3' fragment of miR173-programmed RISC-cleaved RNA is protected from degradation in a complex with RISC and SGS3.

Science.gov (United States)

Yoshikawa, Manabu; Iki, Taichiro; Tsutsui, Yasuhiro; Miyashita, Kyoko; Poethig, R Scott; Habu, Yoshiki; Ishikawa, Masayuki

2013-03-05

trans-acting small interfering RNAs (tasiRNAs) are plant-specific endogenous siRNAs produced via a unique pathway whose first step is the microRNA (miRNA)-programmed RNA-induced silencing complex (RISC)-mediated cleavage of tasiRNA gene (TAS) transcripts. One of the products is subsequently transformed into tasiRNAs by a pathway that requires several factors including SUPPRESSOR OF GENE SILENCING3 (SGS3) and RNA-DEPENDENT RNA POLYMERASE6. Here, using in vitro assembled ARGONAUTE (AGO)1-RISCs, we show that SGS3 is recruited onto RISCs only when they bind target RNA. Following cleavage by miRNA173 (miR173)-programmed RISC, SGS3 was found in complexes containing cleaved TAS2 RNA and RISC. The 3' cleavage fragment (the source of tasiRNAs) was protected from degradation in this complex. Depletion of SGS3 did not affect TAS2 RNA cleavage by miR173-programmed RISC, but did affect the stability of the 3' cleavage fragment. When the 3' nucleotide of 22-nt miR173 was deleted or the corresponding nucleotide in TAS2 RNA was mutated, the complex was not observed and the 3' cleavage fragment was degraded. Importantly, these changes in miR173 or TAS2 RNA are known to lead to a loss of tasiRNA production in vivo. These results suggest that (i) SGS3 associates with AGO1-RISC via the double-stranded RNA formed by the 3'-terminal nucleotides of 22-nt miR173 and corresponding target RNA, which probably protrudes from the AGO1-RISC molecular surface, (ii) SGS3 protects the 3' cleavage fragment of TAS2 RNA from degradation, and (iii) the observed SGS3-dependent stabilization of the 3' fragment of TAS2 RNA is key to tasiRNA production.

In vitro reconstitution of chaperone-mediated human RISC assembly.

Science.gov (United States)

Naruse, Ken; Matsuura-Suzuki, Eriko; Watanabe, Mariko; Iwasaki, Shintaro; Tomari, Yukihide

2018-01-01

To silence target mRNAs, small RNAs and Argonaute (Ago) proteins need to be assembled into RNA-induced silencing complexes (RISCs). Although the assembly of Drosophila melanogaster RISC was recently reconstituted by Ago2, the Dicer-2/R2D2 heterodimer, and five chaperone proteins, the absence of a reconstitution system for mammalian RISC assembly has posed analytical challenges. Here we describe reconstitution of human RISC assembly using Ago2 and five recombinant chaperone proteins: Hsp90β, Hsc70, Hop, Dnaja2, and p23. Our data show that ATP hydrolysis by both Hsp90β and Hsc70 is required for RISC assembly of small RNA duplexes but not for that of single-stranded RNAs. The reconstitution system lays the groundwork for further studies of small RNA-mediated gene silencing in mammals. © 2018 Naruse et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

Single-Molecule Analysis for RISC Assembly and Target Cleavage.

Science.gov (United States)

Sasaki, Hiroshi M; Tadakuma, Hisashi; Tomari, Yukihide

2018-01-01

RNA-induced silencing complex (RISC) is a small RNA-protein complex that mediates silencing of complementary target RNAs. Biochemistry has been successfully used to characterize the molecular mechanism of RISC assembly and function for nearly two decades. However, further dissection of intermediate states during the reactions has been warranted to fill in the gaps in our understanding of RNA silencing mechanisms. Single-molecule analysis with total internal reflection fluorescence (TIRF) microscopy is a powerful imaging-based approach to interrogate complex formation and dynamics at the individual molecule level with high sensitivity. Combining this technique with our recently established in vitro reconstitution system of fly Ago2-RISC, we have developed a single-molecule observation system for RISC assembly. In this chapter, we summarize the detailed protocol for single-molecule analysis of chaperone-assisted assembly of fly Ago2-RISC as well as its target cleavage reaction.

Blood interaction with a Bioline heparin coated HIA-VAD : A study on calves

NARCIS (Netherlands)

vanderKamp, KWHJ; Magielse, CPE; Elstrodt, JM; vanderMeer, J; vanOeveren, W; Rakhorst, G

The blood compatibility of ventricular assist devices developed by the Helmholtz institute Aachen (HA-VAD's) was tested on calves. Seven calves received a non-coated HIA-VAD (control) and three a Bioline heparin coated device. The circulatory support of these HIA-VAD's lasted one week. Mechanical

De predictieve validiteit van de Recidive Inschattingsschalen (RISc)

NARCIS (Netherlands)

Knaap, L.M. van der; Alberda, D.L.

2009-01-01

Om inzichten te krijgen in criminogene factoren van delinquenten is het screeningsinstrument 'Recidive Inschattingsschalen' (RISc) ontwikkeld. De betrouwbaarheid en validiteit van dit instrument zijn al onderzocht en positief bevonden. Dit onderzoek gaat na of de RISc geschikt is als

RNA helicase A is not required for RISC activity.

Science.gov (United States)

Liang, Xue-Hai; Crooke, Stanley T

2013-10-01

It has been shown that siRNAs can compete with each other or with endogenous miRNAs for RISC components. This competition may complicate the interpretations of phenotypes observed through siRNA-mediated knockdown of genes, especially those genes implicated in the RISC pathway. In this study, we re-examined the function of RNA helicase A (RHA), which has been previously proposed to function in RISC loading based on siRNA-mediated knockdown studies. Here we show that reduced RISC activity or loading of siRNAs was observed only in cells depleted of RHA using siRNA, but not using RNaseH-dependent antisense oligonucleotides (ASOs), suggesting that the impaired RISC function stems from the competition between pre-existing and newly transfected siRNAs, but not from reduction of the RHA protein. This view is further supported by the findings that cells depleted of a control protein, NCL1, using siRNA, but not ASO, exhibited similar defects on the loading and activity of a subsequently transfected siRNA. Transfection of RHA or NCL1 siRNAs, but not ASOs, reduced the levels of endogenous miRNAs, suggesting a competition mechanism. As a positive control, we showed that reduction of MOV10 by either siRNA or ASO decreased siRNA activity, confirming its role in RISC function. Together, our results indicate that RHA is not required for RISC activity or loading, and suggest that proper controls are required when using siRNAs to functionalize genes to avoid competition effects. © 2013. Published by Elsevier B.V. All rights reserved.

Functional Verification of Enhanced RISC Processor

OpenAIRE

SHANKER NILANGI; SOWMYA L

2013-01-01

This paper presents design and verification of a 32-bit enhanced RISC processor core having floating point computations integrated within the core, has been designed to reduce the cost and complexity. The designed 3 stage pipelined 32-bit RISC processor is based on the ARM7 processor architecture with single precision floating point multiplier, floating point adder/subtractor for floating point operations and 32 x 32 booths multiplier added to the integer core of ARM7. The binary representati...

3′ fragment of miR173-programmed RISC-cleaved RNA is protected from degradation in a complex with RISC and SGS3

Science.gov (United States)

Yoshikawa, Manabu; Iki, Taichiro; Tsutsui, Yasuhiro; Miyashita, Kyoko; Poethig, R. Scott; Habu, Yoshiki; Ishikawa, Masayuki

2013-01-01

trans-acting small interfering RNAs (tasiRNAs) are plant-specific endogenous siRNAs produced via a unique pathway whose first step is the microRNA (miRNA)-programmed RNA-induced silencing complex (RISC)–mediated cleavage of tasiRNA gene (TAS) transcripts. One of the products is subsequently transformed into tasiRNAs by a pathway that requires several factors including SUPPRESSOR OF GENE SILENCING3 (SGS3) and RNA-DEPENDENT RNA POLYMERASE6. Here, using in vitro assembled ARGONAUTE (AGO)1–RISCs, we show that SGS3 is recruited onto RISCs only when they bind target RNA. Following cleavage by miRNA173 (miR173)-programmed RISC, SGS3 was found in complexes containing cleaved TAS2 RNA and RISC. The 3′ cleavage fragment (the source of tasiRNAs) was protected from degradation in this complex. Depletion of SGS3 did not affect TAS2 RNA cleavage by miR173-programmed RISC, but did affect the stability of the 3′ cleavage fragment. When the 3′ nucleotide of 22-nt miR173 was deleted or the corresponding nucleotide in TAS2 RNA was mutated, the complex was not observed and the 3′ cleavage fragment was degraded. Importantly, these changes in miR173 or TAS2 RNA are known to lead to a loss of tasiRNA production in vivo. These results suggest that (i) SGS3 associates with AGO1–RISC via the double-stranded RNA formed by the 3′-terminal nucleotides of 22-nt miR173 and corresponding target RNA, which probably protrudes from the AGO1–RISC molecular surface, (ii) SGS3 protects the 3′ cleavage fragment of TAS2 RNA from degradation, and (iii) the observed SGS3-dependent stabilization of the 3′ fragment of TAS2 RNA is key to tasiRNA production. PMID:23417299

RISC-interacting clearing 3’- 5’ exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana

Science.gov (United States)

Zhang, Zhonghui; Hu, Fuqu; Sung, Min Woo; Shu, Chang; Castillo-González, Claudia; Koiwa, Hisashi; Tang, Guiliang; Dickman, Martin; Li, Pingwei; Zhang, Xiuren

2017-01-01

RNA-induced silencing complex (RISC) is composed of miRNAs and AGO proteins. AGOs use miRNAs as guides to slice target mRNAs to produce truncated 5' and 3' RNA fragments. The 5' cleaved RNA fragments are marked with uridylation for degradation. Here, we identified novel cofactors of Arabidopsis AGOs, named RICE1 and RICE2. RICE proteins specifically degraded single-strand (ss) RNAs in vitro; but neither miRNAs nor miRNA*s in vivo. RICE1 exhibited a DnaQ-like exonuclease fold and formed a homohexamer with the active sites located at the interfaces between RICE1 subunits. Notably, ectopic expression of catalytically-inactive RICE1 not only significantly reduced miRNA levels; but also increased 5' cleavage RISC fragments with extended uridine tails. We conclude that RICEs act to degrade uridylated 5’ products of AGO cleavage to maintain functional RISC. Our study also suggests a possible link between decay of cleaved target mRNAs and miRNA stability in RISC. DOI: http://dx.doi.org/10.7554/eLife.24466.001 PMID:28463111

An antiviral RISC isolated from Tobacco rattle virus-infected plants.

Science.gov (United States)

Ciomperlik, Jessica J; Omarov, Rustem T; Scholthof, Herman B

2011-03-30

The RNAi model predicts that during antiviral defense a RNA-induced silencing complex (RISC) is programmed with viral short-interfering RNAs (siRNAs) to target the cognate viral RNA for degradation. We show that infection of Nicotiana benthamiana with Tobacco rattle virus (TRV) activates an antiviral nuclease that specifically cleaves TRV RNA in vitro. In agreement with known RISC properties, the nuclease activity was inhibited by NaCl and EDTA and stimulated by divalent metal cations; a novel property was its preferential targeting of elongated RNA molecules. Intriguingly, the specificity of the TRV RISC could be reprogrammed by exogenous addition of RNA (containing siRNAs) from plants infected with an unrelated virus, resulting in a newly acquired ability of RISC to target this heterologous genome in vitro. Evidently the virus-specific nuclease complex from N. benthamiana represents a genuine RISC that functions as a readily employable and reprogrammable antiviral defense unit. Copyright © 2011 Elsevier Inc. All rights reserved.

AGO/RISC-mediated antiviral RNA silencing in a plant in vitro system.

Science.gov (United States)

Schuck, Jana; Gursinsky, Torsten; Pantaleo, Vitantonio; Burgyán, Jozsef; Behrens, Sven-Erik

2013-05-01

AGO/RISC-mediated antiviral RNA silencing, an important component of the plant's immune response against RNA virus infections, was recapitulated in vitro. Cytoplasmic extracts of tobacco protoplasts were applied that supported Tombusvirus RNA replication, as well as the formation of RNA-induced silencing complexes (RISC) that could be functionally reconstituted with various plant ARGONAUTE (AGO) proteins. For example, when RISC containing AGO1, 2, 3 or 5 were programmed with exogenous siRNAs that specifically targeted the viral RNA, endonucleolytic cleavages occurred and viral replication was inhibited. Antiviral RNA silencing was disabled by the viral silencing suppressor p19 when this was present early during RISC formation. Notably, with replicating viral RNA, only (+)RNA molecules were accessible to RISC, whereas (-)RNA replication intermediates were not. The vulnerability of viral RNAs to RISC activity also depended on the RNA structure of the target sequence. This was most evident when we characterized viral siRNAs (vsiRNAs) that were particularly effective in silencing with AGO1- or AGO2/RISC. These vsiRNAs targeted similar sites, suggesting that accessible parts of the viral (+)RNA may be collectively attacked by different AGO/RISC. The in vitro system was, hence, established as a valuable tool to define and characterize individual molecular determinants of antiviral RNA silencing.

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding.

Science.gov (United States)

Kawamata, Tomoko; Seitz, Hervé; Tomari, Yukihide

2009-09-01

MicroRNAs (miRNAs) regulate expression of their target mRNAs through the RNA-induced silencing complex (RISC), which contains an Argonaute (Ago) family protein as a core component. In Drosophila melanogaster, miRNAs are generally sorted into Ago1-containing RISC (Ago1-RISC). We established a native gel system that can biochemically dissect the Ago1-RISC assembly pathway. We found that miRNA-miRNA* duplexes are loaded into Ago1 as double-stranded RNAs in an ATP-dependent fashion. In contrast, unexpectedly, unwinding of miRNA-miRNA* duplexes is a passive process that does not require ATP or slicer activity of Ago1. Central mismatches direct miRNA-miRNA* duplexes into pre-Ago1-RISC, whereas mismatches in the seed or guide strand positions 12-15 promote conversion of pre-Ago1-RISC into mature Ago1-RISC. Our findings show that unwinding of miRNAs is a precise mirror-image process of target recognition, and both processes reflect the unique geometry of RNAs in Ago proteins.

Cyclophilin 40 facilitates HSP90-mediated RISC assembly in plants.

Science.gov (United States)

Iki, Taichiro; Yoshikawa, Manabu; Meshi, Tetsuo; Ishikawa, Masayuki

2012-01-18

Posttranscriptional gene silencing is mediated by RNA-induced silencing complexes (RISCs) that contain AGO proteins and single-stranded small RNAs. The assembly of plant AGO1-containing RISCs depends on the molecular chaperone HSP90. Here, we demonstrate that cyclophilin 40 (CYP40), protein phosphatase 5 (PP5), and several other proteins with the tetratricopeptide repeat (TPR) domain associates with AGO1 in an HSP90-dependent manner in extracts of evacuolated tobacco protoplasts (BYL). Intriguingly, CYP40, but not the other TPR proteins, could form a complex with small RNA duplex-bound AGO1. Moreover, CYP40 that was synthesized by in-vitro translation using BYL uniquely facilitated binding of small RNA duplexes to AGO1, and as a result, increased the amount of mature RISCs that could cleave target RNAs. CYP40 was not contained in mature RISCs, indicating that the association is transient. Addition of PP5 or cyclophilin-binding drug cyclosporine A prevented the association of endogenous CYP40 with HSP90-AGO1 complex and inhibited RISC assembly. These results suggest that a complex of AGO1, HSP90, CYP40, and a small RNA duplex is a key intermediate of RISC assembly in plants.

Proposta e simulação de uma arquitetura RISC

OpenAIRE

Fredy Joao Valente

1991-01-01

RISC - Uma nova tendência em arquitetura de computadores. Este trabalho apresenta um estudo de como surgiu esta nova arquitetura, e suas características básicas, que a diferencia das arquiteturas convencionais. Uma proposta de microprocessador RISC é apresentada, com sua rota de dados completamente detalhada. Um simulador para arquitetura RISC foi então construído, para se testar este microprocessador. Para validar o simulador, que é a idéia principal deste trabalho, e para se avaliar a arqui...

The Radiation, Interplanetary Shocks, and Coronal Sources (RISCS) Toolset

Science.gov (United States)

Zank, G. P.; Spann, James F.

2014-01-01

The goal of this project is to serve the needs of space system designers and operators by developing an interplanetary radiation environment model within 10 AU:Radiation, Interplanetary Shocks, and Coronal Sources (RISCS) toolset: (1) The RISCS toolset will provide specific reference environments for space system designers and nowcasting and forecasting capabilities for space system operators; (2) We envision the RISCS toolset providing the spatial and temporal radiation environment external to the Earth's (and other planets') magnetosphere, as well as possessing the modularity to integrate separate applications (apps) that can map to specific magnetosphere locations and/or perform the subsequent radiation transport and dosimetry for a specific target.

Multilayer checkpoints for microRNA authenticity during RISC assembly.

Science.gov (United States)

Kawamata, Tomoko; Yoda, Mayuko; Tomari, Yukihide

2011-09-01

MicroRNAs (miRNAs) function through the RNA-induced silencing complex (RISC), which contains an Argonaute (Ago) protein at the core. RISC assembly follows a two-step pathway: miRNA/miRNA* duplex loading into Ago, and separation of the two strands within Ago. Here we show that the 5' phosphate of the miRNA strand is essential for duplex loading into Ago, whereas the preferred 5' nucleotide of the miRNA strand and the base-pairing status in the seed region and the middle of the 3' region function as additive anchors to Ago. Consequently, the miRNA authenticity is inspected at multiple steps during RISC assembly.

IBM 3705 Communications Controller

CERN Multimedia

1972-01-01

The IBM 3705 Communications Controller is a simple computer which attaches to an IBM System/360 or System/370. Its purpose is to connect communication lines to the mainframe channel. It was a first communications controller of the popular IBM 37xx series.

An in vitro reprogrammable antiviral RISC with size-preferential ribonuclease activity.

Science.gov (United States)

Omarov, Rustem T; Ciomperlik, Jessica; Scholthof, Herman B

2016-03-01

Infection of Nicotiana benthamiana plants with Tomato bushy stunt virus (TBSV) mutants compromised for silencing suppression induces formation of an antiviral RISC (vRISC) that can be isolated using chromatography procedures. The isolated vRISC sequence-specifically degrades TBSV RNA in vitro, its activity can be down-regulated by removing siRNAs, and re-stimulated by exogenous supply of siRNAs. vRISC is most effective at hydrolyzing the ~4.8kb genomic RNA, but less so for a ~2.2kb TBSV subgenomic mRNA (sgRNA1), while the 3' co-terminal sgRNA2 of ~0.9kb appears insensitive to vRISC cleavage. Moreover, experiments with in vitro generated 5' co-terminal viral transcripts show that RNAs of ~2.7kb are efficiently cleaved while those of ~1.1kb or shorter are unaffected. The isolated antiviral ribonuclease complex fails to degrade ~0.4kb defective interfering RNAs (DIs) in vitro, agreeing with findings that in plants DIs are not targeted by silencing. Copyright © 2016. Published by Elsevier Inc.

Electroencephalogram (EEG spectral features discriminate between Alzheimer’s (AD and Vascular dementia (VaD

Directory of Open Access Journals (Sweden)

Emanuel eNeto

2015-02-01

Full Text Available Alzheimer’s disease (AD and vascular dementia (VaD present with similar clinical symptoms of cognitive decline, but the underlying pathophysiological mechanisms differ. To determine whether clinical electroencephalography (EEG can provide information relevant to discriminate between these diagnoses, we used quantitative EEG analysis to compare the spectra between non-medicated patients with AD (n=77 and VaD (n=77 and healthy elderly normal controls (NC (n=77. We use curve-fitting with a combination of a power loss and Gaussian function to model the averaged resting-state spectra of each EEG channel extracting six parameters. We assessed the performance of our model and tested the extracted parameters for group differentiation. We performed regression analysis in a MANCOVA with group, age, gender, and number of epochs as predictors and further explored the topographical group differences with pair-wise contrasts. Significant topographical differences between the groups were found in several of the extracted features. Both AD and VaD groups showed increased delta power when compared to NC, whereas the AD patients showed a decrease in alpha power for occipital and temporal regions when compared with NC. The VaD patients had higher alpha power than NC and AD. The AD and VaD groups showed slowing of the alpha rhythm. Variability of the alpha frequency was wider for both AD and VaD groups. There was a general decrease in beta power for both AD and VaD. The proposed model is a useful to parameterize spectra which allowed extracting relevant clinical EEG key features that move towards simple and interpretable diagnostic criteria.

16-Bit RISC Processor Design for Convolution Application

OpenAIRE

Anand Nandakumar Shardul

2013-01-01

In this project, we propose a 16-bit non-pipelined RISC processor, which is used for signal processing applications. The processor consists of the blocks, namely, program counter, clock control unit, ALU, IDU and registers. Advantageous architectural modifications have been made in the incremented circuit used in program counter and carry select adder unit of the ALU in the RISC CPU core. Furthermore, a high speed and low power modified modifies multiplier has been designed and introduced in ...

Differential RISC association of endogenous human microRNAs predicts their inhibitory potential.

Science.gov (United States)

Flores, Omar; Kennedy, Edward M; Skalsky, Rebecca L; Cullen, Bryan R

2014-04-01

It has previously been assumed that the generally high stability of microRNAs (miRNAs) reflects their tight association with Argonaute (Ago) proteins, essential components of the RNA-induced silencing complex (RISC). However, recent data have suggested that the majority of mature miRNAs are not, in fact, Ago associated. Here, we demonstrate that endogenous human miRNAs vary widely, by >100-fold, in their level of RISC association and show that the level of Ago binding is a better indicator of inhibitory potential than is the total level of miRNA expression. While miRNAs of closely similar sequence showed comparable levels of RISC association in the same cell line, these varied between different cell types. Moreover, the level of RISC association could be modulated by overexpression of complementary target mRNAs. Together, these data indicate that the level of RISC association of a given endogenous miRNA is regulated by the available RNA targetome and predicts miRNA function.

NHLBI's program for VAD therapy for moderately advanced heart failure: the REVIVE-IT pilot trial.

Science.gov (United States)

Baldwin, J Timothy; Mann, Douglas L

2010-11-01

Ventricular assist devices (VADs) are used to bridge heart failure patients to transplantation, to allow their own hearts to recover, or as permanent ("destination") therapy. To date, the use of VADs has been limited to late-stage heart failure patients because of the associated device risks. In 2008, a National Heart, Lung, and Blood Institute (NHLBI) working group met to evaluate the treatment of heart failure using VADs and to advise the institute on how therapy for heart failure may be best advanced by clinical trials involving the devices. Recognizing the improvements in VAD technology and in patient care and selection over the past decade, the working group recommended that a trial be performed to assess the use of chronic VAD therapy in patients who are less ill than those currently eligible for destination therapy. The hypothesis proposed for the trial is that VAD therapy may improve both survival and quality of life in moderately advanced heart failure patients who are neither inotrope-dependent nor exercise-intolerant and have not yet developed serious consequences such as malnourishment, end-organ damage, and immobility. Based on the group's recommendations, NHLBI issued an RFP in 2009 for the REVIVE-IT Pilot Trail, which will serve to test the hypothesis and inform the pivotal trial. Published by Elsevier Inc.

RISC RNA sequencing for context-specific identification of in vivo microRNA targets.

Science.gov (United States)

Matkovich, Scot J; Van Booven, Derek J; Eschenbacher, William H; Dorn, Gerald W

2011-01-07

MicroRNAs (miRs) are expanding our understanding of cardiac disease and have the potential to transform cardiovascular therapeutics. One miR can target hundreds of individual mRNAs, but existing methodologies are not sufficient to accurately and comprehensively identify these mRNA targets in vivo. To develop methods permitting identification of in vivo miR targets in an unbiased manner, using massively parallel sequencing of mouse cardiac transcriptomes in combination with sequencing of mRNA associated with mouse cardiac RNA-induced silencing complexes (RISCs). We optimized techniques for expression profiling small amounts of RNA without introducing amplification bias and applied this to anti-Argonaute 2 immunoprecipitated RISCs (RISC-Seq) from mouse hearts. By comparing RNA-sequencing results of cardiac RISC and transcriptome from the same individual hearts, we defined 1645 mRNAs consistently targeted to mouse cardiac RISCs. We used this approach in hearts overexpressing miRs from Myh6 promoter-driven precursors (programmed RISC-Seq) to identify 209 in vivo targets of miR-133a and 81 in vivo targets of miR-499. Consistent with the fact that miR-133a and miR-499 have widely differing "seed" sequences and belong to different miR families, only 6 targets were common to miR-133a- and miR-499-programmed hearts. RISC-sequencing is a highly sensitive method for general RISC profiling and individual miR target identification in biological context and is applicable to any tissue and any disease state.

Bill Lang's contributions to acoustics at the International Business Machines Corp. (IBM) and to IBM in general

Science.gov (United States)

Nobile, Matthew A.; Chu, Richard C.

2005-09-01

Although Bill Lang's accomplishments and key roles in national and international standards and in the formation of INCE are widely recognized, sometimes it has to be remembered that for nearly 35 years he also had a ``day job'' at the IBM Corporation. His achievements at IBM were no less significant and enduring than those in external standards and professional societies. This paper will highlight some of the accomplishments and activities of Bill Lang as an IBM noise control engineer, the creator of the IBM Acoustics Lab in Poughkeepsie, the founder of the global Acoustics program at IBM, and his many other IBM leadership roles. Bill was also a long-serving IBM manager, with the full set of personnel issues to deal with, so his people-management skills were often called into play. Bill ended his long and fruitful IBM career at a high point. In 1988, he took an original idea of his to the top of IBM executive management, which led directly to the formation of the IBM Academy of Technology, today the preeminent body of IBM top technical leaders from around the world.

IBM 5150 computer

CERN Multimedia

1981-01-01

IBM’s first personal computer arrived nearly 10 years after others companies, but instantly legitimized the market. IBM introduced its PC in 1981. IBM equipped the model 5150 with a cassette port for connecting a cassette drive. The first IBM PC ran on a 4.77 MHz Intel 8088 microprocessor. The PC came equipped with 16 kilobytes of memory, expandable to 256k. The PC came with one or two 160k floppy disk drives and an optional color monitor. The price tag started at $1,565, which would be nearly $4,000 (about €3,400) today.

C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation.

Science.gov (United States)

Liu, Ying; Ye, Xuecheng; Jiang, Feng; Liang, Chunyang; Chen, Dongmei; Peng, Junmin; Kinch, Lisa N; Grishin, Nick V; Liu, Qinghua

2009-08-07

The catalytic engine of RNA interference (RNAi) is the RNA-induced silencing complex (RISC), wherein the endoribonuclease Argonaute and single-stranded small interfering RNA (siRNA) direct target mRNA cleavage. We reconstituted long double-stranded RNA- and duplex siRNA-initiated RISC activities with the use of recombinant Drosophila Dicer-2, R2D2, and Ago2 proteins. We used this core reconstitution system to purify an RNAi regulator that we term C3PO (component 3 promoter of RISC), a complex of Translin and Trax. C3PO is a Mg2+-dependent endoribonuclease that promotes RISC activation by removing siRNA passenger strand cleavage products. These studies establish an in vitro RNAi reconstitution system and identify C3PO as a key activator of the core RNAi machinery.

NHLBI’s Program for VAD Therapy for Moderately Advanced Heart Failure: The REVIVE-IT Pilot Trial

Science.gov (United States)

Baldwin, J. Timothy; Mann, Douglas L.

2010-01-01

Background VADs are used to bridge heart failure patients to transplantation, to allow their own hearts to recover, or as permanent (“destination”) therapy. To date, the use of VADs has been limited to late-stage heart failure patients because of the associated device risks. In 2008, an NHLBI working group met to evaluate the treatment of heart failure using VADs and to advise the institute on how therapy for heart failure may be best advanced by clinical trials involving the devices. Discussion and Recommendations Recognizing the improvements in VAD technology and in patient care and selection over the past decade, the working group recommended that a trial be performed to assess the use of chronic VAD therapy in patients who are less ill than those currently eligible for destination therapy. The hypothesis proposed for the trial is that VAD therapy may improve both survival and quality of life in moderately advanced heart failure patients who are neither inotrope-dependent nor exercise-intolerant and have not yet developed serious consequences such as malnourishment, end-organ damage, and immobility. Based on the group’s recommendations, NHLBI issued an RFP in 2009 for the REVIVE-IT Pilot Trail which will serve to test the hypothesis and inform the pivotal trial. PMID:21055648

Autoantigen La promotes efficient RNAi, antiviral response, and transposon silencing by facilitating multiple-turnover RISC catalysis.

Science.gov (United States)

Liu, Ying; Tan, Huiling; Tian, Hui; Liang, Chunyang; Chen, She; Liu, Qinghua

2011-11-04

The effector of RNA interference (RNAi) is the RNA-induced silencing complex (RISC). C3PO promotes the activation of RISC by degrading the Argonaute2 (Ago2)-nicked passenger strand of duplex siRNA. Active RISC is a multiple-turnover enzyme that uses the guide strand of siRNA to direct the Ago2-mediated sequence-specific cleavage of complementary mRNA. How this effector step of RNAi is regulated is currently unknown. Here, we used the human Ago2 minimal RISC system to purify Sjögren's syndrome antigen B (SSB)/autoantigen La as an activator of the RISC-mediated mRNA cleavage activity. Our reconstitution studies showed that La could promote multiple-turnover RISC catalysis by facilitating the release of cleaved mRNA from RISC. Moreover, we demonstrated that La was required for efficient RNAi, antiviral defense, and transposon silencing in vivo. Taken together, the findings of C3PO and La reveal a general concept that regulatory factors are required to remove Ago2-cleaved products to assemble or restore active RISC. Copyright © 2011 Elsevier Inc. All rights reserved.

A scoring system for ascertainment of incident stroke; the Risk Index Score (RISc).

Science.gov (United States)

Kass-Hout, T A; Moyé, L A; Smith, M A; Morgenstern, L B

2006-01-01

The main objective of this study was to develop and validate a computer-based statistical algorithm that could be translated into a simple scoring system in order to ascertain incident stroke cases using hospital admission medical records data. The Risk Index Score (RISc) algorithm was developed using data collected prospectively by the Brain Attack Surveillance in Corpus Christi (BASIC) project, 2000. The validity of RISc was evaluated by estimating the concordance of scoring system stroke ascertainment to stroke ascertainment by physician and/or abstractor review of hospital admission records. RISc was developed on 1718 randomly selected patients (training set) and then statistically validated on an independent sample of 858 patients (validation set). A multivariable logistic model was used to develop RISc and subsequently evaluated by goodness-of-fit and receiver operating characteristic (ROC) analyses. The higher the value of RISc, the higher the patient's risk of potential stroke. The study showed RISc was well calibrated and discriminated those who had potential stroke from those that did not on initial screening. In this study we developed and validated a rapid, easy, efficient, and accurate method to ascertain incident stroke cases from routine hospital admission records for epidemiologic investigations. Validation of this scoring system was achieved statistically; however, clinical validation in a community hospital setting is warranted.

A study on the effectiveness of lockup-free caches for a Reduced Instruction Set Computer (RISC) processor

OpenAIRE

Tharpe, Leonard.

1992-01-01

Approved for public release; distribution is unlimited This thesis presents a simulation and analysis of the Reduced Instruction Set Computer (RISC) architecture and the effects on RISC performance of a lockup-free cache interface. RISC architectures achieve high performance by having a small, but sufficient, instruction set with most instructions executing in one clock cycle. Current RISC performance range from 1.5 to 2.0 CPI. The goal of RISC is to attain a CPI of 1.0. The major hind...

Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma.

Science.gov (United States)

Yoo, Byoung Kwon; Santhekadur, Prasanna K; Gredler, Rachel; Chen, Dong; Emdad, Luni; Bhutia, Sujit; Pannell, Lewis; Fisher, Paul B; Sarkar, Devanand

2011-05-01

There is virtually no effective treatment for advanced hepatocellular carcinoma (HCC) and novel targets need to be identified to develop effective treatment. We recently documented that the oncogene Astrocyte elevated gene-1 (AEG-1) plays a seminal role in hepatocarcinogenesis. Employing yeast two-hybrid assay and coimmunoprecipitation followed by mass spectrometry, we identified staphylococcal nuclease domain containing 1 (SND1), a nuclease in the RNA-induced silencing complex (RISC) facilitating RNAi-mediated gene silencing, as an AEG-1 interacting protein. Coimmunoprecipitation and colocalization studies confirmed that AEG-1 is also a component of RISC and both AEG-1 and SND1 are required for optimum RISC activity facilitating small interfering RNA (siRNA) and micro RNA (miRNA)-mediated silencing of luciferase reporter gene. In 109 human HCC samples SND1 was overexpressed in ≈74% cases compared to normal liver. Correspondingly, significantly higher RISC activity was observed in human HCC cells compared to immortal normal hepatocytes. Increased RISC activity, conferred by AEG-1 or SND1, resulted in increased degradation of tumor suppressor messenger RNAs (mRNAs) that are target of oncomiRs. Inhibition of enzymatic activity of SND1 significantly inhibited proliferation of human HCC cells. As a corollary, stable overexpression of SND1 augmented and siRNA-mediated inhibition of SND1 abrogated growth of human HCC cells in vitro and in vivo, thus revealing a potential role of SND1 in hepatocarcinogenesis. We unravel a novel mechanism that overexpression of AEG-1 and SND1 leading to increased RISC activity might contribute to hepatocarcinogenesis. Targeted inhibition of SND1 enzymatic activity might be developed as an effective therapy for HCC. Copyright © 2011 American Association for the Study of Liver Diseases.

Summary inside IBM's historic turnaround

CERN Document Server

2014-01-01

This work offers a summary of the book "WHO SAYS ELEPHANTS CAN'T DANCE? Inside IBM's Historic Turnaround" by Louis Gerstner.In nine years as the chairman and CEO of International Business Machine Corporation (IBM), Louis Gerstner brought about a dramatic change in the company's fortunes. When he took charge, IBM was on the verge of extinction as the victim of rapid changes in the computer industry. However, instead of breaking up IBM as most analysts were suggesting, Gerstner and his management team turned the company around and restored it to a position of power and influence within the indu

Optical RISC computer

Science.gov (United States)

Guilfoyle, Peter S.; Stone, Richard V.; Hessenbruch, John M.; Zeise, Frederick F.

1993-07-01

A second generation digital optical computer (DOC II) has been developed which utilizes a RISC based operating system as its host. This 32 bit, high performance (12.8 GByte/sec), computing platform demonstrates a number of basic principals that are inherent to parallel free space optical interconnects such as speed (up to 1012 bit operations per second) and low power 1.2 fJ per bit). Although DOC II is a general purpose machine, special purpose applications have been developed and are currently being evaluated on the optical platform.

Online Help from IBM.

Science.gov (United States)

Moore, Jack

1988-01-01

The article describes the IBM/Special Needs Exchange which consists of: (1) electronic mail, conferencing, and a library of text and program files on the CompuServe Information Service; and (2) a dial-in database of special education software for IBM and compatible computers. (DB)

Argonaute pull-down and RISC analysis using 2'-O-methylated oligonucleotides affinity matrices.

Science.gov (United States)

Jannot, Guillaume; Vasquez-Rifo, Alejandro; Simard, Martin J

2011-01-01

During the last decade, several novel small non-coding RNA pathways have been unveiled, which reach out to many biological processes. Common to all these pathways is the binding of a small RNA molecule to a protein member of the Argonaute family, which forms a minimal core complex called the RNA-induced silencing complex or RISC. The RISC targets mRNAs in a sequence-specific manner, either to induce mRNA cleavage through the intrinsic activity of the Argonaute protein or to abrogate protein synthesis by a mechanism that is still under investigation. We describe here, in details, a method for the affinity chromatography of the let-7 RISC starting from extracts of the nematode Caenorhabditis elegans. Our method exploits the sequence specificity of the RISC and makes use of biotinylated and 2'-O-methylated oligonucleotides to trap and pull-down small RNAs and their associated proteins. Importantly, this technique may easily be adapted to target other small RNAs expressed in different cell types or model organisms. This method provides a useful strategy to identify the proteins associated with the RISC, and hence gain insight in the functions of small RNAs.

The RISC-spectrometer experiment

International Nuclear Information System (INIS)

Pinter, Gy.

1981-01-01

The RISC (Relativistic Ionising Streamer Chamber) spectrometer (situated at Protvino, joining the accelerator) is discussed, and the experiment carried out in international cooperation is presented. The beam monitor, the trigger system and the control and data recording system as well as the streamer spark chamber are detailed (the latter is the largest of our time). Examples of the main experiments as well as the work carried out in Budapest are discussed briefly. (Sz.J.)

The inhibition of human T cell proliferation by the caspase inhibitor z-VAD-FMK is mediated through oxidative stress

Energy Technology Data Exchange (ETDEWEB)

Rajah, T.; Chow, S.C., E-mail: chow.sek.chuen@monash.edu

2014-07-15

The caspase inhibitor benzyloxycarbony (Cbz)-L-Val-Ala-Asp (OMe)-fluoromethylketone (z-VAD-FMK) has recently been shown to inhibit T cell proliferation without blocking caspase-8 and caspase-3 activation in primary T cells. We showed in this study that z-VAD-FMK treatment leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. The inhibition of anti-CD3-mediated T cell proliferation induced by z-VAD-FMK was abolished by the presence of low molecular weight thiols such as GSH, N-acetylcysteine (NAC) and L-cysteine, whereas D-cysteine which cannot be metabolised to GSH has no effect. These results suggest that the depletion of intracellular GSH is the underlying cause of z-VAD-FMK-mediated inhibition of T cell activation and proliferation. The presence of exogenous GSH also attenuated the inhibition of anti-CD3-induced CD25 and CD69 expression mediated by z-VAD-FMK. However, none of the low molecular weight thiols were able to restore the caspase-inhibitory properties of z-VAD-FMK in activated T cells where caspase-8 and caspase-3 remain activated and processed into their respective subunits in the presence of the caspase inhibitor. This suggests that the inhibition of T cell proliferation can be uncoupled from the caspase-inhibitory properties of z-VAD-FMK. Taken together, the immunosuppressive effects in primary T cells mediated by z-VAD-FMK are due to oxidative stress via the depletion of GSH.

The inhibition of human T cell proliferation by the caspase inhibitor z-VAD-FMK is mediated through oxidative stress

International Nuclear Information System (INIS)

Rajah, T.; Chow, S.C.

2014-01-01

The caspase inhibitor benzyloxycarbony (Cbz)-L-Val-Ala-Asp (OMe)-fluoromethylketone (z-VAD-FMK) has recently been shown to inhibit T cell proliferation without blocking caspase-8 and caspase-3 activation in primary T cells. We showed in this study that z-VAD-FMK treatment leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. The inhibition of anti-CD3-mediated T cell proliferation induced by z-VAD-FMK was abolished by the presence of low molecular weight thiols such as GSH, N-acetylcysteine (NAC) and L-cysteine, whereas D-cysteine which cannot be metabolised to GSH has no effect. These results suggest that the depletion of intracellular GSH is the underlying cause of z-VAD-FMK-mediated inhibition of T cell activation and proliferation. The presence of exogenous GSH also attenuated the inhibition of anti-CD3-induced CD25 and CD69 expression mediated by z-VAD-FMK. However, none of the low molecular weight thiols were able to restore the caspase-inhibitory properties of z-VAD-FMK in activated T cells where caspase-8 and caspase-3 remain activated and processed into their respective subunits in the presence of the caspase inhibitor. This suggests that the inhibition of T cell proliferation can be uncoupled from the caspase-inhibitory properties of z-VAD-FMK. Taken together, the immunosuppressive effects in primary T cells mediated by z-VAD-FMK are due to oxidative stress via the depletion of GSH

BakeCMS satura vadības sistēma

OpenAIRE

Znotiņš, Artūrs

2012-01-01

Kvalifikācijas darbs apraksta izstrādātu BakeCMS satura vadības sistēmu, kas piedāvā ērti pielāgojamu tīmekļa vietņu administrēšanas paneli. Sistēma tīmekļa vietnes administratoram nodrošina ērtu veidu, kā rediģēt vietnes tekstuālo un vizuālo informāciju. BeakeCMS sevī ietver jau gatavus biežāk nepieciešamos lapas satura vadības moduļus un piedāvā programmatūras saskarni (API), kas atvieglo jaunu moduļu izstrādi un esošo pielāgošanu konkrētās vietnes vajadzībām. Izstrāde ir pilnībā dokumentēt...

Anatomy of RISC: how do small RNAs and chaperones activate Argonaute proteins?

Science.gov (United States)

Nakanishi, Kotaro

2016-09-01

RNA silencing is a eukaryote-specific phenomenon in which microRNAs and small interfering RNAs degrade messenger RNAs containing a complementary sequence. To this end, these small RNAs need to be loaded onto an Argonaute protein (AGO protein) to form the effector complex referred to as RNA-induced silencing complex (RISC). RISC assembly undergoes multiple and sequential steps with the aid of Hsc70/Hsp90 chaperone machinery. The molecular mechanisms for this assembly process remain unclear, despite their significance for the development of gene silencing techniques and RNA interference-based therapeutics. This review dissects the currently available structures of AGO proteins and proposes models and hypotheses for RISC assembly, covering the conformation of unloaded AGO proteins, the chaperone-assisted duplex loading, and the slicer-dependent and slicer-independent duplex separation. The differences in the properties of RISC between prokaryotes and eukaryotes will also be clarified. WIREs RNA 2016, 7:637-660. doi: 10.1002/wrna.1356 For further resources related to this article, please visit the WIREs website. © 2016 The Authors. WIREs RNA published by Wiley Periodicals, Inc.

Psychometrische kwaliteiten van de Recidive Inschattingsschalen (RISc) : Interbeoordelaarsbetrouwbaarheid, interne consistentie en congruente validiteit

NARCIS (Netherlands)

Knaap, L.M. van der; Leenarts, L.E.W.; Nijssen, L.T.J.

2007-01-01

Het instrument Recidive Inschattings Schalen (RISc) is gebaseerd op een Engelstalig instrument (OASys). Tijdens de ontwikkeling van de RISc is aandacht besteed aan de vertaling van het instrument, aan de kwaliteit van de items en aan de interne consistentie van de schalen van het instrument. Verder

Slicer-independent mechanism drives small-RNA strand separation during human RISC assembly.

Science.gov (United States)

Park, June Hyun; Shin, Chanseok

2015-10-30

Small RNA silencing is mediated by the effector RNA-induced silencing complex (RISC) that consists of an Argonaute protein (AGOs 1-4 in humans). A fundamental step during RISC assembly involves the separation of two strands of a small RNA duplex, whereby only the guide strand is retained to form the mature RISC, a process not well understood. Despite the widely accepted view that 'slicer-dependent unwinding' via passenger-strand cleavage is a prerequisite for the assembly of a highly complementary siRNA into the AGO2-RISC, here we show by careful re-examination that 'slicer-independent unwinding' plays a more significant role in human RISC maturation than previously appreciated, not only for a miRNA duplex, but, unexpectedly, for a highly complementary siRNA as well. We discovered that 'slicer-dependency' for the unwinding was affected primarily by certain parameters such as temperature and Mg(2+). We further validate these observations in non-slicer AGOs (1, 3 and 4) that can be programmed with siRNAs at the physiological temperature of humans, suggesting that slicer-independent mechanism is likely a common feature of human AGOs. Our results now clearly explain why both miRNA and siRNA are found in all four human AGOs, which is in striking contrast to the strict small-RNA sorting system in Drosophila. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

RISC-Target Interaction: Cleavage and Translational Suppression

Science.gov (United States)

van den Berg, Arjen; Mols, Johann; Han, Jiahuai

2008-01-01

Summary Small RNA molecules have been known and utilized to suppress gene expression for more than a decade. The discovery that these small RNA molecules are endogenously expressed in many organisms and have a critical role in controlling gene expression have led to the arising of a whole new field of research. Termed small interfering RNA (siRNA) or microRNA (miRNA) these ~22 nt RNA molecules have the capability to suppress gene expression through various mechanisms once they are incorporated in the multi-protein RNA-Induced Silencing Complex (RISC) and interact with their target mRNA. This review introduces siRNAs and microRNAs in a historical perspective and focuses on the key molecules in RISC, structural properties and mechanisms underlying the process of small RNA regulated post-transcriptional suppression of gene expression. PMID:18692607

A Fault-tolerant RISC Microprocessor for Spacecraft Applications

Science.gov (United States)

Timoc, Constantin; Benz, Harry

1990-01-01

Viewgraphs on a fault-tolerant RISC microprocessor for spacecraft applications are presented. Topics covered include: reduced instruction set computer; fault tolerant registers; fault tolerant ALU; and double rail CMOS logic.

IBM model M keyboard

CERN Multimedia

1985-01-01

In 1985, the IBM Model M keyboard was created. This timeless classic was a hit. IBM came out with several varients of the model M. They had the space saver 104 key which is the one most seen today and many international versions of that as well. The second type, and rarest is the 122 key model M which has 24 extra keys at the very top, dubbed the “programmers keyboard”. IBM manufactured these keyboards until 1991. The model M features “caps” over the actual keys that can be taken off separately one at a time for cleaning or to replace them with colored keys or keys of another language, that was a very cost effective way of shipping out internationally the keyboards.

Color perception differentiates Alzheimer's Disease (AD) from Vascular Dementia (VaD) patients.

Science.gov (United States)

Arnaoutoglou, N A; Arnaoutoglou, M; Nemtsas, P; Costa, V; Baloyannis, S J; Ebmeier, K P

2017-08-01

Alzheimer's Disease (AD) and Vascular Dementia (VaD) are the most common causes of dementia in older people. Both diseases appear to have similar clinical symptoms, such as deficits in attention and executive function, but specific cognitive domains are affected. Current cohort studies have shown a close relationship between αβ deposits and age-related macular degeneration (Johnson et al., 2002; Ratnayaka et al., 2015). Additionally, a close link between the thinning of the retinal nerve fiber (RNFL) and AD patients has been described, while it has been proposed that AD patients suffer from a non-specific type of color blindness (Pache et al., 2003). Our study included 103 individuals divided into three groups: A healthy control group (n = 35), AD (n = 32) according to DSM-IV-TR, NINCDS-ADRDA criteria, and VaD (n = 36) based on ΝΙΝDS-AIREN, as well as Magnetic Resonance Imaging (MRI) results. The severity of patient's cognitive impairment, was measured with the Mini-Mental State Examination (MMSE) and was classified according to the Reisberg global deterioration scale (GDS). Visual perception was examined using the Ishihara plates: "Ishihara Color Vision Test - 38 Plate." The three groups were not statistically different for demographic data (age, gender, and education). The Ishihara color blindness test has a sensitivity of 80.6% and a specificity of 87.5% to discriminate AD and VaD patients when an optimal (32.5) cut-off value of performance is used. Ishihara Color Vision Test - 38 Plate is a promising potential method as an easy and not time-consuming screening test for the differential diagnosis of dementia between AD and VaD.

8-inch IBM floppy disk

CERN Multimedia

1971-01-01

The 8-inch floppy disk was a magnetic storage disk for the data introduced commercially by IBM in 1971. It was designed by an IBM team as an inexpensive way to load data into the IBM System / 370. Plus it was a read-only bare disk containing 80 KB of data. The first read-write version was introduced in 1972 by Memorex and could contain 175 KB on 50 tracks (with 8 sectors per track). Other improvements have led to various coatings and increased capacities. Finally, it was surpassed by the mini diskette of 5.25 inches introduced in 1976.

The Early Overseas Activities of IBM in Japan

OpenAIRE

吉沢, 正広; 田中, 雅章; Masahiro, YOSHIZAWA; Masaaki, TANAKA; 愛知学院大学; 鈴鹿短期大学; / SUZUKA JUNIOR COLLEGE

1998-01-01

The purpose of this paper is to examine how IBM entered into prewar Japan and ran its wholly-owned subsidiary thereafter. Before examining something noted above, this paper surveys the process of formation of IBM and then traces its early overseas activities. Turning to the initial contacts between Japan and IBM, at first IBM carried out its mere export trade to Japan through Morimura and then Kurosawa. IBM then established its wholly-owned subsidiary, Japan Watson,in Japan to expand the busi...

Psychometric Evaluation of the Connor-Davidson Resilience Scale (CD-RISC) Using Iranian Students

Science.gov (United States)

Khoshouei, Mahdieh Sadat

2009-01-01

The purpose of this study was to evaluate the psychometric properties of the Persian version of the Connor-Davidson Resilience Scale (CD-RISC). The CD-RISC was completed by a sample of 323 Isfahan university students (168 females, 155 males) aged 19-34 years. A maximum likelihood method with an oblique solution resulted in four factors…

AVR RISC microcontroller handbook

CERN Document Server

Kuhnel, Claus

1998-01-01

The AVR RISC Microcontroller Handbook is a comprehensive guide to designing with Atmel's new controller family, which is designed to offer high speed and low power consumption at a lower cost. The main text is divided into three sections: hardware, which covers all internal peripherals; software, which covers programming and the instruction set; and tools, which explains using Atmel's Assembler and Simulator (available on the Web) as well as IAR's C compiler.Practical guide for advanced hobbyists or design professionalsDevelopment tools and code available on the Web

RISC processing in Fastbus

International Nuclear Information System (INIS)

Atiya, M.; Haggerty, J.; Ng, C.; Sambamurti, A.; Strzelinski, R.

1990-01-01

This paper reports on the designed, construction and testing microprocessor based controller for data acquisition and analysis conforming to the IEEE-960 Fastbus standard. The controller uses the RISC AM29000 processor and the Am29027 floating point co-processor. The module functions as a Fastbus slave and is used for analysis and filtering of digitially sampled waveforms acquired in a large system of high performance transient digitizers (over 200 channels, each sampling at 500 MHz. with 8 bits of dynamic range). With modifications the module can operate as a Fastbus master

IBM eile, täna ja homme / Kalle Kose

Index Scriptorium Estoniae

Kose, Kalle

2007-01-01

Infotehnoloogiafirma IBM arengust. Lisatud joonised: PC tootjate turuosad (1984-2004); IBM-i käive segmentide lõikes (2000-2005); IBM-i käive kvartaalselt. Vt. ka lk.13: IBM püstitas patentide rekordi

The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly.

Science.gov (United States)

Martinez, Natalia J; Chang, Hao-Ming; Borrajo, Jacob de Riba; Gregory, Richard I

2013-11-01

Argonaute2 (Ago2) protein and associated microRNAs (miRNAs) or small interfering RNAs (siRNAs) form the RNA-induced silencing complex (RISC) for target messenger RNA cleavage and post-transcriptional gene silencing. Although Ago2 is essential for RISC activity, the mechanism of RISC assembly is not well understood, and factors controlling Ago2 protein expression are largely unknown. A role for the Hsc70/Hsp90 chaperone complex in loading small RNA duplexes into the RISC has been demonstrated in cell extracts, and unloaded Ago2 is unstable and degraded by the lysosome in mammalian cells. Here we identify the co-chaperones Fkbp4 and Fkbp5 as Ago2-associated proteins in mouse embryonic stem cells. Pharmacological inhibition of this interaction using FK506 or siRNA-mediated Fkbp4/5 depletion leads to decreased Ago2 protein levels. We find FK506 treatment inhibits, whereas Fkbp4/5 overexpression promotes, miRNA-mediated stabilization of Ago2 expression. Simultaneous treatment with a lysosome inhibitor revealed the accumulation of unloaded Ago2 complexes in FK506-treated cells. We find that, consistent with unloaded miRNAs being unstable, FK506 treatment also affects miRNA abundance, particularly nascent miRNAs. Our results support a role for Fkbp4/5 in RISC assembly.

TAF11 assembles RISC loading complex to enhance RNAi efficiency

Science.gov (United States)

Liang, Chunyang; Wang, Yibing; Murota, Yukiko; Liu, Xiang; Smith, Dean; Siomi, Mikiko C.; Liu, Qinghua

2015-01-01

SUMMARY Assembly of the RNA-induced silencing complex (RISC) requires formation of the RISC loading complex (RLC), which contains Dicer-2(Dcr-2)-R2D2 complex and recruits duplex siRNA to Ago2 in Drosophila melanogaster. However, the precise composition and action mechanism of Drosophila RLC remain unclear. Here, we identified the missing factor of RLC as TATA-binding protein associated factor 11 (TAF11) by genetic screen. Although an annotated nuclear transcription factor, we found that TAF11 also associated with Dcr-2/R2D2 and localized to cytoplasmic D2 bodies. Consistent with defective RLC assembly in taf11−/− ovary extract, we reconstituted the RLC in vitro using recombinant Dcr-2-R2D2 complex, TAF11, and duplex siRNA. Furthermore, we showed that TAF11 tetramer facilitates Dcr-2-R2D2 tetramerization to enhance siRNA binding and RISC loading activities. Together, our genetic and biochemical studies define the molecular nature of Drosophila RLC and elucidate a novel cytoplasmic function of TAF11 in organizing RLC assembly to enhance RNAi efficiency. PMID:26257286

Spanish validation of the 10-item Connor-Davidson Resilience Scale (CD-RISC 10) with non-professional caregivers.

Science.gov (United States)

Blanco, Vanessa; Guisande, María Adelina; Sánchez, María Teresa; Otero, Patricia; Vázquez, Fernando L

2017-11-08

Despite the importance of resilience in populations under stress, and the fact that the 10-item version Connor-Davidson Resilience Scale (CD-RISC 10) is the shortest instrument for reliable and valid evaluation of resilience, there are no data on their psychometric properties in non-professional caregivers. The aim of this study was to analyze the psychometric properties and factorial structure of the spanish version of the CD-RISC 10 in non-professional caregivers. Independently trained assessors evaluated resilience, self-esteem, social support, emotional distress and depression in a sample of 294 caregivers (89.8% women, mean age 55.3 years). The internal consistency of CD-RISC 10 was α = .86. A single factor was found that accounted for 44.7% of the total variance. Confirmatory factor analysis corroborated this unifactorial model. The CD-RISC 10 was significantly correlated with the self-esteem (r = .416, p caregivers with depression (sensitivity = 70.0%, specificity = 68.2%). The CD-RISC 10 is a reliable and valid instrument to evaluate resilience in the caregiver population.

CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (IBM PC VERSION)

Science.gov (United States)

Riley, G.

1994-01-01

The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

IBM SmartCloud essentials

CERN Document Server

Schouten, Edwin

2013-01-01

A practical, user-friendly guide that provides an introduction to cloud computing using IBM SmartCloud, along with a thorough understanding of resource management in a cloud environment.This book is great for anyone who wants to get a grasp of what cloud computing is and what IBM SmartCloud has to offer. If you are an IT specialist, IT architect, system administrator, or a developer who wants to thoroughly understand the cloud computing resource model, this book is ideal for you. No prior knowledge of cloud computing is expected.

Kasiinomeistri Playtechi omanikud müüvad aktsiaid 240 miljoni dollari eest

Index Scriptorium Estoniae

2006-01-01

Iisraeli ärilehe Globes andmeil müüvad internetikasiinode arendamise ja haldamisega tegeleva Playtechi omanikud esmase avaliku müügi käigus aktsiaid 240 milj. USA dollari eest. Lisa: Kasumlik äritegevus

Anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), SOD or catalase on antimycin A-induced HeLa cell death.

Science.gov (United States)

Han, Yong Hwan; Kim, Suhn Hee; Kim, Sung Zoo; Park, Woo Hyun

2009-01-01

Antimycin A (AMA) is an inhibitor of the electron transport chain in mitochondria. In this study, we investigated the anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), superoxide dismutase (SOD) or catalase on AMA-induced HeLa cell death in relation to the cell cycle. Treatment with Z-VAD, SOD or catalase rescued some HeLa cells from AMA-induced apoptosis, but did not prevent the growth inhibition of HeLa cells by AMA. DNA flow cytometric analysis indicated that treatment with AMA significantly induced an S-phase arrest of the cell cycle at 72 h. Interestingly, Z-VAD, SOD and catalase intensified S-phase arrest in AMA-treated cells. In conclusion, treatment with Z-VAD, SOD or catalase decreased apoptotic levels in AMA-treated cells, which was associated with the enhancement of the S-phase arrest of the cell cycle in these cells.

TAF11 Assembles the RISC Loading Complex to Enhance RNAi Efficiency.

Science.gov (United States)

Liang, Chunyang; Wang, Yibing; Murota, Yukiko; Liu, Xiang; Smith, Dean; Siomi, Mikiko C; Liu, Qinghua

2015-09-03

Assembly of the RNA-induced silencing complex (RISC) requires formation of the RISC loading complex (RLC), which contains the Dicer-2 (Dcr-2)-R2D2 complex and recruits duplex siRNA to Ago2 in Drosophila melanogaster. However, the precise composition and action mechanism of Drosophila RLC remain unclear. Here we identified the missing factor of RLC as TATA-binding protein-associated factor 11 (TAF11) by genetic screen. Although it is an annotated nuclear transcription factor, we found that TAF11 also associated with Dcr-2/R2D2 and localized to cytoplasmic D2 bodies. Consistent with defective RLC assembly in taf11(-/-) ovary extract, we reconstituted the RLC in vitro using the recombinant Dcr-2-R2D2 complex, TAF11, and duplex siRNA. Furthermore, we showed that TAF11 tetramer facilitates Dcr-2-R2D2 tetramerization to enhance siRNA binding and RISC loading activities. Together, our genetic and biochemical studies define the molecular nature of the Drosophila RLC and elucidate a cytoplasmic function of TAF11 in organizing RLC assembly to enhance RNAi efficiency. Copyright © 2015 Elsevier Inc. All rights reserved.

Optimization of Particle-in-Cell Codes on RISC Processors

Science.gov (United States)

Decyk, Viktor K.; Karmesin, Steve Roy; Boer, Aeint de; Liewer, Paulette C.

1996-01-01

General strategies are developed to optimize particle-cell-codes written in Fortran for RISC processors which are commonly used on massively parallel computers. These strategies include data reorganization to improve cache utilization and code reorganization to improve efficiency of arithmetic pipelines.

IBM PC enhances the world's future

Science.gov (United States)

Cox, Jozelle

1988-01-01

Although the purpose of this research is to illustrate the importance of computers to the public, particularly the IBM PC, present examinations will include computers developed before the IBM PC was brought into use. IBM, as well as other computing facilities, began serving the public years ago, and is continuing to find ways to enhance the existence of man. With new developments in supercomputers like the Cray-2, and the recent advances in artificial intelligence programming, the human race is gaining knowledge at a rapid pace. All have benefited from the development of computers in the world; not only have they brought new assets to life, but have made life more and more of a challenge everyday.

Isospin invariant forms of interacting boson model (IBM)

International Nuclear Information System (INIS)

Evans, A.

1989-01-01

In the original version of the interacting boson model, IBM1, there are only two quantum numbers with exact values: the angular momentum and the number of bosons. IBM2 distinguishes between two kinds of bosons. However, the IBM2 algebra does not include the operators T± and consequently the states in the model have no good isospin, generally. IBM3 includes the isospin in the algebra and therefore the construction of states with any number of bosons and good isospin presents no problem. In this work, IBM3 is compared with the shell model. IBFM3 is also studied, which describes an odd nucleus as a system of N bosons plus a single nucleon that is a neutron with some probability and a proton with the complementary probability. The spectra obtained in the shell model, IBFM3 and IBFM2 for 45 Ti and 45 Sc are compared. (Author) [es

IBM 3380 E

CERN Multimedia

1985-01-01

In 1985 IBM announced a double density version. The Extended Capability Models of the 3380 (3380 E) having 5.04 gigabytes per chassis, that is, two 1.26 gigabyte actuators on two hard disk assemblies in one chassis.

Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination.

Science.gov (United States)

Lewkowicz, Przemysław; Cwiklińska, Hanna; Mycko, Marcin P; Cichalewska, Maria; Domowicz, Małgorzata; Lewkowicz, Natalia; Jurewicz, Anna; Selmaj, Krzysztof W

2015-05-13

MicroRNAs (miRNAs) associate with Argonaute (Ago), GW182, and FXR1 proteins to form RNA-induced silencing complexes (RISCs). RISCs represent a critical checkpoint in the regulation and bioavailability of miRNAs. Recent studies have revealed dysregulation of miRNAs in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE); however, the function of RISCs in EAE and MS is largely unknown. Here, we examined the expression of Ago, GW182, and FXR1 in CNS tissue, oligodendrocytes (OLs), brain-infiltrating T lymphocytes, and CD3(+)splenocytes (SCs) of EAE mic, and found that global RISC protein levels were significantly dysregulated. Specifically, Ago2 and FXR1 levels were decreased in OLs and brain-infiltrating T cells in EAE mice. Accordingly, assembly of Ago2/GW182/FXR1 complexes in EAE brain tissues was disrupted, as confirmed by immunoprecipitation experiments. In parallel with alterations in RISC complex content in OLs, we found downregulation of miRNAs essential for differentiation and survival of OLs and myelin synthesis. In brain-infiltrating T lymphocytes, aberrant RISC formation contributed to miRNA-dependent proinflammatory helper T-cell polarization. In CD3(+) SCs, we found increased expression of both Ago2 and FXR1 in EAE compared with nonimmunized mice. Therefore, our results demonstrate a gradient in expression of miRNA between primary activated T cells in the periphery and polarized CNS-infiltrating T cells. These results suggest that, in polarized autoreactive effector T cells, miRNA synthesis is inhibited in response to dysregulated RISC assembly, allowing these cells to maintain a highly specific proinflammatory program. Therefore, our findings may provide a mechanism that leads to miRNA dysregulation in EAE/MS. Copyright © 2015 the authors 0270-6474/15/357521-17$15.00/0.

Design of RISC Processor Using VHDL and Cadence

Science.gov (United States)

Moslehpour, Saeid; Puliroju, Chandrasekhar; Abu-Aisheh, Akram

The project deals about development of a basic RISC processor. The processor is designed with basic architecture consisting of internal modules like clock generator, memory, program counter, instruction register, accumulator, arithmetic and logic unit and decoder. This processor is mainly used for simple general purpose like arithmetic operations and which can be further developed for general purpose processor by increasing the size of the instruction register. The processor is designed in VHDL by using Xilinx 8.1i version. The present project also serves as an application of the knowledge gained from past studies of the PSPICE program. The study will show how PSPICE can be used to simplify massive complex circuits designed in VHDL Synthesis. The purpose of the project is to explore the designed RISC model piece by piece, examine and understand the Input/ Output pins, and to show how the VHDL synthesis code can be converted to a simplified PSPICE model. The project will also serve as a collection of various research materials about the pieces of the circuit.

The Use of Fluid Mechanics to Predict Regions of Microscopic Thrombus Formation in Pulsatile VADs.

Science.gov (United States)

Topper, Stephen R; Navitsky, Michael A; Medvitz, Richard B; Paterson, Eric G; Siedlecki, Christopher A; Slattery, Margaret J; Deutsch, Steven; Rosenberg, Gerson; Manning, Keefe B

2014-03-01

We compare the velocity and shear obtained from particle image velocimetry (PIV) and computational fluid dynamics (CFD) in a pulsatile ventricular assist device (VAD) to further test our thrombus predictive methodology using microscopy data from an explanted VAD. To mimic physiological conditions in vitro , a mock circulatory loop is used with a blood analog that matched blood's viscoelastic behavior at 40% hematocrit. Under normal physiologic pressures and for a heart rate of 75 bpm, PIV data is acquired and wall shear maps are produced. The resolution of the PIV shear rate calculations are tested using the CFD and found to be in the same range. A bovine study, using a model of the 50 cc Penn State V-2 VAD, for 30 days at a constant beat rate of 75 beats per minute (bpm) provides the microscopic data whereby after the 30 days, the device is explanted and the sac surface analyzed using scanning electron microscopy (SEM) and, after immunofluorescent labeling for platelets and fibrin, confocal microscopy. Areas are examined based on PIV measurements and CFD, with special attention to low shear regions where platelet and fibrin deposition are most likely to occur. Data collected within the outlet port in a direction normal to the front wall of the VAD shows that some regions experience wall shear rates less than 500 s -1 , which increases the likelihood of platelet and fibrin deposition. Despite only one animal study, correlations between PIV, CFD, and in vivo data show promise. Deposition probability is quantified by the thrombus susceptibility potential, a calculation to correlate low shear and time of shear with deposition.

The Resilient Schools Consortium (RiSC): Linking Climate Literacy, Resilience Thinking and Service Learning

Science.gov (United States)

Branco, B. F.; Fano, E.; Adams, J.; Shon, L.; Zimmermann, A.; Sioux, H.; Gillis, A.

2017-12-01

Public schools and youth voices are largely absent from climate resilience planning and projects in New York City. Additionally, research shows that U.S. science teachers' understanding of climate science is lacking, hence there is not only an urgent need to train and support teachers on both the science and pedagogy of climate change, but to link climate literacy, resilience thinking and service learning in K-12 education. However, research on participation of students and teachers in authentic, civic-oriented experiences points to increased engagement and learning outcomes in science. The Resilient Schools Consortium (RiSC) Project will address all these needs through an afterschool program in six coastal Brooklyn schools that engages teachers and urban youth (grades 6-12), in school and community climate resilience assessment and project design. The RiSC climate curriculum, co-designed by New York City school teachers with Brooklyn College, the National Wildlife Federation, New York Sea Grant and the Science and Resilience Institute at Jamaica Bay, will begin by helping students to understand the difference between climate and weather. The curriculum makes extensive use of existing resources such as NOAA's Digital Coast and the Coastal Resilience Mapping Portal. Through a series of four modules over two school years, the six RiSC teams will; 1. explore and understand the human-induced drivers of climate change and, particularly, the significant climate and extreme weather related risks to their schools and surrounding communities; 2. complete a climate vulnerability assessment within the school and the community that is aligned to OneNYC - the city's resilience planning document; 3. design and execute a school-based resilience project; and 4. propose resilience guidelines for NYC Department of Education schools. At the end of each school year, the six RiSC teams will convene a RiSC summit with city officials and resilience practitioners to share ideas and

EGS4 benchmark program

International Nuclear Information System (INIS)

Yasu, Y.; Hirayama, H.; Namito, Y.; Yashiro, S.

1995-01-01

This paper proposes EGS4 Benchmark Suite which consists of three programs called UCSAMPL4, UCSAMPL4I and XYZDOS. This paper also evaluates optimization methods of recent RISC/UNIX systems, such as IBM, HP, DEC, Hitachi and Fujitsu, for the benchmark suite. When particular compiler option and math library were included in the evaluation process, system performed significantly better. Observed performance of some of the RISC/UNIX systems were beyond some so-called Mainframes of IBM, Hitachi or Fujitsu. The computer performance of EGS4 Code System on an HP9000/735 (99MHz) was defined to be the unit of EGS4 Unit. The EGS4 Benchmark Suite also run on various PCs such as Pentiums, i486 and DEC alpha and so forth. The performance of recent fast PCs reaches that of recent RISC/UNIX systems. The benchmark programs have been evaluated with correlation of industry benchmark programs, namely, SPECmark. (author)

Lenovo acquires IBM's x86 low-end server business

Directory of Open Access Journals (Sweden)

Singh Pal Netra

2015-01-01

Full Text Available This paper presents an analysis of the key events, impacts and issues of Lenovo buying IBM's x86 low-end server business. The analysis include (i approval of the deal by regulatory bodies in the United States, Canada, India and China, (ii security concerns of US government departments, (iii pricing of the deals, (iv possible impact on IBM in future, and (v possibilities of Lenovo making it repeat of acquiring ThinkPad business of IBM. The paper presents analysis of qualitative and time series quantitative data. The qualitative data are mainly consists of different events before and after the acquisition of x86 server IBM business by Lenovo. The quantitative data are analyzed with respect to growth parameters of overall server business and Lenovo server business. Research paper also attempts to find out answer to specific 9 research questions with respect to impact on eco-systems of IBM and Lenovo. Based on analysis, it is inferred that IBM is not able to manage its traditional & well accepted products business in the face of fierce competition & low demand but Lenovo will manage. The deal was a financial necessity for IBM and strategic expansion in to new markets strategy for Lenovo.

[IBM Work and Personal Life Balance Programs.

Science.gov (United States)

International Business Machines Corp., Armonk, NY.

These five brochures describe the IBM Corporation's policies, programs, and initiatives designed to meet the needs of employees' child care and family responsibilities as they move through various stages of employment with IBM. The Work and Personal Life Balance Programs brochure outlines (1) policies for flexible work schedules, including…

Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9).

Science.gov (United States)

Fu, Qinqin; Yuan, Y Adam

2013-03-01

Intensive research interest has focused on small RNA-processing machinery and the RNA-induced silencing complex (RISC), key cellular machines in RNAi pathways. However, the structural mechanism regarding RISC assembly, the primary step linking small RNA processing and RNA-mediated gene silencing, is largely unknown. Human RNA helicase A (DHX9) was reported to function as an RISC-loading factor, and such function is mediated mainly by its dsRNA-binding domains (dsRBDs). Here, we report the crystal structures of human RNA helicase A (RHA) dsRBD1 and dsRBD2 domains in complex with dsRNAs, respectively. Structural analysis not only reveals higher siRNA duplex-binding affinity displayed by dsRBD1, but also identifies a crystallographic dsRBD1 pair of physiological significance in cooperatively recognizing dsRNAs. Structural observations are further validated by isothermal titration calorimetric (ITC) assay. Moreover, co-immunoprecipitation (co-IP) assay coupled with mutagenesis demonstrated that both dsRBDs are required for RISC association, and such association is mediated by dsRNA. Hence, our structural and functional efforts have revealed a potential working model for siRNA recognition by RHA tandem dsRBDs, and together they provide direct structural insights into RISC assembly facilitated by RHA.

Simty: generalized SIMT execution on RISC-V

OpenAIRE

Collange , Sylvain

2017-01-01

International audience; We present Simty, a massively multi-threaded RISC-V processor core that acts as a proof of concept for dynamic inter-thread vector-ization at the micro-architecture level. Simty runs groups of scalar threads executing SPMD code in lockstep, and assembles SIMD instructions dynamically across threads. Unlike existing SIMD or SIMT processors like GPUs or vector processors, Simty vector-izes scalar general-purpose binaries. It does not involve any instruction set extension...

Schizotypal Estimators in Adolescence: The Concurrent Validity of the RISC.

Science.gov (United States)

Rust, John; Chiu, Herbert

1988-01-01

Administered Minnesota Counseling Inventory and Rust Inventory of Schizotypal Cognition (RISC) to 174 adolescents in Hong Kong. Results showed that negative schizophrenic symptoms of social dysfunction and emotional instability as measured by Minnesota Counseling Inventory were positively and significantly correlated with positive schizotypal…

CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (IBM PC VERSION WITH CLIPSITS)

Science.gov (United States)

Riley, , .

1994-01-01

The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs.

Science.gov (United States)

Vickers, Timothy A; Crooke, Stanley T

2012-07-01

While most siRNAs induce sequence-specific target mRNA cleavage and degradation in a process mediated by Ago2/RNA-induced silencing complex (RISC), certain siRNAs have also been demonstrated to direct target RNA reduction through deadenylation and subsequent degradation of target transcripts in a process which involves Ago1/RISC and P-bodies. In the current study, we present data suggesting that a third class of siRNA exist, which are capable of promoting target RNA reduction that is independent of both Ago and RISC. These siRNAs bind the target messenger RNA at the polyA signal and are capable of redirecting a small amount of polyadenylation to downstream polyA sites when present, however, the majority of the activity appears to be due to inhibition of polyadenylation or deadenylation of the transcript, followed by exosomal degradation of the immature mRNA.

Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes.

Science.gov (United States)

Iwasaki, Shintaro; Kobayashi, Maki; Yoda, Mayuko; Sakaguchi, Yuriko; Katsuma, Susumu; Suzuki, Tsutomu; Tomari, Yukihide

2010-07-30

Small silencing RNAs--small interfering RNAs (siRNAs) or microRNAs (miRNAs)--direct posttranscriptional gene silencing of their mRNA targets as guides for the RNA-induced silencing complex (RISC). Both siRNAs and miRNAs are born double stranded. Surprisingly, loading these small RNA duplexes into Argonaute proteins, the core components of RISC, requires ATP, whereas separating the two small RNA strands within Argonaute does not. Here we show that the Hsc70/Hsp90 chaperone machinery is required to load small RNA duplexes into Argonaute proteins, but not for subsequent strand separation or target cleavage. We envision that the chaperone machinery uses ATP and mediates a conformational opening of Ago proteins so that they can receive bulky small RNA duplexes. Our data suggest that the chaperone machinery may serve as the driving force for the RISC assembly pathway. Copyright 2010 Elsevier Inc. All rights reserved.

A RISC/UNIX workstation second stage trigger

International Nuclear Information System (INIS)

Foreman, W.M.; Amann, J.F.; Fu, S.; Kozlowski, T.; Naivar, F.J.; Oothoudt, M.A.; Shelley, F.

1992-01-01

Recent advances in Reduced Instruction Set Computer (RISC) workstations have greatly altered the economics of processing power available for experiments. In addition VME interfaces available for many of these workstations make it possible to use them in experiment frontends for filtering and compressing data. Such a second stage trigger has been implemented at LAMPF using a commercially available workstation and VME interface. The implementation is described and measurements of data transfer speeds are presented in this paper

RISC & DSP System Application Design using VHDL

OpenAIRE

Rachana Solanki; Vinay Gupta

2014-01-01

The Reduced Instruction Set Computer (RISC) processor use fewer instructions with simple constructs, therefore they can be executed much faster within the CPU without having to use memory as often. It reduce execution time by simplifying the instruction set of the computer. The DSP processors are perform the operation such as Discrete Cosine transform (DCT), Inverse DCT, Discrete Fourier Transform (DFT) and Fast Fourier Transform (FFT) are performed by DSP system. This paper represent the des...

Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells.

Science.gov (United States)

Ohrt, Thomas; Mütze, Jörg; Staroske, Wolfgang; Weinmann, Lasse; Höck, Julia; Crell, Karin; Meister, Gunter; Schwille, Petra

2008-11-01

Studies of RNA interference (RNAi) provide evidence that in addition to the well-characterized cytoplasmic mechanisms, nuclear mechanisms also exist. The mechanism by which the nuclear RNA-induced silencing complex (RISC) is formed in mammalian cells, as well as the relationship between the RNA silencing pathways in nuclear and cytoplasmic compartments is still unknown. Here we show by applying fluorescence correlation and cross-correlation spectroscopy (FCS/FCCS) in vivo that two distinct RISC exist: a large approximately 3 MDa complex in the cytoplasm and a 20-fold smaller complex of approximately 158 kDa in the nucleus. We further show that nuclear RISC, consisting only of Ago2 and a short RNA, is loaded in the cytoplasm and imported into the nucleus. The loaded RISC accumulates in the nucleus depending on the presence of a target, based on an miRNA-like interaction with impaired cleavage of the cognate RNA. Together, these results suggest a new RISC shuttling mechanism between nucleus and cytoplasm ensuring concomitant gene regulation by small RNAs in both compartments.

Vadītāja darbība izglītības iestādes demokrātiskas vides veidošnā.

OpenAIRE

Ķepule, Inga

2009-01-01

Maģistra darba temats „Vadītāja darbība izglītības iestādes demokrātiskas vides veidošanā”. Zinātniskais vadītājs: Profesors, Dr. Phys., Andris Grīnfelds. Maģistra darba mērķis ir izstrādāt priekšlikums vadītāja efektīvai darbībai demokrātiskas vides aspektā. Maģistra darbā ir raksturoti teorētiskie aspekti par iestādes demokrātiskas vides jēdzienu, ietverot visus ietekmējošos faktorus, kā vadības stilu, motivāciju, un citus elementus. Maģistra darbā veiktā pētījuma rezultātā ir i...

Bodipy-VAD-Fmk, a useful tool to study yeast peptide N-glycanase activity

NARCIS (Netherlands)

Witte, Martin D.; Descals, Carlos V.; Lavoir, Sebastiaan V.P. de; Florea, Bogdan I.; Marel, Gijsbert A. van der; Overkleeft, Herman S.

2007-01-01

In this paper the development of a fluorescent activity based probe, Bodipy-VAD-Fmk, for visualization of yeast peptide N-glycanase is described. The activity based probe is used to assess the efficacy of known and new chitobiose-based electrophilic traps to bind yeast peptide N-glycanase.

Miks IBM müüb kroonijuveeli? / Valdo Randpere

Index Scriptorium Estoniae

Randpere, Valdo, 1958-

2004-01-01

Kuna konkurents on väga tihe, siis IBM loobub väikese marginaaliga personaalarvutite ärist ning keskendub serveritele ja keerukatele ärilahendustele. Lisa: IBM müüb personaalarvutite divisjoni hiinlastele

Uporaba orodja poslovne inteligence IBM Watson za predvidevanje prodaje

OpenAIRE

Stojić, Igor

2016-01-01

Diplomska naloga obravnava uporabo orodja IBM Watson in njegovo poslovno vrednost, ki jo ima v okviru oblikovanja napovedi prihodnje prodaje produktov. V teoretičnem delu podrobneje opredeljuje napovedovanje in smoter le-tega. V okviru empiričnega dela pa je bila izvedena primerjava uporabe ERP sistemov SAP in IBM Watson, pri čemer je bil dosledno prikazan postopek oblikovanja napovedi, tako s SAP kot tudi z IBM Watson, s slednjim pa tudi identificiran parameter, ki vpliva na prodajo nekateri...

Vadīšanas funkciju izpildes analīze Viļakas novada pašvaldībā.

OpenAIRE

Cibule, Rūta

2016-01-01

Bakalaura darba tēma ir “Vadīšanas funkciju izpildes analīze Viļakas novada pašvaldībā”. Darbā ir apskatītas vadīšanas funkcijas – organizēšana, plānošana, motivēšana, koordinēšana un kontrole, fokusējoties uz pirmajām trim minētajām. Bakalaura darba mērķis ir izanalizēt vadīšanas funkciju izpildi Viļakas novada domes administrācijā, pievēršot pastiprinātu uzmanību organizēšanai, motivēšanai un plānošanai. Lai šo mērķi izpildītu, pirmajā daļā autore izpētīja dažādus teorijas avotus, otrajā da...

SIA "Baltegle" naudas plūsmas analīze un vadīšana

OpenAIRE

Jegorova, Valērija

2011-01-01

Vairākiem Latvijas uzņēmumiem ir aktuālas stabilizēšanas problēmas, kuras ietekmēja naudas plūsmas neefektīva vadīšana. Diplomdarba mērķis ir novērtēt SIA „Baltegle” naudas plūsmu un izstrādāt priekšlikumus tās optimizācijai. Pirmajā diplomdarba nodaļā apskatīta naudas plūsmas būtība, otrajā nodaļā - naudas plūsmas pārskata sagatavošanas īpatnības, trešajā nodaļā - analīzes un vadīšanas aspekti. Ceturtajā nodaļā pētīta SIA „Baltegle” saimnieciskā darbība. Piektajā nodaļā veikta uzņēmuma...

Development of a data acquisition system using a RISC/UNIXTM workstation

International Nuclear Information System (INIS)

Takeuchi, Y.; Tanimori, T.; Yasu, Y.

1993-01-01

We have developed a compact data acquisition system on RISC/UNIX workstations. A SUN TM SPARCstation TM IPC was used, in which an extension bus 'SBus TM ' was linked to a VMEbus. The transfer rate achieved was better than 7 Mbyte/s between the VMEbus and the SUN. A device driver for CAMAC was developed in order to realize an interruptive feature in UNIX. In addition, list processing has been incorporated in order to keep the high priority of the data handling process in UNIX. The successful developments of both device driver and list processing have made it possible to realize the good real-time feature on the RISC/UNIX system. Based on this architecture, a portable and versatile data taking system has been developed, which consists of a graphical user interface, I/O handler, user analysis process, process manager and a CAMAC device driver. (orig.)

RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators.

Science.gov (United States)

Redfern, Andrew D; Colley, Shane M; Beveridge, Dianne J; Ikeda, Naoya; Epis, Michael R; Li, Xia; Foulds, Charles E; Stuart, Lisa M; Barker, Andrew; Russell, Victoria J; Ramsay, Kerry; Kobelke, Simon J; Li, Xiaotao; Hatchell, Esme C; Payne, Christine; Giles, Keith M; Messineo, Adriana; Gatignol, Anne; Lanz, Rainer B; O'Malley, Bert W; Leedman, Peter J

2013-04-16

The cytoplasmic RNA-induced silencing complex (RISC) contains dsRNA binding proteins, including protein kinase RNA activator (PACT), transactivation response RNA binding protein (TRBP), and Dicer, that process pre-microRNAs into mature microRNAs (miRNAs) that target specific mRNA species for regulation. There is increasing evidence for important functional interactions between the miRNA and nuclear receptor (NR) signaling networks, with recent data showing that estrogen, acting through the estrogen receptor, can modulate initial aspects of nuclear miRNA processing. Here, we show that the cytoplasmic RISC proteins PACT, TRBP, and Dicer are steroid receptor RNA activator (SRA) binding NR coregulators that target steroid-responsive promoters and regulate NR activity and downstream gene expression. Furthermore, each of the RISC proteins, together with Argonaute 2, associates with SRA and specific pre-microRNAs in both the nucleus and cytoplasm, providing evidence for links between NR-mediated transcription and some of the factors involved in miRNA processing.

Competition between alliance blocks : the case of the RISC microprocessor technology

NARCIS (Netherlands)

Vanhaverbeke, W.P.M.; Noorderhaven, N.G.

2001-01-01

Competition between alliance blocks is a new form of rivalry: groups of firms link together for a common purpose by means of strategic alliances, and competition between alliance blocks is superimposed on competition between individual firms. This paper focuses on alliance blocks in the RISC

IBM PC/IX operating system evaluation plan

Science.gov (United States)

Dominick, Wayne D. (Editor); Granier, Martin; Hall, Philip P.; Triantafyllopoulos, Spiros

1984-01-01

An evaluation plan for the IBM PC/IX Operating System designed for IBM PC/XT computers is discussed. The evaluation plan covers the areas of performance measurement and evaluation, software facilities available, man-machine interface considerations, networking, and the suitability of PC/IX as a development environment within the University of Southwestern Louisiana NASA PC Research and Development project. In order to compare and evaluate the PC/IX system, comparisons with other available UNIX-based systems are also included.

Structural insights into RNA processing by the human RISC-loading complex.

Science.gov (United States)

Wang, Hong-Wei; Noland, Cameron; Siridechadilok, Bunpote; Taylor, David W; Ma, Enbo; Felderer, Karin; Doudna, Jennifer A; Nogales, Eva

2009-11-01

Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC). In humans, Argonaute2 (AGO2) assembles with the guide RNA-generating enzyme Dicer and the RNA-binding protein TRBP to form a RISC-loading complex (RLC), which is necessary for efficient transfer of nascent siRNAs and miRNAs from Dicer to AGO2. Here, using single-particle EM analysis, we show that human Dicer has an L-shaped structure. The RLC Dicer's N-terminal DExH/D domain, located in a short 'base branch', interacts with TRBP, whereas its C-terminal catalytic domains in the main body are proximal to AGO2. A model generated by docking the available atomic structures of Dicer and Argonaute homologs into the RLC reconstruction suggests a mechanism for siRNA transfer from Dicer to AGO2.

Implementation of NASTRAN on the IBM/370 CMS operating system

Science.gov (United States)

Britten, S. S.; Schumacker, B.

1980-01-01

The NASA Structural Analysis (NASTRAN) computer program is operational on the IBM 360/370 series computers. While execution of NASTRAN has been described and implemented under the virtual storage operating systems of the IBM 370 models, the IBM 370/168 computer can also operate in a time-sharing mode under the virtual machine operating system using the Conversational Monitor System (CMS) subset. The changes required to make NASTRAN operational under the CMS operating system are described.

INIS information retrieval based on IBM's IRMS

International Nuclear Information System (INIS)

Gadjokov, V.; Schmid, H.; Del Bigio, G.

1975-01-01

An information retrieval system for the INIS data base is described. It allows for batch processing on an IBM/360 or /370 computer operated under OS or VS. The program package consists basically of IBM's IRMS system which was converted from DOS to OS and adapted for INIS requirements. Sections 1-9 present the system from the user's point of view, deliberately omitting all the programming details. Program descriptions with data set definitions and file formats are given in sections 10-12. (author)

Single-molecule fluorescence measurements reveal the reaction mechanisms of the core RISC, composed of human Argonaute 2 and a guide RNA.

Science.gov (United States)

Jo, Myung Hyun; Song, Ji-Joon; Hohng, Sungchul

2015-12-01

In eukaryotes, small RNAs play important roles in both gene regulation and resistance to viral infection. Argonaute proteins have been identified as a key component of the effector complexes of various RNA-silencing pathways, but the mechanistic roles of Argonaute proteins in these pathways are not clearly understood. To address this question, we performed single-molecule fluorescence experiments using an RNA-induced silencing complex (core-RISC) composed of a small RNA and human Argonaute 2. We found that target binding of core-RISC starts at the seed region of the guide RNA. After target binding, four distinct reactions followed: target cleavage, transient binding, stable binding, and Argonaute unloading. Target cleavage required extensive sequence complementarity and accelerated core-RISC dissociation for recycling. In contrast, the stable binding of core-RISC to target RNAs required seed-match only, suggesting a potential explanation for the seed-match rule of microRNA (miRNA) target selection.

Burden to importance ratio as a quantitative measure to validate the RISC-3 SSC in OPTION-2

International Nuclear Information System (INIS)

Ha, J. S.; Sung, P. H.

2004-01-01

A Risk-Informed Safety Significance Categorization (RISSC) is to categorize structures, systems, or components (SSCs) of a Nuclear Power Plant (NPP) into two or more groups, according to their safety significance using both probabilistic and deterministic insights. Recently, OPTION-2 (which is an emerging risk-informed paradigm) recommends that SSCs should be categorized into four groups according to whether they are safety-related or not as well as their safety significance. With the change of 10 CFR 50, safety-related components which categorized into low safety significant SSC (RISC-3 SSC) can be exempted from the existing conservative requirements. Consequently, as OPTION-2 paradigm is applied, a validation process focused on the RISC-3 SSC is needed to assure the categorization results, because most of existing RISSC methods focused on the categorization of the whole SSCs of NPPs based on importance measures obtained from probabilistic and deterministic insights. In this work, Burden to Importance Ratio (BIR) is utilized as a measure for the validation of RISC-3 SSC in OPTION-2. To demonstrate the usefulness of the proposed approach, the approach is applied to 22 components selected from 512 In-Service Test (IST) components of Ulchin unit 3. The results of the application show that the proposed approach is useful for the validation of RISC-3 SSC in OPTION-2

On IBM's Millennial Puzzle

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 10. On IBM's Millennial Puzzle. A Sarangarajan. Classroom Volume 5 Issue 10 October 2000 pp 81-89. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/005/10/0081-0089. Author Affiliations.

Ainult võltsid jäävad ellu = Only phonies will survive / Anders Härm

Index Scriptorium Estoniae

Härm, Anders, 1977-

2009-01-01

Punkansamblite tekkest Ameerikas ja Inglismaal, ansamblist "Sex pistols" ning pungi fenomenist, transgressioonist ja selle rituaalidest performance'ikunstis. Ka Von Krahli Teatris lavastatud etendusest "Ainult võltsid jäävad ellu", mis kajastab punkansambli Sex Pistols tekkelugu ja võtmestseene, lavastaja Marko Raat

Arabidopsis ARGONAUTE7 selects miR390 through multiple checkpoints during RISC assembly.

Science.gov (United States)

Endo, Yayoi; Iwakawa, Hiro-oki; Tomari, Yukihide

2013-07-01

Plant ARGONAUTE7 (AGO7) assembles RNA-induced silencing complex (RISC) specifically with miR390 and regulates the auxin-signalling pathway via production of TAS3 trans-acting siRNAs (tasiRNAs). However, how AGO7 discerns miR390 among other miRNAs remains unclear. Here, we show that the 5' adenosine of miR390 and the central region of miR390/miR390* duplex are critical for the specific interaction with AGO7. Furthermore, despite the existence of mismatches in the seed and central regions of the duplex, cleavage of the miR390* strand is required for maturation of AGO7-RISC. These findings suggest that AGO7 uses multiple checkpoints to select miR390, thereby circumventing promiscuous tasiRNA production.

RISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells.

Science.gov (United States)

Pandolfini, Luca; Luzi, Ettore; Bressan, Dario; Ucciferri, Nadia; Bertacchi, Michele; Brandi, Rossella; Rocchiccioli, Silvia; D'Onofrio, Mara; Cremisi, Federico

2016-05-06

Embryonic stem cells are intrinsically unstable and differentiate spontaneously if they are not shielded from external stimuli. Although the nature of such instability is still controversial, growing evidence suggests that protein translation control may play a crucial role. We performed an integrated analysis of RNA and proteins at the transition between naïve embryonic stem cells and cells primed to differentiate. During this transition, mRNAs coding for chromatin regulators are specifically released from translational inhibition mediated by RNA-induced silencing complex (RISC). This suggests that, prior to differentiation, the propensity of embryonic stem cells to change their epigenetic status is hampered by RNA interference. The expression of these chromatin regulators is reinstated following acute inactivation of RISC and it correlates with loss of stemness markers and activation of early cell differentiation markers in treated embryonic stem cells. We propose that RISC-mediated inhibition of specific sets of chromatin regulators is a primary mechanism for preserving embryonic stem cell pluripotency while inhibiting the onset of embryonic developmental programs.

"Oftast du vet själv vad är det rätta" : Högstadieelevers sociala mediavanor och regelperception i onlinesammanhang

OpenAIRE

Bergman, Mikael

2018-01-01

Sammanfattning: Sociala medier spelar en allt större roll i hur vi kommunicerar och uttrycker oss. Denna studie är ämnad att utveckla och koppla ihop den redan existerande forskningen om ungdomars sociala mediavanor på Snapchat och Instagram, och forskning om vad sociala mediaanvändare upplever vad man kan och får publicera på dessa sociala medier. Denna studie utforskar detta genom tre fokusgruppsintervjuer med 15 åriga niondeklassare. Resultatet analyseras genom dramaturgi som till stor del...

Personāla vadīšana Valsts ieņēmumu dienesta Rīgas muitas reģionālajā iestādē

OpenAIRE

Beinerte, Inga

2009-01-01

Lai veiksmīgi uzsāktu uzņēmuma vadīšanu ir nepieciešami noteikti resursi, uz ko balstīt uzņēmumu. Visneprognozējamākie un grūtāk vadāmie no šiem resursiem ir cilvēkresursi. Bez cilvēkresursiem nav iedomājama uzņēmējdarbība, jo tie izgudro un ražo preces, sniedz pakalpojumus, vada un kontrolē procesu darbību, kā arī kontrolē to kvalitāti. Maģistra darba „Personāla vadīšana Valsts ieņēmumu dienesta Rīgas muitas reģionālajā iestādē” mērķis ir izpētīt personāla vadību, tās būtību un izanalizē...

IBM, Elsevier Science, and academic freedom.

Science.gov (United States)

Bailar, John C; Cicolella, Andre; Harrison, Robert; LaDou, Joseph; Levy, Barry S; Rohm, Timothy; Teitelbaum, Daniel T; Wang, Yung-Der; Watterson, Andrew; Yoshida, Fumikazu

2007-01-01

Elsevier Science refused to publish a study of IBM workers that IBM sought to keep from public view. Occupational and environmental health (OEH) suffers from the absence of a level playing field on which science can thrive. Industry pays for a substantial portion of OEH research. Studies done by private consulting firms or academic institutions may be published if the results suit the sponsoring companies, or they may be censored. OEH journals often reflect the dominance of industry influence on research in the papers they publish, sometimes withdrawing or modifying papers in line with industry and advertising agendas. Although such practices are widely recognized, no fundamental change is supported by government and industry or by professional organizations.

Beyond the VAD: Human Factors Engineering for Mechanically Assisted Circulation in the 21st Century.

Science.gov (United States)

Throckmorton, Amy L; Patel-Raman, Sonna M; Fox, Carson S; Bass, Ellen J

2016-06-01

Thousands of ventricular assist devices (VADs) currently provide circulatory support to patients worldwide, and dozens of heart pump designs for adults and pediatric patients are under various stages of development in preparation for translation to clinical use. The successful bench-to-bedside development of a VAD involves a structured evaluation of possible system states, including human interaction with the device and auxiliary component usage in the hospital or home environment. In this study, we review the literature and present the current landscape of preclinical design and assessment, decision support tools and procedures, and patient-centered therapy. Gaps of knowledge are identified. The study findings support the need for more attention to user-centered design approaches for medical devices, such as mechanical circulatory assist systems, that specifically involve detailed qualitative and quantitative assessments of human-device interaction to mitigate risk and failure. Copyright © 2015 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Collective states of even Xe isotopes in IBM+MQRPA

Directory of Open Access Journals (Sweden)

Efimov A. D.

2016-01-01

Full Text Available A modification of the Quasiparticle Random Phase Approximation (QRPA with small ground state correlations is suggested. The lowest energy phonon is used as the image of d-boson of the Interacting Boson Model 1 (IBM1 and applied to microscopical calculations of the IBM1 parameters. Results are compared with experimental data for Xe isotopes.

Polerovirus protein P0 prevents the assembly of small RNA-containing RISC complexes and leads to degradation of ARGONAUTE1.

Science.gov (United States)

Csorba, Tibor; Lózsa, Rita; Hutvágner, György; Burgyán, József

2010-05-01

RNA silencing plays an important role in plants in defence against viruses. To overcome this defence, plant viruses encode suppressors of RNA silencing. The most common mode of silencing suppression is sequestration of double-stranded RNAs involved in the antiviral silencing pathways. Viral suppressors can also overcome silencing responses through protein-protein interaction. The poleroviral P0 silencing suppressor protein targets ARGONAUTE (AGO) proteins for degradation. AGO proteins are the core component of the RNA-induced silencing complex (RISC). We found that P0 does not interfere with the slicer activity of pre-programmed siRNA/miRNA containing AGO1, but prevents de novo formation of siRNA/miRNA containing AGO1. We show that the AGO1 protein is part of a high-molecular-weight complex, suggesting the existence of a multi-protein RISC in plants. We propose that P0 prevents RISC assembly by interacting with one of its protein components, thus inhibiting formation of siRNA/miRNA-RISC, and ultimately leading to AGO1 degradation. Our findings also suggest that siRNAs enhance the stability of co-expressed AGO1 in both the presence and absence of P0.

RISC mezzanines for controlling data acquisition in the NA48 experiment at CERN

International Nuclear Information System (INIS)

Guzik, Z.; Chlopik, A.; Bal, Fr.; Formenti, F.; Lacourt, A.

2000-01-01

A part of the LKr calorimeter data acquisition system of the NA48 experiment (a precision measurements of ε/ε' in CP violating; K 0 →2π decays) is described. The experiment runs on the SPS north area in CERN. This paper presents some aspects of controlling the NA48 readout process based on commercial RIO 8260 RISC processors, which were used as a core for maintaining control algorithms. Several RISC processors were equipped with custom-made VME mezzanine boards providing interfacing, pre-processing and data formatting. These mezzanines are subjects of this paper. They are: RIO-TIC/DAT - time stamp distributor and buffered DT-bus interface, FOL-RIO - optical data formatter and event merger and 'TAXI receiver' - handling trigger data of the NA48 Level 2 trigger supervisor. Also the interface between DT-bus and S-link/PCI is described

A fastbus master based on a risc microprocessor

International Nuclear Information System (INIS)

Cerrito, L.; Chorowicz, V.; Lebbolo, H.; Vallereau, A.

1990-01-01

SISIFUS is a general purpose Fastbus Master and Slave able to perform any operation on both Fastbus segments. Master operations are directed either by the processor or by two fast sequencers. A Block Mover function is implemented allowing direct data block transfers between two Slaves. SISIFUS uses the AM 29000 RISC microprocessor which can execute every assembler instruction in 40ns. The on-board monitor/debugger allows programs to be written in assembler from a terminal connected to the module or written in C and cross compiled on a host computer (PC)

Data Discovery with IBM Watson

Science.gov (United States)

Fessler, J.

2016-12-01

BM Watson is a cognitive computing system that uses machine learning, statistical analysis, and natural language processing to find and understand the clues in questions posed to it. Watson was made famous when it bested two champions on TV's Jeopardy! show. Since then, Watson has evolved into a platform of cognitive services that can be trained on very granular fields up study. Watson is being used to support a number of subject domains, such as cancer research, public safety, engineering, and the intelligence community. IBM will be providing a presentation and demonstration on the Watson technology and will discuss its capabilities including Natural Language Processing, text analytics and enterprise search, as well as cognitive computing with deep Q&A. The team will also be giving examples of how IBM Watson technology is being used to support real-world problems across a number of public sector agencies

IBM WebSphere Application Server 80 Administration Guide

CERN Document Server

Robinson, Steve

2011-01-01

IBM WebSphere Application Server 8.0 Administration Guide is a highly practical, example-driven tutorial. You will be introduced to WebSphere Application Server 8.0, and guided through configuration, deployment, and tuning for optimum performance. If you are an administrator who wants to get up and running with IBM WebSphere Application Server 8.0, then this book is not to be missed. Experience with WebSphere and Java would be an advantage, but is not essential.

The IBM i Programmer's Guide to PHP

CERN Document Server

Olen, Jeff

2012-01-01

This is the first book to comprehensively address PHP and how it can-and should-be deployed on the IBM i. With this IBM i-specific point of view, the authors examine how to transfer skills from a green screen environment to the Web, become intimately familiar with PHP's commonly used features, and help start down the road of highly interactive Web-based application development. For decades, the green screen has been the ubiquitous interface into an organization's data. But with the advent of HTML, the Internet, and the browser, combined with the end user's existing familiarity with the Web,

Flexible input, dazzling output with IBM i

CERN Document Server

Victória-Pereira, Rafael

2014-01-01

Link your IBM i system to the modern business server world! This book presents easier and more flexible ways to get data into your IBM i system, along with rather surprising methods to export and present the vital business data it contains. You'll learn how to automate file transfers, seamlessly connect PC applications with your RPG programs, and much more. Input operations will become more flexible and user-proof, with self-correcting import processes and direct file transfers that require a minimum of user intervention. Also learn novel ways to present information: your DB2 data will look gr

New Generation General Purpose Computer (GPC) compact IBM unit

Science.gov (United States)

1991-01-01

New Generation General Purpose Computer (GPC) compact IBM unit replaces a two-unit earlier generation computer. The new IBM unit is documented in table top views alone (S91-26867, S91-26868), with the onboard equipment it supports including the flight deck CRT screen and keypad (S91-26866), and next to the two earlier versions it replaces (S91-26869).

"Isa kuhu need värvid jäävad ..." : [luuletused] / Jaan Kaplinski

Index Scriptorium Estoniae

Kaplinski, Jaan, 1941-

2002-01-01

Sisu: "Isa kuhu need värvid jäävad ..." ; Lume ootamine ; "Oh sina paha peavalu ..." ; "Märg on vihmal märg on kastel ..." ; "Peet kisub peeti ..." ; "Küllap väikestel mustadel ..." ; "Mart haigutab ..." ; Kuu ; Teremees Tõnu ; Jalgrataste talveuni ; Kitsu ja kätsu ; Siret siret siterkuuti ; Suve soe silmadesse ; Iirimaal on ilmalapsed ; Miks ; Sügisel ; Täis ; Mis algab ; Aeg ; "Ma koiduajal ärkasin ..."

Klientu attiecību sociālās vadības ietekme uz klientu lojalitāti; sociālā tīkla Facebook piemērs

OpenAIRE

Avotiņa, Lelde

2015-01-01

Maģistra darba “Klientu attiecību sociālās vadības ietekme uz klientu lojalitāti; sociālā tīkla Facebook piemērs” mērķis ir noteikt un analizēt faktorus, kas ietekmē lojālo klientu piesaistīšanu un noturēšanu sociālo mediju vidē klientu attiecību sociālās vadības kontekstā. Maģistra darba pirmajā nodaļā tiek aplūkoti jautājumi, kas skar klientu lojalitāti, klientu attiecību vadību, klientu lomu sociālo mediju kontekstā un klientu attiecību sociālo vadību. Šī teorētiskā apkopojuma rezultātā...

IBM KELOMPOK USAHA SOUVENIR SABLON DIGITAL

Directory of Open Access Journals (Sweden)

Maria krisnawati

2015-12-01

Full Text Available Kegiatan IbM dilaksanakan pada kelompok souvenir sablon digital di Desa Sidodadi dan Karanglo Kecamatan Tawangnangu Kabupaten Karanganyar. Kegiatan ini bertujuan untuk: 1 meningkatkan motivasi wirausaha mitra; 2 meningkatkan pemahaman mitra tentang perencanaan bisnis dan manajemen usaha; 3 meningkatkan kemampuan SDM dalam teknik produksi dan pemasaran; serta 4 mengembangkan jejaring kewirausahaan pemuda untuk menopang pengembangan ekonomi kreatif. Target yang akan dicapai melalui IbM adalah pada aspek produksi dan manajemen. Aspek produksi, yaitu meningkatnya teknologi produksi pembuatan souvenir, meningkatnya kemampuan dalam bidang desain melalui program corel draw dan Adobe photoshop serta pemantapan prosedur produksi dengan memperhatikan kesehatan dan keselamatan kerja. Aspek manajemen, yaitu pada manajemen keuangan, mengadakan pengelolaaan keuangan yang baik dengan pembukuan yang teratur, melalui manajemen pemasaran menghasilkan bentuk-bentuk promosi melalui berbagai media, perluasan jaringan pasar dan mempermudah akses konsumen memesan produk. Melalui manajemen SDM dapat meningkatkan kemampuan SDM dengan pelatihan, pemberian motivasi wirausaha dan pemberdayaan diri.Kegiatan IbM dilaksanakan melalui tahapan 1 Tahap Persiapan; 2 Tahap Assesment; 3 Tahap Perencanaan Program atau Kegiatan; 4 Tahap Pemformulasian Rencana Aksi; 5 Tahap Pelaksanaan (Implementasi Program atau Kegiatan; serta 6 Tahap Evaluasi. Diharapkan melalui tahapan yang akan dilaksanakan dapat membantu menyelesaikan permasalahan dan memenuhi kebutuhan mitra.Kata kunci : IbM, pelatihan, pembinaan, pendampingan, souvenir, sablon digital.

RISC mezzanines for controlling data acquisition in the NA48 experiment at CERN

CERN Document Server

Guzik, Z; Bal, F; Formenti, F; Lacourt, A

2000-01-01

A part of the LKr calorimeter data acquisition system of the NA48 experiment (a precision measurements of epsilon / epsilon ' in CP- violating K/sup 0/ to 2 pi decays) is described. The experiment runs on the SPS north area in CERN. This paper presents some aspects of controlling the NA48 readout process based on commercial RIO 8260 RISC processors, which were used as a core for maintaining control algorithms. Several RISC processors were equipped with custom-made VME mezzanine boards providing interfacing, pre-processing and data formatting. These mezzanines are the subjects of this paper. They are: RIO-TIC/DAT (a time-stamp distributor and buffered DT-bus interface), FOL-RIO (an optical data formatter and event merger) and "TAXI receiver" (for handling trigger data of the NA48 Level-2 trigger supervisor). Also, the interface between the DT-bus and S- link/PCI is described. (8 refs).

IBM announces global Grid computing solutions for banking, financial markets

CERN Multimedia

2003-01-01

"IBM has announced a series of Grid projects around the world as part of its Grid computing program. They include IBM new Grid-based product offerings with business intelligence software provider SAS and other partners that address the computer-intensive needs of the banking and financial markets industry (1 page)."

RISC Processors and High Performance Computing

Science.gov (United States)

Bailey, David H.; Saini, Subhash; Craw, James M. (Technical Monitor)

1995-01-01

This tutorial will discuss the top five RISC microprocessors and the parallel systems in which they are used. It will provide a unique cross-machine comparison not available elsewhere. The effective performance of these processors will be compared by citing standard benchmarks in the context of real applications. The latest NAS Parallel Benchmarks, both absolute performance and performance per dollar, will be listed. The next generation of the NPB will be described. The tutorial will conclude with a discussion of future directions in the field. Technology Transfer Considerations: All of these computer systems are commercially available internationally. Information about these processors is available in the public domain, mostly from the vendors themselves. The NAS Parallel Benchmarks and their results have been previously approved numerous times for public release, beginning back in 1991.

Training in the Workplace: An IBM Case Study. Contractor Report.

Science.gov (United States)

Grubb, Ralph E.

International Business Machines Corporation's (IBM) efforts to develop a corporate culture are associated with its founder, Thomas J. Watson, Sr. From the start of his association with the company in 1914, the importance of education was stressed. The expansion of the education and training organization paralleled IBM's 75-year growth. In January…

The microelectronic and photonic test bed RISC processor and DRAM memory stack experiments

International Nuclear Information System (INIS)

Clark, K.A.; Meehan, T.J.

1999-01-01

This paper reports on the on-orbit data obtained from the MPTB RISC Processor Experiment, containing three Integrated Device Technologies R3081 processors. During operations, nine SEUs were observed in the processors, and four SEUs were observed in the memory and/or support circuitry. (authors)

BOAST II for the IBM 3090 and RISC 6000

Energy Technology Data Exchange (ETDEWEB)

Hebert, P.; Bourgoyne, A.T. Jr.; Tyler, J.

1993-05-01

BOAST II simulates isothermal, darcy flow in three dimensions. It assumes that reservoir liquids can be described in three fluid phases (oil, gas, and water) of constant composition, with physical properties that depend on pressure, only. These reservoir fluid approximations are acceptable for a large percentage of the world's oil and gas reservoirs. Consequently, BOAST II has a wide range of applicability. BOAST II can simulate oil and/or gas recovery by fluid expansion, displacement, gravity drainage, and capillary imbibition mechanisms. Typical field production problems that BOAST II can handle include primary depletion studies, pressure maintenance by water and/or gas injection, and evaluation of secondary recovery waterflooding and displacement operations. Technically, BOAST II is a finite, implicit pressure, explicit saturation (IMPES) numerical simulator. It applies both direct and iterative solution techniques for solving systems of algebraic equations. The well model allows specification of rate or pressure constraints on well performance, and the user is free to add or to recomplete wells during the simulation. In addition, the user can define multiple rock and PVT regions and can choose from three aquifer models. BOAST II also provides flexible initialization, a bubble-point tracking scheme, automatic time-step control, and a material balance check on solution stability. The user controls output, which includes a run summary and line-printer plots of fieldwide performance.

A general model of concurrency and its implementation as many-core dynamic RISC processors

NARCIS (Netherlands)

Bernard, T.; Bousias, K.; Guang, L.; Jesshope, C.R.; Lankamp, M.; van Tol, M.W.; Zhang, L.

2008-01-01

This paper presents a concurrent execution model and its micro-architecture based on in-order RISC processors, which schedules instructions from large pools of contextualised threads. The model admits a strategy for programming chip multiprocessors using parallelising compilers based on existing

RISC. A new style in the design of architectures

International Nuclear Information System (INIS)

Cortadella, J.; Gonzalez, A.; Llaberia, J.M.

1988-01-01

In the 80's a new architecture design and implementation style has appeared: the RISC style. It proposes an overall view of the system were the processor is included. For each function, an extensive analysis has to be performed in order to evaluate the advantages and disadvantages that hardware and software introduce in the design. An optimum design involved an agreement between both levels and has to take into account cost, performance, and technological factors. In this paper, the main features of this new architecture design style are presented. (Author)

Training IBM Watson using Automatically Generated Question-Answer Pairs

OpenAIRE

Lee, Jangho; Kim, Gyuwan; Yoo, Jaeyoon; Jung, Changwoo; Kim, Minseok; Yoon, Sungroh

2016-01-01

IBM Watson is a cognitive computing system capable of question answering in natural languages. It is believed that IBM Watson can understand large corpora and answer relevant questions more effectively than any other question-answering system currently available. To unleash the full power of Watson, however, we need to train its instance with a large number of well-prepared question-answer pairs. Obviously, manually generating such pairs in a large quantity is prohibitively time consuming and...

IBM SPSS Modeler cookbook

CERN Document Server

McCormick, Keith

2013-01-01

This is a practical cookbook with intermediate-advanced recipes for SPSS Modeler data analysts. It is loaded with step-by-step examples explaining the process followed by the experts.If you have had some hands-on experience with IBM SPSS Modeler and now want to go deeper and take more control over your data mining process, this is the guide for you. It is ideal for practitioners who want to break into advanced analytics.

Issues Identified During September 2016 IBM OpenMP 4.5 Hackathon

Energy Technology Data Exchange (ETDEWEB)

Richards, David F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2017-03-15

In September, 2016 IBM hosted an OpenMP 4.5 Hackathon at the TJ Watson Research Center. Teams from LLNL, ORNL, SNL, LANL, and LBNL attended the event. As with the 2015 hackathon, IBM produced an extremely useful and successful event with unmatched support from compiler team, applications staff, and facilities. Approximately 24 IBM staff supported 4-day hackathon and spent significant time 4-6 weeks out to prepare environment and become familiar with apps. This hackathon was also the first event to feature LLVM & XL C/C++ and Fortran compilers. This report records many of the issues encountered by the LLNL teams during the hackathon.

The IBM neutrino-mass experiment

International Nuclear Information System (INIS)

Clark, G.J.; Frisch, M.A.; Chaudhari, P.; Bregman, M.F.

1985-01-01

IBM is undertaking an experiment to measure the electron anti-neutrino mass. A high precision measurement of the tritium Β-decay spectrum near the end point is used to infer the neutrino mass. Electron energies are measured using a large spherical retarding grid analyzer. We are placing particular emphasis on understanding the complications introduced by solid state effects in the source

The IBM neutrino-mass experiment

International Nuclear Information System (INIS)

Clark, G.J.; Frisch, M.A.; Chaudhari, P.; Bregman, M.F.

1985-01-01

IBM is undertaking an experiment to measure the electron anti-neutrino mass. A high precision measurement of the tritium β-decay spectrum near the end point is used to infer the neutrino mass. Electron energies are measured using a large spherical retarding grid analyzer. They are placing particular emphasis on understanding the complications introduced by solid state effects in the source

Making IBM's Computer, Watson, Human

Science.gov (United States)

Rachlin, Howard

2012-01-01

This essay uses the recent victory of an IBM computer (Watson) in the TV game, "Jeopardy," to speculate on the abilities Watson would need, in addition to those it has, to be human. The essay's basic premise is that to be human is to behave as humans behave and to function in society as humans function. Alternatives to this premise are considered…

Development and Transition of the Radiation, Interplanetary Shocks, and Coronal Sources (RISCS) Toolset

Science.gov (United States)

Spann, James F.; Zank, G.

2014-01-01

We outline a plan to develop and transition a physics based predictive toolset called The Radiation, Interplanetary Shocks, and Coronal Sources (RISCS) to describe the interplanetary energetic particle and radiation environment throughout the inner heliosphere, including at the Earth. To forecast and "nowcast" the radiation environment requires the fusing of three components: 1) the ability to provide probabilities for incipient solar activity; 2) the use of these probabilities and daily coronal and solar wind observations to model the 3D spatial and temporal heliosphere, including magnetic field structure and transients, within 10 Astronomical Units; and 3) the ability to model the acceleration and transport of energetic particles based on current and anticipated coronal and heliospheric conditions. We describe how to address 1) - 3) based on our existing, well developed, and validated codes and models. The goal of RISCS toolset is to provide an operational forecast and "nowcast" capability that will a) predict solar energetic particle (SEP) intensities; b) spectra for protons and heavy ions; c) predict maximum energies and their duration; d) SEP composition; e) cosmic ray intensities, and f) plasma parameters, including shock arrival times, strength and obliquity at any given heliospheric location and time. The toolset would have a 72 hour predicative capability, with associated probabilistic bounds, that would be updated hourly thereafter to improve the predicted event(s) and reduce the associated probability bounds. The RISCS toolset would be highly adaptable and portable, capable of running on a variety of platforms to accommodate various operational needs and requirements. The described transition plan is based on a well established approach developed in the Earth Science discipline that ensures that the customer has a tool that meets their needs

Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling.

Science.gov (United States)

Kourtidis, Antonis; Necela, Brian; Lin, Wan-Hsin; Lu, Ruifeng; Feathers, Ryan W; Asmann, Yan W; Thompson, E Aubrey; Anastasiadis, Panos Z

2017-10-02

Cumulative evidence demonstrates that most RNAs exhibit specific subcellular distribution. However, the mechanisms regulating this phenomenon and its functional consequences are still under investigation. Here, we reveal that cadherin complexes at the apical zonula adherens (ZA) of epithelial adherens junctions recruit the core components of the RNA-induced silencing complex (RISC) Ago2, GW182, and PABPC1, as well as a set of 522 messenger RNAs (mRNAs) and 28 mature microRNAs (miRNAs or miRs), via PLEKHA7. Top canonical pathways represented by these mRNAs include Wnt/β-catenin, TGF-β, and stem cell signaling. We specifically demonstrate the presence and silencing of MYC, JUN, and SOX2 mRNAs by miR-24 and miR-200c at the ZA. PLEKHA7 knockdown dissociates RISC from the ZA, decreases loading of the ZA-associated mRNAs and miRNAs to Ago2, and results in a corresponding increase of MYC, JUN, and SOX2 protein expression. The present work reveals a mechanism that directly links junction integrity to the silencing of a set of mRNAs that critically affect epithelial homeostasis. © 2017 Kourtidis et al.

Depletion of key protein components of the RISC pathway impairs pre-ribosomal RNA processing.

Science.gov (United States)

Liang, Xue-Hai; Crooke, Stanley T

2011-06-01

Little is known about whether components of the RNA-induced silencing complex (RISC) mediate the biogenesis of RNAs other than miRNA. Here, we show that depletion of key proteins of the RISC pathway by antisense oligonucleotides significantly impairs pre-rRNA processing in human cells. In cells depleted of Drosha or Dicer, different precursors to 5.8S rRNA strongly accumulated, without affecting normal endonucleolytic cleavages. Moderate yet distinct processing defects were also observed in Ago2-depleted cells. Physical links between pre-rRNA and these proteins were identified by co-immunoprecipitation analyses. Interestingly, simultaneous depletion of Dicer and Drosha led to a different processing defect, causing slower production of 28S rRNA and its precursor. Both Dicer and Ago2 were detected in the nuclear fraction, and reduction of Dicer altered the structure of the nucleolus, where pre-rRNA processing occurs. Together, these results suggest that Drosha and Dicer are implicated in rRNA biogenesis.

IBM Brazil: and environmental modern view

Energy Technology Data Exchange (ETDEWEB)

Cremonesi, Valter [IBM Brasil, Industria, Maquinas e Servicos Ltda., Rio de Janeiro, Rj (Brazil)

1994-12-31

Information of practical experiences on Environmental Affairs at IBM Brazil plant and branch offices is presented, with a modern view of the mission, resources, support, waste management, monitoring programs, recycling, energy conservation, partners programs, nature preservation 2rograms, recognitions and image. (author). 4 figs., 2 tabs.

IBM Brazil: and environmental modern view

Energy Technology Data Exchange (ETDEWEB)

Cremonesi, Valter [IBM Brasil, Industria, Maquinas e Servicos Ltda., Rio de Janeiro, Rj (Brazil)

1993-12-31

Information of practical experiences on Environmental Affairs at IBM Brazil plant and branch offices is presented, with a modern view of the mission, resources, support, waste management, monitoring programs, recycling, energy conservation, partners programs, nature preservation 2rograms, recognitions and image. (author). 4 figs., 2 tabs.

A Real-Time Image Acquisition And Processing System For A RISC-Based Microcomputer

Science.gov (United States)

Luckman, Adrian J.; Allinson, Nigel M.

1989-03-01

A low cost image acquisition and processing system has been developed for the Acorn Archimedes microcomputer. Using a Reduced Instruction Set Computer (RISC) architecture, the ARM (Acorn Risc Machine) processor provides instruction speeds suitable for image processing applications. The associated improvement in data transfer rate has allowed real-time video image acquisition without the need for frame-store memory external to the microcomputer. The system is comprised of real-time video digitising hardware which interfaces directly to the Archimedes memory, and software to provide an integrated image acquisition and processing environment. The hardware can digitise a video signal at up to 640 samples per video line with programmable parameters such as sampling rate and gain. Software support includes a work environment for image capture and processing with pixel, neighbourhood and global operators. A friendly user interface is provided with the help of the Archimedes Operating System WIMP (Windows, Icons, Mouse and Pointer) Manager. Windows provide a convenient way of handling images on the screen and program control is directed mostly by pop-up menus.

Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification

Science.gov (United States)

Stanhope, Stephen A.; Sengupta, Srikumar; den Boon, Johan; Ahlquist, Paul; Newton, Michael A.

2009-01-01

MicroRNAs (miRNAs) posttranscriptionally regulate targeted messenger RNAs (mRNAs) by inducing cleavage or otherwise repressing their translation. We address the problem of detecting m/miRNA targeting relationships in homo sapiens from microarray data by developing statistical models that are motivated by the biological mechanisms used by miRNAs. The focus of our modeling is the construction, activity, and mediation of RNA-induced silencing complexes (RISCs) competent for targeted mRNA cleavage. We demonstrate that regression models accommodating RISC abundance and controlling for other mediating factors fit the expression profiles of known target pairs substantially better than models based on m/miRNA expressions alone, and lead to verifications of computational target pair predictions that are more sensitive than those based on marginal expression levels. Because our models are fully independent of exogenous results from sequence-based computational methods, they are appropriate for use as either a primary or secondary source of information regarding m/miRNA target pair relationships, especially in conjunction with high-throughput expression studies. PMID:19779550

IBM KELOMPOK USAHA SOUVENIR SABLON DIGITAL

Directory of Open Access Journals (Sweden)

Maria Krisnawati

2015-02-01

Full Text Available Targets to be achieved through IbM is on aspects of production and management. Aspects of the production which increased the production technology of making souvenirs, increasing capacity in the field of design through the program Corel Draw and Adobe Photoshop as well as consolidation of production procedures with due regard to health and safety work management. Management aspects namely on financial management, financial management hold good with regular bookkeeping, through marketing management produces forms of promotion through various media. Market network expansion and facilitate consumer access to order products.Through HR management can improve the training of human resources, the provision of entrepreneurial motivation and self empowerment. IbM implemented through phases 1 Preparation ; 2 Stage Assessment ; 3 The Plan or Program Activity; 4 Phase Action Plan ; 5 Implementation Phase or activity ; and 6 Evaluation Phase . It is expected to be implemented through the stages can help solve problems and realize the needs of partners.

The web server of IBM's Bioinformatics and Pattern Discovery group.

Science.gov (United States)

Huynh, Tien; Rigoutsos, Isidore; Parida, Laxmi; Platt, Daniel; Shibuya, Tetsuo

2003-07-01

We herein present and discuss the services and content which are available on the web server of IBM's Bioinformatics and Pattern Discovery group. The server is operational around the clock and provides access to a variety of methods that have been published by the group's members and collaborators. The available tools correspond to applications ranging from the discovery of patterns in streams of events and the computation of multiple sequence alignments, to the discovery of genes in nucleic acid sequences and the interactive annotation of amino acid sequences. Additionally, annotations for more than 70 archaeal, bacterial, eukaryotic and viral genomes are available on-line and can be searched interactively. The tools and code bundles can be accessed beginning at http://cbcsrv.watson.ibm.com/Tspd.html whereas the genomics annotations are available at http://cbcsrv.watson.ibm.com/Annotations/.

Dynamics of Innovation at IBM, 1945-1953

DEFF Research Database (Denmark)

Heide, Lars

The paper explores the use of sociotechnical network and sensemaking theory in early early innovation of computer technology at IBM to improve the understanding of the dynamics in innovation processes through the study of individuals’ contributions in a large company. It complements Actor Network...... Theory by Karl E. Weick’s sensemaking and studies innovation processes through narratives. This approach supplements the literature’s institutional focus and provides more focus on the technology’s use and limitations on innovations. In the mid-1940s, IBM was reluctant to engage in computer innovation......, because its sales organization and top-management saw little computer business. They subscribed to the established corporate innovation narrative of incremental improvements of the company’s many single punched-card machines, which contrasted the challenges of the revolutionary shift to computers. However...

Investigation of triaxiality in 54122-128Xe isotopes in the framework of sdg-IBM

Science.gov (United States)

Jafarizadeh, M. A.; Ranjbar, Z.; Fouladi, N.; Ghapanvari, M.

In this paper, a transitional interacting boson model (IBM) Hamiltonian in both sd-(IBM) and sdg-IBM versions based on affine SU(1, 1) Lie algebra is employed to describe deviations from the gamma-unstable nature of Hamiltonian along the chain of Xe isotopes. sdg-IBM Hamiltonian proposed a better interpretation of this deviation which cannot be explained in the sd-boson models. The nuclei studied have well-known γ bands close to the γ-unstable limit. The energy levels, B(E2) transition rates and signature splitting of the γ -vibrational band are calculated via the affine SU(1,1) Lie algebra. An acceptable degree of agreement was achieved based on this procedure. It is shown that in these isotopes the signature splitting is better reproduced by the inclusion of sdg-IBM. In none of them, any evidence for a stable, triaxial ground state shape is found.

A performance evaluation of the IBM 370/XT personal computer

Science.gov (United States)

Dominick, Wayne D. (Editor); Triantafyllopoulos, Spiros

1984-01-01

An evaluation of the IBM 370/XT personal computer is given. This evaluation focuses primarily on the use of the 370/XT for scientific and technical applications and applications development. A measurement of the capabilities of the 370/XT was performed by means of test programs which are presented. Also included is a review of facilities provided by the operating system (VM/PC), along with comments on the IBM 370/XT hardware configuration.

Latvijas sabiedrisko attiecību aģentūru prakse plānotas krīzes komunikācijas vadīšanā

OpenAIRE

Štokmane, Linda

2014-01-01

Darba nosaukums ir „Latvijas sabiedrisko attiecību aģentūru prakse plānotas krīzes komunikācijas vadīšanā”. Pētījuma problēma - vai krīzes situācijām iespējams sagatavoties un kā iepriekš plānota un sagatavota komunikācija spēj palīdzēt efektīvāk vadīt krīzes situācijas? Bakalaura darba mērķis ir izpētīt, kāda ir Latvijas sab iedrisko attiecību aģentūru prakse un pieredze krīzes komunikācijas plānošanā un vadīšanā. Darba teorētiskā bāze, galvenokārt, balstīta uz situatīvo krīzes komunikāci...

An Efficient Power Estimation Methodology for Complex RISC Processor-based Platforms

OpenAIRE

Rethinagiri , Santhosh Kumar; Ben Atitallah , Rabie; Dekeyser , Jean-Luc; Niar , Smail; Senn , Eric

2012-01-01

International audience; In this contribution, we propose an efficient power estima- tion methodology for complex RISC processor-based plat- forms. In this methodology, the Functional Level Power Analysis (FLPA) is used to set up generic power models for the different parts of the system. Then, a simulation framework based on virtual platform is developed to evalu- ate accurately the activities used in the related power mod- els. The combination of the two parts above leads to a het- erogeneou...

Users guide for the ANL IBM SPx

Energy Technology Data Exchange (ETDEWEB)

Gropp, W.; Lusk, E.

1994-12-01

This guide presents the features of the IBM SPx installed in the Mathematics and Computer Science Division at Argonne National Laboratory. The guide describes the available hardware and software, access policies, and hints for using the system productively.

IBM PC based real time photon correlator [Paper No.:D2

International Nuclear Information System (INIS)

Kumaravadivelu, C.; Nageswaran, A.; Weling, S. A.

1993-01-01

The design aspects and development of IBM PC based real time photon correlator is presented. This system computes 64 auto-correlation functions in real time. Sample data is 4-bit wide. Correlation functions are computed in hard wired logic using discrete components. A combination of parallel and pipelined architecture is adopted to compute the correlation in realtime. A high speed controller generates the required control signals for the computing hardware and also provides handshake signals to IBM PC to access the computed results. IBM PC bus is extended and interfaced to correlation computing hardware. IBM PC collects the experimental parameters through user friendly menu and initiates the correlation hardware and continues to collect the correlation build ups and displays them on the screen. Extensive test and maintenance features are incorporated into the system. This system is developed for Material Science Division in Indira Gandhi Centre for Atomic Research (IGCAR) to study static and dynamic properties of macro molecules and colloidal particles in dispersion using light scattering technique. It can also be used to study the flow characteristics of sodium in nuclear reactors. It can be used in dynamic neutron scattering experiments. (author). 3 figs., 2 tabs

A Comparison of the Apple Macintosh and IBM PC in Laboratory Applications.

Science.gov (United States)

Williams, Ron

1986-01-01

Compares Apple Macintosh and IBM PC microcomputers in terms of their usefulness in the laboratory. No attempt is made to equalize the two computer systems since they represent opposite ends of the computer spectrum. Indicates that the IBM PC is the most useful general-purpose personal computer for laboratory applications. (JN)

Design of multichannel counting system for IBM PC and compatibles

International Nuclear Information System (INIS)

Majeed, B.; Ahmad, Z.; Osman, A.; Ysain, M.M.

1995-07-01

A Multichannel Counting System (MCCS), based on IBM-PC and compatible computer systems have been designed. The MCCS consists of a Multichannel Counting System plug-in interface card (MCCS-PC) for IBM PC and compatibles and a NIM-BIN module (MCCS-NB). The MCCS-PC provides simultaneous monitoring of upto seven independent SCA type inputs. An on board programmable timer provides elapsed time measurement. A menu-driven program for data acquisition and timer control has also been developed. (author) 8 figs

IBM 3480 tape cartridge

CERN Multimedia

1984-01-01

The 3480 tape format is a magnetic tape data storage format developed by IBM. The cartridge contains a single reel. IBM’s 3480 cartridge tape system sought to replace the traditional reels of magnetic tape in the computer center. Because of their speed, reliability, durability and low media cost, these tapes and tape drives are still in high demand. A hallmark of the genre is transferability. Tapes recorded with one tape drive are generally readable on another drive, even if the tape drives were built by different manufacturers.

Sensing miRNA: Signal Amplification by Cognate RISC for Intracellular Detection of miRNA in Live Cells.

Science.gov (United States)

Kavishwar, Amol; Medarova, Zdravka

2016-01-01

The ability to detect miRNA expression in live cells would leave these cells available for further manipulation or culture. Here, we describe the design of a miRNA sensor oligonucleotide whose sequence mimics the target mRNA. The sensor has a fluorescent label on one end of the oligo and a quencher on the other. When inside the cell, the sensor is recognized by its cognate miRNA-RISC and gets cleaved, setting the fluorophore free from its quencher. This results in fluorescence "turn on." Since cleavage by the RISC complex is an enzymatic process, the described approach has a very high level of sensitivity (nM). The rate of nonspecific cleavage of the sensor is very slow permitting the collection of meaningful signal over a long period of time.

EZVIDEO, DISSPLA Graphics Software Simulation on IBM PC

International Nuclear Information System (INIS)

1991-01-01

1 - Description of program or function: EZVIDEO simulates a subset of the DISSPLA plotting package to make plots on the IBM PC screen. Screen dumps can also be made to an attached LaserJet or Epson printer to make hard copy without using terminal emulators. The forerunner of EZVIDEO was called EZPLOT. 2 - Method of solution: The subroutines in the EZVIDEO system are based on the Hewlett Packard HP 9000 simulation of DISSPLA. These routines manipulate the pen movements on the screen and are also capable of capturing these same movements so that a hardcopy can be made to dot matrix or laser printer. 3 - Restrictions on the complexity of the problem: For plotting on the IBM PC, the plotting emulator PCPLOT is needed

Determining the Velocity Fine Structure by a Laser Anemometer in VAD operation

DEFF Research Database (Denmark)

Kristensen, Leif; Kirkegaard, Peter; Mikkelsen, Torben

. Then it is necessary to “create” a mean wind by turning the laser beam. Since the instrument is not moved the beam will describe a cone which could be a VAD-scanning. In any case the measured velocity components will not be parallel and this implies that the measured structure function will contain a term which...... is proportional to the total variance. The theoretical expression for the line-filtered structure function is derived in two equivalent ways, one in physical space and one in wave-number space, of which the last can be reliably evaluated by numerical integration. Also a practical approximate equation, derived...

Introducing RISC: A New Video Inventory for Testing Social Perception.

Science.gov (United States)

Rothermich, Kathrin; Pell, Marc D

2015-01-01

Indirect forms of speech, such as sarcasm, jocularity (joking), and 'white lies' told to spare another's feelings, occur frequently in daily life and are a problem for many clinical populations. During social interactions, information about the literal or nonliteral meaning of a speaker unfolds simultaneously in several communication channels (e.g., linguistic, facial, vocal, and body cues); however, to date many studies have employed uni-modal stimuli, for example focusing only on the visual modality, limiting the generalizability of these results to everyday communication. Much of this research also neglects key factors for interpreting speaker intentions, such as verbal context and the relationship of social partners. Relational Inference in Social Communication (RISC) is a newly developed (English-language) database composed of short video vignettes depicting sincere, jocular, sarcastic, and white lie social exchanges between two people. Stimuli carefully manipulated the social relationship between communication partners (e.g., boss/employee, couple) and the availability of contextual cues (e.g. preceding conversations, physical objects) while controlling for major differences in the linguistic content of matched items. Here, we present initial perceptual validation data (N = 31) on a corpus of 920 items. Overall accuracy for identifying speaker intentions was above 80% correct and our results show that both relationship type and verbal context influence the categorization of literal and nonliteral interactions, underscoring the importance of these factors in research on speaker intentions. We believe that RISC will prove highly constructive as a tool in future research on social cognition, inter-personal communication, and the interpretation of speaker intentions in both healthy adults and clinical populations.

Development of the Respiratory Index of Severity in Children (RISC score among young children with respiratory infections in South Africa.

Directory of Open Access Journals (Sweden)

Carrie Reed

Full Text Available OBJECTIVE: Pneumonia is a leading cause of death in children worldwide. A simple clinical score predicting the probability of death in a young child with lower respiratory tract infection (LRTI could aid clinicians in case management and provide a standardized severity measure during epidemiologic studies. METHODS: We analyzed 4,148 LRTI hospitalizations in children <24 months enrolled in a pneumococcal conjugate vaccine trial in South Africa from 1998-2001, to develop the Respiratory Index of Severity in Children (RISC. Using clinical data at admission, a multivariable logistic regression model for mortality was developed and statistically evaluated using bootstrap resampling techniques. Points were assigned to risk factors based on their coefficients in the multivariable model. A child's RISC score is the sum of points for each risk factor present. Separate models were developed for HIV-infected and non-infected children. RESULTS: Significant risk factors for HIV-infected and non-infected children included low oxygen saturation, chest indrawing, wheezing, and refusal to feed. The models also included age and HIV clinical classification (for HIV-infected children or weight-for-age (for non-infected children. RISC scores ranged up to 7 points for HIV-infected or 6 points for non-infected children and correlated with probability of death (0-47%, HIV-infected; 0-14%, non-infected. Final models showed good discrimination (area under the ROC curve and calibration (goodness-of-fit. CONCLUSION: The RISC score incorporates a simple set of risk factors that accurately discriminate between young children based on their risk of death from LRTI, and may provide an objective means to quantify severity based on the risk of mortality.

76 FR 174 - International Business Machines (IBM), Global Sales Operations Organization, Sales and...

Science.gov (United States)

2011-01-03

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,575; TA-W-74,575D] International Business Machines (IBM), Global Sales Operations Organization, Sales and Distribution Business Manager Roles; One Teleworker Located in Charleston, WV; International Business Machines (IBM), Global Sales Operations Organization, Sales and...

Microscopic IBM-1 description of collective states in 128Ce

Directory of Open Access Journals (Sweden)

Mikhajlov V. M.

2012-12-01

Full Text Available Microscopical quasiparticle theory is developed to calculate the IBM-1 parameters entering the Hamiltonian and E2–operator. The theory takes into account the impact of noncollective phonons and predicts alterations of the superconducting properties along the excitation spectrum, whereas the most collective phonon (the image of the IBM d-boson is practically invariable. Calculations of the energy spectrum and probabilities of E2–transitions (without effective nucleon charges were performed for 128Ce. The results obtained are in satisfactory agreement with experimental data.

The ALICE Magnetic System Computation.

CERN Document Server

Klempt, W; CERN. Geneva; Swoboda, Detlef

1995-01-01

In this note we present the first results from the ALICE magnetic system computation performed in the 3-dimensional way with the Vector Fields TOSCA code (version 6.5) [1]. To make the calculations we have used the IBM RISC System 6000-370 and 6000-550 machines combined in the CERN PaRC UNIX cluster.

RISC-type microprocessors may revolutionize aerospace simulation

Science.gov (United States)

Jackson, Albert S.

The author explores the application of RISC (reduced instruction set computer) processors in massively parallel computer (MPC) designs for aerospace simulation. The MPC approach is shown to be well adapted to the needs of aerospace simulation. It is shown that any of the three common types of interconnection schemes used with MPCs are effective for general-purpose simulation, although the bus-or switch-oriented machines are somewhat easier to use. For partial differential equation models, the hypercube approach at first glance appears more efficient because the nearest-neighbor connections required for three-dimensional models are hardwired in a hypercube machine. However, the data broadcast ability of a bus system, combined with the fact that data can be transmitted over a bus as soon as it has been updated, makes the bus approach very competitive with the hypercube approach even for these types of models.

RISC-RAD. A European integrated approach to the problem of low doses

International Nuclear Information System (INIS)

Meunier, A.; Sabatier, L.; Atkinson, M.; Paretzke, H.; Bouffler, S.; Mullenders, L.

2007-01-01

Complete text of publication follows. Funded by the European Commission in the framework of a dedicated programme supporting research in the Nuclear sector (FP6 Euratom), the project RISC-RAD undertakes experimental and modelling studies ultimately to improve low dose radiation cancer risk assessment by exploring and providing evidence for the most appropriate radiation cancer risk projection and interpolation models. It started on 1st January 2004 and is running until 31 st October 2008. It mobilizes a consortium of 31 partners and is coordinated by Dr. Laure Sabatier from the French atomic energy commission. Indeed the project represents an unprecedented attempt to integrate horizontally the research on the effects of low doses of IR at the European level. A multipartner project supporting objective-driven research, RISC-RAD aims at contributing to bridge the remaining gap of scientific knowledge about effects of lows doses of ionizing radiation. It spans a large part of the research spectrum, including many topics addressed during the LOWRAD2007 conference. This presentation intends to give an account of the integrative aspects of the project, insights on the innovative solutions found to approach a complex and controversial scientific topic like the biological effects of low doses of ionizing radiation, and links with some areas of social studies on science.The concept of 'integration' implies the development of a new kind of activity in the research field, which crosses its traditional boundaries : controversies of several kinds must temporarily be overcome within the project management board in order to define and follow a common strategy. Among them, how to reconcile the creative part of fundamental research with the compliance to strict project planning rules has come up as a debate which questions the best way a significant collective and coordinated action can address the issue of the low dose cancer risk assessment on the long term. The knowledge and

IBM-PC-based reactor neutronics analysis package

International Nuclear Information System (INIS)

Nigg, D.W.; Wessol, D.E.; Grimesey, R.A.; Parsons, D.K.; Wheeler, F.J.; Yoon, W.Y.; Lake, J.A.

1985-01-01

Technical advances over the past few years have led to a situation where a wide range of complex scientific computations can now be done on properly configured microcomputers such as the IBM-PC (personal computer). For a number of reasons, including security, economy, and user convenience, the development of a comprehensive system of reactor neutronics codes suitable for operation on the IBM-PC has been undertaken at the Idaho National Engineering Laboratory (INEL). It is anticipated that a PC-based code system could also have wide applicability in the nuclear engineering education community since conversion of software generated by national laboratories and others to college and university mainframe hardware has historically been a time-consuming process that has sometimes met with only limited success. This paper discusses the philosophy behind the INEL reactor neutronics PC code system and describes those parts of the system that are currently complete, those that are now under development, and those that are still in the planning stage

Data Mining and Knowledge Discover - IBM Cognitive Alternatives for NASA KSC

Science.gov (United States)

Velez, Victor Hugo

2016-01-01

Skillful tools in cognitive computing to transform industries have been found favorable and profitable for different Directorates at NASA KSC. In this study is shown how cognitive computing systems can be useful for NASA when computers are trained in the same way as humans are to gain knowledge over time. Increasing knowledge through senses, learning and a summation of events is how the applications created by the firm IBM empower the artificial intelligence in a cognitive computing system. NASA has explored and applied for the last decades the artificial intelligence approach specifically with cognitive computing in few projects adopting similar models proposed by IBM Watson. However, the usage of semantic technologies by the dedicated business unit developed by IBM leads these cognitive computing applications to outperform the functionality of the inner tools and present outstanding analysis to facilitate the decision making for managers and leads in a management information system.

Correspondence between phenomenological and IBM-1 models of even isotopes of Yb

Science.gov (United States)

A. Okhunov, A.; I. Sharrad, F.; Anwer, A. Al-Sammarraie; U. Khandaker, M.

2015-08-01

Energy levels and the reduced probability of E2- transitions for ytterbium isotopes with proton number Z = 70 and neutron numbers between 100 and 106 have been calculated through phenomenological (PhM) and interacting boson (IBM-1) models. The predicted low-lying levels (energies, spins and parities) and the reduced probability for E2- transitions results are reasonably consistent with the available experimental data. The predicted low-lying levels (gr-, β1- and γ1- band) produced in the PhM are in good agreement with the experimental data compared with those by IBM-1 for all nuclei of interest. In addition, the phenomenological model was successful in predicting the β2-, β3-, β4-, γ2- and 1+ - band while it was a failure with IBM-1. Also, the 3+- band is predicted by the IBM-1 model for 172Yb and 174Yb nuclei. All calculations are compared with the available experimental data. Supported by Fundamental Research Grant Scheme (FRGS) of Ministry of Higher Education of Malaysia (FRGS13-074-0315), Islamic Development Bank (IDB) (36/11201905/35/IRQ/D31, 37/IRQ/P30)

75 FR 60141 - International Business Machines (IBM), Global Technology Services Delivery Division, Including On...

Science.gov (United States)

2010-09-29

... 25, 2010, applicable to workers of International Business Machines (IBM), Global Technology Services... hereby issued as follows: All workers of International Business Machines (IBM), Global Technology... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,164] International Business...

Desk-top publishing using IBM-compatible computers.

Science.gov (United States)

Grencis, P W

1991-01-01

This paper sets out to describe one Medical Illustration Departments' experience of the introduction of computers for desk-top publishing. In this particular case, after careful consideration of all the options open, an IBM-compatible system was installed rather than the often popular choice of an Apple Macintosh.

Networking DEC and IBM computers

Science.gov (United States)

Mish, W. H.

1983-01-01

Local Area Networking of DEC and IBM computers within the structure of the ISO-OSI Seven Layer Reference Model at a raw signaling speed of 1 Mops or greater are discussed. After an introduction to the ISO-OSI Reference Model nd the IEEE-802 Draft Standard for Local Area Networks (LANs), there follows a detailed discussion and comparison of the products available from a variety of manufactures to perform this networking task. A summary of these products is presented in a table.

Viral RNAi suppressor reversibly binds siRNA to outcompete Dicer and RISC via multiple turnover.

Science.gov (United States)

Rawlings, Renata A; Krishnan, Vishalakshi; Walter, Nils G

2011-04-29

RNA interference is a conserved gene regulatory mechanism employed by most eukaryotes as a key component of their innate immune response to viruses and retrotransposons. During viral infection, the RNase-III-type endonuclease Dicer cleaves viral double-stranded RNA into small interfering RNAs (siRNAs) 21-24 nucleotides in length and helps load them into the RNA-induced silencing complex (RISC) to guide the cleavage of complementary viral RNA. As a countermeasure, many viruses have evolved viral RNA silencing suppressors (RSS) that tightly, and presumably quantitatively, bind siRNAs to thwart RNA-interference-mediated degradation. Viral RSS proteins also act across kingdoms as potential immunosuppressors in gene therapeutic applications. Here we report fluorescence quenching and electrophoretic mobility shift assays that probe siRNA binding by the dimeric RSS p19 from Carnation Italian Ringspot Virus, as well as by human Dicer and RISC assembly complexes. We find that the siRNA:p19 interaction is readily reversible, characterized by rapid binding [(1.69 ± 0.07) × 10(8) M(-)(1) s(-1)] and marked dissociation (k(off)=0.062 ± 0.002 s(-1)). We also observe that p19 efficiently competes with recombinant Dicer and inhibits the formation of RISC-related assembly complexes found in human cell extract. Computational modeling based on these results provides evidence for the transient formation of a ternary complex between siRNA, human Dicer, and p19. An expanded model of RNA silencing indicates that multiple turnover by reversible binding of siRNAs potentiates the efficiency of the suppressor protein. Our predictive model is expected to be applicable to the dosing of p19 as a silencing suppressor in viral gene therapy. Copyright © 2011 Elsevier Ltd. All rights reserved.

Viral RNAi suppressor reversibly binds siRNA to outcompete Dicer and RISC via multiple-turnover

Science.gov (United States)

Rawlings, Renata A.; Krishnan, Vishalakshi; Walter, Nils G.

2011-01-01

RNA interference (RNAi) is a conserved gene regulatory mechanism employed by most eukaryotes as a key component of their innate immune response against viruses and retrotransposons. During viral infection, the RNase III-type endonuclease Dicer cleaves viral double-stranded RNA into small interfering RNAs (siRNAs), 21–24 nucleotides in length, and helps load them into the RNA-induced silencing complex (RISC) to guide cleavage of complementary viral RNA. As a countermeasure, many viruses have evolved viral RNA silencing suppressor (RSS) proteins that tightly, and presumably quantitatively, bind siRNAs to thwart RNAi-mediated degradation. Viral RSS proteins also act across kingdoms as potential immunosuppressors in gene therapeutic applications. Here we report fluorescence quenching and electrophoretic mobility shift assays that probe siRNA binding by the dimeric RSS p19 from Carnation Italian Ringspot Virus (CIRV), as well as by human Dicer and RISC assembly complexes. We find that the siRNA:p19 interaction is readily reversible, characterized by rapid binding ((1.69 ± 0.07)×108 M−1s−1) and marked dissociation (koff = 0.062 ± 0.002 s−1). We also observe that p19 efficiently competes with recombinant Dicer and inhibits formation of RISC-related assembly complexes found in human cell extract. Computational modeling based on these results provides evidence for the transient formation of a ternary complex between siRNA, human Dicer, and p19. An expanded model of RNA silencing indicates that multiple-turnover by reversible binding of siRNAs potentiates the efficiency of the suppressor protein. Our predictive model is expected to be applicable to the dosing of p19 as a silencing suppressor in viral gene therapy. PMID:21354178

76 FR 32231 - International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales...

Science.gov (United States)

2011-06-03

... for the workers and former workers of International Business Machines (IBM), Sales and Distribution... reconsideration alleges that IBM outsourced to India and China. During the reconsideration investigation, it was..., Armonk, New York. The subject worker group supply computer software development and maintenance services...

Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway.

Science.gov (United States)

Sibony, Michal; Abdullah, Majd; Greenfield, Laura; Raju, Deepa; Wu, Ted; Rodrigues, David M; Galindo-Mata, Esther; Mascarenhas, Heidi; Philpott, Dana J; Silverberg, Mark S; Jones, Nicola L

2015-12-01

Autophagy is implicated in Crohn's disease (CD) pathogenesis. Recent evidence suggests autophagy regulates the microRNA (miRNA)-induced silencing complex (miRISC). Therefore, autophagy may play a novel role in CD by regulating expression of miRISC, thereby altering miRNA silencing. As microbes associated with CD can alter autophagy, we hypothesized that microbial disruption of autophagy affects the critical miRISC component AGO2. AGO2 expression was assessed in epithelial and immune cells, and intestinal organoids with disrupted autophagy. Microarray technology was used to determine the expression of downstream miRNAs in cells with defective autophagy. Increased AGO2 was detected in autophagy-deficient ATG5-/- and ATG16-/- mouse embryonic fibroblast cells (MEFs) in comparison with wild-type MEFs. Chemical agents and VacA toxin, which disrupt autophagy, increased AGO2 expression in MEFs, epithelial cells lines, and human monocytes, respectively. Increased AGO2 was also detected in ATG7-/- intestinal organoids, in comparison with wild-type organoids. Five miRNAs were differentially expressed in autophagy-deficient MEFs. Pathway enrichment analysis of the differentially expressed miRNAs implicated signaling pathways previously associated with CD. Taken together, our results suggest that autophagy is involved in the regulation of the critical miRISC component AGO2 in epithelial and immune cells and primary intestinal epithelial cells. We propose a mechanism by which autophagy alters miRNA expression, which likely impacts the regulation of CD-associated pathways. Furthermore, as enteric microbial products can manipulate autophagy and AGO2, our findings suggest a novel mechanism by which enteric microbes could influence miRNA to promote disease.

Radioimmunoassay data processing program for IBM PC computers

International Nuclear Information System (INIS)

1989-06-01

The Medical Applications Section of the International Atomic Energy Agency (IAEA) has previously developed several programs for use on the Hewlett-Packard HP-41C programmable calculator to facilitate better quality control in radioimmunoassay through improved data processing. The program described in this document is designed for off-line analysis using an IBM PC (or compatible) for counting data from standards and unknown specimens (i.e. for analysis of counting data previously recorded by a counter), together with internal quality control (IQC) data both within and between batch. The greater computing power of the IBM PC has enabled the imprecision profile and IQC control curves which were unavailable on the HP-41C version. It is intended that the program would make available good data processing capability to laboratories having limited financial resources and serious problems of quality control. 3 refs

Introducing RISC: A New Video Inventory for Testing Social Perception.

Directory of Open Access Journals (Sweden)

Kathrin Rothermich

Full Text Available Indirect forms of speech, such as sarcasm, jocularity (joking, and 'white lies' told to spare another's feelings, occur frequently in daily life and are a problem for many clinical populations. During social interactions, information about the literal or nonliteral meaning of a speaker unfolds simultaneously in several communication channels (e.g., linguistic, facial, vocal, and body cues; however, to date many studies have employed uni-modal stimuli, for example focusing only on the visual modality, limiting the generalizability of these results to everyday communication. Much of this research also neglects key factors for interpreting speaker intentions, such as verbal context and the relationship of social partners. Relational Inference in Social Communication (RISC is a newly developed (English-language database composed of short video vignettes depicting sincere, jocular, sarcastic, and white lie social exchanges between two people. Stimuli carefully manipulated the social relationship between communication partners (e.g., boss/employee, couple and the availability of contextual cues (e.g. preceding conversations, physical objects while controlling for major differences in the linguistic content of matched items. Here, we present initial perceptual validation data (N = 31 on a corpus of 920 items. Overall accuracy for identifying speaker intentions was above 80% correct and our results show that both relationship type and verbal context influence the categorization of literal and nonliteral interactions, underscoring the importance of these factors in research on speaker intentions. We believe that RISC will prove highly constructive as a tool in future research on social cognition, inter-personal communication, and the interpretation of speaker intentions in both healthy adults and clinical populations.

A novel rotometer based on a RISC microcontroller.

Science.gov (United States)

Heredia-López, F J; Bata-García, J L; Alvarez-Cervera, F J; Góngora-Alfaro, J L

2002-08-01

A new, low-cost rotometer, based on a reduced instruction set computer (RISC) microcontroller, is presented. Like earlier devices, it counts the number and direction of full turns for predetermined time periods during the evaluation of turning behavior induced by drug administration in rats. The present stand-alone system includes a nonvolatile memory for long-term data storage and a serial port for data transmission. It also contains a display for monitoring the experiments and has battery backup to avoid interruptions owing to power failures. A high correlation was found (r > .988, p < 2 x 10(-14)) between the counts of the rotometer and those of two trained observers. The system reflects quantitative differences in turning behavior owing to pharmacological manipulations. It provides the most common counting parameters and is inexpensive, flexible, highly reliable, and completely portable (weight including batteries, 159 g).

Functional analysis of neuronal microRNAs in Caenorhabditis elegans dauer formation by combinational genetics and Neuronal miRISC immunoprecipitation.

Directory of Open Access Journals (Sweden)

Minh T Than

2013-06-01

Full Text Available Identifying the physiological functions of microRNAs (miRNAs is often challenging because miRNAs commonly impact gene expression under specific physiological conditions through complex miRNA::mRNA interaction networks and in coordination with other means of gene regulation, such as transcriptional regulation and protein degradation. Such complexity creates difficulties in dissecting miRNA functions through traditional genetic methods using individual miRNA mutations. To investigate the physiological functions of miRNAs in neurons, we combined a genetic "enhancer" approach complemented by biochemical analysis of neuronal miRNA-induced silencing complexes (miRISCs in C. elegans. Total miRNA function can be compromised by mutating one of the two GW182 proteins (AIN-1, an important component of miRISC. We found that combining an ain-1 mutation with a mutation in unc-3, a neuronal transcription factor, resulted in an inappropriate entrance into the stress-induced, alternative larval stage known as dauer, indicating a role of miRNAs in preventing aberrant dauer formation. Analysis of this genetic interaction suggests that neuronal miRNAs perform such a role partly by regulating endogenous cyclic guanosine monophosphate (cGMP signaling, potentially influencing two other dauer-regulating pathways. Through tissue-specific immunoprecipitations of miRISC, we identified miRNAs and their likely target mRNAs within neuronal tissue. We verified the biological relevance of several of these miRNAs and found that many miRNAs likely regulate dauer formation through multiple dauer-related targets. Further analysis of target mRNAs suggests potential miRNA involvement in various neuronal processes, but the importance of these miRNA::mRNA interactions remains unclear. Finally, we found that neuronal genes may be more highly regulated by miRNAs than intestinal genes. Overall, our study identifies miRNAs and their targets, and a physiological function of these miRNAs in

Caso de estudio. IBM: ¿Más allá del conocimiento...?

OpenAIRE

Vernaza Pacheco, Pablo José; Velásquez Vásquez, Francisco Orlando

2006-01-01

El caso muestra cómo los presidentes Louis Gerstner y Samuel Palmesano lograron influir en un cambio positivo de las personas, sus valores y conocimientos, para que IBM recuperara el liderazgo en el mercado. IBM empieza a generar conocimiento y logra ser una de las empresas que más patentes ha registrado en los Estados Unidos durante la última década. El caso también plantea dilemas donde se cuestiona si la investigación y el conocimiento adquirido por las empresas ha servido o no para ...

BRT-1 code for IBM 370/135

International Nuclear Information System (INIS)

Preda, I.

1976-01-01

BRT-1 is a transport code to obtain the thermal neutrons spectrum, point dependent, in one reactor cell. The code BRT-1 described in this paper, is the code BRT-1, written in FORTRAN IV language for the computer UNIVAC 1108 with CSCX operating system, converted for the computer IBM 370/135 disk operating system. (author)

Pretreatment with Pancaspase Inhibitor (Z-VAD-FMK Delays but Does Not Prevent Intraperitoneal Heat-Killed Group B Streptococcus-Induced Preterm Delivery in a Pregnant Mouse Model

Directory of Open Access Journals (Sweden)

Ozlem Equils

2009-01-01

Full Text Available Caspases and apoptosis are thought to play a role in infection-associated preterm-delivery. We have shown that in vitro treatment with pancaspase inhibitor Z-VAD-FMK protects trophoblasts from microbial antigen-induced apoptosis. Objective. To examine whether in vivo administration of Z-VAD-FMK would prevent infection-induced preterm-delivery. Methods. We injected 14.5 day-pregnant-mice with heat-killed group B streptococcus (HK-GBS. Apoptosis within placentas and membranes was assessed by TUNEL staining. Calpain expression and caspase-3 activation were assessed by immunohistochemistry. Preterm-delivery was defined as expulsion of a fetus within 48 hours after injection. Results. Intrauterine (i.u. or intraperitoneal (i.p. HK-GBS injection led to preterm-delivery and induced apoptosis in placentas and membranes at 14 hours. The expression of calpain, a caspase-independent inducer of apoptosis, was increased in placenta. Treatment with the specific caspase inhibitor Z-VAD-FMK (i.p. prior to HK-GBS (i.p. delayed but did not prevent preterm-delivery. Conclusion. Caspase-dependent apoptosis appears to play a role in the timing but not the occurrence of GBS-induced preterm delivery in the mouse.

CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (IBM PC VERSION)

Science.gov (United States)

Donnell, B.

1994-01-01

command line version. For the UNIX version of CLIPS 6.0, the command line interface has been successfully implemented on a Sun4 running SunOS, a DECstation running DEC RISC ULTRIX, an SGI Indigo Elan running IRIX, a DEC Alpha AXP running OSF/1, and an IBM RS/6000 running AIX. Command line interface executables are included for Sun4 computers running SunOS 4.1.1 or later and for the DEC RISC ULTRIX platform. The makefiles may have to be modified slightly to be used on other UNIX platforms. The UNIX, Macintosh, and IBM PC versions of CLIPS 6.0 each have a platform specific interface. Source code, a makefile, and an executable for the Windows 3.1 interface version of CLIPS 6.0 are provided only on the IBM PC distribution diskettes. Source code, a makefile, and an executable for the Macintosh interface version of CLIPS 6.0 are provided only on the Macintosh distribution diskettes. Likewise, for the UNIX version of CLIPS 6.0, only source code and a makefile for an X-Windows interface are provided. The X-Windows interface requires MIT's X Window System, Version 11, Release 4 (X11R4), the Athena Widget Set, and the Xmu library. The source code for the Athena Widget Set is provided on the distribution medium. The X-Windows interface has been successfully implemented on a Sun4 running SunOS 4.1.2 with the MIT distribution of X11R4 (not OpenWindows), an SGI Indigo Elan running IRIX 4.0.5, and a DEC Alpha AXP running OSF/1 1.2. The VAX version of CLIPS 6.0 comes only with the generic command line interface. ASCII makefiles for the command line version of CLIPS are provided on all the distribution media for UNIX, VMS, and DOS. Four executables are provided with the IBM PC version: a windowed interface executable for Windows 3.1 built using Borland C++ v3.1, an editor for use with the windowed interface, a command line version of CLIPS for Windows 3.1, and a 386 command line executable for DOS built using Zortech C++ v3.1. All four executables are capable of utilizing extended memory

The GF11 project at IBM

International Nuclear Information System (INIS)

Sexton, J.C.

1990-01-01

The GF11 project at IBM's T. J. Watson Research Center is entering full production for QCD numerical calculations. This paper describes the GF11 hardware and system software, and discusses the first production program which has been developed to run on GF11. This program is a variation of the Cabbibo Marinari pure gauge Monte Carlo program for SU(3) and is currently sustaining almost 6 gigaflops on 360 processors in GF11

The GF11 project at IBM

Science.gov (United States)

Sexton, James C.

1990-08-01

The GF11 project at IBM's T. J. Watson Research Center is entering full production for QCD numerical calculations. This paper describes the GF11 hardware and system software, and discusses the first production program which has been developed to run on GF11. This program is a variation of the Cabbibo Marinari pure gauge Monte Carlo program for SU(3) and is currently sustaining almost 6 gigaflops on 360 processors in GF11.

Jazz亮相IBM RSDC

Institute of Scientific and Technical Information of China (English)

无

2008-01-01

6月2号,IBM在IBM Rational Software开发会议上宣布,今年年底前将有20款采用Jazz技术的产品出炉,而且最终是开放源代码的。Jazz并不是一个产品而是一项技术,这项技术主要能够加强企业在协同作业上的能力。Jazz的原意是爵士音乐,最早的爵士音乐融合了欧洲的古典音乐、军乐、流行音乐和舞曲。

Fabled IBM Tank nears launch without key features

CERN Multimedia

2003-01-01

"IBM is preparing to roll out the TotalStorage SAN File System, the ballyhooed, renamed, much delayed Storage Tank the company's been working on for ages, although it now appears some of its key capabilities won't appear until next year in a later version" (1 page).

Bus and Tag Terminators for IBM system/360

CERN Multimedia

Control units were connected to the channels with "Bus and Tag" cable pairs. The bus cables carried the address and data information and the tag cables identified what data was on the bus. There were three general types of bus-and-tag cables produced by IBM.

Context Switching with Multiple Register Windows: A RISC Performance Study

Science.gov (United States)

Konsek, Marion B.; Reed, Daniel A.; Watcharawittayakul, Wittaya

1987-01-01

Although previous studies have shown that a large file of overlapping register windows can greatly reduce procedure call/return overhead, the effects of register windows in a multiprogramming environment are poorly understood. This paper investigates the performance of multiprogrammed, reduced instruction set computers (RISCs) as a function of window management strategy. Using an analytic model that reflects context switch and procedure call overheads, we analyze the performance of simple, linearly self-recursive programs. For more complex programs, we present the results of a simulation study. These studies show that a simple strategy that saves all windows prior to a context switch, but restores only a single window following a context switch, performs near optimally.

Performance of large-scale scientific applications on the IBM ASCI Blue-Pacific system

International Nuclear Information System (INIS)

Mirin, A.

1998-01-01

The IBM ASCI Blue-Pacific System is a scalable, distributed/shared memory architecture designed to reach multi-teraflop performance. The IBM SP pieces together a large number of nodes, each having a modest number of processors. The system is designed to accommodate a mixed programming model as well as a pure message-passing paradigm. We examine a number of applications on this architecture and evaluate their performance and scalability

The web server of IBM's Bioinformatics and Pattern Discovery group: 2004 update.

Science.gov (United States)

Huynh, Tien; Rigoutsos, Isidore

2004-07-01

In this report, we provide an update on the services and content which are available on the web server of IBM's Bioinformatics and Pattern Discovery group. The server, which is operational around the clock, provides access to a large number of methods that have been developed and published by the group's members. There is an increasing number of problems that these tools can help tackle; these problems range from the discovery of patterns in streams of events and the computation of multiple sequence alignments, to the discovery of genes in nucleic acid sequences, the identification--directly from sequence--of structural deviations from alpha-helicity and the annotation of amino acid sequences for antimicrobial activity. Additionally, annotations for more than 130 archaeal, bacterial, eukaryotic and viral genomes are now available on-line and can be searched interactively. The tools and code bundles continue to be accessible from http://cbcsrv.watson.ibm.com/Tspd.html whereas the genomics annotations are available at http://cbcsrv.watson.ibm.com/Annotations/.

Quantitative analysis and IBM SPSS statistics a guide for business and finance

CERN Document Server

Aljandali, Abdulkader

2016-01-01

This guide is for practicing statisticians and data scientists who use IBM SPSS for statistical analysis of big data in business and finance. This is the first of a two-part guide to SPSS for Windows, introducing data entry into SPSS, along with elementary statistical and graphical methods for summarizing and presenting data. Part I also covers the rudiments of hypothesis testing and business forecasting while Part II will present multivariate statistical methods, more advanced forecasting methods, and multivariate methods. IBM SPSS Statistics offers a powerful set of statistical and information analysis systems that run on a wide variety of personal computers. The software is built around routines that have been developed, tested, and widely used for more than 20 years. As such, IBM SPSS Statistics is extensively used in industry, commerce, banking, local and national governments, and education. Just a small subset of users of the package include the major clearing banks, the BBC, British Gas, British Airway...

RNAi and retroviruses: are they in RISC?

Science.gov (United States)

Vasselon, Thierry; Bouttier, Manuella; Saumet, Anne; Lecellier, Charles-Henri

2013-02-01

RNA interference (RNAi) is a potent cellular system against viruses in various organisms. Although common traits are observed in plants, insects, and nematodes, the situation observed in mammals appears more complex. In mammalian somatic cells, RNAi is implicated in endonucleolytic cleavage mediated by artificially delivered small interfering RNAs (siRNAs) as well as in translation repression mediated by microRNAs (miRNAs). Because siRNAs and miRNAs recognize viral mRNAs, RNAi inherently limits virus production and participates in antiviral defense. However, several observations made in the cases of hepatitis C virus and retroviruses (including the human immunodeficiency virus and the primate foamy virus) bring evidence that this relationship is much more complex and that certain components of the RNAi effector complex [called the RNA-induced silencing complex (RISC)], such as AGO2, are also required for viral replication. Here, we summarize recent discoveries that have revealed this dual implication in virus biology. We further discuss their potential implications for the functions of RNAi-related proteins, with special emphasis on retrotransposition and genome stability.

A framework for WRF to WRF-IBM grid nesting to enable multiscale simulations

Energy Technology Data Exchange (ETDEWEB)

Wiersema, David John [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California, Berkeley, CA (United States); Lundquist, Katherine A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Chow, Fotini Katapodes [Univ. of California, Berkeley, CA (United States)

2016-09-29

With advances in computational power, mesoscale models, such as the Weather Research and Forecasting (WRF) model, are often pushed to higher resolutions. As the model’s horizontal resolution is refined, the maximum resolved terrain slope will increase. Because WRF uses a terrain-following coordinate, this increase in resolved terrain slopes introduces additional grid skewness. At high resolutions and over complex terrain, this grid skewness can introduce large numerical errors that require methods, such as the immersed boundary method, to keep the model accurate and stable. Our implementation of the immersed boundary method in the WRF model, WRF-IBM, has proven effective at microscale simulations over complex terrain. WRF-IBM uses a non-conforming grid that extends beneath the model’s terrain. Boundary conditions at the immersed boundary, the terrain, are enforced by introducing a body force term to the governing equations at points directly beneath the immersed boundary. Nesting between a WRF parent grid and a WRF-IBM child grid requires a new framework for initialization and forcing of the child WRF-IBM grid. This framework will enable concurrent multi-scale simulations within the WRF model, improving the accuracy of high-resolution simulations and enabling simulations across a wide range of scales.

Reliability and validity of the Spanish version of the 10-item Connor-Davidson Resilience Scale (10-item CD-RISC in young adults

Directory of Open Access Journals (Sweden)

García-Campayo Javier

2011-08-01

Full Text Available Abstract Background The 10-item Connor-Davidson Resilience Scale (10-item CD-RISC is an instrument for measuring resilience that has shown good psychometric properties in its original version in English. The aim of this study was to evaluate the validity and reliability of the Spanish version of the 10-item CD-RISC in young adults and to verify whether it is structured in a single dimension as in the original English version. Findings Cross-sectional observational study including 681 university students ranging in age from 18 to 30 years. The number of latent factors in the 10 items of the scale was analyzed by exploratory factor analysis. Confirmatory factor analysis was used to verify whether a single factor underlies the 10 items of the scale as in the original version in English. The convergent validity was analyzed by testing whether the mean of the scores of the mental component of SF-12 (MCS and the quality of sleep as measured with the Pittsburgh Sleep Index (PSQI were higher in subjects with better levels of resilience. The internal consistency of the 10-item CD-RISC was estimated using the Cronbach α test and test-retest reliability was estimated with the intraclass correlation coefficient. The Cronbach α coefficient was 0.85 and the test-retest intraclass correlation coefficient was 0.71. The mean MCS score and the level of quality of sleep in both men and women were significantly worse in subjects with lower resilience scores. Conclusions The Spanish version of the 10-item CD-RISC showed good psychometric properties in young adults and thus can be used as a reliable and valid instrument for measuring resilience. Our study confirmed that a single factor underlies the resilience construct, as was the case of the original scale in English.

IBM-i ja Lenovo juhid külastasid Eestit

Index Scriptorium Estoniae

2006-01-01

8.-9. maini 2006. a. viibisid Tallinnas IBM-Lenovo Alliance'i viitsepresident Simon L. Porter ja Lenovo Soome regiooni juhataja Jukka Mäntylä, kes kohtusid kohaliku IT-pressiga ning esitlesid Tallinna Botaanikaaia Palmimaja seminarikeskuses mõlema firma uudiseid

IBM Eesti loodab ELiga liitumisest tulu lõigata / Annika Matson

Index Scriptorium Estoniae

Matson, Annika, 1976-

2003-01-01

Maailma juhtiva infotehnoloogiafirma IBM Eesti tütarettevõte näeb Eesti liitumises Euroopa Liiduga endale uusi võimalusi Euroopa turul, eriti dokumendihalduse valdkonnas. Diagramm: IBMi aktsia viimased kolm aastat

Comparison of the AMDAHL 470V/6 and the IBM 370/195 using benchmarks

Energy Technology Data Exchange (ETDEWEB)

Snider, D.R.; Midlock, J.L.; Hinds, A.R.; Engert, D.E.

1976-03-01

Six groups of jobs were run on the IBM 370/195 at the Applied Mathematics Division (AMD) of Argonne National Laboratory using the current production versions of OS/MVT 21.7 and ASP 3.1. The same jobs were then run on an AMDAHL 470V/6 at the AMDAHL manufacturing facilities in Sunnyvale, California, using the identical operating systems. Performances of the two machines are compared. Differences in the configurations were minimized. The memory size on each machine was the same, all software which had an impact on run times was the same, and the I/O configurations were as similar as possible. This allowed the comparison to be based on the relative performance of the two CPU's. As part of the studies preliminary to the acquisition of the IBM 195 in 1972, two of the groups of jobs had been run on a CDC 7600 by CDC personnel in Arden Hills, Minnesota, on an IBM 360/195 by IBM personnel in Poughkeepsie, New York, and on the AMD 360/50/75 production system in June, 1971. 6 figures, 9 tables.

BOAST II for the IBM 3090 and RISC 6000. Final report

Energy Technology Data Exchange (ETDEWEB)

Hebert, P.; Bourgoyne, A.T. Jr.; Tyler, J.

1993-05-01

BOAST II simulates isothermal, darcy flow in three dimensions. It assumes that reservoir liquids can be described in three fluid phases (oil, gas, and water) of constant composition, with physical properties that depend on pressure, only. These reservoir fluid approximations are acceptable for a large percentage of the world`s oil and gas reservoirs. Consequently, BOAST II has a wide range of applicability. BOAST II can simulate oil and/or gas recovery by fluid expansion, displacement, gravity drainage, and capillary imbibition mechanisms. Typical field production problems that BOAST II can handle include primary depletion studies, pressure maintenance by water and/or gas injection, and evaluation of secondary recovery waterflooding and displacement operations. Technically, BOAST II is a finite, implicit pressure, explicit saturation (IMPES) numerical simulator. It applies both direct and iterative solution techniques for solving systems of algebraic equations. The well model allows specification of rate or pressure constraints on well performance, and the user is free to add or to recomplete wells during the simulation. In addition, the user can define multiple rock and PVT regions and can choose from three aquifer models. BOAST II also provides flexible initialization, a bubble-point tracking scheme, automatic time-step control, and a material balance check on solution stability. The user controls output, which includes a run summary and line-printer plots of fieldwide performance.

AGRIS: Categorization and information retrieval based on IBM's IRMS

International Nuclear Information System (INIS)

Schmid, H.; Leatherdale, D.

1976-01-01

The subject breakdown of the AGRIS data base by categories interlinked with object and geographical codes is described. The use of these categories and codes in a mechanized information retrieval system is then considered. The system is a modification of IBM's Information Retrieval and Management System (IRMS); it allows for batch processing on an IBM/360 or /370 computer operated under OS or VS. As IRMS was developed for use with a controlled vocabulary, the search possibilities on the AGRIS files are necessarily limited. An artificial vocabulary is presented, derived from the AGRIS subject categories, object codes, geographic codes, language codes, and bibliographic data: type of record, literary indicator, volume/issue number, and the country code of the submitting centre. The use of the IRMS system for AGRIS is described, with details of programming deliberately omitted. Program descriptions with data set definitions and file formats are presented separately

Validity and reliability of the Spanish version of the 10-item CD-RISC in patients with fibromyalgia

Science.gov (United States)

2014-01-01

Background No resilience scale has been validated in Spanish patients with fibromyalgia. The aim of this study was to evaluate the validity and reliability of the 10-item CD-RISC in a sample of Spanish patients with fibromyalgia. Methods Design: Observational prospective multicenter study. Sample: Patients with diagnoses of fibromyalgia recruited from primary care settings (N = 208). Instruments: In addition to sociodemographic data, the following questionnaires were administered: Pain Visual Analogue Scale (PVAS), the 10-item Connor-Davidson Resilience scale (10-item CD-RISC), the Fibromyalgia Impact Questionnaire (FIQ), the Hospital Anxiety and Depression Scale (HADS), the Pain Catastrophizing Scale (PCS), the Chronic Pain Acceptance Questionnaire (CPAQ), and the Mindful Attention Awareness Scale (MAAS). Results Regarding construct validity, the factor solution in the Principal Component Analysis (PCA) was considered adequate, so the KMO test had a value of 0.91, and the Barlett’s test of sphericity was significant (χ2 = 852.8; gl = 45; p fibromyalgia, acceptable psychometric properties, with a high level of reliability and validity. PMID:24484847

IBM SPSS modeler essentials effective techniques for building powerful data mining and predictive analytics solutions

CERN Document Server

McCormick, Keith; Wei, Bowen

2017-01-01

IBM SPSS Modeler allows quick, efficient predictive analytics and insight building from your data, and is a popularly used data mining tool. This book will guide you through the data mining process, and presents relevant statistical methods which are used to build predictive models and conduct other analytic tasks using IBM SPSS Modeler. From ...

Study of risc factors affecting the number of mental disorders and nervous system diseases for people who participated in liquidation of consequences of ChNPP accident

International Nuclear Information System (INIS)

Ivanov, V.K.; Chekin, S.Yu.; Mikhal'skij, A.I.; Petrovskij, A.M.

1992-01-01

Interrelation of disease incidence for liquidators and factors affecting it has been studied. The diseases (mental disorders and nervous system diseases) have been taken into account provided more than 10% of people have suffered of the above diseases. Date of getting into the accident zone; duration of work within the zone; the radiation dose accumulated were considered to be risc factors. Getting into the accident zone and duration of work within the zone of accident have been though to be the main risc factors. 3 figs.; 2 tabs

IBM parameters derived from realistic shell-model Hamiltonian via Hn-cooling method

International Nuclear Information System (INIS)

Nakada, Hitoshi

1997-01-01

There is a certain influence of non-collective degrees-of-freedom even in lowest-lying states of medium-heavy nuclei. This influence seems to be significant for some of the IBM parameters. In order to take it into account, several renormalization approaches have been applied. It has been shown in the previous studies that the influence of the G-pairs is important, but does not fully account for the fitted values. The influence of the non-collective components may be more serious when we take a realistic effective nucleonic interaction. To incorporate this influence into the IBM parameters, we employ the recently developed H n -cooling method. This method is applied to renormalize the wave functions of the states consisting of the SD-pairs, for the Cr-Fe nuclei. On this ground, the IBM Hamiltonian and transition operators are derived from corresponding realistic shell-model operators, for the Cr-Fe nuclei. Together with some features of the realistic interaction, the effects of the non-SD degrees-of-freedom are presented. (author)

IBM Sametime 852 Administration Guide

CERN Document Server

Davis, Gabriella; Duff, Thomas

2011-01-01

The IBM Lotus Sametime 8.5.2 Administration Guide uses a practical, no-nonsense approach to give you the essential information you need. Using realistic scenarios, you learn how to configure and maintain your environment to meet your needs and take advantage of the flexibility offered in Sametime 8.5.2. If you are responsible for installing and administering Sametime 8.5.2, then this book is for you. If you're completely new to Sametime administration, this book will serve as your roadmap. If you're making the jump from a prior version of Sametime, then you'll see how Sametime 8.5.2 differs an

An Apple for Your IBM PC--The Quadlink Board.

Science.gov (United States)

Owen, G. Scott

1984-01-01

Describes nature and installation of the QUADLINK board which allows Apple software to be run on IBM PC microcomputers. Although programs tested ran without problems, users should test their own programs since there are some copy protection schemes that can baffle the board. (JN)

Mathematics Programming on the Apple II and IBM PC.

Science.gov (United States)

Myers, Roy E.; Schneider, David I.

1987-01-01

Details the features of BASIC used in mathematics programming and provides the information needed to translate between the Apple II and IBM PC computers. Discusses inputing a user-defined function, setting scroll windows, displaying subscripts and exponents, variable names, mathematical characters and special symbols. (TW)

Transmissió vertical del virus de l'hepatitis C. Factors de risc, història natural dels nens infectats i evolució a llarg termini

OpenAIRE

Viñolas Tolosa, Maria

2016-01-01

Introducció: La TV del VHC succeeix en el 5-15% dels casos i depèn de factors de risc materns, obstètrics i neonatals. Fins el moment existeix poca informació sobre l’evolució dels nens infectats més enllà dels 2 o 3 primers anys de vida. L’objectiu del present estudi es determinar la taxa de TV, els factors de risc i l’evolució a llarg termini dels nens infectats. Pacients i mètodes: Estudi prospectiu de cohorts de 120 gestants infectades per VHC i els seus fills nascuts a l’Hospital del ...

The Little Giant: The IBM Series/1 in Library Applications.

Science.gov (United States)

Hendricks, Donald D.; Manino, Glenn

1987-01-01

This description of the use of IBM Series/1 minicomputers to implement a library automation system includes discussion of current functions of the system, the system configuration, communications capabilities, software, and cost factors. (CLB)

Vector and parallel computing on the IBM ES/3090, a powerful approach to solving problems in the utility industry

International Nuclear Information System (INIS)

Bellucci, V.J.

1990-01-01

This paper describes IBM's approach to parallel computing using the IBM ES/3090 computer. Parallel processing concepts were discussed including its advantages, potential performance improvements and limitations. Particular applications and capabilities for the IBM ES/3090 were presented along with preliminary results from some utilities in the application of parallel processing to simulation of system reliability, air pollution models, and power network dynamics

IBM PC based automatic drive system for Bulat setup

International Nuclear Information System (INIS)

Luchaninov, A.A.; Tolok, V.T.

1999-01-01

Non-expensive computer drive system for Bulat setup is described. System's hardware consists of IBM PC and conjunction block, providing 12 output channels, Software includes the main program, utilities and technology processes database. System may be used at surface modification processes, especially multilayer multicomponent coatings deposition

Performing data analysis using IBM SPSS

CERN Document Server

Meyers, Lawrence S; Guarino, A J

2013-01-01

This book is designed to be a user's guide for students and other interested readers to perform statistical data analysis with IBM SPSS, which is a major statistical software package used extensively in academic, government, and business settings. This book addresses the needs, level of sophistication, and interest in introductory statistical methodology on the part of undergraduate and graduate students in social and behavioral science, business, health-related, and education programs.  Each chapter covers a particular statistical procedure and has the following format: an example pr

Balanç benefici/risc del contingut en polifenols i alcohol del vi: bases científiques dels efectes del consum moderat de vi sobre el sistema cardiovascular

OpenAIRE

Chiva Blanch, Gemma

2013-01-01

[cat] L'objectiu d'aquesta tesi doctoral és avaluar els efectes de les fraccions del vi (alcohòlica i no alcohòlica -principalment polifenols-) sobre els principals factors de risc cardiovascular en 67 homes amb un elevat risc de patir malalties cardiovasculars. Es va realitzar un assaig clínic, aleatoritzat i creuat en el qual tots els participants van rebre en un ordre aleatori les tres intervencions: 30 gr d'alcohol / dia en forma de vi negre, la mateixa quantitat de polifenols en forma de...

Inference in media space. The case of IBM Software Executive Briefing Center - Rome

Directory of Open Access Journals (Sweden)

Toni Marino

2014-11-01

Full Text Available In our paper we apply Peirce's model of Arguments (Statistical Deduction, Probabilistic Deduction, Induction and Abduction to a communication process where negotiating sense and meanings is emphasized. We selected a communication space where everything is planned as a medium of sense (video terminals, screens, lights, etc. namely the IBM Software Executive Briefing Center in Italy, a workplace used to exchange views, negotiate or transact. It is based in Rome in the same building as the International Development Laboratory of the IBM Software Group. The Software Center is the place where IBM welcomes its potential customers and has the opportunity to show them its technology and offer solutions. This paper focuses on "media space" in the Center which is structured by the seller according to his/her idea of the buyer's interpretive process. This paper analyzes the roles of visual codes in the allocation of functions. It also looks into the relation between the symbolism of the company with its marketing, past history and media space in order to define the buyer's typology of inference (deduction, induction or abduction in relation to the communication strategy of the media space design. The research is conducted directly in the field by interviewing the Manager of the IBM Center as well as asking people who use it to fill in an anonymous questionnaire, which analyses both the media space and the plan of the building.

Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties

Energy Technology Data Exchange (ETDEWEB)

Lawrence, C.P. [Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester LE1 9HN (United Kingdom); Chow, S.C., E-mail: chow.sek.chuen@monash.edu [School of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, 46150 Selangor Darul Ehsan (Malaysia)

2012-11-15

The caspase inhibitors, benzyloxycarbony (Cbz)-l-Val-Ala-Asp (OMe)-fluoromethylketone (z-VAD-FMK) and benzyloxycarbonyl (Cbz)-Ile-Glu (OMe)-Thr-Asp (OMe)-FMK (z-IETD-FMK) at non-toxic doses were found to be immunosuppressive and inhibit human T cell proliferation induced by mitogens and IL-2 in vitro. Both caspase inhibitors were shown to block NF-κB in activated primary T cells, but have little inhibitory effect on the secretion of IL-2 and IFN-γ during T cell activation. However, the expression of IL-2 receptor α-chain (CD25) in activated T cells was inhibited by both z-VAD-FMK and z-IETD-FMK, whereas the expression of the early activated T cell marker, CD69 was unaffected. During primary T cell activation via the antigen receptor, both caspase-8 and caspase-3 were activated and processed to their respective subunits, but neither caspase inhibitors had any effect on the processing of these two caspases. In sharp contrast both caspase inhibitors readily blocked apoptosis and the activation of caspases during FasL-induced apoptosis in activated primary T cells and Jurkat T cells. Collectively, the results demonstrate that both z-VAD-FMK and z-IETD-FMK are immunosuppressive in vitro and inhibit T cell proliferation without blocking the processing of caspase-8 and caspase-3. -- Highlights: ► Caspase-8 and caspase-3 were activated during T cell activation and proliferation. ► T cell proliferation was blocked by caspase inhibitors. ► Caspase activation during T cell proliferation was not block by caspase inhibitors.

Software Process Improvement Journey: IBM Australia Application Management Services

Science.gov (United States)

2005-03-01

See Section 5.1.2) - Client Relationship Management ( CRM ) processes-specifically, Solution Design and Solution Delivery - Worldwide Project Management ...plex systems life-cycle management , rapid solutions development, custom development, package selection and implementation, maintenance, minor...CarnegieMellon ___ Software Engineering Institute Software Process Improvement Journey: IBM Australia Application Management Services Robyn Nichols

Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases.

Science.gov (United States)

Hernández, Armando R; Peterson, Larryn W; Kool, Eric T

2012-08-17

Understanding the interactions between small interfering RNAs (siRNAs) and the RNA-induced silencing complex (RISC), the key protein complex of RNA interference (RNAi), is of great importance to the development of siRNAs with improved biological and potentially therapeutic function. Although various chemically modified siRNAs have been reported, relatively few studies with modified nucleobases exist. Here we describe the synthesis and hybridization properties of siRNAs bearing size-expanded RNA (xRNA) nucleobases and their use as a novel and systematic set of steric probes in RNAi. xRNA nucleobases are expanded by 2.4 Å using benzo-homologation and retain canonical Watson-Crick base-pairing groups. Our data show that the modified siRNA duplexes display small changes in melting temperature (+1.4 to -5.0 °C); substitutions near the center are somewhat destabilizing to the RNA duplex, while substitutions near the ends are stabilizing. RNAi studies in a dual-reporter luciferase assay in HeLa cells revealed that xRNA nucleobases in the antisense strand reduce activity at some central positions near the seed region but are generally well tolerated near the ends. Most importantly, we observed that xRNA substitutions near the 3'-end increased activity over that of wild-type siRNAs. The data are analyzed in terms of site-dependent steric effects in RISC. Circular dichroism experiments show that single xRNA substitutions do not significantly distort the native A-form helical structure of the siRNA duplex, and serum stability studies demonstrated that xRNA substitutions protect siRNAs against nuclease degradation.

Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.

Science.gov (United States)

Kim, Bong Cho; Lee, Hyung Chul; Lee, Je-Jung; Choi, Chang-Min; Kim, Dong-Kwan; Lee, Jae Cheol; Ko, Young-Gyu; Lee, Jae-Seon

2012-11-14

Premature senescence, a key strategy used to suppress carcinogenesis, can be driven by p53/p21 proteins in response to various stresses. Here, we demonstrate that Wig1 plays a critical role in this process through regulation of p21 mRNA stability. Wig1 controls the association of Argonaute2 (Ago2), a central component of the RNA-induced silencing complex (RISC), with target p21 mRNA via binding of the stem-loop structure near the microRNA (miRNA) target site. Depletion of Wig1 prohibited miRNA-mediated p21 mRNA decay and resulted in premature senescence. Wig1 plays an essential role in cell proliferation, as demonstrated in tumour xenografts in mice, and Wig1 and p21 mRNA levels are inversely correlated in human normal and cancer tissues. Together, our data indicate a novel role of Wig1 in RISC target accessibility, which is a key step in RNA-mediated gene silencing. In addition, these findings indicate that fine-tuning of p21 levels by Wig1 is essential for the prevention of cellular senescence.

IBM SPSS statistics 19 made simple

CERN Document Server

Gray, Colin D

2012-01-01

This new edition of one of the most widely read textbooks in its field introduces the reader to data analysis with the most powerful and versatile statistical package on the market: IBM SPSS Statistics 19. Each new release of SPSS Statistics features new options and other improvements. There remains a core of fundamental operating principles and techniques which have continued to apply to all releases issued in recent years and have been proved to be worth communicating in a small volume. This practical and informal book combines simplicity and clarity of presentation with a comprehensive trea

Maintenance of Microcomputers. Manual and Apple II Session, IBM Session.

Science.gov (United States)

Coffey, Michael A.; And Others

This guide describes maintenance procedures for IBM and Apple personal computers, provides information on detecting and diagnosing problems, and details diagnostic programs. Included are discussions of printers, terminals, disks, disk drives, keyboards, hardware, and software. The text is supplemented by various diagrams. (EW)

The algebraic manipulation program DIRAC on IBM personal computers

International Nuclear Information System (INIS)

Grozin, A.G.; Perlt, H.

1989-01-01

The version DIRAC (2.2) for IBM compatible personal computers is described. It is designed to manipulate algebraically with polynomials and tensors. After a short introduction concerning implementation and usage on personal computers an example program is given. It contains a detailed user's guide to DIRAC (2.2) and, additionally some useful applications. 4 refs

Design of a 1-chip IBM-3270 protocol handler

NARCIS (Netherlands)

Spaanenburg, L.

1989-01-01

The single-chip design of a 20MHz IBM-3270 coax protocol handler in a conventional 3 μ CMOS process-technology is discussed. The harmonious combination of CMOS circuit tricks and high-level design disciplines allows the 50k transistor design to be compiled and optimized into a 35 mm**2 chip in 4

Data transfer from Beckman LS 5800 liquid scintillation counters to IBM personal computers.

Science.gov (United States)

Maan, A C

1985-09-01

This communication describes a short routine in BASICA for the IBM-PC, written to collect data from a Beckman liquid scintillation counter. In the form presented here the routine converts incoming bytes into separate lines and saves these lines in a file. There are many possible applications for further use of the data in these files. A few suggestions are given as to the format in which data can be stored and how to process these data automatically after all samples have been counted. The only hardware needed is an asynchronous communications adapter for the IBM-PC and an RS232 cable.

A tale of two arcs? Plate tectonics of the Izu-Bonin-Mariana (IBM) arc using subducted slab constraints

Science.gov (United States)

Wu, J. E.; Suppe, J.; Renqi, L.; Kanda, R. V. S.

2014-12-01

Published plate reconstructions typically show the Izu-Bonin Marianas arc (IBM) forming as a result of long-lived ~50 Ma Pacific subduction beneath the Philippine Sea. These reconstructions rely on the critical assumption that the Philippine Sea was continuously coupled to the Pacific during the lifetime of the IBM arc. Because of this assumption, significant (up to 1500 km) Pacific trench retreat is required to accommodate the 2000 km of Philippine Sea/IBM northward motion since the Eocene that is constrained by paleomagnetic data. In this study, we have mapped subducted slabs of mantle lithosphere from MITP08 global seismic tomography (Li et al., 2008) and restored them to a model Earth surface to constrain plate tectonic reconstructions. Here we present two subducted slab constraints that call into question current IBM arc reconstructions: 1) The northern and central Marianas slabs form a sub-vertical 'slab wall' down to maximum 1500 km depths in the lower mantle. This slab geometry is best explained by a near-stationary Marianas trench that has remained +/- 250 km E-W of its present-day position since ~45 Ma, and does not support any significant Pacific slab retreat. 2) A vanished ocean is revealed by an extensive swath of sub-horizontal slabs at 700 to 1000 km depths in the lower mantle below present-day Philippine Sea to Papua New Guinea. We call this vanished ocean the 'East Asian Sea'. When placed in an Eocene plate reconstruction, the East Asian Sea fits west of the reconstructed Marianas Pacific trench position and north of the Philippine Sea plate. This implies that the Philippine Sea and Pacific were not adjacent at IBM initiation, but were in fact separated by a lost ocean. Here we propose a new IBM arc reconstruction constrained by subducted slabs mapped under East Asia. At ~50 Ma, the present-day IBM arc initiated at equatorial latitudes from East Asian Sea subduction below the Philippine Sea. A separate arc was formed from Pacific subduction below

IbM Kelompok Usaha Produk Olahan Susu Segar Di Dusun Boyong Desa Hargobinangun, Sleman Yogyakarta

OpenAIRE

Rahayu, Ninik Sri; Indrawati, Sri

2014-01-01

Micro, IBM's partner program (science and technology to the Community) are SMEs Heroine Boyong I (stick milk) and Heroine Boyong II (milk candy). Both are micro-scale industry based on fresh dairy product businesses.IBM program on SME partners focused on the aspects of production and management. All activities in the production aspect functioned to improve the capacity and quality of production and increase dairy product variants. While aspects of management consists of: marketing, financial ...

RISC-KIT: Resilience-increasing Strategies for Coasts

Directory of Open Access Journals (Sweden)

van Dongeren Ap

2016-01-01

Full Text Available High-impact storm events have demonstrated the vulnerability of coastal zones in Europe and beyond. These impacts are likely to increase due to predicted climate change and ongoing coastal development. In order to reduce impacts, disaster risk reduction (DRR measures need to be taken, which prevent or mitigate the effects of storm events. To drive the DRR agenda, the UNISDR formulated the Sendai Framework for Action, and the EU has issued the Floods Directive. However, neither is specific about the methods to be used to develop actionable DRR measures in the coastal zone. Therefore, there is a need to develop methods, tools and approaches which make it possible to: identify and prioritize the coastal zones which are most at risk through a Coastal Risk Assessment Framework, and to evaluate the effectiveness of DRR options for these coastal areas, using an Early Warning/Decision Support System, which can be used both in the planning and event-phase. This paper gives an overview of the products and results obtained in the FP7-funded project RISC-KIT, which aims to develop and apply a set of tools with which highly-vulnerable coastal areas (so-called “hotspots” can be identified.

An IBM-3 hamiltonian from a multi-j-shell model

International Nuclear Information System (INIS)

Evans, J.A.; Elliott, J.P.; Lac, V.S.; Long, G.L.

1995-01-01

The number and isospin dependence of the hamiltonian in the isospin invariant form (IBM-3) of the boson model is deduced from a seniority mapping onto a shell-model system of several shells. The numerical results are compared with earlier work for a single j-shell. (orig.)

A RISC multiprocessor event trigger for the data acquisition system of the H1 experiment at HERA

International Nuclear Information System (INIS)

Campbell, A.J.

1992-01-01

In late 1991 HERA will collide for the first time stored beams of electrons and protons. This paper describes the multiple RISC processor system for online event filtering and reconstruction installed within the data acquisition system of the H1 experiment. Data is processed at a continuous average rate of ∼6 Mbytes/s in parallel by ∼20 R3000 VMEbus based monoboard computers providing some 400 MIPS computing power

Multi drop bus controller for IBM PC/AT

International Nuclear Information System (INIS)

Bardik, Yu.I.; Kalistratov, E.N.; Matyushin, A.A.; Obukhov, G.A.; Trofimov, N.N.

1993-01-01

The module PC-AT-PBC gives a possibility to create a working place based on the computer IBM PC/AT for testing of hardware which is compatible with the multi drop bus. The KP1830BE31 micro program change turns the module into timing generator for power supply controllers of the UNK correction system. The structure of the module, functional parts, library functions and two application programs have been described. 4 refs., 9 figs

Design of multichannel counting system-2 for IBM PC and compatibles

International Nuclear Information System (INIS)

Ahmad, Z.; Qamer, R.; Mushtaq, N.

2001-04-01

A multichannel, Counting System 2 (MCCS-2) data acquisition plug-in card for the IBM ISA, MCA and EISA bus architecture has been designed and developed for acquisition of pulsed signal. The card features large dynamic range is achieved with the help of 16-bit pulse counters, fast signal acquisition and a self-testing capability in a single slot card. The MCCS-2 (designed by R and D group, CD) is an upgraded version of MCCS-1 [6]. The MCCS-2 consists of a plug-in interface card (MCCS-PC) for IBM PC and compatibles and a BNC terminal module (MCCS-BNC). The MCCS-PC is address selectable and can simultaneous monitoring ten independent SCA inputs. An on board programmable timer provides elapsed time measurement. A menu-driven software program is developed for data acquisition and timer control. (author)

Using IBMs to Investigate Spatially-dependent Processes in Landscape Genetics Theory

Science.gov (United States)

Much of landscape and conservation genetics theory has been derived using non-spatialmathematical models. Here, we use a mechanistic, spatially-explicit, eco-evolutionary IBM to examine the utility of this theoretical framework in landscapes with spatial structure. Our analysis...

Generalized Information Architecture for Managing Requirements in IBM?s Rational DOORS(r) Application.

Energy Technology Data Exchange (ETDEWEB)

Aragon, Kathryn M.; Eaton, Shelley M.; McCornack, Marjorie Turner; Shannon, Sharon A.

2014-12-01

When a requirements engineering effort fails to meet expectations, often times the requirements management tool is blamed. Working with numerous project teams at Sandia National Laboratories over the last fifteen years has shown us that the tool is rarely the culprit; usually it is the lack of a viable information architecture with well- designed processes to support requirements engineering. This document illustrates design concepts with rationale, as well as a proven information architecture to structure and manage information in support of requirements engineering activities for any size or type of project. This generalized information architecture is specific to IBM's Rational DOORS (Dynamic Object Oriented Requirements System) software application, which is the requirements management tool in Sandia's CEE (Common Engineering Environment). This generalized information architecture can be used as presented or as a foundation for designing a tailored information architecture for project-specific needs. It may also be tailored for another software tool. Version 1.0 4 November 201

Configuration control plan for the ports NCS IBM RS/6000

International Nuclear Information System (INIS)

Brown, A.S.

1996-01-01

This document describes the actions and responsibilities for maintaining the quality and integrity of the NS software resident on the IBM RS/6000 workstation managed by the Nuclear Criticality Safety group at the Portsmouth Gaseous Diffusion Plant. This document does not address the validation of NS software packages for the RS/6000

Efficient Ada multitasking on a RISC register window architecture

Science.gov (United States)

Kearns, J. P.; Quammen, D.

1987-01-01

This work addresses the problem of reducing context switch overhead on a processor which supports a large register file - a register file much like that which is part of the Berkeley RISC processors and several other emerging architectures (which are not necessarily reduced instruction set machines in the purest sense). Such a reduction in overhead is particularly desirable in a real-time embedded application, in which task-to-task context switch overhead may result in failure to meet crucial deadlines. A storage management technique by which a context switch may be implemented as cheaply as a procedure call is presented. The essence of this technique is the avoidance of the save/restore of registers on the context switch. This is achieved through analysis of the static source text of an Ada tasking program. Information gained during that analysis directs the optimized storage management strategy for that program at run time. A formal verification of the technique in terms of an operational control model and an evaluation of the technique's performance via simulations driven by synthetic Ada program traces are presented.

IBM Industry Practice: Challenges in Offshore Software Development from a Global Delivery Center

Science.gov (United States)

Musio, Ilario

Offshore software development has greatly influenced competitiveness among IT companies in the last decade. Despite the fact that there are matured and developed offshoring methodologies, there is an ongoing tendency to look for new ways of improving them. Major IT corporations successfully rely on their offshore delivery centers for bridging the gap between communication and infrastructure boundaries. However, projects tend to fail, so problems have to be considered that arise between on- and offshore parts within the same corporation. Based on seven case studies from the industry, this paper describes experiences and challenges faced during the execution of offshore application development between IBM Switzerland and IBM India. Additionally, approaches on how they can be solved are proposed.

International Business Machines (IBM) Corporation Interim Agreement EPA Case No. 08-0113-00

Science.gov (United States)

On March 27, 2008, the United States Environmental Protection Agency (EPA), suspended International Business Machines (IBM) from receiving Federal Contracts, approved subcontracts, assistance, loans and other benefits.

Application of specialized RISC processor for realization of algorithms for track signal filtration on data read from CCD

International Nuclear Information System (INIS)

Ban, Ya.; Kotov, V.M.; Kharcharufkova, K.

1987-01-01

Algorithms for track signal filtration from bubble and streamer spark chambers read by CCD matrix with elements of 256x288 dimensions are described. The microprogrammed RISC processor is used for preliminary processing and filtration of data obtained. It makes possible to recognize and filter track elements in the zone of 0.25 mm 2 square during 0.17-0.20 s, that maintains it in real time operation

Informatīva uzņēmuma vadības sistēma

OpenAIRE

Salzemnieks, Aldis

2009-01-01

Informatīva uzņēmuma vadības sistēma piedāvā ērti un ātri pārlūkot informāciju par darbiniekiem, klientiem un finansiālajām attiecībām pret klientiem, kontrolēt uzņēmuma darbinieku veiktās darbības un veiksmīgi sadalīt darbus starp darbiniekiem. Sistēmu iespējams uzstādīt tā, lai piekļuve tai caur pārlūkprogrammu būtu gan no iekšējā datortīklā, gan arī tīmeklī. Tas nodrošina ātru, kvalitatīvu un organizētu darba izpildi, kā arī ietaupa laiku. Sistēmā iespējams izveidot lietotājus ar dažādiem ...

Neutron cross section measurement using the Oak Ridge Electron Linear Accelerator

International Nuclear Information System (INIS)

Winters, R.R.

1991-08-01

This report discusses: argon-40 -- neutron reaction total cross sections from 6.9 kev to 50 kev; The maxwellian averaged neutron capture cross section of oxygen-16; r-matrix parameter analysis of the lead-208 -- neutron reaction cross section measurement; r-matrix parameter analysis of the ORELA neutron transmission zirconium-90 low energy measurement; porting computer codes from the HP9000 to the IBM RISC/6000;and measurements of neutron reactions with strontium-88, zirconium-90, and calcium-40

An IBM 370 assembly language program verifier

Science.gov (United States)

Maurer, W. D.

1977-01-01

The paper describes a program written in SNOBOL which verifies the correctness of programs written in assembly language for the IBM 360 and 370 series of computers. The motivation for using assembly language as a source language for a program verifier was the realization that many errors in programs are caused by misunderstanding or ignorance of the characteristics of specific computers. The proof of correctness of a program written in assembly language must take these characteristics into account. The program has been compiled and is currently running at the Center for Academic and Administrative Computing of The George Washington University.

A RISC multiprocessor event trigger for the data acquisition system of the H1 experiment at HERA

International Nuclear Information System (INIS)

Campbell, A.J.

1991-09-01

In late 1991 HERA will for the first time collide stored beams of electrons and protons. This paper describes the multiple (RISC) modern reduced instruction set processor system for online event filtering and reconstruction installed within the data acquisition system of the H1 experiment. Data is processed at a continuous average rate of ∼ 6 Mbytes/s in parallel by ∼ 20 R3000 VMEbus based monoboard computers providing some 400 mips computing power. (author)

Integrating Closed-loop Supply Chains and Spare Parts Management at IBM

NARCIS (Netherlands)

M. Fleischmann (Moritz); J.A.E.E. van Nunen (Jo); B. Graeve

2002-01-01

textabstractEver more companies are recognizing the benefits of closed-loop supply chains that integrate product returns into business operations. IBM has been among the pioneers seeking to unlock the value dormant in these resources. We report on a project exploiting product returns as a source of

Programming the Linpack Benchmark for the IBM PowerXCell 8i Processor

Directory of Open Access Journals (Sweden)

Michael Kistler

2009-01-01

Full Text Available In this paper we present the design and implementation of the Linpack benchmark for the IBM BladeCenter QS22, which incorporates two IBM PowerXCell 8i1 processors. The PowerXCell 8i is a new implementation of the Cell Broadband Engine™2 architecture and contains a set of special-purpose processing cores known as Synergistic Processing Elements (SPEs. The SPEs can be used as computational accelerators to augment the main PowerPC processor. The added computational capability of the SPEs results in a peak double precision floating point capability of 108.8 GFLOPS. We explain how we modified the standard open source implementation of Linpack to accelerate key computational kernels using the SPEs of the PowerXCell 8i processors. We describe in detail the implementation and performance of the computational kernels and also explain how we employed the SPEs for high-speed data movement and reformatting. The result of these modifications is a Linpack benchmark optimized for the IBM PowerXCell 8i processor that achieves 170.7 GFLOPS on a BladeCenter QS22 with 32 GB of DDR2 SDRAM memory. Our implementation of Linpack also supports clusters of QS22s, and was used to achieve a result of 11.1 TFLOPS on a cluster of 84 QS22 blades. We compare our results on a single BladeCenter QS22 with the base Linpack implementation without SPE acceleration to illustrate the benefits of our optimizations.

Reliability and validity of the Khmer version of the 10-item Connor-Davidson Resilience Scale (Kh-CD-RISC10) in Cambodian adolescents.

Science.gov (United States)

Duong, Chanmettachampavieng; Hurst, Cameron P

2016-06-08

Resilience has been characterized as a defensive factor against the refinement of mental health problems. This study adapted the Connor-Davidson Resilience Scale (Kh-CD-RISC10) for use in Khmer adolescents and subsequently investigates its psychometric properties. Using stratified random sampling, this cross-sectional study sampled Cambodian adolescents from high schools selected randomly within three provinces (Phnom Penh, Battambang and Mondulkiri)-location (rural, urban) combinations. Parallel analysis was used to identify the number of component(s), and the structure of the single factor was subsequently explored using principal axis factoring. A confirmatory factor analysis was then performed to establish the fit of the Kh-CD-RISC10 to another sample. To assess convergent validity, the factor scores of the Khmer version of Connor-Davidson Resilience Scale were categorized into three levels, and then the general negative affectivity (GNA) and physiological hyperarousal (PH) scales (derived from the DASS 21) were compared among the three resilience groups. Of the 798 participants who responded (responded rate = 82.26 %), 440 (41.23 %) were female and the age ranged from 14 to 24 years old (mean = 17.36, SD = 1.325). The internal consistency of the Khmer 10-item CD-RISC was also shown to be high in Cambodian adolescents (Cronbach's alpha = 0. 82). Confirmatory factor analysis revealed the single factor model fit data adequately (χ(2) = 100.103, df = 35, p scale of this population, and can be used to assess the resilience comparing to the level of PTSD symptoms in general Khmer adolescent.

Integrated Tiger Series of electron/photon Monte Carlo transport codes: a user's guide for use on IBM mainframes

International Nuclear Information System (INIS)

Kirk, B.L.

1985-12-01

The ITS (Integrated Tiger Series) Monte Carlo code package developed at Sandia National Laboratories and distributed as CCC-467/ITS by the Radiation Shielding Information Center (RSIC) at Oak Ridge National Laboratory (ORNL) consists of eight codes - the standard codes, TIGER, CYLTRAN, ACCEPT; the P-codes, TIGERP, CYLTRANP, ACCEPTP; and the M-codes ACCEPTM, CYLTRANM. The codes have been adapted to run on the IBM 3081, VAX 11/780, CDC-7600, and Cray 1 with the use of the update emulator UPEML. This manual should serve as a guide to a user running the codes on IBM computers having 370 architecture. The cases listed were tested on the IBM 3033, under the MVS operating system using the VS Fortran Level 1.3.1 compiler

Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study

DEFF Research Database (Denmark)

Bot, M; Pouwer, F; De Jonge, P

2013-01-01

Sensitivity and Cardiovascular Disease Risk (RISC) study. Presence of significant depressive symptoms was defined as a Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16. Standard oral glucose tolerance tests were performed. Insulin sensitivity was assessed with the oral glucose insulin......AIM: This study explored the association of depressive symptoms with indices of insulin sensitivity and insulin secretion in a cohort of non-diabetic men and women aged 30 to 64 years. METHODS: The study population was derived from the 3-year follow-up of the Relationship between Insulin...... sensitivity (OGIS) index. Insulin secretion was estimated using three model-based parameters of insulin secretion (beta-cell glucose sensitivity, the potentiation factor ratio, and beta-cell rate sensitivity). RESULTS: A total of 162 out of 1027 participants (16%) had significant depressive symptoms. Having...

User's manual for levelized power generation cost using an IBM PC

International Nuclear Information System (INIS)

Fuller, L.C.

1985-06-01

Programs for the estimation of levelized electric power generation costs using the BASIC interpreter on an IBM PC are described. Procedures for light-water reactor plants and coal-fired plants include capital investment cost, operation and maintenance cost, fuel cycle cost, nuclear decommissioning cost, and levelized total generation cost

Multifunction input-output board for the IBM AT/XT (Lab-Master)

Energy Technology Data Exchange (ETDEWEB)

Pilyar, A V

1996-12-31

Multifunction input-output board for the IBM PC AT/XT is described. It consists of a CMOS analog input multiplexer, programmable amplifier, a fast 12-bit ADC, four 10-bit DAC and two 8-bit digital input-output registers. Specifications of analog input and output are given. 6 refs.

Centro de cálculo IBM - Francfort (Alemania Federal

Directory of Open Access Journals (Sweden)

Apel, Beckert, Becker, Arquitectos

1972-03-01

Full Text Available This centre comprises a tall building, of approximately square cross section, and a 10 m high rectangular block. The first one houses the offices, and the second contains an IBM computer and accessories. The structure is of reinforced concrete for the vertical members, and ribbed flooring slabs for the horizontal ones. The external enclosing medium consists of precast concrete elements, and large glazed surfaces. The are features of ornamental significance, such as the indoor helicoidal stairs of unfaced concrete, and the slab covered square, with its garden and artificial lake areas. Parking space is provided in the basements.El complejo se compone de: — un rascacielos con planta sensiblemente cuadrada y 38 m de altura, y — un bloque rectangular, más bajo, de 9,90 m de alto. El primero alberga las oficinas, y el segundo se destina a cubrir todas las exigencias que se derivan del funcionamiento de un ordenador IBM. Su estructura, a base de núcleos verticales de hormigón armado, forjados nervados y cerramientos compuestos de piezas de hormigón, prefabricadas, con grandes zonas acristaladas. Hay motivos ornamentales, como la escalera helicoidal interior, de hormigón visto, y la plaza enlosada, con estanques y jardineras. Aparcamiento en el sótano.

George E. Pake Prize Lecture: Physical Sciences Research at IBM: Still at the Cutting Edge

Science.gov (United States)

Theis, Thomas

2015-03-01

The information technology revolution is in its ``build out'' phase. The foundational scientific insights and hardware inventions are now many decades old. The microelectronics industry is maturing. An increasing fraction of the total research investment is in software and services, as applications of information technology transform every business and every sector of the public and private economy. Yet IBM Research continues to make substantial investments in hardware technology and the underlying physical sciences. While some of this investment is aimed at extending the established transistor technology, an increasing fraction is aimed at longer-term and possibly disruptive research - new devices for computing, such as tunneling field-effect transistors and nanophotonic circuits, and new architectures, such as neurosynaptic systems and quantum computing. This research investment is a bet that the old foundations of information technology are ripe for reinvention. After all, today's information technology devices and systems operate far from any fundamental limits on speed and energy efficiency. But how can IBM make risky long-term research investments in an era of global competition, with financial markets focused on the short term? One important answer is partnerships. Since its early days, IBM Research has pursued innovation in information technology and innovation in the ways it conducts the business of research. By continuously evolving new models for research and development partnerships, it has extended its global reach, increased its impact on IBM's customers, and expanded the breadth and depth of its research project portfolio. Research in the physical sciences has often led the way. Currently on assignment to the Semiconductor Research Corporation.

International Border Management Systems (IBMS) Program : visions and strategies.

Energy Technology Data Exchange (ETDEWEB)

McDaniel, Michael; Mohagheghi, Amir Hossein

2011-02-01

Sandia National Laboratories (SNL), International Border Management Systems (IBMS) Program is working to establish a long-term border security strategy with United States Central Command (CENTCOM). Efforts are being made to synthesize border security capabilities and technologies maintained at the Laboratories, and coordinate with subject matter expertise from both the New Mexico and California offices. The vision for SNL is to provide science and technology support for international projects and engagements on border security.

Screening for markers of frailty and perceived risk of adverse outcomes using the Risk Instrument for Screening in the Community (RISC).

LENUS (Irish Health Repository)

O Caoimh, Rónán

2014-09-19

Functional decline and frailty are common in community dwelling older adults, increasing the risk of adverse outcomes. Given this, we investigated the prevalence of frailty-associated risk factors and their distribution according to the severity of perceived risk in a cohort of community dwelling older adults, using the Risk Instrument for Screening in the Community (RISC).

Low cost RISC implementation of intelligent ultra fast charger for Ni-Cd battery

International Nuclear Information System (INIS)

Petchjatuporn, Panom; Sirisuk, Phaophak; Khaehintung, Noppadol; Sunat, Khamron; Wicheanchote, Phinyo; Kiranon, Wiwat

2008-01-01

This paper presents a low cost reduced instruction set computer (RISC) implementation of an intelligent ultra fast charger for a nickel-cadmium (Ni-Cd) battery. The charger employs a genetic algorithm (GA) trained generalized regression neural network (GRNN) as a key to ultra fast charging while avoiding battery damage. The tradeoff between mean square error (MSE) and the computational burden of the GRNN is addressed. Besides, an efficient technique is proposed for estimation of a radial basis function (RBF) in the GRNN. Hardware realization based upon the techniques is discussed. Experimental results with commercial Ni-Cd batteries reveal that while the proposed charger significantly reduces the charging time, it scarcely deteriorates the battery energy storage capability when compared with the conventional charger

Low cost RISC implementation of intelligent ultra fast charger for Ni-Cd battery

Energy Technology Data Exchange (ETDEWEB)

Petchjatuporn, Panom; Khaehintung, Noppadol [Department of Control and Instrumentation Engineering, Faculty of Engineering, Mahanakorn University of Technology, Bangkok 10530 (Thailand); Sirisuk, Phaophak; Sunat, Khamron [Department of Computer Engineering, Faculty of Engineering, Mahanakorn University of Technology, Bangkok 10530 (Thailand); Wicheanchote, Phinyo [Test Engineering Department, Sanmina-SCI Systems Co. Ltd. (Thailand); Kiranon, Wiwat [Department of Telecommunication Engineering, Faculty of Engineering, King Mongkut' s Institue of Technology, Ladkrabang, Bangkok 10520 (Thailand)

2008-02-15

This paper presents a low cost reduced instruction set computer (RISC) implementation of an intelligent ultra fast charger for a nickel-cadmium (Ni-Cd) battery. The charger employs a genetic algorithm (GA) trained generalized regression neural network (GRNN) as a key to ultra fast charging while avoiding battery damage. The tradeoff between mean square error (MSE) and the computational burden of the GRNN is addressed. Besides, an efficient technique is proposed for estimation of a radial basis function (RBF) in the GRNN. Hardware realization based upon the techniques is discussed. Experimental results with commercial Ni-Cd batteries reveal that while the proposed charger significantly reduces the charging time, it scarcely deteriorates the battery energy storage capability when compared with the conventional charger. (author)

A Method for Transferring Photoelectric Photometry Data from Apple II+ to IBM PC

Science.gov (United States)

Powell, Harry D.; Miller, James R.; Stephenson, Kipp

1989-06-01

A method is presented for transferring photoelectric photometry data files from an Apple II computer to an IBM PC computer in a form which is compatible with the AAVSO Photoelectric Photometry data collection process.

High Resolution Displays In The Apple Macintosh And IBM PC Environments

Science.gov (United States)

Winegarden, Steven

1989-07-01

High resolution displays are one of the key elements that distinguish user oriented document finishing or publishing stations. A number of factors have been involved in bringing these to the desktop environment. At Sigma Designs we have concentrated on enhancing the capabilites of IBM PCs and compatibles and Apple Macintosh computer systems.

A viral suppressor of RNA silencing inhibits ARGONAUTE 1 function by precluding target RNA binding to pre-assembled RISC.

Science.gov (United States)

Kenesi, Erzsébet; Carbonell, Alberto; Lózsa, Rita; Vértessy, Beáta; Lakatos, Lóránt

2017-07-27

In most eukaryotes, RNA silencing is an adaptive immune system regulating key biological processes including antiviral defense. To evade this response, viruses of plants, worms and insects have evolved viral suppressors of RNA silencing proteins (VSRs). Various VSRs, such as P1 from Sweet potato mild mottle virus (SPMMV), inhibit the activity of RNA-induced silencing complexes (RISCs) including an ARGONAUTE (AGO) protein loaded with a small RNA. However, the specific mechanisms explaining this class of inhibition are unknown. Here, we show that SPMMV P1 interacts with AGO1 and AGO2 from Arabidopsis thaliana, but solely interferes with AGO1 function. Moreover, a mutational analysis of a newly identified zinc finger domain in P1 revealed that this domain could represent an effector domain as it is required for P1 suppressor activity but not for AGO1 binding. Finally, a comparative analysis of the target RNA binding capacity of AGO1 in the presence of wild-type or suppressor-defective P1 forms revealed that P1 blocks target RNA binding to AGO1. Our results describe the negative regulation of RISC, the small RNA containing molecular machine. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Low-cost general purpose spectral display unit using an IBM PC

International Nuclear Information System (INIS)

Robinson, S.L.

1985-10-01

Many physics experiments require acquisition and analysis of spectral data. commercial minicomputer-based multichannel analyzers collect detected counts at various energies, create a histogram of the counts in memory, and display the resultant spectra. They acquire data and provide the user-to-display interface. The system discussed separates functions into the three modular components of data acquisition, storage, and display. This decoupling of functions allows the experimenter to use any number of detectors for data collection before forwarding up to 64 spectra to the display unit, thereby increasing data throughput over that available with commercial systems. An IBM PC was chosen for the low-cost, general purpose display unit. Up to four spectra may be displayed simultaneously in different colors. The histogram saves 1024 channels per detector, 640 of which may be distinctly displayed per spectra. The IEEE-488 standard provides the data path between the IBM PC and the data collection unit. Data is sent to the PC under interrupt control, using direct memory access. Display manipulations available via keyboard are also discussed

Study on ground state energy band of even 114-124Cd isotopes under the framework of interacting boson model (IBM-1)

International Nuclear Information System (INIS)

Hossain, I.; Abdullah, Hewa Y.; Ahmed, I.M.; Saeed, M.A.; Ahmad, S.T.

2012-01-01

In this research, the ground state gamma ray bands of even 114-124 Cd isotopes are calculated using interacting boson model (IBM-1). The theoretical energy levels for Z = 48, N = 66–76 up to spin-parity 8 + have been obtained by using PHINT computer program. The values of the parameters in the IBM-1 Hamiltonian yield the best fit to the experimental energy spectrum. The calculated results of the ground state energy band are compared to the previous experimental results and the obtained theoretical calculations in IBM-1 are in good agreement with the experimental energy level. (author)

Transfer of numeric ASCII data files between Apple and IBM personal computers.

Science.gov (United States)

Allan, R W; Bermejo, R; Houben, D

1986-01-01

Listings for programs designed to transfer numeric ASCII data files between Apple and IBM personal computers are provided with accompanying descriptions of how the software operates. Details of the hardware used are also given. The programs may be easily adapted for transferring data between other microcomputers.

PUBG; purex solvent extraction process model. [IBM3033; CDC CYBER175; FORTRAN IV

Energy Technology Data Exchange (ETDEWEB)

Geldard, J.F.; Beyerlein, A.L.

PUBG is a chemical model of the Purex solvent extraction system, by which plutonium and uranium are recovered from spent nuclear fuel rods. The system comprises a number of mixer-settler banks. This discrete stage structure is the basis of the algorithms used in PUBG. The stages are connected to provide for countercurrent flow of the aqueous and organic phases. PUBG uses the common convention that has the aqueous phase enter at the lowest numbered stage and exit at the highest one; the organic phase flows oppositely. The volumes of the mixers are smaller than those of the settlers. The mixers generate a fine dispersion of one phase in the other. The high interfacial area is intended to provide for rapid mass transfer of the plutonium and uranium from one phase to the other. The separation of this dispersion back into the two phases occurs in the settlers. The species considered by PUBG are Hydrogen (1+), Plutonium (4+), Uranyl Oxide (2+), Plutonium (3+), Nitrate Anion, and reductant in the aqueous phase and Hydrogen (1+), Uranyl Oxide (2+), Plutonium (4+), and TBP (tri-n-butylphosphate) in the organic phase. The reductant used in the Purex process is either Uranium (4+) or HAN (hydroxylamine nitrate).IBM3033;CDC CYBER175; FORTRAN IV; OS/MVS or OS/MVT (IBM3033), NOS 1.3 (CDC CYBER175); The IBM3033 version requires 150K bytes of memory for execution; 62,000 (octal) words are required by the CDC CYBER175 version..

Pengembangan Sistem Informasi Geografis Berbasis Node.JS untuk Pemetaan Mesin dan Tracking Engineer dengan Pemanfaatan Geolocation pada PT IBM Indonesia

Directory of Open Access Journals (Sweden)

RACHMAT FAJRIN

2017-09-01

Full Text Available PT IBM memiliki banyak klien di Indonesia, ini membuat persebaran produk (dalam hal ini mesin atm yang semakin meluas di wilayah Indonesia. Hal ini memicu PT IBM untuk menempatkan engineer dibanyak wilayah untuk memenuhi kebutuhan services dan maintenance. Untuk itu dalam penelitian ini dikembangkan sebuah sistem informasi geografis untuk pemetaan mesin dan tracking engineer dengan pemanfaatan geolocation yang bertujuan untuk menampilkan peta digital beserta lokasi mesin dan engineer di seluruh Indonesia, yang akan memudahkan PT IBM dalam pemberian tugas kepada engineer untuk services dan maintenance ke lokasi mesin terdekat. Sistem ini dibangun menggunakan beberapa software open source yaitu, Node.JS dan Express.JS yang merupakan server-side javascript web platform, Handlebars untuk template engine, MySQL sebagai database storage, Postman yang berfungsi sebagai API (Application Program Interface testing, Google Maps API untuk implementasi peta digital dan juga Firebase Cloud Messaging (FCM untuk platform mengirim notifikasi dari web ke device engineer.Pengembangan Sistem Informasi Geografis Berbasis Node.JS untuk Pemetaan Mesin dan Tracking Engineer dengan Pemanfaatan Geolocation pada PT IBM Indonesia

Nuclear facilities maintenance in the core of management-advanced trend in IBM Maximo asset management applications

International Nuclear Information System (INIS)

Seino, Satoshi; Ujihara, Satoshi; Kikuyama, Kaoru

2009-01-01

European and US plant owners have attached importance to plant maintenance, such as prompt grasp of plant states, implementation of maintenance and planning of maintenance programs, as one of asset management. The US advanced trend was introduced in this feature article through the applications of IBM Maximo Asset Management for nuclear facilities maintenance. World trends of nuclear power and related problems, need of nuclear facilities management, key items for introduction of maintenance management systems, required systems for nuclear maintenance management and introduction of functions of the IBM strategic asset management solution-Maximo were described respectively. (T. Tanaka)

PC-Link historical data base system MODCOMP/IBM at link for neutral particle beam operation

International Nuclear Information System (INIS)

Thurgood, P.

1989-01-01

PC-Link is a combination of hardware and software that connects an IBM PC/AT to a MODCOMP minicomputer. It is designed as an aid to the Neutral Beam operations coordinator during injection into the DIII-D tokamak project. An IBM PC/AT is linked to 4 MODCOMP realtime acquisition systems, each of which controls 2 neutral particle beam sources. At various points in the shot sequence, data is sent to the IBM PC/AT. This data can then be integrated with the data from the other sources into tables or graphics displays for use by the Beam Coordinator. In this way, the coordinator gets realtime feedback on the relative settings and performance of the sources and can observe trends within a particular source at one location. The PC-Link is used for observing relative timing information and for post shot historical archiving. The concept of the PC-Link was originally proposed several years ago. In April 1988, in-house implementation of the link software was begun. The PC-Link receives approximately 2 Kbytes of data per source per shot. This data is converted from MODCOMP format to IBM PC format and archived to disk. The last 280 shots per source are stored to disk to observe trends. The data can be displayed in a number of formats depending upon the situation. For example, prior to a shot, the beam MODCOMPs are sent timing information from the DIII-D tokamak control system. This data is echoed on the PC in a graphical representation displaying all 8 sources. At the end of the shot, the actual running times are displayed along with the requested settings. Any subset of the Historical data may be displayed either graphically or in tables for realtime comparisons between sources. 4 figs

Interactive nuclear plant analyzer for VVER-440 reactor

International Nuclear Information System (INIS)

Shier, W.; Horak, W.; Kennett, R.

1992-05-01

This document discusses an interactive nuclear plant analyzer (NPA) which has been developed for a VVER-440, Model 213 reactor for use in the training of plant personnel, the development and verification of plant operating procedures, and in the analysis of various anticipated operational occurrences and accident scenarios. This NPA is operational on an IBM RISC-6000 workstation and utilizes the RELAP5/MOD2 computer code for the calculation of the VVER-440 reactor response to the interactive commands initiated by the NPA operator

Using Networks For Changing Innovation Strategy: The Case of IBM

OpenAIRE

Dittrich, Koen; Duysters, Geert; Man, Ard-Pieter

2004-01-01

textabstractLarge-scale strategic change projects in companies may be supported by using alliance networks. This paper shows that IBM’s change from an exploitation strategy towards an exploration strategy required a radically different network strategy as well. By entering into more non-equity alliances, involving new partners in the network and loosening the ties with existing partners, IBM supported its transformation from a hardware manufacturing company to a global service provider and so...

Bill Lang's contributions to acoustics at International Business Machines Corporation (IBM), signal processing, international standards, and professionalism in noise control engineering

Science.gov (United States)

Maling, George C.

2005-09-01

Bill Lang joined IBM in the late 1950s with a mandate from Thomas Watson Jr. himself to establish an acoustics program at IBM. Bill created the facilities in Poughkeepsie, developed the local program, and was the leader in having other IBM locations with development and manufacturing responsibilities construct facilities and hire staff under the Interdivisional Liaison Program. He also directed IBMs acoustics technology program. In the mid-1960s, he led an IEEE standards group in Audio and Electroacoustics, and, with the help of James Cooley, Peter Welch, and others, introduced the fast Fourier transform to the acoustics community. He was the convenor of ISO TC 43 SC1 WG6 that began writing the 3740 series of standards in the 1970s. It was his suggestion to promote professionalism in noise control engineering, and, through meetings with Leo Beranek and others, led the founding of INCE/USA in 1971. He was also a leader of the team that founded International INCE in 1974, and he served as president from 1988 until 1999.

Linear array implementation of the EM algorithm for PET image reconstruction

International Nuclear Information System (INIS)

Rajan, K.; Patnaik, L.M.; Ramakrishna, J.

1995-01-01

The PET image reconstruction based on the EM algorithm has several attractive advantages over the conventional convolution back projection algorithms. However, the PET image reconstruction based on the EM algorithm is computationally burdensome for today's single processor systems. In addition, a large memory is required for the storage of the image, projection data, and the probability matrix. Since the computations are easily divided into tasks executable in parallel, multiprocessor configurations are the ideal choice for fast execution of the EM algorithms. In tis study, the authors attempt to overcome these two problems by parallelizing the EM algorithm on a multiprocessor systems. The parallel EM algorithm on a linear array topology using the commercially available fast floating point digital signal processor (DSP) chips as the processing elements (PE's) has been implemented. The performance of the EM algorithm on a 386/387 machine, IBM 6000 RISC workstation, and on the linear array system is discussed and compared. The results show that the computational speed performance of a linear array using 8 DSP chips as PE's executing the EM image reconstruction algorithm is about 15.5 times better than that of the IBM 6000 RISC workstation. The novelty of the scheme is its simplicity. The linear array topology is expandable with a larger number of PE's. The architecture is not dependant on the DSP chip chosen, and the substitution of the latest DSP chip is straightforward and could yield better speed performance

Research center Juelich to install Germany's most powerful supercomputer new IBM System for science and research will achieve 5.8 trillion computations per second

CERN Multimedia

2002-01-01

"The Research Center Juelich, Germany, and IBM today announced that they have signed a contract for the delivery and installation of a new IBM supercomputer at the Central Institute for Applied Mathematics" (1/2 page).

CC-3 CAMAC crate controller for IBM PC

International Nuclear Information System (INIS)

Khare, A.N.; Ghodgaonkar, M.D.; Bairi, B.R.

1991-01-01

The specifications and implementation details of CAMAC Crate Controller CC-3 for IBM-PC compatible as a host computer, having capability to transfer high speed data with direct memory access (DMA) scheme and logic to execute CAMAC cycles directly from the crate controller, to implement the block algorithms specified in ANSI/IEEE Std. 683-1976 (Reaff-1981) are described. The maximum data transfer rate measured with 8 bit interface of PC-AT is 240K byte per second. This work is carried out under Seventh Five Year Plan Project on Modernisation of reactor Control Instrumentation and Development of CAMAC and Fastbus Instrumentation. (author). 9 refs., 5 figs., 4 appendixes

open-quotes Shift-Betelclose quotes: A (very) distributed mainframe

International Nuclear Information System (INIS)

Segal, B.; Martin, O.; Hassine, F.; Hemmer, F.; Jouanigot, J.M.

1994-01-01

Over the last four years, CERN has progressively converted its central batch production facilities from classic mainframe platforms (Cray XMP, IBM, ESA, Vax 9000) to distributed RISC based facilities, which have now attained a very large size. Both a CPU-intensive system (open-quotes CSFclose quotes, the Central Simulation Facility) and an I/O-intensive system (open-quotes SHIFTclose quotes, the Scaleable Heterogeneous Integrated Facility) have been developed, plus a distributed data management subsystem allowing seamless access to CERN'S central tape store and to large amounts of economical disk space. The full system is known as open-quotes COREclose quotes, the Centrally Operated Risc Environment; at the time of writing CORE comprises around 2000 CERN Units of Computing (about 8000 MIPs) and over a TeraByte of online disk space. This distributed system is connected using standard networking technologies (IP protocols over Ethernet, FDDI and UltraNet), but which until quite recently were only implemented at sufficiently high speed in the Local Area

Using a Cray Y-MP as an array processor for a RISC Workstation

Science.gov (United States)

Lamaster, Hugh; Rogallo, Sarah J.

1992-01-01

As microprocessors increase in power, the economics of centralized computing has changed dramatically. At the beginning of the 1980's, mainframes and super computers were often considered to be cost-effective machines for scalar computing. Today, microprocessor-based RISC (reduced-instruction-set computer) systems have displaced many uses of mainframes and supercomputers. Supercomputers are still cost competitive when processing jobs that require both large memory size and high memory bandwidth. One such application is array processing. Certain numerical operations are appropriate to use in a Remote Procedure Call (RPC)-based environment. Matrix multiplication is an example of an operation that can have a sufficient number of arithmetic operations to amortize the cost of an RPC call. An experiment which demonstrates that matrix multiplication can be executed remotely on a large system to speed the execution over that experienced on a workstation is described.

Measurement system microdensitometer Joyce-Loebl and computer IBM-PC for quantitative evaluation of autoradiograms

International Nuclear Information System (INIS)

Chajecki, T.

1992-01-01

The description of measurement system microdensitometer Joyce-Loebl, computer IBM-PC interface are given in the report. This system gives the possibility to save and processing of autoradiograms quantity data. (author). 2 refs, 14 figs, 2 tabs

The Upper- to Middle-Crustal Section of the Alisitos Oceanic Arc, (Baja, Mexico): an Analog of the Izu-Bonin-Marianas (IBM) Arc

Science.gov (United States)

Medynski, S.; Busby, C.; DeBari, S. M.; Morris, R.; Andrews, G. D.; Brown, S. R.; Schmitt, A. K.

2016-12-01

The Rosario segment of the Cretaceous Alisitos arc in Baja California is an outstanding field analog for the Izu-Bonin-Mariana (IBM) arc, because it is structurally intact, unmetamorphosed, and has superior three-dimensional exposures of an upper- to middle-crustal section through an extensional oceanic arc. Previous work1, done in the pre-digital era, used geologic mapping to define two phases of arc evolution, with normal faulting in both phases: (1) extensional oceanic arc, with silicic calderas, and (2) oceanic arc rifting, with widespread diking and dominantly mafic effusions. Our new geochemical data match the extensional zone immediately behind the Izu arc front, and is different from the arc front and rear arc, consistent with geologic relations. Our study is developing a 3D oceanic arc crustal model, with geologic maps draped on Google Earth images, and GPS-located outcrop information linked to new geochemical, geochronological and petrographic data, with the goal of detailing the relationships between plutonic, hypabyssal, and volcanic rocks. This model will be used by scientists as a reference model for past (IBM-1, 2, 3) and proposed IBM (IBM-4) drilling activities. New single-crystal zircon analysis by TIMS supports the interpretation, based on batch SIMS analysis of chemically-abraded zircon1, that the entire upper-middle crustal section accumulated in about 1.5 Myr. Like the IBM, volcanic zircons are very sparse, but zircon chemistry on the plutonic rocks shows trace element compositions that overlap to those measured in IBM volcanic zircons by A. Schmitt (unpublished data). Zircons have U-Pb ages up to 20 Myr older than the eruptive age, suggesting remelting of older parts of the arc, similar to that proposed for IBM (using different evidence). Like IBM, some very old zircons are also present, indicating the presence of old crustal fragments, or sediments derived from them, in the basement. However, our geochemical data show that the magmas are

A low-cost general purpose spectral display unit using an IBM PC

International Nuclear Information System (INIS)

Robinson, S.L.

1986-01-01

Many physics experiments require acquisition and analysis of spectral data. Commercial minicomputer-based multichannel analyzers collect detected counts at various energies, create a histogram of the counts in memory, and display the resultant spectra. They acquire data and provide the user-to-display interface. The system discussed separates functions into the three modular components of data acquisition, storage, and display. This decoupling of functions allows the experimenter to use any number of detectors for data collection before forwarding up to 64 spectra to the display unit, thereby increasing data throughput over that available with commercial systems. An IBM PC was chosen for the low-cost, general purpose display unit. Up to four spectra may be displayed simultaneously in different colors. The histogram saves 1024 channels per detector, 640 of which may be distinctly displayed per spectra. The IEEE-488 standard provides the data path between the IBM PC and the data collection unit. Data is sent to the PC under interrupt control, using direct memory access. Display manipulations available via keyboard are also discussed

MICROPROCESADOR DIDÁCTICO DE ARQUITECTURA RISC IMPLEMENTADO EN UN FPGA

Directory of Open Access Journals (Sweden)

Víctor H. García Ortega

2009-01-01

Full Text Available En este trabajo se presenta el diseño e implementación de un microprocesador de 16 bits de arquitectura RISC tipo MIPS. Las características principales que presenta el microprocesador son: una arquitectura Harvard con una memoria de programa de 64K x 25 bits y una memoria de datos de 64k x 16 bits, una pila de ocho niveles implementada en hardware y la Unidad Lógica-Aritmética (ALU con esquema de acarreo anticipado por propagación y generación para el aumento de velocidad en la ejecución de las operaciones aritméticas. La unidad de control decodifica y maneja las señales de control del microprocesador para ejecutar las instrucciones en un solo ciclo de reloj. La implementación se realizó en un dispositivo lógico programable del tipo FPGA (Field Programmable Gate Array de la familia Spartan-3A de Xilinx. El diseño de cada elemento del microprocesador se desarrolló con el lenguaje de descripción de hardware VHDL.

Multi-bits error detection and fast recovery in RISC cores

International Nuclear Information System (INIS)

Wang Jing; Yang Xing; Zhang Weigong; Shen Jiao; Qiu Keni; Zhao Yuanfu

2015-01-01

The particles-induced soft errors are a major threat to the reliability of microprocessors. Even worse, multi-bits upsets (MBUs) are ever-increased due to the rapidly shrinking feature size of the IC on a chip. Several architecture-level mechanisms have been proposed to protect microprocessors from soft errors, such as dual and triple modular redundancies (DMR and TMR). However, most of them are inefficient to combat the growing multi-bits errors or cannot well balance the critical paths delay, area and power penalty. This paper proposes a novel architecture, self-recovery dual-pipeline (SRDP), to effectively provide soft error detection and recovery with low cost for general RISC structures. We focus on the following three aspects. First, an advanced DMR pipeline is devised to detect soft error, especially MBU. Second, SEU/MBU errors can be located by enhancing self-checking logic into pipelines stage registers. Third, a recovery scheme is proposed with a recovery cost of 1 or 5 clock cycles. Our evaluation of a prototype implementation exhibits that the SRDP can successfully detect particle-induced soft errors up to 100% and recovery is nearly 95%, the other 5% will inter a specific trap. (paper)

Multi-bits error detection and fast recovery in RISC cores

Science.gov (United States)

Jing, Wang; Xing, Yang; Yuanfu, Zhao; Weigong, Zhang; Jiao, Shen; Keni, Qiu

2015-11-01

The particles-induced soft errors are a major threat to the reliability of microprocessors. Even worse, multi-bits upsets (MBUs) are ever-increased due to the rapidly shrinking feature size of the IC on a chip. Several architecture-level mechanisms have been proposed to protect microprocessors from soft errors, such as dual and triple modular redundancies (DMR and TMR). However, most of them are inefficient to combat the growing multi-bits errors or cannot well balance the critical paths delay, area and power penalty. This paper proposes a novel architecture, self-recovery dual-pipeline (SRDP), to effectively provide soft error detection and recovery with low cost for general RISC structures. We focus on the following three aspects. First, an advanced DMR pipeline is devised to detect soft error, especially MBU. Second, SEU/MBU errors can be located by enhancing self-checking logic into pipelines stage registers. Third, a recovery scheme is proposed with a recovery cost of 1 or 5 clock cycles. Our evaluation of a prototype implementation exhibits that the SRDP can successfully detect particle-induced soft errors up to 100% and recovery is nearly 95%, the other 5% will inter a specific trap.

The IBM PC as an Online Search Machine--Part 2: Physiology for Searchers.

Science.gov (United States)

Kolner, Stuart J.

1985-01-01

Enumerates "hardware problems" associated with use of the IBM personal computer as an online search machine: purchase of machinery, unpacking of parts, and assembly into a properly functioning computer. Components that allow transformations of computer into a search machine (combination boards, printer, modem) and diagnostics software…

System of image package input and output for neutron radiography based on PC IBM XT/AT; Sistema paketnogo vvoda i vyvoda izobrazhenij dlya nejtronnoj radiografii na baze PEhVM IBM PC XCT/AT

Energy Technology Data Exchange (ETDEWEB)

Avarzad, O; Rikhvitskij, V S

1996-12-31

System of acquisition and analysis of both statistic and dynamic images of neutron radiography includes NM IBM PC XT/AT, super vidicon, telecamera based video detector, color monitor and interface board of image input-output. 2 refs.

IbM PENYUSUNAN PENILAIAN AUTENTIK BAGI GURU SEKOLAH DI PONPES DARUL FIKRI BAWEN

Directory of Open Access Journals (Sweden)

Joko Siswanto

2015-09-01

Full Text Available Abstract Low motivation of teachers in implementing authentic assessment becomes the basis for IbM team to carry out extension activities. Authentic assessment has actually been around a long time, but this issue arose when the curriculum was launched in 2013. During this time, most of the teachers at school in the field only make an assessment test course, not many people touched assessment tests that are written. Through activities of IbM Authentic Assessment Preparation Training for Teachers of Pesantren Darul Fikri Bawen, participants are expected to conduct a written assessment, performance assessment, product assessment projects, portfolio assessment, and manage the mark using computer-based process. Prior to socialization, teachers must first take pretest and post test. Pre test shows an average score of 89.65 while the average of post-test scores shows 97.6. During the activities, the participants felt helped and gave a positive response to organized similar activities. Keywords: Preparation, Assessment Authentic, Darul Fikri Boarding School Teacher

Vad och hur gör de? − att synliggöra lärande i grundskolans slöjdpraktik via videoetnografi och mikroanalys

Directory of Open Access Journals (Sweden)

Marléne Johansson

2011-11-01

Full Text Available Artikeln bygger på resultat och erfarenheter av etnografiskt insamlade videoinspelningar från grundskolans slöjdundervisning utgående från tre studier; dels vid ett projekt med förstudier under slutet av 1990-talet (Johansson, 1996, dels vid avhandlingsprojektet Slöjdpraktik i skolan (Johansson, 2002 och dels inom forskningsprojektet Kommunikation och lärande i slöjdpraktiker, (”Komolär-projektet”, under 2005−2010 (Lindström, Borg, Johansson & Lindberg, 2003.Att insamla empiri i autentiska slöjdmiljöer är av intresse då lärandesituationer kan synliggöras när elever med hjälp av material och redskap arbetar med att tillverka artefakter. Utifrån detaljerade analyser av slöjdaktiviteter går det att upptäcka det som utspelar sig och möjligheter ges att uppfatta något annat jämfört med vad man kan tro känna väl eller ha förenklade och till och med felaktiga uppfattningar om. Videoobservationer möjliggör att antaganden istället görs på empiriskt grundat datamaterial. Med risk att videofilma och analysera det man tror sig veta och söka har forskningsprojektens insamlingar mer förutsättningslöst arbetat efter vad och hur elever och lärare gör i slöjdpraktik och vad man får veta när slöjdaktiviteter analyseras mer ingående. Videomaterialen har analyserats både på en mer övergripande nivå och detaljerat med hjälp av mikroanalyser. Därefter har lärandet synliggjorts och beskrivits bland annat i teman för att visa hur personerna är resurser för varandra och hur lärandet utvecklas genom olika språkanvändning och med slöjdpraktikens fysiska redskap och material.Sökord: metod, slöjd, klassrumsforskning, videoetnografi, mikroanalysURN:NBN:no-29955

Pengembangan Sistem Informasi Geografis Berbasis Node.JS untuk Pemetaan Mesin dan Tracking Engineer dengan Pemanfaatan Geolocation pada PT IBM Indonesia

OpenAIRE

Fajrin, Rachmat

2017-01-01

PT IBM memiliki banyak klien di Indonesia, ini membuat persebaran produk (dalam hal ini mesin atm) yang semakin meluas di wilayah Indonesia. Hal ini memicu PT IBM untuk menempatkan engineer dibanyak wilayah untuk memenuhi kebutuhan services dan maintenance. Untuk itu dalam penelitian ini dikembangkan sebuah sistem informasi geografis untuk pemetaan mesin dan tracking engineer dengan pemanfaatan geolocation yang bertujuan untuk menampilkan peta digital beserta lokasi mesin dan engineer di selu...

Hazardous Waste Cleanup: IBM Corporation-TJ Watson Research Center in Yorktown Heights, New York

Science.gov (United States)

IBM Corporation -TJ Watson Research Center is located in southern Yorktown near the boundary separating the Town of Yorktown from the Town of New Castle. The site occupies an area of approximately 217 acres and adjoins land uses are predominantly residenti

IBM ThinkPad radiation testing and recovery during EUROMIR missions

International Nuclear Information System (INIS)

Martignano, M.; Harboe-Sorensen, R.

1995-01-01

This paper presents the results of an experiment, conducted on-board the Russian MIR Space Station during a joint Russian and European mission, EUROMIR '94. A commercially available IBM ThinkPad 750C was evaluated by running a software system which monitored the notebook's behavior and counted the number of single event upsets. The used software system and ground verification tests are also presented. Finally, another software system, able to ruggedize normal personal computers for usage in space, is described

Description of the Rigid Triaxial Deformation at Low Energy in 76Ge with the Proton-Neutron Interacting Model IBM2

International Nuclear Information System (INIS)

Zhang Da-Li; Ding Bin-Gang

2013-01-01

We investigate properties of the low-lying energy states for 76 Ge within the framework of the proton-neutron interacting model IBM2, considering the validity of the Z = 38 subshell closure 88 Sr 50 as a doubly magic core. By introducing the quadrupole interactions among like bosons to the IBM2 Hamiltonian, the energy levels for both the ground state and γ bands are reproduced well. Particularly, the doublet structure of the γ band and the energy staggering signature fit the experimental data correctly. The ratios of B(E2) transition strengths for some states of the γ band, and the g factors of the 2 1 + , 2 2 + states are very close to the experimental data. The calculation result indicates that the nucleus exhibiting rigid triaxial deformation in the low-lying states can be described rather well by the IBM2

PC-Link historical data base system MODCOMP/IBM at link for neutral particle beam operation

International Nuclear Information System (INIS)

Thurgood, P.

1989-12-01

''PC-Link'' is a combination of hardware and software that connects an IBM PC/AT to a MODCOMP minicomputer. It is designed as an aid to the Neutral Beam operations coordinator during injection into the DIII-D tokamak project. An IBM PC/AT is linked to 4 MODCOMP ''realtime'' acquisition systems, each of which controls 2 neutral particle beam sources. At various points in the shot sequence, data is sent to the IBM PC/AT. This data can then be integrated with the data from the other sources into tables or graphics displays for use by the Beam Coordinator. In this way, the coordinator gets realtime feedback on the relative settings and performance of the sources and can observe trends within a particular source at one location. The PC- Link is used for observing relative timing information and for post shot historical archiving. The concept of the PC-Link was originally proposed several years ago. In April 1988, in-house implementation of the link software was begun. The PC-Link receives approximately 2 Kbytes of data per source per shot. This data is converted from MODCOMP format to IBM PC format and archived to disk. The last 280 shots per source are stored to disk to observe trends. The data can be displayed in a number of formats depending upon the situation. For example, prior to a shot, the beam MODCOMPs are sent timing information from the DIII-D tokamak control system. This data is echoed on the PC in a graphical representation displaying all 8 sources. At the end of the shot, the actual running times are displayed along with the requested settings. Any subset of the Historical data may be displayed either graphically or in tables for realtime comparisons between sources. This system is designed for realtime use, not for complete archiving purposes. This same data is also sent to a VAX computer for full integration into the archive database. This system is easily upgradable and extremely versatile. 4 figs

The IBM PC as an Online Search Machine. Part 5: Searching through Crosstalk.

Science.gov (United States)

Kolner, Stuart J.

1985-01-01

This last of a five-part series on using the IBM personal computer for online searching highlights a brief review, search process, making the connection, switching between screens and modes, online transaction, capture buffer controls, coping with options, function keys, script files, processing downloaded information, note to TELEX users, and…

User instructions for levelized power generation cost codes using an IBM-type PC

International Nuclear Information System (INIS)

Coen, J.J.; Delene, J.G.

1989-01-01

Programs for the calculation of levelized power generation costs using an IBM or compatible PC are described. Cost calculations for nuclear plants and coal-fired plants include capital investment cost, operation and maintenance cost, fuel cycle cost, decommissioning cost, and total levelized power generation cost. 7 refs., 36 figs., 4 tabs

Comunicação Interna na Era da Colaboração: A IBM Brasil

Directory of Open Access Journals (Sweden)

Ademir Balbino Siqueira Filho

2015-11-01

Full Text Available A transformação em seu modelo de negócio, deixando de ser somente fábrica de computadores os desafios do mundo globalizado e o surgimento de novos valores socioculturais determinaram novos rumos à comunicação interna da International Business Machine (IBM Brasil, empresa subsidiária de uma das maiores empresas de Tecnologia da Informação do mundo – a IBM. Diante de novas estratégias de comunicação interna, meios tradicionais de comunicação dividem o espaço ou, então, dão espaço a novos meios, no qual os colaboradores interagem entre si e com a empresa de uma maneira mais direta, mais rápida e menos formal. 

Demonstration of entanglement assisted invariance on IBM's quantum experience.

Science.gov (United States)

Deffner, Sebastian

2017-11-01

Quantum entanglement is among the most fundamental, yet from classical intuition also most surprising properties of the fully quantum nature of physical reality. We report several experiments performed on IBM's Quantum Experience demonstrating envariance - entanglement assisted invariance. Envariance is a recently discovered symmetry of composite quantum systems, which is at the foundational origin of physics and a quantum phenomenon of pure states. These very easily reproducible and freely accessible experiments on Quantum Experience provide simple tools to study the properties of envariance, and we illustrate this for several cases with "quantum universes" consisting of up to five qubits.

2-D fluid dynamics models for laser driven fusion on IBM 3090 vector multiprocessors

International Nuclear Information System (INIS)

Atzeni, S.

1988-01-01

Fluid-dynamics codes for laser fusion are complex research codes, consisting of many distinct modules and embodying a variety of numerical methods. They are therefore good candidates for testing general purpose advanced computer architectures and the related software. In this paper, after a brief outline of the basic concepts of laser fusion, the implementation of the 2-D laser fusion fluid code DUED on the IBM 3090 VF vector multiprocessors is discussed. Emphasis is put on parallelization, performed by means of IBM Parallel FORTRAN (PF). It is shown how different modules have been optimized by using different features of PF: i) modules based on depth-2 nested loops exploit automatic parallelization; ii) laser light ray tracing is partitioned by scheduling parallel ICCG algorithm (executed in parallel by appropiately synchronized parallel subroutines). Performance results are given for separate modules of the code, as well as for typical complete runs

The new ENSDF search system NESSY: IBM/PC nuclear spectroscopy database

International Nuclear Information System (INIS)

Boboshin, I.N.; Varlamov, V.V.

1996-01-01

The universal relational nuclear structure and decay database NESSY (New ENSDF Search SYstem) developed for the IBM/PC and compatible PCs, and based on the international file ENSDF (Evaluated Nuclear Structure Data File), is described. The NESSY provides the possibility of high efficiency processing (the search and retrieval of any kind of physical data) of the information from ENSDF. The principles of the database development are described and examples of applications are presented. (orig.)

An IBM-1620 code for calculation of isotopic composition of irradiated thorium (ISOCOM-2)

International Nuclear Information System (INIS)

Soliman, R.H.; Karchava, G.; Hamouda, I.

1978-01-01

The present work gives a description of an IBM-1620 code to calculate the isotopic composition during the irradiation of a nuclear fuel, which initially contains 232 Th. The numerical results on test calculations are presented. The code has been in operation since 1968

76 FR 21033 - International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales...

Science.gov (United States)

2011-04-14

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,364] International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales Solution Department, Off-Site Teleworker in Centerport, New York; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated November 29, 2011,...

Approximate Quantum Adders with Genetic Algorithms: An IBM Quantum Experience

Directory of Open Access Journals (Sweden)

Li Rui

2017-07-01

Full Text Available It has been proven that quantum adders are forbidden by the laws of quantum mechanics. We analyze theoretical proposals for the implementation of approximate quantum adders and optimize them by means of genetic algorithms, improving previous protocols in terms of efficiency and fidelity. Furthermore, we experimentally realize a suitable approximate quantum adder with the cloud quantum computing facilities provided by IBM Quantum Experience. The development of approximate quantum adders enhances the toolbox of quantum information protocols, paving the way for novel applications in quantum technologies.

Handbook of univariate and multivariate data analysis with IBM SPSS

CERN Document Server

Ho, Robert

2013-01-01

Using the same accessible, hands-on approach as its best-selling predecessor, the Handbook of Univariate and Multivariate Data Analysis with IBM SPSS, Second Edition explains how to apply statistical tests to experimental findings, identify the assumptions underlying the tests, and interpret the findings. This second edition now covers more topics and has been updated with the SPSS statistical package for Windows.New to the Second EditionThree new chapters on multiple discriminant analysis, logistic regression, and canonical correlationNew section on how to deal with missing dataCoverage of te

Karlstads universitet - Ut i skogen, vad ska jag dit och göra? : En rapport om skapandet av ett unikt monterkoncept

OpenAIRE

Bergman, Karin; Jernberg, Jonna

2012-01-01

Sammanfattning Mässor förekom som fenomen redan under medeltiden och har allt sedan dess använts som en kanal för försäljning och marknadsföring. Idag tävlar företag och organisationer om mässbesökares uppmärksamhet genom att skapa attraktiva montrar med vinnande koncept som ska locka människor och få dem att lägga företagsnamnet på minnet. Detta är vad Karlstads universitet haft i åtanke då de utformat beskrivningen till detta projekt. Bakgrunden till projektet är att universitetet finns r...

SKI2 mediates degradation of RISC 5'-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis.

Science.gov (United States)

Branscheid, Anja; Marchais, Antonin; Schott, Gregory; Lange, Heike; Gagliardi, Dominique; Andersen, Stig Uggerhøj; Voinnet, Olivier; Brodersen, Peter

2015-12-15

Small regulatory RNAs are fundamental in eukaryotic and prokaryotic gene regulation. In plants, an important element of post-transcriptional control is effected by 20-24 nt microRNAs (miRNAs) and short interfering RNAs (siRNAs) bound to the ARGONAUTE1 (AGO1) protein in an RNA induced silencing complex (RISC). AGO1 may cleave target mRNAs with small RNA complementarity, but the fate of the resulting cleavage fragments remains incompletely understood. Here, we show that SKI2, SKI3 and SKI8, subunits of a cytoplasmic cofactor of the RNA exosome, are required for degradation of RISC 5', but not 3'-cleavage fragments in Arabidopsis. In the absence of SKI2 activity, many miRNA targets produce siRNAs via the RNA-dependent RNA polymerase 6 (RDR6) pathway. These siRNAs are low-abundant, and map close to the cleavage site. In most cases, siRNAs were produced 5' to the cleavage site, but several examples of 3'-spreading were also identified. These observations suggest that siRNAs do not simply derive from RDR6 action on stable 5'-cleavage fragments and hence that SKI2 has a direct role in limiting secondary siRNA production in addition to its function in mediating degradation of 5'-cleavage fragments. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Shape coexistence in the neutron-deficient Pt isotopes in the configuration-mixed IBM

International Nuclear Information System (INIS)

Vargas, Carlos E.; Campuzano, Cuauhtemoc; Morales, Irving O.; Frank, Alejandro; Van Isacker, Piet

2008-01-01

The matrix-coherent state approach in the IBM with configuration mixing is used to describe the geometry of neutron-deficient Pt isotopes. Employing a parameter set for all isotopes determined previously, it is found that the lowest minimum goes from spherical to oblate and finally acquires a prolate shape when approaching the mid-shell Pt isotopes

IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC

Directory of Open Access Journals (Sweden)

Hanane Ennajdaoui

2016-05-01

Full Text Available Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3 expression correlates with malignancy, but its role(s in pathogenesis remains enigmatic. We interrogated the IGF2BP3-RNA interaction network in pancreatic ductal adenocarcinoma (PDAC cells. Using a combination of genome-wide approaches, we have identified 164 direct mRNA targets of IGF2BP3. These transcripts encode proteins enriched for functions such as cell migration, proliferation, and adhesion. Loss of IGF2BP3 reduced PDAC cell invasiveness and remodeled focal adhesion junctions. Individual nucleotide resolution crosslinking immunoprecipitation (iCLIP revealed significant overlap of IGF2BP3 and microRNA (miRNA binding sites. IGF2BP3 promotes association of the RNA-induced silencing complex (RISC with specific transcripts. Our results show that IGF2BP3 influences a malignancy-associated RNA regulon by modulating miRNA-mRNA interactions.

IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC.

Science.gov (United States)

Ennajdaoui, Hanane; Howard, Jonathan M; Sterne-Weiler, Timothy; Jahanbani, Fereshteh; Coyne, Doyle J; Uren, Philip J; Dargyte, Marija; Katzman, Sol; Draper, Jolene M; Wallace, Andrew; Cazarez, Oscar; Burns, Suzanne C; Qiao, Mei; Hinck, Lindsay; Smith, Andrew D; Toloue, Masoud M; Blencowe, Benjamin J; Penalva, Luiz O F; Sanford, Jeremy R

2016-05-31

Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression correlates with malignancy, but its role(s) in pathogenesis remains enigmatic. We interrogated the IGF2BP3-RNA interaction network in pancreatic ductal adenocarcinoma (PDAC) cells. Using a combination of genome-wide approaches, we have identified 164 direct mRNA targets of IGF2BP3. These transcripts encode proteins enriched for functions such as cell migration, proliferation, and adhesion. Loss of IGF2BP3 reduced PDAC cell invasiveness and remodeled focal adhesion junctions. Individual nucleotide resolution crosslinking immunoprecipitation (iCLIP) revealed significant overlap of IGF2BP3 and microRNA (miRNA) binding sites. IGF2BP3 promotes association of the RNA-induced silencing complex (RISC) with specific transcripts. Our results show that IGF2BP3 influences a malignancy-associated RNA regulon by modulating miRNA-mRNA interactions. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

The study of structure in 224–234 thorium nuclei within the framework IBM

Directory of Open Access Journals (Sweden)

Lee Su Youn

2017-01-01

Full Text Available An investigation has been made of the behaviour of nuclear structure as a function of an increase in neutron number from 224Th to 234Th. Thorium of mass number 234 is a typical rotor nucleus that can be explained by the SU(3 limit of the interacting boson model(IBM in the algebraic nuclear model. Furthermore, 224−232Th lie on the path of the symmetry-breaking phase transition. Moreover, the nuclear structure of 224Th can be explained using X(5 symmetry. However, as 226−230Th nuclei are not fully symmetrical nuclei, they can be represented by adding a perturbed term to express symmetry breaking. Through the following three calculation steps, we identified the tendency of change in nuclear structure. Firstly, the structure of 232Th is described using the matrix elements of the Hamiltonian and the electric quadrupole operator between basis states of the SU(3 limit in IBM. Secondly, the low-lying energy levels and E2 transition ratios corresponding to the observable physical values are calculated by adding a perturbed term with the first-order Casimir operator of the U(5 limit to the SU(3 Hamiltonian in IBM. We compared the results with experimental data of 224−234Th. Lastly, the potential of the Bohr Hamiltonian is represented by a harmonic oscillator, as a result of which the structure of 224−234Th could be expressed in closed form by an approximate separation of variables. The results of these theoretical predictions clarify nuclear structure changes in Thorium nuclei over mass numbers of practical significance.

Cost-benefit study of consumer product take-back programs using IBM's WIT reverse logistics optimization tool

Science.gov (United States)

Veerakamolmal, Pitipong; Lee, Yung-Joon; Fasano, J. P.; Hale, Rhea; Jacques, Mary

2002-02-01

In recent years, there has been increased focus by regulators, manufacturers, and consumers on the issue of product end of life management for electronics. This paper presents an overview of a conceptual study designed to examine the costs and benefits of several different Product Take Back (PTB) scenarios for used electronics equipment. The study utilized a reverse logistics supply chain model to examine the effects of several different factors in PTB programs. The model was done using the IBM supply chain optimization tool known as WIT (Watson Implosion Technology). Using the WIT tool, we were able to determine a theoretical optimal cost scenario for PTB programs. The study was designed to assist IBM internally in determining theoretical optimal Product Take Back program models and determining potential incentives for increasing participation rates.

Noliktavu vadības sistēmas (WMS) ieviešana un ieviešanas rezultātu analīze loģistikas uzņēmumā AS ,,Dominante Loģistikas Sistēma

OpenAIRE

Morozovs, Gļebs

2010-01-01

Darbā „Noliktavu vadības sistēmas (WMS) ieviešana un ieviešanas rezultātu analīze loģistikas uzņēmumā AS „Dominante Loģistikas Sistēma„ tiek pētīta noliktavu vadības sistēmas ievešanas ietekme uz loģistikas uzņēmumu. Darbā izpētīts loģistikas saturs un funkcionālās sfēra, aplūkoti noliktavu un transporta loģistika pamatprincipi un mijiedarbība, analizētas loģistikas attīstības tendences un loma Latvijas tautsaimniecība. Izpētīti noliktavu un transporta loģistikas instrumenti, raksturota infor...

IBM-PC based data acquisition system for a laser enhanced ionisation spectrometer using a low cost GPIB card

International Nuclear Information System (INIS)

Sampath Kumar, R.; Ravindranath, S.V.G.

1992-01-01

An IBM-PC based data acquisition system has been developed for the existing laser enhanced ionisation spectrometer in the Division. Here the boxcar averager (type SR 250) which integrates the spectrometer output is interfaced to an IBM-PC, converted into a GPIB controller with the help of a locally available GPIB card, (Dynalog Micro Systems make PCL 848) through the GPIB port of the computer interface module (SR 245). The menu driven software developed in BASIC, triggers the scan in the dye laser through its control port, collects data from the spectrometer, plots, displays and stores it on the hard disc for further use. (author). 6 refs., 18 figs., 2 appendixes

Performance characteristics of the Mayo/IBM PACS

Science.gov (United States)

Persons, Kenneth R.; Gehring, Dale G.; Pavicic, Mark J.; Ding, Yingjai

1991-07-01

The Mayo Clinic and IBM (at Rochester, Minnesota) have jointly developed a picture archiving system for use with Mayo's MRI and Neuro CT imaging modalities. The communications backbone of the PACS is a portion of the Mayo institutional network: a series of 4-Mbps token rings interconnected by bridges and fiber optic extensions. The performance characteristics of this system are important to understand because they affect the response time a PACS user can expect, and the response time for non-PACS users competing for resources on the institutional network. The performance characteristics of each component and the average load levels of the network were measured for various load distributions. These data were used to quantify the response characteristics of the existing system and to tune a model developed by North Dakota State University Department of Computer Science for predicting response times of more complex topologies.

Letter from Hong Kong: A Report on Chinese Food, Fake Apples, and IBM's Asian Strategy.

Science.gov (United States)

Immel, A. Richard

1984-01-01

Notes that microcomputer use in Hong Kong's small business community does not reflect the growth of its high-tech electronics industry and discusses IBM's influence in Hong Kong and Asia, the counterfeiting of Apple microcomputers and software, and why Apple currently has no recourse. (MBR)

76 FR 54800 - International Business Machines (IBM), Software Group Business Unit, Quality Assurance Group, San...

Science.gov (United States)

2011-09-02

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,554] International Business Machines (IBM), Software Group Business Unit, Quality Assurance Group, San Jose, California; Notice of Negative Determination on Reconsideration On January 21, 2011, the Department of Labor (Department) issued an Affirmative Determination Regarding...

Driving the Power of AIX Performance Tuning on IBM Power

CERN Document Server

Milberg, Ken

2009-01-01

A concise reference for IT professionals, this book goes beyond the rules and contains the best practices and strategies for solid tuning methodology. Tips based on years of experience from an AIX tuning master show specific steps for monitoring and tuning CPU, virtual memory, disk I/O, and network components. Also offering techniques for tuning Oracle and Linux structures that run on an IBM power system-as well as for the new AIX 6.1-this manual discusses what tools are available, how to best use them to collect historical data, and when to analyze trends and results. The only comprehensive,

SKI2 mediates degradation of RISC 5′-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis

Science.gov (United States)

Branscheid, Anja; Marchais, Antonin; Schott, Gregory; Lange, Heike; Gagliardi, Dominique; Andersen, Stig Uggerhøj; Voinnet, Olivier; Brodersen, Peter

2015-01-01

Small regulatory RNAs are fundamental in eukaryotic and prokaryotic gene regulation. In plants, an important element of post-transcriptional control is effected by 20–24 nt microRNAs (miRNAs) and short interfering RNAs (siRNAs) bound to the ARGONAUTE1 (AGO1) protein in an RNA induced silencing complex (RISC). AGO1 may cleave target mRNAs with small RNA complementarity, but the fate of the resulting cleavage fragments remains incompletely understood. Here, we show that SKI2, SKI3 and SKI8, subunits of a cytoplasmic cofactor of the RNA exosome, are required for degradation of RISC 5′, but not 3′-cleavage fragments in Arabidopsis. In the absence of SKI2 activity, many miRNA targets produce siRNAs via the RNA-dependent RNA polymerase 6 (RDR6) pathway. These siRNAs are low-abundant, and map close to the cleavage site. In most cases, siRNAs were produced 5′ to the cleavage site, but several examples of 3′-spreading were also identified. These observations suggest that siRNAs do not simply derive from RDR6 action on stable 5′-cleavage fragments and hence that SKI2 has a direct role in limiting secondary siRNA production in addition to its function in mediating degradation of 5′-cleavage fragments. PMID:26464441

Materials accounting system for an IBM PC

International Nuclear Information System (INIS)

Bearse, R.C.; Thomas, R.J.; Henslee, S.P.; Jackson, B.G.; Tracy, D.B.; Pace, D.M.

1986-01-01

We have adapted the Los Alamos MASS accounting system for use on an IBM PC/AT at the Fuels Manufacturing Facility (FMF) at Argonne National Laboratory-West (ANL-WEST) in Idaho Falls, Idaho. Cost of hardware and proprietary software was less than $10,000 per station. The system consists of three stations between which accounting information is transferred using floppy disks accompanying special nuclear material shipments. The programs were implemented in dBASEIII and were compiled using the proprietary software CLIPPER. Modifications to the inventory can be posted in just a few minutes, and operator/computer interaction is nearly instantaneous. After the records are built by the user, it takes 4 to 5 seconds to post the results to the database files. A version of this system was specially adapted and is currently in use at the FMF facility at Argonne National Laboratory in Idaho Falls. Initial satisfaction is adequate and software and hardware problems are minimal

MOLECULAR DESIGNER: an interactive program for the display of protein structure on the IBM-PC.

Science.gov (United States)

Hannon, G J; Jentoft, J E

1985-09-01

A BASIC interactive graphics program has been developed for the IBM-PC which utilizes the graphics capabilities of that computer to display and manipulate protein structure from coordinates. Structures may be generated from typed files, or from Brookhaven National Laboratories' Protein Data Bank data tapes. Once displayed, images may be rotated, translated and expanded to any desired size. Figures may be viewed as ball-and-stick or space-filling models. Calculated multiple-point perspective may also be added to the display. Docking manipulations are possible since more than a single figure may be displayed and manipulated simultaneously. Further, stereo images and red/blue three-dimensional images may be generated using the accompanying DESIPLOT program and an HP-7475A plotter. A version of the program is also currently available for the Apple Macintosh. Full implementation on the Macintosh requires 512 K and at least one disk drive. Otherwise this version is essentially identical to the IBM-PC version described herein.

An IBM-1620 code for calculaton of isotopic composition of irradiated uranium (ISOCOM-1)

International Nuclear Information System (INIS)

Soliman, R.H.; Karchava, G.; Hamouda, I.

1974-01-01

The present work gives a description of an IBM-1620 code to calculate the isotopic composition during the irradiation of a nuclear fuel, which initially consists of 235 U and 238 U. The numerical results of test calculations as well as the ET-RR-1 reactor calculations are presented. The code is in operation since 1968

Low dose radiation effects: an integrative european approach (Risc-Rad Project) coordinated by the Cea

International Nuclear Information System (INIS)

Sabatier, L.

2006-01-01

RISC-RAD (Radiosensitivity of Individuals and Susceptibility to Cancer induced by ionizing Radiations) is an Integrated Project funded by the European Commission under 6. Framework Programme / EURATOM. RISC-RAD started on 1. January 2004 for a duration of four years. Coordinated by Cea (Dr Laure Sabatier), it involves 11 European countries (Austria, Denmark, Finland, France, Germany, Ireland, Italy, the Netherlands, Spain, Sweden and the United Kingdom) and 29 research institutions. Objectives: Exposures to low and protracted doses of ionizing radiation are very frequent in normal living environment, at work places, in industry and in medicine. Effects of these exposures on human health cannot be reliably assessed by epidemiological methods, nor is thoroughly understood by biologists. RISC-RAD project proposes to help bridging the gap of scientific knowledge about these effects. To achieve this goal, a necessary key step is to understand the basic mechanisms by which radiation induces cancer. Studying this multistage process in an integrated way, the project offers a new biological approach characterised by and clear-cut and objective-driven scientific policy: the project is focused on the effects of low doses (less than 100 mSv) and protracted doses of radiation. It aims at identifying new parameters that take into account the differences in radiation responses between individuals. A group of modelers works closely with the experimental teams in order to better quantify the risks associated with low and protracted doses. Research work is divided into five work packages interacting closely with each other. WP1 is dedicated to DNA damage. Ionizing Radiation (IR) produce a broad spectrum of base modifications and DNA strand breaks of different kinds, among which double-strand breaks and 'clustered damage' which is thought to be a major feature in biological effectiveness of IR. The aim of Work Package 1 is to improve understanding of the initial DNA damage induced by

Programming portlets from JSR 168 to IBM WebSphere portal extensions

CERN Document Server

Bernal, Joey; Lynn, Ron; Marston, Cayce; Memon, Usman

2012-01-01

Portals have evolved from simple Web applications with multiple links to an enterprise application delivery platform that serves composite applications. In a world where organizations are gearing up with service-oriented architecture (SOA) strategies and re-working existing apps to fit the Web 2.0 programming model, portals are strategic infrastructure components on every CIO's radar. As companies move toward SOA, portlets become an even hotter topic. Portlets provide the user interface for these services. IBM's unwavering commitment to open standards such as Java Specification Request (JSR 16

Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

Science.gov (United States)

Castanotto, Daniela; Sakurai, Kumi; Lingeman, Robert; Li, Haitang; Shively, Louise; Aagaard, Lars; Soifer, Harris; Gatignol, Anne; Riggs, Arthur; Rossi, John J.

2007-01-01

Despite the great potential of RNAi, ectopic expression of shRNA or siRNAs holds the inherent risk of competition for critical RNAi components, thus altering the regulatory functions of some cellular microRNAs. In addition, specific siRNA sequences can potentially hinder incorporation of other siRNAs when used in a combinatorial approach. We show that both synthetic siRNAs and expressed shRNAs compete against each other and with the endogenous microRNAs for transport and for incorporation into the RNA induced silencing complex (RISC). The same siRNA sequences do not display competition when expressed from a microRNA backbone. We also show that TAR RNA binding protein (TRBP) is one of the sensors for selection and incorporation of the guide sequence of interfering RNAs. These findings reveal that combinatorial siRNA approaches can be problematic and have important implications for the methodology of expression and use of therapeutic interfering RNAs. PMID:17660190

Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach.

Science.gov (United States)

Cambronne, Xiaolu A; Shen, Rongkun; Auer, Paul L; Goodman, Richard H

2012-12-11

Identifying targets is critical for understanding the biological effects of microRNA (miRNA) expression. The challenge lies in characterizing the cohort of targets for a specific miRNA, especially when targets are being actively down-regulated in miRNA- RNA-induced silencing complex (RISC)-messengerRNA (mRNA) complexes. We have developed a robust and versatile strategy called RISCtrap to stabilize and purify targets from this transient interaction. Its utility was demonstrated by determining specific high-confidence target datasets for miR-124, miR-132, and miR-181 that contained known and previously unknown transcripts. Two previously unknown miR-132 targets identified with RISCtrap, adaptor protein CT10 regulator of kinase 1 (CRK1) and tight junction-associated protein 1 (TJAP1), were shown to be endogenously regulated by miR-132 in adult mouse forebrain. The datasets, moreover, differed in the number of targets and in the types and frequency of microRNA recognition element (MRE) motifs, thus revealing a previously underappreciated level of specificity in the target sets regulated by individual miRNAs.

Shape coexistence in the neutron-deficient Pt isotopes in a configuration mixing IBM

International Nuclear Information System (INIS)

Morales, Irving O.; Vargas, Carlos E.; Frank, Alejandro

2004-01-01

The recently proposed matrix-coherent state approach for configuration mixing IBM is used to describe the evolving geometry of the neutron deficient Pt isotopes. It is found that the Potential Energy Surface (PES) of the Platinum isotopes evolves, when the number of neutrons decreases, from spherical to oblate and then to prolate shapes, in agreement with experimental measurements. Oblate-Prolate shape coexistence is observed in 194,192Pt isotopes

IBM Demonstrates a General-Purpose, High-Performance, High-Availability Cloud-Hosted Data Distribution System With Live GOES-16 Weather Satellite Data

Science.gov (United States)

Snyder, P. L.; Brown, V. W.

2017-12-01

IBM has created a general purpose, data-agnostic solution that provides high performance, low data latency, high availability, scalability, and persistent access to the captured data, regardless of source or type. This capability is hosted on commercially available cloud environments and uses much faster, more efficient, reliable, and secure data transfer protocols than the more typically used FTP. The design incorporates completely redundant data paths at every level, including at the cloud data center level, in order to provide the highest assurance of data availability to the data consumers. IBM has been successful in building and testing a Proof of Concept instance on our IBM Cloud platform to receive and disseminate actual GOES-16 data as it is being downlinked. This solution leverages the inherent benefits of a cloud infrastructure configured and tuned for continuous, stable, high-speed data dissemination to data consumers worldwide at the downlink rate. It also is designed to ingest data from multiple simultaneous sources and disseminate data to multiple consumers. Nearly linear scalability is achieved by adding servers and storage.The IBM Proof of Concept system has been tested with our partners to achieve in excess of 5 Gigabits/second over public internet infrastructure. In tests with live GOES-16 data, the system routinely achieved 2.5 Gigabits/second pass-through to The Weather Company from the University of Wisconsin-Madison SSEC. Simulated data was also transferred from the Cooperative Institute for Climate and Satellites — North Carolina to The Weather Company, as well. The storage node allocated to our Proof of Concept system as tested was sized at 480 Terabytes of RAID protected disk as a worst case sizing to accommodate the data from four GOES-16 class satellites for 30 days in a circular buffer. This shows that an abundance of performance and capacity headroom exists in the IBM design that can be applied to additional missions.

Homomorphic encryption experiments on IBM's cloud quantum computing platform

Science.gov (United States)

Huang, He-Liang; Zhao, You-Wei; Li, Tan; Li, Feng-Guang; Du, Yu-Tao; Fu, Xiang-Qun; Zhang, Shuo; Wang, Xiang; Bao, Wan-Su

2017-02-01

Quantum computing has undergone rapid development in recent years. Owing to limitations on scalability, personal quantum computers still seem slightly unrealistic in the near future. The first practical quantum computer for ordinary users is likely to be on the cloud. However, the adoption of cloud computing is possible only if security is ensured. Homomorphic encryption is a cryptographic protocol that allows computation to be performed on encrypted data without decrypting them, so it is well suited to cloud computing. Here, we first applied homomorphic encryption on IBM's cloud quantum computer platform. In our experiments, we successfully implemented a quantum algorithm for linear equations while protecting our privacy. This demonstration opens a feasible path to the next stage of development of cloud quantum information technology.

LERC-SLAM - THE NASA LEWIS RESEARCH CENTER SATELLITE LINK ATTENUATION MODEL PROGRAM (IBM PC VERSION)

Science.gov (United States)

Manning, R. M.

1994-01-01

antenna required to establish a link with the satellite, the statistical parameters that characterize the rainrate process at the terminal site, the length of the propagation path within the potential rain region, and its projected length onto the local horizontal. The IBM PC version of LeRC-SLAM (LEW-14979) is written in Microsoft QuickBASIC for an IBM PC compatible computer with a monitor and printer capable of supporting an 80-column format. The IBM PC version is available on a 5.25 inch MS-DOS format diskette. The program requires about 30K RAM. The source code and executable are included. The Macintosh version of LeRC-SLAM (LEW-14977) is written in Microsoft Basic, Binary (b) v2.00 for Macintosh II series computers running MacOS. This version requires 400K RAM and is available on a 3.5 inch 800K Macintosh format diskette, which includes source code only. The Macintosh version was developed in 1987 and the IBM PC version was developed in 1989. IBM PC is a trademark of International Business Machines. MS-DOS is a registered trademark of Microsoft Corporation. Macintosh is a registered trademark of Apple Computer, Inc.

Artificial intelligence in neurodegenerative disease research: use of IBM Watson to identify additional RNA-binding proteins altered in amyotrophic lateral sclerosis.

Science.gov (United States)

Bakkar, Nadine; Kovalik, Tina; Lorenzini, Ileana; Spangler, Scott; Lacoste, Alix; Sponaugle, Kyle; Ferrante, Philip; Argentinis, Elenee; Sattler, Rita; Bowser, Robert

2018-02-01

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in ALS, with mutations in 11 RBPs causing familial forms of the disease, and 6 more RBPs showing abnormal expression/distribution in ALS albeit without any known mutations. RBP dysregulation is widely accepted as a contributing factor in ALS pathobiology. There are at least 1542 RBPs in the human genome; therefore, other unidentified RBPs may also be linked to the pathogenesis of ALS. We used IBM Watson ® to sieve through all RBPs in the genome and identify new RBPs linked to ALS (ALS-RBPs). IBM Watson extracted features from published literature to create semantic similarities and identify new connections between entities of interest. IBM Watson analyzed all published abstracts of previously known ALS-RBPs, and applied that text-based knowledge to all RBPs in the genome, ranking them by semantic similarity to the known set. We then validated the Watson top-ten-ranked RBPs at the protein and RNA levels in tissues from ALS and non-neurological disease controls, as well as in patient-derived induced pluripotent stem cells. 5 RBPs previously unlinked to ALS, hnRNPU, Syncrip, RBMS3, Caprin-1 and NUPL2, showed significant alterations in ALS compared to controls. Overall, we successfully used IBM Watson to help identify additional RBPs altered in ALS, highlighting the use of artificial intelligence tools to accelerate scientific discovery in ALS and possibly other complex neurological disorders.

Multivariate methods and forecasting with IBM SPSS statistics

CERN Document Server

Aljandali, Abdulkader

2017-01-01

This is the second of a two-part guide to quantitative analysis using the IBM SPSS Statistics software package; this volume focuses on multivariate statistical methods and advanced forecasting techniques. More often than not, regression models involve more than one independent variable. For example, forecasting methods are commonly applied to aggregates such as inflation rates, unemployment, exchange rates, etc., that have complex relationships with determining variables. This book introduces multivariate regression models and provides examples to help understand theory underpinning the model. The book presents the fundamentals of multivariate regression and then moves on to examine several related techniques that have application in business-orientated fields such as logistic and multinomial regression. Forecasting tools such as the Box-Jenkins approach to time series modeling are introduced, as well as exponential smoothing and naïve techniques. This part also covers hot topics such as Factor Analysis, Dis...

IBM Watson Analytics: Automating Visualization, Descriptive, and Predictive Statistics.

Science.gov (United States)

Hoyt, Robert Eugene; Snider, Dallas; Thompson, Carla; Mantravadi, Sarita

2016-10-11

We live in an era of explosive data generation that will continue to grow and involve all industries. One of the results of this explosion is the need for newer and more efficient data analytics procedures. Traditionally, data analytics required a substantial background in statistics and computer science. In 2015, International Business Machines Corporation (IBM) released the IBM Watson Analytics (IBMWA) software that delivered advanced statistical procedures based on the Statistical Package for the Social Sciences (SPSS). The latest entry of Watson Analytics into the field of analytical software products provides users with enhanced functions that are not available in many existing programs. For example, Watson Analytics automatically analyzes datasets, examines data quality, and determines the optimal statistical approach. Users can request exploratory, predictive, and visual analytics. Using natural language processing (NLP), users are able to submit additional questions for analyses in a quick response format. This analytical package is available free to academic institutions (faculty and students) that plan to use the tools for noncommercial purposes. To report the features of IBMWA and discuss how this software subjectively and objectively compares to other data mining programs. The salient features of the IBMWA program were examined and compared with other common analytical platforms, using validated health datasets. Using a validated dataset, IBMWA delivered similar predictions compared with several commercial and open source data mining software applications. The visual analytics generated by IBMWA were similar to results from programs such as Microsoft Excel and Tableau Software. In addition, assistance with data preprocessing and data exploration was an inherent component of the IBMWA application. Sensitivity and specificity were not included in the IBMWA predictive analytics results, nor were odds ratios, confidence intervals, or a confusion matrix

76 FR 5832 - International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA...

Science.gov (United States)

2011-02-02

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,554] International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA, San Jose, CA; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated November 29, 2010, a worker and a state workforce official...

Note on some quasielastic neutron scattering analysis programs on the Rutherford Laboratory IBM 360/195

International Nuclear Information System (INIS)

Richardson, R.M.

1979-12-01

A suite of programs for analysing neutron scattering data from time-of-flight spectrometers has been implemented on the Rutherford Laboratory IBM 360/195 computer system. The programs are intended for near inelastic and quasielastic data and operate by convoluting the measured instrumental resolution function with a model scattering function before fitting to the measured sample scattering law. (author)

SFAP: Scan-Tron Forms Analysis Package for the IBM-PC. User's Guide, Version 2.0.

Science.gov (United States)

Harnisch, Delwyn L.; And Others

The Scan-Tron Forms Analysis Package (SFAP) is a collection of integrated programs that allow an IBM-PC (or compatible) to collect data from a Scan-Tron 1200 forms reader. In addition to the basic data acquisition capability, the SFAP has additional capabilities related to the viewing and formatting of incoming data. When used in combination with…

Ibm BAGI GURU DAN SISWA SMU SETIA BUDI SEMARANG

Directory of Open Access Journals (Sweden)

Adhi Kusmantoro

2016-06-01

Full Text Available Dalam dunia industri ada beberapasistem yang digunakan dalam mengoperasikan sistem pengendalielektromagnetik, antara lain sistem pengoperasian secara manual, semi otomatisdan otomatis.Tujuan pengabdian masyarakat di SMU Setia Budi Semarang adalah untuk memberikan kemampuan penggunaan software EKTS dan menambah pengetahuan atau wawasan teknik pengendali listrik di industri yang sedang berkembang dan banyak dipakai. Metode pelaksanaan kegiatan program Iptek bagi Masyarakat (IbM yang digunakan adalah metode pelatihan yang dibagi dalam tiga tahap, yaitu pelatihan secara teori, pelatihan menggunakan softawre EKTS dan beberapa rancangan pengendali motor listrik, dan tahap evaluasi dalam kegiatan awal sampai dengan akhir. Dalam kegiatan pengabdian masyarakat di SMU Setia Budi Semarang telah dibuat pengendali start stop, pengendali motor berurutan, dan pengendali membalik putaran motor listrik. ?é?á Kata Kunci : EKTS, motor listrik, kontaktor magnet

Present status and future of the sophisticated work station

Science.gov (United States)

Ishida, Haruhisa

The excellency of the work station is explained, by comparing the functions of software and hardware of work station with those of personal computer. As one of the examples utilizing the functions of work station, desk top publishing is explained. By describing the competition between the Group of ATT · Sun Microsystems which intends to have the leadership by integrating Berkeley version which is most popular at this moment and System V version, and the group led by IBM, future of UNIX as OS of work station is predicted. Development of RISC processor, TRON Plan and Sigma Projects by MITI are also mentioned as its background.

Mikado: A graphic program

Science.gov (United States)

Secretan, Y.

A discussion of the modular program Mikado is presented. Mikado was developed with the goal of creating a flexible graphic tool to display and help analyze the results of finite element fluid flow computations. Mikado works on unstructured meshes, with elements of mixed geometric type, but also offers the possibility of using structured meshes. The program can be operated by both menu and mouse (interactive), or by command file (batch). Mikado is written in FORTRAN, except for a few system dependent subroutines which are in C. It runs presently on Silicon Graphics' workstations and could be easily ported to the IBM-RISC System/6000 family of workstations.

Fast algorithm for the rendering of three-dimensional surfaces

Science.gov (United States)

Pritt, Mark D.

1994-02-01

It is often desirable to draw a detailed and realistic representation of surface data on a computer graphics display. One such representation is a 3D shaded surface. Conventional techniques for rendering shaded surfaces are slow, however, and require substantial computational power. Furthermore, many techniques suffer from aliasing effects, which appear as jagged lines and edges. This paper describes an algorithm for the fast rendering of shaded surfaces without aliasing effects. It is much faster than conventional ray tracing and polygon-based rendering techniques and is suitable for interactive use. On an IBM RISC System/6000TM workstation it renders a 1000 X 1000 surface in about 7 seconds.

Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.

Science.gov (United States)

Sand, Michael; Skrygan, Marina; Georgas, Dimitrios; Arenz, Christoph; Gambichler, Thilo; Sand, Daniel; Altmeyer, Peter; Bechara, Falk G

2012-11-01

The microprocessor complex mediates intranuclear biogenesis of precursor microRNAs from the primary microRNA transcript. Extranuclear, mature microRNAs are incorporated into the RNA-induced silencing complex (RISC) before interaction with complementary target mRNA leads to transcriptional repression or cleavage. In this study, we investigated the expression profiles of the microprocessor complex subunit DiGeorge syndrome critical region gene 8 (DGCR8) and the RISC components argonaute-1 (AGO1), argonaute-2 (AGO2), as well as double-stranded RNA-binding proteins PACT, TARBP1, and TARBP2 in epithelial skin cancer and its premalignant stage. Patients with premalignant actinic keratoses (AK, n = 6), basal cell carcinomas (BCC, n = 15), and squamous cell carcinomas (SCC, n = 7) were included in the study. Punch biopsies were harvested from the center of the tumors (lesional), from healthy skin sites (intraindividual controls), and from healthy skin sites in a healthy control group (n = 16; interindividual control). The DGCR8, AGO1, AGO2, PACT, TARBP1, and TARBP2 mRNA expression levels were detected by quantitative real-time reverse transcriptase polymerase chain reaction. The DGCR8, AGO1, AGO2, PACT, and TARBP1 expression levels were significantly higher in the AK, BCC, and SCC groups than the healthy controls (P  0.05). This study indicates that major components of the miRNA pathway, such as the microprocessor complex and RISC, are dysregulated in epithelial skin cancer. Copyright © 2011 Wiley Periodicals, Inc.

Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model.

Science.gov (United States)

van Kempen, Bob J H; Ferket, Bart S; Hofman, Albert; Steyerberg, Ewout W; Colkesen, Ersen B; Boekholdt, S Matthijs; Wareham, Nicholas J; Khaw, Kay-Tee; Hunink, M G Myriam

2012-12-06

We developed a Monte Carlo Markov model designed to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD. Internal, predictive, and external validity of the model have not yet been established. The Rotterdam Ischemic Heart Disease and Stroke Computer Simulation (RISC) model was developed using data covering 5 years of follow-up from the Rotterdam Study. To prove 1) internal and 2) predictive validity, the incidences of coronary heart disease (CHD), stroke, CVD death, and non-CVD death simulated by the model over a 13-year period were compared with those recorded for 3,478 participants in the Rotterdam Study with at least 13 years of follow-up. 3) External validity was verified using 10 years of follow-up data from the European Prospective Investigation of Cancer (EPIC)-Norfolk study of 25,492 participants, for whom CVD and non-CVD mortality was compared. At year 5, the observed incidences (with simulated incidences in brackets) of CHD, stroke, and CVD and non-CVD mortality for the 3,478 Rotterdam Study participants were 5.30% (4.68%), 3.60% (3.23%), 4.70% (4.80%), and 7.50% (7.96%), respectively. At year 13, these percentages were 10.60% (10.91%), 9.90% (9.13%), 14.20% (15.12%), and 24.30% (23.42%). After recalibrating the model for the EPIC-Norfolk population, the 10-year observed (simulated) incidences of CVD and non-CVD mortality were 3.70% (4.95%) and 6.50% (6.29%). All observed incidences fell well within the 95% credibility intervals of the simulated incidences. We have confirmed the internal, predictive, and external validity of the RISC model. These findings provide a basis for analyzing the effects of modifying cardiovascular disease risk factors on the burden of CVD with the RISC model.

Validation of a model to investigate the effects of modifying cardiovascular disease (CVD risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC model

Directory of Open Access Journals (Sweden)

van Kempen Bob JH

2012-12-01

Full Text Available Abstract Background We developed a Monte Carlo Markov model designed to investigate the effects of modifying cardiovascular disease (CVD risk factors on the burden of CVD. Internal, predictive, and external validity of the model have not yet been established. Methods The Rotterdam Ischemic Heart Disease and Stroke Computer Simulation (RISC model was developed using data covering 5 years of follow-up from the Rotterdam Study. To prove 1 internal and 2 predictive validity, the incidences of coronary heart disease (CHD, stroke, CVD death, and non-CVD death simulated by the model over a 13-year period were compared with those recorded for 3,478 participants in the Rotterdam Study with at least 13 years of follow-up. 3 External validity was verified using 10 years of follow-up data from the European Prospective Investigation of Cancer (EPIC-Norfolk study of 25,492 participants, for whom CVD and non-CVD mortality was compared. Results At year 5, the observed incidences (with simulated incidences in brackets of CHD, stroke, and CVD and non-CVD mortality for the 3,478 Rotterdam Study participants were 5.30% (4.68%, 3.60% (3.23%, 4.70% (4.80%, and 7.50% (7.96%, respectively. At year 13, these percentages were 10.60% (10.91%, 9.90% (9.13%, 14.20% (15.12%, and 24.30% (23.42%. After recalibrating the model for the EPIC-Norfolk population, the 10-year observed (simulated incidences of CVD and non-CVD mortality were 3.70% (4.95% and 6.50% (6.29%. All observed incidences fell well within the 95% credibility intervals of the simulated incidences. Conclusions We have confirmed the internal, predictive, and external validity of the RISC model. These findings provide a basis for analyzing the effects of modifying cardiovascular disease risk factors on the burden of CVD with the RISC model.

An Amphibious Ship-To-Shore Simulation for Use on an IBM PC (Personal Computer)

Science.gov (United States)

1984-09-01

CA : «< <- j Special ■ *- amphibious ship- an IBM Personal ion of the phy- he logic used analysis, and a DD | JAM 11 1473 COITION...research, for instance, wiL1 be geared toward a technically oriented person who is familiar with computers, programming and the associated logic. A...problem, often vaguely stated by the decision aaker , into precise and operational terms [Ref. Hz p.51]. The analysis begins with specification of the

A FORTRAN program for an IBM PC compatible computer for calculating kinematical electron diffraction patterns

International Nuclear Information System (INIS)

Skjerpe, P.

1989-01-01

This report describes a computer program which is useful in transmission electron microscopy. The program is written in FORTRAN and calculates kinematical electron diffraction patterns in any zone axis from a given crystal structure. Quite large unit cells, containing up to 2250 atoms, can be handled by the program. The program runs on both the Helcules graphic card and the standard IBM CGA card

Theoretical studies in nuclear physics. Three year progress report and final report

International Nuclear Information System (INIS)

Landau, R.H.; Madsen, V.A.

1996-01-01

In 1995 the DOE grant in Nuclear theory with Professors Rubin H. Landau and Victor A. Madsen as co-principal investigators ended. Their research was carried out in collaboration with graduate students in Corvallis, and with scientists at LLNL-Livermore, Los Alamos, TRIUMF, KFA-Julich, Hamburg University, Melbourne University, The Thinking Machine Corporation and IBM Research. Activities in nuclear and particle physics at Oregon State University (OSU) were diverse and active. Madsen's work concentrated on the relation of reactions to the nuclear structure, and Landau's work concentrated on intermediate energy physics, few-body problems, and computational physics. The Landau group had a weekly meeting of students and visitors. There was a weekly nuclear seminar with experimental and theoretical colleagues, and a weekly departmental colloquium. The DOE support had permitted the group to run Unix workstations networked to other computers in the Physics Department and the University. Since 1990 OSU has been using IBM RISC System 6000/model 530 with console and four X-stations. The equipment was purchased and is maintained with yearly DOE funding of the group

NAMMU (Release 6.1) for the IBM RS/6000: installation and running

International Nuclear Information System (INIS)

Cliffe, K.A.

1993-12-01

NAMMU is a software package for modelling groundwater flow and transport in porous media. The package can be used to model steady-state and time-dependent behaviour, including unsaturated flow and the transport of heat and mass. An option is available for modelling radioactive decay and transport of chains of radionuclides. The software is based on an efficient implementation of the finite-element method that provides many options for modelling complex geological strata. This report describes how to install and run Release 6.1 of NAMMU on an IBM RS/6000 using version 6.1.4 of the job submission script. (Author)

Operational experience with open communication in the field of building automation at the IBM center Ehningen; GA-Betriebserfahrung - mit offener Kommunikation im Informatikzentrum Ehningen

Energy Technology Data Exchange (ETDEWEB)

Damnig, A [IBM Deutschland Informationssysteme GmbH, Ehningen bei Boeblingen (Germany)

1995-12-31

In chapter 21 of the anthology about building control the operational experience with open communication in the field of building automation is discussed. The following aspects are discussed: building automation at IBM in Ehningen, the FACN experience, what has been achieved? Energy and operation optimisation. (BWI) [Deutsch] Kapitel 21 des Sammelbandes ueber Building Control ist dem Thema der Betriebserfahrung mit Gebaeudeautomationen mit offener Kommunikation gewidmet. In diesem Zusammenhang werden folgende Themenbereiche angesprochen: Gebaeudeautomation bei IBM in Ehningen, das FACN-Protokoll; Betriebserfahrungen; Was wurde erreicht?; Energie- und Betriebsoptimierungen. (BWI)

Unloading at Cointrin Airport of the IBM 709 computer

CERN Multimedia

CERN PhotoLab

1960-01-01

CERN's first computer, a huge vacuum-tube Ferranti Mercury, was installed in building 2 in 1958. With its 60 microsecond clock cycle, it was a million times slower than today's big computers. The Mercury took 3 months to install and filled a huge room, even so, its computational ability didn't quite match that of a modern pocket calculator. "Mass" storage was provided by four magnetic drums each holding 32K x 20 bits - not enough to hold the data from a single proton-proton collision in the LHC. It was replaced in 1960 by the IBM 709 computer, seen here being unloaded at Cointrin airport. Although it was taken over so quickly by transistor equipped machines, a small part of the Ferranti Mercury remains. The computer's engineers installed a warning bell to signal computing errors - it can still be found mounted on the wall in a corridor of building 2.

The I.B.M. 7090 programmes PERSEUS, ARIADNE, CERBERUS

International Nuclear Information System (INIS)

Green, C.

1964-08-01

An account is given of the programmes PERSEUS, ARIADNE and CERBERUS, written in the Fortran II language for the I.B.M. 7090 computer. PERSEUS calculates multigroup fluxes in a multiregion lattice cell possessing cylindrical symmetry, and which is assumed infinite in the axial direction. Neutron transport is represented by means of first collision probabilities and, at the cell boundary, a 'white' boundary condition is imposed. ARIADNE is a modified version of PERSEUS and calculates multigroup average axial and radial diffusion coefficients in the lattice cell. CERBERUS is also based on PERSEUS and calculates fluxes in an infinite lattice composed of two types of cell arranged in a 'checkerboard' fashion. The two types of cell are assumed infinite axially, cylindrically symmetric and possessing the same maximum radial dimension, but may otherwise be differently constituted. All three programmes have input requirements similar to those of the Winfrith DSN programme. (author)

Authoritarian Decision-Making and Alternative Patterns of Power and Influence: The Mexican IBM Case

Science.gov (United States)

1988-05-01

de Control de Cambios," pp. 1341-1345 and " Decreto Sobre Control de Camblos," pp. 1346-1354. Acceleration of the rate of devaluation was announced in...see " Decreto para la raclonalizaclon de [a industrla automotrlz," Diarlo OfIclal, 15 September 1983 as cited by Bennett and Sharpe, Transnational...v ’ i i I . . . . . . . ". . . . 170 the rules of foreign Investment in the area of computation where IBM wanted to expand Its operations. Programa

OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery.

OpenAIRE

Sean Ekins; Alexander L Perryman; Carolina Horta Andrade

2016-01-01

The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock tens of millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of...

Determination of Hamiltonian matrix for IBM4 and compare it is self value with shells model

International Nuclear Information System (INIS)

Slyman, S.; Hadad, S.; Souman, H.

2004-01-01

The Hamiltonian is determined using the procedure OAI and the mapping of (IBM4) states into the shell model, which is based on the seniority classification scheme. A boson sub-matrix of the shell model Hamiltonian for the (sd) 4 configuration is constructed, and is proved to produce the same eigenvalues as the shell model Hamiltonian for the corresponding fermion states. (authors)

Clinical aspects of the Mayo/IBM PACS project

Science.gov (United States)

Forbes, Glenn S.; Morin, Richard L.; Pavlicek, William

1991-07-01

A joint project between Mayo Clinic and IBM to develop a picture archival and communications system has been under development for three years. This project began as a potential solution to a pressing archival problem in magnetic resonance imaging. The project has grown to encompass a much larger sphere of activity including workstations, image retrieval, and report archival. This report focuses on the clinical aspects involved in the design, development, and implementation of such a system. In particular, emphasis is placed on the clinical impact of the system both inside and outside of the radiology department. The primary concerns have centered on fidelity of archival data, ease of use, and diagnostic efficacy. The project to date has been limited to neuroradiology practice. This group consists of nine staff radiologists and fellows. Administrative policy decisions regarding the accessibility and available of digital data in the clinical environment have been much more difficult and complex than originally conceived. Based on the observations thus far, the authors believe the system will become a useful and valuable adjunct to clinical practice of radiology.

IbM PENGEMBANGAN POTENSI LOKAL POSDAYA DURIAN JAYA MENUJU DESA WISATA DI KELURAHAN BUBAKAN, KEC. MIJEN, KOTA SEMARANG

Directory of Open Access Journals (Sweden)

Rasiman .

2015-09-01

Full Text Available Abstract ?é?á Based on the data analysis of monograph in Bubakan Village, whichhas various kinds of?é?á potential local resources (e.q:fruits, plants vegetable and cattle, Posdaya Durian Jayaas a partner of IbM, has some potential activities that can be developed?é?á as pioneer of potential local tourist resort intheareaofBubakanvillage. The present activities of the Posdaya are divided into several fields:a.Education;b.Health;c.Entrepreneurship; andd.Environment Care. Those localpotentialresources were still needed serious managerial development in accordance todesign a new local tourist resort. The IbM activities in RW02 Bubakan aimed at 1 making cat fish abon and various food from flourmocaf, 2 conducting a seminar with village officials, community leaders, and the group Posdaya to design a?é?á tourist village. 3 socializing about?é?á nutrients forchildren in Posyandu ?óÔé¼?ôMawar Dua?óÔé¼?Ø. Keyword: local potential resources, Posdaya Durian Jaya, local tourist resort

STAPRE and SCAT2. Statistical pre-equilibrium and optical nuclear model code for Personal Computer IBM/AT

International Nuclear Information System (INIS)

Goulo, V.G.

1988-01-01

This document describes the content of the diskettes with nuclear data production codes SCAT2 and STAPRE and the example data set for implementing and testing of these codes for personal computers IBM/AT. They are available on two diskettes, free fo charge, upon request from the NEA Data Bank, Saclay, France. (author). 4 refs, 1 fig

IBM-PC based high voltage controller [Paper No.: L7

International Nuclear Information System (INIS)

Mondal, N.K.; Kalmani, S.D.

1993-01-01

A simple IBM-PC/XT based high voltage controller is designed for C.A.E.N. high voltage supply unit, which is being used for testing the prototype detector for future accelerator experiment. The high voltage output of the supply unit can be remotely programmed. The V-set Lemo connectors at the rear panel provides the remote control facility. Similarly V-mon and I-mon can be used for remotely monitoring the voltage set and the current drawn from the supply unit. The controller described here sets the high voltage through V-set and monitors the voltage set, through V-mon at a pre-determined time interval. The monitoring is a background job and is done as an interrupt service routine of IRQ3. A simple menu driven software package used is written in Q-Basic and MASM. (author). 1 fig

Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic β-cells.

Science.gov (United States)

Milochau, Alexandra; Lagrée, Valérie; Benassy, Marie-Noëlle; Chaignepain, Stéphane; Papin, Julien; Garcia-Arcos, Itsaso; Lajoix, Anne; Monterrat, Carole; Coudert, Laetitia; Schmitter, Jean-Marie; Ochoa, Begoña; Lang, Jochen

2014-06-27

Synaptotagmins are two C2 domain-containing transmembrane proteins. The function of calcium-sensitive members in the regulation of post-Golgi traffic has been well established whereas little is known about the calcium-insensitive isoforms constituting half of the protein family. Novel binding partners of synaptotagmin 11 were identified in β-cells. A number of them had been assigned previously to ER/Golgi derived-vesicles or linked to RNA synthesis, translation and processing. Whereas the C2A domain interacted with the Q-SNARE Vti1a, the C2B domain of syt11 interacted with the SND1, Ago2 and FMRP, components of the RNA-induced silencing complex (RISC). Binding to SND was direct via its N-terminal tandem repeats. Our data indicate that syt11 may provide a link between gene regulation by microRNAs and membrane traffic. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

A full automatic system controlled with IBM-PC/XT micro-computer for neutron activation analysis

International Nuclear Information System (INIS)

Song Quanxun

1992-01-01

A full automatic system controlled with micro-computers for NAA is described. All processes are automatically completed with an IBM-PC/XT micro-computer. The device is stable, reliable, flexible and convenient for use and has many functions and applications in automatical analysis of long, middle and short lived nuclides. Due to a high working efficiency of the instrument and micro-computers, both time and power can be saved. This method can be applied in other nuclear analysis techniques

Performance of the IBM synchrotron X-ray source for lithography

International Nuclear Information System (INIS)

Archie, C.

1993-01-01

The compact superconducting synchrotron X-ray source at the IBM Advanced Lithography Facility in East Fishkill, New York has been in service to customers since the start of 1992. It availability during scheduled time is greater than 90%, with recent months frequently surpassing 95%. Data on the long-term behavior of the X-ray source properties and subsystem performance are now available. The full system continues to meet all specifications and even to surpass them in key areas. Measured electron beam properties such as beam size, short- and long-term positional stability, and beam life are presented. Lifetimes greater than 20 hours for typical stored beams have significantly simplified operations and increased availability compared to projections. This paper also describes some unique features of this X-ray source and goes beyond a discussion of downtime to describe the efforts behind the scenes to maintain and operate it

The finite element structural analysis code SAP IV conversion from CDC to IBM

International Nuclear Information System (INIS)

Harrop, L.P.

1977-02-01

SAP IV is a general three dimensional, linear, static and dynamic finite element structural analysis program. The program which was obtained from the Earthquake Engineering Research Center, University of California, Berkeley, was written in FORTRAM for a CDC 6400. Its main use was anticipated to be the seismic analysis of reactor structures. SAP IV may also prove useful for fracture mechanics studies as well as the usual elastic stress analysis of structures. A brief description of SAP IV and a more detailed account of the FORTRAN conversion required to make SAP IV run successfully on the UKAEA Harwell IBM 370/168 are given. (author)

STARS: An Integrated, Multidisciplinary, Finite-Element, Structural, Fluids, Aeroelastic, and Aeroservoelastic Analysis Computer Program

Science.gov (United States)

Gupta, K. K.

1997-01-01

A multidisciplinary, finite element-based, highly graphics-oriented, linear and nonlinear analysis capability that includes such disciplines as structures, heat transfer, linear aerodynamics, computational fluid dynamics, and controls engineering has been achieved by integrating several new modules in the original STARS (STructural Analysis RoutineS) computer program. Each individual analysis module is general-purpose in nature and is effectively integrated to yield aeroelastic and aeroservoelastic solutions of complex engineering problems. Examples of advanced NASA Dryden Flight Research Center projects analyzed by the code in recent years include the X-29A, F-18 High Alpha Research Vehicle/Thrust Vectoring Control System, B-52/Pegasus Generic Hypersonics, National AeroSpace Plane (NASP), SR-71/Hypersonic Launch Vehicle, and High Speed Civil Transport (HSCT) projects. Extensive graphics capabilities exist for convenient model development and postprocessing of analysis results. The program is written in modular form in standard FORTRAN language to run on a variety of computers, such as the IBM RISC/6000, SGI, DEC, Cray, and personal computer; associated graphics codes use OpenGL and IBM/graPHIGS language for color depiction. This program is available from COSMIC, the NASA agency for distribution of computer programs.

UWGSP6: a diagnostic radiology workstation of the future

Science.gov (United States)

Milton, Stuart W.; Han, Sang; Choi, Hyung-Sik; Kim, Yongmin

1993-06-01

The Univ. of Washington's Image Computing Systems Lab. (ICSL) has been involved in research into the development of a series of PACS workstations since the middle 1980's. The most recent research, a joint UW-IBM project, attempted to create a diagnostic radiology workstation using an IBM RISC System 6000 (RS6000) computer workstation and the X-Window system. While the results are encouraging, there are inherent limitations in the workstation hardware which prevent it from providing an acceptable level of functionality for diagnostic radiology. Realizing the RS6000 workstation's limitations, a parallel effort was initiated to design a workstation, UWGSP6 (Univ. of Washington Graphics System Processor #6), that provides the required functionality. This paper documents the design of UWGSP6, which not only addresses the requirements for a diagnostic radiology workstation in terms of display resolution, response time, etc., but also includes the processing performance necessary to support key functions needed in the implementation of algorithms for computer-aided diagnosis. The paper includes a description of the workstation architecture, and specifically its image processing subsystem. Verification of the design through hardware simulation is then discussed, and finally, performance of selected algorithms based on detailed simulation is provided.

Impacts of the IBM Cell Processor to Support Climate Models

Science.gov (United States)

Zhou, Shujia; Duffy, Daniel; Clune, Tom; Suarez, Max; Williams, Samuel; Halem, Milt

2008-01-01

NASA is interested in the performance and cost benefits for adapting its applications to the IBM Cell processor. However, its 256KB local memory per SPE and the new communication mechanism, make it very challenging to port an application. We selected the solar radiation component of the NASA GEOS-5 climate model, which: (1) is representative of column physics (approximately 50% computational time), (2) has a high computational load relative to transferring data from and to main memory, (3) performs independent calculations across multiple columns. We converted the baseline code (single-precision, Fortran) to C and ported it with manually SIMDizing 4 independent columns and found that a Cell with 8 SPEs can process 2274 columns per second. Compared with the baseline results, the Cell is approximately 5.2X, approximately 8.2X, approximately 15.1X faster than a core on Intel Woodcrest, Dempsey, and Itanium2, respectively. We believe this dramatic performance improvement makes a hybrid cluster with Cell and traditional nodes competitive.

Enhancing organization and maintenance of big data with Apache Solr in IBM WebSphere Commerce deployments

OpenAIRE

Grigel, Rudolf

2015-01-01

The main objective of this thesis was to enhance the organization and maintenance of big data with Apache Solr in IBM WebSphere Commerce deployments. This objective can be split into several subtasks: reorganization of data, fast and optimised exporting and importing, efficient update and cleanup operations. E-Commerce is a fast growing and frequently changing environment. There is a constant flow of data that is rapidly growing larger and larger every day which is becoming an ...

A CAMAC crate controller KK009 for the Pravetz-16 and IBM PC/XT personal computers

International Nuclear Information System (INIS)

Georgiev, A.; Churin, I.N.

1988-01-01

A CAMAC crate controller and a computer bus adapter for the Pravetz 16 and IBM PC/XT personal computers are described. The following features are included in the controller: operation under program control; access to CAMAC registers treated as memory locations corresponding to given N, A, F; hardware for fast LAM processing and execution of multi-crate commands; device up to 7 crates in one CAMAC system; built-in hardware for controller and crate dataway test

A microscopic derivation of the dependence of the IBM3 hamiltonian on the boson number and isospin

International Nuclear Information System (INIS)

Evans, J.A.; Long, G.L.P.; Elliott, J.P.

1993-01-01

The number and isospin dependence of the hamiltonian in the isospin invariant form (IBM3) of the boson model has been deduced from a seniority mapping into a single j-shell, making use of shell-model formulae recently obtained from vector coherent state theory. Numerical results are given for a specific shell-model example and the qualitative behaviour of the different parameters in the hamiltonian is discussed. (orig.)

A Conceptual Framework for the Electronic Performance Support Systems within IBM Lotus Notes 6 (LN6 Example

Directory of Open Access Journals (Sweden)

Servet BAYRAM

2005-10-01

Full Text Available A Conceptual Framework for the Electronic PerformanceSupport Systems within IBM Lotus Notes 6 (LN6 Example Assoc. Prof. Dr. Servet BAYRAM Computer Education & Instructional Technologies Marmara University, TURKEYsbayram@marmara.edu.tr ABSTRACT The concept of Electronic Performance Support Systems (EPSS is containing multimedia or computer based instruction components that improves human performance by providing process simplification, performance information and decision support system. EPSS has become a hot topic for organizational development, human resources, performance technology, training, and educational development professionals. A conceptual framework of EPSS is constructed under five interrelated and interdependent domains for educational implications. The domains of the framework are online collaboration, cost-effectiveness, motivation, service management, and performance empowering. IBM Lotus Notes 6 (LN6 is used as an example application tool to illustrate the power of this framework. The framework describes a set of relevant events based upon deductive analyses for improving our understanding of the EPSS and its implications on education and training. The article is also pointed out that there are some similarities between the EPSS’ and the LN6’s specific features within this conceptual framework. It can provide some guidelines and benefits to researchers, educators, and designers as well.

Effect of system workload on operating system reliability - A study on IBM 3081

Science.gov (United States)

Iyer, R. K.; Rossetti, D. J.

1985-01-01

This paper presents an analysis of operating system failures on an IBM 3081 running VM/SP. Three broad categories of software failures are found: error handling, program control or logic, and hardware related; it is found that more than 25 percent of software failures occur in the hardware/software interface. Measurements show that results on software reliability cannot be considered representative unless the system workload is taken into account. The overall CPU execution rate, although measured to be close to 100 percent most of the time, is not found to correlate strongly with the occurrence of failures. Possible reasons for the observed workload failure dependency, based on detailed investigations of the failure data, are discussed.

Adaptation of the IBM ECR [electric cantilever robot] robot to plutonium processing applications

International Nuclear Information System (INIS)

Armantrout, G.A.; Pedrotti, L.R.; Halter, E.A.; Crossfield, M.

1990-12-01

The changing regulatory climate in the US is adding increasing incentive to reduce operator dose and TRU waste for DOE plutonium processing operations. To help achieve that goal the authors have begun adapting a small commercial overhead gantry robot, the IBM electric cantilever robot (ECR), to plutonium processing applications. Steps are being taken to harden this robot to withstand the dry, often abrasive, environment within a plutonium glove box and to protect the electronic components against alpha radiation. A mock-up processing system for the reduction of the oxide to a metal was prepared and successfully demonstrated. Design of a working prototype is now underway using the results of this mock-up study. 7 figs., 4 tabs

High-speed parallel implementation of a modified PBR algorithm on DSP-based EH topology

Science.gov (United States)

Rajan, K.; Patnaik, L. M.; Ramakrishna, J.

1997-08-01

Algebraic Reconstruction Technique (ART) is an age-old method used for solving the problem of three-dimensional (3-D) reconstruction from projections in electron microscopy and radiology. In medical applications, direct 3-D reconstruction is at the forefront of investigation. The simultaneous iterative reconstruction technique (SIRT) is an ART-type algorithm with the potential of generating in a few iterations tomographic images of a quality comparable to that of convolution backprojection (CBP) methods. Pixel-based reconstruction (PBR) is similar to SIRT reconstruction, and it has been shown that PBR algorithms give better quality pictures compared to those produced by SIRT algorithms. In this work, we propose a few modifications to the PBR algorithms. The modified algorithms are shown to give better quality pictures compared to PBR algorithms. The PBR algorithm and the modified PBR algorithms are highly compute intensive, Not many attempts have been made to reconstruct objects in the true 3-D sense because of the high computational overhead. In this study, we have developed parallel two-dimensional (2-D) and 3-D reconstruction algorithms based on modified PBR. We attempt to solve the two problems encountered by the PBR and modified PBR algorithms, i.e., the long computational time and the large memory requirements, by parallelizing the algorithm on a multiprocessor system. We investigate the possible task and data partitioning schemes by exploiting the potential parallelism in the PBR algorithm subject to minimizing the memory requirement. We have implemented an extended hypercube (EH) architecture for the high-speed execution of the 3-D reconstruction algorithm using the commercially available fast floating point digital signal processor (DSP) chips as the processing elements (PEs) and dual-port random access memories (DPR) as channels between the PEs. We discuss and compare the performances of the PBR algorithm on an IBM 6000 RISC workstation, on a Silicon

Implementation of GENSEC section from HYDRA 3.40 system on IBM 370/135 (DOS/VS 34.0)

International Nuclear Information System (INIS)

Ponta, T.

1984-07-01

In High Energy Physics, processing and interpretation of experimental data, supplied by track-particle detectors, are made by means of HYDRA system. We present here the implementation on IBM 370/135 (DOS/VS 34.0) (belonqing to Central Institute of Physics) of General Section (GENSEC) from HYDRA system, paying a special attention to the description of the 176 routines of this section, in order to facilitate their use on the computer. (author)

Analýza výkonnosti procesorů IBM POWER8

OpenAIRE

Jelen, Jakub

2016-01-01

Práce se zabývá systémem IBM Power8 v porovnání s dnes běžně používanými řešeními s procesory Intel Xeon. Výkonnost je vyhodnocována nejen na úrovni celého systému, ale také na úrovni jednotlivých vláken a jader a paměti. Různé metriky jsou demonstrovány na typických optimalizovaných algoritmech. Testovaný stroj Power8 disponuje extrémně rychlou pamětí poskytující rychlost až 145 GB/s mezi pamětí a procesorem, které se dnešní procesory Intel nevyrovnají. Výpočetní síla je pouze srovnatelná (N...

PREVAIL: IBM's e-beam technology for next generation lithography

Science.gov (United States)

Pfeiffer, Hans C.

2000-07-01

PREVAIL - Projection Reduction Exposure with Variable Axis Immersion Lenses represents the high throughput e-beam projection approach to NGL which IBM is pursuing in cooperation with Nikon Corporation as alliance partner. This paper discusses the challenges and accomplishments of the PREVAIL project. The supreme challenge facing all e-beam lithography approaches has been and still is throughput. Since the throughput of e-beam projection systems is severely limited by the available optical field size, the key to success is the ability to overcome this limitation. The PREVAIL technique overcomes field-limiting off-axis aberrations through the use of variable axis lenses, which electronically shift the optical axis simultaneously with the deflected beam so that the beam effectively remains on axis. The resist images obtained with the Proof-of-Concept (POC) system demonstrate that PREVAIL effectively eliminates off- axis aberrations affecting both resolution and placement accuracy of pixels. As part of the POC system a high emittance gun has been developed to provide uniform illumination of the patterned subfield and to fill the large numerical aperture projection optics designed to significantly reduce beam blur caused by Coulomb interaction.

Guide to data preparation for EQ3/6 (Wolery) modified for the IBM 3033

International Nuclear Information System (INIS)

Noy, D.J.

1981-11-01

The ability to predict mineral-fluid equilibria is an important aspect of geochemical research into radioactive waste disposal. The interaction of ground waters and waste leachates with the host rock of a disposal site, either at elevated or ambient temperatures, will influence the performance of the disposal system. The EQ3/6 package (Wolery, 1979) provides a technique for the prediction of such interactions using available thermodynamic data, and for extrapolating laboratory experimental data on rock-fluid equilibria. This report describes the modifications performed on this package to allow operation on an IBM machine, and is intended as a guide to data preparation for the programmes. (author)

IN10 data processing on the Rutherford Laboratory IBM 360

International Nuclear Information System (INIS)

Howells, W.S.; Anderson, I.S.

1978-09-01

This report described modifications made to some of the IN10 spectrometer data analysis programs in use at the Institut Laue-Langevin, Grenoble in order that they may be used on the IBM 360 system at the Rutherford Laboratory. Fuller descriptions of the programs are contained in the original manual (Users' Guide to Processing IN10 Data by W S Howells, ILL Internal Report (1977). Programs discussed are: a) FAST. A program for fitting Lorentzians to raw data. This is a modification of the ILL programs FAST and HAST. b) SUPER. A convolution program for fitting quasielastic peaks to corrected data. This program is based on the ILL program SUPER. c) SAND. A convolution program for fitting an elastic and a Quasielastic peak to data. This is similar to the ILL version of SAND. d) SWIFT. A program similar to SUPER but faster. It is based on the ILL program CONTTY. Before using these programs users must consult the NBRU in order to obtain an account number and a user identifier. (U.K.)

Implementing Open Innovation: The Case of Natura, IBM and Siemens

Directory of Open Access Journals (Sweden)

Cely Ades

2013-05-01

Full Text Available This paper analyses three case firms whose innovation management processes have been consolidated. The companies Natura, IBM (Brazilian Subsidiary and Siemens (ChemTech/Brazil were studied with the purpose of analysing the implementation of OI, particularly in terms of: (a its alignment with existing corporate strategy; (b its requirements such as culture, skill and motivation; (c the strategy and the implementation process; (d the results achieved (e the present barriers and enablers. The research is qualitative in nature and employs a descriptive approach. The main results of this study, obtained using a method called ‘Collective Subject Speech’ , show that the implementation of OI, both structured and non-structured, is mainly challenged by cultural issues. It has been observed that the implementation of OI process is at its embryonic stage in all case firms and that this occurs along with investments in closed innovation, meaning that OI results cannot be explored at this stage of the implementation, as there is a long way to consolidate these practices in the case firms studied.

Implementation of a parallel algorithm for spherical SN calculations on the IBM 3090

International Nuclear Information System (INIS)

Haghighat, A.; Lawrence, R.D.

1989-01-01

Parallel S N algorithms based on domain decomposition in angle are straightforward to develop in Cartesian geometry because the computation of the angular fluxes for a specific discrete ordinate can be performed independently of all other angles. This is not the case for curvilinear geometries, where the angular redistribution component of the discretized streaming operator results in coupling between angular fluxes along adjacent discrete ordinates. Previously, the authors developed a parallel algorithm for S N calculations in spherical geometry and examined its iterative convergence for criticality and detector problems with differing scattering/absorption ratios. In this paper, the authors describe the implementation of the algorithm on an IBM 3090 Model 400 (four processors) and present computational results illustrating the efficiency of the algorithm relative to serial execution

IBM mainframe security beyond the basics : a practical guide from a z/OS and RACF perspective

CERN Document Server

Dattani, Dinesh D

2013-01-01

Rather than rehashing basic information-such as command syntax-already available in other publications, this book focuses on important security and audit issues, business best practices, and compliance, discussing the important issues in IBM mainframe security. Mainframes are the backbone of most large IT organizations; security cannot be left to chance. With very little training available to the younger crowd, and older, more experienced personnel retiring or close to retiring, there is a need in mainframe security skills at the senior level. Based on real-life experiences, issues, and soluti

Large boson number IBM calculations and their relationship to the Bohr model

International Nuclear Information System (INIS)

Thiamova, G.; Rowe, D.J.

2009-01-01

Recently, the SO(5) Clebsch-Gordan (CG) coefficients up to the seniority v max =40 were computed in floating point arithmetic (T.A. Welsh, unpublished (2008)); and, in exact arithmetic, as square roots of rational numbers (M.A. Caprio et al., to be published in Comput. Phys. Commun.). It is shown in this paper that extending the QQQ model calculations set up in the work by D.J. Rowe and G. Thiamova (Nucl. Phys. A 760, 59 (2005)) to N=v max =40 is sufficient to obtain the IBM results converged to its Bohr contraction limit. This will be done by comparing some important matrix elements in both models, by looking at the seniority decomposition of low-lying states and at the behavior of the energy and B(E2) transition strengths ratios with increasing seniority. (orig.)

A BASIC program for an IBM PC compatible computer for drawing the weak phase object contrast transfer function

International Nuclear Information System (INIS)

Olsen, A.; Skjerpe, P.

1989-01-01

This report describes a computer program which is useful in high resolution microscopy. The program is written in EBASIC and calculates the weak phase object contrast transfer function as function of instrumental and imaging parameters. The function is plotted on the PC graphics screen, and by a Print Screen command the function can be copied to the printer. The program runs on both the Hercules graphic card and the IBM CGA card. 2 figs

PRAAGE-1988: An interactive IBM-PC code for aging analysis of NUREG-1150 systems

International Nuclear Information System (INIS)

Fullwood, R.R.; Shier, W.G.

1988-01-01

Probabilistic Risk Assessments (PRA) contain a great deal of information for estimating the risk of a nuclear power plant but do not consider aging. PRAAGE (PRA+AGE) is an interactive, IBM-PC code for processing PRA-developed system models using non-aged failure rate data in conjunction with user-supplied time-dependent nuclear plant experience component failure rate data to determine the effects of component aging on a system's reliability as well as providing the age-dependent importances of various generic components. This paper describes the structure, use and application of PRAAGE to the aging analysis of the Peach Bottom 2 RHR system in the LPCI and SDC modes of operation. 4 refs., 15 figs., 5 tabs

Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody.

Science.gov (United States)

Ikeda, Keigo; Satoh, Minoru; Pauley, Kaleb M; Fritzler, Marvin J; Reeves, Westley H; Chan, Edward K L

2006-12-20

MicroRNAs (miRNAs) are short RNA molecules responsible for post-transcriptional gene silencing by the degradation or translational inhibition of their target messenger RNAs (mRNAs). This process of gene silencing, known as RNA interference (RNAi), is mediated by highly conserved Argonaute (Ago) proteins which are the key components of the RNA induced silencing complex (RISC). In humans, Ago2 is responsible for the endonuclease cleavage of targeted mRNA and it interacts with the mRNA-binding protein GW182, which is a marker for cytoplasmic foci referred to as GW bodies (GWBs). We demonstrated that the anti-Ago2 monoclonal antibody 4F9 recognized GWBs in a cell cycle dependent manner and was capable of capturing miRNAs associated with Ago2. Since Ago2 protein is the effector protein of RNAi, anti-Ago2 monoclonal antibody may be useful in capturing functional miRNAs.

GOSPEG-1 a program for routine analysis of γ-ray spectra by an in line IBM S/7 computer

International Nuclear Information System (INIS)

Godio, G.P.; Gozzellino, F.

1977-01-01

In this paper a program for routine analysis of γ-ray spectra of samples coming from irradiated nuclear fuel reprocessing plant is described. An IBM S/7 computer (SK words of memory) which is installed at the CNEN-EUREX reprocessing plant and which is in-line connected with a multichannel analyzer and Ge(Li) detector, has been utilized for this work. The program has been written in Assembler S/7 language

Case study: IBM Watson Analytics cloud platform as Analytics-as-a-Service system for heart failure early detection

OpenAIRE

Guidi, Gabriele; Miniati, Roberto; Mazzola, Matteo; Iadanza, Ernesto

2016-01-01

In the recent years the progress in technology and the increasing availability of fast connections have produced a migration of functionalities in Information Technologies services, from static servers to distributed technologies. This article describes the main tools available on the market to perform Analytics as a Service (AaaS) using a cloud platform. It is also described a use case of IBM Watson Analytics, a cloud system for data analytics, applied to the following research scope: detect...

IBM PARENTING BAGI GURU DAN ORANG TUA PAUD DI KELURAHAN PUDAK PAYUNG SEMARANG

Directory of Open Access Journals (Sweden)

Retnaningdyastuti .

2015-09-01

Full Text Available Abstract Science and technology program for the community (IbM aims to provide teachers and parents knowledges and skills in educating early childhood, especially in the form of parenting and child counseling. The methods used in the implementation of community service activities on developing character of early childhood through modeling and and habituation in the form of counseling and mentoring, such as playing games involving both parents and children. The result shows that the implementation of early childhood education has good responses from the participants. Through habituation and modeling given by teachers/ educators and parents, the activities can convey moral messages to children. Hopefully the children can be developed to have intelligent and healthy personality, and virtuous character. Keywords: early childhood education, parenting, and child counseling

Interest in smart metering project surprises utility, IBM

International Nuclear Information System (INIS)

Horne, D.

2006-01-01

This article provided an outline of Hydro Ottawa and IBM's smart metering pilot project, which has resulted in high approval ratings from the public. The project features 375 participants broken down into 3 separate groups to look for potential consumption differences between customers charged according to standard time-of-use pricing; time-of-use with critical peak pricing; and time-of-use with critical peak rebates. The Ontario Smart Price Pilot project will be run for 5 months, and is expected to provide detailed energy information about usage. Past projects have indicated that customers respond quickly to smart metering, as they are able to monitor their energy usage and more effectively manage their energy consumption. Ontario plans to have all homes and small businesses using smart meters by 2010, as high seasonal demand has indicated that conservation and balanced resource use are now top priorities for many utility companies. At least 10 states in the United States have conducted smart metering pilot projects. The California Public Utilities Commissions has recently approved a $1.7 billion statewide plan to replace old meters with smart meters. In Ontario, customers have ordered 10,000 electricity monitors that Hydro One is giving away. It was concluded that research results from an earlier Hydro One demonstration project with 500 Ontario homeowners showed that real time electricity monitors can help homeowners reduce their consumption of electricity by up to 15 per cent. 4 figs

Plasmodium falciparum metacaspase PfMCA-1 triggers a z-VAD-fmk inhibitable protease to promote cell death.

Directory of Open Access Journals (Sweden)

Benoît Meslin

Full Text Available Activation of proteolytic cell death pathways may circumvent drug resistance in deadly protozoan parasites such as Plasmodium falciparum and Leishmania. To this end, it is important to define the cell death pathway(s in parasites and thus characterize proteases such as metacaspases (MCA, which have been reported to induce cell death in plants and Leishmania parasites. We, therefore, investigated whether the cell death function of MCA is conserved in different protozoan parasite species such as Plasmodium falciparum and Leishmania major, focusing on the substrate specificity and functional role in cell survival as compared to Saccharomyces cerevisae. Our results show that, similarly to Leishmania, Plasmodium MCA exhibits a calcium-dependent, arginine-specific protease activity and its expression in yeast induced growth inhibition as well as an 82% increase in cell death under oxidative stress, a situation encountered by parasites during the host or when exposed to drugs such as artemisins. Furthermore, we show that MCA cell death pathways in both Plasmodium and Leishmania, involve a z-VAD-fmk inhibitable protease. Our data provide evidence that MCA from both Leishmania and Plasmodium falciparum is able to induce cell death in stress conditions, where it specifically activates a downstream enzyme as part of a cell death pathway. This enzymatic activity is also induced by the antimalarial drug chloroquine in erythrocytic stages of Plasmodium falciparum. Interestingly, we found that blocking parasite cell death influences their drug sensitivity, a result which could be used to create therapeutic strategies that by-pass drug resistance mechanisms by acting directly on the innate pathways of protozoan cell death.

Non-targeted effects of ionising radiation. Proceedings of the RISC-RAD specialised training course

International Nuclear Information System (INIS)

Belyakov, O.V.

2008-12-01

The training course 'Non-targeted effects of ionising radiation' took place at the STUK, Radiation and Nuclear Safety Authority, Helsinki, Finland 14-16 February 2005. Proceeding of this course is collected in this volume. The idea of the course was to convene a number of scientists leading in the area of non-targeted effects of ionising radiation with the aim to outline their visions for the role of these effects and outline the future directions of radiation research on the basis of their expertise. The course was supported by the RISC-RAD IP FI6R-CT-2003-508842, Euratom specific programme for research and training on nuclear energy, 6th FP of the EC. The main objectives of the training course were: (1) to clarify the mechanisms of non-targeted effects, in particular, bystander effects, genomic instability and adaptive response; (2) to look if and how non-targeted effects modulate the cancer risk in the low dose region, and whether they relate to protective or harmful functions; (3) to clarify if ionising radiation can cause non-cancer diseases or beneficial effects at low and intermediate doses; (4) address the issue of individual susceptibility and other factors modifying non-targeted responses; (5) attempt to assess the relevance of non-targeted effects for radiation protection and to set the scientific basis for a modern, more realistic, radiation safety system; (6) and finally to contribute to the conceptualisation of a new paradigm in radiation biology that would cover both the classical direct (DNA-targeted) and non-targeted (indirect) effects

Portable regional cerebral blood flow system based on IBM PC/AT and microprocessor electronics

International Nuclear Information System (INIS)

Mun, S.K.; Mun, I.K.; Petite, J.; Cohan, S.L.; Fahey, F.H.

1986-01-01

A portable 16-channel reginal cerebral blood flow (rCBF) measuring system has been developed using an IBM PC/AT and new microelectronics to improve processing speed and portability. The detector electronics were developed by Scan Detectronics A/S of Denmark. The counter module contains 18 16-bit counters, each programmable in four different modes. The rate meter has three independent microprocessor controllers for rate meter functions, window controller, and channel controller. The detector electronics and detection parameters can be fully controlled by the host PC/AT. The menu-driven system (Better Basic) assists the operator at each step. The collected data from 16 channels can be processed automatically or postprocessed using more flexible and sophisticated techniques within 20 minutes. The headgear holding 16 sodium iodide detectors is fabricated by modifying a motorcycle helmet

Use of TOUGH2 on small computers

Energy Technology Data Exchange (ETDEWEB)

Antunez, E.; Pruess, K.; Moridis, G. [Lawrence Berkeley Laboratory, CA (United States)

1995-03-01

TOUGH2/PC has been tested extensively on different PC platforms (486-33, 486-66, Pentium-90), with encouraging results. TOUGH2 performance has also been tested in other 32-bit computers as the MacIntosh Quadra 800, and a workstation IBM RISC 6000. Results obtained with these machines are compared with PCs` performance. PC results for 3-D geothermal reservoir models are discussed, including: (a) a Cartesian; and (b) a geothermal reservoir model with 1,411 irregular grid blocks. Also discussed are the results of the TOUGH2-compiler performance tests conducted on small computer systems. Code modifications required to operate on 32-bit computers and its setup in each machine environment are described. It is concluded that in today`s market PCs provide the best price/performance alternative to conduct TOUGH2 numerical simulations.

Efficient universal quantum channel simulation in IBM's cloud quantum computer

Science.gov (United States)

Wei, Shi-Jie; Xin, Tao; Long, Gui-Lu

2018-07-01

The study of quantum channels is an important field and promises a wide range of applications, because any physical process can be represented as a quantum channel that transforms an initial state into a final state. Inspired by the method of performing non-unitary operators by the linear combination of unitary operations, we proposed a quantum algorithm for the simulation of the universal single-qubit channel, described by a convex combination of "quasi-extreme" channels corresponding to four Kraus operators, and is scalable to arbitrary higher dimension. We demonstrated the whole algorithm experimentally using the universal IBM cloud-based quantum computer and studied the properties of different qubit quantum channels. We illustrated the quantum capacity of the general qubit quantum channels, which quantifies the amount of quantum information that can be protected. The behavior of quantum capacity in different channels revealed which types of noise processes can support information transmission, and which types are too destructive to protect information. There was a general agreement between the theoretical predictions and the experiments, which strongly supports our method. By realizing the arbitrary qubit channel, this work provides a universally- accepted way to explore various properties of quantum channels and novel prospect for quantum communication.

Speakeasy-3 reference manual. Level MU. IBM OS/VS version

International Nuclear Information System (INIS)

Cohen, S.; Pieper, S.C.

1977-08-01

Speakeasy is a computer language designed to provide access to information stored in a computer. Ease of use, natural notation, and built-in capabilities for growth are important features of Speakeasy. The language is based on the concepts of arrays and matrices, and processes these as entities; the need for many of the loops necessary in other programing languages is thus eliminated. It has a large vocabulary (over 500 words) of functions and commands in the areas of array manipulation, matrix algebra including eigenanalysis, special mathematical functions, numerical integration and differentiation, statistics, graphics, and character processing. It can be used either in batch mode or interactively. This book is the primary reference manual for the Speakeasy language and presents a nearly complete description of its capabilities. The chapters deal with the use of Speakeasy as a ''super desk calculator,'' the construction and editing of Speakeasy programs, the ability to communicate with other programing languages, the construction of user-written additions to the language, and various other facets of Speakeasy. In addition, a complete listing of the Help Library, which contains brief descriptions of each of the Speakeasy functions or commands, is included. This edition applies to the Mu release of Speakeasy-3, and describes the IBM OS/VS version. 18 figures

Communication overhead on the Intel Paragon, IBM SP2 and Meiko CS-2

Science.gov (United States)

Bokhari, Shahid H.

1995-01-01

Interprocessor communication overhead is a crucial measure of the power of parallel computing systems-its impact can severely limit the performance of parallel programs. This report presents measurements of communication overhead on three contemporary commercial multicomputer systems: the Intel Paragon, the IBM SP2 and the Meiko CS-2. In each case the time to communicate between processors is presented as a function of message length. The time for global synchronization and memory access is discussed. The performance of these machines in emulating hypercubes and executing random pairwise exchanges is also investigated. It is shown that the interprocessor communication time depends heavily on the specific communication pattern required. These observations contradict the commonly held belief that communication overhead on contemporary machines is independent of the placement of tasks on processors. The information presented in this report permits the evaluation of the efficiency of parallel algorithm implementations against standard baselines.

Studies at IBM on anisotropy in single crystals of the high-temperature oxide superconductor Y1Ba2Cu3O7/sub -//sub x/ (invited)

International Nuclear Information System (INIS)

Gallagher, W.J.

1988-01-01

A series of studies carried out at IBM on the magnetic, transport, and optical properties of single crystal Y 1 Ba 2 Cu 3 O/sub 7-//sub x/ demonstrate the overriding importance of anisotropy in its superconducting and normal-state properties

How do environmental and behavioral factors impact ultraviolet radiation effects on health: the RISC-UV Project

Science.gov (United States)

Correa, M. P.; Godin-Beekmann, S.; Haeffelin, M.; Saiag, P.; Mahe, E.; Brogniez, C.; Dupont, J. C.; Pazmiño, A.; Auriol, F.; Bonnel, B.

2009-04-01

Introduction: RISC-UV is a research project on "Impact of climate change on ultraviolet radiation and risks for health", a research project in which physicists, meteorologists and physicians work together to assess the relative role played by environmental and behavioral factors in the UV-related diseases as skin cancer and vitamin D deficiency. Environmental factors are related to the role played by the alteration in intensity of UV radiation at the Earth's surface resulting from variation in several factors affected by climate change and human activities: stratospheric ozone, cloud cover, aerosols and the reflectivity of the surface. On the other hand, behavioral factors are related to the sun over/underexposure and the correct use of sun-protection (hats, caps, sunglasses, sunscreen lotion, etc.). RISC-UV is organized around three main areas: 1) Organization of a workshop, scheduled for January 2009, which aims to describe the state of the art in the subject within each community and define the requirements of pathologists for epidemiological studies; 2) A pilot study intended to evaluate the consistency between UV measurements delivered simultaneously by satellite-based instruments, ground instruments, radiometers and individual dosimeters. This study is based on measurements campaigns and an analysis of the long-term consistency of data series relating to UV radiation and associated parameters; and 3) Analysis of the weights of medical, behavioral and environmental parameters involved in skin carcinogenesis. A detailed description of these areas can be found in http://www.gisclimat.fr/Doc/GB/D_projects/RISC-UV_GB.html. This presentation focuses on the first results of the UV experimental measurements performed between September 8th and October 8th 2008 in Palaiseau, France (48.7˚ N; 2.2˚ E; 170m - Haeffelin et al., 2005). A second campaign is foreseen for the spring of 2009. The purpose of these campaigns is to obtain, analyze and quantitatively link the

AMDLIBF, IBM 360 Subroutine Library, Eigenvalues, Eigenvectors, Matrix Inversion

International Nuclear Information System (INIS)

Wang, Jesse Y.

1980-01-01

Description of problem or function: AMDLIBF is a subset of the IBM 360 Subroutine Library at the Applied Mathematics Division at Argonne. This subset includes library category F: Identification/Description: F152S F SYMINV: Invert sym. matrices, solve lin. systems; F154S A DOTP: Double plus precision accum. inner prod.; F156S F RAYCOR: Rayleigh corrections for eigenvalues; F161S F XTRADP: A fast extended precision inner product; F162S A XTRADP: Inner product of two DP real vectors; F202S F1 EIGEN: Eigen-system for real symmetric matrix; F203S F: Driver for F202S; F248S F RITZIT: Largest eigenvalue and vec. real sym. matrix; F261S F EIGINV: Inverse eigenvalue problem; F313S F CQZHES: Reduce cmplx matrices to upper Hess and tri; F314S F CQZVAL: Reduce complex matrix to upper Hess. form; F315S F CQZVEC: Eigenvectors of cmplx upper triang. syst.; F316S F CGG: Driver for complex general Eigen-problem; F402S F MATINV: Matrix inversion and sol. of linear eqns.; F403S F: Driver for F402S; F452S F CHOLLU,CHOLEQ: Sym. decomp. of pos. def. band matrices; F453S F MATINC: Inversion of complex matrices; F454S F CROUT: Solution of simultaneous linear equations; F455S F CROUTC: Sol. of simultaneous complex linear eqns.; F456S F1 DIAG: Integer preserving Gaussian elimination

IBM1, a JmjC domain-containing histone demethylase, is involved in the regulation of RNA-directed DNA methylation through the epigenetic control of RDR2 and DCL3 expression in Arabidopsis

Science.gov (United States)

Fan, Di; Dai, Yan; Wang, Xuncheng; Wang, Zhenjie; He, Hang; Yang, Hongchun; Cao, Ying; Deng, Xing Wang; Ma, Ligeng

2012-01-01

Small RNA-directed DNA methylation (RdDM) is an important epigenetic pathway in Arabidopsis that controls the expression of multiple genes and several developmental processes. RNA-DEPENDENT RNA POLYMERASE 2 (RDR2) and DICER-LIKE 3 (DCL3) are necessary factors in 24-nt small interfering RNA (siRNA) biogenesis, which is part of the RdDM pathway. Here, we found that Increase in BONSAI Methylation 1 (IBM1), a conserved JmjC family histone demethylase, is directly associated with RDR2 and DCL3 chromatin. The mutation of IBM1 induced the hypermethylation of H3K9 and DNA non-CG sites within RDR2 and DCL3, which repressed their expression. A genome-wide analysis suggested that the reduction in RDR2 and DCL3 expression affected siRNA biogenesis in a locus-specific manner and disrupted RdDM-directed gene repression. Together, our results suggest that IBM1 regulates gene expression through two distinct pathways: direct association to protect genes from silencing by preventing the coupling of histone and DNA methylation, and indirect silencing of gene expression through RdDM-directed repression. PMID:22772985

IBM Software Defined Storage and ownCloud Enterprise Editon - a perfect match for hyperscale Enterprise File Sync and Share

CERN Multimedia

CERN. Geneva

2014-01-01

IBM Software Defined Storage, in particular the technology offering codenamed Elastic Storage (based on GPFS technology) has proven to be an ideal match for Enterprise File Sync and Share (EFSS) solutions that need highly scalable storage. The presentation will provide insight into the integration of Elastic Storage with the ownCloud Enterprise Edition (based on Open Source technology) software that showed impressive scalability and performance metrics during a proof-of-concept phase of an installation that is supposed to serve 300000 users when fully deployed.

Preparation of development plan for the gas-condensate pool with the use of a high speed computer (IBM-1620)

Energy Technology Data Exchange (ETDEWEB)

Shirkovsky, A I; Kumar, S

1968-01-01

The computation of all the technical, technological, and economic figures for a gas supply system by using the High Speed Computer IBM-1620 is presented. The gas supply system consists of a gas-condensate pool (source) and main gas pipeline from the pool to the consumer. All necessary analytical equations for correlating geological, technological, and economic variables have been used. Results of calculations and recommendations for the most profitable variant are given. Effects of geological, technological, and technical factors upon the economic figures are also shown.

A program to operate the TSI electrical aerosol analyser using an IBM-PC microcomputer - technical background

International Nuclear Information System (INIS)

Horton, K.D.; Mitchell, J.P.; Snelling, K.W.

1988-02-01

A program has been written to enable the TSI Electrical Aerosol Analyser (EAA model 3030) to be operated using an IBM-PC microcomputer. Although much of the program is based on the software supplied by TSI Inc to collect and process data from the EAA, it incorporates numerous improvements including the option to operate the EAA automatically via a TSI Differential Mobility Particle Sizer interface. When compiled, the program enables the data reduction which takes into account the significant cross-channel sensitivity of the EAA, to be performed in about 30 seconds making it possible to use the EAA to monitor rapid changes in the behaviour of sub-micron aerosol particles. (author)

Index of French nuclear literature: IBM 360 programmes for preparing the permuted index of French titles

International Nuclear Information System (INIS)

Chonez, Nicole

1968-12-01

This report contains the assembly list, the flow chart and some comments about each of the IBM 360 assembler language programmes used for preparing one of the subject indexes contained in the bibliographical bulletin entitled: 'Index de la Litterature nucleaire francaise'; this bulletin has been produced by the French C.E.A. since 1968. Only the processing phases from the magnetic tape file of the bibliographical references, assumed correct, to the printing out of the permuted index obtained with the French titles of the documents on the tape are considered here. This permuted index has the peculiarity of automatically regrouping synonyms and certain grammatical variations of the words. (author) [fr

Modeling radiative transport in ICF plasmas on an IBM SP2 supercomputer

International Nuclear Information System (INIS)

Johansen, J.A.; MacFarlane, J.J.; Moses, G.A.

1995-01-01

At the University of Wisconsin-Madison the authors have integrated a collisional-radiative-equilibrium model into their CONRAD radiation-hydrodynamics code. This integrated package allows them to accurately simulate the transport processes involved in ICF plasmas; including the important effects of self-absorption of line-radiation. However, as they increase the amount of atomic structure utilized in their transport models, the computational demands increase nonlinearly. In an attempt to meet this increased computational demand, they have recently embarked on a mission to parallelize the CONRAD program. The parallel CONRAD development is being performed on an IBM SP2 supercomputer. The parallelism is based on a message passing paradigm, and is being implemented using PVM. At the present time they have determined that approximately 70% of the sequential program can be executed in parallel. Accordingly, they expect that the parallel version will yield a speedup on the order of three times that of the sequential version. This translates into only 10 hours of execution time for the parallel version, whereas the sequential version required 30 hours

Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates.

Science.gov (United States)

Flores-Jasso, C Fabián; Salomon, William E; Zamore, Phillip D

2013-02-01

Small interfering RNAs (siRNAs) direct Argonaute proteins, the core components of the RNA-induced silencing complex (RISC), to cleave complementary target RNAs. Here, we describe a method to purify active RISC containing a single, unique small RNA guide sequence. We begin by capturing RISC using a complementary 2'-O-methyl oligonucleotide tethered to beads. Unlike other methods that capture RISC but do not allow its recovery, our strategy purifies active, soluble RISC in good yield. The method takes advantage of the finding that RISC partially paired to a target through its siRNA guide dissociates more than 300 times faster than a fully paired siRNA in RISC. We use this strategy to purify fly Ago1- and Ago2-RISC, as well as mouse AGO2-RISC. The method can discriminate among RISCs programmed with different guide strands, making it possible to deplete and recover specific RISC populations. Endogenous microRNA:Argonaute complexes can also be purified from cell lysates. Our method scales readily and takes less than a day to complete.

AMDLIBGZ, IBM 360 Subroutine Library for Data Processing, Graphics, Sorting

International Nuclear Information System (INIS)

Wang, Jesse Y.

1980-01-01

Description of problem or function: AMDLIBGZ is a subset of the IBM 360 Subroutine Library at the Applied Mathematics Division at Argonne National Laboratory. This subset includes library categories G-Z: Identification/Description: G552S F RANF: Random number generator; J952S F YOLYPLOT: CalComp plots; J955S P GRAF: Prints a graph of points on line printer; K250S A1: Core to core conversion; K251S A HEXINP: Hexadecimal input for PL/I programs; K252S A HEXOUT: Hexadecimal output conv. PL/I programs; M101S F SORT: Algebraic sort; M150S F CSORT: Algebraic sort; M151S P2 ANLKWIC: KWIC sort; M250S A SMALLIST: Squeezes assembler listing to 8 x 11; N251S A ABEND: Calls ABEND dump; Q052S A CLOCK: Time; Q053S A COPYAGO: Copy load module from tape to disk; Q054S A DATE: Current date in form MM/DD/YY; Q055S A TIME: Time (24 hour clock) in EBCDIC HH.MM.SS; Z013S F: Variable metric minimization; Z057S A LOCF: Locate machine addresses of variables; Z071S A ALLOC: Allocate LCS for FORTRAN programs; Z074S A ANLMNP: Exponent and mantissa manipulative functs.

From Electrons Paired to Electric Power Delivered- A Personal Journey in Research and Applications of Superconductivity at IBM, EPRI, and Beyond

Science.gov (United States)

Grant, Paul

2014-03-01

This talk will reprise a personal journey by the speaker in industrial and applied physics, commencing with his employment by IBM at age 17 in the early 1950s, and continuing through his corporate sponsored undergraduate and graduate years at Clarkson and Harvard Universities, resulting in 1965 in a doctorate in applied physics from the latter. He was subsequently assigned by IBM to its research division in San Jose (now Almaden), where he initially carried out both pure and applied theoretical and experimental investigations encompassing a broad range of company-related product technologies...storage, display, printer and data acquisition hardware and software. In 1973, he undertook performing DFT and quantum Monte Carlo calculations in support of group research in the then emerging field of organic and polymer superconductors, a very esoteric pursuit at the time. Following upon several corporate staff assignments involving various product development and sales strategies, in 1982 he was appointed manager of the cooperative phenomena group in the Almaden Research Center, which beginning in early 1987, made significant contributions to both the basic science and applications of high temperature superconductivity (HTSC). In 1993, after a 40-year career, he retired from IBM to accept a Science Fellow position at the Electric Power Research Institute (EPRI) where he funded power application development of superconductivity. In 2004, he retired from his EPRI career to undertake ``due diligence'' consulting services in support of the venture capital community in Silicon Valley. As a ``hobby,'' he currently pursues and publishes DFT studies in hope of discovering the pairing mechanism of HTSC. In summary, the speaker's career in industrial and applied physics demonstrates one can combine publishing a record three PRLs in one month with crawling around underground in substations with utility lineman helping install superconducting cables, along the way publishing 10

First experimental results from IBM/TENN/TULANE/LLNL/LBL undulator beamline at the advanced light source

International Nuclear Information System (INIS)

Jia, J.J.; Callcott, T.A.; Yurkas, J.; Ellis, A.W.; Himpsel, F.J.; Samant, M.G.; Stoehr, J.; Ederer, D.L.; Carlisle, J.A.; Hudson, E.A.; Terminello, L.J.; Shuh, D.K.; Perera, R.C.C.

1995-01-01

The IBM/TENN/TULANE/LLNL/LBL Beamline 8.0 at the advanced light source combining a 5.0 cm, 89 period undulator with a high-throughput, high-resolution spherical grating monochromator, provides a powerful excitation source over a spectral range of 70--1200 eV for surface physics and material science research. The beamline progress and the first experimental results obtained with a fluorescence end station on graphite and titanium oxides are presented here. The dispersive features in K emission spectra of graphite excited near threshold, and found a clear relationship between them and graphite band structure are observed. The monochromator is operated at a resolving power of roughly 2000, while the spectrometer has a resolving power of 400 for these fluorescence experiments

Interactive nuclear plant analyzer for the VVER-440 reactor

International Nuclear Information System (INIS)

Shier, W.; Kennett, R.

1993-01-01

An interactive nuclear plant analyzer (NPA) has been developed for a VVER-440 model 213 reactor for use in the training of plant personnel, the development and verification of plant operating procedures, and in the analysis of various anticipated operational occurrences and accident scenarios. This NPA is operational on an IBM RISC-6000 workstation and utilizes the RELAP5/MOD2 computer code for the calculation of the VVER-440 reactor response to the interactive commands initiated by the NPA operator. Results of the interactive calculation can be through the user-defined, digital display of various plant parameters and through color changes that reflect changes in primary system fluid temperatures, fuel and clad temperatures, and the temperatures of other metal structures. In addition, changes in the status of various components and system can be initiated and/or displayed both numerically and graphically on the mask

A Monte Carlo program for calculating high energy spectra in cylindrical geometry on the IBM 709 computer

Energy Technology Data Exchange (ETDEWEB)

Francescon, S [Computer Branch, Technical Assessments and Services Division, Atomic Energy Establishment, Winfrith, Dorchester, Dorset (United Kingdom)

1960-10-15

The report describes an I.B.M. 709 program written at the request of the Reactor Division, Harwell, to obtain high energy spectra in a system containing a number of fissile and non-fissile materials, arranged as concentric cylinders of infinite length surrounded by an outer material with a square or rectangular boundary. At the cell boundary neutrons can be lost by leakage or reflected back into the system. A specified number of fission neutrons born in the fissile materials, together with any descendants they may have, are tracked one by one through the system until they are absorbed, lost by leakage through the lattice boundary, or their energies have fallen below a specifiable cut-off energy. The neutrons may be started from anywhere in the system and all neutron-nucleus reactions that occur in the nuclides supplied with the program are allowed. A descriptions is given of the use of the program, the current version of which is available as a self-loading binary tape which contains, in addition to the program, all the nuclear data at present available. Binary card decks are also available and nuclear data for other nuclides can be added. A feature of the program is the flexibility with which the core storage available for input and output data can be allocated according to the requirements of the problem. The output of the program is in the form of a Binary Coded Decimal tape (B.C.D.) which can be used on the normal I.B.M. off-line equipment to print out the results. An example is given of the results obtained for use in radiation damage calculations of the spatial distribution of neutrons in a simple uranium-D{sub 2}O system.

Prenatal vitamin A deficiency impairs adaptive immune responses to pentavalent rotavirus vaccine (RotaTeq®) in a neonatal gnotobiotic pig model.

Science.gov (United States)

Kandasamy, Sukumar; Chattha, Kuldeep S; Vlasova, Anastasia N; Saif, Linda J

2014-02-07

Vitamin A deficiency (VAD) is associated with increased childhood mortality and morbidity in impoverished Asian and African countries, but the impact of VAD on rotavirus (RV) vaccine or infection is poorly understood. We assessed effects of gestational and dietary induced pre- and post-natal VAD and vitamin A supplementation on immune responses to a pentavalent rotavirus vaccine, RotaTeq(®) in a neonatal gnotobiotic pig model. Vaccine efficacy was assessed against virulent G1P[8] human rotavirus (HRV) challenge. VAD and vitamin A sufficient (VAS) piglets were derived from dietary VAD and VAS sows, respectively. VAD piglets had significantly lower levels of hepatic vitamin A compared to that of VAS piglets. RotaTeq(®)-vaccinated VAD piglets had 350-fold higher fecal virus shedding titers compared to vaccinated VAS piglets post-challenge. Only 25% of vaccinated non-vitamin A supplemented VAD piglets were protected against diarrhea compared with 100% protection rate in vaccinated non-supplemented VAS piglets post-challenge. Intestinal HRV specific immune responses were compromised in VAD piglets. Vaccinated VAD piglets had significantly lower ileal HRV IgG antibody secreting cell (ASC) responses (pre-challenge) and duodenal HRV IgA ASC responses (post-challenge) compared to vaccinated VAS piglets. Also, intestinal HRV IgA antibody titers were 11-fold lower in vaccinated VAD compared to vaccinated VAS piglets post-challenge. Persistently elevated levels of IL-8, a pro-inflammatory mediator, and lower IL-10 responses (anti-inflammatory) in vaccinated VAD compared to VAS piglets suggest more severe inflammatory responses in VAD piglets post-challenge. Moreover higher IFN-γ responses pre-challenge were observed in VAD compared to VAS piglets. The impaired vaccine-specific intestinal antibody responses and decreased immunoregulatory cytokine responses coincided with reduced protective efficacy of the RV vaccine against virulent HRV challenge in VAD piglets. In

EU:s nya varumärkesdefinition : En utredning av vad borttagandet av kravet på grafisk återgivning kommer att innebära för möjligheten att registrera okonventionella varumärken

OpenAIRE

Fredriksson, Mathilda; Petersson, Frida

2017-01-01

Sedan det första steget togs mot en harmoniserad varumärkesrätt inom EU har grafisk återgivning varit ett krav vid registrering av varumärken, men kravet på grafisk återgivning försvinner i och med EU:s nya varumärkesreform. Syftet med denna uppsats är att belysa och utreda vad detta kommer att innebära för möjligheten att registrera okonventionella varumärken. Utredningen är inriktad på följande okonventionella varumärken: doftmärken, smakmärken, ljudmärken, känselmärken, rörelsemärken och h...

GPIB interface of IBM-PC compatible microcomputer and multimeter HP3457A for the automatization of temperature measurements

International Nuclear Information System (INIS)

Migliano, A.C.C.; Sircilli Neto, F.; Passaro, A.

1990-01-01

The measurement of temperature distribution of the beam transport devices, utilized in the IEAv linac, takes several hours to be completed. At the beam transport laboratory, these experiments are controlled with the help of a MS-quick BASIC code denominated TERMOJ. This code uses the software of STD-8410 plate to promote the communication between an IBM-PC compatible microcomputer and the programmable multimeter HP3457A via GPIB interface. This work presents information for the automation of experiments using thermocouples to obtain temperature distributions with the TERMOJ code. Also, suggestions of how modify the algorithm of the program for the specific situations are indicated. (author)

Determination of performance characteristics of scientific applications on IBM Blue Gene/Q

Energy Technology Data Exchange (ETDEWEB)

Evangelinos, C. [IBM Research Division, Cambridge, MA (United States); Walkup, R. E. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Sachdeva, V. [IBM Research Division, Cambridge, MA (United States); Jordan, K. E. [IBM Research Division, Cambridge, MA (United States); Gahvari, H. [Univ. of Illinois, Urbana-Champaign, IL (United States). Computer Science Dept.; Chung, I. -H. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Perrone, M. P. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Lu, L. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Liu, L. -K. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Magerlein, K. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center

2013-02-13

The IBM Blue Gene®/Q platform presents scientists and engineers with a rich set of hardware features such as 16 cores per chip sharing a Level 2 cache, a wide SIMD (single-instruction, multiple-data) unit, a five-dimensional torus network, and hardware support for collective operations. Especially important is the feature related to cores that have four “hardware threads,” which makes it possible to hide latencies and obtain a high fraction of the peak issue rate from each core. All of these hardware resources present unique performance-tuning opportunities on Blue Gene/Q. We provide an overview of several important applications and solvers and study them on Blue Gene/Q using performance counters and Message Passing Interface profiles. We also discuss how Blue Gene/Q tools help us understand the interaction of the application with the hardware and software layers and provide guidance for optimization. Furthermore, on the basis of our analysis, we discuss code improvement strategies targeting Blue Gene/Q. Information about how these algorithms map to the Blue Gene® architecture is expected to have an impact on future system design as we move to the exascale era.

Maintenance Manual for AUDIT. A System for Analyzing SESCOMP Software. Volume 4: Appendix D. Listings of the AUDIT Software for the IBM 360.

Science.gov (United States)

1977-08-01

The AUDIT documentation provides the maintenance programmer personnel with the information to effectively maintain and use the AUDIT software. The ...SESCOMPSPEC’s) and produces reports detailing the deviations from those standards. The AUDIT software also examines a program unit to detect and report...changes in word length on the output of computer programs. This report contains the listings of the AUDIT software for the IBM 360. (Author)

Numerical analysis of resonances induced by s wave neutrons in transmission time-of-flight experiments with a computer IBM 7094 II; Methodes d'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol et automatisation de ces methodes sur ordinateur IBM 7094 II

Energy Technology Data Exchange (ETDEWEB)

Corge, Ch [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-01-01

Numerical analysis of transmission resonances induced by s wave neutrons in time-of-flight experiments can be achieved in a fairly automatic way on an IBM 7094/II computer. The involved computations are carried out following a four step scheme: 1 - experimental raw data are processed to obtain the resonant transmissions, 2 - values of experimental quantities for each resonance are derived from the above transmissions, 3 - resonance parameters are determined using a least square method to solve the over determined system obtained by equalling theoretical functions to the correspondent experimental values. Four analysis methods are gathered in the same code, 4 - graphical control of the results is performed. (author) [French] L'automatisation, sur ordinateur IBM 7094/II, de l'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol a ete accomplie en la decomposant selon un schema articule en quatre phases: 1 - le traitement des donnees experimentales brutes pour obtenir les transmissions interfero-resonnantes, 2 - la determination des grandeurs d'analyse a partir des transmissions precedentes, 3 - l'analyse proprement dite des resonances dont les parametres sont obtenus par la resolution d'un systeme surabondant. Quatre methodes d'analyse sont groupees en un meme programme, 4 - la procedure de verification graphique. (auteur)

Solar energy system performance evaluation report for IBM System 4 at Clinton, Mississippi

Science.gov (United States)

1980-07-01

The IBM System 4 Solar Energy System is described and evaluated. The system was designed to provide 35 percent of the space heating and 63 percent of the domestic hot water preheating for a single family residence located within the United States. The system consists of 259 square feet of flat plate air collectors, a rock thermal storage containing 5 1/2 ton of rock, heat exchangers, blowers, a 52 gallon preheat tank, controls, and associated plumbing. In general, the performance of the system did not meet design expectations, since the overall design solar fraction was 48 percent and the measured value was 32 percent. Although the measured space heating solar fraction at 32 percent did agree favorably with the design space heating solar fraction at 35 percent, the hot water measured solar fraction at 33 percent did not agree favorably with the design hot water solar fraction of 63 percent. In particular collector array air leakage, dust covered collectors, abnormal hot water demand, and the preheat tank by pass valve problem are main reasons for the lower performance.

Ventricular assist device elicits serum natural IgG that correlates with the development of primary graft dysfunction following heart transplantation.

Science.gov (United States)

See, Sarah B; Clerkin, Kevin J; Kennel, Peter J; Zhang, Feifan; Weber, Matthew P; Rogers, Kortney J; Chatterjee, Debanjana; Vasilescu, Elena R; Vlad, George; Naka, Yoshifumi; Restaino, Susan W; Farr, Maryjane A; Topkara, Veli K; Colombo, Paolo C; Mancini, Donna M; Schulze, P Christian; Levin, Bruce; Zorn, Emmanuel

2017-08-01

Pre-transplant sensitization is a limiting factor in solid-organ transplantation. In heart transplants, ventricular assist device (VAD) implantation has been associated with sensitization to human leukocyte antigens (HLA). The effect of VAD on non-HLA antibodies is unclear. We have previously shown that polyreactive natural antibodies (Nabs) contribute to pre-sensitization in kidney allograft recipients. Here we assessed generation of Nabs after VAD implantation in pre-transplant sera and examined their contribution to cardiac allograft outcome. IgM and IgG Nabs were tested in pre-transplant serum samples collected from 206 orthotopic heart transplant recipients, including 128 patients with VAD (VAD patients) and 78 patients without VAD (no-VAD patients). Nabs were assessed by testing serum reactivity to apoptotic cells by flow cytometry and to the generic oxidized epitope, malondialdehyde, by enzyme-linked immunosorbent assay. No difference was observed in serum levels of IgM Nabs between VAD and no-VAD patients. However, serum IgG Nabs levels were significantly increased in VAD compared with no-VAD patients. This increase was likely due to the presence of the VAD, as revealed by lower serum IgG Nabs levels before implantation. Elevated pre-transplant IgG Nabs level was associated with development of primary graft dysfunction (PGD). Our study demonstrates that VAD support elicits IgG Nabs reactive to apoptotic cells and oxidized epitopes. These findings further support broad and non-specific B-cell activation by VAD, resulting in IgG sensitization. Moreover, the association of serum IgG Nabs levels with development of PGD suggests a possible role for these antibodies in the inflammatory reaction accompanying this complication. Copyright © 2017 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

FROM THE LEWIS AND CLARK EXPEDITION TO IBM, DELL, AND SOUTHWEST AIRLINES: TEACHING HISTORY AND LEADERSHIP TO BUSINESS STUDENTS

Directory of Open Access Journals (Sweden)

Jeffrey J. Matthews

2006-01-01

Full Text Available History is not a tomb of dead facts but a resource that can inform and improve everyday decision making. Experience as an analytical tool is invaluable for solving problems in changing and competitive environments. “From the Lewis and Clark Expedition,” which coincides with the National Lewis & Clark Bicentennial Commemoration (2003—2006, demonstrates how contemporary business concepts of visionary leadership, systematic planning, and organizational climate were instrumental to the success of Thomas Jefferson's “Corps of Discovery” and shows how a mastery of these concepts contributed to the successes of the pioneering US corporations IBM, Southwest Airlines, and Dell.

Numerical analysis of resonances induced by s wave neutrons in transmission time-of-flight experiments with a computer IBM 7094 II; Methodes d'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol et automatisation de ces methodes sur ordinateur IBM 7094 II

Energy Technology Data Exchange (ETDEWEB)

Corge, Ch. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-01-01

Numerical analysis of transmission resonances induced by s wave neutrons in time-of-flight experiments can be achieved in a fairly automatic way on an IBM 7094/II computer. The involved computations are carried out following a four step scheme: 1 - experimental raw data are processed to obtain the resonant transmissions, 2 - values of experimental quantities for each resonance are derived from the above transmissions, 3 - resonance parameters are determined using a least square method to solve the over determined system obtained by equalling theoretical functions to the correspondent experimental values. Four analysis methods are gathered in the same code, 4 - graphical control of the results is performed. (author) [French] L'automatisation, sur ordinateur IBM 7094/II, de l'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol a ete accomplie en la decomposant selon un schema articule en quatre phases: 1 - le traitement des donnees experimentales brutes pour obtenir les transmissions interfero-resonnantes, 2 - la determination des grandeurs d'analyse a partir des transmissions precedentes, 3 - l'analyse proprement dite des resonances dont les parametres sont obtenus par la resolution d'un systeme surabondant. Quatre methodes d'analyse sont groupees en un meme programme, 4 - la procedure de verification graphique. (auteur)

Institutional Plan FY 1999-2003

Energy Technology Data Exchange (ETDEWEB)

Hughes, P.J.

1999-02-08

Computational science is becoming an increasingly important component of Pacific Northwest's support to DOE's major missions. The advanced parallel computing systems in the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL), coupled with new modeling and simulation software, data management tools, and user interfaces, are providing solutions to previously intractable problems. Research focuses on developing software and other tools to address computational challenges in molecular science, environmental management, global climate change, advanced materials and manufacturing processes, molecular biology, and information management. The Graphics and Visualization Laboratory is part of EMSL'S Molecular Science Computing Facility (MSCF). The MSCF contains a 512-processor IBM RISC System/6000 scalable power parallel computer system that provides the advanced computing capability needed to address ''Grand Challenge'' environmental research problems. The MSCF provides an integrated computing environment with links to facilities in the DOE complex, universities, and industry. The image inserts are graphical representations of simulations performed with software developed at the Laboratory.

Single-center experience of the bridge-to-bridge strategy using the Nipro paracorporeal ventricular assist device.

Science.gov (United States)

Yoshitake, Shuichi; Kinoshita, Osamu; Nawata, Kan; Hoshino, Yasuhiro; Itoda, Yoshifumi; Kimura, Mitsutoshi; Yamauchi, Haruo; Ono, Minoru

2018-06-25

Currently, we use the Nipro paracorporeal VAD (p-VAD) for initial short-term ventricular support, as a bridge to decision (BTD) or a bridge to candidacy (BTC) treatment, in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) levels 1 and 2 patients. However, it is possible that compared to patients with primary implantable-VADs (P-iVAD), the bridge-to-bridge (BTB) patients are more likely to develop complications. This retrospective study used data from 24 consecutive BTB patients who were initially implanted with Nipro p-VAD as BTD or BTC treatments between April 2011 and March 2016, and subsequently underwent conversion to an i-VAD. The data from 72 patients who underwent a primary i-VAD (P-iVAD) procedure were used for comparison. Between the two groups, there was no significant difference in the incidence of infectious events (p = 0.72) or stroke (p = 0.44). Orthotropic heart transplantation was performed in 6 of the 24 patients in the BTB group and in 21 of the 72 patients in the P-iVAD group. The 1- and 2-year survival rates were 95.8% and 95.8% in the BTB group and 91% and 85.8% in the P-iVAD group; these values were not significantly different between groups (p = 0.91). Based on these results we conclude that BTB using Nipro p-VAD is a reasonable strategy for treating patients with severe decompensated end-stage heart failure.

The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading.

Science.gov (United States)

Tarallo, Roberta; Giurato, Giorgio; Bruno, Giuseppina; Ravo, Maria; Rizzo, Francesca; Salvati, Annamaria; Ricciardi, Luca; Marchese, Giovanna; Cordella, Angela; Rocco, Teresa; Gigantino, Valerio; Pierri, Biancamaria; Cimmino, Giovanni; Milanesi, Luciano; Ambrosino, Concetta; Nyman, Tuula A; Nassa, Giovanni; Weisz, Alessandro

2017-10-06

The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing. Estrogen receptor beta (ERβ) is endowed with oncosuppressive activities, antagonizing hormone-induced carcinogenesis and inhibiting growth and oncogenic functions in luminal-like breast cancers (BCs), where its expression correlates with a better prognosis of the disease. Applying interaction proteomics coupled to mass spectrometry to characterize nuclear factors cooperating with ERβ in gene regulation, we identify AGO2 as a novel partner of ERβ in human BC cells. ERβ-AGO2 association was confirmed in vitro and in vivo in both the nucleus and cytoplasm and is shown to be RNA-mediated. ChIP-Seq demonstrates AGO2 association with a large number of ERβ binding sites, and total and nascent RNA-Seq in ERβ + vs ERβ - cells, and before and after AGO2 knock-down in ERβ + cells, reveals a widespread involvement of this factor in ERβ-mediated regulation of gene transcription rate and RNA splicing. Moreover, isolation and sequencing by RIP-Seq of ERβ-associated long and small RNAs in the cytoplasm suggests involvement of the nuclear receptor in RISC loading, indicating that it may also be able to directly control mRNA translation efficiency and stability. These results demonstrate that AGO2 can act as a pleiotropic functional partner of ERβ, indicating that both factors are endowed with multiple roles in the control of key cellular functions.

Vad är den främst avgörande faktorn vid privatkundens val av marginalbank? : en studie om hur demografiska skillnader påverkar privatkunders val av marginalbank samt se hur deras val kan användas vid segmentering

OpenAIRE

Lindh, Jenni; Persson, Frida

2012-01-01

Syfte: Syftet med detta examensarbete är att förklara vad som är den främst avgörande faktorn vid privatkundens val av marginalbank, genom att jämföra med demografiska variabler samt hur deras val kan användas vid segmentering. Dessutom vill vi titta på vilka typer av banker privatkunder har. Metod: För att nå fram till resultat för analysen har ett positivistiskt angreppssätt och en deduktiv ansats använts. Det empiriska materialet är baserat på en enkätundersökning gjord på personer i Hässl...

RELAP5/MOD2 implementation on various mainframes including the IBM and SX-2 supercomputer

International Nuclear Information System (INIS)

DeForest, D.L.; Hassan, Y.A.

1987-01-01

The RELAP5/MOD2 (cycle 36.04) code is a one-dimensional, two-fluid, nonequilibrium, nonhomogeneous transient analysis code designed to simulate operational and accident scenarios in pressurized water reactors (PWRs). System models are solved using a semi-implicit finite difference method. The code was developed at EG and G in Idaho Falls under sponsorship of the US Nuclear Regulatory Commission (NRC). The major enhancement from RELAP5/MOD1 is the use of a six-equation, two-fluid nonequilibrium and nonhomogeneous model. Other improvements include the addition of a noncondensible gas component and the revision and addition of drag formulation, wall friction, and wall heat transfer. Several test cases were run to benchmark the IBM and SX-2 installations against the CDC computer and the CRAY-2 and CRAY/XMP. These included the Edward's pipe blow-down and two separate reflood cases developed to simulate the FLECHT-SEASET reflood test 31504 and a postcritical heat flux (CHF) test performed at Lehigh University

The microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cells.

Science.gov (United States)

Moser, Joanna J; Fritzler, Marvin J

2010-10-18

GW/P bodies are cytoplasmic ribonucleoprotein-rich foci involved in microRNA (miRNA)-mediated messenger RNA (mRNA) silencing and degradation. The mRNA regulatory functions within GW/P bodies are mediated by GW182 and its binding partner hAgo2 that bind miRNA in the RNA-induced silencing complex (RISC). To date there are no published reports of the profile of miRNA and mRNA targeted to the RISC or a comparison of the RISC-specific miRNA/mRNA profile differences in malignant and non-malignant cells. RISC mRNA and miRNA components were profiled by microarray analysis of malignant human U-87 astrocytoma cells and its non-malignant counterpart, primary human astrocytes. Total cell RNA as well as RNA from immunoprecipitated RISC was analyzed. The novel findings were fourfold: (1) miRNAs were highly enriched in astrocyte RISC compared to U-87 astrocytoma RISC, (2) astrocytoma and primary astrocyte cells each contained unique RISC miRNA profiles as compared to their respective cellular miRNA profiles, (3) miR-195, 10b, 29b, 19b, 34a and 455-3p levels were increased and the miR-181b level was decreased in U-87 astrocytoma RISC as compared to astrocyte RISC, and (4) the RISC contained decreased levels of mRNAs in primary astrocyte and U-87 astrocytoma cells. The observation that miR-34a and miR-195 levels were increased in the RISC of U-87 astrocytoma cells suggests an oncogenic role for these miRNAs. Differential regulation of mRNAs by specific miRNAs is evidenced by the observation that three miR34a-targeted mRNAs and two miR-195-targeted mRNAs were downregulated while one miR-195-targeted mRNA was upregulated. Biological pathway analysis of RISC mRNA components suggests that the RISC plays a pivotal role in malignancy and other conditions. This study points to the importance of the RISC and ultimately GW/P body composition and function in miRNA and mRNA deregulation in astrocytoma cells and possibly in other malignancies.

The microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cells.

Directory of Open Access Journals (Sweden)

Joanna J Moser

2010-10-01

Full Text Available GW/P bodies are cytoplasmic ribonucleoprotein-rich foci involved in microRNA (miRNA-mediated messenger RNA (mRNA silencing and degradation. The mRNA regulatory functions within GW/P bodies are mediated by GW182 and its binding partner hAgo2 that bind miRNA in the RNA-induced silencing complex (RISC. To date there are no published reports of the profile of miRNA and mRNA targeted to the RISC or a comparison of the RISC-specific miRNA/mRNA profile differences in malignant and non-malignant cells.RISC mRNA and miRNA components were profiled by microarray analysis of malignant human U-87 astrocytoma cells and its non-malignant counterpart, primary human astrocytes. Total cell RNA as well as RNA from immunoprecipitated RISC was analyzed. The novel findings were fourfold: (1 miRNAs were highly enriched in astrocyte RISC compared to U-87 astrocytoma RISC, (2 astrocytoma and primary astrocyte cells each contained unique RISC miRNA profiles as compared to their respective cellular miRNA profiles, (3 miR-195, 10b, 29b, 19b, 34a and 455-3p levels were increased and the miR-181b level was decreased in U-87 astrocytoma RISC as compared to astrocyte RISC, and (4 the RISC contained decreased levels of mRNAs in primary astrocyte and U-87 astrocytoma cells.The observation that miR-34a and miR-195 levels were increased in the RISC of U-87 astrocytoma cells suggests an oncogenic role for these miRNAs. Differential regulation of mRNAs by specific miRNAs is evidenced by the observation that three miR34a-targeted mRNAs and two miR-195-targeted mRNAs were downregulated while one miR-195-targeted mRNA was upregulated. Biological pathway analysis of RISC mRNA components suggests that the RISC plays a pivotal role in malignancy and other conditions. This study points to the importance of the RISC and ultimately GW/P body composition and function in miRNA and mRNA deregulation in astrocytoma cells and possibly in other malignancies.

Theoretical aspects of neutron interaction: part 1 - interaction programme for ibm 7094, part 2 - the shielding sub-programme, part 3 - listing of the programme; Aspects theoriques de l'interaction neutronique: annexe 1 - programme interaction pour ibm 7094 - annexe 2 - sous programme ombre - annexe 3 - liste du programme

Energy Technology Data Exchange (ETDEWEB)

Moret-Bailly, J; Penet, F; Spinelli, J C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1965-07-01

Part I. Methods are described for obtaining the equations for a system of elements containing fissile matter: a) by using the balance after fission, b) by using the balance before fission, c) by the evolution equations. All these methods lead to equivalent matrices whose greatest proper value is the multiplication coefficient for the system K. It is shown how to calculate K. From this it is possible to deduce the rules which generalize the criterion for the bounded solid angle. An IBM 7094 programme applies this theory to the calculation of the installations made up of a maximum of 500 elements. It calculates the effective values of K, the leaks, the solid angles and then K. Part. II. This sub-programme calculates the shielding between the elements. (authors) [French] Sommaire, - Annexe I. On expose les methodes permettant d'obtenir les equations d'un systeme d'elements contenant de la matiere fissile: a) par le bilan apres fission, b) par le bilan avant fission, c) par les equations d'evolution. Toutes ces methodes conduisent a des matrices equivalentes dont la plus grande valeur propre est le coefficient de multiplication de l'ensemble K. On montre comment K se calcule. On en deduit des regles qui generalisent le critere de l'angle solide limite. Un programme pour IBM 7094 applique cette theorie au calcul des installations comportant au maximum 500 elements. II calcule les k effectifs, les fuites, les angles solides puis K. Annexe II. Ce sous-programme calcule les ombres entre les elements. (auteurs)

Simulation of the Mitra 15 micro-machine on IBM 360/91. Microprogramming of the fast Fourier transform

International Nuclear Information System (INIS)

Augustides, Jean

1973-01-01

As computing time did not allow working in real time, and as different methods had been proposed to reduce the computing time (the Cooley-Tuckey method, the use of specific FFT processors), this thesis proposes an intermediate solution, between the entirely programmed solution and the entirely cabled solution. After some generalities on micro-programming (definition, history, benefits and drawbacks, perspectives), the author reports the micro-programming of the Mitra 15 micro-machine: description of the machine, memory, command memory and associated circuits, interruptions and suspensions, descriptions of micro-statements, execution of a micro-statement. Programs and subroutines developed for the modelling of Mitra 15 micro-machine on IBM 360/91 are presented. Then, the author reports the micro-programming of the fast Fourier transform: theory, program description, and test

Solar energy system performance evaluation: Seasonal report for IBM system 1A, Huntsville, Alabama

Science.gov (United States)

1980-01-01

The operational and thermal performance of the solar energy system, Sims Prototype System 1A, is described. The system was designed by IBM to provide 50 to 60 percent of the space heating and domestic hot water preheating load to a 2,000 square foot floor space single family residence in the Huntsville area. The load design temperature inside the building was to be maintained at 70 degrees fahrenheit with auxiliary energy for heating supplied by an electric heat pump assisted by an electric resistance strip heater. In general the disappointing operation of this system is attributed to the manner in which it was used. The system was designed for residential application and used to satisfy the demands of an office environment. The differences were: (1) inside temperature was not maintained at 70 F as expected; and (2) hot water usage was much lower than expected. The conclusion is that the solar energy system must be designed for the type of application in which it is used. Misapplication usually will have an adverse affect on system performance.

SPOOL-FIRE: an IBM 370/195 code for the analysis of combined spray and pool burning of sodium

International Nuclear Information System (INIS)

Charak, I.; Person, L.W.

1976-01-01

A code for the computation of the pressure and temperatures within a containment building as a result of a sodium fire is described. The fire is assumed to occur in two distinct phases: a spray and a pool. The spray fire is conservatively assumed to occur instantaneously. The pool fire model used is the SOFIRE-II model developed by Atomics International. The code calculates all important temperatures, accounting for heat loss from the building to the environment, as well as leakage of the containment atmosphere under conditions of internal overpressure. The IBM CSMP methodology is used to solve the set of ordinary differential equations which model the system. The use of CSMP allows the user considerable flexibility in modifying the models employed

TAE+ 5.2 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.2 (DEC RISC ULTRIX VERSION)

Science.gov (United States)

TAE SUPPORT OFFICE

1994-01-01

programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides a means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System and the Open Software Foundation's Motif. The HP 9000 Series 700/800 version of TAE 5.2 requires Version 11 Release 5 of the X Window System. All other machine versions of TAE 5.2 require Version 11, Release 4 of the X Window System. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus was developed in 1989 and version 5.2 was released in 1993. TAE Plus 5.2 is available on media suitable for five different machine platforms: (1) IBM RS/6000 series workstations running AIX (.25 inch tape cartridge in UNIX tar format), (2) DEC RISC

Impact of ventricular assist device placement on longitudinal renal function in children with end-stage heart failure.

Science.gov (United States)

May, Lindsay J; Montez-Rath, Maria E; Yeh, Justin; Axelrod, David M; Chen, Sharon; Maeda, Katsuhide; Almond, Christopher S D; Rosenthal, David N; Hollander, Seth A; Sutherland, Scott M

2016-04-01

Although ventricular assist devices (VADs) restore hemodynamics in those with heart failure, reversibility of end-organ dysfunction with VAD support is not well characterized. Renal function often improves in adults after VAD placement, but this has not been comprehensively explored in children. Sixty-three children on VAD support were studied. Acute kidney injury (AKI) was defined by Kidney Disease: Improving Global Outcomes criteria. Estimated glomerular filtration rate (eGFR) was determined by the Schwartz method. Generalized linear mixed-effects models compared the pre-VAD and post-VAD eGFR for the cohort and sub-groups with and without pre-VAD renal dysfunction (pre-VAD eGFR renal dysfunction. AKI affected 60.3% (38 of 63), with similar rates in those with and without pre-existing renal dysfunction. Within the cohort, the nadir eGFR occurred 1 day post-operatively (62.9 ml/min/1.73 m(2); IQR, 51.2-88.9 ml/min/1.73 m(2); p renal dysfunction experienced the greatest improvement in the eGFR (β = 0.0051 vs β = 0.0013, p Renal dysfunction is prevalent in children with heart failure undergoing VAD placement. Although peri-operative AKI is common, renal function improves substantially in the first post-operative week and for months thereafter. This is particularly pronounced in those with pre-VAD renal impairment, suggesting that VADs may facilitate recovery and maintenance of kidney function in children with advanced heart failure. Copyright © 2016 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

January: IBM 7094 programme for the resolution of cell problems in planar, spherical and cylindrical geometry using the double Pn approximation

International Nuclear Information System (INIS)

Amouyal, A.; Tariel, H.

1966-01-01

Code name: January 1 st SCEA 011S. 2) Computer: IBM 7094; Programme system: Fortran II, 2 nd version. 3) Nature of the problem: resolution of cell problems with one space variable (planar, spherical and cylindrical geometries) and with one energy group, with isotropic sources in the double P n approximation (DP 1 and DP 3 approximation in planar and spherical geometries, DP 1 and DP 2 in cylindrical geometry). 4) Method used: the differential equations with limiting conditions are transformed into differential system with initial conditions which are integrated by a separate-step method. 5) Restrictions: number of physical media [fr

Effective Anti-miRNA Oligonucleotides Show High Releasing Rate of MicroRNA from RNA-Induced Silencing Complex.

Science.gov (United States)

Ariyoshi, Jumpei; Matsuyama, Yohei; Kobori, Akio; Murakami, Akira; Sugiyama, Hiroshi; Yamayoshi, Asako

2017-10-01

MicroRNAs (miRNAs) regulate gene expression by forming RNA-induced silencing complexes (RISCs) and have been considered as promising therapeutic targets. MiRNA is an essential component of RISC for the modulation of gene expression. Therefore, the release of miRNA from RISC is considered as an effective method for the inhibition of miRNA functions. In our previous study, we reported that anti-miRNA oligonucleotides (AMOs), which are composed of the 2'-O-methyl (2'-OMe) RNA, could induce the release of miRNA from RISC. However, the mechanisms underlying the miRNA-releasing effects of chemically modified AMOs, which are conventionally used as anti-cancer drugs, are still unclear. In this study, we investigated the relationship between the miRNA releasing rate from RISC and the inhibitory effect on RISC activity (IC 50 ) using conventional chemically modified AMOs. We demonstrated that the miRNA-releasing effects of AMOs are directly proportional to the IC 50 values, and AMOs, which have an ability to promote the release of miRNA from RISC, can effectively inhibit RISC activity in living cells.

Multiple uses for an old ibm-pc 486 in nuclear medicine using open source software

International Nuclear Information System (INIS)

Anselmi, C.E.; Anselmi, O.E.

2002-01-01

Multiple uses for an old ibm-pc 486 in nuclear medicine using open source software. Aim: To use a low budget platform to: 1 - send patient's images from processing workstation to the nuclear medicine information system; 2 - backup data files from acquisition in DICOM format in cd-rom; 3 - move data across different hospitals allowing remote processing and reading of studies. Both nuclear medicine systems in the two hospitals are Siemens Icon workstations. Material and methods: The computer used is an ibm-pc 486, which sells for about US dollar 70. The operating system installed is Red Hat Linux 6.2. The sending of the patient's images to the information system is performed through AppleTalk and Samba. The backup of acquisition files is performed by the communication from the workstation through DICOM to the Storage Class Provider (Office Dicom Toolkit) running in the 486, and the files are later burned on cd-rom. A similar configuration is present in another hospital, with minor differences in processor type. Data from any of the hospitals can be sent to the other one through the remote synchronization performed by Rsync. The connection between both Linux computers is encrypted through Secure Shell (open SSH). All software installed in the 486 was downloaded from the internet at no cost. No software was installed in the workstations. Results: The whole system is recognized transparently by the workstation's system as a local storage disk, such as the acquisition cameras or the other workstations. The transfer of images from the workstation to the information system or to a remote hospital is done the same way as copying data from the acquisition cameras in the vendor's software. When transferring large files across hospitals, the synchronization may take 1 to 3 minutes through broad band internet. The backup in DICOM format in cd-rom allows review of patient data in any computer equipped with a DICOM viewing software, as well as the re-processing of that

Discovery of Acupoints and Combinations with Potential to Treat Vascular Dementia: A Data Mining Analysis

Directory of Open Access Journals (Sweden)

Shuwei Feng

2015-01-01

Full Text Available The prevalence of vascular dementia (VaD is high among the elderly. Acupuncture, a popular therapeutic method in China, can improve memory, orientation, calculation, and self-managing ability in VaD patients. However, in clinical acupuncture and acupuncture research, the selection of acupoints to treat VaD remains challenging. This study aimed to discover acupoints and acupoint combinations with potential for VaD based on data mining. After database searching and screening for articles on clinical trials evaluating the effects of acupuncture on VaD, 238 acupuncture prescriptions were included for further analysis. Baihui (GV 20, Sishencong (EX-HN 1, Fengchi (GB 20, Shuigou (GV 26, and Shenting (GV 24 appeared most frequently in the modern literature and are potential acupoints for VaD. Combinations between Baihui (GV 20, Sishencong (EX-HN 1, Fengchi (GB 20, Shenting (GV 24, Shuigou (GV 26, and Zusanli (ST 36 were most frequent and represent potential combinations for VaD treatment. These results provide a reference for the selection and combination of acupoints to treat VaD in clinical acupuncture and acupuncture research.

Vad behöver eleverna undervisning i för att utveckla sitt skrivande? Förväntningsnormer och didaktiska beslut i svensklärares bedömningssamtal

Directory of Open Access Journals (Sweden)

Per Blomqvist

2016-04-01

Full Text Available I studien samtalar tre lärargrupper om elevers skrivande och skrivundervisning i ämnet svenska på gymnasiet. Det teoretiska perspektiv som läggs på dessa samtal är didaktiskt och inriktas på hur lärare formulerar och använder bedömningsinformation om elevers skrivande för beslut om skrivundervisningens innehåll. Resultatet visar att lärares bedömningar av elevers skrivande behandlar fler och delvis andra aspekter av skrivförmåga än vad deras didaktiska beslut sedan omfattar. De kvalitetsuppfattningar och förväntningsnormer som lärarna uttrycker i sina bedömningar av elevers skrivande inriktas huvudsakligen på texters kommunikativa kvaliteter, den stilistiska utformningen och textuppbyggnaden, följt av ämnesinnehåll och källanvändning. De didaktiska beslut som fattas utifrån bedömningen av elevers texter inriktas däremot i stort sett enbart på att eleverna behöver skrivundervisning i att disponera text och att använda källor. Detta gör att överensstämmelsen är låg mellan lärarnas beslut om skrivundervisningens inriktning och deras förväntningar på vad eleverna ska kunna. De didaktiska besluten omfattar i begränsad utsträckning den bedömningsinformation som lärarna själva har formulerat.Nyckelord: Skrivbedömning, kvalitetsuppfattningar, förväntningsnormer, didaktiska beslut, formativ bedömning, svenskämnets didaktik, svenska på gymnasietAbstractThis article presents an analysis of teacher group discussions about students’ writing in the subject of Swedish in upper secondary school. The study adopts a pedagogical perspective on these discussions and focuses on examining teachers’ expressed assessment criteria and relating them to their pedagogical decision-making. The results reveal that the teachers’ assessments of students’ writing focus on much more, and partly other, criteria than their pedagogical decisions. The quality standards that teachers express in the discussions about

Hf-Nd Isotopes in West Philippine Basin Basalts: Results from International Ocean Discovery Program (IODP) Site U1438 and Implications for the Early History of the Izu-Bonin-Mariana (IBM) Subduction System

Science.gov (United States)

Yogodzinski, G. M.; Hocking, B.; Bizimis, M.; Hickey-Vargas, R.; Ishizuka, O.; Bogus, K.; Arculus, R. J.

2015-12-01

Drilling at IODP Site U1438, located immediately west of Kyushu-Palau Ridge (KPR), the site of IBM subduction initiation, penetrated 1460 m of volcaniclastic sedimentary rock and 150 m of underlying basement. Biostratigraphic controls indicate a probable age for the oldest sedimentary rocks at around 55 Ma (51-64 Ma - Arculus et al., Nat Geosci in-press). This is close to the 48-52 Ma time period of IBM subduction initiation, based on studies in the forearc. There, the first products of volcanism are tholeiitic basalts termed FAB (forearc basalt), which are more depleted than average MORB and show subtle indicators of subduction geochemical enrichment (Reagan et al., 2010 - Geochem Geophy Geosy). Shipboard data indicate that Site U1438 basement basalts share many characteristics with FABs, including primitive major elements (high MgO/FeO*) and strongly depleted incompatible element patterns (Ti, Zr, Ti/V and Zr/Y below those of average MORB). Initial results thus indicate that FAB geochemistry may have been produced not only in the forearc, but also in backarc locations (west of the KPR) at the time of subduction initiation. Hf-Nd isotopes for Site 1438 basement basalts show a significant range of compositions from ɛNd of 7.0 to 9.5 and ɛHf of 14.5 to 19.8 (present-day values). The data define a well-correlated and steep array in Hf-Nd isotope space. Relatively radiogenic Hf compared to Nd indicates an Indian Ocean-type MORB source, but the dominant signature, with ɛHf >16.5, is more radiogenic than most Indian MORB. The pattern through time is from more-to-less radiogenic and more variable Hf-Nd isotopes within the basement section. This pattern culminates in basaltic andesite sills, which intrude the lower parts of the sedimentary section. The sills have the least radiogenic compositions measured so far (ɛNd ~6.6, ɛHf ~13.8), and are similar to those of boninites of the IBM forearc and modern IBM arc and reararc rocks. The pattern within the basement

Magnetic suspension of the rotor of a ventricular assist device of mixed flow type.

Science.gov (United States)

Horikawa, Oswaldo; de Andrade, Aron José Pazin; da Silva, Isaías; Bock, Eduardo Guy Perpetuo

2008-04-01

This work presents results of preliminary studies concerning application of magnetic bearing in a ventricular assist device (VAD) being developed by Dante Pazzanese Institute of Cardiology-IDPC (São Paulo, Brazil). The VAD-IDPC has a novel architecture that distinguishes from other known VADs. In this, the rotor has a conical geometry with spiral impellers, showing characteristics that are intermediate between a centrifugal VAD and an axial VAD. The effectiveness of this new type of blood pumping principle was showed by tests and by using it in heart surgery for external blood circulation. However, the developed VAD uses a combination of ball bearings and mechanical seals, limiting the life for some 10 h, making impossible its long-term use or its use as an implantable VAD. As a part of development of an implantable VAD, this work aims at the replacement of ball bearings by a magnetic bearing. The most important magnetic bearing principles are studied and the magnetic bearing developed by Escola Politécnica of São Paulo University (EPUSP-MB) is elected because of its very simple architecture. Besides presenting the principle of the EPUSP-MB, this work presents one possible alternative for applying the EPUSP-MB in the IDPC-VAD.

Outcomes of ventricular assist device implantation in children and young adults: the Melbourne experience.

Science.gov (United States)

Shi, William Y; Marasco, Silvana F; Saxena, Pankaj; d'Udekem, Yves; Yong, Matthew S; Mitnovetski, Sergei; Brizard, Christian P; McGiffin, David C; Weintraub, Robert G; Konstantinov, Igor E

2016-12-01

We evaluated our experience with ventricular assist device (VAD) implantation in children and young adults. A total of 64 patients underwent VAD implantation in two centres. The mean age was 15 ± 7.2 years. Thirty-five (55%) patients were under 18 years of age. Devices implanted included the Thoratec Paracorporeal in 30 (47%) patients, Berlin Heart EXCOR in 11 (17%) and VentrAssist in 14 (22%). The diagnosis was cardiomyopathy in 53, congenital heart disease in 11, and graft failure in four patients. There were 10 (16%) in-hospital deaths. Mortality was higher in patients <18 years of age (26% compared with 3.4% for those ≥18 years, P = 0.02). The use of extracorporeal membrane oxygenation prior to VAD implantation was associated with higher mortality (P = 0.006). Seventeen (27%) patients experienced stroke. Nine patients (14%) required change of VAD because of thrombosis. Transplantation was performed in 44 patients after a mean of 131 ± 141 days on VAD, 11 patients died without transplantation and three patients currently await transplantation. The VAD was explanted in six patients because of recovery. Overall survival from VAD implantation was 69% and 61% at 5 and 10 years, respectively. The 5-year post-transplant survival for those bridged with VAD support was 91% and was comparable with a cohort of patients who did not receive a pre-transplant VAD. Children requiring pre-transplant VAD support have a higher mortality and morbidity compared with young adults. Survival after heart transplantation those supported with VADs was similar to patients of similar age who did not require pre-transplant support. © 2015 Royal Australasian College of Surgeons.

Cost-Effectiveness of Ventricular Assist Device Destination Therapy for Advanced Heart Failure in Duchenne Muscular Dystrophy.

Science.gov (United States)

Magnetta, Defne A; Kang, JaHyun; Wearden, Peter D; Smith, Kenneth J; Feingold, Brian

2018-05-17

Destination ventricular assist device therapy (DT-VAD) is well accepted in select adults with medically refractory heart failure (HF) who are not transplant candidates; however, its use in younger patients with progressive diseases is unclear. We sought to evaluate the cost-effectiveness of DT-VAD in Duchenne muscular dystrophy (DMD) patients with advanced HF. We created a Markov-state transition model (5-year horizon) to compare survival, costs, and quality of life (QOL) between medical management and DT-VAD in DMD with advanced HF. Model input parameters were derived from the literature. We used sensitivity analyses to explore uncertainty around model assumptions. DT-VAD had higher costs ($435,602 vs. $125,696), survival (3.13 vs. 0.60 years), and quality-adjusted survival (1.99 vs. 0.26 years) than medical management. The incremental cost-effectiveness ratio (ICER) for DT-VAD was $179,086 per quality-adjusted life year (QALY). In sensitivity analyses that were widely varied to account for uncertainty in model assumptions, the DT-VAD strategy generally remained more costly and effective than medical management. Only when VAD implantation costs were <$113,142 did the DT-VAD strategy fall below the $100,000/QALY willingness-to-pay threshold commonly considered to be "cost-effective." In this exploratory analysis, DT-VAD for patients with DMD and advanced HF exceeded societal expectations for cost-effectiveness but had an ICER similar to the accepted practice of DT-VAD in adult HF patients. While more experience and research in this population is needed, our analysis suggests that DT-VAD for advanced HF in DMD should not be dismissed solely based on cost.

FASTRAN II - FATIGUE CRACK GROWTH STRUCTURAL ANALYSIS (IBM PC VERSION)

Science.gov (United States)

Newman, J. C.

1994-01-01

loads may be either tensile or compressive. Several standardized aircraft flight-load histories, such as TWIST, Mini-TWIST, FALSTAFF, Inverted FALSTAFF, Felix and Gaussian, are included as options. FASTRAN II also includes two other methods that will help the user input spectrum load histories. The two methods are: (1) a list of stress points, and (2) a flight-by-flight history of stress points. Examples are provided in the user manual. Developed as a research program, FASTRAN II has successfully predicted crack growth in many metallic materials under various aircraft spectrum loading. A computer program DKEFF which is a part of the FASTRAN II package was also developed to analyze crack growth rate data from laboratory specimens to obtain the effective stress-intensity factor against crack growth rate relations used in FASTRAN II. FASTRAN II is written in standard FORTRAN 77. It has been successfully compiled and implemented on Sun4 series computers running SunOS and on IBM PC compatibles running MS-DOS using the Lahey F77L FORTRAN compiler. Sample input and output data are included with the FASTRAN II package. The UNIX version requires 660K of RAM for execution. The standard distribution medium for the UNIX version (LAR-14865) is a .25 inch streaming magnetic tape cartridge in UNIX tar format. It is also available on a 3.5 inch diskette in UNIX tar format. The standard distribution medium for the MS-DOS version (LAR-14944) is a 5.25 inch 360K MS-DOS format diskette. The contents of the diskette are compressed using the PKWARE archiving tools. The utility to unarchive the files, PKUNZIP.EXE, is included. The program was developed in 1984 and revised in 1992. Sun4 and SunOS are trademarks of Sun Microsystems, Inc. IBM PC is a trademark of International Business Machines Corp. MS-DOS is a trademark of Microsoft, Inc. F77L is a trademark of the Lahey Computer Systems, Inc. UNIX is a registered trademark of AT&T Bell Laboratories. PKWARE and PKUNZIP are trademarks of PKWare

Geochemistry of Volcanic Rocks from International Ocean Discovery Program (IODP) Site 1438, Amami Sankaku Basin: Implications for Izu-Bonin-Mariana (IBM) Arc Initiation

Science.gov (United States)

Hickey-Vargas, R.; Ishizuka, O.; Yogodzinski, G. M.; Bizimis, M.; Savov, I. P.; McCarthy, A. J.; Arculus, R. J.; Bogus, K.

2015-12-01

IODP Expedition 351 drilled 150 m of volcanic basement overlain by 1461 m of sedimentary material at Site 1438 in the Amami Sankaku basin, just west of the Kyushu Palau Ridge, the locus of IBM arc initiation. Age interpretations based on biostratigraphy (Arculus et al., Nat. Geosci., in-press) determined that the age of the basement section is between 64 and 51 Ma, encompassing the age of the earliest volcanic products of the IBM arc. The Site 1438 volcanic basement consists of multiple flows of aphyric microcrystalline to finely crystalline basalts containing plagioclase and clinopyroxene with rare olivine pseudomorphs. New XRF major and ICPMS trace element data confirm findings of shipboard analysis that the basalts are moderately differentiated (6-14 % MgO; Mg# = 51-83; 73-490 ppm Cr and 58-350 ppm Ni) with downcore variations related to flow units. Ti/V and Ti/Sc ratios are 16-27 and 75-152, respectively, with lowest values at the base of the core. One prominent characteristic of the basalts is their depletion of immobile highly incompatible elements compared with MORB. Basalts have MORB-normalized La/Nd of 0.5 to 0.9, and most have Th/La 3 and primitive mantle normalized La/Yb > 1. Our results suggest that mantle melting at the onset of subduction involved exceptionally depleted sources. Enrichment over time may be related to increasing subduction inputs and/or other processes, such as entrainment of fertile asthenosphere during extension of the overriding plate.

Automated IBM PC/XT/AT based measurement and control system for the DRON-3M X-ray diffractometer

International Nuclear Information System (INIS)

Tulaev, A.B.

1989-01-01

An automated IBM PC/XT/AT based measurement and control system for the DRON-3M X-ray diffractometer is decribed. The system permits carrying out of real time diffractometer control automatic X-spectra measurement and data acquisition, as well as experimental information computing and representation. The electronic of the system consists of a CAMAC crate with analog and power modules, and a control and measurement organization module, performed as a single bord in the standard of PC electronics. The system provides X-spectra acquisition with volume up to 4K in the angle range from 100 to 160 degrees with a resolution of 0.01 degree, a dead time less than 1mks and an exposition time from tenths of a second to dozens of minutes. 3 refs.; 5 figs

Intelligent Bioreactor Management Information System (IBM-IS) for Mitigation of Greenhouse Gas Emissions

Energy Technology Data Exchange (ETDEWEB)

Paul Imhoff; Ramin Yazdani; Don Augenstein; Harold Bentley; Pei Chiu

2010-04-30

Methane is an important contributor to global warming with a total climate forcing estimated to be close to 20% that of carbon dioxide (CO2) over the past two decades. The largest anthropogenic source of methane in the US is 'conventional' landfills, which account for over 30% of anthropogenic emissions. While controlling greenhouse gas emissions must necessarily focus on large CO2 sources, attention to reducing CH4 emissions from landfills can result in significant reductions in greenhouse gas emissions at low cost. For example, the use of 'controlled' or bioreactor landfilling has been estimated to reduce annual US greenhouse emissions by about 15-30 million tons of CO2 carbon (equivalent) at costs between $3-13/ton carbon. In this project we developed or advanced new management approaches, landfill designs, and landfill operating procedures for bioreactor landfills. These advances are needed to address lingering concerns about bioreactor landfills (e.g., efficient collection of increased CH4 generation) in the waste management industry, concerns that hamper bioreactor implementation and the consequent reductions in CH4 emissions. Collectively, the advances described in this report should result in better control of bioreactor landfills and reductions in CH4 emissions. Several advances are important components of an Intelligent Bioreactor Management Information System (IBM-IS).

Sociālo tīklu izmantošana pusaudžu vecumā un to vadīšanas iespējas interešu izglītībā

OpenAIRE

Biezais, Artūrs

2015-01-01

Pētījuma nosaukums ir „Sociālo tīklu izmantošana pusaudžu vecumā un to vadīšanas iespējas interešu izglītībā”. Dažādos pētījumos ir pierādīts, ka tieši pusaudžu vecumposms ir tas, kurā bērni visvairāk laika pavada sociālajos tīklos. Viņi tiem piekļūst ar datoru, ar viedtālruņu un planšetdatoru palīdzību. Neskatoties uz to, ka bērni sociālos tīklus ļoti aktīvi izmanto ārpus skolas, viņi tos izmanto arī skolā un pat mācību stundās. Tā ir mūsdienu realitāte, kas visnotaļ, atkarībā no sociālo med...

An Estimate of Attributable Cases of Alzheimer Disease and Vascular Dementia due to Modifiable Risk Factors: The Impact of Primary Prevention in Europe and in Italy

Directory of Open Access Journals (Sweden)

Flavia Mayer

2018-02-01

Full Text Available Background: Up to 53.7% of all cases of dementia are assumed to be due to Alzheimer disease (AD, while 15.8% are considered to be due to vascular dementia (VaD. In Europe, about 3 million cases of AD could be due to 7 potentially modifiable risk factors: diabetes, midlife hypertension and/or obesity, physical inactivity, depression, smoking, and low educational level. Aims: To estimate the number of VaD cases in Europe and the number of AD and VaD cases in Italy attributable to these 7 potentially modifiable risk factors. Methods: Assuming the nonindependence of the 7 risk factors, the adjusted combined population attributable risk (PAR was estimated for AD and VaD. Results: In Europe, adjusted combined PAR was 31.4% for AD and 37.8% for VaD. The total number of attributable cases was 3,033,000 for AD and 873,000 for VaD. In Italy, assuming a 20% reduction of the prevalence of each risk factor, adjusted combined PAR decreased from 45.2 to 38.9% for AD and from 53.1 to 46.6% for VaD, implying a 6.4 and 6.5% reduction in the prevalence of AD and VaD, respectively. Conclusion: A relevant reduction of AD and VaD cases in Europe and Italy could be obtained through primary prevention.

An Estimate of Attributable Cases of Alzheimer Disease and Vascular Dementia due to Modifiable Risk Factors: The Impact of Primary Prevention in Europe and in Italy.

Science.gov (United States)

Mayer, Flavia; Di Pucchio, Alessandra; Lacorte, Eleonora; Bacigalupo, Ilaria; Marzolini, Fabrizio; Ferrante, Gianluigi; Minardi, Valentina; Masocco, Maria; Canevelli, Marco; Di Fiandra, Teresa; Vanacore, Nicola

2018-01-01

Up to 53.7% of all cases of dementia are assumed to be due to Alzheimer disease (AD), while 15.8% are considered to be due to vascular dementia (VaD). In Europe, about 3 million cases of AD could be due to 7 potentially modifiable risk factors: diabetes, midlife hypertension and/or obesity, physical inactivity, depression, smoking, and low educational level. To estimate the number of VaD cases in Europe and the number of AD and VaD cases in Italy attributable to these 7 potentially modifiable risk factors. Assuming the nonindependence of the 7 risk factors, the adjusted combined population attributable risk (PAR) was estimated for AD and VaD. In Europe, adjusted combined PAR was 31.4% for AD and 37.8% for VaD. The total number of attributable cases was 3,033,000 for AD and 873,000 for VaD. In Italy, assuming a 20% reduction of the prevalence of each risk factor, adjusted combined PAR decreased from 45.2 to 38.9% for AD and from 53.1 to 46.6% for VaD, implying a 6.4 and 6.5% reduction in the prevalence of AD and VaD, respectively. A relevant reduction of AD and VaD cases in Europe and Italy could be obtained through primary prevention.

How the factoid of wind turbines causing 'vibroacoustic disease' came to be 'irrefutably demonstrated'.

Science.gov (United States)

Chapman, Simon; St George, Alexis

2013-06-01

In recent years, claims have proliferated in cyberspace that wind turbines cause a large variety of symptoms and diseases. One of these, "vibroacoustic disease" (VAD) is frequently mentioned. The aim of this study is to examine the quality of the evidence on how VAD came to be associated with wind turbine exposure by wind farm opponents. Searches of the web (Google advanced) and major research databases for papers on VAD and wind turbines. Self-citation analysis of research papers on VAD. Google returned 24,700 hits for VAD and wind turbines. Thirty-five research papers on VAD were found, none reporting any association between VAD and wind turbines. Of the 35 papers, 34 had a first author from a single Portuguese research group. Seventy-four per cent of citations to these papers were self-citations by the group. Median self-citation rates in science are around 7%. Two unpublished case reports presented at conferences were found asserting that VAD was "irrefutably demonstrated" to be caused by wind turbines. The quality of these reports was abject. VAD has received virtually no scientific recognition beyond the group who coined and promoted the concept. There is no evidence of even rudimentary quality that vibroacoustic disease is associated with or caused by wind turbines. The claim that wind turbines cause VAD is a factoid that has gone 'viral' in cyberspace and may be contributing to nocebo effects among those living near turbines. © 2013 The Authors. ANZJPH © 2013 Public Health Association of Australia.

Survivability enhancement study for C/sup 3/I/BM (communications, command, control and intelligence/battle management) ground segments: Final report

Energy Technology Data Exchange (ETDEWEB)

1986-10-30

This study involves a concept developed by the Fairchild Space Company which is directly applicable to the Strategic Defense Initiative (SDI) Program as well as other national security programs requiring reliable, secure and survivable telecommunications systems. The overall objective of this study program was to determine the feasibility of combining and integrating long-lived, compact, autonomous isotope power sources with fiber optic and other types of ground segments of the SDI communications, command, control and intelligence/battle management (C/sup 3/I/BM) system in order to significantly enhance the survivability of those critical systems, especially against the potential threats of electromagnetic pulse(s) (EMP) resulting from high altitude nuclear weapon explosion(s). 28 figs., 2 tabs.

Post-transplant outcomes in pediatric ventricular assist device patients: A PediMACS-Pediatric Heart Transplant Study linkage analysis.

Science.gov (United States)

Sutcliffe, David L; Pruitt, Elizabeth; Cantor, Ryan S; Godown, Justin; Lane, John; Turrentine, Mark W; Law, Sabrina P; Lantz, Jodie L; Kirklin, James K; Bernstein, Daniel; Blume, Elizabeth D

2017-12-13

Pediatric ventricular assist device (VAD) support as bridge to transplant has improved waitlist survival, but the effects of pre-implant status and VAD-related events on post-transplant outcomes have not been assessed. This study is a linkage analysis between the PediMACS and Pediatric Heart Transplant Study databases to determine the effects of VAD course on post-transplant outcomes. Database linkage between October 1, 2012 and December 31, 2015 identified 147 transplanted VAD patients, the primary study group. The comparison cohort was composed of 630 PHTS patients without pre-transplant VAD support. The primary outcome was post-transplant survival, with secondary outcomes of post-transplant length of stay, freedom from infection and freedom from rejection. At implant, the VAD cohort was INTERMACS Profile 1 in 33 (23%), Profile 2 in 89 (63%) and Profile 3 in 14 (10%) patients. The VAD cohort was older, larger, and less likely to have congenital heart disease (p < 0.0001). However, they had greater requirements for inotrope and ventilator support and increased liver and renal dysfunction (p < 0.0001), both of which normalized at transplant after device support. Importantly, there were no differences in 1-year post-transplant survival (96% vs 93%, p = 0.3), freedom from infection (81% vs 79%, p = 0.9) or freedom from rejection (71% vs 74%, p = 0.87) between cohorts. Pediatric VAD patients have post-transplant outcomes equal to that of medically supported patients, despite greater pre-implant illness severity. Post-transplant survival, hospital length of stay, infection and rejection were not affected by patient acuity at VAD implantation or VAD-related complications. Therefore, VAD as bridge to transplant mitigates severity of illness in children. Copyright © 2017 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

Numerical analysis of resonances induced by s wave neutrons in transmission time-of-flight experiments with a computer IBM 7094 II

International Nuclear Information System (INIS)

Corge, Ch.

1969-01-01

Numerical analysis of transmission resonances induced by s wave neutrons in time-of-flight experiments can be achieved in a fairly automatic way on an IBM 7094/II computer. The involved computations are carried out following a four step scheme: 1 - experimental raw data are processed to obtain the resonant transmissions, 2 - values of experimental quantities for each resonance are derived from the above transmissions, 3 - resonance parameters are determined using a least square method to solve the over determined system obtained by equalling theoretical functions to the correspondent experimental values. Four analysis methods are gathered in the same code, 4 - graphical control of the results is performed. (author) [fr

Procedures to analyse γ-ray spectra obtained from the ORTEC or nuclear data ND-680 system by ORTEC's analysis software packages incorporated into a separate IBM-PC computer

International Nuclear Information System (INIS)

Zhang Xiu Zhen.

1990-01-01

A detailed description is presented for processing γ-spectra produced by means of Ortec or Nuclear Data spectrometry systems on an off-line IBM-PC. The ORTEC analysis software packages were transferred to and implemented on the PC A/T, and the different spectra were recorded on discs and subsequently brought into the format required by the program for the calculation of photo peak areas. (author)

Case Study: IBM Watson Analytics Cloud Platform as Analytics-as-a-Service System for Heart Failure Early Detection

Directory of Open Access Journals (Sweden)

Gabriele Guidi

2016-07-01

Full Text Available In the recent years the progress in technology and the increasing availability of fast connections have produced a migration of functionalities in Information Technologies services, from static servers to distributed technologies. This article describes the main tools available on the market to perform Analytics as a Service (AaaS using a cloud platform. It is also described a use case of IBM Watson Analytics, a cloud system for data analytics, applied to the following research scope: detecting the presence or absence of Heart Failure disease using nothing more than the electrocardiographic signal, in particular through the analysis of Heart Rate Variability. The obtained results are comparable with those coming from the literature, in terms of accuracy and predictive power. Advantages and drawbacks of cloud versus static approaches are discussed in the last sections.

Prevalence and factors associated with vitamin A deficiency in children and adolescents

Directory of Open Access Journals (Sweden)

Rita de Cássia Ribeiro-Silva

2014-09-01

Full Text Available Objective: To identify the prevalence and factors associated with vitamin A deficiency (VAD in children and adolescents. Methods: This was a cross-sectional study involving 546 schoolchildren, aged between 7 and 14 years, of both genders, enrolled in public elementary schools. Blood was collected for measurement of serum retinol. The retinol concentration in the samples was determined by high performance liquid chromatography (HPLC. Data were collected on anthropometrics, dietary, demographic, and socioeconomic factors. Polytomous logistic regression was used to evaluate the associations of interest. Results: Approximately 27.5% of the students had retinol values < 30 μg/dL. The multivariate analysis showed, after the appropriate adjustments, a positive and statistically significant association of moderate/severe VAD (OR = 2.19; 95% CI 1.17 to 4.10 and marginal VAD (OR = 2.34; 95% CI 1.47 to 3.73 with age < 10 years. There was also association of VAD moderate/severe (OR = 2.01; 95% CI 1.01 to 5.05 and borderline VAD (OR = 2.14; 95% CI: 1.08 to 4.21 with the anthropometric status of underweight. Lower intake of retinol was detected among those with severe VAD. Conclusion: VAD is a health concern among children and adolescents. Lower weight and younger schoolchildren had greater vulnerability to VAD.

High pulmonary vascular resistance in addition to low right ventricular stroke work index effectively predicts biventricular assist device requirement.

Science.gov (United States)

Imamura, Teruhiko; Kinugawa, Koichiro; Kinoshita, Osamu; Nawata, Kan; Ono, Minoru

2016-03-01

Although the right ventricular stroke work index (RVSWI) is a good index for RV function, a low RVSWI is not necessarily an indicator for the need for a right ventricular assist device at the time of left VAD implantation. We here aimed to determine a more precise indicator for the need for a biventricular assist device (BiVAD). In total, 116 patients (mean age, 38 ± 14 years), who underwent hemodynamic assessments preoperatively including 12 BiVAD patients, and had been followed at our institute from 2003 to 2015, were included. Multivariate logistic regression analysis indicated that RVSWI and pulmonary vascular resistance (PVR) were independent predictors of BiVAD requirement (P 5 g/m, PVR 5, PVR > 3.7), (3) RV failure (RVSWI 3.7), and examined. Most of the patients in Group 4 (75 %), with acutely depressed hemodynamics and inflammatory responses in the myocardium, required BiVAD. Overall, patients with BiVAD had a worse survival rate as compared with those with LVAD alone. In conclusion, high PVR in addition to low RVSWI effectively predicts BiVAD requirement.

Classic Multi-Configuration-Dirac-Fock and Hartree-Fock-Relativistic methods integrated into a program package for the RAL-IBM mainframe with automatic comparative output

International Nuclear Information System (INIS)

Cowan, R.D.; Grant, I.P.; Fawcett, B.C.; Rose, S.J.

1985-11-01

A Multi-Configuration-Dirac-Fock (MCDF) computer program is adapted to interface with the Hartree-Fock-Relativistic (HFR) program for the RAL IBM mainframe computer. The two codes are integrated into a package which includes the Zeeman Laboratory Slater parameter optimisation routines as well as new RAL routines to further process the HFR and MCDF output. A description of the adaptions to MCDF and new output extensions is included in this report, and details are given regarding HFR FORTRAN subroutines, and lists of Job Control Language (JCL) files for the complete package. (author)

Measurement stand for diagnosis of semiconductor detectors based on IBM PC/XT computer (4-way spectrometric analysis of pulses)

International Nuclear Information System (INIS)

Gruszecki, M.

1990-01-01

The technical assumptions and partial realization of our technological stand for quality inspection of semiconductor detectors for ionizing radiation manufactured in the INP in Cracow are described. To increase the efficiency of the measurements simultaneous checking of 4 semiconductor chips or finished products is suggested. In order to justify this measurement technique a review of possible variants of the measurement apparatus is presented for the systems consisting of home made units. Comparative parameters for the component modules and for complete measuring systems are given. The construction and operation of data acquisition system based on IBM PC/XT are described. The system ensures simultaneous registration of pulses obtained from 4 detectors with maximal rate of up to 500 x 10 3 pulses/s. 42 refs., 6 figs., 3 tabs. (author)

Analysis of Defenses Against Code Reuse Attacks on Modern and New Architectures

Science.gov (United States)

2015-09-01

Hardware Architecture 55 5.1 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5.2 RISC -V Extensions...56 5.3 RISC -V Tag Policies . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 5.3.1 Basic Return Pointer Policy...60 5.4 RISC -V Policy Test Framework . . . . . . . . . . . . . . . . . . . . . 60 6 Compiler Support 63 6.1 LLVM

10 CFR 50.69 - Risk-informed categorization and treatment of structures, systems and components for nuclear...

Science.gov (United States)

2010-01-01

..., systems and components for nuclear power reactors. (a) Definitions. Risk-Informed Safety Class (RISC)-1... functions. Risk-Informed Safety Class (RISC)-2 structures, systems and components (SSCs) means nonsafety-related SSCs that perform safety significant functions. Risk-Informed Safety Class (RISC)-3 structures...

Vitamin A deficiency impairs adaptive B and T cell responses to a prototype monovalent attenuated human rotavirus vaccine and virulent human rotavirus challenge in a gnotobiotic piglet model.

Directory of Open Access Journals (Sweden)

Kuldeep S Chattha

Full Text Available Rotaviruses (RV are a major cause of gastroenteritis in children. Widespread vitamin A deficiency is associated with reduced efficacy of vaccines and higher incidence of diarrheal infections in children in developing countries. We established a vitamin A deficient (VAD gnotobiotic piglet model that mimics subclinical vitamin A deficiency in children to study its effects on an oral human rotavirus (HRV vaccine and virulent HRV challenge. Piglets derived from VAD and vitamin A sufficient (VAS sows were orally vaccinated with attenuated HRV or mock, with/without supplemental vitamin A and challenged with virulent HRV. Unvaccinated VAD control piglets had significantly lower hepatic vitamin A, higher severity and duration of diarrhea and HRV fecal shedding post-challenge as compared to VAS control pigs. Reduced protection coincided with significantly higher innate (IFNα cytokine and CD8 T cell frequencies in the blood and intestinal tissues, higher pro-inflammatory (IL12 and 2-3 fold lower anti-inflammatory (IL10 cytokines, in VAD compared to VAS control pigs. Vaccinated VAD pigs had higher diarrhea severity scores compared to vaccinated VAS pigs, which coincided with lower serum IgA HRV antibody titers and significantly lower intestinal IgA antibody secreting cells post-challenge in the former groups suggesting lower anamnestic responses. A trend for higher serum HRV IgG antibodies was observed in VAD vs VAS vaccinated groups post-challenge. The vaccinated VAD (non-vitamin A supplemented pigs had significantly higher serum IL12 (PID2 and IFNγ (PID6 compared to vaccinated VAS groups suggesting higher Th1 responses in VAD conditions. Furthermore, regulatory T-cell responses were compromised in VAD pigs. Supplemental vitamin A in VAD pigs did not fully restore the dysregulated immune responses to AttHRV vaccine or moderate virulent HRV diarrhea. Our findings suggest that that VAD in children in developing countries may partially contribute to more

The 5'-end heterogeneity of adenovirus virus-associated RNAI contributes to the asymmetric guide strand incorporation into the RNA-induced silencing complex.

Science.gov (United States)

Xu, Ning; Gkountela, Sofia; Saeed, Khalid; Akusjärvi, Göran

2009-11-01

Human Adenovirus type 5 encodes two short RNA polymerase III transcripts, the virus-associated (VA) RNAI and VA RNAII, which can adopt stable hairpin structures that resemble micro-RNA precursors. The terminal stems of the VA RNAs are processed into small RNAs (mivaRNAs) that are incorporated into RISC. It has been reported that VA RNAI has two transcription initiation sites, which produce two VA RNAI species; a major species, VA RNAI(G), which accounts for 75% of the VA RNAI pool, and a minor species, VA RNAI(A), which initiates transcription three nucleotides upstream compared to VA RNAI(G). We show that this 5'-heterogeneity results in a dramatic difference in RISC assembly. Thus, both VA RNAI(G) and VA RNAI(A) are processed by Dicer at the same position in the terminal stem generating the same 3'-strand mivaRNA. This mivaRNA is incorporated into RISC with 200-fold higher efficiency compared to the 5'-strand of mivaRNAI. Of the small number of 5'-strands used in RISC assembly only VA RNAI(A) generated active RISC complexes. We also show that the 3'-strand of mivaRNAI, although being the preferred substrate for RISC assembly, generates unstable RISC complexes with a low in vitro cleavage activity, only around 2% compared to RISC assembled on the VA RNAI(A) 5'-strand.

Herbal Medicine for the Treatment of Vascular Dementia: An Overview of Scientific Evidence

Directory of Open Access Journals (Sweden)

Dennis Chang

2016-01-01

Full Text Available Dementia is a leading cause of mental and physical disability. Vascular dementia (VaD is the second most common cause of dementia after Alzheimer’s disease (AD constituting 10–15% of the dementia population. Currently there are no approved pharmaceutical options for VaD and the conventional anti-AD therapies provide only modest, short-term relief of symptoms associated with VaD. Herbal medicines have been used for the management of dementia-like symptoms for centuries and may provide viable therapies for VaD due to their multicomponent and multitarget approach. This review is designed to provide an updated overview on the current status of herbal medicine research, with an emphasis on Chinese herbal medicine, for the treatment of VaD or dementia. A case study is also provided to demonstrate the development process of a novel standardized complex herbal formulation for VaD. The article reveals some preliminary evidence to support the use of single and complex herbal preparations for VaD and dementia. Multiple issues in relation to clinical and preclinical research have been identified and future research directions are discussed.

The pharmacotherapy implications of ventricular assist device in the patient with end-stage heart failure.

Science.gov (United States)

Von Ruden, Serena A S; Murray, Margaret A; Grice, Jennifer L; Proebstle, Amy K; Kopacek, Karen J

2012-04-01

Advances in mechanical circulatory support, such as the use of ventricular assist devices (VADs), have become a means for prolonging survival in end-stage heart failure (HF). VADs decrease the symptoms of HF and improve quality of life by replacing some of the work of a failing heart. They unload the ventricle to provide improved cardiac output and end-organ perfusion, resulting in improvement in cardiorenal syndromes and New York Heart Association functional class rating. VADs are currently used asa bridge to heart transplantation, a bridge to recovery of cardiac function, or as destination therapy. Complications of VAD include bleeding, infections, arrhythmias, multiple organ failure, right ventricular failure, and neurological dysfunction. Patients with VAD have unique pharmacotherapeutic requirements in terms of anticoagulation, appropriate antibiotic selection, and continuation of HF medications. Pharmacists in acute care and community settings are well prepared to care for the patient with VAD. These patients require thorough counseling and follow-up with regard to prevention and treatment of infections, appropriate levels of anticoagulation, and maintenance of fluid balance. A basic understanding of this unique therapy can assist pharmacists in attending to the needs of patients with VAD.

Electron microscope studies

International Nuclear Information System (INIS)

Crewe, A.V.; Kapp, O.H.

1990-01-01

Our laboratory has made significant progress this year in devising improved electron-optical systems, in studying invertebrate hemoglobins with the STEM, and in achieving a workable sub-angstrom STEM. Our goal in electron optics is to improve resolution by producing spherical and chromatic aberration coefficients with signs opposite those of magnetic lenses. We have progressed toward this goal through calculations that explore the addition of electrodes to electron mirrors to reduce these two geometric aberrations and by devising a beam separation system that won't introduce asymmetrical aberrations. Some promising new designs of magnetic lenses for SEM applications have also been investigated. We have continued our exploration of the quaternary structure of the invertebrate hemoglobins and are now among the top laboratories in this area of expertise. In addition, we have overcome many of our electronic difficulties on the sub-angstrom STEM and have made significant progress toward achieving an operational system. The addition of an IBM RISC-6000 workstation to our lab has significantly increased our image processing capabilities

JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation

Directory of Open Access Journals (Sweden)

Camilla A. Richmond

2018-01-01

Full Text Available The intestinal epithelium serves as an essential barrier to the outside world and is maintained by functionally distinct populations of rapidly cycling intestinal stem cells (CBC ISCs and slowly cycling, reserve ISCs (r-ISCs. Because disruptions in the epithelial barrier can result from pathological activation of the immune system, we sought to investigate the impact of inflammation on ISC behavior during the regenerative response. In a murine model of αCD3 antibody-induced small-intestinal inflammation, r-ISCs proved highly resistant to injury, while CBC ISCs underwent apoptosis. Moreover, r-ISCs were induced to proliferate and functionally contribute to intestinal regeneration. Further analysis revealed that the inflammatory cytokines interferon gamma and tumor necrosis factor alpha led to r-ISC activation in enteroid culture, which could be blocked by the JAK/STAT inhibitor, tofacitinib. These results highlight an important role for r-ISCs in response to acute intestinal inflammation and show that JAK/STAT-1 signaling is required for the r-ISC regenerative response.

A nested mechanistic sub-study into the effect of tranexamic acid versus placebo on intracranial haemorrhage and cerebral ischaemia in isolated traumatic brain injury: study protocol for a randomised controlled trial (CRASH-3 Trial Intracranial Bleeding Mechanistic Sub-Study [CRASH-3 IBMS]).

Science.gov (United States)

Mahmood, Abda; Roberts, Ian; Shakur, Haleema

2017-07-17

Tranexamic acid prevents blood clots from breaking down and reduces bleeding. However, it is uncertain whether tranexamic acid is effective in traumatic brain injury. The CRASH-3 trial is a randomised controlled trial that will examine the effect of tranexamic acid (versus placebo) on death and disability in 13,000 patients with traumatic brain injury. The CRASH-3 trial hypothesizes that tranexamic acid will reduce intracranial haemorrhage, which will reduce the risk of death. Although it is possible that tranexamic acid will reduce intracranial bleeding, there is also a potential for harm. In particular, tranexamic acid may increase the risk of cerebral thrombosis and ischaemia. The protocol detailed here is for a mechanistic sub-study nested within the CRASH-3 trial. This mechanistic sub-study aims to examine the effect of tranexamic acid (versus placebo) on intracranial bleeding and cerebral ischaemia. The CRASH-3 Intracranial Bleeding Mechanistic Sub-Study (CRASH-3 IBMS) is nested within a prospective, double-blind, multi-centre, parallel-arm randomised trial called the CRASH-3 trial. The CRASH-3 IBMS will be conducted in a cohort of approximately 1000 isolated traumatic brain injury patients enrolled in the CRASH-3 trial. In the CRASH-3 IBMS, brain scans acquired before and after randomisation are examined, using validated methods, for evidence of intracranial bleeding and cerebral ischaemia. The primary outcome is the total volume of intracranial bleeding measured on computed tomography after randomisation, adjusting for baseline bleeding volume. Secondary outcomes include progression of intracranial haemorrhage (from pre- to post-randomisation scans), new intracranial haemorrhage (seen on post- but not pre-randomisation scans), intracranial haemorrhage following neurosurgery, and new focal ischaemic lesions (seen on post-but not pre-randomisation scans). A linear regression model will examine whether receipt of the trial treatment can predict haemorrhage

Integrating Biodiversity into Biosphere-Atmosphere Interactions Using Individual-Based Models (IBM)

Science.gov (United States)

Wang, B.; Shugart, H. H., Jr.; Lerdau, M.

2017-12-01

A key component regulating complex, nonlinear, and dynamic biosphere-atmosphere interactions is the inherent diversity of biological systems. The model frameworks currently widely used, i.e., Plant Functional Type models) do not even begin to capture the metabolic and taxonomic diversity found in many terrestrial systems. We propose that a transition from PFT-based to individual-based modeling approaches (hereafter referred to as IBM) is essential for integrating biodiversity into research on biosphere-atmosphere interactions. The proposal emerges from our studying the interactions of forests with atmospheric processes in the context of climate change using an individual-based forest volatile organic compounds model, UVAFME-VOC. This individual-based model can explicitly simulate VOC emissions based on an explicit modelling of forest dynamics by computing the growth, death, and regeneration of each individual tree of different species and their competition for light, moisture, and nutrient, from which system-level VOC emissions are simulated by explicitly computing and summing up each individual's emissions. We found that elevated O3 significantly altered the forest dynamics by favoring species that are O3-resistant, which, meanwhile, are producers of isoprene. Such compositional changes, on the one hand, resulted in unsuppressed forest productivity and carbon stock because of the compensation by O3-resistant species. On the other hand, with more isoprene produced arising from increased producers, a possible positive feedback loop between tropospheric O3 and forest thereby emerged. We also found that climate warming will not always stimulate isoprene emissions because warming simultaneously reduces isoprene emissions by causing a decline in the abundance of isoprene-emitting species. These results suggest that species diversity is of great significance and that individual-based modelling strategies should be applied in studying biosphere-atmosphere interactions.

Identifying hotspots of coastal risk and evaluating DRR measures: results from the RISC-KIT project.

Science.gov (United States)

Van Dongeren, A.; Ciavola, P.; Viavattene, C.; Dekleermaeker, S.; Martinez, G.; Ferreira, O.; Costa, C.

2016-02-01

High-impact storm events have demonstrated the vulnerability of coastal zones in Europe and beyond. These impacts are likely to increase due to predicted climate change and ongoing coastal development. In order to reduce impacts, disaster risk reduction (DRR) measures need to be taken, which prevent or mitigate the effects of storm events. To drive the DRR agenda, the UNISDR formulated the Sendai Framework for Action, and the EU has issued the Floods Directive. However, neither is specific about the methods to be used to develop actionable DRR measures in the coastal zone. Therefore, there is a need to develop methods, tools and approaches which make it possible to: identify and prioritize the coastal zones which are most at risk through a Coastal Risk Assessment Framework, evaluate the effectiveness of DRR options for these coastal areas, using an Early Warning/Decision Support System, which can be used both in the planning and event-phase. This paper gives an overview of the products and results obtained in the FP7-funded project RISC-KIT, which aims to develop and apply a set of tools with which highly-vulnerable coastal areas (so-called "hotspots") can be identified. The identification is done using the Coastal Risk Assessment Framework, or CRAF, which computes the intensity from multi-hazards, the exposure and the vulnerability, all components of risk, including network and cascading effects. Based on this analysis hot spots of risk which warrant coastal protection investments are selected. For these hotspot areas, high-resolution Early Warning and Decision Support Tools are developed with which it is possible to compute in detail the effectiveness of Disaster Risk Reduction measures in storm event scenarios, which helps decide which measures to implement in the planning phase. The same systems, but now driven with real time data, can also be used for early warning systems. All tools are tested on eleven case study areas, at least one on each EU Regional Sea

Graph theoretical analysis of EEG effective connectivity in vascular dementia patients during a visual oddball task.

Science.gov (United States)

Wang, Chao; Xu, Jin; Zhao, Songzhen; Lou, Wutao

2016-01-01

The study was dedicated to investigating the change in information processing in brain networks of vascular dementia (VaD) patients during the process of decision making. EEG was recorded from 18 VaD patients and 19 healthy controls when subjects were performing a visual oddball task. The whole task was divided into several stages by using global field power analysis. In the stage related to the decision-making process, graph theoretical analysis was applied to the binary directed network derived from EEG signals at nine electrodes in the frontal, central, and parietal regions in δ (0.5-3.5Hz), θ (4-7Hz), α1 (8-10Hz), α2 (11-13Hz), and β (14-30Hz) frequency bands based on directed transfer function. A weakened outgoing information flow, a decrease in out-degree, and an increase in in-degree were found in the parietal region in VaD patients, compared to healthy controls. In VaD patients, the parietal region may also lose its hub status in brain networks. In addition, the clustering coefficient was significantly lower in VaD patients. Impairment might be present in the parietal region or its connections with other regions, and it may serve as one of the causes for cognitive decline in VaD patients. The brain networks of VaD patients were significantly altered toward random networks. The present study extended our understanding of VaD from the perspective of brain functional networks, and it provided possible interpretations for cognitive deficits in VaD patients. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

The temporal requirement for vitamin A in the developing eye: mechanism of action in optic fissure closure and new roles for the vitamin in regulating cell proliferation and adhesion in the embryonic retina.

Science.gov (United States)

See, Angela Wai-Man; Clagett-Dame, Margaret

2009-01-01

Mammalian eye development requires vitamin A (retinol, ROL). The role of vitamin A at specific times during eye development was studied in rat fetuses made vitamin A deficient (VAD) after embryonic day (E) 10.5 (late VAD). The optic fissure does not close in late VAD embryos, and severe folding and collapse of the retina is observed at E18.5. Pitx2, a gene required for normal optic fissure closure, is dramatically downregulated in the periocular mesenchyme in late VAD embryos, and dissolution of the basal lamina does not occur at the optic fissure margin. The addition of ROL to late VAD embryos by E12.5 restores Pitx2 expression, supports dissolution of the basal lamina, and prevents coloboma, whereas supplementation at E13.5 does not. Surprisingly, ROL given as late as E13.5 completely prevents folding of the retina despite the presence of an open fetal fissure, showing that coloboma and retinal folding represent distinct VAD-dependent defects. Retinal folding due to VAD is preceded by an overall reduction in the percentage of cyclin D1 positive cells in the developing retina, (initially resulting in retinal thinning), as well as a dramatic reduction in the cell adhesion-related molecules, N-cadherin and beta-catenin. Reduction of retinal cell number combined with a loss of the normal cell-cell adhesion proteins may contribute to the collapse and folding of the retina that occurs in late VAD fetuses.

The Effect of a Voice Activity Detector on the Speech Enhancement

DEFF Research Database (Denmark)

Dau, Torsten; Catic, Jasmina; Buchholz, Jörg

2010-01-01

A multimicrophone speech enhancement algorithm for binaural hearing aids that preserves interaural time delays was proposed recently. The algorithm is based on multichannel Wiener filtering and relies on a voice activity detector (VAD) for estimation of second-order statistics. Here, the effect...... of a VAD on the speech enhancement of this algorithm was evaluated using an envelopebased VAD, and the performance was compared to that achieved using an ideal error-free VAD. The performance was considered for stationary directional noise and nonstationary diffuse noise interferers at input SNRs from −10...

A 12-bit spectroscopy analog-to-digital converter type SAA (Successive Approximation type with channel width Averaging) intended for multichannel pulse height analyzer SWAN-1 based on IBM PC/XT/AT

International Nuclear Information System (INIS)

Borsuk, S.; Kulka, Z.

1989-12-01

A 12-bit spectroscopy analog-to-digital converter (ADC) type SAA (Successive Approximation type with channel width Averaging) intended for multichannel pulse height analyzer SWAN-1 based on IBM PC/XT/AT has been described. Design principles, specifications and measurements of a fundamental SAA-2 converter version are reported. Finally, two next versions of the converter with introduced modifications are discussed. 6 refs., 7 figs. (author)

Vitamin A deficiency alters the pulmonary parenchymal elastic modulus and elastic fiber concentration in rats

Directory of Open Access Journals (Sweden)

Holmes Amey J

2005-07-01

Full Text Available Abstract Background Bronchial hyperreactivity is influenced by properties of the conducting airways and the surrounding pulmonary parenchyma, which is tethered to the conducting airways. Vitamin A deficiency (VAD is associated with an increase in airway hyperreactivity in rats and a decrease in the volume density of alveoli and alveolar ducts. To better define the effects of VAD on the mechanical properties of the pulmonary parenchyma, we have studied the elastic modulus, elastic fibers and elastin gene-expression in rats with VAD, which were supplemented with retinoic acid (RA or remained unsupplemented. Methods Parenchymal mechanics were assessed before and after the administration of carbamylcholine (CCh by determining the bulk and shear moduli of lungs that that had been removed from rats which were vitamin A deficient or received a control diet. Elastin mRNA and insoluble elastin were quantified and elastic fibers were enumerated using morphometric methods. Additional morphometric studies were performed to assess airway contraction and alveolar distortion. Results VAD produced an approximately 2-fold augmentation in the CCh-mediated increase of the bulk modulus and a significant dampening of the increase in shear modulus after CCh, compared to vitamin A sufficient (VAS rats. RA-supplementation for up to 21 days did not reverse the effects of VAD on the elastic modulus. VAD was also associated with a decrease in the concentration of parenchymal elastic fibers, which was restored and was accompanied by an increase in tropoelastin mRNA after 12 days of RA-treatment. Lung elastin, which was resistant to 0.1 N NaOH at 98°, decreased in VAD and was not restored after 21 days of RA-treatment. Conclusion Alterations in parenchymal mechanics and structure contribute to bronchial hyperreactivity in VAD but they are not reversed by RA-treatment, in contrast to the VAD-related alterations in the airways.

The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats.

Science.gov (United States)

Cao, Yanjing; Liang, Lizhen; Xu, Jian; Wu, Jiali; Yan, Yongxing; Lin, Ping; Chen, Qiang; Zheng, Fengming; Wang, Qin; Ren, Qian; Gou, Zengmei; Du, Yifeng

2016-05-01

Flavonoids have been shown to improve cognitive function and delay the dementia progression. However, the underlying mechanisms remain elusive. In the present study, we examined the effect of Scutellaria baicalensis stem-leaf total flavonoids (SSTFs) extracted from S. baicalensis Georgi on spatial learning and memory in a vascular dementia (VaD) rat model and explored its molecular mechanisms. The VaD rats were developed by permanent bilateral occlusion of the common carotid artery. Seven days after recovery, the VaD rats were treated with either 50 or 100 mg/kg of SSTF for 60 days. The spatial learning and memory was evaluated in the Morris water maze (MWM) test. The tau hyperphosphorylation and the levels of the related protein kinases or phosphatases were examined by western blot analysis. In VaD rats, SSTF treatment at 100 mg/kg significantly reduced the escape latency in training trial in MWM test. In the probe trial, SSTF treatment increased the searching time and travel distance in the target quadrant. SSTF treatment inhibited the tau phosphorylation in both cortex and hippocampus in VaD rats. Meanwhile, SSTF reduced the activity of glycogen synthase kinase 3β and cyclin-dependent kinase 5 in VaD rats. In contrast, SSTF treatment increased the level of the protein phosphatase 2A subunit B in VaD rats. SSTF treatment significantly improved the spatial cognition in VaD rats. Our results suggest that SSTF may alleviate tau-hyperphosphorylation-induced neurotoxicity through coordinating the activity of kinases and phosphatase after a stroke. SSTF may be developed into promising novel therapeutics for VaD. © The Author 2016. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

RL5SORT/RL5PLOT. A graphite package for the JRC-Ispra IBM version of RELAP5/MOD1

International Nuclear Information System (INIS)

Kolar, W.; Brewka, W.

1984-01-01

The present report describes the programs RL5SORT and RL5PLOT, their implementation and ''how to use''. Both programs base on the IBM version of RELAP5 as developed at JRC-ISPRA. RL5SORT creates from the output file (restart plot file) of a RELAP5 calculation data files, which serve as input data base for the program RL5PLOT. RL5PLOT retrieves the previous stored data records (minor edit quantities of RELAP5), allows arithmetic operations with the retrieved data and enables a print or graphic output on the terminal screen of a TEKTRONIX graphic terminal. A set of commands, incorporated in the program RL5PLOT, facilitates the user's work. Program RL5SORT has been developed as a batch program, while RL5PLOT has been conceived for interactive working mode

Utilizing Current Commercial-off-the-Shelf Facial Recognition and Public Live Video Streaming to Enhance National Security

Science.gov (United States)

2014-09-01

7 Figure 4. FBI RISC Process Flow Diagram(from Mayo, 2011) .......................................9...justice purposes, such as criminal background checks for employment purposes. In addition, the Repository for Individuals of Special Concern ( RISC ) is a...wanted persons, suspected terrorists, and sex offenders. The RISC system is optimized to provide very quick access to information based on the level

Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia

Directory of Open Access Journals (Sweden)

Tushar Kanti Bandyopadhyay

2014-01-01

Full Text Available Background/Aims: The aim of the following study is to compare the behavioral and psychological symptoms of dementia (BPSD in patients of Alzheimer disease (AD and vascular dementia (VaD. Materials and Methods: We used National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer′s Disease and Related Disorders Association criteria for diagnosing AD and National Institute of Neurological Disorders and Stroke-Association International pour la Recherche et l′Enseignement en Neurosciences Criteria for diagnosing VaD. VaD cohort was further subcategorized into small vessel and large vessel disease. The severity of cognitive impairment and the BPSD were studied by means of the Clinical Dementia Rating Scale (CDR and the Neuropsychiatric Inventory respectively. Results: We studied 50 AD and 50 VaD patients of whom 38 were small vessels and 12 were large vessels VaD. The severity of dementia was comparable in both groups. The agitation/aggression, depression/dysphoria, anxiety, apathy/indifference, irritability, aberrant motor behavior, appetite and eating behavior and night-time behaviors occurred significantly more frequently in patients with VaD than AD. We found a weak positive correlation between the CDR score and the number of neuropsychiatric symptoms per patient in both cohorts. Elation/euphoria, agitation/aggression was significantly more frequent in patients with large vessel in comparison to small vessel VaD. Conclusions: BPSD are common in both types of dementia and they are more severe in VaD than AD when the groups have similar levels of cognitive impairment.

A Semi-Continuous State-Transition Probability HMM-Based Voice Activity Detector

Directory of Open Access Journals (Sweden)

H. Othman

2007-02-01

Full Text Available We introduce an efficient hidden Markov model-based voice activity detection (VAD algorithm with time-variant state-transition probabilities in the underlying Markov chain. The transition probabilities vary in an exponential charge/discharge scheme and are softly merged with state conditional likelihood into a final VAD decision. Working in the domain of ITU-T G.729 parameters, with no additional cost for feature extraction, the proposed algorithm significantly outperforms G.729 Annex B VAD while providing a balanced tradeoff between clipping and false detection errors. The performance compares very favorably with the adaptive multirate VAD, option 2 (AMR2.

A Semi-Continuous State-Transition Probability HMM-Based Voice Activity Detector

Directory of Open Access Journals (Sweden)

Othman H

2007-01-01

Full Text Available We introduce an efficient hidden Markov model-based voice activity detection (VAD algorithm with time-variant state-transition probabilities in the underlying Markov chain. The transition probabilities vary in an exponential charge/discharge scheme and are softly merged with state conditional likelihood into a final VAD decision. Working in the domain of ITU-T G.729 parameters, with no additional cost for feature extraction, the proposed algorithm significantly outperforms G.729 Annex B VAD while providing a balanced tradeoff between clipping and false detection errors. The performance compares very favorably with the adaptive multirate VAD, option 2 (AMR2.

Relational-interdependent self-construal as a predictor of relationship quality: the mediating roles of one's own behaviors and perceptions of the fulfillment of friendship functions.

Science.gov (United States)

Morry, Marian M; Kito, Mie

2009-06-01

Relational-interdependent self-construal (RISC) is the tendency to think of oneself in terms of relationships with close others, and it influences relationship cognitions (e.g., closeness, commitment, perceived similarity). The authors expected individuals high in RISC to report more relationship supportive behaviors (RSB; e.g., higher levels of trust, more intimate disclosures), experience greater fulfillment of friendship functions (FrFu; e.g., help, emotional security, stimulating companionship), and report higher relationship quality than individuals low in RISC. The authors also hypothesized that RSB would mediate the RISC-friendship function and the RISC-relationship quality relations and that FrFu would mediate the relation between RSB and relationship quality. Structural equation modeling supported the authors' hypotheses. These effects did not differ across friendship type (same or cross sex). The authors discuss the importance of self-construal for relationship research.

Relationship between vitamin A deficiency and the thyroid axis in clinically stable patients with liver cirrhosis related to hepatitis C virus.

Science.gov (United States)

El-Eshmawy, Mervat M; Arafa, Mona M; Elzehery, Rasha R; Elhelaly, Rania M; Elrakhawy, Mohamed M; El-Baiomy, Azza A

2016-09-01

Vitamin A deficiency (VAD) and altered thyroid function are commonly encountered in patients with liver cirrhosis. The link between vitamin A metabolism and thyroid function has been previously identified. The aim of this study was to explore the association between VAD and the thyroid axis in clinically stable patients with cirrhosis related to hepatitis C virus (HCV). One hundred and twelve patients with clinically stable HCV-related cirrhosis and 56 healthy controls matched for age, sex, and socioeconomic status were recruited for this study. Vitamin A status, liver function, thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), reverse triiodothyronine (rT3), anti-thyroid peroxidase antibodies (anti-TPO), and thyroid volume were evaluated. The prevalence of VAD among patients with HCV-related cirrhosis was 62.5% compared with 5.4% among controls (P vitamin A status: VAD and normal vitamin A. Patients with VAD had significantly lower vitamin A intake and serum albumin and higher serum bilirubin, FT4, FT3, and TSH than patients with normal vitamin A status. Multiple logistic regression analysis revealed that VAD was associated with Child-Pugh score (β = 0.11, P = 0.05) and TSH (β = -1.63, P = 0.02) independently of confounding variables. We conclude that VAD may be linked to central hyperthyroidism in patients with clinically stable HCV-related liver cirrhosis.

Systemic and Disease-Specific Risk Factors in Vascular Dementia: Diagnosis and Prevention

Directory of Open Access Journals (Sweden)

Efraim Jaul

2017-10-01

Full Text Available In order to prevent the onset of vascular dementia (VaD in aging individuals, it is critical to detect clinically relevant vascular and systemic pathophysiological changes to signal the onset of its preceding prodromal stages. Identifying behavioral and neurobiological markers that are highly sensitive to VaD classification vs. other dementias is likely to assist in developing novel preventive treatment strategies that could delay the onset of disruptive psychomotor symptoms, decrease hospitalizations, and increase the quality of life in clinically-high-risk aging individuals. In light of empirical diagnostic and clinical findings associated with VaD pathophysiology, the current investigation will suggest a few clinically-validated biomarker measures of prodromal VaD cognitive impairments that are correlated with vascular symptomology, and VaD endophenotypes in non-demented aging people. In prodromal VaD individuals, distinguishing VaD from other dementias (e.g., Alzheimer's disease could facilitate specific early preventive interventions that significantly delay more severe cognitive deterioration or indirectly suppress the onset of dementia with vascular etiology. Importantly, the authors conclude that primary prevention strategies should examine aging individuals by employing comprehensive geriatric assessment approach, taking into account their medical history, and longitudinally noting their vascular, systemic, cognitive, behavioral, and clinical functional status. Secondary prevention strategies may include monitoring chronic medication as well as promoting programs that facilitate social interaction and every-day activities.

IODP Expedition 351 Lithostratigraphy: Volcaniclastic Record of Izu-Bonin-Mariana (IBM) Arc Initiation

Science.gov (United States)

Barth, A. P.; Brandl, P. A.; Li, H.; Hickey-Vargas, R.; Jiang, F.; Kanayama, K.; Kusano, Y.; Marsaglia, K. M.; McCarthy, A.; Meffre, S.; Savov, I. P.; Tepley, F. J., III; Yogodzinski, G. M.

2014-12-01

The destruction of lithospheric plates by subduction is a fundamentally important process leading to arc magmatism and the creation of continental crust, yet subduction initiation and early magmatic arc evolution remain poorly understood. For many arc systems, onset of arc volcanism and early evolution are obscured by metamorphism or the record is deeply buried; however, initial products of arc systems may be preserved in forearc and backarc sedimentary records. IODP Expedition 351 recovered this history from the dispersed ash and pyroclast record in the proximal rear-arc of the northern IBM system west of the Kyushu-Palau Ridge. Drilling at Site U1438 in the Amami Sankaku Basin recovered a thick volcaniclastic record of subduction initiation and the early evolution of the Izu-Bonin Arc. A 160-m thick section of Neogene sediment overlies 1.3 kilometers of Paleogene volcaniclastic rocks with andesitic average composition; this volcaniclastic section was deposited on mafic volcanic basement rocks. The thin upper sediment layer is primarily terrigenous, biogenic and volcaniclastic mud and ooze with interspersed ash layers. The underlying Eocene to Oligocene volcaniclastic rocks are 33% tuffaceous mudstone, 61% tuffaceous sandstone, and 6% conglomerate with volcanic and rare sedimentary clasts commonly up to pebble and rarely to cobble size. The clastic section is characterized by repetitive conglomerate and sandstone-dominated intervals with intervening mudstone-dominated intervals, reflecting waxing and waning of coarse arc-derived sediment inputs through time. Volcanic lithic clasts in sandstones and conglomerates range from basalt to rhyolite in composition and include well-preserved pumice, reflecting a lithologically diverse and compositionally variable arc volcanic source.

Desain Mikroprosessor Menggunakan Perangkat Lunak MAX+PLUS II

OpenAIRE

Niswar, Muhammad; Ilham, Amil Ahmad

2014-01-01

Mikroprosessor umumnya dibedakan berdasarkan tingkat kerumitan arsitekturnya (instruction set). Berdasarkan kriteria ini maka mikroprosessor dapat dibagi menjadi dua jenis yaitu CISC (Complex Instruction Set Computer) dan RISC (Reduced Instruction Set Computer). Salah satu kelebihan utama mikroprosessor RISC dibandingkan dengan CISC adalah kemampuannya untuk mengeksekusi program yang relatif lebih cepat. Hal ini disebabkan karena kecepatan clock pada mikroprosessor RISC lebih tinggi dari p...

MAQUETTE ORL Décembre 2004

African Journals Online (AJOL)

le cancer des VADS ainsi que ses thérapies, la recherche ... les cancers des VADS, il faut commencer très précocement avant même ... support should always be preferred. ... D'une manière générale, la tumeur se développe quelque .... patients pris en charge en ORL pour cancer des VADS .... Evaluation nutritionnelle.

Soil-Transmitted Helminthiasis and Vitamin A Deficiency: Two Problems, One Policy.

Science.gov (United States)

Strunz, Eric C; Suchdev, Parminder S; Addiss, David G

2016-01-01

Vitamin A deficiency (VAD) and soil-transmitted helminthiasis (STH) represent two widely prevalent and often overlapping global health problems. Approximately 75% of countries with moderate or severe VAD are coendemic for STH. We reviewed the literature on the complex relationship between STH and VAD. Treatment for STH significantly increases provitamin A (e.g., β-carotene) levels but is associated with minimal increases in preformed vitamin A (retinol). Interpretation of the data is complicated by variations in STH infection intensity and limitations of vitamin A biomarkers. Despite these challenges, increased coordination of STH and VAD interventions represents an important public health opportunity. Copyright © 2015 Elsevier Ltd. All rights reserved.

Outcomes of pediatric patients supported with continuous-flow ventricular assist devices: A report from the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS).

Science.gov (United States)

Rossano, Joseph W; Lorts, Angela; VanderPluym, Christina J; Jeewa, Aamir; Guleserian, Kristine J; Bleiweis, Mark S; Reinhartz, Olaf; Blume, Elizabeth D; Rosenthal, David N; Naftel, David C; Cantor, Ryan S; Kirklin, James K

2016-05-01

Continuous-flow (CF) ventricular assist devices (VADs) have largely replaced pulsatile-flow VADs in adult patients. However, there are few data on CF VADs among pediatric patients. In this study we aimed to describe the overall use, patients' characteristics and outcomes of CF VADs in this population. The Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS) is a national registry for U.S. Food and Drug Adminstration (FDA)-approved VADs in patients <19 years of age. Patients undergoing placement of durable CF VADs between September 2012 and June 2015 were included and outcomes were compared with those of adults from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). CF VADs were implanted in 109 patients at 35 hospitals. The median age at implantation was 15 years (2.8 to 18.9 years) and median weight was 62 kg (range 16 to 141 kg). The underlying disease was cardiomyopathy in 89 (82%) patients. The INTERMACS level at time of implant was Level 1 in 20 (19%), Level 2 in 64 (61%) and Levels 3 to 7 in 21 (20%) patients. Most were implanted as LVADs (n = 102, 94%). Median duration of support was 2.3 months (range <1 day to 28 months). Serious adverse event rates were low, including neurologic dysfunction (early event rate 4.1 per 100 patient-months with 2 late events). Competing outcomes analysis at 6 months post-implant indicated 61% transplanted, 31% alive with device in place and 8% death before transplant. These outcomes compared favorably with the 3,894 adults supported with CF VADs as a bridge to transplant. CF VADs are commonly utilized in older children and adolescents, with excellent survival rates. Further study is needed to understand impact of patient and device characteristics on outcomes in pediatric patients. Copyright © 2016 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

Exercise physiology with a left ventricular assist device: Analysis of heart-pump interaction with a computational simulator.

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Fresiello, Libera; Rademakers, Frank; Claus, Piet; Ferrari, Gianfranco; Di Molfetta, Arianna; Meyns, Bart

2017-01-01

Patients with a Ventricular Assist Device (VAD) are hemodynamically stable but show an impaired exercise capacity. Aim of this work is to identify and to describe the limiting factors of exercise physiology with a VAD. We searched for data concerning exercise in heart failure condition and after VAD implantation from the literature. Data were analyzed by using a cardiorespiratory simulator that worked as a collector of inputs coming from different papers. As a preliminary step the simulator was used to reproduce the evolution of hemodynamics from rest to peak exercise (ergometer cycling) in heart failure condition. Results evidence an increase of cardiac output of +2.8 l/min and a heart rate increase to 67% of the expected value. Then, we simulated the effect of a continuous-flow VAD at both rest and exercise. Total cardiac output increases of +3.0 l/min (+0.9 l/min due to the VAD and +2.1 l/min to the native ventricle). Since the left ventricle works in a non-linear portion of the diastolic stiffness line, we observed a consistent increase of pulmonary capillary wedge pressure (from 14 to 20 mmHg) for a relatively small increase of end-diastolic volume (from 182 to 189 cm3). We finally increased VAD speed during exercise to the maximum possible value and we observed a reduction of wedge pressure (-4.5 mmHg), a slight improvement of cardiac output (8.0 l/min) and a complete unloading of the native ventricle. The VAD can assure a proper hemodynamics at rest, but provides an insufficient unloading of the left ventricle and does not prevent wedge pressure from rising during exercise. Neither the VAD provides major benefits during exercise in terms of total cardiac output, which increases to a similar extend to an unassisted heart failure condition. VAD speed modulation can contribute to better unload the ventricle but the maximal flow reachable with the current devices is below the cardiac output observed in a healthy heart.

PDSparc: A Drop-In Replacement for LEON3 Written Using Synopsys Processor Designer

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2015-09-24

Instruction Set Computers (CISC), in which complex operations are rolled up into single instructions, and Reduced Instruction Set Computers ( RISC ), in...of RISC over CISC architectures are many, including the ability to easily pipeline operations (because all or most operations take the same amount of...time to execute), and speed, as critical paths can be much shorter. The RISC model is good for generalized computing, in which a wide variety of

Efficacy Of Rivastigmine And Donepezil On Cognitive Impairment Of Vascular Dementia - Some Preliminary Observations

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Jha S

2004-01-01

Full Text Available Background: Vascular Dementia (VaD is common, global, disabling and a rather neglected, age related dementia. It is important to identify and treat it since cognitive impairment produces dysfunction in occupational and social life. Moreso, due to increase in geriatric population, incidence and prevalence of VaD is also increasing. Aim: We share our observations on efficacy of Rivastigmine and Donepezil (drugs advocated for improving cognition in dementia in patients of VaD. Material and Method: This was a non-randomized study based on clinical evaluation. We selected 53 patients suffering from VaD (as per clinical and radiological criteria. Their age range was 55-78 years (mean 65.3 + 6.2 yrs. Clinical, biochemical and radiological (Cranial CT and MRI evaluation was done to establish etiology. Cognition was measured using modified Mini Mental State Examination (MMSE which was repeated 2 times, at interval of 3 months. We observed the role of Rivastigmine in 14 and Donepezil in 19 patients of VaD. The change in MMSE score was compared with 20 control patients of VaD. The associated risk factors like hypertension, diabetes, hyperlipidemia etc. were managed. Acetyl Salicylic Acid (ASA in dose of 150mg/day was given as an antiplatelet agent to all 53 patients in this study. Results: At end of study, no statistically significant improvement was observed in MMSE score in any of the 53 patients. Improvement in MMSE score (though statistically insignificant was observed with Rivastigmine in 11 and with Donepezil in 14 patients. Progressive decline in MMSE score was observed in 14 (70% control patients of VaD who did not receive rivastigmine or donepezil. Conclusion - Rivastigmine and Donepezil are beneficial in halting deterioration of dementia in patients suffering from VaD.

Use of Ventricular Assist Device in Univentricular Physiology: The Role of Lumped Parameter Models.

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Di Molfetta, Arianna; Ferrari, Gianfranco; Filippelli, Sergio; Fresiello, Libera; Iacobelli, Roberta; Gagliardi, Maria G; Amodeo, Antonio

2016-05-01

Failing single-ventricle (SV) patients might benefit from ventricular assist devices (VADs) as a bridge to heart transplantation. Considering the complex physiopathology of SV patients and the lack of established experience, the aim of this work was to realize and test a lumped parameter model of the cardiovascular system, able to simulate SV hemodynamics and VAD implantation effects. Data of 30 SV patients (10 Norwood, 10 Glenn, and 10 Fontan) were retrospectively collected and used to simulate patients' baseline. Then, the effects of VAD implantation were simulated. Additionally, both the effects of ventricular assistance and cavopulmonary assistance were simulated in different pathologic conditions on Fontan patients, including systolic dysfunction, diastolic dysfunction, and pulmonary vascular resistance increment. The model can reproduce patients' baseline well. Simulation results suggest that the implantation of VAD: (i) increases the cardiac output (CO) in all the three palliation conditions (Norwood 77.2%, Glenn 38.6%, and Fontan 17.2%); (ii) decreases the SV external work (SVEW) (Norwood 55%, Glenn 35.6%, and Fontan 41%); (iii) increases the mean pulmonary arterial pressure (Pap) (Norwood 39.7%, Glenn 12.1%, and Fontan 3%). In Fontan circulation, with systolic dysfunction, the left VAD (LVAD) increases CO (35%), while the right VAD (RVAD) determines a decrement of inferior vena cava pressure (Pvci) (39%) with 34% increment of CO. With diastolic dysfunction, the LVAD increases CO (42%) and the RVAD decreases the Pvci. With pulmonary vascular resistance increment, the RVAD allows the highest CO (50%) increment with the highest decrement of Pvci (53%). The single ventricular external work (SVEW) increases (decreases) increasing the VAD speed in cavopulmonary (ventricular) assistance. Numeric models could be helpful in this challenging and innovative field to support patients and VAD selection to optimize the clinical outcome and personalize the therapy

Features and selection of vascular access devices.

Science.gov (United States)

Sansivero, Gail Egan

2010-05-01

To review venous anatomy and physiology, discuss assessment parameters before vascular access device (VAD) placement, and review VAD options. Journal articles, personal experience. A number of VAD options are available in clinical practice. Access planning should include comprehensive assessment, with attention to patient participation in the planning and selection process. Careful consideration should be given to long-term access needs and preservation of access sites. Oncology nurses are uniquely suited to perform a key role in VAD planning and placement. With knowledge of infusion therapy, anatomy and physiology, device options, and community resources, nurses can be key leaders in preserving vascular access and improving the safety and comfort of infusion therapy. Copyright 2010 Elsevier Inc. All rights reserved.

What on earth is a mainframe ? an introduction to IBM zSeries mainframes and z/OS operating systems for total beginners

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Stephens, David

2008-01-01

Looking for a "Mainframes for Beginners" book? Need to learn about z/OS fast? Then this is the book you need. This is the perfect introduction to IBM System z Mainframes and z/OS. Avoiding technical jargon, it gives you the basic facts in clear, light-hearted, entertaining English. You'll quickly learn what Mainframes are, what they do, what runs on them, and terms and terminology you need to speak Mainframe-ese. But it's not all technical. There's also invaluable information about the people that work on Mainframes, Mainframe management issues, new Mainframe trends, and other facts that don't seem to be written down anywhere else. What On Earth is a Mainframe is the closest you'll get to a "Mainframes for Dummies" book. Programmers, managers, recruitment consultants, and industry commentators will all find this book their new best friend when trying to understand the Mainframe world.

A Survey of Research in Supervisory Control and Data Acquisition (SCADA)

Science.gov (United States)

2014-09-01

RISC ) platforms running some version of UNIX.4 Around the turn of the millennium work began on applying Web technologies to SCADA systems.5–8 Lately...the 2 trend has been to move from the UNIX/ RISC system to commodity hardware and Microsoft solutions although there is some Linux,1 to move from...Control Center MTU Master Terminal Unit OS operating system PKI Public Key Infrastructure PLC Programmable Logic Controller RISC Reduced Instruction