory instructional design in secondary education: an exploratory study

    NARCIS (Netherlands)

    Könings, Karen; Brand-Gruwel, Saskia; Van Merriënboer, Jeroen

    2010-01-01

    Könings, K. D., Brand-Gruwel, S., & Van Merriënboer, J. J. G. (2010). An approach to participatory instructional design in secondary education: an exploratory study. Educational Research, 52(1), 45-59.

  9. Appropriate passive design approaches for the various climatic regions in South Africa

    CSIR Research Space (South Africa)

    Conradie, Dirk CU

    2013-01-01

    Full Text Available Previous chapters, Maximising the Sun (Conradie, 2011) and SA Climate Zones and Weather Files (Conradie, 2012), gave an introduction of the current South African climatic characteristics. This chapter explores appropriate passive design approaches...

  10. Design Interactive: A Nonlinear, Multimedia Approach to Teaching Introduction to Visual Communication and Principles of Design

    Science.gov (United States)

    Palilonis, Jennifer; Butler, Darrell; Leidig-Farmen, Pamela

    2013-01-01

    As online teaching techniques continue to evolve, new opportunities surface for research and insight regarding best practices for the development and implementation of interactive, multimedia teaching and learning tools. These tools are particularly attractive for courses that lend themselves to a rich media approach. Such is the case for visual…

  11. Designing simulator-based training: an approach integrating cognitive task analysis and four-component instructional design.

    Science.gov (United States)

    Tjiam, Irene M; Schout, Barbara M A; Hendrikx, Ad J M; Scherpbier, Albert J J M; Witjes, J Alfred; van Merriënboer, Jeroen J G

    2012-01-01

    Most studies of simulator-based surgical skills training have focused on the acquisition of psychomotor skills, but surgical procedures are complex tasks requiring both psychomotor and cognitive skills. As skills training is modelled on expert performance consisting partly of unconscious automatic processes that experts are not always able to explicate, simulator developers should collaborate with educational experts and physicians in developing efficient and effective training programmes. This article presents an approach to designing simulator-based skill training comprising cognitive task analysis integrated with instructional design according to the four-component/instructional design model. This theory-driven approach is illustrated by a description of how it was used in the development of simulator-based training for the nephrostomy procedure.

  12. Design of admission medication reconciliation technology: a human factors approach to requirements and prototyping.

    Science.gov (United States)

    Lesselroth, Blake J; Adams, Kathleen; Tallett, Stephanie; Wood, Scott D; Keeling, Amy; Cheng, Karen; Church, Victoria L; Felder, Robert; Tran, Hanna

    2013-01-01

    Our objectives were to (1) develop an in-depth understanding of the workflow and information flow in medication reconciliation, and (2) design medication reconciliation support technology using a combination of rapid-cycle prototyping and human-centered design. Although medication reconciliation is a national patient safety goal, limitations both of physical environment and in workflow can make it challenging to implement durable systems. We used several human factors techniques to gather requirements and develop a new process to collect a medication history at hospital admission. We completed an ethnography and time and motion analysis of pharmacists in order to illustrate the processes used to reconcile medications. We then used the requirements to design prototype multimedia software for collecting a bedside medication history. We observed how pharmacists incorporated the technology into their physical environment and documented usability issues. Admissions occurred in three phases: (1) list compilation, (2) order processing, and (3) team coordination. Current medication reconciliation processes at the hospital average 19 minutes to complete and do not include a bedside interview. Use of our technology during a bedside interview required an average of 29 minutes. The software represents a viable proof-of-concept to automate parts of history collection and enhance patient communication. However, we discovered several usability issues that require attention. We designed a patient-centered technology to enhance how clinicians collect a patient's medication history. By using multiple human factors methods, our research team identified system themes and design constraints that influence the quality of the medication reconciliation process and implementation effectiveness of new technology. Evidence-based design, human factors, patient-centered care, safety, technology.

  13. Oligonucleotide microarrays for the detection and identification of viable beer spoilage bacteria.

    Science.gov (United States)

    Weber, D G; Sahm, K; Polen, T; Wendisch, V F; Antranikian, G

    2008-10-01

    The design and evaluation of an oligonucleotide microarray in order to detect and identify viable bacterial species that play a significant role in beer spoilage. These belong to the species of the genera Lactobacillus, Megasphaera, Pediococcus and Pectinatus. Oligonucleotide probes specific to beer spoilage bacteria were designed. In order to detect viable bacteria, the probes were designed to target the intergenic spacer regions (ISR) between 16S and 23S rRNA. Prior to hybridization the ISR were amplified by combining reverse transcriptase and polymerase chain reactions using a designed consenus primer. The developed oligonucleotide microarrays allows the detection of viable beer spoilage bacteria. This method allows the detection and discrimination of single bacterial species in a sample containing complex microbial community. Furthermore, microarrays using oligonucleotide probes targeting the ISR allow the distinction between viable bacteria with the potential to grow and non growing bacteria. The results demonstrate the feasibility of oligonucleotide microarrays as a contamination control in food industry for the detection and identification of spoilage micro-organisms within a mixed population.

  14. Asouzu's Complementary Ontology as a Foundation for a Viable ...

    African Journals Online (AJOL)

    This paper on “Asouzu's Complementary Ontology as a foundation for a viable Ethic of the Environment”, posits that an ethic of the environment can be seen as viable if it considers the whole of reality as ontologically relevant. This point of view would free environmental ethics of anthropocentric bias and its attendant ...

  15. Implementing Universal Design Strategies in Municipalities - A Multidisciplinary Approach to Universal Design and Public Health.

    Science.gov (United States)

    Jensen, Roger

    2016-01-01

    Based on a national program, the regional authorities stimulated each of the 18 municipalities in Telemark 2012-15 to plan and build promenades with universal design. The cooperation between different disciplines was an important factor for good results. The project continues from 2016.

  16. The Open Form Inducer Approach for Structure-Based Drug Design.

    Directory of Open Access Journals (Sweden)

    Daniel Ken Inaoka

    Full Text Available Many open form (OF structures of drug targets were obtained a posteriori by analysis of co-crystals with inhibitors. Therefore, obtaining the OF structure of a drug target a priori will accelerate development of potent inhibitors. In addition to its small active site, Trypanosoma cruzi dihydroorotate dehydrogenase (TcDHODH is fully functional in its monomeric form, making drug design approaches targeting the active site and protein-protein interactions unrealistic. Therefore, a novel a priori approach was developed to determination the TcDHODH active site in OF. This approach consists of generating an "OF inducer" (predicted in silico to bind the target and cause steric repulsion with flexible regions proximal to the active site that force it open. We provide the first proof-of-concept of this approach by predicting and crystallizing TcDHODH in complex with an OF inducer, thereby obtaining the OF a priori with its subsequent use in designing potent and selective inhibitors. Fourteen co-crystal structures of TcDHODH with the designed inhibitors are presented herein. This approach has potential to encourage drug design against diseases where the molecular targets are such difficult proteins possessing small AS volume. This approach can be extended to study open/close conformation of proteins in general, the identification of allosteric pockets and inhibitors for other drug targets where conventional drug design approaches are not applicable, as well as the effective exploitation of the increasing number of protein structures deposited in Protein Data Bank.

  17. Issues of organizational cybernetics and viability beyond Beer's viable systems model

    Science.gov (United States)

    Nechansky, Helmut

    2013-11-01

    The paper starts summarizing the claims of Beer's viable systems model to identify five issues any viable organizations has to deal with in an unequivocal hierarchical structure of five interrelated systems. Then the evidence is introduced for additional issues and related viable structures of organizations, which deviate from Beer's model. These issues are: (1) the establishment and (2) evolution of an organization; (3) systems for independent top-down control (like "Six Sigma"); (4) systems for independent bottom-up correction of performance problems (like "Kaizen"), both working outside a hierarchical structure; (5) pull production systems ("Just in Time") and (6) systems for checks and balances of top-level power (like boards and shareholder meetings). Based on that an evolutionary approach to organizational cybernetics is outlined, addressing the establishment of organizations and possible courses of developments, including recent developments in quality and production engineering, as well as problems of setting and changing goal values determining organizational policies.

  18. Conceptualization and application of an approach for designing healthcare software interfaces.

    Science.gov (United States)

    Kumar, Ajit; Maskara, Reena; Maskara, Sanjeev; Chiang, I-Jen

    2014-06-01

    The aim of this study is to conceptualize a novel approach, which facilitates us to design prototype interfaces for healthcare software. Concepts and techniques from various disciplines were used to conceptualize an interface design approach named MORTARS (Map Original Rhetorical To Adapted Rhetorical Situation). The concepts and techniques included in this approach are (1) rhetorical situation - a concept of philosophy provided by Bitzer (1968); (2) move analysis - an applied linguistic technique provided by Swales (1990) and Bhatia (1993); (3) interface design guidelines - a cognitive and computer science concept provided by Johnson (2010); (4) usability evaluation instrument - an interface evaluation questionnaire provided by Lund (2001); (5) user modeling via stereotyping - a cognitive and computer science concept provided by Rich (1979). A prototype interface for outpatient clinic software was designed to introduce the underlying concepts of MORTARS. The prototype interface was evaluated by thirty-two medical informaticians. The medical informaticians found the designed prototype interface to be useful (73.3%), easy to use (71.9%), easy to learn (93.1%), and satisfactory (53.2%). MORTARS approach was found to be effective in designing the prototype user interface for the outpatient clinic software. This approach might be further used to design interfaces for various software pertaining to healthcare and other domains. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. The Gestalt Approach as a Relevant Framework to Facilitate the Design Process.

    Science.gov (United States)

    Dolbec, Andre

    1996-01-01

    Demonstrates how the Gestalt Approach can be useful in facilitating systems design for educational change. This approach focuses on awareness of the process that the group is involved with and helps to create an environment where individual and group concerns can be integrated and harmonized. Discusses the "Cycle of Experience" and…

  20. Three approaches to take the user perspective into account during new product design

    NARCIS (Netherlands)

    Pals, N.; Steen, M.G.D.; Langley, D.J.; Kort, J.

    2008-01-01

    This paper addresses three different approaches which can be employed to adequately answer different questions faced by product developers. These approaches differ in the ways users themselves are involved in developing the "real" user perspective. In participatory design, products and product

  1. Analyzing SystemC Designs: SystemC Analysis Approaches for Varying Applications

    Directory of Open Access Journals (Sweden)

    Jannis Stoppe

    2015-05-01

    Full Text Available The complexity of hardware designs is still increasing according to Moore’s law. With embedded systems being more and more intertwined and working together not only with each other, but also with their environments as cyber physical systems (CPSs, more streamlined development workflows are employed to handle the increasing complexity during a system’s design phase. SystemC is a C++ library for the design of hardware/software systems, enabling the designer to quickly prototype, e.g., a distributed CPS without having to decide about particular implementation details (such as whether to implement a feature in hardware or in software early in the design process. Thereby, this approach reduces the initial implementation’s complexity by offering an abstract layer with which to build a working prototype. However, as SystemC is based on C++, analyzing designs becomes a difficult task due to the complex language features that are available to the designer. Several fundamentally different approaches for analyzing SystemC designs have been suggested. This work illustrates several different SystemC analysis approaches, including their specific advantages and shortcomings, allowing designers to pick the right tools to assist them with a specific problem during the design of a system using SystemC.

  2. A new user-centered design approach: a hair washing assistive device design for users with shoulder mobility restriction.

    Science.gov (United States)

    Wu, Fong-Gong; Ma, Min-Yuan; Chang, Ro-Han

    2009-09-01

    This study utilized a user-centered design approach as the foundation for a new Assistive Device (AD) design process. Observation and evaluation results from a Usability Context Analysis (UCA) was used to improve the analysis of Strengths, Weaknesses, Opportunities and Threats (SWOT Analysis) and the matrix of Threats, Opportunities, Weaknesses, and Strengths (TOWS matrix), resulting in two assistive device design methods named AD-SWOT and AD-TOWS. Thus, an AD-design process, tailored for designing assistive devices, was both established and tested. Owing to the information gained from using the design processes and evaluating product efficiency with various cases in the early part of the research, it was decided to use the AD-design process for the entire design process. Using this process, an adjustable hair washer for physically disabled individuals to wash their hair using normal postures was developed. Furthermore, the method derived in this study can also be applied to users suffering from single-sided shoulder-joint mobility disabilities, such as frontal flexion, scapular plan elevation, and restricted abductors.

  3. The design of Eco Board Games as an umbrella approach to sustainable product design education

    DEFF Research Database (Denmark)

    Boks, Casper; McAloone, Tim C.

    2009-01-01

    The multidisciplinarity and quickly broadening scope of sustainable product design education provide incentives for experimentation with different pedagogical techniques. One of these, involving the development of eco board games, has been used at both the Technical University Denmark and the Nor...... and the Norwegian University of Science and Technology. This paper aims to reflect on the experiences, in terms of ratonales, learning goals, possible variations of the exercise, delivered course work, and future ambitions....

  4. Design of meo constellations for galileo: towards a ''design to cost'' approach

    Science.gov (United States)

    Abbondanza, S.; Zwolska, F.

    2001-12-01

    GALILEO aims at involving Europe in a new generation of satellite navigation services. In the context of the phase A of this programme, many system options are still widely open: detailed requirements, constraints and hypotheses are not yet fully stabilised. In order to design a satellite constellation satisfying civil aviation and other users needs in this early stage of the system definition, it is necessary not only to take into account classical performance aspects, such as accuracy and availability of accuracy, but also cost constraints. The paper describes the design and dimensioning method which has led ALCATEL to propose a set of MEO constellations in the frame of the GALILEO project for ESA. It especially places emphasis upon the sensitivity of the system design to numerous parameters as well as its sensitivity to performance requirements. Potential candidate constellations obviously need to meet given performance specifications which are determined by operational aspects such as: satellite reliability, maintenance strategy (spare in orbit, launch on schedule, launch on need), deployment strategy (launcher choice, etc.). The estimated cost of a potential solution is mainly derived from the number of satellites and the deployment/maintenance strategy, but it is representative of the whole life-cycle of the constellation. Furthermore, the exhibited solution shall be "as robust as" possible to requirement or assumption changes. So, it should be a baseline solution that could be easily updated in order to take into account small upgrades. This has led to the performance of some trend analyses to understand the actual influence of some constraints or requirements on the system design, and to see how initial requirements can be efficiently relaxed in order to obtain the maximum system cost diminution for a minimum constraint relaxation. This will be very useful, if cost reduction is necessary, to quickly propose alternative or sub-solutions to the baseline one.

  5. A Learner-Centred Game-Design Approach: Impacts on Teachers' Creativity

    Science.gov (United States)

    Frossard, Frederique; Barajas, Mario; Trifonova, Anna

    2012-01-01

    This study presents an innovative pedagogical approach where teachers become game designers and engage in creative teaching practices. Within co-design training workshops, 21 Spanish primary and secondary school teachers have developed their own Game-Based Learning (GBL) scenarios, especially tailored to their teaching contexts and students…

  6. Exploring Optimization Opportunities in Four-Point Suspension Wind Turbine Drivetrains Through Integrated Design Approaches: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Sethuraman, Latha [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Quick, Julian [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Guo, Yi [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Dykes, Katherine L [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2018-02-13

    Drivetrain design has significant influence on the costs of wind power generation. Current industry practices usually approach the drivetrain design with loads and system requirements defined by the turbine manufacturer. Several different manufacturers are contracted to supply individual components from the low-speed shaft to the generator - each receiving separate design specifications from the turbine manufacturer. Increasingly, more integrated approaches to turbine design have shown promise for blades and towers. Yet, integrated drivetrain design is a challenging task owing to the complex physical behavior of the important load-bearing components, namely the main bearings, gearbox, and the generator. In this paper we combine two of NREL's systems engineering design tools, DriveSE and GeneratorSE, to enable a comprehensive system-level drivetrain optimization for the IEAWind reference turbine for land-based applications. We compare a more traditional design with integrated approaches employing decoupled and coupled design optimization. It is demonstrated that both approaches have the potential to realize notable mass savings with opportunities to lower the costs of energy.

  7. Students as Co-Creators of Teaching Approaches, Course Design, and Curricula: Implications for Academic Developers

    Science.gov (United States)

    Bovill, Catherine; Cook-Sather, Alison; Felten, Peter

    2011-01-01

    Within higher education, students' voices are frequently overlooked in the design of teaching approaches, courses and curricula. In this paper we outline the theoretical background to arguments for including students as partners in pedagogical planning processes. We present examples where students have worked collaboratively in design processes,…

  8. A Frequency Response Approach to Sliding Control Design for Hydraulic Drives

    DEFF Research Database (Denmark)

    Schmidt, Lasse; Johansen, Per; Andersen, Torben Ole

    2014-01-01

    . However, when considering hydraulic cylinder drives, such full state feedback may not be available, and alternative approaches to conventional methods may be considered. This issue is addressed in this paper in regard to tracking control design for valve controlled hydraulic cylinder drives, and a design...

  9. The Dutch IOR approach to organizational design : An alternative to business process re-engineering?

    NARCIS (Netherlands)

    van Eijnatten, FM; van der Zwaan, AH

    This paper presents the current Dutch sociotechnical design approach to integral organizational renewal in a contextual way. Both its design theory and intervention processes are reviewed and some aggregated empirical evidence is presented. Next, the paper compares the ideas developed in the Dutch

  10. "Inside Out": A Collaborative Approach to Designing Schools in England, 1945-1972

    Science.gov (United States)

    Burke, Catherine

    2009-01-01

    This article explores the European dimension of a collaborative approach to school design through the lives and relationships of a group of key individuals who in England set about transforming school in the post-war era. The philosophy and practice of this group of architects, educators, designers and policy makers, who regarded the school…

  11. Green Goggles: Designing and Teaching a General Chemistry Course to Nonmajors Using a Green Chemistry Approach

    Science.gov (United States)

    Prescott, Sarah

    2013-01-01

    A novel course using green chemistry as the context to teach general chemistry fundamentals was designed, implemented and is described here. The course design included an active learning approach, with major course graded components including a weekly blog entry, exams, and a semester project that was disseminated by wiki and a public symposium.…

  12. Web-Based Learning Support for Experimental Design in Molecular Biology: A Top-Down Approach

    Science.gov (United States)

    Aegerter-Wilmsen, Tinri; Hartog, Rob; Bisseling, Ton

    2003-01-01

    An important learning goal of a molecular biology curriculum is the attainment of a certain competence level in experimental design. Currently, undergraduate students are confronted with experimental approaches in textbooks, lectures and laboratory courses. However, most students do not reach a satisfactory level of competence in the designing of…

  13. A task based design procedure and modelling approached for industrial crystallization processes

    NARCIS (Netherlands)

    Menon, A.R.

    2006-01-01

    A synthesis-based approach to the design of crystallizers and industrial crystallization processes is introduced in this thesis. An ontology for a task-based design procedure has been developed which breaks the crystallization process into a subset of basic functions (physical tasks) which transform

  14. A Flipped Classroom Approach to Teaching Systems Analysis, Design and Implementation

    Science.gov (United States)

    Tanner, Maureen; Scott, Elsje

    2015-01-01

    This paper describes a flipped classroom approach followed to teach systems analysis, design and implementation at university level. The techniques employed are described. These techniques were underpinned by a theory of coherent practice: a pedagogy that provides a framework for the design of highly structured interventions to guide students in…

  15. Toward an Understanding of the Variation in Approaches to Analysis and Design

    Science.gov (United States)

    Box, Ilona

    2009-01-01

    This paper contributes to an understanding of the variation in approaches that information system analysts/designers use to do analysis and design. A qualitative, phenomenographic research method was used. Four categories were constituted from the data: an "ad hoc" strategy with the intention of solving the problem as quickly as…

  16. A comparison between prescriptive- and performance-based approaches in fire safety design of structures

    DEFF Research Database (Denmark)

    Budny, Iwona; Giuliani, Luisa

    2010-01-01

    A provision of an adequate consideration of both the people and structure safety is a crucial goal in a rational fire design. However, only a partial agreement concerning the general structural fire safety approach exists, and several meaningful discrepancies concerning the design and verification...

  17. Personal Leadership in Practice: A Critical Approach to Instructional Design Innovation Work

    Science.gov (United States)

    Ashbaugh, Marcia L.

    2013-01-01

    An argument is made in this article for a link between leadership and innovation, when innovation is an outcome of the work approaches and practices that underpin an educational technologist's academic course designs. The practice of instructional design (ID) is continually being challenged to rethink its conceptualization of academic course…

  18. Design of Learning Objects for Concept Learning: Effects of Multimedia Learning Principles and an Instructional Approach

    Science.gov (United States)

    Chiu, Thomas K. F.; Churchill, Daniel

    2016-01-01

    Literature suggests using multimedia learning principles in the design of instructional material. However, these principles may not be sufficient for the design of learning objects for concept learning in mathematics. This paper reports on an experimental study that investigated the effects of an instructional approach, which includes two teaching…

  19. Developing Digital Courseware for a Virtual Nano-Biotechnology Laboratory: A Design-Based Research Approach

    Science.gov (United States)

    Yueh, Hsiu-Ping; Chen, Tzy-Ling; Lin, Weijane; Sheen, Horn-Jiunn

    2014-01-01

    This paper first reviews applications of multimedia in engineering education, especially in laboratory learning. It then illustrates a model and accreditation criteria adopted for developing a specific set of nanotechnology laboratory courseware and reports the design-based research approach used in designing and developing the e-learning…

  20. A model predictive control approach to design a parameterized adaptive cruise control

    NARCIS (Netherlands)

    Naus, G.J.L.; Ploeg, J.; Molengraft, M.J.G. van de; Heemels, W.P.M.H.; Steinbuch, M.

    2010-01-01

    The combination of different desirable characteristics and situation-dependent behavior cause the design of adaptive cruise control (ACC) systems to be time consuming and tedious. This chapter presents a systematic approach for the design and tuning of an ACC, based on model predictive control

  1. Immunization of Rodents Against Hymenolepis Infections using Non-Viable Homologous Oncospheres

    Directory of Open Access Journals (Sweden)

    Ping-Chin Fan

    2004-12-01

    Full Text Available Immunity to Taiwan Taenia infection in pigs can be stimulated using homologous or heterologous nonviable Taenia oncospheres. This study was designed to determine whether homologous non-viable oncospheres could stimulate immunity to Hymenolepis infection in rodents. Hatched oncospheres were prepared from eggs of Hymenolepis diminuta, Hymenolepis nana, and Hymenolepis microstoma and kept at −70°C for more than 1 month. A mixture of 500 non-viable oncospheres of each tapeworm and complete Freund's adjuvant was injected subcutaneously in four groups of Sprague-Dawley rats or ICR mice one to four times at an interval of 1 week; controls were not immunized. After immunization, each rodent was orally inoculated with three fresh active cysticercoids of H. diminuta or H. microstoma or 500 fresh eggs of H. nana. The animals were then necropsied for adult tapeworms. No rats or mice immunized with non-viable oncospheres of H. diminuta or H. nana were infected by the challenge inoculation. However, 28 of 34 mice immunized with non-viable H. microstoma oncospheres were infected after inoculation with cysticercoids. This study demonstrated complete protection against infection by homologous parasites in rats or mice immunized with non-viable oncospheres of H. diminuta and H. nana, respectively. Repeated immunization may not be required if resistance is stimulated in rodent hosts.

  2. Concept design of DEMO divertor cassette remote handling: Simply supported beam approach

    Energy Technology Data Exchange (ETDEWEB)

    Mozzillo, Rocco [CREATE, University of Naples Federico II, DII, P.le Tecchio 80, 80125, Naples (Italy); Di Gironimo, Giuseppei, E-mail: peppe.digironimo@gmail.com [CREATE, University of Naples Federico II, DII, P.le Tecchio 80, 80125, Naples (Italy); Mäkinen, Harri [VTT Technical Research Centre of Finland, P.O. Box 1300, FI-33101 Tampere (Finland); Miccichè, Gioacchino [ENEA – CR Brasimone, I-40032 Camugnano, BO (Italy); Määttä, Timo [VTT Technical Research Centre of Finland, P.O. Box 1300, FI-33101 Tampere (Finland)

    2017-03-15

    Highlights: • The present work focused on a new approach to the design of DEMO Divertor Cassette Remote Handling Equipment. • The work provides an alternative approach to the design based on the concept of a simply supported beam. • The approach proposed focuses a Divertor Cassette mover that performs the maintenance of the three cassettes at each port. • First rough dimensioning of the main components has been provided and demonstrating the feasibility of the design solutions. • The main idea of the work consisted on a design capable to use knowledge already adopted in industrial contexts. - Abstract: The present work focused on the development of a new approach to the concept design of DEMO Divertor Cassette (DC) Remote Handling Equipment (RHE). The approach is based on three main assumptions: the DC remote handling activities and the equipment shall be simplified as much as possible; technologies well known and consolidated in the industrial context can be adopted also in the nuclear fusion field; the design of the RHE should be based on a simply supported beam approach instead of cantilever approach. In detail, during the maintenance activities the barycentre of the DC is centred with respect to DC supports. This solution could simplify the design of RHE with a consequent reduction of the design and development costs. Moreover also the DC remote handling tasks shall be simplified in order to better manage the DC maintenance processes. For this reason the DC assembly and disassembly process has been simplified dividing the main sequences in basic movements. For each movement a dedicated tool has been conceived.

  3. Separation of viable and non-viable tomato (Solanum lycopersicum L.) seeds using single seed near-infrared spectroscopy

    DEFF Research Database (Denmark)

    Shrestha, Santosh; Deleuran, Lise Christina; Gislum, René

    2017-01-01

    -viable tomato seeds of two cultivars using chemometrics. The data exploration were performed by principal component analysis (PCA). Subsequently, viable and non-viable seeds were classified by partial least squares-discriminant analysis (PLS-DA) and interval PLS-DA (iPLS-DA). The indication of clustering...... of viable and non-viable seeds were observed in the PCA of each cultivar and the pooled samples. However, the PCA did not exhibit a pattern of separation among the early, normal and late germinated tomato seeds. The NIR spectral regions of 1160–1170, 1383–1397, 1647–1666, 1860–1884 and 1915–1940 nm were...... identified as important for classification of viable and non-viable tomato seeds by iPLS-DA. The sensitivity i.e. ability to correctly identify the positive samples and specificity i.e. ability to reject the negative samples of the (iPLS-DA) model on identified spectral regions for prediction of viable...

  4. A new approach to the minimum weight/loss design of switching power converters

    Science.gov (United States)

    Lee, F. C.; Rahman, S.; Wu, C. J.; Kolacki, J.

    1981-01-01

    A new technique using the mathematical nonlinear programming ALAG is proposed to facilitate design optimizations of switching power converters. This computer-aided approach provides a minimum weight (or loss) design down to the details of component level and concurrently satisfies all related power-circuit performance requirements. It also provides such design insights as tradeoffs between power loss and system weight as the switching frequency is increased.

  5. Texture analysis of cardiac cine magnetic resonance imaging to detect non-viable segments in patients with chronic myocardial infarction.

    Science.gov (United States)

    Larroza, Andrés; López-Lereu, María P; Monmeneu, José V; Gavara, Jose; Chorro, Francisco J; Bodí, Vicente; Moratal, David

    2018-02-01

    To investigate the ability of texture analysis to differentiate between infarcted non-viable, viable, and remote segments on cardiac cine magnetic resonance imaging (MRI). This retrospective study included 50 patients suffering chronic myocardial infarction. The data was randomly split into training (30 patients) and testing (20 patients) sets. The left ventricular myocardium was segmented according to the 17-segment model in both cine and late gadolinium enhancement (LGE) MRI. Infarcted myocardium regions were identified on LGE in short-axis views. Non-viable segments were identified as those showing LGE ≥ 50%, and viable segments those showing 0 cine images. A support vector machine (SVM) classifier was trained with different combination of texture features to obtain a model that provided optimal classification performance. The best classification on testing set was achieved with local binary patterns features using a 2D + t approach, in which the features are computed by including information of the time dimension available in cine sequences. The best overall area under the receiver operating characteristic curve (AUC) were: 0.849, sensitivity of 92% to detect non-viable segments, 72% to detect viable segments, and 85% to detect remote segments. Non-viable segments can be detected on cine MRI using texture analysis and this may be used as hypothesis for future research aiming to detect the infarcted myocardium by means of a gadolinium-free approach. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  6. Green Architecture Approach on Mosque Design in Cipendawa Village, Cianjur, West Java, Indonesia

    Science.gov (United States)

    Purisari, Rahma; Safitri, Ratna; Permanasari, Eka; Hendola, Feby

    2017-06-01

    Climate change has been a global concern as many buildings are constructed and maintained without considering environmental impacts. Global warming, flood and environmental damage have become everyday phenomena. Architecture plays a vital role to in shifting design paradigm green architecture that is sustainable and environmental friendly. This research-based design investigates the implementation of green architectural approach on a mosque design at a waqf land in Cipendawa Village, Cianjur. The site is located on the hill where water catchment is required. Green architecture approach is expected to minimize negative environmental impacts and provide solution for low budget mosque.

  7. A fresh recipe for designers: HCI approach to explore the nexus between design techniques and formal methods in software development

    Directory of Open Access Journals (Sweden)

    Julian Galindo Losada

    2016-11-01

    Full Text Available Emerging companies involved in design and implementation of innovative products demand multidisciplinary teams to be competitive in the market. This need mainly exposes designers to extend their knowledge not only in User Interface elements of the design process but also in software methodologies to cover the lack of resources and expertise in start-ups. It raises the question of how designers can line up HCI techniques with best practices in software development while preserving usability and easy-to-use principles. To explore this gap, this paper proposes an approach which combines existing technology and methods by studying the nexus between HCI prototyping and software engineering. The approach is applied into a case study in the design of a virtual shop harmonizing the use of storyboards and the spiral. A comprehensive analysis is performed by using a Technology acceptance model (TAM regarding with two variables: usability and easy-to-use. The present finding underlines the positive integration of HCI techniques and formal methods without compromising user satisfaction with a potential benefit for small companies in a formation stage.

  8. A Large-Scale Design Integration Approach Developed in Conjunction with the Ares Launch Vehicle Program

    Science.gov (United States)

    Redmon, John W.; Shirley, Michael C.; Kinard, Paul S.

    2012-01-01

    This paper presents a method for performing large-scale design integration, taking a classical 2D drawing envelope and interface approach and applying it to modern three dimensional computer aided design (3D CAD) systems. Today, the paradigm often used when performing design integration with 3D models involves a digital mockup of an overall vehicle, in the form of a massive, fully detailed, CAD assembly; therefore, adding unnecessary burden and overhead to design and product data management processes. While fully detailed data may yield a broad depth of design detail, pertinent integration features are often obscured under the excessive amounts of information, making them difficult to discern. In contrast, the envelope and interface method results in a reduction in both the amount and complexity of information necessary for design integration while yielding significant savings in time and effort when applied to today's complex design integration projects. This approach, combining classical and modern methods, proved advantageous during the complex design integration activities of the Ares I vehicle. Downstream processes, benefiting from this approach by reducing development and design cycle time, include: Creation of analysis models for the Aerodynamic discipline; Vehicle to ground interface development; Documentation development for the vehicle assembly.

  9. Alloy by design : A materials genome approach to advanced high strength stainless steels for low and high temperature applications

    NARCIS (Netherlands)

    Lu, Q.; Xu, W.; Van der Zwaag, S.

    2016-01-01

    We report a computational 'alloy by design' approach which can significantly accelerate the design process and substantially reduce the development costs. This approach allows simultaneously optimization of alloy composition and heat treatment parameters based on the integration of thermodynamic,

  10. Optimal design of supply chain network under uncertainty environment using hybrid analytical and simulation modeling approach

    Science.gov (United States)

    Chiadamrong, N.; Piyathanavong, V.

    2017-04-01

    Models that aim to optimize the design of supply chain networks have gained more interest in the supply chain literature. Mixed-integer linear programming and discrete-event simulation are widely used for such an optimization problem. We present a hybrid approach to support decisions for supply chain network design using a combination of analytical and discrete-event simulation models. The proposed approach is based on iterative procedures until the difference between subsequent solutions satisfies the pre-determined termination criteria. The effectiveness of proposed approach is illustrated by an example, which shows closer to optimal results with much faster solving time than the results obtained from the conventional simulation-based optimization model. The efficacy of this proposed hybrid approach is promising and can be applied as a powerful tool in designing a real supply chain network. It also provides the possibility to model and solve more realistic problems, which incorporate dynamism and uncertainty.

  11. Overview of the design approach and prioritization of R&D activities towards an EU DEMO

    Energy Technology Data Exchange (ETDEWEB)

    Federici, G., E-mail: gianfranco.federici@euro-fusion.org [EUROfusion Consortium, Boltzmannstr. 2, Garching 85748 (Germany); Bachmann, C. [EUROfusion Consortium, Boltzmannstr. 2, Garching 85748 (Germany); Biel, W. [Institute of Energy and Climate Research, Forschungszentrum Jülich GmbH, Jülich (Germany); Department of Applied Physics, Ghent University, Ghent (Belgium); Boccaccini, L. [Karlsruhe Institute of Technology (KIT), Campus Nord Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Cismondi, F.; Ciattaglia, S.; Coleman, M. [EUROfusion Consortium, Boltzmannstr. 2, Garching 85748 (Germany); Day, C. [Karlsruhe Institute of Technology (KIT), Campus Nord Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Diegele, E.; Franke, T. [EUROfusion Consortium, Boltzmannstr. 2, Garching 85748 (Germany); Grattarola, M. [Ansaldo Nucleare, Corso Perrone 25, 16152 Genova (Italy); Hurzlmeier, H. [EUROfusion Consortium, Boltzmannstr. 2, Garching 85748 (Germany); Ibarra, A. [CIEMAT, Avda. Complutense 40, 28040 Madrid (Spain); Loving, A. [CCFE Culham Science Centre, Abingdon OX14-3DB, Oxon (United Kingdom); Maviglia, F.; Meszaros, B.; Morlock, C. [EUROfusion Consortium, Boltzmannstr. 2, Garching 85748 (Germany); Rieth, M. [Karlsruhe Institute of Technology (KIT), Campus Nord Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Shannon, M. [EUROfusion Consortium, Boltzmannstr. 2, Garching 85748 (Germany); Taylor, N. [CCFE Culham Science Centre, Abingdon OX14-3DB, Oxon (United Kingdom); and others

    2016-11-01

    Highlights: • An important objective of the EU fusion roadmap Horizon 2020 is to lay the foundation of a DEMO Fusion Power Reactor to follow ITER. • This paper describes the progress of the DEMO design and R&D activities in Europe in the EUROfusion Consortium. • Focus is on a systems engineering/design integration approach to identify technology & physics R&D requirements and address design challenges. • Preliminary design choices/sensitivity studies to explore the design space and identify/select attractive design points are described. • Initial results of work conducted by distributed project teams involving EU labs, universities, and industries in Europe are presented. - Abstract: This paper describes the progress of the DEMO design and R&D activities in Europe. The focus is on a systems engineering and design integration approach, which is recognized to be essential from an early stage to identify and address the engineering and operational challenges, and the requirements for technology and physics R&D. We present some of the preliminary design choices/sensitivity studies to explore and narrow down the design space and identify/select attractive design points. We also discuss some of the initial results of work being executed in the EUROfusion Consortium by a geographically distributed project team involving many EU laboratories, universities, and industries in Europe.

  12. Diffractive element design for resonant scanner angular correction: a beam retardation approach

    Science.gov (United States)

    Khoury, Jed; Haji-Saeed, Bahareh; Morath, Christian P.; Woods, Charles L.; Sengupta, Sandip K.; Kierstead, John

    2006-11-01

    A new approach for designing diffractive optical corrective elements with zooming capability to convert nonlinear sinusoidal scanning into linear scanning is proposed. Such a device will be useful for linearizing the angular scan of a resonant mirror scanner. The design methodology is to create a graded index of a refraction device as the reference design with its index of refraction parameters based on beam retardation through propagation in an inhomogeneous medium. The diffractive element is designed by utilizing a binarizing algorithm of the accumulated phase from transmission through the refractive element. In contrast to a prior approach, which was introduced based on the beam propagation through inhomogeneous media, the new approach takes beam diameters into consideration. This makes both the refractive element and its associated diffractive element more robust against beam fanning.

  13. ETHNIC AESTHETIC APPROACH IS NEAR PREPARATION OF FUTURE TEACHERS OF TECHNOLOGIES IN SPHERE OF DESIGN

    Directory of Open Access Journals (Sweden)

    Ihor Hevko

    2016-06-01

    Full Text Available The problem of social and cultural self-determination of the future teachers of technology. The essence of the phenomenon of personal self-determination in the context of design. It is noted that modern education is designed to state the nature of the individual that is able to further self-improvement, self-development, self-realization. The expediency of application etnoestetychnoho approach in shaping the technological culture of future teachers of technology. Proved that the situation etnoestetychnoho approach to training teachers in design technologies implemented in poliparadyhmalnomu aspect. Proved that the implementation etnoestetychnoho approach in preparing future teachers of technology in design associated with overcoming natural difficulties in the providing of innovation.

  14. Missing links between lean startup, design thinking, and experiential learning approaches in entrepreneurship education

    DEFF Research Database (Denmark)

    Ramsgaard, Michael Breum; Christensen, Marie Ernst

    2016-01-01

    , design thinking, and experiential learning be identified? • How can new concepts of learning models, taking lean startup, design thinking and experiential learning approaches into account, be developed in entrepreneurship education? Approach This 3e conference paper begins as a conceptual paper...... highlighting the theories and underlying learning models behind three pedagogical approaches within entrepreneurship education, namely lean startup, design thinking and experiential learning. The paper builds this knowledge framework in order to set the design for an empirical investigation of the proposed...... topics through a later case study. The research project will develop empirical qualitative data to further elaborate the discussion. Qualitative interviews with five entrepreneurship educators from three educational institutions will shape the platform for condensation of meaning and new knowledge...

  15. A design perspective on aligning process-centric and technology-centric approaches

    DEFF Research Database (Denmark)

    Siurdyban, Artur Henryk; Svejvig, Per; Møller, Charles

    2012-01-01

    . The purpose of this paper is to propose a direction towards aligning the process-centric and technology-centric approaches. Using the case study method, we gain insight into two implementation projects: one of an information technology (IT) system and one of a process. We compare them using design thinking...... and strategic alignment theories. Based on the discussion, we assess the shortcomings of the process-centric and technology-centric approaches and argue that a conjoint design approach is required to achieve alignment between processes and technology. From a theoretical stance, this paper offers design......-informed insights into the process/technology alignment discussion and points towards a closer integration of process and technology research agendas. The implications for practice include a direction towards design-time coordination of processes and IT systems...

  16. Keeping checkpoint/restart viable for exascale systems.

    Energy Technology Data Exchange (ETDEWEB)

    Riesen, Rolf E.; Bridges, Patrick G. (IBM Research, Ireland, Mulhuddart, Dublin); Stearley, Jon R.; Laros, James H., III; Oldfield, Ron A.; Arnold, Dorian (University of New Mexico, Albuquerque, NM); Pedretti, Kevin Thomas Tauke; Ferreira, Kurt Brian; Brightwell, Ronald Brian

    2011-09-01

    Next-generation exascale systems, those capable of performing a quintillion (10{sup 18}) operations per second, are expected to be delivered in the next 8-10 years. These systems, which will be 1,000 times faster than current systems, will be of unprecedented scale. As these systems continue to grow in size, faults will become increasingly common, even over the course of small calculations. Therefore, issues such as fault tolerance and reliability will limit application scalability. Current techniques to ensure progress across faults like checkpoint/restart, the dominant fault tolerance mechanism for the last 25 years, are increasingly problematic at the scales of future systems due to their excessive overheads. In this work, we evaluate a number of techniques to decrease the overhead of checkpoint/restart and keep this method viable for future exascale systems. More specifically, this work evaluates state-machine replication to dramatically increase the checkpoint interval (the time between successive checkpoint) and hash-based, probabilistic incremental checkpointing using graphics processing units to decrease the checkpoint commit time (the time to save one checkpoint). Using a combination of empirical analysis, modeling, and simulation, we study the costs and benefits of these approaches on a wide range of parameters. These results, which cover of number of high-performance computing capability workloads, different failure distributions, hardware mean time to failures, and I/O bandwidths, show the potential benefits of these techniques for meeting the reliability demands of future exascale platforms.

  17. Identifying Effective Design Approaches to Allocate Genotypes in Two-Phase Designs: A Case Study in Pelargonium zonale

    Directory of Open Access Journals (Sweden)

    Heike Molenaar

    2018-01-01

    Full Text Available Robust phenotypic data allow adequate statistical analysis and are crucial for any breeding purpose. Such data is obtained from experiments laid out to best control local variation. Additionally, experiments frequently involve two phases, each contributing environmental sources of variation. For example, in a former experiment we conducted to evaluate production related traits in Pelargonium zonale, there were two consecutive phases, each performed in a different greenhouse. Phase one involved the propagation of the breeding strains to obtain the stem cutting count, and phase two involved the assessment of root formation. The evaluation of the former study raised questions regarding options for improving the experimental layout: (i Is there a disadvantage to using exactly the same design in both phases? (ii Instead of generating a separate layout for each phase, can the design be optimized across both phases, such that the mean variance of a pair-wise treatment difference (MVD can be decreased? To answer these questions, alternative approaches were explored to generate two-phase designs either in phase-wise order (Option 1 or across phases (Option 2. In Option 1 we considered the scenarios (i using in both phases the same experimental design and (ii randomizing each phase separately. In Option 2, we considered the scenarios (iii generating a single design with eight replicates and splitting these among the two phases, (iv separating the block structure across phases by dummy coding, and (v design generation with optimal alignment of block units in the two phases. In both options, we considered the same or different block structures in each phase. The designs were evaluated by the MVD obtained by the intra-block analysis and the joint inter-block–intra-block analysis. The smallest MVD was most frequently obtained for designs generated across phases rather than for each phase separately, in particular when both phases of the design were

  18. Rational drug design of antineoplastic agents using 3D-QSAR, cheminformatic, and virtual screening approaches.

    Science.gov (United States)

    Vucicevic, Jelica; Nikolic, Katarina; Mitchell, John B O

    2017-07-12

    Computer-Aided Drug Design has strongly accelerated the development of novel antineoplastic agents by helping in the hit identification, optimization, and evaluation. Computational approaches such as cheminformatic search, virtual screening, pharmacophore modeling, molecular docking and dynamics have been developed and applied to explain the activity of bioactive molecules, design novel agents, increase the success rate of drug research, and decrease the total costs of drug discovery. Similarity searches and virtual screening are used to identify molecules with an increased probability to interact with drug targets of interest, while the other computational approaches are applied for the design and evaluation of molecules with enhanced activity and improved safety profile. In this review are described the main in silico techniques used in rational drug design of antineoplastic agents and presented optimal combinations of computational methods for design of more efficient antineoplastic drugs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  19. A Systematic Approach to Design High-Order Phase-Locked Loops

    DEFF Research Database (Denmark)

    Golestan, Saeed; Fernandez, Francisco Daniel Freijedo; Guerrero, Josep M.

    2015-01-01

    A basic approach to improve the performance of phase-locked loop (PLL) under adverse grid condition is to incorporate a first-order low-pass filter (LPF) into its control loop. The first-order LPF, however, has a limited ability to suppress grid disturbances. A natural thought to further improve...... the disturbance rejection capability of PLL is to use high order LPFs, resulting in high order PLLs. Application of high order LPFs, however, results in high order PLLs, which rather complicates the PLL analysis and design procedure. To overcome this challenge, a systematic method to design high order PLLs...... is presented in this letter. The suggested approach has a general theme, which means it can be applied to design the PLL control parameters regardless of the order of in-loop LPF. The effectiveness of suggested design method is confirmed through different design cases....

  20. A Function-Behavior-State Approach to Designing Human Machine Interface for Nuclear Power Plant Operators

    Science.gov (United States)

    Lin, Y.; Zhang, W. J.

    2005-02-01

    This paper presents an approach to human-machine interface design for control room operators of nuclear power plants. The first step in designing an interface for a particular application is to determine information content that needs to be displayed. The design methodology for this step is called the interface design framework (called framework ). Several frameworks have been proposed for applications at varying levels, including process plants. However, none is based on the design and manufacture of a plant system for which the interface is designed. This paper presents an interface design framework which originates from design theory and methodology for general technical systems. Specifically, the framework is based on a set of core concepts of a function-behavior-state model originally proposed by the artificial intelligence research community and widely applied in the design research community. Benefits of this new framework include the provision of a model-based fault diagnosis facility, and the seamless integration of the design (manufacture, maintenance) of plants and the design of human-machine interfaces. The missing linkage between design and operation of a plant was one of the causes of the Three Mile Island nuclear reactor incident. A simulated plant system is presented to explain how to apply this framework in designing an interface. The resulting human-machine interface is discussed; specifically, several fault diagnosis examples are elaborated to demonstrate how this interface could support operators' fault diagnosis in an unanticipated situation.

  1. CubeSat mission design based on a systems engineering approach

    Science.gov (United States)

    Asundi, S. A.; Fitz-Coy, N. G.

    With the exception of the CubeSat specification, CubeSat design and development approaches have been mostly ad hoc, which has questioned their reliability. A systems engineering approach, based on the guidelines of NASA's Systems Engineering Handbook has been developed for CubeSats to facilitate systematic design, development and address their reliability, traceability, and reusability. The CubeSat systems engineering approach, developed as a repeatable process, uses a top-down design methodology to translate mission definitions into basic building blocks, components, interfaces and tasks, that then facilitate a bottom-up development and fabrication process. Some of the design tools (e.g., N2 diagram) described in NASAs Systems Engineering Handbook are utilized early in the design phase to identify potential conflicts in the mechanical and electrical interfaces. A novel subsystem level flowdown, which transcribes the system level requirements into identifiable CubeSat subsystems, (i.e., building blocks) is described. Utilizing this approach yields full traceability from mission concept to subsystem component to flight software. Additionally, the approach facilitates the estimation of the mission overhead in terms of power, telemetry, and computation associated with each component, interface, and task.

  2. Application of the Quality by Design Approach to the Freezing Step of Freeze-Drying: Building the Design Space.

    Science.gov (United States)

    Arsiccio, Andrea; Pisano, Roberto

    2018-02-09

    The present work shows a rational method for the development of the freezing step of a freeze-drying cycle. The current approach to the selection of freezing conditions is still empirical and non-systematic, thus resulting in poor robustness of control strategy. The final aim of this work is to fill this gap, describing a rational procedure, based on mathematical modelling, for properly choosing the freezing conditions. Mechanistic models are used for the prediction of temperature profiles during freezing and dimension of ice crystals being formed. Mathematical description of the drying phase of freeze-drying is also coupled with results obtained by freezing models, thus providing a comprehensive characterization of the lyophilization process. In this framework, deep understanding of the phenomena involved is required, and, according to the Quality by Design approach, this knowledge can be used to build the design space. The step by step procedure for building the design space for freezing is thus described and examples of applications are provided. The calculated design space is validated upon experimental data and we show that it allows easy control of the freezing process and fast selection of appropriate operating conditions. Copyright © 2018. Published by Elsevier Inc.

  3. Optimization of desolvation process for fabrication of lactoferrin nanoparticles using quality by design approach.

    Science.gov (United States)

    Pandey, Abhijeet P; More, Mahesh P; Karande, Kiran P; Chitalkar, Ramesh V; Patil, Pravin O; Deshmukh, Prashant K

    2017-09-01

    The present work deals with the design and process optimization for preparation of lactoferrin nanoparticles as carrier for delivery of curcumin (CLf-NPs) using quality by design (QbD) approach. Desolvation technique was selected for preparation of Lf-NPs. The concept of QbD was followed in stepwise manner including risk analysis FMEA methodology. Plackett-Burman screening design employing eight factors and two levels was selected for screening study and custom design was selected for further analysis. Curcumin was used as model polyphenol for assessing the encapsulating efficiency of Lf-NPs.

  4. Viable Cell Culture Banking for Biodiversity Characterization and Conservation.

    Science.gov (United States)

    Ryder, Oliver A; Onuma, Manabu

    2018-02-15

    Because living cells can be saved for indefinite periods, unprecedented opportunities for characterizing, cataloging, and conserving biological diversity have emerged as advanced cellular and genetic technologies portend new options for preventing species extinction. Crucial to realizing the potential impacts of stem cells and assisted reproductive technologies on biodiversity conservation is the cryobanking of viable cell cultures from diverse species, especially those identified as vulnerable to extinction in the near future. The advent of in vitro cell culture and cryobanking is reviewed here in the context of biodiversity collections of viable cell cultures that represent the progress and limitations of current efforts. The prospects for incorporating collections of frozen viable cell cultures into efforts to characterize the genetic changes that have produced the diversity of species on Earth and contribute to new initiatives in conservation argue strongly for a global network of facilities for establishing and cryobanking collections of viable cells.

  5. Model-driven design using IEC 61499 a synchronous approach for embedded and automation systems

    CERN Document Server

    Yoong, Li Hsien; Bhatti, Zeeshan E; Kuo, Matthew M Y

    2015-01-01

    This book describes a novel approach for the design of embedded systems and industrial automation systems, using a unified model-driven approach that is applicable in both domains.  The authors illustrate their methodology, using the IEC 61499 standard as the main vehicle for specification, verification, static timing analysis and automated code synthesis.  The well-known synchronous approach is used as the main vehicle for defining an unambiguous semantics that ensures determinism and deadlock freedom. The proposed approach also ensures very efficient implementations either on small-scale embedded devices or on industry-scale programmable automation controllers (PACs). It can be used for both centralized and distributed implementations. Significantly, the proposed approach can be used without the need for any run-time support. This approach, for the first time, blurs the gap between embedded systems and automation systems and can be applied in wide-ranging applications in automotive, robotics, and industri...

  6. A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines

    Directory of Open Access Journals (Sweden)

    Ashesh Nandy

    2016-05-01

    Full Text Available The growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. Given the high cost and time requirements for new drugs development, vaccines remain as a viable alternative, but there too traditional techniques of live-attenuated or inactivated vaccines have the danger of allergenic reactions and others. Peptide vaccines have, over the last several years, begun to be looked on as more appropriate alternatives, which are economically affordable, require less time for development and hold the promise of multi-valent dosages. The developments in bioinformatics, proteomics, immunogenomics, structural biology and other sciences have spurred the growth of vaccinomics where computer assisted approaches serve to identify suitable peptide targets for eventual development of vaccines. In this mini-review we give a brief overview of some of the recent trends in computer assisted vaccine development with emphasis on the primary selection procedures of probable peptide candidates for vaccine development.

  7. A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines.

    Science.gov (United States)

    Nandy, Ashesh; Basak, Subhash C

    2016-05-04

    The growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. Given the high cost and time requirements for new drugs development, vaccines remain as a viable alternative, but there too traditional techniques of live-attenuated or inactivated vaccines have the danger of allergenic reactions and others. Peptide vaccines have, over the last several years, begun to be looked on as more appropriate alternatives, which are economically affordable, require less time for development and hold the promise of multi-valent dosages. The developments in bioinformatics, proteomics, immunogenomics, structural biology and other sciences have spurred the growth of vaccinomics where computer assisted approaches serve to identify suitable peptide targets for eventual development of vaccines. In this mini-review we give a brief overview of some of the recent trends in computer assisted vaccine development with emphasis on the primary selection procedures of probable peptide candidates for vaccine development.

  8. Missing links between lean startup, design thinking, and experiential learning approaches in entrepreneurship education

    DEFF Research Database (Denmark)

    Ramsgaard, Michael Breum; Christensen, Marie Ernst

    2016-01-01

    , design thinking, and experiential learning be identified? • How can new concepts of learning models, taking lean startup, design thinking and experiential learning approaches into account, be developed in entrepreneurship education? Approach This 3e conference paper begins as a conceptual paper...... topics through a later case study. The research project will develop empirical qualitative data to further elaborate the discussion. Qualitative interviews with five entrepreneurship educators from three educational institutions will shape the platform for condensation of meaning and new knowledge...... valuable for research in entrepreneurship education. In-depth interviews will provide data to be analyzed in combination with vignette methods that seeks to test the following research question: How do entrepreneurship educators reflect upon the three approaches lean startup, design thinking...

  9. An approach to support entries for a design failure modes and effects analysis

    Directory of Open Access Journals (Sweden)

    Banciu Felicia Veronica

    2017-01-01

    Full Text Available The design of a fixture device is very laborious, requiring consideration of many issues from series production, information on the raw part material, required precision surfaces, ensuring an appropriate orientation scheme, continue with requirements related device itself as number of parts, parts type, complexity, manageability, easy operation and maintenance. That is why realising a proper analyse regarding the possible failures associated to these issues is overwhelming. This paper’s aim is to propose an approach for collection of items necessary for starting a Design FMEA, using Functional Analysis, TRIZ functional modelling and axiomatic design approaches. The proposed approach – to extract items for a FMEA analyse – is applied to an example of an expanding mandrel regarding its internal components and theirs relations in order to accomplish the main requirement: the accurate locating and clamping of a part.

  10. New III-V cell design approaches for very high efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Lundstrom, M.S.; Melloch, M.R.; Lush, G.B.; O' Bradovich, G.J.; Young, M.P. (Purdue Univ., Lafayette, IN (United States))

    1993-01-01

    This report describes progress during the first year of a three-year project. The objective of the research is to examine new design approaches for achieving very high conversion efficiencies. The program is divided into two areas. The first centers on exploring new thin-film approaches specifically designed for III-V semiconductors. The second area centers on exploring design approaches for achieving high conversion efficiencies without requiring extremely high quality material. Research activities consisted of an experimental study of minority carrier recombination in n-type, metal-organic chemical vapor deposition (MOCVD)-deposited GaAs, an assessment of the minority carrier lifetimes in n-GaAs grown by molecular beam epitaxy, and developing a high-efficiency cell fabrication process.

  11. Design

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Pettiway, Keon

    2017-01-01

    by designers, planners, etc. (staging from above) and mobile subjects (staging from below). A research agenda for studying situated practices of mobility and mobilities design is outlined in three directions: foci of studies, methods and approaches, and epistemologies and frames of thinking. Jensen begins......In this chapter, Ole B. Jensen takes a situational approach to mobilities to examine how ordinary life activities are structured by technology and design. Using “staging mobilities” as a theoretical approach, Jensen considers mobilities as overlapping, actions, interactions and decisions...... with a brief description of how movement is studied within social sciences after the “mobilities turn” versus the idea of physical movement in transport geography and engineering. He then explains how “mobilities design” was derived from connections between traffic and architecture. Jensen concludes...

  12. Multicriteria optimization approach to design and operation of district heating supply system over its life cycle

    Science.gov (United States)

    Hirsch, Piotr; Duzinkiewicz, Kazimierz; Grochowski, Michał

    2017-11-01

    District Heating (DH) systems are commonly supplied using local heat sources. Nowadays, modern insulation materials allow for effective and economically viable heat transportation over long distances (over 20 km). In the paper a method for optimized selection of design and operating parameters of long distance Heat Transportation System (HTS) is proposed. The method allows for evaluation of feasibility and effectivity of heat transportation from the considered heat sources. The optimized selection is formulated as multicriteria decision-making problem. The constraints for this problem include a static HTS model, allowing considerations of system life cycle, time variability and spatial topology. Thereby, variation of heat demand and ground temperature within the DH area, insulation and pipe aging and/or terrain elevation profile are taken into account in the decision-making process. The HTS construction costs, pumping power, and heat losses are considered as objective functions. Inner pipe diameter, insulation thickness, temperatures and pumping stations locations are optimized during the decision-making process. Moreover, the variants of pipe-laying e.g. one pipeline with the larger diameter or two with the smaller might be considered during the optimization. The analyzed optimization problem is multicriteria, hybrid and nonlinear. Because of such problem properties, the genetic solver was applied.

  13. A Quality by Design Approach to Developing and Manufacturing Polymeric Nanoparticle Drug Products.

    Science.gov (United States)

    Troiano, Greg; Nolan, Jim; Parsons, Donald; Van Geen Hoven, Christina; Zale, Stephen

    2016-11-01

    The translation of nanomedicines from concepts to commercial products has not reached its full potential, in part because of the technical and regulatory challenges associated with chemistry, manufacturing, and controls (CMC) development of such complex products. It is critical to take a quality by design (QbD) approach to developing nanomedicines-using a risk-based approach to identifying and classifying product attributes and process parameters and ultimately developing a deep understanding of the products, processes, and platform. This article exemplifies a QbD approach used by BIND Therapeutics, Inc., to industrialize a polymeric targeted nanoparticle drug delivery platform. The focus of the approach is on CMC affairs but consideration is also given to preclinical, clinical, and regulatory aspects of pharmaceutical development. Processes are described for developing a quality target product profile and designing supporting preclinical studies, defining critical quality attributes and process parameters, building a process knowledge map, and employing QbD to support outsourced manufacturing.

  14. Severe accident approach - final report. Evaluation of design measures for severe accident prevention and consequence mitigation.

    Energy Technology Data Exchange (ETDEWEB)

    Tentner, A. M.; Parma, E.; Wei, T.; Wigeland, R.; Nuclear Engineering Division; SNL; INL

    2010-03-01

    An important goal of the US DOE reactor development program is to conceptualize advanced safety design features for a demonstration Sodium Fast Reactor (SFR). The treatment of severe accidents is one of the key safety issues in the design approach for advanced SFR systems. It is necessary to develop an in-depth understanding of the risk of severe accidents for the SFR so that appropriate risk management measures can be implemented early in the design process. This report presents the results of a review of the SFR features and phenomena that directly influence the sequence of events during a postulated severe accident. The report identifies the safety features used or proposed for various SFR designs in the US and worldwide for the prevention and/or mitigation of Core Disruptive Accidents (CDA). The report provides an overview of the current SFR safety approaches and the role of severe accidents. Mutual understanding of these design features and safety approaches is necessary for future collaborations between the US and its international partners as part of the GEN IV program. The report also reviews the basis for an integrated safety approach to severe accidents for the SFR that reflects the safety design knowledge gained in the US during the Advanced Liquid Metal Reactor (ALMR) and Integral Fast Reactor (IFR) programs. This approach relies on inherent reactor and plant safety performance characteristics to provide additional safety margins. The goal of this approach is to prevent development of severe accident conditions, even in the event of initiators with safety system failures previously recognized to lead directly to reactor damage.

  15. A decomposition approach to the design of a multiferroic memory bit

    Science.gov (United States)

    Acevedo, Ruben; Liang, Cheng-Yen; Carman, Gregory P.; Sepulveda, Abdon E.

    2017-06-01

    The objective of this paper is to present a methodology for the design of a memory bit to minimize the energy required to write data at the bit level. By straining a ferromagnetic nickel nano-dot by means of a piezoelectric substrate, its magnetization vector rotates between two stable states defined as a 1 and 0 for digital memory. The memory bit geometry, actuation mechanism and voltage control law were used as design variables. The approach used was to decompose the overall design process into simpler sub-problems whose structure can be exploited for a more efficient solution. This method minimizes the number of fully dynamic coupled finite element analyses required to converge to a near optimal design, thus decreasing the computational time for the design process. An in-plane sample design problem is presented to illustrate the advantages and flexibility of the procedure.

  16. Security-aware design for cyber-physical systems a platform-based approach

    CERN Document Server

    Lin, Chung-Wei

    2017-01-01

    Addressing the rising security issues during the design stages of cyber-physical systems, this book develops a systematic approach to address security at early design stages together with all other design constraints. Cyber-attacks become more threatening as systems are becoming more connected with the surrounding environment, infrastructures, and other systems. Security mechanisms can be designed to protect against attacks and meet security requirements, but there are many challenges of applying security mechanisms to cyber-physical systems including open environments, limited resources, strict timing requirements, and large number of devices. Designed for researchers and professionals, this book is valuable for individuals working in network systems, security mechanisms, and system design. It is also suitable for advanced-level students of computer science. .

  17. From Participatory Design and Ontological Ethics, Towards an Approach to Constructive Ethics

    DEFF Research Database (Denmark)

    Hansen, Sandra Burri Gram; Ryberg, Thomas

    2015-01-01

    This paper explores, analyses and discusses the potential of applying Danish theologian and philosopher K.E. Løgstrup’s ontological approach to ethics, when planning and conducting participatory design activities. By doing so, ethical considerations, will transform from being a summative evaluation....... These are principles that practitioners may consider when planning e.g. workshops in order to ensure that the activities facilitate both the design process and establish an ethical foundation for the design process. In addition to the theoretical contribution of the paper, the notion of constructive ethics...... is exemplified in practice by on-going research in the cross field between persuasive design and learning, carried out in collaboration with the Danish Military. Previous research has suggested that both participatory design and ethics may be essential to persuasive design in theory and in practice. However...

  18. Conceptual Design of Environmentally Friendly Rotorcraft - A Comparison of NASA and ONERA Approaches

    Science.gov (United States)

    Russell, Carl; Basset, Pierre-Marie

    2015-01-01

    In 2011, a task was initiated under the US-French Project Agreement on rotorcraft studies to collaborate on design methodologies for environmentally friendly rotorcraft. This paper summarizes the efforts of that collaboration. The French and US aerospace agencies, ONERA and NASA, have their own software toolsets and approaches to rotorcraft design. The first step of this research effort was to understand how rotorcraft impact the environment, with the initial focus on air pollution. Second, similar baseline helicopters were developed for a passenger transport mission, using NASA and ONERA rotorcraft design software tools. Comparisons were made between the designs generated by the two tools. Finally, rotorcraft designs were generated targeting reduced environmental impact. The results show that a rotorcraft design that targets reduced environmental impact can be significantly different than one that targets traditional cost drivers, such as fuel burn and empty weight.

  19. A Multilevel Approach for Social Transformations and its Implications on Service Design Education

    DEFF Research Database (Denmark)

    Morelli, Nicola; Götzen, Amalia De

    2017-01-01

    This paper is looking at two parallel transformations -in the methodological approach to service design and in the way new social initiatives are designing new solutions – to suggest a framework to re-organise service design education. The paradigmatic framework for the service design discipline...... be observed in society, with the emergence of new organisational forms, based on collaboration, P2P and sharing concepts, which have a disruptive power over the existing social and economic system. The new initiatives, are often promoted and controlled by citizens, users or constellation of stakeholders...... perspective, in which the designer (and consequently the service provider) was deciding modes and characteristics of value creation, to a perspective in which the designer/service provider is simply mediating the process of co-creation by generating means that support social transformation. This paper...

  20. A new approach for automatic control modeling, analysis and design in fully fuzzy environment

    OpenAIRE

    Gabr, Walaa Ibrahim

    2015-01-01

    The paper presents a new approach for the modeling, analysis and design of automatic control systems in fully fuzzy environment based on the normalized fuzzy matrices. The approach is also suitable for determining the propagation of fuzziness in automatic control and dynamical systems where all system coefficients are expressed as fuzzy parameters. A new consolidity chart is suggested based on the recently newly developed system consolidity index for testing the susceptibility of the system t...