WorldWideScience

Sample records for vessels part vii

  1. Jonckheere Double Star Photometry - Part VII: Aquarius

    Science.gov (United States)

    Knapp, Wilfried R. A.

    2017-10-01

    If any double star discoverer is in urgent need of photometry then it is Jonckheere. There are over 3000 Jonckheere objects listed in the WDS catalog and a good part of them with magnitudes obviously far too bright. This report covers the Jonckheere objects in the constellation Aquarius. One image per object was taken with V-filter to allow for visual magnitude measurement by differential pho-tometry. All objects were additionally checked for common proper motion by comparing 2MASS to GAIA DR1 positions and a rather surprisingly large part of the objects qualify indeed as potential CPM pairs. For a few objects also WDS position errors were found.

  2. 40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes VII Appendix VII to Part 268 Protection of Environment ENVIRONMENTAL... VII to Part 268—LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes Table 1—Effective...

  3. 40 CFR Appendix Vii to Part 266 - Health-Based Limits for Exclusion of Waste-Derived Residues*

    Science.gov (United States)

    2010-07-01

    ... Waste-Derived Residues* VII Appendix VII to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Pt. 266, App. VII Appendix VII to Part 266—Health...

  4. Japanese contributions to IAEA INTOR workshop, phase two A, part 2 chapter VII: technical benefit

    International Nuclear Information System (INIS)

    Itoh, Shin-ichi; Iida, Hiromasa; Tomabechi, Ken; Tone, Tatsuzo; Fujisawa, Noboru.

    1985-07-01

    This report corresponds to Chapter VII of Japanese contribution report to IAEA INTOR Workshop, Phase Two A, Part 2. The purpose of technical benefit study is to examine the implications of having different manufacturers fabricate components of a major system of INTOR. A systematic examinations of advantages and disadvantages of designing and fabricating major INTOR components in the frame of one international joint projects is performed. (author)

  5. Design of pressure vessels. Part 2

    International Nuclear Information System (INIS)

    Grandemange, J.M.

    2008-01-01

    This document deals with the classification of stresses, necessary for the implementation of the mechanical code criteria defined for the pressure vessels of PWR-type reactors. It describes the general approach of design, analysis, and in-service monitoring, the regulatory tests and the modalities of equivalence between industrial construction codes. Content: 1 - damage modes and stresses classification: context, general approach, example of application; 2 - from the design stage to the in-service monitoring: liabilities, design conditions, materials choice and dimensioning, analysis, particular case of pipes and valve parts, in-service monitoring; 3 - regulatory tests: context, tests prescribed by the design and construction rules of PWR mechanical components (RCC-M); 4 - equivalence possibilities between codes: codes for nuclear reactor equipments, convergence between industrial codes and standards; 5 - conclusion. (J.S.)

  6. Design of pressure vessels. Part 1

    International Nuclear Information System (INIS)

    Grandemange, J.M.

    2008-01-01

    The equipments and loops of PWR reactors are basically pressure vessels. Their specificities concern the integrity warranties that must be implemented considering their importance for the reactors safety. Thus, stress is put on the exhaustiveness of the prevention of in-service degradation and on the safety scenarios considered. The second specificity concerns the possibility of activation of wear and corrosion products during their flow inside the reactor core. This second aspect leads to some constraints on the choice of the materials used and on the surface coating of the inside wall of big components of the primary circuit. The aim of this document is to develop the general approach adopted for the design of the pressure vessels of PWR fluid loops, and to stress more particularly on the nuclear particularities of these equipments. Some extensions of these rules to high temperature resistant materials (FBR-type reactors) are also evoked. Content: General considerations: design basis of pressure vessels, risk analysis and design conditions, ruining paths and safety coefficients; 2 - damage prevention for excessive deformation: definitions, criteria; 3 - prevention of the plastic instability damage: definition, criteria; 4 - buckling prevention: definition and mechanisms, rules and criteria; 5 - prevention of progressive deformation damage: definitions, plastic adaptation, plastic accommodation, progressive deformation; 6 - prevention of fatigue damage: definitions, general prevention approach, design fatigue curves, analytic approach, particular aspects, analysis of zones with geometrical singularity; 7 - prevention of sudden rupture damage: fragile rupture and ductile tear, general approach, analytic criteria, irradiation and aging effects; 8 - other potential damages; 9 - conclusion. (J.S.)

  7. Y-12 Construction/Demolition Landfill VII: Permit application: Part 1 and 2

    International Nuclear Information System (INIS)

    1992-04-01

    The United States Department of Energy (DOE) has three major operating facilities on the DOE Oak Ridge Reservation (ORR) at Oak Ridge, Tennessee: the Y-12 Plant, the K-25 Site, and the Oak Ridge National Laboratory (ORNL). Operations associated with the DOE energy research and production facilities at Oak Ridge result in the production of several types of waste materials. Disposal of solid waste (as defined in the Solid Waste Processing and Disposal Rules for Tennessee) in disposal facilities operated by the Y-12 Plant is the responsibility of Y-12 Waste Management Division (MWD). The WMD is proposing to develop a facility that will include two new disposal units: one for construction/demolition waste and spoil and one for industrial solid waste. This manual describes the closure and post-closure plans for the construction/demolition waste and spoil disposal unit. This disposal unit is referred to as the Y-12 Construction/Demolition Landfill VII (CD-VII) and is to be operated by the Y-12 Plant for the DOE. This will be a Tennessee Department of Environment and Conservation/Division of Solid Waste Management (TDEC/DSWM) Class IV disposal unit

  8. Proceedings of the EMU Conference on Foreign Languages for Business and the Professions (Dearborn, Michigan, April 5-7, 1984). Part VII: German for Business and the Professions.

    Science.gov (United States)

    Voght, Geoffrey M., Ed.

    Part VII of the proceedings contains five presentations. They are: "German for the Professions: Specialized German for Engineering and the Sciences" (Hannelore Lehr); "German for Business and Economics: A Three-Level Program at Georgetown University" (Barbara Z. Harding); "German for Business and Economics: Criteria for Selection of Specialized…

  9. Heavy Section Steel Technology Program. Part II. Intermediate vessel testing

    International Nuclear Information System (INIS)

    Whitman, G.D.

    1975-01-01

    The testing of the intermediate pressure vessels is a major activity under the Heavy Section Steel Technology Program. A primary objective of these tests is to develop or verify methods of fracture prediction, through the testing of selected structures and materials, in order that a valid basis can be established for evaluating the serviceability and safety of light-water reactor pressure vessels. These vessel tests were planned with sufficiently specific objectives that substantial quantitative weight could be given to the results. Each set of testing conditions was chosen so as to provide specific data by which analytical methods of predicting flaw growth, and in some cases crack arrest, could be evaluated. Every practical effort was made to assure that results would be relevant to some aspect of real reactor pressure vessel performance through careful control of material properties, selection of test temperatures, and design of prepared flaws. 5 references

  10. Forging technology for large nuclear pressure vessel parts

    International Nuclear Information System (INIS)

    Kakimoto, Hideki; Ikegami, Tomonori

    2014-01-01

    The increasing output of nuclear power generation calls for larger vessels for next-generation nuclear power plants. A vessel with an increased diameter requires increased load for its forging, which can make it difficult to use a conventional solid die. In order to reduce the forging load, a rotary incremental forging method has been applied to hot forging. This method includes pressing and rotating a material in an incremental manner such that a target shape is obtained. This study aimed at improving the accuracy of numerical simulation for the rotary incremental forging to reduce the load when forging large vessels. This has enabled the temperature of the material and flow stress to be precisely predicted; an example of this is reported in the paper. Specifically, the heat transfer coefficient to be used for the numerical simulation had been determined experimentally from a small-scale hot-forging. The reduction of the flow stress associated with incremental forging, had been deduced from a compression test, and the value was applied to the numerical simulation. A preform was designed on the basis of the above simulation to perform a 1/1 size scale experiment. A precision of better than 5% has been confirmed for the shape prediction. (author)

  11. Behaviour of Viscoelastic - Viscoplastic Spheres and Cylinders - Partly Plastic Vessel Walls

    DEFF Research Database (Denmark)

    Ottosen, N. Saabye

    1985-01-01

    The material model consists of a viscoelastic Burgers element and an additional viscoplastic Bingham element when the effective stress exceeds the yield stress. For partly plastic vessel walls, expressions are derived for the stress and strain state in pressurised or relaxation loaded thick......-walled cylinders in plane strain and spheres. For the spherical problem, the material compressibility is accounted for. The influence of the different material parameters on the behaviour of the vessels is evaluated. It is shown that the magnitude of the Maxwell viscosity is of major importance for the long......-term behaviour of thick-walled partly plastic vessels....

  12. Prediction and experimental verification of performance of box type solar cooker. Part II: Cooking vessel with depressed lid

    International Nuclear Information System (INIS)

    Reddy, Avala Raji; Rao, A.V. Narasimha

    2008-01-01

    Our previous article (Part I) discussed the theoretical and experimental study of the performance boost obtained by a cooking vessel with central cylindrical cavity on lugs when compared to that of a conventional cylindrical vessel on floor/lugs. This article compares the performance of the cooking vessel with depressed lid on lugs with that of the conventional vessel on lugs. A mathematical model is presented to understand the heat flow process to the cooking vessel and, thereby, to the food material. It is found from the experiments that the cooking vessel with depressed lid results in higher temperature of the thermic fluid loaded in the cooking vessel compared to that of the thermic fluid kept in the conventional vessel when both are placed on lugs. Similar results were obtained by modeling the process mathematically. The average improvement of performance of the vessel with depressed lid is found to be 8.4% better than the conventional cylindrical vessel

  13. BUGJEFF311.BOLIB (JEFF-3.1.1) and BUGENDF70.BOLIB (ENDF/B-VII.0) - Generation Methodology and Preliminary Testing of two ENEA-Bologna Group Cross Section Libraries for LWR Shielding and Pressure Vessel Dosimetry

    Science.gov (United States)

    Pescarini, Massimo; Sinitsa, Valentin; Orsi, Roberto; Frisoni, Manuela

    2016-02-01

    Two broad-group coupled neutron/photon working cross section libraries in FIDO-ANISN format, dedicated to LWR shielding and pressure vessel dosimetry applications, were generated following the methodology recommended by the US ANSI/ANS-6.1.2-1999 (R2009) standard. These libraries, named BUGJEFF311.BOLIB and BUGENDF70.BOLIB, are respectively based on JEFF-3.1.1 and ENDF/B-VII.0 nuclear data and adopt the same broad-group energy structure (47 n + 20 γ) of the ORNL BUGLE-96 similar library. They were respectively obtained from the ENEA-Bologna VITJEFF311.BOLIB and VITENDF70.BOLIB libraries in AMPX format for nuclear fission applications through problem-dependent cross section collapsing with the ENEA-Bologna 2007 revision of the ORNL SCAMPI nuclear data processing system. Both previous libraries are based on the Bondarenko self-shielding factor method and have the same AMPX format and fine-group energy structure (199 n + 42 γ) as the ORNL VITAMIN-B6 similar library from which BUGLE-96 was obtained at ORNL. A synthesis of a preliminary validation of the cited BUGLE-type libraries, performed through 3D fixed source transport calculations with the ORNL TORT-3.2 SN code, is included. The calculations were dedicated to the PCA-Replica 12/13 and VENUS-3 engineering neutron shielding benchmark experiments, specifically conceived to test the accuracy of nuclear data and transport codes in LWR shielding and radiation damage analyses.

  14. Factor VII deficiency

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000548.htm Factor VII deficiency To use the sharing features on this page, please enable JavaScript. Factor VII (seven) deficiency is a disorder caused by a ...

  15. 33 CFR Appendix B to Part 155 - Determining and Evaluating Required Response Resources for Vessel Response Plans

    Science.gov (United States)

    2010-07-01

    ... Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Pt. 155, App. B Appendix B to Part 155—Determining and... environment. For example, vessels moving from the ocean to a river port must identify appropriate equipment...

  16. Photoreactivity of biologically active compounds. VII. Interaction of antimalarial drugs with melanin in vitro as part of phototoxicity screening.

    Science.gov (United States)

    Kristensen, S; Orsteen, A L; Sande, S A; Tønnesen, H H

    1994-10-01

    The drugs commonly used in the treatment of malaria are photochemically unstable. Several of these compounds accumulate in melanin-rich tissues and cause toxic reactions which may be light induced. As part of the screening of the photochemical properties and phototoxic capabilities of antimalarials, the in vitro interaction of eight antimalarials with melanin was studied. The dissociation constant for the drug-melanin complex and the relative number of binding sites on melanin were estimated for six of the drugs using a curve-fitting program. The reaction rate for the formation of the melanin-drug complex was determined, and the complexes were further characterized by zeta potential measurements.

  17. Dress codes and appearance policies: challenges under federal legislation, part 2: title VII of the civil rights act and gender.

    Science.gov (United States)

    Mitchell, Michael S; Koen, Clifford M; Darden, Stephen M

    2014-01-01

    As more and more individuals express themselves with tattoos and body piercings and push the envelope on what is deemed appropriate in the workplace, employers have an increased need for creation and enforcement of reasonable dress codes and appearance policies. As with any employment policy or practice, an appearance policy must be implemented and enforced without regard to an individual's race, color, gender, national origin, religion, disability, age, or other protected status. A policy governing dress and appearance based on the business needs of an employer that is applied fairly and consistently and does not have a disproportionate effect on any protected class will generally be upheld if challenged in court. By examining some of the more common legal challenges to dress codes and how courts have resolved the disputes, health care managers can avoid many potential problems. This article, the second part of a 3-part examination of dress codes and appearance policies, focuses on the issue of gender under the Civil Rights Act of 1964. Pertinent court cases that provide guidance for employers are addressed.

  18. Interpreting ASME limits and philosophy in FEA of pressure vessel parts

    International Nuclear Information System (INIS)

    Bezerra, L.M.; Cruz, J.R.B.; Miranda, C.A.J.; Neto, M.M.

    1995-01-01

    In recent years there has been an effort to interpret finite element (FE) stress results on the light of the ASME B and PV rules and philosophy. Many task groups have issued guidelines on stress linearization and classifications. All those attempts have come up trying to cope modern FE techniques with the rules imposed by the ASME Code. This paper is an independent contribution to the Pressure Vessel Research Council (PVRC) groups which are studying the stress classification and the failure mechanism in a FE framework. This work tries to complement the interesting work by Hollinger and Hechmer presented in the PVP-94 in Minneapolis. In that paper, the authors examined a typical support skirt and showed relations between the skirt collapse load obtained by finite element analysis and the loads allowed from the ASME stress limits. To complement such paper, in the present article, different skirt geometry configurations are analyzed. The configurations here investigated consist of similar support skirts but with different angles of attachments between cylinder and cone parts. It will be possible to observe the influence of the bending stress in the collapse load and its relation to the allowable loads inferred from the ASME limits. A pressure vessel with torispherical head under internal pressure is also examined. Using elastic and limit load FEA, the present paper determines the collapse loads of the configurations. It sets up the relations between these collapse loads, stress categories, and limits dictated by the ASME Code Subsection NB. On the light of NB rules and philosophy, this paper shows how different methods of stress assessment, classification, and limits may influence in the design of a pressure vessel

  19. Benchmark study of shear buckling of a cylindrical vessel. Part 2

    International Nuclear Information System (INIS)

    Combescure, A.; Bastien, R.; Carnoy, E.G.; Dostal, M.; Austin, N.M.; Peano, A.; Angeloni, P.

    1988-01-01

    In Liquid Metal Fast Breeder Reactors (LMFBR) potential shear buckling failures of the primary vessel, induced through seismic excitations, have to be considered. The primary vessel material, typically 316 stainless steel, has a low yield strength at the normal operating temperatures of around 400 0 C to 500 0 C. There characteristics tend to make the structure relatively flexible and subject to potential elasto-plastic shear buckling failure. The use of finite element techniques in buckling analyses is currently becoming more accepted. There are at present many finite element codes available which have the capacibility to solve buckling problems. The objective of the study reported herein was to follow on from the previous code validation exercise and investigate the ability of finite element codes to predict buckling behaviour in another test cylinder [a/h = 83, a/L = 1] where non-linear effects would be more significant and plastic shear buckling could be a failure mode. As before four organisations took part in the code validation exercise. NNC [UK] and ISMES [Italy] used the commercially available general purpose FE code ABAQUS. CEA [France] used INCA and BILBO which are members of the commercially available CASTEM suite of FE program. Novatome [France] used their in-house FE code NOVNL. The joint effort was co-ordinated by NNC with the assistance of the Commission of the European Communities Working on Codes and Standards AG2

  20. Elastic-plastic analysis of part-through crack propagation in piping and pressure vessels

    International Nuclear Information System (INIS)

    Souza, L.A. de; Ebecken, N.F.F.

    1986-01-01

    The shell structures, often used in the construction of reservoirs, pipings, pressure vessels, nuclear power plants, etc, with part-through crack along its thickness, are analysed, using a computer system developed by the finite element method. The surface is discretized with three-dimensional quadratic elements, degenerated in its mid-surface, such the fracture is simulated by scalar elements (non linear springs). The results are analysed by the stress intensity factor K Sub(I) and the strain energy release rate, which is known as J-integral. The analysis is performed in the elastic and elastic-plastic regime. The basic hipothesis and the formulation adopted in the derivation of the scalar elements are also shown. (Author) [pt

  1. Factor VII assay

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003676.htm Factor VII assay To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  2. Monoclonal antibodies to human factor VII: a one step immunoradiometric assay for VII:Ag.

    OpenAIRE

    Takase, T; Tuddenham, E G; Chand, S; Goodall, A H

    1988-01-01

    Three mouse monoclonal antibodies (RFF-VII/1, RFF-VII/2, and RFF-VII/3) which bind specifically to different epitopes on human factor VII antigen were raised. Two of the antibodies, RFF-VII/1 and RFF-VII/2, bound strongly to factor VII antigen (VII:Ag), but only RFF-VII/1 and RFF-VII/3 were potent inhibitors of factor VII coagulation activity (VII:C). RFF-VII/1 and RFF-VII/2 were used in a one step, double monoclonal immunoradiometric assay for VII:Ag. This was highly reproducible and detecte...

  3. Influence of shock waves as a result of assumed vessel failure on parts of the plant relevant to safety

    International Nuclear Information System (INIS)

    Danisch, R.; Graubner, U.

    1981-01-01

    The shock wave induced rupture is of subordinate importance for the laying out of the parts of the plant relevant to safety. It is covered by the precautions for maximum potential earthquakes, aircraft crashes and chemical explosions. The failure of vessels in the power house (WAZUe, SPWB) as the result of a maximum potential earthquake is extremely improbable. If a combination of the stresses resulting from maximum potential earthquakes with the hypothetical stresses resulting from vessel failure is undertaken, it can be seen that the total stresses are only increased by a minimal amount, due to the quadratic averaging of less than 3%. (orig./DG) [de

  4. Experimental modelling of core debris dispersion from the vault under a PWR pressure vessel: Part 1

    International Nuclear Information System (INIS)

    Macbeth, R.V.; Trenberth, R.

    1987-12-01

    Modelling experiments have been done on a 1/25 scale model in Perspex of the vault under a PWR pressure vessel. Various liquids have been used to simulate molten core debris assumed to have fallen on to the vault floor from a breach at the bottom of the pressure vessel. High pressure air and helium have been used to simulate the discharge of steam and gas from the breach. The dispersion of liquid via the vault access shafts has been measured. Photographs have been taken of fluid flow patterns and velocity profiles have been obtained. The requirements for further experiments are indicated. (author)

  5. External cooling: The SWR 1000 severe accident management strategy. Part 1: motivation, strategy, analysis: melt phase, vessel integrity during melt-water interaction

    International Nuclear Information System (INIS)

    Kolev, Nikolay Ivanov

    2004-01-01

    This paper provides the description of the basics behind design features for the severe accident management strategy of the SWR 1000. The hydrogen detonation/deflagration problem is avoided by containment inertization. In-vessel retention of molten core debris via water cooling of the external surface of the reactor vessel is the severe accident management concept of the SWR 1000 passive plant. During postulated bounding severe accidents, the accident management strategy is to flood the reactor cavity with Core Flooding Pool water and to submerge the reactor vessel, thus preventing vessel failure in the SWR 1000. Considerable safety margins have determined by using state of the art experiment and analysis: regarding (a) strength of the vessel during the melt relocation and its interaction with water; (b) the heat flux at the external vessel wall; (c) the structural resistance of the hot structures during the long term period. Ex-vessel events are prevented by preserving the integrity of the vessel and its penetrations and by assuring positive external pressure at the predominant part of the external vessel in the region of the molten corium pool. Part 1 describes the motivation for selecting this strategy, the general description of the strategy and the part of the analysis associated with the vessel integrity during the melt-water interaction. (author)

  6. Demonstration of an automated electromanometer for measurement of solution in accountability vessels in the Tokai Reprocessing Plant (part II)

    International Nuclear Information System (INIS)

    Yamonouchi, T.; Fukuari, Y.; Hayashi, M.; Komatsu, M.; Suyama, N.; Uchida, T.

    1982-01-01

    This report describes the results of an operational field test of the automated electromanometer system installed at the input accountability vessel (251V10) and the plutonium product accountability vessel (266V23) in the Tokai Reprocessing Plant. This system has been in use since September 1979 when it was installed in the PNC plant by BNL as part of Task-E, one of the thirteen tasks, in the Tokai Advanced Safeguards Technology Exercise (TASTEX) program. The first report on the progress of this task was published by S. Suda, et al., in the Proceedings of the INMM 22nd Annual Meeting. In this paper, further results of measurement and data analysis are shown. Also, the reliability and applicability of this instrument for accountability, safeguards, and process control purposes are investigated using the data of 106 batches for 251V10 and 40 batches for 266V23 obtained during two campaigns in 1981. There were small but significant differences relative to the plant's measurements for both vessels of 251V10 and 266V23; however, the difference for 251V10 was slightly decreased in the latest vessel calibration. Initially, there were many spurious signals originating with the raw data caused by a software error in the system. However, almost normal conditions were obtained after corrections of the program were made

  7. Intraoperative angiography in reconstructive vessel operations in the lower parts of the body

    International Nuclear Information System (INIS)

    Zehle, A.; Weinhold, C.H.; Hauger, W.

    1981-01-01

    The intraoperative angiography offers decisive advantages in reconstructive vessel operations, because this technique permits a direct and immediate examination of the obtained results and which thus can directly influence the technical and tactic management. Therefore this method allows in the most favourable case to improve prognosis. The technical realization and the procedure are facilitated by the combination of screening method and simple documentation, which is presented here. (orig./MG) [de

  8. Applications of energy-release-rate techniques to part-through cracks in experimental pressure vessels

    International Nuclear Information System (INIS)

    Bass, B.R.; Bryan, R.H.; Bryson, J.W.; Merkle, J.G.

    1982-01-01

    In nonlinear applications of computational fracture mechanics, energy release rate techniques are used increasingly for computing stress intensity parameters of crack configurations. Recently, deLorenzi used the virtual-crack-extension method to derive an analytical expression for the energy release rate that is better suited for three-dimensional calculations than the well-known J-integral. Certain studies of fracture phenomena, such as pressurized-thermal-shock of cracked structures, require that crack tip parameters be determined for combined thermal and mechanical loads. A method is proposed here that modifies the isothermal formulation of deLorenzi to account for thermal strains in cracked bodies. This combined thermo-mechanical formulation of the energy release rate is valid for general fracture, including nonplanar fracture, and applies to thermo-elastic as well as deformation plasticity material models. Two applications of the technique are described here. In the first, semi-elliptical surface cracks in an experimental test vessel are analyzed under elastic-plastic conditions using the finite element method. The second application is a thick-walled test vessel subjected to combined pressure and thermal shock loadings

  9. Estimation on the Flow Phenomena and the Pressure Loss for the Inlet Part of a Research Reactor Vessel

    International Nuclear Information System (INIS)

    Seo, Kyoung Woo; Oh, Jae Min; Seo, Jae Kwang; Yoon, Ju Hyeon; Lee, Doo Jeong

    2009-01-01

    For a research reactor, a conceptual primary cooling system (PCS) was designed for an adequate cooling to the reactor core. The developed primary cooling circuit consisted of decay tanks, pumps, heat exchangers, vacuum breakers, some isolation and check valves, connection piping, and instruments. The main function of the primary cooling pumps (PCPs) of the PCS was to circulate the reactor coolant through the fuel core and the heat exchangers during a normal operation. The head according to the design flow rate which was determined by the thermal hydraulic design analysis for the core should be estimated to design the PCPs in the fluid system. The pressure loss in the PCS can be calculated by the dimensional analysis of the pipe flow and the head loss coefficient of the components. However, it is insufficient to estimate the pressure loss for 3-dimensional flow phenomena such as the flow path in the reactor with the theoretical dimensional analysis based on experimental data. The purpose of this research is to evaluate the pressure loss of the part of a research reactor vessel. For evaluating the pressure loss, the commercially available CFD computer model, FLUENT, was employed. First, for validating the application of FLUENT to the pressure loss, a simple case was calculated and compared with the Idelchik empirical correlation. Secondly, several cases for the inlet part of a research reactor vessel were estimated by a FLUENT 3- dimensional calculation

  10. Genetics Home Reference: factor VII deficiency

    Science.gov (United States)

    ... Facebook Twitter Home Health Conditions Factor VII deficiency Factor VII deficiency Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Factor VII deficiency is a rare bleeding disorder that varies ...

  11. EKÜL VII Foorum = VII Forum SKTE / Sven Lillepalu

    Index Scriptorium Estoniae

    Lillepalu, Sven

    2004-01-01

    7. oktoobril toimus hotell Olümpia Alfa saalis EKÜL VII foorum. Ettekanded puudutasid järgmisi teemasid: korteriühistu remondi planeerimine, finantseerimine, nõuanded korteriühistuid puudutava seadusandluse kohta. Vt. samas: Eesti Korteriühistute VII Foorumi avalik pöördumine Eesti Vabariigi Valitsuse, Eesti Vabariigi Riigikogu, Eesti Vabariigi Presidendi poole lk. 9, 39

  12. Dress codes and appearance policies: challenges under federal legislation, part 3: Title VII, the Americans with Disabilities Act, and the National Labor Relations Act.

    Science.gov (United States)

    Mitchell, Michael S; Koen, Clifford M; Darden, Stephen M

    2014-01-01

    As more and more individuals express themselves with tattoos and body piercings and push the envelope on what is deemed appropriate in the workplace, employers have an increased need for creation and enforcement of reasonable dress codes and appearance policies. As with any employment policy or practice, an appearance policy must be implemented and enforced without regard to an individual's race, color, sex, national origin, religion, disability, age, or any other protected status. A policy governing dress and appearance based on the business needs of an employer that is applied fairly and consistently and does not have a disproportionate effect on any protected class will generally be upheld if challenged in court. By examining some of the more common legal challenges to dress codes and how courts have resolved the disputes, health care managers can avoid many potential problems. This article, the third part of a 3-part examination of dress codes and appearance policies, focuses on the issues of race and national origin under the Civil Rights Act, disability under the Americans With Disabilities Act, and employees' rights to engage in concerted activities under the National Labor Relations Act. Pertinent court cases that provide guidance for employers are addressed.

  13. Prediction and experimental verification of performance of box type solar cooker - Part I. Cooking vessel with central cylindrical cavity

    International Nuclear Information System (INIS)

    Reddy, Avala Raji; Rao, A.V. Narasimha

    2007-01-01

    The performance of conventional box type solar cookers can be improved by better designs of cooking vessels with proper understanding of the heat flow to the material to be cooked. An attempt has been made in this article to arrive at a mathematical model to understand the heat flow process to the cooking vessel and thereby to the food material. The mathematical model considers a double glazed hot box type solar cooker loaded with two different types of vessels, kept either on the floor of the cooker or on lugs. The performance of the cooking vessel with a central cylindrical cavity is compared with that of a conventional cylindrical cooking vessel. It is found from the experiments and modeling that the cooking vessel with a central cylindrical cavity on lugs results in a higher temperature of the thermic fluid than that of a conventional vessel on the floor or on lugs. The average improvement of performance of the vessel with a central cylindrical cavity kept on lugs is found to be 5.9% and 2.4% more than that of a conventional cylindrical vessel on the floor and on lugs, respectively

  14. Technical progress report on Wendelstein VII-AS

    International Nuclear Information System (INIS)

    Sapper, J.

    1985-01-01

    The modification of the WENDELSTEIN experiment at Garching into an advanced version with modular design was approved in 1982, after a planning time of one and a half year. The essential components /1,2/ of the new WENDELSTEIN VII-AS device are: - A modular field system instead of a helix and TF-system, consisting of 45 nonplanar coils. - A modular vacuum vessel, adapted to the coil system. - An additional TF-system for t-variation, consisting of 10 plane coils. - A structure shell for the modular field coils so that the vessel is free of coil forces

  15. Technology and Organisation of Inka Pottery Production in the Leche Valley. Part II: Study of Fired Vessels

    International Nuclear Information System (INIS)

    Hayashida, F.; Haeusler, W.; Riederer, J.; Wagner, U.

    2003-01-01

    Ceramic finds from the Inka workshops at Tambo Real and La Vina in the Leche Valley in northern Peru were studied by Moessbauer spectroscopy, thin section microscopy and X-ray diffraction. Sherds of Inka style vessels and of local style vessels can be distinguished by their shape, although local techniques appear to have been used in making both types. A reconstruction of the firing techniques by scientific studies of the ceramic material does not reveal a substantial difference in material or in the firing of both forms, although high firing temperatures were necessary to achieve sufficient stability of the large Inka style vessels. It cannot be decided whether the smaller local vessels were fired together with the Inka vessels or separately. Most of the variation in the maximum firing temperature can be explained with the normal temperature and atmosphere fluctuations in an open pit kiln.

  16. European Energy Law. Report VII

    Energy Technology Data Exchange (ETDEWEB)

    Hammer, U.; Roggenkamp, M.M. (eds.)

    2010-04-15

    The European Energy Law Report VII presents in four parts an overview of the most important legal developments in the field of EU and national energy and climate change law as discussed at the 2009 European Energy Law Seminar. The first part examines recent developments in EU climate change regulation. It includes an overview of the revision of the EU Directive governing CO2 emissions trading and a more detailed analysis of the new allocation regime, including the auctioning of emission rights. This is followed by an analysis of the competitiveness of the new EU emissions trading Directive and recent developments in the US regarding emissions trading. The second part focuses on the energy liberalisation process and the Third Energy Package. Following an overview of recent developments in EU competition law and the impact of the Sector Inquiry on the energy sector, this part concentrates particularly on the new Internal Energy Market Directives and most particularly on the legality of the unbundling provisions. Subsequently, the focus is on the role of the TSOs. After an analysis of the need for an increased cooperation of the German TSOs, another chapter discusses the need for more consolidation in the European gas transmission market and the role of regulation therein. Is there a new role for nuclear energy? In order to secure long term energy supply, the focus turns again to nuclear energy. The third part of this report discusses two elements of nuclear liability. First, it analyses the issue of the possible privatisation of the nuclear sector and its impact on long term liability. Although the focus is on the UK nuclear sector, a comparison is made with some other regulatory regimes. Next, the role of nuclear energy is discussed as an instrument to reduce CO2 emissions and, more particularly as a means to reach the 20-20-20 targets. The question is raised whether the international rules on civil liability provide sufficient protection to victims of nuclear

  17. 76 FR 57013 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Science.gov (United States)

    2011-09-15

    ... EQUAL EMPLOYMENT OPPORTUNITY COMMISSION 29 CFR Part 1602 RIN 3046-AA89 Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA AGENCY: Equal Employment Opportunity Commission. ACTION... under title VII, the ADA, and GINA. (76 FR 31892, June 2, 2011). No requests to present oral testimony...

  18. Dosimetry of VVER-1000 Reactor Pressure Vessel and Surveillance Specimens as a part of PLiM at Ukrainian NPPs

    International Nuclear Information System (INIS)

    Bukanov, V.N.; Diemokhin, V.L.; Grytsenko, O.V.; Ilkovych, V.V.; Pugach, A.M.; Pugach, S.M.; Vasylieva, O.G.; Vyshnevskyi, I.M.; Kasatkin, O.G.

    2012-01-01

    A regular surveillance program for VVER-1000 and its shortages are described. The Methodology for determination of neutron flux functionals on surveillance specimens of VVER-1000 pressure vessel is presented. The radiation exposure monitoring system for VVER-1000 pressure vessel is described. The main principles of an additional surveillance program for VVER-1000 are presented. The Dosimetry Experiment, which is already carrying out at Unit 3 of Rivne NPP, is described. (author)

  19. Positive association between increased popliteal artery vessel wall thickness and generalized osteoarthritis: is OA also part of the metabolic syndrome?

    International Nuclear Information System (INIS)

    Kornaat, Peter R.; Sharma, Ruby; Geest, Rob J. van der; Lamb, Hildo J.; Bloem, Johan L.; Watt, Iain; Kloppenburg, Margreet; Hellio le Graverand, Marie-Pierre

    2009-01-01

    The purpose of the study was to determine if a positive association exists between arterial vessel wall thickness and generalized osteoarthritis (OA). Our hypothesis is that generalized OA is another facet of the metabolic syndrome. The medical ethical review board of our institution approved the study. Written informed consent was obtained from each patient prior to the study. Magnetic resonance (MR) images of the knee were obtained in 42 patients who had been diagnosed with generalized OA at multiple joint sites. Another 27 MR images of the knee were obtained from a matched normal (non-OA) reference population. Vessel wall thickness of the popliteal artery was quantitatively measured by dedicated software. Linear regression models were used to investigate the association between vessel wall thickness and generalized OA. Adjustments were made for age, sex, and body mass index (BMI). Confidence intervals (CI) were computed at the 95% level and a significance level of α = 0.05 was used. Patients in the generalized OA population had a significant higher average vessel wall thickness than persons from the normal reference population (p ≤ α), even when correction was made for sex, age, and BMI. The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population. The association found between increased popliteal artery vessel wall thickness and generalized osteoarthritis suggests that generalized OA might be another facet of the metabolic syndrome. (orig.)

  20. Positive association between increased popliteal artery vessel wall thickness and generalized osteoarthritis: is OA also part of the metabolic syndrome?

    Energy Technology Data Exchange (ETDEWEB)

    Kornaat, Peter R.; Sharma, Ruby; Geest, Rob J. van der; Lamb, Hildo J.; Bloem, Johan L.; Watt, Iain [Leiden University Medical Center, Department of Radiology, Leiden (Netherlands); Kloppenburg, Margreet [Leiden University Medical Center, Department of Rheumatology, Leiden (Netherlands); Hellio le Graverand, Marie-Pierre [Pfizer Global Research and Development, New London, CT (United States)

    2009-12-15

    The purpose of the study was to determine if a positive association exists between arterial vessel wall thickness and generalized osteoarthritis (OA). Our hypothesis is that generalized OA is another facet of the metabolic syndrome. The medical ethical review board of our institution approved the study. Written informed consent was obtained from each patient prior to the study. Magnetic resonance (MR) images of the knee were obtained in 42 patients who had been diagnosed with generalized OA at multiple joint sites. Another 27 MR images of the knee were obtained from a matched normal (non-OA) reference population. Vessel wall thickness of the popliteal artery was quantitatively measured by dedicated software. Linear regression models were used to investigate the association between vessel wall thickness and generalized OA. Adjustments were made for age, sex, and body mass index (BMI). Confidence intervals (CI) were computed at the 95% level and a significance level of {alpha} = 0.05 was used. Patients in the generalized OA population had a significant higher average vessel wall thickness than persons from the normal reference population (p {<=} {alpha}), even when correction was made for sex, age, and BMI. The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population. The association found between increased popliteal artery vessel wall thickness and generalized osteoarthritis suggests that generalized OA might be another facet of the metabolic syndrome. (orig.)

  1. Vessel Operating Units (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains data for vessels that are greater than five net tons and have a current US Coast Guard documentation number. Beginning in1979, the NMFS...

  2. The Effect of Neonatal Gene Therapy on Skeletal Manifestations in Mucopolysaccharidosis VII Dogs after a Decade

    Science.gov (United States)

    Xing, Elizabeth M.; Knox, Van W.; O'Donnell, Patricia A.; Sikura, Tracey; Liu, Yuli; Wu, Susan; Casal, Margret L.; Haskins, Mark E.; Ponder, Katherine P.

    2013-01-01

    Mucopolysaccharidosis (MPS) VII is a lysosomal storage disease due to deficient activity of β-glucuronidase (GUSB), and results in glycosaminoglycan accumulation. Skeletal manifestations include bone dysplasia, degenerative joint disease, and growth retardation. One gene therapy approach for MPS VII involves neonatal intravenous injection of a gamma retroviral vector expressing GUSB, which results in stable expression in liver and secretion of enzyme into blood at levels predicted to be similar or higher to enzyme replacement therapy. The goal of this study was to evaluate the long-term effect of neonatal gene therapy on skeletal manifestations in MPS VII dogs. Treated MPS VII dogs could walk throughout their lives, while untreated MPS VII dogs could not stand beyond 6 months and were dead by 2 years. Luxation of the coxofemoral joint and the patella, dysplasia of the acetabulum and supracondylar ridge, deep erosions of the distal femur, and synovial hyperplasia were reduced, and the quality of articular bone was improved in treated dogs at 6 to 11 years of age compared with untreated MPS VII dogs at 2 years or less. However, treated dogs continued to have osteophyte formation, cartilage abnormalities, and an abnormal gait. Enzyme activity was found near synovial blood vessels, and there was 2% as much GUSB activity in synovial fluid as in serum. We conclude that neonatal gene therapy reduces skeletal abnormalities in MPS VII dogs, but clinically-relevant abnormalities remain. Enzyme replacement therapy will probably have similar limitations long-term. PMID:23628461

  3. Development of containers sealing system like part of surveillance program of the vessel in nuclear power plants

    International Nuclear Information System (INIS)

    Romero C, J.; Hernandez C, R.; Fernandez T, F.; Rocamontes A, M.; Perez R, N.

    2009-10-01

    The owners of nuclear power plants should be demonstrate that the embrittlement effects by neutronic radiation do not commit the structural integrity from the pressure vessel of nuclear reactors, during conditions of routine operation and below postulate accident. For this reason, there are surveillance programs of vessels of nuclear power plants, in which are present surveillance capsules. A surveillance capsule is compound by the support, six containers for test tubes and dosimeters. The containers for test tubes are of two types: rectangular container for test tubes, Charpy V and Cylindrical Container for tension test tubes. These test tubes are subject to a same or bigger neutronic flow to that of vessel, being representative of vessel mechanical conditions. The test tubes are rehearsed to watch over the increase of embrittlement that presents the vessel. This work describes the development of welding system to seal the containers for test tubes, these should be filled with helium of ultra high purity, to a pressure of an atmosphere. In this system the welding process Gas Tungsten Arc Welding is used, a hermetic camera that allows to place the containers with three grades of freedom, a vacuum subsystem and pressure, high technology equipment's like: power source with integrated computer, arc starter of high frequency, helium flow controller, among others. Finally, the advances in the inspection system for the qualification of sealing system are mentioned, system that should measure the internal pressure of containers and the helium purity inside these. (Author)

  4. Factor VII-activating protease

    DEFF Research Database (Denmark)

    Ramanathan, Ramshanker; Gram, Jørgen B; Sand, Niels Peter R

    2017-01-01

    : Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens...

  5. Monoclonal antibodies to human factor VII: production of immunodepleted plasma for VII:C assays.

    OpenAIRE

    Takase, T; Tuddenham, E G; Chand, S; Goodall, A H

    1988-01-01

    A high affinity monoclonal antibody to factor VII (RFF-VII/1), coupled to sepharose, was used to immunodeplete factor VII from normal plasma. The plasma could be used as a substrate in a one stage coagulation assay and performed as well as, or better than, commercially available factor VII deficient plasma or plasma from congenitally deficient factor VII patients. Plasma from normal donors (n = 20), patients with liver disease (n = 20), and patients receiving warfarin (n = 20), or congenitall...

  6. Experimental study of the effect of neutron radiation on pressurised water reactor vessel steel resilience - First part

    International Nuclear Information System (INIS)

    Verdeau, Jean-Jacques

    1969-12-01

    After having outlined the importance of the embrittlement of vessel steels by neutrons during the exploitation of pressurised water reactors, the author reports a set of tests which aimed at determining the effect of neutron irradiation on vessel steel resilience for operated, under construction or projected pressurized water reactors. He also tries to highlight the influence of irradiation temperature and of initial thermal treatments, and to look for a restoration thermal treatment of neutron-induced damages which could be applied to the considered vessels. Tests were performed on V Charpy resilience samples. Some samples have been irradiated by the Pile Department of the Grenoble CEN and then broken by the Laboratory of very high activity, whereas other samples have been irradiated in a prototype vessel and broken by a Cadarache department. The author presents characteristics of the studied steels (chemical compositions, thermal treatments), describes sample irradiation conditions, and the method of assessment of the transition temperature after irradiation, presents experimental results, discusses their interpretation, and presents future tests to be performed [fr

  7. A History of "Wasen" : Japanese-style Vessels : Part I: From Primitive Dugouts to Medieval Constructed Ships

    OpenAIRE

    T., Kosada; he University of Tokyo

    1980-01-01

    In 1975, the 484,337 dwt tanker Nissei Mam became the largest ship to be classified by NK. We know all of the details of this huge ship's construction, but what of those of its ancestry? This article explores the ancient history of the vessels that led up to this leviathan, and the unique manner in which "wasen", Japanese wooden ships, were developed.

  8. In- and ex-vessel flooding as part of the severe accident strategy in the KERENA reactor

    International Nuclear Information System (INIS)

    Levi, P.; Fischer, M.

    2011-01-01

    Currently, AREVA NP is finalizing the basic design of the KERENA reactor, an advanced boiling water reactor with a net electric output of about 1250 MWe. The safety concept in the KERENA reactor is founded on reliable active and passive systems for water supply and heat removal. The passive systems are based on simple physics and do not require operator action. Therefore, a severe accident (SA) with core damage, caused by the subsequent and multiple failures of the safety systems, has an extremely low probability. Despite this, the KERENA design is intended to involve measures that can limit and stop the progression of the severe accident which further reduces the frequency and extent of radioactive releases into the environment. These additional measures include in-vessel and ex-vessel flooding. Flooding is intended to remove the heat from the core or from the reactor pressure vessel (RPV) and transfer it into the containment. There the heat is removed by the active RHR (residual heat removal) system or by the passive CCCs (containment cooling condensers). Both flooding measures are passive and actuated independent of each other by different signals. The study shows that the in-vessel flooding is capable of arresting the core melt progression before a large molten pool can develop. In the unlikely event that the passive in-vessel flooding cannot be actuated or fails, the core will melt and relocate into the lower head of the RPV. In this case, as a further line of defense, decay heat removal can be achieved through the RPV wall into the water in the cavity. In order to assess whether the ex-vessel cooling can ensure RPV wall integrity a dedicated thermodynamics code has been developed which considers heat transfer from the molten corium pool into the RPV wall and the resulting wall ablation. As an input for the code the stratification behavior of the oxidic and metallic phase of the molten pool is examined. In the case of a light metallic phase on top, high heat

  9. Documentation of probabilistic fracture mechanics codes used for reactor pressure vessels subjected to pressurized thermal shock loading: Parts 1 and 2. Final report

    International Nuclear Information System (INIS)

    Balkey, K.; Witt, F.J.; Bishop, B.A.

    1995-06-01

    Significant attention has been focused on the issue of reactor vessel pressurized thermal shock (PTS) for many years. Pressurized thermal shock transient events are characterized by a rapid cooldown at potentially high pressure levels that could lead to a reactor vessel integrity concern for some pressurized water reactors. As a result of regulatory and industry efforts in the early 1980's, a probabilistic risk assessment methodology has been established to address this concern. Probabilistic fracture mechanics analyses are performed as part of this methodology to determine conditional probability of significant flaw extension for given pressurized thermal shock events. While recent industry efforts are underway to benchmark probabilistic fracture mechanics computer codes that are currently used by the nuclear industry, Part I of this report describes the comparison of two independent computer codes used at the time of the development of the original U.S. Nuclear Regulatory Commission (NRC) pressurized thermal shock rule. The work that was originally performed in 1982 and 1983 to compare the U.S. NRC - VISA and Westinghouse (W) - PFM computer codes has been documented and is provided in Part I of this report. Part II of this report describes the results of more recent industry efforts to benchmark PFM computer codes used by the nuclear industry. This study was conducted as part of the USNRC-EPRI Coordinated Research Program for reviewing the technical basis for pressurized thermal shock (PTS) analyses of the reactor pressure vessel. The work focused on the probabilistic fracture mechanics (PFM) analysis codes and methods used to perform the PTS calculations. An in-depth review of the methodologies was performed to verify the accuracy and adequacy of the various different codes. The review was structured around a series of benchmark sample problems to provide a specific context for discussion and examination of the fracture mechanics methodology

  10. Positivity VII (Zaanen Centennial Conference)

    CERN Document Server

    Pagter, Ben; Gaans, Onno; Veraar, Mark

    2016-01-01

    This book presents the proceedings of Positivity VII, held from 22-26 July 2013, in Leiden, the Netherlands. Positivity is the mathematical field concerned with ordered structures and their applications in the broadest sense of the word. A biyearly series of conferences is devoted to presenting the latest developments in this lively and growing discipline. The lectures at the conference covered a broad spectrum of topics, ranging from order-theoretic approaches to stochastic processes, positive solutions of evolution equations and positive operators on vector lattices, to order structures in the context of algebras of operators on Hilbert spaces. The contributions in the book reflect this variety and appeal to university researchers in functional analysis, operator theory, measure and integration theory and operator algebras. Positivity VII was also the Zaanen Centennial Conference to mark the 100th birth year of Adriaan Cornelis Zaanen, who held the chair of Analysis in Leiden for more than 25 years and was ...

  11. Sertula Florae Colombiae, VII

    Directory of Open Access Journals (Sweden)

    Uribe Uribe Lorenzo

    1964-06-01

    Full Text Available La preparación de un texto moderno que acompañe la publicación de las láminas de la Flora de la Real expedición Botánica del Nuevo Reino de Granada, ha hecho necesaria la recolección botánica intensiva, en las regiones que exploraron don JOSE CELESTINO MUTlS y sus compañeros.  Indispensable en algunos casos para la correcta interpretación de los icones, cuando los datos gráficos consignados por el artista son insuficientes para la determinación segura de la especie. Sólo el cotejo de la lámina con una planta viva y la posterior clasificación de ésta, ofrece seguridad en la determinación. Por otra parte, se logra así la proyección de nuestro trabajo actual en el ambiente y el medio en que se desarrolló el de Mutis y sus colaboradores.

  12. Photosynthetic pigments of oceanic Chlorophyta belonging to prasinophytes clade VII.

    Science.gov (United States)

    Lopes Dos Santos, Adriana; Gourvil, Priscillia; Rodríguez, Francisco; Garrido, José Luis; Vaulot, Daniel

    2016-02-01

    The ecological importance and diversity of pico/nanoplanktonic algae remains poorly studied in marine waters, in part because many are tiny and without distinctive morphological features. Amongst green algae, Mamiellophyceae such as Micromonas or Bathycoccus are dominant in coastal waters while prasinophytes clade VII, yet not formerly described, appear to be major players in open oceanic waters. The pigment composition of 14 strains representative of different subclades of clade VII was analyzed using a method that improves the separation of loroxanthin and neoxanthin. All the prasinophytes clade VII analyzed here showed a pigment composition similar to that previously reported for RCC287 corresponding to pigment group prasino-2A. However, we detected in addition astaxanthin for which it is the first report in prasinophytes. Among the strains analyzed, the pigment signature is qualitatively similar within subclades A and B. By contrast, RCC3402 from subclade C (Picocystis) lacks loroxanthin, astaxanthin, and antheraxanthin but contains alloxanthin, diatoxanthin, and monadoxanthin that are usually found in diatoms or cryptophytes. For subclades A and B, loroxanthin was lowest at highest light irradiance suggesting a light-harvesting role of this pigment in clade VII as in Tetraselmis. © 2015 Phycological Society of America.

  13. Resolution of the Task A-11 reactor-vessel materials-toughness safety issue. Part I. Main report. Part II. Staff responses to public comments, and Appendices A and B

    International Nuclear Information System (INIS)

    Johnson, R.

    1982-10-01

    This report provides the NRC position with respect to the reactor pressure vessel safety analysis required according to the rules given in the Code of Federal Regulations, Title 10 (10 CFR). An analysis is required whenever neutron irradiation reduces the Charpy V-notch upper shelf energy level in the vessel steel to 50 ft-lb or less. Task A-11 was needed because the available engineering methodology for such an analysis utilized linear elastic fracture mechanics principles, which could not fully account for the plastic deformation or stable crack extension expected at upper shelf temperatures. The Task A-11 goal was to develop an elastic-plastic fracture mechanics methodology, applicable to the beltline region of a pressurized water reactor vessel, which could be used in the required safety analysis. The goal was achieved with the help of a team of recognized experts. Part I of this volume contains the For Comment NUREG-0744, originally published in September 1981 and edited to accommodate comments from the public and the NRC staff. Edited segments are noted by vertical marginal lines. Part II of this volume contains the staff's responses to, and resolution of, the public comments received

  14. Genetics Home Reference: glycogen storage disease type VII

    Science.gov (United States)

    ... Home Health Conditions Glycogen storage disease type VII Glycogen storage disease type VII Printable PDF Open All ... Javascript to view the expand/collapse boxes. Description Glycogen storage disease type VII (GSDVII) is an inherited ...

  15. Revised VESCAL: Vessel calibration data analysis program. Improvement of a model for non-linear parts of annular and slab tanks

    International Nuclear Information System (INIS)

    Yanagisawa, Hiroshi

    1995-05-01

    For the purpose of the nuclear material accountancy and control for NUCEF: the Nuclear Fuel Cycle Safety Engineering Research Facility, the vessel calibration data analysis program: VESCAL is revised, and a new model for non-linear parts of annular and slab tanks is added to the program. The new model has three unknown parameters, and liquid level is expressed as a square root function with respect to liquid volume. Using the new model, an accurate calibration function on the level and volume data for non-linear parts of annular and slab tanks can be obtained with the smaller number of unknown parameters, compared with a polynomial function model. As a result of benchmark tests for this revision, it was proved that numerical results computed with VESCAL well agreed with those by a statistical analysis program package which is widely used. In addition, the new model would be useful for carrying out data analyses on the vessel calibration at the other bulk handling facilities as well as at NUCEF. This paper describes summary of the program, computational methods and results of benchmark tests concerning this revision. (author)

  16. Research vessels

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, P.S.

    The role of the research vessels as a tool for marine research and exploration is very important. Technical requirements of a suitable vessel and the laboratories needed on board are discussed. The history and the research work carried out...

  17. Analysis of ex-vessel melt jet breakup and coolability. Part 1: Sensitivity on model parameters and accident conditions

    Energy Technology Data Exchange (ETDEWEB)

    Moriyama, Kiyofumi; Park, Hyun Sun, E-mail: hejsunny@postech.ac.kr; Hwang, Byoungcheol; Jung, Woo Hyun

    2016-06-15

    Highlights: • Application of JASMINE code to melt jet breakup and coolability in APR1400 condition. • Coolability indexes for quasi steady state breakup and cooling process. • Typical case in complete breakup/solidification, film boiling quench not reached. • Significant impact of water depth and melt jet size; weak impact of model parameters. - Abstract: The breakup of a melt jet falling in a water pool and the coolability of the melt particles produced by such jet breakup are important phenomena in terms of the mitigation of severe accident consequences in light water reactors, because the molten and relocated core material is the primary heat source that governs the accident progression. We applied a modified version of the fuel–coolant interaction simulation code, JASMINE, developed at Japan Atomic Energy Agency (JAEA) to a plant scale simulation of melt jet breakup and cooling assuming an ex-vessel condition in the APR1400, a Korean advanced pressurized water reactor. Also, we examined the sensitivity on seven model parameters and five initial/boundary condition variables. The results showed that the melt cooling performance of a 6 m deep water pool in the reactor cavity is enough for removing the initial melt enthalpy for solidification, for a melt jet of 0.2 m initial diameter. The impacts of the model parameters were relatively weak and that of some of the initial/boundary condition variables, namely the water depth and melt jet diameter, were very strong. The present model indicated that a significant fraction of the melt jet is not broken up and forms a continuous melt pool on the containment floor in cases with a large melt jet diameter, 0.5 m, or a shallow water pool depth, ≤3 m.

  18. Completion of the fabrication and assembly of the internal parts and pressure vessel of the LABGENE reactor

    International Nuclear Information System (INIS)

    Guimaraes, Leonam dos Santos

    2005-01-01

    The Navy's Technological Center in Sao Paulo (CTMSP) has successfully concluded in 2005 the final assembly of the internals of the Laboratory of Energy Generation's Reactor (LABGENE). This structure together with the fuel elements and the control rods drives mechanisms are part of a PWR type Nuclear Reactor. (author)

  19. VVER-440 and VVER-1000 reactor dosimetry benchmark - BUGLE-96 versus ALPAN VII.0

    International Nuclear Information System (INIS)

    Duo, J. I.

    2011-01-01

    Document available in abstract form only, full text of document follows: Analytical results of the vodo-vodyanoi energetichesky reactor-(VVER-) 440 and VVER-1000 reactor dosimetry benchmarks developed from engineering mockups at the Nuclear Research Inst. Rez LR-0 reactor are discussed. These benchmarks provide accurate determination of radiation field parameters in the vicinity and over the thickness of the reactor pressure vessel. Measurements are compared to calculated results with two sets of tools: TORT discrete ordinates code and BUGLE-96 cross-section library versus the newly Westinghouse-developed RAPTOR-M3G and ALPAN VII.0. The parallel code RAPTOR-M3G enables detailed neutron distributions in energy and space in reduced computational time. ALPAN VII.0 cross-section library is based on ENDF/B-VII.0 and is designed for reactor dosimetry applications. It uses a unique broad group structure to enhance resolution in thermal-neutron-energy range compared to other analogous libraries. The comparison of fast neutron (E > 0.5 MeV) results shows good agreement (within 10%) between BUGLE-96 and ALPAN VII.O libraries. Furthermore, the results compare well with analogous results of participants of the REDOS program (2005). Finally, the analytical results for fast neutrons agree within 15% with the measurements, for most locations in all three mockups. In general, however, the analytical results underestimate the attenuation through the reactor pressure vessel thickness compared to the measurements. (authors)

  20. Wendelstein VII-A in torsatron mode

    International Nuclear Information System (INIS)

    Harmeyer, E.; Kisslinger, J.; Rau, F.; Wobig, H.

    1985-03-01

    Variable shear - positive or negative, up to about 20 percent - can be introduced into the Wendelstein VII-A Stellarator vacuum field configuration by different currents in the two helix systems, and balancing the resulting vertical field. (orig.)

  1. Mechanism of action of recombinant activated factor VII: an update.

    Science.gov (United States)

    Hedner, Ulla

    2006-01-01

    Bleeding episodes in patients with hemophilia and inhibitors must be managed using agents that are hemostatically active in the absence of factor VIII or IX. Activated prothrombin complex concentrates have long been used in this context. However, the search for safer and more effective agents has led to the development of recombinant activated factor VII (rFVIIa; NovoSeven, Novo Nordisk, Bagsvaerd, Denmark). This paper presents an update on the mechanism of action of rFVIIa, and describes how pharmacologic doses of this agent enhance thrombin production and thus contribute to the development of a stable, lysis-resistant fibrin plug at the site of vessel damage. This mechanism explains the reported efficacy of rFVIIa in a range of clinical situations characterized by impaired thrombin generation.

  2. Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy.

    Science.gov (United States)

    Hu, Zhiwei; Cheng, Jijun; Xu, Jie; Ruf, Wolfram; Lockwood, Charles J

    2017-02-01

    Identification of target molecules specific for angiogenic vascular endothelial cells (VEC), the inner layer of pathological neovasculature, is critical for discovery and development of neovascular-targeting therapy for angiogenesis-dependent human diseases, notably cancer, macular degeneration and endometriosis, in which vascular endothelial growth factor (VEGF) plays a central pathophysiological role. Using VEGF-stimulated vascular endothelial cells (VECs) isolated from microvessels, venous and arterial blood vessels as in vitro angiogenic models and unstimulated VECs as a quiescent VEC model, we examined the expression of tissue factor (TF), a membrane-bound receptor on the angiogenic VEC models compared with quiescent VEC controls. We found that TF is specifically expressed on angiogenic VECs in a time-dependent manner in microvessels, venous and arterial vessels. TF-targeted therapeutic agents, including factor VII (fVII)-IgG1 Fc and fVII-conjugated photosensitizer, can selectively bind angiogenic VECs, but not the quiescent VECs. Moreover, fVII-targeted photodynamic therapy can selectively and completely eradicate angiogenic VECs. We conclude that TF is an angiogenic-specific receptor and the target molecule for fVII-targeted therapeutics. This study supports clinical trials of TF-targeted therapeutics for the treatment of angiogenesis-dependent diseases such as cancer, macular degeneration and endometriosis.

  3. Extraction of Tc(VII) and Re(VII) on TRU resin

    Energy Technology Data Exchange (ETDEWEB)

    Guerin, Nicolas; Riopel, Remi; Kramer-Tremblay, Sheila [Canadian Nuclear Laboratories (CNL), Chalk River, ON (Canada). Radiobiology and Health Branch; De Silva, Nimal; Cornett, Jack [Ottawa Univ., ON (Canada). Dept. of Earth and Environmental Sciences; Dai, Xiongxin [China Institute for Radiation Protection, Beijing (China)

    2017-06-01

    TRU resin can be used to rapidly and selectively extract Tc(VII) and Re(VII). The retention capacity curves of Tc(VII) and Re(VII) for HNO{sub 3}, HCl, H{sub 2}SO{sub 4} and H{sub 3}PO{sub 4} solutions were studied and prepared. Tc(VII) and Re(VII) were simultaneously extracted in 2 M H{sub 2}SO{sub 4} and 1.5 M H{sub 3}PO{sub 4} and were effectively separated from Mo(VI) and Ru(III). Tc(VII) and Re(VII) remained strongly bonded to the resin even after washing using a large volume of 2 M H{sub 2}SO{sub 4} at a relatively high flow rate. Also, they were both completely eluted from the resin using 15 mL of near boiling water, an eluent directly compatible for ICP-MS instrument measurements.

  4. 33 CFR 155.1045 - Response plan requirements for vessels carrying oil as a secondary cargo.

    Science.gov (United States)

    2010-07-01

    ... PREVENTION REGULATIONS FOR VESSELS Tank Vessel Response Plans for Oil § 155.1045 Response plan requirements... actions. (4) The organizational structure that will be used to manage the response actions. This structure... with government agencies; (v) Spill response operations; (vi) Planning; (vii) Logistics support; and...

  5. Pressure vessel for nuclear reactor plant consisting of several pre-stressed cast pressure vessels

    International Nuclear Information System (INIS)

    Bodmann, E.

    1984-01-01

    Several cylindrical pressure vessel components made of pressure castings are arranged on a sector of a circle around the cylindrical cast pressure vessel for accommodating the helium cooled HTR. Each component pressure vessel is connected to the reactor vessel by a horizontal gas duct. The contact surfaces between reactor and component pressure vessel are in one plane. In the spaces between the individual component pressure vessels, there are supporting blocks made of cast iron, which are hollow and also have flat surfaces. With the reactor vessel and the component pressure vessels they form a disc-shaped connecting part below and above the gas ducts. (orig./PW)

  6. Modelling of the dynamics of the vessel and circuits of recirculation of a BWR type nucleo electric as part of the SUN-RAH university simulator

    International Nuclear Information System (INIS)

    Sanchez S, R.A.

    2003-01-01

    In the present project, the development of a model for the dynamics of the process of energy transport generated in the nuclear fuel until the main steam lines of a nucleo electric central with BWR type nuclear reactor, using mathematical models of reduced order is presented. These models present the main characteristics of the reactor vessel and of the recirculation system, defined by the main phenomena that intervene in those physical processes. Likewise, the objective of the general project of the one University student nucleo electric simulator with Boiling Water Reactor (SUN-RAH) for later on to establish the modeling equations for each part of the nuclear reactor as well as of the load pursuit system. Also, its were described the graphic interfaces implemented in an three layers architecture in which the different measuring variables are presented in the monitor. It fits signalize that the advantage presented by the University student nucleo electric simulator is the possibility to carry out changes in the magnitudes of those different variables that intervene in the physical processes made in the one reactor and in the recirculation system in execution time of the same one. Of same way, the creation of a graphic intuitive interface, friendly, and designed with the same technology with the one that the video games are programmed in the present time. Besides all the above mentioned, the pending goals inside of the project are exposed, as well as the developments in construction process or conceptualized to be included in future versions of the simulator. Finally its are thinking about possible scenarios of applications of SUN-RAH, as well as their reaches. (Author)

  7. 77 FR 64400 - Order of Succession for HUD Region VII

    Science.gov (United States)

    2012-10-19

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [FR-5550-D-10] Order of Succession for HUD Region VII... Offices (Region VII). This Order of Succession supersedes all previous Orders of Succession for HUD Region...). This publication supersedes all previous Orders of Succession for Region VII. Accordingly, the...

  8. Factors Influencing Title VII Bilingual Program Institutionalization.

    Science.gov (United States)

    Lewis, Gerald R.; And Others

    1985-01-01

    This study of the primary restraining and driving forces that influence Title VII bilingual education programs found the external environment, the local community, to be the main factor influencing institutionalization and self-renewal. The internal environment--the local school, and the local school's organization or central office, school board,…

  9. Dos Idiomas, Un Mundo. Dual Language Project. Title VII Biennial Evaluation Report, 1995-97.

    Science.gov (United States)

    Ernest, Harishini M.; Gonzalez, Rosa M.

    This is an evaluation of the first 2 years of a 5-year comprehensive Bilingual Education grant funded by Title VII Part A of the Improving America's Schools Act of 1994 in the Austin Independent School District (AISD) (Texas). The grant awarded to the AISD funds a program of Developmental Bilingual Education at two elementary schools where more…

  10. Containment vessel

    International Nuclear Information System (INIS)

    Zbirohowski-Koscia, K.F.; Roberts, A.C.

    1980-01-01

    A concrete containment vessel for nuclear reactors is disclosed that is spherical and that has prestressing tendons disposed in first, second and third sets, the tendons of each set being all substantially concentric and centred around a respective one of the three orthogonal axes of the sphere; the tendons of the first set being anchored at each end at a first anchor rib running around a circumference of the vessel, the tendons of the second set being anchored at each end at a second anchor rib running around a circumference of the sphere and disposed at 90 0 to the first rib, and the tendons of the third set being anchored some to the first rib and the remainder to the second rib. (author)

  11. Calculation of fluences of fast neutrons hitting the pressure vessel of the Dukovany NPP WWER-440 reactor. Part I. Theory, calculations, comparison with the experiment

    International Nuclear Information System (INIS)

    Rataj, J.

    1993-10-01

    The method of calculating neutron spectra and integral flux densities of neutrons hitting the pressure vessel of the Dukovany NPP WWER-440 reactor is outlined. The one-dimensional and two-dimensional calculations were performed by means of the DORT code in R, R-Z, and R-Θ geometries using the cross sections from the ELXSIR library. In the R-Θ geometry, the coupled neutron flux densities were determined. The calculated values of the maximum activation of detectors differ less than 15% from the values measured in surveillance specimens, which is within the limit of uncertainty associated with the position of the detector in the casing. The differences between the calculated and observed data behind the pressure vessel were below 4%. 10 tabs., 3 figs., 41 refs

  12. ENDF/B-VII.1 versus ENDF/B-VII.0: What's Different?

    International Nuclear Information System (INIS)

    Cullen, D.E.

    2012-01-01

    Recently the new ENDF/B-VII.1 library was released; this completely replaces the earlier ENDF/B-VII.0 library. One of the first questions we ask about a new library is: What's Different? Here I attempt to at least partially answer this question. I present results in both tabulated form (so you can quickly determine if any evaluations of interest to you have changed), and graphic form (so that you can see how much evaluations have changed and in what energy ranges). For the table I have compared what I refer to as the ENDF neutron data, namely MF=1 through 6. Here I did a character-by-character comparison of the same sections (MF/MT) that appear I both ENDF/B-VII.0 and VII.1; here I found differences in 170 evaluations. For the plots I have only compared the total cross sections for all evaluations that are common to both libraries, and I found that of the 423 evaluations in ENDF/B-VII.1, 120 of these have total cross sections that differ by 1% or more from the evaluation of the same isotope in ENDF/B-VII.0. This should be considered only a preliminary comparison; obviously there can be more subtle important differences that do not effect of total cross sections. Here I present plots comparing the total cross section of these 120 isotopes. The plots are only broad overviews of the total cross sections over their entire energy range. If you have interest in more detailed plots for specific evaluations, you can download the evaluations (1,2) and the PREPRO (3) codes I used to prepare and view the data. This is all I needed to do my comparisons, and is all you should need to do any more detailed comparisons to meet your individual needs.

  13. Development of containers sealing system like part of surveillance program of the vessel in nuclear power plants; Desarrollo del sistema de sellado de contenedores como parte del programa de vigilancia de la vasija en nucleoelectricas

    Energy Technology Data Exchange (ETDEWEB)

    Romero C, J.; Hernandez C, R.; Fernandez T, F.; Rocamontes A, M.; Perez R, N. [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)], e-mail: jesus.romero@inin.gob.mx

    2009-10-15

    The owners of nuclear power plants should be demonstrate that the embrittlement effects by neutronic radiation do not commit the structural integrity from the pressure vessel of nuclear reactors, during conditions of routine operation and below postulate accident. For this reason, there are surveillance programs of vessels of nuclear power plants, in which are present surveillance capsules. A surveillance capsule is compound by the support, six containers for test tubes and dosimeters. The containers for test tubes are of two types: rectangular container for test tubes, Charpy V and Cylindrical Container for tension test tubes. These test tubes are subject to a same or bigger neutronic flow to that of vessel, being representative of vessel mechanical conditions. The test tubes are rehearsed to watch over the increase of embrittlement that presents the vessel. This work describes the development of welding system to seal the containers for test tubes, these should be filled with helium of ultra high purity, to a pressure of an atmosphere. In this system the welding process Gas Tungsten Arc Welding is used, a hermetic camera that allows to place the containers with three grades of freedom, a vacuum subsystem and pressure, high technology equipment's like: power source with integrated computer, arc starter of high frequency, helium flow controller, among others. Finally, the advances in the inspection system for the qualification of sealing system are mentioned, system that should measure the internal pressure of containers and the helium purity inside these. (Author)

  14. Topics in Finance Part VII--Dividend Policy

    Science.gov (United States)

    Laux, Judy

    2011-01-01

    This series inspects the major topics in finance, reviewing the roles of stockholder wealth maximization, the risk-return tradeoff, and agency conflicts. The current article, devoted to dividend policy, also reviews the topic as presented in textbooks and the literature.

  15. Role of hepsin in factor VII activation in zebrafish.

    Science.gov (United States)

    Khandekar, Gauri; Jagadeeswaran, Pudur

    2014-01-01

    Factor VII, the initiator of the extrinsic coagulation cascade, circulates in human plasma mainly in its zymogen form, factor VII and in small amounts in its activated form, factor VIIa. However, the mechanism of initial generation of factor VIIa is not known despite intensive research using currently available model systems. Earlier findings suggested serine proteases factor VII activating protease and hepsin play a role in activating factor VII, however, it has remained controversial. In this paper we estimated the levels of factor VIIa and factor VII for the first time in zebrafish adult population and also reevaluated the role of the above two serine proteases in activating factor VII in vivo using zebrafish as a model system. Knockdown of factor VII activating protease and hepsin was performed followed by assaying for their effect on factor VIIa concentration and extrinsic coagulation as measured by the kinetic prothrombin time. Factor VII activating protease knockdown showed no change in kinetic prothrombin time and no effect on factor VIIa levels while hepsin knockdown increased the kinetic prothrombin time and significantly reduced the factor VIIa plasma levels. Our results thus indicate that hepsin plays a physiologically important role in factor VII activation and hemostasis in zebrafish. © 2013.

  16. Contribution to pressure vessels design of innovative methods and comparative application with standardized rules on a realistic structure – Part I

    International Nuclear Information System (INIS)

    Rohart, Philippe; Panier, Stéphane; Hariri, Saïd; Simonet, Yves; Afzali, Mansour

    2015-01-01

    Design of pressure vessels, which are subjected to various natures of loading, must prevent damage mechanisms occurrence. For a load applied or maintained with a given intensity, primary failure modes can appear, such as gross plastic deformation, plastic instability or buckling. For design-by-analysis, the reference methodology is based on an elastic stress calculation. During the last decade, studies have shown that this ingenious procedure could provide conservative design limits. They can become actually overly conservative in a context of increasing complexity of geometry and loading modelling. In parallel, technological and theoretical developments enabled limit analysis to be considered as an interesting design methodology. This is suggested in standards and codes (EN 13445, CODAP, Boiler and Pressure Vessels Code) since the early 2000"'"s. In this first of two companion papers, a set of standardized and innovative procedures is introduced. These approaches rely on various concepts, such as elasticity, incremental elastoplasticity, or elastic compensation (Modified Elastic Compensation Method, Linear Matching Method). Each methodology is presented on theoretical aspects, eventually adapted so as to take into account safety margins. They are then applied on a model inspired from a real industrial reactor, using Abaqus. Results are compared to reference data from codes, in terms of accuracy and computing time. A final assessment underlines practical benefits that could be expected. - Highlights: • A review of pressure vessels design methods against gross plastic deformation is made. • Innovative methodologies are introduced in order to overcome practical limits of classical methods. • Comparative tests are performed on one Benchmark with both classical and innovative procedures. • Results show the ability of innovative methodologies to improve the ratio ‘accuracy’ – ‘computationnal time’.

  17. Reactor vessel sealing plug

    International Nuclear Information System (INIS)

    Dooley, R.A.

    1986-01-01

    An apparatus is described for sealing a cold leg nozzle of a nuclear reactor pressure vessel from a remote location comprising: at least one sealing plug for mechanically sealing the nozzle from the inside of the reactor pressure vessel. The sealing plug includes a plate and a cone assembly having an end part receptive in the nozzle, the plate being axially moveable relative to the cone assembly. The plate and cone assembly have confronting bevelled edges defining an opening therebetween. A primary O-ring is disposed about the opening and is supported on the bevelled edges, the plate being guidably mounted to the cone assembly for movement toward the cone assembly to radially expand the primary O-ring into sealing engagement with the nozzle. A means is included for providing relative movement between the outer plate and the cone assembly

  18. A broad-group cross-section library based on ENDF/B-VII.0 for fast neutron dosimetry Applications

    Energy Technology Data Exchange (ETDEWEB)

    Alpan, F.A. [Westinghouse Electric Company, 1000 Westinghouse Drive, Cranberry Township, PA 16066 (United States)

    2011-07-01

    A new ENDF/B-VII.0-based coupled 44-neutron, 20-gamma-ray-group cross-section library was developed to investigate the latest evaluated nuclear data file (ENDF) ,in comparison to ENDF/B-VI.3 used in BUGLE-96, as well as to generate an objective-specific library. The objectives selected for this work consisted of dosimetry calculations for in-vessel and ex-vessel reactor locations, iron atom displacement calculations for reactor internals and pressure vessel, and {sup 58}Ni(n,{gamma}) calculation that is important for gas generation in the baffle plate. The new library was generated based on the contribution and point-wise cross-section-driven (CPXSD) methodology and was applied to one of the most widely used benchmarks, the Oak Ridge National Laboratory Pool Critical Assembly benchmark problem. In addition to the new library, BUGLE-96 and an ENDF/B-VII.0-based coupled 47-neutron, 20-gamma-ray-group cross-section library was generated and used with both SNLRML and IRDF dosimetry cross sections to compute reaction rates. All reaction rates computed by the multigroup libraries are within {+-} 20 % of measurement data and meet the U. S. Nuclear Regulatory Commission acceptance criterion for reactor vessel neutron exposure evaluations specified in Regulatory Guide 1.190. (authors)

  19. The pacemaker activity generating the intrinsic myogenic contraction of the dorsal vessel of Tenebrio molitor (Coleoptera).

    Science.gov (United States)

    Markou, T; Theophilidis, G

    2000-11-01

    Combined intracellular and extracellular recordings from various parts of the isolated dorsal vessel of Tenebrio molitor revealed some of the following electrophysiological properties of the heart and the aorta. (i) The wave of depolarization causing forward pulsation of the dorsal vessel was always transmitted from posterior to anterior, with a conduction velocity of 0.014 m s(-1) in the heart and 0.001 m s(-1) in the aorta when the heart rate was 60 beats min(-1). (ii) There was no pacemaker activity in the aorta. (iii) The duration of the compound action potential in the aortic muscle depended on the duration of the pacemaker action potential generated in the heart. (iv) Isolated parts of the heart continued to contract rhythmically for hours, indicating powerful pacemaker activity in individual cardiac segments. (v) There was a direct relationship between action potential duration and the length of the preceding diastolic interval. (vi) The rhythmic wave of depolarization was dependent on the influx of Ca(2+). (vii) The recovery of the electrical properties of myocardial cells that had been disrupted by sectioning was rapid. (viii) In hearts sectioned into two halves, the rhythmic pacemaker action potentials recorded simultaneously from the two isolated halves eventually drifted out of phase, but they had the same intrinsic frequency. In the light of these data, we discuss two alternative models for the generation of spontaneous rhythmic pumping movements of the heart and aorta.

  20. Frederik VII og folkets kærlighed

    DEFF Research Database (Denmark)

    Perlt, Michael; Vinding, Niels Valdemar

    2013-01-01

    I den turbulente tid mellem de to slesvigske krige drog kong Frederik VII under en rejse til Jylland i 1857 i procession op på højene i Jelling for at modtage folkets hyldest. På det historiske sted lod Frederik VII sig fejre som danskernes konge under en stor folkefest med bønder og deres familier...

  1. Two NEA sensitivity, 1-D benchmark calculations. Part I: Sensitivity of the dose rate at the outside of a PWR configuration and of the vessel damage

    International Nuclear Information System (INIS)

    Canali, U.; Gonano, G.; Nicks, R.

    1978-01-01

    Within the framework of the coordinated programme of sensitivity analysis studies, the reactor shielding benchmark calculation concerning the shield of a typical Pressurized Water Reactor, as proposed by I.K.E. (Stuttgart) and K.W.U. (Erlangen) has been performed. The direct and adjoint fluxes were calculated using ANISN, the cross-section sensitivity using SWANLAKE. The cross-section library used was EL4, 100 neutron + 19 gamma groups. The following quantities were of interest: neutron damage in the pressure vessel; dose rate outside the concrete shield. SWANLAKE was used to calculate the sensitivity of the above mentioned results to variations in the density of each nuclide present. The contributions of the different cross-section Legendre components are also given. Sensitivity profiles indicate the energy ranges in which a cross-section variation has a greater influence on the results. (author)

  2. Monoclonal anti-human factor VII antibodies. Detection in plasma of a second protein antigenically and genetically related to factor VII.

    OpenAIRE

    Broze, G J; Hickman, S; Miletich, J P

    1985-01-01

    Several murine monoclonal anti-human Factor VII antibodies were produced using hybridoma technology. Two noncompetitive monoclonal antibodies were used to examine by Western blotting the Factor VII cross-reactive material (CRM) in normal human plasma and three commercially available congenitally Factor VII-deficient plasmas, and to construct a facile "sandwich" immunoassay for plasma Factor VII. A second, previously undescribed, form of Factor VII CRM was detected in human plasma, which on We...

  3. Vessel Operator System

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Operator cards are required for any operator of a charter/party boat and or a commercial vessel (including carrier and processor vessels) issued a vessel permit from...

  4. Use of recombinant factor VII for tooth extractions in a patient with severe congenital factor VII deficiency: a case report.

    Science.gov (United States)

    Weinstock, Robert J; Onyejiuwa, Andrew; Shnayder, Garry; Clarkson, Earl I

    2015-04-01

    Patients with factor VII deficiency have an increased risk of prolonged perioperative hemorrhage. In this article, the authors present a case of severe factor VII deficiency in a patient who required tooth extraction. A 44-year-old woman with severe congenital factor VII deficiency sought care for a symptomatic, carious, and nonrestorable maxillary right second molar that required extraction. The authors obtained hematologic consultation, and the patient underwent the extraction under general anesthesia in the inpatient setting. Perioperative management included performing relevant laboratory studies, preoperative recombinant factor VII infusion, and postoperative intravenous aminocaproic acid administration. No hemorrhagic complications occurred throughout the perioperative course. The degree of factor VII deficiency correlates poorly with bleeding risk. Perioperative management is variable, requiring preoperative consultation with a hematologist. Copyright © 2015 American Dental Association. Published by Elsevier Inc. All rights reserved.

  5. Synergistic effect of factor VII gene polymorphisms causing mild factor VII deficiency in a case of severe factor X deficiency.

    Science.gov (United States)

    Deshpande, Rutuja; Ghosh, Kanjaksha; Shetty, Shrimati

    2017-01-01

    Congenital combined deficiency of coagulation factors VII and X are mainly attributed to large deletions involving both the genes in chromosome 13 or occasionally due to the coincidental occurrence of independently occurring mutations. We report the molecular basis of congenital combined deficiency of factors VII and X in a 6-year-old female child. Direct DNA sequencing of both factor VII (F7) and factor X (F10) genes showed a novel homozygous missense mutation p.Cys90Tyr (c.307G>A) in exon 4 of F10. No mutations were detected in F7; however, the patient was homozygous for three polymorphic alleles known to be associated with reduced factor VII levels. The present case illustrates the synergistic effect of multiple polymorphisms resulting in phenotypic factor VII deficiency in the absence of a pathogenic mutation.

  6. Current status of restoration work for obstacle and upper core structure in reactor vessel of experimental fast reactor 'JOYO'. Recovery of MARICO-2 sample part

    International Nuclear Information System (INIS)

    Ashida, Takashi; Ito, Hideaki

    2015-01-01

    At Joyo reactor MK-III core in May 2007, due to the design deficiencies of the disconnect mechanism of the holding part and the sample part of the experimental apparatus with instrumentation lines (MARICO-2), a disconnect failure incident occurred in the sample part after irradiation test. The deformation of the sample part due to this failure incurred its interference with the lower surface of reactor core upper structure and the holddown axis body. By this, the operating range of the rotary plug was restricted, leading to the partial inhibition of the fuel exchange function that precluded the access to 1/4 of the assemblies of the reactor core. In face of restoration work, the preparation for restoration such the exchange of upper core structure, and the recovery of MARICO-2 sample part are under way. The following items are introduced here: (1) summary of restoration work and overall process of restoration work, (2) recovery operation of MARICO-2 sample part, (3) exchange of the upper core structure that was conducted this year, and (4) results of recovery of MARIKO-2 sample part. (A.O.)

  7. Overview on W VII-X

    International Nuclear Information System (INIS)

    Wobig, H.

    1988-01-01

    Configurations for the W VII-X stellarator are reviewed. The MHD analysis of the Helias configuration with four field periods previously considered shows that the ballooning mode limit of the maximum plasma pressure increases with increasing number of field periods. Interest is focused on five-period Helias configurations with ballooning mode limits around a Beta factor of 5 %. Four configurations are discussed: HS4-12, an improved version of HS4-8; HS5-6, based on a quasi-helical equilibrium; plus two slightly different configurations designated as HS5-7 and HS5-8. It is proposed to increase the dimensions of the whole experiment to R=6.5m and to reduce the magnetic field to B=3T on the axis

  8. Japanese family with congenital factor VII deficiency.

    Science.gov (United States)

    Sakakibara, Kanae; Okayama, Yoshiki; Fukushima, Kenji; Kaji, Shunsaku; Muraoka, Michiko; Arao, Yujiro; Shimada, Akira

    2015-10-01

    Congenital factor VII (FVII) deficiency is a rare bleeding disorder with autosomal recessive inheritance. The present female patient was diagnosed with congenital FVII deficiency because of low hepaplastin test (HPT), although vitamin K was given. Heterozygous p.A191T mutation was detected in the peripheral blood, and the same mutation was also found in the mother and sister. To the best of our knowledge, this is the fourth reported case of p.A191T mutation of FVII in the literature and the first to be reported in Japan. FVII coagulation activity (FVII:C) in asymptomatic heterozygous carriers is mildly reduced. Therefore, some patients may not be accurately diagnosed with congenital FVII deficiency. In infants with low HPT without vitamin K deficiency, congenital FVII deficiency should be considered. © 2015 Japan Pediatric Society.

  9. Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect.

    Science.gov (United States)

    Mathijssen, Natascha C J; Masereeuw, Rosalinde; Holme, Pal Andre; van Kraaij, Marian G J; Laros-van Gorkom, Britta A P; Peyvandi, Flora; van Heerde, Waander L

    2013-08-01

    Prophylaxis with plasma-derived or recombinant activated factor VII is beneficial in severe factor VII deficiency. To understand why prophylactic treatment with both products is efficacious, we conducted a pharmacokinetic study. Ten factor VII deficient patients were treated with either recombinant activated (20 μg/kg) or plasma-derived (25 IU/kg) factor VII in a cross-over design. Pharmacokinetic parameters were analyzed through activated factor VII activity, factor VII clotting activity, and factor VII antigen levels on depicted time points. Factor VII activity half-lifes, determined by non-compartmental and one-compartmental analysis (results in brackets), were shorter for recombinant activated (1.4h; 0.7h) than for plasma-derived factor VII (6.8h; 3.2h); both recombinant activated (5.1h; 2.1h and plasma-derived factor VII (5.8h; 3.2h) resulted in longer half-lives of factor VII antigen. Activated factor VII half-lives (based on activated factor VII activity levels) were significantly higher compared to factor VII clotting activity (1.6h; 0.9h). Volumes of distribution were significantly higher for activated factor VII (236 ml/kg; 175 ml/kg, measured by activated factor VII) as compared to plasma-derived factor VII (206 ml/kg; 64 ml/kg, measured by factor FVII activity), suggesting a plasma- and extracellular fluid distribution for recombinant activated factor VII. Recombinant activated factor VII showed significantly shorter half-lifes than plasma-derived factor VII. Volumes of distribution were significantly higher for treatment with recombinant activated factor VII. The longer half-life for plasma-derived factor VII, compared to recombinant activated factor VII, and the increased volume of distribution for recombinant activated factor VII, compared to plasma-derived factor VII may further elucidate the beneficial effect of prophylactic treatment of both products. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Electrical discharge machining for vessel sample removal

    International Nuclear Information System (INIS)

    Litka, T.J.

    1993-01-01

    Due to aging-related problems or essential metallurgy information (plant-life extension or decommissioning) of nuclear plants, sample removal from vessels may be required as part of an examination. Vessel or cladding samples with cracks may be removed to determine the cause of cracking. Vessel weld samples may be removed to determine the weld metallurgy. In all cases, an engineering analysis must be done prior to sample removal to determine the vessel's integrity upon sample removal. Electrical discharge machining (EDM) is being used for in-vessel nuclear power plant vessel sampling. Machining operations in reactor coolant system (RCS) components must be accomplished while collecting machining chips that could cause damage if they become part of the flow stream. The debris from EDM is a fine talclike particulate (no chips), which can be collected by flushing and filtration

  11. Computerized reactor pressure vessel materials information system

    International Nuclear Information System (INIS)

    Strosnider, J.; Monserrate, C.; Kenworthy, L.D.; Tether, C.D.

    1980-10-01

    A computerized information system for storage and retrieval of reactor pressure vessel materials data was established, as part of Task Action Plan A-11, Reactor Vessel Materials Toughness. Data stored in the system are necessary for evaluating the resistance of reactor pressure vessels to flaw-induced fracture. This report includes (1) a description of the information system; (2) guidance on accessing the system; and (3) a user's manual for the system

  12. Acquired factor VII deficiency associated with acute myeloid leukemia.

    Science.gov (United States)

    Anoun, Soumaya; Lamchahab, Mouna; Oukkache, Bouchra; Qachouh, Maryam; Benchekroun, Said; Quessar, Asmaa

    2015-04-01

    Isolated acquired factor VII deficiency is a rare coagulopathy. It has been reported in 31 patients with malignancy, sepsis, postoperatively, aplastic anemia, and during bone marrow transplantation. We discuss, through a new case of acquired factor VII deficiency, the characteristics of this disease when it is associated with acute myeloid leukemia. Acquired factor VII deficiency in hematological diseases can be caused by intensive chemotherapy, infections, or hepatic dysfunction. The best treatment in developing countries remains corticosteroids associated with plasma exchange, frozen plasma, and antibiotics.

  13. Vasculite cutânea de pequenos vasos: etiologia, patogênese, classificação e critérios diagnósticos - Parte I Small vessel cutaneous vasculitis: etiology, pathogenesis, classification and diagnostic criteria - Part I

    Directory of Open Access Journals (Sweden)

    Hebert Roberto Clivati Brandt

    2007-10-01

    Full Text Available Vasculite é a inflamação da parede dos vasos. Pode variar em gravidade desde doença autolimitada de um único órgão até doença grave com risco de morte por falência de múltiplos órgãos. Existem várias causas, embora só se apresente por poucos padrões histológicos de inflamação vascular. Vasos de qualquer tipo e em qualquer órgão podem ser afetados, resultando em ampla variedade de sinais e sintomas. Diferentes vasculites com apresentações clínicas indistinguíveis têm evolução e tratamento muito diferentes. Essa condição representa desafio para o médico, incluindo classificação, diagnóstico, exames laboratoriais pertinentes, tratamento e seguimento adequado. Neste artigo são revistos a classificação, a etiologia, a patogênese e os critérios diagnósticos das vasculites cutâneas.Vasculitis is an inflammation of vessel walls. It may range in severity from a self-limited disorder in one single organ to a life-threatening disease due to multiple-organ failure. It has many causes, although they result in only a few histological patterns of vascular inflammation. Vessels of any type in any organ can be affected, a fact that results in a broad variety of signs and symptoms. Different vasculitides with indistinguishable clinical presentations have very different prognosis and treatments. This condition presents many challenges to physicians in terms of classification, diagnosis, appropriate laboratory workup, treatment, and the need for careful follow-up. This article reviews the classification, etiology, pathology and diagnostic criteria of cutaneous vasculitis.

  14. A rare combination: congenital factor VII deficiency with Chiari malformation.

    Science.gov (United States)

    Bay, Ali; Aktekin, Elif; Erkutlu, Ibrahim

    2015-12-01

    Congenital factor (VII) deficiency is a rare bleeding disorder. We present a patient with congenital FVII deficiency and congenital hydrocephalus who underwent a ventriculoperitoneal shunt operation and needed no prophylaxis after the procedure.

  15. TEH võrgustik - viis aastat Eestis / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2005-01-01

    Eestis on tervist edendavate haiglate (TEH) võrgustik tegutsenud juba viis aastat, sellega on liitunud 22 haiglat. Tänavust konverentsi peeti teemal "Tervise edendamine ja kvaliteedi tagamine haiglas: standardid ja praktika"

  16. New Neutron, Proton, and S(α,β) MCNP Data Libraries Based on ENDF/B-VII

    International Nuclear Information System (INIS)

    Little, Robert C.; Trellue, Holly R.; MacFarlane, Robert E.; Kahler, A.C.; Lee, Mary Beth; White, Morgan C.

    2008-01-01

    The general-purpose Evaluated Nuclear Data File ENDF/B-VII.0 was released in December 2006. A number of sub-libraries were included in ENDF/B-VII.0 such that data were provided for incident neutrons, photons, and charged particles. This paper describes the creation of MCNP data libraries at Los Alamos National Laboratory based on three ENDF/B-VII.0 sub-libraries: neutrons, protons, and thermal scattering. An ACE-formatted continuous-energy neutron data library called ENDF70 for MCNP has been produced. This library provides data for 390 materials at five temperatures: 293.6, 600, 900, 1200, and 2500 K. The library was processed primarily with Version 248 of NJOY99. Extensive checking and quality-assurance tests were applied to the data. Improvements to the processing code were made and certain evaluations were modified as a result of these tests. ENDF/B-VII.0 included proton evaluations for 48 target materials. Forty-seven proton evaluations (all except for 13 C) were processed at room temperature and combined into the MCNP library ENDF70PROT. Neutron thermal S(α,β) scattering data exist for twenty different materials in ENDF/B-VII.0. All twenty of these evaluations were processed at all applicable temperatures (these vary for each evaluation), and combined into the MCNP library ENDF70SAB. All of these ENDF/B-VII.0 based MCNP libraries (ENDF70, ENDF70PROT, and ENDF70SAB) are available as part of the MCNP5 1.50 release. (authors)

  17. Nuclear reactor with a suspended vessel

    International Nuclear Information System (INIS)

    Lemercier, Guy.

    1977-01-01

    This invention relates to a nuclear reactor with a suspended vessel and applies in particular when this is a fast reactor, the core or active part of the reactor being inside the vessel and immersed under a suitable volume of flowing liquid metal to cool it by extracting the calories released by the nuclear fission in the fuel assemblies forming this core [fr

  18. Fabrication of Separator Demonstration Facility process vessel

    International Nuclear Information System (INIS)

    Oberst, E.F.

    1985-01-01

    The process vessel system is the central element in the Separator Development Facility (SDF). It houses the two major process components, i.e., the laser-beam folding optics and the separators pods. This major subsystem is the critical-path procurement for the SDF project. Details of the vaious parts of the process vessel are given

  19. Ultrasound periodic inspections of reactor pressure vessels

    International Nuclear Information System (INIS)

    Haniger, L.

    1980-01-01

    Two versions are described of ultrasonic equipment for periodic inspections of reactor pressure vessels. One uses the principle of exchangeable programmators with solid-state logic while the other uses programmable logic with semiconductor memories. The equipment is to be used for inspections of welded joints on the upper part of the V-1 reactor pressure vessel. (L.O.)

  20. Basic Electricity. Part 3.

    Science.gov (United States)

    Kilmer, Donald C.

    Third (part 3) in a set of four guides designed for the student interested in a vocation in electrical work, this guide includes four units: Unit VI--Ohm's Law, covering six lessons (voltage, current-flow and resistance, the Ohm's Law formula, formula for finding voltage, formula for finding resistance); Unit VII--Voltages, covering five lessons…

  1. Faktor-faktor Yang Memengaruhi Produksi Gula PTPN VII (Persero)

    OpenAIRE

    Savitri, Rizky; Widyastutik, Widyastutik

    2013-01-01

    This study aimed to analyze the influence of the level of sugar cane yield, labor, production process period, and supporting materials on the production of PTPN VII (Persero) PG. Cinta Manis, as well as analyzing the elasticity of production and business scale of PTPN VII (Persero) PG. Cinta Manis. The method used to analyze the data were quantitative analysis of Cobb Douglas production function with ordinary least square method to observe variable influences of PG. Cinta Manis sugar product...

  2. Preparation of factor VII concentrate using CNBr-activated Sepharose 4B immunoaffinity chromatography

    OpenAIRE

    Mousavi Hosseini, Kamran; Nasiri, Saleh

    2015-01-01

    Background: Factor VII concentrates are used in patients with congenital or acquired factor VII deficiency or treatment of hemophilia patients with inhibitors. In this research, immunoaffinity chromatography was used to purify factor VII from prothrombin complex (Prothrombin- Proconvertin-Stuart Factor-Antihemophilic Factor B or PPSB) which contains coagulation factors II, VII, IX and X. The aim of this study was to improve purity, safety and tolerability as a highly purified factor VII conce...

  3. Multiple shell pressure vessel

    International Nuclear Information System (INIS)

    Wedellsborg, B.W.

    1988-01-01

    A method is described of fabricating a pressure vessel comprising the steps of: attaching a first inner pressure vessel having means defining inlet and outlet openings to a top flange, placing a second inner pressure vessel, having means defining inlet and outlet opening, concentric with and spaced about the first inner pressure vessel and attaching the second inner pressure vessel to the top flange, placing an outer pressure vessel, having inlet and outlet openings, concentric with and spaced apart about the second inner pressure vessel and attaching the outer pressure vessel to the top flange, attaching a generally cylindrical inner inlet conduit and a generally cylindrical inner outlet conduit respectively to the inlet and outlet openings in the first inner pressure vessel, attaching a generally cylindrical outer inlet conduit and a generally cylindrical outer outlet conduit respectively to the inlet and outlet opening in the second inner pressure vessel, heating the assembled pressure vessel to a temperature above the melting point of a material selected from the group, lead, tin, antimony, bismuth, potassium, sodium, boron and mixtures thereof, filling the space between the first inner pressure vessel and the second inner pressure vessel with material selected from the group, filling the space between the second inner pressure vessel and the outer pressure vessel with material selected from the group, and pressurizing the material filling the spaces between the pressure vessels to a predetermined pressure, the step comprising: pressurizing the spaces to a pressure whereby the wall of the first inner pressure vessel is maintained in compression during steady state operation of the pressure vessel

  4. Vessel dilatation in coronary angiograms

    International Nuclear Information System (INIS)

    Hinterauer, L.; Goebel, N.

    1983-01-01

    Amongst 166 patients with aneurysms, ectasia or megaloarteries shown on coronary angiograms, 86.1% had dilated vessels as part of generalised coronary sclerosis (usually in patients with three-vessel disease). In 9%, dilatation was of iatrogenic origin and in 4.8% it was idiopathic. One patient had Marfan's syndrome. Amongst 9 000 patients, there were eight with megalo-arteries without stenosis; six of these had atypical angina and three suffered an infarct. Patients with definite dilatation of the coronary artery and stagnation of contrast flow required treatment. (orig.) [de

  5. Vessel dilatation in coronary angiograms

    Energy Technology Data Exchange (ETDEWEB)

    Hinterauer, L.; Goebel, N.

    1983-11-01

    Amongst 166 patients with aneurysms, ectasia or megaloarteries shown on coronary angiograms, 86.1% had dilated vessels as part of generalised coronary sclerosis (usually in patients with three-vessel disease). In 9%, dilatation was of iatrogenic origin and in 4.8% it was idiopathic. One patient had Marfan's syndrome. Amongst 9 000 patients, there were eight with megalo-arteries without stenosis; six of these had atypical angina and three suffered an infarct. Patients with definite dilatation of the coronary artery and stagnation of contrast flow required treatment.

  6. Separation of Rhenium (VII) from Tungsten (VI)

    International Nuclear Information System (INIS)

    Vucina, J.; Lukic, D.; Stoiljkovic, M.; Milosevic, M.; Orlic, M.

    2004-01-01

    Examined were the conditions for an effective separation of tungsten (VI) and rhenium (VII) on alumina if the solution of 0.20 mol dm -3 NaCl, ph=2.6 is used as the aqueous phase. Under the given experimental conditions alumina was found to be much better adsorbent for tungsten than for rhenium. The breakthrough and saturation capacities of alumina at pH=2 are 24 and 78 mg W/g Al 2 O 3 , respectively. With the increase of pH these values decrease. So, at pH=6 they are only 4 and 13 mg W/g Al 2 O 3 respectively. The elution volume for rhenium for the given column dimensions and quantity of the adsorbent is about 16 ml. These results were confirmed by the experiments of the radiological separations. Tungsten-187 remains firmly bound to the alumina. The radionuclide purity of the eluted 186'188 Re at pH=2 is very high. (authors)

  7. Pressurized wet digestion in open vessels (T11)

    International Nuclear Information System (INIS)

    Kettisch, P.; Maichin, P.; Zischka, M.; Knapp, G.

    2002-01-01

    Full text: Pressurized wet digestion in closed vessels, microwave assisted or with conventional conductive heating, is the most important sample preparation technique for digestion or leaching procedures in element analysis. In comparison to open vessel digestion closed vessel digestion methods have many advantages, but there is one disadvantage - complex and expensive vessel designs. A new technique - pressurized wet digestion in open vessels - combine the advantages of closed vessel sample digestion with the application of simple and cheap open vessels made of quartz or PFA. The vessels are placed in a high pressure Asher HPA, which is adapted with a Teflon liner and filled partly with water. The analytical results with 30 ml quartz vessels, 22 ml PFA vessels and 1.5 ml PIA auto sampler cups will be shown. In principle every dimensions of vessels can be used. The vessels are loaded with sample material (max. 1.5 g with quartz vessels, max. 0.5 g with PFA vessels and 50 mg with auto sampler cups) and digestion reagent. Afterwards the vessels are simply covered with PTFE stoppers and not sealed. The vessels are transferred into a special adapted HPA and digested at temperatures up to 270 o C. The digestion time is 90 min. and cooling down to room temperature 30 min. The analytical results of CRM's are within the certified values and no cross contamination and losses of volatile elements could be observed. (author)

  8. Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect

    NARCIS (Netherlands)

    Mathijssen, N.C.J.; Masereeuw, R.; Holme, P.A.; Kraaij, M.G.J. van; Laros, B.A.P.; Peyvandi, F.; Heerde, W.L. van

    2013-01-01

    INTRODUCTION: Prophylaxis with plasma-derived or recombinant activated factor VII is beneficial in severe factor VII deficiency. To understand why prophylactic treatment with both products is efficacious, we conducted a pharmacokinetic study. MATERIALS AND METHODS: Ten factor VII deficient patients

  9. Neutral transport calculations for W VII-X. First applications to W VII-X

    International Nuclear Information System (INIS)

    Sardei, F.

    1988-01-01

    Results of neutral gas transport calculations obtained with the DEGAS code are presented for a W VII-AS model plasma and a source of neutrals due to limiter recycling. For typical profiles of the plasma parameters as predicted for an ECRH discharge, the simulation yields a radial drop of the average neutral population by a factor of 30. The neutrals are strongly localized near the limiter and have a poloidal minimum at its opposite side. For a W VII-X configuration (HS4-12), a neutral source given by a high recycling ion flux equally distributed over the wall is considered. For an ion density of 5 x 10 1 3 /cc and 30 eV edge temperature, the neutrals originating from the wall completely ionize within the ergodic region. The corresponding average energy of cx neutrals hitting the wall is less than 30 eV. Neutral penetration into the plasma locally depends on the distance between wall and separatrix

  10. Probabilistic retinal vessel segmentation

    Science.gov (United States)

    Wu, Chang-Hua; Agam, Gady

    2007-03-01

    Optic fundus assessment is widely used for diagnosing vascular and non-vascular pathology. Inspection of the retinal vasculature may reveal hypertension, diabetes, arteriosclerosis, cardiovascular disease and stroke. Due to various imaging conditions retinal images may be degraded. Consequently, the enhancement of such images and vessels in them is an important task with direct clinical applications. We propose a novel technique for vessel enhancement in retinal images that is capable of enhancing vessel junctions in addition to linear vessel segments. This is an extension of vessel filters we have previously developed for vessel enhancement in thoracic CT scans. The proposed approach is based on probabilistic models which can discern vessels and junctions. Evaluation shows the proposed filter is better than several known techniques and is comparable to the state of the art when evaluated on a standard dataset. A ridge-based vessel tracking process is applied on the enhanced image to demonstrate the effectiveness of the enhancement filter.

  11. 75 FR 56015 - Vessel Inspection Alternatives

    Science.gov (United States)

    2010-09-15

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 46 CFR Part 8 Vessel Inspection Alternatives CFR... Certificate; (ii) International Tonnage Certificate; (iii) Cargo Ship Safety Construction Certificate; (iv) Cargo Ship Safety Equipment Certificate; and (v) International Oil Pollution Prevention Certificate; and...

  12. Improvement to reactor vessel

    International Nuclear Information System (INIS)

    1974-01-01

    The vessel described includes a prestressed concrete vessel containing a chamber and a removable cover closing this chamber. The cover is in concrete and is kept in its closed position by main and auxiliary retainers, comprising fittings integral with the concrete of the vessel. The auxiliary retainers pass through the concrete of the cover. This improvement may be applied to BWR, PWR and LMFBR type reactor vessel [fr

  13. Benchmarking ENDF/B-VII.0

    International Nuclear Information System (INIS)

    Marck, Steven C. van der

    2006-01-01

    The new major release VII.0 of the ENDF/B nuclear data library has been tested extensively using benchmark calculations. These were based upon MCNP-4C3 continuous-energy Monte Carlo neutronics simulations, together with nuclear data processed using the code NJOY. Three types of benchmarks were used, viz., criticality safety benchmarks (fusion) shielding benchmarks, and reference systems for which the effective delayed neutron fraction is reported. For criticality safety, more than 700 benchmarks from the International Handbook of Criticality Safety Benchmark Experiments were used. Benchmarks from all categories were used, ranging from low-enriched uranium, compound fuel, thermal spectrum ones (LEU-COMP-THERM), to mixed uranium-plutonium, metallic fuel, fast spectrum ones (MIX-MET-FAST). For fusion shielding many benchmarks were based on IAEA specifications for the Oktavian experiments (for Al, Co, Cr, Cu, LiF, Mn, Mo, Si, Ti, W, Zr), Fusion Neutronics Source in Japan (for Be, C, N, O, Fe, Pb), and Pulsed Sphere experiments at Lawrence Livermore National Laboratory (for 6 Li, 7 Li, Be, C, N, O, Mg, Al, Ti, Fe, Pb, D 2 O, H 2 O, concrete, polyethylene and teflon). For testing delayed neutron data more than thirty measurements in widely varying systems were used. Among these were measurements in the Tank Critical Assembly (TCA in Japan) and IPEN/MB-01 (Brazil), both with a thermal spectrum, and two cores in Masurca (France) and three cores in the Fast Critical Assembly (FCA, Japan), all with fast spectra. In criticality safety, many benchmarks were chosen from the category with a thermal spectrum, low-enriched uranium, compound fuel (LEU-COMP-THERM), because this is typical of most current-day reactors, and because these benchmarks were previously underpredicted by as much as 0.5% by most nuclear data libraries (such as ENDF/B-VI.8, JEFF-3.0). The calculated results presented here show that this underprediction is no longer there for ENDF/B-VII.0. The average over 257

  14. ALICE HMPID Radiator Vessel

    CERN Document Server

    2003-01-01

    View of the radiator vessels of the ALICE/HMPID mounted on the support frame. Each HMPID module is equipped with 3 indipendent radiator vessels made out of neoceram and fused silica (quartz) windows glued together. The spacers inside the vessel are needed to stand the hydrostatic pressure. http://alice-hmpid.web.cern.ch/alice-hmpid

  15. Age-related changes in factor VII proteolysis in vivo.

    Science.gov (United States)

    Ofosu, F A; Craven, S; Dewar, L; Anvari, N; Andrew, M; Blajchman, M A

    1996-08-01

    Previous studies have reported that pre-operative plasmas of patients over the age of 40 years who developed post-operative deep vein thrombosis (DVT) had approximately twice the amount of proteolysed factor VII found in plasmas of patients in whom prophylaxis with heparin or low M(r) heparin was successful. These and other studies also reported higher concentrations of thrombin-antithrombin III in pre- and post-operative plasmas of patients who developed post-operative thrombosis than in plasmas of patients in whom prophylaxis was successful. Whether the extent of factor VII proteolysis seen in the patients who developed post-operative DVT is related to the severity of their disease or age is not known. This report investigated age-related changes in the concentrations of total factor VII protein, factor VII zymogen, factor VIIa, tissue factor pathway inhibitor, thrombin-antithrombin III, and prothrombin fragment 1 + 2 in normal plasmas and the relationships between these parameters. With the exception of thrombin-antithrombin III, statistically significant increases in the concentrations of these parameters with age were found. Additionally, the differences between the concentrations of total factor VII protein and factor VII zymogen, an index factor VII proteolysis in vivo, were statistically significant only for individuals over age 40. Using linear regression analysis, a significant correlation was found to exist between the concentrations of plasma factor VIIa and prothrombin fragment 1 + 2. Since factor VIIa-tissue factor probably initiates coagulation in vivo, we hypothesize that the elevated plasma factor VIIa (reflecting a less tightly regulated tissue factor activity and therefore increased thrombin production in vivo) accounts for the high risk for post-operative thrombosis seen in individuals over the age of 40.

  16. Newly diagnosed congenital factor VII deficiency and utilization of recombinant activated factor VII (NovoSeven(®)).

    Science.gov (United States)

    Bartosh, Nicole S; Tomlin, Tara; Cable, Christian; Halka, Kathleen

    2013-01-01

    This case report presents a newly diagnosed congenital factor VII deficiency treated with recombinant activated factor VII (rFVIIa). Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder that occurs in fewer than 1/500,000 persons. Its presentation can vary from epistaxis to hemarthroses and severe central nervous system bleeding, and correlates poorly with factor VII levels. Our patient had not had a significant hemostatic challenge prior to his presentation and therefore never had any symptomatology suggestive of this disease. He was treated with rFVIIa, and was able to undergo repair of his fractures without bleeding. A 19-year-old African-American male presented to the emergency room after an altercation that resulted in significant trauma. He sustained bilateral mandibular angle fractures and orbital floor fractures, requiring urgent surgical correction. On initial evaluation, he was noted to have a prolonged prothrombin time of 40.1 seconds, with an International Normalized Ratio of 4.0, a normal activated partial thromboplastin time of 29.9 seconds, and a platelet count of 241. After receiving vitamin K and fresh frozen plasma, he was taken to the operating room for a temporary rigid maxillomandibular fixation. A 1:1 mixing study with normal plasma corrected the prothrombin time (decreasing from 40.7 to 14.7 seconds) and a factor VII assay revealed 5% of the normal factor VII level. The patient was diagnosed with congenital factor VII deficiency. Due to his coagulopathy and the extensive surgical correction needed, rFVIIa was administered and surgery was accomplished without hemorrhagic sequelae. This case report and review describes a rare congenital disease, the history of rFVIIa use, and its mechanism. rFVIIA use in our patient provided a treatment option that allowed the necessary surgical correction, but further prospective studies on dose optimization would ensure adequate dosing with minimal risk of severe side effects.

  17. Newly diagnosed congenital factor VII deficiency and utilization of recombinant activated factor VII (NovoSeven®)

    Science.gov (United States)

    Bartosh, Nicole S; Tomlin, Tara; Cable, Christian; Halka, Kathleen

    2013-01-01

    This case report presents a newly diagnosed congenital factor VII deficiency treated with recombinant activated factor VII (rFVIIa). Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder that occurs in fewer than 1/500,000 persons. Its presentation can vary from epistaxis to hemarthroses and severe central nervous system bleeding, and correlates poorly with factor VII levels. Our patient had not had a significant hemostatic challenge prior to his presentation and therefore never had any symptomatology suggestive of this disease. He was treated with rFVIIa, and was able to undergo repair of his fractures without bleeding. Case report A 19-year-old African-American male presented to the emergency room after an altercation that resulted in significant trauma. He sustained bilateral mandibular angle fractures and orbital floor fractures, requiring urgent surgical correction. On initial evaluation, he was noted to have a prolonged prothrombin time of 40.1 seconds, with an International Normalized Ratio of 4.0, a normal activated partial thromboplastin time of 29.9 seconds, and a platelet count of 241. After receiving vitamin K and fresh frozen plasma, he was taken to the operating room for a temporary rigid maxillomandibular fixation. A 1:1 mixing study with normal plasma corrected the prothrombin time (decreasing from 40.7 to 14.7 seconds) and a factor VII assay revealed 5% of the normal factor VII level. The patient was diagnosed with congenital factor VII deficiency. Due to his coagulopathy and the extensive surgical correction needed, rFVIIa was administered and surgery was accomplished without hemorrhagic sequelae. Conclusion This case report and review describes a rare congenital disease, the history of rFVIIa use, and its mechanism. rFVIIA use in our patient provided a treatment option that allowed the necessary surgical correction, but further prospective studies on dose optimization would ensure adequate dosing with minimal risk of

  18. EDS V25 containment vessel explosive qualification test report.

    Energy Technology Data Exchange (ETDEWEB)

    Rudolphi, John Joseph

    2012-04-01

    The V25 containment vessel was procured by the Project Manager, Non-Stockpile Chemical Materiel (PMNSCM) as a replacement vessel for use on the P2 Explosive Destruction Systems. It is the first EDS vessel to be fabricated under Code Case 2564 of the ASME Boiler and Pressure Vessel Code, which provides rules for the design of impulsively loaded vessels. The explosive rating for the vessel based on the Code Case is nine (9) pounds TNT-equivalent for up to 637 detonations. This limit is an increase from the 4.8 pounds TNT-equivalency rating for previous vessels. This report describes the explosive qualification tests that were performed in the vessel as part of the process for qualifying the vessel for explosive use. The tests consisted of a 11.25 pound TNT equivalent bare charge detonation followed by a 9 pound TNT equivalent detonation.

  19. VII International Congress of Engineering Physics

    Science.gov (United States)

    2015-01-01

    In the frame of the fortieth anniversary celebration of the Universidad Autónoma Metropolitana and the Physics Engineering career, the Division of Basic Science and Engineering and its Departments organized the "VII International Congress of Physics Engineering". The Congress was held from 24 to 28 November 2014 in Mexico City, Mexico. This congress is the first of its type in Latin America, and because of its international character, it gathers experts on physics engineering from Mexico and all over the globe. Since 1999, this event has shown research, articles, projects, technological developments and vanguard scientists. These activities aim to spread, promote, and share the knowledge of Physics Engineering. The topics of the Congress were: • Renewable energies engineering • Materials technology • Nanotechnology • Medical physics • Educational physics engineering • Nuclear engineering • High precision instrumentation • Atmospheric physics • Optical engineering • Physics history • Acoustics This event integrates lectures on top trending topics with pre-congress workshops, which are given by recognized scientists with an outstanding academic record. The lectures and workshops allow the exchange of experiences, and create and strengthen research networks. The Congress also encourages professional mobility among all universities and research centres from all countries. CIIF2014 Organizing and Editorial Committee Dr. Ernesto Rodrigo Vázquez Cerón Universidad Autónoma Metropolitana - Azcapotzalco ervc@correo.azc.uam.mx Dr. Luis Enrique Noreña Franco Universidad Autónoma Metropolitana - Azcapotzalco lnf@correo.azc.uam.mx Dr. Alberto Rubio Ponce Universidad Autónoma Metropolitana - Azcapotzalco arp@correo.azc.uam.mx Dr. Óscar Olvera Neria Universidad Autónoma Metropolitana - Azcapotzalco oon@correo.azc.uam.mx Professor Jaime Granados Samaniego Universidad Autónoma Metropolitana - Azcapotzalco jgs@correo.azc.uam.mx Dr. Roberto Tito Hern

  20. Serendipitous Discovery of Factor VII Deficiency and the Ensuing Dilemma.

    Science.gov (United States)

    Umakanthan, Jayadev M; Dhakal, Prajwal; Gundabolu, Krishna; Koepsell, Scott A; Baljevic, Muhamed

    2018-03-01

    Congenital factor VII deficiency is a challenging disorder to manage, as it is associated with varied genotypes that do not clinically correlate with a bleeding phenotype. Individuals with severe factor VII deficiency (FVII: c 5%) may experience severe hemorrhages. In modern medicine, due to extensive routine pre-operative laboratory testing, clinically asymptomatic patients without any bleeding history might be incidentally discovered, raising clinical dilemmas. Careful consideration of bleeding versus thrombosis risk has to be made in such cases, especially in the elderly. Clinical history of no prior bleeding complications may be a reassuring factor. Minimal required replacement dosing of recombinant activated factor VII can be given peri-operatively in such situations, with close monitoring.

  1. Factor VII Deficiency: Clinical Phenotype, Genotype and Therapy.

    Science.gov (United States)

    Napolitano, Mariasanta; Siragusa, Sergio; Mariani, Guglielmo

    2017-03-28

    Factor VII deficiency is the most common among rare inherited autosomal recessive bleeding disorders, and is a chameleon disease due to the lack of a direct correlation between plasma levels of coagulation Factor VII and bleeding manifestations. Clinical phenotypes range from asymptomatic condition-even in homozygous subjects-to severe life-threatening bleedings (central nervous system, gastrointestinal bleeding). Prediction of bleeding risk is thus based on multiple parameters that challenge disease management. Spontaneous or surgical bleedings require accurate treatment schedules, and patients at high risk of severe hemorrhages may need prophylaxis from childhood onwards. The aim of the current review is to depict an updated summary of clinical phenotype, laboratory diagnosis, and treatment of inherited Factor VII deficiency.

  2. Factor VII deficiency: a single-center experience.

    Science.gov (United States)

    Salcioglu, Zafer; Akcay, Arzu; Sen, Hulya Sayilan; Aydogan, Gonul; Akici, Ferhan; Tugcu, Deniz; Ayaz, Nuray Aktay; Baslar, Zafer

    2012-11-01

    Congenital factor VII deficiency is the most common form of rare coagulation factor deficiencies. This article presents a retrospective evaluation of 73 factor VII deficiency cases that had been followed at our center. The study consisted of 48 males and 25 females (2 months-19 years). Thirty-one (42.5%) of them were asymptomatic. Out of symptomatic patients, 17 had severe clinical symptoms, whereas 8 presented with moderate and 17 with mild symptoms. The symptoms listed in order of frequency were as follows: epistaxis, petechia or ecchymose, easy bruising, and oral cavity bleeding. The genotype was determined in 8 patients. Recombinant activated factor VII (rFVIIa) was used to treat 49 bleeding episodes in 8 patients after 2002. In 2 patients with repeated central nervous system bleeding prophylaxis with rFVIIa was administered. No allergic and thrombotic events were observed during both treatment and prophylaxis courses. Antibody occurrence was not detected in the patients during treatment.

  3. Perturbation fields in W VII-AS and Helias configurations

    International Nuclear Information System (INIS)

    Harmeyer, E.; Kisslinger, J.; Montvai, A.; Rau, F.; Wobig, H.

    1988-01-01

    Effects of pertubed topologies of the W VII-AS vacuum fields on the configuration with rational and irrational rotational transform are illustrated. Even small perturbation fields are unacceptable at rational values of the rotational transform. For example at a rotational transform = 1/2 in W VII-AS, when exceeding an effective homogeneous Bx/B = 3 x 10 -4 , the size of the rotational transform = 1/2 = 5/10 islands is doubled. At irrational values a Bx/B = 1/2% shows tolerable effects, for both W VII-AS and HS4-12. At rational values of the rotational transform = 1 near the edge, Bx/B values = 1/4 to 1/8% show a rather large increase of the aspect ratio, so an edge value of rotational transform = 1 should be avoided

  4. ECRH experiments on the W VII-A stellarator

    International Nuclear Information System (INIS)

    Whilelm, R.; Erckmann, V.; Janzen, G.; Mueller, G.; Schueller, P. G.; Schwoerer, K.; Thumm, H.

    1985-01-01

    Plasma build-up and heating of a ''currentless'' plasma by means of ECR wave irradiation were studied at the Garching W VII-A stellarator. The experiments were performed at 28 GHz with approx. 200 kW RF power and a pulse duration 02 mode corresponding to a 50% O-mode and 50% X-mode mixture) was launched directly into the plasma from the low field side. In a second step the radiation was converted into the almost linearly polarized TE 11 mode and irradiated in O-mode orientation (E-tilde parallel to B-barsub(o), k-bar perpendicular to B-barsub(o)) into the torus, the nonabsorbed part of the RF power was reflected into the plasma in the X-mode by a focussing polarization twist reflector mounted to the inner torus wall. As a main result the heating efficiency has been slightly improved by the transition from ''simple'' to ''advanced'' wave launching (up to 50% instead of approx. 40%). The central electron temperatures were remarkably increased from approx. 700 eV to 1200 eV due to the well localized O-mode absorption of the TE 11 beam, however. The X-mode from the mirror on the other hand does not contribute to the total plasma energy as expected. This is explained by a local absorption of the arising Bernstein waves due to a macroscopically turbulent behaviour of the plasma in the outer regions. Possibly as a result of wave decay into lower hybrid waves pronounced ion tail heating was observed. For both kinds of wave irradiation toroidal plasma currents were generated. This seems to be caused by asimmetrically confined co- and counter-streaming fast electrons

  5. Metallurgy of steels for PWR pressure vessels

    International Nuclear Information System (INIS)

    Kepka, M.; Mocek, J.; Barackova, L.

    1980-01-01

    A survey and the chemical compositions are presented of reactor pressure vessel steels. The metallurgy is described of steel making for pressure vessels in Japan and the USSR. Both acidic and alkaline open-hearth steel is used for the manufacture of ingots. The leading world manufacturers of forging ingots for pressure vessels, however, exclusively use electric steel. Vacuum casting techniques are exclusively used. Experience is shown gained with the introduction of the manufacture of forging ingots for pressure vessels at SKODA, Plzen. The metallurgical procedure was tested utilizing alkaline open hearths, electric arc furnaces and facilities for vacuum casting of steel. Pure charge raw materials should be used for securing high steel purity. Prior to forging pressure vessel rings, not only should sufficiently big bottoms and heads be removed but also the ingot middle part should be scrapped showing higher contents of impurities and nonhomogeneous structure. (B.S.)

  6. Metallurgy of steels for PWR pressure vessels

    Energy Technology Data Exchange (ETDEWEB)

    Kepka, M; Mocek, J; Barackova, L [Skoda, Plzen (Czechoslovakia)

    1980-09-01

    A survey and the chemical compositions are presented of reactor pressure vessel steels. The metallurgy is described of steel making for pressure vessels in Japan and the USSR. Both acidic and alkaline open-hearth steel is used for the manufacture of ingots. The leading world manufacturers of forging ingots for pressure vessels, however, exclusively use electric steel. Vacuum casting techniques are exclusively used. Experience is shown gained with the introduction of the manufacture of forging ingots for pressure vessels at SKODA, Plzen. The metallurgical procedure was tested utilizing alkaline open hearths, electric arc furnaces and facilities for vacuum casting of steel. Pure charge raw materials should be used for securing high steel purity. Prior to forging pressure vessel rings, not only should sufficiently big bottoms and heads be removed but also the ingot middle part should be scrapped showing higher contents of impurities and nonhomogeneous structure.

  7. Plasmodium falciparum ookinete expression of plasmepsin VII and plasmepsin X.

    Science.gov (United States)

    Li, Fengwu; Bounkeua, Viengngeun; Pettersen, Kenneth; Vinetz, Joseph M

    2016-02-24

    Plasmodium invasion of the mosquito midgut is a population bottleneck in the parasite lifecycle. Interference with molecular mechanisms by which the ookinete invades the mosquito midgut is one potential approach to developing malaria transmission-blocking strategies. Plasmodium aspartic proteases are one such class of potential targets: plasmepsin IV (known to be present in the asexual stage food vacuole) was previously shown to be involved in Plasmodium gallinaceum infection of the mosquito midgut, and plasmepsins VII and plasmepsin X (not known to be present in the asexual stage food vacuole) are upregulated in Plasmodium falciparum mosquito stages. These (and other) parasite-derived enzymes that play essential roles during ookinete midgut invasion are prime candidates for transmission-blocking vaccines. Reverse transcriptase PCR (RT-PCR) was used to determine timing of P. falciparum plasmepsin VII (PfPM VII) and plasmepsin X (PfPM X) mRNA transcripts in parasite mosquito midgut stages. Protein expression was confirmed by western immunoblot and immunofluorescence assays (IFA) using anti-peptide monoclonal antibodies (mAbs) against immunogenic regions of PfPM VII and PfPM X. These antibodies were also used in standard membrane feeding assays (SMFA) to determine whether inhibition of these proteases would affect parasite transmission to mosquitoes. The Mann-Whitney U test was used to analyse mosquito transmission assay results. RT-PCR, western immunoblot and immunofluorescence assay confirmed expression of PfPM VII and PfPM X in mosquito stages. Whereas PfPM VII was expressed in zygotes and ookinetes, PfPM X was expressed in gametes, zygotes, and ookinetes. Antibodies against PfPM VII and PfPM X decreased P. falciparum invasion of the mosquito midgut when used at high concentrations, indicating that these proteases play a role in Plasmodium mosquito midgut invasion. Failure to generate genetic knockouts of these genes limited determination of the precise role of

  8. PERANCANGAN SISTEM INFORMASI DI PTAIS KOPERTAIS WILAYAH VII SUMATERA SELATAN

    Directory of Open Access Journals (Sweden)

    Fenny Purwani

    2015-12-01

    Full Text Available Relations and information technology today closely related. One technology that is widely used and very popular on the Internet is a website. The website is agood means to facilitate and share information as much to college. However, the college today togetthe informationisnot maximized. This study aimstobuildawebsite on Kopertais SUMBAGSEL region VII. This website was developed using Macromedia Dreamweaver CS3 software, PHP, and MySQL, and method development using RAD (Rapid Application Development, and the purpose of this website serves to facilitate the college to receiver elevant information about online Kopertais VII region and terupdates.

  9. Pressure vessel design manual

    CERN Document Server

    Moss, Dennis R

    2013-01-01

    Pressure vessels are closed containers designed to hold gases or liquids at a pressure substantially different from the ambient pressure. They have a variety of applications in industry, including in oil refineries, nuclear reactors, vehicle airbrake reservoirs, and more. The pressure differential with such vessels is dangerous, and due to the risk of accident and fatality around their use, the design, manufacture, operation and inspection of pressure vessels is regulated by engineering authorities and guided by legal codes and standards. Pressure Vessel Design Manual is a solutions-focused guide to the many problems and technical challenges involved in the design of pressure vessels to match stringent standards and codes. It brings together otherwise scattered information and explanations into one easy-to-use resource to minimize research and take readers from problem to solution in the most direct manner possible. * Covers almost all problems that a working pressure vessel designer can expect to face, with ...

  10. Recombinant factor VIIa treatment for asymptomatic factor VII deficient patients going through major surgery.

    Science.gov (United States)

    Livnat, Tami; Shenkman, Boris; Spectre, Galia; Tamarin, Ilia; Dardik, Rima; Israeli, Amnon; Rivkind, Avraham; Shabtai, Moshe; Marinowitz, Uri; Salomon, Ophira

    2012-07-01

    Factor VII deficiency is the most common among the rare autosomal recessive coagulation disorders worldwide. In factor VII deficient patients, the severity and clinical manifestations cannot be reliably determined by factor VII levels. Severe bleeding tends to occur in individuals with factor VII activity levels of 2% or less of normal. Patients with 2-10% factor VII vary between asymptomatic to severe life threatening haemorrhages behaviour. Recombinant factor VIIa (rFVIIa) is the most common replacement therapy for congenital factor VII deficiency. However, unlike haemophilia patients for whom treatment protocols are straight forward, in asymptomatic factor VII deficiency patients it is still debatable. In this study, we demonstrate that a single and very low dose of recombinant factor VIIa enabled asymptomatic patients with factor VII deficiency to go through major surgery safely. This suggestion was also supported by thrombin generation, as well as by thromboelastometry.

  11. Tumor Blood Vessel Dynamics

    Science.gov (United States)

    Munn, Lance

    2009-11-01

    ``Normalization'' of tumor blood vessels has shown promise to improve the efficacy of chemotherapeutics. In theory, anti-angiogenic drugs targeting endothelial VEGF signaling can improve vessel network structure and function, enhancing the transport of subsequent cytotoxic drugs to cancer cells. In practice, the effects are unpredictable, with varying levels of success. The predominant effects of anti-VEGF therapies are decreased vessel leakiness (hydraulic conductivity), decreased vessel diameters and pruning of the immature vessel network. It is thought that each of these can influence perfusion of the vessel network, inducing flow in regions that were previously sluggish or stagnant. Unfortunately, when anti-VEGF therapies affect vessel structure and function, the changes are dynamic and overlapping in time, and it has been difficult to identify a consistent and predictable normalization ``window'' during which perfusion and subsequent drug delivery is optimal. This is largely due to the non-linearity in the system, and the inability to distinguish the effects of decreased vessel leakiness from those due to network structural changes in clinical trials or animal studies. We have developed a mathematical model to calculate blood flow in complex tumor networks imaged by two-photon microscopy. The model incorporates the necessary and sufficient components for addressing the problem of normalization of tumor vasculature: i) lattice-Boltzmann calculations of the full flow field within the vasculature and within the tissue, ii) diffusion and convection of soluble species such as oxygen or drugs within vessels and the tissue domain, iii) distinct and spatially-resolved vessel hydraulic conductivities and permeabilities for each species, iv) erythrocyte particles advecting in the flow and delivering oxygen with real oxygen release kinetics, v) shear stress-mediated vascular remodeling. This model, guided by multi-parameter intravital imaging of tumor vessel structure

  12. The importance of residues 195-206 of human blood clotting factor VII in the interaction of factor VII with tissue factor

    International Nuclear Information System (INIS)

    Wildgoose, P.; Kisiel, W.; Kazim, A.L.

    1990-01-01

    Previous studies indicated that human and bovine factor VII exhibit 71% amino acid sequence identity. In the present study, competition binding experiments revealed that the interaction of human factor VII with cell-surface human tissue factor was not inhibited by 100-fold molar excess of bovine factor VII. This finding indicated that bovine and human factor VII are not structurally homologous in the region(s) where human factor VII interacts with human tissue factor. On this premise, the authors synthesized three peptides corresponding to regions of human factor VII that exhibited marked structural dissimilarity to bovine factor VII; these regions of dissimilarity included residues 195-206, 263-274, and 314-326. Peptide 195-206 inhibited the interaction of factor VII with cell-surface tissue factor and the activation of factor X by a complex of factor VIIa and tissue factor half-maximally at concentrations of 1-2 mM. A structurally rearranged form of peptide 195-206 containing an aspartimide residue inhibited these reactions half-maximally at concentrations of 250-300 μM. In contrast, neither peptide 263-274 nor peptide 314-326, at 2 mM concentration, significantly affected either factor VIIa interaction with tissue factor or factor VIIa-mediated activation of factor X. The data provide presumptive evidence that residues 195-206 of human factor VII are involved in the interaction of human factor VII with the extracellular domain of human tissue factor apoprotein

  13. Maury Journals - German Vessels

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — German vessels observations, after the 1853 Brussels Conference that set International Maritime Standards, modeled after Maury Marine Standard Observations.

  14. Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo

    DEFF Research Database (Denmark)

    Sidelmann, Johannes J; Skouby, Sven O; Kluft, Cornelis

    2011-01-01

    Oral contraceptive (OC) use influences the hemostatic system significantly and is a risk factor for development of cardiovascular disease. Factor VII-activating protease (FSAP) has potential effects on hemostasis. The 1601GA genotype of the 1601G/A polymorphism in the FSAP gene expresses a FSAP...... progestins. FSAP genotypes, FSAP and factor VII (FVII) plasma measures were assessed at baseline and after 6 cycles of OC. The 1601GA genotype was present in 49 (8.3%) of the women and was associated with significantly reduced levels of FSAP (P=0.001). OC use increased FSAP antigen by 25% and FSAP activity...

  15. 76 FR 31892 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Science.gov (United States)

    2011-06-02

    ... Requirements Under Title VII, the ADA, and GINA AGENCY: Equal Employment Opportunity Commission. ACTION: Notice... Civil Rights Act of 1964 (Title VII) and the Americans with Disabilities Act (ADA) to entities covered... the same record retention requirements under GINA that are imposed under Title VII and the ADA, i.e...

  16. 76 FR 79065 - Recordkeeping and Reporting Requirements Under Title VII, the ADA and GINA

    Science.gov (United States)

    2011-12-21

    ... Reporting Requirements Under Title VII, the ADA and GINA CFR Correction In Title 29 of the Code of Federal... title VII or section 107 of the ADA'' and add in their place the words ``section 709(c) of title VII, section 107 of the ADA, or section 207(a) of GINA'' wherever they appear in the following sections...

  17. In silico dissection of Type VII Secretion System components across ...

    Indian Academy of Sciences (India)

    2016-02-12

    Feb 12, 2016 ... Bio-Sciences R&D Division, TCS Innovation Labs, Tata Research Development & Design Centre, ... Type VII Secretion System (T7SS) is one of the factors involved in virulence of ... Such wide distribution of T7SS and.

  18. Prophylactic treatment of hereditary severe factor VII deficiency in pregnancy.

    Science.gov (United States)

    Pfrepper, Christian; Siegemund, Annelie; Hildebrandt, Sven; Kronberg, Juliane; Scholz, Ute; Niederwieser, Dietger

    2017-09-01

    : Severe hereditary factor VII deficiency is a rare bleeding disorder and may be associated with a severe bleeding phenotype. We describe a pregnancy in a 33-year-old woman with compound heterozygous factor VII deficiency and a history of severe menorrhagia and mucocutaneous bleedings. After discontinuation of contraceptives, menstruation was covered with recombinant activated factor VII (rFVIIa), and during pregnancy, rFVIIa had to be administered in first trimester in doses ranging from 15 to 90 μg/kg per day because of recurrent retroplacental hematomas and vaginal bleedings. Thrombin generation was measured in first trimester at different doses of rFVIIa and showed an increase in lag time when doses of less than 30 μg/kg/day were administered, whereas time to thrombin peak and peak thrombin were not influenced. A low-dose rFVIIa prophylactic treatment of 15 μg/kg every other day in the late second and in the third trimester was sufficient to allow a successful childbirth in this patient with severe factor VII deficiency.

  19. In silico dissection of Type VII Secretion System components across

    Indian Academy of Sciences (India)

    Type VII Secretion System (T7SS) is one of the factors involved in virulence of Mycobacteriun tuberculosis H37Rv. Numerous research efforts have been made in the last decade towards characterizing the components of this secretion system. An extensive genome-wide analysis through compilation of isolated information ...

  20. Statistics and Title VII Proof: Prima Facie Case and Rebuttal.

    Science.gov (United States)

    Whitten, David

    1978-01-01

    The method and means by which statistics can raise a prima facie case of Title VII violation are analyzed. A standard is identified that can be applied to determine whether a statistical disparity is sufficient to shift the burden to the employer to rebut a prima facie case of discrimination. (LBH)

  1. Extended analyses of Se VII and Se VIII

    International Nuclear Information System (INIS)

    Vankleef, Th.A.M.; Joshi, Y.N.

    1984-01-01

    Joshi et al. (1984) have conducted an analysis of the 3d8 4s-3d8 4p transitions in As VII. The present investigation is concerned with an analysis of similar transitions in Se VIII. The selenium spectrum was photographed in the 400-1200-A wavelength region on a variety of normal-incidence spectrographs. Attention is given to least-squares-fit (LSF) and Hartree-Fock (HF) parameter values for the 3d9 4d configuration of Se VII, LSF and HF parameter values for the 3d8 4s and 3d8 4p configurations of Se VIII, the energy and composition of the levels of the 3d9 4d configuration of Se VII, classified lines in Se VII, energy levels and composition of the 3d8 4s configuration and the revised and newly determined levels of the 3d8 4p configuration of Se VIII, and newly classified lines of Se VIII. 15 references

  2. Viis aastakümmet raamatukogunduse radadel / Anne Veinberg

    Index Scriptorium Estoniae

    Veinberg, Anne

    2008-01-01

    Arvustus: Kikas, Konrad. Verba volant, scripta manent : viis aastakümmet raamatukogunduse ja infoteaduse radadel = Verba volant, scripta manent : five decades on the field of librarianship and information science. - Tallinn : Tallinna Tehnikaülikooli Kirjastus, 2008. - 366 lk. : ill. portr. - (Tallinna Tehnikaülikooli Raamatukogu töid. A ; 5)

  3. Viis armastuslugu suurel ekraanil / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2008-01-01

    Viis näidet filmiajaloost, kus režissööri ja staari vahel on tunded : Roger Vadim ja Tema Naised, Werner Herzog ja Klaus Kinski, Federico Fellini ja Anita Ekberg, Quentin Tarantino ja Uma Thurman, Rainer Werner Fassbinder ja Mr/Mrs X

  4. Design concept for vessels and heat exchangers

    International Nuclear Information System (INIS)

    Elfmann, W.; Ferrari, L.D.B.

    1981-01-01

    A design concept for vessels and heat exchangers against internal and external loads resulting from normal operation and accident is shown. A definition and explanation of the operating conditions and stress levels are given. A description of the type of analysis (stress, fatigue, deformation, stability, earthquake and vibration) is presented in detail, also including technical guidelines which are used for the vessels and heat exchangers and their individual structure parts. (Author) [pt

  5. FAKTOR-FAKTOR YANG MEMENGARUHI PRODUKSI GULA PTPN VII (PERSERO

    Directory of Open Access Journals (Sweden)

    Rizky Savitri

    2014-09-01

    Full Text Available ABSTRACTThis study aimed to analyze the influence of the level of sugar cane yield, labor, production process period, and supporting materials on the production of PTPN VII (Persero PG. Cinta Manis, as well as analyzing the elasticity of production and business scale  of PTPN VII (Persero PG. Cinta Manis. The method used to analyze the data were quantitative analysis of Cobb Douglas production function with ordinary least square method to observe variable influences of PG. Cinta Manis sugar production. Cobb Douglas estimation results indicate that the level of sugar cane yield, labor, production process period, and supporting materials affect sugar production in PTPN VII (Persero PG. Cinta Manis. Production elasticity of each production factor shows that the use of production factors is not yet optimal, while the production scale of the company is Increasing Return to Scale (IRTS in which the proportion of additional input will produce output with the larger proportion. Accordingly, company should utilize the factors of production optimally, improve the quality of human resources with various activities to improve skills, increase the productivity of land by having land intensification, and optimize milling period by improving the quality of machine.Keywords: PG. Cinta Manis, increasing return to scale, Cobb Douglas function, PTPN VIIABSTRAKPenelitian ini bertujuan menganalisis pengaruh tingkat rendemen, tenaga kerja, bahan pembantu dan lama lama giling terhadap produksi gula PTPN VII (Persero PG. Cinta Manis, sekaligus menganalisis elastisitas produksi dan skala usaha PTPN VII (Persero PG. Cinta Manis. Metode analisis data yang digunakan adalah  analisis kuantitatif. Analisis kuantitatif pada penelitian ini menggunakan fungsi produksi cobb douglas dengan metode ordinary least square untuk melihat pengaruh variabel-variabel yang telah ditentukan terhadap produksi gula PG. Cinta Manis. Hasil estimasi cobb douglas menunjukkan  bahwa tingkat

  6. A thermal insulation system intended for a prestressed concrete vessel

    International Nuclear Information System (INIS)

    Aubert, Gilles; Petit, Guy.

    1975-01-01

    The description is given of a thermal insulation system withstanding the pressure of a vaporisable fluid for a prestressed concrete vessel, particularly the vessel of a boiling water nuclear reactor. The ring in the lower part of the vessel has, between the fluid inlet pipes and the bottom of the vessel, an annular opening of which the bottom edge is integral with an annular part rising inside the ring and parallel to it. This ring is hermetically connected to the bottom of the vessel and is coated with a metal lagging, at least facing the annular opening. This annular opening is made in the ring half-way up between the fluid inlet pipes and the bottom of the vessel. It is connected to the bottom of the vessel through the internal structure enveloping the reactor core [fr

  7. Reactor vessel sealing plug

    International Nuclear Information System (INIS)

    Dooley, R.A.

    1986-01-01

    This invention relates to an apparatus and method for sealing the cold leg nozzles of a nuclear reactor pressure vessel from a remote location during maintenance and inspection of associated steam generators and pumps while the pressure vessel and refueling canal are filled with water. The apparatus includes a sealing plug for mechanically sealing the cold leg nozzle from the inside of a reactor pressure vessel. The sealing plugs include a primary and a secondary O-ring. An installation tool is suspended within the reactor vessel and carries the sealing plug. The tool telescopes to insert the sealing plug within the cold leg nozzle, and to subsequently remove the plug. Hydraulic means are used to activate the sealing plug, and support means serve to suspend the installation tool within the reactor vessel during installation and removal of the sealing plug

  8. Containment vessel drain system

    Science.gov (United States)

    Harris, Scott G.

    2018-01-30

    A system for draining a containment vessel may include a drain inlet located in a lower portion of the containment vessel. The containment vessel may be at least partially filled with a liquid, and the drain inlet may be located below a surface of the liquid. The system may further comprise an inlet located in an upper portion of the containment vessel. The inlet may be configured to insert pressurized gas into the containment vessel to form a pressurized region above the surface of the liquid, and the pressurized region may operate to apply a surface pressure that forces the liquid into the drain inlet. Additionally, a fluid separation device may be operatively connected to the drain inlet. The fluid separation device may be configured to separate the liquid from the pressurized gas that enters the drain inlet after the surface of the liquid falls below the drain inlet.

  9. Preparation of factor VII concentrate using CNBr-activated Sepharose 4B immunoaffinity chromatography.

    Science.gov (United States)

    Mousavi Hosseini, Kamran; Nasiri, Saleh

    2015-01-01

    Factor VII concentrates are used in patients with congenital or acquired factor VII deficiency or treatment of hemophilia patients with inhibitors. In this research, immunoaffinity chromatography was used to purify factor VII from prothrombin complex (Prothrombin- Proconvertin-Stuart Factor-Antihemophilic Factor B or PPSB) which contains coagulation factors II, VII, IX and X. The aim of this study was to improve purity, safety and tolerability as a highly purified factor VII concentrate. PPSB was prepared using DEAE-Sephadex and was used as the starting material for purification of coagulation factor VII. Prothrombin complex was treated by solvent/detergent at 24°C for 6 h with constant stirring. The mixture of PPSB in the PBS buffer was filtered and then chromatographed using CNBr-activated Sepharose 4B coupled with specific antibody. Factors II, IX, VII, X and VIIa were assayed on the fractions. Fractions of 48-50 were pooled and lyophilized as a factor VII concentrate. Agarose gel electrophoresis was performed and Tween 80 was measured in the factor VII concentrate. Specific activity of factor VII concentrate increased from 0.16 to 55.6 with a purificationfold of 347.5 and the amount of activated factor VII (FVIIa) was found higher than PPSB (4.4-fold). RESULTS of electrophoresis on agarose gel indicated higher purity of Factor VII compared to PPSB; these finding revealed that factor VII migrated as alpha-2 proteins. In order to improve viral safety, solvent-detergent treatment was applied prior to further purification and nearly complete elimination of tween 80 (2 μg/ml). It was concluded that immuonoaffinity chromatography using CNBr-activated Sepharose 4B can be a suitable choice for large-scale production of factor VII concentrate with higher purity, safety and activated factor VII.

  10. Comprehending the structure of a vacuum vessel and in-vessel components of fusion machines. 1. Comprehending the vacuum vessel structure

    International Nuclear Information System (INIS)

    Onozuka, Masanori; Nakahira, Masataka

    2006-01-01

    The functions, conditions and structure of vacuum vessel using tokamak fusion machines are explained. The structural standard and code of vacuum vessel, process of vacuum vessel design, and design of ITER vacuum vessel are described. Production and maintenance of ultra high vacuum, confinement of radioactive materials, support of machines in vessel and electromagnetic force, radiation shield, plasma vertical stability, one-turn electric resistance, high temperature baking heat and remove of nuclear heat, reduce of troidal ripple, structural standard, features of safety of nuclear fusion machines, subjects of structural standard of fusion vacuum vessel, design flow of vacuum vessel, establishment of radial build, selections of materials, baking and cooling method, basic structure, structure of special parts, shield structure, and of support structure, and example of design of structure, ITER, are stated. (S.Y.)

  11. 76 FR 18132 - Interest on Untimely Paid Vessel Repair Duties

    Science.gov (United States)

    2011-04-01

    ... related to certain CBP revenue functions. List of Subjects 19 CFR Part 4 Administrative practice and... CFR Parts 4 and 24 [Docket No. USCBP-2008-0085] RIN 1515-AD74 Interest on Untimely Paid Vessel Repair... Federal Regulations (19 CFR) to provide that where an owner or master of a vessel documented under the...

  12. Dance Therapy: Focus on Dance VII.

    Science.gov (United States)

    Mason, Kathleen Criddle, Ed.

    This document is a collection of essays by various authors on the subject of dance therapy. Dance therapy, in the introduction of this document, is defined as a form of psychotherapy in which the therapist utilizes movement interaction as the primary means of accomplishing therapeutic goals. The document is divided into five parts: a)…

  13. 46 CFR 105.05-1 - Commercial fishing vessels dispensing petroleum products.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Commercial fishing vessels dispensing petroleum products... MISCELLANEOUS VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Application § 105.05-1 Commercial fishing vessels dispensing petroleum products. (a) The provisions of this part, with the exception of...

  14. NCSX Vacuum Vessel Fabrication

    International Nuclear Information System (INIS)

    Viola ME; Brown T; Heitzenroeder P; Malinowski F; Reiersen W; Sutton L; Goranson P; Nelson B; Cole M; Manuel M; McCorkle D.

    2005-01-01

    The National Compact Stellarator Experiment (NCSX) is being constructed at the Princeton Plasma Physics Laboratory (PPPL) in conjunction with the Oak Ridge National Laboratory (ORNL). The goal of this experiment is to develop a device which has the steady state properties of a traditional stellarator along with the high performance characteristics of a tokamak. A key element of this device is its highly shaped Inconel 625 vacuum vessel. This paper describes the manufacturing of the vessel. The vessel is being fabricated by Major Tool and Machine, Inc. (MTM) in three identical 120 o vessel segments, corresponding to the three NCSX field periods, in order to accommodate assembly of the device. The port extensions are welded on, leak checked, cut off within 1-inch of the vessel surface at MTM and then reattached at PPPL, to accommodate assembly of the close-fitting modular coils that surround the vessel. The 120 o vessel segments are formed by welding two 60 o segments together. Each 60 o segment is fabricated by welding ten press-formed panels together over a collapsible welding fixture which is needed to precisely position the panels. The vessel is joined at assembly by welding via custom machined 8-inch (20.3 cm) wide spacer ''spool pieces''. The vessel must have a total leak rate less than 5 X 10 -6 t-l/s, magnetic permeability less than 1.02(micro), and its contours must be within 0.188-inch (4.76 mm). It is scheduled for completion in January 2006

  15. Radioactive waste processing vessel

    International Nuclear Information System (INIS)

    Hayashi, Masaru; Suzuki, Osamu; Ishizaki, Kanjiro.

    1987-01-01

    Purpose: To obtain a vessel of a reduced weight and with no external leaching of radioactive materials. Constitution: The vessel main body is constituted, for example, with light weight concretes or foamed concretes, particularly, foamed concretes containing fine closed bubbles in the inside. Then, layers having dense texture made of synthetic resin such as polystylene, vinylchloride resin, etc. or metal plate such as stainless plate are integrally disposed to the inner surface of the vessel main body. The cover member also has the same structure. (Sekiya, K.)

  16. Tempest in a vessel

    International Nuclear Information System (INIS)

    Barre, Bertrand

    2015-01-01

    As the ASN made some statements about anomalies of carbon content in the EPR vessel bottom and top, the author recalls and comments some technical issues to better understand the information published on this topic. He notably addresses the role of the vessel, briefly indicates its operating conditions, shape and structure, and mechanical components for the top, its material and mechanical properties, and test samples used to assess mechanical properties. He also comments the phenomenon of radio-induced embrittlement, the vessel manufacturing process, and evokes the applicable regulations. He quotes and comments statements made by the ASN and Areva which evoke further assessments of the concerned components

  17. Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism: differences between older men and women

    NARCIS (Netherlands)

    Mennen, L. I.; de Maat, M. P.; Schouten, E. G.; Kluft, C.; de Jong, P. T.; Hofman, A.; Grobbee, D. E.

    1997-01-01

    Coagulation factor VII activity (FVII:C) is a risk indicator for cardiovascular disease. It is related to serum-triglycerides and the R/Q353 polymorphism (alleles R and Q) in the gene coding for factor VII is strongly associated with factor VII. The association of serum-triglycerides with factor VII

  18. Pressure vessel for a BWR type reactor

    International Nuclear Information System (INIS)

    Shimamoto, Yoshiharu.

    1980-01-01

    Purpose: To prevent the retention of low temperature water and also prevent the thermal fatigue of the pressure vessel by making large the curvature radius of a pressure vessel of a feed water sparger fitting portion and accelerating the mixing of low-temperature water at the feed water sparger base and in-pile hot water. Constitution: The curvature radius of the corner of the feed water sparger fitting portion in a pressure vessel is formed largely. In-pile circulating water infiltrates up to the base portion of the feed water sparger to carry outside low-temperature water at the base part, which is mixed with in-pile hot water. Accordingly, low temperature water does not stay at the base portion of the feed water sparger and generation of thermal fatigue in the pressure vessel can be prevented and the safety of the BWR type reactor can be improved. (Yoshino, Y.)

  19. Wine vessels (Vasa vinaria in roman law

    Directory of Open Access Journals (Sweden)

    Aličić Samir

    2017-01-01

    Full Text Available The notion of 'wine vessels' in Roman law comprises all the winecontaining recipients. There is no legal standardization of wine vessels by means of volume, and although the terms amphora, urna and culleus are used to designate both the vessels and the units of measure, these are two different meanings of the terms. In regard of the question, whether the vessels make appurtenance of the wine, jurisprudents of proculean school divided them in two categories. In the first category are those that follow legal status of wine, usually amphoras and other jars (cadi which are used for 'packaging', i. e. 'bottling' of the wine. The second category make mostly vats (cuppae and ceramic cisterns (dolia, which don't follow legal status of wine, making instead part of farming equipment of a landed property (instrumentum fundi and it's appurtenance. But, the roman jurists are not consistent regarding criteria for distinguishing these two categories.

  20. Manipulation of the membrane binding site of vitamin K-dependent proteins: Enhanced biological function of human factor VII

    OpenAIRE

    Shah, Amit M.; Kisiel, Walter; Foster, Donald C.; Nelsestuen, Gary L.

    1998-01-01

    Recent studies suggested that modification of the membrane contact site of vitamin K-dependent proteins may enhance the membrane affinity and function of members of this protein family. The properties of a factor VII mutant, factor VII-Q10E32, relative to wild-type factor VII (VII, containing P10K32), have been compared. Membrane affinity of VII-Q10E32 was about 20-fold higher than that of wild-type factor VII. The rate of autoactivation VII-Q10E32 with soluble tissue factor was 100-fold fast...

  1. Cheboygan Vessel Base

    Data.gov (United States)

    Federal Laboratory Consortium — Cheboygan Vessel Base (CVB), located in Cheboygan, Michigan, is a field station of the USGS Great Lakes Science Center (GLSC). CVB was established by congressional...

  2. High Performance Marine Vessels

    CERN Document Server

    Yun, Liang

    2012-01-01

    High Performance Marine Vessels (HPMVs) range from the Fast Ferries to the latest high speed Navy Craft, including competition power boats and hydroplanes, hydrofoils, hovercraft, catamarans and other multi-hull craft. High Performance Marine Vessels covers the main concepts of HPMVs and discusses historical background, design features, services that have been successful and not so successful, and some sample data of the range of HPMVs to date. Included is a comparison of all HPMVs craft and the differences between them and descriptions of performance (hydrodynamics and aerodynamics). Readers will find a comprehensive overview of the design, development and building of HPMVs. In summary, this book: Focuses on technology at the aero-marine interface Covers the full range of high performance marine vessel concepts Explains the historical development of various HPMVs Discusses ferries, racing and pleasure craft, as well as utility and military missions High Performance Marine Vessels is an ideal book for student...

  3. 2011 Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  4. 2011 Fishing Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  5. Pressurized Vessel Slurry Pumping

    International Nuclear Information System (INIS)

    Pound, C.R.

    2001-01-01

    This report summarizes testing of an alternate ''pressurized vessel slurry pumping'' apparatus. The principle is similar to rural domestic water systems and ''acid eggs'' used in chemical laboratories in that material is extruded by displacement with compressed air

  6. 2013 Tanker Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  7. Maury Journals - US Vessels

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — U.S. vessels observations, after the 1853 Brussels Conference that set International Maritime Standards, modeled after Maury Marine Standard Observations.

  8. Coastal Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels that have been issued a Federal permit for the Gulf of Mexico reef fish,...

  9. In-vessel tritium

    International Nuclear Information System (INIS)

    Ueda, Yoshio; Ohya, Kaoru; Ashikawa, Naoko; Ito, Atsushi M.; Kato, Daiji; Kawamura, Gakushi; Takayama, Arimichi; Tomita, Yukihiro; Nakamura, Hiroaki; Ono, Tadayoshi; Kawashima, Hisato; Shimizu, Katsuhiro; Takizuka, Tomonori; Nakano, Tomohide; Nakamura, Makoto; Hoshino, Kazuo; Kenmotsu, Takahiro; Wada, Motoi; Saito, Seiki; Takagi, Ikuji; Tanaka, Yasunori; Tanabe, Tetsuo; Yoshida, Masafumi; Toma, Mitsunori; Hatayama, Akiyoshi; Homma, Yuki; Tolstikhina, Inga Yu.

    2012-01-01

    The in-vessel tritium research is closely related to the plasma-materials interaction. It deals with the edge-plasma-wall interaction, the wall erosion, transport and re-deposition of neutral particles and the effect of neutral particles on the fuel recycling. Since the in-vessel tritium shows a complex nonlinear behavior, there remain many unsolved problems. So far, behaviors of in-vessel tritium have been investigated by two groups A01 and A02. The A01 group performed experiments on accumulation and recovery of tritium in thermonuclear fusion reactors and the A02 group studied theory and simulation on the in-vessel tritium behavior. In the present article, outcomes of the research are reviewed. (author)

  10. Reactor pressure vessel support

    International Nuclear Information System (INIS)

    Butti, J.P.

    1977-01-01

    A link and pin support system provides the primary vertical and lateral support for a nuclear reactor pressure vessel without restricting thermally induced radial and vertical expansion and contraction. (Auth.)

  11. 2013 Cargo Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  12. 2013 Fishing Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  13. 2013 Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  14. Ocean Station Vessel

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Ocean Station Vessels (OSV) or Weather Ships captured atmospheric conditions while being stationed continuously in a single location. While While most of the...

  15. Vessel Sewage Discharges

    Science.gov (United States)

    Vessel sewage discharges are regulated under Section 312 of the Clean Water Act, which is jointly implemented by the EPA and Coast Guard. This homepage links to information on marine sanitation devices and no discharge zones.

  16. Reactor pressure vessel design

    International Nuclear Information System (INIS)

    Foehl, J.

    1998-01-01

    As a result of the popularity of the Agencies report 'Neutron Irradiation Embrittlement of Reactor Pressure Vessel Steels' of 1975, it was decided that another report on this broad subject would be of use. In this report, background and contemporary views on specially identified areas of the subject are considered as self-contained chapters, written by experts. In chapter 2, the general principles of reactor pressure vessel design are elaborated. Crack and fracture initiation and propagation are treated in some detail

  17. Graywater Discharges from Vessels

    Science.gov (United States)

    2011-11-01

    metals (e.g., cadmium, chromium, lead, copper , zinc, silver, nickel, and mercury), solids, and nutrients (USEPA, 2008b; USEPA 2010). Wastewater from... flotation ), and disinfection (using ultraviolet light) as compared to traditional Type II MSDs that use either simple maceration and chlorination, or...Coliform Naval Vessels Oceanographic Vessels Small Cruise Ships 25a Vendor 2 Hamann AG Biological Treatment with Dissolved Air Flotation and

  18. Modifying EPA radiation risk models based on BEIR VII

    International Nuclear Information System (INIS)

    Pawel, D.; Puskin, J.

    2007-01-01

    This paper summarizes a 'draft White Paper' that provides details on proposed changes in EPA's methodology for estimating radiogenic cancer risks. Many of the changes are based on the contents of a recent National Academy of Sciences (NAS) report (BEIR VII), that addresses cancer and genetic risks from low doses of low-LET radiation. The draft White Paper was prepared for a meeting with the EPA's Science Advisory Board's Radiation Advisory Committee (RAC) in September for seeking advice on the application of BEIR VII and on issues relating to these modifications and expansions. After receiving the Advisory review, we plan to implement the changes by publishing the new methodology in an EPA report, which we expect to submit to the RAC for final review. The revised methodology could then be applied to update the cancer risk coefficients for over 800 radionuclides that are published in EPA's Federal Guidance Report 13. (author)

  19. LANL Robotic Vessel Scanning

    Energy Technology Data Exchange (ETDEWEB)

    Webber, Nels W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-11-25

    Los Alamos National Laboratory in J-1 DARHT Operations Group uses 6ft spherical vessels to contain hazardous materials produced in a hydrodynamic experiment. These contaminated vessels must be analyzed by means of a worker entering the vessel to locate, measure, and document every penetration mark on the vessel. If the worker can be replaced by a highly automated robotic system with a high precision scanner, it will eliminate the risks to the worker and provide management with an accurate 3D model of the vessel presenting the existing damage with the flexibility to manipulate the model for better and more in-depth assessment.The project was successful in meeting the primary goal of installing an automated system which scanned a 6ft vessel with an elapsed time of 45 minutes. This robotic system reduces the total time for the original scope of work by 75 minutes and results in excellent data accumulation and transmission to the 3D model imaging program.

  20. Vena porta thrombosis in patient with inherited factor VII deficiency

    DEFF Research Database (Denmark)

    Klovaite, Jolanta; Friis-Hansen, Lennart Jan; Larsen, Fin S

    2010-01-01

    Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman...... vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis....

  1. FFTF and CRBRP reactor vessels

    International Nuclear Information System (INIS)

    Morgan, R.E.

    1977-01-01

    The Fast Flux Test Facility (FFTF) reactor vessel and the Clinch River Breeder Reactor Plant (CRBRP) reactor vessel each serve to enclose a fast spectrum reactor core, contain the sodium coolant, and provide support and positioning for the closure head and internal structure. Each vessel is located in its reactor cavity and is protected by a guard vessel which would ensure continued decay heat removal capability should a major system leak develop. Although the two plants have significantly different thermal power ratings, 400 megawatts for FFTF and 975 megawatts for CRBRP, the two reactor vessels are comparable in size, the CRBRP vessel being approximately 28% longer than the FFTF vessel. The FFTF vessel diameter was controlled by the space required for the three individual In-Vessel Handling Machines and Instrument Trees. Utilization of the triple rotating plug scheme for CRBRP refueling enables packaging of the larger CRBRP core in a vessel the same diameter as the FFTF vessel

  2. Lack of bleeding in patients with severe factor VII deficiency.

    Science.gov (United States)

    Barnett, J Mark; Demel, Kurt C; Mega, Anthony E; Butera, James N; Sweeney, Joseph D

    2005-02-01

    Factor VII deficiency, although rare, is now recognized as the most common autosomal recessive inherited factor deficiency. It is usually considered to be associated with bleeding only in the severely affected subject and heterozygotes (>10%) are not considered at risk. The general recommendation for surgery is to achieve a FVII level in excess of 15% (0.15 1U/mL). We present three cases of severe factor VII deficiency, each of whom appeared hemostatically competent based on clinical history. Subject 1 is a 33 year-old African-American female with a baseline FVII of American female with a factor VII level of 9% who underwent an elective left total hip replacement without any factor replacement and had no excessive bleeding, but who sustained a pulmonary embolism postoperatively. Subject 3 is a 19-year-old African-American male with a baseline FVII of 1% with a history of active participation in football without noticeable injury and who underwent an emergent appendectomy without bleeding. These three cases represent individuals with the severe form of FVII deficiency who did not exhibit excessive bleeding when challenged with surgical procedures. The clinical history would appear the most valuable tool in predicting the likelihood of bleeding in these patients, and we suggest that the presumption that all patients with severe FVII deficiency should receive replacement therapy before surgical procedures may not be valid in all cases. Copyright 2005 Wiley-Liss, Inc.

  3. Integration of ITER in-vessel diagnostic components in the vacuum vessel

    International Nuclear Information System (INIS)

    Encheva, A.; Bertalot, L.; Macklin, B.; Vayakis, G.; Walker, C.

    2009-01-01

    The integration of ITER in-vessel diagnostic components is an important engineering activity. The positioning of the diagnostic components must correlate not only with their functional specifications but also with the design of the major parts of ITER torus, in particular the vacuum vessel, blanket modules, blanket manifolds, divertor, and port plugs, some of which are not yet finally designed. Moreover, the recently introduced Edge Localised Mode (ELM)/Vertical Stability (VS) coils mounted on the vacuum vessel inner wall call for not only more than a simple review of the engineering design settled down for several years now, but also for a change in the in-vessel distribution of the diagnostic components and their full impact has yet to be determined. Meanwhile, the procurement arrangement (a document defining roles and responsibilities of ITER Organization and Domestic Agency(s) (DAs) for each in-kind procurement including technical scope of work, quality assurance requirements, schedule, administrative matters) for the vacuum vessel must be finalized. These make the interface process even more challenging in terms of meeting the vacuum vessel (VV) procurement arrangement's deadline. The process of planning the installation of all the ITER diagnostics and integrating their installation into the ITER Integrated Project Schedule (IPS) is now underway. This paper covers the progress made recently on updating and issuing the interfaces of the in-vessel diagnostic components with the vacuum vessel, outlines the requirements for their attachment and summarises the installation sequence.

  4. First living-related liver transplant to cure factor VII deficiency.

    Science.gov (United States)

    Mohan, Neelam; Karkra, Sakshi; Jolly, Anu S; Vohra, Vijay; Mohanka, Ravi; Rastogi, Amit; Soin, A S

    2015-09-01

    Congenital factor VII deficiency is an autosomal recessive serious disorder of blood coagulation with wide genotypic and phenotypic variations. The clinical presentation can vary from asymptomatic patients to patients with major bleedings in severe deficiency (factor VII factor VII. Treatment modalities include FFP and repeated recombinant factor VII infusions. We hereby report the first successful LRLT for factor VII deficiency in an infant, the first-ever youngest baby reported worldwide. A six-month-old male child presented with easy bruisability, ecchymotic patches, hematuria, and convulsions. CT of the head showed subdural hemorrhage, which was treated conservatively. He had markedly increased PT (120 s) with normal platelets, and aPTT with factor VII level factor VII level was 57%. A factor VII infusion plan for pre-, intra- and postoperative periods was formulated and TEG followed. Postoperatively, his factor VII started increasing from third day and was 38% on 24th day with PT factor VII deficiency. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo

    DEFF Research Database (Denmark)

    Sidelmann, Johannes Jakobsen; Skouby, Sven O.; Kluft, Cornelis

    2011-01-01

    progestins. FSAP genotypes, FSAP and factor VII (FVII) plasma measures were assessed at baseline and after 6 cycles of OC. The 1601GA genotype was present in 49 (8.3%) of the women and was associated with significantly reduced levels of FSAP (P≤0.001). OC use increased FSAP antigen by 25% and FSAP activity......Oral contraceptive (OC) use influences the hemostatic system significantly and is a risk factor for development of cardiovascular disease. Factor VII-activating protease (FSAP) has potential effects on hemostasis. The 1601GA genotype of the 1601G/A polymorphism in the FSAP gene expresses a FSAP...... by 59% (P0.05). The relative increase in FSAP activity was significantly higher in women carrying the 1601GG genotype (63%) than in women carrying 1601GA genotype (50%) (P=0.01) and was associated with an increased activation of FVII. In conclusion: OC use increases the plasma measures of FSAP...

  6. Fast-neutron nuclear reactor vessel

    International Nuclear Information System (INIS)

    Presciuttini, L.

    1984-01-01

    The reactor vessel comprises a cylindrical shell, of which axis is vertical, coupled at its lower part with a dished bottom. The reactor core rests on a support plate bearing on the bottom of the vessel. The above dished bottom comprises a spherical sector having the same radius and the same axis as the cylindrical shell and joining the lower part of the shell, and a spherical head of which radius is a little more important than the spherical sector one. A cylindrical support for the reactor core is attached to the vessel at the joint between the two dished sections. The invention applies more particularly to integrated type reactors cooled by liquid sodium [fr

  7. Acrylic vessel cleaning tests

    International Nuclear Information System (INIS)

    Earle, D.; Hahn, R.L.; Boger, J.; Bonvin, E.

    1997-01-01

    The acrylic vessel as constructed is dirty. The dirt includes blue tape, Al tape, grease pencil, gemak, the glue or residue form these tapes, finger prints and dust of an unknown composition but probably mostly acrylic dust. This dirt has to be removed and once removed, the vessel has to be kept clean or at least to be easily cleanable at some future stage when access becomes much more difficult. The authors report on the results of a series of tests designed: (a) to prepare typical dirty samples of acrylic; (b) to remove dirt stuck to the acrylic surface; and (c) to measure the optical quality and Th concentration after cleaning. Specifications of the vessel call for very low levels of Th which could come from tape residues, the grease pencil, or other sources of dirt. This report does not address the concerns of how to keep the vessel clean after an initial cleaning and during the removal of the scaffolding. Alconox is recommended as the cleaner of choice. This acrylic vessel will be used in the Sudbury Neutrino Observatory

  8. First startup of the Siemens SL prototype magnets W VII in the IPP

    International Nuclear Information System (INIS)

    Amenda, W.; Kullmann, D.; Krueger, P.; Pillsticker, M.

    The first test results with a big superconductive prototype coil developed for the Garching Stellarator W VII are reported. Flux jumping at low currents did not start quenching. The critical current of the Nb-Ti coil reaches 91 percent of the short sample value. The stored energy at quenching is 1.83 MJ and the maximum value of the magnetic field in the winding region is 61.5 kG. The mechanical stresses did not damage the windings. Degradation was not observed. A training of the coil was not necessary. Altogether the test was successful, as important technical problems were satisfactorily solved. Only parts of cryogenic systems should be improved in order to reduce the helium losses. (U.S.)

  9. Radioactive liquid containing vessel

    International Nuclear Information System (INIS)

    Sakurada, Tetsuo; Kawamura, Hironobu.

    1993-01-01

    Cooling jackets are coiled around the outer circumference of a container vessel, and the outer circumference thereof is covered with a surrounding plate. A liquid of good conductivity (for example, water) is filled between the cooling jackets and the surrounding plate. A radioactive liquid is supplied to the container vessel passing through a supply pipe and discharged passing through a discharge pipe. Cooling water at high pressure is passed through the cooling water jackets in order to remove the heat generated from the radioactive liquid. Since cooling water at high pressure is thus passed through the coiled pipes, the wall thickness of the container vessel and the cooling water jackets can be reduced, thereby enabling to reduce the cost. Further, even if the radioactive liquid is leaked, there is no worry of contaminating cooling water, to prevent contamination. (I.N.)

  10. Tissue Factor–Factor VII Complex As a Key Regulator of Ovarian Cancer Phenotypes

    OpenAIRE

    Koizume, Shiro; Miyagi, Yohei

    2015-01-01

    Tissue factor (TF) is an integral membrane protein widely expressed in normal human cells. Blood coagulation factor VII (fVII) is a key enzyme in the extrinsic coagulation cascade that is predominantly secreted by hepatocytes and released into the bloodstream. The TF–fVII complex is aberrantly expressed on the surface of cancer cells, including ovarian cancer cells. This procoagulant complex can initiate intracellular signaling mechanisms, resulting in malignant phenotypes. Cancer tissues are...

  11. Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells

    OpenAIRE

    Yokota, N; Koizume, S; Miyagi, E; Hirahara, F; Nakamura, Y; Kikuchi, K; Ruf, W; Sakuma, Y; Tsuchiya, E; Miyagi, Y

    2009-01-01

    Background: Thromboembolic events are a major complication in ovarian cancer patients. Tissue factor (TF) is frequently overexpressed in ovarian cancer tissue and correlates with intravascular thrombosis. TF binds to coagulation factor VII (fVII), changing it to its active form, fVIIa. This leads to activation of the extrinsic coagulation cascade. fVII is produced by the liver and believed to be supplied from blood plasma at the site of coagulation. However, we recently showed that ovarian ca...

  12. 29 CFR 1604.8 - Relationship of title VII to the Equal Pay Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Relationship of title VII to the Equal Pay Act. 1604.8... GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.8 Relationship of title VII to the Equal Pay Act. (a) The... based on the Equal Pay Act may be raised in a proceeding under title VII. (c) Where such a defense is...

  13. In-service ultrasonic inspection of nuclear reactor pressure vessels

    International Nuclear Information System (INIS)

    Prepechal, J.; Sulc, J.

    1982-01-01

    Ultrasonic tests of pressure vessels for WWER 440 reactors, type 213 V, are carried out partly manually and partly by test equipment. The inner surface of the pressure vessel is tested using device REACTORTEST TRC which is fully mobile. The outer surface of the cylindrical parts and bottoms of the body is tested using handling equipment permanently in-built under the pressure vessel and dismountable testing heads. A set of these heads may be used for two reactor units. The testing equipment REACTORTEST TRC is equipped with a TRC 800 ultrasound device. The equipment for testing the outer surface of the vessel operates with the UDAR 16 ultrasound apparatus to which may be simultaneously connected 10 ultrasound probes and six probes for acoustic feedback. The whole system of ultrasonic tests makes possible a first-rate and reliable volume control of the whole pressure vessel and all points where cracks may originate and grow. (Z.M.)

  14. [Coagulation factor VII levels in uremic patients and theirs influence factors].

    Science.gov (United States)

    Fang, Jun; Xia, Ling-Hui; Wei, Wen-Ning; Song, Shan-Jun

    2004-12-01

    This study was aimed to investigate coagulation factor VII level in uremic patients with chronic renal failure and to explore theirs influence factors. The plasma levels of coagulation factor VII were detected in 30 uremic patients with chronic renal failure before and after hemodialysis for 1 month, the factor VII activity (FVII:C) was determined by one-stage coagulation method, while activated factor VII (FVIIa) was measured by one-stage coagulation method using recombinant soluble tissue factor, and factor VII antigen was detected by ELISA. The results showed that: (1) The FVIIa, FVII:C and FVIIAg levels in chronic uremic patients before hemodialysis were 4.00 +/- 0.86 microg/L, (148.5 +/- 40.4)% and (99.8 +/- 21.1)% respectively, which were significantly increased, as compared with healthy controls [2.77 +/- 1.02 microg/L, (113.1 +/- 33.0)% and (73.7 +/- 18.3)% respectively, P factor VII was positively correlated with levels of blood uria nitrogen and serum creatinine before hemodialysis but not after hemodialysis. It is concluded that the enhanced levels of coagulation factor VII in chronic uremic patients suggested abnormal activated state, herperactivity and elevated production of factor VII which correlated with renal functional injury. The abnormality of factor VII in uremia may be aggravated by hemodialysis. Coagulation factor (FVII) may be a risk factor for cardiovascular events in uremic patients who especially had been accepted long-term hemodialysis.

  15. Gene disruption reveals a dispensable role for plasmepsin VII in the Plasmodium berghei life cycle.

    Science.gov (United States)

    Mastan, Babu S; Kumari, Anchala; Gupta, Dinesh; Mishra, Satish; Kumar, Kota Arun

    2014-06-01

    Plasmepsins (PM), aspartic proteases of Plasmodium, comprises a family of ten proteins that perform critical functions in Plasmodium life cycle. Except VII and VIII, functions of the remaining plasmepsin members have been well characterized. Here, we have generated a mutant parasite lacking PM VII in Plasmodium berghei using reverse genetics approach. Systematic comparison of growth kinetics and infection in both mosquito and vertebrate host revealed that PM VII depleted mutants exhibited no defects in development and progressed normally throughout the parasite life cycle. These studies suggest a dispensable role for PM VII in Plasmodium berghei life cycle. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Uudised : Baltimaade suurim, XII "Jazzkaar". VII rahvusvaheline koorifestival. Leipzigis improviseeriti edukalt

    Index Scriptorium Estoniae

    2001-01-01

    23.-29. apr. toimuvast festivalist "Jazzkaar 2001". VII rahvusvahelisest koorifestivalist "Tallinn "2001". 6. ja 7. apr. Leipzigis toimunud V rahvusvahelisest improvisatsioonikonkursist, kus osalesid ka eesti interpreedid

  17. Extended analysis of six-times ionized barium (Ba VII)

    International Nuclear Information System (INIS)

    Sharma, M.K.; Tauheed, A.; Rahimullah, K.

    2013-01-01

    The seventh spectrum of barium (Ba VII) has been investigated using experimental recordings made on a 3-m normal incidence vacuum spectrograph in Canada in the wavelength region 300–2000 Å. The data below 350 Å was supplemented from the spectrograms recorded on a 10.7-m grazing incidence spectrograph of NIST laboratory USA. The sources used to excite the spectra in both the cases were triggered spark. Previously reported levels of 5s 2 5p 2 , 5s5p 3 , 5s 2 5p5d and 5s 2 5p6s in Ba VII have been confirmed except the 1 P 1 level of 5s 2 5p5d. The analysis has been extended considerably to include new configurations 5s 2 5p6d and 5s 2 5p7s in odd parity configuration and doubly excited configurations 5s 2 5p6p, 5s 2 5p4f, 5s 2 5p5f, 5p 4 , 5s5p 2 5d and 5s5p 2 6s in even parity configuration. The 3 F 4 level of 5s 2 5p5d configuration has now been established through the identification of transitions from 5s 2 5p6p. In all, one hundred twenty-two levels have been established in this spectrum out of which ninety-two are new. A configuration interaction Hartree–Fock calculation supports the analysis. -- Highlights: ► The spectrum of Ba was recorded on a 3-m spectrograph with triggered spark source. ► Atomic transitions for Ba VII were identified to established new energy levels. ► CI calculations with relativistic corrections were made for theoretical predictions. ► Weighted oscillator strength (gf) and transition probabilities (gA) were calculated

  18. Pressure vessel integrity 1991

    International Nuclear Information System (INIS)

    Bhandari, S.; Doney, R.O.; McDonald, M.S.; Jones, D.P.; Wilson, W.K.; Pennell, W.E.

    1991-01-01

    This volume contains papers relating to the structural integrity assessment of pressure vessels and piping, with special emphasis on nuclear industry applications. The papers were prepared for technical sessions developed under the sponsorship of the ASME Pressure Vessels and Piping Division Committees for Codes and Standards, Computer Technology, Design and Analysis, and Materials Fabrication. They were presented at the 1991 Pressure Vessels and Piping Division Conference in San Diego, California, June 23-27. The primary objective of the sponsoring organization is to provide a forum for the dissemination and discussion of information on development and application of technology for the structural integrity assessment of pressure vessels and piping. This publication includes contributions from authors from Australia, France, Japan, Sweden, Switzerland, the United Kingdom, and the United States. The papers here are organized in six sections, each with a particular emphasis as indicated in the following section titles: Fracture Technology Status and Application Experience; Crack Initiation, Propagation and Arrest; Ductile Tearing; Constraint, Stress State, and Local-Brittle-Zones Effects; Computational Techniques for Fracture and Corrosion Fatigue; and Codes and Standards for Fatigue, Fracture and Erosion/Corrosion

  19. The reactor vessel steels

    International Nuclear Information System (INIS)

    Bilous, W.; Hajewska, E.; Szteke, W.; Przyborska, M.; Wasiak, J.; Wieczorkowski, M.

    2005-01-01

    In the paper the fundamental steels using in the construction of pressure vessel water reactor are discussed. The properties of these steels as well as the influence of neutron irradiation on its degradation in the time of exploitation are also done. (authors)

  20. Vacuum distilling vessel

    Energy Technology Data Exchange (ETDEWEB)

    Reik, H

    1928-12-27

    Vacuum distilling vessel for mineral oil and the like, characterized by the ring-form or polyconal stiffeners arranged inside, suitably eccentric to the casing, being held at a distance from the casing by connecting members of such a height that in the resulting space if necessary can be arranged vapor-distributing pipes and a complete removal of the residue is possible.

  1. Visualization of vessel traffic

    NARCIS (Netherlands)

    Willems, C.M.E.

    2011-01-01

    Moving objects are captured in multivariate trajectories, often large data with multiple attributes. We focus on vessel traffic as a source of such data. Patterns appearing from visually analyzing attributes are used to explain why certain movements have occurred. In this research, we have developed

  2. GOLD PRESSURE VESSEL SEAL

    Science.gov (United States)

    Smith, A.E.

    1963-11-26

    An improved seal between the piston and die member of a piston-cylinder type pressure vessel is presented. A layer of gold, of sufficient thickness to provide an interference fit between the piston and die member, is plated on the contacting surface of at least one of the members. (AEC)

  3. Reactor vessel stud tensioner

    International Nuclear Information System (INIS)

    Malandra, L.J.; Beer, R.W.; Salton, R.B.; Spiegelman, S.R.; Cognevich, M.L.

    1982-01-01

    A quick-acting stud tensioner, for facilitating the loosening or tightening of a stud nut on a reactor vessel stud, has gripper jaws which when the tensioner is lowered into engagement with the upper end of the stud are moved inwards to grip the upper end and which when the tensioner is lifted move outward to release the upper end. (author)

  4. Neutron flux measurements at the Wendelstein VII-A stellarator

    International Nuclear Information System (INIS)

    Weller, A.; Maassberg, H.

    1985-10-01

    In addition to charge exchange analysis (CX) and charge exchange recombination spectroscopy (CXRS), the time evolution of the central ion temperature during neutral beam heated plasma discharges in the Wendelstein VII-A stellarator is derived from the neutron flux from thermal D-D reactions. In general, good quantitative agreement between the different methods is obtained. Neutron flux measurements also permit to investigate the slowing down of fast D + -ions from neutral beam injection (NBI). The results agree well with the predictions based on the assumption of a collisional slowing down mechanism. (orig.)

  5. Proceedings of the 2. Workshop on Wendelstein VII-X

    International Nuclear Information System (INIS)

    Rau, F.; Leotta, G.G.

    1988-01-01

    The specification and final concept of W VII-X were discussed. Plasma equilibrium; plasma stability; transport; bootstrap current; plasma parameter prediction methods; boundary regions; heating; the coil system; and mechanical engineering aspects were considered. A Helias configuration with five field periods (rather than the four previously suggested) is advocated. The major radius is increased to 6.5m to alleviate plasma-wall interaction effects due to the increased number of field periods. The magnetic field is reduced from 4 to 3T, to keep the amount of superconducting material needed for coils fixed

  6. Weighted oscillator strengths and lifetimes for the S VII spectrum

    International Nuclear Information System (INIS)

    Borges, F.O.; Cavalcanti, G.H.; Trigueiros, A.G.; Jupen, C.

    2004-01-01

    The weighted oscillator strengths (gf) and the lifetimes presented in this work were carried out in a multiconfiguration Hartree-Fock relativistic approach. In this calculation, the electrostatic parameters were optimized by a least-squares procedure, in order to improve the adjustment to experimental energy levels. This method produces gf-values that are in better agreement with intensity observations and lifetime values that are closer to the experimental ones. In this work, we presented all the experimentally known electric dipole S VII spectral lines

  7. Fuerzas Militares de Colombia Ejército Nacional VII División : el conflicto armado en las regiones

    OpenAIRE

    Sandoval M., Jairo Martin; Álvarez Bahena, Eyesid; Roldan Villa, Ana María; Consuegra, Claudia Patricia; Restrepo Marín, Janeth del Carmen; Gómez Yepes, William Arvey; Cardona Ángel, Yised; Zuluaga Parodi, David; Parada Contreras, Javier Antonio; López, Diana María; Blanco Mejia, Oscar; Flórez Giraldo, Lina Patricia; Martiínez Berdugo, Nathalia; Díaz Sáenz, María Juliana; Yunda Martínez, Alfonso

    2017-01-01

    El presente documento de investigación es resultado de un ejercicio de investigación de construcción de memoria histórica de la VII División del Ejército Nacional que hace parte de una serie nacional de diez tomos de contexto regional. Este ejercicio es desarrollado con el propósito de identificar y describir el desempeño que las unidades del Ejército Nacional tuvieron en el marco del desarrollo del conflicto armado en la región. El marco temporal e interpretativo que guió la construcción del...

  8. PDX vacuum vessel stress analysis

    International Nuclear Information System (INIS)

    Nikodem, Z.D.

    1975-01-01

    A stress analysis of PDX vacuum vessel is described and the summary of results is presented. The vacuum vessel is treated as a toroidal shell of revolution subjected to an internal vacuum. The critical buckling pressure is calculated. The effects of the geometrical discontinuity at the juncture of toroidal shell head and cylindrical outside wall, and the concavity of the cylindrical wall are examined. An effect of the poloidal field coil supports and the vessel outside supports on the stress distribution in the vacuum vessel is determined. A method evaluating the influence of circular ports in the vessel wall on the stress level in the vessel is outlined

  9. Equipment for decontamination of inner vessel surfaces featuring sound or ultrasound transducer on float inside liquid-filled vessel

    International Nuclear Information System (INIS)

    Bar, J.; Straka, M.

    1982-01-01

    The equipment for the decontamination of the inner surfaces of vessels consists of an immersion float which is provided with a screw, an electric motor, a rudder and at least one float chamber, and a remotely controlled valve. The float is provided with a power source, a high frequency a.c. current generator and a control panel outside the vessel. The float is connected to parts of the equipment outside the vessel by a multi-core cable. The immersion float may also be provided with a detector for measuring the quantity of ionizing radiation whose display is placed outside the vessel being decontaminated. (B.S.)

  10. Continuous infusion of recombinant activated factor VII for bleeding control after lobectomy in a patient with inherited factor VII deficiency.

    Science.gov (United States)

    Miyata, Naoko; Isaka, Mitsuhiro; Kojima, Hideaki; Maniwa, Tomohiro; Takahashi, Shoji; Takamiya, Osamu; Ohde, Yasuhisa

    2016-03-01

    Inherited factor VII (FVII) deficiency is a rare recessive inherited coagulation disorder with limited available information, especially in patients undergoing major thoracic surgery. In addition, an optimal management strategy for the disease has not been defined. We herein report a case involving a 61-year-old man with asymptomatic FVII deficiency who underwent a right middle and lower lobectomy to treat lung cancer. To the best of our knowledge, the present report is the first to describe the use of recombinant activated FVII continuous infusion for bleeding control after a major thoracic surgery in a patient with inherited FVII deficiency.

  11. Evaluated Nuclear Data Covariances: The Journey From ENDF/B-VII.0 to ENDF/B-VII.1

    International Nuclear Information System (INIS)

    Smith, Donald L.

    2011-01-01

    Recent interest from data users on applications that utilize the uncertainties of evaluated nuclear reaction data has stimulated the data evaluation community to focus on producing covariance data to a far greater extent than ever before. Although some uncertainty information has been available in the ENDF/B libraries since the 1970's, this content has been fairly limited in scope, the quality quite variable, and the use of covariance data confined to only a few application areas. Today, covariance data are more widely and extensively utilized than ever before in neutron dosimetry, in advanced fission reactor design studies, in nuclear criticality safety assessments, in national security applications, and even in certain fusion energy applications. The main problem that now faces the ENDF/B evaluator community is that of providing covariances that are adequate both in quantity and quality to meet the requirements of contemporary nuclear data users in a timely manner. In broad terms, the approach pursued during the past several years has been to purge any legacy covariance information contained in ENDF/B-VI.8 that was judged to be subpar, to include in ENDF/B-VII.0 (released in 2006) only those covariance data deemed then to be of reasonable quality for contemporary applications, and to subsequently devote as much effort as the available time and resources allowed to producing additional covariance data of suitable scope and quality for inclusion in ENDF/B-VII.1. Considerable attention has also been devoted during the five years since the release of ENDF/B-VII.0 to examining and improving the methods used to produce covariance data from thermal energies up to the highest energies addressed in the ENDF/B library, to processing these data in a robust fashion so that they can be utilized readily in contemporary nuclear applications, and to developing convenient covariance data visualization capabilities. Other papers included in this issue discuss in considerable

  12. IWR-solution for the ITER vacuum vessel assembly

    Energy Technology Data Exchange (ETDEWEB)

    Wu, H., E-mail: huapeng@lut.fi [Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland); Handroos, H. [Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland); Pela, P. [Tekes (Finland); Wang, Y. [Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland)

    2011-10-15

    The assembly of ITER vacuum vessel (VV) is still a very big challenge as the process can only be done from inside the VV. The welding of the VV assembly is carried out using the dedicated robotic systems. The main functions of the robots are: (i) measuring the actual space between every two sectors, (ii) positioning of the 150 kg splice plates between the sector shells, (iii) welding the splice plates to the sector shells, (iv) NDT of the welds, (v) repairing, including machining of the welds, (vi) He-leak tests of the welds, and (vii) the non-planned functions that may turn out. This paper presents a reasonable method to assemble the ITER VV. In this article, one parallel mobile robot, running on the track rail fixed on the wall inside the VV, is designed and tested. The assembling process, carried out by the mobile robot together with the welding robot, is presented.

  13. BEIR VII: What's old, What's new, and What challenges remain?

    International Nuclear Information System (INIS)

    Douple, E.; Jostes, R.

    2007-01-01

    The Biological Effects of Ionizing Radiation (BEIR VII) Committee reviewed evidence since the 1990 BEIR V report and developed BEIR VII risk estimates, including a linear, no-threshold dose-response relationship between exposure to ionizing radiation and the development of cancer in humans for exposures up to 0.1 Sv, quantifying the lifetime risks for both cancer mortality and incidence as a function of age at exposure and sex, primarily based on the Japanese atomic-bomb survivor data. If 100 people with an age distribution typical of the U.S. population receive an acute exposure of 0.1 Sv, one person would be expected to eventually develop cancer from this exposure, while 42 of the 100 people would be expected to develop cancer from other causes. The committee estimated the risk following radiation exposure for both incidence and mortality for 11 specific cancer sites. The total risk of heritable genetic diseases from parents exposed prior to conception was 3,000 to 4,700 cases per million progeny per Sv, 0.4-0.6% compared to an estimated baseline risk of 738,000 cases per million. Noncancer diseases such as cardiovascular disease can result from exposures to high doses of radiation, but the data available at this time are not sufficient to develop reliable estimates of risk for these noncancer outcomes at low doses of radiation. Twelve specific recommendations were presented as needs for future research. (author)

  14. Endf/B-VII.0 Based Library for Paragon - 313

    International Nuclear Information System (INIS)

    Huria, H.C.; Kucukboyaci, V.N.; Ouisloumen, M.

    2010-01-01

    A new 70-group library has been generated for the Westinghouse lattice physics code PARAGON using the ENDF/B-VII.0 nuclear data files. The new library retains the major features of the current library, including the number of energy groups and the reduction in the U-238 resonance integral. The upper bound for the up-scattering effects in the new library, however, has been moved to 4.0 eV from 2.1 eV for better MOX fuel predictions. The new library has been used to analyze standard benchmarks and also to compare the measured and predicted parameters for different types of Westinghouse and Combustion Engineering (CE) type operating reactor cores. Results indicate that the new library will not impact the reactivity, power distribution and the temperature coefficient predictions over a wide range of physics design parameters; however, will improve the MOX core predictions. In other words, the ENDF/B-VI.3 and ENDF/B-VII.0 produce similar results for reactor core calculations. (authors)

  15. Verification OFENDF/B-VII.0, ENDF/B-VII.1 and JENDL-4.0 nuclear data libraries for criticality calculations using NEA/NSC benchmarks

    International Nuclear Information System (INIS)

    Bouhaddane, A.; Farkas, G.; Hascik, J.; Slugen, V.

    2015-01-01

    The paper presents verification of selected nuclear data libraries with the aim to apply them to fast reactor calculations. More precise results were achieved for thermal neutrons calculations. This corresponds with the demand for more precise nuclear data for fast reactors. However, fast neutron calculations show some consistency, in particular between ENDF-B/VII.1 and JENDL-4.0 nuclear data libraries. The results support the idea to prefer using newer ENDF-B/VII.1 instead of the previous version ENDF-B/VII.0. Certainly, there are still some issues to be addressed and there is potential to gain more conclusive results. Although, application of ENDF-B/VII.1 and JENDL-4.0 is expected for further calculations. (authors)

  16. TMI-2 Vessel Investigation Project Metallurgical Program

    International Nuclear Information System (INIS)

    Diercks, D.R.; Neimark, L.A.

    1990-01-01

    The TMI-2 [Three Mile Island unit 2] Vessel Investigation Project Metallurgical Program at Argonne National Laboratory is a part of the international TMI-2 Vessel Investigation Project being conducted jointly by the U.S. Nuclear Regulatory Commission and the Organization for Economic Co-operation and Development (OECD). The overall project consists of three phases, namely (1) recovery of material samples from the lower head of the TMI-2 reactor, (2) examination and analysis of the lower head samples and the preparation and testing of archive material subjected to a similar thermal history, and (3) procurement, examination, and analysis of companion core material located adjacent to or near the lower head material. The specific objectives of the ANL Metallurgical Program, which accounts for a major portion of Phase 2, are to prepare metallographic and mechanical test specimen blanks from the TMI-2 lower head material, prepare similar test specimen blanks from suitable archive material subjected to the appropriate thermal processing, determine the mechanical properties of the lower vessel head and archive materials under the conditions of the core-melt accident, and assess the lower head integrity and margin-to-failure during the accident. The ANL work consists of three tasks: (1) archive materials program, (2) fabrication of metallurgical and mechanical test specimens from the TMI-2 pressure vessel samples, and (3) mechanical property characterization of TMI-2 lower pressure vessel head and archive material

  17. Vessels in Transit - Web Tool

    Data.gov (United States)

    Department of Transportation — A web tool that provides real-time information on vessels transiting the Saint Lawrence Seaway. Visitors may sort by order of turn, vessel name, or last location in...

  18. Evidence supporting the use of recombinant activated factor VII in congenital bleeding disorders

    DEFF Research Database (Denmark)

    Johansson, Pär I; Ostrowski, Sisse R

    2010-01-01

    Recombinant activated factor VII (rFVIIa, NovoSeven) was introduced in 1996 for the treatment of hemophilic patients with antibodies against coagulation factor VIII or IX.......Recombinant activated factor VII (rFVIIa, NovoSeven) was introduced in 1996 for the treatment of hemophilic patients with antibodies against coagulation factor VIII or IX....

  19. Recombinant activated factor VII in cardiac surgery: single-center experience.

    Science.gov (United States)

    Singh, Sarvesh Pal; Chauhan, Sandeep; Choudhury, Minati; Malik, Vishwas; Choudhary, Shiv Kumar

    2014-02-01

    The widespread off-label use of recombinant activated factor VII for the control of refractory postoperative hemorrhage continues despite a warning from the Food and Drug Administration. Although effective in reducing the need for transfusion of blood and blood products, safety concerns still prevail. To compare the dosing and efficacy of recombinant activated factor VII between pediatric and adult patients, and in the operating room and intensive care unit. The records of 69 patients (33 children and 36 adults) who underwent cardiovascular surgery and received recombinant activated factor VII were reviewed retrospectively. The dose of recombinant activated factor VII, mediastinal drainage, use of blood and blood products, incidence of thrombosis, and 28-day mortality were studied. the efficacy of recombinant activated factor VII was comparable in adults and children, despite the lower dose in adults. Prophylactic use of recombinant activated factor VII decreased the incidence of mediastinal exploration and the duration of intensive care unit stay. A 4.3% incidence of thrombotic complications was observed in this study. The efficacious dose of recombinant activated factor VII is much less in adults compared to children. Prophylactic use of recombinant activated factor VII decreases the dose required, the incidence of mediastinal exploration, and intensive care unit stay, with no survival benefit.

  20. Life-threatening bleeding in a case of autoantibody-induced factor VII deficiency.

    Science.gov (United States)

    Okajima, K; Ishii, M

    1999-02-01

    A male patient presented with life-threatening bleeding induced by autoantibody-induced factor VII (F.VII) deficiency. This patient had macroscopic hematuria, skin ecchymosis, gastrointestinal bleeding, and a neck hematoma that was causing disturbed respiration. He developed acute renal failure and acute hepatic failure, probably due to obstruction of the ureters and the biliary tract, respectively. Although activated partial thromboplastin time was normal, prothrombin time (PT) was remarkably prolonged at 71.8 seconds compared to 14.0 seconds in a normal control. Both the immunoreactive level of F.VII antigen and the F.VII activity of the patient's plasma samples were VII activity. These findings suggested the presence of a plasma inhibitor for F.VII. After administration of large doses of methylprednisolone, PT was gradually shortened and plasma levels of F.VII increased over time. Bleeding, acute renal failure, and acute hepatic failure improved markedly following the steroid treatment. These observations suggest that life-threatening bleeding can be induced by autoantibody-induced F.VII deficiency and that immunosuppressive therapy using large doses of steroid can be successful in inhibiting the production of the autoantibody.

  1. Mobile nuclear reactor containment vessel

    International Nuclear Information System (INIS)

    Thompson, R.E.; Spurrier, F.R.; Jones, A.R.

    1978-01-01

    A containment vessel for use in mobile nuclear reactor installations is described. The containment vessel completely surrounds the entire primary system, and is located as close to the reactor primary system components as is possible in order to minimize weight. In addition to being designed to withstand a specified internal pressure, the containment vessel is also designed to maintain integrity as a containment vessel in case of a possible collision accident

  2. Nuclear reactor vessel inspection apparatus

    International Nuclear Information System (INIS)

    Blackstone, E.G.; Lofy, R.A.; Williams, L.P.

    1979-01-01

    Apparatus for the in situ inspection of a nuclear reactor vessel to detect the location and character of flaws in the walls of the vessel, in the welds joining the various sections of the vessel, in the welds joining attachments such as nozzles, elbows and the like to the reactor vessel and in such attachments wherein an inspection head carrying one or more ultrasonic transducers follows predetermined paths in scanning the various reactor sections, welds and attachments

  3. Reactor vessel stud closure system

    International Nuclear Information System (INIS)

    Spiegelman, S.R.; Salton, R.B.; Beer, R.W.; Malandra, L.J.; Cognevich, M.L.

    1982-01-01

    A quick-acting stud tensioner apparatus for enabling the loosening or tightening of a stud nut on a reactor vessel stud. The apparatus is adapted to engage the vessel stud by closing a gripper around an upper end of the vessel stud when the apparatus is seated on the stud. Upon lifting the apparatus, the gripper releases the vessel stud so that the apparatus can be removed

  4. Reactor pressure vessel steels

    International Nuclear Information System (INIS)

    Van De Velde, J.; Fabry, A.; Van Walle, E.; Chaouuadi, R.

    1998-01-01

    Research and development activities related to reactor pressure vessel steels during 1997 are reported. The objectives of activities of the Belgian Nuclear Research Centre SCK/CEN in this domain are: (1) to develop enhanced surveillance concepts by applying micromechanics and fracture-toughness tests to small specimens, and by performing damage modelling and microstructure characterization; (2) to demonstrate a methodology on a broad database; (3) to achieve regulatory acceptance and industrial use

  5. Reactor Pressure Vessel Steels

    Energy Technology Data Exchange (ETDEWEB)

    Van de Velde, J.; Fabry, A.; Van Walle, E.; Chaoudi, R

    1998-07-01

    SCK-CEN's R and D programme on Reactor Pressure Vessel (RPV) Steels in performed in support of the RVP integrity assessment. Its main objectives are: (1) to develop enhanced surveillance concepts by applying micromechanics and fracture-toughness tests to small specimens, and by performing damage modelling and microstructure characterization; (2) to demonstrate the applied methodology on a broad database; (3) to achieve regulatory acceptance and industrial use. Progress and achievements in 1999 are reported.

  6. Modelling of the dynamics of the vessel and circuits of recirculation of a BWR type nucleo electric as part of the SUN-RAH university simulator; Modelado de la dinamica de la vasija y circuitos de recirculacion de una nucleoelectrica tipo BWR como parte del simulador universitario SUN-RAH

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez S, R A [DEPFI, Campus Morelos, en IMTA, Jiutepec, Morelos (Mexico)

    2003-07-01

    In the present project, the development of a model for the dynamics of the process of energy transport generated in the nuclear fuel until the main steam lines of a nucleo electric central with BWR type nuclear reactor, using mathematical models of reduced order is presented. These models present the main characteristics of the reactor vessel and of the recirculation system, defined by the main phenomena that intervene in those physical processes. Likewise, the objective of the general project of the one University student nucleo electric simulator with Boiling Water Reactor (SUN-RAH) for later on to establish the modeling equations for each part of the nuclear reactor as well as of the load pursuit system. Also, its were described the graphic interfaces implemented in an three layers architecture in which the different measuring variables are presented in the monitor. It fits signalize that the advantage presented by the University student nucleo electric simulator is the possibility to carry out changes in the magnitudes of those different variables that intervene in the physical processes made in the one reactor and in the recirculation system in execution time of the same one. Of same way, the creation of a graphic intuitive interface, friendly, and designed with the same technology with the one that the video games are programmed in the present time. Besides all the above mentioned, the pending goals inside of the project are exposed, as well as the developments in construction process or conceptualized to be included in future versions of the simulator. Finally its are thinking about possible scenarios of applications of SUN-RAH, as well as their reaches. (Author)

  7. Phenomenological vessel burst investigations

    International Nuclear Information System (INIS)

    Hippelein, K.W.; Julisch, P.; Muz, J.; Schiedermaier, J.

    1985-07-01

    Fourteen burst experiments have been carried out using vessels with circumferential and longitudinal flaws, for investigation of the fracture behaviour, i.e. the time-related fracture opening. The vessels had dimensions (outer diameter x wall thickness = 800 x 47 mm) which correspond to the dimensions of the main coolant piping of a 1300 MW e PWR. The test specimens had been made of the base-safe material 20 MnMoNi 55 and of a special, 22 NiMoCr 37 base alloy. The experimental conditions with regard to pressure and temperature have been chosen so as to correspond to normal operating conditions of a PWR (p∝17.5 MPa, T∝300 0 C), i.e. the flaws have been so dimensioned that failure was to be expected at a pressure of p∝17.5 MPa. As a rule, water has been used as the pressure medium, or in some cases air, in order to influence the time-dependent pressure decrease. Fluid and structural dynamics calculations have also been made. In order to determine the impact of a fast propagating crack on the leak-to-fracture curve, which normally is defined by quasistationary experiments, suitable tests have been made with large-volume, cylindrical vessels (outer diameter x wall thickness x length = 3000 x 21 x 14000 mm) made of the material WSt E 43. The leak-before-fracture criterion has been confirmed. (orig./HP) [de

  8. Blood Vessels in Allotransplantation.

    Science.gov (United States)

    Abrahimi, P; Liu, R; Pober, J S

    2015-07-01

    Human vascularized allografts are perfused through blood vessels composed of cells (endothelium, pericytes, and smooth muscle cells) that remain largely of graft origin and are thus subject to host alloimmune responses. Graft vessels must be healthy to maintain homeostatic functions including control of perfusion, maintenance of permselectivity, prevention of thrombosis, and participation in immune surveillance. Vascular cell injury can cause dysfunction that interferes with these processes. Graft vascular cells can be activated by mediators of innate and adaptive immunity to participate in graft inflammation contributing to both ischemia/reperfusion injury and allograft rejection. Different forms of rejection may affect graft vessels in different ways, ranging from thrombosis and neutrophilic inflammation in hyperacute rejection, to endothelialitis/intimal arteritis and fibrinoid necrosis in acute cell-mediated or antibody-mediated rejection, respectively, and to diffuse luminal stenosis in chronic rejection. While some current therapies targeting the host immune system do affect graft vascular cells, direct targeting of the graft vasculature may create new opportunities for preventing allograft injury and loss. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.

  9. Ionizing radiations and blood vessels

    International Nuclear Information System (INIS)

    Vorob'ev, E.I.; Stepanov, R.P.

    1985-01-01

    Data on phenomenology of radiation-induced changes in blood vessels are systematized and authors' experience is generalized. Modern concepts about processes leading to vessel structure injury after irradiation is critically analyzed. Special attention is paid to reparation and compensation of X-ray vessel injury, consideration of which is not yet sufficiently elucidated in literature

  10. Ionizing radiations and blood vessels

    International Nuclear Information System (INIS)

    Vorob'ev, E.I.; Stepanov, R.P.

    1985-01-01

    Data on phenomeology of radiation changes of blood vessels are systemized and the authors' experience is generalyzed. A critical analysis of modern conceptions on processes resulting in vessel structure damage after irradiation, is given. Special attention is paid to reparation and compensation of radiation injury of vessels

  11. The effects of three factor VII polymorphisms on factor VII coagulant levels in healthy Singaporean Chinese, Malay and Indian newborns.

    Science.gov (United States)

    Quek, S C; Low, P S; Saha, N; Heng, C K

    2006-11-01

    Factor VII (FVII) is an independent risk factor for coronary artery disease. Three polymorphisms of the factor VII gene (F7) were studied in a group of healthy newborns comprising 561 Chinese, 398 Malays and 226 Asian Indians from Singapore. The allele frequencies of 3 polymorphisms (R353Q, Promoter 0/10bp Del/Ins and Intron 7) in the FVII gene were ascertained through genotyping by polymerase chain reaction and restriction digestion of amplified fragments. In Chinese the minor allele frequencies are Q: 0.04, Ins: 0.03, R7: 0.44; Malays, Q: 0.06, Ins: 0.10, R7: 0.41; and Indians, Q: 0.25, Ins: 0.23, R7: 0.43. Strong linkage disequilibrium (Delta > 0.7) is observed between the 0/10 bp and the R353Q sites in all ethnic groups. We conclude that: (i) the prevalence of the minor Q and Ins alleles of the R353Q and 0/10 bp polymorphisms are significantly higher in the Indian newborns than the Chinese and Malays; (ii) the Q allele is significantly associated (p = 0.01) with a lower plasma FVII coagulant level in the Indian and Malay neonates; and this polymorphism explains up to 3.8% of the variance in FVII coagulant levels; (iii) there is no significant difference in allele frequencies of the three polymorphisms between neonates with and without family histories of CAD.

  12. Processing and analysis techniques involving in-vessel material generation

    Science.gov (United States)

    Schabron, John F [Laramie, WY; Rovani, Jr., Joseph F.

    2012-09-25

    In at least one embodiment, the inventive technology relates to in-vessel generation of a material from a solution of interest as part of a processing and/or analysis operation. Preferred embodiments of the in-vessel material generation (e.g., in-vessel solid material generation) include precipitation; in certain embodiments, analysis and/or processing of the solution of interest may include dissolution of the material, perhaps as part of a successive dissolution protocol using solvents of increasing ability to dissolve. Applications include, but are by no means limited to estimation of a coking onset and solution (e.g., oil) fractionating.

  13. Stress criteria for nuclear vessel concrete

    International Nuclear Information System (INIS)

    Costes, D.

    1975-01-01

    Concrete nuclear vessels are submitted to prestressing forces which limit tensile stresses in concrete when the vessel is under pressure with thermal gradients. Hence, the most severe conditions for concrete appear when the vessel is prestressed and not submitted to internal pressure. The triaxial states of stress in the concrete may be computed postulating elastic or other behavior and compared with safe limits obtained from rupture tests and fatigue tests. The first part of the paper, recalls experimental rupture results and the acceptability procedures currently used. Criteria founded on the lemniscoid surfaces are proposed, parameters for which are obtained by various tests and safety considerations. In the second part, rupture tests are reported on small, thick, cylindrical vessels submitted to external hydraulic pressure simulating prestressing forces. Materials used are plain concrete, microconcrete, marble and graphite. The strengths obtained are much higher than those which could be elastically computed, triaxial rupture states being provided by previous experiments. Such results may be due to a plastic stress redistribution before fracture and to stabilizing effects of stress gradients around the more stressed areas. Fatigue tests by external hydraulic loading are reported [fr

  14. Is prophylaxis required for delivery in women with factor VII deficiency?

    Science.gov (United States)

    Baumann Kreuziger, L M; Morton, Colleen T; Reding, Mark T

    2013-11-01

    Factor VII (fVII) deficiency is a rare congenital bleeding disorder in which fVII activity level and bleeding tendency do not completely correlate. Pregnancy and delivery present a significant haemostatic challenge to women with fVII deficiency. Treatment with recombinant factor VIIa (rfVIIa) carries a thrombotic risk and the literature is not clear whether prophylaxis is necessary prior to delivery. The aim of this study was to define management, haemorrhagic and thrombotic complications of pregnant women with fVII deficiency through a systematic review. Medical databases (PubMed, MEDLINE, CINAHL, Academic Search Premier, Cochrane Library, Web of Science and Scopus) were searched using "factor VII deficiency" and "pregnancy" or "surgery." Overall 34 articles, four abstracts, and three institutional cases were reviewed. Literature from 1953 to 2011 reported 94 live births from 62 women with fVII deficiency. The median fVII activity was 5.5%. Haemostatic prophylaxis was used in 32% of deliveries. Without prophylaxis, 40 vaginal deliveries and 16 caesarean sections were completed. The odds of receiving prophylaxis were 2.9 times higher in women undergoing caesarean section compared to vaginal delivery. Post-partum haemorrhage occurred in 10% of deliveries with prophylaxis and 13% of deliveries without prophylaxis. The fVII level did not significantly differ between women who did and did not receive prophylaxis. We present the only systematic review of the management of pregnancy in fVII deficient women. No difference in post-partum haemorrhage was seen in deliveries with and without prophylaxis. Therefore, we recommend that rfVIIa be available in the case of haemorrhage or surgical intervention, but not as mandatory prophylaxis. © 2013 John Wiley & Sons Ltd.

  15. Production and properties of monoclonal antibodies to human blood coagulation factor VII and factor VIIa

    International Nuclear Information System (INIS)

    Mann, P.; Nesbitt, J.A.; Ge, M.; Kisiel, W.

    1986-01-01

    Human factor VII is a trace vitamin K-dependent protein that circulates in blood as a single-chain precursor to a serine protease. Upon activation, two-chain factor VIIa activates factor x in the presence of tissue factor and calcium. Purified preparations of single-chain (SC) human factor VII and two-chain (TC) factor VIIa were utilized to immunize Balb/c mice. Spleen cells from these immunized mice were fused to a non-secreting NS-1 derivative of X63-Ag8 myeloma cells and grown in selective medium. Analysis of culture supernatants by EIA revealed several hybridomas that were secreting IgG specific for Sc-factor VII and TC-factor VIIa. In addition, several hybridomas secreted IgG that reacted equally well with factor VII and factor VIIa. One of the latter McAb (A-29) reacted with the heavy chain of factor VIIa and the intact factor VII molecule equally as judged by Western blotting. A-29 was produced in ascites fluid, purified and coupled to activated CH-Sepharose. Application of one liter of normal human plasma to 10 ml of this immunoadsorbent column, elution of factor VII and subsequent Western blot using 125 I-rabbit anti-human factor VII indicated a single species of factor VII(M/sub r/ = 50 KDa) in normal plasma. These specific factor VII/VIIa McAbs may prove useful in the analysis of these factors, and in the separation of SC-factor VII from TC-factor VIIa

  16. Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism: Differences between older men and women

    NARCIS (Netherlands)

    Mennen, L.I.; Maat, M.P.M. de; Schouten, E.G.; Kluft, C.; Jong, P.T.V.M. de; Hofman, A.; Grobbee, D.E.

    1997-01-01

    Coagulation factor VII activity (FVII:C) is a risk indicator for cardiovascular disease. It is related to serum-triglycerides and the R/Q353 polymorphism (alleles R and Q) in the gene coding for factor VII is strongly associated with factor VU[. The association of serum-triglycerides with factor VII

  17. 46 CFR 154.650 - Cargo tank and process pressure vessel welding.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo tank and process pressure vessel welding. 154.650... Equipment Construction § 154.650 Cargo tank and process pressure vessel welding. (a) Cargo tank and process pressure vessel welding must meet Subpart 54.05 and Part 57 of this chapter. (b) Welding consumables used...

  18. 75 FR 29569 - Certificate of Alternative Compliance for the Offshore Supply Vessel JANSON R. GRAHAM

    Science.gov (United States)

    2010-05-26

    ... Compliance for the Offshore Supply Vessel JANSON R. GRAHAM AGENCY: Coast Guard, DHS. ACTION: Notice. SUMMARY... supply vessel JANSON R. GRAHAM as required by 33 U.S.C. 1605(c) and 33 CFR 81.18. DATES: The Certificate..., Parts 81 and 89, has been issued for the offshore supply vessel JANSON R. GRAHAM, O.N. 1222117. Full...

  19. 75 FR 39955 - Certificate of Alternative Compliance for the Offshore Supply Vessel MONICA W CALLAIS

    Science.gov (United States)

    2010-07-13

    ... Compliance for the Offshore Supply Vessel MONICA W CALLAIS AGENCY: Coast Guard, DHS. ACTION: Notice. SUMMARY... supply vessel MONICA W CALLAIS as required by 33 U.S.C. 1605(c) and 33 CFR 81.18. DATES: The Certificate..., Parts 81 and 89, has been issued for the offshore supply vessel MONICA W CALLAIS, O.N. 1226851. The...

  20. 77 FR 17331 - Interest on Untimely Paid Vessel Repair Duties

    Science.gov (United States)

    2012-03-26

    ... interest as part of its inherent revenue collection functions in situations where an owner or master of a... delegate) to approve regulations related to certain CBP revenue functions. List of Subjects 19 CFR Part 4... CFR PARTS 4 and 24 [CBP Dec. 12-04; USCBP-2008-0085] RIN 1515-AD74 Interest on Untimely Paid Vessel...

  1. Effect of N-acetylcysteine on the accuracy of the prothrombin time assay of plasma coagulation factor II plus VII plus X activity in subjects infused with the drug. Influence of time and temperature

    DEFF Research Database (Denmark)

    Thorsen, S.; Teisner, A.; Jensen, S.A.

    2009-01-01

    Objectives: The prothrombin time (PT) assay of factor II+VII+X activity is an important predictor of liver damage in paracetamol poisoned patients. It complicates interpretation of results that the antidote, acetylcysteine (NAC) depresses this activity. The aim was to investigate if NAC influences...... added to plasma in vitro decreased factor II+VII+X activity at 37 degrees C in a time-dependent manner. This effect was quenched at temperatures 24 degrees C. Activity lost at 37 degrees C could partly be recovered by subsequent incubation at 5 or 20 degrees C. Incubation at 37 degrees C prior to assay...... led to a significant additional depression of factor II+VII+X activity in plasma from subjects infused with NAC during the first 3h of infusion indicating that it contained reactive NAC. The risk that this NAC interfered with the accuracy of the PT assay was considered minimal with samples stored...

  2. Isolated acquired factor VII deficiency: review of the literature.

    Science.gov (United States)

    Mulliez, Sylvie M N; Devreese, Katrien M J

    2016-04-01

    Isolated acquired factor VII (FVII) deficiency is a rare haemorrhagic disorder. We report what is currently known about the pathogenesis, clinical features, diagnosis, treatment and prognosis of acquired FVII deficiency. We performed a literature search and included all articles published between 1980 and August 2015. Acquired FVII deficiency has been reported in 42 patients. There are well-established clinical diseases associated with acquired FVII deficiency, most notably infections, malignancy and haematological stem cell transplantation. The exact pathogenesis of the diseases is still unknown, but different pathophysiological hypotheses have been suggested. The clinical manifestation of acquired FVII deficiency varies greatly in severity; asymptomatic course as well as severe life-threatening bleeding diathesis and fatal bleedings have been described.

  3. Purification and Autoactivation Method for Recombinant Coagulation Factor VII.

    Science.gov (United States)

    Granovski, Vladimir; Freitas, Marcela C C; Abreu-Neto, Mario Soares; Covas, Dimas T

    2018-01-01

    Recombinant coagulation factor VII is a very important and complex protein employed for treatment of hemophiliac patients (hemophilia A/B) who develop inhibitors antibodies to conventional treatments (FVIII and FIX). The rFVII is a glycosylated molecule and circulates in plasma as zymogen of 50 kDa. When activated the molecule is cleaved to 20-30 kDa and has a half-life of about 3 h, needing to be processed fast and efficiently until freeze-drying. Here, we describe a very simple and fast purification sequence for rFVII using affinity FVII Select resin and a dialysis system that can be easily scaled up.

  4. Inhibitor development after liver transplantation in congenital factor VII deficiency.

    Science.gov (United States)

    See, W-S Q; Chang, K-O; Cheuk, D K-L; Leung, Y-Y R; Chan, G C-F; Chan, S-C; Ha, S-Y

    2016-09-01

    Congenital factor VII (FVII) deficiency is the commonest type of the rare bleeding disorders. Very few cases of congenital FVII deficiency developed inhibitor and liver transplant is considered as definitive treatment. In the literature, twelve patients with congenital FVII deficiency developed inhibitors. Two had spontaneous resolution of inhibitors and one did not respond to high dose recombinant factor VIIa (rFVIIa) and died. Regarding liver transplant in congenital FVII patients, seven patients underwent liver transplant with good prognosis. We report a 5-year-old girl with confirmed severe congenital FVII deficiency since neonatal period. She suffered from recurrent intracranial bleeding despite rFVIIa replacement. After auxiliary liver transplant at the age of 4, she continued to show persistent deranged clotting profile and was found to have inhibitor towards FVII. Interestingly, she was still responsive to rFVIIa replacement. © 2016 John Wiley & Sons Ltd.

  5. Convenient synthesis of bis(alkoxy)rhenium(VII) complexes

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Z.; Al-Ajlouni, A.M.; Espenson, J.H. [Iowa State Univ., Ames, IA (United States)

    1996-02-28

    The study of high-oxidation-state organorhenium compounds has been a field of continuing activity, thanks to the success of methylrhenium trioxide (CH{sub 3}ReO{sub 3} or MTO) in catalytic processes. This catalyst is effective in oxidations, olefin metathesis, the olefination of aldehydes, and the preparation of other compounds with three-membered rings. The syntheses of some rhenium compounds derived form MTO have been reported. Epoxide formation is a key reaction, and it bears directly on these findings reported here. Re(VII) complexes containing a chelated bis(diolate) ligand can be synthesized by refluxing MTO with 2,3-dimethyl-2,3-diol. Here, the authors report a more convenient method for this preparation. A different series of related compounds consists of chelated bis(diolates) of the Cp*Re-oxo series, Cp*ReO-(diolate).

  6. Magnetic anomaly patterns over crustal blocks of the King Edward VII Peninsula, Marie Byrd Land, West Antarctica

    Directory of Open Access Journals (Sweden)

    M. Spano

    2000-06-01

    Full Text Available Within the framework of the GITARA II project an aeromagnetic survey was performed during the GANOVEXVII expedition (1992/1993 over the King Edward VII Peninsula in northwestern Marie Byrd Land (West Antarctica. This region which may represent the eastern flank of the Ross Sea rift system had previously been explored only at reconnaissance level. New total field and upward continued (10 km magnetic anomaly maps are produced and interpreted here to map and discuss the crustal structure of the Edward VII Peninsula. Tworound-shaped, high-amplitude magnetic anomalies are recognised over the Alexandra Mountains block. The anomalies are difficult to interpret since susceptibility data indicate the prevalence of non-magnetic rocks at the surface. A possible interpretation is that the anomalies are due to Cretaceous mafic intrusives distinct from weakly magnetic Byrd Coast Granite of the adjacent Rockefeller Mountains block. Alternatively the anomalies could be related to buried pluton-sized Devonian Ford Granodiorite intruded by dikes. If Cretaceous in age, the former intrusives revealed from the magnetics could also be responsible for contact metamorphism of the adjacent Alexandra Mountains migmatites. Lower amplitude circular anomalies over the Central Plateau and Prestrud Inlet are likely to be caused by unexposed Devonian Ford Granodiorite which crops out in the Ford Ranges. Elongated high-frequency anomalies of the Sulzberger Bay are similar to those recognised over seismically constrained Cenozoic rift-related volcanics of the Ross Sea. A broad magnetic low over the Sulzberger Ice Shelf may be indicative of a fault bounded graben-like basin with sedimentary infill. Overall recognition of magnetic anomaly patterns and trends reveals segmentation of the Edward VII Peninsula and of the adjacent marine areas in distinct crustal blocks. Faults may separate these blocks and they are interpreted to reflect multiple Cretaceous and maybe Cenozoic crustal

  7. Coagulation factor VII variants resistant to inhibitory antibodies.

    Science.gov (United States)

    Branchini, Alessio; Baroni, Marcello; Pfeiffer, Caroline; Batorova, Angelika; Giansily-Blaizot, Muriel; Schved, Jean F; Mariani, Guglielmo; Bernardi, Francesco; Pinotti, Mirko

    2014-11-01

    Replacement therapy is currently used to prevent and treat bleeding episodes in coagulation factor deficiencies. However, structural differences between the endogenous and therapeutic proteins might increase the risk for immune complications. This study was aimed at identifying factor (F)VII variants resistant to inhibitory antibodies developed after treatment with recombinant activated factor VII (rFVIIa) in a FVII-deficient patient homozygous for the p.A354V-p.P464Hfs mutation, which predicts trace levels of an elongated FVII variant in plasma. We performed fluorescent bead-based binding, ELISA-based competition as well as fluorogenic functional (activated FX and thrombin generation) assays in plasma and with recombinant proteins. We found that antibodies displayed higher affinity for the active than for the zymogen FVII (half-maximal binding at 0.54 ± 0.04 and 0.78 ± 0.07 BU/ml, respectively), and inhibited the coagulation initiation phase with a second-order kinetics. Isotypic analysis showed a polyclonal response with a large predominance of IgG1. We hypothesised that structural differences in the carboxyl-terminus between the inherited FVII and the therapeutic molecules contributed to the immune response. Intriguingly, a naturally-occurring, poorly secreted and 5-residue truncated FVII (FVII-462X) escaped inhibition. Among a series of truncated rFVII molecules, we identified a well-secreted and catalytically competent variant (rFVII-464X) with reduced binding to antibodies (half-maximal binding at 0.198 ± 0.003 BU/ml) as compared to the rFVII-wt (0.032 ± 0.002 BU/ml), which led to a 40-time reduced inhibition in activated FX generation assays. Taken together our results provide a paradigmatic example of mutation-related inhibitory antibodies, strongly support the FVII carboxyl-terminus as their main target and identify inhibitor-resistant FVII variants.

  8. Discovery of the type VII ESX-1 secretion needle?

    Science.gov (United States)

    Ates, Louis S; Brosch, Roland

    2017-01-01

    Mycobacterium tuberculosis, the etiological agent of human tuberculosis, harbours five ESAT-6/type VII secretion (ESX/T7S) systems. The first esx gene clusters were identified during the genome-sequencing project of M. tuberculosis H37Rv. Follow-up studies revealed additional genes playing important roles in ESX/T7S systems. Among the latter genes, one can find those that encode Pro-Glu (PE) and Pro-Pro-Glu (PPE) proteins as well as a gene cluster that is encoded >260 kb upstream of the esx-1 locus and encodes ESX-1 secretion-associated proteins EspA (Rv3616c), EspC (Rv3615c) and EspD (Rv3614c). The espACD cluster has been suggested to have an important function in ESX-1 secretion since EspA-EspC and EsxA-EsxB are mutually co-dependent on each other for secretion. However, the molecular mechanism of this co-dependence and interaction between the substrates remained unknown. In this issue of Molecular Microbiology, Lou and colleagues show that EspC forms high-molecular weight polymerization complexes that resemble selected components of type II, III and/or IV secretion systems of Gram-negative bacteria. Indeed, EspC-multimeric complexes form filamentous structures that could well represent a secretion needle of ESX-1 type VII secretion systems. This exciting observation opens new avenues for research to discover and characterize ESX/T7S components and elucidates the co-dependence of EsxA/B secretion with EspA/C. © 2016 John Wiley & Sons Ltd.

  9. Pressure vessel lid

    International Nuclear Information System (INIS)

    Schoening, J.; Elter, C.; Becker, G.; Pertiller, S.

    1986-01-01

    The invention concerns a lid for closing openings in reactor pressure vessels containing helium, which is made as a circular casting with hollow spaces and a flat floor and is set on the opening and kept down. It consists of helium-tight metal cast material with sufficient temperature resistance. There are at least two concentric heat resistant seals let into the bottom of the lid. The bottom is in immediate contact with the container atmosphere and has hollow spaces in its inside in the area opposite to the opening. (orig./HP) [de

  10. [Small vessel cerebrovascular disease].

    Science.gov (United States)

    Cardona Portela, P; Escrig Avellaneda, A

    2018-05-09

    Small vessel vascular disease is a spectrum of different conditions that includes lacunar infarction, alteration of deep white matter, or microbleeds. Hypertension is the main risk factor, although the atherothrombotic lesion may be present, particularly in large-sized lacunar infarctions along with other vascular risk factors. MRI findings are characteristic and the lesions authentic biomarkers that allow differentiating the value of risk factors and defining their prognostic value. Copyright © 2018 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Age-dependent regulation of ERF-VII transcription factor activity in Arabidopsis thaliana.

    Science.gov (United States)

    Giuntoli, Beatrice; Shukla, Vinay; Maggiorelli, Federica; Giorgi, Federico M; Lombardi, Lara; Perata, Pierdomenico; Licausi, Francesco

    2017-10-01

    The Group VII Ethylene Responsive Factors (ERFs-VII) RAP2.2 and RAP2.12 have been mainly characterized with regard to their contribution as activators of fermentation in plants. However, transcriptional changes measured in conditions that stabilize these transcription factors exceed the mere activation of this biochemical pathway, implying additional roles performed by the ERF-VIIs in other processes. We evaluated gene expression in transgenic Arabidopsis lines expressing a stabilized form of RAP2.12, or hampered in ERF-VII activity, and identified genes affected by this transcriptional regulator and its homologs, including some involved in oxidative stress response, which are not universally induced under anaerobic conditions. The contribution of the ERF-VIIs in regulating this set of genes in response to chemically induced or submergence-stimulated mitochondria malfunctioning was found to depend on the plant developmental stage. A similar age-dependent mechanism also restrained ERF-VII activity upon the core-hypoxic genes, independently of the N-end rule pathway, which is accounted for the control of the anaerobic response. To conclude, this study shed new light on a dual role of ERF-VII proteins under submergence: as positive regulators of the hypoxic response and as repressors of oxidative-stress related genes, depending on the developmental stage at which plants are challenged by stress conditions. © 2017 John Wiley & Sons Ltd.

  12. Tissue Factor–Factor VII Complex as a Key Regulator of Ovarian Cancer Phenotypes

    Directory of Open Access Journals (Sweden)

    Shiro Koizume

    2015-01-01

    Full Text Available Tissue factor (TF is an integral membrane protein widely expressed in normal human cells. Blood coagulation factor VII (fVII is a key enzyme in the extrinsic coagulation cascade that is predominantly secreted by hepatocytes and released into the bloodstream. The TF–fVII complex is aberrantly expressed on the surface of cancer cells, including ovarian cancer cells. This procoagulant complex can initiate intracellular signaling mechanisms, resulting in malignant phenotypes. Cancer tissues are chronically exposed to hypoxia. TF and fVII can be induced in response to hypoxia in ovarian cancer cells at the gene expression level, leading to the autonomous production of the TF–fVII complex. Here, we discuss the roles of the TF–fVII complex in the induction of malignant phenotypes in ovarian cancer cells. The hypoxic nature of ovarian cancer tissues and the roles of TF expression in endometriosis are discussed. Arguments will be extended to potential strategies to treat ovarian cancers based on our current knowledge of TF–fVII function.

  13. Tissue Factor-Factor VII Complex As a Key Regulator of Ovarian Cancer Phenotypes.

    Science.gov (United States)

    Koizume, Shiro; Miyagi, Yohei

    2015-01-01

    Tissue factor (TF) is an integral membrane protein widely expressed in normal human cells. Blood coagulation factor VII (fVII) is a key enzyme in the extrinsic coagulation cascade that is predominantly secreted by hepatocytes and released into the bloodstream. The TF-fVII complex is aberrantly expressed on the surface of cancer cells, including ovarian cancer cells. This procoagulant complex can initiate intracellular signaling mechanisms, resulting in malignant phenotypes. Cancer tissues are chronically exposed to hypoxia. TF and fVII can be induced in response to hypoxia in ovarian cancer cells at the gene expression level, leading to the autonomous production of the TF-fVII complex. Here, we discuss the roles of the TF-fVII complex in the induction of malignant phenotypes in ovarian cancer cells. The hypoxic nature of ovarian cancer tissues and the roles of TF expression in endometriosis are discussed. Arguments will be extended to potential strategies to treat ovarian cancers based on our current knowledge of TF-fVII function.

  14. (99)Tc(VII) Retardation, Reduction, and Redox Rate Scaling in Naturally Reduced Sediments.

    Science.gov (United States)

    Liu, Yuanyuan; Liu, Chongxuan; Kukkadapu, Ravi K; McKinley, James P; Zachara, John; Plymale, Andrew E; Miller, Micah D; Varga, Tamas; Resch, Charles T

    2015-11-17

    An experimental and modeling study was conducted to investigate pertechnetate (Tc(VII)O4(-)) retardation, reduction, and rate scaling in three sediments from Ringold formation at U.S. Department of Energy's Hanford site, where (99)Tc is a major contaminant in groundwater. Tc(VII) was reduced in all the sediments in both batch reactors and diffusion columns, with a faster rate in a sediment containing a higher concentration of HCl-extractable Fe(II). Tc(VII) migration in the diffusion columns was reductively retarded with retardation degrees correlated with Tc(VII) reduction rates. The reduction rates were faster in the diffusion columns than those in the batch reactors, apparently influenced by the spatial distribution of redox-reactive minerals along transport paths that supplied Tc(VII). X-ray computed tomography and autoradiography were performed to identify the spatial locations of Tc(VII) reduction and transport paths in the sediments, and results generally confirmed the newly found behavior of reaction rate changes from batch to column. The results from this study implied that Tc(VII) migration can be reductively retarded at Hanford site with a retardation degree dependent on reactive Fe(II) content and its distribution in sediments. This study also demonstrated that an effective reaction rate may be faster in transport systems than that in well-mixed reactors.

  15. An automated vessel segmentation of retinal images using multiscale vesselness

    International Nuclear Information System (INIS)

    Ben Abdallah, M.; Malek, J.; Tourki, R.; Krissian, K.

    2011-01-01

    The ocular fundus image can provide information on pathological changes caused by local ocular diseases and early signs of certain systemic diseases, such as diabetes and hypertension. Automated analysis and interpretation of fundus images has become a necessary and important diagnostic procedure in ophthalmology. The extraction of blood vessels from retinal images is an important and challenging task in medical analysis and diagnosis. In this paper, we introduce an implementation of the anisotropic diffusion which allows reducing the noise and better preserving small structures like vessels in 2D images. A vessel detection filter, based on a multi-scale vesselness function, is then applied to enhance vascular structures.

  16. The need to pressure test prestressed concrete reactor vessels

    International Nuclear Information System (INIS)

    Forgie, J.H.; Holland, J.A.

    1983-01-01

    In the period when PCRV were relatively unproven, proof pressure testing provided a useful demonstration of vessel integritiy and a confirmation of model testing and of analysis. No failures have occurred during concrete vessel tests in the UK or in the subsequent operational life of the vessels and much has been learned of their behaviour in service. The paper examines the advantages and disadvantages of proof testing PCRV in the light of the above increased knowledge of vessel performance. The paper draws attention to certain hypothetical loading cases that could be more onerous than the proof test and suggests that pressure testing could itself cause unnecessarily high loading to parts of the vessel. Always recognising the safety considerations and demonstrations of such are of prime importance, the authors suggest that a lower pressure level could be adopted without loss of original intent. In addition some ground rules are suggested as to cases where proof testing could be omitted. (orig./HP)

  17. 76 FR 20550 - Control of Emissions From New and In-Use Marine Compression-Ignition Engines and Vessels

    Science.gov (United States)

    2011-04-13

    ... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 1042 Control of Emissions From New and In-Use Marine Compression- Ignition Engines and Vessels CFR Correction In Title 40 of the Code of Federal Regulations, Part... service, whichever comes first. (2) For vessels with no Category 3 engines, a vessel that has been...

  18. Dismantling id the reactor pressure vessel insulation and dissecting of the MZFR reactor pressure vessel

    International Nuclear Information System (INIS)

    Loeb, Andreas; Stanke, Dieter; Thoma, Markus; Eisenmann, Beata; Prechtl, Erwin; Dehnke, Burckhard

    2008-01-01

    The MZFR reactor was decommissioned in 1984. The authors describe the dismantling of the reactor pressure vessel insulation that consists of asbestos containing mineral fiber wool. The appropriate remote handling and cutting tools had to be adapted with respect to the restrained space in the containment. The dismantling of the reactor pressure vessel has been completed, the dissected parts have been packaged into 200 containers for the final repository Konrad. During the total project time no reportable events and no damage to persons occurred.

  19. Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients.

    Science.gov (United States)

    van Geffen, Mark; Mathijssen, Natascha C J; Holme, Pål A; Laros-van Gorkom, Britta A P; van Kraaij, Marian G J; Masereeuw, Roselinde; Peyvandi, Flora; van Heerde, Waander L

    2013-07-01

    Recombinant activated factor VII (rFVIIa) and plasma-derived factor VII (pdFVII) are used to prevent bleedings in severe FVII deficient patients, despite their short half-lifes. It is suggested that FVII levels of 15-20 IU/dL are sufficient to maintain hemostasis. We analyzed the pharmacodynamic effects of FVII substitution therapy in the Nijmegen Hemostasis Assay (NHA) that simultaneously measures thrombin and plasmin generation. Ten severe FVII deficient patients were treated with 20 μg/kg rFVIIa or 25 IU/kg pdFVII in a cross-over design. Thrombin generation lag-time (TG-LT) was identified as an effect-response parameter. Pharmacodynamic analysis using a maximum effect model showed 50% reduction of the TG-LT effect at ~2 IU/dL FVII activity for both rFVIIa and pdFVII. The FVII activity to obtain TG-LT comparable to the upper limit of normal range in healthy controls (4 min) was given by the effective concentration (ECnormal), showing sufficient hemostasis at 3-4 IU/dL FVII activity. No association was seen between FVII activity and other thrombin or plasmin generation parameters as measured by NHA. In conclusion, 3-4 IU/dL FVII activity seems sufficient to maintain hemostasis in patients with severe FVII deficiency during prophylaxis. These data may suggest a potential value for measurement of TG-LT in the monitoring of FVII(a) therapy. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Activation of factor VII bound to tissue factor: A key early step in the tissue factor pathway of blood coagulation

    International Nuclear Information System (INIS)

    Rao, L.V.M.; Rapaport, S.I.

    1988-01-01

    Whether the factor VII/tissue factor complex that forms in tissue factor-dependent blood coagulation must be activated to factor VIIa/tissue factor before it can activate its substrates, factor X and IX, has been a difficult question to answer because the substrates, once activated, back-activate factor VII. The earlier studies suggested that human factor VII/tissue factor cannot activate factor IX. Studies have now been extended to the activation of factor X. Reaction mixtures were made with purified factor VII, X, and tissue factor; in some experiments antithrombin III and heparin were added to prevent back-activation of factor VII. Factor X was activated at similar rates in reaction mixtures containing either VII or factor VIIa after an initial 30-sec lag with factor VII. In reaction mixtures with factor VII a linear activation of factor X was established several minutes before cleavage of 125 I-labeled factor VII to the two-chain activated molecule was demonstrable on gel profiles. These data suggest that factor VII/tissue factor cannot activate measurable amounts of factor X over several minutes. Overall, the results support the hypothesis that a rapid preferential activation of factor VII bound to tissue factor by trace amounts of factor Xa is a key early step in tissue factor-dependent blood coagulation

  1. Targeting Therapy Resistant Tumor Vessels

    Science.gov (United States)

    2008-08-01

    Morris LS. Hysterectomy vs. resectoscopic endometrial ablation for the control of abnormal uterine bleeding . A cost-comparative study. J Reprod Med 1994;39...after the antibody treatment contain a pericyte coat, vessel architecture is normal, the diameter of the vessels is smaller (dilated, abnormal vessels...involvement of proteases from inflammatory mast cells and functionally abnormal (Carmeliet and Jain, 2000; Pasqualini (Coussens et al., 1999) and other bone

  2. The vessel fluence; Fluence cuve

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This book presents the proceedings of the technical meeting on the reactors vessels fluence. They are grouped in eight sessions: the industrial context and the stakes of the vessels control; the organization and the methodology for the fluence computation; the concerned physical properties; the reference computation methods; the fluence monitoring in an industrial context; vessels monitoring under irradiation; others methods in the world; the research and development programs. (A.L.B.)

  3. Americium behaviour in plastic vessels

    International Nuclear Information System (INIS)

    Legarda, F.; Herranz, M.; Idoeta, R.; Abelairas, A.

    2010-01-01

    The adsorption of 241 Am dissolved in water in different plastic storage vessels was determined. Three different plastics were investigated with natural and distilled waters and the retention of 241 Am by these plastics was studied. The same was done by varying vessel agitation time, vessel agitation speed, surface/volume ratio of water in the vessels and water pH. Adsorptions were measured to be between 0% and 70%. The adsorption of 241 Am is minimized with no water agitation, with PET or PVC plastics, and by water acidification.

  4. Americium behaviour in plastic vessels

    Energy Technology Data Exchange (ETDEWEB)

    Legarda, F.; Herranz, M. [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain); Idoeta, R., E-mail: raquel.idoeta@ehu.e [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain); Abelairas, A. [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain)

    2010-07-15

    The adsorption of {sup 241}Am dissolved in water in different plastic storage vessels was determined. Three different plastics were investigated with natural and distilled waters and the retention of {sup 241}Am by these plastics was studied. The same was done by varying vessel agitation time, vessel agitation speed, surface/volume ratio of water in the vessels and water pH. Adsorptions were measured to be between 0% and 70%. The adsorption of {sup 241}Am is minimized with no water agitation, with PET or PVC plastics, and by water acidification.

  5. Americium behaviour in plastic vessels.

    Science.gov (United States)

    Legarda, F; Herranz, M; Idoeta, R; Abelairas, A

    2010-01-01

    The adsorption of (241)Am dissolved in water in different plastic storage vessels was determined. Three different plastics were investigated with natural and distilled waters and the retention of (241)Am by these plastics was studied. The same was done by varying vessel agitation time, vessel agitation speed, surface/volume ratio of water in the vessels and water pH. Adsorptions were measured to be between 0% and 70%. The adsorption of (241)Am is minimized with no water agitation, with PET or PVC plastics, and by water acidification. Copyright 2009 Elsevier Ltd. All rights reserved.

  6. [Large vessel vasculitides].

    Science.gov (United States)

    Morović-Vergles, Jadranka; Puksić, Silva; Gracanin, Ana Gudelj

    2013-01-01

    Large vessel vasculitis includes Giant cell arteritis and Takayasu arteritis. Giant cell arteritis is the most common form of vasculitis affect patients aged 50 years or over. The diagnosis should be considered in older patients who present with new onset of headache, visual disturbance, polymyalgia rheumatica and/or fever unknown cause. Glucocorticoides remain the cornerstone of therapy. Takayasu arteritis is a chronic panarteritis of the aorta ant its major branches presenting commonly in young ages. Although all large arteries can be affected, the aorta, subclavian and carotid arteries are most commonly involved. The most common symptoms included upper extremity claudication, hypertension, pain over the carotid arteries (carotidynia), dizziness and visual disturbances. Early diagnosis and treatment has improved the outcome in patients with TA.

  7. Reactor pressure vessel embrittlement

    International Nuclear Information System (INIS)

    1992-07-01

    Within the framework of the IAEA extrabudgetary programme on the Safety of WWER-440/230 NPPs, a list of safety issues requiring broad studies of generic interest have been agreed upon by an Advisory Group who met in Vienna in September 1990. The list was later revised in the light of the programme findings. The information on the status of the issues, and on the amount of work already completed and under way in the various countries, needs to be compiled. Moreover, an evaluation of what further work is required to resolve each one of the issues is also necessary. In view of this, the IAEA has started the preparation of a series of status reports on the various issues. This report on the generic safety issue ''Reactor Pressure Vessel Embrittlement'' presents a comprehensive survey of technical information available in the field and identifies those aspects which require further investigation. 39 refs, 21 figs, 4 tabs

  8. Reactor containment vessel

    International Nuclear Information System (INIS)

    Ochiai, Kanehiro; Hayagumo, Sunao; Morikawa, Matsuo.

    1981-01-01

    Purpose: To safety and simplify the structure in a reactor containment vessel. Constitution: Steam flow channels with steam jetting ports communicating to coolants are provided between a communication channel and coolants in a pressure suppression chamber. Upon loss of coolant accidents, pressure in a dry well will increase, then force downwards water in an annulus portion and further flow out the water through steam jetting ports into a suppression pool. Thus, the steam flow channel is filled with steams or airs present in the dry well, which are released through the steam jetting ports into the pressure suppression chamber. Even though water is violently vibrated owing to the upward movement of air bubbles and condensation of steam bubbles, the annular portion and the steam jetting ports are filled with steams or the like, direct dynamic loads onto the structures such as communication channels can be avoided. (J.P.N.)

  9. VII National Congress of Spanish Radiotherapy and Oncology Association, Sevilla 20-22 October 1993 Abstracts

    International Nuclear Information System (INIS)

    1993-01-01

    This special issue of Oncology Journal presents the 142 abstracts of VII National Congress of Spanish Radiotherapy and Oncology Association. The lectures were distributed into 3 groups: a) Radiochemotherapy b) Lymphoma c) Paliative radiotherapy and quality of life

  10. Reaction of Pu(VII) with certain aliphatic alcohols in basic media

    International Nuclear Information System (INIS)

    Tananaev, I.G.

    1992-01-01

    The kinetics of Pu(VII) reduction by methanol and ethanol in 0.5-5.0 M NaOH are studied by spectrophotometry. The rate constants of the studied reactions are calculated. The rate constants increase in concert with the reductant concentration but sharply decrease with increasing base concentration in the reaction medium. The principal factor affecting the rate of Pu(VII) reduction by alcohols is probably steric in nature. Secondary alcohols are more active in basic medium. The resulting experimental data also confirm the very strong oxidizing capability of Pu(VII), the rate of reduction of which by CH 3 OH or C 2 H 5 OH compared with Np(VII) under similar conditions is 20-50 times faster

  11. Vehicle infrastructure integration (VII) based road-condition warning system for highway collision prevention.

    Science.gov (United States)

    2009-05-01

    As a major ITS initiative, the Vehicle Infrastructure Integration (VII) program is to revolutionize : transportation by creating an enabling communication infrastructure that will open up a wide range of : safety applications. The road-condition warn...

  12. Biological and phylogenetic characterization of a genotype VII Newcastle disease virus from Venezuela: Efficacy of vaccination

    Science.gov (United States)

    Here we describe the characterization a virulent genotype VII Newcastle disease virus (NDV) from Venezuela and evaluate the efficacy of heterologous genotype commercial vaccination under field and controlled rearing conditions. Biological pathotyping and molecular analysis were applied. Results sh...

  13. Viis raamatutäit poola näidendeid / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2006-01-01

    Tõlkija Hendrik Lindepuult ilmus viies tõlkekogumik poola dramaturgia tippteoseid tutvustavast sarjast. Seekord said kaante vahele Tadeusz Rozewiczi näidendid "Valge abielu", "Lõks" ja "Vana naine haub"

  14. The Financial Regulations of the Agency. Amendment of Articles V, VI and VII

    International Nuclear Information System (INIS)

    1960-01-01

    On 13 January 1960 the Board of Governors made certain changes in Articles V, VI and VII of the Financial Regulations. The Articles thus amended are reproduced in this document for the information of all Members of the Agency

  15. The Financial Regulations of the Agency. Amendment of Articles V, VI and VII

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1960-03-24

    On 13 January 1960 the Board of Governors made certain changes in Articles V, VI and VII of the Financial Regulations. The Articles thus amended are reproduced in this document for the information of all Members of the Agency.

  16. Treatment of lysosomal storage disease in MPS VII mice using a recombinant adeno-associated virus.

    Science.gov (United States)

    Watson, G L; Sayles, J N; Chen, C; Elliger, S S; Elliger, C A; Raju, N R; Kurtzman, G J; Podsakoff, G M

    1998-12-01

    Mucopolysaccharidosis type VII (MPS VII) is a lysosomal storage disease caused by a genetic deficiency of beta-glucuronidase (GUS). We used a recombinant adeno-associated virus vector (AAV-GUS) to deliver GUS cDNA to MPS VII mice. The route of vector administration had a dramatic effect on the extent and distribution of GUS activity. Intramuscular injection of AAV-GUS resulted in high, localized production of GUS, while intravenous administration produced low GUS activity in several tissues. This latter treatment of MPS VII mice reduced glycosaminoglycan levels in the liver to normal and reduced storage granules dramatically. We show that a single administration of AAV-GUS can provide sustained expression of GUS in a variety of cell types and is sufficient to reverse the disease phenotype at least in the liver.

  17. Application of material databases for improved reliability of reactor pressure vessels

    International Nuclear Information System (INIS)

    Griesbach, T.J.; Server, W.L.; Beaudoin, B.F.; Burgos, B.N.

    1994-01-01

    A vital part of reactor vessel Life Cycle Management program must begin with an accurate characterization of the vessel material properties. Uncertainties in vessel material properties or use of bounding values may result in unnecessary conservatisms in vessel integrity calculations. These conservatisms may be eliminated through a better understanding of the material properties in reactor vessels, both in the unirradiated and irradiated conditions. Reactor vessel material databases are available for quantifying the chemistry and Charpy shift behavior of individual heats of reactor vessel materials. Application of the databases for vessels with embrittlement concerns has proven to be an effective embrittlement management tool. This paper presents details of database development and applications which demonstrate the value of using material databases for improving material chemistry and for maximizing the data from integrated material surveillance programs

  18. The Freedom to Believe and the Freedom to Practice: Title VII, Muslim Women, and Hijab

    OpenAIRE

    Benson, Kristina

    2014-01-01

    Although Title VII of the Civil Rights Act nominally affirmed employees’ right to wear hijab in the workplace, the courts have taken an increasingly narrow view of the term “religion” and failed to uphold the right to wear hijab in both private and public sector settings on several occasions. This is because Title VII and its attendant protections are grounded in a framework that presumes Christianity as normative, and religiously mandated accoutrements as communicative in function. The manne...

  19. Pengaruh Penerapan Pembelajaran Arias Dipadu Mind Map terhadap Hasil Belajar Kognitif Siswa Kelas VII

    OpenAIRE

    Leliavia, Leliavia; Al Muhdhar, Mimien Henie Irawati; Suwono, Hadi

    2017-01-01

    This research was to determine the effect of differences ARIAS combined mind map learning and ARIAS learning to cognitive learning outcomes grade VII SMPN 1 Tempunak. This research with quasy research experiment design approach with the design of pretest-posttest. Data were analyzed using descriptive statistics and inferensial to test the hypothesis that analysis of covariance (ANCOVA) using SPSS 23 for windows with a significance level of 0,05. The study was conducted at the grade VII SMPN 1...

  20. PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH DAN PENGEMBANGAN KARAKTER PADA SISWA KELAS VII MELALUI MODEL PBL BERBANTUAN SCAFFOLDING

    OpenAIRE

    Novy Kris Zaini; Wuryanto Wuryanto; Hery Sutarto

    2016-01-01

    Tujuan penelitian ini adalah untuk mengetahui (1) apakah kemampuan pemecahan masalah matematika peserta didik yang diajar dengan model PBL berbantuan scaffolding pada materi pokok segiempat kelas VII dapat mencapai KKM yang ditetapkan, (2) apakah pembelajaran matematika dengan model PBL berbantuan scaffolding pada materi pokok segiempat kelas VII dapat meningkatkan kemampuan pemecahan masalah peserta didik pilihan, (3) apakah pembelajaran matematika dengan model PBL berbantuan scaffolding pad...

  1. Addition to the analysis of the Sr VI and Sr VII spectra

    International Nuclear Information System (INIS)

    Wyart, J.F.

    1989-01-01

    Fifty-six lines of multicharged strontium are measured with an improved wavelength accuracy, or interpreted for the first time. They are 4p-4s, 4p-5s and 4p-4d transitions in Sr VII and 4p-5s transitions in Sr VI. The revision of the singlet-triplet connection in Sr VII is supported by theoretical survey of the ground configuration in Ge-like ions. (orig.)

  2. Shear strength of end slabs of prestressed concrete nuclear reactor vessels

    International Nuclear Information System (INIS)

    Reins, J.D.; Quiros, J.L. Jr.; Schnobrich, W.C.; Sozen, M.A.

    1976-07-01

    The report summarizes the experimental and part of the analytical work carried out in connection with an investigation of the structural strength of prestressed concrete reactor vessels. The project is part of the Prestressed Concrete Reactor Vessel Program of the Oak Ridge National Laboratory sponsored by ERDA. The objective of the current phase of the work is to develop procedures to determine the shear strength of flat end slabs of reactor vessels with penetrations

  3. Assessment of the TRINO reactor pressure vessel integrity: theoretical analysis and NDE

    Energy Technology Data Exchange (ETDEWEB)

    Milella, P P; Pini, A [ENEA, Rome (Italy)

    1988-12-31

    This document presents the method used for the capability assessment of the Trino reactor pressure vessel. The vessel integrity assessment is divided into the following parts: transients evaluation and selection, fluence estimate for the projected end of life of the vessel, characterization of unirradiated and irradiated materials, thermal and stress analysis, fracture mechanics analysis and eventually fracture input to Non Destructive Examination (NDE). For each part, results are provided. (TEC).

  4. ENDF/B-VII.0: Next Generation Evaluated Nuclear Data Library for Nuclear Science and Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chadwick, M B; Oblozinsky, P; Herman, M; Greene, N M; McKnight, R D; Smith, D L; Young, P G; MacFarlane, R E; Hale, G M; Haight, R C; Frankle, S; Kahler, A C; Kawano, T; Little, R C; Madland, D G; Moller, P; Mosteller, R; Page, P; Talou, P; Trellue, H; White, M; Wilson, W B; Arcilla, R; Dunford, C L; Mughabghab, S F; Pritychenko, B; Rochman, D; Sonzogni, A A; Lubitz, C; Trumbull, T H; Weinman, J; Brown, D; Cullen, D E; Heinrichs, D; McNabb, D; Derrien, H; Dunn, M; Larson, N M; Leal, L C; Carlson, A D; Block, R C; Briggs, B; Cheng, E; Huria, H; Kozier, K; Courcelle, A; Pronyaev, V; der Marck, S

    2006-10-02

    biases in fast systems are largely removed; (c) ENDF/B-VI.8 good agreement for simulations of highly enriched uranium assemblies is preserved; (d) The underprediction of fast criticality of {sup 233,235}U and {sup 239}Pu assemblies is removed; and (e) The intermediate spectrum critical assemblies are predicted more accurately. We anticipate that the new library will play an important role in nuclear technology applications, including transport simulations supporting national security, nonproliferation, advanced reactor and fuel cycle concepts, criticality safety, medicine, space applications, nuclear astrophysics, and nuclear physics facility design. The ENDF/B-VII.0 library is archived at the National Nuclear Data Center, BNL. The complete library, or any part of it, may be retrieved from www.nndc.bnl.gov.

  5. Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells.

    Science.gov (United States)

    Yokota, N; Koizume, S; Miyagi, E; Hirahara, F; Nakamura, Y; Kikuchi, K; Ruf, W; Sakuma, Y; Tsuchiya, E; Miyagi, Y

    2009-12-15

    Thromboembolic events are a major complication in ovarian cancer patients. Tissue factor (TF) is frequently overexpressed in ovarian cancer tissue and correlates with intravascular thrombosis. TF binds to coagulation factor VII (fVII), changing it to its active form, fVIIa. This leads to activation of the extrinsic coagulation cascade. fVII is produced by the liver and believed to be supplied from blood plasma at the site of coagulation. However, we recently showed that ovarian cancer cells express fVII transcripts under normoxia and that this transcription is inducible under hypoxia. These findings led us to hypothesise that ovarian cancer cells are intrinsically associated with TF-fVIIa coagulation activity, which could result in thrombosis. In this study, we examined whether ectopically expressed fVII could cause thrombosis by means of immunohistochemistry, RT-PCR, western blotting and flow cytometry. Ectopic fVII expression occurs frequently in ovarian cancers, particularly in clear cell carcinoma. We further showed that ovarian cancer cells express TF-fVIIa on the cell surface under normoxia and that this procoagulant activity is enhanced by hypoxic stimuli. Moreover, we showed that ovarian cancer cells secrete microparticles (MPs) with TF-fVIIa activity. Production of this procoagulant secretion is enhanced under hypoxia. These results raise the possibility that cancer cell-derived TF-fVIIa could cause thrombotic events in ovarian cancer patients.

  6. GANGGUAN CEMAS PADA MAHASISWA SEMESTER I DAN VII PROGRAM STUDI PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA

    Directory of Open Access Journals (Sweden)

    Dyah Chandratika

    2015-05-01

    Full Text Available Penting untuk dilakukan penelitian mengenai gangguan cemas pada mahasiswa kedokteran karena tingginya tingkat stres mahasiswa terutama pada tahun pertama perkuliahan. Tujuan penelitian ini adalah untuk mengetahui prevalensi dan perbedaan skor  gangguan  cemas  pada mahasiswa  semester  I dan  VII serta untuk  mengetahui perbedaan skor gangguan cemas antara mahasiswa laki-laki dan perempuan di Fakultas Kedokteran Universitas Udayana. Desain penelitian ini adalah cross sectional analitik. Pengambilan sampel dilakukan secara random sampling. Sampel mengisi identitas, kuesioner L-MMPI, kuesioner Hamilton Anxiety Rating Scale (HARS. Kemudian dihitung prevalensi gangguan cemas tiap kelompok serta data dianalisis menggunakan uji t-independen. Terdapat 15 orang (25,0% mahasiswa semester I dan 7 orang (11,7% mahasiswa semester VII yang mengalami gangguan cemas. Dari hasil uji t-independen antara skor gangguan cemas mahasiswa semester I dan VII diperoleh nilai p = 0,001 (<0,05. Sedangkan diperoleh p = 0,080 antara mahasiswa laki-laki dan perempuan pada semester I dan p = 0,744 antara mahasiswa laki-laki dan perempuan pada semester VII. Prevalensi gangguan cemas pada mahasiswa semester I yaitu 25,0% sedangkan 11,7% pada mahasiswa semester VII. Terdapat perbedaan bermakna antara skor gangguan cemas mahasiswa semester I dan VII. Tidak ditemukan perbedaan bermakna skor gangguan cemas antara laki-laki dan perempuan.   

  7. Structural incorporation of MgCl2 into ice VII at room temperature

    Science.gov (United States)

    Watanabe, Mao; Komatsu, Kazuki; Noritake, Fumiya; Kagi, Hiroyuki

    2017-05-01

    Raman spectra and X-ray diffraction patterns were obtained from 1:100 and 1:200 \\text{MgCl}2:\\text{H}2\\text{O} solutions (in molar ratio) at pressures up to 6 GPa using diamond anvil cells (DACs) and compared with those of pure water. The O-H stretching band from ice VII crystallized from the 1:200 solution was approximately 10 cm-1 higher than that of pure ice VII. The phase boundaries between ice VII and VIII crystallized from the MgCl2 solutions at 4 GPa were 2 K lower than those of pure ice VII and VIII. These observations indicate that ice VII incorporates MgCl2 into its structure. The unit cell volumes of ice VII crystallized from pure water and the two solutions coincided with each other within the experimental error, and salt incorporation was not detectable from the cell volume. Possible configurations of ion substitution and excess volume of ice VIII were simulated on the basis of density functional theory (DFT) calculations.

  8. Chronic sleep deprivation markedly reduces coagulation factor VII expression

    Science.gov (United States)

    Pinotti, Mirko; Bertolucci, Cristiano; Frigato, Elena; Branchini, Alessio; Cavallari, Nicola; Baba, Kenkichi; Contreras-Alcantara, Susana; Ehlen, J. Christopher; Bernardi, Francesco; Paul, Ketema N.; Tosini, Gianluca

    2010-01-01

    Chronic sleep loss, a common feature of human life in industrialized countries, is associated to cardiovascular disorders. Variations in functional parameters of coagulation might contribute to explain this relationship. By exploiting the mouse model and a specifically designed protocol, we demonstrated that seven days of partial sleep deprivation significantly decreases (−30.5%) the thrombin generation potential in plasma evaluated upon extrinsic (TF/FVIIa pathway) but not intrinsic activation of coagulation. This variation was consistent with a decrease (−49.8%) in the plasma activity levels of factor VII (FVII), the crucial physiologicalal trigger of coagulation, which was even more pronounced at the liver mRNA level (−85.7%). The recovery in normal sleep conditions for three days completely restored thrombin generation and FVII activity in plasma. For the first time, we demonstrate that chronic sleep deprivation on its own reduces, in a reversible manner, the FVII expression levels, thus influencing the TF/FVIIa activation pathway efficiency. PMID:20418241

  9. Recombinant activated factor VII: 30 years of research and innovation.

    Science.gov (United States)

    Hedner, Ulla

    2015-06-01

    Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital haemophilia and inhibitors. The story of its development began in the 1970s, when FVIIa was identified as one of the activated coagulation factors that has minimal potential for inducing thromboembolic side-effects. Extensive research over the last 30 years has greatly increased our knowledge of the characteristics of FVII, its activation, and the mechanisms by which rFVIIa restores haemostasis. In haemophilia, the haemostatic effect of rFVIIa is mediated via binding to thrombin-activated platelets at the site of injury, thereby enhancing thrombin generation also in the absence of factor (F) VIII or FIX. The mechanism of action of rFVIIa has also allowed its successful use in other clinical scenarios characterised by impaired thrombin generation, and its licensed uses have now been extended to acquired haemophilia, congenital FVII deficiency and Glanzmann's thrombasthenia. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. United Nations Charter, Chapter VII, Article 43: Now or Never.

    Science.gov (United States)

    Burkle, Frederick M

    2018-04-25

    For more than 75 years, the United Nations Charter has functioned without the benefit of Chapter VII, Article 43, which commits all United Nations member states "to make available to the Security Council, on its call, armed forces, assistance, facilities, including rights of passage necessary for the purpose of maintaining international peace and security." The consequences imposed by this 1945 decision have had a dramatic negative impact on the United Nation's functional capacity as a global body for peace and security. This article summarizes the struggle to implement Article 43 over the decades from the onset of the Cold War, through diplomatic attempts during the post-Cold War era, to current and often controversial attempts to provide some semblance of conflict containment through peace enforcement missions. The rapid growth of globalization and the capability of many nations to provide democratic protections to their populations are again threatened by superpower hegemony and the development of novel unconventional global threats. The survival of the United Nations requires many long overdue organizational structure and governance power reforms, including implementation of a robust United Nations Standing Task Force under Article 43. (Disaster Med Public Health Preparedness. 2018;page 1 of 8).

  11. Irradiation embrittlement of pressure vessel steels

    International Nuclear Information System (INIS)

    Brumovsky, M.; Vacek, M.

    1975-01-01

    A Standard Research Programme on Irradiation Embrittlement of Pressure Vessel Steels was approved by the Coordinating Meeting on the 12th May 1972 at the Working Group on Engineering Aspects of Irradiation Embrittlement of Pressure Vessel Steels. This Working Group was set up by the International Atomic Energy Agency in Vienna. Seven countries with their research institutes agreed on doing irradiation experiments according to the approved programme on steel A533 B from the U.S. HSST Programme. The Czechoslovak contribution covering tensile and impact testing of non-irradiated steel and steel irradiated at 280degC to 1.3 x 10 23 n/m 2 (E above 1 MeV) is presented in this report. As an additional part the same set of experiments was carried out on two additional steels - A 542 and A 543, made in SKODA Works for comparison of their irradiation embrittlement and hardening with A533 B steel. (author)

  12. Large deletions play a minor but essential role in congenital coagulation factor VII and X deficiencies.

    Science.gov (United States)

    Rath, M; Najm, J; Sirb, H; Kentouche, K; Dufke, A; Pauli, S; Hackmann, K; Liehr, T; Hübner, C A; Felbor, U

    2015-01-01

    Congenital factor VII (FVII) and factor X (FX) deficiencies belong to the group of rare bleeding disorders which may occur in separate or combined forms since both the F7 and F10 genes are located in close proximity on the distal long arm of chromosome 13 (13q34). We here present data of 192 consecutive index cases with FVII and/or FX deficiency. 10 novel and 53 recurrent sequence alterations were identified in the F7 gene and 5 novel as well as 11 recurrent in the F10 gene including one homozygous 4.35 kb deletion within F7 (c.64+430_131-6delinsTCGTAA) and three large heterozygous deletions involving both the F7 and F10 genes. One of the latter proved to be cytogenetically visible as a chromosome 13q34 deletion and associated with agenesis of the corpus callosum and psychomotor retardation. Large deletions play a minor but essential role in the mutational spectrum of the F7 and F10 genes. Copy number analyses (e. g. MLPA) should be considered if sequencing cannot clarify the underlying reason of an observed coagulopathy. Of note, in cases of combined FVII/FX deficiency, a deletion of the two contiguous genes might be part of a larger chromosomal rearrangement.

  13. THE EVALUATION OF BSE BAHASA INGGRIS FOR GRADE VII: WHEN ENGLISH RINGS A BELL

    Directory of Open Access Journals (Sweden)

    Doddy Dwi Wahyuwono

    2017-12-01

    Full Text Available Coursebooks are core parts of any curriculum as the unique contributors to content learning (Demir & Ertas, 2014. Currently, in Indonesian curriculum, K13, the government develops coursebooks that can be used by students nationally. The developed coursebooks, Buku Sekolah Elektronik (BSE, vary for different level of education, starting from elementary schools up to senior and vocational high schools. In developing the coursebooks, the government needs to implement the coursebooks to the real life situation and also evaluate them. In this paper, the researchers try to evaluate a coursebook used in English class for Junior High School students grade VII. The evaluation is done through two ways, the theory-based analysis and checklist-based analysis. The used evaluative theories are made by Cunningsworth and the Checklist is made by Mukundan, Nimehchisalem, and Hajimohammadi. The findings show that the coursebook has met the requirements of learners‘ needs stated in the K13; however, there are still some aspects that can use some further improvement, such as the design, materials‘ authenticity, and so on. Ergo, in corresponding to the findings, the suggestions can be given to two parties, the developers and the teachers. The developers are hoped to take the evaluation results into account as the crucial points for future improvement and the teachers are hoped to not solely depend on the coursebook itself, but creatively look for extra materials.

  14. Pressure vessel for nuclear reactors

    International Nuclear Information System (INIS)

    1975-01-01

    The invention applies to a pressure vessel for nuclear reactors whose shell, made of cast metal segments, has a steel liner. This liner must be constructed to withstand all operational stresses and to be easily repairable. The invention solves this problem by installing the liner at a certain distance from the inner wall of the pressure vessel shell and by filling this clearance with supporting concrete. Both the concrete and the steel liner must have a lower prestress than the pressure vessel shell. In order to avoid damage to the liner when prestressing the pressure vessel shell, special connecting elements are provided which consist of welded-on fastening elements projecting into recesses in the cast metal segments of the pressure vessel. Their design is described in detail. (TK) [de

  15. 77 FR 59575 - Hull Identification Numbers for Recreational Vessels

    Science.gov (United States)

    2012-09-28

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 181 [Docket No. USCG-2012-0843] Hull Identification Numbers for Recreational Vessels AGENCY: Coast Guard, DHS. ACTION: Request for public comments... requirement to indicate a boat's model year as part of the 12-character Hull Identification Number (HIN...

  16. Influence of small towns on the lichen vegetation. Part VII. Discussion and general conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Rydzak, J

    1958-01-01

    The problem of poverty of lichen vegetation in large or industrial towns was raised in 1866. Since then several large European cities have been studied and there were described zones of gradual impoverishment of lichen flora from the outskirts to the centre of the town. The zones are: (1) Zone of normally developed flora at the outskirts of the town. (2) Struggle zone which is a more or less extensive area with scattered houses and which surrounds the crowded central quarters. In this zone scanty specimens of a few lichen species were found; their thalli were contracted, under-developed, as if fighting for life in unfavorable environmental conditions. (3) Lichen-free zone, lichen desert, which comprises the centre of the town and its industrial quarters; no lichens could be found there. The results of these investigations strengthened the belief that lichens are organisms very sensitive to the action of substances formed during coal combustion in town. Sulphur dioxide (SO/sub 2/) was believed to be especially harmful to lichens, causing their death even in trace concentrations.

  17. Part II. Chapter VII. Lack of knowledge has generated misconceptions about WWER in Western Europe

    International Nuclear Information System (INIS)

    Bucha, T.

    2008-01-01

    In this interview Mr. Giancarlo Aquilanti (Project Director Mochovce NPP, Unit-3 and Unit-4, the Slovenske elektrarne, a. s., a member of ENEL) evaluates reactor safety in Mochovce NPP. Perspectives of development of nuclear energy in the Slovak Republic and Italia are discussed.

  18. 40 CFR Appendix Vii to Part 261 - Basis for Listing Hazardous Waste

    Science.gov (United States)

    2010-07-01

    ..., acetonitrile, hydrocyanic acid. K013 Hydrocyanic acid, acrylonitrile, acetonitrile. K014 Acetonitrile..., trichlorofluoromethane. F003 N.A. F004 Cresols and cresylic acid, nitrobenzene. F005 Toluene, methyl ethyl ketone, carbon... -tetrachlorophenols and their chlorophenoxy derivative acids, esters, ethers, amine and other salts. F021 Penta- and...

  19. Containment vessel stability analysis

    International Nuclear Information System (INIS)

    Harstead, G.A.; Morris, N.F.; Unsal, A.I.

    1983-01-01

    The stability analysis for a steel containment shell is presented herein. The containment is a freestanding shell consisting of a vertical cylinder with a hemispherical dome. It is stiffened by large ring stiffeners and relatively small longitudinal stiffeners. The containment vessel is subjected to both static and dynamic loads which can cause buckling. These loads must be combined prior to their use in a stability analysis. The buckling loads were computed with the aid of the ASME Code case N-284 used in conjunction with general purpose computer codes and in-house programs. The equations contained in the Code case were used to compute the knockdown factors due to shell imperfections. After these knockdown factors were applied to the critical stress states determined by freezing the maximum dynamic stresses and combining them with other static stresses, a linear bifurcation analysis was carried out with the aid of the BOSOR4 program. Since the containment shell contained large penetrations, the Code case had to be supplemented by a local buckling analysis of the shell area surrounding the largest penetration. This analysis was carried out with the aid of the NASTRAN program. Although the factor of safety against buckling obtained in this analysis was satisfactory, it is claimed that the use of the Code case knockdown factors are unduly conservative when applied to the analysis of buckling around penetrations. (orig.)

  20. Pressure vessel design

    International Nuclear Information System (INIS)

    Annaratone, D.

    2007-01-01

    This book guides through general and fundamental problems of pressure vessel design. It moreover considers problems which seem to be of lower importance but which turn out to be crucial in the design phase. The basic approach is rigorously scientific with a complete theoretical development of the topics treated, but the analysis is always pushed so far as to offer concrete and precise calculation criteria that can be immediately applied to actual designs. This is accomplished through appropriate algorithms that lead to final equations or to characteristic parameters defined through mathematical equations. The first chapter describes how to achieve verification criteria, the second analyzes a few general problems, such as stresses of the membrane in revolution solids and edge effects. The third chapter deals with cylinders under pressure from the inside, while the fourth focuses on cylinders under pressure from the outside. The fifth chapter covers spheres, and the sixth is about all types of heads. Chapter seven discusses different components of particular shape as well as pipes, with special attention to flanges. The eighth chapter discusses the influence of holes, while the ninth is devoted to the influence of supports. Finally, chapter ten illustrates the fundamental criteria regarding fatigue analysis. Besides the unique approach to the entire work, original contributions can be found in most chapters, thanks to the author's numerous publications on the topic and to studies performed ad hoc for this book. (orig.)

  1. Nuclear reactor installation with outer shell enclosing a primary pressure vessel

    International Nuclear Information System (INIS)

    1975-01-01

    The high temperature nuclear reactor installation described includes a fluid cooled nuclear heat source, a primary pressure vessel containing the heat source, an outer shell enclosing the primary pressure vessel and acting as a secondary means of containment for this vessel against outside projectiles. Multiple auxiliary equipment points are arranged outside the outer shell which comprises a part of a lower wall around the primary pressure vessel, an annular part integrated in the lower wall and extending outwards as from this wall and an upper part integrated in the annular part and extending above this annular part and above the primary pressure vessel. The annular part and the primary pressure vessel are formed with vertical penetrations which can be closed communicating respectively with the auxiliary equipment points and with inside the pressure vessel whilst handling gear is provided in the upper part for vertically raising reactor components through these penetrations and for transporting them over the annular part and over the primary pressure vessel [fr

  2. Limit analysis and design of containment vessels

    International Nuclear Information System (INIS)

    Save, M.

    1984-01-01

    In the introduction, the theory of plastic analysis of shells is briefly recalled. Minimum-volume design for assigned load factor at plastic collapse is then considered and optimality criteria are derived for plates and shells of continuously varying or piecewise-constant thickness. In the first part, containers made of metal are examined. Analytical and numerical limit analysis solutions and corresponding experimental results are considered for various types of vessels, including intersecting shells. Attention is given to experimental post-yield behavior. Some tests up to fracture are discussed. New theoretical and experimental results of limit analysis of stiffened cylindrical vessels are presented, in which reinforcing rings are treated as discrete structural element (no smearing out) and due account is taken of their strong curvature. Cases of collapse by instability under internal pressure are pointed out. Minimum-volume design of circular plates and cylindrical shells is then formulated and various examples are presented of sandwich and solid metal structures. Containers of piecewise-constant thickness are given particular attention. Available experimental evidence on minimum-volume design of plates and shells is reviewed and commented upon. The second part deals with reinforced concrete vessels. Cylindrical containers are studied, from both points of view of limit analysis and of limit design with minimum volume of reinforcement. The practical use of the latter solutions is discussed. A third part reviews other loading cases (including cyclic and impact loads) and gives indications on corresponding theories, formulations and solution methods. The last part is devoted to a discussion of the limitations of the methods presented, within the frame of the 'limit states' design philosophy, which is first briefly recalled. Considerations on further research in the field conclude the paper. (orig.)

  3. Isotypic analysis of antibodies against activated Factor VII in patients with Factor VII deficiency using the x-MAP technology.

    Science.gov (United States)

    Pfeiffer, Caroline; Mathieu-Dupas, Eve; Logghe, Pauline; Lissalde-Lavigne, Géraldine; Balicchi, Julien; Caliskan, Umran; Valentin, Thomas; Laune, Daniel; Molina, Franck; Schved, Jean François; Giansily-Blaizot, Muriel

    2016-05-01

    While the immune response to hemophilic factors in hemophilia has been widely studied, little is known about the development of anti-Factor VII (FVII) antibodies in FVII deficiency. We developed a robust technique based on the x-MAP technology to detect the presence of antibodies against FVII and characterize their isotype and validated this method using blood samples from 100 patients with FVII deficiency (median FVII clotting activity [FVII:C]: 6%) and 95 healthy controls. Anti-FVII antibodies were detected in patients but also in some controls, although the concentration of total immunoglobulin G (IgGt) and IgG1 and IgG4 subclasses was significantly different between groups. The IgG1 subclass concentrations remained significantly different also when only untreated patients were compared with controls. This difference could partially be related to the F7 genotype, particularly in patients harboring the p.Arg139Gln mutation. This x-MAP-based method might be useful for assessing the immunogenicity of novel FVII compounds and of activated FVII (FVIIa) concentrates. Further prospective studies are needed to better understand the clinical relevance of these antibodies in the management of patients with FVII deficiency. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Mutation in the factor VII hepatocyte nuclear factor 4α-binding site contributes to factor VII deficiency.

    Science.gov (United States)

    Zheng, Xing-Wu; Kudaravalli, Rama; Russell, Theresa T; DiMichele, Donna M; Gibb, Constance; Russell, J Eric; Margaritis, Paris; Pollak, Eleanor S

    2011-10-01

    Severe coagulant factor VII (FVII) deficiency in postpubertal dizygotic twin males results from two point mutations in the FVII gene, a promoter region T→C transition at -60 and a His-to-Arg substitution at amino acid 348; both mutations prevent persistence of plasma functional FVII. This report documents longitudinal laboratory measurements from infancy to adulthood of FVII coagulant activity (FVII:C) in the twin FVII-deficient patients; it also details specific biochemical analyses of the -60 T→C mutation. The results revealed FVII:C levels of less than 1% in infancy that remain severely decreased through puberty and into adulthood. In-vitro analyses utilizing hepatocyte nuclear factor 4α (HNF4α) co-transfection and a chromatin immunoprecipitation assay indicate that the -60 T→C mutation severely diminishes functional interaction between the FVII promoter and transcription factor HNF4α. The importance of interaction between the FVII gene and HNF4α in normal FVII expression provides an in-vivo illustration of the regulated expression of an autosomal gene encoding a coagulation protein. The constancy of FVII:C and peripubertal patient symptomatology reported here illustrates androgen-independent expression in contrast to expression with an analogous mutation in the promoter region of the gene encoding coagulation FIX.

  5. A comparison between recombinant activated factor VII (Aryoseven) and Novoseven in patients with congenital factor VII deficiency.

    Science.gov (United States)

    Faranoush, M; Abolghasemi, Hassan; Toogeh, Gh; Karimi, M; Eshghi, P; Managhchi, M; Hoorfar, H; Dehdezi, B Keikhaei; Mehrvar, A; Khoeiny, B; Kamyar, K; Heshmat, R; Baghaeipour, M R; Mirbehbahani, N B; Fayazfar, R; Ahmadinejad, M; Naderi, M

    2015-11-01

    In order to establish the efficacy and biosimilar nature of AryoSeven to NovoSeven in the treatment of congenital factor VII (FVII) deficiency, patients received either agent at 30 μg/kg, intravenously per week for 4 weeks, in a randomized fashion. The primary aim was to compare FVII:coagulation activity (FVII:C), 20 minutes after recombinant activated FVII (rFVIIa) injection, in the 2 groups. A secondary measure was self-reported bleeding. The median interquartile baseline range of the plasma level of activated FVII (FVIIa) activity in the 2 groups was 1.6 (1.1-14.0) IU/dL and 5.0 (1.1-25.5) IU/dL. All patients achieved levels of FVIIa (FVII:C) >30 IU/dL, 20 minutes after the injection of rFVIIa. Bleeding was similar between the 2 groups, with a comparable decrease in severity and frequency compared to the last month prior to treatment. AryoSeven is similar to NovoSeven in increasing postinjection FVIIa activity as well as in clinical safety and efficacy. © The Author(s) 2014.

  6. PWR vessel flaw distribution development

    International Nuclear Information System (INIS)

    Rosinski, S.T.; Kennedy, E.L.; Foulds, J.R.; Kinsman, K.M.

    1990-01-01

    This paper reports on PWR pressure vessels which operate under NRC rules and regulatory guides intended to prevent failure of the vessels. Plants failing to meet the operating criteria specified under these rules and regulations are required to analytically demonstrate fitness for service in order to continue operation. The initial flaw size or distribution of initial vessel flaws is a key input to the required vessel integrity analyses. However, the flaw distribution assumed in the development of the NRC Regulations and recommended for the plant specific analyses is potentially over-conservative. This is because the distribution is based on the limited amount of vessel inspection data available at the time the criteria were being developed and does not take full advantage of the more recent and reliable domestic vessel inspection results. The U.S. Department of Energy is funding an effort through Sandia National Laboratories to investigate the possibility of developing a new flaw distribution based on the increased amount and improved reliability of domestic vessel inspection data. Results of Phase I of the program indicate that state-of-the-art NDE systems' capabilities are sufficient for development of a new flaw distribution that could ultimately provide life extension benefits over the presently required operating practice

  7. Nuclear reactor vessel decontamination systems

    International Nuclear Information System (INIS)

    McGuire, P. J.

    1985-01-01

    There is disclosed in the present application, a decontamination system for reactor vessels. The system is operatable without entry by personnel into the contaminated vessel before the decontamination operation is carried out and comprises an assembly which is introduced into the vertical cylindrical vessel of the typical boiling water reactor through the open top. The assembly includes a circular track which is centered by guideways permanently installed in the reactor vessel and the track guides opposed pairs of nozzles through which water under very high pressure is directed at the wall for progressively cutting and sweeping a tenacious radioactive coating as the nozzles are driven around the track in close proximity to the vessel wall. The whole assembly is hoisted to a level above the top of the vessel by a crane, outboard slides on the assembly brought into engagement with the permanent guideways and the assembly progressively lowered in the vessel as the decontamination operation progresses. The assembly also includes a low pressure nozzle which forms a spray umbrella above the high pressure nozzles to contain radioactive particles dislodged during the decontamination

  8. Dietary changes in fasting levels of factor VII coagulant activity (FVII:C) are accompanied by changes in factor VII protein and other vitamin K-dependent proteins

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Tholstrup, T; Marckmann, P

    1995-01-01

    The mechanisms behind dietary effects on fasting coagulant activity of factor VII (FVII:C) are not clarified. In the present study of 15 young volunteers, two experimental diets differing in composition of saturated fatty acids (C18:0 [diet S] or C12:0 + C14:0 [diet ML]) were served for 3 weeks...

  9. Gammatography of thick lead vessels

    International Nuclear Information System (INIS)

    Raghunath, V.M.; Bhatnagar, P.K.; Sundaram, V.M.

    1979-01-01

    Radiography, scintillation and GM counting and dose measurements using ionisation chamber equipment are commonly used for detecting flaws/voids in materials. The first method is mostly used for steel vessels and to a lesser extent thin lead vessels also and is essentially qualitative. Dose measuring techniques are used for very thick and large lead vessels for which high strength radioactive sources are required, with its inherent handling problems. For vessels of intermediate thicknesses, it is ideal to use a small strength source and a GM or scintillation counter assembly. At the Reactor Research Centre, Kalpakkam, such a system was used for checking three lead vessels of thicknesses varying from 38mm to 65mm. The tolerances specified were +- 4% variation in lead thickness. The measurements also revealed the non concentricity of one vessel which had a thickness varying from 38mm to 44mm. The second vessel was patently non-concentric and the dimensional variation was truly reproduced in the measurements. A third vessel was fabricated with careful control of dimensions and the measurements exhibited good concentricity. Small deviations were observed, attributable to imperfect bondings between steel and lead. This technique has the following advantages: (a) weaker sources used result in less handling problems reducing the personnel exposures considerably; (b) the sensitivity of the instrument is quite good because of better statistics; (c) the time required for scanning a small vessel is more, but a judicious use of a scintillometer for initial fast scan will help in reducing the total scanning time; (d) this method can take advantage of the dimensional variations themselves to get the calibration and to estimate the deviations from specified tolerances. (auth.)

  10. In-vessel core debris retention experiments. Final report

    International Nuclear Information System (INIS)

    1998-10-01

    The in-vessel cooling experimental program (Phase 1 and 2) was motivated by the survivability of the TMI lower vessel head during the TMI-2 accident. During that accident, molten debris relocation into the water filled lower head resulted in a localized hot spot in the lower head, but no lower head failure occurred. A postulated set of mechanisms which could be involved in and responsible for the survivability of the TMI lower head were identified and experimentally investigated as part of this program. These mechanisms included: the formation of a gap (contact resistance) between the relocated and frozen debris and the vessel wall was a key aspect of the in-vessel cooling mechanism; wall heatup due to the relocated debris in the presence of wall stress due to a pressure gradient across the vessel wall; gap growth due to a lack of debris adherence to the vessel wall and material creep of the heated vessel wall; and the potential for enhanced wall cooling due to gap growth. Each of these postulated mechanisms was investigated in this experimental program. This report summarizes the several insights and conclusions that were obtained from this experimental program. This report documents the entire set of five experiments completed in Phase 2 of this experimental program. Results from the Phase 1 effort were used to plan and select the Phase 2 test matrix. Conclusions from the Phase 1 and 2 experiments are identified and recommendations for future work are provided

  11. Prestressed concrete vessels suitable for helium high temperature reactors

    International Nuclear Information System (INIS)

    Lockett, G.E.; Kinkead, A.N.

    1967-02-01

    In considering prestressed concrete vessels for use with helium cooled high temperature reactors, a number of new problems arise and projected designs involve new approaches and new solutions. These reactors, having high coolant outlet temperature from the core and relatively high power densities, can be built into compact designs which permit usefully high working pressures. Consequently, steam generators and circulating units tend to be small. Although circuit activity can be kept quite low with coated particle fuels, designs which involve entry for subsequent repair are not favoured, and coupled with the preferred aim of using fully shop fabricated units within the designs with removable steam generators which involve no tube welding inside the vessel. A particular solution uses a number of slim cylindrical assemblies housed in the wall of the pressure vessel and this vessel design concept is presented. The use of helium requires very high sealing standards and one of the important requirements is a vessel design which permits leak testing during construction, so that a repair seal can be made to any faulty part in a liner seam. Very good demountable joint seals can be made without particular difficulty and Dragon experience is used to provide solutions which are suitable for prestressed concrete vessel penetrations. The concept layout is given of a vessel meeting these requirements; the basis of design is outlined and special features of importance discussed. (author)

  12. Effects of different progestin regimens in hormone replacement therapy on blood coagulation factor VII and tissue factor pathway inhibitor

    DEFF Research Database (Denmark)

    Bladbjerg, E-M; Skouby, S O.; Andersen, L F

    2002-01-01

    BACKGROUND: Long-term hormone replacement therapy (HRT) reduces cardiovascular risk, but an early increased risk was reported in women with coronary heart disease. In such women the arterial intima can express tissue factor, and changes in coagulation factor VII (factor VII) and tissue factor...... pathway inhibitor (TFPI) may be deleterious. METHODS: We measured factor VII clotting activity, activated factor VII, and concentrations of factor VII and TFPI during 12 months in healthy post-menopausal women randomized to: (i). cyclic oral estrogen/progestin (n = 25); (ii). long-cycle oral estrogen......: No variations were observed in the reference group. There was a substantial decrease in TFPI concentrations in the HRT groups irrespective of the type of progestin. In women receiving long-cycle treatment, all factor VII measures increased during the unopposed estrogen periods, and the increase was reversed...

  13. BY FRUSTUM CONFINING VESSEL

    Directory of Open Access Journals (Sweden)

    Javad Khazaei

    2016-09-01

    Full Text Available Helical piles are environmentally friendly and economical deep foundations that, due to environmental considerations, are excellent additions to a variety of deep foundation alternatives available to the practitioner. Helical piles performance depends on soil properties, the pile geometry and soil-pile interaction. Helical piles can be a proper alternative in sensitive environmental sites if their bearing capacity is sufficient to support applied loads. The failure capacity of helical piles in this study was measured via an experimental research program that was carried out by Frustum Confining Vessel (FCV. FCV is a frustum chamber by approximately linear increase in vertical and lateral stresses along depth from top to bottom. Due to special geometry and applied bottom pressure, this apparatus is a proper choice to test small model piles which can simulate field stress conditions. Small scale helical piles are made with either single helix or more helixes and installed in fine grained sand with three various densities. Axial loading tests including compression and tension tests were performed to achieve pile ultimate capacity. The results indicate the helical piles behavior depends essentially on pile geometric characteristics, i.e. helix configuration and soil properties. According to the achievements, axial uplift capacity of helical model piles is about equal to usual steel model piles that have the helixes diameter. Helical pile compression bearing capacity is too sufficient to act as a medium pile, thus it can be substituted other piles in special geoenvironmental conditions. The bearing capacity also depends on spacing ratio, S/D, and helixes diameter.

  14. Vacuum vessel for thermonuclear device

    International Nuclear Information System (INIS)

    Hagiwara, Koji; Imura, Yasuya.

    1979-01-01

    Purpose: To provide constituted method for easily performing baking of vacuum vessel, using short-circuiting segments. Constitution: At the time of baking, one turn circuit is formed by the vacuum vessel and short-circuiting segments, and current transformer converting the one turn circuit into a secondary circuit by the primary coil and iron core is formed, and the vacuum vessel is Joule heated by an induction current from the primary coil. After completion of baking, the short-circuiting segments are removed. (Kamimura, M.)

  15. PWR vessel inspection performance improvements

    International Nuclear Information System (INIS)

    Blair Fairbrother, D.; Bodson, Francis

    1998-01-01

    A compact robot for ultrasonic inspection of reactor vessels has been developed that reduces setup logistics and schedule time for mandatory code inspections. Rather than installing a large structure to access the entire weld inspection area from its flange attachment, the compact robot examines welds in overlapping patches from a suction cup anchor to the shell wall. The compact robot size allows two robots to be operated in the vessel simultaneously. This significantly reduces the time required to complete the inspection. Experience to date indicates that time for vessel examinations can be reduced to fewer than four days. (author)

  16. Motor palsies of cranial nerves (excluding VII) after vaccination: reports to the US Vaccine Adverse Event Reporting System.

    Science.gov (United States)

    Woo, Emily Jane; Winiecki, Scott K; Ou, Alan C

    2014-01-01

    We reviewed cranial nerve palsies, other than VII, that have been reported to the US Vaccine Adverse Event Reporting System (VAERS). We examined patterns for differences in vaccine types, seriousness, age, and clinical characteristics. We identified 68 reports of cranial nerve palsies, most commonly involving the oculomotor (III), trochlear (IV), and abducens (VI) nerves. Isolated cranial nerve palsies, as well as palsies occurring as part of a broader clinical entity, were reported. Forty reports (59%) were classified as serious, suggesting that a cranial nerve palsy may sometimes be the harbinger of a broader and more ominous clinical entity, such as a stroke or encephalomyelitis. There was no conspicuous clustering of live vs. inactivated vaccines. The patient age range spanned the spectrum from infants to the elderly. Independent data may help to clarify whether, when, and to what extent the rates of cranial nerve palsies following particular vaccines may exceed background levels.

  17. Impurity transport in the Wendelstein VII-A stellarator

    International Nuclear Information System (INIS)

    1985-01-01

    Impurity radiation losses in net-current-free neutral-beam-heated plasmas in the Wendelstein W VII-A stellarator are the combined effect of particularly strong impurity sources and improved particle confinement as compared with ohmically heated tokamak-like plasma discharges. Experiments are described and conclusions are drawn about the impurity species, their origin and their transport behaviour. The impurity transport is modelled by a 1-D impurity transport and radiation code. The evolution of the total radiation in time and space deduced from soft-X-ray and bolometer measurements can be fairly well simulated by the code. Experimentally, oxygen was found to make the main contribution to the radiation losses. In the calculations, an influx of cold oxygen desorbed from the walls of the order of 10 13 -10 14 cm -2 .s -1 and a rate of fast injected oxygen corresponding to a 1% impurity content of the neutral beams in combination with neoclassical impurity transport leads to quantitative agreement between the simulation and the observed radiation. The transport of A1 trace impurities injected by the laser blow-off technique was experimentally studied by soft-X-ray measurements using a differential method allowing extraction of the time evolution of A1 XII, XIII radial profiles. These are compared with code predictions, together with additional spectroscopic measurements. The main features of the impurity transport are consistent with neoclassical predictions, which explain particularly the central impurity accumulation. Some details, however, seem to require additional 'anomalous' transport. Such an enhancement is correlated with distortions of the magnetic configuration around resonant magnetic surfaces. (author)

  18. Topical application of recombinant activated factor VII during cesarean delivery for placenta previa.

    Science.gov (United States)

    Schjoldager, Birgit T B G; Mikkelsen, Emmeli; Lykke, Malene R; Præst, Jørgen; Hvas, Anne-Mette; Heslet, Lars; Secher, Niels J; Salvig, Jannie D; Uldbjerg, Niels

    2017-06-01

    During cesarean delivery in patients with placenta previa, hemorrhaging after removal of the placenta is often challenging. In this condition, the extraordinarily high concentration of tissue factor at the placenta site may constitute a principle of treatment as it activates coagulation very effectively. The presumption, however, is that tissue factor is bound to activated factor VII. We hypothesized that topical application of recombinant activated factor VII at the placenta site reduces bleeding without affecting intravascular coagulation. We included 5 cases with planned cesarean delivery for placenta previa. After removal of the placenta, the surgeon applied a swab soaked in recombinant activated factor VII containing saline (1 mg in 246 mL) to the placenta site for 2 minutes; this treatment was repeated once if the bleeding did not decrease sufficiently. We documented the treatment on video recordings and measured blood loss. Furthermore, we determined hemoglobin concentration, platelet count, international normalized ratio, activated partial thrombin time, fibrinogen (functional), factor VII:clot, and thrombin generation in peripheral blood prior to and 15 minutes after removal of the placenta. We also tested these blood coagulation variables in 5 women with cesarean delivery planned for other reasons. Mann-Whitney test was used for unpaired data. In all 5 cases, the uterotomy was closed under practically dry conditions and the median blood loss was 490 (range 300-800) mL. There were no adverse effects of recombinant activated factor VII and we did not measure factor VII to enter the circulation. Neither did we observe changes in thrombin generation, fibrinogen, activated partial thrombin time, international normalized ratio, and platelet count in the peripheral circulation (all P values >.20). This study indicates that in patients with placenta previa, topical recombinant activated factor VII may diminish bleeding from the placenta site without initiation

  19. Concrete containment vessels (CCV) for nuclear power plants, (1)

    International Nuclear Information System (INIS)

    Ibe, Yukimi; Kitajima, Masatake

    1977-01-01

    Containment vessels (CV) and the construction of concrete containment vessels (CCV) for nuclear power plants are described generally, and their use and techniques in foreign countries are illustrated, in connection with the introduction of CCV to Japanese nuclear power plants. The introduction deals with the construction plan of Japanese nuclear power plants, and with the difficulties in the steel CV for large scale construction. The investigations, tests and researches are not yet sufficient. The prompt establishment of safety supported by technical criteria, analytical methods and experiments is desired. The second part deals with the consideration for aseismatic design, construction, function and characteristics of CCV. The classification and currently employed CCV, which is mainly reinforced concrete containment vessels (RCCV), are described, and the typical CCV employed for BWR is illustrated. Further, the typical arrangement of reinforcing steels at the cylindrical portion and the dome portion of RCCV is illustrated. The third part deals with the present state of CCV abroad. A prestressed concrete containment vessel (PCCV) of Turkey Point power plant is illustrated as a typical example of CCV. The tests reported in the international meeting for the design, construction and operation of concrete pressure vessels and concrete containment vessels at York University in England in 1975 are reviewed. Typical examples of the design conditions, the size and form, and the construction procedure for PCCV and RCCV abroad are reviewed. (Iwakiri, K.)

  20. Special enclosure for a pressure vessel

    International Nuclear Information System (INIS)

    Wedellsborg, B.W.; Wedellsborg, U.W.

    1993-01-01

    A pressure vessel enclosure is described comprising a primary pressure vessel, a first pressure vessel containment assembly adapted to enclose said primary pressure vessel and be spaced apart therefrom, a first upper pressure vessel jacket adapted to enclose the upper half of said first pressure vessel containment assembly and be spaced apart therefrom, said upper pressure vessel jacket having an upper rim and a lower rim, each of said rims connected in a slidable relationship to the outer surface of said first pressure vessel containment assembly, mean for connecting in a sealable relationship said upper rim of said first upper pressure vessel jacket to the outer surface of said first pressure vessel containment assembly, means for connecting in a sealable relationship said lower rim of said first upper pressure vessel jacket to the outer surface of said first pressure vessel containment assembly, a first lower pressure vessel jacket adapted to enclose the lower half of said first pressure vessel containment assembly and be spaced apart therefrom, said lower pressure vessel jacket having an upper rim connected in a slidable relationship to the outer surface of said first pressure vessel containment assembly, and means for connecting in a sealable relationship said upper rim of said first lower pressure vessel jacket to the outer surface of said first pressure vessel containment assembly, a second upper pressure vessel jacket adapted to enclose said first upper pressure vessel jacket and be spaced apart therefrom, said second upper pressure vessel jacket having an upper rim and a lower rim, each of said rims adapted to slidably engage the outer surface of said first upper pressure vessel jacket, means for sealing said rims, a second lower pressure vessel jacket adapted to enclose said first lower pressure vessel jacket and be spaced apart therefrom

  1. Contextos cerámicos de los siglos V-VII en Cartagena

    Directory of Open Access Journals (Sweden)

    Ramallo Asensio, Sebastián F.

    1996-12-01

    Full Text Available The excavations realized in the Roman theatre of Cartagena have documented a wide stratigraphie sequence with covers levels from IInd century B.C. to today. The material contexts of Vth to VIIth B.C. are specially interesting because they were associated with considerable removals of the town planning. The construction of a comercial site in the second half of the Vth century, markets and stores, built on a big exedra with portico and 15 divisions in line, represents the total use of the theatre, the structures of which became fossilized, in part, in a new shape. A village of Byzantin age was built over both constructions, characterized with quadrangular rooms which alternates with opened public spaces and irregular streets adjusted to the artificial and inclined topography dependent on the precedent constructions.Las excavaciones realizadas en el teatro romano de Cartagena han documentado una amplia secuencia estratigráfica que abarca desde niveles del siglo II a. de C. hasta nuestros días. Especialmente interesantes son los contextos materiales de los siglos V al VII, asociados a profundas remociones de carácter urbanístico. La construcción en la segunda mitad del siglo V de un complejo comercial, mercado/almacén, estructurado sobre una gran exedra porticada y una serie de 15 compartimentos alineados, representa la amortización total del edificio del teatro cuyas estructuras en parte fosiliza el nuevo conjunto. Encima de ambas construcciones se construyó un barrio de época bizantina caracterizado por habitaciones de forma cuadrangular que alternan con espacios comunes abiertos y calles de trazado irregular adaptadas a la topografía artificial y en pendiente impuesta por las construcciones precedentes.

  2. Certifying the decommissioned Shippingport reactor vessel for transport

    International Nuclear Information System (INIS)

    Towell, R.H.

    1990-01-01

    The decommissioned Shippingport reactor pressure vessel with its concentric neutron shield tank was shipped to Hanford, WA as part of the effort to restore the Shippingport Station to its original condition. The metal walls of the reactor vessel had become radioactive from neutron bombardment while the reactor was operating so it had to be shipped under the regulations for transporting radioactive material. Because of the large amount of radioactivity in the walls, 16,467 Curies, and because the potentially dispersible corrosion layer on the inner walls of both tanks was also radioactive, the Shippingport reactor vessel was transported under the most stringent of the regulations, those for a type B package. Compliance with the packaging regulations was confirmed via independent analysis by the staff of the Department of Energy certifying official and the Shippingport reactor vessel was shipped under DOE Certificate of Compliance USA/9515/B(U)

  3. NET in-vessel vehicle system

    International Nuclear Information System (INIS)

    Jones, H.

    1991-02-01

    The CFFTP/Spar In-vessel Vehicle System concept for in-vessel remote maintenance of the NET/ITER machine is described. It comprises a curved deployable boom, a vehicle which can travel on the boom and an end effector or work unit mounted on the vehicle. The stowed boom, vehicle, and work unit are inserted via the equatorial access port of the torus. Following insertion the boom is deployed and locked in place. The vehicle may then travel along the boom to transport the work unit to any desired location. A novel feature of the concept is the deployable boom. When fully deployed, it closely resembles a conventional curved truss structure in configuration and characteristics. However, the joints of the truss structure are hinged so that it can fold into a compact package, of less than 20% of deployed volume for storage, transportation and insertion into the torus. A full-scale 2-metre long section of this boom was produced for demonstration purposes. As part of the concept definition the work unit for divertor handling was studied to demonstrate that large payloads could be manipulated within the confines of the torus using the in-vessel vehicle system. Principal advantages of the IVVS are its high load capacity and rigidity, low weight and stowed volume, simplicity of control and operation, and its relatively high speed of transportation

  4. Evaluation of In-Vessel Corium Retention under a Severe Accident

    Energy Technology Data Exchange (ETDEWEB)

    Park, Rae-Joon; Kang, Kyung-Ho; Ha, Kwang-Soon; Kim, Jong-Tae; Koo, Kil-Mo; Cho, Young-Ro; Hong, Seong-Wan; Kim, Sang-Baik; Kim, Hee-Dong

    2008-02-15

    The current study on In-Vessel corium Retention and its application activities to the actual nuclear power plant have been reviewed and discussed in this study. Severe accident sequence which determines an initial condition of the IVR has been evaluated and late phase melt progression, heat transfer on the outer reactor vessel, and in-vessel corium cooling mechanism have been estimated in detail. During the high pressure sequence of the reactor coolant system, a natural circulation flow of the hot steam leads to a failure of the pressurizer surge line before the reactor vessel failure, which leads to a rapid decrease of the reactor coolant system pressure. The results of RASPLAV/MASCA study by OECD/NEA have shown that a melt stratification has occurred in the lower plenum of the reactor vessel. In particular, laver inversion has occurred, which is that a high density of the metal melt moves to the lower part of the oxidic melt layer. A method of heat transfer enhancement on the outer reactor vessel is an optimal design of the reactor vessel insulation for an increase of the natural circulation flow between the outer reactor vessel and the its insulation, and an increase of the critical Heat flux on the outer reactor vessel by using various method, such as Nono fluid, coated reactor vessel, and so on. An increase method of the in-vessel melt cooling is a development of the In-vessel core catcher and a decrease of focusing effect in the metal layer.

  5. Factor VII deficiency: a novel missense variant and genotype-phenotype correlation in patients from Southern Italy.

    Science.gov (United States)

    Tiscia, Giovanni; Favuzzi, Giovanni; Chinni, Elena; Colaizzo, Donatella; Fischetti, Lucia; Intrieri, Mariano; Margaglione, Maurizio; Grandone, Elvira

    2017-01-01

    This study aimed at attempting to correlate genotype and phenotype in factor VII deficiency. Here, we present molecular and clinical findings of 10 patients with factor VII deficiency. From 2013 to 2016, 10 subjects were referred to our center because of a prolonged prothrombin time identified during routine or presurgery examinations or after a laboratory assessment of a bleeding episode. Mutation characterization was performed using the bioinformatics applications PROMO, SIFT, and Polyphen-2. Structural changes in the factor VII protein were analyzed using the SPDB viewer tool. Of the 10 variants we identified, 1 was responsible for a novel missense change (c.1199G>C, p.Cys400Ser); in 2 cases we identified the c.-54G>A and c.509G>A (p.Arg170His) polymorphic variants in the 5'-upstream region of the factor VII gene and exon 6, respectively. To our knowledge, neither of these polymorphic variants has been described previously in factor VII-deficient patients. In silico predictions showed differences in binding sites for transcription factors caused by the c.-54G>A variant and a probable damaging effect of the p.Cys400Ser missense change on factor VII active conformation, leading to breaking of the Cys400-Cys428 disulfide bridge. Our findings further suggest that, independently of factor VII levels and of variants potentially affecting factor VII levels, environmental factors, e.g., trauma, could heavily influence the clinical phenotype of factor VII-deficient patients.

  6. Prophylaxis in congenital factor VII deficiency: indications, efficacy and safety. Results from the Seven Treatment Evaluation Registry (STER).

    Science.gov (United States)

    Napolitano, Mariasanta; Giansily-Blaizot, Muriel; Dolce, Alberto; Schved, Jean F; Auerswald, Guenter; Ingerslev, Jørgen; Bjerre, Jens; Altisent, Carmen; Charoenkwan, Pimlak; Michaels, Lisa; Chuansumrit, Ampaiwan; Di Minno, Giovanni; Caliskan, Umran; Mariani, Guglielmo

    2013-04-01

    Because of the very short half-life of factor VII, prophylaxis in factor VII deficiency is considered a difficult endeavor. The clinical efficacy and safety of prophylactic regimens, and indications for their use, were evaluated in factor VII-deficient patients in the Seven Treatment Evaluation Registry. Prophylaxis data (38 courses) were analyzed from 34 patients with severe factor VII deficiency (factor VII (24 courses), four received plasma-derived factor VII, and ten received fresh frozen plasma. Prophylactic schedules clustered into "frequent" courses (three times weekly, n=23) and "infrequent" courses (≤ 2 times weekly, n=15). Excluding courses for menorrhagia, "frequent" and "infrequent" courses produced 18/23 (78%) and 5/12 (41%) "excellent" outcomes, respectively; relative risk, 1.88; 95% confidence interval, 0.93-3.79; P=0.079. Long term prophylaxis lasted from 1 to >10 years. No thrombosis or new inhibitors occurred. In conclusion, a subset of patients with factor VII deficiency needed prophylaxis because of severe bleeding. Recombinant activated factor VII schedules based on "frequent" administrations (three times weekly) and a 90 μg/kg total weekly dose were effective. These data provide a rationale for long-term, safe prophylaxis in factor VII deficiency.

  7. 2013 West Coast Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  8. 2011 West Coast Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  9. 2013 Great Lakes Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  10. 2011 Great Lakes Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  11. 2011 East Coast Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  12. Coastal Discard Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains data on the type and amount of marine resources that are discarded or interacted with by vessels that are selected to report to the Southeast...

  13. SC/OQ Vessel Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data tables holding information for the Surf Clam/Ocean Quahog vessel and dealer/processor logbooks (negative and positive), as well as individual tag information...

  14. Vessel Permit System Data Set

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — GARFO issues federal fishing permits annually to owners of fishing vessels who fish in the Greater Atlantic region, as required by federal regulation. These permits...

  15. Reactor pressure vessel status report

    International Nuclear Information System (INIS)

    Strosnider, J.; Wichman, K.; Elliot, B.

    1994-12-01

    This report gives a brief description of the reactor pressure vessel (RPV), followed by a discussion of the radiation embrittlement of RPV beltline materials and the two indicators for measuring embrittlement, the end-of-license (EOL) reference temperature and the EOL upper-shelf energy. It also summarizes the GL 92-01 effort and presents, for all 37 boiling water reactor plants and 74 pressurized water reactor plants in the United States, the current status of compliance with regulatory requirements related to ensuring RPV integrity. The staff has evaluated the material data needed to predict neutron embrittlement of the reactor vessel beltline materials. These data will be stored in a computer database entitled the reactor vessel integrity database (RVID). This database will be updated annually to reflect the changes made by the licensees in future submittals and will be used by the NRC staff to assess the issues related to vessel structural integrity

  16. Reactor-vessel-sectioning demonstration

    International Nuclear Information System (INIS)

    Lundgren, R.A.

    1981-07-01

    A successful technical demonstration of simulated reactor vessel sectioning was completed using the combined techniques of air arc gouging and flame cutting. A 4-ft x 3-ft x 9-in. thick sample was fabricated of A36 carbon steel to simulate a reactor vessel wall. A 1/4-in layer of stainless steel (SS) was tungsten inert gas (TIG)-welded to the carbon steel. Several techniques were considered to section the simulated reactor vessel: an air arc gouger was chosen to penetrate the stainless steel, and flame cutting was selected to sever the carbon steel. After the simulated vessel was successfully cut from the SS side, another cut was made, starting from the carbon steel side. This cut was also successful. Cutting from the carbon steel side has the advantages of cost reduction since the air arc gouging step is eliminated and contamination controlled because the molten metal is blown inward

  17. Modeling the Thermal Mechanical Behavior of a 300 K Vacuum Vessel that is Cooled by Liquid Hydrogen in Film Boiling

    International Nuclear Information System (INIS)

    Yang, S.Q.; Green, M.A.; Lau, W.

    2004-01-01

    This report discusses the results from the rupture of a thin window that is part of a 20-liter liquid hydrogen vessel. This rupture will spill liquid hydrogen onto the walls and bottom of a 300 K cylindrical vacuum vessel. The spilled hydrogen goes into film boiling, which removes the thermal energy from the vacuum vessel wall. This report analyzes the transient heat transfer in the vessel and calculates the thermal deflection and stress that will result from the boiling liquid in contact with the vessel walls. This analysis was applied to aluminum and stainless steel vessels

  18. Power reactor pressure vessel benchmarks

    International Nuclear Information System (INIS)

    Rahn, F.J.

    1978-01-01

    A review is given of the current status of experimental and calculational benchmarks for use in understanding the radiation embrittlement effects in the pressure vessels of operating light water power reactors. The requirements of such benchmarks for application to pressure vessel dosimetry are stated. Recent developments in active and passive neutron detectors sensitive in the ranges of importance to embrittlement studies are summarized and recommendations for improvements in the benchmark are made. (author)

  19. PWR reactor pressure vessel failure probabilities

    International Nuclear Information System (INIS)

    Dufresne, J.; Lanore, J.M.; Lucia, A.C.; Elbaz, J.; Brunnhuber, R.

    1980-05-01

    To evaluate the rupture probability of a LWR vessel a probabilistic method using the fracture mechanics under probabilistic form has been proposed previously, but it appears that more accurate evaluation is possible. In consequence a joint collaboration agreement signed in 1976 between CEA, EURATOM, JRC Ispra and FRAMATOME set up and started a research program covering three parts: a computer code development, data acquisition and processing, and a support experimental program which aims at clarifying the most important parameters used in the COVASTOL computer code

  20. 78 FR 40265 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel HMS-DISCOVERY; Invitation for...

    Science.gov (United States)

    2013-07-03

    ... Administrative Waiver of the Coastwise Trade Laws: Vessel HMS-DISCOVERY; Invitation for Public Comments AGENCY... of the vessel HMS-DISCOVERY is: Intended Commercial Use of Vessel: ``Sight Seeing Tours''. Geographic... regulations at 46 CFR Part 388. Privacy Act Anyone is able to search the electronic form of all comments...

  1. Prosopomorphic vessels from Moesia Superior

    Directory of Open Access Journals (Sweden)

    Nikolić Snežana

    2008-01-01

    Full Text Available The prosopomorphic vessels from Moesia Superior had the form of beakers varying in outline but similar in size. They were wheel-thrown, mould-made or manufactured by using a combination of wheel-throwing and mould-made appliqués. Given that face vessels are considerably scarcer than other kinds of pottery, more than fifty finds from Moesia Superior make an enviable collection. In this and other provinces face vessels have been recovered from military camps, civilian settlements and necropolises, which suggests that they served more than one purpose. It is generally accepted that the faces-masks gave a protective role to the vessels, be it to protect the deceased or the family, their house and possessions. More than forty of all known finds from Moesia Superior come from Viminacium, a half of that number from necropolises. Although tangible evidence is lacking, there must have been several local workshops producing face vessels. The number and technological characteristics of the discovered vessels suggest that one of the workshops is likely to have been at Viminacium, an important pottery-making centre in the second and third centuries.

  2. Vacuum vessel for thermonuclear device

    International Nuclear Information System (INIS)

    Kikuchi, Mitsuru; Kurita, Gen-ichi; Onozuka, Masaki; Suzuki, Masaru.

    1997-01-01

    Heat of inner walls of a vacuum vessel that receive radiation heat from plasmas by way of first walls is removed by a cooling medium flowing in channels for cooling the inner walls. Nuclear heat generation of constitutional materials of the vacuum vessel caused by fast neutrons and γ rays is removed by a cooling medium flowing in cooling channels disposed in the vacuum vessel. Since the heat from plasmas and the nuclear heat generation are removed separately, the amount of the cooling medium flowing in the channels for cooling inner walls is increased for cooling a great amount of heat from plasmas while the amount of the cooling medium flowing in the channels for cooling the inside of the vacuum vessel is reduced for cooling the small amount of nuclear heat generation. Since the amount of the cooling medium can thus be optimized, the capacity of the facilities for circulating the cooling medium can be reduced. In addition, since the channels for cooling the inner walls and the channels of cooling medium formed in the vacuum vessel are disposed to the inner walls of the vacuum vessel on the side opposite to plasmas, integrity of the channels relative to leakage of the cooling medium can be ensured. (N.H.)

  3. Vacuum vessel for thermonuclear device

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, Mitsuru; Kurita, Gen-ichi [Japan Atomic Energy Research Inst., Tokyo (Japan); Onozuka, Masaki; Suzuki, Masaru

    1997-07-31

    Heat of inner walls of a vacuum vessel that receive radiation heat from plasmas by way of first walls is removed by a cooling medium flowing in channels for cooling the inner walls. Nuclear heat generation of constitutional materials of the vacuum vessel caused by fast neutrons and {gamma} rays is removed by a cooling medium flowing in cooling channels disposed in the vacuum vessel. Since the heat from plasmas and the nuclear heat generation are removed separately, the amount of the cooling medium flowing in the channels for cooling inner walls is increased for cooling a great amount of heat from plasmas while the amount of the cooling medium flowing in the channels for cooling the inside of the vacuum vessel is reduced for cooling the small amount of nuclear heat generation. Since the amount of the cooling medium can thus be optimized, the capacity of the facilities for circulating the cooling medium can be reduced. In addition, since the channels for cooling the inner walls and the channels of cooling medium formed in the vacuum vessel are disposed to the inner walls of the vacuum vessel on the side opposite to plasmas, integrity of the channels relative to leakage of the cooling medium can be ensured. (N.H.)

  4. Studies on normal-conducting coils for Wendelstein VII-X

    International Nuclear Information System (INIS)

    Harmeyer, E.; Kisslinger, J.; Rau, F.; Sapper, J.; Wobig, H.

    1990-08-01

    For Wendelstein VII-X, the next step stellarator experiment at IPP Garching, a Helias configuration has been chosen. The goals of Wendelstein VII-X are to continue the development of the modular stellarator and to demonstrate the reactor capability of this stellarator line. The main data of the selected HS5-10 configuration with five field periods are: major radius R 0 = 5.5 m, magnetic induction B 0 = 3 T and stored magnetic energy W ≅ 0.6 GJ. For comparison with the superconducting coil system which is foreseen for Wendelstein VII-X, a pulsed water-cooled normal-conducting version has been designed in order to explore the limitations and restrictions of this approach. Limitations are the high ohmic power dissipated in the coils and the electric energy currently available at IPP. Normal-conducting coils would allow to apply the well-known techniques in manufactoring these coils, as successful in use in the Wendelstein VII-AS experiment. But these techniques are applicable also for the conductor proposed for the superconducting coils of Wendelstein VII-X. In this report the time-dependent current and resistance of the coil system circuit is considered; the electric power needed, the total dissipated energy, and the temperature rise of the coil copper is calculated. Scaling laws are derived and parameter studies are made by varying the geometrical dimensions of the system. (orig.)

  5. Mendeleev-2013. VII All-Russian conference of young scientists, postgraduate students and students with international participation on chemistry and nanomaterials. Book of abstracts. Section 4. Organic chemistry

    International Nuclear Information System (INIS)

    2013-01-01

    VII All-Russian conference of young scientists, postgraduate students and students with international participation on chemistry and nanomaterials was conducted on the Chemistry department of Saint-Petersburg University on April, 2-5, 2013. In the conference participants from 14 countries took part. There were five sections: Nanochemistry and nanomaterials, Analytic chemistry, Inorganic chemistry, Organic chemistry, Physical chemistry. In the collection (Section 2 - Organic chemistry) there are the abstracts concerning different aspects of organic chemistry: synthesis and study of properties of heterocyclic, organometallic, biologically active, medicinal compounds, new ion exchange materials, reagents for analytic chemistry, etc [ru

  6. Mendeleev-2013. VII All-Russian conference of young scientists, postgraduate students and students with international participation on chemistry and nanomaterials. Book of abstracts. Section 2. Analytic chemistry

    International Nuclear Information System (INIS)

    2013-01-01

    VII All-Russian conference of young scientists, postgraduate students and students with international participation on chemistry and nanomaterials was conducted on the Chemistry department of Saint-Petersburg University on April, 2-5, 2013. In the conference participants from 14 countries took part. There were five sections: Nanochemistry and nanomaterials, Analytic chemistry, Inorganic chemistry, Organic chemistry, Physical chemistry. In the collection (Section 2 - Analytic chemistry) there are the abstracts concerning determination of heavy metals in environmental samples, petroleum products, different biological active and toxic substances in human tissues, food products and water; usage of nanoparticles for modification of electrodes for electrochemical methods of analysis, etc [ru

  7. Automated method for identification and artery-venous classification of vessel trees in retinal vessel networks.

    Science.gov (United States)

    Joshi, Vinayak S; Reinhardt, Joseph M; Garvin, Mona K; Abramoff, Michael D

    2014-01-01

    The separation of the retinal vessel network into distinct arterial and venous vessel trees is of high interest. We propose an automated method for identification and separation of retinal vessel trees in a retinal color image by converting a vessel segmentation image into a vessel segment map and identifying the individual vessel trees by graph search. Orientation, width, and intensity of each vessel segment are utilized to find the optimal graph of vessel segments. The separated vessel trees are labeled as primary vessel or branches. We utilize the separated vessel trees for arterial-venous (AV) classification, based on the color properties of the vessels in each tree graph. We applied our approach to a dataset of 50 fundus images from 50 subjects. The proposed method resulted in an accuracy of 91.44% correctly classified vessel pixels as either artery or vein. The accuracy of correctly classified major vessel segments was 96.42%.

  8. Paraho environmental data. Part IV. Land reclamation and revegetation. Part V. Biological effects. Part VI. Occupational health and safety. Part VII. End use

    Energy Technology Data Exchange (ETDEWEB)

    Limbach, L.K.

    1982-06-01

    Characteristics of the environment and ecosystems at Anvil Points, reclamation of retorted shale, revegetation of retorted shale, and ecological effects of retorted shale are reported in the first section of this report. Methods used in screening shale oil and retort water for mutagens and carcinogens as well as toxicity studies are reported in the second section of this report. The third section contains information concerning the industrial hygiene and medical studies made at Anvil Points during Paraho research operations. The last section discusses the end uses of shale crude oil and possible health effects associated with end use. (DMC)

  9. Vessel supporting structure for liquid metal cooled nuclear reactors

    International Nuclear Information System (INIS)

    Mahe, Armel; Jullien, Georges

    1974-01-01

    The supporting structure described is for a liquid metal cooled nuclear reactor, the vessel being of the type suspended to the end slab of the reactor. It includes a ring connected at one of its two ends to a single shell and at the other end to two shells. One of these three shells connected to the lower end of the ring forms the upper part of the vessel to be supported. The two other shells are embedded in two sperate parts of the slab. The ring and shell assembly is housed in an annular space provided in the end slab and separating it into two parts, namely a central part and a peripheral part [fr

  10. Ice-VII inclusions in diamonds: Evidence for aqueous fluid in Earth’s deep mantle

    Science.gov (United States)

    Tschauner, O.; Huang, S.; Greenberg, E.; Prakapenka, V. B.; Ma, C.; Rossman, G. R.; Shen, A. H.; Zhang, D.; Newville, M.; Lanzirotti, A.; Tait, K.

    2018-03-01

    Water-rich regions in Earth’s deeper mantle are suspected to play a key role in the global water budget and the mobility of heat-generating elements. We show that ice-VII occurs as inclusions in natural diamond and serves as an indicator for such water-rich regions. Ice-VII, the residue of aqueous fluid present during growth of diamond, crystallizes upon ascent of the host diamonds but remains at pressures as high as 24 gigapascals; it is now recognized as a mineral by the International Mineralogical Association. In particular, ice-VII in diamonds points toward fluid-rich locations in the upper transition zone and around the 660-kilometer boundary.

  11. Verification and validation of ACE-format library created from ENDF/B-VII.0

    International Nuclear Information System (INIS)

    Chen Chaobin; Hu Zehua; Zhang Benai; Chen Yixue; Wu Jun

    2009-01-01

    ENDF/B-VII.0, released by the USA Cross Section Evaluation Working Group(CSEWG) in December 2006, was developed in five years since the previous release of ENDF/B-VI.8 and was demonstrated to contain much better physical representations of the data and to perform much better than previus ENDF evaluations over a broad range of applications. We generated ACE-format pointwise cross section library from the ENDF/B-VII.0 neutron reaction sublibrary with the processing code NJOY. The paper provides an overview of ENDF/B-VII.0, a summary of the ACE-format files producing process and a detail description of the validation of the ACE-format library. The conclusion is that the ACE-format library produced is correct. (authors)

  12. The TPX vacuum vessel and in-vessel components

    International Nuclear Information System (INIS)

    Heitzenroeder, P.; Bialek, J.; Ellis, R.; Kessel, C.; Liew, S.

    1994-01-01

    The Tokamak Physics Experiment (TPX) is a superconducting tokamak with double-null diverters. TPX is designed for 1,000-second discharges with the capability of being upgraded to steady state operation. High neutron yields resulting from the long duration discharges require that special consideration be given to materials and maintainability. A unique feature of the TPX is the use of a low activation, titanium alloy vacuum vessel. Double-wall vessel construction is used since it offers an efficient solution for shielding, bakeout and cooling. Contained within the vacuum vessel are the passive coil system, Plasma Facing Components (PFCs), magnetic diagnostics, and the internal control coils. All PFCs utilize carbon-carbon composites for exposed surfaces

  13. French administrative practice and design codes for nuclear vessels

    International Nuclear Information System (INIS)

    Roche, R.L.

    1987-07-01

    French regulations on boilers and pressure vessels have prevailed for a very long time, the first measure having been promulgated on 29 October 1823. Restraining the attention to nuclear pressure vessels it must be pointed out regulations and enforcement by public authorities are more stringent than they are for conventional pressure vessels. The first part of this paper will be devoted to regulations with a special attention to the decree of 26 February 1974 and to the practice of public authorities in this field with special attention given to the Bureau de Controle de la Construction Nucleaire (BCCN = Bureau of Inspection of Nuclear Design and Manufacturing). The second part of this paper will deal with the French construction codes for nuclear components RCC-M (water reactors) and RCC-MR (elevated temperature design)

  14. Clay Corner: Recreating Chinese Bronze Vessels.

    Science.gov (United States)

    Gamble, Harriet

    1998-01-01

    Presents a lesson where students make faux Chinese bronze vessels through slab or coil clay construction after they learn about the history, function, and design of these vessels. Utilizes a variety of glaze finishes in order to give the vessels an aged look. Gives detailed guidelines for creating the vessels. (CMK)

  15. Test facility for fast gas injections into a vessel filled with water

    International Nuclear Information System (INIS)

    Wilhelm, D.; Kirstahler, M.

    1987-11-01

    The Fast Gas Injection Facility (SGI) was set up to study the hydrodynamics during the expansion of a gas bubble into a vessel filled with water. The gas stored in a pressure vessel expands against gravity through a circular duct into a large cylindrical vessel partly with water. This report covers the description of the test facility and the data acquisition. Results of the first test series are added. (orig.) [de

  16. Coagulation factor VII is regulated by androgen receptor in breast cancer.

    Science.gov (United States)

    Naderi, Ali

    2015-02-01

    Androgen receptor (AR) is widely expressed in breast cancer; however, there is limited information on the key molecular functions and gene targets of AR in this disease. In this study, gene expression data from a cohort of 52 breast cancer cell lines was analyzed to identify a network of AR co-expressed genes. A total of 300 genes, which were significantly enriched for cell cycle and metabolic functions, showed absolute correlation coefficients (|CC|) of more than 0.5 with AR expression across the dataset. In this network, a subset of 35 "AR-signature" genes were highly co-expressed with AR (|CC|>0.6) that included transcriptional regulators PATZ1, NFATC4, and SPDEF. Furthermore, gene encoding coagulation factor VII (F7) demonstrated the closest expression pattern with AR (CC=0.716) in the dataset and factor VII protein expression was significantly associated to that of AR in a cohort of 209 breast tumors. Moreover, functional studies demonstrated that AR activation results in the induction of factor VII expression at both transcript and protein levels and AR directly binds to a proximal region of F7 promoter in breast cancer cells. Importantly, AR activation in breast cancer cells induced endogenous factor VII activity to convert factor X to Xa in conjunction with tissue factor. In summary, F7 is a novel AR target gene and AR activation regulates the ectopic expression and activity of factor VII in breast cancer cells. These findings have functional implications in the pathobiology of thromboembolic events and regulation of factor VII/tissue factor signaling in breast cancer. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. Vacuum vessel for thermonuclear device

    International Nuclear Information System (INIS)

    Kikuchi, Mitsuru; Nagashima, Keisuke; Suzuki, Masaru; Onozuka, Masaki.

    1997-01-01

    A vacuum vessel main body and structural members at the inside and the outside of the vacuum vessel main body are constituted by structural materials activated by irradiation of neutrons from plasmas such as stainless steels. Shielding members comprising tungsten or molybdenum are disposed on the surface of the vacuum vessel main body and the structural members of the inside and the outside of the main body. The shielding members have a function also as first walls or a seat member for the first walls. Armor tiles may be disposed to the shielding members. The shielding members and the armor tiles are secured to a securing seat member disposed, for example, to an inner plate of the vacuum vessel main body by bolts. Since the shielding members are disposed, it is not necessary to constitute the vacuum vessel main body and the structural members at the inside and the outside thereof by using a low activation material which is less activated, such as a titanium alloy. (I.N.)

  18. Vacuum vessel for thermonuclear device

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, Mitsuru; Nagashima, Keisuke [Japan Atomic Energy Research Inst., Tokyo (Japan); Suzuki, Masaru; Onozuka, Masaki

    1997-07-11

    A vacuum vessel main body and structural members at the inside and the outside of the vacuum vessel main body are constituted by structural materials activated by irradiation of neutrons from plasmas such as stainless steels. Shielding members comprising tungsten or molybdenum are disposed on the surface of the vacuum vessel main body and the structural members of the inside and the outside of the main body. The shielding members have a function also as first walls or a seat member for the first walls. Armor tiles may be disposed to the shielding members. The shielding members and the armor tiles are secured to a securing seat member disposed, for example, to an inner plate of the vacuum vessel main body by bolts. Since the shielding members are disposed, it is not necessary to constitute the vacuum vessel main body and the structural members at the inside and the outside thereof by using a low activation material which is less activated, such as a titanium alloy. (I.N.)

  19. Molten material-containing vessel

    International Nuclear Information System (INIS)

    Akagawa, Katsuhiko

    1998-01-01

    The molten material-containing vessel of the present invention comprises a vessel main body having an entrance opened at the upper end, a lid for closing the entrance, an outer tube having an upper end disposed at the lower surface of the lid, extended downwardly and having an closed lower end and an inner tube disposed coaxially with the outer tube. When a molten material is charged from the entrance to the inside of the vessel main body of the molten material-containing vessel and the entrance is closed by the lid, the outer tube and the inner tube are buried in the molten material in the vessel main body, accordingly, a fluid having its temperature elevated by absorption of the heat of the molten material rises along the inner circumferential surface of the outer tube, abuts against the lower surface of the lid and cooled by exchanging heat with the lid and forms a circulating flow. Since the heat in the molten material is continuously absorbed by the fluid, transferred to the lid and released from the lid to the atmospheric air, heat releasing efficiency can be improved compared with conventional cases. (N.H.)

  20. Vacuum vessels for the LHC magnets arrive at CERN

    CERN Multimedia

    2001-01-01

    The first batch of pre-series vacuum vessels for the LHC dipole magnets has just been delivered to CERN. The vessels are components of the cryostats and will provide the thermal insulation for the superconducting magnets. The first batch of vacuum vessels for the LHC dipole magnets with the team taking part at CERN in ordering and installing them. Left to right : Claude Hauviller, Monique Dupont, Lloyd Williams, Franck Gavin, Alain Jacob, Christophe Vuitton, Davide Bozzini, Laure Sandri, Mikael Sjoholm and André de Saever. In 2006 all that will be seen of the LHC superconducting dipoles in the LHC tunnel will be a line of over 1230 blue cylindrical vacuum vessels. Ten vessels, each weighing 4 tonnes, are already at CERN. On 6 July the first batch of pre-series vessels reached the Lab-oratory from the firm SIMIC Spa whose works are near Savona in north-western Italy. Despite appearances, these 15-metre long, 1-metre diameter blue tubes are much more sophisticated than sections of a run-of-the-mill...

  1. Stress analysis in a non axisymmetric loaded reactor pressure vessel

    International Nuclear Information System (INIS)

    Albuquerque, Levi Barcelos; Assis, Gracia Menezes V. de; Miranda, Carlos Alexandre J.; Cruz, Julio Ricardo B.; Mattar Neto, Miguel

    1995-01-01

    In this work we intend to present the stress analysis of a PWR vessel under postulated concentrated loads. The vessel was modeled with Axisymmetric solid 4 nodes harmonic finite elements with the use of the ANSYS program, version 5.0. The bolts connecting the vessel flanges were modeled with beam elements. Some considerations were made to model the contact between the flanges. The perforated part of the vessel tori spherical head was modeled (with reduced properties due to its holes) to introduce its stiffness and loads but was not within the scope of this work. The loading consists of some usual ones, as pressure, dead weight, bolts preload, seismic load and some postulated ones as concentrated loads, over the vessel, modeled by Fourier Series. The results in the axisymmetric model are taken in terms of linearized stresses, obtained in some circumferential positions and for each position, in some sections along the vessel. Using the ASME Code (Section III, Division 1, Sub-section NB) the stresses are within the allowable limits. In order to draw some conclusions about stress linearization, the membrane plus bending stresses (Pl + Pb) are obtained and compared in some sections, using three different methods. (author)

  2. In-vessel remote maintenance of the Compact Ignition Tokamak

    International Nuclear Information System (INIS)

    Tabor, M.A.; Hager, E.R.; Creedon, R.L.; Fisher, M.V.; Atkin, S.D.

    1987-01-01

    The Compact Ignition Tokamak (CIT) is the first deuterium-tritium (D-T) fusion device that will study the physics of an ignited plasma. The ability of the tokamak vacuum vessel to be maintained remotely while under vacuum has not been fully demonstrated on previous machines, and this ability will be critical to the efficient and safe operation of ignition devices. Although manned entry into the CIT vacuum vessel will be possible during the nonactivated stages of operation, remotely automated equipment will be used to assist in initial assembly of the vessel as well as to maintain all in-vessel components once the D-T burn is achieved. Remote maintenance and operation will be routinely required for replacement of thermal protection tiles, inspection of components, leak detection, and repair welding activities. Conceptual design to support these remote maintenance activities has been integrated with the conceptual design of the in-vessel components to provide a complete and practical remote maintenance system for CIT. The primary remote assembly and maintenance operations on CIT will be accomplished through two dedicated 37- x 100-cm ports on the main toroidal vessel. Each port contains a single articulated boom manipulator (ABM), which is capable of accessing half of the torus. The proposed ABM consists of a movable carriage assembly, telescoping two-part mast, and articulated link sections. 1 ref

  3. Total system for manufacture of nuclear vessels by computer: VECTRON

    International Nuclear Information System (INIS)

    Inagawa, Jin; Ueno, Osamu; Hanai, Yoshiharu; Ohkawa, Isao; Washizu, Hideyuki

    1980-01-01

    VECTRON (Vessel Engineering by Computer Tool and Rapid Operating for the N/C System) is a CAM (Computer Aided Manufacturing) system that has been developed to produce high quality and highly accurate vessels for nuclear power plants and other industrial plants. Outputs of this system are design drawings, manufacturing information and magnetic tapes of the N/C marking machine for vessel shell plates including their attachments. And it can also output information at each stage of designing, marking, cutting, forming and assembling by treating the vessels in three dimensions and by using data filing systems and plotting program for general use. The data filing systems consist of functional and manufacturing data of each part of vessels. This system not only realizes a change from manual work to computer work, but also leads us to improve production engineering and production jigs for safety and high quality. At present, VECTRON is being applied to the manufacture of the shell plates of primary containment vessels in the Kashiwazaki-Kariwa Nuclear Power Station Unit 1 (K-1) and the Fukushima Daini Nuclear Power Station Unit 3 (2F-3), to realize increased productivity. (author)

  4. Safety of steel vessel Magnox pressure circuits

    International Nuclear Information System (INIS)

    Stokoe, T.Y.; Bolton, C.J.; Heffer, P.J.H.

    1991-01-01

    The maintenance of pressure circuit integrity is fundamental to nuclear safety at the steel vessel Magnox stations. To confirm continued pressure circuit integrity the CEGB, as part of the Long Term Safety Review, has carried out extensive assessment and inspection in recent years. The assessment methods and inspection techniques employed are based on the most modern available. Reactor pressure vessel integrity is confirmed by a combination of arguments including safety factors inferred from the successful pre-service overpressure test, leak-before-break analysis and probabilistic assessment. In the case of other parts of the pressure circuits that are more accessible, comprising the boiler shells and interconnecting gas duct work, in-service inspection is a major element of the safety substantiation. The assessment and inspection techniques and the materials property data have been underpinned for many years by extensive research and development programmes and in-reactor monitoring of representative samples has also been undertaken. The paper summarises the work carried out to demonstrate the long term integrity of the Magnox pressure circuits and provides examples of the results obtained. (author)

  5. Development and plasticity of meningeal lymphatic vessels.

    Science.gov (United States)

    Antila, Salli; Karaman, Sinem; Nurmi, Harri; Airavaara, Mikko; Voutilainen, Merja H; Mathivet, Thomas; Chilov, Dmitri; Li, Zhilin; Koppinen, Tapani; Park, Jun-Hee; Fang, Shentong; Aspelund, Aleksanteri; Saarma, Mart; Eichmann, Anne; Thomas, Jean-Léon; Alitalo, Kari

    2017-12-04

    The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known about their development or maintenance. We show here that meningeal LVs develop postnatally, appearing first around the foramina in the basal parts of the skull and spinal canal, sprouting along the blood vessels and cranial and spinal nerves to various parts of the meninges surrounding the central nervous system (CNS). VEGF-C, expressed mainly in vascular smooth muscle cells, and VEGFR3 in lymphatic endothelial cells were essential for their development, whereas VEGF-D deletion had no effect. Surprisingly, in adult mice, the LVs showed regression after VEGF-C or VEGFR3 deletion, administration of the tyrosine kinase inhibitor sunitinib, or expression of VEGF-C/D trap, which also compromised the lymphatic drainage function. Conversely, an excess of VEGF-C induced meningeal lymphangiogenesis. The plasticity and regenerative potential of meningeal LVs should allow manipulation of cerebrospinal fluid drainage and neuropathological processes in the CNS. © 2017 Antila et al.

  6. Dove sta andando l'analisi musicale? Riflessioni sul VII EuroMac

    Directory of Open Access Journals (Sweden)

    Mario Baroni

    2014-01-01

    Full Text Available Come tutti i lettori della Rivista ormai sapranno, si è svolto a Roma dal 29 settembre al 2 ottobre di quest’anno, presso il Conservatorio di S. Cecilia, il settimo convegno europeo di analisi musicale (VII European Music Analysis Conference ossia VII EuroMac. Nel convegno, organizzato dal GATM e diretto da Giorgio Sanguinetti, sono state presentate 197 relazioni e svolti otto laboratori. Tutti i materiali sono stati riassunti in un volume (Programme and Abstract Book, Iter Edizioni di Subiaco curato da Egidio Pozzi e Antonio Cascelli.

  7. Employment discrimination implications of genetic screening in the workplace under Title VII and the Rehabilitation Act.

    Science.gov (United States)

    Canter, E F

    1984-01-01

    The emergence of genetic screening techniques will permit employers to exclude hypersusceptible individuals from potentially hazardous workplace environments. The denial of employment opportunities to these individuals, however, may constitute discrimination. This Note analyzes genetic screening cases with respect to currently available remedies contained in Title VII of the Civil Rights Act of 1964 and the Rehabilitation Act of 1973. The Note concludes that Title VII claims may succeed but only in limited circumstances and that Rehabilitation Act claims will encounter numerous obstacles to relief. Additionally, the Note discusses some of the implications of the use of genetic screening in the workplace.

  8. Confinement of Stellarator plasmas with neutral beam and RF heating in W VII-A

    International Nuclear Information System (INIS)

    Grieger, G.; Cattanei, G.; Dorst, D.

    1986-01-01

    WENDELSTEIN VII-A has been operated for ten years. It is a low-shear, high-aspect-ratio device. The confinement properties have been thoroughly studied for both ohmically heated and net-current free plasmas. For the latter case, NBI- and ECF-maintained plasmas were of particular importance. It was found that under optimized conditions the core of high-pressure, net-current free plasmas is mainly governed by collisional effects. The experiment will now be shut down for upgrading it into the Advanced Stellarator WEDNDELSTEIN VII-AS. (author)

  9. VII International scientific conference Radiation-thermal effects and processes in inorganic materials. Proceedings

    International Nuclear Information System (INIS)

    2010-01-01

    In the collection there are the reports of the VII International scientific conference and the VII All-Russian school-conference Radiation-thermal effects and processes in inorganic materials which were conducted on October 2-10, 2010, in Tomsk. The reports deal with new developments of charged particles high-intensity beam sources, high-temperature metrology of high-current beams and work materials, radiation-thermal stimulated effects and processes in inorganic materials, physical basics of technological processes, radiation-thermal technologies and equipment for their realization, allied branches of science and technology, specifically, nanotechnologies [ru

  10. Prophylactic Level VII Nodal Dissection as a Prognostic Factor in Papillary Thyroid Carcinoma: a Pilot Study of 27 Patients.

    Science.gov (United States)

    Fayek, Ihab Samy

    2015-01-01

    Prognostic value of prophylactic level VII nodal dissection in papillary thyroid carcinoma has been highlighted. A total of 27 patients with papillary thyroid carcinoma with N0 neck underwent total thyroidectomy with level VI and VII nodal dissection through same collar neck incision. Multicentricity, bilaterality, extrathyroidal extension, level VI and VII lymph nodes were studied as separate and independent prognostic factors for DFS at 24 months. 21 females and 6 males with a mean age of 34.6 years old, tumor size was 5-24 mm. (mean 12.4 mm.), multicentricity in 11 patients 2-4 foci (mean 2.7), bilaterality in 8 patients and extrathyroidal extension in 8 patients. Dissected level VI LNs 2-8 (mean 5 LNs) and level VII LNs 1-4 (mean 1.9). Metastatic level VI LNs 0-3 (mean 1) and level VII LNs 0-2 (mean 0.5). Follow-up from 6-51 months (mean 25.6) with 7 patients showed recurrence (3 local and 4 distant). Cumulative DFS at 24 months was 87.8% and was significantly affected in relation to bilaterality (p-valueVII positive ((p-valueVII nodal involvement. Level VII prophylactic nodal dissection is an important and integral prognostic factor in papillary thyroid carcinoma. A larger multicenter study is crucial to reach a satisfactory conclusion about the necessity and safety of this approach.

  11. Inhibition of thrombin generation by the zymogen factor VII: implications for the treatment of hemophilia A by factor VIIa

    NARCIS (Netherlands)

    van 't Veer, C.; Golden, N. J.; Mann, K. G.

    2000-01-01

    Factor VII circulates as a single chain inactive zymogen (10 nmol/L) and a trace ( approximately 10-100 pmol/L) circulates as the 2-chain form, factor VIIa. Factor VII and factor VIIa were studied in a coagulation model using plasma concentrations of purified coagulation factors with reactions

  12. Case report: a 70-year-old man with undiagnosed factor VII deficiency presented with acute ischemic stroke.

    Science.gov (United States)

    Ip, Hing-Lung; Chan, Anne Yin-Yan; Ng, Kit-Chung; Soo, Yannie Oi-Yan; Wong, Lawrence Ka-Sing

    2013-11-01

    Factor VII deficiency is an uncommon coagulation disorder that patient usually presents with bleeding diathesis, but thrombotic event has been reported. We report a case of unusual clinical presentation in a patient with undiagnosed factor VII deficiency who presented with acute ischemic stroke. Copyright © 2013 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  13. Newcastle disease outbreaks in recent years in Western Europe were caused by an old (VI) and a novel genotype (VII)

    DEFF Research Database (Denmark)

    Lomniczi, B.; Wehmann, E.; Herczeg, J.

    1998-01-01

    and Greece in the late 1960's and in Hungary in the early 1980's. In contrast, viruses that caused epizootics in Germany, Belgium, The Netherlands, Spain and Italy could be classified into a novel genotype (provisionally termed VII), hitherto undetected in Europe. It is possible that the genotype VII viruses...

  14. Emergency venting of pressure vessels

    International Nuclear Information System (INIS)

    Steinkamp, H.

    1995-01-01

    With the numerical codes developed for safety analysis the venting of steam vessel can be simulated. ATHLET especially is able to predict the void fraction depending on the vessel height. Although these codes contain a one-dimensional model they allow the description of complex geometries due to the detailed nodalization of the considered apparatus. In chemical reactors, however, the venting process is not only influenced by the flashing behaviour but additionally by the running chemical reaction in the vessel. Therefore the codes used for modelling have to consider the kinetics of the chemical reaction. Further multi-component systems and dissolving processes have to be regarded. In order to preduct the fluid- and thermodynamic process it could be helpful to use 3-dimensional codes in combination with the one-dimensional codes as used in nuclear industry to get a more detailed describtion of the running processes. (orig./HP)

  15. Development of Catamaran Fishing Vessel

    Directory of Open Access Journals (Sweden)

    A. Jamaluddin

    2010-11-01

    Full Text Available Multihull due to a couple of advantages has been the topic of extensive research work in naval architecture. In this study, a series of investigation of fishing vessel to save fuel energy was carried out at ITS. Two types of ship models, monohull (round bilge and hard chine and catamaran, a boat with two hulls (symmetrical and asymmetrical were developed. Four models were produced physically and numerically, tested (towing tank and simulated numerically (CFD code. The results of the two approaches indicated that the catamaran mode might have drag (resistance smaller than those of monohull at the same displacement. A layout of catamaran fishing vessel, proposed here, indicates the freedom of setting the deck equipments for fishing vessel.

  16. 33 CFR 90.3 - Pushing vessel and vessel being pushed: Composite unit.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pushing vessel and vessel being... HOMELAND SECURITY INLAND NAVIGATION RULES INLAND RULES: INTERPRETATIVE RULES § 90.3 Pushing vessel and vessel being pushed: Composite unit. Rule 24(b) of the Inland Rules states that when a pushing vessel and...

  17. 33 CFR 82.3 - Pushing vessel and vessel being pushed: Composite unit.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pushing vessel and vessel being... HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES 72 COLREGS: INTERPRETATIVE RULES § 82.3 Pushing vessel and vessel being pushed: Composite unit. Rule 24(b) of the 72 COLREGS states that when a pushing vessel and a...

  18. 76 FR 7757 - Hull Identification Numbers for Recreational Vessels

    Science.gov (United States)

    2011-02-11

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 181 [Docket No. USCG-2007-29236] Hull Identification Numbers for Recreational Vessels AGENCY: Coast Guard, DHS. ACTION: Follow-up to request for... expanded hull identification number (HIN). The Coast Guard's decision-making process included consideration...

  19. 19 CFR 4.90 - Simultaneous vessel transactions.

    Science.gov (United States)

    2010-04-01

    ... mentioned in this section and the conditions stated in the sections indicated in the list: 121 For the purposes of this part, an inward foreign voyage is completed at the port of final discharge of inbound... ports (§ 4.88). (b) When a vessel is engaged simultaneously in two or more such transactions, the master...

  20. Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation

    DEFF Research Database (Denmark)

    Nygaard, Rie; Hansen, Louise Valentin; Mokrosinski, Jacek

    2010-01-01

    Five highly conserved polar residues connected by a number of structural water molecules together with two rotamer micro-switches, TrpVI:13 and TyrVII:20, constitute an extended hydrogen bond network between the intracellular segments of TM-I, -II, -VI, and -VII of 7TM receptors. Molecular dynamics...... to apparently function as a catching trap for water molecules. Mutational analysis of the beta2-adrenergic receptor demonstrated that the highly conserved polar residues of the hydrogen bond network were all important for receptor signaling but served different functions, some dampening constitutive activity...... (AsnI:18, AspII:10, and AsnVII:13), whereas others (AsnVII:12 and AsnVII:16) located one helical turn apart and sharing a water molecule were shown to be essential for agonist-induced signaling. It is concluded that the conserved water hydrogen bond network of 7TM receptors constitutes an extended...

  1. Demonstration of resonant photopumping of Mo VII by Mo XII for a VUV laser near 600 Angstrom

    International Nuclear Information System (INIS)

    Ilcisin, K.J.; Aumayr, F.; Schwob, J.L.; Suckewer, S.

    1993-09-01

    We present data of experiments on the resonant photopumping of Mo VII by Mo XII as a method of generating a coherent VUV source near 600 angstrom. The experiment is based on a scheme proposed by Feldman and Reader in which the 4p 6 -- 4p 5 6s transition in Mo VII in resonantly photopumped by the 5s 2 S 1/2 -- 4p 2 P 1/2 transition in Mo XII. Results of the laser produced plasma experiments show the successful enhancement of the population of the Mo VII 4p 5 6s upper lasing level when pumped by an adjacent Mo VII plasma. No enhancement was seen in a control experiment where the Mo VII plasma was pumped by a Zr X plasma. Improvements of the intensity of the Mo XII pump source, achieved using an additional pump laser, lead to the generation of a population inversion for the VUV transition

  2. Containment vessel design and practice

    International Nuclear Information System (INIS)

    Bangash, Y.

    1983-01-01

    The state of the art of analysis and design of the concrete containment vessels required for BWR and PWR is reviewed. A step-by-step critical appraisal of the existing work is given. Elastic, inelastic and cracking conditions under extreme loads are fully discussed. Problems associated with these structures are highlighted. A three-dimensional finite element analysis is included to cater for service, overload and dynamic cracking of such structures. Missile impact and seismic effects are included in this work. The second analysis is known as the limit state analysis, which is given to design such vessels for any kind of load. (U.K.)

  3. Stress analysis of pressure vessels

    International Nuclear Information System (INIS)

    Kim, B.K.; Song, D.H.; Son, K.H.; Kim, K.S.; Park, K.B.; Song, H.K.; So, J.Y.

    1979-01-01

    This interim report contains the results of the effort to establish the stress report preparation capability under the research project ''Stress analysis of pressure vessels.'' 1978 was the first year in this effort to lay the foundation through the acquisition of SAP V structural analysis code and a graphic terminal system for improved efficiency of using such code. Software programming work was developed in pre- and post processing, such as graphic presentation of input FEM mesh geometry and output deformation or mode shope patterns, which was proven to be useful when using the FEM computer code. Also, a scheme to apply fracture mechanics concept was developed in fatigue analysis of pressure vessels. (author)

  4. 46 CFR 117.205 - Survival craft-vessels operating on limited coastwise routes.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Survival craft-vessels operating on limited coastwise... PASSENGERS LIFESAVING EQUIPMENT AND ARRANGEMENTS Number and Type of Survival Craft § 117.205 Survival craft... the survival craft required by §§ 117.204 (a) through (d) of this part, as applicable. (b) Each vessel...

  5. 76 FR 27897 - Security and Safety Zone Regulations, Large Passenger Vessel Protection, Captain of the Port...

    Science.gov (United States)

    2011-05-13

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2011-0342] Security and Safety Zone Regulations, Large Passenger Vessel Protection, Captain of the Port Columbia River... will enforce the security and safety zone in 33 CFR 165.1318 for large passenger vessels operating in...

  6. Grounding Damage to Conventional Vessels

    DEFF Research Database (Denmark)

    Lützen, Marie; Simonsen, Bo Cerup

    2003-01-01

    The present paper is concerned with rational design of conventional vessels with regard to bottom damage generated in grounding accidents. The aim of the work described here is to improve the design basis, primarily through analysis of new statistical data for grounding damage. The current regula...

  7. PLANNING VESSEL BODY SECTION PRODUCTION

    Directory of Open Access Journals (Sweden)

    A. G. Grivachevsky

    2015-01-01

    Full Text Available A problem of planning production of a vessel body section is considered. The problem is reduced to the classic Johnson’s tree-machine flow-shop scheduling problem. A genetic algorithm and computer experiment to compare efficiency of this algorithm and the algorithm of full enumeration are described.

  8. Pressure vessel and method therefor

    Science.gov (United States)

    Saunders, Timothy

    2017-09-05

    A pressure vessel includes a pump having a passage that extends between an inlet and an outlet. A duct at the pump outlet includes at least one dimension that is adjustable to facilitate forming a dynamic seal that limits backflow of gas through the passage.

  9. Commercial Passenger Fishing Vessel Fishery

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains the logbook data from U.S.A. Commercial Passenger Fishing Vessels (CPFV) fishing in the U.S.A. EEZ and in waters off of Baja California, from...

  10. Presidendi teenetemärgi pälvis viis spordiinimest

    Index Scriptorium Estoniae

    2008-01-01

    Vt. ka Linnaleht : Tartu 7. veebr., lk. 7. Eesti riigile osutatud teenete eest pälvisid president Toomas Hendrik Ilveselt teenetemärgi viis spordieluga seotud inimest: jalgpallikoondise ekstreenerid Jelle Goes ja Arno Pijpers, kergejõustikutreener Vésteinn Hafsteinsson, sõudetreener Tatjana Jaanson ning spordielu edendaja Nora Kutti. Juuresoleval fotol Jelle Goes

  11. Chemical Analysis of the Moon at the Surveyor VII Landing Site: Preliminary Results.

    Science.gov (United States)

    Turkevich, A L; Franzgrote, E J; Patterson, J H

    1968-10-04

    The alpha-scattering experiment aboard Surveyor VII has provided a chemical analysis of the moon in the area of the crater Tycho. The preliminary results indicate a chemical composition similar to that already found at two mare sites, but with a lower concentration of elements of the iron group (titanium through copper).

  12. Federal Programs Supporting Educational Change, Vol. VII: Factors Affecting Implementation and Continuation.

    Science.gov (United States)

    Berman, Paul; And Others

    This report is one of three volumes that describe the second phase of a study that examined the implementation of four federal change agent programs related to education. Phase 2 of the study focused on what happens to local projects in the two largest change agent programs--ESEA Title III and ESEA Title VII--when federal funding stops. This…

  13. Hormone therapy affects plasma measures of factor VII-activating protease in younger postmenopausal women

    DEFF Research Database (Denmark)

    Mathiasen, Jørn Sidelmann; Skouby, S.O.; Vitzthum, F.

    2010-01-01

    Objectives Current reviews indicate that hormone therapy (HT) has a protective role in coronary heart disease (CHD) in younger postmenopausal women, whereas HT contributes to CHD in older women Factor VII-activating protease (FSAP) is a serine protease that accumulates in unstable atherosclerotic...

  14. Synthesis and characterization of 18F-labeled active site inhibited factor VII (ASIS)

    DEFF Research Database (Denmark)

    Erlandsson, Maria; Nielsen, Carsten Haagen; Jeppesen, Troels Elmer

    2015-01-01

    Activated factor VII blocked in the active site with Phe-Phe-Arg-chloromethyl ketone (active site inhibited factor VII (ASIS)) is a 50-kDa protein that binds with high affinity to its receptor, tissue factor (TF). TF is a transmembrane glycoprotein that plays an important role in, for example......, thrombosis, metastasis, tumor growth, and tumor angiogenesis. The aim of this study was to develop an 18F-labeled ASIS derivative to assess TF expression in tumors. Active site inhibited factor VII was labeled using N-succinimidyl-4-[18F]fluorobenzoate, and the [18F]ASIS was purified on a PD-10 desalting...... column. The radiochemical yield was 25 ± 6%, the radiochemical purity was >97%, and the pseudospecific radioactivity was 35 ± 9 GBq/µmol. The binding efficacy was evaluated in pull-down experiments, which monitored the binding of unlabeled ASIS and [18F]ASIS to TF and to a specific anti-factor VII...

  15. Inherited coagulation factor VII and X deficiencies associated with severe bleeding diathesis: Molecular genetics and pathophysiology

    NARCIS (Netherlands)

    Borensztajn, K.; Spek, C. A.

    2005-01-01

    The rare inherited coagulation disorders are a fascinating group of diseases that have provided us with important insights into the structure and functions of their respective deficient proteins. Factor (F)VII deficiency is the commonest of these inherited disorders of coagulation, whereas FX

  16. Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage

    DEFF Research Database (Denmark)

    Mayer, Stephan A; Brun, Nikolai C; Begtrup, Kamilla

    2008-01-01

    BACKGROUND: Intracerebral hemorrhage is the least treatable form of stroke. We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes. METHODS: We randomly assigned 841...

  17. A ¤high-fat meal does not activate blood coagulation factor vii in minipigs

    DEFF Research Database (Denmark)

    Olsen, A. K.; Larsen, L. F.; Bladbjerg, E.-M.

    2001-01-01

    It is a matter of debate whether postprandial activation of blood coagulation factor VII (FVII) is associated with an increased risk of thrombosis. To clarify this question, an animal model in which consequences of dietary FVII activation can be studied in a more detailed way would be an important...

  18. The measurement and interpretation of Ne VII spectral line intensity ratios

    International Nuclear Information System (INIS)

    Lang, J.

    1983-03-01

    Results are presented for the measurement, using the branching ratios calibration method, of the spectral intensities of Ne VII lines emitted from a theta-pinch plasma whose electron temperature and density have been found by laser scattering and alternate techniques. (author)

  19. Plasma fibrinogen and factor VII concentrations in adults after prenatal exposure to famine

    NARCIS (Netherlands)

    Roseboom, T. J.; van der Meulen, J. H.; Ravelli, A. C.; Osmond, C.; Barker, D. J.; Bleker, O. P.

    2000-01-01

    To assess the effect of maternal malnutrition during different stages of gestation on plasma concentrations of fibrinogen and factor VII, we investigated 725 people, aged 50 years, born around the time of the Dutch famine 1944-5. After adjustment for sex, plasma fibrinogen concentrations differed by

  20. Plasma concentrations of blood coagulation factor VII measured by immunochemical and amidolytic methods

    DEFF Research Database (Denmark)

    Bladbjerg, E-M; Gram, J; Jespersen, J

    2000-01-01

    Ever since the coagulant activity of blood coagulation factor VII (FVII:C) was identified as a risk indicator of cardiac death, a large number of studies have measured FVII protein concentrations in plasma. FVII protein concentrations are either measured immunologically with an ELISA method (FVII...

  1. Law School Faculty Hiring under Title VII: How a Judge Might Decide a Disparate Impact Case.

    Science.gov (United States)

    Redlich, Norman

    1991-01-01

    A judicial opinion concerning law school violations of Title VII of the Civil Rights Act of 1964 in faculty hiring is presented. The case concerns a black candidate rejected for an entry-level tenure-track position. Issues cited include the law school's mission and stated reasons for not hiring the candidate. (MSE)

  2. Investigation of current drive possibilities with the present ICRH system in Wendelstein VII-AS

    International Nuclear Information System (INIS)

    Chiu, S.C.

    1990-01-01

    With the double antenna configuration, designed for first heating tests on W VII-AS, a maximum driven current of 390 A/MW coupled can be expected when using a frequency of 75 MHz and a phasing of π/2. (orig.)

  3. CASMO5 JENDL-4.0 and ENDF/B-VII.1beta4 libraries

    International Nuclear Information System (INIS)

    Rhodes, J.; Gheorghiu, N.; Ferrer, R.

    2012-01-01

    This paper details the generation of neutron data libraries for the CASMO5 lattice physics code based on the recently released JENDL-4.0 and ENDF/B-VII.1beta4 nuclear data evaluations. This data represents state-of-the-art nuclear data for late-2011. The key features of the new evaluations are briefly described along with the procedure for processing of this data into CASMO5, 586-energy group neutron data libraries. Finally some CASMO5 results for standard UO 2 and MOX critical experiments for the two new libraries and the current ENDF/B-VII.0 CASMO5 library are presented including the B and W 1810 series, DIMPLE S06A, S06B, TCA reflector criticals with iron plates and the PNL-30-35 MOX criticals. The results show that CASMO5 with the new libraries is performing well for these criticals with a very slight edge in results to the JENDL-4.0 nuclear data evaluation over the ENDF/B-VII.1beta4 evaluation. Work is currently underway to generate a CASMO5 library based on the final ENDF/B-VII.R1 evaluation released Dec. 22, 2011. (authors)

  4. Analysis of time series for postal shipments in Regional VII East Java Indonesia

    Science.gov (United States)

    Kusrini, DE; Ulama, B. S. S.; Aridinanti, L.

    2018-03-01

    The change of number delivery goods through PT. Pos Regional VII East Java Indonesia indicates that the trend of increasing and decreasing the delivery of documents and non-documents in PT. Pos Regional VII East Java Indonesia is strongly influenced by conditions outside of PT. Pos Regional VII East Java Indonesia so that the prediction the number of document and non-documents requires a model that can accommodate it. Based on the time series plot monthly data fluctuations occur from 2013-2016 then the model is done using ARIMA or seasonal ARIMA and selected the best model based on the smallest AIC value. The results of data analysis about the number of shipments on each product sent through the Sub-Regional Postal Office VII East Java indicates that there are 5 post offices of 26 post offices entering the territory. The largest number of shipments is available on the PPB (Paket Pos Biasa is regular package shipment/non-document ) and SKH (Surat Kilat Khusus is Special Express Mail/document) products. The time series model generated is largely a Random walk model meaning that the number of shipment in the future is influenced by random effects that are difficult to predict. Some are AR and MA models, except for Express shipment products with Malang post office destination which has seasonal ARIMA model on lag 6 and 12. This means that the number of items in the following month is affected by the number of items in the previous 6 months.

  5. Correction of murine mucopolysaccharidosis VII by a human. beta. -glucuronidase transgene

    Energy Technology Data Exchange (ETDEWEB)

    Kyle, J.W.; Vogler, C.; Hoffmann, J.W.; Sly, W.S. (St. Louis Univ. School of Medicine, MO (USA)); Birkenmeier, E.H.; Gwynn, B. (Jackson Laboratory, Bar Harbor, ME (USA))

    1990-05-01

    The authors recently described a murine model for mucopolysaccharidosis VII in mice that have an inherited deficiency of {beta}-glucuronidase. Affected mice, of genotype gus{sup mps}/gus{sup mps}, present clinical manifestations similar to those of humans with mucopolysaccharidosis VII (Sly syndrome) and are shown here to have secondary elevations of other lysosomal enzymes. The mucopolysaccharidosis VII phenotype in both species includes dwarfism, skeletal deformities, and premature death. Lysosome storage is visualized within enlarged vesicles and correlates biochemically with accumulation of undegraded and partially degraded glycosaminoglycans. In this report they describe the consequences of introducing the human {beta}-glucuronidase gene, GUSB, into gus{sup mps}/gus{sup mps} mice that produce virtually no murine {beta}-glucuronidase. Transgenic mice homozygous for the mucopolysaccharidosis VII mutation expressed high levels of human {beta}-glucuronidase activity in all tissues examined and were phenotypically normal. Biochemically, both the intralysosomal storage of glycosaminoglycans and the secondary elevation of other acid hydrolases were corrected. These findings demonstrate that the GUSB transgene is expressed in gus{sup mps}/gus{sup mps} mice and that human {beta}-glucuronidase corrects the murine mucopolysaccharidosis storage disease.

  6. Vittorio De Sica viis meistritööd / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2008-01-01

    DVD-st "Vittorio De Sica Masterpiece Collection", kus on peal itaalia filmirežissööri Vittorio De Sica viis teost: "Jalgratavargad" ("Ladri di biciclette", 1948), "Ime Milanos" ("Miraclo a milano", 1951), "Umberto D." (1952), "Eile täna, homme" ("Ieri, oggi, domani", 1963), "Ajatu filmikunst" ("Cinema senza tempo: Cosi e la vita", 2001)

  7. Association of protein Z and factor VII gene polymorphisms with risk ...

    Indian Academy of Sciences (India)

    Protein Z (PZ) and factor (F) VII are two important factors in the clotting pathway ..... found in NCBI (http://www.ncbi.nlm.nih.gov/projects/SNP), chosen from the largest population .... power of this population-based case–control study was lim-.

  8. Sarah J. Hale High School Project SABER. ESEA Title VII. Final Evaluation Report, 1979-80.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Office of Educational Evaluation.

    This is an evaluation of a Title VII Bilingual Program conducted at a New York City High School in 1979-80. The report contains information on the program goals and objectives, the school site, and the student characteristics. Aspects of the instructional component discussed include programming, mainstreaming, and program funding.…

  9. Factor VII-activating protease : Unraveling the release and regulation of dead cell nuclear damps

    NARCIS (Netherlands)

    Marsman, G.

    2017-01-01

    Upon inflammation, uncleared dying cells are an important source of pro-inflammatory damage-associated molecular patterns (DAMPs). Major DAMPs are histones and double-stranded DNA, which together form chromatin. Factor VII-activating protease (FSAP) is activated upon contact with dead cells, and its

  10. Safety and Equality at Odds: OSHA and Title VII Clash over Health Hazards in the Workplace.

    Science.gov (United States)

    Crowell, Donald R.; Copus, David A.

    1978-01-01

    Discusses the legal problems presented by job health hazards which have a different effect on men and women. Where methods of eliminating or minimizing exposure, as required by the Occupational Safety and Health Act, affect only one sex, the provisions of Title VII of the Civil Rights Act may be violated. (MF)

  11. "Põrgu wärk" võitis Balti teatrifestivalil viis auhinda

    Index Scriptorium Estoniae

    2006-01-01

    Balti teatrifestivalil "OmaDraama 2006" nähtud etendustest said viis auhinda eestlased - Mart Kivastik näidendi "Põrgu Wärk" eest, Hendrik Toompere lavastuse eest, Harriet Toompere naisosatäitmise eest, Jan Uuspõld Wiiralti kehastamise eest ning Margus Prangel Tuglase osa eest. Ka teistest festivalil auhinnasaajatest

  12. Eesti lavastus "Põrgu wärk" võitis Balti teatrifestivalil viis auhinda

    Index Scriptorium Estoniae

    2006-01-01

    Balti teatrifestivalil "OmaDraama 2006" nähtud etendustest said viis auhinda eestlased - Mart Kivastik näidendi "Põrgu Wärk" eest, Hendrik Toompere lavastuse eest, Harriet Toompere naisosatäitmise eest, Jan Uuspõld Wiiralti kehastamise eest ning Margus Prangel Tuglase osa eest

  13. Maritime Training Serbian Autonomous Vessel Protection Detachment

    Directory of Open Access Journals (Sweden)

    Šoškić Svetislav D.

    2014-06-01

    Full Text Available The crisis in Somalia has caused appearance of piracy at sea in the Gulf of Aden and the Western Indian Ocean. Somali pirates have become a threat to economic security of the world because almost 30 percent of world oil and 20 percent of global trade passes through the Gulf of Aden. Solving the problem of piracy in this part of the world have included international organizations, institutions, military alliances and the states, acting in accordance with international law and UN Security Council resolutions. The European Union will demonstrate the application of a comprehensive approach to solving the problem of piracy at sea and the crisis in Somalia conducting naval operation — EU NAVFOR Atalanta and operation EUTM under the Common Security and Defense Policy. The paper discusses approaches to solving the problem of piracy in the Gulf of Aden and the crisis in Somalia. Also, the paper points to the complexity of the crisis in Somalia and dilemmas correctness principles that are applied to solve the problem piracy at sea. One of goals is protections of vessels of the World Food Programme (WFP delivering food aid to displaced persons in Somalia. Republic of Serbia joined in this mission and trained and sent one a autonomous team in this military operation for protection WFP. This paper consist the problem of modern piracy, particularly in the area of the Horn of Africa became a real threat for the safety of maritime ships and educational process of Serbian Autonomous vessel protection detachment. Serbian Military Academy adopted and developed educational a training program against piracy applying all the provisions and recommendations of the IMO conventions and IMO model courses for Serbian Autonomous vessel protection detachment.

  14. Corrosion of vessel steel during its interaction with molten corium

    International Nuclear Information System (INIS)

    Bechta, S.V.; Khabensky, V.B.; Vitol, S.A.; Krushinov, E.V.; Granovsky, V.S.; Lopukh, D.B.; Gusarov, V.V.; Martinov, A.P.; Martinov, V.V.; Fieg, G.; Tromm, W.; Bottomley, D.; Tuomisto, H.

    2006-01-01

    An experimental examination of the cooled vessel steel corrosion during the interaction with molten corium is presented. The experiments have been conducted on 'Rasplav-2' test facility and followed up with physico-chemical and metallographic analyses of melt samples and corium-specimen ingots. The results discussed in the first part of the paper have revealed specific corrosion mechanisms for air and inert atmosphere above the melt. Models have been proposed based on this information and approximate curves constructed for the estimation of the corrosion rate or corrosion depth of vessel steel in conditions simulated by the experiments

  15. Corrosion of vessel steel during its interaction with molten corium

    Energy Technology Data Exchange (ETDEWEB)

    Bechta, S.V. [Scientific Research Technological Institute (NITI), Sosnovy Bor of Leningrad Oblast 188540 (Russian Federation)]. E-mail: bechta@sbor.spb.su; Khabensky, V.B. [Scientific Research Technological Institute (NITI), Sosnovy Bor of Leningrad Oblast 188540 (Russian Federation); Vitol, S.A. [Scientific Research Technological Institute (NITI), Sosnovy Bor of Leningrad Oblast 188540 (Russian Federation); Krushinov, E.V. [Scientific Research Technological Institute (NITI), Sosnovy Bor of Leningrad Oblast 188540 (Russian Federation); Granovsky, V.S. [Scientific Research Technological Institute (NITI), Sosnovy Bor of Leningrad Oblast 188540 (Russian Federation); Lopukh, D.B. [SPb Electrotechnical University (SpbGETU), Professor Popov str., b.5/3, 197376 St. Petersburg (Russian Federation); Gusarov, V.V. [Institute of Silicate Chemistry of Russian Academy of Science (ISC of RAS), Odoevsky str., b. 24/2, 199155 St. Petersburg (Russian Federation); Martinov, A.P. [SPb Electrotechnical University (SpbGETU), Professor Popov str., b.5/3, 197376 St. Petersburg (Russian Federation); Martinov, V.V. [Scientific Research Technological Institute (NITI), Sosnovy Bor of Leningrad Oblast 188540 (Russian Federation); Fieg, G. [Forshungszentrum Karlsruhe (FZK), Institut fur Neutronenphysik and Reaktortechnik, Postfach 3640, D-78021 Karlsruhe (Germany); Tromm, W. [Forshungszentrum Karlsruhe (FZK), Institut fur Neutronenphysik and Reaktortechnik, Postfach 3640, D-78021 Karlsruhe (Germany); Bottomley, D. [Europaeische Kommission, General Direktion GFS, Institut fuer Transurane (ITU), Postfach 2340, 76125 Karlsruhe (Germany); Tuomisto, H. [Fortum Engineering Ltd. 00048 FORTUM, Rajatorpantie 8, Vantaa (Finland)

    2006-07-15

    An experimental examination of the cooled vessel steel corrosion during the interaction with molten corium is presented. The experiments have been conducted on 'Rasplav-2' test facility and followed up with physico-chemical and metallographic analyses of melt samples and corium-specimen ingots. The results discussed in the first part of the paper have revealed specific corrosion mechanisms for air and inert atmosphere above the melt. Models have been proposed based on this information and approximate curves constructed for the estimation of the corrosion rate or corrosion depth of vessel steel in conditions simulated by the experiments.

  16. Efficient Vessel Tracking  with Accuracy Guarantees

    DEFF Research Database (Denmark)

    Redoutey, Martin; Scotti, Eric; Jensen, Christian Søndergaard

    2008-01-01

    Safety and security are top concerns in maritime navigation, particularly as maritime traffic continues to grow and as crew sizes are reduced. The Automatic Identification System (AIS) plays a key role in regard to these concerns. This system, whose objective is in part to identify and locate ves...... accuracies at lower communication costs. The techniques employ movement predictions that are shared between vessels and the VTS. Empirical studies with a prototype implementation and real vessel data demonstrate that the techniques are capable of significantly improving the AIS....

  17. Integral reactor vessel related to power reactor safety

    International Nuclear Information System (INIS)

    Widart, J.; Scailteur, A.

    1978-01-01

    Integral design applied to PWR pressure vessels allows to reach a high level of safety because: 1) it presents a better balance of the material in the geometry, resulting in an improved stress level (mainly faulted condition loadings); 2) location and geometry of the welds are designed in order to get a very sound pressure boundary of the upper part of the vessel; 3) the new location and geometry of the welds allow an easy ISI in such a way that ambiguity surrounding defect size or locaton is practically suppressed. (author)

  18. Development of PWR pressure vessel steels

    International Nuclear Information System (INIS)

    Druce, S.; Edwards, B.

    1982-01-01

    Requirements to be met by vessel steels for pressurized water reactors are analyzed. Chemicat composition of low-alloyed steels, mechanical properties of sheets and forgings made of these steels and changes in the composition and properties over the wall thickness of the reactor vessel are presented. Problems of the vessel manufacturing including welding and heat treatment processes of sheets and forgings are considered. Special attention is paid to steel embrittlement during vessel fabrication and operation (radiation embrittlement, thermal embrittlement). The role of non-metal inclusions and their effect on anisotropy of fracture toughness is discussed. Possible developments of vessel steels and procedures for producing reactor vessels are reviewed

  19. Development of PWR pressure vessel steels

    Energy Technology Data Exchange (ETDEWEB)

    Druce, S.; Edwards, B.

    1982-01-01

    Requirements to be met by vessel steels for pressurized water reactors are analyzed. Chemicat composition of low-alloyed steels, mechanical properties of sheets and forgings made of these steels and changes in the composition and properties over the wall thickness of the reactor vessel are presented. Problems of the vessel manufacturing including welding and heat treatment processes of sheets and forgings are considered. Special attention is paid to steel embrittlement during vessel fabrication and operation (radiation embrittlement, thermal embrittlement). The role of non-metal inclusions and their effect on anisotropy of fracture toughness is discussed. Possible developments of vessel steels and procedures for producing reactor vessels are reviewed.

  20. System for cooling the upper wall of a nuclear reactor vessel

    International Nuclear Information System (INIS)

    Pailla, Henri; Schaller, Karl; Vidard, Michel.

    1974-01-01

    A system for cooling the upper wall of the main vessel of a fast neutron reactor is described. This vessel is suspended from an upper shield by the upper wall. It includes coils carrying a coolant which are immersed in an intermediate liquid bathing the wall and contained in a tank integral with the vessel. At least one of the two cooling and intermediate liquids is a liquid metal. The main vessel is contained in a safety vessel, the space between the main and safety vessels is occluded in its upper part by an insulating shield placed under the tank. There is a liquid metal seal between the upper wall and the upper shield under the tank. This system has been specially designed for sodium cooled fast neutron reactors [fr

  1. Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications.

    Science.gov (United States)

    De Bock, Katrien; Cauwenberghs, Sandra; Carmeliet, Peter

    2011-02-01

    As a result of excessive production of angiogenic molecules, tumor vessels become abnormal in structure and function. By impairing oxygen delivery, abnormal vessels fuel a vicious cycle of non-productive angiogenesis, which creates a hostile microenvironment from where tumor cells escape through leaky vessels and which renders tumors less responsive to chemoradiation. While anti-angiogenic strategies focused on inhibiting new vessel growth and destroying pre-existing vessels, clinical studies showed modest anti-tumor effects. For many solid tumors, anti-VEGF treatment offers greater clinical benefit when combined with chemotherapy. This is partly due to a normalization of the tumor vasculature, which improves cytotoxic drug delivery and efficacy and offers unprecedented opportunities for anti-cancer treatment. Here, we overview key novel molecular players that induce vessel normalization. Copyright © 2010 Elsevier Ltd. All rights reserved.

  2. The 1500 MW fast breeder reactor the double envelope-vessel anchored in concrete

    International Nuclear Information System (INIS)

    Bolvin, M.

    1981-01-01

    This paper givers an account of EDF investigations to reduce the investment costs of the 1500 MW Fast Reactor (RNR 1500) without prejudice to the safety requirements. It deals with the double envelope-vessel, designed to minimize radiation consequences in the event of accidental leakage in the main vessel. In the Fast Reactors in operation (PHOENIX), under construction (CRYS-MALVILLE), and under project (NR 1500), the double envelope-steel vessel hangs down from the upper part of the reactor block, its weight being approximately 300 t. In the new design, the vessel is fixed into the concrete which supports the main vessel, by means of steel anchors. A thermal insulation isolates it from the main vessel. The installation of coils in the concrete, next to the lining, allows for water circulation to cool the concrete. (orig./GL)

  3. Pengembangan LKS Untuk Melatih Kemampuan Berpikir Kritis dalam Mata Pelajaran Matematika di Kelas VII SMP

    Directory of Open Access Journals (Sweden)

    Puji Astuti

    2017-10-01

    Full Text Available Tujuan pembelajaran matematika adalah untuk melatih siswa berpikir kritis. Oleh karena itu, perlu dikembangkan Lembar Kerja Siswa (LKS untuk melatih kemampuan berpikir kritis siswa. Penelitian ini bertujuan untuk menghasilkan LKS yang berkarakteristik untuk melatih kemampuan berpikir kritis siswa kelas VII SMP. Sampel pada penelitian ini adalah kelas VII7 berjumlah 30 siswa semester II SMP Negeri 9 Palembang. Metode penelitian yang digunakan adalah metode penelitian pengembangan yang terdiri dari analisis, desain, evaluasi dan revisi. Pengumpulan data dilakukan dengan cara prototyping.  Prototyping dilakukan untuk mengetahui bagaimana karakteristik LKS untuk melatih kemampuan berpikir kritis siswa kelas VII SMP. Hasil penelitian ini adalah karakteristik LKS untuk melatih kemampuan berpikir kritis siswa kelas VII SMP. Kata kunci: Kemampuan berpikir kritis, Lembar Kerja Siswa    Mathematics learning aims to develop students critical thinking. Therefore, it is necessary to develop Student Worksheet to train students' critical thinking skills. This research aims to develop student worksheet that has characteristics of critical thinking skill for 7th grade Junior High School students (SMP. The sample in this research is VII7 class with 30 students of the second semester of SMP Negeri 9 Palembang. The research method used is a development research method that consists of analysis, design, evaluation and revision. Data collection is done by prototyping. Prototyping was used to find out how the characteristics of student worksheet to develop critical thinking ability of grade  7th students. The result of this research is characteristic of student worksheet to develop critical thinking ability of 7th grade Junior High School student. Keywords: critical thinking ability, student worksheet

  4. Shielding performance of the NET vacuum vessel

    International Nuclear Information System (INIS)

    Arkuszewski, J.J.; Jaeger, J.F.

    1988-01-01

    To corroborate 1-D deterministic shielding calculations on the Next European Torus (NET) vacuum vessel/shield and shielding blanket, 3-D Monte Carlo calculations have been done with the MCNP code. This should provide information on the poloidal and the toroidal variations. Plasma source simulation and the geometrical model are described, as are other assumptions. The calculations are based on the extended plasma power of 714 MW. The results reported here are the heat deposition in various parts of the device, on the one hand, and the neutron and photon currents at the outer boundary of the vacuum vessel, on the other hand. The latter are needed for the detailed design of the super-conducting magnetic coils. A reasonable statistics has been obtained on the outboard side of the torus, though this cannot be said for the inboard side. The inboard is, however, much more toroidally symmetric than the outboard, so that other methods could be applied such as 2-D deterministic calculations, for instance. (author) 4 refs., 44 figs., 42 tabs

  5. Multi-purpose deployer for ITER in-vessel maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chang-Hwan, E-mail: Chang-Hwan.CHOI@iter.org [ITER Organization, Route de Vinon-sur-Verdon, 13115 St Paul lez Durance (France); Tesini, Alessandro; Subramanian, Rajendran [ITER Organization, Route de Vinon-sur-Verdon, 13115 St Paul lez Durance (France); Rolfe, Alan; Mills, Simon; Scott, Robin; Froud, Tim; Haist, Bernhard; McCarron, Eddie [Oxford Technologies Ltd., 7 Nuffield Way, Abingdon, OXON (United Kingdom)

    2015-10-15

    Highlights: • ITER RH system called as the multi-purpose deployer (MPD) is introduced. • The MPD performs dust and tritium inventory control, in-service inspection. • The MPD performs leak localization, in-vessel diagnostics maintenance. • The MPD has nine degrees of freedom with a payload capacity up to 2 tons. - Abstract: The multi-purpose deployer (MPD) is a general purpose in-vessel remote handling (RH) system in the ITER RH system. The MPD provides the means for deployment and handling of in-vessel tools or components inside the vacuum vessel (VV) for dust and tritium inventory control, in-service inspection, leak localization, and in-vessel diagnostics. It also supports the operation of blanket first wall maintenance and neutral beam duct liner module maintenance operations. This paper describes the concept design of the MPD. The MPD is a cask based system, i.e. it stays in the hot cell building during the machine operation, and is deployed to the VV using the cask system for the in-vessel operations. The main part of the MPD is the articulated transporter which provides transportation and positioning of the in-vessel tools or components. The articulated transporter has nine degrees of freedom with a payload capacity up to 2 tons. The articulated transporter can cover the whole internal surface of the VV by switching between the four equatorial RH ports. Additionally it can use two non-RH equatorial ports to transfer large tools or components. A concept for in-cask tool exchange is developed which minimizes the cask transportation by allowing the MPD to stay in the VV during the tool exchange.

  6. [Stem and progenitor cells in biostructure of blood vessel walls].

    Science.gov (United States)

    Korta, Krzysztof; Kupczyk, Piotr; Skóra, Jan; Pupka, Artur; Zejler, Paweł; Hołysz, Marcin; Gajda, Mariusz; Nowakowska, Beata; Barć, Piotr; Dorobisz, Andrzej T; Dawiskiba, Tomasz; Szyber, Piotr; Bar, Julia

    2013-09-18

    Development of vascular and hematopoietic systems during organogenesis occurs at the same time. During vasculogenesis, a small part of cells does not undergo complete differentiation but stays on this level, "anchored" in tissue structures described as stem cell niches. The presence of blood vessels within tissue stem cell niches is typical and led to identification of niches and ensures that they are functioning. The three-layer biostructure of vessel walls for artery and vein, tunica: intima, media and adventitia, for a long time was defined as a mechanical barrier between vessel light and the local tissue environment. Recent findings from vascular biology studies indicate that vessel walls are dynamic biostructures, which are equipped with stem and progenitor cells, described as vascular wall-resident stem cells/progenitor cells (VW-SC/PC). Distinct zones for vessel wall harbor heterogeneous subpopulations of VW-SC/PC, which are described as "subendothelial or vasculogenic zones". Recent evidence from in vitro and in vivo studies show that prenatal activity of stem and progenitor cells is not only limited to organogenesis but also exists in postnatal life, where it is responsible for vessel wall homeostasis, remodeling and regeneration. It is believed that VW-SC/PC could be engaged in progression of vascular disorders and development of neointima. We would like to summarize current knowledge about mesenchymal and progenitor stem cell phenotype with special attention to distribution and biological properties of VW-SC/PC in biostructures of intima, media and adventitia niches. It is postulated that in the near future, niches for VW-SC/PC could be a good source of stem and progenitor cells, especially in the context of vessel tissue bioengineering as a new alternative to traditional revascularization therapies.

  7. Stem and progenitor cells in biostructure of blood vessel walls

    Directory of Open Access Journals (Sweden)

    Krzysztof Korta

    2013-09-01

    Full Text Available Development of vascular and hematopoietic systems during organogenesis occurs at the same time. During vasculogenesis, a small part of cells does not undergo complete differentiation but stays on this level, “anchored” in tissue structures described as stem cell niches. The presence of blood vessels within tissue stem cell niches is typical and led to identification of niches and ensures that they are functioning. The three-layer biostructure of vessel walls for artery and vein, tunica: intima, media and adventitia, for a long time was defined as a mechanical barrier between vessel light and the local tissue environment. Recent findings from vascular biology studies indicate that vessel walls are dynamic biostructures, which are equipped with stem and progenitor cells, described as vascular wall-resident stem cells/progenitor cells (VW-SC/PC. Distinct zones for vessel wall harbor heterogeneous subpopulations of VW-SC/PC, which are described as “subendothelial or vasculogenic zones”. Recent evidence from in vitro and in vivo studies show that prenatal activity of stem and progenitor cells is not only limited to organogenesis but also exists in postnatal life, where it is responsible for vessel wall homeostasis, remodeling and regeneration. It is believed that VW-SC/PC could be engaged in progression of vascular disorders and development of neointima. We would like to summarize current knowledge about mesenchymal and progenitor stem cell phenotype with special attention to distribution and biological properties of VW-SC/PC in biostructures of intima, media and adventitia niches. It is postulated that in the near future, niches for VW-SC/PC could be a good source of stem and progenitor cells, especially in the context of vessel tissue bioengineering as a new alternative to traditional revascularization therapies.

  8. Multi-layered vessel for radioactive waste

    International Nuclear Information System (INIS)

    Ouchi, Yasuyoshi; Okagawa, Seigo; Tamaoki, Hidehiro.

    1990-01-01

    A pressure equalizing valve is disposed to a metal container and the inner surface of which is coated with lining material containing quickly curing cement, aggregates and polymer emulsion each by a specific amount. As the aggregates, those of 0.6 to 0.2 mm grain size are preferable and they are used by from 50 to 300 parts by weight based on 100 parts by weight of quickly curing cement. Further, an aqueous emulsion of acryl type resin, etc. is used as the polymer emulsion by from 80 to 300 parts by weight based on 100 parts by weight of the quickly curing cement. Since the wall of the layered vessel is relatively thin, it is deformed by the water pressure in the sea water, but the difference pressure is moderated and equalized with elapse of time owing to the effect of the equalizing valve and causes no destruction. Further, since alkali is contained in the cement ingredients do not leach, an alkaline atmosphere is maintained at the vicinity of the container and sufficient anti-rust effect can be obtained and maintained. (T.M.)

  9. Experimental Investigation of Creep Behavior of Reactor Vessel Lower Head

    International Nuclear Information System (INIS)

    Chu, T.Y.; Pilch, M.; Bentz, J.H.; Behbahani, A.

    1999-01-01

    The authors report a study which aimed at experimentally and numerically investigating and characterizing the failure of a reactor pressure vessel (RPV) lower head due to thermal and pressure loads generated by a severe accident. They present the experimental apparatus which is based on a scaled version of the lower part of a TMI-like reactor pressure vessel without vessel skirt. They report and comment the results obtained during the first five experiments: uniform heating and non penetrations, centre-peaked heat flux and no penetrations, edge-peaked heat flux and no penetrations, uniform heating with penetrations, edge-peaked heat flux with penetrations. They compare the third and fifth experience (those with edge-peaked heat flux)

  10. Closure system of a vessel made of prestressed concrete

    International Nuclear Information System (INIS)

    Audibert, Alain

    1974-01-01

    The present invention relates to removable plugs of prestressed concrete which can be fitted to every type of closed high pressure vessels and especially to the cylindrical vessels of nuclear reactors. The method involved permits the plug to be fitted to the vessel through both radial and axial prestress. In this purpose, said invention proposes removable prestress ribs fitted inside sheaths in the plug and extending throughout the upper part of the bearing surfaces of the plug, said ribs being regularly arranged along the generators of an hyperboloid of one sheet. Owing to this important feature, that is to say said inclination of the ribs in accordance with the generators of said hyperboloid, said rib inclination can be changed on requirement for each realization [fr

  11. Design Procedure on Stud Bolt for Reactor Vessel Assembly

    International Nuclear Information System (INIS)

    Kim, Jong-Wook; Lee, Gyu-Mahn; Jeoung, Kyeong-Hoon; Kim, Tae-Wan; Park, Keun-Bae; Kim, Keung-Koo

    2008-10-01

    The reactor pressure vessel flange is welded to the upper part of reactor pressure vessel, and there are stud holes to mount the closure head with stud bolts. The surface mating the closure head is compressed with O-ring, which acts as a sealing gasket to prevent coolant leakage. Bolted flange connections perform a very important structural role in the design of a reactor pressure vessel. Their importance stems from two important functions: (a) maintenance of the structural integrity of the connection itself, and (b) prevention of leakage through the O-ring preloaded by stud bolts. In the present study, an evaluation procedure for the design of stud bolt is developed to meet ASME code requirements. The developed design procedure could provide typical references in the development of advanced reactor design in the future

  12. Computational scheme for transient temperature distribution in PWR vessel wall

    International Nuclear Information System (INIS)

    Dedovic, S.; Ristic, P.

    1980-01-01

    Computer code TEMPNES is a part of joint effort made in Gosa Industries in achieving the technique for structural analysis of heavy pressure vessels. Transient heat conduction problems analysis is based on finite element discretization of structures non-linear transient matrix formulation and time integration scheme as developed by Wilson (step-by-step procedure). Convection boundary conditions and the effect of heat generation due to radioactive radiation are both considered. The computation of transient temperature distributions in reactor vessel wall when the water temperature suddenly drops as a consequence of reactor cooling pump failure is presented. The vessel is treated as as axisymmetric body of revolution. The program has two finite time element options a) fixed predetermined increment and; b) an automatically optimized time increment for each step dependent on the rate of change of the nodal temperatures. (author)

  13. Oxidation of triclosan by permanganate (Mn(VII)): importance of ligands and in situ formed manganese oxides.

    Science.gov (United States)

    Jiang, Jin; Pang, Su-Yan; Ma, Jun

    2009-11-01

    Experiments were conducted to examine permanganate (Mn(VII); KMnO(4)) oxidation of the widely used biocide triclosan (one phenolic derivative) in aqueous solution at pH values of 5-9. Under slightly acidic conditions, the reactions displayed autocatalysis, suggesting the catalytic role of in situ formed MnO(2). This was further supported by the promoting effects of the addition of preformed MnO(2) colloids on Mn(VII) oxidations of triclosan and two other selected phenolics (i.e., phenol and 2,4-dichlorophenol), as well as p-nitrophenol which otherwise showed negligible reactivity toward Mn(VII) and MnO(2) colloids, respectively. Surprisingly, phosphate buffer significantly enhanced Mn(VII) oxidation of triclosan, as well as phenol and 2,4-dichlorophenol over a wide pH range. Further, several other selected ligands (i.e., pyrophosphate, EDTA, and humic acid) also exerted oxidation enhancement, supporting a scenario where highly active aqueous manganese intermediates (Mn(INT)(aq)) formed in situ upon Mn(VII) reduction might be stabilized to a certain extent in the presence of ligands and subsequently involved in further oxidation of target phenolics, whereas without stabilizing agents Mn(INT)(aq) autodecomposes or disproportionates spontaneously. The effectiveness of Mn(VII) for the oxidative removal of triclosan in natural water and wastewater was confirmed. Their background matrices were also found to accelerate Mn(VII) oxidation of phenolics.

  14. Study of the efficiency of the anti-convective thermal barrier of the Super-Phenix vessels inter space

    International Nuclear Information System (INIS)

    Durin, M.; Mejane, A.

    1983-08-01

    In the LMFBR Phenix reactor, the junction between the primary vessel and the roof slab is a region of large thermal gradients. In order to limit the gradient in the primary vessel, a thermal barrier has been installed between the primary and the safety vessel. The purpose of this barrier is to prevent the penetration of hot gas in the upper part of the vessels inter space. Experimental results have been obtained on a full scale model representing a 25 0 vessel sector of the reactor. Different geometrical configurations have been tested for a large range of boundary condition: - perfectly tight barrier - no thermal barrier; - simulation of leakages on the barrier [fr

  15. Pseudane-VII Isolated from Pseudoalteromonas sp. M2 Ameliorates LPS-Induced Inflammatory Response In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Mi Eun Kim

    2017-11-01

    Full Text Available The ocean is a rich resource of flora, fauna, food, and biological products. We found a wild-type bacterial strain, Pseudoalteromonas sp. M2, from marine water and isolated various secondary metabolites. Pseudane-VII is a compound isolated from the Pseudoalteromonas sp. M2 metabolite that possesses anti-melanogenic activity. Inflammation is a response of the innate immune system to microbial infections. Macrophages have a critical role in fighting microbial infections and inflammation. Recent studies reported that various compounds derived from natural products can regulate immune responses including inflammation. However, the anti-inflammatory effects and mechanism of pseudane-VII in macrophages are still unknown. In this study, we investigated the anti-inflammatory effects of pseudane-VII. In present study, lipopolysaccharide (LPS-induced nitric oxide (NO production was significantly decreased by pseudane-VII treatment at 6 μM. Moreover, pseudane-VII treatment dose-dependently reduced mRNA levels of pro-inflammatory cytokines including inos, cox-2, il-1β, tnf-α, and il-6 in LPS-stimulated macrophages. Pseudane-VII also diminished iNOS protein levels and IL-1β secretion. In addition, Pseudane-VII elicited anti-inflammatory effects by inhibiting ERK, JNK, p38, and nuclear factor (NF-κB-p65 phosphorylation. Consistently, pseudane-VII was also shown to inhibit the LPS-stimulated release of IL-1β and expression of iNOS in mice. These results suggest that pseudane-VII exerted anti-inflammatory effects on LPS-stimulated macrophage activation via inhibition of ERK, JNK, p38 MAPK phosphorylation, and pro-inflammatory gene expression. These findings may provide new approaches in the effort to develop anti-inflammatory therapeutics.

  16. Pseudane-VII Isolated from Pseudoalteromonas sp. M2 Ameliorates LPS-Induced Inflammatory Response In Vitro and In Vivo.

    Science.gov (United States)

    Kim, Mi Eun; Jung, Inae; Lee, Jong Suk; Na, Ju Yong; Kim, Woo Jung; Kim, Young-Ok; Park, Yong-Duk; Lee, Jun Sik

    2017-11-01

    The ocean is a rich resource of flora, fauna, food, and biological products. We found a wild-type bacterial strain, Pseudoalteromonas sp. M2, from marine water and isolated various secondary metabolites. Pseudane-VII is a compound isolated from the Pseudoalteromonas sp. M2 metabolite that possesses anti-melanogenic activity. Inflammation is a response of the innate immune system to microbial infections. Macrophages have a critical role in fighting microbial infections and inflammation. Recent studies reported that various compounds derived from natural products can regulate immune responses including inflammation. However, the anti-inflammatory effects and mechanism of pseudane-VII in macrophages are still unknown. In this study, we investigated the anti-inflammatory effects of pseudane-VII. In present study, lipopolysaccharide (LPS)-induced nitric oxide (NO) production was significantly decreased by pseudane-VII treatment at 6 μM. Moreover, pseudane-VII treatment dose-dependently reduced mRNA levels of pro-inflammatory cytokines including inos , cox-2 , il-1β , tnf-α , and il-6 in LPS-stimulated macrophages. Pseudane-VII also diminished iNOS protein levels and IL-1β secretion. In addition, Pseudane-VII elicited anti-inflammatory effects by inhibiting ERK, JNK, p38, and nuclear factor (NF)-κB-p65 phosphorylation. Consistently, pseudane-VII was also shown to inhibit the LPS-stimulated release of IL-1β and expression of iNOS in mice. These results suggest that pseudane-VII exerted anti-inflammatory effects on LPS-stimulated macrophage activation via inhibition of ERK, JNK, p38 MAPK phosphorylation, and pro-inflammatory gene expression. These findings may provide new approaches in the effort to develop anti-inflammatory therapeutics.

  17. In-body tissue-engineered aortic valve (Biovalve type VII) architecture based on 3D printer molding.

    Science.gov (United States)

    Nakayama, Yasuhide; Takewa, Yoshiaki; Sumikura, Hirohito; Yamanami, Masashi; Matsui, Yuichi; Oie, Tomonori; Kishimoto, Yuichiro; Arakawa, Mamoru; Ohmuma, Kentaro; Tajikawa, Tsutomu; Kanda, Keiichi; Tatsumi, Eisuke

    2015-01-01

    In-body tissue architecture--a novel and practical regeneration medicine technology--can be used to prepare a completely autologous heart valve, based on the shape of a mold. In this study, a three-dimensional (3D) printer was used to produce the molds. A 3D printer can easily reproduce the 3D-shape and size of native heart valves within several processing hours. For a tri-leaflet, valved conduit with a sinus of Valsalva (Biovalve type VII), the mold was assembled using two conduit parts and three sinus parts produced by the 3D printer. Biovalves were generated from completely autologous connective tissue, containing collagen and fibroblasts, within 2 months following the subcutaneous embedding of the molds (success rate, 27/30). In vitro evaluation, using a pulsatile circulation circuit, showed excellent valvular function with a durability of at least 10 days. Interposed between two expanded polytetrafluoroethylene grafts, the Biovalves (N = 3) were implanted in goats through an apico-aortic bypass procedure. Postoperative echocardiography showed smooth movement of the leaflets with minimal regurgitation under systemic circulation. After 1 month of implantation, smooth white leaflets were observed with minimal thrombus formation. Functional, autologous, 3D-shaped heart valves with clinical application potential were formed following in-body embedding of specially designed molds that were created within several hours by 3D printer. © 2014 Wiley Periodicals, Inc.

  18. Interpretation of strain measurements on nuclear pressure vessels

    International Nuclear Information System (INIS)

    Andersen, S.I.; Engbaek, P.

    1979-11-01

    Selected results from strain measurements on 4 nuclear pressure vessels are presented and discussed. The measurements were made in several different regions of the vessels: transition zones in vessel heads, flanges and bottom parts, nozzels, internal vessel structure and flange bolts. The results presented are based on data obtained by approximately 700 strain-gauges, and a comprehensive knowledge of the quality obtained by such measurements is established. It is shown that a thorough control procedure before and after the test as well as detailed knowledge of the behaviour of the signal from the individual gauges during the test is necessary. If this is omitted, it can be extremely difficult to distinguish between the real structural behaviour and a malfunctioning of a specific gauge installation. In general, most of the measuring results exhibit a very linear behaviour with a negligible zeroshift. However, deviations from linear behaviour are observed in several cases. This nonlinearity can be explained by friction (flange connections) or by gaps (concentrical nozzles) in certain regions, whereas local plastic deformations during the first pressure loadings of the vessel seem to be the reason in other regions. (author)

  19. TMI-2 Vessel Investigation Project (VIP) Metallurgical Program

    International Nuclear Information System (INIS)

    Diercks, D.R.; Neimark, L.A.

    1990-06-01

    The TMI-2 Vessel Investigation Project (VIP) Metallurgical Program is a part of the international TMI-2 Vessel Investigation Project being conducting jointly by the US Nuclear Regulatory Commission and the Organization for Economic Co-operation and Development (OECD). The overall project consists of three phases, namely (1) recovery of material samples from the lower head of the TMI-2 reactor, (2) examination and analysis of the lower head samples and the preparation and testing of archive material subjected to a similar thermal history, and (3) procurement, examination, and analysis of companion core material located adjacent to or near the lower head material. The specific objectives of the ANL Metallurgical Program, which comprises a major portion of Phase 2, are to prepare metallographic and mechanical test specimen blanks from the TMI-2 lower head material, prepare similar test specimen blanks from suitable archive material subjected to the appropriate thermal processing, determine the mechanical properties of the lower vessel head and archive materials under the conditions of the core-melt accident, and assess the lower head integrity and margin-to-failure during the accident. The ANL work consists of three tasks: (1) archive materials program, (2) fabrication of metallurgical and mechanical test specimens from the TMI-2 pressure vessel samples, and (3) mechanical property characterization of TMI-2 lower pressure vessel head and archive material

  20. AFSC/FMA/Vessel Assessment Logging

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Vessels fishing trawl gear, vessels fishing hook-and-line and pot gear that are also greater than 57.5 feet overall, and shoreside and floating processing facilities...

  1. 2013 EPA Vessels General Permit (VGP)

    Data.gov (United States)

    U.S. Environmental Protection Agency — Information for any vessel that submitted a Notice of Intent (NOI), Notice of Termination (NOT), or annual report under EPA's 2013 Vessel General Permit (VGP)....

  2. Combining endoscopes with PIV and digital holography for the study of vessel model mechanics

    International Nuclear Information System (INIS)

    Arévalo, Laura; Palero, Virginia; Andrés, Nieves; Arroyo, M P; Lobera, Julia

    2015-01-01

    In this work traditional fluid and solid mechanics measurement techniques have been combined with endoscopes for the study of blood vessel models’ mechanical properties. Endoscopes have been used as the imaging part of a high-speed PIV system to obtain the velocity field in a vessel model immersed in a container with a refractive index-matching liquid. In this way, we take advantage of the fact that the endoscope tip can be immersed in liquid. Endoscopes have also been used as the imaging and illuminating part of a digital holographic set-up for wall deformation measurement. The novelty of this work is that only one endoscope was used for illuminating and observing the vessel model, using the endoscope’s own illuminating system as the illumination source. The performance of endoscopes in different vessel models has been tested. The results of flow velocity and wall deformation in the different blood vessel models are presented. (paper)

  3. Dichotomy in Hedgehog Signaling between Human Healthy Vessel and Atherosclerotic Plaques

    NARCIS (Netherlands)

    Queiroz, Karla C. S.; Bijlsma, Maarten F.; Tio, René A.; Zeebregts, Clark J.; Dunaeva, Marina; Ferreira, Carmen V.; Fuhler, Gwenny M.; Kuipers, Ernst J.; Alves, Maria M.; Rezaee, Farhad; Spek, C. Arnold; Peppelenbosch, Maikel P.

    2012-01-01

    The major cause for plaque instability in atherosclerotic disease is neoangiogenic revascularization, but the factors controlling this process remain only partly understood. Hedgehog (HH) is a morphogen with important functions in revascularization, but its function in human healthy vessel biology

  4. 46 CFR 199.610 - Exemptions for vessels in specified services.

    Science.gov (United States)

    2010-10-01

    ... Specified Services Section or paragraph in this part Service Oceans Coastwise Great Lakes Lakes, Bays, and... helpless person can be observed from the navigating bridge; and A(iii) the vessel does not regularly engage...

  5. 46 CFR 11.530 - Endorsements for engineers of uninspected fishing industry vessels.

    Science.gov (United States)

    2010-10-01

    ... applies to endorsements for chief and assistant engineers of all vessels, however propelled, navigating... ocean waters and with horsepower limitations in accordance with the provisions of § 11.503 of this part...

  6. Activation of factor VII bound to tissue factor: a key early step in the tissue factor pathway of blood coagulation.

    OpenAIRE

    Rao, L V; Rapaport, S I

    1988-01-01

    Whether the factor VII/tissue factor complex that forms in tissue factor-dependent blood coagulation must be activated to factor VIIa/tissue factor before it can activate its substrates, factor X and factor IX, has been a difficult question to answer because the substrates, once activated, back-activate factor VII. Our earlier studies suggested that human factor VII/tissue factor cannot activate factor IX. Studies have now been extended to the activation of factor X. Reaction mixtures were ma...

  7. Interstitial Cells of Blood Vessels

    Directory of Open Access Journals (Sweden)

    Vladimír Pucovský

    2010-01-01

    Full Text Available Blood vessels are made up of several distinct cell types. Although it was originally thought that the tunica media of blood vessels was composed of a homogeneous population of fully differentiated smooth muscle cells, more recent data suggest the existence of multiple smooth muscle cell subpopulations in the vascular wall. One of the cell types contributing to this heterogeneity is the novel, irregularly shaped, noncontractile cell with thin processes, termed interstitial cell, found in the tunica media of both veins and arteries. While the principal role of interstitial cells in veins seems to be pacemaking, the role of arterial interstitial cells is less clear. This review summarises the knowledge of the functional and structural properties of vascular interstitial cells accumulated so far, offers hypotheses on their physiological role, and proposes directions for future research.

  8. The Vessel Schedule Recovery Problem

    DEFF Research Database (Denmark)

    Brouer, Berit Dangaard; Plum, Christian Edinger Munk; Vaaben, Bo

    Maritime transportation is the backbone of world trade and is accountable for around 3% of the worlds CO2 emissions. We present the Vessel Schedule Recovery Problem (VSRP) to evaluate a given disruption scenario and to select a recovery action balancing the trade off between increased bunker cons...... consumption and the impact on the remaining network and the customer service level. The model is applied to 4 real cases from Maersk Line. Solutions are comparable or superior to those chosen by operations managers. Cost savings of up to 58% may be achieved.......Maritime transportation is the backbone of world trade and is accountable for around 3% of the worlds CO2 emissions. We present the Vessel Schedule Recovery Problem (VSRP) to evaluate a given disruption scenario and to select a recovery action balancing the trade off between increased bunker...

  9. Nuclear power plant pressure vessels. Inservice inspections

    International Nuclear Information System (INIS)

    1995-01-01

    The requirements for the planning and reporting of inservice inspections of nuclear power plant pressure vessels are presented. The guide specifically applies to inservice inspections of Safety class 1 and 2 nuclear power plant pressure vessels, piping, pumps and valves plus their supports and reactor pressure vessel internals by non- destructive examination methods (NDE). Inservice inspections according to the Pressure Vessel Degree (549/73) are discussed separately in the guide YVL 3.0. (4 refs.)

  10. Expanded Fermilab pressure vessel directory program

    Energy Technology Data Exchange (ETDEWEB)

    Tanner, A.

    1983-01-01

    Several procedures have been written to manage the information pertaining to the vacuum tanks and pressure vessels for which the laboratory is responsible. These procedures have been named TANK1 for the vessels belonging to the Accelerator Division, TANK2 and TANK3 for the vessels belonging to the Research Division and to Technical Support respectively, and TANK4 for the vessels belonging to the Business Division. The operating procedures are otherwise identical in every respect.

  11. Expanded Fermilab pressure vessel directory program

    International Nuclear Information System (INIS)

    Tanner, A.

    1983-01-01

    Several procedures have been written to manage the information pertaining to the vacuum tanks and pressure vessels for which the laboratory is responsible. These procedures have been named TANK1 for the vessels belonging to the Accelerator Division, TANK2 and TANK3 for the vessels belonging to the Research Division and to Technical Support respectively, and TANK4 for the vessels belonging to the Business Division. The operating procedures are otherwise identical in every respect

  12. Materials for high temperature reactor vessels

    International Nuclear Information System (INIS)

    Buenaventura Pouyfaucon, A.

    2004-01-01

    Within the 5th Euraton Framework Programme, a big effort is being made to promote and consolidate the development of the High Temperature Reactor (HTR). Empresarios Agrupados is participating in this project and among others, also forms part of the HTR-M project Materials for HTRs. This paper summarises the work carried out by Empresarios Agrupados regarding the material selection of the HTR Reactor Pressure Vessel (RPV). The possible candidate materials and the most promising ones are discussed. Design aspects such as the RPV sensitive zones and material damage mechanisms are considered. Finally, the applicability of the existing design Codes and Standards for the design of the HTR RPV is also discussed. (Author)

  13. Vacuum vessel for plasma devices

    International Nuclear Information System (INIS)

    Yamada, Masao; Taguchi, Masami.

    1975-01-01

    Object: To permit effective utility of the space in the inner and outer sides of the container wall and also permit repeated assembly for use. Structure: Vacuum vessel wall sections are sealed together by means of welding bellows, and also flange portions formed at the end of the wall sections are coupled together by bolts and are sealed together with a seal ring and a seal cap secured by welding. (Nakamura, S.)

  14. Reactor vessel head permanent shield

    International Nuclear Information System (INIS)

    Hankinson, M.F.; Leduc, R.J.; Richard, J.W.; Malandra, L.J.

    1989-01-01

    A nuclear reactor is described comprising: a nuclear reactor pressure vessel closure head; control rod drive mechanisms (CRDMs) disposed within the closure head so as to project vertically above the closure head; cooling air baffle means surrounding the control rod drive mechanisms for defining cooling air paths relative to the control rod drive mechanisms; means defined within the periphery of the closure head for accommodating fastening means for securing the closure head to its associated pressure vessel; lifting lugs fixedly secured to the closure head for facilitating lifting and lowering movements of the closure head relative to the pressure vessel; lift rods respectively operatively associated with the plurality of lifting lugs for transmitting load forces, developed during the lifting and lowering movements of the closure head, to the lifting lugs; upstanding radiation shield means interposed between the cooling air baffle means and the periphery of the enclosure head of shielding maintenance personnel operatively working upon the closure head fastening means from the effects of radiation which may emanate from the control rod drive mechanisms and the cooling air baffle means; and connecting systems respectively associated with each one of the lifting lugs and each one of the lifting rods for connecting each one of the lifting rods to a respective one of each one of the lifting lugs, and for simultaneously connecting a lower end portion of the upstanding radiation shield means to each one of the respective lifting lugs

  15. Reactor-vessel-sectioning demonstration

    International Nuclear Information System (INIS)

    Lundgren, R.A.

    1981-09-01

    A technical demonstration was successfully completed of simulated reactor vessel sectioning using the combined techniques of air arc gouging and flame cutting. A 4-ft x 3-ft x 9-in. thick sample was fabricated of A36 carbon steel to simulate a reactor vessel wall. A 1/4-in. layer of stainless steel (SS) was tungsten inert gas (TIG)-welded to the carbon steel. Several techniques were considered to section the simulated reactor vessel; air arc gouging was selected to penetrate the stainless steel, and flame cutting was selected to sever the carbon steel. Three sectioning operations were demonstrated. For all three, the operating parameters were the same; but the position of the sample was varied. For the first cut, the sample was placed in a horizontal position, and it was successfully severed from the SS side. For the second cut, the sample was turned over and cut from the carbon steel side. Cutting from the carbon steel side has the advantages of cost reduction

  16. 33 CFR 151.1512 - Vessel safety.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Vessel safety. 151.1512 Section... River § 151.1512 Vessel safety. Nothing in this subpart relieves the master of the responsibility for ensuring the safety and stability of the vessel or the safety of the crew and passengers, or any other...

  17. Reactor vessel supported by flexure member

    International Nuclear Information System (INIS)

    Crawford, J.D.; Pankow, B.

    1975-01-01

    A description is given of a reactor pressure vessel which is provided with vertical support means in the form of circumferentially spaced columns upon which the vessel is mounted. The columns are adapted to undergo flexure in order to accommodate the thermally induced displacements experienced by the vessel during operational transients

  18. 19 CFR 4.97 - Salvage vessels.

    Science.gov (United States)

    2010-04-01

    ... United States and Great Britain ‘concerning reciprocal rights for United States and Canada in the... meaning of this statute. (e) A Mexican vessel may engage in a salvage operation on a Mexican vessel in any territorial waters of the United States in which Mexican vessels are permitted to conduct such operations by...

  19. Model tests for prestressed concrete pressure vessels

    International Nuclear Information System (INIS)

    Stoever, R.

    1975-01-01

    Investigations with models of reactor pressure vessels are used to check results of three dimensional calculation methods and to predict the behaviour of the prototype. Model tests with 1:50 elastic pressure vessel models and with a 1:5 prestressed concrete pressure vessel are described and experimental results are presented. (orig.) [de

  20. 50 CFR 648.4 - Vessel permits.

    Science.gov (United States)

    2010-10-01

    ... carrying passengers for hire. (8) Atlantic bluefish vessels. (i) Commercial. Any vessel of the United... lands Atlantic bluefish in or from the EEZ in excess of the recreational possession limit specified at § 648.164 must have been issued and carry on board a valid commercial bluefish vessel permit. (ii) Party...

  1. 46 CFR 42.09-5 - All vessels-division into types.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false All vessels-division into types. 42.09-5 Section 42.09-5... BY SEA Load Line Assignments and Surveys-General Requirements § 42.09-5 All vessels—division into types. (a) For the purposes of this part, each vessel to which this part applies is either a Type “A” or...

  2. Current meter components and other data from XCP casts from VARIOUS SMALL VESSELS and other platforms from the North Atlantic Ocean as part of the OCEAN DUMPING and other projects from 01 December 1990 to 01 June 1991 (NODC Accession 9300076)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current meter components and other data were collected from XCP casts from VARIOUS SMALL VESSELS and other platforms in the North Atlantic Ocean. Data were collected...

  3. Nuclear reactor installation with outer shell enclosing a primary pressure vessel

    International Nuclear Information System (INIS)

    1975-01-01

    The high temperature nuclear reactor installation described includes a fluid cooled nuclear heat source, a primary pressure vessel and outer shell around the primary pressure vessel and acting as a protection for it against outside projectiles. A floor is provided internally dividing the outside shell into two upper and lower sections and an inside wall dividing the lower section into one part containing the primary pressure vessel and a second part, both made pressure tight with respect to each other and with the outside shell and forming with the latter a secondary means of containment [fr

  4. Welding distortion control in double walled KSTAR vacuum vessel fabrication

    International Nuclear Information System (INIS)

    Oh, D. W.; Lee, G. T.; Kim, H. K.; Yang, H. L.; Bak, J. S.

    2004-01-01

    The KSTAR(Korea Superconducting Tokamak Advanced Research) vacuum vessel is designed to be a double walled structure made of 12mm thick 316LN stainless steel with a D shaped cross-section about 4 m height. Vacuum vessel was pre-fabricated in two parts, 180 degree and 157.5 degree sectors in toroidal direction to meet the transportation purpose. These two parts have to be welded on site with ±2mm allowable fabrication tolerances. 1/3 scaled mock-up model was used to estimate the welding distortion and to ensure the weld quality of vacuum vessel. Gas Tungsten Arc Welding(GTAW), which has been approved by procedure qualification test, was used during mock-up test and vacuum vessel site fabrication. Welding distortion could be managed by allowing for distortion in opposite direction, by applying high restraint using lots of strong backs, by controlling the welding heat input with symmetrical welding sequence. The integrity of the site welding joint was assured by radiographic test, ultrasonic test and leak test with helium detecting method

  5. Integrating Multiple Autonomous Underwater Vessels, Surface Vessels and Aircraft into Oceanographic Research Vessel Operations

    Science.gov (United States)

    McGillivary, P. A.; Borges de Sousa, J.; Martins, R.; Rajan, K.

    2012-12-01

    Autonomous platforms are increasingly used as components of Integrated Ocean Observing Systems and oceanographic research cruises. Systems deployed can include gliders or propeller-driven autonomous underwater vessels (AUVs), autonomous surface vessels (ASVs), and unmanned aircraft systems (UAS). Prior field campaigns have demonstrated successful communication, sensor data fusion and visualization for studies using gliders and AUVs. However, additional requirements exist for incorporating ASVs and UASs into ship operations. For these systems to be optimally integrated into research vessel data management and operational planning systems involves addressing three key issues: real-time field data availability, platform coordination, and data archiving for later analysis. A fleet of AUVs, ASVs and UAS deployed from a research vessel is best operated as a system integrated with the ship, provided communications among them can be sustained. For this purpose, Disruptive Tolerant Networking (DTN) software protocols for operation in communication-challenged environments help ensure reliable high-bandwidth communications. Additionally, system components need to have considerable onboard autonomy, namely adaptive sampling capabilities using their own onboard sensor data stream analysis. We discuss Oceanographic Decision Support System (ODSS) software currently used for situational awareness and planning onshore, and in the near future event detection and response will be coordinated among multiple vehicles. Results from recent field studies from oceanographic research vessels using AUVs, ASVs and UAS, including the Rapid Environmental Picture (REP-12) cruise, are presented describing methods and results for use of multi-vehicle communication and deliberative control networks, adaptive sampling with single and multiple platforms, issues relating to data management and archiving, and finally challenges that remain in addressing these technological issues. Significantly, the

  6. Process for producing curved surface of membrane rings for large containers, particulary for prestressed concrete pressure vessels of nuclear reactors

    International Nuclear Information System (INIS)

    Kumpf, H.

    1977-01-01

    Membrane rings for large pressure vessels, particularly for prestressed-concrete pressure vessels, often have curved surfaces. The invention describes a process of producing these at site, which is particularly advantageous as the forming and installation of the vessel component coincide. According to the invention, the originally flat membrane ring is set in a predetermined position, is then pressed in sections by a forming tool (with a preformed support ring as opposite tool), and shaped. After this, the shaped parts are welded to the ring-shaped wall parts of the large vessel. The manufacture of single and double membrane rings arrangements is described. (HP) [de

  7. Commissioning result of the KSTAR in-vessel cryo-pump

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Y. B.; Lee, H. J.; Park, Y.M. [National Fusion Research Institute, Daejeon (Korea, Republic of); and others

    2013-12-15

    KSTAR in-vessel cryo-pump has been installed in the vacuum vessel top and bottom side with up-down symmetry for the better plasma density control in the D-shape H-mode. The cryogenic helium lines of the in-vessel cryo-pump are located at the vertical positions from the vacuum vessel torus center 2,000 mm. The inductive electrical potential has been optimized to reduce risk of electrical breakdown during plasma disruption. In-vessel cryo-pump consists of three parts of coaxial circular shape components; cryo-panel, thermal shield and particle shield. The cryo-panel is cooled down to below 4.5 K. The cryo-panel and thermal shields were made by Inconel 625 tube for higher mechanical strength. The thermal shields and their cooling tubes were annealed in air environment to improve the thermal radiation emissivity on the surface. Surface of cryo-panel was electro-polished to minimize the thermal radiation heat load. The in-vessel cryo-pump was pre-assembled on a test bed in 180 degree segment base. The leak test was carried out after the thermal shock between room temperature to LN2 one before installing them into vacuum vessel. Two segments were welded together in the vacuum vessel and final leak test was performed after the thermal shock. Commissioning of the in-vessel cryo-pump was carried out using a temporary liquid helium supply system.

  8. Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men

    DEFF Research Database (Denmark)

    Tholstrup, T.; Miller, G.J.; Bysted, Anette

    2003-01-01

    Background: Hypertriglyceridemia may represent a procoagulant state involving disturbances to the hemostatic system. Plasminogen activator inhibitor type 1 (PAI-1) is increased in the presence of hypertriglyceridemia. Free fatty acids (FFAs) in plasma may promote factor VII (FVII) activation...

  9. Department of Neurosurgery, Seth Gordhandas Sunderdas Medical College and King Edward VII Memorial (K.E.M.) Hospital, Mumbai.

    Science.gov (United States)

    Pandya, Sunil; Goel, Atul

    2017-01-01

    Seth Gordhandas Sunderdas Medical College and King Edward VII Memorial (K.E.M.) Hospital, Mumbai were inaugurated in 1925. This article traces its illustrious history and of the eminent neurosurgeons who shaped its destiny.

  10. Flaw distribution development from vessel ISI data

    International Nuclear Information System (INIS)

    Foulds, J.R.; Kennedy, E.L.; Basin, S.L.; Rosinski, S.T.

    1991-01-01

    Previous attempts to develop flaw distributions for use in the structural integrity evaluation of pressurized water reactor (PWR) vessels have aimed at the estimation of a ''generic'' distribution applicable to all vessels. In contrast, this paper describes the analysis of vessel-specific in-service inspection (ISI) data for the development of a flaw distribution reliably representative of the condition of the particular vessel inspected. The application of the methodology may be extended to other vessels, but has been primarily developed for PWR reactor vessels. For this study, the flaw data analyzed included data obtained from three recently performed PWR vessel ISIs and from laboratory inspection of selected weldment sections of the Midland reactor vessel. The variability in both the character of the reviewed data (size range of flaws, number of flaws) and the UT (ultrasonic test) inspection system performance identified a need for analyzing the inspection results on a vessel-, or data set-specific basis. For this purpose, traditional histogram-based methods were inadequate, and a new methodology that can accept a very small number of flaws (typical of vessel-specific ISI results) and that includes consideration of inspection system flaw detection reliability, flaw sizing accuracy and flaw detection threshold, was developed. Results of the application of the methodology to each of the four PWR reactor vessel cases studied are presented and discussed

  11. Factor VII-activating protease in patients with acute deep venous thrombosis

    DEFF Research Database (Denmark)

    Sidelmann, Johannes J; Vitzthum, Frank; Funding, Eva

    2008-01-01

    Factor VII-activating protease (FSAP) is involved in haemostasis and inflammation. FSAP cleaves single chain urokinase-type plasminogen activator (scu-PA). The 1601GA genotype of the 1601G/A polymorphism in the FSAP gene leads to the expression of a FSAP variant with reduced ability to activate scu......-PA, without affecting the ability to activate coagulation Factor VII (FVII). Previous studies have investigated the association of the 1601GA genotype with incidence and progression of carotid stenosis and deep venous thrombosis (DVT). The present study is the first to evaluate the potential association...... between the FSAP phenotype and DVT. We studied the association between the 1601G/A polymorphism, FSAP activity, FSAP antigen, Factor VIIa (FVIIa), prothrombin fragment 1+2 (F1+2), and C-reactive protein (CRP) in plasmas of 170 patients suspected for DVT. FSAP genotypes were equally distributed in patients...

  12. Sobre el envío de tropas de la Legio VII Gemina al limes africano

    Directory of Open Access Journals (Sweden)

    Juan José PALAO VICENTE

    2010-02-01

    Full Text Available RESUMEN: Las relaciones entre Hispania y Africa en época romana fueron corrientes en todos los campos, incluyendo el militar. Este artículo intenta analizar la presencia en territorio africano de tropas de la Legio VII Gemina, tratando de conocer cuáles fueron los verdaderos motivos de dicha estancia. El estudio del material amplía la visión tradicional de las posibles funciones allí desempeñadas por estos destacamentos, que posiblemente abarcaron aspectos administrativos y logísticos.ABSTRACT: The relationship between Hispania and Africa in the Roman world were very strong in alls fields incluiding the military, too. This paper purposes to analize the presence of legio VII Gemina's troops in African territories, attempting to know the true reasons of this presence.The study of material presents a new vision about the mission of those troops, which undertake possibly administratives and logistics works.

  13. Nuclear energy and astrophysics applications of ENDF/B-VII.1 evaluated nuclear library

    International Nuclear Information System (INIS)

    Pritychenko, B.

    2012-01-01

    Recently released ENDF/B-VII.1 evaluated nuclear library contains the most up-to-date evaluated neutron cross section and covariance data. These data provide new opportunities for nuclear science and astrophysics application development. The improvements in neutron cross section evaluations and more extensive utilization of covariance files, by the Cross Section Evaluation Working Group (CSEWG) collaboration, allowed users to produce neutron thermal cross sections, Westcott factors, resonance integrals, Maxwellian-averaged cross sections and astrophysical reaction rates, and provide additional insights on the currently available neutron-induced reaction data. Nuclear reaction calculations using the ENDF/B-VII.1 library and current computer technologies will be discussed and new results will be presented

  14. Uso de fator VII recombinante ativado para tratamento e profilaxia de grandes sangramentos Use of recombinant activated factor VII for treatment and prophylaxis of major bleeding

    Directory of Open Access Journals (Sweden)

    Flávio Augusto Henriques Vince

    2009-09-01

    Full Text Available INTRODUÇÃO: O fator VII recombinante ativado (rFVIIa é uma proteína produzida por engenharia genética, cuja estrutura é muito semelhante à do fator VII intrínseco ativado (FVII. Sua ação se baseia no conhecimento do mecanismo de coagulação in vivo agindo na ativação direta do fator X resultando em formação independente de trombina no local da lesão e contribuindo dessa forma para formação de coágulo estável de fibrina sem a ação dos fatores VIII e IX. MÉTODOS: Foi realizada ampla revisão da literatura com o objetivo de determinar os achados recentes relacionados ao uso de fator VII recombinante ativado em pacientes com sangramento severo. RESULTADOS: Constatou-se que o uso de rFVIIa foi iniciado na década de 80 para profilaxia e tratamento de sangramento em pacientes com antecedente de hemofilia A ou B com inibidores de fator VIII e IX, deficiência de fator VII e trombastenia de Glanzmann refratários à reposição plaquetária. Em 1999 seu uso foi ampliado para outras situações clínicas e dessa forma, começaram a ser publicados diversos trabalhos mostrando a eficácia do rFVIIa como agente pró-hemostático em paciente com outras coagulopatias ou pacientes previamente hígidos com história de sangramento agudo de grande monta. Trauma é a principal causa de mortalidade no mundo sendo sangramento incontrolado o principal desafio no atendimento a estes pacientes. É comum a associação de trauma com coagulopatia, necessitando em algumas situações de terapia específica para o tratamento da mesma. Neste momento a terapia adjuvante com rFVIIa deve ser considerada. Outras causas comuns de sangramento são as operações cardíacas e ginecológicas/ obstétricas e doenças envolvendo o fígado. A coagulopatia nesses casos ocorre por deficiência dos fatores dependentes de vitamina K, sendo o FVII o com menor meia-vida. CONCLUSÃO: O uso de rFVIIa tem sido sugerido como opção terapêutica promissora para esses

  15. Advanced in-vessel retention design for next generation risk management

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Kune Y.; Hwang, Il Soon [Seoul National University, Seoul (Korea, Republic of)

    1997-12-31

    In the TMI-2 accident, approximately twenty (20) tons of molten core material drained into the lower plenum. Early advanced light water reactor (LWR) designs assumed a lower head failure and incorporated various measures for ex-vessel accident mitigation. However,one of the major findings from the TMI-2 Vessel Investigation Project was that one part of the reactor lower head wall estimated to have attained a temperature of 1100 deg C for about 30 minutes has seemingly experienced a comparatively rapid cooldown with no major threat to the vessel integrity. In this regard, recent empirical and analytical studies have shifted interests to such in-vessel retention designs or strategies as reactor cavity flooding, in-vessel flooding and engineered gap cooling of the vessel. Accurate thermohydrodynamic and creep deformation modeling and rupture prediction are the key to the success in developing practically useful in-vessel accident/risk management strategies. As an advanced in-vessel design concept, this work presents the COrium Attack Syndrome Immunization Structures (COASIS) that are being developed as prospective in-vessel retention devices for a next-generation LWR in concert with existing ex-vessel management measures. Both the engineered gap structures in-vessel (COASISI) and ex-vessel (COASISO) are demonstrated to maintain effective heat transfer geometry during molten core debris attack when applied to the Korean Standard Nuclear Power Plant (KSNPP) reactor. The likelihood of lower head creep rupture during a severe accident is found to be significantly suppressed by the COASIS options. 15 refs., 5 figs., 1 tab. (Author)

  16. Advanced in-vessel retention design for next generation risk management

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Kune Y; Hwang, Il Soon [Seoul National University, Seoul (Korea, Republic of)

    1998-12-31

    In the TMI-2 accident, approximately twenty (20) tons of molten core material drained into the lower plenum. Early advanced light water reactor (LWR) designs assumed a lower head failure and incorporated various measures for ex-vessel accident mitigation. However,one of the major findings from the TMI-2 Vessel Investigation Project was that one part of the reactor lower head wall estimated to have attained a temperature of 1100 deg C for about 30 minutes has seemingly experienced a comparatively rapid cooldown with no major threat to the vessel integrity. In this regard, recent empirical and analytical studies have shifted interests to such in-vessel retention designs or strategies as reactor cavity flooding, in-vessel flooding and engineered gap cooling of the vessel. Accurate thermohydrodynamic and creep deformation modeling and rupture prediction are the key to the success in developing practically useful in-vessel accident/risk management strategies. As an advanced in-vessel design concept, this work presents the COrium Attack Syndrome Immunization Structures (COASIS) that are being developed as prospective in-vessel retention devices for a next-generation LWR in concert with existing ex-vessel management measures. Both the engineered gap structures in-vessel (COASISI) and ex-vessel (COASISO) are demonstrated to maintain effective heat transfer geometry during molten core debris attack when applied to the Korean Standard Nuclear Power Plant (KSNPP) reactor. The likelihood of lower head creep rupture during a severe accident is found to be significantly suppressed by the COASIS options. 15 refs., 5 figs., 1 tab. (Author)

  17. Monocytes can be induced by lipopolysaccharide-triggered T lymphocytes to express functional factor VII/VIIa protease activity

    OpenAIRE

    1984-01-01

    In the present study we demonstrate that human monocytes can be induced by the model stimulus, lipopolysaccharide (LPS), to produce and assemble on their surface functional Factor VII/VIIa. This protease was not induced in relatively purified monocytes alone following exposure to LPS; but was induced in the presence of Leu-3a positive helper/inducer T cells. The Factor VII/VIIa protease activity represented 35-40% of the potential initiating activity for the extrinsic coagulation pathway and ...

  18. PENGARUH KEMANDIRIAN BELAJAR DAN PENGGUNAAN UANG SAKU TERHADAP PRESTASI BELAJAR KOMPETENSI DASAR EKONOMI KELAS VII DAN VIII

    OpenAIRE

    Apri Dwi Astuti

    2012-01-01

    Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah ...

  19. 29 CFR 1620.27 - Relationship to the Equal Pay Act of title VII of the Civil Rights Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Relationship to the Equal Pay Act of title VII of the Civil... OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.27 Relationship to the Equal Pay Act of title VII of the Civil... equal pay under the Equal Pay Act has no relationship to whether the employee is in the lower paying job...

  20. Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy.

    Science.gov (United States)

    Duanmu, J; Cheng, J; Xu, J; Booth, C J; Hu, Z

    2011-04-26

    The purpose of this study was to test a novel, dual tumour vascular endothelial cell (VEC)- and tumour cell-targeting factor VII-targeted Sn(IV) chlorin e6 photodynamic therapy (fVII-tPDT) by targeting a receptor tissue factor (TF) as an alternative treatment for chemoresistant breast cancer using a multidrug resistant (MDR) breast cancer line MCF-7/MDR. The TF expression by the MCF-7/MDR breast cancer cells and tumour VECs in MCF-7/MDR tumours from mice was determined separately by flow cytometry and immunohistochemistry using anti-human or anti-murine TF antibodies. The efficacy of fVII-tPDT was tested in vitro and in vivo and was compared with non-targeted PDT for treatment of chemoresistant breast cancer. The in vitro efficacy was determined by a non-clonogenic assay using crystal violet staining for monolayers, and apoptosis and necrosis were assayed to elucidate the underlying mechanisms. The in vivo efficacy of fVII-tPDT was determined in a nude mouse model of subcutaneous MCF-7/MDR tumour xenograft by measuring tumour volume. To our knowledge, this is the first presentation showing that TF was expressed on tumour VECs in chemoresistant breast tumours from mice. The in vitro efficacy of fVII-tPDT was 12-fold stronger than that of ntPDT for MCF-7/MDR cancer cells, and the mechanism of action involved induction of apoptosis and necrosis. Moreover, fVII-tPDT was effective and safe for the treatment of chemoresistant breast tumours in the nude mouse model. We conclude that fVII-tPDT is effective and safe for the treatment of chemoresistant breast cancer, presumably by simultaneously targeting both the tumour neovasculature and chemoresistant cancer cells. Thus, this dual-targeting fVII-tPDT could also have therapeutic potential for the treatment of other chemoresistant cancers.

  1. Simplified methods applied to the complete thermal and mechanical behaviour of a pressure vessel during a severe accident

    International Nuclear Information System (INIS)

    Dupas, P.

    1996-01-01

    EDF has developed a software package of simplified methods (proprietary ones from literature) in order to study the thermal and mechanical behaviour of a PWR pressure vessel during a severe accident involving a corium localization in the vessel lower head. Using a part of this package, we can evaluate for instance successively: the heat flux at the inner surface of the vessel (conductive or convective pool of corium); the thermal exchange coefficient between the vessel and the outside (dry pit or flooded pit, watertight thermal insulation or not); the complete thermal evolution of the vessel (temperature profile, melting); the possible global plastic failure of the vessel; the creep behaviour in the vessel. These simplified methods are low cost alternative to finite element calculations which are yet used to validate the previous methods, waiting for experimental results to come. (authors)

  2. Simplified methods to the complete thermal and mechanical behavior of a pressure vessel during a severe accident

    International Nuclear Information System (INIS)

    Dupas, P.; Schneiter, J.R.

    1996-01-01

    EDF has developed a software package of simplified methods (proprietary ones or from literature) in order to study the thermal and mechanical behavior of a PWR pressure vessel during a severe accident involving a corium localization in the vessel lower head. Using a part of this package, the authors can evaluate for instance successively: the heat flux at the inner surface of the vessel (conductive or convective pool of corium); the thermal exchange coefficient between the vessel and the outside (dry pit or flooded pit, watertight thermal insulation or not); the complete thermal evolution of the vessel (temperature profile, melting); the possible global plastic failure of the vessel; the creep behavior in the thickness of the vessel. These simplified methods are a cost effective alternative to finite element calculations which are yet used to validate the previous methods, waiting for experimental results to come

  3. PENGEMBANGAN BAHAN AJAR MEMBACA PEMAHAMAN BERDASARKAN STRATEGI PLAN (PREDICT, LOCATE, ADD, NOTE) UNTUK SISWA KELAS VII

    OpenAIRE

    Sudiati Sudiati; Nurhidayah Nurhidayah

    2017-01-01

    Abstract This study aims to produce reading comprehension learning materials based on the PLAN strategy and to find out the appropriateness for Grade VII students. This was a design and development study. The stages were taken from those of Borg and Gall. The data were qualitative and quantitative in nature. The data trustworthiness was assessed in terms of credibility, transferability, dependability, and confirmability. The research instruments were an interview guide and ...

  4. Synthesis and characterization of (18)F-labeled active site inhibited factor VII (ASIS).

    Science.gov (United States)

    Erlandsson, Maria; Nielsen, Carsten H; Jeppesen, Troels E; Kristensen, Jesper B; Petersen, Lars C; Madsen, Jacob; Kjaer, Andreas

    2015-05-15

    Activated factor VII blocked in the active site with Phe-Phe-Arg-chloromethyl ketone (active site inhibited factor VII (ASIS)) is a 50-kDa protein that binds with high affinity to its receptor, tissue factor (TF). TF is a transmembrane glycoprotein that plays an important role in, for example, thrombosis, metastasis, tumor growth, and tumor angiogenesis. The aim of this study was to develop an (18)F-labeled ASIS derivative to assess TF expression in tumors. Active site inhibited factor VII was labeled using N-succinimidyl-4-[(18)F]fluorobenzoate, and the [(18)F]ASIS was purified on a PD-10 desalting column. The radiochemical yield was 25 ± 6%, the radiochemical purity was >97%, and the pseudospecific radioactivity was 35 ± 9 GBq/µmol. The binding efficacy was evaluated in pull-down experiments, which monitored the binding of unlabeled ASIS and [(18)F]ASIS to TF and to a specific anti-factor VII antibody (F1A2-mAb). No significant difference in binding efficacy between [(18)F]ASIS and ASIS could be detected. Furthermore, [(18)F]ASIS was relatively stable in vitro and in vivo in mice. In conclusion, [(18)F]ASIS has for the first time been successfully synthesized as a possible positron emission tomography tracer to image TF expression levels. In vivo positron emission tomography studies to evaluate the full potential of [(18)F]ASIS are in progress. Copyright © 2015 John Wiley & Sons, Ltd.

  5. Redox reactions of Tc{sup VII} with magnetite and mackinawite. Solving an old enigma

    Energy Technology Data Exchange (ETDEWEB)

    Yalcintas, E.; Gaona, X.; Altmeier, M. [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany). Inst. for Nuclear Waste Disposal; Scheinost, Andreas C. [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Molecular Structures

    2017-06-01

    While the reduction of heptavalent technetium, Tc(VII), by magnetite and mackinawite under anoxic conditions is well known, the identification of the resulting Tc(IV) species shows substantial disagreement between different studies. Here we use a systematic variation of initial Tc concentration, loading and pH to decipher the Tc species by EXAFS spectroscopy and to shine light on their formation pathways.

  6. Elmo Bumpy Torus proof of principle, Phase II: Title 1 report. Volume VII. Cryogenic system

    International Nuclear Information System (INIS)

    Poteat, T.J.

    1982-01-01

    This document, Volume VII EBT-P Cryogenic System Title I Design Report, describes the system that resulted from the Title I Preliminary Design effort. It is a self-contained document that can be read apart from the other Volumes comprising the EBT-P Title I Report. This document is a contract deliverable item and provides the detail necessary to support the Cryogenic System design contained in the EBT-P Baseline Design Data Book

  7. Desain Pembelajaran Materi Belah Ketupat Menggunakan Kain Jumputan Palembang untuk Siswa Kelas VII

    Directory of Open Access Journals (Sweden)

    Fauziyah Fauziyah

    2016-06-01

    Full Text Available Desain pembelajaran materi belah ketupat menggunakan kain Jumputan Palembang untuk siswa kelas VII. Penelitian ini bertujuan untuk melihat bagaimana penggunaan kain Jumputan Palembang dalam membangun pemahaman siswa mengenai belah ketupat. Siswa akan membandingkan luas daerah dua buah kain Jumputan, merancang dan membuat belah ketupat kemudian menggunting serta menyusunnya kembali menjadi suatu bentuk baru, menentukan luas daerah belah ketupat, membandingkan keliling dua buah kain Jumputan dan menentukan keliling belah ketupat. Subjek penelitian ini adalah 30 siswa kelas VII SMP Pusri Palembang. Penelitian ini menggunakan design research yang terdiri dari tiga tahap : preparing for the experiment, experiment in the classroom (pilot experiment dan  teaching experiment, dan retrospective analysis. Pada tahap preparing for the experiment, beberapa aktifitas dibuat menggunakan pendekatan Pendidikan Matematika Realistik Indonesia (PMRI. Hasil dari penelitian menunjukkan kain Jumputan Palembang dapat digunakan sebagai starting point dalam pembelajaran belah ketupat untuk siswa kelas VII SMP.The design learning rhombus using kain Jumputan Palembang for VII grade students. This research aims to investigate how to use Kain Jumputan Palembang to build student’s understanding on rhombus. Students were required to comparing the area of two cloths, designing and making rhombus then reshaping to new shapes, determining the area of rhombus, comparing the perimeter of two cloths and determining the perimeter of rhombus. Subjects were 30 first grade students of SMP Pusri Palembang. The study used a design research method consisting of three stages : preparing for the experiment, experiment in the classroom (pilot experiment and teaching experiment, and retrospective analysis. During the preparing for the experiment stage, instructional activities was designing utilizing of Indonesian Realistic Mathematics Education (PMRI approach. The result of experiments

  8. Release of the ENDF/B-VII.1 Evaluated Nuclear Data File

    Energy Technology Data Exchange (ETDEWEB)

    Brown, David

    2012-06-30

    The Cross Section Evaluation Working Group (CSEWG) released the ENDF/B-VII.1 library on December 22, 2011. The ENDF/B-VII.1 library is CSEWG's latest recommended evaluated nuclear data file for use in nuclear science and technology applications, and incorporates advances made in the five years since the release of ENDF/B-VII.0, including: many new evaluation in the neutron sublibrary (423 in all and over 190 of these contain covariances), new fission product yields and a greatly improved decay data sublibrary. This summary barely touches on the five years worth of advances present in the ENDF/B-VII.1 library. We expect that these changes will lead to improved integral performance in reactors and other applications. Furthermore, the expansion of covariance data in this release will allow for better uncertainty quantification, reducing design margins and costs. The ENDF library is an ongoing and evolving effort. Currently, the ENDF data community embarking on several parallel efforts to improve library management: (1) The adoption of a continuous integration system to provide evaluators 'instant' feedback on the quality of their evaluations and to provide data users with working 'beta' quality libraries in between major releases. (2) The transition to new hierarchical data format - the Generalized Nuclear Data (GND) format. We expect GND to enable new kinds of evaluated data which cannot be accommodated in the legacy ENDF format. (3) The development of data assimilation and uncertainty propagation techniques to enable the consistent use of integral experimental data in the evaluation process.

  9. Primo vessel inside a lymph vessel emerging from a cancer tissue.

    Science.gov (United States)

    Lee, Sungwoo; Ryu, Yeonhee; Cha, Jinmyung; Lee, Jin-Kyu; Soh, Kwang-Sup; Kim, Sungchul; Lim, Jaekwan

    2012-10-01

    Primo vessels were observed inside the lymph vessels near the caudal vena cava of a rabbit and a rat and in the thoracic lymph duct of a mouse. In the current work we found a primo vessel inside the lymph vessel that came out from the tumor tissue of a mouse. A cancer model of a nude mouse was made with human lung cancer cell line NCI-H460. We injected fluorescent nanoparticles into the xenografted tumor tissue and studied their flow in blood, lymph, and primo vessels. Fluorescent nanoparticles flowed through the blood vessels quickly in few minutes, and but slowly in the lymph vessels. The bright fluorescent signals of nanoparticles disappeared within one hour in the blood vessels but remained much longer up to several hours in the case of lymph vessels. We found an exceptional case of lymph vessels that remained bright with fluorescence up to 24 hours. After detailed examination we found that the bright fluorescence was due to a putative primo vessel inside the lymph vessel. This rare observation is consistent with Bong-Han Kim's claim on the presence of a primo vascular system in lymph vessels. It provides a significant suggestion on the cancer metastasis through primo vessels and lymph vessels. Copyright © 2012. Published by Elsevier B.V.

  10. What is cerebral small vessel disease?

    International Nuclear Information System (INIS)

    Onodera, Osamu

    2011-01-01

    An accumulating amount of evidence suggests that the white matter hyperintensities on T 2 weighted brain magnetic resonance imaging predict an increased risk of dementia and gait disturbance. This state has been proposed as cerebral small vessel disease, including leukoaraiosis, Binswanger's disease, lacunar stroke and cerebral microbleeds. However, the concept of cerebral small vessel disease is still obscure. To understand the cerebral small vessel disease, the precise structure and function of cerebral small vessels must be clarified. Cerebral small vessels include several different arteries which have different anatomical structures and functions. Important functions of the cerebral small vessels are blood-brain barrier and perivasucular drainage of interstitial fluid from the brain parenchyma. Cerebral capillaries and glial endfeet, take an important role for these functions. However, the previous pathological investigations on cerebral small vessels have focused on larger arteries than capillaries. Therefore little is known about the pathology of capillaries in small vessel disease. The recent discoveries of genes which cause the cerebral small vessel disease indicate that the cerebral small vessel diseases are caused by a distinct molecular mechanism. One of the pathological findings in hereditary cerebral small vessel disease is the loss of smooth muscle cells, which is an also well-recognized finding in sporadic cerebral small vessel disease. Since pericytes have similar character with the smooth muscle cells, the pericytes should be investigated in these disorders. In addition, the loss of smooth muscle cells may result in dysfunction of drainage of interstitial fluid from capillaries. The precise correlation between the loss of smooth muscle cells and white matter disease is still unknown. However, the function that is specific to cerebral small vessel may be associated with the pathogenesis of cerebral small vessel disease. (author)

  11. 46 CFR 4.03-40 - Public vessels.

    Science.gov (United States)

    2010-10-01

    ... INVESTIGATIONS Definitions § 4.03-40 Public vessels. Public vessel means a vessel that— (a) Is owned, or demise... Department (except a vessel operated by the Coast Guard or Saint Lawrence Seaway Development Corporation...

  12. Progress of ITER vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Ioki, K., E-mail: Kimihiro.Ioki@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Bayon, A. [F4E, c/ Josep Pla, No. 2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Kim, B.C. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Kuzmin, E. [NTC “Sintez”, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Le Barbier, R.; Martinez, J.-M. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Pathak, H. [ITER-India, A-29, GIDC Electronic Estate, Sector 25, Gandhinagar 382025 (India); Preble, J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Sa, J.W. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Terasawa, A.; Utin, Yu. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); and others

    2013-10-15

    Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure.

  13. Progress of ITER vacuum vessel

    International Nuclear Information System (INIS)

    Ioki, K.; Bayon, A.; Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B.; Kim, B.C.; Kuzmin, E.; Le Barbier, R.; Martinez, J.-M.; Pathak, H.; Preble, J.; Sa, J.W.; Terasawa, A.; Utin, Yu.

    2013-01-01

    Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure

  14. Effect of N-acetylcysteine on the accuracy of the prothrombin time assay of plasma coagulation factor II+VII+X activity in subjects infused with the drug. Influence of time and temperature.

    Science.gov (United States)

    Thorsen, Sixtus; Teisner, Ane; Jensen, Søren Astrup; Philips, Malou; Dalhoff, Kim; Bendtsen, Flemming

    2009-01-01

    The prothrombin time (PT) assay of factor II+VII+X activity is an important predictor of liver damage in paracetamol poisoned patients. It complicates interpretation of results that the antidote, acetylcysteine (NAC) depresses this activity. The aim was to investigate if NAC influences the accuracy of the plasma PT assay. The accuracy of Nycotest PT was studied using plasma added NAC in vitro and plasma from subjects infused with NAC. The latter results were compared with those obtained by analysis of PT by CoaguChek S. Therapeutic NAC concentrations added to plasma in vitro decreased factor II+VII+X activity at 37 degrees C in a time-dependent manner. This effect was quenched at temperatures depression of factor II+VII+X activity in plasma from subjects infused with NAC during the first 3h of infusion indicating that it contained reactive NAC. The risk that this NAC interfered with the accuracy of the PT assay was considered minimal with samples stored below 24 degrees C. This was supported by similarity of results obtained by analysis of appropriately stored plasma and simultaneously drawn blood by CoaguChek S. Residual reactive NAC does not interfere with the accuracy of the PT assay of plasma stored below 24 degrees C, but NAC-induced loss in activity at 37 degrees C may be partly recovered during subsequent storage below 24 degrees C.

  15. Immobilization of 99-Technetium (VII) by Fe(II)-Goethite and Limited Reoxidation

    Energy Technology Data Exchange (ETDEWEB)

    W Um; H Chang; J Icenhower; W Lukens; R Serne; N Qafoku; J Westsik Jr.; E Buck; S Smith

    2011-12-31

    During the nuclear waste vitrification process volatilized {sup 99}Tc will be trapped by melter off-gas scrubbers and then washed out into caustic solutions, and plans are currently being contemplated for the disposal of such secondary waste. Solutions containing pertechnetate [{sup 99}Tc(VII)O{sub 4}{sup -}] were mixed with precipitating goethite and dissolved Fe(II) to determine if an iron (oxy)hydroxide-based waste form can reduce Tc(VII) and isolate Tc(IV) from oxygen. The results of these experiments demonstrate that Fe(II) with goethite efficiently catalyzes the reduction of technetium in deionized water and complex solutions that mimic the chemical composition of caustic waste scrubber media. Identification of the phases, goethite + magnetite, was performed using XRD, SEM and TEM methods. Analyses of the Tc-bearing solid products by XAFS indicate that all of the Tc(VII) was reduced to Tc(IV) and that the latter is incorporated into goethite or magnetite as octahedral Tc(IV). Batch dissolution experiments, conducted under ambient oxidizing conditions for more than 180 days, demonstrated a very limited release of Tc to solution (2-7 {micro}g Tc/g solid). Incorporation of Tc(IV) into the goethite lattice thus provides significant advantages for limiting reoxidation and curtailing release of Tc disposed in nuclear waste repositories.

  16. PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH DAN PENGEMBANGAN KARAKTER PADA SISWA KELAS VII MELALUI MODEL PBL BERBANTUAN SCAFFOLDING

    Directory of Open Access Journals (Sweden)

    Novy Kris Zaini

    2016-04-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui (1 apakah kemampuan pemecahan masalah matematika peserta didik yang diajar dengan model PBL berbantuan scaffolding pada materi pokok segiempat kelas VII dapat mencapai KKM yang ditetapkan, (2 apakah pembelajaran matematika dengan model PBL berbantuan scaffolding pada materi pokok segiempat kelas VII dapat meningkatkan kemampuan pemecahan masalah peserta didik pilihan, (3 apakah pembelajaran matematika dengan model PBL berbantuan scaffolding pada materi pokok segiempat kelas VII dapat meningkatkan karakter rasa ingin tahu peserta didik pilihan. Desain penelitian ini adalah concurrent triangulation (campuran kuatitatif dan kualitatif secara seimbang, menggabungkan antara metode kuantitatif dan metode kualitatif untuk digunakan secara bersama-sama dalam suatu kegiatan penelitian, sehingga diperoleh data yang lebih komprehensif, valid, reliabel dan obyektif. Penentuan sumber data dalam penelitian ini menggunakan teknik triangulasi, yaitu menggabungkan dari berbagai teknik pengumpulan data dan sumber data yang telah ada. Data diperoleh dengan observasi, wawancara, dan dokumentasi yang kemudian dianalisis menggunakan analisis kualitatif, sedangkan tes dan observasi dianalisis menggunakan analisis kuantitatif dan analisis gain untuk mengukur peningkatan. Analisis kualitatif menunjukkan karakter rasa ingin tahu dan kemampuan pemecahan masalah peserta didik meningkat, serta kemampuan pemecahan masalah peserta didik mencapai KKM melalui model pembelajaran PBL

  17. MENDF71x. Multigroup Neutron Cross Section Data Tables Based upon ENDF/B-VII.1

    International Nuclear Information System (INIS)

    Conlin, Jeremy Lloyd; Parsons, Donald Kent; Gardiner, Steven J.; Gray, Mark Girard; Lee, Mary Beth; White, Morgan Curtis

    2015-01-01

    A new multi-group neutron cross section library has been released along with the release of NDI version 2.0.20. The library is named MENDF71x and is based upon the evaluations released in ENDF/B-VII.1 which was made publicly available in December 2011. ENDF/B-VII.1 consists of 423 evaluations of which ten are excited states evaluations and 413 are ground state evaluations. MENDF71x was created by processing the 423 evaluations into 618-group, downscatter only NDI data tables. The ENDF/B evaluation files were processed using NJOY version 99.393 with the exception of 35 Cl and 233 U. Those two isotopes had unique properties that required that we process the evaluation using NJOY version 2012. The MENDF71x library was only processed to room temperature, i.e., 293.6 K. In the future, we plan on producing a multi-temperature library based on ENDF/B-VII.1 and compatible with MENDF71x.

  18. KEEFEKTIFAN MODEL PEMBELAJARAN KOOPERATIF TIPE SQ3R TERHADAP KEMAMPUAN PEMECAHAN MASALAH SISWA SMP KELAS VII

    Directory of Open Access Journals (Sweden)

    Dian Teguh Firmansyah

    2012-10-01

    Full Text Available This study aims to determine the effectiveness of cooperative learning model types Survey Question Read Recite Review (SQ3R to mathematical problem solving abilities of students in the junior high school grade VII of material relationships between angles. The population in this study is students of grade VII SMP N 1 Pagerbarang school year 2011/2012. The samples taken by cluster random sampling technique so namely studentsinclassVIIB as control group and studentsinclass VIIC as experiment group. Design used in this research is true experimental design posttest only control type. Results showed that the averagetest scores mathematical problem solving abilities of students in class taught by cooperative learning model types SQ3Rof material relationships between angles achieve minimal completeness criteria(KKM applies in SMP N 1 Pagerbarang, with many students who achieve KKM is more than equal 75%, and average test scores mathematical problem solving abilities of students in classtaught by cooperative learning model typesSQ3Rof material relationships between anglesmore than the average test scoresmathematical problem solving abilities of students in class taught by expository model. Based on the research results can be concluded that the cooperative learning model types SQ3R is effective to improve students problem solving skills students grade VII to the material relationships between angles.

  19. Determinación del estado de salud bucal en pacientes discapacitados del Área VII en Cienfuegos

    Directory of Open Access Journals (Sweden)

    Ana Belkys Hernández Millán

    2014-10-01

    Full Text Available Fundamento: la discapacidad constituye una preocupación social, sin embargo, se cuenta con pocos estudios sobre el estado de salud bucal de los pacientes discapacitados. Objetivo: determinar el estado de salud bucal en pacientes discapacitados del Área VII de la provincia Cienfuegos. Métodos: se realizó un estudio descriptivo, de serie de casos, del Área VII del municipio de Cienfuegos, en el periodo de enero-diciembre de 2013. Se estudiaron 192 discapacitados que acudieron a consulta estomatológica o fueron visitados en terreno. Las variables analizadas fueron: edad, sexo, nivel de escolaridad, tipo de discapacidad, clasificación epidemiológica en cuanto al estado de salud bucal, enfermedades sistémicas, factores de riesgo a tener en cuenta para las enfermedades bucales, estado de salud bucal, periodontopatías, maloclusiones, lesiones premalignas, necesidad de prótesis total o parcial y necesidad de tratamiento en Atención Primaria o Secundaria. La información se recogió en historia clínica individual, planilla de clasificación de discapacidad. Los resultados se presentan en número y porcentaje. Resultados: el género femenino fue el más afectado, y la edad más representativa la de 35-59 años, predominaron las enfermedades crónicas degenerativas, los enfermos en la clasificación epidemiológica según estado de salud bucal, la hipertensión arterial entre las enfermedades sistémicas. Antecedentes de caries fue el factor de riesgo más relevante, resultando la gingivitis crónica edematosa, con un mayor porcentaje. Conclusiones: se determinó que la salud bucal en el grupo estudiado fue deficiente y existen dificultades por parte del Estomatólogo General Integral para tratar a estos pacientes a pesar de existir programas de atención a discapacitados.

  20. COMBINE7.0 - A Portable ENDF/B-VII.0 Based Neutron Spectrum and Cross-Section Generation Program

    Energy Technology Data Exchange (ETDEWEB)

    Woo Y. Yoon; David W. Nigg

    2008-09-01

    COMBINE7.0 is a FORTRAN 90 computer code that generates multigroup neutron constants for use in the deterministic diffusion and transport theory neutronics analysis. The cross-section database used by COMBINE7.0 is derived from the Evaluated Nuclear Data Files (ENDF/B-VII.0). The neutron energy range covered is from 20 MeV to 1.0E-5 eV. The Los Alamos National Laboratory NJOY code is used as the processing code to generate a 167 finegroup cross-section library in MATXS format for Bondarenko self-shielding treatment. Resolved resonance parameters are extracted from ENDF/B-VII.0 File 2 for a separate library to be used in an alternate Nordheim self-shielding treatment in the resolved resonance energy range. The equations solved for energy dependent neutron spectrum in the 167 fine-group structure are the B-3 or B-1 approximations to the transport equation. The fine group cross sections needed for the spectrum calculation are first prepared by Bondarenko selfshielding interpolation in terms of background cross section and temperature. The geometric lump effect, when present, is accounted for by augmenting the background cross section. Nordheim self-shielded fine group cross sections for a material having resolved resonance parameters overwrite correspondingly the existing self-shielded fine group cross sections when this option is used. The fine group cross sections in the thermal energy range are replaced by those selfshielded with the Amouyal/Benoist/Horowitz method in the three region geometry when this option is requested. COMBINE7.0 coalesces fine group cross sections into broad group macroscopic and microscopic constants. The coalescing is performed by utilizing fine-group fluxes and/or currents obtained by spectrum calculation as the weighting functions. The multigroup constant may be output in any of several standard formats including ANISN 14** free format, CCCC ISOTXS format, and AMPX working library format. ANISN-PC, a onedimensional, discrete