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Sample records for urbana ix three-nucleon

  1. Complete Set of Deuteron Analyzing Powers for dp Elastic Scattering at 250 MeV/nucleon and Three Nucleon Forces

    Directory of Open Access Journals (Sweden)

    Shimizu Y.

    2010-04-01

    Full Text Available Measurements of a complete set of deuteron analyzing powers (iT11, T20, T21, T22 for elastic deuteron–proton scattering at 250 MeV/nucleon have been performed with polarized deuteron beams at RIKEN RI Beam Factory. The obtained data are compared with the Faddeev calculations based on the modern nucleon–nucleon forces together with the Tucson-Melbourne’99, and UrbanaIX three nucleon forces.

  2. Three-nucleon forces

    International Nuclear Information System (INIS)

    Sauer, P.U.

    2014-01-01

    In this paper, the role of three-nucleon forces in ab initio calculations of nuclear systems is investigated. The difference between genuine and induced many-nucleon forces is emphasized. Induced forces arise in the process of solving the nuclear many-body problem as technical intermediaries toward calculationally converged results. Genuine forces make up the Hamiltonian. They represent the chosen underlying dynamics. The hierarchy of contributions arising from genuine two-, three- and many-nucleon forces is discussed. Signals for the need of the inclusion of genuine three-nucleon forces are studied in nuclear systems, technically best under control, especially in three-nucleon and four-nucleon systems. Genuine three-nucleon forces are important for details in the description of some observables. Their contributions to observables are small on the scale set by two-nucleon forces. (author)

  3. Three-Nucleon Forces and Triplet Pairing in Neutron Matter

    Science.gov (United States)

    Papakonstantinou, P.; Clark, J. W.

    2017-12-01

    The existence of superfluidity of the neutron component in the core of a neutron star, associated specifically with triplet P-wave pairing, is currently an open question that is central to interpretation of the observed cooling curves and other neutron-star observables. Ab initio theoretical calculations aimed at resolving this issue face unique challenges in the relevant high-density domain, which reaches beyond the saturation density of symmetrical nuclear matter. These issues include uncertainties in the three-nucleon (3N) interaction and in the effects of strong short-range correlations—and more generally of in-medium modification of nucleonic self-energies and interactions. A survey of existing solutions of the gap equations in the triplet channel demonstrates that the net impact on the gap magnitude of 3N forces, coupled channels, and mass renormalization shows extreme variation dependent on specific theoretical inputs, in some cases even pointing to the absence of a triplet gap, thus motivating a detailed analysis of competing effects within a well-controlled model. In the present study, we track the effects of the 3N force and in-medium modifications in the representative case of the ^3P_2 channel, based on the Argonne v_{18} two-nucleon (2N) interaction supplemented by 3N interactions of the Urbana IX family. Sensitivity of the results to the input interaction is clearly demonstrated. We point out consistency issues with respect to the simultaneous treatment of 3N forces and in-medium effects, which warrant further investigation. We consider this pilot study as the first step toward a systematic and comprehensive exploration of coupled-channel ^3P F_2 pairing using a broad range of 2N and 3N interactions from the current generation of refined semi-phenomenological models and models derived from chiral effective field theory.

  4. Qualitative treatment of three-nucleon properties

    International Nuclear Information System (INIS)

    Efimov, V.

    1981-01-01

    An attempt is made at consistent qualitative treatment of the three-nucleon system. The approach used is based on the physical concept of effective three-nucleon long-range interaction resulting from the existence of the deuteron and the virtual singlet deuteron. Within the framework of the approach, a qualitative treatment of the triton properties, nucleon-deuteron scattering, and triton-disintegration reactions is carried out. The following topics are dealt with: the Phillips line, the triton D-wave admixture, the doublet effective range of the n-d scattering, the triton virtual state, the anomaly of the n-d elastic cross section near the three-body threshold, and the partial cross sections of the inelastic n-d scattering and of the triton photo- and electrodisintegration. The discussion of these topics includes the evaluation of three-nucleon parameters and the qualitative interpretation of experimental data and calculation results; some predictions are also made. The results of our analysis lead to the conclusion that the concept of effective three-nucleon long-range interaction can indeed serve as grounds for consistent qualitative treatment of the three-nucleon phenomena. (orig.)

  5. Relativistic origin of three-nucleon force

    International Nuclear Information System (INIS)

    Haberzettl, H.; Parke, W.C.

    1995-01-01

    Based on the manifestly covariant cluster-dynamical formalism recently proposed by Haberzettl, the three-body forces entering three-nucleon equations are discussed. It is shown that there exist additional contributions to the (nonrelativistic) three-body force, not taken into account in the usual treatments, arising from the proper nonrelativistic limits of higher-order meson-exchange Feynman diagrams. Using the Paris potential, a five-channel triton bound-state calculation results in additional binding of about 0.6 MeV due to this new mechanism. copyright 1995 American Institute of Physics

  6. Three nucleon interaction and nuclear composition

    International Nuclear Information System (INIS)

    Pandharipande, V.R.

    1983-01-01

    The author discusses results of some of the calculations carried out by J. Carlson, I. Lagaris, J. Lomnitz-Adler, R.A. Smith, R.B. Wiringa and himself to study the three nucleon interaction. The group has attempted to calculate the wavefunctions and binding energies of 3 H, 3 He, 4 He and nuclear matter, with the variational method, from a nonrelativistic Hamiltonian. Only nucleon degrees of freedom are retained in this Hamiltonian; the effects of other degrees of freedom are implicit in the two and three nucleon potentials. The author discusses further the calculations carried out, in collaboration with B. Friman, and R.B. Wiringa, to study the composition of nuclei. Nucleons interact by many processes including exchange of pions with or without excitation to isobar (Δ) states. Thus the nucleus contains pions being exchanged, and some nucleons in the Δ state. The group attempts to calculate the number and momentum distribution of these exchanged pions, and the fraction of time a nucleon in the nucleus is in the Δ state. 21 references, 4 figures

  7. Three-nucleon forces and their importance in three-nucleon sys- tems and heavier nuclei

    NARCIS (Netherlands)

    Kalantar-Nayestanaki, N.

    2014-01-01

    Abstract In the past two decades, several laboratories have produced a large amount of data for cross sections, analyzing powers, and other spin observables from various reactions in the three-nucleon system. The experimental results are moderately described by only using the two-nucleon potentials

  8. Three-nucleon scattering by using chiral perturbation theory potential

    International Nuclear Information System (INIS)

    Kamata, Hiroyuki

    2003-01-01

    Three-nucleon scattering problems are studied by using two-nucleon and three-nucleon potentials derived from chiral perturbation theory. The three-nucleon term is shown to appear in the effective potential of the rank of next-to-next-to-leading order (NNLO). New three-nucleon forces are taken into consideration in addition to the conventional Fujita-Miyazawa (FM) type three-nucleon potential. Two-nucleon potential of the chiral perturbation theory is as precise as the conventional ones in low energy region. The FM type three-nucleon force which explains Sagara discrepancy in high energy region is introduced automatically. Concerning the Ay puzzle, the results seems to behave as if the puzzle has been solved at the level of NLO, but at the NNLO (without three-nucleon force) level the result is similar to the cases of conventional potential indicating the need of three-nucleon force. In contrast to the FM type three-nucleon force, five free parameters exist in the new D and E type three-nucleon forces introduced by the NNLO, but they are reduced to two independent parameters by antisymmetrization, which are found to be sensitive to the coupling energy of tritons and to the nd scattering length (spin doublet state). Parameters determined from them cannot give satisfactory answer to the A y puzzle. It seems, however, too hasty to conclude that A y puzzle cannot be solved by the chiral perturbation theory. (S. Funahashi)

  9. Evaluation of the three-nucleon analyzing power puzzle

    International Nuclear Information System (INIS)

    Tornow, W.; Witala, H.

    1998-01-01

    The current status of the three-nucleon analyzing power puzzle is reviewed. Applying tight constraints on the allowed deviations between calculated predictions and accepted values for relevant nucleon-nucleon observables reveals that energy independent correction factors applied to the 3 P j nucleon-nucleon interactions can not solve the puzzle. Furthermore, using the same constraints, charge-independence breaking in the 3 P j nucleon-nucleon interactions can be ruled out as a possible tool to improve the agreement between three-nucleon calculations and data. The study of the energy dependence of the three-nucleon analyzing power puzzle gives clear evidence that the 3 P j nucleon-nucleon interaction obtained from phase-shift analyses and used in potential models are correct above about 25 MeV, i.e., the 3 P j nucleon-nucleon interactions have to be modified only at lower energies in order to solve the three-nucleon analyzing power puzzle, unless new three-nucleon forces can be found that account for the three-nucleon analyzing power puzzle without destroying the beautiful agreement between rigorous three-nucleon calculations and a large body of accurate three-nucleon data. (orig.)

  10. Three-nucleon forces and the trinucleon bound states

    International Nuclear Information System (INIS)

    Friar, J.L.; Frois, B.

    1986-04-01

    A summary of the bound-state working group session of the ''International Symposium on the Three-Body Force in the Three-Nucleon System'' is presented. The experimental evidence for three-nucleon forces has centered on two ground state properties: the tritium binding energy and the trinucleon form factors. Both are discussed

  11. Evaluation of the three-nucleon analyzing power puzzle

    Energy Technology Data Exchange (ETDEWEB)

    Tornow, W. [Duke Univ., Durham, NC (United States). Dept. of Physics]|[Triangle Univ. Nuclear Lab., Durham, NC (United States); Witala, H. [Uniwersytet Jagiellonski, Cracow (Poland). Inst. Fizyki

    1998-07-20

    The current status of the three-nucleon analyzing power puzzle is reviewed. Applying tight constraints on the allowed deviations between calculated predictions and accepted values for relevant nucleon-nucleon observables reveals that energy independent correction factors applied to the {sup 3}P{sub j} nucleon-nucleon interactions can not solve the puzzle. Furthermore, using the same constraints, charge-independence breaking in the {sup 3}P{sub j} nucleon-nucleon interactions can be ruled out as a possible tool to improve the agreement between three-nucleon calculations and data. The study of the energy dependence of the three-nucleon analyzing power puzzle gives clear evidence that the {sup 3}P{sub j} nucleon-nucleon interaction obtained from phase-shift analyses and used in potential models are correct above about 25 MeV, i.e., the {sup 3}P{sub j} nucleon-nucleon interactions have to be modified only at lower energies in order to solve the three-nucleon analyzing power puzzle, unless new three-nucleon forces can be found that account for the three-nucleon analyzing power puzzle without destroying the beautiful agreement between rigorous three-nucleon calculations and a large body of accurate three-nucleon data. (orig.) 18 refs.

  12. Three-nucleon problem with phase equivalent potentials

    International Nuclear Information System (INIS)

    Pushkash, O.M.; Shapoval, D.V.; Simenog, I.V.

    1991-01-01

    The effect of the t-matrix off-shell variations with nonlocal phase equivalent N-N potentials on the three-nucleon parameters is studied. The variations, which lower or increase the tritium binding energy, are revealed. We show that under certain conditions, the three-nucleon low-energy observables are almost insensitive to the high energy behaviour of the negative parts of the scattering phase shifts. The inverse problem method is applied to reconstruct simple S-wave potentials which to provide a unified description of the two-nucleon and low-energy three-nucleon data. 22 refs.; 6 figs. (author)

  13. Δ-excitations and the three-nucleon force

    International Nuclear Information System (INIS)

    Epelbaum, E.; Krebs, H.; Meissner, Ulf-G.

    2008-01-01

    We study the three-nucleon force in chiral effective field theory with explicit Δ-resonance degrees of freedom. We show that up to next-to-next-to-leading order, the only contribution to the isospin symmetric three-nucleon force involving the spin-3/2 degrees of freedom is given by the two-pion-exchange diagram with an intermediate delta, frequently called the Fujita-Miyazawa force. We also analyze the leading isospin-breaking corrections due to the delta. For that, we give the first quantitative analysis of the delta quartet mass splittings in chiral effective field theory including the leading electromagnetic corrections. The charge-symmetry breaking three-nucleon force due to an intermediate delta excitation is small, of the order of a few keV

  14. Quark cluster model in the three-nucleon system

    International Nuclear Information System (INIS)

    Osman, A.

    1986-11-01

    The quark cluster model is used to investigate the structure of the three-nucleon systems. The nucleon-nucleon interaction is proposed considering the colour-nucleon clusters and incorporating the quark degrees of freedom. The quark-quark potential in the quark compound bag model agrees with the central force potentials. The confinement potential reduces the short-range repulsion. The colour van der Waals force is determined. Then, the probability of quark clusters in the three-nucleon bound state systems are numerically calculated using realistic nuclear wave functions. The results of the present calculations show that quarks cluster themselves in three-quark systems building the quark cluster model for the trinucleon system. (author)

  15. Three-body force in the three-nucleon system

    International Nuclear Information System (INIS)

    Gibson, B.F.

    1986-01-01

    A brief summary of the symposium is presented. Three-nucleon force models are discussed, including the two-pion exchange potential, NN-ΔN coupled-channels model, and phenomenological parametrization. Relevant experimental data and model calculations are discussed including form factors, binding energies, charge radii, and charge density for 3 H and 3 He. A calculation of the EMC effect for 3 He is also made using Sasakawa's wave function and compared to experimental data obtained at SLAC. The paper ends with discussions of proton-deuteron scattering, investigations at intermediate energies, and QCD efforts to understand the three-body problem

  16. The Sendai triton calculation with three-nucleon potentials

    International Nuclear Information System (INIS)

    Sasakawa, T.

    1986-01-01

    Where can we see the effects of quarks remains a fundamental question in nuclear theory physics. A bold approach is to try to reproduce physical quantities theoretically by utilizing a quark picture with imagination. A conservative but safer approach may be to study the triton as thoroughly as possible using realistic two- and three-nucleon potentials. We are taking the latter approach. In fact, our calculation of the EMC effect, which was one thought to be a realization of the quark-gluon picture of nuclei, suggests that we might not have to make recourse to this picture. The calculation was done for 3 He, while experimental data for 4 He are shown. We hope that an experiment for 3 He is done soon, to check whether our conservative approach actually works for the EMC effect. (orig./WL)

  17. Configuration space methods in the three-nucleon problem

    International Nuclear Information System (INIS)

    Friar, J.L.

    1985-01-01

    The assumptions underlying the formulation and solution of the Schroedinger equation for three nucleons in configuration space are reviewed. Those qualitative aspects of the two-nucleon problem which play an important role in the trinucleon are discussed. The geometrical aspects of the problem are developed, and the importance of the angular momentum barrier is demonstrated. The Faddeev-Noyes formulation of the Schroedinger equation is motivated, and the boundary conditions for various three-body problems is reviewed. The method of splines is shown to provide a particularly useful numerical modelling technique for solving the Faddeev-Noyes equation. The properties of explicit trinucleon solutions for various two-body force models are discussed, and the evidence for three-body forces is reviewed. The status of calculations of trinucleon observables is discussed, and conclusions are presented. 40 refs., 14 figs

  18. Comparative study of three-nucleon potentials in nuclear matter

    Science.gov (United States)

    Lovato, Alessandro; Benhar, Omar; Fantoni, Stefano; Schmidt, Kevin E.

    2012-02-01

    A new generation of local three-body potentials providing an excellent description of the properties of light nuclei, as well as of the neutron-deuteron doublet scattering length, has been recently derived. We have performed a comparative analysis of the equations of state of both pure neutron matter (PNM) and symmetric nuclear matter (SNM) at zero temperature obtained using these models of three-nucleon forces. In particular, we have carried out both variational and auxiliary field diffusion Monte Carlo calculations of the equation of state of PNM, while in the case of SNM we have only the variational approach has been considered. None of the considered potentials simultaneously explains the empirical equilibrium density and binding energy of symmetric nuclear matter. However, two of them provide reasonable values of the saturation density. The ambiguity concerning the treatment of the contact term of the chiral inspired potentials is discussed.

  19. Three-nucleon hadronic and electromagnetic reactions with Δ-isobar excitation

    International Nuclear Information System (INIS)

    Deltuva, A.; Adam, J. Jr.; Fonseca, A.C.; Sauer, P.U.

    2005-01-01

    Three-nucleon hadronic and electromagnetic reactions are described. The description uses the purely nucleonic charge-dependent CD-Bonn potential and its coupled-channel extension CD-Bonn + Δ. Exact solutions of three-particle equations are employed for the initial and final states of the reactions. The Δ-isobar excitation yields an effective three-nucleon force and effective two- and three-nucleon currents beside other Δ-isobar effects; they are mutually consistent

  20. Electromagnetic properties of the three-nucleon ground state

    International Nuclear Information System (INIS)

    Strueve, W.

    1985-01-01

    The electromagnetic form factors of the three-nucleon ground state are calculated on the base of an exact solution of the Faddeev equations. In a Hilbert space of nucleons and a possible Δ-isobar the effects of a non-perturbative description of the Δ-isobar on the magnetic form factors are studied. Pure nucleonic current operators with two- and three-particle character can be described in the extended Hilbert space by simpler one-body operators. Additionally nonrelativistic meson-exchange corrections due to π and ρ exchange are calculated consistently with the requirements of current conservation. Further relativistic corrections are estimated on selected examples. The calculations yield a total magnetic contribution of the Δ-isobar which is smaller than hitherto assumed, a static approximation of the Δ propagation is proved as inadmissible and must be rejected. Together with the meson-exchange corrections a well agreement with the experimental data at low momentum transfers results. Especially the magnetic moments and magnetization radii can be explained. For higher momentum transfers the results show the importance of further corrections. The regard of selected relativistic corrections leads to a good description of the experimental magnetic form factors. Also by this way the position of the minimum and the height of the second maximum in the 3 He charge form factor can be explained. The comparison with the latest experimental results reveals furthermore unresolved problems in the description of the 3 H charge form factor. (orig.) [de

  1. One, two or three-nucleon photo- absorption in 3He

    International Nuclear Information System (INIS)

    Tamas, G.

    1986-08-01

    Pion production and photodisintegration of 3 He are studied in the δ resonance region to try to separate the various photon absorption mechanism by one, two or three nucleons. The results are compared to the existing models

  2. Potentials of the inverse scattering problem in the three-nucleon problem

    International Nuclear Information System (INIS)

    Pushkash, A.M.; Simenog, I.V.; Shapoval, D.V.

    1993-01-01

    Possibilities of using the method of the inverse scattering problem for describing simultaneously the two-nucleon and the low-energy three-nucleon data in the S-interaction approximation are examined. 20 refs., 3 figs., 1 tab

  3. Pionic retardation effects in two-pion-exchange three-nucleon forces

    International Nuclear Information System (INIS)

    Coon, S.A.; Friar, J.L.

    1986-01-01

    Those two-pion-exchange three-nucleon forces which arise from nuclear processes that involve only pions and nucleons are calculated. Among the processes which contribute are pion seagulls (e.g., nucleon-antinucleon pair terms) and overlapping, retarded pion exchanges. The resulting potential is shown to be a (v/c) 2 relativistic correction, and satisfies nontrivial constraints from special relativity. The relativistic ambiguities found before in treatments of relativistic corrections to the one-pion-exchange nuclear charge operator and two-body potential are also present in the three-nucleon potential. The resulting three-nucleon force differs from the original Tucson-Melbourne potential only in the presence of several new nonlocal terms, and in the specification of the choice of ambiguity parameters in the latter potential

  4. Pionic retardation effects in two-pion-exchange three-nucleon forces

    Science.gov (United States)

    Coon, S. A.; Friar, J. L.

    1986-09-01

    Those two-pion-exchange three-nucleon forces which arise from nuclear processes that involve only pions and nucleons are calculated. Among the processes which contribute are pion seagulls (e.g., nucleon-antinucleon pair terms) and overlapping, retarded pion exchanges. The resulting potential is shown to be a (v/c)2 relativistic correction, and satisfies nontrivial constraints from special relativity. The relativistic ambiguities found before in treatments of relativistic corrections to the one-pion-exchange nuclear charge operator and two-body potential are also present in the three-nucleon potential. The resulting three-nucleon force differs from the original Tucson-Melbourne potential only in the presence of several new nonlocal terms, and in the specification of the choice of ambiguity parameters in the latter potential.

  5. Pionic retardation effects in two-pion-exchange three-nucleon forces

    Energy Technology Data Exchange (ETDEWEB)

    Coon, S.A.; Friar, J.L.

    1986-09-01

    Those two-pion-exchange three-nucleon forces which arise from nuclear processes that involve only pions and nucleons are calculated. Among the processes which contribute are pion seagulls (e.g., nucleon-antinucleon pair terms) and overlapping, retarded pion exchanges. The resulting potential is shown to be a (v-italic/c-italic)/sup 2/ relativistic correction, and satisfies nontrivial constraints from special relativity. The relativistic ambiguities found before in treatments of relativistic corrections to the one-pion-exchange nuclear charge operator and two-body potential are also present in the three-nucleon potential. The resulting three-nucleon force differs from the original Tucson-Melbourne potential only in the presence of several new nonlocal terms, and in the specification of the choice of ambiguity parameters in the latter potential.

  6. General operator form of the non-local three-nucleon force

    Energy Technology Data Exchange (ETDEWEB)

    Topolnicki, K. [Jagiellonian University, M. Smoluchowski Institute of Physics, Krakow (Poland)

    2017-09-15

    This paper describes a procedure to obtain the general form of the three-nucleon force. The result is an operator form where the momentum space matrix element of the three-nucleon potential is written as a linear combination of 320 isospin-spin-momentum operators and scalar functions of momenta. Any spatial and isospin rotation invariant three-nucleon force can be written in this way and in order for the potential to be Hermitian, symmetric under parity inversion, time reversal and particle exchange, the scalar functions must have definite transformation properties under these discrete operations. A complete list of the isospin-spin-momentum operators and scalar function transformation properties is given. (orig.)

  7. Microscopic nucleon spectral function for finite nuclei featuring two- and three-nucleon short-range correlations: The model versus ab initio calculations for three-nucleon systems

    Science.gov (United States)

    Ciofi degli Atti, Claudio; Mezzetti, Chiara Benedetta; Morita, Hiko

    2017-04-01

    Background: Two-nucleon (2 N ) short-range correlations (SRC) in nuclei have been recently thoroughly investigated, both theoretically and experimentally and the study of three-nucleon (3 N ) SRC, which could provide important information on short-range hadronic structure, is underway. Novel theoretical ideas concerning 2 N and 3 N SRC are put forward in the present paper. Purpose: The general features of a microscopic one-nucleon spectral function which includes the effects of both 2 N and 3 N SRC and its comparison with ab initio spectral functions of the three-nucleon systems are illustrated. Methods: A microscopic and parameter-free one-nucleon spectral function expressed in terms of a convolution integral involving ab initio relative and center-of-mass (c.m.) momentum distributions of a 2 N pair and aimed at describing two- and three-nucleon short-range correlations, is obtained by using: (i) the two-nucleon momentum distributions obtained within ab initio approaches based upon nucleon-nucleon interactions of the Argonne family; (ii) the exact relation between one- and two-nucleon momentum distributions; (iii) the fundamental property of factorization of the nuclear wave function at short internucleon ranges. Results: The comparison between the ab initio spectral function of 3He and the one based upon the convolution integral shows that when the latter contains only two-nucleon short-range correlations the removal energy location of the peaks and the region around them exhibited by the ab initio spectral function are correctly predicted, unlike the case of the high and low removal energy tails; the inclusion of the effects of three-nucleon correlations brings the convolution model spectral function in much better agreement with the ab initio one; it is also found that whereas the three-nucleon short-range correlations dominate the high energy removal energy tail of the spectral function, their effects on the one-nucleon momentum distribution are almost one

  8. A new twist to the long-standing three-nucleon analyzing power puzzle

    Energy Technology Data Exchange (ETDEWEB)

    Neidel, E.M.; Tornow, W.; Gonzalez Trotter, D.E.; Howell, C.R.; Crowell, A.S.; Macri, R.A.; Walter, R.L.; Weisel, G.J.; Esterline, J.; Witala, H.; Crowe, B.J.; Pedroni, R.S.; Markoff, D.M

    2003-01-16

    New results for the neutron-deuteron analyzing power A{sub y}({theta}) at E{sub n}=1.2 and 1.9 MeV and their comparison to proton-deuteron data reveal a sizeable and unexpected difference which increases with decreasing center-of-mass energy. This finding calls for the theoretical treatment of a subtle electromagnetic effect presently not incorporated in rigorous three-nucleon scattering calculations, before it is justified to invoke charge-dependent three-nucleon forces and/or other new physics.

  9. The 20th anniversary of the three-nucleon analyzing power puzzle - a personal recollection

    International Nuclear Information System (INIS)

    Tornow, W. . Author

    2008-01-01

    The history of the three-nucleon analyzing power puzzle is described by an experimentalist who has been collaborating with few-body theoreticians in trying to unravel the physics of this long-standing phenomenon. Although surprising effects have been discovered along the way, the puzzle is still unexplained. Hopefully, some of the long-range three-nucleon force terms predicted by chiral effective field theory in N 3 LO will eventually solve the puzzle. Presented at the 20th Few-Body Conference, Pisa, Italy, 10-14 September 2007. (author)

  10. L-dependence in the 6Li induced three nucleon transfer excitation function

    International Nuclear Information System (INIS)

    Kraus, L.; Linck, I.

    1980-01-01

    The three nucleon transfer reactions induced by 6 Li on 12 C were studied from 5 to 9 MeV/n. The bell-shaped energy variation is used to select cluster states of progressively higher angular momentum. A modification to the Brink semi-classical model equations is proposed in order to reproduce the observed features

  11. Total disintegration of three-nucleon nuclei in charged-pion photo-production

    International Nuclear Information System (INIS)

    Dzhibuti, R.I.; Kezerashvili, R.Y.

    1984-01-01

    The total disintegration of three-nucleon nuclei in charged-pion photo-production is studied within the framework of the microscopic approach based on the method of hyperspherical functions. The initial and final nuclear states are described using the same NN potentials. The differential and total cross sections are calculated using various NN potentials. It is shown that the cross sections are sensitive to the form of the NN interaction and to the final-state interaction of the three nucleons. It is found that the cross section for π - meson production is systematically larger than the cross section for π + meson production. The importance of an experimental investigation of these reactions is shown

  12. Off-energy-shell variations of two-nucleon transition matrix and three-nucleon problem

    International Nuclear Information System (INIS)

    Stingl, M.; Sauer, P.U.

    1975-01-01

    For a schematic three-nucleon problem, approximate analytic expressions are derived for the functional derivatives of measurable three-particle quantities with respect to off-shell variations of the triplet-s two-nucleon transition matrix. Those quantities include neutron-deuteron scattering lengths, trinucleon binding energies, and the 3 He charge form-factor minimum; correlations between off-shell changes in the latter two are discussed. An indication is given how results of this kind may be to decide whether or not a given set of discrepancies between calculated and experimental three-nucleon observables can be reconciled in terms of off-shell variations of a nonretarded hermitean two-nucleon interaction. The treatment is not restricted to special classes of phase-shift equivalent potentials or phase-shift preserving transformations but instead makes use of a systematic parameterization of off-shell variations in terms of symmetric rational approximants of increasing order

  13. Two- and three-nucleon chiral interactions in quantum Monte Carlo calculations for nuclear physics

    Energy Technology Data Exchange (ETDEWEB)

    Lynn, Joel [Institut fuer Kernphysik, Technische Universitaet Darmstadt, 64289 Darmstadt (Germany); Tews, Ingo [Institute for Nuclear Theory, University of Washington, Seattle, Washington 98195 (United States); Carlson, Joseph; Gandolfi, Stefano [Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Gezerlis, Alexandros [Department of Physics, University of Guelph, Guelph, Ontario, N1G 2W1 (Canada); Schmidt, Kevin [Department of Physics, Arizona State University, Tempe, Arizona 85287 (United States); Schwenk, Achim [Institut fuer Kernphysik, Technische Universitaet Darmstadt, 64289 Darmstadt (Germany); ExtreMe Matter Institute EMMI, GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, 64291 Darmstadt (Germany)

    2016-07-01

    I present our recent work on Green's function Monte Carlo calculations of light nuclei using local two- and three-nucleon interactions derived from chiral effective field theory up to next-to-next-to-leading order (N{sup 2}LO). I discuss the choice of observables we make to fit the two low-energy constants which enter in the three-nucleon sector at N{sup 2}LO: the {sup 4}He binding energy and n-α elastic scattering P-wave phase shifts. I then show some results for light nuclei. I also show our results for the energy per neutron in pure neutron matter using the auxiliary-field diffusion Monte Carlo method and discuss regulator choices. Finally I discuss some exciting future projects which are now possible.

  14. Investigation of the Three-Nucleon System Dynamics in the Deuteron-Proton Breakup Reaction

    Science.gov (United States)

    Ciepał, I.; Kłos, B.; Kistryn, St.; Stephan, E.; Biegun, A.; Bodek, K.; Deltuva, A.; Epelbaum, E.; Eslami-Kalantari, M.; Fonseca, A. C.; Golak, J.; Jha, V.; Kalantar-Nayestanaki, N.; Kamada, H.; Khatri, G.; Kirillov, Da.; Kirillov, Di.; Kliczewski, St.; Kozela, A.; Kravcikova, M.; Machner, H.; Magiera, A.; Martinska, G.; Messchendorp, J.; Nogga, A.; Parol, W.; Ramazani-Moghaddam-Arani, A.; Roy, B. J.; Sakai, H.; Sekiguchi, K.; Sitnik, I.; Siudak, R.; Skibiński, R.; Sworst, R.; Urban, J.; Witała, H.; Zejma, J.

    2014-08-01

    Precise and large sets of cross section, vector A x , A y and tensor A xx , A xy , A yy analyzing power data for the 1 H( d, pp) n breakup reactions were measured at 100 and 130 MeV deuteron beam energies with the SALAD and BINA detectors at KVI and the Germanium Wall setup at FZ-Jülich. Results are compared with various theoretical approaches which model the three-nucleon system dynamics. The cross section data reveal a sizable three-nucleon force (3NF) and Coulomb force influence. In case of the analyzing powers very low sensitivity to these effects was found and the data are well describe by 2N models only. For A xy at 130 MeV, serious disagreements were observed when 3NF models are included in the calculations.

  15. Three-nucleon system dynamics studied via deuteron-proton breakup

    International Nuclear Information System (INIS)

    Kistryn, S.

    2011-01-01

    Nucleon-nucleon (NN) interaction is a basis for vast fields of fundamental nuclear physics and its application, therefore a detailed knowledge of the dynamics of few-nucleon systems has been a subject of intensive quest over several decades. Modern NN potential models can be probed quantitatively in the three-nucleon environment by comparing predictions based on rigorous solutions of the Faddeev equations with the measured observables. Proper description of the experimental data can be achieved only if the dynamical models include subtle effects of suppressed degrees of freedom, effectively introduced by means of genuine three-nucleon forces. A large set of high precision, exclusive cross-section data for the "1H(d,pp)n breakup reaction at 130 MeV, acquired in a first new-generation experiment at KVI Groningen, contributes significantly to constrain the physical assumptions underlying the theoretical interaction models. Comparison of nearly 1800 cross-section data points with the predictions using nuclear interactions generated in various ways, allowed to establish for the first time a clear evidence of importance of the three-nucleon forces in the breakup process. Moreover, the results, supplemented by a set of cross-sections from another dedicated experiment at FZ Juelich, confirmed predictions of sizable Coulomb force influences in this reaction. Following further, comparably rich and precise data sets, encompassing also polarization observables, will form a database to validate the theoretical models of few-nucleon system dynamics. (author)

  16. Study of three nucleon mechanisms in the photodisintegration of 3 He

    International Nuclear Information System (INIS)

    Audit, G.; D'Hose, N.; Isbert, V.; Kerhoas, S.; Laget, J.M.; Mac Cormick, M.; Murphy, L.Y.; Tamas, G.; Panzeri, A.; Pinelli, T.; Ahrens, J.; Annand, J.R.M.; Crawford, R.; Hall, S.J.; Kellie, J.D.; Murphy, L.Y.

    1996-01-01

    The cross section of the 3 He (γ,pp)n reaction has been measured for the first time over a wide photon energy and proton angular range (200 MeV ≤ Eγ ≤ 800 MeV; 20 deg ≤ v lab p ≤ 160 deg) using the large acceptance detector DAPHNE at the tagged photon facility of the microtron in Mainz. The wide kinematical coverage of the measurement has allowed a detailed analysis of three nucleon absorption mechanisms. A model developed by Laget explains the main characteristics of the data in the Δ resonance region. (authors)

  17. Three-Nucleon Force Effects in p-"3H and n-"3He Scattering

    International Nuclear Information System (INIS)

    Viviani, M.; Kievsky, A.; Girlanda, L.; Marcucci, L. E.

    2017-01-01

    We present a preliminary study of the effect of a three-nucleon force (3NF) in p-"3H and n-"3 He scattering at low energies. The used 3NF is derived from effective field theory at next-to-next-to-leading order. The four-nucleon scattering observables are calculated using the Kohn variational principle and the hyperspherical harmonics technique and the results are compared with available experimental data. We have found that the effect of introducing this type of 3NF is tiny, and sometimes worsens the agreement with the experimental data. (author)

  18. Studies of the Three-Nucleon System Dynamics in the Deuteron-Proton Breakup Reaction

    Science.gov (United States)

    Ciepał, I.; Kłos, B.; Stephan, E.; Kistryn, St.; Biegun, A.; Bodek, K.; Deltuva, A.; Epelbaum, E.; Eslami-Kalantari, M.; Fonseca, A. C.; Golak, J.; Jha, V.; Kalantar-Nayestanaki, N.; Kamada, H.; Khatri, G.; Kirillov, Da.; Kirillov, Di.; Kliczewski, St.; Kozela, A.; Kravcikova, M.; Machner, H.; Magiera, A.; Martinska, G.; Messchendorp, J.; Nogga, A.; Parol, W.; Ramazani-Moghaddam-Arani, A.; Roy, B. J.; Sakai, H.; Sekiguchi, K.; Sitnik, I.; Siudak, R.; Skibiński, R.; Sworst, R.; Urban, J.; Witała, H.; Zejma, J.

    2014-03-01

    One of the most important goals of modern nuclear physics is to contruct nuclear force model which properly describes the experimental data. To develop and test predictions of current models the breakup 1H(overrightarrow d, pp)n reaction was investigated experimentally at 100 and 130 MeV deuteron beam energies. Rich set of data for cross section, vector and tensor analyzing powers was obtained with the use of the SALAD and BINA detectors at KVI and Germanium Wall setup at FZ-Jülich. Results are compared with various theoretical approaches which describe the three-nucleon (3N) system dynamics. For correct description of the cross section data both, three-nucleon force (3NF) and Coulomb force, have to be included into calculations and influence of those ingredients is seizable at specific parts of the phase space. In case of the vector analyzing powers very low sensitivity to any effects beyond nucleon-nucleon interaction was found. At 130 MeV, the Axy data are not correctly described when 3NF models are included into calculations.

  19. Probing the three-nucleon force using nucleon-deuteron breakup reactions

    International Nuclear Information System (INIS)

    Howell, C.R.; Lambert, J.M.; Witala, H.

    1995-01-01

    Results of our recent kinematically complete cross-section measurements of the space-star and coplanar-star configurations in n-d breakup at 13.0 MeV are reported. The experimental setup and details of the analysis are described. The new data for the space-star configuration are in good agreement with previous n-d data but differ significantly from both ''exact'' n-d calculations and p-d data. In contrast, the new coplanar-star data are in fair agreement with the calculations but are in gross disagreement with previous n-d data. The implications of these data for three-nucleon forces are discussed. (orig.)

  20. Probing the three-nucleon force using nucleon-deuteron breakup reactions

    Energy Technology Data Exchange (ETDEWEB)

    Howell, C.R. [Duke Univ., Durham, NC (United States). Dept. of Physics; Setze, H.R. [Duke Univ., Durham, NC (United States). Dept. of Physics; Braun, R.T. [Duke Univ., Durham, NC (United States). Dept. of Physics; Gonzalez Trotter, D.E. [Duke Univ., Durham, NC (United States). Dept. of Physics; Hussein, A.H. [Duke Univ., Durham, NC (United States). Dept. of Physics; Roper, C.D. [Duke Univ., Durham, NC (United States). Dept. of Physics; Salinas, F. [Duke Univ., Durham, NC (United States). Dept. of Physics; Slaus, I. [Duke Univ., Durham, NC (United States). Dept. of Physics; Tornow, W. [Duke Univ., Durham, NC (United States). Dept. of Physics; Vlahovic, B. [Duke Univ., Durham, NC (United States). Dept. of Physics; Walter, R.L. [Duke Univ., Durham, NC (United States). Dept. of Physics; Mertens, G. [Tuebingen Univ. (Germany); Lambert, J.M. [Department of Physics, Georgetown University, Washington, DC 20057 (United States); Witala, H. [Institute of Physics, Jagellonian University, Reymonta 4, PL-30059 Cracow (Poland)

    1995-05-01

    Results of our recent kinematically complete cross-section measurements of the space-star and coplanar-star configurations in n-d breakup at 13.0 MeV are reported. The experimental setup and details of the analysis are described. The new data for the space-star configuration are in good agreement with previous n-d data but differ significantly from both ``exact`` n-d calculations and p-d data. In contrast, the new coplanar-star data are in fair agreement with the calculations but are in gross disagreement with previous n-d data. The implications of these data for three-nucleon forces are discussed. (orig.).

  1. The effect of including tensor forces in nucleon-nucleon interaction on three-nucleon binding energy

    International Nuclear Information System (INIS)

    Osman, A.; Ramadan, S.

    1986-01-01

    Separable two-body interactions are used in considering the three-nucleon problem. The nucleon-nucleon potentials are taken to include attraction and repulsion as well as tensor forces. The separable approximation is used in order to investigate the effect of the tensor forces. The separable expansion is introduced in the three-nucleon problem, by which the Faddeev equations are reduced to a well-behaved set of coupled integral equations. Numerical calculations are carried out for the obtained integral equations using potential functions of the Yamaguchi, Gaussian, Takabin, Mongan and Reid forms. The present calculated values of the binding energies of the 3 H and 3 He nuclei are in good agreement with the experimental values. The effect of including the tensor forces in the nucleon-nucleon interactions is found to improve the three-nucleon binding energy by about 4.490% to 8.324%. 37 refs., 2 tabs. (author)

  2. Analysis of Three-Nucleon Forces Effects in the A = 3 System

    International Nuclear Information System (INIS)

    Kievsky, A.

    2011-01-01

    Using modern nucleon-nucleon interactions in the description of the A = 3, 4 nuclear systems the χ 2 per datum results to be much bigger than one. In particular it is not possible to reproduce the three- and four-nucleon binding energies and the n .d scattering length simultaneously. This is one manifestation of the necessity of including a three-nucleon force in the nuclear Hamiltonian. In this paper we perform an analysis of some, widely used, three-nucleon force models.We analyze their capability to describe the aforementioned quantities and, to improve their description, we propose modifications in the parametrization of the models. The effects of these new parametrizations are studied in some polarization observables at low energies. Due to the fact that some of the widely used TNF models do not reproduce simultaneously the triton and 4 He binding energies and the n -d doublet scattering length, possible modifications of their parametrizations have been analyzed. To this end we have used the AV18 as the reference NN interaction and we have analyze possible modifications of the URIX model. We have modified the regularization of the profile functions Y (r ) and T (r ) at the origin and we have introduced the Z 0 (r ) function in the central repulsive E-term. We have used one-parameter functions that have been chosen to match the short-range behavior of the corresponding functions in the N2LOL model. Furthermore the strengths of the b-, d-terms and E-terms have been fixed to reproduce the triton binding energy and 2 a nd . Then the predictions for some selected scattering observables in p - d scattering at 3 MeV have been compared to the results of the original model and the experimental data. We can observe that the description using the new parametrizations has the same quality of the original model. However, with the proposed parametrizations, the AV18+URIX model describes correctly B( 3 H) and 2 a nd . This analysis can be consider as a preliminary step in a

  3. Few-Nucleon Research at TUNL: Probing Two- and Three-Nucleon Interactions with Neutrons

    Science.gov (United States)

    Howell, C. R.; Tornow, W.; Witała, H.

    2016-03-01

    The central goal of few-nucleon research at the Triangle Universities Nuclear Laboratory (TUNL) is to perform measurements that contribute to advancing ab-initio calculations of nuclear structure and reactions. The program aims include evaluating theoretical treatments of few-nucleon reaction dynamics through strategically comparing theory predictions to data, determining properties of the neutron-neutron interaction that are not accessible in two-nucleon reactions, and searching for evidence of longrange features of three-nucleon interactions, e.g., spin and isospin dependence. This paper will review studies of three- and four-nucleon systems at TUNL conducted using unpolarized and polarized neutron beams. Measurements of neutron-induced reactions performed by groups at TUNL over the last six years are described in comparison with theory predictions. The results are discussed in the context of the program goals stated above. Measurements of vector analyzing powers for elastic scattering in A=3 and A=4 systems, differential cross sections for neutron-deuteron elastic scattering and neutrondeuteron breakup in several final-state configurations are described. The findings from these studies and plans for the coming three years are presented in the context of worldwide activities in this front, in particular, research presented in this session.

  4. Di-nucleon structures in homogeneous nuclear matter based on two- and three-nucleon interactions

    Energy Technology Data Exchange (ETDEWEB)

    Arellano, Hugo F. [University of Chile, Department of Physics - FCFM, Santiago (Chile); CEA, DAM, DIF, Arpajon (France); Isaule, Felipe [University of Chile, Department of Physics - FCFM, Santiago (Chile); Rios, Arnau [University of Surrey, Department of Physics, Faculty of Engineering and Physical Sciences, Guildford (United Kingdom)

    2016-09-15

    We investigate homogeneous nuclear matter within the Brueckner-Hartree-Fock (BHF) approach in the limits of isospin-symmetric nuclear matter (SNM) as well as pure neutron matter at zero temperature. The study is based on realistic representations of the internucleon interaction as given by Argonne v{sub 18}, Paris, Nijmegen I and II potentials, in addition to chiral N{sup 3}LO interactions, including three-nucleon forces up to N{sup 2}LO. Particular attention is paid to the presence of di-nucleon bound states structures in {sup 1}S{sub 0} and {sup 3}SD{sub 1} channels, whose explicit account becomes crucial for the stability of self-consistent solutions at low densities. A characterization of these solutions and associated bound states is discussed. We confirm that coexisting BHF single-particle solutions in SNM, at Fermi momenta in the range 0.13-0.3 fm{sup -1}, is a robust feature under the choice of realistic internucleon potentials. (orig.)

  5. Few-Nucleon Research at TUNL: Probing Two- and Three-Nucleon Interactions with Neutrons

    Directory of Open Access Journals (Sweden)

    Howell C.R.

    2016-01-01

    Full Text Available The central goal of few-nucleon research at the Triangle Universities Nuclear Laboratory (TUNL is to perform measurements that contribute to advancing ab-initio calculations of nuclear structure and reactions. The program aims include evaluating theoretical treatments of few-nucleon reaction dynamics through strategically comparing theory predictions to data, determining properties of the neutron-neutron interaction that are not accessible in two-nucleon reactions, and searching for evidence of longrange features of three-nucleon interactions, e.g., spin and isospin dependence. This paper will review studies of three- and four-nucleon systems at TUNL conducted using unpolarized and polarized neutron beams. Measurements of neutron-induced reactions performed by groups at TUNL over the last six years are described in comparison with theory predictions. The results are discussed in the context of the program goals stated above. Measurements of vector analyzing powers for elastic scattering in A=3 and A=4 systems, differential cross sections for neutron-deuteron elastic scattering and neutrondeuteron breakup in several final-state configurations are described. The findings from these studies and plans for the coming three years are presented in the context of worldwide activities in this front, in particular, research presented in this session.

  6. Studies of the three-nucleon system dynamics : Cross sections of the deuteron-proton breakup at 130 MeV

    NARCIS (Netherlands)

    Kistryn, St.; Stephan, E.; Kalantar-Nayestanaki, N.; Biegun, A.; Bodek, K.; Ciepal, I.; Deltuva, A.; Epelbaum, E.; Fonseca, A. C.; Gloeckle, W.; Golak, J.; Kamada, H.; Kis, M.; Klos, B.; Kozela, A.; Nogga, A.; Mahjour-Shafiei, M.; Micherdzinska, A.; Sauer, P. U.; Skibinski, R.; Sworst, R.; Witala, H.; Zejma, J.; Zipper, W.

    2008-01-01

    The three-nucleon system is the simplest non-trivial testing ground in which the quality of modern nucleon-nucleon interaction models, as well as additional dynamical ingredients referred to as three-nucleon forces, can be probed quantitatively by means of a rigorous technique of solving the Faddeev

  7. Three-nucleon force contribution in the distorted-wave theory of (d ,p ) reactions

    Science.gov (United States)

    Timofeyuk, N. K.

    2018-05-01

    The distorted-wave theory of A (d ,p )B reactions, widely used to analyze experimental data, is based on a Hamiltonian that includes only two-nucleon interactions. However, numerous studies of few-nucleon systems and many modern developments in nuclear structure theory show the importance of the three-nucleon (3 N ) force. The purpose of this paper is to study the contribution of the 3 N force of the simplest possible form to the A (d ,p )B reaction amplitude. This contribution is given by a new term that accounts for the interaction of the neutron and proton in the incoming deuteron with one of the target nucleons. This term involves a new type of nuclear matrix elements containing an infinite number of target excitations in addition to the main part associated with the traditional overlap function between A and B . The nuclear matrix elements are calculated for double-closed shell targets within a mean field theory where target excitations are shown to be equivalent to exchanges between valence and core nucleons. These matrix elements can be readily incorporated into available reaction codes if the 3 N interaction has a spin-independent zero-range form. Distorted-wave calculations are presented for a contact 3 N force with the volume integral fixed by the chiral effective field theory at the next-to-next-to-leading order. For this particular choice, the 3 N contribution is noticeable, especially at high deuteron incident energies. No 3 N effects are seen for incident energies below the Coulomb barrier. The finite range can significantly affect the 3 N contribution to the (d ,p ) cross sections. Finite-range studies require new formal developments and, therefore, their contribution is preliminarily assessed within the plane-wave Born approximation, together with sensitivity to the choice of the deuteron model.

  8. Three-nucleon transfer reactions and cluster structure in the A = 15 to A = 19 nuclei

    International Nuclear Information System (INIS)

    Martz, L.M.

    1978-01-01

    The ( 6 Li,t) and ( 6 Li, 3 He) reactions were studied on targets of 12 C, 13 C, 14 N, 15 N, and 16 O at E/sub Li/ approx. = 44 MeV and theta/sub lab/ approx. = 15 0 . A preferential population of final states was exhibited in spectra for the A = 15 to A = 19 nuclei. The strong forward peaking of angular distributions in the 13 C( 6 Li,t) 16 O and 13 C( 6 Li, 3 He) 16 N reactions can be reproduced by DWBA calculations but not by the Hauser-Feshbach model. Such indications of a primarily direct mechanism at forward angles suggest use of these three-nucleon-transfer reactions to identify candidates for 3p-nh states. A comparison with other multinucleon transfer data, e.g., those from ( 7 Li,α) and ( 7 Li,t) reactions on 13 C and 15 N targets, further tests dominant particle-hole configurations. The relationship between ( 6 Li,t) and ( 6 Li, 3 He) spectra reveals analog states, notably T = 1, T/sub z/ = 0 levels at high excitation in 16 O. Nuclear theory is used to investigate the role of triton clustering in such structure. The 2N + L = 6 band predicted by a folded-potential model of 18 O = 15 N + t shows an underlying correspondence to the experimental levels in triton-transfer data. Triton spectroscopic factors calculated from the SU(3) shell model further suggest the broad influence of clustering phenomena in this mass region. Experimental evidence of systematic behavior in the triton binding energies of proposed p/sup -n/(sd) 3 configurations was found

  9. Measurements of the n->d scattering at 250 MeV and three-nucleon forces

    International Nuclear Information System (INIS)

    Maeda, Y.; Sakai, H.; Fujita, K.; Hatano, M.; Kamiya, J.; Kawabata, T.; Kuboki, H.; Hatanaka, K.; Okamura, H.; Saito, T.; Sakemi, Y.; Sasano, M.; Sekiguchi, K.; Shimizu, Y.; Suda, K.; Tameshige, Y.; Tamii, A.; Wakasa, T.; Yako, K.; Greenfield, M.B.; Kamada, H.; Witala, H.

    2007-01-01

    The differential cross sections and the vector analyzing powers for the nd elastic scattering at E n = 250 MeV have been measured for the study of the three-nucleon force (3NF) effects in the Coulomb-free system. To cover a wide angular region, the experiments were performed by using two different methods at the (n, p) facility and at the NTOF facility which constructed at the Research Center for Nuclear Physics (RCNP). The results were compared with theoretical predictions of the Faddeev calculations based on the modern nucleon-nucleon (NN) forces with the three-nucleon force (3NF). The inclusion of 3NFs leads to a good description of the cross section except for the backward angles. The results were also compared with the theoretical predictions with relativistic corrections. The direct data-to-data comparison of the cross sections of the nd and pd was performed

  10. Chiral three-nucleon forces and the evolution of correlations along the oxygen isotopic chain

    Science.gov (United States)

    Cipollone, A.; Barbieri, C.; Navrátil, P.

    2015-07-01

    Background: Three-nucleon forces (3NFs) have nontrivial implications on the evolution of correlations at extreme proton-neutron asymmetries. Recent ab initio calculations show that leading-order chiral interactions are crucial to obtain the correct binding energies and neutron driplines along the O, N, and F chains [A. Cipollone, C. Barbieri, and P. Navrátil, Phys. Rev. Lett. 111, 062501 (2013), 10.1103/PhysRevLett.111.062501]. Purpose: Here we discuss the impact of 3NFs along the oxygen chain for other quantities of interest, such has the spectral distribution for attachment and removal of a nucleon, spectroscopic factors, and radii. The objective is to better delineate the general effects of 3NFs on nuclear correlations. Methods: We employ self-consistent Green's function (SCGF) theory which allows a comprehensive calculation of the single-particle spectral function. For the closed subshell isotopes, 14O, 16O, 22O, 24O, and 28O, we perform calculations with the Dyson-ADC(3) method, which is fully nonperturbative and is the state of the art for both nuclear physics and quantum chemistry applications. The remaining open-shell isotopes are studied using the newly developed Gorkov-SCGF formalism up to second order. Results: We produce complete plots for the spectral distributions. The spectroscopic factors for the dominant quasiparticle peaks are found to depend very little on the leading-order (NNLO) chiral 3NFs. The latter have small impact on the calculated matter radii, which, however, are consistently obtained smaller than experiment. Similarly, single-particle spectra tend to be too spread with respect to the experiment. This effect might hinder, to some extent, the onset of correlations and screen the quenching of calculated spectroscopic factors. The most important effect of 3NFs is thus the fine tuning of the energies for the dominant quasiparticle states, which governs the shell evolution and the position of driplines. Conclusions: Although present chiral

  11. The effect of higher order different meson exchange nucleon-nucleon interactions on the three-nucleon binding energy coupling problem

    International Nuclear Information System (INIS)

    Osman, A.; Ramadan, S.

    1989-01-01

    Faddeev equations of bound three-nucleon system are presented as a set of integral equations. To solve them, a sutable form of the nucleon-nucleon interactions is used: with the exchange of a scalar meson, a pseudoscalar meson and a massless vector meson. Higher orders of these different meson exchanges in the nucleon-nucleon interactions have been taken into account. With these nuclear forces and nucleon-nucleon interactions, the three-nucleon binding energy is calculated by solving the Faddeev integral equations. The obtained value of the three-nucleon binding energy is 8.441 MeV. The inclusion of the higher order terms of the different meson exchange in the nuclear nucleon-nucleon interaction is found to affect the three-nucleon binding by about 3.92%. 3 figs., 16 refs

  12. Weak interaction in a three nucleon system: search for an asymmetry in radiative capture n-d

    International Nuclear Information System (INIS)

    Avenier, M.

    1982-01-01

    Experimental determination of the weak interaction rate in a three nucleon neutron-deuteron system: this weak interaction is observed through pseudoscalar parameters such as the asymetric angular distribution of the capture photon in relation with the system polarization. Orientation of the system is achieved by use of a polarized cold neutron beam. This phenomena is explained as a result of weak coupling between nucleons and mesons. Measurements of the gamma asymmetries observed when tests are conducted with or without heavy water and effects of depolarization are discussed [fr

  13. Symbolic computation of the Hartree-Fock energy from a chiral EFT three-nucleon interaction at N2LO

    International Nuclear Information System (INIS)

    Gebremariam, B.; Bogner, S.K.; Duguet, T.

    2010-01-01

    We present the first of a two-part Mathematica notebook collection that implements a symbolic approach for the application of the density matrix expansion (DME) to the Hartree-Fock (HF) energy from a chiral effective field theory (EFT) three-nucleon interaction at N 2 LO. The final output from the notebooks is a Skyrme-like energy density functional that provides a quasi-local approximation to the non-local HF energy. In this paper, we discuss the derivation of the HF energy and its simplification in terms of the scalar/vector-isoscalar/isovector parts of the one-body density matrix. Furthermore, a set of steps is described and illustrated on how to extend the approach to other three-nucleon interactions. Program summary: Program title: SymbHFNNN; Catalogue identifier: AEGC v 1 0 ; Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEGC_v1_0.html; Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland; Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html; No. of lines in distributed program, including test data, etc.: 96 666; No. of bytes in distributed program, including test data, etc.: 378 083; Distribution format: tar.gz; Programming language: Mathematica 7.1; Computer: Any computer running Mathematica 6.0 and later versions; Operating system: Windows Xp, Linux/Unix; RAM: 256 Mb; Classification: 5, 17.16, 17.22; Nature of problem: The calculation of the HF energy from the chiral EFT three-nucleon interaction at N 2 LO involves tremendous spin-isospin algebra. The problem is compounded by the need to eventually obtain a quasi-local approximation to the HF energy, which requires the HF energy to be expressed in terms of scalar/vector-isoscalar/isovector parts of the one-body density matrix. The Mathematica notebooks discussed in this paper solve the latter issue. Solution method: The HF energy from the chiral EFT three-nucleon interaction at N 2 LO is cast into a form suitable for an automatic

  14. Unified description of ^{6}Li structure and deuterium-^{4}He dynamics with chiral two- and three-nucleon forces.

    Science.gov (United States)

    Hupin, Guillaume; Quaglioni, Sofia; Navrátil, Petr

    2015-05-29

    We provide a unified ab initio description of the ^{6}Li ground state and elastic scattering of deuterium (d) on ^{4}He (α) using two- and three-nucleon forces from chiral effective field theory. We analyze the influence of the three-nucleon force and reveal the role of continuum degrees of freedom in shaping the low-lying spectrum of ^{6}Li. The calculation reproduces the empirical binding energy of ^{6}Li, yielding an asymptotic D- to S-state ratio of the ^{6}Li wave function in the d+α configuration of -0.027, in agreement with a determination from ^{6}Li-^{4}He elastic scattering, but overestimates the excitation energy of the 3^{+} state by 350 keV. The bulk of the computed differential cross section is in good agreement with data. These results endorse the application of the present approach to the evaluation of the ^{2}H(α,γ)^{6}Li radiative capture, responsible for the big-bang nucleosynthesis of ^{6}Li.

  15. Title IX Resource Guide

    Science.gov (United States)

    Office for Civil Rights, US Department of Education, 2015

    2015-01-01

    Title IX of the Education Amendments of 1972 (Title IX) prohibits discrimination based on sex in education programs and activities in federally funded schools at all levels. If any part of a school district or college receives any Federal funds for any purpose, all of the operations of the district or college are covered by Title IX. The essence…

  16. Three-body forces in nuclear matter from intermediate Δ-states in three-nucleon clusters

    International Nuclear Information System (INIS)

    Kouki, T.; Smulter, L.E.W.; Green, A.M.

    1976-10-01

    The three-body force contribution in nuclear matter is treated as a three-nucleon cluster, in which one of the nucleons becomes, in an intermediate state, a Δ(1236). All exchange diagrams are calculated and found to significantly reduce the energy per particle from the direct graph. This is contrary to earlier estimates of the exchanges, using more approximate approaches. The resulting attractive contribution is rather small, -1.1 MeV at ksub(F)=1.4 fm -1 , but the roughly linear density dependence has a crucial effect on the saturation properties. The sensitivity of the results to the correlations used, and to the two-body force spin structure, is displayed. The energy per particle from clusters with three intermediate Δ's is also estimated. (author)

  17. Δ effects in pion-nucleon scattering and the strength of the two-pion-exchange three-nucleon interaction

    International Nuclear Information System (INIS)

    Pandharipande, V.R.; Phillips, D.R.; Kolck, U. van

    2005-01-01

    We consider the relationship between p-wave πN scattering and the strength of the p-wave two-pion-exchange three-nucleon interaction (TPE3NI). We explain why effective theories that do not contain the Delta resonance as an explicit degree of freedom tend to overestimate the strength of the TPE3NI. The overestimation can be remedied by higher-order terms in these 'Delta-less' theories, but such terms are not yet included in state-of-the-art chiral effective field theory calculations of the nuclear force. This suggests that these calculations can predict the strength of the TPE3NI only to an accuracy of ±25%

  18. Cross Sections of the Deuteron-Proton Breakup at 130 MeV : A Probe of Three-Nucleon System Dynamics

    NARCIS (Netherlands)

    Kistryn, St.; Stephan, E.; Kalantar-Nayestanaki, N.; Biegun, A.; Bodek, K.; Ciepal, I.; Deltuva, A.; Eslami-Kalantari, M.; Fonseca, A. C.; Kis, M.; Klos, B.; Kozela, A.; Mahjour-Shafiei, M.; Messchendorp, J.; Micherdzinska, A.; Parol, W.; Ramazani-Moghaddam-Arani, A.; Sworst, R.; Zejma, J.

    Three-nucleon system dynamics can be investigated quantitatively by comparing observables calculated with the use of Faddeev equations with results of precise measurements. Proper description of the experimental data can be achieved only if the dynamical models include, in addition to the

  19. /sup 58,60,62/Ni (. cap alpha. ,p) three--nucleon transfer reactions and. cap alpha. optical potential ambiguities

    Energy Technology Data Exchange (ETDEWEB)

    Yuanda, Wang; Xiuming, Bao; Zhiqiang, Mao; Rongfang, Yuan; Keling, Wen; Binyin, Huang; Zhifu, Wang; Shuming, Li; Jianan, Wang; Zuxun, Sun; others, and

    1985-11-01

    The differential cross sections are measured using 26.0 MeV ..cap alpha.. particle for /sup 58,62/Ni(..cap alpha.., ..cap alpha..) /sup 58,62/Ni and /sup 58,62/Ni(..cap alpha..,p) /sup 61,65/Cu reactions as well as 25.4 MeV ..cap alpha.. particle for /sup 60/Ni(..cap alpha.., ..cap alpha..)/sup 69/Ni and /sup 60/Ni(..cap alpha.., p)/sup 63/Cu reactions. Consistent calculations with optical model and ZR DWBA are made for (..cap alpha.., ..cap alpha..) and (..cap alpha.., p) reactions by using of single, two, three and four nucleon optical potential parameters. For elastic scattering due to the ..cap alpha.. optical potential ambiguities, all the above optical potential can reproduce the experimental angular distributions. However, the single, two and three nucleon potential, including the Baird's mass systematics and the Chang's energy systematics of ..cap alpha.. potentials, obviously can not provide a reasonable fitting with the (..cap alpha..,p) reaction experimental data. Only the results from the four nucleon potential is in good agreement with the (..cap alpha..,p) reaction experimental data. This reveals that in the ..cap alpha..-particle induced transfer reactions, the real depth of the ..cap alpha..-nucleus optical potential should be rather deep.

  20. Three-body dynamics in one dimension: a test model for the three-nucleon system with irreducible pionic diagrams

    International Nuclear Information System (INIS)

    Melde, T.; Canton, L.; Svenne, J.P.

    2002-01-01

    We formulate the three-body problem in one dimension in terms of the (Faddeev-type) integral equation approach. As an application, we develop a spinless, one-dimensional (1-D) model that mimics three-nucleon dynamics in one dimension. Using simple two-body potentials that reproduce the deuteron binding, we obtain that the three-body system binds at about 7.5 MeV. We then consider two types of residual pionic corrections in the dynamical equation; one related to the 2π-exchange three-body diagram, the other to the 1π-exchange three-body diagram. We find that the first contribution can produce an additional binding effect of about 0.9 MeV. The second term produces smaller binding effects, which are, however, dependent on the uncertainty in the off-shell extrapolation of the two-body t-matrix. This presents interesting analogies with what occurs in three dimensions. The paper also discusses the general three-particle quantum scattering problem, for motion restricted to the fall line. (author)

  1. Effects of chiral three-nucleon forces on 4He-nucleus scattering in a wide range of incident energies

    Science.gov (United States)

    Toyokawa, Masakazu; Yahiro, Masanobu; Matsumoto, Takuma; Kohno, Michio

    2018-02-01

    An important current subject is to clarify the properties of chiral three-nucleon forces (3NFs) not only in nuclear matter but also in scattering between finite-size nuclei. Particularly for elastic scattering, this study has just started and the properties are not understood for a wide range of incident energies (E_in). We investigate basic properties of chiral 3NFs in nuclear matter with positive energies by using the Brueckner-Hartree-Fock method with chiral two-nucleon forces at N3LO and 3NFs at NNLO, and analyze the effects of chiral 3NFs on 4He elastic scattering from targets ^{208}Pb, ^{58}Ni, and ^{40}Ca over a wide range of 30 ≲ E_in/A_P ≲ 200 MeV by using the g-matrix folding model, where A_P is the mass number of the projectile. In symmetric nuclear matter with positive energies, chiral 3NFs make the single-particle potential less attractive and more absorptive. The effects mainly come from the Fujita-Miyazawa 2π-exchange 3NF and become slightly larger as E_in increases. These effects persist in the optical potentials of 4He scattering. As for the differential cross sections of 4He scattering, chiral-3NF effects are large for E_in/A_P ≳ 60 MeV and improve the agreement of the theoretical results with the measured ones. Particularly for E_in/A_P ≳ 100 MeV, the folding model reproduces measured differential cross sections pretty well. Cutoff (Λ) dependence is investigated for both nuclear matter and 4He scattering by considering two cases of Λ=450 and 550 MeV. The uncertainty coming from the dependence is smaller than chiral-3NF effects even at E_in/A_P=175 MeV.

  2. Factor IX assay

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003679.htm Factor IX assay To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  3. Improved proton-deuteron phase-shift analysis above the deuteron breakup threshold and the three-nucleon analyzing-power puzzle

    International Nuclear Information System (INIS)

    Tornow, W.; Kievsky, A.; Witala, H.

    2002-01-01

    Using the existing high-accuracy data for proton-deuteron and deuteron-proton elastic scattering, a phase-shift analysis has been performed in the laboratory proton energy range from E p = 4 to 10 MeV The AV 18-based proton-deuteron phase shifts were used as starting values in the phase-shift search procedure. The low-partial wave phase shifts, especially the 4 P j phase shifts have been determined very precisely, thus providing valuable guidance for theoretical approaches to tackle the quest for a successful description of three-nucleon bound-state and continuum observables in a more efficient and consistent way. Furthermore, it was found that the 4 P 1/2 phase shift and the mixing parameter ε 3/2 - determined in the present analysis cannot be generated by 3 P j nucleon-nucleon interactions which are consistent with two-nucleon analyzing power data. Therefore, three-nucleon forces must play an essential role in resolving the long-standing three-nucleon analyzing-power puzzle. Refs. 44 (author)

  4. Improved proton-deuteron phase-shift analysis above the deuteron breakup threshold and the three-nucleon analyzing-power puzzle

    CERN Document Server

    Tornow, W; Witala, H

    2002-01-01

    Using the existing high-accuracy data for proton-deuteron and deuteron-proton elastic scattering, a phase-shift analysis has been performed in the laboratory proton energy range from E sub p = 4 to 10 MeV The AV 18-based proton-deuteron phase shifts were used as starting values in the phase-shift search procedure. The low-partial wave phase shifts, especially the sup 4 P sub j phase shifts have been determined very precisely, thus providing valuable guidance for theoretical approaches to tackle the quest for a successful description of three-nucleon bound-state and continuum observables in a more efficient and consistent way. Furthermore, it was found that the sup 4 P sub 1 sub / sub 2 phase shift and the mixing parameter epsilon sub 3 sub / sub 2 sub sup - determined in the present analysis cannot be generated by sup 3 P sub j nucleon-nucleon interactions which are consistent with two-nucleon analyzing power data. Therefore, three-nucleon forces must play an essential role in resolving the long-standing thre...

  5. Violencia urbana nuevos escenarios

    Directory of Open Access Journals (Sweden)

    Fernando Carrión M.

    2015-01-01

    Full Text Available La crisis económica generaliza la inseguridad social y económica, contribuye a reducir los mecanismos de representación, a limitar los espacios de solución de los conflictos, a mercantilizar las relaciones sociales y a restringir las manifestaciones culturales de los ciudadanos. De allí que la restricción del origen y fuente de la ciudadanía lleve al incremento de la violencia urbana e inseguridad ciudadana, y a la reducción de la calidad de vida de la población.

  6. La pobreza urbana en México

    OpenAIRE

    Brambila, Carlos

    2006-01-01

    El propósito del capítulo es entender la naturaleza de la pobreza urbana en México. Un mejor entendimiento de la pobreza urbana permitirá analizar y discutir las implicaciones metodológicas de las diferencias entre los indicadores de la pobreza urbana y la rural.

  7. Systematic study of three-nucleon force effects in the cross section of the deuteron-proton breakup at 130 MeV

    International Nuclear Information System (INIS)

    St. Kistryn; E. Stephan; A. Biegun; K. Bodek; A. Deltuva; E. Epelbaum; K. Ermisch; W. Gloeckle; J. Golak; N. Kalantar-Nayestanaki; H. Kamada; M. Kis; B. Klos; A. Kozela; J. Kuros-Zolnierczuk; M. Mahjour-Shafiei; U.-G. Meissner; A. Micherdzinska; A. Nogga; P. U. Sauer; R. Skibinski; R. Sworst; H. Witala; J. Zejma; W. Zipper

    2005-01-01

    High precision cross-section data of the deuteron-proton breakup reaction at 130 MeV are presented for 72 kinematically complete configurations. The data cover a large region of the available phase space, divided into a systematic grid of kinematical variables. They are compared with theoretical predictions, in which the full dynamics of the three-nucleon (3N) system is obtained in three different ways: realistic nucleon-nucleon (NN) potentials are combined with model 3N forces (3NF's) or with an effective 3NF resulting from explicit treatment of the Delta-isobar excitation. Alternatively, the chiral perturbation theory approach is used at the next-to-next-to-leading order with all relevant NN and 3N contributions taken into account. The generated dynamics is then applied to calculate cross-section values by rigorous solution of the 3N Faddeev equations. The comparison of the calculated cross sections with the experimental data shows a clear preference for the predictions in which the 3NF's are included. The majority of the experimental data points is well reproduced by the theoretical predictions. The remaining discrepancies are investigated by inspecting cross sections integrated over certain kinematical variables. The procedure of global comparisons leads to establishing regularities in disagreements between the experimental data and the theoretically predicted values of the cross sections. They indicate deficiencies still present in the assumed models of the 3N system dynamics

  8. Neutron-deuteron analyzing power data at En = 21 MeV and the energy dependence of the three-nucleon analyzing power puzzle

    Science.gov (United States)

    Weisel, G. J.; Tornow, W.; Esterline, J. H.

    2015-08-01

    We present measurements of n-d analyzing power, {A}y(θ ), at En = 21.0 MeV. The experiment produces neutrons via the 2H(d, n)3He reaction and uses a deuterated liquid-scintillator center detector and six pairs of liquid-scintillator neutron side detectors. Elastic neutron scattering events are identified by using time-of-flight techniques and by setting a gate in the center-detector pulse-height spectrum. Beam polarization is monitored by using a high-pressure helium gas scintillator. The n-d {A}y(θ ) data at 21.0 MeV show a significant discrepancy with the results of rigorous three-body calculations and are consistent with data taken previously by us at 19.0 and 22.5 MeV. We review the overall energy dependence of the three-nucleon analyzing power puzzle in neutron-deuteron elastic scattering, using the best data available. We find that the relative difference between calculations and data is nearly constant at 25% up to En = 22.5 MeV.

  9. The 58606264Ni(p,α)55575961Co reactions and their description by the semi-microscopic model for three-nucleon transfer

    International Nuclear Information System (INIS)

    Smits, J.W.; Siemssen, R.H.; Werf, S.Y. van der; Woude, A. van der

    1979-01-01

    The (p,α) reaction on the even-A nickel isotopes has been studied at an incident proton energy of 30 MeV. Between 14 and 26 states, or groups of states, were analysed for each of the residual cobalt isotopes. For these transitions angular distributions were determined from thetasub(lab) = 7.5 0 to 70 0 . In all reactions the proton-hole states (0fsub(7/2), 1ssub(1/2) and 0dsub(3/2)) stand out in the spectra. Also, states formed by the weak-coupling of the proton-holes to excitations of the neutron core were seen. Differences in the relative strengths of the positive-parity hole states between the proton pickup and the (p,α) data can be explained by a semi-microscopic model for three-nucleon transfer. Also the strength distribution of the transitions to the lowest weak-coupling quintuplet is correctly predicted. These results underline the importance of the inclusion of non-zero coupled neutron pairs into the description of (p, α) reactions. Several T> states are observed in the 58 Ni(p, α) 55 Co reactions

  10. Forma urbana tradicional e modernista:

    Directory of Open Access Journals (Sweden)

    Dr. Arq. Antônio Tarcìsio da Luz Reis

    2014-12-01

    Full Text Available O objetivo deste artigo é refletir sobre algumas das implicações da forma urbana tradicional e da forma urbana modernista, para o uso e estética dos espaços ur banos, tais como a existência de conexões visuais e funcionais entre as edifca- ções e os espaços abertos públicos e o uso dado aos pavimentos térreos. Na "for ma urbana tradicional" as edifcações possuem portas frontais e janelas voltadas para as ruas públicas, enquanto na "forma urbana modernista" as edifcações ten dem a ter portas e janelas distantes das vias públicas e/ou voltadas para espaços abertos internos ao quarteirão, sem distinção entre portas e janelas frontais e pos teriores. Assim, exemplos de cidades em diferentes países são utilizados para as comparações e reflexões envolvendo estes aspectos. As principais consequências destas análises reforçam a necessidade de um melhor entendimento em relação às implicações da forma urbana para o uso e a estética dos espaços urbanos. Adi cionalmente, destaca–se a importância da existência de conexões visuais e fun cionais entre os térreos das edifcações e os espaços abertos públicos para a vi talidade, segurança e aparência dos espaços urbanos.

  11. Contribution to the study of neutron-neutron interactions using the three-nucleon experiment D(n,nnp) at 14.5 MeV: evaluation of parasitic events

    International Nuclear Information System (INIS)

    Ducharme, C.

    1969-01-01

    This work is related to the interpretation of the results concerning the three nucleon experiment, D(n,nnp), at 14.5 MeV, carried out by double time-of-flight spectrometry. The present work consists in the simulation of the main parasitic events using the Monte-Carlo method for extracting them from the experimental distribution around the n-n pole. (author) [fr

  12. MOBILIDADE URBANA E TRAFFIC CALMING

    Directory of Open Access Journals (Sweden)

    Priscilla Alves

    2014-09-01

    Full Text Available O objetivo do presente trabalho é o de analisar e compreender, a partir de uma discussão teórica, o conceito e aplicação das medidas moderadoras de tráfego, conhecidas como traffic calming e sua relação com a mobilidade urbana sustentável. Buscou-se conhecer a aplicação da técnica no cenário mundial assim como algumas medidas adotadas no Brasil. Os procedimentos metodológicos aqui utilizados envolvem uma pesquisa exploratória, através da literatura atual e disponível, acerca dos temas mobilidade urbana sustentável e aplicação das medidas traffic calming. Conclui-se que as medidas de moderação atuam em conformidade com os princípios da mobilidade urbana sustentável na medida em que prioriza ações para redução do tráfego motorizado, e incentiva o uso e a segurança nos deslocamentos não motorizados. Contudo, a aplicação das técnicas sem estudos prévios e um planejamento estratégico não reduz os conflitos de mobilidade existentes nas localidades. No caso do Brasil para que se tenha sucesso com implantação da técnica é preciso uma análise mais abrangente, articulada e ser passível de aplicação de forma completa, assim como ocorre nos países desenvolvidos.

  13. LOS ESTUDIOS DE POBREZA URBANA

    Directory of Open Access Journals (Sweden)

    Rina De León Herrera

    2007-08-01

    Full Text Available En este artículo se intenta mostrar en forma sucinta la evolución de los estudios de pobreza urbana; se retoma para ello la producción escritural de investigadores que han hecho aportes valiosos sobre la temática en diferentes épocas y espacios geográficos. La información se ha organizado en dos unidades de análisis: la producción escritural en los países desarrollados y en los países en desarrollo.

  14. Paisagismo e as centralidades urbanas

    Directory of Open Access Journals (Sweden)

    Sérgio Marin de Oliveira

    2005-06-01

    Full Text Available Este texto sobre o Programa de Centralidades Urbanas (Centros de Bairros na cidade de São Paulo procura explicitar a importância que o projeto paisagístico teve em sua definição desde o início, destacando a relevância da questão ambiental em grandes centros urbanos. Não se tratou de projetar de modo reparador, complementar, ou ainda, de intervenções pontuais. O paisagismo, entendido em sua totalidade, foi mote e motor do programa. Sua coordenação (projetos, procedimentos burocráticos, acompanhamento e fiscalização das obras foi realizada pela Empresa Municipal de Urbanização (Emurb, com as secretarias municipais.

  15. Synthesis of indium-111 mesoprotoporphyrin IX

    International Nuclear Information System (INIS)

    Lee, K.M.; Marshall, A.G.

    1981-01-01

    Indium-111 mesoprotoporphyrin IX has been prepared by refluxing suitable proportions of InCl 3 , sodium acetate, and mesoprotoporphyrin IX in glacial acetic acid. The labeled metalloporphyrin is sufficiently water-soluble for use as a scanning agent, and can also be incorporated into heme apoproteins for perturbed gamma-gamma angular correlation measurements. (author)

  16. Rigenerazione urbana: professione, didattica, ricerca

    Directory of Open Access Journals (Sweden)

    Roberto Mingucci

    2011-12-01

    Full Text Available Il numero 3/2011 di IN_BO rappresenta una evoluzione significativa nella vita della rivista. Come da sempre abbiamo segnalato, IN_BO è nata per essere dedicata a temi che coinvolgono l’intero quadro di discipline nella formazione degli Ingegneri-Architetti, con l’obiettivo di mettere a confronto esperienze di ricerca e di studio orientate, in particolare, alla conoscenza, alla rappresentazione e al progetto del territorio, della città e dell’architettura. Questo numero realizza, in una sintesi molto efficace, questa intenzione, confrontando riflessioni, esperienze e progetti sul tema della rigenerazione urbana. Tra le finalità di IN_BO c’è anche quella di voler lavorare alla costruzione di una matura sensibilità progettuale, più legata ai valori e ai significati, pronta anche alla creatività e alla sperimentazione, piuttosto che al rigoroso rispetto normativo, seppure questo rappresenti un passaggio ineludibile e necessario. Ed è proprio quello che questo numero della rivista prova a fare, impostando un ragionamento, raccogliendo input nel confronto con esperienze internazionali, aprendosi a più letture e a più interpretazioni. Questa metodologia operativa è sicuramente utile per gli studenti e i ricercatori, ma allo stesso modo lo è anche per i tecnici e i professionisti, che nel mondo globale devono fare i conti con riferimenti, culturali e progettuali, che superano i confini nazionali, alla ricerca di una nuova dimensione e di una rinnovata identità. IN_BO, dunque, può essere strumento di conoscenza, divenendo recipiente di esperienze, e allo stesso tempo luogo di dialogo a più voci, aperto, continuo e costruttivo. Uno spazio dove l’accademia e la professione si incontrano, in un reciproco e proficuo scambio.

  17. Rehabilitación urbana en Lisboa

    OpenAIRE

    Lourés Seoane, María Luisa

    2001-01-01

    El artículo analiza la evolución reciente de las políticas de rehabilitacíón urbana en Lisboa desde una perspectiva sociológica. El texto aborda las transformaciones experimentadas por las áreas centrales de la ciudad en el contexto global del área metropolitana.

  18. Águas urbanas Urban waters

    Directory of Open Access Journals (Sweden)

    Carlos E. M. Tucci

    2008-01-01

    Full Text Available As águas urbanas geralmente incluem abastecimento de água e saneamento. Nessa perspectiva, saneamento envolve a coleta de tratamento de efluentes domésticos e industriais, não inclui drenagem urbana, gestão dos resíduos sólidos, porque ainda perdura uma visão desatualizada da gestão das águas urbanas da cidade. Águas urbanas envolvem componentes que permitem o desenvolvimento ambiental sustentável e utilizam os conceitos da gestão integrada dos recursos hídricos (GIRH, necessários para planejamento, implementação e manutenção da infra-estrutura da cidade. Nesse contexto, ficam denominados Gestão Integrada das Águas Urbanas. Neste artigo, analisam-se o desenvolvimento urbano e suas relações com as águas urbanas no Brasil. A gestão dos recursos hídricos no Brasil é realizada por bacias hidrográficas, e o domínio é federal ou estadual. Examinam-se as possibilidades de gestão da água na cidade e na bacia hidrográfica no contexto institucional brasileiro.Urban Waters systems generally include both water supply & sanitation facilities (WSS. Sanitation refers to domestic and industrial sewage collecting and treatment; it does not include urban stormwater or solid waste management systems. Urban water form components of a sustainable urban environment and the use of the integrated water resource management (IWRM concepts are needed for planning, implementation and maintenance of urban infrastructure. In urban environment, IWRM is referred to specifically as Integrated Urban Water Management (IUWM. In this paper urban development and its relations with urban waters in Brazil are assessed. Management of Water Resources in Brazil is developed by basins and the administration is Federal or from the state. This article assess the alternatives of water management in the city and the basin in the Brazilian institutional environment.

  19. Convergências e pontos de contato entre a Antropologia Urbana da juventude em Buenos Aires e São Paulo

    OpenAIRE

    Fiori, Ana Letícia de

    2015-01-01

    O lançamento de Hacerse un lugar: circuitos y trajectorias juveniles em ámbitos urbanos durante a IX Reunião de Antropologia do Mercosul, em Montevideo, ensejou o convite para que o Núcleo de Antropologia Urbana – NAU apresentasse uma leitura dos artigos que compõem o livro em uma perspectiva comparativa com os trabalhos que são desenvolvidos pelo NAU. Tratava-se, portanto, de comparações entre diferentes loci de pesquisa etnográfica (majoritariamente Buenos Aires e São Paulo), mas também de ...

  20. Title IX: With New Opportunities, Girls' Interest Rises

    Science.gov (United States)

    Toporek, Bryan

    2012-01-01

    On June 23, 1972, President Richard M. Nixon signed into law Title IX of the Education Amendments of 1972, which prohibits gender discrimination in any federally financed education program or activity. Title IX is far-reaching, but the law is most often associated with school and college athletics. Title IX allows schools to prove their athletic…

  1. 77 FR 64401 - Order of Succession for HUD Region IX

    Science.gov (United States)

    2012-10-19

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [FR-5550-D-12] Order of Succession for HUD Region IX... Field Offices (Region IX). This Order of Succession supersedes all previous Orders of Succession for HUD Region IX. DATES: Effective Date: October 9, 2012. FOR FURTHER INFORMATION CONTACT: Lawrence D. Reynolds...

  2. Providing Transparency to the Title IX Process

    Science.gov (United States)

    Hartle, Terry

    2017-01-01

    When U.S. Secretary of Education Betsy DeVos announced Sept. 7, 2017, that her department would revisit how Title IX rules are enforced with respect to campus sexual assault, she said the first step would be a "transparent notice and comment process" to replace the 2011 "guidance" (and follow up 2014 guidance) that has been…

  3. Platelet Glycoprotein Ib-IX and Malignancy

    Science.gov (United States)

    2010-09-01

    provide a unique microenvironment supporting the accumulation of more platelets and the elaboration of a fibrin - rich network produced by coagulation...process and can initiate the formation of a platelet - rich thrombus by tethering the platelet to a thrombogenic surface. Several ligands binding to GP Ib... Platelet Glycoprotein Ib-IX and Malignancy PRINCIPAL INVESTIGATOR: Jerry Ware, Ph.D

  4. Factor IX gene haplotypes in Amerindians.

    Science.gov (United States)

    Franco, R F; Araújo, A G; Zago, M A; Guerreiro, J F; Figueiredo, M S

    1997-02-01

    We have determined the haplotypes of the factor IX gene for 95 Indians from 5 Brazilian Amazon tribes: Wayampí, Wayana-Apalaí, Kayapó, Arára, and Yanomámi. Eight polymorphisms linked to the factor IX gene were investigated: MseI (at 5', nt -698), BamHI (at 5', nt -561), DdeI (intron 1), BamHI (intron 2), XmnI (intron 3), TaqI (intron 4), MspI (intron 4), and HhaI (at 3', approximately 8 kb). The results of the haplotype distribution and the allele frequencies for each of the factor IX gene polymorphisms in Amerindians were similar to the results reported for Asian populations but differed from results for other ethnic groups. Only five haplotypes were identified within the entire Amerindian study population, and the haplotype distribution was significantly different among the five tribes, with one (Arára) to four (Wayampí) haplotypes being found per tribe. These findings indicate a significant heterogeneity among the Indian tribes and contrast with the homogeneous distribution of the beta-globin gene cluster haplotypes but agree with our recent findings on the distribution of alpha-globin gene cluster haplotypes and the allele frequencies for six VNTRs in the same Amerindian tribes. Our data represent the first study of factor IX-associated polymorphisms in Amerindian populations and emphasizes the applicability of these genetic markers for population and human evolution studies.

  5. LA SUSTENTABILIDAD URBANA EN LAS CIUDADES.

    Directory of Open Access Journals (Sweden)

    Freddy Alexis Aponte Páez

    2007-06-01

    Full Text Available El desarrollo sustentable tiene como punto central lagente, en el sentido de que su principal objetivo es elmejoramiento de la calidad de vida del hombre, y estafundamentado en la conservación en el sentido de estarcondicionado por la necesidad de respetar la capacidadde la naturaleza para el suministro de recursos y serviciospara el mantenimiento de la vida.El desarrollo sustentable es una perspectiva amplia, conun enfoque antropocéntrico que integra las necesidadeshumanas y la problemática ambiental como elementosdentro de un mismo proyecto. De esta manera, el desarrollosustentable, por definición, busca promover laarmonía entre los seres humanos, y entre éstos y la naturaleza;para ello se basa en cuatro elementos: crecimientoeconómico, balance ambiental, equidad y responsabilidady eficiencia de las instituciones públicas.El concepto de sustentabilidad urbana es consideradocomo un estado de equilibrio entre las dimensiones social,económica y ambiental en el espacio de la ciudad.La discusión de sustentabilidad urbana incorpora el tipode interacción que se establece entre ciudad y región yque hace posible la vida urbana. Los estudios de metabolismourbano destacan tanto, los insumos de la regiónhacia la ciudad y los flujos de la ciudad hacia la región.

  6. Drenagem urbana: centro histórico de Leiria

    OpenAIRE

    Martins, Wilson Antunes Xavier

    2016-01-01

    No que concerne ao funcionamento de um sistema de drenagem urbana a maior preocupação é o encaminhamento das águas provenientes de precipitações ocorrentes em áreas urbanas para pontos de descarga no meio recetor fora das zonas urbanas, o mais rápido possível. Os centros urbanos estão munidos de diversos tipos de ocupação do solo, conduzindo ao aumento da impermeabilização do solo, que em termos de drenagem urbana não é vantajoso porque reduz a capacidade de infiltração no solo, aumentando...

  7. Violencia urbana y criminalidad urbana en la ciudad de San José. Un estudio exploratorio.

    OpenAIRE

    Guillermo Carvajal Alvarado; David Rivera

    2011-01-01

    La tendencia ascendente de la violencia urbana, estimada en un 4% alrededor del mundo en los decenios de 1980 y 1990, está provocando cambios importantes en el paisaje y en la vida diaria de la zonas urbanas. En muchas ciudades, el miedo a la violencia ha alejado a la población de los transportes, las calles y los espacios públicos. Las calles donde solían jugar los niños y congregarse los vecinos, y por las que paseaba la gente, se utilizan ahora mucho menos.

  8. MOBILIDADE URBANA E A POBREZA DA CIDADANIA

    Directory of Open Access Journals (Sweden)

    Joseval Melo Santana

    2014-12-01

    Full Text Available O objetivo deste artigo é analisar mediante um debate crítico, dialético, histórico e bibliográfico a mobilidade urbana nas cidades brasileiras sob a égide da sua cidadania. As cidades não só nasceram em virtude da mobilidade humana, como também se mantêm por causa dela. Por sua vez, as cidades refletem e são refletidas pelas condições econômicas, sociais e culturais do seu povo, ou melhor, dos cidadãos (indivíduos em pleno gozo dos seus direitos civis e políticos e sujeitos as obrigações inerentes a sua condição. A mobilidade humana é, foi, e sempre será condição da própria existência e sobrevivência humana. Desde os tempos remotos, observa-se que a mobilidade humana segue pari passu com o desenvolvido tecnológico e o estágio social, cultural e econômico de cada povo. Pelo exposto, o estudo da mobilidade urbana não pode se restringir a uma análise sistêmica de domínio da engenharia de trânsito, uma vez que a mobilidade urbana tem raízes profundas na dimensão do próprio ser humano e do seu estado evolutivo. Muito além de um trânsito lento, marcado por longos engarrafamentos, a mobilidade urbana revela-se como um indicador, um “termômetro” do estado “civilizatório” ou da cidadania de um povo. É mister reconhecer que a mobilidade urbana afeta e é afetada de forma diferente nas diferentes culturas. Isso pode explicar, em parte, porque grandes cidades da Inglaterra, dos Estados Unidos, do Japão etc. tiveram êxito na minimização dos problemas do trânsito nas suas vias urbanas, enquanto no Brasil, mesmo diante de esforços pontuais dos gestores da administração pública, em particular dos órgãos de engenharia de trânsito, têm até o presente momento revelado resultados insatisfatórios, conforme pode ser observado pelos engarrafamentos que surgem ou tornam-se cada vez maiores. Assim, ao retratar as origens e desenvolvimento das cidades brasileiras com a sua cidadania busca-se, aqui

  9. Many-body theory of nuclear and neutron star matter

    Energy Technology Data Exchange (ETDEWEB)

    Pandharipande, V R; Akmal, A; Ravenhall, D G [Dept. of Physics, Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States)

    1998-06-01

    We present results obtained for nuclei, nuclear and neutron star matter, and neutron star structure obtained with the recent Argonne v{sub 18} two- nucleon and Urbana IX three-nucleon interactions including relativistic boost corrections. These interactions predict that matter will undergo a transition to a spin layered phase with neutral pion condensation. We also consider the possibility of a transition to quark matter. (orig.)

  10. Many-body theory of nuclear and neutron star matter

    International Nuclear Information System (INIS)

    Pandharipande, V.R.; Akmal, A.; Ravenhall, D.G.

    1998-01-01

    We present results obtained for nuclei, nuclear and neutron star matter, and neutron star structure obtained with the recent Argonne v 18 two- nucleon and Urbana IX three-nucleon interactions including relativistic boost corrections. These interactions predict that matter will undergo a transition to a spin layered phase with neutral pion condensation. We also consider the possibility of a transition to quark matter. (orig.)

  11. Paisagem, ecologia urbana e planejamento ambiental

    OpenAIRE

    Barbosa, Valter Luís; Nascimento Júnior, Antônio Fernandes

    2009-01-01

    A chegada das grandes massas populacionais aos centros urbanos tem modificado a paisagem da cidade assustadoramente e de maneira agressiva vem se instalando em espaços vazios impróprios à moradia que fazem parte de reservas ecológicas e de matas ciliares nos mananciais. No planejamento urbano há diretrizes para o uso e ocupação do solo, todavia, a expansão urbana continua desordenada e irregular, ferindo os princípios básicos de uma sociedade sustentável. Logo, é imprescindível que o poder pú...

  12. Criminalidad-estructura urbana: Tijuana 2002

    Directory of Open Access Journals (Sweden)

    José García Gómez

    2009-01-01

    Full Text Available La búsqueda de la relación entre algunos aspectos de la estructura urbana de la ciudad de Tijuana y el fenómeno de criminalidad durante el 2002, sirve de pretexto para, en primer término, establecer la pertinencia de abordar el análisis de la relación desarrollo urbano-criminalidad desde la perspectiva de la teoría de sistemas, particularmente desde el enfoque de ciudad como sistema planteada por Schmidt-Relenberg. También sirve para justificar el uso de una técnica econométrica (la regresión. Bajo ese enfoque y herramientas analíticas descritas se lleva a cabo el análisis tomando como variable de criminalidad a los robos con violencia y sin violencia y como variables de estructura física urbana a las características geométricas y los componentes principales en vialidades. La evaluación estadística arroja que de manera conjunta las dos variables de configuración física señaladas no explican la criminalidad, pero si lo hacen de manera individual.

  13. DIMENSIONES CULTURALES DE LA MOVILIDAD URBANA

    Directory of Open Access Journals (Sweden)

    Carlos Lange Valdés

    2011-01-01

    Full Text Available La movilidad urbana, y particularmente aquella desarrollada de manera cotidiana por los habitantes de la ciudad, constituye una problemática de creciente y progresiva relevancia tanto para el funcionamiento del sistema urbano como para el desenvolvimiento de la vida social. Si bien ella ha sido objeto de reflexión desde tiempos pretéritos, es a partir de la consolidación del paradigma de la ciudad global y de su incesante expansión en redes y flujos que su trascendencia pone en cuestión la conformación misma de "lo urbano", generando nuevas interrogantes sobre sus tradicionales enfoques de comprensión. Lo anterior tiene particular importancia para las ciencias sociales, en la medida que éstas se enfrentan al desafío de ampliar su marco de comprensión respecto de sus dimensiones socioculturales que ella conlleva. Desde esta perspectiva, este trabajo establece tres planteamientos en relación al abordaje de la movilidad urbana desde las ciencias sociales. El primero busca dar cuenta de la relevancia que ésta posee como objeto de estudio. El segundo se orienta a delinear una perspectiva sociocultural de la misma. Por último, el tercer planteamiento presenta algunas interrogantes que podrían suponer líneas de investigación futuras en torno a su desarrollo.

  14. Evaluation of factor IX deficiency by interdigitated electrode (IDE)

    Science.gov (United States)

    Gopinath, Subash C. B.; Hashim, Uda; Uda, M. N. A.

    2017-03-01

    Factor IX deficiency is the main cause of hemophilia A and B. This a severe excessive bleeding disorder that can even kill the patient if not treated with the right prescription of Factor IX hormone to stop the bleeding. The bleeding can be caused by an injury or even a sudden bleeding in some very rare cases. To find the Factor IX effectiveness and to understand the deficiency more carefully for the future of medicine, experiments are conducted to test the Factor IX using the Interdigitated Electrode (IDE) and gold Nanoparticle with the help of Nanoelectrical technology.

  15. Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment

    Czech Academy of Sciences Publication Activity Database

    Závadová, Zuzana; Závada, Jan

    2005-01-01

    Roč. 13, č. 5 (2005), s. 977-982 ISSN 1021-335X R&D Projects: GA ČR(CZ) GA203/02/0405 Institutional research plan: CEZ:AV0Z50520514 Keywords : carbonic anhydrase IX * cell adhesion * microenvironment Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.572, year: 2005

  16. Hablando de ensanches y cicatrices urbanas

    Directory of Open Access Journals (Sweden)

    Waldo Martínez Riquelme

    2001-12-01

    Full Text Available El presente artículo es de carácter analítico descriptivo y se basa en realidades urbanas que he podido apreciar a lo largo de veinticinco años de trabajo ligado al desarrollo urbano. En este caso en particular se trata de reflexiones en torno a los resultados de un fenómeno, como los ensanches de calles, que saltan a la vista y sobre los cuales vale la pena hacerse algunos cuestionamientos, de manera tal de motivar a la revisión de ciertas políticas o formas de enfrentar el problema, tanto por parte de la autoridad como de los ciudadanos todos.

  17. Ambientalismo, sustentabilidad urbana y desarrollo regional

    Directory of Open Access Journals (Sweden)

    Erick Gómez Tagle López

    2004-01-01

    Full Text Available En este artículo, el autor analiza, en el marco del crecimiento de las ciudades, del libre mercado, del empobrecimiento de los sectores rurales, de la degradación ecológica y de la pérdida de biodiversidad, el tema urgente del medio ambiente en la agenda mundial y su sustentabilidad urbana y regional. A lo largo de su trabajo, el autor obliga a repensar la globalización desde el espacio local, valorando que este proceso ha beneficiado a pocos países y empresas transnacionales quienes, haciendo uso del dinero y la tecnología, han acelerado la insustentabilidad socioambiental.

  18. Ares I-X Ground Diagnostic Prototype

    Science.gov (United States)

    Schwabacher, Mark A.; Martin, Rodney Alexander; Waterman, Robert D.; Oostdyk, Rebecca Lynn; Ossenfort, John P.; Matthews, Bryan

    2010-01-01

    The automation of pre-launch diagnostics for launch vehicles offers three potential benefits: improving safety, reducing cost, and reducing launch delays. The Ares I-X Ground Diagnostic Prototype demonstrated anomaly detection, fault detection, fault isolation, and diagnostics for the Ares I-X first-stage Thrust Vector Control and for the associated ground hydraulics while the vehicle was in the Vehicle Assembly Building at Kennedy Space Center (KSC) and while it was on the launch pad. The prototype combines three existing tools. The first tool, TEAMS (Testability Engineering and Maintenance System), is a model-based tool from Qualtech Systems Inc. for fault isolation and diagnostics. The second tool, SHINE (Spacecraft Health Inference Engine), is a rule-based expert system that was developed at the NASA Jet Propulsion Laboratory. We developed SHINE rules for fault detection and mode identification, and used the outputs of SHINE as inputs to TEAMS. The third tool, IMS (Inductive Monitoring System), is an anomaly detection tool that was developed at NASA Ames Research Center. The three tools were integrated and deployed to KSC, where they were interfaced with live data. This paper describes how the prototype performed during the period of time before the launch, including accuracy and computer resource usage. The paper concludes with some of the lessons that we learned from the experience of developing and deploying the prototype.

  19. Title IX--Beyond Compliance to Personal Commitment and Leadership

    Science.gov (United States)

    Peterson, Barbara

    1976-01-01

    In order to move beyond legal compliance to real equality of opportunity, every educational leader must develop some systematic means of extending his or her personal knowledge and skills with respect to Title IX. Provides a check list for self evaluation of educational leaders and a guide for developing an implementation plan for Title IX.…

  20. A License for Bias: Sex Discrimination, Schools, and Title IX.

    Science.gov (United States)

    Morse, Susan Ed.

    This report discusses non-sports-related Title IX complaints filed with the Department of Education's Office for Civil Rights (OCR) from 1993-1997. Its purpose is to dispel the popular belief that Title IX is a sports-equity law and to determine the effectiveness of the legislation. The document examines the kinds of complaints filed, the status…

  1. Tissue-specific expression of type IX collagen

    International Nuclear Information System (INIS)

    Nishimura, I.; Muragaki, Y.; Ninomiya, Y.; Olsen, B.R.; Hayashi, M.

    1990-01-01

    This paper reports on the tissue-specific expression of type IX collagen, a major component of cartilage fibrils. It contains molecules with three genetically distinct subunits. The subunits form three triple-helical (CO) domains separated by non-triple-helical (NC) sequences. One of the subunits in cartilage, α1(IX), contains a large amino-terminal globular domain, NC4, while a second subunit, α2(IX), contains a covalently attached chondroitin sulfate chain. The site of attachment for this chain is located within the non-triple-helical sequence NC3, which separates the amino-terminal and central triple-helical domains of the type IX molecules. The NC3 region is 5 amino acid residues longer in the α2(IX) chain than in the α1(IX) and α3(IX) chains. This may explain why type IX molecules tend to show a sharp angle in the NC3 region, and why monoclonal antibody molecules that are specific for the stub left after chondroitinase ABC digestion of the chondroitin sulfate side chain always are located on the outside of the angle

  2. The History, Uses, and Abuses of Title IX. 2016 Bulletin

    Science.gov (United States)

    American Association of University Professors, 2016

    2016-01-01

    This report, an evaluation of the history and current uses of Title IX, is the result of a joint effort by a subcommittee that included members of the AAUP's Committee A on Academic Freedom and Tenure and the Committee on Women in the Academic Profession. The report identifies tensions between current interpretations of Title IX and the academic…

  3. Intrinsic thermodynamics of inhibitor binding to human carbonic anhydrase IX.

    Science.gov (United States)

    Linkuvienė, Vaida; Matulienė, Jurgita; Juozapaitienė, Vaida; Michailovienė, Vilma; Jachno, Jelena; Matulis, Daumantas

    2016-04-01

    Human carbonic anhydrase 9th isoform (CA IX) is an important marker of numerous cancers and is increasingly interesting as a potential anticancer drug target. Various synthetic aromatic sulfonamide-bearing compounds are being designed as potent inhibitors of CA IX. However, sulfonamide compound binding to CA IX is linked to several reactions, the deprotonation of the sulfonamide amino group and the protonation of the CA active site Zn(II)-bound hydroxide. These linked reactions significantly affect the affinities and other thermodynamic parameters such as enthalpies and entropies of binding. The observed and intrinsic affinities of compound binding to CA IX were determined by the fluorescent thermal shift assay. The enthalpies and entropies of binding were determined by the isothermal titration calorimetry. The pKa of CA IX was determined to be 6.8 and the enthalpy of CA IX-Zn(II)-bound hydroxide protonation was -24 kJ/mol. These values enabled the analysis of intrinsic thermodynamics of a library of compounds binding to CA IX. The most strongly binding compounds exhibited the intrinsic affinity of 0.01 nM and the observed affinity of 2 nM. The intrinsic thermodynamic parameters of compound binding to CA IX helped to draw the compound structure to thermodynamics relationship. It is important to distinguish the intrinsic from observed parameters of any disease target protein interaction with its inhibitors as drug candidates when drawing detailed compound structure to thermodynamics correlations. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Labeled factor IX kinetics in patients with hemophilia-B

    International Nuclear Information System (INIS)

    Smith, K.J.; Thompson, A.R.

    1981-01-01

    Labeled factor IX was infused five time into four patients with hemophilia-B. Ten-minute plasma recovery average 35% (SD +/- 2) and the mean T 1/2 beta-phase elimination was 23 hr (+/- 5). No alteration in the postinfusion 125I-factor-IX could be detected by radioautography of plasma samples run on polyacrylamide gels or on crossed-immunoelectrophoresis. Label was excreted into the urine as free 125I-iodide. Kinetics were similar when the labeled preparation was infused alone or with a commercial concentrate containing unlabeled factor IX. Infusion of factor IX in man is best described by a two-compartment open pharmacokinetic model where factor IX is distributed in a space larger than the plasma volume

  5. Ares I-X Flight Test Philosophy

    Science.gov (United States)

    Davis, S. R.; Tuma, M. L.; Heitzman, K.

    2007-01-01

    In response to the Vision for Space Exploration, the National Aeronautics and Space Administration (NASA) has defined a new space exploration architecture to return humans to the Moon and prepare for human exploration of Mars. One of the first new developments will be the Ares I Crew Launch Vehicle (CLV), which will carry the Orion Crew Exploration Vehicle (CEV), into Low Earth Orbit (LEO) to support International Space Station (ISS) missions and, later, support lunar missions. As part of Ares I development, NASA will perform a series of Ares I flight tests. The tests will provide data that will inform the engineering and design process and verify the flight hardware and software. The data gained from the flight tests will be used to certify the new Ares/Orion vehicle for human space flight. The primary objectives of this first flight test (Ares I-X) are the following: Demonstrate control of a dynamically similar integrated Ares CLV/Orion CEV using Ares CLV ascent control algorithms; Perform an in-flight separation/staging event between an Ares I-similar First Stage and a representative Upper Stage; Demonstrate assembly and recovery of a new Ares CLV-like First Stage element at Kennedy Space Center (KSC); Demonstrate First Stage separation sequencing, and quantify First Stage atmospheric entry dynamics and parachute performance; and Characterize the magnitude of the integrated vehicle roll torque throughout the First Stage (powered) flight. This paper will provide an overview of the Ares I-X flight test process and details of the individual flight tests.

  6. IBM PC/IX operating system evaluation plan

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Granier, Martin; Hall, Philip P.; Triantafyllopoulos, Spiros

    1984-01-01

    An evaluation plan for the IBM PC/IX Operating System designed for IBM PC/XT computers is discussed. The evaluation plan covers the areas of performance measurement and evaluation, software facilities available, man-machine interface considerations, networking, and the suitability of PC/IX as a development environment within the University of Southwestern Louisiana NASA PC Research and Development project. In order to compare and evaluate the PC/IX system, comparisons with other available UNIX-based systems are also included.

  7. Electrophysiology of Cranial Nerve Testing: Cranial Nerves IX and X.

    Science.gov (United States)

    Martinez, Alberto R M; Martins, Melina P; Moreira, Ana Lucila; Martins, Carlos R; Kimaid, Paulo A T; França, Marcondes C

    2018-01-01

    The cranial nerves IX and X emerge from medulla oblongata and have motor, sensory, and parasympathetic functions. Some of these are amenable to neurophysiological assessment. It is often hard to separate the individual contribution of each nerve; in fact, some of the techniques are indeed a composite functional measure of both nerves. The main methods are the evaluation of the swallowing function (combined IX and X), laryngeal electromyogram (predominant motor vagal function), and heart rate variability (predominant parasympathetic vagal function). This review describes, therefore, the techniques that best evaluate the major symptoms presented in IX and X cranial nerve disturbance: dysphagia, dysphonia, and autonomic parasympathetic dysfunction.

  8. en un contexto de agricultura urbana

    Directory of Open Access Journals (Sweden)

    Fernando Neira Orjuela

    2005-01-01

    Full Text Available En el presente artículo se muestran los principales hallazgos en relación con la investigación realizada en San Luis Tlaxialtemalco, población que cuenta con 12 553 habitantes y se localiza en la delegación de Xochimilco en la zona sur de la Ciudad de México. Este pueblo, que desarrolla la agricultura urbana, ha brindado una excelente oportunidad para examinar, mediante la aplicación de una encuesta a 185 hogares, si los invernaderos son una opción viable para generar ingresos en los hogares, y cuáles son las formas de participación económica familiar y de división sexual del trabajo que determinan. Asimismo ha permitido aclarar si el acceso a recursos económicos, la edad y la escolaridad le otorgan o no a las esposas la última palabra en la toma de decisiones y en la libertad de movimiento, comparándolos con las que ejercen las esposas del pueblo dedicadas a las actividades asalariadas y a las no asalariadas no agrícolas.

  9. Legal Forum: Title IX: Does It Apply to Employees?

    Science.gov (United States)

    McCarthy, Martha

    1981-01-01

    Briefly reviews a number of Federal court cases that have dealt with Title IX, considering the issue of whether the 1974 regulations prohibiting sex discrimination in employment practices accurately reflect the intent of the 1972 law. (GC)

  10. Protoporphyrin IX-induced structural and functional changes in ...

    Indian Academy of Sciences (India)

    Unknown

    Drug-protein binding; haemoglobin; myoglobin; protoporphyrin IX; red blood cells ... haemoglobin and myoglobin are potentiated by the protein-porphyrin complexation. Possible ...... 1985 Uptake and delivery of the respiratory gases; in Best ...

  11. Estado, mercado de tierra urbana e inundaciones en ciudades argentinas

    Directory of Open Access Journals (Sweden)

    Nora Clichevsky

    2006-01-01

    Full Text Available En este trabajo se presentan los resultados de una investigación sobre las relaciones que se establecen entre los mercados de tierra urbana y las inundaciones en ciudades argentinas, en el marco más amplio de la vulnerabilidad urbana. Se pretende despejar incógnitas acerca del papel jugado por el Estado como regulador del mercado en áreas urbanas con vulnerabilidad natural a la inundación y como constructor de defensas contra las inundaciones y acerca de los impactos que han tenido las inundaciones y las obras de defensa contra ellas sobre el mercado de tierra y, por lo tanto, sobre el acceso al suelo urbano por parte de los distintos sectores de la población.

  12. Sistemas de gestión urbana regional

    OpenAIRE

    Biere Arenas, Rolando Mauricio

    2009-01-01

    Este proyecto busca compartir prácticas exitosas y uso de tecnologías avanzadas en la gestión urbana regional, a través del intercambio y formación conjunta entre instituciones de España, México y Chile que desarrollan este tema. Este trabajo expone la síntesis de la propuesta denominada Sistemas de Gestión Urbana Regional, desarrollada en el marco de la Convocatoria 2009 de la Agencia Española de Cooperación Internacional para el Desarrollo de Proyectos de Cooperación para Iberoamérica....

  13. Action of the protoporphyrin-Ix (Pp-Ix) in the life period of Drosophila mutants deficient in endogenous antioxidants

    International Nuclear Information System (INIS)

    Vidal E, L. M.

    2012-01-01

    The human being is daily exposed to free radicals or reactive oxygen species (Ros), as a result of the breathing and the interactions with xenobiotics that can cause irreversible lesions in molecules and cellular structures and that they are associated to diseases like the cancer, neuro degenerative and to the acceleration of the normal process of aging. Fortunately, to reduce the damaging effect of the Ros the cell has endogenous antioxidant systems constituted by antioxidant enzymes as: the superoxide dismutase (Sod), the catalase (Cat), and the glutathione peroxidase and reductase. Even, when these systems are not enough, we find to the exogenous antioxidants that cooperate in the balance of the Ros, as the porphyrins that include to the chlorophyllin, the hemin and the bilirubin among others. The protoporphyrin-Ix (Pp-Ix) is a tetra pyrrole without metallic center with antimutagenic and antioxidant activity similar to that of the chlorophyllin. However, is also known that their over-expression has toxic effects, because induces Ros. In Drosophila melanogaster, recently was found that the Pp-Ix have dual action anti and persistent mutagenic. One of their possible mechanism to act like mutagen is through the Ros induction. To evaluate this possibility and based in that the increase in the Ros levels can accelerate the aging process, in the present work the Pp-Ix role was evaluated, in the life period of Drosophila melanogaster strains deficient in Sod and Cat, sensitive to radiation or oxidative stress (rad, whd and flr 3 ) and a wild one as control (C-S). Females and males of each strain were treated chronically for separate with sucrose or Pp-Ix and every 15 days a group of each sex was irradiated with 10 Gy of gamma rays. The results indicated that the chronic treatment with Pp-Ix and in combination with radiation, increased the life period of the C-S strain. The Sod strain had a contrary effect and this effect was pronounced with the combined treatment of Pp-Ix

  14. Avances en la agenda urbana : Santa Cruz de la Sierra

    NARCIS (Netherlands)

    F. Steinberg (Florian); M.L. Garnelo (Maria Luisa); Zwanenburg Maria Zwanenburg (M.)

    2001-01-01

    textabstractEste libro tiene como objetivo principal, presentar algunos trabajos del SINPA que contribuyeron y representan “Avances en la Gestión Urbana”. Estos artículos son fruto de la experiencia del proyecto SINPA como aporte a los cambios y procesos de fortalecimiento de la gestión urbana en el

  15. Loteamentos, expansão e estrutura urbana

    Directory of Open Access Journals (Sweden)

    Décio Rigatti

    2002-06-01

    Full Text Available O rápido processo de urbanização que as cidades brasileiras apresentam, principalmente, a partir do final da década de 40, gera um crescimento acelerado da população urbana e produz nas cidades uma enorme demanda por terra urbanizada. O presente trabalho tem como objetivos centrais: analisar o parcelamento do solo urbano como modalidade de expansão de áreas urbanas; avaliar de que modo a incorporação de novas áreas, como urbanas, insere-se no tecido preexistente; examinar como os diversos parcelamentos do solo urbano estruturam o conjunto do tecido urbano, gerando diferentes níveis de acessibilidade geral; indicar medidas que o poder público municipal pode inserir como formas de controle e superação dos problemas apresentados presentemente. Como estudo de caso, discutiremos a formação e estruturação da cidade de Alvorada, localizada no limite leste de Porto Alegre, cidade que se originou da implantação de sucessivos loteamentos, ao invés da expansão de um núcleo urbano preexistente. O trabalho consiste, essencialmente, na reconstituição do processo de formação da estrutura urbana de Alvorada, a partir da inclusão sistemática de parcelamentos do solo ao longo do tempo e na avaliação da estrutura urbana resultante e suas relações com os potenciais de práticas sociais no espaço.

  16. Ares I-X: First Flight of a New Generation

    Science.gov (United States)

    Davis, Stephan R.; Askins, Bruce R.

    2010-01-01

    The Ares I-X suborbital development flight test demonstrated NASA s ability to design, develop, launch and control a new human-rated launch vehicle (Figure 14). This hands-on missions experience will provide the agency with necessary skills and insights regardless of the future direction of space exploration. The Ares I-X team, having executed a successful launch, will now focus on analyzing the flight data and extracting lessons learned that will be used to support the development of future vehicles.

  17. Synthesis of [119mSn]-mesoporphyrin IX dichloride

    International Nuclear Information System (INIS)

    Denissen, J.F.

    1990-01-01

    Tin mesoporphyrin IX dichloride (Sn-MPCl 2 ) is a heme oxygenase inhibitor of current clinical interest for the treatment of neonatal hyperbilirubinemia. The synthesis of [ 119m Sn]-MPCl 2 for drug metabolism and disposition studies is reported. [ 119m Sn]-MPCl 2 was prepared in 60% radiochemical yield by metalation of the porphyrin nucleus of mesoporphyrin IX dihydrochloride with tin(II)-119m acetate. The product had a specific activity of 43.4 mCi/mmol and a radiochemical purity of 99%, as determined by radio-HPLC analysis. (author)

  18. Effect of IX dosing on polypropylene and PVDF membrane fouling control

    KAUST Repository

    Myat, Darli Theint; Mergen, Max R D; Zhao, Oliver; Stewart, Matthew B.; Orbell, John D.; Merle, Tony; Croue, Jean-Philippe; Gray, Stephen R.

    2013-01-01

    The performance of ion exchange (IX) resin for organics removal from wastewater was assessed using advanced characterisation techniques for varying doses of IX. Organic characterisation using liquid chromatography with a photodiode array (PDA

  19. Identidad y fronteras urbanas en Santiago de Chile

    Directory of Open Access Journals (Sweden)

    Francisca Márquez

    2003-12-01

    Full Text Available Este articulo analiza a través de un ejercicio etnográfico los procesos de construcción identitaria de los habitantes de barrios pobres y medios de la ciudad de Santiago de Chile. Se plantea que las identidades que alli se construyen son expresión de los procesos de segregación urbana de la ciudad de Santiago y ellas dan cuenta del debilitamiento de un modelo urbano asentado en la heterogeneidad social, la noción de espacio público y valores como la ciudadanía política y la integración social. Paradojalmente, esta misma segregación urbana abre también paso a un imaginario y una práctica de vida comunitaria y tribal que refuerza y protege al nosotros de la peligrosidad de los otros.

  20. PROCESO DE FORMACIÓN URBANA DE ORIHUELA (ALICANTE

    Directory of Open Access Journals (Sweden)

    Gregorio Canales Martínez

    1992-01-01

    Full Text Available La evolución urbana de Orihuela ha venido marcada por un progresivo desplaza- miento desde su primitiva ubicación de carácter defensivo en el Monte San Miguel hasta ir ocupando las tierras ribereñas del río Segura, cuyo cauce ha definido hasta fechas muy cercanas su desarrollo urbano. El estudio determina los elementos y circunstancias que han condicionado el proceso de formación urbana desde el siglo XIV hasta nuestros días y sus tendencias expansivas, a través del análisis de la documentación histórica disponi- ble, tanto gráfica como bibliográfica, ofreciendo así una síntesis de la evolución histórica de la ciudad.

  1. El incremento de población urbana del Magreb

    Directory of Open Access Journals (Sweden)

    Raquel Barras

    2013-01-01

    Full Text Available Este artículo analiza el proceso de transición demográfica en el Magreb, en particular la fuerte urbanización quehan sufrido tres países: Argelia, Marruecos y Túnez. La población urbana se ha incrementado en la región, dando lugar a múltiples oportunidades, pero también a numerosos desafíos. La aparición de importantes centros urbanos espontáneos entorno a las grandes ciudades como consecuencia del éxodo rural ponen de manifiesto la existencia de notables dificultades demográficas que condicionarán el futuro de los tres países analizados, en el ámbito económico, social y de seguridad. El incremento de la población urbana jugará un papel fundamental en la demanda de alimentos en estos Estados.

  2. IX : An OS for datacenter applications with aggressive networking requirements

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    The conventional wisdom is that aggressive networking requirements, such as high packet rates for small messages and microsecond-scale tail latency, are best addressed outside the kernel, in a user-level networking stack. We present IX, a dataplane operating system designed to support low-latency, high-throughput and high-connection count applications.  Like classic operating systems such as Linux, IX provides strong protection guarantees to the networking stack.  However, and unlike classic operating systems, IX is designed for the ground up to support applications with aggressive networking requirements on dense multi-core platforms with 10GbE and 40GbE Ethernet NICs.  IX outperforms Linux by an order of magnitude on micro benchmarks, and by up to 3.6x when running an unmodified memcached, a popular key-value store. The presentation is based on the joint work with Adam Belay, George Prekas, Ana Klimovic, Sam Grossman and Christos Kozyrakis, published at OSDI 2014; Best P...

  3. Dynamic of exact perturbations in Bianchi IX type cosmological models

    International Nuclear Information System (INIS)

    Mello Neto, J.R.T. de.

    1985-01-01

    The dynamic of Bianchi IX type cosmological models is studied, after reducing Einstein equations to Hamiltonian system. Using the Melnikov method, the existence of chaos in the dynamic of these models is proved, and some numerical experiments are carried out. (M.C.K.) [pt

  4. Phase-space dynamics of Bianchi IX cosmological models

    International Nuclear Information System (INIS)

    Soares, I.D.

    1985-01-01

    The complex phase-space dynamical behaviour of a class of Biachi IX cosmological models is discussed, as the chaotic gravitational collapse due Poincare's homoclinic phenomena, and the n-furcation of periodic orbits and tori in the phase space of the models. Poincare maps which show this behaviour are constructed merically and applications are discussed. (Author) [pt

  5. Methods of producing protoporphyrin IX and bacterial mutants therefor

    Science.gov (United States)

    Zhou, Jizhong; Qiu, Dongru; He, Zhili; Xie, Ming

    2016-03-01

    The presently disclosed inventive concepts are directed in certain embodiments to a method of producing protoporphyrin IX by (1) cultivating a strain of Shewanella bacteria in a culture medium under conditions suitable for growth thereof, and (2) recovering the protoporphyrin IX from the culture medium. The strain of Shewanella bacteria comprises at least one mutant hemH gene which is incapable of normal expression, thereby causing an accumulation of protoporphyrin IX. In certain embodiments of the method, the strain of Shewanella bacteria is a strain of S. loihica, and more specifically may be S. loihica PV-4. In certain embodiments, the mutant hemH gene of the strain of Shewanella bacteria may be a mutant of shew_2229 and/or of shew_1140. In other embodiments, the presently disclosed inventive concepts are directed to mutant strains of Shewanella bacteria having at least one mutant hemH gene which is incapable of normal expression, thereby causing an accumulation of protoporphyrin IX during cultivation of the bacteria. In certain embodiments the strain of Shewanella bacteria is a strain of S. loihica, and more specifically may be S. loihica PV-4. In certain embodiments, the mutant hemH gene of the strain of Shewanella bacteria may be a mutant of shew_2229 and/or shew_1140.

  6. 23. IX korraldab Vaala galerii kunstioksjoni "Väliseesti eri"

    Index Scriptorium Estoniae

    2004-01-01

    Oksjonil on esindatud Eerik Haamer, Jaan Grünberg, Arno Vihalemm, Eduard Wiiralt, Ruth Tulving, Endel Kõks, Harald Jürissaar, Otto Paas, Ville Tops, Otto Puusta. Töödega saab tutvuda alates 18. IX, traditsiooniline sügisoksjon toimub 18. XI

  7. IX Congress of Spanish radiation protection Society (Bilbao, May-2002)

    International Nuclear Information System (INIS)

    2002-01-01

    The present book contains the papers presented to the IX Congress of Spanish Radiation Protection Society. The main sessions were : 1.- Scientific area of Radiation Protection and Regulation, Social aspects, Radioactive waste management and Dismantling. 2.- Radiation protection in Medical applications. 3.- Physics of radiations and their measurements

  8. Study of primitive universe in the Bianchi IX model

    International Nuclear Information System (INIS)

    Matsas, G.E.A.

    1988-03-01

    The theory of general relativity is used to study the homogeneous cosmological model Bianch IX with isometry group SO(3) near the cosmological singularity. The Bogoyavlenskii-Novikov formalism to explain the anusual behaviour of the Liapunov exponent associated with this chaotic system, is introduced. (author) [pt

  9. Title IX and Sexual Harassment of Student Athletes.

    Science.gov (United States)

    Wolohan, John T.

    1995-01-01

    This article reviews what constitutes sexual harassment in sports by examining Title IX of the Education Amendments of 1972 and the effect it has had on charges of sexual harrassment in educational institutions. Athletic administrators are provided with strategies and recommendations to help schools and athletic departments develop sexual…

  10. Counselor Education and Title IX: Current Perceptions and Questions

    Science.gov (United States)

    Welfare, Laura E.; Wagstaff, Jennifer; Haynes, Jenna R.

    2017-01-01

    This national survey of counselor educator perceptions of the Title IX requirement to report student disclosures of gender-based discrimination revealed the need for greater clarity about faculty strategies for serving counseling program students while upholding the federal law. The authors describe the recent expansion of the requirements and…

  11. Arqueoastronomía y la traza urbana en Teotihuacan

    Directory of Open Access Journals (Sweden)

    Salvador Galindo

    2009-01-01

    Full Text Available Al examinar la orientación de trazas urbanas a lo largo de México se puede observar una alineación particular al este de la dirección norte que coincide con la alineación de la antigua ciudad de Teotihuacan. Este trabajo recoge las distintas explicaciones surgidas sobre el origen de esta característica peculiar de Teotihuacan.

  12. Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients

    Czech Academy of Sciences Publication Activity Database

    Závada, Jan; Závadová, Zuzana; Zaťovičová, M.; Hyršl, L.; Kawaciuk, I.

    2003-01-01

    Roč. 89, - (2003), s. 1067-1071 ISSN 0007-0920 R&D Projects: GA ČR GA301/99/0356 Institutional research plan: CEZ:AV0Z5052915 Keywords : carbonic anhydrase IX * tumor antigens * cancer diagnostics Subject RIV: EC - Immunology Impact factor: 3.894, year: 2003

  13. Comparative proteomic analysis of normal and collagen IX null mouse cartilage reveals altered extracellular matrix composition and novel components of the collagen IX interactome.

    Science.gov (United States)

    Brachvogel, Bent; Zaucke, Frank; Dave, Keyur; Norris, Emma L; Stermann, Jacek; Dayakli, Münire; Koch, Manuel; Gorman, Jeffrey J; Bateman, John F; Wilson, Richard

    2013-05-10

    Collagen IX is an integral cartilage extracellular matrix component important in skeletal development and joint function. Proteomic analysis and validation studies revealed novel alterations in collagen IX null cartilage. Matrilin-4, collagen XII, thrombospondin-4, fibronectin, βig-h3, and epiphycan are components of the in vivo collagen IX interactome. We applied a proteomics approach to advance our understanding of collagen IX ablation in cartilage. The cartilage extracellular matrix is essential for endochondral bone development and joint function. In addition to the major aggrecan/collagen II framework, the interacting complex of collagen IX, matrilin-3, and cartilage oligomeric matrix protein (COMP) is essential for cartilage matrix stability, as mutations in Col9a1, Col9a2, Col9a3, Comp, and Matn3 genes cause multiple epiphyseal dysplasia, in which patients develop early onset osteoarthritis. In mice, collagen IX ablation results in severely disturbed growth plate organization, hypocellular regions, and abnormal chondrocyte shape. This abnormal differentiation is likely to involve altered cell-matrix interactions but the mechanism is not known. To investigate the molecular basis of the collagen IX null phenotype we analyzed global differences in protein abundance between wild-type and knock-out femoral head cartilage by capillary HPLC tandem mass spectrometry. We identified 297 proteins in 3-day cartilage and 397 proteins in 21-day cartilage. Components that were differentially abundant between wild-type and collagen IX-deficient cartilage included 15 extracellular matrix proteins. Collagen IX ablation was associated with dramatically reduced COMP and matrilin-3, consistent with known interactions. Matrilin-1, matrilin-4, epiphycan, and thrombospondin-4 levels were reduced in collagen IX null cartilage, providing the first in vivo evidence for these proteins belonging to the collagen IX interactome. Thrombospondin-4 expression was reduced at the mRNA level

  14. Arabidopsis Lectin Receptor Kinases LecRK-IX.1 and LecRK-IX.2 Are Functional Analogs in Regulating Phytophthora Resistance and Plant Cell Death.

    Science.gov (United States)

    Wang, Yan; Cordewener, Jan H G; America, Antoine H P; Shan, Weixing; Bouwmeester, Klaas; Govers, Francine

    2015-09-01

    L-type lectin receptor kinases (LecRK) are potential immune receptors. Here, we characterized two closely-related Arabidopsis LecRK, LecRK-IX.1 and LecRK-IX.2, of which T-DNA insertion mutants showed compromised resistance to Phytophthora brassicae and Phytophthora capsici, with double mutants showing additive susceptibility. Overexpression of LecRK-IX.1 or LecRK-IX.2 in Arabidopsis and transient expression in Nicotiana benthamiana increased Phytophthora resistance but also induced cell death. Phytophthora resistance required both the lectin domain and kinase activity, but for cell death, the lectin domain was not needed. Silencing of the two closely related mitogen-activated protein kinase genes NbSIPK and NbNTF4 in N. benthamiana completely abolished LecRK-IX.1-induced cell death but not Phytophthora resistance. Liquid chromatography-mass spectrometry analysis of protein complexes coimmunoprecipitated in planta with LecRK-IX.1 or LecRK-IX.2 as bait, resulted in the identification of the N. benthamiana ABC transporter NbPDR1 as a potential interactor of both LecRK. The closest homolog of NbPDR1 in Arabidopsis is ABCG40, and coimmunoprecipitation experiments showed that ABCG40 associates with LecRK-IX.1 and LecRK-IX.2 in planta. Similar to the LecRK mutants, ABCG40 mutants showed compromised Phytophthora resistance. This study shows that LecRK-IX.1 and LecRK-IX.2 are Phytophthora resistance components that function independent of each other and independent of the cell-death phenotype. They both interact with the same ABC transporter, suggesting that they exploit similar signal transduction pathways.

  15. Star formation rate in Holmberg IX dwarf galaxy

    Directory of Open Access Journals (Sweden)

    Anđelić M.M.

    2011-01-01

    Full Text Available In this paper we use previously determined Hα fluxes for dwarf galaxy Holmberg IX (Arbutina et al. 2009 to calculate star formation rate (SFR in this galaxy. We discuss possible contaminations of Hα flux and, for the first time, we take into account optical emission from supernova remnants (SNRs as a possible source of contamination of Hα flux. Derived SFR for Holmberg IX is 3:4 x 10-4M.yr-1. Our value is lower then in previous studies, due to luminous shock-heated source M&H 9-10, possible hypernova remnant, which we excluded from the total Hα flux in our calculation of SFR.

  16. Growth stimulation of Porphyromonas endodontalis by hemoglobin and protoporphyrin IX.

    Science.gov (United States)

    Zerr, M A; Cox, C D; Johnson, W T; Drake, D R

    2000-12-01

    Porphyromonas endodontalis, like other Porphyromonas species, has a complex set of nutritional requirements. In addition to being an obligate anaerobe, the bacterium must be grown in a complex medium consisting of amino acids, reducing agents and heme compounds. P. endodontalis accumulates high concentrations of heme pigments to the extent that colonies appear black on blood agar. This accumulation of heme and the need for these compounds has been characterized as iron requirements by these species. However, in our studies, P. endodontalis demonstrated growth dependence on hemoglobin or protoporphyrin IX but not on free iron. Iron added to other heme compounds actually decreased growth stimulation by porphyrin-containing compounds. P. endodontalis actively transported free iron, but this process did not appear to be critical for growth. The maximum stimulation of growth by protoporphyrin IX, under conditions of iron deprivation, suggests that P. endodontalis requires the porphyrin moiety as a growth factor.

  17. Motives and periods in Bianchi IX gravity models

    Science.gov (United States)

    Fan, Wentao; Fathizadeh, Farzad; Marcolli, Matilde

    2018-05-01

    We show that, when considering the anisotropic scaling factors and their derivatives as affine variables, the coefficients of the heat-kernel expansion of the Dirac-Laplacian on SU(2) Bianchi IX metrics are algebro-geometric periods of motives of complements in affine spaces of unions of quadrics and hyperplanes. We show that the motives are mixed Tate and we provide an explicit computation of their Grothendieck classes.

  18. New polymorphic variants of human blood clotting factor IX

    Energy Technology Data Exchange (ETDEWEB)

    Surin, V.L.; Luk`yanenko, A.V.; Tagiev, A.F.; Smirnova, O.V. [Hematological Research Center, Moscow (Russian Federation); Plutalov, O.V.; Berlin, Yu.A. [Shemyakin Institute of Bioorganic Chemistry, Moscow (Russian Federation)

    1995-04-01

    The polymorphism of Alu-repeats, which are located in the introns of the human factor IX gene (copies 1-3), was studied. To identify polymorphic variants, direct sequencing of PCR products that contained appropriate repeats was used. In each case, 20 unrelated X chromosomes were studied. A polymorphic Dra I site was found near the 3{prime}-end of Alu copy 3 within the region of the polyA tract. A PCR-based testing system with internal control of restriction hydrolysis was suggested. Testing 81 unrelated X chromosomes revealed that the frequency of the polymorphic Dra I site is 0.23. Taq I polymorphism, which was revealed in Alu copy 4 of factor IX gene in our previous work, was found to be closely linked to Dra I polymorphism. Studies in linkage between different types of polymorphisms of the factor IX gene revealed the presence of a rare polymorphism in intron a that was located within the same minisatellite region as the known polymorphic insertion 50 bp/Dde I. However, the size of the insertion in our case was 26 bp. Only one polymorphic variant was found among over 150 unrelated X chromosomes derived from humans from Moscow and its vicinity. 10 refs., 4 figs., 1 tab.

  19. Loop quantum cosmology of Bianchi IX: effective dynamics

    International Nuclear Information System (INIS)

    Corichi, Alejandro; Montoya, Edison

    2017-01-01

    We study solutions to the effective equations for the Bianchi IX class of spacetimes within loop quantum cosmology (LQC). We consider Bianchi IX models whose matter content is a massless scalar field, by numerically solving the loop quantum cosmology effective equations, with and without inverse triad corrections. The solutions are classified using certain geometrically motivated classical observables. We show that both effective theories—with lapse N   =   V and N   =  1—resolve the big bang singularity and reproduce the classical dynamics far from the bounce. Moreover, due to the positive spatial curvature, there is an infinite number of bounces and recollapses. We study the limit of large field momentum and show that both effective theories reproduce the same dynamics, thus recovering general relativity. We implement a procedure to identify amongst the Bianchi IX solutions, those that behave like k   =  0,1 FLRW as well as Bianchi I, II, and VII 0 models. The effective solutions exhibit Bianchi I phases with Bianchi II transitions and also Bianchi VII 0 phases, which had not been studied before. We comment on the possible implications of these results for a quantum modification to the classical BKL behaviour. (paper)

  20. Spectral action for Bianchi type-IX cosmological models

    International Nuclear Information System (INIS)

    Fan, Wentao; Fathizadeh, Farzad; Marcolli, Matilde

    2015-01-01

    A rationality result previously proved for Robertson-Walker metrics is extended to a homogeneous anisotropic cosmological model, namely the Bianchi type-IX minisuperspace. It is shown that the Seeley-de Witt coefficients appearing in the expansion of the spectral action for the Bianchi type-IX geometry are expressed in terms of polynomials with rational coefficients in the cosmic evolution factors w_1(t),w_2(t),w_3(t), and their higher derivates with respect to time. We begin with the computation of the Dirac operator of this geometry and calculate the coefficients a_0,a_2,a_4 of the spectral action by using heat kernel methods and parametric pseudodifferential calculus. An efficient method is devised for computing the Seeley-de Witt coefficients of a geometry by making use of Wodzicki’s noncommutative residue, and it is confirmed that the method checks out for the cosmological model studied in this article. The advantages of the new method are discussed, which combined with symmetries of the Bianchi type-IX metric, yield an elegant proof of the rationality result.

  1. Loop quantum cosmology of Bianchi IX: effective dynamics

    Science.gov (United States)

    Corichi, Alejandro; Montoya, Edison

    2017-03-01

    We study solutions to the effective equations for the Bianchi IX class of spacetimes within loop quantum cosmology (LQC). We consider Bianchi IX models whose matter content is a massless scalar field, by numerically solving the loop quantum cosmology effective equations, with and without inverse triad corrections. The solutions are classified using certain geometrically motivated classical observables. We show that both effective theories—with lapse N  =  V and N  =  1—resolve the big bang singularity and reproduce the classical dynamics far from the bounce. Moreover, due to the positive spatial curvature, there is an infinite number of bounces and recollapses. We study the limit of large field momentum and show that both effective theories reproduce the same dynamics, thus recovering general relativity. We implement a procedure to identify amongst the Bianchi IX solutions, those that behave like k  =  0,1 FLRW as well as Bianchi I, II, and VII0 models. The effective solutions exhibit Bianchi I phases with Bianchi II transitions and also Bianchi VII0 phases, which had not been studied before. We comment on the possible implications of these results for a quantum modification to the classical BKL behaviour.

  2. Spectral action for Bianchi type-IX cosmological models

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Wentao; Fathizadeh, Farzad; Marcolli, Matilde [Division of Physics, Mathematics and Astronomy, California Institute of Technology,1200 E. California Blvd., Pasadena, CA 91125 (United States)

    2015-10-13

    A rationality result previously proved for Robertson-Walker metrics is extended to a homogeneous anisotropic cosmological model, namely the Bianchi type-IX minisuperspace. It is shown that the Seeley-de Witt coefficients appearing in the expansion of the spectral action for the Bianchi type-IX geometry are expressed in terms of polynomials with rational coefficients in the cosmic evolution factors w{sub 1}(t),w{sub 2}(t),w{sub 3}(t), and their higher derivates with respect to time. We begin with the computation of the Dirac operator of this geometry and calculate the coefficients a{sub 0},a{sub 2},a{sub 4} of the spectral action by using heat kernel methods and parametric pseudodifferential calculus. An efficient method is devised for computing the Seeley-de Witt coefficients of a geometry by making use of Wodzicki’s noncommutative residue, and it is confirmed that the method checks out for the cosmological model studied in this article. The advantages of the new method are discussed, which combined with symmetries of the Bianchi type-IX metric, yield an elegant proof of the rationality result.

  3. Effect of 5-aminolevulinic acid on kinetics of protoporphyrin IX production in CHO cells.

    Directory of Open Access Journals (Sweden)

    W Warchoł

    2004-07-01

    Full Text Available 5-aminolevulinic acid (ALA is utilized in a photodynamic therapy as a compound capable of augmenting intracellular pool of protoporphyrin IX (PpIX, which exhibits properties of a photosensitizer. The studies were aimed at monitoring accumulation of endogenous protoporphyrin IX in CHO cells under effect of various concentrations of ALA in culture medium and following removal of the compound from the culture medium. Cell content of PpIX was determined following incubation of the cells for 72 h in a culture medium containing different concentration of ALA. Moreover, the cells were preincubated for 2 h in ALA at various concentrations and separated from the compound by medium change and their PpIX content was monitored following incubation. PpIX content was defined by a fluorescent technique under the confocal microscope. In the course of continuous incubation of cells with ALA, biphasic alterations were noted in cellular PpIX concentration. Removal of ALA from the incubation medium resulted at first in a decrease in PpIX content in cells, which was followed by an evidently augmented accumulation of the compound in the cells. The results suggested that in the case of CHO cells, exogenous ALA was not an exclusive source of PpIX synthesis and that alterations in enzyme activities were responsible for production of PpIX.

  4. Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors.

    Science.gov (United States)

    Ditte, Peter; Dequiedt, Franck; Svastova, Eliska; Hulikova, Alzbeta; Ohradanova-Repic, Anna; Zatovicova, Miriam; Csaderova, Lucia; Kopacek, Juraj; Supuran, Claudiu T; Pastorekova, Silvia; Pastorek, Jaromir

    2011-12-15

    In the hypoxic regions of a tumor, carbonic anhydrase IX (CA IX) is an important transmembrane component of the pH regulatory machinery that participates in bicarbonate transport. Because tumor pH has implications for growth, invasion, and therapy, determining the basis for the contributions of CA IX to the hypoxic tumor microenvironment could lead to new fundamental and practical insights. Here, we report that Thr443 phosphorylation at the intracellular domain of CA IX by protein kinase A (PKA) is critical for its activation in hypoxic cells, with the fullest activity of CA IX also requiring dephosphorylation of Ser448. PKA is activated by cAMP, which is elevated by hypoxia, and we found that attenuating PKA in cells disrupted CA IX-mediated extracellular acidification. Moreover, following hypoxia induction, CA IX colocalized with the sodium-bicarbonate cotransporter and other PKA substrates in the leading edge membranes of migrating tumor cells, in support of the concept that bicarbonate metabolism is spatially regulated at cell surface sites with high local ion transport and pH control. Using chimeric CA IX proteins containing heterologous catalytic domains derived from related CA enzymes, we showed that CA IX activity was modulated chiefly by the intracellular domain where Thr443 is located. Our findings indicate that CA IX is a pivotal mediator of the hypoxia-cAMP-PKA axis, which regulates pH in the hypoxic tumor microenvironment.

  5. Precio y manejo del agua urbana en México

    Directory of Open Access Journals (Sweden)

    Gregorio Castro Rosales

    2015-01-01

    Full Text Available Este trabajo propone evaluar el potencial del precio que pagan los usuarios como ins - trumento para el manejo de la demanda urbana de agua en México. Nuestros resulta - dos basados en un análisis de datos provenientes de cientos de organismos operadores de agua potable del país, revelan que la demanda de agua sí es sensible al precio, tal y como se ha señalado en otros estudios. No obstante, encontramos también que la demanda es aún mucho más sensible al efecto del crecimiento poblacional y económi - co. Por lo tanto, considerando la dinámica demográfica, urbana y económica del país, un aumento en el precio del agua en sí no podría contribuir significativamente a la estabilización de los requerimientos nacionales de extracción de agua para uso urbano. Además, nuestro análisis de los determinantes del precio del agua urbana revela que los organismos operadores pasan sistemáticamente el costo de sus ineficiencias técnicas y financieras a los usuarios, por lo que un aumento en el precio del agua tampoco podría contribuir al saneamiento de sus finanzas. Concluimos que para un manejo efectivo, eficiente y sustentable del uso urbano de agua, resulta imprescindible un cambio de fondo en la manera en que operan los sistemas urbanos de agua.

  6. Entre ritmo e poesia: rap e literatura oral urbana

    Directory of Open Access Journals (Sweden)

    Marcus Rogerio Salgado

    2015-11-01

    Full Text Available O objetivo do presente artigo é um estudo do rap enquanto manifestação de literatura oral urbana e forma de oralidade tecnológica. Para tanto, o artigo passará em revista as relações entre literatura e palavra falada/cantada, assim como as possibilidades de interface estética entre a literatura e a música que estão em questão quando tratamos do rap.

  7. Three nucleon results for one boson exchange potential

    International Nuclear Information System (INIS)

    Birrell, N.D.; Afnan, I.R.

    1977-06-01

    The binding energy of 3 H, percentage S-, S'-, and D-state probabilities and charge form factor of 3 He are calculated using the Adhikari-Sloan separable expansion (ASE) to the Holinde and Machleidt one boson exchange potential. The results show that the ASE has good convergence for the binding energy, and the lowest order ASE considered gives excellent results for the form factor. (Author)

  8. P-matrix approach and three-nucleon problem

    International Nuclear Information System (INIS)

    Babenko, V.A.; Petrov, N.M.; Teneva, G.N.

    1993-01-01

    The paper deals with the P-matrix approach application to the three strongly interacting particles systems description. On the basis of the obtained off-energy-shell scattering amplitude separable expansion in the P-matrix approach the low-energy three-particle quantities were calculated in the case of square-well potential. The results of calculations show good convergence of the calculated three-particle quantities. (author). 12 refs., 1 tab

  9. Presentación al dossier de Historia Urbana

    Directory of Open Access Journals (Sweden)

    Jairo Antonio Melo Flórez

    2013-12-01

    Full Text Available Presentamos la sexta edición de nuestra publicación, esta vez con el tema central enfocado en la Historia Urbana, temática que, como esperábamos, tuvo gran acogida por parte de investigadores en todos los niveles de formación y de varias instituciones académicas latinoamericanas. El resultado no podía ser otro ya que cientos de investigadores de todo el mundo se dedican a esta especialidad de la historia. El tema de la Ciudad adquiere cada vez mayor importancia, si se tiene en cuenta la gran cantidad de temáticas susceptibles de ser abordadas por este enfoque disciplinar y más aún cuando los problemas de las urbes a nivel global y sobre todo a nivel latinoamericano, están tan vigentes. Este número quiere ser un aporte, un grano de arena más que se suma a la inmensa producción académica referente a la historia urbana, esperando con ello generar conocimiento que aporte en alguna medida a la solución de los fenómenos adversos que afronta los habitantes de la ciudad actual, tales como: pobreza, marginalidad, segregación, errores de planificación y dificultades de acceso a la vivienda, por nombrar sólo algunos.

  10. Origen y formación de una villa de repoblación. Benavente durante los reinados de Fernando II y Alfonso IX

    Directory of Open Access Journals (Sweden)

    Rafael GONZÁLEZ RODRÍGUEZ

    2009-12-01

    Full Text Available RESUMEN: Durante los reinados de Fernando II y Alfonso IX asistimos a un ambicioso proyecto de repoblación urbana, coincidiendo con el período de separación política entre los reinos de León y Castilla. Este proceso tuvo como resultado el establecimiento de nuevas villas, en buena parte de los casos herederas de los antiguos "castros" y "castellos" altomedievales. La repoblación de Benavente, inscrita dentro de este contexto histórico, se realizó a partir de un núcleo preurbano anterior: el "castrum" de Malgrad, organizando un vasto territorio que se extendía por buena parte del norte de la actual provincia de Zamora, configurándose así como uno de los concejos más extensos al norte del río Duero.ABSTRACT: During the reigns of King Fernando II and King Alfonso IX we witness an ambitious initiative of urban repopulation, coinciding with the period of political separation between the Kingdoms of Castile and León. This process resulted in the establishment of new villages, in many cases originating from ancient "castros" and "castellos" from the high Middle Ages. The repopulation of Benavente, integrated in this historical context, was formed from a previous pre—urban nucleus: the "castrum" of Malgrad, organizing a vast territory that extended mainly in the northern part of fhc present province of Zamora, establishing itself as one of the most extensive councils to the north of the Duero River.

  11. The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis.

    Science.gov (United States)

    Mahon, Brian P; Bhatt, Avni; Socorro, Lilien; Driscoll, Jenna M; Okoh, Cynthia; Lomelino, Carrie L; Mboge, Mam Y; Kurian, Justin J; Tu, Chingkuang; Agbandje-McKenna, Mavis; Frost, Susan C; McKenna, Robert

    2016-08-23

    Human carbonic anhydrase IX (hCA IX) expression in many cancers is associated with hypoxic tumors and poor patient outcome. Inhibitors of hCA IX have been used as anticancer agents with some entering Phase I clinical trials. hCA IX is transmembrane protein whose catalytic domain faces the extracellular tumor milieu, which is typically associated with an acidic microenvironment. Here, we show that the catalytic domain of hCA IX (hCA IX-c) exhibits the necessary biochemical and biophysical properties that allow for low pH stability and activity. Furthermore, the unfolding process of hCA IX-c appears to be reversible, and its catalytic efficiency is thought to be correlated directly with its stability between pH 3.0 and 8.0 but not above pH 8.0. To rationalize this, we determined the X-ray crystal structure of hCA IX-c to 1.6 Å resolution. Insights from this study suggest an understanding of hCA IX-c stability and activity in low-pH tumor microenvironments and may be applicable to determining pH-related effects on enzymes.

  12. Embryonic chicken cornea and cartilage synthesize type IX collagen molecules with different amino-terminal domains.

    OpenAIRE

    Svoboda, K K; Nishimura, I; Sugrue, S P; Ninomiya, Y; Olsen, B R

    1988-01-01

    We have analyzed embryonic chicken cornea for the presence of type IX collagen mRNA and protein. Using RNA transfer blot analysis, we demonstrate that alpha 1(IX) and alpha 2(IX) mRNAs are expressed by corneal epithelial cells at the time that the primary stromal components are synthesized. The levels of the mRNAs decrease with increasing developmental age and are barely detectable at day 11 of development. In contrast, type IX collagen protein is detectable by immunofluorescence at days 5 an...

  13. The spectroscopy analyses of PpIX by ultrasound irradiation and its sonotoxicity in vitro.

    Science.gov (United States)

    Wang, Pan; Wang, Xiaobing; Zhang, Kun; Gao, Kaili; Song, Ming; Liu, Quanhong

    2013-07-01

    Protoporphyrin IX (PpIX) has been used as a sensitizer in photodynamic therapy (PDT) as well as in sonodynamic therapy (SDT). The photo-bleaching of PpIX has been well investigated in many experimental systems and some photo-products have also been identified in PDT. But until now, little information has been reported about the sono-damage of PpIX in SDT. So, the present study was to investigate changes of PpIX properties before and after different ultrasound treatment, and the potential interactions between PpIX, ultrasound and the irradiated cells. In cell-free system, the absorption and fluorescence spectra of PpIX in different solutions were measured by ultraviolet spectrometer and fluorescence spectrophotometer, respectively. The terephthalic acid dosimetry was applied to evaluate the efficiency of ultrasound cavitation by monitoring hydroxyl radical (OH) production on the thermolysis of H2O in the ultrasound field. In in vitro study, confocal microscopy was applied to detect the sub-cellular localization of PpIX in S180 cells before and after ultrasound exposure. Flow cytometry was used to detect the reactive oxygen species (ROS) generation during PpIX-SDT. MTT assay was performed to evaluate the cell viability of S180 cells after SDT treatment with or without ROS scavengers. The results show that PpIX displayed different spectral patterns in different solutions. PpIX was decomposed by ultrasound exposure as measured by the decreased absorption and fluorescence peak values in RPMI-1640 medium. In addition, the decomposition of PpIX was found to be simultaneously accompanied by OH production with increasing output power from ultrasound generator. PpIX at 1μg/ml significantly enhanced the ultrasound induced cavitation as measured by OH generation, and which was greatly eliminated by NaN3, histidine, mannitol, EDTA and catalase, but not by SOD. The in vitro study indicates more PpIX entered into S180 cells after ultrasound exposure. And, the extra-cellular PpIX

  14. Noninvasive murine glioma detection improved following photobleaching of skin PpIX fluorescence

    Science.gov (United States)

    Gibbs-Strauss, Summer L.; Davis, Scott C.; O'Hara, Julia A.; Hoopes, P. Jack; Hasan, Tayyaba; Pogue, Brian W.

    2008-02-01

    Aminolevulinic Acid (ALA) is a prodrug which can be administered to cells, animals or patients after which it is transformed via the Heme synthesis pathway into the fluorescent molecule Protoporphyrin IX (PpIX). PpIX has been shown to be useful as both a photosensitizer for photodynamic therapy (PDT) and as a fluorescence imaging contrast agent. The ALA-PpIX system not only provides contrast for fluorescence imaging but also gives information about the metabolic activity of the imaged tissue and thus could be useful for monitoring cancer therapy. In the current study skin photobleaching was examined to determine if PpIX fluorescence contrast in malignant brain tumors could be better visualized noninvasively. Red light photobleaching decreased skin PpIX fluorescence and increased the ability to noninvasively quantify PpIX fluorescence in murine gliomas, as in vivo measurements of mean PpIX fluorescence more closely matched ex vivo quantification following skin photobleaching. Three doses of blue light photobleaching (4 J/cm2, 8 J/cm2 and 12 J/cm2) were tested and determined to give similar levels of skin photobleaching as well as a similar window of decreased skin PpIX fluorescence for noninvasive fluorescence imaging following the photobleaching dose administration.

  15. Variability of in vivo recovery of factor IX after infusion of monoclonal antibody purified factor IX concentrates in patients with hemophilia B. The Mononine Study Group.

    Science.gov (United States)

    White, G C; Shapiro, A D; Kurczynski, E M; Kim, H C; Bergman, G E

    1995-05-01

    Monoclonal antibody purified factor IX concentrate, Mononine (Armour Pharmaceutical Company, Kankakee, Illinois, USA), is a recently developed replacement factor concentrate for the treatment of patients with hemophilia B. The pharmacokinetic properties of monoclonal antibody purified factor IX concentrate (MAb Factor IX concentrate) have been evaluated in only small samples of patients, and little is known about those factors that might influenced in vivo recovery of factor IX after infusion is a larger patient population. In vivo recovery of factor IX was therefore evaluated for 80 different indications in 72 patients who received MAb Factor IX concentrate for the management of spontaneous or trauma-induced bleeding, or as prophylaxis with surgery. The average recovery after infusions for presurgical pharmacokinetic analysis (mean +/- standard deviation) was 1.28 +/- 0.56 U/dl rise per U/kg infused (range 0.41-2.80), and the average recovery after all infusions for treatment was 1.23 +/- 0.49 U/dl rise per U/kg infused (range - 0.35-2.92). Recovery values for multiple MAb Factor IX doses in a given patient were also variable; the average recovery was 1.22 +/- 0.53 U/dl rise per U/kg given, and standard deviations ranged from 0.03 to 1.26. Patient age, weight, and MAb Factor IX concentrate dose minimally but significantly influenced factor IX recovery. There was no significant effect of either race, history of previous thrombotic complications during treatment with other replacement factor concentrates, or bleeding state on recovery. All of the patients treated with this preparation experienced excellent hemostasis, and no thrombotic complications were observed.

  16. Immunosuppressive effects of factor IX products: an in vitro study.

    Science.gov (United States)

    Grosset, A B; McGregor, J R; Samlowski, W E; Rodgers, G M

    1999-11-01

    The effects of a recombinant factor IX product (BeneFix), and of five plasma-derived factor IX products, AlphaNine, Immunine, Konyne, Mononine and Replinine on in vitro peripheral blood mononuclear cell (PBMC) immune function were compared in a blinded study. We assessed the effects of these products on Con-A-induced lymphocyte proliferation and interleukin-2 and interleukin-10 secretion, expression of lymphocyte activation markers, and nitric oxide secretion by stimulated mouse peritoneal macrophages. At 1 mL-1 for 48 h, Konyne reduced Con-A-induced mitogenesis by 50% (P < 0.05); AlphaNine, Mononine and BeneFix had no effect. At 10 IU mL-1, Con-A-induced mi- togenesis was at control levels with Mononine and BeneFix, but was reduced to <15% (P < 0.05) with each of the other products. IL-2 and IL-10 secretion by Con-A-stimulated lymphocytes was also markedly depressed by all the products tested except Mononine and BeneFix. Dialysis of these products did not substantially affect these results. Flow cytometric analysis of lymphocyte activation markers following Con-A stimulation showed that Konyne also decreased IL-2 receptor alpha and beta chain (CD25 and CD122) induction on PBMC. Konyne also inhibited nitric oxide secretion to levels <18% of controls. These results indicate that certain factor IX products, including some of purported higher purity, substantially depress in vitro immune function. The importance of these findings to in vivo immune function in haemophilia B patients remains to be established.

  17. Drenagem urbana sustentável : análise do uso do retrofit

    OpenAIRE

    Christofidis, Hugo do Vale

    2013-01-01

    A presente dissertação demonstrou que a drenagem urbana sustentável é uma componente importante na busca da sustentabilidade do ambiente urbano e que o Retrofit é uma ferramenta eficiente para alcançar esse objetivo. Para tanto foi apresentada uma metodologia de Retrofit de infraestrutura urbana que permite adaptar sistemas de drenagem urbana tradicionais em sistemas sustentáveis. Essa metodologia foi desenvolvida por uma organização não-governamental (ONG) americana e foram propostas algumas...

  18. Fe IX CALCULATIONS FOR THE SOLAR DYNAMICS OBSERVATORY

    International Nuclear Information System (INIS)

    Foster, Adam R.; Testa, Paola

    2011-01-01

    New calculations of the energy levels, radiative transition rates, and collisional excitation rates of Fe IX have been carried out using the Flexible Atomic Code, paying close attention to experimentally identified levels and extending existing calculations to higher energy levels. For lower levels, R-matrix collisional excitation rates from earlier work have been used. Significant emission is predicted by these calculations in the 5f-3d transitions, which will impact analysis of Solar Dynamics Observatory Atmospheric Imaging Assembly observations using the 94 A filter.

  19. The Bianchi IX model in loop quantum cosmology

    International Nuclear Information System (INIS)

    Bojowald, Martin; Date, Ghanashyam; Hossain, Golam Mortuza

    2004-01-01

    The Bianchi IX model has been used often to investigate the structure close to singularities of general relativity. Its classical chaos is expected to have, via the BKL scenario, implications even for the approach to general inhomogeneous singularities. Thus, it is a popular model to test consequences of modifications to general relativity suggested by quantum theories of gravity. This paper presents a detailed proof that modifications coming from loop quantum gravity lead to a non-chaotic effective behaviour. The way this is realized, independently of quantization ambiguities, suggests a new look at initial and final singularities

  20. Polilinguismo nella scrittura murale urbana: Note sulla lingua spagnola

    Directory of Open Access Journals (Sweden)

    ELena Landone

    2016-01-01

    Full Text Available Abstract – In this paper I focus on the polylinguistic and polycultural landscape of Milan on the theoretical basis of daily life studies, the sociolinguistics of globalization, and intercultural pragmatics. The relevance of this field is determined by the need for urban anthropology to semiotize the urban spaces as an interpretative bridge between the microsystem (the individual level and the macrosystem (the social level. More concretely, I investigate the presence of the Spanish language in the superdiversity of Milan and, methodologically, I collect ethnographically and interpret qualitatively a corpus of 700 daily life texts of various types of street writing. The results show the significant presence of Spanish in the urban landscape and a high level of hybridism which is, nevertheless, totally functional in communication. I also detect the emergence of linguistic, pragmatic and intercultural awareness in the writers. Finally, with some precautions, I confirm the scientific potential of the daily life documents to investigate complex urban dynamics.Resumen – El tema de este estudio es el panorama polilingüe y policultural de Milán y se plantea a partir de las bases teóricas de los everyday life studies, de la sociolingüistica de la globalización y de la pragmática intercultural. La relevancia del estudio descansa en la necesidad de la antropología urbana de elaborar una interpretación semiótica de los espacios urbanos, puesto que pueden constituir un puente interpretativo entre el microsistema (individuo y el macrosistema (sociedad. Concretamente, el objetivo es investigar el papel del idioma español en la supediversidad milanesa; la metodología es de etnografía urbana con la formación e interpretación cualitativa de un corpus fotográfico de setecientos textos cotidianos de escritura callejera (pintadas, avisos, grafiti, ecc.. Los datos relevan una presencia significativa del español en el landscape milanés, con un

  1. Effect of IX dosing on polypropylene and PVDF membrane fouling control

    KAUST Repository

    Myat, Darli Theint

    2013-07-01

    The performance of ion exchange (IX) resin for organics removal from wastewater was assessed using advanced characterisation techniques for varying doses of IX. Organic characterisation using liquid chromatography with a photodiode array (PDA) and fluorescence spectroscopy (Method A), and UV254, organic carbon and organic nitrogen detectors (Method B), was undertaken on wastewater before and after magnetic IX treatment. Results showed partial removal of the biopolymer fraction at high IX doses. With increasing concentration of IX, evidence for nitrogen-containing compounds such as proteins and amino acids disappeared from the LC-OND chromatogram, complementary to the fluorescence response. A greater fluorescence response of tryptophan-like proteins (278nm/343nm) for low IX concentrations was consistent with aggregation of tryptophan-like compounds into larger aggregates, either by self-aggregation or with polysaccharides. Recycling of IX resin through multiple adsorption steps without regeneration maintained the high level of humics removal but there was no continued removal of biopolymer. Subsequent membrane filtration of the IX treated waters resulted in complex fouling trends. Filtration tests with either polypropylene (PP) or polyvinylidene fluoride (PVDF) membranes showed higher rates of initial fouling following treatment with high IX doses (10mL/L) compared to filtration of untreated water, while treatment with lower IX doses resulted in decreased fouling rates relative to the untreated water. However, at longer filtration times the rate of fouling of IX treated waters was lower than untreated water and the relative fouling rates corresponded to the amount of biopolymer material in the feed. It was proposed that the mode of fouling changed from pore constriction during the initial filtration period to filter cake build up at longer filtration times. The organic composition strongly influenced the rate of fouling during the initial filtration period due to

  2. Aproximación a la silvicultura urbana en colombia

    OpenAIRE

    Tovar-Corso, Germán

    2013-01-01

    Este artículo revisa los antecedentes y adelantos que en materia de Silvicultura Urbana se han realizado en Colombia en el pasado reciente y presenta un análisis de la situación actual del tema sustentado en los resultados obtenidos de la aplicación de una encuesta a las autoridades ambientales del país con el fin de aproximar un diagnóstico que tiene en cuenta aspectos de orden técnico, administrativo y jurídico con los cuales se realiza actualmente la gestión y el manejo del árbol en las ár...

  3. A grande aventura urbana The great urban adventure

    Directory of Open Access Journals (Sweden)

    Ângela Freire Prysthon

    2008-11-01

    Full Text Available Caiafa, Janice (2007. Aventura das cidades. ensaios e etnografias. Rio de Janeiro: Editora FGV. Em Aventura das cidades, Janice Caiafa reúne oito ensaios apresentados e publicados nos últimos anos. O tema central de sete deles é justamente a experiência urbana e a errância pelas metrópoles contemporâneas, o último traz à tona as questões metodológicas que permeiam as etnografias das cidades feitas pela autora. In Adventure of the Cities, Janice Caiafa compiles eight essays presented and published in recent years. The central theme of seven of these essays is, as indicated by the title, the urban experience and wandering through contemporary metropolises. The eighth essay broaches methodological issues that permeate the author's ethnographies of the city.

  4. CLIMATOLOGÍA URBANA Y DE MONTAÑAS

    Directory of Open Access Journals (Sweden)

    CARLOS ALBERTO PALACIO

    2012-01-01

    Full Text Available Este artículo tiene por objeto presentar en líneas muy gruesas el estado de las investigaciones sobre las condiciones de clima en las ciudades, haciendo un énfasis mayor en las condiciones urbanas de montaña. La investigación de la meteorología para los centros urbanos reclama con urgencia la atención de la sociedad colombiana, debido a la creciente concentración de población en ellos, a los serios problemas de salud asociados con deficientes condiciones de calidad del aire y al rezago de las instituciones gubernamentales en relación con la evaluación, entendimiento y gestión de los procesos atmosféricos que afectan la vida en las ciudades. Los retos son inmensos, y en varios casos ameritan un trabajo interdisciplinario y de colaboración internacional.

  5. Mesa redonda: en torno a la calidad de vida urbana

    OpenAIRE

    Roberto Lira Olmo

    2002-01-01

    Para el presente número de la Revista Urbano, el Comité Editorial de la misma estimó de gran interés por la vigencia e importancia que el tema reviste, dedicar un número especial para tratar los variados aspectos que tocan a la calidad de vida urbana, entendida ésta no sólo como una relación de indicadores cuantitativos de pobreza, educación, salud medio ambiente e infraestructuras, sino que como el carácter que las ciudades tienen respecto del modo de sentirse cómodos y satisfechos sus habit...

  6. Mesa redonda: en torno a la calidad de vida urbana

    Directory of Open Access Journals (Sweden)

    Roberto Lira Olmo

    2002-08-01

    Full Text Available Para el presente número de la Revista Urbano, el Comité Editorial de la misma estimó de gran interés por la vigencia e importancia que el tema reviste, dedicar un número especial para tratar los variados aspectos que tocan a la calidad de vida urbana, entendida ésta no sólo como una relación de indicadores cuantitativos de pobreza, educación, salud medio ambiente e infraestructuras, sino que como el carácter que las ciudades tienen respecto del modo de sentirse cómodos y satisfechos sus habitantes en ella.

  7. 5-ALA/PpIX fluorescence detection of gastrointestinal neoplasia

    Science.gov (United States)

    Borisova, Ekaterina G.; Vladimirov, Borislav; Terziev, Ivan; Ivanova, Radina; Avramov, Latchezar

    2009-07-01

    In the recent study delta-ALA/PpIX is used as fluorescent marker for dysplasia and tumor detection in esophagus, stomach and colon. ALA is administered per os six to eight (depending on the lesion location) hours before measurements at dose 20mg/kg weight. High-power light-emitting diode at 405 nm is used as an excitation source. Special opto-mechanical device is built for the LED to use the light guide of standard video-endoscopic system. Through endoscopic instrumental channel a fiber is applied to return information about fluorescence to microspectrometer. The fluorescence detected from tumor sites has very complex spectral origins. It consists of autofluorescence, fluorescence from exogenous fluorophores and re-absorption from the chromophores accumulated in the tissue investigated. Spectral features observed during endoscopic investigations could be distinct as the next regions: 450-630 nm region, where tissue autofluorescence is observed; 630-710 nm region, where fluorescence of PpIX is clearly pronounced; 530-580 nm region, where minima in the autofluorescence signal are observed, related to re-absorption of oxy-hemoglobin in this spectral area. Endogenous and exogenous fluorescence spectra are used to develop simple but effective algorithm, based on dimensionless ratio of the signals at 560 and 635 nm, for differentiation of normal/abnormal gastrointestinal tissues. Very good correlation between fluorescence signals and histology examination of the lesions investigated is achieved.

  8. A Place on the Team: The Triumph and Tragedy of Title IX

    Science.gov (United States)

    Suggs, Welch

    2006-01-01

    "A Place on the Team" is the inside story of how Title IX revolutionized American sports. The federal law guaranteeing women's rights in education, Title IX opened gymnasiums and playing fields to millions of young women previously locked out. Journalist Welch Suggs chronicles both the law's successes and failures-the exciting…

  9. Why, What and Where To? Title IX, Educational Amendment of 1972.

    Science.gov (United States)

    Perry-Miller, Mitzi

    Three years after Title IX of the Education Amendments of 1972 became law, the U. S. Department of Health, Education, and Welfare provided regulations for the implementation of Title IX. This report reviews the implications of these regulations as well as several of the court cases in which discrimination on the basis of sex has been declared…

  10. Not Second-Class: Title IX, Equity, and Girls' High School Sports

    Science.gov (United States)

    Stader, David L.; Surface, Jeanne L.

    2014-01-01

    Title IX is designed to protect students from discrimination based on sex in any educational institution that receives financial assistance. This article focuses on Title IX as it applies to high school athletic programs by considering the trial of a high school district in California. A federal court found considerable inequalities between boys…

  11. The feasibility of using concentrates containing factor IX for continuous infusion.

    Science.gov (United States)

    Schulman, S; Gitel, S; Zivelin, A; Katsarou, O; Mandalaki, T; Varon, D; Martinowitz, U

    1995-04-01

    We have investigated the feasibility of continuous infusion of undiluted factor IX (F IX) over several days using minipumps. The stabilities of seven different reconstituted F IX products were substantially better than those declared by the manufacturers. Several concentrates maintained factor activities 80% of baseline for the entire period of 4 weeks at 4-8d̀C as did one product at 20-23d̀A. At 37d̀C the latter concentrate was stable for at least 1 week. The stability seemed to correlate with the purity of the product. Analysis of two prothrombin comples concentrates by gel electrophoresis demonstrated degradation of prothrombin to prethrombin-1 and fragment 1 at 37d̀C and in one of the concentrates also at 20-23d̀C. In two F IX concentrates the corresponding analysis did not reveal any degradation. Four patients were treated with continuous infusion with a pure F IX concentrate (Mononine™, Armour) after surgery or for serious haemorrhage (two each) with good haemostatic effect, an initial progressive decrease of the F IX clearance, and no side-effects. Continuous infusion with F IX, using a minipump and undiluted reconstituted factor, is therefore feasible and effective, and can be conveniently prepared for several days at a time. Pure F IX products are more stable and probably safer for this purpose.

  12. An update on anticancer drug development and delivery targeting carbonic anhydrase IX

    Directory of Open Access Journals (Sweden)

    Justina Kazokaitė

    2017-11-01

    Full Text Available The expression of carbonic anhydrase (CA IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse the acidic environment of solid tumors and reduce the tumor growth establishing the significant role of CA IX in tumorigenesis. Thus, the development of potent antitumor drugs targeting CA IX with minimal toxic effects is important for the target-specific tumor therapy. Recently, several promising antitumor agents against CA IX have been developed to treat certain types of cancers in combination with radiation and chemotherapy. Here we review the inhibition of CA IX by small molecule compounds and monoclonal antibodies. The methods of enzymatic assays, biophysical methods, animal models including zebrafish and Xenopus oocytes, and techniques of diagnostic imaging to detect hypoxic tumors using CA IX-targeted conjugates are discussed with the aim to overview the recent progress related to novel therapeutic agents that target CA IX in hypoxic tumors.

  13. On the role of type IX collagen in the extracellular matrix of cartilage: type IX collagen is localized to intersections of collagen fibrils

    OpenAIRE

    1986-01-01

    The tissue distribution of type II and type IX collagen in 17-d-old chicken embryo was studied by immunofluorescence using polyclonal antibodies against type II collagen and a peptic fragment of type IX collagen (HMW), respectively. Both proteins were found only in cartilage where they were co-distributed. They occurred uniformly throughout the extracellular matrix, i.e., without distinction between pericellular, territorial, and interterritorial matrices. Tissues that undergo endochondral bo...

  14. 4p-5s transitions in YVII, VIII, ZrVIII, IX, NbIX, X and MoX, XI

    International Nuclear Information System (INIS)

    Rahimullah, K.; Chaghtai, M.S.Z.; Khatoon, S.

    1976-01-01

    The spectra of Y VII, VIII, Zr VIII, IX, Nb X and Mo X, XI are studied for the first time and the 1971 analysis of Nb IX is improved. By analyses of the transitions 4s 2 4psup(k)-4s 2 4psup(k-1)5s all the levels of the configurations 4p 3 , 4p 2 5s, 4p 2 and 4p5s are established in the spectra concerned. (Auth.)

  15. Functional consequences of an arginine180 to glutamine mutation in factor IX Hilo.

    Science.gov (United States)

    Monroe, D M; McCord, D M; Huang, M N; High, K A; Lundblad, R L; Kasper, C K; Roberts, H R

    1989-05-01

    Factor IX Hilo is a variant factor IX molecule that has no detectable coagulant activity. The defect in factor IX Hilo arises from a point mutation in the gene such that in the protein Arg180 is converted to a Gln. Activation of factor IX Hilo by factor Xla was monitored using the fluorescent active site probe p-aminobenzamidine. Normal factor IX showed complete activation in one hour as determined by measuring the increase in fluorescence when p-aminobenzamidine bound to activated factor IX. Factor IX Hilo showed no increase in fluorescence even after 24 hours, indicating that the active site was not exposed. Polyacrylamide gel electrophoresis showed that factor IX Hilo was cleaved to a light chain plus a larger peptide with a molecular weight equivalent to a heavy chain covalently linked to an activation peptide. Amino terminal amino acid sequencing of factor IX Hilo cleaved by factor Xla showed cleavage only at Arg145-Ala146, indicating that the Gln180-Val181 bond was not cleaved and that the active site was thus not exposed. The presence of factor IX Hilo in patient plasma was responsible for the patient having a very long ox brain prothrombin time characteristic of severe hemophilia Bm. Patient plasma had an ox brain prothrombin time of 100 seconds using a Thrombotest kit, significantly prolonged over the normal control value of 45 seconds. When factor IX Hilo was depleted from patient plasma using an immunoaffinity column, the ox brain prothrombin time decreased to 41 seconds. When factor IX Hilo was added back to depleted patient plasma, to normal plasma depleted of factor IX by the same affinity column, or to plasma from a CRM- hemophilia B patient, the ox brain prothrombin time was significantly prolonged. We conclude that the Arg180 to Gln mutation in factor IX Hilo results in a molecule that cannot be activated by factor Xla. Further, our data suggest that the mutation results in a molecule that interacts with components of the extrinsic pathway to give

  16. Construção de indicadores de eficiência hídrica urbana: desafio para a gestão ambiental urbana

    Directory of Open Access Journals (Sweden)

    Liza Maria Souza de Andrade

    2007-12-01

    sanitário, limpeza urbana, gestão de resíduos sólidos, uso do solo e legislação ambiental – que possam tangenciar os diferentes tipos de zoneamento de forma sistêmica por meio de um estudo dos princípios da gestão ecológica do ciclo da água e dos critérios ambientais adotados para a implantação de futuros Planos Diretores de Drenagem urbana – PDDUs para a construção de indicadores de sustentabilidade intra-urbana de eficiência hídrica. (esse período está bastante extenso e um pouco confuso. Vou pensar em algo para ele.

  17. Molecular and electronic structure of thin films of protoporphyrin(IX)Fe(III)Cl

    Science.gov (United States)

    Snyder, Shelly R.; White, Henry S.

    1991-11-01

    Electrochemical, scanning tunneling microscopy (STM), and tunneling spectroscopy studies of the molecular and electronic properties of thin films of protoporphyrin(IX)Fe(III)Cl (abbreviated as PP(IX)Fe(III)Cl) on highly oriented pyrolytic graphite (HOPG) electrodes are reported. PP(IX)Fe(III)Cl films are prepared by two different methods: (1) adsorption, yielding an electrochemically-active film, and (2) irreversible electrooxidative polymerization, yielding an electrochemically-inactive film. STM images, in conjunction with electro-chemical results, indicate that adsorption of PP(IX)Fe(III)Cl from aqueous solutions onto freshly cleaved HOPG results in a film comprised of molecular aggregates. In contrast, films prepared by irreversible electrooxidative polymerization of PP(IX)Fe(III)Cl have a denser, highly structured morphology, including what appear to be small pinholes (approx. 50A diameter) in an otherwise continuous film.

  18. Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells.

    Science.gov (United States)

    Federici, Cristina; Lugini, Luana; Marino, Maria Lucia; Carta, Fabrizio; Iessi, Elisabetta; Azzarito, Tommaso; Supuran, Claudiu T; Fais, Stefano

    2016-01-01

    Proton Pump Inhibitors (PPIs) reduce tumor acidity and therefore resistance of tumors to drugs. Carbonic Anhydrase IX (CA IX) inhibitors have proven to be effective against tumors, while tumor acidity might impair their full effectiveness. To analyze the effect of PPI/CA IX inhibitors combined treatment against human melanoma cells. The combination of Lansoprazole (LAN) and CA IX inhibitors (FC9-399A and S4) has been investigated in terms of cell proliferation inhibition and cell death in human melanoma cells. The combination of these inhibitors was more effective than the single treatments in both inhibiting cell proliferation and in inducing cell death in human melanoma cells. These results represent the first successful attempt in combining two different proton exchanger inhibitors. This is the first evidence on the effectiveness of a new approach against tumors based on the combination of PPI and CA IX inhibitors, thus providing an alternative strategy against tumors.

  19. The importance of protoporphyrin IX efflux for ALA-PDT dosimetry

    International Nuclear Information System (INIS)

    Milanetto, M C; Imasato, H; Perussi, J R

    2009-01-01

    One of the major advances in PDT is the use of 5-aminolevulinic acid (ALA) to induce the production of an endogenous photosensitizer inside the cells using intracellular enzymatic pathways. ALA is the first intermediate in heme biosynthesis and a precursor of the protoporphyrin IX (PpIX). When activated by light, this efficient photosensitizer accumulated in the target cells can produce cytotoxicity. The aim of this study was to find the best conditions for cell killing using ALA to temporarily increase the concentration of PpIX in two cell lines. It was shown that a considerable efflux of synthesized PpIX occurs. Since this efflux is time-dependent, it is essential to know the optimum time for irradiation after ALA administration. So, the efflux of PpIX from the cells is an important parameter to be considered for ALA-PDT dosimetry

  20. 19.-25. IX toimub Rüütelkonna hoones Kumu pärlite nädal...

    Index Scriptorium Estoniae

    2005-01-01

    23. IX kõneleb Anu Allikvee teemal "Eestlane baltisaksa kunstnike vaatepiiris"; 24. IX tutvustab Mai Levin Eugen Dückeri maale, 25. IX Ene Lamp Konrad Mäge. Vt. ka lk. 24 Tähtede nädal 26. IX-2. X - kohtumisõhtutel esinevad Marika ja Heinz Valk, Jüri Kuuskemaa, Sirje Helme, Pekka Vapaavuori, Inge Teder, Rain Lõhmus

  1. Inactivation of Dengue and Yellow Fever viruses by heme, cobalt-protoporphyrin IX and tin-protoporphyrin IX.

    Science.gov (United States)

    Assunção-Miranda, I; Cruz-Oliveira, C; Neris, R L S; Figueiredo, C M; Pereira, L P S; Rodrigues, D; Araujo, D F F; Da Poian, A T; Bozza, M T

    2016-03-01

    To investigate the effect of heme, cobalt-protoporphyrin IX and tin-protoporphyrin IX (CoPPIX and SnPPIX), macrocyclic structures composed by a tetrapyrrole ring with a central metallic ion, on Dengue Virus (DENV) and Yellow Fever Virus (YFV) infection. Treatment of HepG2 cells with heme, CoPPIX and SnPPIX after DENV infection reduced infectious particles without affecting viral RNA contents in infected cells. The reduction of viral load occurs only with the direct contact of DENV with porphyrins, suggesting a direct effect on viral particles. Previously incubation of DENV and YFV with heme, CoPPIX and SnPPIX resulted in viral particles inactivation in a dose-dependent manner. Biliverdin, a noncyclical porphyrin, was unable to inactivate the viruses tested. Infection of HepG2 cells with porphyrin-pretreated DENV2 results in a reduced or abolished viral protein synthesis, RNA replication and cell death. Treatment of HepG2 or THP-1 cell lineage with heme or CoPPIX after DENV infection with a very low MOI resulted in a decreased DENV replication and protection from death. Heme, CoPPIX and SnPPIX possess a marked ability to inactivate DENV and YFV, impairing its ability to infect and induce cytopathic effects on target cells. These results open the possibility of therapeutic application of porphyrins or their use as models to design new antiviral drugs against DENV and YFV. © 2016 The Society for Applied Microbiology.

  2. Transformación de la Estructura Urbana de la Ciudad de Toluca, Siglo XIX

    Directory of Open Access Journals (Sweden)

    Georgina Alicia García Luna Villagrán

    2014-12-01

    Full Text Available La configuración urbana de las ciudades actuales, ha sido el resultado de distintos procesos históricos influyendo en la organización del territorio, elementos como las actividades económicas y la aplicación de reformas urbanas, así como los equipamientos, servicios y los recursos humanos y físicos han sido elementos que han intervenido en las áreas urbanas, al respecto el propósito del presente trabajo consiste en describir la transformación de la estructura urbana de la ciudad de Toluca a partir de la desamortización de bienes eclesiásticos, para identificar sus principales efectos en su traza urbana, en sus espacios públicos y en el crecimiento urbano de la ciudad. Por lo anterior se logró demostrar que la desamortización ocasionó algunos cambios en la forma de la ciudad actual después de haberse vendido las propiedades del clero ya que hubo otros hechos que también impactaron en la configuración urbana de Toluca.

  3. In vitro characterization of high purity factor IX concentrates for the treatment of hemophilia B.

    Science.gov (United States)

    Limentani, S A; Gowell, K P; Deitcher, S R

    1995-04-01

    This study employed sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis and immunoblotting to assess the purity of seven high purity factor IX concentrates: Aimafix (Aima), AlphaNine-SD (Alpha Therapeutic), Factor IX VHP (Biotransfusion), Immunine (Immuno), Mononine (Armour Pharmaceutical), Nanotiv (Kabi Pharmacia), and 9MC (Blood Products Laboratory). The mean specific activity of these products ranged from 68 U factor IX/mg (Aimafix) to 246 U factor IX/mg (Mononine). SDS-PAGE analysis showed that the highest purity product, Mononine, had a single contaminating band under non-reducing conditions. Two additional bands were detected when this product was analyzed under reducing conditions. All other products had multiple contaminating bands that were more apparent under reducing than non-reducing conditions. The immunoblot for factor IX showed a dominant factor IX band for all products. In addition, visible light chain of factor IX was detected for AlphaNine-SD, Factor IX VHP, Immunine, Mononine, Nanotiv, and 9MC, suggesting that the factor IX in these products had undergone partial activation to factor IXa. Another contaminating band was visible at 49,500 for all of the products except 9MC. In addition to this band, high molecular weight contaminants were apparent for some products, most notably AlphaNine-SD. The identity of these bands is unknown. Immunoblotting failed to demonstrate factor VII as a contaminant of any of the high purity products, although factor VIIa could be detected in some lots of Immunine, Nanotiv, and 9MC by a clot-based assay. Factor X contaminated Aimafix, AlphaNine-SD, Factor IX VHP, Immunine, Nanotiv, and 9MC, but activation products of factor X were not detected.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. Increase in protoporphyrin IX after 5-aminolevulinic acid based photodynamic therapy is due to local re-synthesis

    NARCIS (Netherlands)

    de Bruijn, Henriëtte S.; Kruijt, Bastiaan; van der Ploeg-van den Heuvel, Angélique; Sterenborg, Henricus J. C. M.; Robinson, Dominic J.

    2007-01-01

    Protoporphyrin IX (PpIX) fluorescence that is bleached during aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) increases again in time after treatment. In the present study we investigated if this increase in PpIX fluorescence after illumination is the result of local re-synthesis or of

  5. Induction of protoporphyrin IX by aminolaevulinic acid in actinic keratosis, psoriasis and normal skin: preferential porphyrin enrichment in differentiated cells.

    NARCIS (Netherlands)

    Smits, T.; Laarhoven, A.I.M. van; Staassen, A.; Kerkhof, P.C.M. van de; Erp, P.E.J. van; Gerritsen, M.J.P.

    2009-01-01

    BACKGROUND: In photodynamic therapy the endogenous photosensitizer protoporphyrin IX (PpIX) is synthesized following topical application of aminolaevulinic acid (ALA). However, different tissues have distinct PpIX-accumulating properties, due to differences in penetration of ALA through the stratum

  6. Validation of the protoporphyrin IX-triplet state lifetime technique for mitochondrial oxygen measurements in the skin

    NARCIS (Netherlands)

    F.A. Harms (Floor A.); S.I.A. Bodmer (Sander I. A.); N.J.H. Raat (Nicolaas); R.J. Stolker (Robert); E.G. Mik (Egbert)

    2012-01-01

    textabstractMitochondrial oxygen tension can be measured in vivo by means of oxygen-dependent quenching of delayed fluorescence of protoporphyrin IX (PpIX). Here we demonstrate that mitochondrial PO2 (mitoPO2) can be measured in the skin of a rat after topical application of the PpIX precursor

  7. Contribution to the study of neutron-neutron interactions using the three-nucleon experiment D(n,nnp) at 14.5 MeV: evaluation of parasitic events; Contribution a l'etude de l'interaction neutron-neutron a l'aide de l'experience a trois nucleons D(n,nnp) A 14.5 MeV: evaluation des evenements parasites

    Energy Technology Data Exchange (ETDEWEB)

    Ducharme, C [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1969-07-01

    This work is related to the interpretation of the results concerning the three nucleon experiment, D(n,nnp), at 14.5 MeV, carried out by double time-of-flight spectrometry. The present work consists in the simulation of the main parasitic events using the Monte-Carlo method for extracting them from the experimental distribution around the n-n pole. (author) [French] Cette etude rentre dans le cadre de l'interpretation des resultats de l'experience a trois nucleons D(n,nnp) a 14.5 MeV effectuee par spectrometrie a double temps-de-vol. Le present travail consiste a simuler les evenements parasites principaux par une methode de Monte-Carlo pour les soustraire de la distribution experimentale autour du pole n-n. (auteur)

  8. THE IX EUROPEAN FORUM ON ANTIPHOSPHOLIPID ANTIBODIES. A BRIEF REVIEW

    Directory of Open Access Journals (Sweden)

    Nataliya V Seredavkina

    2014-01-01

    Full Text Available The article presents a brief review of the proceedings of the IX European Forum on antiphospholipid antibodies held in May 2013 in Krakow (Poland. The aim of the Forum is to coordinate multicenter projects focused on antiphospholipid antibodies (aPL, both clinical and fundamental research, based on cooperation between the European countries. The main purpose is to stimulate research into all aspects of aPL, to facilitate the exchange of information between institutions, and to involve many centers in different countries into scientific research on this issue. The issues of standardization of the diagnostic criteria for antiphospholipid syndrome (APS, primarily serological markers (their specificity, sensitivity and correlation with clinical manifestations, as well as non-criterial manifestations of APS, were considered at the meeting. In addition, the therapy problems were discussed.

  9. The order of chaos on a Bianch IX cosmological model

    Energy Technology Data Exchange (ETDEWEB)

    Bugalho, H; da Silva, A R; Ramos, J S

    1986-12-01

    The purpose of this paper is to analyze the chaotic behavior that can arise on a type-IX cosmological model using methods from dynamic systems theory and symbolic dynamics. Specifically, instead of the Belinski-Khalatnikov-Lifschitz model, we use the iterates of a monotonously increasing map of the circle with a discontinuity, and for the Hamiltonian dynamics of Misner's Mixmaster model we introduce the iterates of a noninvertible map. An equivalence between these two models can easily be brought upon by translating them in symbolic dynamical terms. The resulting symbolic orbits can be inserted in an ordered tree structure set, and so we can present an effective counting and referentation of all period orbits.

  10. DA TRAGÉDIA URBANA À FARSA DO URBANISMO REFORMISTA: a fetichização dos planos diretores participativos

    OpenAIRE

    CARLOS FREDERICO LAGO BURNETT

    2007-01-01

    Nos anos 80, como reação às desigualdades sócio-espaciais das cidades brasileiras, o projeto da Reforma Urbana logrou unificar, em torno de um movimento por política urbana igualitária e distributiva, intelectuais da Academia e entidades da organização popular. Parcialmente reconhecido pela Constituição Federal de 1988, o ideário da Reforma Urbana ficou subordinado ao planejamento urbano, pois o Plano Diretor foi declarado instrumento maior da política urbana municipal. Inic...

  11. Syntheses of carbon-13 labeled protoporphyrin-IX for spectroscopic studies of heme proteins

    International Nuclear Information System (INIS)

    Fujinari, E.M.

    1985-01-01

    The development of various methodologies for synthesis of selectively tailored protoporphyrin-IX dimethyl ester are presented. The iron(II) complex of protoporphyrin-IX is the heme, the prosthetic group for Hb, Mb, cytochromes and peroxidases. The significance of this research is to provide direct means to establish definitive carbon-13 NMR assignments of heme proteins in order to study not only the structure-function relationships, but also protein dynamics of these vital systems. Carbon-13 labeling at the beta-vinyl position was first achieved by ozonolysis of protoporphyrin-IX dimethyl ester. Column LC method were used to first isolate 2,4-diformyldeuteroporphyrin-IX dimethyl ester. Concomitantly, monofomyl-monovinyl porphyrins were obtained as a mixture of two isomers. This mixture was separated by MPLC or prep HPLC to afford the isomerically pure products, Spirographis porphyrin dimethyl ester and Iso-Spirographis porphyrin dimethyl ester. A Wittig reaction to each of these porphyrins with 13 C-methyltriphenylphosphonium iodide gave 2,4-bis[ 13 C 2 ]-vinyl protoporphyrin-IX dimethyl ester, 2-[ 13 C 2 ]-vinyl protoporphyrin-IX dimethyl ester, and the 4-[ 13 C 2 ]-vinyl protoporphyrin-IX dimethyl ester, respectively

  12. Evaluation of Sonochemiluminescence in a Phantom in the Presence of Protoporphyrin IX Conjugated to Nanoparticles

    International Nuclear Information System (INIS)

    Shanei, A.; Sazgarnia, A.; Hassanzadeh-Kayyat, M.; Eshghi, H.; Soudmand, S.; Attaran Kakhki, N.

    2012-01-01

    When a liquid is irradiated with high-intensity and low-frequency ultrasound, acoustic cavitation occurs and there are some methods to determine and quantify this phenomenon. The existing methods for performing these experiments include sonochemiluminescence and chemical dosimetric methods. The particles in a liquid decrease the ultrasonic intensity threshold needed for cavitation onset. In this study, a new nano conjugate made up of Protoporphyrin IX and gold nanoparticles, i.e., Au-PpIX was used to provide nucleation sites for cavitation. The nonradiative relaxation time of PpIX in the presence of GNPs is longer than the similar time for PpIX without GNPs. This effect can be used in medical diagnostic and therapeutic applications. The acoustic cavitation activity was investigated studying integrated sonochemiluminescence signal in the wavelength range of 400-500 nm in polyacrylamide gel phantom containing luminol using a cooled CCD spectrometer at different intensities of 1 MHz ultrasound. In order to confirm these results, a chemical dosimetric method was utilized, too. sonochemiluminescence signal level in gel phantom containing Au-PpIX was higher than the other phantoms. These results have been confirmed by the chemical dosimetric data. This finding can be related to the existence of PpIX as a sensitizer and GNPs as cavitation nuclei. In other words, nanoparticles have acted as the sites for cavitation and have increased the cavitation rate. Another theory is that activation of PpIX has produced more free radicals and has enhanced the sonochemiluminescence signal level.

  13. The H IX galaxy survey - II. H I kinematics of H I eXtreme galaxies

    Science.gov (United States)

    Lutz, K. A.; Kilborn, V. A.; Koribalski, B. S.; Catinella, B.; Józsa, G. I. G.; Wong, O. I.; Stevens, A. R. H.; Obreschkow, D.; Dénes, H.

    2018-05-01

    By analysing a sample of galaxies selected from the H I Parkes All Sky Survey (HIPASS) to contain more than 2.5 times their expected H I content based on their optical properties, we investigate what drives these H I eXtreme (H IX) galaxies to be so H I-rich. We model the H I kinematics with the Tilted Ring Fitting Code TiRiFiC and compare the observed H IX galaxies to a control sample of galaxies from HIPASS as well as simulated galaxies built with the semi-analytic model DARK SAGE. We find that (1) H I discs in H IX galaxies are more likely to be warped and more likely to host H I arms and tails than in the control galaxies, (2) the average H I and average stellar column density of H IX galaxies is comparable to the control sample, (3) H IX galaxies have higher H I and baryonic specific angular momenta than control galaxies, (4) most H IX galaxies live in higher spin haloes than most control galaxies. These results suggest that H IX galaxies are H I-rich because they can support more H I against gravitational instability due to their high specific angular momentum. The majority of the H IX galaxies inherits their high specific angular momentum from their halo. The H I content of H IX galaxies might be further increased by gas-rich minor mergers. This paper is based on data obtained with the Australia Telescope Compact Array through the large program C 2705.

  14. DNA Damage and Cell Cycle Arrest Induced by Protoporphyrin IX in Sarcoma 180 Cells

    Directory of Open Access Journals (Sweden)

    Qing Li

    2013-09-01

    Full Text Available Background: Porphyrin derivatives have been widely used in photodynamic therapy as effective sensitizers. Protoporphyrin IX (PpIX, a well-known hematoporphyrin derivative component, shows great potential to enhance light induced tumor cell damage. However, PpIX alone could also exert anti-tumor effects. The mechanisms underlying those direct effects are incompletely understood. This study thus investigated the putative mechanisms underlying the anti-tumor effects of PpIX on sarcoma 180 (S180 cells. Methods: S180 cells were treated with different concentrations of PpIX. Following the treatment, cell viability was evaluated by the 3-(4, 5- dimethylthiazol-2-yl-2, 5-diphenyltetrazoliumbromide (MTT assay; Disruption of mitochondrial membrane potential was measured by flow cytometry; The trans-location of apoptosis inducer factor (AIF from mitochondria to nucleus was visualized by confocal laser scanning microscopy; DNA damage was detected by single cell gel electrophoresis; Cell cycle distribution was analyzed by DNA content with flow cytometry; Cell cycle associated proteins were detected by western blotting. Results: PpIX (≥ 1 µg/ml significantly inhibited proliferation and reduced viability of S180 cells in a dose-dependent manner. PpIX rapidly and significantly triggered mitochondrial membrane depolarization, AIF (apoptosis inducer factor translocation from mitochondria to nucleus and DNA damage, effects partially relieved by the specific inhibitor of MPTP (mitochondrial permeability transition pore. Furthermore, S phase arrest and upregulation of the related proteins of P53 and P21 were observed following 12 and 24 h PpIX exposure. Conclusion: PpIX could inhibit tumor cell proliferation by induction of DNA damage and cell cycle arrest in the S phase.

  15. Kinetics of the Factor XIa catalyzed activation of human blood coagulation Factor IX

    International Nuclear Information System (INIS)

    Walsh, P.N.; Bradford, H.; Sinha, D.; Piperno, J.R.; Tuszynski, G.P.

    1984-01-01

    The kinetics of activation of human Factor IX by human Factor XIa was studied by measuring the release of a trichloroacetic acid-soluble tritium-labeled activation peptide from Factor IX. Initial rates of trichloroacetic acid-soluble 3 H-release were linear over 10-30 min of incubation of Factor IX (88 nM) with CaCl 2 (5 mM) and with pure (greater than 98%) Factor XIa (0.06-1.3 nM), which was prepared by incubating human Factor XI with bovine Factor XIIa. Release of 3 H preceded the appearance of Factor IXa activity, and the percentage of 3 H released remained constant when the mole fraction of 3 H-labeled and unlabeled Factor IX was varied and the total Factor IX concentration remained constant. A linear correlation (r greater than 0.98, P less than 0.001) was observed between initial rates of 3 H-release and the concentration of Factor XIa, measured by chromogenic assay and by radioimmunoassay and added at a Factor IX:Factor XIa molar ratio of 70-5,600. Kinetic parameters, determined by Lineweaver-Burk analysis, include K/sub m/ (0.49 microM) of about five- to sixfold higher than the plasma Factor IX concentration, which could therefore regulate the reaction. The catalytic constant (k/sub cat/) (7.7/s) is approximately 20-50 times higher than that reported by Zur and Nemerson for Factor IX activation by Factor VIIa plus tissue factor. Therefore, depending on the relative amounts of Factor XIa and Factor VIIa generated in vivo and other factors which may influence reaction rates, these kinetic parameters provide part of the information required for assessing the relative contributions of the intrinsic and extrinsic pathways to Factor IX activation, and suggest that the Factor XIa catalyzed reaction is physiologically significant

  16. Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B

    Directory of Open Access Journals (Sweden)

    Sushrusha eNayak

    2011-12-01

    Full Text Available Intramuscular (IM administration of an adeno-associated viral (AAV vector represents a simple and safe method of gene transfer for treatment of the X-linked bleeding disorder hemophilia B (factor IX, F.IX, deficiency. However, the approach is hampered by an increased risk of immune responses against F.IX. Previously, we demonstrated that the drug cocktail of immune suppressants rapamycin, IL-10, and a specific peptide (encoding a dominant CD4+ T cell epitope caused an induction of regulatory T cells (Treg with a concomitant apoptosis of antigen-specific effector T cells (J. Thromb. Haemost. 7:1523, 2009. This protocol was effective in preventing inhibitory antibody formation against human F.IX (hF.IX in muscle gene transfer to C3H/HeJ hemophilia B mice (with targeted F9 gene deletion. Here, we show that this protocol can also be used to reverse inhibitor formation. IM injection of AAV1-hF.IX vector resulted in inhibitors of on average 8-10 BU within 1 month. Subsequent treatment with the tolerogenic cocktail accomplished a rapid reduction of hF.IX-specific antibodies to <2 BU, which lasted for >4.5 months. Systemic hF.IX expression increased from undetectable to >200 ng/ml, and coagulation times improved. In addition, we developed an alternative prophylactic protocol against inhibitor formation that did not require knowledge of T cell epitopes, consisting of daily oral administration of rapamycin for 1-month combined with frequent, low-dose intravenous injection of hF.IX protein. Experiments in T cell receptor transgenic mice showed that the route and dosing schedule of drug administration substantially affected Treg induction. When combined with intravenous antigen administration, oral delivery of rapamycin had to be performed daily in order to induce Treg, which were suppressive and phenotypically comparable to natural Treg.

  17. Modulation of the endogenous production of protoporphyrin IX in a yeast-based model organism

    Science.gov (United States)

    Joniová, Jaroslava; Gerelli, Emmanuel; Wagnières, Georges

    2017-02-01

    The main aim of this study was to assess conditions at which simple yeast-based model organism produces maximal levels of protoporphyrin IX (PpIX) after an exogenous administration of its precursor, 5-aminolevulinic acid (ALA), and the ferrous-ion chelator 2,2'-bipyridyl. We observed that the fluorescing porphyrin, produced after these administrations, was likely to be PpIX since fluorescence spectroscopy of the porphyrins produced endogenously in yeast cells resembles that of PpIX in DMSO and in vivo in the chick's chorioallantoic membrane model. Also, fluorescence lifetimes of these porphyrins are very similar to that of PpIX in vitro and in vivo. This suggests that PpIX is the main fluorescent compound produced by yeast in our conditions. We found that the conditions at which yeast produces the maximal PpIX were a synchronous administration of 5 μM ALA and 1 mM 2,2'-bipyridyl for yeast incubated in aqueous glucose and 1 mM 2,2'-bipyridyl in the presence of YPD medium. Such a simple model is of high interest to study basic mechanisms involved in the mitochondrial respiration since PpIX, which is produced in this organelle, can be used as an oxygen sensor, or to perform photodynamic therapy and photodiagnosis. Since the absorption and scattering coefficients of this model are much smaller than those of soft tissues over the visible part of the spectrum, a version of this model loaded with appropriated amounts of light absorbing and scattering particles could be designed as a phantom to mimic tumors containing PpIX, a useful tool to optimize certain cancer photodetection set-ups.

  18. Increased protoporphyrin IX accumulation does not improve the effect of photodynamic therapy for actinic keratosis

    DEFF Research Database (Denmark)

    Nissen, C V; Heerfordt, I M; Wiegell, S R

    2017-01-01

    BACKGROUND: Photodynamic therapy (PDT) with methyl aminolaevulinate (MAL) is highly effective for treating actinic keratosis (AK) on the face/scalp, but less effective on the extremities. Insufficient accumulation of protoporphyrin IX (PpIX) may cause these inferior efficacy rates. However...... (P = 0·001 and P = 0·002, respectively). However, the median total clearance rates did not improve accordingly: 3hC+ (55·0%), 21hC- (55·0%) and 21hC+ (53·6%). Conversely, insufficient PpIX accumulation in the 3hC- regimen led to a significantly lower clearance rate (33·3%) than the other regimens (P...

  19. Evaluation of the potential inhibitor of Ix (Pp-Ix) protoporphyrin of the genetic damage induced by gamma rays administered to different dose reasons in Drosophila melanogaster

    International Nuclear Information System (INIS)

    Flores A, J. A.

    2016-01-01

    Ionizing radiation can damage in DNA directly or indirectly by free radicals (Rl), characterized by unstable and highly reactive. To avoid damage by Rl the cell has endogenous antioxidants such as Sod, Cat, GSH or exogenous as some vitamins, but if with these mechanisms does not reach the cell homeostasis, the consequence may be the generation of chronic-disease degenerative such as cancer. This study was conducted in order to test the inhibitory role of Rl protoporphyrin Ix (Pp-Ix), induced by 20 Gy of gamma rays administered at different dose ratios using the assay of somatic mutation and recombination in the Drosophila wing. The results indicated that 20 Gy delivered at a rate of low dose (6.659 Gy/h), caused elevated frequencies of genetic damage (p <0.001), compared with those that induced a high dose reason (1111.42 Gy/h) in larvae of 48 h old. The difference is probably due to an indirect damage by Rl; when this hypothesis was approved with the possible inhibitor role of Pp-Ix (0.69 m M), damage was increased with the two reasons of tested doses. This result may be due to: 1) the Pp-Ix is not a good inhibitor of Rl, 2) the difference in the frequency of mutation found with both dose reasons, not due to Rl so that this compound did not reduce the genetic damage, and 3) that Pp-Ix acts as pro oxidant. (Author)

  20. Megaciudades, globalización y viabilidad urbana

    Directory of Open Access Journals (Sweden)

    Boris Graizbord

    2012-02-01

    Full Text Available Para fin del siglo XX había varios cientos de ciudades millonarias siendo que en 1990 se contaban menos de una docena. La inercia de crecimiento y concentración demográfica en grandes urbes parece que continuará, al menos durante el presente siglo, pues el crecimiento demográfico esperado entre 2000 y 2025, de cerca de cuatro mil millones de habitantes en el mundo, al menos tres cuartas partes o más ocurrirá, como ha sido hasta ahora y desde los años setenta, en Asia, África y América Latina. En este trabajo se presenta una descripción de la forma en que se distribuyen las grandes ciudades en el mundo; se hace referencia breve a las metrópolis mexicanas; y se intenta explicar el crecimiento de las grandes ciudades y los factores que explican su tamaño. El texto termina con una reflexión acerca de las implicaciones que estas grandes ciudades tienen para la política urbana y ambiental.

  1. De perto e de dentro: notas para uma etnografia urbana

    Directory of Open Access Journals (Sweden)

    Magnani José Guilherme Cantor

    2002-01-01

    Full Text Available O texto busca pôr em relação duas linhas de análise, uma sobre cidade e outra sobre etnografia. O objetivo é discutir as possibilidades que este enfoque, próprio da antropologia, abre para o estudo da dinâmica urbana. Tomando como ponto de partida a apresentação de alguns quadros analíticos sobre o fenômeno urbano contemporâneo, caracterizados como um "olhar de fora e de longe", é desenvolvida a perspectiva da etnografia, chamada, por contraste, de um "olhar de perto e de dentro". Explicitados os pressupostos teóricos que sustentam essa posição, é apresentada uma estratégia de pesquisa com base nessa argumentação para, finalmente, mostrar seu uso em alguns exemplos etnográficos mais recentes. O argumento termina sinalizando que um olhar "distanciado" amplia e complementa a perspectiva proposta, possibilitando a articulação do recorte etnográfico, bem delimitado, com planos e modelos mais gerais de análise.

  2. La funcionalidad de los medios rurales en las sociedades urbanas

    Directory of Open Access Journals (Sweden)

    Enrique Moltó Mantero

    2004-01-01

    Full Text Available Los medios rurales en los países desarrollados han experimentado notables cambios en las funciones que desempeñan desde mediados de la década de los cincuenta del siglo veinte. Frente a unos ámbitos donde dominaban las actividades y modos de vida rurales, en las últimas décadas se observa la progresiva aparición de nuevos usos y actividades vinculados a su terciarización. La homogeneización de las pautas de comportamiento y de los modos de vida hace difícil disociar la sociedad urbana de la rural. Este artículo reflexiona sobre los diferentes procesos (éxodo rural, políticas de desarrollo rural, medios de comunicación, etc. que han intervenido en estas transformaciones y han favorecido los procesos de homogeneización de los medios rurales, sin embargo, es necesario insistir que uno de los rasgos de numerosos medios rurales es su diversidad. Esta heterogeneidad condiciona, no solo su evolución, sino también su grado de adaptación a las nuevas funciones que se les asignan. Este artículo pretende realizar una reflexión acerca de las posibles disfuncionalidades que la aplicación de políticas homogéneas está generando en ámbitos contrastados.

  3. Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate

    DEFF Research Database (Denmark)

    Wiegell, S.R.; Skiveren, J.; Philipsen, P.A.

    2008-01-01

    and protoporphyrin IX (PpIX) fluorescence, lesion type, lesion preparation and lesion localization. Methods Twenty-six patients with actinic keratoses (AKs) in different localizations and 34 patients with facial acne vulgaris were treated with methyl aminolaevulinate-PDT. Patients with acne were illuminated using......) patients with acne had a pain score of 6 [interquartile range (IQR) 5-7] compared with 8 (IQR 6-10) when using a fluence rate of 68 mW cm(-2) (P = 0.018). After correcting the pain score for PpIX fluorescence no differences in pain scores were found between first and second acne treatment, locations of AK...... lesions or between the two types of lesions. Conclusions Pain during PDT was correlated with the PpIX fluorescence in the treatment area prior to illumination. Pain was reduced using a lower fluence rate during PDT of acne Udgivelsesdato: 2008/4...

  4. Analysis of cell line variation in biochemical production of protoporphyrin IX

    Science.gov (United States)

    Gibbs, Summer L.; Chen, Bin; O'Hara, Julia A.; Hoopes, P. Jack; Hasan, Tayyaba; Pogue, Brian W.

    2006-02-01

    Protoporphyrin IX (PpIX) is produced via the heme synthesis pathway by the cell following administration of aminolevulinic acid (ALA). ALA synthase, the enzyme that produces ALA in the cell from glycine and succinyl-coenzyme A, is inhibited in a feedback mechanism by heme and thus is the rate limiting enzyme in the heme synthesis pathway. Since ALA is administered systemically, the rate limiting step that naturally exists in the cells is bypassed, however it is currently unclear why cells have different rate limiting steps in the ALA-PpIX synthesis pathway, and more specifically which types of cancer cells are most productive. It has been determined that when the same amount of ALA is administered to a wide panel of cancer cells in vitro that vastly differing amounts of PpIX are produced. The steps for the ALA-PpIX pathway occur in and around the mitochondria of the cell, but interestingly no correlation is seen between PpIX production and mitochondrial content of the cell, following ALA administration. However, total cell area shows positive correlation with PpIX production. Administration of the iron chelator, 1,2-dimethyl-3-hydroxy-4-pyridone (L1) in combination with ALA allows the final step in the heme synthesis pathway, conversion of PpIX to heme, to be delayed and thus increases the detectable amount of PpIX in each cell line. The cell lines that have the lowest PpIX production following administration of ALA alone show the largest increase in production following the combined administration of ALA and L1. PpIX fluorescence is thought to be a measure of cellular activity and the goal of the current study was to determine which cell lines would be the most promising targets for fluorescence detection or monitoring response to therapy. The results indicate that the cells with larger size and larger numbers of mitochondria may be good potential targets for this therapy. While this conclusion may appear obvious, it is not universally true, and cellular specific

  5. Evaluation of Sonochemiluminescence in a Phantom in the Presence of Protoporphyrin IX Conjugated to Nanoparticles

    Directory of Open Access Journals (Sweden)

    Ahmad Shanei

    2012-03-01

    Full Text Available Introduction When a liquid is irradiated with high-intensity and low-frequency ultrasound, acoustic cavitation occurs and there are some methods to determine and quantify this phenomenon. The existing methods for performing these experiments include sonochemiluminescence (SCL and chemical dosimetric methods. The particles in a liquid decrease the ultrasonic intensity threshold needed for cavitation onset. In this study, a new nanoconjugate made up of Protoporphyrin IX (PpIX and gold nanoparticles (GNP, i.e., Au-PpIX was used to provide nucleation sites for cavitation. The nonradiative relaxation time of PpIX in the presence of GNPs is longer than the similar time for PpIX without GNPs. This effect can be used in medical diagnostic and therapeutic applications. Materials and Methods The acoustic cavitation activity was investigated studying integrated SCL signal in the wavelength range of 400-500 nm in polyacrylamide gel phantom containing luminol using a cooled CCD spectrometer at different intensities of 1 MHz ultrasound. In order to confirm these results, a chemical dosimetric method was utilized, too. Results SCL signal level in gel phantom containing Au-PpIX was higher than the other phantoms. These results have been confirmed by the chemical dosimetric data. Conclusion This finding can be related to the existence of PpIX as a sensitizer and GNPs as cavitation nuclei. In other words, nanoparticles have acted as the sites for cavitation and have increased the cavitation rate. Another theory is that activation of PpIX has produced more free radicals and has enhanced the SCL signal level.

  6. Violência Urbana e Sentimento de Insegurança

    OpenAIRE

    Lourenço, Nelson

    2012-01-01

    Violência e insegurança urbanas são questões societais centrais ocupando, em todo o Mundo, um espaço significativo no quadro da preocupação dos indivíduos e da vivência democrática. A sua análise pressupõe uma leitura ampla das dinâmicas urbanas e dos processos de metropolização que caracterizam a modernidade tardia nas suas dimensões social, cultural, política e económica. Não esgotando o universo das criminalidades da sociedade actual, a violência e insegurança urbanas impõem a necess...

  7. Le soluzioni di logistica urbana sono sostenibili? L'esempio di Cityporto

    Directory of Open Access Journals (Sweden)

    Jesus Gonzalez-Feliu

    2010-07-01

    Full Text Available La logistica urbana è un campo di riflessione volto ad approfondire le soluzioni ottimali per la distribuzione delle merci in ambito urbano e i relativi obiettivi ambientali. Ad oggi, molte azioni sono state intraprese dalle pubbliche autorità senza tenere conto, tuttavia, degli impatti che i nuovi schemi organizzativi possono avere sull’ attuale organizzazione delle imprese. Il contributo incentra la riflessione sul caso studio relativo alla città di Padova, in Italia: il sistema di logistica urbana CityPorto. In particolare, se ne analizzano le caratteristiche dal punto di vista della sostenibilità del sistema proposto, sia in riferimento alla dimensione imprenditoriale che a quella collettiva, mettendo in relazione le peculiarità della logistica urbana e le più estese catene distributive, di scala globale, di cui le prime sono parte integrante.

  8. Influence of protoporphyrin IX loaded phloroglucinol succinic acid dendrimer in photodynamic therapy

    Science.gov (United States)

    Kumar, M. Suresh; Aruna, P.; Ganesan, S.

    2018-03-01

    One of the major problems reported clinically for photosensitizers (PS) in Photodynamic therapy (PDT) is, the cause of side-effects to normal tissue due to dark toxicity. The usefulness of photosensitizers can be made possible by reducing its dark toxicity nature. In such scenario, biocompatible carriers can be used as a drug delivery system to evade the problems that arises while using free (dark toxic) drugs. So in this study, we have developed a nano drug delivery system called Phloroglucinol Succinic acid (PGSA) dendrimer, entrapped a photosensitizer, protoporphyrin IX (PpIX) inside the system and investigated whether the photodynamic efficacy of the anionic surface charged dendrimer-PpIX nano formulation is enhanced than achieved by the free PpIX in HeLa cancer cell lines. Moreover, the Reactive oxygen species (ROS) production was monitored using 2‧,7‧-dichlorodihydrofluorescein diacetate (H2DCF-DA)- ROS Marker with phase contrast microscopy for the IC50 values of free and dendrimer-PpIX nano formulation. Similarly, the mode of cell death has been confirmed by cell cycle analysis for the same. For the in vitro PDT application, we have used a simple light source (Light Emitting Diode) with a power of 30-50 mW for 20 min irradiation. Hence, in this study we have taken steps to report this anionic drug delivery system is good to consider for the photodynamic therapy applications with the photosensitizer, PpIX which satisfied the prime requirement of PDT.

  9. Effect of Photon Radiations in Semi-Rigid Artificial Tissue Sensitized by Protoporphyrin IX Encapsulated with Silica Nanoparticles

    Science.gov (United States)

    Makhadmeh, Ghaseb N.; Aziz, Azlan Abdul; Razak, Khairunisak Abdul; Al-Akhras, M.-Ali H.

    2018-02-01

    This study involves the synthesis of Protoporphyrin IX (PpIX) encapsulated with Silica Nanoparticles (SiNPs) as an application for Photodynamic therapy. Semi-rigid artificial tissues with optical features similar to human tissue were used as sample materials to ascertain the efficacy of PpIX encapsulated with SiNPs. The disparity in optical characteristics (transmittance, reflectance, scattering, and absorption) of tissues treated with encapsulated PpIX and naked PpIX under light exposure (Intensity at 408 nm ~1.19 mW/cm2) was explored. The optimal exposure times required for naked PpIX and SiNPs encapsulated PpIX to engulf Red Blood Cells (RBCs) in the artificial tissue were subsequently measured. Comparative analysis showed that the encapsulated PpIX has a 91.5 % higher efficacy than naked PpIX. The results prove the applicability of PpIX encapsulated with SiNP on artificial tissue and possible use on human tissue.

  10. Homoclinic chaos in axisymmetric Bianchi IX cosmologies reexamined

    International Nuclear Information System (INIS)

    Soares, I. Damiao; Stuchi, T.J.

    2005-01-01

    The dynamics of Bianchi IX models with two scale factors A(t) and B(t) is reexamined. The matter content of the model is assumed to be comoving dust plus a positive cosmological constant. We make a complete numerical construction of topological structures present in the phase space of the model, as the center manifold of periodic orbits and the stable and unstable cylinders of orbits that emerge from the center manifold, associated to a saddle-center critical point. We exhibit the homoclinic intersections of the unstable and stable cylinders that produce homoclinic chaos in the models. A=0 is not a singularity of the Hamiltonian dynamics and any truncation of the dynamics at A=0 is bound to a loss of information. We make an explicit construction of a set with a horseshoe structure in the A>0 region, of initial conditions corresponding to initially expanding universes. We show that the dynamics of this set is chaotic even if restricted to the region A>0 and has the Einstein universe configuration as a chaotic scatterer. The result however demands the information of the Hamiltonian dynamics in whole phase space, including the region A<0. This refutes recent claims that no homoclinic chaos is present in the dynamics of the model

  11. Oscillating Bianchi IX universe in Horava-Lifshitz gravity

    International Nuclear Information System (INIS)

    Misonoh, Yosuke; Maeda, Kei-ichi; Kobayashi, Tsutomu

    2011-01-01

    We study a vacuum Bianchi IX universe in the context of Horava-Lifshitz gravity. In particular, we focus on the classical dynamics of the universe and analyze how anisotropy changes the history of the universe. For small anisotropy, we find an oscillating universe as well as a bounce universe just as the case of the Friedmann-Lemaitre-Robertson-Walker spacetime. However, if the initial anisotropy is large, we find the universe which ends up with a big crunch after oscillations if a cosmological constant Λ is zero or negative. For Λ>0, we find a variety of histories of the universe, that is a de Sitter expanding universe after oscillations in addition to the oscillating solution and the previous big crunch solution. This fate of the universe shows sensitive dependence of initial conditions, which is one of the typical properties of a chaotic system. If the initial anisotropy is near the upper bound, we find the universe starting from a big bang and ending up with a big crunch for Λ≤0, and a de Sitter expanding universe starting from a big bang for Λ>0.

  12. DISPERSIÓN URBANA Y OFERTA HÍDRICA EN EL EJE CAFETERO COLOMBIANO

    Directory of Open Access Journals (Sweden)

    GONZÁLEZ JUAN LEONARDO

    2012-11-01

    Full Text Available Este artículo presenta una caracterización del estado de la oferta hídrica en el contexto de dispersión urbana, entendida como la propagación de una ciudad y de sus barrios hacia las zonas rurales periféricas, en el eje cafetero colombiano. Los autores consideran que el conocimiento sobre el uso del suelo en las áreas de dispersión urbana y en los entornos donde se localizan los ecosistemas que sustentan el abasto hídrico, así como la eficiencia técnico operacional de las empresas de servicios públicos que operan allí, son factores claves para entender de manera integral la oferta hídrica local y regional. El trabajo analiza el grado de urbanización y la magnitud espacial de la dispersión urbana en los municipios de Manizales, Pereira y Armenia. Luego, caracteriza el estado ecológico-social del uso del suelo en los ecosistemas andinos y subandinos que abastecen a los acueductos integrados a la dispersión urbana. Por último, plantea las condiciones técnicas y operacionales de los prestadores del servicio de acueducto involucrados en la dispersión urbana, resaltando sus fortalezas y debilidades. Cabe destacar que la oferta hídrica dada en la dispersión urbana del eje cafetero tiende a ser cada vez más frágil en la medida en que este fenómeno incrementa su área y su demanda.

  13. Estatuto da cidade e juridificação da reforma urbana no Brasil

    OpenAIRE

    Ana Paula Soares Carvalho

    2012-01-01

    O início da década passada foi marcado por um importante evento relacionado ao tratamento das questões urbanas no Brasil. Em dez de julho de 2001, foi promulgada a Lei Federal n 10.257, conhecida como Estatuto da Cidade, que regulamenta o capítulo da política urbana da Constituição de 1988. O Estatuto da Cidade provê suporte legal consistente para aquelas municipalidades comprometidas com o enfrentamento dos problemas sociais e urbanos que afetam diariamente as condições de vida dos habitante...

  14. REFORMA URBANA, PLANEJAMENTO E CONTRADIÇÕES: A EXPERIÊNCIA DE GOIÂNIA.

    OpenAIRE

    Valério, Andrea Helena

    2012-01-01

    Este trabalho analisa as origens e desdobramentos do Movimento Nacional pela Reforma Urbana relacionando-o ao processo de democratização do planejamento urbano no Brasil e sua influência no desenvolvimento da cidade de Goiânia, tendo em vista, que esse movimento surgiu durante a retomada da democracia no país e se constituiu como elemento fundamental para a inserção do Capitulo da Política Urbana na Constituição de 1988. Para encontrar pontos originários e recompor a trajetó...

  15. Dispersión urbana y oferta hídrica en el eje cafetero colombiano

    OpenAIRE

    GONZÁLEZ, JUAN LEONARDO; GALEANO MORENO, JULIÁN; CAÑÓN BARRIGA, JULIO

    2012-01-01

    Este artículo presenta una caracterización del estado de la oferta hídrica en el contexto de dispersión urbana, entendida como la propagación de una ciudad y de sus barrios hacia las zonas rurales periféricas, en el eje cafetero colombiano. Los autores consideran que el conocimiento sobre el uso del suelo en las áreas de dispersión urbana y en los entornos donde se localizan los ecosistemas que sustentan el abasto hídrico, así como la eficiencia técnico operacional de las empresas de servicio...

  16. Redes urbanas y sistema de ciudades de Alemania: Algunas precisiones cara al siglo XXI

    OpenAIRE

    Serrano Martínez, José María

    2000-01-01

    El camino recorrido por Alemania ha sido el inverso al de otros países; aquí las ciudades han sido la base que ha permitido construir el país. Ello se advierte al estudiar la jerarquía urbana nacional y también en la propia organización singular de las redes urbanas regionales. Cada «Länder» ha conseguido un subsistema urbano bastante autónomo. Ahora bien, su elevada densidad de población irregularmente distribuida, y los apreciables desajustes socio-económicos territoriales, s...

  17. Una geografía del crimen: patrones, tendencias y percepciones urbanas.

    OpenAIRE

    Isabel Avendaño Flores

    2011-01-01

    En diciembre del 2000, en la Escuela de Geografía se presentaron públicamente dos documentos que se inscriben dentro en la Geografía Humana. Ambos conforman una unidad, se complementan y permiten repensar la ciudad de San José y su área de influencia: “Análisis espacial de la criminalidad urbana en el Área Metropolitana. Costa Rica. 1990-2000”, y “Percepción de la criminalidad urbana en el casco central de la ciudad de San José. Costa Rica. 2000”. Si en Costa Rica existiera la planificación t...

  18. The lower cranial nerves: IX, X, XI, XII.

    Science.gov (United States)

    Sarrazin, J-L; Toulgoat, F; Benoudiba, F

    2013-10-01

    The lower cranial nerves innervate the pharynx and larynx by the glossopharyngeal (CN IX) and vagus (CN X) (mixed) nerves, and provide motor innervation of the muscles of the neck by the accessory nerve (CN XI) and the tongue by the hypoglossal nerve (CN XII). The symptomatology provoked by an anomaly is often discrete and rarely in the forefront. As with all cranial nerves, the context and clinical examinations, in case of suspicion of impairment of the lower cranial nerves, are determinant in guiding the imaging. In fact, the impairment may be located in the brain stem, in the peribulbar cisterns, in the foramens or even in the deep spaces of the face. The clinical localization of the probable seat of the lesion helps in choosing the adapted protocol in MRI and eventually completes it with a CT-scan. In the bulb, the intra-axial pathology is dominated by brain ischemia (in particular, with Wallenberg syndrome) and multiple sclerosis. Cisternal pathology is tumoral with two tumors, schwannoma and meningioma. The occurrence is much lower than in the cochleovestibular nerves as well as the leptomeningeal nerves (infectious, inflammatory or tumoral). Finally, foramen pathology is tumoral with, outside of the usual schwannomas and meningiomas, paragangliomas. For radiologists, fairly hesitant to explore these lower cranial pairs, it is necessary to be familiar with (or relearn) the anatomy, master the exploratory technique and be aware of the diagnostic possibilities. Copyright © 2013 Éditions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.

  19. Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts

    International Nuclear Information System (INIS)

    Ditte, Zuzana; Ditte, Peter; Labudova, Martina; Simko, Veronika; Iuliano, Filippo; Zatovicova, Miriam; Csaderova, Lucia; Pastorekova, Silvia; Pastorek, Jaromir

    2014-01-01

    Carbonic anhydrase IX (CA IX) is a transmembrane enzyme that is present in many types of solid tumors. Expression of CA IX is driven predominantly by the hypoxia-inducible factor (HIF) pathway and helps to maintain intracellular pH homeostasis under hypoxic conditions, resulting in acidification of the tumor microenvironment. Carnosine (β-alanyl-L-histidine) is an anti-tumorigenic agent that inhibits the proliferation of cancer cells. In this study, we investigated the role of CA IX in carnosine-mediated antitumor activity and whether the underlying mechanism involves transcriptional and translational modulation of HIF-1α and CA IX and/or altered CA IX function. The effect of carnosine was studied using two-dimensional cell monolayers of several cell lines with endogenous CA IX expression as well as Madin Darby canine kidney transfectants, three-dimensional HeLa spheroids, and an in vivo model of HeLa xenografts in nude mice. mRNA and protein expression and protein localization were analyzed by real-time PCR, western blot analysis, and immunofluorescence staining, respectively. Cell viability was measured by a flow cytometric assay. Expression of HIF-1α and CA IX in tumors was assessed by immunohistochemical staining. Real-time measurement of pH was performed using a sensor dish reader. Binding of CA IX to specific antibodies and metabolon partners was investigated by competitive ELISA and proximity ligation assays, respectively. Carnosine increased the expression levels of HIF-1α and HIF targets and increased the extracellular pH, suggesting an inhibitory effect on CA IX-mediated acidosis. Moreover, carnosine significantly inhibited the growth of three-dimensional spheroids and tumor xenografts compared with untreated controls. Competitive ELISA showed that carnosine disrupted binding between CA IX and antibodies specific for its catalytic domain. This finding was supported by reduced formation of the functional metabolon of CA IX and anion exchanger 2 in the

  20. Protoporphyrin IX formation after topical application of methyl aminolaevulinate and BF-200 aminolaevulinic acid declines with age

    DEFF Research Database (Denmark)

    Nissen, C V; Philipsen, P A; Wulf, H C

    2015-01-01

    BACKGROUND: Topical photodynamic therapy (PDT) is a popular treatment modality in dermatology. The effect of PDT in epidermal cells depends on formation of protoporphyrin IX (PpIX) from 5-aminolevulinic acid (ALA). A variety of physiological changes in epidermal function occur with increasing age...... assessed. Treatment efficacy in relation to age was evaluated in 100 basal cell carcinomas (BCCs) treated with MAL-PDT. RESULTS: Both photosensitizers induced significantly more PpIX formation in the younger group. Linear regression revealed a significant age-related decline in PpIX formation after...

  1. Los hitos y los retos del desarrollo sostenible en la planificación urbana

    OpenAIRE

    González González, María Jesús; Lázaro y Torres, María Luisa de

    2005-01-01

    566 p El objetivo del estudio es analizar las iniciativas relacionadas con el desarrollo sostenible en la planificación urbana, fundamentando sus actuaciones claras y exactas para un lugar y contexto. Estas acciones deben ser vinculantes, lo que unicamente esposible a través de la planificación

  2. La Investigación urbana en América Latina

    Directory of Open Access Journals (Sweden)

    Martha Schteingart

    2000-01-01

    Full Text Available En este trabajo se hace un balance de los caminos recorridos en el campo de la investigación urbana en la mayor parte de los países de América Latina, con el fin de establecer algunos criterios básicos para formular una agenda de investigación para el futuro próximo. El trabajo "basado en una serie de estudios realizados en el marco del proyecto internacional Iniciativa Global para la Investigación Urbana (GURI, por sus siglas en inglés y aplicados en tres subregiones" hace un recuento del inicio y evolución de la investigación urbana en cada subregión; desarrolla aspectos como las perspectivas teóricas de la investigación urbana, los temas investigados, las disciplinas involucradas y las estructuras institucionales de apoyo a la investigación, poniendo énfasis, además, en el análisis comparativo de las subregiones (México-Colombia y Centroamérica; Brasil y Venezuela; los países andinos y del Cono Sur y en la importancia de los aspectos político-institucionales en el desarrollo de la investigación.

  3. Mobilidade urbana para pessoas com deficiência no Brasil: um estudo em blogs

    Directory of Open Access Journals (Sweden)

    Adriana Silva Barbosa

    2016-01-01

    Full Text Available A mobilidade urbana considera as condições de deslocamento das pessoas e bens pela cidade. O objetivo deste estudo é analisar como os blogs com a temática deficiência retratam a mobilidade urbana para pessoas com deficiência no Brasil. Para tanto, foi realizada uma pesquisa qualitativa e exploratória, na qual foram analisadas postagens de 15 blogs de pessoas com deficiência com o emprego da Grounded Theory. Reconhecer a mobilidade urbana como condição estratégica para a inclusão de pessoas com deficiência foi identificada como categoria central deste estudo, à qual se subordinam dezesseis subcategorias, organizadas em cinco eixos: necessidade de mudanças, sentimentos, efetivação da mudança, investimentos financeiros e consequências. Estes resultados mostram que a mobilidade urbana é considerada pelas pessoas com deficiência como estratégica para sua inclusão social e que os blogs evidenciam suas necessidades, reivindicações, reflexões, discussões e apontam soluções para os problemas que enfrentam em seu cotidiano.

  4. A paisagem urbana como produto do poder Urban landscape as a product of power

    Directory of Open Access Journals (Sweden)

    João Henrique Bonametti

    2010-11-01

    Full Text Available A investigação histórica proposta neste trabalho é a relação entre poder e paisagem urbana, a partir daabordagem histórico-conceitual sobre estes temas. Conceituou-se poder e paisagem e suas ações na sociedade,caracterizando as relações políticas. Buscou-se a compreensão de poder formulada por MichaelFoucault e Hobbes como o receptáculo de acontecimentos, em que a soberania controla para exercero poder. Abordam-se questões da relação paisagem urbana e poder, enquanto estruturadores do espaçoda cidade e os significados e contribuições da arquitetura e urbanismo neste processo de produção dapaisagem urbana como produto do poder. A interpelação de soberania com o espaço e sua atuação napaisagem urbana no decorrer da história da humanidade estabeleceu com o entorno um elo de sobrevivência,contemplação da natureza e vida em sociedade.

  5. Evaluation of the potential inhibitor of Ix (Pp-Ix) protoporphyrin of the genetic damage induced by gamma rays administered to different dose reasons in Drosophila melanogaster; Evaluacion del potencial inhibidor de la protoporfirina IX (PP-IX) del dano genetico inducido por rayos gama administrados a diferentes razones de dosis en Drosophila melanogaster

    Energy Technology Data Exchange (ETDEWEB)

    Flores A, J. A.

    2016-10-01

    Ionizing radiation can damage in DNA directly or indirectly by free radicals (Rl), characterized by unstable and highly reactive. To avoid damage by Rl the cell has endogenous antioxidants such as Sod, Cat, GSH or exogenous as some vitamins, but if with these mechanisms does not reach the cell homeostasis, the consequence may be the generation of chronic-disease degenerative such as cancer. This study was conducted in order to test the inhibitory role of Rl protoporphyrin Ix (Pp-Ix), induced by 20 Gy of gamma rays administered at different dose ratios using the assay of somatic mutation and recombination in the Drosophila wing. The results indicated that 20 Gy delivered at a rate of low dose (6.659 Gy/h), caused elevated frequencies of genetic damage (p <0.001), compared with those that induced a high dose reason (1111.42 Gy/h) in larvae of 48 h old. The difference is probably due to an indirect damage by Rl; when this hypothesis was approved with the possible inhibitor role of Pp-Ix (0.69 m M), damage was increased with the two reasons of tested doses. This result may be due to: 1) the Pp-Ix is not a good inhibitor of Rl, 2) the difference in the frequency of mutation found with both dose reasons, not due to Rl so that this compound did not reduce the genetic damage, and 3) that Pp-Ix acts as pro oxidant. (Author)

  6. Distribuição de Aglomerados Subnormais na Rede Urbana e nas Grandes Regiões Brasileiras

    OpenAIRE

    Vanessa Gapriotti Nadalin; Cleandro Krause; Vicente Correia Lima Neto

    2014-01-01

    A precariedade urbana e habitacional é heterogênea no Brasil, o que torna necessário fazer análises territoriais. Este trabalho analisa dados do Censo Demográfico 2010 relativos aos aglomerados subnormais (AS), buscando identificar comportamentos diferenciados nos municípios segundo uma rede urbana e sua inserção regional. Escolheu-se como classificação dos municípios brasileiros em rede urbana o estudo Regiões de Influência das Cidades 2007 (IBGE, 2008), ou REGIC, tendo sido encontradas quat...

  7. Impacto de la expansion urbana sobre la sustentabilidad ambiental del litoral de la bahia de huanchaco - peru

    OpenAIRE

    Bocanegra García, Carlos Alfredo

    2005-01-01

    Se presenta resultados del “Impacto de la expansión urbana sobre la sustentabilidad ambiental del litoral de la Bahía de Huanchaco-Perú“; los cuales están referidos a mostrar los principales indicadores de deterioro ambiental generado por el crecimiento poblacional y la presión urbana. Los resultados evidencian crecimiento acelerado de la población humana principalmente urbana la que mayormente se instaló en el litoral en desmedro de las áreas adyacentes caracterizadas por condiciones precari...

  8. Isla de calor y ocupación espacial urbana en San Juan, Argentina: análisis evolutivo

    OpenAIRE

    Papparelli, Alberto; Kurbán, Alejandra; Cúnsulo, Mario

    2013-01-01

    En este articulo se presentan resultados finales de un proyecto de investigacion bianual (2009-2010), denominado Variación histórica y espacial de la isla de calor urbana en zona árida, financiado por la Universidad Nacional de San Juan, Argentina. Su objetivo principal es determinar la progresiva modificacion de la isla de calor urbana en un periodo de quince anos (1995-2010) y la correlacion de esta con la ocupacion del area urbana del Gran San Juan (GSJ), localizada en la diagonal arida de...

  9. Bovine adenovirus type 3 containing heterologous protein in the C-terminus of minor capsid protein IX

    International Nuclear Information System (INIS)

    Zakhartchouk, Alexander; Connors, Wayne; Van Kessel, Andrew; Tikoo, Suresh Kumar

    2004-01-01

    Earlier, we detected pIX of BAdV-3 as a 14-kDa protein in purified virions. Analysis of BAdV-3 pIX using different region antibodies revealed that the N-terminus and central domain of the pIX contain immunogenic sites and are not exposed on the surface of BAdV-3 virion. This suggested that the C-terminus of BAdV-3 pIX (125 amino acid) may be exposed on the virion and may be used as a site for incorporation of heterologous peptides or proteins. We constructed recombinant BAV950 containing a small peptide (21 amino acid), including the RGD motif or recombinant BAV951 containing enhanced yellow-green fluorescent protein (EYFP) fused to the C-terminus of pIX. Western blot analysis demonstrated that the chimeric pIX-RGD was incorporated into virion capsids. Incorporation of the RGD motif into the pIX resulted in significant augmentation of BAdV-3 fiber knob-independent infection of the integrin-positive cells, suggesting that RGD motifs are displayed on the surface of virion capsids and are accessible for binding to integrins. Analysis of BAV951 revealed that the chimeric pIX is incorporated into virion capsids and EYFP containing the C-terminus of pIX is exposed on the surface of the virion. Moreover, insertion of chimeric pIXs was maintained without change through successive rounds of viral replication. These results suggested that in contrast to major capsid proteins (hexon, penton, fiber), the minor capsid protein IX can be use for the incorporation of targeting ligands based on either small peptides or longer polypeptides

  10. Effect of IX column maintenance on carbon-14 concentration in moderator systems

    International Nuclear Information System (INIS)

    Gallagher, C.L.; Tripple, A.W.

    2006-01-01

    The radionuclide 14 C is produced in CANDU reactors primarily by the (n,α) reaction with 17 O. Because of high neutron fluxes in the core, the majority of the 14 C (94.5%) is produced in the moderator. In the moderator system, 14 C is present mainly as CO 2 in the cover gas in dynamic equilibrium with dissolved carbonates, bicarbonates and CO 2 in the moderator water. Emissions of 14 C from reactors occur through venting or leakage of the cover gas. By controlling the dissolved carbonates in the moderator water with an ion exchange (IX) purification system, the amount of 14 C in the cover gas is minimized and thus the emissions of 14 C can be reduced. A study was conducted to measure the 14 C concentrations in the moderator system at Gentilly 2 in order to determine the effectiveness of the purification system in removing 14 C. Moderator water samples were obtained from the inlet and outlet of the purification system from 2004 January 14 to July 12, covering the operation of two IX columns (IX-1 and IX-3). The moderator water samples contained high levels of tritium (∼2 TBq·L -1 ). As both tritium and 14 C are β-radiation emitters, direct counting of moderator water for 14 C is impossible as the signal due to tritium dominates over that of other β-emitters. Therefore, a procedure developed by Caron et al. was used in this study, which involved acidifying the sample to release the dissolved 14 CO 2 as gas and collecting the 14 CO 2 in a base (NaOH), which could then be measured by liquid scintillation counting to determine the 14 C concentration. Both of the IX columns started with 14 C removal efficiencies of about 95%. The efficiency began to decrease almost immediately with the IX-1 column dropping to 80% efficiency after ∼1115 hours. This drop in efficiency also led to an increase in the inlet concentration over time. IX-1 column was removed from service after ∼1745 hours with a 14 C removal efficiency of ∼31%. IX-3 column was then placed in service

  11. Haemophilia B caused by mutation of a potential thrombin cleavage site in factor IX

    Energy Technology Data Exchange (ETDEWEB)

    Winship, P.R. (Univ. of Oxford (England))

    1990-03-11

    Haemophilia B is a blood coagulation disorder caused by mutations in the factor IX gene giving functionally defective or reduced levels of factor IX protein circulating in the plasma. The mutation in the Caucasian patient under investigation, Haemophilia B Oxford h5 (Oxh5), was characterized at the DNA level by constructing a genomic library using leucocyte-derived DNA from the patient. Overlapping recombinant clones spanning the entire factor IX locus were isolated which then allowed the generation of a series of sub-clones across all eight exons (a-h) plus the 5{prime} and 3{prime} flanking sequences known to be important in regulation of the gene and polyadenylation of the mRNA species.

  12. Rupturas na rede urbana e faces do mercado de trabalho

    Directory of Open Access Journals (Sweden)

    Denise Elias

    2012-07-01

    Full Text Available A mundialização do capital é um grande propulsor de divisão do trabalho. Ao potencializar as condições gerais de produção nas diversas escalas, agrega inúmeros novos espaços para a circulação e produção de bens. Isso repercute territorialmente numa desconcentração da produção, reafirmando cada vez mais a necessidade da divisão técnica e territorial do trabalho, bem como de uma nova maneira de organizá-lo, tendo em vista o fomento da produtividade. A reestruturação dos processos produtivos desencadeia mudanças diversas tanto na reprodução social como na organização do espaço geográfico. No Brasil, especialmente desde a década de 1980, muitos lugares tornam-se atrativos à produção moderna e são incorporados aos circuitos produtivos globalizados de empresas nacionais e multinacionais de diferentes ramos da economia. Entre os resultados, teríamos reestruturações econômicas e territoriais de várias naturezas e magnitudes, imprimindo novas características à rede urbana. No presente artigo temos como objetivo apresentar, a luz da conjuntura atual, alguns dos rebatimentos de tais processos materializados numa cidade de porte médio e respectiva região localizada no semiárido brasileiro. O destaque será dado à conformação da divisão técnica e territorial do trabalho, a partir de dados do mercado de trabalho formal. Abstract RUPTURES AT THE URBAN NETWORK AND FACES OF THE LABOR MARKET The Globalization of the capital is one of the greatest agents propelling the work division. By augmenting the general conditions of production in the diverse scales, it aggregates several new spaces to the circulation and production of goods. This reverberates territorially in the de-concentration of production, reaffirming more and more the need of a technical and territorial of work, as well as a new way of work organization, having in mind the encouragement of productivity. The restructuring of the productive processes

  13. Hubungan Gaya Kepemimpinan Orang Tua terhadap Hasil Belajar IPA Siswa Kelas IX SMPN 2 Batang Anai

    Directory of Open Access Journals (Sweden)

    Nelfi Erlinda

    2017-02-01

    Full Text Available AbstractPenelitian ini dilatarbelakangi oleh rendahnya hasil belajar IPA siswa kelas IX SMPN 2 Batang Anai. Faktor penyebabnya ada yang berasal dari dalam diri siswa dan dari luar diri siswa. Faktor yang berasal dari dalam diri siswa seperti malas belajar. Faktor luar diri siswa seperti faktor lingkungan keluarga yang terdiri dari faktor orang tua, suasana keluarga, lingkungan keluarga, kondisi keluarga yang tidak sehat atau broken home. Hal ini berpengaruh dalam proses belajar dan hasil belajar siswa di sekolah. Penelitian ini bertujuan untuk mengetahui hubungan gaya kepemimpinan orang tua terhadap hasil belajar IPA siswa kelas IX SMPN 2 Batang Anai. Jenis penelitian ini adalah penelitian deskriptif. Populasi penelitian adalah semua siswa kelas IX SMPN 2 Batang Anai yang terdaftar dalam tahun ajaran  2016/2017. Sampel penelitian adalah semua kelas IX SMPN 2 Batang Anai. Teknik pengambilan sampel menggunakan total sampling. Instrumen penelitian yang digunakan berupa angket atau kuesioner yang diberikan ke siswa. Teknik analisis data yang digunakan untuk menguji hipotesis adalah analisis korelasi dengan menggunakan uji chi kuadrat untuk melihat antara hubungan gaya kepemimpinan oramg tua dengan hasil belajar IPA siswa kelas IX SMPN 2 Batang Anai. Berdasarkan analisis data didapatkan dua gaya kepemimpimam yaitu otoriter dan demokratis. Hasil uji hipotesis diperoleh X2hitung < X2tabel = 0,004 < 3,841  sehingga hipotesis Ho diterima pada taraf nyata 0,05 dan hipotesis Hi ditolak. Jadi tidak ada hubungan yang berarti antara gaya kepemimpinan orang tua terhadap hasil belajar IPA siswa kelas IX SMPN 2 Batang Anai. Kata kunci :  Gaya kepemimpinan orang tua, hasil belajar.

  14. IX Jornadas de educación emocional. Educación emocional y valores

    OpenAIRE

    Barredo Gutiérrez, Blanca; Bisquerra Alzina, Rafael; Blanco Cuch, Aida; Giner, Antoni; Pérez Escoda, Núria; Tey, Amèlia

    2013-01-01

    Barredo Gutierrez, B.; Bisquerra Alzina, R.; Blanco Cuch, A.; Giner Tarrida, A.; Perez Escoda, N.; Tey Teijón, A. (eds.) IX Jornades d’educació emocional. Educació emocional i valors / IX Jornadas de educación emocional. Educación emocional y valores. Barcelona, Universitat de Barcelona (Institut de Ciències de l’Educació), 2013. Document electrònic.valores. Barcelona, Universitat de Barcelona (Institut de Ciències de l’Educació), 2013. Document electrònic

  15. Lacerations to Zones VIII and IX: It Is Not Just a Tendon Injury

    Directory of Open Access Journals (Sweden)

    Charla R. Fischer

    2011-01-01

    Full Text Available Extensor tendon injuries are widely believed to be straightforward problems that are relatively simple to manage. However, these injuries can be complex and demand a thorough understanding of anatomy to achieve the best functional outcomes. When lacerations occur in the forearm as in Zones VIII and IX injury, the repair of the extensor tendon and muscle, and posterior interosseous nerve (PIN is often challenging. A review of the literature shows little guidance and attention for these injuries. We present four patients with injuries to Zones VIII and IX as well as a review of surgical technique, postoperative rehabilitation, and pearls that may be of benefit to those managing these injuries.

  16. "To Study the Relationship of Academic Stress and Socio-Economic Status among IX Standard Students of Raipur City"

    Science.gov (United States)

    Khan, Suhail Ahmed; Ayyub, Khan Farhat

    2013-01-01

    This paper focuses on the relationship between academic stress and socio-economic status among IX standard students. The research was carried out in Raipur City (Chhattisgarh) on a sample of 600 IX standard students of English and Hindi medium schools. Academic Stress was measured by Stress Inventory for School Students prepared by Seema Rani…

  17. Correlation between macroscopic fluorescence and protoporphyrin IX content in psoriasis and actinic keratosis following application of aminolevulinic acid.

    NARCIS (Netherlands)

    Smits, T.; Robles, C.A.; Erp, P.E.J. van; Kerkhof, P.C.M. van de; Gerritsen, M.J.P.

    2005-01-01

    In fluorescence diagnosis with 5-aminolevulinic acid (ALA)-induced porphyrins (FDAP), protoporphyrin IX (PpIX) accumulation can be macroscopically visualized. Interpretation of these data is still problematic because of the low reproducibility of the procedure and poor understanding of the

  18. Somatic mosaicism and female-to-female transmission in a kindred with hemophilia B (factor IX deficiency)

    International Nuclear Information System (INIS)

    Taylor, S.A.M.; Deugau, K.V.; Lillicrap, D.P.

    1991-01-01

    Studies have shown that hemophilia B (Christmas disease; factor IX deficiency) results from many different mutations in the factor IX gene, of which >95% are single nulceotide substitutions. This study has identified a previously unreported form of hemophilia B in a patient who was a somatic mosaic for a guanine-to-cytosine transversion at nucleotide 31,170 in the factor IX gene. This point mutation changes the codon for residue 350 in the catalytic domain of factor IX from a cysteine to a serine. The authors used differential termination of primer extension to confirm and measure the degree of mosaicism. The study shows that a varying proportion of cells from hepatic, renal, smooth muscle, and hematopoietic populations possessed normal as well as mutant factor IX sequences. These results indicate that the mutation in this patient occurred either as an uncorrected half-chromatid mutation in the female gamete or as a replication or postreplication error in the initial mitotic divisions of the zygote preceding implantation. In addition, this kindred also contains two females in successive generations who have moderately severe factor IX deficiency. The molecular pathogenesis of this latter phenomenon has been studied and seems to relate to the unaccompanied expression of the mutant factor IX gene consequent upon a second, as yet undefined, genetic event that has prevented inactivation of sequences including the mutant factor IX gene on the X chromosome inherited from the affected male

  19. GESTÃO DA DRENAGEM URBANA NO BRASIL: DESAFIOS PARA A SUSTENTABILIDADE

    Directory of Open Access Journals (Sweden)

    Vladimir Caramori Borges de Souza

    2013-03-01

    Full Text Available Os sistemas de drenagem urbana no Brasil ainda seguem um padrão baseado apenas em eficiência hidráulica de condutos, apesar de já haver um reconhecimento de que este tipo de abordagem não resolve os problemas no longo prazo; é apenas uma ação pontual e que age sobre os efeitos. Desta forma, os sistemas de drenagem continuam sendo concebidos, dimensionados e projetados para falhar. Apesar de haver grande avanço acadêmico no desenvolvimento de técnicas e abordagens mais integradoras, com foco na bacia hidrográfica e nos impactos da urbanização sobre os processos naturais, ainda não houve apropriação desse conhecimento na prática dos técnicos municipais e tomadores de decisão. Este artigo apresenta uma contextualização da drenagem urbana no Brasil, mostrando os avanços obtidos no conhecimento do problema e os desafios para avançar, também, na aplicação de novas técnicas e metodologias. Foram analisados trabalhos acadêmicos desenvolvidos nos principais centros brasileiros de pesquisa em drenagem urbana – com foco em modelagem de sistemas de drenagem e desenvolvimento de técnicas compensatórias em drenagem urbana –, os principais instrumentos da política urbana e o conhecimento prático de análise de alguns sistemas de drenagem em particular. Observa-se que as incertezas nos parâmetros utilizados em projeto e modelagem ainda são grandes e os manuais utilizados estão defasados, com ausência de metodologias e parâmetros simples para utilização das novas técnicas e abordagens de drenagem urbana e manejo de águas pluviais.

  20. A novel mouse PKC{delta} splice variant, PKC{delta}IX, inhibits etoposide-induced apoptosis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jung D. [School of Biological Sciences, University of Ulsan, Ulsan (Korea, Republic of); Seo, Kwang W. [Department of Internal Medicines, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan (Korea, Republic of); Lee, Eun A.; Quang, Nguyen N. [School of Biological Sciences, University of Ulsan, Ulsan (Korea, Republic of); Cho, Hong R. [Department of Surgery, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan (Korea, Republic of); Biomedical Research Center, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan (Korea, Republic of); Kwon, Byungsuk, E-mail: bskwon@mail.ulsan.as.kr [School of Biological Sciences, University of Ulsan, Ulsan (Korea, Republic of); Biomedical Research Center, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan (Korea, Republic of)

    2011-07-01

    Highlights: {yields} A novel PKC{delta} isoform, named PKC{delta}IX, that lacks the C1 domain and the ATP-binding site is ubiquitously expressed. {yields} PKC{delta}IX inhibits etoposide-induced apoptosis. {yields} PKC{delta}IX may function as an endogenous dominant negative isoform for PKC{delta}. -- Abstract: Protein kinase C (PKC) {delta} plays an important role in cellular proliferation and apoptosis. The catalytic fragment of PKC{delta} generated by caspase-dependent cleavage is essential for the initiation of etoposide-induced apoptosis. In this study, we identified a novel mouse PKC{delta} isoform named PKC{delta}IX (Genebank Accession No. (HQ840432)). PKC{delta}IX is generated by alternative splicing and is ubiquitously expressed, as seen in its full-length PKC{delta}. PKC{delta}IX lacks the C1 domain, the caspase 3 cleavage site, and the ATP binding site but preserves an almost intact c-terminal catalytic domain and a nuclear localization signal (NLS). The structural characteristics of PKC{delta}IX provided a possibility that this PKC{delta} isozyme functions as a novel dominant-negative form for PKC{delta} due to its lack of the ATP-binding domain that is required for the kinase activity of PKC{delta}. Indeed, overexpression of PKC{delta}IX significantly inhibited etoposide-induced apoptosis in NIH3T3 cells. In addition, an in vitro kinase assay showed that recombinant PKC{delta}IX protein could competitively inhibit the kinase activity of PKC{delta}. We conclude that PKC{delta}IX can function as a natural dominant-negative inhibitor of PKC{delta}in vivo.

  1. Big Men on Campus: Administrative Response to Title IX and the Development of Women's Sports in the Big Ten Conference, 1972-1982

    Science.gov (United States)

    Ramsey, Jeffrey T.

    2014-01-01

    Signed into law in 1972, Title IX of the Education Amendments was designed to eliminate gender discrimination throughout the American educational system. Title IX applied to all educational programs at any level of schooling including admissions, financial aid, academic programs, and social organizations. However, Title IX has primarily been…

  2. Systemic component of protoporphyrin IX production in nude mouse skin upon topical application of aminolevulinic acid depends on the application conditions

    NARCIS (Netherlands)

    van den Akker, Johanna T. H. M.; Iani, Vladimir; Star, Willem M.; Sterenborg, Henricus J. C. M.; Moan, Johan

    2002-01-01

    Topical application of 5-aminolevulinic acid (ALA) for protoporphyrin IX (PpIX)-based photodynamic therapy of skin cancer is generally considered not to induce systemic side effects because PpIX is supposed to be formed locally. However, earlier studies with topically applied ALA have revealed that

  3. El Cementerio Central. Bogotá, la vida urbana y la muerte

    Directory of Open Access Journals (Sweden)

    José Antonio Amaya

    1998-01-01

    Full Text Available Oscar Iván Calvo Isaza, El Cementerio Central. Bogotá, la vida urbana y la muerte. Santafé de Bogotá: Tercer Mundo Editores / Observatorio de Cultura Urbana, Colección Académica, 1998, 153 págs. El libro recoge lo sustancial de la monografía de grado, idénticamente intitulada, que el autor sustentó en este Departamento de Historia en junio del presente año para optar por el título de historiador, bajo la dirección del profesor Bernardo Tovar Zambrano. Como lo prescribe la crítica histórica, aquí se reseña el original universitario, tanto más cuanto que en este caso la monografia presenta un texto más amplio y más reciente.

  4. La tendencia ambiental urbana en ciudades intermedias. Una propuesta metodológica

    Directory of Open Access Journals (Sweden)

    Pinzón Botero María Victoria

    2011-11-01

    Full Text Available Desde las últim as décadas, es evidente la preocupación m undial por los im pactos ambientales negativos que ponen en riesgo la sostenibilidad urbana y su calidad ambiental. Diferentes estudios exponen las variables más importantes para minim izar estos impactos ambientales, y en este sentido, este trabajo de investigación muestra cómo a partir de un diseño metodológico más sencillo con 27 variables am bientales estratégicas, es posible evaluar la tendencia am biental urbana de ciudades intermedias. Este grupo priorizado de variables trabajadas en el marco de una gestión compartida, orientará el desarrollo de la ciudad hacia una estructura territorial más sostenible, como reto para la planificación ambiental actual y con visión de futuro.

  5. Ecología Urbana: la Ciencia Interdisciplinaria del Planeta Ciudad

    Directory of Open Access Journals (Sweden)

    Fabio Angeoletto

    2015-01-01

    Full Text Available La urbanización global y masiva de los territorios es el más importante fenómeno ecológico de la actualidad. Los estándares de crecimiento urbano son determinantes para la conservación de la diversidad biológica, y asimismo para el grado de calidad de vida de las poblaciones urbanas. Contrariamente a la percepción de los biólogos y de otros académicos, de las ciudades como ambientes estériles y opuestos a la naturaleza, el reciente desarrollo de la ecología urbana, ciencia necesariamente interdisciplinaria, nos demuestra que ciudades son ecosistemas heterotróficos que necesitan ser planeados para que sus impactos en la biosfera sean disminuidos, y que en paralelo su capacidad de sostener la biodiversidad sea incrementada.

  6. Indicadores del servicio de acueducto y aglomeración urbana en Colombia

    Directory of Open Access Journals (Sweden)

    Pedro Ignacio Bernal

    2014-02-01

    Full Text Available El presente artículo revisa la relación entre la jerarquía territorial urbana y algunos indicadores de servicios públicos domiciliarios. Se estudian los informes anuales de la Superintendencia de Servicios, que no ofrecen una perspectiva espacial consistente. Sin embargo, con base en las evaluaciones integrales publicadas por esa entidad, se asignan ponderaciones y puntajes a algunos indicadores de prestación del servicio de acueducto, con el fin de analizar una muestra de 110 empresas. Los resultados muestran índices de servicio decrecientes en función de la posición en la jerarquía urbana (asociada con el número de suscriptores atendidos por las empresas. Estos resultados cuestionan la posición oficial que asevera que es la naturaleza jurídica de los prestadores la que determina los resultados.

  7. Serie Documentos Nº2 - Investigaciones en Antropología Urbana (U. Central de Chile

    Directory of Open Access Journals (Sweden)

    Verónica Tapia Barría

    2007-09-01

    Full Text Available Una de las características principales del desarrollo de la investigación antropológica urbana en Chile es justamente el hecho de constituirse como un espacio en construcción, que obedece más bien a un conjunto de esfuerzos independientes que a la formulación de programas de investigación formales. Dichos esfuerzos son mayormente protagonizados por investigadores jóvenes, que desde sus particulares ópticas y objetos de interés han ido perfilando el carácter de lo que podríamos denominar antropología urbana chilena.

  8. Transition properties of the Be-like X-ray from Mg IX

    Indian Academy of Sciences (India)

    Feng Hu

    2017-11-23

    Nov 23, 2017 ... Transition properties of the Be-like Kα X-ray from Mg IX. FENG HU1,3,∗ ... 1. Introduction. Magnesium is one of the most abundant elements in the. Universe, and its .... sion coefficients for the configuration state functions are optimized to ..... The absorption oscillator strengths ( fij) and radiative rate Aji for a ...

  9. Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

    Indian Academy of Sciences (India)

    In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the ... The self-bound state appears to be at ρ ... The observations suggest that the Hubble expansion of the Universe ... Taking motivation from.

  10. Suggestions for Local School District Compliance with Title IX Rules and Regulations.

    Science.gov (United States)

    Arizona State Dept. of Education, Phoenix.

    This guidebook is designed to help local districts determine how well they comply with the spirit of the Title IX requirements against sex discrimination, which in turn could aid in compliance with the letter of the law. The document's first section presents samples of required antidiscrimination policy statements issued by two districts. The…

  11. Two novel mutations in the PPIB gene cause a rare pedigree of osteogenesis imperfecta type IX.

    Science.gov (United States)

    Jiang, Yu; Pan, Jingxin; Guo, Dongwei; Zhang, Wei; Xie, Jie; Fang, Zishui; Guo, Chunmiao; Fang, Qun; Jiang, Weiying; Guo, Yibin

    2017-06-01

    Osteogenesis imperfecta (OI) is a rare genetic skeletal disorder characterized by increased bone fragility and vulnerability to fractures. PPIB is identified as a candidate gene for OI-IX, here we detect two pathogenic mutations in PPIB and analyze the genotype-phenotype correlation in a Chinese family with OI. Next-generation sequencing (NGS) was used to screen the whole exome of the parents of proband. Screening of variation frequency, evolutionary conservation comparisons, pathogenicity evaluation, and protein structure prediction were conducted to assess the pathogenicity of the novel mutations. Sanger sequencing was used to confirm the candidate variants. RTQ-PCR was used to analyze the PPIB gene expression. All mutant genes screened out by NGS were excluded except PPIB. Two novel heterozygous PPIB mutations (father, c.25A>G; mother, c.509G>A) were identified in relation to osteogenesis imperfecta type IX. Both mutations were predicted to be pathogenic by bioinformatics analysis and RTQ-PCR analysis revealed downregulated PPIB expression in the two carriers. We report a rare pedigree with an autosomal recessive osteogenesis imperfecta type IX (OI-IX) caused by two novel PPIB mutations identified for the first time in China. The current study expands our knowledge of PPIB mutations and their associated phenotypes, and provides new information on the genetic defects associated with this disease for clinical diagnosis. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Protoporphyrin IX formation and photobleaching in different layers of normal human skin

    DEFF Research Database (Denmark)

    Togsverd-Bo, Katrine; Idorn, Luise W; Philipsen, Peter A

    2012-01-01

    human skin was tape-stripped and incubated with 20% methylaminolevulinate (MAL) or 20% hexylaminolevulinate (HAL) for 3 h. Fluorescence microscopy quantified PpIX accumulation in epidermis, superficial, mid and deep dermis, down to 2 mm. PpIX photobleaching by light-emitting diode (LED, 632 nm, 18......Topical photodynamic therapy (PDT) is used for various skin disorders, and selective targeting of specific skin structures is desirable. The objective was to assess accumulation of PpIX fluorescence and photobleaching within skin layers using different photosensitizers and light sources. Normal...... and 37 J/cm(2)), intense pulsed light (IPL, 500-650 nm, 36 and 72 J/cm(2)) and long-pulsed dye laser (LPDL, 595 nm, 7.5 and 15 J/cm(2)) was measured using fluorescence photography and microscopy. We found higher PpIX fluorescence intensities in epidermis and superficial dermis in HAL-incubated skin than...

  13. Kinetic data bank for Ramona of the Siemens 9x9-IX

    International Nuclear Information System (INIS)

    Alonso V, G.

    1993-12-01

    With the purpose of making the transitory analyses of the Laguna Verde Nuclear Power station when Siemens fuel of the type 9x9-IX is used, proposed for the cycle 2 of the Unit 2, the kinetic data bank in hot condition for the Ramona code has been generated. (Author)

  14. Japanese contributions to IAEA INTOR workshop, phase two A, part 2, chapter IX: engineering

    International Nuclear Information System (INIS)

    Iida, Hiromasa; Seki, Masahiro; Sawada, Yoshio

    1985-07-01

    This report corresponds to Chapter IX of Japanese contribution report to IAEA INTOR Workshop, Phase Two A, Part 2. Data base assessment are made for systems engineering, magnet systems, torus systems, and NBI heating systems. R and D programme and impact on INTOR design are also specified. In addition to the data base assessment, studies have been made for several new tasks. (author)

  15. Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

    Indian Academy of Sciences (India)

    In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the context of general relativity are explored. To obtain deterministic solution of the Einstein's field equations, various techniques are adopted. The features of the obtained solution are discussed.

  16. Sex Discrimination and Intercollegiate Athletics: Putting Some Muscle on Title IX.

    Science.gov (United States)

    Yale Law Journal, 1979

    1979-01-01

    Argues that the general language of the Title IX statute, together with certain specific features of it, strongly suggests that the Department of Health, Education, and Welfare should develop more stringent and demanding regulations based on social policy considerations concerning sex discrimination in intercollegiate sports. Available from Yale…

  17. The Fourth Circuit Kicks a Hole through the Contact-Sport Exception to Title IX.

    Science.gov (United States)

    Puszczewicz, James

    2000-01-01

    Discusses a recent Fourth Circuit Court of Appeals decision that when individuals are allowed to try out for or join a team participating in a contact sport and operated for members of the other sex, then discrimination against because of their sex is prohibited by Title IX. (22 footnotes) (MLF)

  18. Title IX: Does Help for Women Come at the Expense of African Americans?

    Science.gov (United States)

    Greenlee, Craig T.

    1997-01-01

    Federal law that forbids sex discrimination in educational institutions receiving federal funds (Title IX) has created opportunities for women athletes, but some say men's sports have lost ground. Since athletics provide major educational opportunities for black men, less so for black women, critics are concerned blacks may be losing. (MSE)

  19. Comparison of nitric oxide binding to different pure and mixed protoporphyrin IX monolayers

    NARCIS (Netherlands)

    Knoben, W.; Crego-Calama, M.; Brongersma, S.H.

    2012-01-01

    The nitric oxide (NO) binding properties of monolayers of four different protoporphyrins IX adsorbed on aluminum oxide surfaces have been investigated. XPS and AFM results are consistent with the presence of a monolayer of porphyrins, bound to the surface by their carboxylic acid groups and with the

  20. Title IX, Girls' Sports Participation, and Adult Female Physical Activity and Weight

    Science.gov (United States)

    Kaestner, Robert; Xu, Xin

    2010-01-01

    Arguably, the most important school-based intervention to increase physical activity was Title IX of the Education Amendments of 1972, which led to a 600% increase in girls' sports participation between 1972 and 1978. We studied the effect of this increase in sports participation and athletic opportunities while young on the physical activity and…

  1. One of Gibbs's ideas that has gone unnoticed (comment on chapter IX of his classic book)

    International Nuclear Information System (INIS)

    Sukhanov, Alexander D; Rudoi, Yurii G

    2006-01-01

    We show that contrary to the commonly accepted view, Chapter IX of Gibbs's book [1] contains the prolegomena to a macroscopic statistical theory that is qualitatively different from his own microscopic statistical mechanics. The formulas obtained by Gibbs were the first results in the history of physics related to the theory of fluctuations in any macroparameters, including temperature. (from the history of physics)

  2. The Future of Electronic Power Processing and Conversion: Highlights from FEPPCON IX

    DEFF Research Database (Denmark)

    Enslin, Johan H.; Blaabjerg, Frede; Tan, Don F.D.

    2017-01-01

    Since 1991, every second year the IEEE Power Electronics Society (PELS) has organized the technical long-range planning meeting "Future of Electronic Power Processing and Conversion" (FEPPCON). FEPPCON IX was held 12-16 June 2017 in beautiful Kruger Park in South Africa (Figure 1). The overall go...

  3. Singlet oxygen feedback delayed fluorescence of protoporphyrin IX in organic solutions.

    Science.gov (United States)

    Vinklárek, Ivo S; Scholz, Marek; Dědic, Roman; Hála, Jan

    2017-04-12

    Delayed fluorescence (DF) of protoporphyrin IX (PpIX) has been recently proposed as a tool for monitoring of mitochondrial oxygen tension in vivo as well as for observation of the effectiveness of photodynamic therapy (PDT) [E. G. Mik, Anesth. Analg., 2013, 117, 834-346; F. Piffaretti et al., J. Biomed. Opt., 2012, 17, 115007]. However, the efficiency of the mechanism of thermal activation (E-type DF), which was considered in the papers, is limited due to a large energy gap between the first excited singlet and the first triplet state of PpIX at room or body temperatures. Moreover, the energy gap is roughly equal to other porphyrinoid photosensitizers that generate DF mostly through the Singlet Oxygen Feedback-Induced mechanism (SOFDF) under certain conditions [M. Scholz and R. Dědic, Singlet Oxygen: Applications in Biosciences and Nanosciences, 2016, vol. 2, pp. 63-81]. The mechanisms of delayed fluorescence of PpIX dissolved either in dimethylformamide (DMF) or in the mixture of DMF with ethylene glycol (EG) were investigated at atmospheric partial pressure of oxygen by means of a simultaneous time-resolved detection of 1 O 2 phosphorescence and PpIX DF which makes a direct comparison of the kinetics and lifetimes of both the luminescence channels possible. Samples of PpIX (100 μM) exhibit concave DF kinetics, which is a typical footprint of the SOFDF mechanism. The dramatic decrease in the DF intensity after adding a selective 1 O 2 quencher sodium azide (NaN 3 , 10 mM) proves that >90% of DF is indeed generated through SOFDF. Moreover, the analysis of the DF kinetics in the presence of NaN 3 implies that the second significant mechanism of DF generation is the triplet-triplet annihilation (P-type DF). The bimolecular mechanism of DF was further confirmed by the decrease of the DF intensity in the more viscous mixture DMF/EG and by the increase of the ratio of DF to the prompt fluorescence (PF) intensity with the increasing excitation intensity. These results

  4. Construir la ciudad. Interface entre política urbana y finanzas públicas locales

    Directory of Open Access Journals (Sweden)

    Mercedes Ferrer

    2005-01-01

    Full Text Available El objeto de este trabajo es identificar las fuentes de financiamiento de las políticas urbanas en la Alcaldía de Maracaibo y los cambios producidos en éstas durante el periodo 1989 al 2001. Para conocer la relación entre finanzas públicas y políticas urbanas se revisaron y contrastaron los Planes de Gestión Local con los Presupuestos Anuales y las Memorias y Cuenta y, se entrevistaron a funcionarios de las Direcciones de Planificación, Presupuesto y Rentas de la Alcaldía. Como resultado de la investigación realizada se identificaron dos cambios en el manejo de las finanzas locales - en la estructura de ingresos de la Alcaldía y en el mayor peso dado al financiamiento de las políticas urbanas - y, dos conclusiones básicas: la existencia de una política de inversión de las finanzas públicas locales que privilegia la construcción de la ciudad o ejecución de las políticas urbanas y, segundo, la búsqueda de nuevas fuentes de financiación tanto locales como nacionales e internacionales, para concretar dicha política. La estrategia implantada por los alcaldes durante el periodo analizado se apoya en una visión y praxis corporativa de la Alcaldía de Maracaibo dirigida a fortalecer una gestión visible, cuyo objetivo es impactar a corto plazo la calidad de vida de los ciudadanos para relegitimarse políticamente (marketing político, ampliar el espacio público y la gobernabilidad local.

  5. OS DOIS CIRCUITOS DA ECONOMIA URBANA EM JOÃO CÃMARAlRN, BRASIL

    Directory of Open Access Journals (Sweden)

    Aldo Dantas

    2012-01-01

    Full Text Available Desde finales de 1980 la dinámica territorial de João Câmara entra en una nueva fase en la que los circuitos de la economía urbana son, cada vez más predominante de la suya organización espacial, especialmente en medida que avance el consumo intenso de todas las capas de la sociedad. Por lo tanto, el objetivo de este estudio es analisar la expansión de los dos circuitos de la economía urbana en la ciudad de João Câmara, com énfasis en la suya actual configuración espacial, así como los factores que vengan a influenciar esa expansión de la ciudad. Así, hemos echo una recogida de datos a partir de fuentes y procedimientos. En el paso con respecto a las fuentes, hemos echo una busca bibliográfica y de documentación sobre algunos temas relacionados en cuestión en las bibliotecas y en las instituiciones públicas y privadas. En lo que se refiere a los procedimientos, o a la producción de informaciones, hemos realizado entrevistas y cuestionarios con los principales actores sociales envolucrados en los dos circuitos de la economía urbana en la ciudad de João Câmara. Los resultados obtenidos hasta ahora indican que la economía urbana de João Câmara se ha expandido, com una mayor intensidad, a partir de su circuito inferior, especialmente com respecto a las pequeñas empresas y establecimientos de servicios que se hacen presentes en los diferentes subespacios de la ciudad.

  6. Effect of PpIX photoproducts formation on pO2 measurement by time-resolved delayed fluorescence spectroscopy of PpIX in solution and in vivo.

    Science.gov (United States)

    Huntosova, Veronika; Gerelli, Emmanuel; Zellweger, Matthieu; Wagnières, Georges

    2016-11-01

    The measurement of Protoporphyrin IX delayed fluorescence lifetime is a minimally invasive method for monitoring the levels of oxygen in cells and tissues. The excitation of Protoporphyrin IX during this measurement can lead to the formation of photoproducts in vitro and in vivo. The influence of their luminescence on the measured Protoporphyrin IX delayed fluorescence lifetimes was studied in solution and in vivo on the Chick's chorioallantoic membrane (CAM) model under various oxygen enriched air conditions (0mmHg, 37mmHg and 155mmHg). The presence of photoproducts disturbs such measurements since the delayed fluorescence emission of some of them spectrally overlaps with that of Protoporphyrin IX. One possible way to avoid this obstacle is to detect Protoporphyrin IX's delayed fluorescence lifetime in a very specific spectral range (620-640nm). Another possibility is to excite Protoporphyrin IX with light doses much lower than 10J/cm 2 , quite possibly as low as a fraction 1J/cm 2 at 405nm. This leads to an increased accuracy of pO 2 detection. Furthermore, this method allows combination of diagnosis and therapy in one step. This helps to improve detection systems and real-time identification of tissue respiration, which is tuned for the detection of PpIX luminescence and not its photoproducts. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Action of the protoporphyrin-Ix (Pp-Ix) in the life period of Drosophila mutants deficient in endogenous antioxidants; Accion de la protoporfirina-IX (PP-IX) en el periodo de vida de mutantes de Drosophila deficientes en antioxidantes endogenos

    Energy Technology Data Exchange (ETDEWEB)

    Vidal E, L. M.

    2012-07-01

    The human being is daily exposed to free radicals or reactive oxygen species (Ros), as a result of the breathing and the interactions with xenobiotics that can cause irreversible lesions in molecules and cellular structures and that they are associated to diseases like the cancer, neuro degenerative and to the acceleration of the normal process of aging. Fortunately, to reduce the damaging effect of the Ros the cell has endogenous antioxidant systems constituted by antioxidant enzymes as: the superoxide dismutase (Sod), the catalase (Cat), and the glutathione peroxidase and reductase. Even, when these systems are not enough, we find to the exogenous antioxidants that cooperate in the balance of the Ros, as the porphyrins that include to the chlorophyllin, the hemin and the bilirubin among others. The protoporphyrin-Ix (Pp-Ix) is a tetra pyrrole without metallic center with antimutagenic and antioxidant activity similar to that of the chlorophyllin. However, is also known that their over-expression has toxic effects, because induces Ros. In Drosophila melanogaster, recently was found that the Pp-Ix have dual action anti and persistent mutagenic. One of their possible mechanism to act like mutagen is through the Ros induction. To evaluate this possibility and based in that the increase in the Ros levels can accelerate the aging process, in the present work the Pp-Ix role was evaluated, in the life period of Drosophila melanogaster strains deficient in Sod and Cat, sensitive to radiation or oxidative stress (rad, whd and flr{sup 3}) and a wild one as control (C-S). Females and males of each strain were treated chronically for separate with sucrose or Pp-Ix and every 15 days a group of each sex was irradiated with 10 Gy of gamma rays. The results indicated that the chronic treatment with Pp-Ix and in combination with radiation, increased the life period of the C-S strain. The Sod strain had a contrary effect and this effect was pronounced with the combined treatment of

  8. Redes urbanas y sistema de ciudades de Alemania. Algunas precisiones cara al Siglo XXI

    Directory of Open Access Journals (Sweden)

    José María Serrano Martínez

    2000-01-01

    Full Text Available El camino recorrido por Alemania ha sido el inverso al de otros países; aquí las ciudades han sido la base que ha permitido construir el país. Ello se advierte al estudiar la jerarquía urbana nacional y también en la propia organización singular de las redes urbanas regionales. Cada «Länder» ha conseguido un subsistema urbano bastante autónomo. Ahora bien, su elevada densidad de población —irregularmente distribuida—, y los apreciables desajustes socio-económicos territoriales, son aspectos que trasladan su influencia a la desigualdad territorial existente; eso acentúa la carencia de equilibrio de su malla urbana. Acaso el proceso de reunificación puede suponer un camino que introduzca apreciables cambios, tendentes hacia una mayor integración y equilibrio del conjunto del sistema urbano alemán.

  9. Hierarchical coassembly of DNA–triptycene hybrid molecular building blocks and zinc protoporphyrin IX

    Directory of Open Access Journals (Sweden)

    Rina Kumari

    2016-05-01

    Full Text Available Herein, we describe the successful construction of composite DNA nanostructures by the self-assembly of complementary symmetrical 2,6,14-triptycenetripropiolic acid (TPA–DNA building blocks and zinc protoporphyrin IX (Zn PpIX. DNA–organic molecule scaffolds for the composite DNA nanostructure were constructed through covalent conjugation of TPA with 5′-C12-amine-terminated modified single strand DNA (ssDNA and its complementary strand. The repeated covalent conjugation of TPA with DNA was confirmed by using denaturing polyacrylamide gel electrophoresis (PAGE, reverse-phase high-performance liquid chromatography (RP-HPLC and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF. The biologically relevant photosensitizer Zn PpIX was used to direct the hybridization-mediated self-assembly of DNA–TPA molecular building blocks as well as a model guest molecule within the DNA–TPA supramolecular self-assembly. The formation of fiber-like composite DNA nanostructures was observed. Native PAGE, circular dichroism (CD and atomic force microscopy (AFM have been utilized for analyzing the formation of DNA nanofibers after the coassembly. Computational methods were applied to discern the theoretical dimension of the DNA–TPA molecular building block of the nanofibers. A notable change in photocatalytic efficiency of Zn PpIX was observed when it was inside the TPA–DNA scaffold. The significant increase in ROS generation by Zn PpIX when trapped in this biocompatible DNA–TPA hybrid nanofiber may be an effective tool to explore photodynamic therapy (PDT applications as well as photocatalytic reactions.

  10. Viabilidad para la implementación de estrategias de renovación urbana en Costa Rica

    Directory of Open Access Journals (Sweden)

    Dania Chavarría Núñez

    2017-01-01

    Full Text Available En los últimos años se han realizado en Costa Rica algunos esfuerzos para desarrollar normativa urbana que facilite la intervención dentro de las ciudades existentes, con el fin de revitalizar los centros urbanos y atraer nuevamente a la población que por diversas causas renunció a vivir en la ciudad. Las estrategias de Renovación Urbana han desempeñado un papel importante en las transformaciones socio-espaciales que han experimentado muchas ciudades del mundo, las cuales incorporan herramientas novedosas para intervenir dentro del entorno construido y contemplan una serie de instrumentos que permiten corregir las tendencias negativas que genera el modelo de ciudad dispersa, y a su vez devolver la funcionalidad y el atractivo a sectores estratégicos con el fin de construir un nuevo modelo de ciudad más sostenible e inclusiva. El presente artículo tiene como propósito analizar las posibilidades que existen en el país para implementar estrategias de renovación urbana, tomando como marco base la legislación urbana existente. Con el fin de evidenciar este supuesto se analiza la normativa vigente y se pone en evidencia como dicha legislación faculta a los municipios para ejercer competencias en la planificación urbana y el ordenamiento de su territorio. Se da un énfasis particular a la viabilidad para desarrollar e implementar estrategias de renovación urbana en la escala local, la cual se fundamenta en la Ley de Planificación urbana 4240 y se fortalece con los avances más recientes que se han dado en el país en materia de actualización normativa.

  11. ÍNDICE DE DIVERSIDAD BIOLÓGICA URBANA DE LA CIUDAD DE LA ANTIGUA GUATEMALA

    Directory of Open Access Journals (Sweden)

    Jorge José García Polo

    2016-08-01

    Full Text Available La urbanización es un fenómeno global de tendencia creciente, cuyo pronóstico prevé, para el 2050, que aproximadamente el 70% de la población mundial será urbana. Las administraciones municipales deben de contemplar este componente para la planificación y desempeño ambiental de sus ciudades y áreas urbanas. Dada la importancia de esta tendencia,  el Convenio para la Diversidad Biológica (CDB ha planteado una nueva herramienta para estimar la diversidad biológica en ciudades: el Índice de Diversidad Biológica Urbana. En este proyecto se evaluó el índice para la ciudad de La Antigua Guatemala en su línea base y se aportan elementos para la planificación y gestión ambiental,  midiendose dieciocho indicadores de biodiversidad urbana. De un máximo de 72 puntos, el resultado para la ciudad de La Antigua Guatemala fue de 33 puntos. Los registros para la línea base de la biodiversidad son: 99 especies de aves, 148 especies de plantas vasculares, 46 especies de mariposas y 11 especies de murciélagos. Las recomendaciones para tener un mejor desempeño en el tema de diversidad biológica están relacionadas con la urgente necesidad que la ciudad, previo a la próxima evaluación del índice, elabore la estrategia local de diversidad biológica y su plan de acción (LBSAP – por sus siglas en inglés. Se recomienda, además,  planificar e implementar proyectos de gestión ambiental y continuar utilizando el índice de diversidad biológica urbana para el monitoreo y evaluación del desempeño ambiental de la ciudad a largo plazo.

  12. Anatomía de la dispersión urbana en Barcelona

    Directory of Open Access Journals (Sweden)

    Iván Muñiz

    2013-01-01

    Full Text Available No existe una definición comúnmente aceptada de dispersión urbana (urban sprawl, de modo que la investigación aplicada ha trabajado con diferentes indicadores que pretenden a su vez capturar los distintos significados con que se ha dotado al término. En este trabajo se mide cómo ha evolucionado la dispersión de la población y del empleo de la Región Metropolitana de Barcelona (RMB entre 1986 y 2001. Las dimensiones exploradas se dividen en dos grupos: i forma urbana (desconcentración, baja densidad y discontinuidad y ii estructura urbana. A diferencia de algunos trabajos donde el policentrismo y el crecimiento lineal se presentan como dos formas de dispersión, en nuestro caso contraponemos la idea de expansión urbana estructurada (lineal o policéntrica con la de expansión urbana desestructurada (amorfa, caótica o aleatoria, equiparando esta última con la cuarta dimensión de la dispersión. Los resultados obtenidos indican que la población y el empleo de la RMB se han descentralizado de forma desconcentrada y la densidad residencial se ha reducido. Sin embargo, la RMB no ha crecido de forma discontinua ni desestructurada, sino todo lo contrario.There is no commonly accepted definition of urban sprawl, and therefore applied research has worked with different indicators aiming to grasp the diverse meanings assigned to the term. This study measures how the dispersion of population and employment in the Barcelona Metropolitan Region (BMR developed between 1986 and 2001. The dimensions that were investigated are divided into two groups. The first one involves dimensions of urban form (decentralization, low density and discontinuity, and the second, of urban structure. As opposed to some studies, where polycentrism and linear growth are presented as two forms of sprawl, in our case we contrast the idea of structured urban expansion (linear or poly-centric with de structured urban expansion (amorphous, chaotic or random, identifying

  13. La vulnerabilidad en el Área Urbana de Madrid. 1991-2001

    Directory of Open Access Journals (Sweden)

    Iván Rodríguez Suárez

    2013-04-01

    Full Text Available ResumenEste artículo analiza la evolución de las áreas con población vulnerable y la segregación residencial del Área Urbana de Madrid (AUM entre los años 1991 y 2001. La investigación se realiza mediante el análisis de dos índices utilizados anteriormente en la medición de la desigualdad urbana y la segregación espacial (HERNÁNDEZ AJA, 2009: el índice de población analfabeta y sin estudios, y el índice de viviendas sin retrete o cuarto de aseo. En el periodo de estudio observado ambos índices experimentaron mejoras significativas en escalas de agregación espacial nacional, regional o de área urbana (INE, 2004. Sin embargo, en este trabajo se refleja que la distribución de estas mejoras a escalas municipales e inframunicipales no es homogénea: en este periodo se incrementaron los desequilibrios internos en el AUM y éstos responden a patrones espaciales diferenciados para los municipios de la corona metropolitana y el municipio central del AUM.Palabras claveVulnerabilidad urbana, segregación residencial, áreas metropolitanas, geografía urbana de la desigualdad, corona metropolitana.AbstractThis article analyzes the evolution of vulnerable areas and residential segregation in Madrid Urban Area (AUM between 1991 and 2001. Research is conducted by analyzing two indices previously used in measuring urban inequality and spatial segregation (HERNÁNDEZ AJA, 2009: the rate of illiterate and uneducated population, and the rate of households without toilet or shower room. In the study period observed both indices experienced significant improvements in spatial aggregation scales of national, regional or urban areas (INE, 2004. However, this paper shows that the distribution of these improvements to municipal and inframunicipal scales is not homogeneous: in this period increased internal imbalances in AUM and they respond to different spatial patterns for the municipalities of the metropolitan and AUM central municipality

  14. ¿Quién parte y reparte? Análisis de la disposición urbana en la Cartago fenicia

    Directory of Open Access Journals (Sweden)

    Fumadó Ortega, Iván

    2013-12-01

    el cruce entre el decumano máximo y el cardo x este, e intentaré sintetizar el estado de la cuestión actual sobre la forma urbana de la Cartago fenicia. A continuación repasaré algunos ejemplos de segmentación ortogonal de espacios urbanos documentados en el Próximo Oriente antiguo. Ello nos ayudará a suponer cuál habría sido el contexto técnico y práctico en que vivieron las sociedades fenicias de los siglos IX-VIII a.C. y, más concretamente, el contexto sociopolítico de los fundadores de Cartago. Por último y a la luz de estos elementos, presentaré una propuesta de reconstrucción de la forma urbana de la Cartago fenicia.

  15. O Estatuto da Cidade e a democratização das políticas urbanas no Brasil

    Directory of Open Access Journals (Sweden)

    Leonardo Avritzer

    2012-11-01

    Full Text Available O Brasil tem passado por um fortíssimo movimento de democratização do acesso a terra urbana e de regulamentação do uso da mesma. A origem destes processos está na organização do movimento pela reforma urbana nos anos 80 e sua atuação com êxito na Assembléia Nacional Constituinte. Neste artigo, iremos em primeiro lugar discutir a emergência e as principais características do movimento da reforma urbana no Brasil. Analisamos em detalhe como a relação entre as associações da sociedade civil e os atores políticos foi se modificando durante a luta pela reforma urbana no Brasil. Em segundo lugar, mostramos como a participação surgiu no campo das lutas pela reforma urbana e como ela gerou uma legislação participativa sobre o assunto ao longo do período da formulação da Constituição e no período imediatamente posterior. Em terceiro lugar, mostramos como o requisito de Planos Diretores Urbanos foi implementado nas cidades de São Paulo, Belo Horizonte, Porto Alegre e Salvador.

  16. Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer.

    Science.gov (United States)

    Buchlis, George; Podsakoff, Gregory M; Radu, Antonetta; Hawk, Sarah M; Flake, Alan W; Mingozzi, Federico; High, Katherine A

    2012-03-29

    In previous work we transferred a human factor IX-encoding adeno-associated viral vector (AAV) into skeletal muscle of men with severe hemophilia B. Biopsy of injected muscle up to 1 year after vector injection showed evidence of gene transfer by Southern blot and of protein expression by IHC and immunofluorescent staining. Although the procedure appeared safe, circulating F.IX levels remained subtherapeutic (< 1%). Recently, we obtained muscle tissue from a subject injected 10 years earlier who died of causes unrelated to gene transfer. Using Western blot, IHC, and immunofluorescent staining, we show persistent factor IX expression in injected muscle tissue. F.IX transcripts were detected in injected skeletal muscle using RT-PCR, and isolated whole genomic DNA tested positive for the presence of the transferred AAV vector sequence. This is the longest reported transgene expression to date from a parenterally administered AAV vector, with broad implications for the future of muscle-directed gene transfer.

  17. Tipos de estrutura urbana e consumo de água, análise da morfologia urbana na Bacia Hidrográfica do Riacho Fundo

    OpenAIRE

    Sotero, Marília Serena Porto

    2014-01-01

    Tipos de Estrutura Urbana (UST) são unidades espaciais mínimas que possuem certa homogeneidade no tipo de cobertura, uso e acesso a ecosserviços. Nesse trabalho o conceito de UST é aplicado a partir da classificação visual manual de fotografias aéreas e análises in situ. O objetivo do trabalho foi mapear classes UST na região intraurbana da Bacia Hidrográfica do Riacho Fundo, no Distrito Federal/Brasil, e analisar essa base comparando-a a variáveis socioeconômicas e dados de consumo de água. ...

  18. In Vivo Gene Therapy of Hemophilia B: Sustained Partial Correction in Factor IX-Deficient Dogs

    Science.gov (United States)

    Kay, Mark A.; Rothenberg, Steven; Landen, Charles N.; Bellinger, Dwight A.; Leland, Frances; Toman, Carol; Finegold, Milton; Thompson, Arthur R.; Read, M. S.; Brinkhous, Kenneth M.; Woo, Savio L. C.

    1993-10-01

    The liver represents a model organ for gene therapy. A method has been developed for hepatic gene transfer in vivo by the direct infusion of recombinant retroviral vectors into the portal vasculature, which results in the persistent expression of exogenous genes. To determine if these technologies are applicable for the treatment of hemophilia B patients, preclinical efficacy studies were done in a hemophilia B dog model. When the canine factor IX complementary DNA was transduced directly into the hepatocytes of affected dogs in vivo, the animals constitutively expressed low levels of canine factor IX for more than 5 months. Persistent expression of the clotting. factor resulted in reductions of whole blood clotting and partial thromboplastin times of the treated animals. Thus, long-term treatment of hemophilia B patients may be feasible by direct hepatic gene therapy in vivo.

  19. Compact invariant sets of the Bianchi VIII and Bianchi IX Hamiltonian systems

    International Nuclear Information System (INIS)

    Starkov, Konstantin E.

    2011-01-01

    In this Letter we prove that all compact invariant sets of the Bianchi VIII Hamiltonian system are contained in the set described by several simple linear equalities and inequalities. Moreover, we describe invariant domains in which the phase flow of this system has no recurrence property and show that there are no periodic orbits and neither homoclinic, nor heteroclinic orbits contained in the zero level set of its Hamiltonian. Similar results are obtained for the Bianchi IX Hamiltonian system. -- Highlights: → Zero level set of Hamiltonian of Bianchi VIII/IX systems contains no periodic orbits. → Similar conditions for homoclinic/heteroclinic orbits are given. → General nonexistence conditions of compact invariant sets are got.

  20. Compact invariant sets of the Bianchi VIII and Bianchi IX Hamiltonian systems

    Energy Technology Data Exchange (ETDEWEB)

    Starkov, Konstantin E., E-mail: konst@citedi.mx [CITEDI-IPN, Av. del Parque 1310, Mesa de Otay, Tijuana, BC (Mexico)

    2011-08-22

    In this Letter we prove that all compact invariant sets of the Bianchi VIII Hamiltonian system are contained in the set described by several simple linear equalities and inequalities. Moreover, we describe invariant domains in which the phase flow of this system has no recurrence property and show that there are no periodic orbits and neither homoclinic, nor heteroclinic orbits contained in the zero level set of its Hamiltonian. Similar results are obtained for the Bianchi IX Hamiltonian system. -- Highlights: → Zero level set of Hamiltonian of Bianchi VIII/IX systems contains no periodic orbits. → Similar conditions for homoclinic/heteroclinic orbits are given. → General nonexistence conditions of compact invariant sets are got.

  1. Operational Lessons Learned from the Ares I-X Flight Test

    Science.gov (United States)

    Davis, Stephan R.

    2010-01-01

    The Ares I-X flight test, launched in 2009, is the first test of the Ares I crew launch vehicle. This development flight test evaluated the flight dynamics, roll control, and separation events, but also provided early insights into logistical, stacking, launch, and recovery operations for Ares I. Operational lessons will be especially important for NASA as the agency makes the transition from the Space Shuttle to the Constellation Program, which is designed to be less labor-intensive. The mission team itself comprised only 700 individuals over the life of the project compared to the thousands involved in Shuttle and Apollo missions; while missions to and beyond low-Earth orbit obviously will require additional personnel, this lean approach will serve as a model for future Constellation missions. To prepare for Ares I-X, vehicle stacking and launch infrastructure had to be modified at Kennedy Space Center's Vehicle Assembly Building (VAB) as well as Launch Complex (LC) 39B. In the VAB, several platforms and other structures designed for the Shuttle s configuration had to be removed to accommodate the in-line, much taller Ares I-X. Vehicle preparation activities resulted in delays, but also in lessons learned for ground operations personnel, including hardware deliveries, cable routing, transferred work and custodial paperwork. Ares I-X also proved to be a resource challenge, as individuals and ground service equipment (GSE) supporting the mission also were required for Shuttle or Atlas V operations at LC 40/41 at Cape Canaveral Air Force Station. At LC 39B, several Shuttle-specific access arms were removed and others were added to accommodate the in-line Ares vehicle. Ground command, control, and communication (GC3) hardware was incorporated into the Mobile Launcher Platform (MLP). The lightning protection system at LC 39B was replaced by a trio of 600-foot-tall towers connected by a catenary wire to account for the much greater height of the vehicle. Like Shuttle

  2. Revisitation of chaos in Bianchi IX Universe and in generalized scalar-tensor cosmologies

    International Nuclear Information System (INIS)

    Lehner, Thierry; Di Menza, Laurent

    2003-01-01

    We show that there is a threshold for the onset of chaos in cosmology for the Universe described as a dynamical system derived from the Einstein equations of general relativity (GR). In the case of the mixmaster model (homogeneous and anisotropic cosmology with a Bianchi IX metric) the chaos occurs precisely at the prescribed necessary value H vac =0 of the GR for the energy of the Universe while the system is found regular for H vac >0 and chaotic for H vac <0 with respect to its pure vacuum part. In the case of generalized scalar tensor theories within the Bianchi IX model we show using the ADM formalism and a conformal transformation that the energy of the dynamical system as compared to vacuum lies below the threshold thus the system is not exhibiting chaos and the conclusion still holds in the presence of ordinary matter as well. The suppression of chaos occurs in a similar way for stiff matter alone

  3. The transitions 4p-5s in Y VI, Zr VII, Nb VIII and Mo IX

    International Nuclear Information System (INIS)

    Chaghtai, M.S.Z.; Rahimullah, K.; Khatoon, S.

    1976-01-01

    With the help of the spectra recorded in the Physics Department of Lund University, Y VI, Zr VII, Nb VIII and Mo IX are freshly analysed. The five 4s 2 4p 4 ground levels and the ten 4s 2 4p 3 5s levels of previous analyses are confirmed in the first three spectra, except for revising in Y VI the 4p 4 1 S 0 and 4p 3 5s( 4 Ssub(3/2)) 2 levels and interchanging 5s( 2 Dsub(3/2)) 1 with 5s( 2 Dsub(3/2)) 2 . All level values are improved due to the new measurements. A new analysis of Mo IX establishing all the 4p 4 and 4p 3 5s levels is being reported. (Auth.)

  4. Geografías urbanas en la era del neoliberalismo. Una conceptualización de la resistencia local a través de la participación y la ciudadanía urbana

    Directory of Open Access Journals (Sweden)

    Michael Janoschka

    2012-02-01

    Full Text Available Las discusiones relacionadas con la (inseguridad urbana, su consiguiente traducción política en un gobierno de la seguridad y la edificación de elementos urbanísticos defensivos han experimentado un auge espectacular a nivel mundial. En este artículo se interpretan las transformaciones urbanas (defensivas, estimuladas por un discurso dominante que está centrado en el miedo y la inseguridad, como una expresión del capitalismo global y de la difusión de políticas neoliberales. A partir de un análisis de los impulsos de mercado originado por un neoliberalismo multicolor, encubierto y camaleónico, se plantea la cuestión de cómo la necesaria reconquista urbana y la resistencia local se puede pensar de forma conceptual. En este sentido, se dará un paso más allá de la disputa urbana acerca de la gentrificación y el redescubrimiento urbano exclusivista que se dirigen a atraer a las clases pudientes a los espacios céntricos reacomodados y segurizados. Se defiende la tesis de que, a nivel local, es urgente promover una re-apropiación urbana ‘desde abajo’ que implica a los ciudadanos. Por ello se discuten las posibilidades de pensar la participación como una práctica de ciudadanía urbana y activa que se funda en la idea de construir verdaderos espacios de ciudadanía.

  5. Comparison of protoporphyrin IX content and related gene expression in the tissues of chickens laying brown-shelled eggs.

    Science.gov (United States)

    Li, Guangqi; Chen, Sirui; Duan, Zhongyi; Qu, Lujiang; Xu, Guiyun; Yang, Ning

    2013-12-01

    Protoporphyrin IX (PpIX), an immediate precursor of heme, is the main pigment resulting in the brown coloration of eggshell. The brownness and uniformity of the eggshell are important marketing considerations. In this study, 9 chickens laying darker brown shelled eggs and 9 chickens laying lighter brown shelled eggs were selected from 464 individually caged layers in a Rhode Island Red pureline. The PpIX contents were measured with a Microplate Reader at the wavelength of 412 nm and were compared in different tissues of the 2 groups. Although no significant difference in serum, bile, and excreta was found between the 2 groups, PpIX content in the shell gland and eggshell of the darker group was higher than in those of the lighter group, suggesting that PpIX was synthesized in the shell gland. We further determined the expression levels of 8 genes encoding enzymes involved in the heme synthesis and transport in the liver and shell gland at 6 h postoviposition by quantitative PCR. The results showed that expression of aminolevulinic acid synthase-1 (ALAS1) was higher in the liver of hens laying darker brown shelled eggs, whereas in the shell gland the expression levels of ALAS1, coproporphyrinogen oxidase (CPOX), ATP-binding cassette family members ABCB7 and ABCG2, and receptor for feline leukemia virus, subgroup C (FLVCR) were significantly higher in the hens laying darker brown shelled eggs. Our results demonstrated that hens laying darker brown shelled eggs could deposit more PpIX onto the eggshell and the brownness of the eggshell was dependent on the total quantity of PpIX in the eggshell. More heme was synthesized in the liver and shell gland of hens laying darker brown shelled eggs than those of hens laying lighter brown shelled eggs. High expression level of ABCG2 might facilitate the accumulation of PpIX in the shell gland.

  6. PROFIL PERTANYAAN SISWA TUNANETRA KELAS IX SMPLB YKAB SURAKARTA DALAM PEMBELAJARAN MATEMATIKA

    OpenAIRE

    Siti Khoiriyah

    2015-01-01

    Abstract Thinking can be drilled to the student by developing question skill during teaching process. Personal life quality is determined from question quality; the more qualified a question the more success a person in life. Therefore, this study analyzed the students question to find out the students question quality. The subject of this study is IX class of SMPLB YKAB students Surakarta. The data was found by observation with handy cam. The data analysis was conducted through data reductio...

  7. Puzzle of the particles and the universe. The inner life of the elementary particles IX d

    International Nuclear Information System (INIS)

    Geitner, Uwe W.

    2013-01-01

    The series The Inner Life of the Elementary Particles attempts to develop the elementary particles along of a genealogical tree, which begins before the ''big bang''. The simple presentation without mathematics opens also for the interested layman a plastic understanding. Volume IX discusses the known puzzles of particle physics and cosmology and offers for many of them explanation models. Explanation approaches are among others the ''DNA'' of the elementary particles and the interpretation of the quanta and the spin.

  8. Bianchi Type-IX viscous fluid cosmological model in general relativity

    Indian Academy of Sciences (India)

    the de-Sitter universe, the Taub-NUT solutions etc. are of Bianchi Type-IX space- times. In these models, neutrino viscosity does not guarantee isotropy at the present ..... The model (2.11) starts with a big-bang at T = 0 where α > 0 and m < 2, and the expansion in the model decreases as time increases. The expansion in the ...

  9. O Estatuto da Cidade e a democratização das políticas urbanas no Brasil

    OpenAIRE

    Avritzer, Leonardo

    2013-01-01

    O Brasil tem passado por um fortíssimo movimento de democratização do acesso a terra urbana e de regulamentação do uso da mesma. A origem destes processos está na organização do movimento pela reforma urbana nos anos 80 e sua atuação com êxito na Assembléia Nacional Constituinte. Neste artigo, iremos em primeiro lugar discutir a emergência e as principais características do movimento da reforma urbana no Brasil. Analisamos em detalhe como a relação entre as associações da sociedade civil e os...

  10. Delincuencia urbana y victimización de las víctimas/Urban delinquency and victimization of victims

    Directory of Open Access Journals (Sweden)

    Raúl Zaffaroni

    2012-08-01

    Full Text Available La población mundial tiende a concentrarse en ciudades y; por ende, la criminalidad también lo hace. El fenómeno de la delincuencia urbana es proyectado a la población a través de la comunicación masiva, que construye una realidad subjetiva, de la delincuencia urbana (proyección mediática del hecho. La respuesta política está condicionada por la proyección mediática y no al hecho mismo de la delincuencia urbana. Algunas víctimas producto de ese fenómeno, son manipuladas por los medios de comunicación, con fines políticos.

  11. YOUNG STELLAR POPULATIONS IN MYStIX STAR-FORMING REGIONS: CANDIDATE PROTOSTARS

    Energy Technology Data Exchange (ETDEWEB)

    Romine, Gregory; Feigelson, Eric D.; Getman, Konstantin V. [Department of Astronomy and Astrophysics, Pennsylvania State University, 525 Davey Lab, University Park, PA 16802 (United States); Kuhn, Michael A. [Millennium Institute of Astrophysics, Camino El Observatorio 1515, Las Condes, Santiago (Chile); Povich, Matthew S., E-mail: edf@astro.psu.edu [Department of Physics and Astronomy, California State Polytechnic University, 3801 West Temple Ave., Pomona, CA 91768 (United States)

    2016-12-20

    The Massive Young Star-Forming Complex in Infrared and X-ray (MYStIX) project provides a new census on stellar members of massive star-forming regions within 4 kpc. Here the MYStIX Infrared Excess catalog and Chandra -based X-ray photometric catalogs are mined to obtain high-quality samples of Class I protostars using criteria designed to reduce extragalactic and Galactic field star contamination. A total of 1109 MYStIX Candidate Protostars (MCPs) are found in 14 star-forming regions. Most are selected from protoplanetary disk infrared excess emission, but 20% are found from their ultrahard X-ray spectra from heavily absorbed magnetospheric flare emission. Two-thirds of the MCP sample is newly reported here. The resulting samples are strongly spatially associated with molecular cores and filaments on Herschel far-infrared maps. This spatial agreement and other evidence indicate that the MCP sample has high reliability with relatively few “false positives” from contaminating populations. But the limited sensitivity and sparse overlap among the infrared and X-ray subsamples indicate that the sample is very incomplete with many “false negatives.” Maps, tables, and source descriptions are provided to guide further study of star formation in these regions. In particular, the nature of ultrahard X-ray protostellar candidates without known infrared counterparts needs to be elucidated.

  12. Aplikasi Peta Kendali p sebagai Pengendalian Kualitas Karet di PTPN IX Batujamus/Kerjoarum

    Directory of Open Access Journals (Sweden)

    Isti Khomah

    2016-03-01

    Full Text Available The increasing of global rubber consumption is an opportunity as well as a challenge for Indonesian rubber produsers to increase the quantity and the quality of production. Faced the competition between countries, the quality of rubber products should be enhanced adapted to consumer demand. This study aims to determine whether the quality of the rubber produced in PTPN IX (Persero Garden Batujamus/Kerjoarum still within the control or not. This study uses time series data, in the form of rubber production data during March 2012 - February 201, that were analyzed descriptively using Control p Chart Analysis. Control p Chart describe the proportion of production damage that can be tolerated as a tool for statistical Control p Chart Application as Quality Control Tools for Rubber Production in PTPN IX Batujamus/Kerjoarum process control. This study shows that the quality of the rubber produced by PTPN IX (Persero Garden Batujamus/ Kerjoarum is out of the control. The Control p Chart proves that there are still many points that are outside the production control line. The production domination of the third RSS type (RSS 3 cause this problem, so that the profit and the efficiency of the company can be increased if the RSS 3 product can be controlled and be changed with the production of RSS 1.

  13. Comparison between two portable devices for widefield PpIX fluorescence during cervical intraepithelial neoplasia treatment

    Science.gov (United States)

    Carbinatto, Fernanda M.; Inada, Natalia Mayumi; Lombardi, Welington; Cossetin, Natália Fernandez; Varoto, Cinthia; Kurachi, Cristina; Bagnato, Vanderlei Salvador

    2015-06-01

    The use of portable electronic devices, in particular mobile phones such as smartphones is increasing not only for all known applications, but also for diagnosis of diseases and monitoring treatments like topical Photodynamic Therapy. The aim of the study is to evaluate the production of the photosensitizer Protoporphyrin IX (PpIX) after topical application of a cream containing methyl aminolevulinate (MAL) in the cervix with diagnosis of Cervical Intraepithelial Neoplasia (CIN) through the fluorescence images captured after one and three hours and compare the images using two devices (a Sony Xperia® mobile and an Apple Ipod®. Was observed an increasing fluorescence intensity of the cervix three hours after cream application, in both portable electronic devices. However, because was used a specific program for the treatment of images using the Ipod® device, these images presented better resolution than observed by the Sony cell phone without a specific program. One hour after cream application presented a more selective fluorescence than the group of three hours. In conclusion, the use of portable devices to obtain images of PpIX fluorescence shown to be an effective tool and is necessary the improvement of programs for achievement of better results.

  14. YOUNG STELLAR POPULATIONS IN MYStIX STAR-FORMING REGIONS: CANDIDATE PROTOSTARS

    International Nuclear Information System (INIS)

    Romine, Gregory; Feigelson, Eric D.; Getman, Konstantin V.; Kuhn, Michael A.; Povich, Matthew S.

    2016-01-01

    The Massive Young Star-Forming Complex in Infrared and X-ray (MYStIX) project provides a new census on stellar members of massive star-forming regions within 4 kpc. Here the MYStIX Infrared Excess catalog and Chandra -based X-ray photometric catalogs are mined to obtain high-quality samples of Class I protostars using criteria designed to reduce extragalactic and Galactic field star contamination. A total of 1109 MYStIX Candidate Protostars (MCPs) are found in 14 star-forming regions. Most are selected from protoplanetary disk infrared excess emission, but 20% are found from their ultrahard X-ray spectra from heavily absorbed magnetospheric flare emission. Two-thirds of the MCP sample is newly reported here. The resulting samples are strongly spatially associated with molecular cores and filaments on Herschel far-infrared maps. This spatial agreement and other evidence indicate that the MCP sample has high reliability with relatively few “false positives” from contaminating populations. But the limited sensitivity and sparse overlap among the infrared and X-ray subsamples indicate that the sample is very incomplete with many “false negatives.” Maps, tables, and source descriptions are provided to guide further study of star formation in these regions. In particular, the nature of ultrahard X-ray protostellar candidates without known infrared counterparts needs to be elucidated.

  15. Analyses of the Sn IX-Sn XII spectra in the EUV region

    International Nuclear Information System (INIS)

    Churilov, S S; Ryabtsev, A N

    2006-01-01

    The Sn IX-Sn XII spectra excited in a vacuum spark have been analysed in the 130-160 A wavelength region. The analysis was based on the energy parameter extrapolation in the isonuclear Sn VI-VIII and Sn XIII-XIV sequence. 266 spectral lines belonging to the 4d m -(4d m-1 4f+4p 5 4d m+1 ) (m=6-3) transition arrays were classified in the Sn IX-Sn XII spectra for the first time. All 18 level energies of the 4d 3 configuration and 39 level energies of the strongly interacting 4d 2 4f and 4p 5 4d 4 configurations were established in the Sn XII spectrum. The energy differences between the majority of the 4d m levels and about 40 levels of the 4d m-1 4f+4p 5 4d m+1 configurations were determined in each of the Sn IX, Sn X and Sn XI spectra (m=6-4). As a result, all intense lines were classified in the 130-140 A region relevant to the extreme ultraviolet (EUV) lithography. It was shown that the most of the intense lines in the 2% bandwidth at 135 A belong to the transitions in the Sn XI-Sn XIII spectra

  16. Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs

    Directory of Open Access Journals (Sweden)

    Tomas Eija

    2004-10-01

    Full Text Available Abstract Background Carbonic anhydrase (CA classically catalyses the reversible hydration of dissolved CO2 to form bicarbonate ions and protons. The twelve active CA isozymes are thought to regulate a variety of cellular functions including several processes in the reproductive systems. Methods The present study was designed to investigate the expression of transmembrane CAs, CA IX and XII, in the mouse uterus, ovary and placenta. The expression of CA IX and XII was examined by immunoperoxidase staining method and western blotting. CA II and XIII served as positive controls since they are known to be present in the mouse reproductive tract. Results The data of our study indicated that CA XII is expressed in the mouse endometrium. Only very faint signal was observed in the corpus luteum of the ovary and the placenta remained mainly negative. CA IX showed weak reaction in the endometrial epithelium, while it was completely absent in the ovary and placenta. Conclusion The conservation of CA XII expression in both mouse and human endometrium suggests a role for this isozyme in reproductive physiology.

  17. High-resolution Laboratory Measurements of Coronal Lines near the Fe IX Line at 171 Å

    Science.gov (United States)

    Beiersdorfer, Peter; Träbert, Elmar

    2018-02-01

    We present high-resolution laboratory measurements in the spectral region between 165 and 175 Å that focus on the emission from various ions of C, O, F, Ne, S, Ar, Fe, and Ni. This wavelength region is centered on the λ171 Fe IX channel of the Atmospheric Imaging Assembly on the Solar Dynamics Observatory, and we place special emphasis on the weaker emission lines of Fe IX predicted in this region. In general, our measurements show a multitude of weak lines missing in the current databases, where the emission lines of Ni are probably most in need of further identification and reclassification. We also find that the wavelengths of some of the known lines need updating. Using the multi-reference Møller–Plesset method for wavelength predictions and collisional-radiative modeling of the line intensities, we have made tentative assignments of more than a dozen lines to the spectrum of Fe IX, some of which have formerly been identified as Fe VII, Fe XIV, or Fe XVI lines. Several Fe features remain unassigned, although they appear to be either Fe VII or Fe X lines. Further work will be needed to complete and correct the spectral line lists in this wavelength region.

  18. In vivo wide-field multispectral dosimeter for use in ALA-PpIX based photodynamic therapy of skin

    Science.gov (United States)

    LaRochelle, Ethan P. M.; Davis, Scott C.; de Souza, Ana Luiza Ribeiro; Pogue, Brian W.

    2017-02-01

    Photodynamic therapy (PDT) for Actinic Kertoses (AK) using aminoluvelinic acid (ALA) is an FDA-approved treatment, which is generally effective, yet response rates vary. The origin of the variability is not well characterized, but may be related to inter-patient variability in the production of protoporphyrin IX (PpIX). While fiber-based point probe systems provide a method for measuring PpIX production, these measurements have demonstrated large spatial and inter-operator variability. Thus, in an effort to improve patient-specific dosimetry and treatment it is important to develop a robust system that accounts for spatial variability and reduces the chance of operator errors. To address this need, a wide-field multispectral imaging system was developed that is capable of quantifying maps of PpIX in both liquid phantoms and in vivo experiments, focusing on high sensitivity light signals. The system uses both red and blue excitation to elicit a fluorescent response at varying skin depths. A ten-position filter wheel with bandpass filters ranging from 635nm to 710nm are used to capture images along the emission band. A linear least-square spectral fitting algorithm provides the ability to decouple background autofluorescence from PpIX fluorescence, which has improved the system sensitivity by an order of magnitude, detecting nanomolar PpIX concentrations in liquid phantoms in the presence of 2% whole blood and 2% intralipid.

  19. Optical-sectioning microscopy of protoporphyrin IX fluorescence in human gliomas: standardization and quantitative comparison with histology

    Science.gov (United States)

    Wei, Linpeng; Chen, Ye; Yin, Chengbo; Borwege, Sabine; Sanai, Nader; Liu, Jonathan T. C.

    2017-04-01

    Systemic delivery of 5-aminolevulinic acid leads to enhanced fluorescence image contrast in many tumors due to the increased accumulation of protoporphyrin IX (PpIX), a fluorescent porphyrin that is associated with tumor burden and proliferation. The value of PpIX-guided resection of malignant gliomas has been demonstrated in prospective randomized clinical studies in which a twofold greater extent of resection and improved progression-free survival have been observed. In low-grade gliomas and at the diffuse infiltrative margins of all gliomas, PpIX fluorescence is often too weak to be detected with current low-resolution surgical microscopes that are used in operating rooms. However, it has been demonstrated that high-resolution optical-sectioning microscopes are capable of detecting the sparse and punctate accumulations of PpIX that are undetectable via conventional low-power surgical fluorescence microscopes. To standardize the performance of high-resolution optical-sectioning devices for future clinical use, we have developed an imaging phantom and methods to ensure that the imaging of PpIX-expressing brain tissues can be performed reproducibly. Ex vivo imaging studies with a dual-axis confocal microscope demonstrate that these methods enable the acquisition of images from unsectioned human brain tissues that quantitatively and consistently correlate with images of histologically processed tissue sections.

  20. Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis

    Science.gov (United States)

    Kanick, Stephen Chad; Davis, Scott C.; Zhao, Yan; Hasan, Tayyaba; Maytin, Edward V.; Pogue, Brian W.; Chapman, M. Shane

    2014-07-01

    Dosimetry for aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy of actinic keratosis was examined with an optimized fluorescence dosimeter to measure PpIX during treatment. While insufficient PpIX generation may be an indicator of incomplete response, there exists no standardized method to quantitate PpIX production at depths in the skin during clinical treatments. In this study, a spectrometer-based point probe dosimeter system was used to sample PpIX fluorescence from superficial (blue wavelength excitation) and deeper (red wavelength excitation) tissue layers. Broadband white light spectroscopy (WLS) was used to monitor aspects of vascular physiology and inform a correction of fluorescence for the background optical properties. Measurements in tissue phantoms showed accurate recovery of blood volume fraction and reduced scattering coefficient from WLS, and a linear response of PpIX fluorescence versus concentration down to 1.95 and 250 nM for blue and red excitations, respectively. A pilot clinical study of 19 patients receiving 1-h ALA incubation before treatment showed high intrinsic variance in PpIX fluorescence with a standard deviation/mean ratio of >0.9. PpIX fluorescence was significantly higher in patients reporting higher pain levels on a visual analog scale. These pilot data suggest that patient-specific PpIX quantitation may predict outcome response.

  1. O direito à cidade e as agendas urbanas internacionais: uma análise documental

    Directory of Open Access Journals (Sweden)

    Elisabete Agrela de Andrade

    Full Text Available Resumo Considerando as problemáticas sociais, econômicas e demográficas, viver na cidade implica condições inadequadas de moradia, exclusão social, iniquidades e outros agravos à população. Simultaneamente, a cidade também é cenário das produções culturais, sociais e afetivas. Cresceu, então, a necessidade de refletir sobre o direito à cidade e a relação com a promoção da saúde de seus habitantes. Para contribuir, agendas urbanas foram construídas pensando nesta ambiguidade da cidade. Objetiva-se analisar quatro destas agendas à luz do referencial da Promoção da Saúde. Foi realizada uma pesquisa documental de abordagem qualitativa de agendas urbanas propostas por organismos internacionais e adotadas em contexto brasileiro: Cidades Saudáveis, Cidades Sustentáveis, Cidades Inteligentes e Cidades Educadoras. Os resultados mostram que há empenho, em maior ou menor grau, por parte das agendas analisadas, em assumir a participação social, a intersetorialidade e o território como fundamentais no enfrentamento das exclusões e iniquidades, mas há falta de debates aprofundados sobre cada um destes conceitos. Conclui-se que as agendas urbanas podem ser importante aporte na consolidação do direito à cidade, desde que haja a compreensão crítica dos conceitos que as sustentam.

  2. USO DO SOLO E TEMPERATURA SUPERFICIAL EM ÁREA URBANA

    Directory of Open Access Journals (Sweden)

    Ivan Júlio Apolônio Callejas

    2011-01-01

    Full Text Available Este estudio evalua la isla de calor de la area urbana y el relación espacio-temporal entre el uso del suelo y la temperatura superfi cial (Ts en lá ciudad de Várzea Grande, quien junto a Cuiabá (capital del estado forman uno de los conglomerados más grandes de la zona Centro-Oeste de Brasil, donde la urbanización ha sido intensa desde los años 60. Se utilizó imágenes multiespectrales de satélite Landsat-5 TM para preparar mapas del uso y ocupación del suelo y temperaturas de la superfi cie (Ts y se detectó la presencia de isla de calor de la superfi cie urbana en la ciudad de Várzea Grande. Los resultados muestran que los mayores valores medios de Ts se encuentran en los suelos expuestos (2.0°C y en las zonas urbanizadas (2.13°C. Sin embargo, no podemos decir que la isla de calor urbano es un fenómeno consolidado en la región. A fi n de reducir las Ts en zonas urbanas de la ciudad, se recomienda la revisión de las tasas de urbanización y las acciones de promoción destinadas a preservar la vegetación restante y desplegar nuevas zonas verdes en lugares estratégicos de la ciudad, y utilizar materiales alternativos que reducen el almacenamiento energía.

  3. La città sotterranea e il suo ruolo nella mobilità urbana

    Directory of Open Access Journals (Sweden)

    Giuseppe Mazzeo

    2008-12-01

    Full Text Available La città sotterranea è un elemento fondamentale nella struttura urbana. Soprattutto nelle grandi città essa assume connotazioni rilevanti nella pianificazione urbana in considerazione del fatto che rappresenta una risorsa e il suo impiego può incidere significativamente sull’efficienza del sistema urbano. Alcune città, a causa soprattutto della rigidità del clima, hanno progettato città sotterranee di grande complessità funzionale; esempi significativi sono Montreal, Toronto e altre città del Nord America. In Europa occidentale le realizzazioni associabili al concetto di città sotterranea sono più limitate e sono relative soprattutto alla realizzazione di infrastrutture per la mobilità urbana, come le reti metropolitane, i passanti ferroviari, i tunnel stradali e i parcheggi sotterranei. La funzione primaria di questi spazi è la riduzione e lo spostamento dalla superficie di quote di traffico e la trasformazione di ampie parti della città in aree verdi o in aree a maggiore qualità ambientale. In ogni modo è possibile sostenere che l’uso degli spazi sotterranei è ormai entrato a far parte della vita delle città moderne. L’articolo analizza alcuni dei fattori principali nella costruzione di questi spazi urbani; i costi e i benefici dell’uso di spazi sotterranei sono messi in relazione con gli aspetti psicologici e con la costruzione di modelli per la previsione dei percorsi degli utenti. La seconda parte dell’articolo mostra alcuni casi studio evidenziando le diverse necessità che hanno spinto e hanno guidato verso la scelta degli spazi sotterranei; una analisi più dettagliata è svolta sul caso di Montreal, che può essere considerato archetipo della citta sotterranea.

  4. Desenho de paisagem urbana: as cidades médias do interior central paulista

    Directory of Open Access Journals (Sweden)

    Paula da Cruz Landim

    2002-12-01

    Full Text Available Este trabalho focaliza a homogeneidade da paisagem urbana das cidades de porte médio do interior do estado de São Paulo do ponto de vista de seus determinantes paisagísticos. A origem socioeconômica das cidades determina, em um primeiro momento, sua configuração, a qual, esgotado o estímulo inicial, passa a incorporar as imagens formais das grandes cidades. Estas imagens estão claramente representadas de um modo específico na paisagem urbana dessas cidades, evidenciando os reflexos formais e funcionais das paisagens dos grandes centros, e na geração de valores estéticos e de uso do espaço relacionados aos aspectos formais e visuais que se fazem presentes em suas paisagens. A legislação que define os padrões de ocupação urbana, os quais por sua vez definem a configuração física da paisagem, trabalha basicamente o espaço físico-territorial, alienando-se dos demais componentes da problemática urbana, e, desta forma, as cidades se homogeneízam. Ou seja, gera um discurso urbanístico pobre e o que se faz é generalista. A paisagem da cidade média paulista é então homogênea como conseqüência desta forma de ocupação homogênea. Como contraposição à paisagem homogênea, algumas condições ambientais e paisagísticas locais, como a presença de um rio ou de uma topografia acidentada, servem de início como determinantes para projetos urbanísticos/paisagísticos diferenciados e característicos para cada cidade, mas no momento seguinte os elementos da" moda" entram na composição da paisagem, descaracterizando o padrão diferenciado inicial.

  5. ¿Síntomas o conflictos? Políticas e investigaciones urbanas

    OpenAIRE

    García Canclini, Néstor

    2008-01-01

    El artículo trata las relaciones entre cultura y ciudad en los últimos 15 años, así como la reestructuración de los campos culturales -el nuevo papel de las empresas privadas y el debilitamiento del Estado en las políticas culturales-, las redes audiovisuales como actores claves de la información y el entretenimiento y la desintegración urbana y los conflictos socioculturales. The article treats the relations between culture and city in the last 15 years, as well as the restructuring of th...

  6. Las autopistas urbanas concesionadas: Una nueva forma de segregación

    OpenAIRE

    Greene,Margarita; Mora,Rodrigo

    2005-01-01

    Si es que existiera el modelo de ciudad automovilística, sin duda sería el referente que ha determinado las intervenciones urbanas en Santiago durante los últimos treinta años: aparte del caso relativamente aislado del ferrocarril subterráneo, son incontables los kilómetros entregados al tráfico vehicular. Las concesiones viales inauguran la formalización de un sistema de clases dentro del parque automotriz; un sistema que lamentablemente informará la manera en que entendemos y experimentamos...

  7. A antropologia urbana e os desafios da metrópole

    Directory of Open Access Journals (Sweden)

    José Guilherme Cantor Magnani

    2003-04-01

    Full Text Available O texto analisa a situação da disciplina antropologia urbana no campo das ciências sociais e sua contribuição para o estudo e a compreensão do fenômeno urbano, principalmente no caso das grandes metrópoles contemporâneas. O eixo da argumentação é o de que, para realizar essa tarefa, a antropologia urbana tem à sua disposição o método etnográfico, porém o desafio é aplicar essa abordagem sem cair na "tentação da aldeia", isto é, a de buscar na heterogênea realidade das grandes cidades as condições da aldeia - pequenos grupos, contextos limitados - supostamente identificadas com o enfoque etnográfico. Vários exemplos de pesquisas recentes sobre a cidade de São Paulo, realizados no Núcleo de Antropologia Urbana (NAU e no Departamento de Antropologia da USP são apresentados para mostrar as potencialidades da aplicação de conceitos, técnicas e métodos desenvolvidos na antropologia e, em particular, na antropologia urbana, para o estudo de formas de sociabilidade e práticas culturais na escala da metrópole.State of the art of urban anthropology as a subject in the field of social sciences and its contribution to the study and understanding of the urban phenomenon, mainly in the case of great contemporary metropolises. Urban anthropology has at its disposal the ethnographic method but the challenge is to apply this approach without falling into the ' village temptation', i.e., that of looking at the heterogeneous reality of the big cities for the village conditions - small groups, limited contexts - which are supposedly identified by the ethnographic approach. Various examples of recent researches on the city of São Paulo, undertaken in the Urban Anthropology Nucleus (NAU and in the Department of Anthropology of USP, are presented to show the potentiality of the application of concepts, techniques and methods developed in anthropology, and in particular, in urban anthropology, for the study of forms of sociability

  8. La desaceleración metropolitana y su reflejo en la realidad urbana del occidente europeo

    OpenAIRE

    Muguruza Cañas, Carmen; Santos Preciado, José Miguel

    1990-01-01

    La literatura urbanística de los años sesenta nos había acostumbrado a establecer una relación directa entre desarrollo económico y concentración urbana. Desde el siglo pasado, las tendencias inherentes al proceso de la revolución industrial confirmaban la progresiva concentración de la población en ciudades millonarias, siguiendo el modelo territorial metropolitano. Los flujos migratorios del campo a la ciudad eran la consecuencia lógica de la transformación del sistema productivo de un país...

  9. Altas llantas : Una historia de la recepción de zapatillas urbanas

    OpenAIRE

    Dalponte, Sofía

    2012-01-01

    La construcción social del discurso de la zapatilla urbana se explica por la vinculación inmanente del objeto con su contexto. El signo se vincula con otros que lo rodean y lo atraviesan, tanto en la producción como en el reconocimiento, siguiendo un modelo de semiosis social. Los diversos modos de apropiación o individuación de sentido que vivencian los usuarios manifiestan la red de significantes que subyace a este producto en la práctica social. (Párrafo extraído del texto a mod...

  10. Estado del arte y perspectivas de futuro de la movilidad personal urbana

    OpenAIRE

    Rey Garrido, Jorge

    2014-01-01

    El presente Trabajo de Fin de Grado se ha desarrollado con el objetivo de buscar soluciones reales a los principales problemas ocasionados por el automóvil en su vertiente urbana, a través de la revisión de la literatura disponible. Para ello, en primer lugar se ha analizado cuáles son estos problemas, tanto a nivel medioambiental y energético como a nivel de desarrollo de la vida en las ciudades. Entre los encontrados destacan la contaminación atmosférica, la falta de espacio operativo en...

  11. Agricultura urbana: un aporte a la rehabilitación integral

    OpenAIRE

    Moran Alonso, Nerea

    2010-01-01

    El artículo repasa los antecedentes históricos de la agricultura urbana, práctica a la cual en determinados momentos han recurrido diferentes Administra - ciones. Estas prácticas son un ejemplo de cómo actuar en una situación de crisis y de la potencialidad social que tiene la producción de alimentos en un contexto urbano. En países del Sur, han adquirido importancia como estrategia de desarrollo e incluido programas liderados por organismos internacionales. Los huertos urbanos, un modo de in...

  12. Comercio y movilizaciones urbanas al momento de la metropolización

    OpenAIRE

    Lulle, Thierry

    2014-01-01

    El objetivo de este seminario era aportar algunos elementos de reflexión sobre la actividad comercial contemporánea al apasionado debate que se desarrolla actualmente en México, y también en numerosas ciudades latinoamericanas, al rededor de la llamada «invasión» del espacio público por los comerciantes ambulantes. Dicho debate público es dominado frecuentemente por el discurso de las clases medias urbanas que rechazan radicalmente este fenómeno aun cuando sus prácticas de consumo son mucho m...

  13. Jundiaí (SP: transformações recentes na paisagem urbana

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    Adriana Fornari Del Monte Fanelli

    2014-06-01

    Full Text Available O objetivo deste trabalho é analisar aspectos condicionantes das transformações e as tipologias presentes na paisagem urbana de Jundiaí na região situada às margens das rodovias Dom Gabriel P. B. Couto e João Cereser, nas proximidades da serra do Japi. A partir da conceituação de Magnoli (1982 de espaços livres, e através da análise de informações de diversas naturezas, como legislações urbanísticas, fotos aéreas e visitas in loco, pode-se afirmar que Jundiaí, cidade-polo do Aglomerado Urbano de Jundiaí (AUJ, caracteriza-se pela presença de grandes áreas de preservação ambiental, como a serra do Japi, e áreas de conservação de mananciais, que impedem a expansão urbana para os vetores sul ou leste, favorecendo o crescimento da forma urbana no sentido noroeste e oeste. Devido à sua localização, num espaço intersticial entre as Regiões Metropolitanas de São Paulo, Campinas e o Aglomerado Urbano de Sorocaba (AUS, a cidade convive com diversas influências socioeconômicas e espaciais decorrentes do processo de metropolização típico da macrometrópole paulista. Assim, as áreas de preservação ambiental, as presenças de espaços livres não urbanizados de grandes proporções e a sinergia de Jundiaí com a rede de cidades dos Aglomerados Urbanos tornaram-se os principais agentes transformadores da paisagem urbana deste território.

  14. Estudio sobre Logística urbana en el casco antiguo de Cartagena

    OpenAIRE

    Muñoz Heredia, Jorge

    2014-01-01

    El objetivo principal del proyecto es el análisis de la logística urbana y posibles problemas existentes respecto al transporte del Casco Antiguo de Cartagena. La metodología a emplear será parecida a la propuesta Taniguchi 1999, cuyos pasos a seguir son: La descripción de los problemas existentes en la ciudad respecto al transporte de mercancías, en éste caso se ha cogido como referencia, el centro histórico de Cartagena, que hemos delimitados tres puntos claves: 1) Bar Sol, intersección ...

  15. Urban governance in Istanbul Governança urbana em Istambul

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    Nil Uzun

    2010-01-01

    Full Text Available Urban governance has been an important issue since the 1980s, as have the effects of globalisation on urban policies. Although no consensus exists on a definition of governance, it is possible to state that it expresses a shift in the roles of formal government structure, and especially the change in the sharing of responsibilities between the public, private, voluntary, and household spheres. Turkey has also been experiencing the effects of globalisation, and there is an ongoing restructuring process within which government structures are moving toward governance. The goal of this paper is to present a critical evaluation of urban governance. This will be done with the focus on whether the concept of urban governance can explain the urban management model in countries on the periphery. The case of Istanbul is used as an example for this discussion.A governança urbana e os efeitos da globalização têm assumido uma importância crescente desde a década de 80 do século xx nas políticas urbanas. Embora não exista um consenso quanto à definição de governança, é possível afirmar que esta representa uma alteração nas estruturas formais de governo, e especialmente uma mudança na divisão de responsabilidades entre as esferas pública, privada, voluntária e doméstica. Os efeitos da globalização também se fizeram sentir na Turquia, onde se assiste a um processo de alteração das estruturas de governo no sentido das práticas de governança. Este texto pretende avaliar de forma crítica este processo, analisando se o conceito de governança urbana será capaz de explicar modelos de gestão urbana em países da periferia. O caso de Istambul será usado como exemplo para tal discussão.

  16. Approcci innovativi alla mobilità urbana: il caso di Istanbul

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    Cecilia Scoppetta

    2010-02-01

    Full Text Available  L'attuale assetto dell'area metropolitana di Istanbul evidenzia con chiarezza il rapporto tra sistema della mobilità urbana ed espansione incontrollata del costruito. Gli strumenti di pianificazione utilizzati nel passato si sono rivelati inefficaci ed hanno prodotto una città in larga parte illegale che oggi appare ingovernabile. Tuttavia anche i nuovi strumenti del piano strategico e del progetto urbano sembrano mostrare i propri limiti. Una maggiore integrazione tra politiche urbane ancora troppo settoriali può contribuire alla definizione di approcci realmente innovativi.

  17. GESTÃO DA DRENAGEM URBANA NO BRASIL: DESAFIOS PARA A SUSTENTABILIDADE

    OpenAIRE

    Vladimir Caramori Borges de Souza

    2013-01-01

    Os sistemas de drenagem urbana no Brasil ainda seguem um padrão baseado apenas em eficiência hidráulica de condutos, apesar de já haver um reconhecimento de que este tipo de abordagem não resolve os problemas no longo prazo; é apenas uma ação pontual e que age sobre os efeitos. Desta forma, os sistemas de drenagem continuam sendo concebidos, dimensionados e projetados para falhar. Apesar de haver grande avanço acadêmico no desenvolvimento de técnicas e abordagens mais integradoras, com foco n...

  18. Estrategias para el abastecimiento de agua a comunidades marginadas y urbanas.

    OpenAIRE

    Juan Martínez, José

    2012-01-01

    Esta investigación tuvo como objetivo formular estrategias y escenarios para el abastecimiento de agua para consumo humano, uso doméstico y productivo, considerando las condiciones socioculturales, económicas y modos de producción; con el propósito de identificar tecnologías que atienden las demandas actuales y futuras en materia de agua en la entidad del DF y Estado de México. Se inició con el diseño de cinco escenarios de caso: casa rural marginada, urbana, residencia, mediana industria e i...

  19. Consciència de la higiène urbana en una Barcelona ofegada

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    el Haddad, Marie

    2017-01-01

    El Casc Antic de Barcelona va patir de sobrepoblació, congestió i diversos brots epidèmics fets que van augmentar la vigilància i preocupació per la higiene urbana. Un dels primers intents va començar quan Carles III i Carles IV van emetre reials decrets relatius a l'exhumació dels cementiris. El primer va prohibir de l'enterrament al costat de esglésies i hospitals i va imposar la conversió dels existents en places públiques, i el segon va permetre la construcció de cementiris extramurs llun...

  20. Energia e mobilidade urbana : uma proposta de ensino por investigação utilizando TICs

    OpenAIRE

    Guttmann, Gustavo; Barbosa Braga, Marco Antonio

    2017-01-01

    Este trabalho se propõe a contribuir para a construção de cenários mais favoráveis a utilização de TICs em sala de aula. Para isso foi proposta uma experiência em sala de aula no curso regular de Física para o Ensino Médio onde os alunos foram incentivados ao uso de seus dispositivos conectados à internet, durante a aula, principalmente smartphones. O projeto teve como tema a Mobilidade Urbana e buscou avaliar a construção de estratégias menos expositivas por parte do professor e mais ativa p...

  1. Revueltas: la otra globalización urbana / Riots: The other urban globalization

    OpenAIRE

    Bertho, Alain

    2012-01-01

    ResumenLa dimensión urbana de la globalización muestra de forma evidente las cuestiones que en la actualidad se juegan en el terreno de las identidades sociales, la representación política y el Estado. En ese sentido la ciudad global es realmente el espacio estratégico de nuestro tiempo. Los conflictos que se desarrollan en ella ya no tienen su raíz en las identidades colectivas anteriores y encuentran cada vez con más dificultad un espacio de representación política donde expresarse. En esas...

  2. Eliminaci??n de xenobi??ticos de aguas residuales urbanas mediante biorreactores de membrana sumergida

    OpenAIRE

    Gonz??lez P??rez, Daniel Mar??a

    2017-01-01

    El presente trabajo pretende valorar la eficacia de la tecnolog??a MBR en la eliminaci??n de xenobi??ticos de las aguas residuales urbanas bajo condiciones de elevado tiempo de retenci??n celular (SRT) y elevado tiempo de retenci??n hidr??ulica (HRT), y para el desarrollo del mismo se seleccionaron dos de los grupos de xenobi??ticos m??s importantes, los f??rmacos entre los considerados contaminantes emergentes y los hidrocarburos arom??ticos polic??clicos entre los contaminantes cl??sicos.

  3. Estudio del tratamiento anaerobio de aguas residuales urbanas en biorreactores de membranas

    OpenAIRE

    Giménez García, Juan Bautista

    2014-01-01

    Las aguas residuales urbanas (ARU) constituyen la fuente puntual de contaminantes más importante a escala global. Actualmente, un elevado porcentaje de las aguas residuales producidas a nivel mundial son vertidas al medio sin haber recibido ningún tipo de tratamiento, con consecuencias inmediatas, y en algunas ocasiones desastrosas, para la salud pública y la calidad del entorno natural. El tratamiento anaerobio está considerado como una de las alternativas más atractivas para el desarroll...

  4. Cidades sutis: dispersão urbana e da rede de saúde mental

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    Luis Artur Costa

    2013-01-01

    Full Text Available Este artigo pretende problematizar o percurso genealógico que possibilita o atual arranjo entre a cidade de Porto Alegre e sua assistência em saúde mental. Inicia com a cidade e seu Hospital Psiquiátrico São Pedro, constituídos a partir de uma lógica disciplinar que buscava subjetivar corpos e gestos adequados para o trabalho industrial e aos padrões de convivência da civilidade urbana moderna. Vemos então o surgimento de movimentos anômalos a esta geometria, espasmos descentralizantes que vão esboroando as antigas centralidades e seus lócus antes fechados. Através da breve genealogia dos movimentos que tomaram tais espaços, operamos a problematização das transformações nesta cidade e nas atuais práticas de assistência à saúde mental: por um lado, as novas microssegmentações privadas no espaço urbano contemporâneo minando a centralidade urbana da cidade com a dispersão da convivência e, por outro, a atual reforma psiquiátrica, com a descentralização da assistência.

  5. Pixações sob a ótica da arqueologia urbana

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    Rafael de Abreu Souza

    2015-06-01

    Full Text Available O texto tem como objetivo apresentar elementos para uma discussão sobre as pixações a partir de leituras da Arqueologia Urbana. Para tal, serão utilizadas pixações outrora pertencentes ao complexo fabril Cianê, situado na cidade de Sorocaba, São Paulo, conjunto edificado no final do século XIX, com utilização, enquanto fábrica têxtil, até os anos de 1970. Argumenta-se que os discursos que reafirmam o abandono do complexo fabril, após sua falência, passando por seu processo de tombamento e atual revitalização e restauro para abarcar um novo shopping no centro da cidade, pautam-se pelas relações de poder e patrimônio demasiado normativas e que segregam, ainda mais, grupos sociais cuja vivência coletiva se expressa a partir de práticas de ressignificação e reconstrução da paisagem urbana.

  6. La reinvención de lo público en la videocultura urbana

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    Néstor García Canclini

    2002-01-01

    Full Text Available ¿Se puede reconstruir lo público en una megalópolis donde lo privado invade todo, donde las reglas se reemplazan por el caos o por la simulación del control de quienes nos informan y vigilan? A partir de drásticos cambios producidos en la familia tradicional, la ciudad y el Estado-nación, se intenta replantear la definición de lo público en el nuevo tipo de experiencias urbanas establecidas por las megaciudades y los medios masivos de comunicación. Los medios electrónicos lo buscan construyendo imaginarios que articulan lo global y lo local así como en la visualidad publicitaria urbana, a través de la espectacularización de mercancías y servicios, incluidos aquellos a los que sólo acceden minorías. Esto lleva a evaluar en qué medida los medios cumplen una función pragmática o más bien una función simbólica y ritual.

  7. Lineamientos para el ordenamiento territorial de las periferias urbanas de la ciudad de México.

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    Jan Bazant

    2001-01-01

    Full Text Available Los programas de desarrollo urbano vigentes y sus normatividades han probado su ineficiencia como instrumentos de planeación urbana, pues a través de ellos se ha buscado regular la incesante expansión de las ciudades hacia sus periferias, a través de controles e intensidad de usos del suelo, otorgando similar criterio normativo tanto a zonas consolidadas como a aquellas en proceso de conversión rural a urbano, así como al medio ambiente inalterado. Este artículo plantea la necesidad de cambiar el enfoque "totalizador" de la planeación urbana actual -especialmente en su tratamiento de las periferias-, actuando únicamente sobre aquellas zonas con invaluable contenido ambiental para preservarlas intactas; sobre áreas que potencialmente pueden concentrar equipamiento y servicios para trasformarse en centros de barrio o subcentros de las extensas periferias, y sobre líneas de comunicación o arterias primarias que las estructuraran funcionalmente con la ciudad. Teniendo territorialmente asegurados los elementos ordenadores del desarrollo urbano, el resto de la periferia puede seguir expandiéndose como lo ha hecho hasta ahora, sin ningún control.

  8. Notas metodológicas: por uma etnografia urbana dos quadrinhos

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    Marina Cavalcante Vieira

    2013-02-01

    Full Text Available Como realizar uma etnografia urbana das cidades das histórias em quadrinhos e quais as potencialidades deste tipo de pesquisa? Este artigo tem como foco a discussão acerca do uso do método etnográfico para a análise de histórias em quadrinhos. As reflexões aqui expostas são atualizações do capítulo introdutório da pesquisa dissertativa Visões da Modernidade nas Histórias em Quadrinhos: Gotham e Metrópolis em finais de 1930 que teve como objetivo analisar as cidades do Super-Homem e Batman em seus contextos de criação. A questão metodológica mais imediata ao buscar uma análise etnográfica da representação urbana nos quadrinhos é a de como conceituar o objeto de estudo e o campo de pesquisa. A partir de um diálogo com outras abordagens não tradicionais – como a etnografia de arquivos históricos e a etnografia em espaços virtuais – é que se propõe o uso da etnografia para os quadrinhos. Este artigo demonstra a riqueza e potencial dos quadrinhos como objeto de pesquisa para as ciências sociais evidenciando novas possibilidades de abordagem metodológica.

  9. Riscos e vulnerabilidade socioambiental urbana: uma perspectiva a partir dos recursos hídricos

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    Francisco Mendonça

    2009-03-01

    Full Text Available A intensificação da urbanização na ultima etapa da modernidade gerou inúmeros problemas relacionados à qualidade e condições de vida humana nas cidades. No âmbito dos países não desenvolvidos estes problemas tomam maior magnitude que nos desenvolvidos, gerando consideráveis desafios à gestão socioambiental das áreas urbanas. O problema da qualidade da água e da gestão dos recursos hídricos aparece como um dos mais graves da sociedade contemporânea, notadamente em países como o Brasil, cujos rios urbanos encontram- se altamente degradados em sua grande maioria. A associação entre os perigos, os riscos e a vulnerabilidade socioambiental, quando enfocados na perspectiva da interação entre os recursos hídricos e a sociedade urbana, torna-se muito importante, constituindo-se no enfoque central do presente texto. Nesse contexto, a questão da escassez de água no ambiente urbano brasileiro é abordada e a problemática é explorada.

  10. POLÍTICAS URBANAS PARA EL DESARROLLO Y LA INNOVACIÓN EN LAS CIUDADES INTERMEDIAS

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    Henar Pascual Ruiz-Valdepeñas

    2008-01-01

    Full Text Available En los últimos años se asiste al fortalecimiento del papel de las ciudades intermedias al estimarsesu capacidad para lograr una mayor cohesión económica, social y territorial en Europa. Las políticas territoriales se orientan a reforzar sus ventajas competitivas y a potenciar la configuración y consolidación de redes de cooperación en las que las ciudades actúan como partes de un modelo policéntrico. La valoración de los impactos de los programas europeos en las ciudades y el análisis de las políticas y estrategias urbanas, ponen de relieve la naturaleza específica de los diversos niveles de intervención pública en el territorio y la multiplicidad de las interacciones que se generan entre ellos. En el nivel local de intervención, la planificación estratégica amplía el abanico de objetivos y actuaciones y aporta nuevos instrumentos que ponen el acento en el reforzamiento de los factores de competitividad urbana.

  11. Brincadeiras de rua, convivência urbana e ecologia dos saberes

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    ÁLAMO PIMENTEL

    2015-01-01

    Full Text Available Este artículo es el resultado de un estudio sobre la contribución de los juegos de la calle en la creación de procesos de convivencia urbana y en la diversificación de prácticas y saberes inherentes a las culturas populares que atraviesan lo cotidiano de las ciudades brasileñas. El texto se desarrolla a partir del análisis de documentos basados en los informes presentados por estudiantes de pedagogía de una institución de enseñanza superior del estado de Bahía. Los informes descriptivos analizados son el resultado de un proyecto didáctico de observación desde el punto de vista de los niños sobre la convivencia urbana. La base teórica del trabajo se inspira en las epistemologías del Sul según la propuesta de Boaventura de Sousa Santos (2008, sobre todo en lo referido a la comprensión de las ecologías de los saberes. A partir de los cuadros sinópticos presentados a lo largo del texto se expone una visión panorámica de los juegos de la calle en diferentes barrios de Salvador y sus implicaciones en la sustentabilidad de las culturas populares en los escenarios urbanos contemporáneos.

  12. Mundos aislados: segregación urbana y desigualdad en la ciudad de México

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    GONZALO A SARAVÍ

    2008-12-01

    Full Text Available De qué nos habla la segregación urbana en México y cuáles son sus implicaciones en este contexto en particular, son las dos preguntas centrales que guían el análisis desarrollado en este artículo. El argumento que responde a estas dos preguntas se estructura en torno a la hipótesis de una "coexistencia de mundos aislados". Para sustentar dicha hipótesis, el autor analiza teórica y empíricamente la relación entre las dimensiones objetiva y simbólica de la segregación urbana. El análisis se basa en datos secundarios y en información obtenida a partir de entrevistas semi-estructuradas con jóvenes residentes en colonias populares y estigmatizadas de la Ciudad de México.What does urban segregation mean in México and what are its implications for this particular context? This article poses these two questions. Our response is based on the hypothesis of the "co-existence of isolated worlds." In order to support and develop this hypothesis, the author analyses the relationship between the objective and symbolic dimensions of urban segregation. The analysis is based on secondary data and semi-structured interviews with young people from poor and stigmatized neighborhoods in México City.

  13. Elementos de reflexión sobre la resiliencia urbana: usos criticables y aportes potenciales

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    Pascale Metzger

    2013-01-01

    Full Text Available El propósito de este texto es discutir el concepto de resiliencia y buscar su interés heurístico para los análisis de vulnerabilidad urbana. El término resiliencia es omnipresente en la retórica de las declaraciones internacionales, de las políticas públicas y en las reflexiones académicas en el campo de los riesgos y desastres en ciudades. Se discute esta noción con el fin de entender sus raíces y desvelar sus presupuestos ideológicos. Al mismo tiempo, el término resiliencia presenta el interés de fomentar debates y cuestiones teóricas en el campo científico y en el sociopolítico de la formulación de nuevas políticas públicas. Más allá de los enfoques focalizados sobre el fortalecimiento de las capacidades locales, los aportes heurísticos del concepto de resiliencia para los análisis de riesgos en el medio urbano provienen de sus fundamentos en la teoría de los sistemas complejos. Así, se resaltan nuevos enfoques y soportes conceptuales que permiten entender mejor la vulnerabilidad de las grandes aglomeraciones urbanas.

  14. Elementos de reflexión sobre la resiliencia urbana: usos criticables y aportes potenciales

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    Pascale Metzger

    2013-06-01

    Full Text Available El propósito de este texto es discutir el concepto de resiliencia y buscar su interés heurístico para los análisis de vulnerabilidad urbana. El término resiliencia es omnipresente en la retórica de las declaraciones internacionales, de las políticas públicas y en las reflexiones académicas en el campo de los riesgos y desastres en ciudades. Se discute esta noción con el fin de entender sus raíces y desvelar sus presupuestos ideológicos. Al mismo tiempo, el término resiliencia presenta el interés de fomentar debates y cuestiones teóricas en el campo científico y en el sociopolítico de la formulación de nuevas políticas públicas. Más allá de los enfoques focalizados sobre el fortalecimiento de las capacidades locales, los aportes heurísticos del concepto de resiliencia para los análisis de riesgos en el medio urbano provienen de sus fundamentos en la teoría de los sistemas complejos. Así, se resaltan nuevos enfoques y soportes conceptuales que permiten entender mejor la vulnerabilidad de las grandes aglomeraciones urbanas.

  15. ESPÉCIES DA FAUNA URBANA DE MARABÁ E PARAUAPEBAS: CONHECER PARA PRESERVAR

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    André Santos Souza

    2014-10-01

    Full Text Available O crescimento acelerado das cidades fez com que a fauna silvestre migrasse das áreas de floresta e rios para conviver cada vez mais perto dos homens. Nas cidades de Marabá e Parauapebas, dois dos maiores centros urbanos do interior do Pará, alguns vertebrados podem ser observados na área urbana, convivendo com homens, carros, máquinas e concreto. Da compilação dos mais diversos estudos de fauna realizados nessas cidades e seus entornos, constam 297 espécies de vertebrados na área urbana de Marabá, das quais 87 foram visualizadas em trabalho de observação em campo; e 275 em Parauapebas, das quais 103 foram observadas em levantamento de campo. A pesquisa percorreu os quatro cantos de cada cidade, entre os meses de maio e setembro de 2013. Os resultados do estudo apontam para a necessidade premente de dar prosseguimento a levantamentos do gênero a fim de que as espécies sejam devidamente conhecidas, posto que algumas correm risco de desaparecimento.

  16. CityLog, verso nuove soluzioni per la distribuzione urbana delle merci

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    Saverio Zuccotti

    2010-07-01

    Full Text Available La logistica urbana rappresenta oggi una delle principali sfide per una mobilità sostenibile. La distribuzione delle merci in città paga infatti in competitività quei problemi di cui è in parte responsabile: traffico, inquinamento, incidenti etc. Negli ultimi anni la sensibilità su questi aspetti di sostenibilità ambientale è cresciuta in maniera netta, e a livello europeo molta strada è stata fatta per predisporre le risposte più adeguate. Il progetto europeo CityLog, finanziato nell’ambito del Settimo Programma Quadro, vede oggi collaborare diciotto partner europei coordinati dal Centro Ricerche Fiat per migliorare la logistica urbana agendo lungo tre direttrici: •\tservizi telematici orientati alla logistica, per dare un contributo decisivo al miglioramento della pianificazione delle missioni utilizzando strumenti per il routing ottimizzato dei veicoli e il supporto informativo costante agli autisti dei veicoli; •\tsoluzioni a bordo veicolo, che rappresentano un fattore chiave per aumentare la flessibilità operativa di camion e furgoni; •\tunità di carico innovative, accuratamente progettate per essere utilizzate su veicoli diversi in missioni diverse. Ne deriva pertanto una famiglia di container compatti con un layout interno riconfigurabile così da poter essere utilizzati per scopi diversi.

  17. REQUALIFICAÇÃO URBANA E DESPEJOS EM CENTROS NOVO E ANTIGO DE SALVADOR

    Directory of Open Access Journals (Sweden)

    John Gledhill

    Full Text Available A cidade de Salvador replica o processo de “acumulação por espoliação”, característico de um urbanismo neoliberal em todo o mundo. Neste artigo, comparamos como atua a lógica da requalificação urbana em duas zonas da cidade. A primeira é uma grande e historicamente combativa favela localizada na região que tem se tornado o mais moderno “novo centro” da cidade. Nela, a chave dos problemas são os novos projetos de mobilidade urbana e a construção de condomínios para outras classes sociais. A segunda zona é o centro colonial da cidade, que experimenta uma nova fase de gentrificação. Ali, as políticas de patrimônio histórico se encontram com outras políticas, transformando os remanescentes espaços públicos da cidade neoliberal securitizada em zonas mais seguras para turistas e residentes mais ricos. Enfatizamos o valor de um entendimento etnograficamente fundamentado para compreender o que essas mudanças significam para moradores pobres da cidade, assim como a complexidade, a heterogeneidade e a ambiguidade de suas diferentes reações.

  18. Influência de áreas verdes urbanas sobre a mirmecofauna

    Directory of Open Access Journals (Sweden)

    Milene Andrade Estrada

    Full Text Available O trabalho objetivou estudar a influência de características da arborização das áreas verdes urbanas sobre a mirmecofauna. A pesquisa foi conduzida no Município de Três Rios-RJ, em um parque urbano e em cinco praças públicas arborizadas. Foram obtidas a densidade de árvores, a densidade de espécies de árvores e a temperatura do ar. As formigas foram coletadas no solo e sobre o tronco de árvores, com iscas de sardinha. Foram coletadas 44 espécies de formigas, 26 espécies no solo e 37 espécies nas árvores. A densidade de espécies de árvores influenciou positivamente o número total de espécies de formigas e a diversidade de espécies coletadas nas árvores. Conclui-se que o aumento da densidade de espécies de árvores nas áreas verdes urbanas pode colaborar para a conservação da diversidade biológica.

  19. Recuperación de la renta urbana: Una tarea ética pendiente

    Directory of Open Access Journals (Sweden)

    Mario Torres

    2006-01-01

    Full Text Available Este artículo pretende contribuir a la discusión y proposición sobre la necesidad de recuperar las rentas generadas por el proceso de desarrollo urbano. Contrapone la visión económica, tributaria y moral del mercado de suelo, con el propósito de fundamentar la necesidad de la recuperación de la renta urbana. A fin de situar la problemática, fundamenta la existencia de un mercado de suelo altamente complejo e imperfecto, que precisa urgentes regulaciones. Asociado a ello, los beneficios otorgados por las normas tributarias -dado un conjunto de franquicias-, que favorecen la acumulación de la renta urbana en manos de los dueños de la tierra, estimulando la especulación, contribuyendo a la exclusión y a la inequidad en el acceso a bienes y servicios urbanos. Finalmente, considerando la categoría ética del bien común, exhorta a legislar para restablecer la función social de la tierra, a fin de resolver el dilema ético pendiente en la construcción de la ciudad

  20. Use of Cre/loxP recombination to swap cell binding motifs on the adenoviral capsid protein IX

    International Nuclear Information System (INIS)

    Poulin, Kathy L.; Tong, Grace; Vorobyova, Olga; Pool, Madeline; Kothary, Rashmi; Parks, Robin J.

    2011-01-01

    We used Cre/loxP recombination to swap targeting ligands present on the adenoviral capsid protein IX (pIX). A loxP-flanked sequence encoding poly-lysine (pK-binds heparan sulfate proteoglycans) was engineered onto the 3'-terminus of pIX, and the resulting fusion protein allowed for routine virus propagation. Growth of this virus on Cre-expressing cells removed the pK coding sequence, generating virus that could only infect through alternative ligands, such as a tyrosine kinase receptor A (TrkA)-binding motif engineered into the capsid fibre protein for enhanced infection of neuronal cells. We used a similar approach to swap the pK motif on pIX for a sequence encoding a single-domain antibody directed towards CD66c for targeted infection of cancer cells; Cre-mediated removal of the pK-coding sequence simultaneously placed the single-domain antibody coding sequence in frame with pIX. Thus, we have developed a simple method to propagate virus lacking native viral tropism but containing cell-specific binding ligands. - Highlights: → We describe a method to grow virus lacking native tropism but containing novel cell-binding ligands. → Cre/loxP recombination was used to modify the adenovirus genome. → A targeting ligand present on capsid protein IX was removed or replaced using recombination. → Cre-loxP was also used to 'swap' the identity of the targeting ligand present on pIX.

  1. Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice.

    Science.gov (United States)

    Verma, Dheeraj; Moghimi, Babak; LoDuca, Paul A; Singh, Harminder D; Hoffman, Brad E; Herzog, Roland W; Daniell, Henry

    2010-04-13

    To address complications of pathogenic antibody or life-threatening anaphylactic reactions in protein replacement therapy for patients with hemophilia or other inherited protein deficiencies, we have developed a prophylactic protocol using a murine hemophilia B model. Oral delivery of coagulation factor IX fused with cholera toxin beta-subunit (with or without a furin cleavage site; CTB-FFIX or CTB-FIX), expressed in chloroplasts (up to 3.8% soluble protein or 0.4 mg/g leaf tissue), bioencapsulated in plant cells, effectively blocked formation of inhibitory antibodies (undetectable or up to 100-fold less than controls). Moreover, this treatment eliminated fatal anaphylactic reactions that occurred after four to six exposures to intravenous F.IX. Whereas only 20-25% of control animals survived after six to eight F.IX doses, 90-93% of F.IX-fed mice survived 12 injections without signs of allergy or anaphylaxis. Immunostaining confirmed delivery of F.IX to Peyer's patches in the ileum. Within 2-5 h, feeding of CTB-FFIX additionally resulted in systemic delivery of F.IX antigen. This high-responder strain of hemophilia B mice represents a new animal model to study anaphylactic reactions. The protocol was effective over a range of oral antigen doses (equivalent to 5-80 microg recombinant F.IX/kg), and controlled inhibitor formation and anaphylaxis long-term, up to 7 months (approximately 40% life span of this mouse strain). Oral antigen administration caused a deviant immune response that suppressed formation of IgE and inhibitory antibodies. This cost-effective and efficient approach of antigen delivery to the gut should be applicable to several genetic diseases that are prone to pathogenic antibody responses during treatment.

  2. Transformación urbana y procesos territoriales recientes en Zaragoza y su espacio metropolitano

    Directory of Open Access Journals (Sweden)

    de Miguel González, Rafael

    2015-06-01

    Full Text Available In the last two decades the urban area of Zaragoza has experienced a high urban, residential and demographic growth, both in the metropolitan periphery, but especially in the central city. Thus, while the whole population urban area has grown 19%, new artificial land uses increased 71%. The recent development of Zaragoza has followed the general pattern of the major Spanish cities, even in the capital of Aragon urban transformations have been particularly intense due to the assumption of strategic projects (residential and business in the new Master Plan, to the effects on the urban structure of the arrival of high speed rail, and the appointment of Zaragoza to host the International Exposition of 2008. This has had some undeniable effects in modifying the shape of the city, but also in the organization, relationships and territorial processes of Zaragoza’s metropolitan area.En las últimas dos décadas el área urbana de Zaragoza ha conocido unos crecimientos urbanísticos, residenciales y demográficos elevados, tanto en la periferia metropolitana, pero sobre todo en la ciudad central, hasta llegar a la actual crisis económica e inmobiliaria. Así, mientras la población del conjunto del área urbana ha crecido el 19%, los nuevos suelos artificiales se incrementan el 71%. El reciente desarrollo urbanístico de Zaragoza ha seguido las pautas generales de las grandes ciudades españolas, aunque en la capital de Aragón las transformaciones urbanas han sido especialmente intensas debido a la asunción de proyectos estratégicos (residenciales y de actividad en el nuevo Plan General de Ordenación Urbana, a los efectos sobre la trama urbana de la llegada de la Alta Velocidad ferroviaria, así como la designación de la capital aragonesa como sede de la Exposición Internacional de 2008. Todo ello ha tenido unos indudables efectos en la modificación de la forma de la ciudad, pero también en la organización, en las relaciones y en los procesos

  3. Violência urbana: um desafio para o pediatra Urban violence: a challenge for pediatricians

    Directory of Open Access Journals (Sweden)

    Luciana Phebo

    2005-11-01

    Full Text Available OBJETIVOS: Apresentar os principais aspectos da abordagem da criança e do adolescente vítima de violência urbana e destacar o papel do pediatra nas ações socioeducativas para o seu enfrentamento. FONTES DOS DADOS: Busca bibliográfica em base de dados MEDLINE, LILACS e SciELO, no período de 1993 a 2005, utilizando as palavras-chave "violência urbana em crianças e adolescentes". Políticas e relatórios institucionais sobre violência urbana também foram utilizados. SÍNTESE DE DADOS: Apresenta-se uma discussão sobre a relação causal da violência, partindo de um enfoque pessoal até chegar a uma visão macroestrutural. A literatura sugere que a violência urbana seja um produto da ação de determinantes pertencentes à várias instâncias e também de comportamento de risco específico. Trata-se de um fenômeno complexo, preocupante, que apresenta elevados índices de morbimortalidade em crianças e adolescentes. Especial atenção foi dada aos homicídios e aos desfechos psicológicos decorrentes de atos violentos. A arma de fogo é o instrumento que mais mata os adolescentes e jovens do sexo masculino, mesmo quando comparada com todas as outras causas de óbito nessa faixa etária. CONCLUSÕES: A violência urbana é um dos principais problemas sociais no Brasil. Sua prevenção exige ações intersetoriais e multiprofissionais, com a participação articulada do Estado e da sociedade civil. Através de uma prática assistencial ampliada, os pediatras são capazes de atuar na prevenção, detecção e tratamento das vítimas e suas famílias, ajudando-as a estabelecer relações saudáveis e dinâmicas com seu ambiente e com elas próprias.OBJECTIVES: To present the main aspects of an approach to urban violence among children and adolescents and to point out the social and educational role of pediatricians. SOURCES OF DATA: A literature review based on MEDLINE, LILACS and SciELO was carried out for the years 1993 to 2005, using

  4. Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the Ihh-PTHrP feedback loop.

    Science.gov (United States)

    Kamper, Matthias; Paulsson, Mats; Zaucke, Frank

    2017-02-01

    Collagen IX (Col IX) is a component of the cartilage extracellular matrix and contributes to its structural integrity. Polymorphisms in the genes encoding the Col IX ɑ2- and ɑ3-chains are associated with early onset of disc degeneration. Col IX-deficient mice already display changes in the spine at the newborn stage and premature disc degeneration starting at 6 months of age. To determine the role of Col IX in early spine development and to identify molecular mechanisms underlying disc degeneration, the embryonic development of the spine was analyzed in Col IX -/- mice. Histological staining was used to show tissue morphology at different time points. Localization of extracellular matrix proteins as well as components of signaling pathways were analyzed by immunohistochemistry. Developing vertebral bodies of Col IX -/- mice were smaller and already appeared more compact at E12.5. At E15.5, vertebral bodies of Col IX -/- mice revealed an increased number of hypertrophic chondrocytes as well as enhanced staining for the terminal differentiation markers alkaline phosphatase and collagen X. This correlates with an imbalance in the Ihh-PTHrP signaling pathway at this time point, reflected by an increase of Ihh and a concomitant decrease of PTHrP expression. An accelerated hypertrophic differentiation caused by a disturbed Ihh-PTHrP signaling pathway may lead to a higher bone mineral density in the vertebral bodies of newborn Col IX -/- mice and, as a result, to the early onset of disc degeneration.

  5. Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth, But Does Not Modulate Daunorubicin or Cisplatin Cytotoxicity.

    Science.gov (United States)

    Riemann, Anne; Güttler, Antje; Haupt, Verena; Wichmann, Henri; Reime, Sarah; Bache, Matthias; Vordermark, Dirk; Thews, Oliver

    2018-03-05

    Carbonic anhydrase (CA) IX has emerged as a promising target for cancer therapy. It is highly upregulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment, which promotes tumor aggressiveness via various mechanisms, such as augmenting metastatic potential. Therefore, the aim of this study was to analyze the complex interdependency between CA IX and the tumor microenvironment in prostate tumor cells with regard to potential therapeutic implications. CA IX was upregulated by hypoxia as well as acidosis in prostate cancer cells. This induction did not modulate intracellular pH but led to extracellular acidification. Pharmacological inhibition of CA IX activity by U104 (SLC-0111) resulted in a reduction in tumor cell growth and an increase in apoptotic cell death. Intracellular pH was reduced under normoxic and even more so under hypoxic conditions when CA IX level was high. However, although intracellular pH regulation was disturbed, targeting CA IX in combination with daunorubicin or cisplatin did not intensify apoptotic tumor cell death. Hence, targeting CA IX in prostate cancer cells can lead to intracellular pH dysregulation and, consequently, can reduce cellular growth and elevate apoptotic cell death. Attenuation of extracellular acidification by blocking CA IX might additionally impede tumor progression and metastasis. However, no beneficial effect was seen when targeting CA IX in combination with chemotherapeutic drugs.

  6. Efectos de la entropía urbana en el coste energético del trasporte

    Directory of Open Access Journals (Sweden)

    Francisco Bascuñán Walker

    2011-05-01

    Full Text Available El objetivo del trabajo presentado fue descubrir los efectos de la diversidad de uso de suelo o entropía urbana sobre el gasto energético del transporte. Se eligió como zona de estudio la ciudad de La Serena y se encuestó a un grupo representativo de familias con gastos energéticos y de estratos sociales diversos y se comparó con las zonas urbanas de diferentes grados de entropía. El estudio mostró que, indistintamente del nivel social, los habitantes de las zonas que mostraban niveles mayores de entropía gastaban menos energía en traslados a destinos urbanos que aquellos que vivían en zonas de menores entropías. Basados en los resultados del estudio se concluyó que para disminuir el gasto energético en trasporte de los habitantes de la ciudad se requería incrementar el nivel de entropía. La alternativa más eficiente estudiada fue contemplar en la planificación urbana, pequeños policentros de multiservicios (más de tres servicios diferentes que cubran una superficie de población urbana de 78 has aproximadamente.

  7. El territorio municipal: caminos, parcelaciones y poblamiento. El espacio público: gobierno municipal y sociedad urbana

    OpenAIRE

    Arasa i Gil, Ferran

    1999-01-01

    Se trata de dos capítulos de la Historia de la ciudad de Valencia en los que se abordan cuestiones relacionadas con el paisaje rural como el poblamiento, los caminos y las parcelaciones; y con el gobierno local y la sociedad urbana.

  8. Brote de rabia urbana transmitida por perros en el distrito de Santa Marta, Colombia, 2006-2008

    Directory of Open Access Journals (Sweden)

    Andrés Páez

    2009-09-01

    El control del brote se logró 20 meses después del primer caso en perros y 14 meses después de haberse iniciado la primera vacunación masiva en animales. Es necesario implementar y mantener acciones para el control de la rabia urbana y evitar su impacto en los humanos.

  9. El Plan Especial de transformación urbana del barrio de La Mina, Barcelona, Premio Nacional de Urbanismo

    OpenAIRE

    Urban, Editor

    2011-01-01

    Lo que ha ido ocurriendo en el barrio de La Mina en los últimos 30 años es un magnífico ejemplo de las luces y sombras que rodean la gran transformación urbana, económica y social que ha sacudido la ciudad de Barcelona y su entorno en estos decenios.

  10. El impacto de la sociedad urbana en la identidad cultural de los estudiantes universitarios Shuar residentes en Quito

    OpenAIRE

    Wisum Saant, Payar Celestino

    1999-01-01

    Introduction. Framework. Culture and identity. The identity. The Shuar identity. Urban society. Conceptual framework. Conclusions and recommendations. Notes. General bibliography. Introducción. Marco referencial. La cultura e identidad. La identidad. La identidad shuar. La sociedad urbana. Marco conceptual. Conclusiones y recomendaciones. Notas. BIbliografía general.

  11. Violencia basada en género en zonas urbanas y urbano-marginales de Lima y Callao, 2007 - 2010

    Directory of Open Access Journals (Sweden)

    Pedro Mascaro-Sánchez

    2012-04-01

    Full Text Available Objetivos: Determinar y comparar las características de la violencia en pobladores de zonas urbanas y urbano-marginales. Diseño: Estudio epidemiológico descriptivo. Institución: Escuela de Obstetricia, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. Participantes: Mujeres de Lima y Callao. Intervenciones: Entre los años 2007 y 2010, se aplicó una entrevista estructurada a 3 971 mujeres de zonas urbanas y urbano-marginales de Lima y Callao. Se incluyó mujeres residentes de la zona, excluyéndose aquellas con problemas psicológicos evidentes y problemas del habla. Los datos fueron analizados con estadísticas descriptivas y con el estadístico chi cuadrado, significativo a un nivel p<0,05. Principales medidas de resultados: Violencia física. Resultados: De las entrevistadas, 39% tenía entre 20 y 24 años de edad. El 47% identificó violencia física, siendo similar en zonas urbanas y urbano-marginales. Los empujones y bofetadas fueron la forma más frecuente de violencia en ambas áreas. Con respecto al estudio de la violencia psicológica, fueron más frecuentes la utilización de gritos y celos por posesividad, también en ambas áreas. El gasto de la pareja sin la consulta fue ligeramente mayor para el área urbano marginal (49% que para el área urbana (42%. El intento de tener relaciones sexuales contra su voluntad fue el tipo de violencia más frecuente (37%, más en el área urbana (41% que en el área urbano marginal (34%. Conclusiones: Se evidenció episodios de violencia física, psicológica, económica y sexual similares para el área urbana y el área urbano-marginal, siendo la violencia sexual más frecuente en el área urbana.

  12. The rates and patterns of deletions in the human factor IX gene

    Energy Technology Data Exchange (ETDEWEB)

    Ketterling, R.P.; Vielhaber, E.L.; Lind, T.J.; Thorland, E.C.; Sommer S.S. (Mayo Clinic/Foundation, Rochester, MN (United States))

    1994-02-01

    Deletions are commonly observed in genes with either segments of highly homologous sequences or excessive gene length. However, in the factor IX gene and in most genes, deletions (of [ge]21 bp) are uncommon. The authors have analyzed DNA from 290 families with hemophilia B (203 independent mutations) and have found 12 deletions >20 bp. Eleven of these are >2 kb (range >3-163 kb), and one is 1.1 kb. The junctions of the four deletions that are completely contained within the factor IX gene have been determined. A novel mutation occurred in patient HB128: the data suggest that a 26.8-kb deletion occurred between two segments of alternating purines and pyrimidines and that a 2.3-kb sense strand segment derived from the deleted region was inserted. For a sample of 203 independent mutations, the authors estimate the [open quotes]baseline[close quotes] rates of deletional mutation per base pair per generation as a function of size. The rate for large (>2 kb)I deletions is exceedingly low. For every mutational event in which a given base is at the junction of a large deletion, there are an estimated 58 microdeletions (<20 bp) and 985 single-base substitutions at that base. Analysis of the nine reported deletion junctions in the factor IX gene literature reveals that (i) five are associated with inversion, orphan sequences, or sense strand insertions; (ii) four are simple deletions that display an excess of short direct repeats at their junctions; (iii) there is no dramatic clustering of junctions within the gene; and (iv) with the exception of alternating purines and pyrimidines, deletion junctions are not preferentially associated with repetitive DNA. 58 refs., 5 figs., 5 tabs.

  13. Comparison of Ares I-X Wind-Tunnel Derived Buffet Environment with Flight Data

    Science.gov (United States)

    Piatak, David J.; Sekula, Martin K.; Rausch, Russ D.

    2011-01-01

    The Ares I-X Flight Test Vehicle (FTV), launched in October 2009, carried with it over 243 buffet verification pressure sensors and was one of the most heavily instrumented launch vehicle flight tests. This flight test represented a unique opportunity for NASA and its partners to compare the wind-tunnel derived buffet environment with that measured during the flight of Ares I-X. It is necessary to define the launch vehicle buffet loads to ensure that structural components and vehicle subsystems possess adequate strength, stress, and fatigue margins when the vehicle structural dynamic response to buffet forcing functions are considered. Ares I-X buffet forcing functions were obtained via wind-tunnel testing of a rigid buffet model (RBM) instrumented with hundreds of unsteady pressure transducers designed to measure the buffet environment across the desired frequency range. This paper discusses the comparison of RBM and FTV buffet environments, including fluctuating pressure coefficient and normalized sectional buffet forcing function root-mean-square magnitudes, frequency content of power-spectral density functions, and force magnitudes of an alternating flow phenomena. Comparison of wind-tunnel model and flight test vehicle buffet environments show very good agreement with root-mean-square magnitudes of buffet forcing functions at the majority of vehicle stations. Spectra proved a challenge to compare because of different wind-tunnel and flight test conditions and data acquisition rates. However, meaningful and promising comparisons of buffet spectra are presented. Lastly, the buffet loads resulting from the transition of subsonic separated flow to supersonic attached flow were significantly over-predicted by wind-tunnel results.

  14. Fontes de financiamento para planos de mobilidade urbana: a sistematização das janelas de oportunidade de financiamento geridas pelo Ministério das Cidades

    OpenAIRE

    Ruiz, Isadora

    2015-01-01

    O presente trabalho tem como objetivo a sistematização das janelas de oportunidade de financiamento de elaboração e implementação dos Planos de Mobilidade Urbana, atualmente geridas pelo Ministério das Cidades. Para tanto, foi primeiramente realizado um diagnóstico da Mobilidade Urbana no Brasil, desenvolvido o conceito de Plano de Mobilidade Urbana, bem como identificadas as janelas de oportunidade de financiamento. Em seguida, o trabalho descreve em detalhes cada uma das janelas de oportuni...

  15. The 3d84s-3d84p transitions in Br IX

    International Nuclear Information System (INIS)

    Zeng, X.T.; Jupen, C.; Livingston, A.E.; Westerlind, M.; Engstroem, L.; Martinson, I.

    1990-01-01

    The spectrum of bromine was studied in the region 450-1100 A, using the beam-foil method with 6 MeV ions from a tandem accelerator. On the basis of isoelectronic extrapolations and theoretical calculations, 32 lines were classified as transitions between the 3p 6 3d 8 4s and 3p 6 3d 8 4p configurations of Co-like BrIX. Fo the 16 possible 4s levels 13 have been located, and 11 new 4p levels have been added to the previously known ones. Only 4 of all the 4p levels (45 in total) remain to be found. (orig.)

  16. Syntheses of protoporphyrin-IX regioselectivity carbon-13 labelled at the alpha-vinyl carbons

    International Nuclear Information System (INIS)

    Smith, K.M.; Fujinari, E.M.

    1986-01-01

    A method for transformation of readily available beta-vinyl 99% carbon-13 enriched derivatives of protoporphyrin-IX dimethyl ester into the less accessible alpha-vinyl labelled isomers is described. The procedure involves thallium(III) promoted vinyl carbon rearrangement, and proceeds through 2,2-dimethoxyethyl, formylmethyl, 2-hydroxyethyl and 2-chloroethyl porphyrins; the rearranged vinyl groups are regenerated from 2-chloroethyl in the last step by treatment with base. No evidence of vinyl carbon scrambling in the sequence is observed, and spectroscopic data of the products are given. (author)

  17. Prophylactic use of factor IX concentrate in a Jehovah's Witness patient.

    Science.gov (United States)

    Bolliger, Daniel; Sreeram, Gautam; Duncan, Alexander; Molinaro, Ross J; Szlam, Fania; Chen, Edward P; Tanaka, Kenichi A

    2009-11-01

    In Jehovah's Witness patients, the use of red blood cells, platelets, and fresh frozen plasma is not optional. Various blood conservation techniques are available, but complex cardiac surgery remains a major challenge. The feasibility of fractions of "primary components" has not been fully considered in published case reports. For Jehovah's Witness patients who preoperatively give consent, factor IX concentrates may be acceptable for hemostatic therapy. We hereby describe a combination of "secondary components" to prevent excessive bleeding in a Jehovah's Witness patient undergoing complex replacement of the aortic arch.

  18. IX Simposio Ibérico sobre Nutrición Mineral de las Plantas

    OpenAIRE

    Abadía Bayona, Javier

    2003-01-01

    Del 10 al 13 de Septiembre de 2002 se celebró el IX Simposio Ibérico sobre Nutrición Mineral de las Plantas en el Campus de Aula Dei de Zaragoza. El Simposio se realizó bajo los auspicios de la Sociedad Española de Fisiología Vegetal, el Consejo Superior de Investigaciones Científicas (CSIC), el Instituto Agronómico Mediterráneo de Zaragoza-Centro Internacional de Altos Estudios Agronómicos Mediterráneos (CIHEAM-IAMZ), la Asociación Internacional para la Optimización de...

  19. Spectral analysis of the 4d96s configuration in eight times ionized xenon, Xe IX

    International Nuclear Information System (INIS)

    Raineri, M.; Gallardo, M.; Reyna Almandos, J.G.

    2006-01-01

    A capillary light source was used to observe the spectrum of eight times ionized xenon, Xe IX, in the vacuum ultraviolet range, 270-2000 A. Sixteen transitions have been identified as combinations between energy levels of the 4d 9 6s with 4d 9 5p configuration, and all 4d 9 6s levels have been determined. The present analysis is based on an accurate extrapolation of energy parameters and experimental energy level values in the Pd I isoelectronic sequence. The energy parameters were obtained with Hartree-Fock relativistic calculations. Least-squares parametric calculation has been carried out to study the fit between experimental and theoretical values

  20. Weighted oscillator strengths and lifetimes for the S IX and S X spectra

    International Nuclear Information System (INIS)

    Borges, F.O.; Cavalcanti, G.H.; Trigueiros, A.G.

    2003-01-01

    The weighted oscillator strengths (gf) and the lifetimes presented in this work were carried out in a multi configuration Hartree-Fock relativistic (HFR) approach. In this calculation, the electrostatic parameters were optimized by a least-squares procedure, in order to improve the adjustment to experimental energy levels. This method produces gf-values that are in better agreement with intensity observations and lifetime values that are closer to the experimental ones. In this work, we presented all the experimentally known electric dipole S IX and S X spectral lines

  1. The Ripple Effect of Title IX on Women's Health Issues: Treating an Increasingly Active Population.

    Science.gov (United States)

    Mees, Patricia D

    2003-04-01

    Perhaps no area in sports medicine has changed as dramatically in the last 30 years as women's health. Title IX of the Education Amendments of 1972 prohibited discrimination on the basis of sex in all curricular and extracurricular activities at educational institutions that receive federal funding. Before 1972, many assumed that women were not interested in sports and that there was no need to provide programs for girls and women, and most primary care physicians had little experience in treating female athletes and other active women.

  2. Collateral patient doses in the Varian 21iX radiotherapy Linac

    International Nuclear Information System (INIS)

    Barquero, R.; Castillo, A. del

    2008-01-01

    Full text: The radiotherapy aim is to irradiate the patient tumor cells while the doses in healthy tissue remains as low as possible. Nevertheless, when high photon energy accelerators are used, collateral undesired photon and neutron doses are always implied during the treatments and became more important with the new accelerators and techniques as IMRT. To assess secondary cancer risk outside the treatment volume as a long-term medical consequence of treatments, the total doses received by each patient outside the primary field during his treatment must be estimated. To achieve this purpose photon and neutron dose equivalents Hp(10) and H*(10) has been measured in a new Varian 21iX with maximum photon energy of 15 MV placed recently in our radiotherapy department. Three devices: 1) a neutron dose rate meter BERTHOLD LB 4111 calibrated recently in the German PTB laboratory, 2) a calibrated environmental pressurized photon ionization chamber (IC) VICTOREEN 450-PI n/s 1020, and 3) a calibrated personal electronic photon dosimeter GAMMACOM 4200M, were placed above the treatment couch outside the primary field while the Varian 21iX reference test were done. In particular the photon and neutron doses in the couch were measured while a water phantom was irradiated during automatic beam data acquisition for a 15 MV beam. A complete set of measurements changing field size are made. These 15 MV results are compared with data measured previously by thermoluminescence and bubble dosimeters in the same facility for an Elekta Precise and a Siemens KDS both with maximum photon energy of 18 MV. From this the benefits in the patient collateral doses of decreasing the maximum treatment photon energy are discussed. The patient doses obtained in the Varian 21iX had values that go from 80 to 800 uSv per treatment Gray. As the Varian 21iX therapy Linac is operated in pulsed mode with short pulse length the discussion of the results includes: 1. The correction of dead time in the GM

  3. Unity in John 17 and in IQS I-IX: A comparative study

    Directory of Open Access Journals (Sweden)

    B. W. de Wet

    1997-08-01

    Full Text Available The unity theme as it is found in John 17 and in IQS I-IX provides sufficient comparative material to give an indication of the extent to which John�s theology flourished within the contemporary Jewish context. It is argued that the events surrounding Christ constituted for John the central point of orientation according to which the typical Jewish ideas could be interpreted and reformulated. It is finally concluded that, according to this radical and exclusive Christian dynamic approach, certain elements within Judaism, also found among members of the Qumran community, were reinterpreted, while others were either continued or discontinued.

  4. Modelo de avaliação do nível de sustentabilidade urbana: proposta para as cidades brasileiras

    Directory of Open Access Journals (Sweden)

    Maria de Fátima Martins

    2015-09-01

    Full Text Available Os indicadores de sustentabilidade permitem captar características do ambiente urbano e revelar a (in sustentabilidade urbana, gerando informações que dão suporte às políticas públicas e ao processo de desenvolvimento. A partir dessa constatação, o objetivo do artigo é propor um modelo para análise da sustentabilidade urbana, construído a partir das matrizes de Acselrad (2009. Tal proposta é dividida em: uma abordagem conceitual, marco ordenador para avaliação da sustentabilidade do espaço urbano, no sentido de unificar o entendimento sobre a sustentabilidade pelos diversos públicos interessados; e uma abordagem operacional, que define as matrizes, as dimensões e os temas para análise da sustentabilidade, com seus respectivos critérios de análises, indicadores e parâmetros de operacionalização, que permitem o monitoramento da sustentabilidade das cidades, servindo como instrumento para orientação das políticas públicas urbanas. Em termos metodológicos, trata-se de um ensaio teórico baseado na literatura sobre sustentabilidade urbana, especialmente acerca das matrizes discursivas. A importância do trabalho refere-se ao fato de o modelo permitir a análise da sustentabilidade urbana, dadas as especificidades da problemática das cidades brasileiras. Em termos de contribuição, é importante por gerar subsídios para análises mais consistentes desses problemas e, por meio de indicadores urbanos e de critérios de análises, possibilitar uma orientação para o processo de desenvolvimento urbano e de monitoramento da sustentabilidade das cidades, oferecendo suporte às políticas públicas.

  5. Integrando la gestión del riesgo, planificación urbana y vivienda social: lecciones de El Salvador

    Directory of Open Access Journals (Sweden)

    Christine Wamsler

    2007-01-01

    Full Text Available Más atención se está dando a la necesidad de integrar la gestión del riesgo en el trabajo de desarrollo para poder reducir así la vulnerabilidad de los pobres que viven en áreas urbanas. Usando El Salvador como estudio de caso, este artículo analiza el proceso de integración en dos sectores de desarrollo: planificación urbana y vivienda social. El objetivo es identificar de qué manera se puede superar la separación existente entre gestión del riesgo, planificación urbana y vivienda social. A partir del Huracán Mitch, y después de los terremotos del 2001, las organizaciones de vivienda social en El Salvador empezaron a abordar las causas subyacentes de la vulnerabilidad urbana. A pesar de experiencias positivas en la implementación de proyectos más integrales, la creación de marcos operativos, organizacionales, institucionales y legales adecuados aún se encuentran en etapa inicial. Lamentablemente, los fondos disponibles para la gestión del riesgo post-desastre llegaron a su fin, sin una asignación de recursos para la consolidación del proceso iniciado. El artículo propone un modelo para integrar la gestión del riesgo en la planificación urbana y en la vivienda social, de manera que dicho proceso sea más inclusivo y sostenible dentro del contexto de desarrollo.

  6. El diálogo de saberes en investigaciones de ecología urbana: narrativas locales, cotidianidad e interdisciplinariedad

    Directory of Open Access Journals (Sweden)

    Dayana Ortiz

    2017-11-01

    Full Text Available El modelo de desarrollo económico global sobre el cual se sustentan las ciudades en la actualidad ha devenido en procesos metabólicos que impactan negativamente las condiciones de vida del ser humano en el entramado ecológico urbano. Con base en esta problemática, han emergido campos de investigación que intentan abordar los estudios urbanos desde enfoques que profundicen situaciones complejas, entre los cuales puede ubicarse la ecología urbana. Así, partiendo de algunos postulados de la ecología urbana desde el enfoque de “ecología de la ciudad”, en este trabajo se analiza la importancia de la incorporación del diálogo de saberes a partir de narrativas locales en investigaciones ecológicas urbanas desde miradas interdisciplinarias que integran la ecología tradicional, el urbanismo, la psicología social, la economía, la antropología, la geografía, la sociología y la historia. Para ello, se presentan algunas experiencias de Investigación Acción Participativa a escala local en comunidades de la ciudad de Caracas, Venezuela, desde las cuales se propone la incorporación de métodos interdisciplinarios en la ecología urbana. Este tipo de investigación constituye una aproximación importante a la dimensión fenomenológica de las experiencias cotidianas de vida urbana, la cual es preponderante para el estudio de las dinámicas ecológicas de los ecosistemas urbanos.

  7. A QUESTÃO DA MOBILIDADE URBANA NAS METRÓPOLES BRASILEIRAS

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    Valéria Pero

    2015-12-01

    Full Text Available RESUMO O tempo de deslocamento de casa ao trabalho tem se elevado substancialmente nas regiões metropolitanas brasileiras durante a última década. Esse fenômeno tem implicações fortes sobre o bem-estar dos indivíduos, porém as consequências desse problema não se distribuem uniformemente entre a população. O presente trabalho visa contribuir para o debate sobre a questão da mobilidade urbana nas metrópoles brasileiras analisando a evolução do tempo de deslocamento entre 1992 e 2013 e suas diferenças de acordo com características do trabalhador, como sexo, cor e renda per capita , e do posto de trabalho. Verifica-se que o aumento do tempo médio de deslocamento ocorreu a partir de 2003, caracterizando uma questão particularmente importante para as metrópoles brasileiras no terceiro milênio. Os trabalhadores com maiores tempos médios de deslocamento residem nas regiões metropolitanas do Rio de Janeiro e de São Paulo. Entretanto, as maiores taxas de crescimento ocorreram nas metrópoles do Pará, Salvador e Recife, sugerindo a necessidade de melhor direcionamento e planejamento de políticas públicas na mobilidade urbana. Considerando as diferenças socioeconômicas, destaca-se que os mais pobres e os mais ricos (extremos da distribuição de renda tendem a apresentar tempos de deslocamento menores do que os trabalhadores de famílias de renda média. Esse padrão se mantém ao longo do tempo, com aumento do tempo médio de deslocamento entre os mais pobres, mostrando uma face da desigualdade. Porém, o maior aumento ocorreu entre os mais ricos, colocando a questão da mobilidade urbana para além dos problemas de exclusão social.

  8. A estética urbana no projeto de Saturnino de Brito (1887-1929

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    Juliana Bandeira de Arruda

    2006-12-01

    Full Text Available O presente texto foi desenvolvido a partir do Projeto de Pesquisa do Mestrado no Programa de Pós-Graduação em Desenvolvimento Urbano (MDU/UFPE, 2006, e traz uma abordagem do pensamento estético-paisagístico de Saturnino de Brito, engenheiro reconhecido por suas obras sanitaristas e também considerado um dos primeiros urbanistas modernos a ter uma visão de cidade em sua totalidade e enquanto obra de arte. O objetivo principal é compreender a gênese do paisagismo no Brasil a partir das práticas de Saturnino de Brito pelas cidades brasileiras, por meio de uma caracterização da estética urbana implantada por Saturnino de Brito em suas obras de saneamento, melhoramentos e expansão nessas cidades. Discute-se também quais os princípios paisagísticos empregados em particular no Recife que direcionaram o Plano de Melhoramentos para a cidade e algumas das práticas políticas atuais. A pesquisa considerou os principais planos de saneamento, melhoramentos e expansão das cidades brasileiras, dentre eles: Vitória – ES (1896-1926, Santos – SP (1905-1910, Recife – PE (1909-1915, Pelotas – RS (1927-1929 e Natal (1935-1939. Neles, focalizando o principal elemento estruturador desses planos e, de sua paisagem: os canais de drenagem a céu aberto. Dessa forma, diante da constatação do crescente desenvolvimento das cidades, uma consciência das práticas urbanas relacionadas a história do lugar torna a discussão do tratamento da paisagem urbana primordial para a visão de uma cidade saudável e que respeite as raízes de sua formação.

  9. Herramientas para evaluar la sostenibilidad de las intervenciones urbanas en barrios

    Directory of Open Access Journals (Sweden)

    Simón-Rojo, M.

    2011-10-01

    Full Text Available Integrating assessment tools in the decision making process of urban design may contribute to tackle the defining challenges of sustainability that our cities face. The research works on practical tools to compare alternatives taking into account sustainability criteria that incorporate quantitative as well as qualitative assessment. Effective assessment tools that take into account socioeconomic criteria are required to push forward integrated urban planning policies that can shape interventions at neighbourhood scale. This paper presents the conclusions after the review of assessment tools available in the European context. These tools are focussed mainly on delivering reports and guidelines, list of indicators and best practices; besides those reports, also some methodologies and specific technologies have been developed. Nevertheless there is a lack of practical, useful and open source tools to assess urban sustainability of urban small scale interventions.

    El empleo en la planificación y en el diseño de intervenciones de mejora urbana, de herramientas que permitan comparar alternativas con criterios de sostenibilidad, contribuiría a afrontar algunos de los retos fundamentales a los que se enfrentan nuestras ciudades. Desde la Unión Europea se aboga por políticas urbanas integrales. Para lograrlas sería recomendable contar con herramientas de evaluación adecuadas, que incorporen los aspectos socioeconómicos y se puedan aplicar en la escala de barrio. El artículo presenta las conclusiones de la revisión de herramientas para evaluar la sostenibilidad urbana en el contexto europeo. Estas herramientas aportan sobre todo informes, guías, indicadores y buenas prácticas. En algún caso se han desarrollado metodologías y tecnologías específicas. A pesar de la gran cantidad de recursos públicos invertidos, sigue habiendo una carencia de herramientas prácticas, útiles y de código abierto que permitan evaluar la

  10. Factor IX[sub Madrid 2]: A deletion/insertion in Facotr IX gene which abolishes the sequence of the donor junction at the exon IV-intron d splice site

    Energy Technology Data Exchange (ETDEWEB)

    Solera, J. (Unidades de Genetica Molecular, Madrid (Spain)); Magallon, M.; Martin-Villar, J. (Hemofilia Hospital, Madrid (Spain)); Coloma, A. (Departamento deBioquimica de la Facultad de Medicina de la Universidad Autonoma, Madrid (Spain))

    1992-02-01

    DNA from a patient with severe hemophilia B was evaluated by RFLP analysis, producing results which suggested the existence of a partial deletion within the factor IX gene. The deletion was further localized and characterized by PCR amplification and sequencing. The altered allele has a 4,442-bp deletion which removes both the donor splice site located at the 5[prime] end of intron d and the two last coding nucleotides located at the 3[prime] end of exon IV in the normal factor IX gene; this fragment has been inserted in inverted orientation. Two homologous sequences have been discovered at the ends of the deleted DNA fragment.

  11. Intracellular localization analysis of npAu-PpIX in HeLa cells using specific dyes and confocal microscopy

    Science.gov (United States)

    Roblero-Bartolón, Victoria Gabriela; Maldonado-Alvarado, Elizabeth; Galván-Mendoza, José Iván; Ramón-Gallegos, Eva

    2012-10-01

    Cervical carcinoma (CC) represents the second leading cause of cancer death in Mexican women. No conventional treatments are being developed such as photodynamic therapy (PDT), involving the simultaneous presence of a photosensitizer (Ps), light of a specific wavelength and tissue oxygen. On the other hand, it has seen that the use of gold nanoparticles coupled to protoporphyrin IX increases the effectiveness of PDT. The aim of this study was to determine the site of accumulation of the conjugate npAu-PpIX in cells of cervical cancer by the use of specific dyes and confocal microscopy. The results indicate that the gold nanoparticles coupled to protoporphyrin IX are accumulated in both the cytoplasm and nucleus of HeLa cells.

  12. Tissue factor-dependent activation of tritium-labeled factor IX and factor X in human plasma

    International Nuclear Information System (INIS)

    Morrison, S.A.; Jesty, J.

    1984-01-01

    A comparism was made of the tissue factor-dependent activation of tritium-labeled factor IX and factor X in a human plasma system and a study was made of the role of proteases known to stimulate factor VII activity. Plasma was defibrinated by heating and depleted of its factors IX and X by passing it through antibody columns. Addition of human brain thromboplastin, Ca2+, and purified 3H-labeled factor X to the plasma resulted, after a short lag, in burst-like activation of the factor X, measured as the release of radiolabeled activation peptide. The progress of activation was slowed by both heparin and a specific inhibitor of factor Xa but factor X activation could not be completely abolished by such inhibitors. In the case of 3H-factor IX activation, the rate also increased for approximately 3 min after addition of thromboplastin, but was not subsequently curtailed. A survey of proteases implicated as activators of factor VII in other settings showed that both factor Xa and factor IXa could accelerate the activation of factor IX. However, factor Xa was unique in obliterating activation when present at concentrations greater than approximately 1 nM. Heparin inhibited the tissue factor-dependent activation of factor IX almost completely, apparently through the effect of antithrombin on the feedback reactions of factors Xa and IXa on factor VII. These results suggest that a very tight, biphasic control of factor VII activity exists in human plasma, which is modulated mainly by factor Xa. At saturation of factor VIIa/tissue factor, factor IX activation was significantly more rapid than was previously found in bovine plasma under similar conditions. The activation of factor X at saturation was slightly more rapid than in bovine plasma, despite the presence of heparin

  13. Videografia Aérea Multiespectral em Silvicultura UrbanaAerial Multiespectral Videography in Urban Forestry

    OpenAIRE

    Silva Filho, Demóstenes Ferreira da

    2009-01-01

    Admitindo-se como hipótese básica a possibilidade do uso de imagens aéreas multiespectrais para classificação automática em classes de vegetação, objetivou-se, mediante comparações estatísticas entre dados de solo e videografia aérea multiespectral, avaliar a aplicação e uso de imagens multiespectrais de alta resolução para identificação, classificação e quantificação das estruturas urbanas, cobertura vegetal proporcionada pelas árvores. Após sobrevôo e mosaico, foram feitas análises estatíst...

  14. NATURACIÓN URBANA, UN DESAFÍO A LA URBANIZACIÓN

    Directory of Open Access Journals (Sweden)

    Beatriz Urbano-López de Meneses

    2013-01-01

    Full Text Available La naturación urbana es la acción de incorporar la vegetación al medio urbano con el objetivo de amortiguar el desequilibrio entre la urbanización y la conservación del medio ambiente. Este artículo de revisión repasa los problemas ambientales, hidrológicos, de gestión de residuos, salubres y sociales que combate la naturación. Los sistemas respectivos se clasifican según la superficie naturada y la complejidad del sistema. Las capas básicas del sistema de naturación y los materiales que se emplean son analizados. Finalmente, se presentan las principales líneas de trabajo para el desarrollo e integración de los sistemas de naturación en la construcción de ciudades sostenibles.

  15. Métodos de regulación de tráfico para redes urbanas

    OpenAIRE

    Canca Ortiz, José David

    1996-01-01

    En esta tesis se analiza el problema de la regulación de señales semafóricas en redes urbanas y su integración en un sistema de control del tráfico. La clasificación más habitual de los sistemas de control de tráfico se basa en la posibilidad de respuesta de los mismos frente a los continuos cambios en la evolución del comportamiento d el tráfico. Desde este punto de vista se pueden distinguir sistemas a tiempo fijo, semidinámicos y dinámicos (de segunda y tercera generación). El objetivo de ...

  16. Arquitetura residencial urbana: Espírito Santo do Pinhal, 1880-1930

    OpenAIRE

    Camila Corsi Ferreira

    2011-01-01

    Estuda a arquitetura residencial urbana em Espírito Santo do Pinhal, região paulista de economia cafeeira. Insere-se no contexto de produção de casarões urbanos patrocinados pela riqueza acumulada pelo café, edificados no final do século XIX e início do século XX, constituindo importante acervo arquitetônico do ecletismo e da história do ciclo cafeeiro no estado de São Paulo. A abordagem teórica apóia-se especialmente em autores como Maria Cecília N. Homem; Nestor Goulart Reis Filho; Carlos L...

  17. Ciudad y riesgo: Un reto de seguridad ecológica urbana - Editorial

    Directory of Open Access Journals (Sweden)

    Andrea Lampis

    2010-06-01

    Full Text Available Las ciudades actuales pueden ser mejor comprendidas como un conjunto de sistemas o sub-sistemas en continua interacción entre sí. Este concepto, central en la perspectiva de la ecología urbana, nos permite encontrar una puerta de entrada interesante al problema planteado por este dossier: la interacción entre ciudad y riesgo. En la actualidad, el carácter de la generación del riesgo en las ciudades depende del continuo enfrentamiento a múltiples tipologías de amenazas y vulnerabilidades, así como a la multiplicación de las demandas para una mayor seguridad que, en su conjunto, representan verdaderos desafíos para su comprensión y manejo.

  18. DIREITO, PROPRIEDADE E REFORMAS URBANAS: RIO DE JANEIRO, 1903-1906

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    Pedro Jimenez Cantisano

    Full Text Available Resumo Este artigo se baseia na análise qualitativa de processos judiciais da primeira década do século XX - encontrados no Arquivo Nacional - para reconstruir o papel de práticas, instituições e conceitos jurídicos na resistência e adaptação dos proprietários do Rio de Janeiro às reformas urbanas de Pereira Passos e Rodrigues Alves. Como fontes complementares, são empregados anais parlamentares e legislação, para entender as bases legais das reformas; livros e revistas jurídicas, para estudar a evolução dos conceitos jurídicos relevantes, como o de "propriedade"; e jornais, para contextualizar e acessar aspectos extra-jurídicos dos litígios, ou seja, aquilo que não aparece nos autos processuais.

  19. El buen ciudadano: conocimiento social y saberes expertos en la convivencia urbana

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    José Hleap B.

    2006-10-01

    Full Text Available Este artículo examina las implicaciones (estigmatización, criminalización, exclusión, concentración de la inversión social en acciones punitivas o persuasivas que para ciertos sectores de la población se originan en los trabajos de investigación e intervención que sobre violencia y convivencia urbana se han adelantado en Cali (Colombia durante la última década, realizados “para su propio beneficio”, para brindarles “seguridad y bienestar”. Recrea la omisión del carácter de creación colectiva que tiene la convivencia en condiciones de precariedad, desigualdad y exclusión, que la hacen altamente conflictiva (la invisibilización de la labor solidaria, afectiva e imaginativa que se genera en la cotidianidad localizada.

  20. El buen ciudadano: conocimiento social y saberes expertos en la convivencia urbana

    Directory of Open Access Journals (Sweden)

    José Hleap B.

    2006-01-01

    Full Text Available Este artículo examina las implicaciones (estigmatización, criminalización, exclusión, concentración de la inversión social en acciones punitivas o persuasivas que para ciertos sectores de la población se originan en los trabajos de investigación e intervención que sobre violencia y convivencia urbana se han adelantado en Cali (Colombia durante la última década, realizados ¿para su propio beneficio¿, para brindarles ¿seguridad y bienestar¿. Recrea la omisión del carácter de creación colectiva que tiene la convivencia en condiciones de precariedad, desigualdad y exclusión, que la hacen altamente conflictiva (la invisibilización de la labor solidaria, afectiva e imaginativa que se genera en la cotidianidad localizada.

  1. “La Casa de las Flores”: arquitectura urbana-manifiesto de Secundino Zuazo /

    Directory of Open Access Journals (Sweden)

    Duarte, Patricio; Gurovich, Alberto; Pavez, M.Isabel.

    2007-06-01

    Full Text Available La "Casa de las Flores" es un interesante proyecto de arquitectura urbana residencial -bloques de departamentos de alquiler- del arquitecto bilbaíno Secundino Zuazo Ugalde (tit. 1912, m. en 1970. Realizado entre 1930 y 1932, es uno de los tres conjuntos más representativos del Movimiento Moderno en Madrid, y fue declarado Monumento Nacional en 1981. En uno de los pisos de este conjunto residió el Premio Nobel de literatura Pablo Neruda.This is a remarkably housing project -apartments for rent- of Secundino Suazo. The building –National Monument since 1981- is representative of the Modern Movement of Madrid as well as a fine example of urban architecture. Pablo Neruda, the Chilean Nobel Prize in Literature, was a resident there.

  2. A concordancia de numero no sintagma nominal na fala urbana de Rio Branco

    OpenAIRE

    Raimunda Coelho de Carvalho

    1997-01-01

    Resumo: Este trabalho trata da descrição e análise da concordância de número no sintagma nominal, tendo como amostra de fala a Língua Portuguesa da classe baixa da comunidade urbana de Rio Branco (Estado do Acre), sob a perspectiva da Sociolingüística Variacionista, aliada a alguns aspectos do Funcionalismo lingüístico. Após a fundamentação teórica, procedeu-se à descrição e à análise da variável lingüística Saliência fônica, subdividida em três dimensões: Processos morfofonológicos de formaç...

  3. Guadalajara: ¿en búsqueda de una nueva función urbana?

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    Fernando Pozos Ponce

    2004-01-01

    Full Text Available En este artículo se evalúan las principales transformaciones en la estructura económica de la zona metropolitana de Guadalajara (ZMG durante la década de los años noventa y se señalan las implicaciones que éstas tienen en la función urbana de esta metrópoli y en su centralidad en la región Centro-Occidente. Además, se señalan algunas implicaciones de la llegada de inversión extranjera directa en el espacio urbano de esta ciudad, en el sentido de la dependencia que esta metrópoli regional ha desarrollado ante las estrategias de expansión y competitividad de las grandes transnacionales de la industria electrónica y de telecomunicaciones.

  4. As questões habitacional e urbana na Venezuela contemporânea

    OpenAIRE

    Flávio Higuchi Hirao

    2015-01-01

    Essa dissertação aborda a questão urbana e habitacional na Venezuela. Realiza-se investigação histórica sobre os principais períodos da política habitacional na Venezuela a partir de 1928 (fundação do Banco Obrero), seguida pela caracterização do programa Gran Misión Vivienda Venezuela (sob a gestão de Hugo Chávez) e dos movimentos sociais urbanos reunido em torno da plataforma do Movimiento de Pobladoras y Pobladores. Investiga-se a importância da formação das favelas e a subsequente luta pe...

  5. Criminalidade violenta e fragmentação urbana na Grande Vitória

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    Cláudio Zanotelli

    2006-01-01

    Full Text Available Esse texto trata da análise e representa-ção de índices dos homicídios nos bairros das municipalidades da Aglomeração de Vitória no Espírito Santo. Partimos do pressuposto que os índices dos homicí-dios são mais elevados em alguns bairros com certo grau de segregação sócio-espacial. Configura-se assim uma organização espacial dos homicídios fundada na desigualdade sócio-econômica e em certos aspectos estruturais e conjunturais dessas zonas urbanas.

  6. A espera na vida urbana: uma análise psicossocial das filas

    OpenAIRE

    Iglesias, Fabio; Günther, Hartmut

    2009-01-01

    A fila de espera assume inúmeras funções na alocação dos recursos na vida urbana, como espaço, tempo, serviços e produtos. Suas configurações variam desde a típica fila presencial, aquelas em que as pessoas aguardam em pé umas atrás das outras, até formas implícitas de organização da espera, como aquelas geradas por tecnologias de comunicação remota providas pelo telefone e pela internet. Este artigo aborda a fila de espera como um sistema social, focando sua configuração presencial e destaca...

  7. Indias urbanas en el Buenos Aires tardocolonial. Familia y grupos domésticos

    Directory of Open Access Journals (Sweden)

    Jacqueline Sarmiento

    2011-11-01

    Full Text Available Nos proponemos analizar la integración de las indias a la vida urbana de Buenos Aires en el período colonial tardío. Este estudio se circunscribe al análisis de la conformación de los grupos domésticos. Consideramos que ellos son de una importancia fundamental ya que constituyeron los ámbitos en los cuales se transmitió y transformó el orden social. Para introducirnos a esta cuestión tomaremos en primera instancia los empadronamientos de la ciudad de Buenos Aires de los años 1744 y 1778. Dejamos para más adelante el abordaje de esta cuestión a partir de otras fuentes y con una escala de análisis reducida

  8. The Bolgary IX settlement – a site of the Ananyino finale in the vicinity of Perm

    Directory of Open Access Journals (Sweden)

    Vasilyeva Anastasia V.

    2015-06-01

    Full Text Available The article presents materials recovered from the Bolgary IX settlement, attributed to the late Ananyino group of sites, discovered in the vicinity of the city of Perm on the left bank of the Kama River. The structures thus found were interpreted by the authors as, presumably, a dwelling (? and a cult building. The pre-Ananyino cult buildings are well known by two hillforts – Zuevy Klychi-1 on the Lower Kama and Argyzh on the Vyatka River. Small clay figurines, arrow heads, spindle whorls, small oblational cups and household ceramics were found within the cult buildings. Household ceramics are represented by some typical late Ananyino vessel forms: mainly bowls with a closed throat, sometimes with profiled pronounced neck. Some vessels have a collar on the rim. Ornamentation of the vessels includes versatile corded, combed and recessed compositions. The Bolgary IX material culture is considered in complex with simultaneous Protasy burial ground, which is located on a nearby promontory and has similar ceramics among the grave goods. This complex of sites (the settlement and the burial ground is dated back to 3rd-2nd centuries BC and is related by the authors to the period of transition from the Ananyino to the Glyadenovo cultures in the Kama River region.

  9. Computational study of the solvation of protoporphyrin IX and its Fe2+ complex

    Science.gov (United States)

    Guizado, Teobaldo Cuya; Pita, Samuel Da Rocha; Louro, Sonia R. Wanderley; Pascutti, Pedro Geraldo

    Molecular dynamics (MD) simulations of a well known hydrophobic structure, the heme (ferroprotoporphyrin IX) and its precursor in the heme synthesis, protoporphyrin IX (PPIX) are presented. The objective of the present study is to determine the stability of both structures in an aqueous medium, as well as the structure-solvent relation, hydration shells, and discuss their implications for biological processes. The density functional theory (DFT) is used for the electronic and structural characterization of both PPIX and its Fe2+ complex. A classical approach based on the Gromacs package is used for the MD. The radial distribution function g(r) is used to examine the allocation of water molecules around different regions of the porphyrins. The calculations demonstrate the heterogeneous character of the porphyrins with respect to the affinity with water molecules, the general hydrophobic character of the porphyrin ring bonded or not to the ion Fe, the hydrophilic character of the carboxylic oxygen that is unchanged upon iron binding, and the low hydrophilicity of Fe2+ in the heme.

  10. Videografia Aérea Multiespectral em Silvicultura Urbana / Aerial Multiespectral Videography in Urban Forestry

    Directory of Open Access Journals (Sweden)

    Demóstenes Ferreira da Silva Filho

    2006-10-01

    Full Text Available Admitindo-se como hipótese básica a possibilidade do uso de imagens aéreas multiespectrais para classificação automática em classes de vegetação, objetivou-se, mediante comparações estatísticas entre dados de solo e videografia aérea multiespectral, avaliar a aplicação e uso de imagens multiespectrais de alta resolução para identificação, classificação e quantificação das estruturas urbanas, cobertura vegetal proporcionada pelas árvores. Após sobrevôo e mosaico, foram feitas análises estatísticas (teste t entre medidas de terrenos e ruas e as mesmas medições obtidas do mosaico corrigido. Foram feitas classificações automáticas supervisionadas com treinadores e auditores em alvos intra-urbanos da cidade de Piracicaba nas imagens de videografia. Foram obtidos resultados estatísticos para a videografia (Kappa acima de 80% e exatidão geral acima de 88% que demonstram a efetividade do mapeamento temático e viabilidade do uso da videografia para caracterização da estrutura intra-urbana em classificações supervisionadas. Foi avaliada a possibilidade de identificação de espécies arbóreas usando classificadores em imagem multiespectral com a possibilidade desse uso, principalmente quando existe uma ampliação da resolução temporal.

  11. Traumatismos maxilofaciais como marcadores de violencia urbana: uma analise comparativa entre generos

    Directory of Open Access Journals (Sweden)

    Carlos Jose de Paula Silva

    2014-01-01

    Full Text Available A violência tem sido um tema amplamente discutido em diversos setores da sociedade, quer pelo reflexo nos indicadores de segurança pública, pela influência no cotidiano dos indivíduos ou pela presença constante de vítimas nos serviços de saúde. O estudo avaliou comparativamente as diferenças de vitimização entre os gêneros a partir dos traumatismos maxilofaciais como marcadores de violência urbana. Trata-se de um estudo transversal com dados coletados em três hospitais especializados no atendimento a politraumatismos em Belo Horizonte (MG, entre janeiro de 2008 e dezembro de 2010. As análises envolveram estatística descritiva e multivariada por regressão logística. Identificou-se o registro de 7.063 vítimas, sendo 55,1% de violência interpessoal. A maioria das vítimas era do sexo masculino (71,2%. Nos homens, as agressões por arma de fogo, arma branca e acidentes motocilísticos foram as mais importantes quando comparadas às agressões nuas ou sem uso de armas. As fraturas múltiplas foram o tipo de traumatismo que melhor caracterizou o perfil de vitimização para o sexo masculino comparativamente às lesões de partes moles. O gênero é um importante fator na vitimização por traumatismo maxilofacial e violência urbana, sendo que os homens são as principais vítimas.

  12. Olas de calor e influencia urbana en Madrid y su área metropolitana

    Directory of Open Access Journals (Sweden)

    Fernández García, F.

    2008-12-01

    Full Text Available The frequency and duration of the warmest temperature episodes, a common phenomenon under the continental Mediterranean conditions of the Spanish Southern Meseta, has increased in the Madrid area since the 80´s, although their magnitude remains unchanged. The effect of the urban environment on those extreme events has exacerbated the heat load due to the persistence of the high temperatures along the night time hours. Nevertheless, the diversity of the urban morphology introduces a spatial variability on the strength of this nocturnal heat load, aggravating it in the densely urbanized areas and mitigating it in the vicinities of the green areas.

    La frecuencia y duración de los episodios cálidos extremos, un fenómeno habitual en el clima mediterráneo continental de la Meseta Meridional, ha aumentado en el área de Madrid desde los años noventa, aunque su magnitud permanece constante. En el interior de la aglomeración urbana, el efecto general de la ciudad sobre estos eventos climáticos extremos ha supuesto una exacerbación del calor, no tanto por un aumento de la temperatura máxima, como por una persistencia del calor en las horas nocturnas. No obstante, la diversidad de la morfología urbana introduce variaciones espaciales en la intensidad de este calor nocturno, agravando sus efectos en las áreas densamente urbanizadas y mitigándolos en las proximidades de las áreas verdes.

  13. Trasformazione urbana verso la mobilità dolce: il caso di Istanbul

    Directory of Open Access Journals (Sweden)

    Emilia Giovanna Trifiletti

    2008-12-01

    Full Text Available Nell’articolo si descrivono le recenti trasformazioni urbane della città di Istanbul in Turchia in relazione all’implementazione di aree pedonali e all’utilizzo di mobilità dolce. Il sistema trasportistico è stato ampliato ed integrato di recente ed in tempi molto brevi: nei soli ultimi due anni è stata potenziata la linea tranviaria, sono state inaugurate una funicolare ed una teleferica ed è stata realizzata una stazione di interscambio gomma-ferro, ponendo grande attenzione all’integrazione del trasporto su ferro e/o gomma con la mobilità pedonale. Allo stesso modo sono state implementate le linee marittime che collegano le diverse sponde della città ed integrate alle linee su ferro e su gomma. Lo sviluppo e la riqualificazione della città sono dunque stati guidati dalla trasformazione del sistema trasportistico che ha rappresentato il vero motore della riqualificazione urbana. L’antico quartiere di Sultanahmet è stato interamente riqualificato e collegato, attraverso la linea tranviaria veloce che lo attraversa interamente, al resto della città fino ai quartieri più periferici. Allo stesso modo nel quartiere di Beyoglu che, dopo l’indipendenza era caduto in totale rovina, ha riacquistato l’antica eleganza che lo connotava. Il viale dell’Indipendenza (antica Rue De Pera che attraversa tutto il quartiere è stato reso pedonale e con un tram vintage che percorre tutto il viale sono stati collegati il nodo di interscambio Taksim, dotato di metropolitana e funicolare, con il nodo di interscambio Tünel, dotato di tram veloce e trasporto su gomma. Nell’articolo si è inteso evidenziare come la riqualificazione urbana della città sia stata guidata da interventi integrati trasporto/territorio e come i risultati ottenuti, nel caso-studio, siano stati anche il frutto di politiche attente alla sicurezza sociale.

  14. Estructura urbana y policentrismo en el Área Metropolitana de Concepción

    Directory of Open Access Journals (Sweden)

    CAROLINA ALEJANDRA ROJAS QUEZADA

    2009-08-01

    Full Text Available Desde la perspectiva del modelo funcional se analiza la estructura urbana del Área Metropolitana de Concepción (Chile. Principalmente se identifican y caracterizan los centros urbanos que la conforman en función la población y la movilidad metropolitana; específicamente se aplican indicadores de empleo y funciones de densidad. Los resultados permitieron una aproximación al entendimiento de la organización jerárquica de los asentamientos y las centralidades; aclarando algunas tendencias de la estructura del modelo, ya sea del tipo mo-nocéntrico o policéntrico, tema en discusión si se refiere al análisis de las estructuras urbanas metropolitanas. Los aportes de la investigación apuntan a reflexionar sobre cómo se puede describir y caracterizar el comportamiento de la estructura funcional del modelo metropolitano por excelencia del sur del país.From the perspective of the functional model, the urban structure of the Metropolitan Area of Concepción (Chile is analyzed. The main objective is to identify and characterize the urban centers that comprise it as a result of the changes in the metropolitan population and its mobility, specifically with the use of employment indicators and density functions. The results approximate to an understanding of the hierarchical organization of the settlements and their centralities. This clarifies some of the patterns in the structure of the model, both monocentric andpolycentric, which is a point of debate in discussions of metropolitan urban structures. The contributions of the research point to ways of describing and characterizing the behavior of the functional structure of the leading example of a metropolitan model in the south of the country.

  15. La movilidad urbana sostenible y su incidencia en el desarrollo turístico

    Directory of Open Access Journals (Sweden)

    Heriberto Suárez Falcón

    2016-01-01

    Full Text Available La actividad turística ha experimentado un auge en las últimas décadas, presentando unas cifras que crecen de forma exponencial. En este sentido, puede considerarse una de las principales actividades económicas, básicamente por su capacidad de generar riqueza. Entre las tipologías más importantes del turismo, y probablemente la menos estudiada, se encuentra el turismo de ciudad o turismo urbano. Las ciudades concentran la actividad económica, política y social. Como resultado, han sido dotadas de espacios lúdicos que constituyen un patrimonio único. El desarrollo de políticas de movilidad sostenible puede promover la accesibilidad y el desplazamiento sencillo del turista mientras descubre los principales atractivos de la ciudad. Por ello es esencial la participación de la Administración Pública, convirtiéndose los Planes de Movilidad Urbana Sostenible (PMUS en el instrumento de planificación clave que integra los esfuerzos en esta dirección. En este trabajo se han analizado los PMUS de ocho ciudades españolas y latinoamericanas para verificar el grado de aplicación de medidas de movilidad sostenible importantes en el apoyo de la actividad turística urbana. Una de las principales conclusiones es que, aunque se aplican diferentes medidas para fomentar la movilidad sostenible, falta una referencia explícita al apoyo a la actividad turística en los planes consultados.

  16. Trabalho e Moradia na Periferia: para Uma Política Urbana Economicamente Orientada

    Directory of Open Access Journals (Sweden)

    Luciana Corrêa Lago

    2010-05-01

    Full Text Available

    O artigo examina as conexões entre as mudanças no mundo do
    trabalho e a qualidade de vida urbana na metrópole do Rio de Janeiro, buscando
    estender os sentidos do conceito de trabalho precário utilizado em
    análises estruturais de natureza estatística. A dimensão territorial, entendida
    como os lugares e as distâncias na cidade é incorporada como fator determinante
    de bem-estar social e como expressão e instrumento de poder econômico
    e simbólico. O texto conjuga uma leitura estrutural do mercado de
    trabalho metropolitano, privilegiando os municípios periféricos e os trabalhadores
    manuais, com a apreensão de algumas experiências de trabalho no
    setor de confecção de roupas, em bairros operários na periferia. A principal
    conclusão é de que a concentração territorial do setor de confecções e o saber
    acumulado pelas costureiras como trabalhadoras autônomas são dois
    elementos necessários para a ampliação de ações coletivas que disputem e
    redirecionem os recursos públicos para o fortalecimento de experiências autogestionárias
    de trabalho e para a reprodução do trabalhador e sua família.
    Palavras-chave: Território; trabalho precário; trabalho doméstico; autogestão;
    qualidade de vida urbana.

  17. IDENTIDAD URBANA Y EL TURISMO DE EVENTOS DEPORTIVOS: EL GRAND DEPART TOUR DE FRANCIA 2015

    Directory of Open Access Journals (Sweden)

    Juan Luis Paramio-Salcines

    2017-01-01

    Full Text Available Ciudades de todo tipo en la actual jerarquía urbana se afanan por adquirir una nueva identidad. En ese proceso de reinvención urbana, el turismo de eventos deportivos ha venido desarrollando una gran capacidad para generar diferentes impactos ‘tangibles’ e ‘intangibles’, como se argumenta en este artículo con el caso de la ciudad holandesa de Utrecht y la organización del Grand Depart Tour de Francia 2015 (GDTF. Si bien se ha analizado de manera amplia el uso estratégico del Tour de Francia por parte de numerosas ciudades en la última década desde la perspectiva de la oferta, este estudio exploratorio con un carácter marcadamente internacional que incluye nueve países, uno de los cuales es España, examina el GDTF 2015 desde la perspectiva de la demanda. En particular, estudia los factores clave que pueden facilitar o condicionar el deseo de viajar, previamente al propio evento, de ciudadanos españoles a Utrecht, para seguir dicho evento. Con el fin de valorar el grado de conocimiento de los principales atractivos de la ciudad, así como las principales motivaciones de estos ciudadanos españoles a la hora de viajar a Utrecht in situ, se han utilizado encuestas, un grupo de discusión y una revisión documental. El artículo concluye con los principales resultados que se derivan de las percepciones de los ciudadanos españoles de Utrecht y su relación con el GDTF 2015, además de las implicaciones prácticas de este caso.

  18. Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid-induced protoporphyrin IX for high-grade gliomas.

    Science.gov (United States)

    Yamamoto, Junkoh; Kakeda, Shingo; Yoneda, Tetsuya; Ogura, Shun-Ichiro; Shimajiri, Shohei; Tanaka, Tohru; Korogi, Yukunori; Nishizawa, Shigeru

    2017-03-01

    Magnetic resonance imaging (MRI) with a gadolinium-based contrast agent is the gold standard for high-grade gliomas (HGGs). The compound 5-aminolevulinic acid (5-ALA) undergoes a high rate of cellular uptake, particularly in cancer cells. In addition, fluorescence-guided resection with 5-ALA is widely used for imaging HGGs. 5-ALA is water soluble, while protoporphyrin IX (PpIX) is water insoluble. It was speculated whether converting from 5-ALA to PpIX may relatively increase intracellular water content, and consequently, might enhance the T2 signal intensity in HGG. The aim of the present study was to assess whether 5-ALA-induced PpIX enhances the T2 signal intensity in patients with HGGs. A total of 4 patients who were candidates for HGG surgical treatment were prospectively analyzed with preoperative MRI. Patients received oral doses of 5-ALA (20 mg/kg) 3 h prior to anesthesia. At 2.5 h post-5-ALA administration, T2-weighted images (T2WIs) were obtained from all patients. Subsequently, tumors were evaluated via fluorescence using a modified operating microscope. Fluorescent tumor tissues were obtained to analyze the accumulation of 5-ALA-induced PpIX within the tumors, which was confirmed quantitatively by high-performance liquid chromatography (HPLC) analysis. The MRI T2 signal intensity within the tumors was evaluated prior to and following 5-ALA administration. Three glioblastoma multiformes (GBMs) and 1 anaplastic oligodendroglioma (AO) were included in the analysis. Intraoperatively, all GBMs exhibited strong fluorescence of 5-ALA-induced PpIX, whilst no fluorescence was observed in the AO sample. HPLC analysis indicated a higher accumulation of 5-ALA-induced PpIX in the GBM samples compared with the AO sample. In total, 48 regions of interest were identified within the tumors from T2-WIs. In the GBM group, the relative T2 signal intensity value within the tumors following 5-ALA administration was significantly increased compared with the T2 signal

  19. Optical Observations of M81 Galaxy Group in Narrow Band [SII] and H_alpha Filters: Holmberg IX

    Directory of Open Access Journals (Sweden)

    Arbutina, B.

    2009-12-01

    Full Text Available We present observations of the nearby tidal dwarf galaxy Holmberg IX in M81 galaxy group in narrow band [SII] and H$alpha$ filters, carried out in March and November 2008 with the 2m RCC telescope at NAO Rozhen, Bulgaria. Our search for resident supernova remnants (identified as sources with enhanced [SII] emission relative to their H$alpha$ emission in this galaxy yielded no sources of this kind, besides M&H 10-11 or HoIX X-1. Nevertheless, we found a number of objects with significant H$alpha$ emission that probably represent uncatalogued HII regions.

  20. Broadband X-ray spectra of the ultraluminous x-ray source Holmberg IX X-1 observed with NuSTAR, XMM-Newton, and Suzaku

    DEFF Research Database (Denmark)

    Walton, D. J.; Harrison, F. A.; Grefenstette, B. W.

    2014-01-01

    We present results from the coordinated broadband X-ray observations of the extreme ultraluminous X-ray source Holmberg IX X-1 performed by NuSTAR, XMM-Newton, and Suzaku in late 2012. These observations provide the first high-quality spectra of Holmberg IX X-1 above 10 keV to date, extending the...

  1. Quantitative model calculation of the time-dependent protoporphyrin IX concentration in normal human epidermis after delivery of ALA by passive topical application or lontophoresis

    NARCIS (Netherlands)

    Star, Willem M.; Aalders, Maurice C. G.; Sac, Arnoldo; Sterenborg, Henricus J. C. M.

    2002-01-01

    We present a mathematical layer model to quantitatively calculate the diffusion of 5-aminolevulinic acid (ALA) in the skin in vivo, its uptake into the cells and its conversion to protoporphyrin IX (PpIX) and subsequently to heme. The model is a modification and extension of a recently presented

  2. LAS OSCILACIONES CLIMÁTICAS EN LA ATMOSFERA URBANA DE LA CIUDAD DE NATAL, BRASIL ATRAVÉS DE LAS SERIES LARGAS DE TEMPERATURAS DEL AIRE

    Directory of Open Access Journals (Sweden)

    Malco Jeiel de Oliveira Alexandre

    2013-10-01

    Full Text Available Este estudio tiene como objetivo el análisis de la isla de calor urbana (ICU y de la isla de frescor urbana (IFU en la ciudad de Natal (Brasil, mediante la comparación de las series largas de temperatura del aire máximas y mínimas diarias en dos estaciones meteorológicas convencionales representativas una en la área urbana y la otra en el entorno, durante el quinquenio 1995-2010. Los resultados muestran la presencia de de oscilaciones térmicas a partir del contraste entre las temperaturas del área urbana y su entorno y la caracterización de las islas de calor y frescor urbano en la ciudad de Natal.

  3. Agricultura urbana sostenibilidad y medios de vida experiencias en Ciudad Bolívar, Altos de Cazucá y Ciudadela Sucre

    OpenAIRE

    Cantor Marín, Kelly Marcela

    2009-01-01

    Motivada por vivencias en el sur de Bogotá y Soacha, en un contexto de precariedad y marginalidad, se investiga la agricultura urbana que realiza la población desplazada y vulnerable en estas zonas, analizando la incidencia de la agricultura urbana en la vida de estas personas y la sostenibilidad ambiental, económica, institucional y social de esta práctica en la ciudad.

  4. The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension.

    Science.gov (United States)

    Martin-Eauclaire, Marie-France; Salvatierra, Juan; Bosmans, Frank; Bougis, Pierre E

    2016-09-01

    We report the detailed chemical, immunological and pharmacological characterization of the α-toxin Bot IX from the Moroccan scorpion Buthus occitanus tunetanus venom. Bot IX, which consists of 70 amino acids, is a highly atypical toxin. It carries a unique N-terminal sequence extension and is highly lethal in mice. Voltage clamp recordings on oocytes expressing rat Nav1.2 or insect BgNav1 reveal that, similar to other α-like toxins, Bot IX inhibits fast inactivation of both variants. Moreover, Bot IX belongs to the same structural/immunological group as the α-like toxin Bot I. Remarkably, radioiodinated Bot IX competes efficiently with the classical α-toxin AaH II from Androctonus australis, and displays one of the highest affinities for Nav channels. © 2016 Federation of European Biochemical Societies.

  5. Comparison of the unitary pole and Adhikari-Sloan expansions in the three nucleon system

    International Nuclear Information System (INIS)

    Afnan, I.R.; Birrell, N.D.

    1977-01-01

    The binding energy of 3 H, percentage S-, S'- and D-state probability, and charge form factor of 3 He are calculated using the unitary pole and Adhikari-Sloan separable expansions to the Reid soft core potential. Comparison of the results for the two separable expansions show that the expansion of Adhikari and Sloan has the better convergence property, and the lowest rank expansion considered (equivalent to the unitary pole approximation) gives a good approximation to the binding energy of 3 H and the charge form factor of 3 He, even at large momentum transfer (K 2 -2 ). (Author)

  6. Investigation of the nucleon-nucleon tensor force in three-nucleon system

    Energy Technology Data Exchange (ETDEWEB)

    Clajus, M.; Egun, P.M.; Gruebler, W.; Hautle, P. (Eidgenoessische Technische Hochschule, Zurich (Switzerland). Inst. fuer Mittelenergiephysik); Slaus, I. (Institut Rudjer Boskovic, Zagreb (Yugoslavia)); Vuaridel, B. (Michigan Univ., Ann Arbor (USA) Brookhaven National Lab., Upton, NY (USA)); Sperisen, F. (Indiana Univ., Bloomington (USA). Cyclotron Facility); Kretschmer, W.; Rauscher, A.; Schuster, W.; Weidmann, R.; Haller, M. (Erlangen-Nuernberg Univ., Erlangen (Germany, F.R.)); Bruno, M.; Cannata, F.; D' Agostino, M. (Istituto Nazionale di Fisica Nucleare, Bologna (Italy)); Witala, H.; Cornelius, T.; Gloeckle, W. (Bochum Univ. (Germany, F.R.)); Schmelzbach, P.A. (Paul Scherrer Inst., Villigen (Switzerland))

    1990-08-16

    Proton-deuteron elastic scattering has been investigated at E{sub p}=22.7 MeV by comparison of rigorous Faddeev calculations with experimental results. The observable most sensitive to the tensor force is the nucleon-nucleon polarization transfer coefficient K{sub y}sup(y'). The new angular distribution of K{sub y}sup(y') clearly favours the tensor force of the Bonn A potential, which is weaker than the one of the Paris potential. (orig.).

  7. Investigation of effects beyond two-body forces in three-nucleon systems

    NARCIS (Netherlands)

    Ermisch, K.; van den Berg, A.M.; Bieber, R.; Hagemann, M.; Hannen, V.M.; Harakeh, M.N.; de Huu, M.A.; Kalantar-Nayestanaki, N.; Kis, M.; Micherdzilska, A.; Shafiei, M.; Wörtche, H.J.

    2001-01-01

    An experiment has been performed at KVI to measure vector analyzing powers and differential cross sections of the D((p) over right arrow pd) reaction as a function of incident beam energy. The measurements have been performed so far at several kinetic energies of the incoming particle between 108

  8. Recent results in the theory of the three-nucleon systems

    International Nuclear Information System (INIS)

    Friar, J.L.

    1987-06-01

    This paper concentrates on calculational results obtained by the Los Alamos-Iowa Faddeev group and on related calculations. Most of the interest of this group has centered on the Helium 3 and Hydrogen 3 ground states, including the effects of the Coulomb interactions between the two protons in Helium 3. Recent progress in treating the alpha particle is reported and zero energy n-d and p-d scattering and an improved understanding of the scattering lengths for these systems are also discussed. Simple physical pictures for these results are presented where possible. 54 refs., 9 figs

  9. Bag-model motivated NN potentials and the three-nucleon system

    International Nuclear Information System (INIS)

    Grach, I.L.; Narodetskij, I.M.

    1986-01-01

    Few examples are presented of the short-range energy-dependent NN potentials derived in the quark compound bag model which satisfy the classical causality condition and show that for the radii of the NN interactions b=1.35-1.40 fm these potentials reproduce the trinucleon binding energy

  10. The charge form factor of three-nucleon systems and the polarization of the bound nucleon

    International Nuclear Information System (INIS)

    Giannini, M.M.; Drechsel, D.; Arenhoevel, H.; Tornow, V.

    1979-01-01

    The discrepancy between theoretical calculations of the 3 He charge density and the results derived from elastic electron scattering may be due to the analysis of the experimental data in terms of spherical nucleons. A classical model with deformed nucleons gives qualitive agreement with experiment for an oblate quadrupole moment of -1.8 mb. Such a deformation of the bound nucleon can be described by the admixture of Δ(1232) and higher isobar components with spin >= 3/2. Since the admixture probabilities are small the dominant contributions stem from the transition quadrupole moments between free nucleon and isobar components. Taking into account the leading Δ(1232) components one can explain about half of the discrepancy. As this transition operator is isovector, the effects are opposite for 3 He and 3 H. (orig.)

  11. Efficacy of a high-purity factor IX concentrate in hemophilia B patients undergoing surgery Eficácia do concentrado de alta pureza do fator IX em pacientes cirúrgicos portadores de hemofilia B

    Directory of Open Access Journals (Sweden)

    Vesa Rasi

    2002-04-01

    Full Text Available A plasma derived, high purity, solvent-detergent treated and subsequently nanofiltered factor IX concentrate (BEMOFIL was evaluated in 19 hemophilia B patients, including four with severe, thirteen with mild or moderate type of disease and two hemophilia B carriers undergoing 31 surgical procedures. The mean in vivo recovery was 52 %, range 36 - 76 %. The mean preoperative plasma factor IX activity after the initial loading dose was 0.86 IU mL-1, range 0.59 - 1.32 IU mL-1. In eight major orthopedic procedures, the mean usage of factor IX was 44600 IU or 574 IU kg-1 during the hospital stay, mean 11.6 days. Thromboprophylaxis was not used. The hemostatic efficacy was evaluated good in all cases and there were no thromboembolic complications. In conclusion, BEMOFIL used as bolus dosing was found to be safe and effective in achieving hemostasis in subjects with hereditary F IX deficiency undergoing surgery.O concentrado de fator IX ( Bemofil , um derivado plasmático de alta pureza tratado com solventes- detergente e nano-filtrado , foi avaliado em 19 pacientes portadores de Hemofilia B .Quatro pacientes apresentavam a forma grave da moléstia, 13 a forma leve e moderada e dois portadores em um total de 31 atos cirúrgicos.A recuperação média "in vivo" foi de 52% (36-76%. A atividade plasmática média pré-operatória do fator IX após a dose inicial foi de 0,86 UI ml -1 , média de 0,59 - 1,32 UI ml-1. Em oito procedimentos ortopédicos extensos , a média de utilização do fator IX foi de 44.600 UI ou 574 UI kg -1 durante a hospitalização que teve a média de 11,6 dias. A tromboprofilaxia não foi utilizada. A eficácia hemostática avaliada em todos os casos foi boa ,e não ocorreu nenhum tipo de complicação tromboembólica. Concluímos que o Bemofil em bolus foi considerado seguro e eficaz para a hemostasia em pacientes portadores de hemofilia B que necessitam de um procedimento cirúrgico.

  12. Neutron-deuteron analyzing power data at En=22.5 MeV

    Science.gov (United States)

    Weisel, G. J.; Tornow, W.; Crowell, A. S.; Esterline, J. H.; Hale, G. M.; Howell, C. R.; O'Malley, P. D.; Tompkins, J. R.; Witała, H.

    2014-05-01

    We present measurements of n-d analyzing power, Ay(θ), at En=22.5 MeV. The experiment uses a shielded neutron source which produced polarized neutrons via the 2H(d⃗,n⃗)3He reaction. It also uses a deuterated liquid-scintillator center detector and six pairs of liquid-scintillator neutron side detectors. Elastic neutron scattering events are identified by using time-of-flight techniques and by setting a window in the center detector pulse-height spectrum. The beam polarization is monitored by using a high-pressure helium gas cell and an additional pair of liquid-scintillator side detectors. The n-d Ay(θ) data were corrected for finite-geometry and multiple-scattering effects using a Monte Carlo simulation of the experiment. The 22.5-MeV data demonstrate that the three-nucleon analyzing power puzzle also exists at this energy. They show a significant discrepancy with predictions of high-precision nucleon-nucleon potentials alone or combined with Tucscon-Melbourne or Urbana IX three-nucleon forces, as well as currently available effective-field theory based potentials of next-to-next-to-next-to-leading order.

  13. Antes y después del centro cultural: renovación urbana y desplazamiento en Bogotá

    Directory of Open Access Journals (Sweden)

    Diana Carolina Urbina Vanegas

    2015-01-01

    Full Text Available En el presente artículo, revisaré los efectos que han tenido las políticas de renovación urbana en el centro histórico de Bogotá, retomando la experiencia de los antiguos habitantes de la Manzana 5, ubicada en el barrio Las Aguas. En primer lugar, presenta - ré un análisis crítico del discurso en el que se posiciona la renovación urbana y del lu - gar estratégico que ocupa el deterioro del centro histórico. En la segunda parte, me acercaré a los residuos que deja a su paso un proceso de renovación que no contempla el factor social: las ruinas y el desplazamiento urbano, un fenómeno que se fundamenta en estrategias legítimas e ilegítimas de or - denamiento territorial.

  14. Ocupação Urbana de Rio das Ostras: Elementos Definidores e os Impactos nos Recursos Hídricos

    Directory of Open Access Journals (Sweden)

    Maria Laura Monnerat Gomes

    2010-11-01

    Full Text Available Na década de 1950, o território de Rio das Ostras começou a ser dividido em loteamentos, voltados principalmente para o turismo. A partir da década de 1990, ocorre o grande impulso demográfico para a região, principalmente devido à descoberta de petróleo na Bacia de Campos e a instalação da Petrobras em Macaé. A ocupação humana desordenada, sem planejamento e obediência às legislações ambiental e urbana, aliada à apropriação não sustentável dos recursos naturais, leva ao esgotamento dos ecossistemas naturais existentes. Este artigo aborda os elementos definidores da ocupação urbana e os impactos na bacia do rio das Ostras.

  15. Direitos civis dos jovens e a insegurança urbana Youth civil rights and urban insecurity

    Directory of Open Access Journals (Sweden)

    Augusto Caccia-Bava Junior

    2007-05-01

    Full Text Available Este ensaio parte do reconhecimento de uma conjuntura de crise institucional, para analisar o contexto da formação dos direitos civis dos jovens e suas fragilidades ,com vista a alcançar, por meio dessa reflexão, uma exposição dos aspectos da insegurança urbana presentes na sociedade brasileira. Palavras-chave: Crise institucional. Direitos civis dos jovens. Insegurança urbana. This essay starts with the recognition of a particular political institutional crisis as a base to analyze the development of the youth civil wrights and their gaps in order to reach an exposition of the characteristics of urban insecurity that takes place in Brazilian society. Keywords: Institutional crisis; Youth civil wrigths; Urban insecurity.

  16. La tierra urbana en el portafolio de las fortunas antioqueñas en la primera mitad del siglo XX

    Directory of Open Access Journals (Sweden)

    Fernando Botero

    1992-07-01

    Full Text Available La tesis principal, motivo de debate abierto que se plantea con este ensayo, tiene que ver con el papel que la tierra urbana tuvo en el conjunto de las fortunas antioqueñas. A su vez, esta temática sirve como puente para conectar los negocios a la historia urbana y ayudar a iluminar el debate en torno a la acumulación de capital en Antioquia. De esta forma la polémica sirve como pretexto y telón de fondo para exponer algunas tesis alternativas y proponer una nueva ventana para leer nuestro pasado y recuperar la memoria perdida que constituye el gran potencial y la esperanza para construir nuestro futuro.

  17. In silico evaluation of limited blood sampling strategies for individualized recombinant factor IX prophylaxis in hemophilia B patients

    NARCIS (Netherlands)

    Preijers, T.; Hazendonk, H. C. A. M.; Fijnvandraat, K.; Leebeek, F. W. G.; Cnossen, M. H.; Mathôt, R. A. A.

    2017-01-01

    Background Patients with severe hemophilia B regularly administer prophylactic intravenous doses of clotting factor IX concentrate to maintain a trough level of at least 0.01 IU mL(-1) in order to prevent joint bleeds. Assessment of individual pharmacokinetic (PK) parameters allows individualization

  18. PHKA2 mutation spectrum in Korean patients with glycogen storage disease type IX: prevalence of deletion mutations.

    Science.gov (United States)

    Choi, Rihwa; Park, Hyung-Doo; Kang, Ben; Choi, So Yoon; Ki, Chang-Seok; Lee, Soo-Youn; Kim, Jong-Won; Song, Junghan; Choe, Yon Ho

    2016-04-21

    Molecular diagnosis of glycogen storage diseases (GSDs) is important to enable accurate diagnoses and make appropriate therapeutic plans. The aim of this study was to evaluate the PHKA2 mutation spectrum in Korean patients with GSD type IX. Thirteen Korean patients were tested for PHKA2 mutations using direct sequencing and a multiplex polymerase chain reaction method. A comprehensive review of the literature on previously reported PHKA2 mutations in other ethnic populations was conducted for comparison. Among 13 patients tested, six unrelated male patients with GSD IX aged 2 to 6 years at the first diagnostic work-up for hepatomegaly with elevated aspartate transaminase (AST) and alanine transaminase (ALT) were found to have PHKA2 mutations. These patients had different PHKA2 mutations: five were known mutations (c.537 + 5G > A, c.884G > A [p.Arg295His], c.3210_3212delGAG [p.Arg1072del], exon 8 deletion, and exons 27-33 deletion) and one was a novel mutation (exons 18-33 deletion). Notably, the most common type of mutation was gross deletion, in contrast to other ethnic populations in which the most common mutation type was sequence variant. This study expands our knowledge of the PHKA2 mutation spectrum of GSD IX. Considering the PHKA2 mutation spectrum in Korean patients with GSD IX, molecular diagnostic methods for deletions should be conducted in conjunction with direct sequence analysis to enable accurate molecular diagnosis of this disease in the Korean population.

  19. Rifampicin-dependent antibodies bind a similar or identical epitope to glycoprotein IX-specific quinine-dependent antibodies

    NARCIS (Netherlands)

    Burgess, Janette K.; Lopez, Jose A.; Gaudry, Leonie E.; Chong, Beng H.

    2000-01-01

    The drug-dependent antibody of a patient with rifampicin-induced thrombocytopenia was characterized using the antigen-capture enzyme-linked immunosorbent assay (MAIPA assay), flow cytometry, and immunoprecipitation. The antibody was found to bind glycoprotein (GP) Ib-IX but not GPIIb-IIIa because

  20. Identification of genes encoding the type IX secretion system and secreted proteins in Flavobacterium columnare IA-S-4

    Science.gov (United States)

    Flavobacterium columnare, a member of the phylum Bacteroidetes, causes columnaris disease in wild and aquaculture-reared freshwater fish. The mechanisms responsible for columnaris disease are not known. Many members of the phylum Bacteroidetes use type IX secretion systems (T9SSs) to secrete enzymes...

  1. Egg-Citing! Isolation of Protoporphyrin IX from Brown Eggshells and Its Detection by Optical Spectroscopy and Chemiluminescence

    Science.gov (United States)

    Dean, Michelle L.; Miller, Tyson A.; Bruckner, Christian

    2011-01-01

    A simple and cost-effective laboratory experiment is described that extracts protoporphyrin IX from brown eggshells. The porphyrin is characterized by UV-vis and fluorescence spectroscopy. A chemiluminescence reaction (peroxyoxalate ester fragmentation) is performed that emits light in the UV region. When the porphyrin extract is added as a fluor…

  2. Gene therapy with adeno-associated virus vector 5-human factor IX in adults with hemophilia B

    DEFF Research Database (Denmark)

    Miesbach, Wolfgang; Meijer, Karina; Coppens, Michiel

    2018-01-01

    Hemophilia B gene therapy aims to ameliorate bleeding risk and provide endogenous factor IX (FIX) activity/synthesis through a single treatment, eliminating the requirement for FIX concentrate. AMT-060 combines an adeno-associated virus-5 (AAV5) vector with a liver-specific promoter driving expre...

  3. Comparison of adenovirus fiber, protein IX, and hexon capsomeres as scaffolds for vector purification and cell targeting

    International Nuclear Information System (INIS)

    Campos, Samuel K.; Barry, Michael A.

    2006-01-01

    The direct genetic modification of adenoviral capsid proteins with new ligands is an attractive means to confer targeted tropism to adenoviral vectors. Although several capsid proteins have been reported to tolerate the genetic fusion of foreign peptides and proteins, direct comparison of cell targeting efficiencies through the different capsomeres has been lacking. Likewise, direct comparison of with one or multiple ligands has not been performed due to a lack of capsid-compatible ligands available for retargeting. Here we utilize a panel of metabolically biotinylated Ad vectors to directly compare targeted transduction through the fiber, protein IX, and hexon capsomeres using a variety of biotinylated ligands including antibodies, transferrin, EGF, and cholera toxin B. These results clearly demonstrate that cell targeting with a variety of high affinity receptor-binding ligands is only effective when transduction is redirected through the fiber protein. In contrast, protein IX and hexon-mediated targeting by the same set of ligands failed to mediate robust vector targeting, perhaps due to aberrant trafficking at the cell surface or inside targeted cells. These data suggest that vector targeting by genetic incorporation of high affinity ligands will likely be most efficient through modification of the adenovirus fiber rather than the protein IX and hexon capsomeres. In contrast, single-step monomeric avidin affinity purification of Ad vectors using the metabolic biotinylation system is most effective through capsomeres like protein IX and hexon

  4. "Prompt and Equitable" Explained: How to Craft a Title IX Compliant Sexual Harassment Policy and Why It Matters

    Science.gov (United States)

    Block, Jason A.

    2012-01-01

    An April 2011 "Dear Colleague" letter issued by the U.S. Department of Education's Office for Civil Rights provided new guidance related to Title IX and the civil rights violation inherent in sexual harassment cases. Using the "Dear Colleague" letter as a guide, this article will provide best practice suggestions to remedy…

  5. Enhancing Title Ix Due Process Standards in Campus Sexual Assault Adjudication: Considering the Roles of Distributive, Procedural, and Restorative Justice

    Science.gov (United States)

    Harper, Shannon; Maskaly, Jon; Kirkner, Anne; Lorenz, Katherine

    2017-01-01

    Title IX prohibits sex discrimination--including sexual assault--in higher education. The Department of Education Office for Civil Rights' 2011 "Dear Colleague Letter" outlines recommendations for campus sexual assault adjudication allowing a variety of procedures that fail to protect accused students' due process rights and victims'…

  6. Up-Regulation of the Inflammatory Response by Ovariectomy in Collagen-Induced Arthritis. Effects of Tin Protoporphyrin IX.

    NARCIS (Netherlands)

    Ibanez, L.; Alcaraz, M.J.; Maicas Blasco, N.; Guede, D.; Caeiro, J.R.; Koenders, M.I.; Berg, W.B. van den; Ferrandiz, M.L.

    2011-01-01

    We have studied the influence of ovariectomy on the inflammatory response and bone metabolism on CIA as a model of postmenopausal arthritis as well as the effects of tin protoporphyrin IX (SnPP), a heme oxygenase inhibitor. Ovariectomy in non-arthritic mice produced increased serum PGD(2) levels and

  7. High overexpression of dye decolorizing peroxidase TfuDyP leads to the incorporation of heme precursor protoporphyrin IX

    NARCIS (Netherlands)

    Colpa, Dana I.; Fraaije, Marco W.

    2016-01-01

    Highlights • Dye decolorizing peroxidase TfuDyP binds heme and protoporphyrin IX in vivo. • The activity of TfuDyP is dependent on the expression level in E. coli. • Expression of fully functional DyPs can be tuned by the type of expression host and expression conditions. The heterologous

  8. A HIPÉRBOLE MERCANTIL DA EXPANSÃO URBANA E SUAS IMPLICAÇÕES AMBIENTAIS

    Directory of Open Access Journals (Sweden)

    Lucas Barbosa e Souzaz

    2015-01-01

    Full Text Available El contexto formado por el avance de la frontera agrícola en Brasil, por el consecuente y franco proceso de urbanización del território, además de la reciente política federal del gobierno acerca del sector de habi - tación, ha conllevado las grandes ciudades del Estado de Tocantins a presentar una la expansión urbana a menudo exagerada. La ciudad de Porto Nacional, a su vez, es un ejemplo notorio de este fenómeno. Dicha expansión urbana se ha basado en un carácter comercial excesiva, lo que conlleva a la división de la tierra, a través de los parcelamientos, que supera claramente la demanda local por viviendas nuevas. La compra deliberada de suelo urbanizado toma la forma de una práctica especulativa, lo que conlleva a formación de vacíos urbanos. Los principales actores involucrados en la implementación de estas parcelaciones adoptan estratégias capaces de maximizar la extracción de renta de la tierra en detrimento de criterios técnicos del orden urbano y ambiental. Con la ayuda de las ideas derivadas de la Geografía Humana y Geografía Física, este artículo pretende dar a conocer los vínculos entre este modelo de expansión urbana y los impactos ambientales relacionados. Entonces, son problematizadas la actual y las posibles consecuencias negativas para la calidad ambiental urbana, tomando la ciudad de Porto Nacional como referencia empírica.

  9. Procesos de ozonación fotocatalítica para eliminar contaminantes emergentes de aguas residuales urbanas

    OpenAIRE

    Espejo Morán, María Azahara

    2016-01-01

    En este trabajo se ha estudiado la degradación de distintos contaminantes emergentes (CEs) añadidos a un agua residual urbana mediante procesos químicos integrados secuencialmente como etapa previa o etapa terciaria a un tratamiento biológico aerobio convencional por fangos activos. Los compuestos seleccionados son acetaminofeno, antipirina, bisfenol A, cafeína, carbamazepina, diclofenaco, hidroclorotiazida, ketorolaco, metoprolol, sulfametoxazol y testosterona. Estos CEs se eligieron ya que ...

  10. Geografías urbanas: representación e identidad en la literatura africana en español

    Directory of Open Access Journals (Sweden)

    M’bare N’gom

    2012-12-01

    Full Text Available Este trabajo estudia las representaciones de las geografías urbanas y sus problemáticas en la literatura africana de expresión castellana. Para tal efecto propone la representación de las realidades urbanas como espacios de experiencias de vida heterogéneas, ya sean culturales, políticas o de renegociación de identidad. Igualmente examina cómo esa geografía urbana se configura como espacio que se presta a la articulación de una multitud de discursos y reinterpretaciones de la realidad urbana y urbanística, que obligan en este caso al sujeto migrante africano a embarcarse en un proceso de reterritorialización desde la transterritorialidad del desplazamiento, como estrategia de supervivencia en ese espacio ajeno y dislocado que es la ciudad.This study explores the representations of urban geography and its problematic in African literature in Spanish. It intends to examinate the representation of urban realities as spaces of heterogeneous experiences, be they cultural, political, or renegociation of identity. Along those lines, this study will discuss how urban geography becomes a space that allows a multitude of negociations, as well as the articulation of a variety of discourses and reinterpretations of urban and urbanistic reality that oblige the African migrant subject, in this case, to engage in a process of reterritorialization from the transterritoriality of displacement, as a strategy for survival in an alien and dislocated space such as the City.

  11. Estudio de los Efectos de la Morfología Urbana en la Actividad Física

    Directory of Open Access Journals (Sweden)

    Olta Braçe

    2016-07-01

    Full Text Available Un gran número de estudios, realizados principalmente en países anglosajones y del norte de Europa, han evaluado las posibles correlaciones existentes entre morfología urbana y la actividad física ligada a los desplazamientos (caminar y bicicleta. Los resultados de dichos estudios han puesto de manifiesto como las áreas urbanas de baja densidad, con usos de suelo segregados, escasez de servicios en proximidad, escasez de transporte público y espacios públicos de baja calidad reducen las probabilidades de desplazamientos relacionados con la actividad física (caminar y bicicleta y aumentan la dependencia del vehículo privado. En este artículo se comprueba cómo estos resultados son coherentes con los obtenidos en un estudio realizado en un área de la Europa mediterránea concretamente en el municipio de Mairena del Aljarafe. Con ello es posible afirmar que en nuestro entorno existe también relación entre la morfología urbana, la actividad física y el uso de modos de transporte relacionados con la actividad física (caminar y bicicleta. Estos resultados deberían servir para que los planificadores y gestores territoriales y urbanísticos tomasen medidas encaminadas a evitar el aumento de áreas urbanas dispersas y el fomento de núcleos de centralidad. Estas medidas ayudarían a reducir la dependencia del vehículo privado y fomentarían los desplazamientos no motorizados, permitiendo mantener los tres pilares del desarrollo sostenible (ambiental, económico y social.

  12. Pengaruh Pola Asuh Orang Tua Terhadap Agresivitas pada Persepsi Siswa Kelas IX

    Directory of Open Access Journals (Sweden)

    wening suko utami

    2017-10-01

    Full Text Available The purpose of this study was to determine how much the influence of the authoritarian, democratic, and permissive parenting to the aggressiveness of the students.In this study used a sample of students class IX in Kesatrian 2 Junior High School Semarang as many as 66 students of 228 students. The variables studied in this research were variable of parenting and aggressiveness. The data collection is done by using a questionnaire. Data were analyzed using descriptive analysis and multiple regression technique. The results of this multiple regression analysis is Y = 21.836 + 1.073 X1 + 0.393 X2 + 0.963 X3. There is a simultaneous contribution of 62.7%. There was effect of positive correlation parenting authoritarian, democratic and permissive to partially aggressiveness. The conclusion of this study, there was positive corelation foster parents towards aggressiveness simultaneously or partially.

  13. X-ray spectral line coincidences between fluorine VIII (and IX) and transition metal lines

    International Nuclear Information System (INIS)

    Charatis, G.; Rockett, P.D.; Burkhalter, P.G.

    1983-01-01

    X-ray spectroscopy was performed in the 12 to 15 A region, recording L-shell lines from selected laser-irradiated transition metals. Line coincidences and near coincidences were identified between Fe, Cr, Mn, and Ni L-spectra, and F VIII and F IX K-shell lines. Wavelengths were determined to accuracies of 1 to 3 mA and will be utilized in selecting potential pumping candidates in future x-ray lasing schemes. High-resolution x-ray spectra were collected under controlled illumination and target conditions using 1.05 μm and 0.527 μm laser excitation with the KMS CHROMA laser

  14. Simulation of an IXS imaging analyzer with an extended scattering source

    Energy Technology Data Exchange (ETDEWEB)

    Suvorov, Alexey [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II; Cai, Yong Q. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II

    2016-09-15

    A concept of an inelastic x-ray scattering (IXS) spectrograph with an imaging analyzer was proposed recently and discussed in a number of publications (see e.g. Ref.1). The imaging analyzer as proposed combines x-ray lenses with highly dispersive crystal optics. It allows conversion of the x-ray energy spectrum into a spatial image with very high energy resolution. However, the presented theoretical analysis of the spectrograph did not take into account details of the scattered radiation source, i.e. sample, and its impact on the spectrograph performance. Using numerical simulations we investigated the influence of the finite sample thickness, the scattering angle and the incident energy detuning on the analyzer image and the ultimate resolution.

  15. Formation of zinc protoporphyrin IX in Parma-like ham without nitrate or nitrite.

    Science.gov (United States)

    Wakamatsu, Jun-ichi; Uemura, Juichi; Odagiri, Hiroko; Okui, Jun; Hayashi, Nobutaka; Hioki, Shoji; Nishimura, Takanori; Hattori, Akihito

    2009-04-01

    Zinc protoporphyrin IX (ZPP) is a characteristic red pigment in meat products that are manufactured without the addition of a curing agent such as nitrate or nitrite. To examine the effects of impurities such as mineral components in sea salt on the formation of ZPP, we manufactured Parmatype dry-cured hams that were salted with refined salt or sea salt and examined the involvement of oxidation-reduction potential (ORP) in the formation of ZPP. The content of ZPP was increased drastically after 40 weeks. Microscopic observation showed strong fluorescence caused by ZPP muscle fiber after 40 weeks. Conversely, heme content varied considerably during processing. ORP increased during processing. However, there was no obvious difference between ham salted with refined salt and that salted with sea salt. Therefore, it was concluded that impurities in sea salt were not involved in the formation of ZPP.

  16. Infrared photometry of the nova-like system IX Velorum (= CPD -4801577)

    International Nuclear Information System (INIS)

    Haug, Karlheinz

    1988-01-01

    Continuous IR photometry of the UX UMa-type nova-like system IX Velorum reveals phase-correlated light variations in JHK filter bands with an amplitude of about O m .06. From a periodogram analysis an orbital period of P = 0.1939 ± 0.0001 day is determined. Physical reasons for the observed IR light variability are discussed. Model light curve calculations demonstrate that the observed light curves can be interpreted by a superposition of ellipsoidal light variations and asymmetric light distribution on the surface of the secondary component owing to illumination from the disc. The observation of different heights of the two light maxima might be an indication for an additional orbital light variation due to the changing aspect of the disc and/or bright spot region. (author)

  17. Proceedings of IX International Conference for Renewable Energy, Energy Saving and Energy Education (CIER 2017)

    International Nuclear Information System (INIS)

    2017-01-01

    The Study Centre for Renewable Energy Technologies (CETER) located at the Technological University of Havana Jose Antonio Echeverria (CUJAE) Cuba hosted the IX International Renewable Energy Conference, Energy Saving and Energy Education (CIER 2017). The current focus on Cuba's renewable energy sector is ambitious with the Government proposing to boost investment by USD 3.5 billion in order to reach its goal of generating 24 per cent of its power from renewable energy by 2030. CIER 2017 brought together hundreds of scientist, engineers, manufactures, investors, policy makers, energy users and other specialists from across the entire international renewable energy spectrum to exchange knowledge, debate and analyze the global efforts currently being carried out in the field. This is all with the objective of intensifying the introduction of renewable energy technologies and promoting the sustainable energetic development in Cuba and the Caribe.

  18. Campus Sexual Misconduct: Restorative Justice Approaches to Enhance Compliance With Title IX Guidance.

    Science.gov (United States)

    Koss, Mary P; Wilgus, Jay K; Williamsen, Kaaren M

    2014-07-01

    Campus response to sexual violence is increasingly governed by federal law and administrative guidance such as the 1972 Title IX, the 2011 Dear Colleague Letter (DCL), and the 2013 Violence Against Women Act. Educational institutions are directed to expand disciplinary responses and establish coordinated action to eliminate sexual violence and remedy its effects. Compliance fosters a quasi-criminal justice approach not suited to all sexual misconduct and inconsistent with developing practice in student conduct management. This article envisions restorative justice (RJ) enhancements to traditional student conduct processes that maintain compliance, expand options, empower victim choice, and increase responsiveness to DCL aims. The article (1) defines sexual violence and sexual harassment within the DCL scope, (2) elaborates the DCL position on permissible alternative resolutions and differentiates mediation from RJ, (3) sequences action steps from case report to finalization, including both restorative and traditional justice pathways; and (4) discusses building support for innovation beginning with existing campus response. © The Author(s) 2014.

  19. Prolactin-stimulated mitogenesis in the Nb2 rat lymphoma cell: Lack of protoporphyrin IX effects

    Energy Technology Data Exchange (ETDEWEB)

    Gerrish, K.E.; Putnam, C.W.; Laird, H.E. II (Univ. of Arizona, Tucson (USA))

    1990-01-01

    Pharmacological characterization of the Nb2 cell peripheral-type benzodiazepine receptor (PBR) was determined using selected 1,4-benzodiazepines, PK 11195, and protoporphyrin IX (PPIX) to compete for specific ({sup 3}H) Ro5-4864 binding. These data suggest that PPIX possesses an affinity for the Nb2 cell PBR. We have previously reported that the peripheral benzodiazepine ligands, Ro5-4864 and PK 11195, modulate prolactin-stimulated mitogenesis in the Nb2 cell. In contrast, PPIX, a putative endogenous ligand for the PBR had no effect on prolactin-stimulated mitogenesis in the Nb2 cell over the concentration range from 10{sup {minus}15} M to 10{sup {minus}6} M. Taken together these data show that PPIX has an affinity for the Nb2 cell PBR but does not modulate prolactin-stimulated mitogenesis at concentrations which should bind to the Nb2 cell PBR.

  20. 5. IX avati Pärnus paralleelselt Eesti Litograafiakeskuse korraldatud litograafiasümpoosioniga...

    Index Scriptorium Estoniae

    2003-01-01

    Litograafiakeskuses litograafia ajalugu tutvustav näitus. Pärnu kontserdimajas noorte - Jaak Visnap, Inga Heamägi, Kadri Alesmaa, Marko Mäetamm, Viljar Kõiv, Lembe Ruben - litograafianäitus "New generation". Endla teatri näitusesaalides näitus "Old Stars" - esinevad Evi Tihemets, Marje Üksine, Raul Meel, Leonhard Lapin, Tiia Külv, Urmas Vaino, Herald Eelma. Teatri Küüni ja kohviku seintel noorte soome ja rootsi litograafide tööd. Pärnu mudaravilas ülevaade litokeskuse kursustel valminud töödest. Endises Linnagaleriis Rüütli t. näitus 6.-12. IX sümpoosioni raames toimunud workshop'ide töödest

  1. Indicadores de tercera generación para cuantificar la sustentabilidad urbana: ¿Avances o estancamiento?

    Directory of Open Access Journals (Sweden)

    Silvia León A

    2013-09-01

    Full Text Available Las intrincadas relaciones que caracterizan el metabolismo de las zonas urbanas precisan ser visualizadas mediante fórmulas simplificadas, capaces de respaldar la toma de decisiones en favor de la sustentabilidad urbana. En el marco teórico ordenador de la Coevolución (Norgaard, 1984, y el cálculo del Análisis de Flujo de Materiales (AFM y de la Huella Ecológica Local (HEL para la Región Metropolitana de Santiago (Chile y la ciudad-región de Bogotá (Colombia, se muestra dicha dupla (AFM y HEL como indicadores de tercera generación - vinculantes, locales, sinérgicos y transversales- que incorporan simultáneamente diversas variables con amplias categorías y dimensiones, además de un alto grado de aporte (el 80% a la cuantificación de la sustentabilidad urbana. El posicionamiento de lo local, por medio de la huella ecológica local, también prevalece en el mejoramiento de los indicadores relativos a la sustentabilidad de una urbe específica, por encima de la estandarización de las metodologías basadas en comparaciones o rankings internacionales.

  2. movilidades urbanas y experiencias del espacio público en la Bogotá contemporánea

    Directory of Open Access Journals (Sweden)

    Óscar Iván Salazar Arenas

    2013-01-01

    Full Text Available Hasta hace poco, en la mayoría de trabajos sobre el espacio público había primado el análisis de los lugares, los peatones y la ciudadanía. Muchos de ellos habían descuidado e incluso satanizado los flujos de personas, objetos e información, así como el uso del automóvil, dentro de una concepción dual que privilegiaba el “humanismo cívico”. Esta reflexión hace parte de las recientes críticas a esas miradas y discute el concepto de experiencia urbana en su relación con una ecología urbana dinámica, móvil y transhumana. El argumento explora críticamente la metáfora de la tortuga y la liebre como herramienta interpretativa en el análisis cultural de las movilidades y su papel integrador en las prácticas cotidianas, la materialidad de la ciudad y la cultura urbana.

  3. In vitro evaluation of photodynamic therapy using redox-responsive nanoparticles carrying PpIX

    Science.gov (United States)

    Souza Leite, Ilaiáli; Vivero-Escoto, Juan L.; Lyles, Zachary; Salvador Bagnato, Vanderlei; Mayumi Inada, Natalia

    2018-02-01

    Photodynamic therapy (PDT) is a technique that combines light's interaction with a photoactive substance to promote cellular death and that has been used to treat a wide range of maladies. Cancer is among the leading causes of death worldwide and has been a central issue assessed by PDT research and clinical trials over the last 35 years, but its efficiency has been hampered by photosensitizer buildup at treatment site. Nanotechnology has been addressing drug delivery problems by the development of distinct nanostructured platforms capable of increasing pharmacological properties of molecules. The association of nanotechnology's potential to enhance photosensitizer delivery to target tissues with PDT's oxidative damage to induce cell death has been rising as a prospect to optimize cancer treatment. In this study, we aim to verify and compare the efficiency of PDT using redox-responsive silica-based nanoparticles carrying protoporphyrin IX (PpIX) in vitro, in both tumor and healthy cells. Dose-response experiments revealed the higher susceptibility of murine melanoma cells (B16-F10 cell line) to PDT (630 nm, 50 J/cm2) when compared to human dermal fibroblasts (HDFn): after 24 h of incubation with 50 μg/mL nanoparticles solutions, approximately 80 % of B16- F10 cells were killed, while similar results were obtained in HDFn cultures when solutions over 150 μg/mL were used. Uptake and ROS generation assays suggest increased nanoparticle internalization in the tumor cell line, in comparison with the healthy cells, and greater ROS levels were observed in B16-F10 cells.

  4. Seth Nicholson's First Satellite Discovery: Jupiter IX and His Orbit for It

    Science.gov (United States)

    Osterbrock, Donald E.

    2006-12-01

    Seth B. Nicholson was a graduate astronomy student at the University of California in Berkeley when he discovered his first satellite in 1914. He was later to discover three more, after he had joined the Mount Wilson Observatory staff following his PhD in 1915. Nicholson had begun his thesis on the problem of computing an improved orbit for J VIII, which had been discovered by Melotte in England in 1908, a distant irregular satellite like J VI and J VII. Nicholson was taking photographic plates to measure the position of J VIII in the summer of 1914 with the Crossley 36-inch reflector of Lick Observatory. He was a teaching assistant at Berkeley that summer, but would go up to Mount Hamilton to observe on weekends in the dark of the moon, traveling by rail, stage (an automobile on a regular schedule between San Jose and the observatory) and interurban trolley car, and sleeping in a shed near the Crossley dome. He first saw J IX as a much fainter object with the same motion as J VIII on a plate he took in late July 1914, and realized it must be another satellite of the giant planet. Nicholson obtained his first orbit of J IX, which had by then become his new thesis topic, in September, and published a paper on it in early 1915. Its orbit, like that of J VIII, was retrograde and irregular, but it was considerably fainter. Nicholson, a loyal student of Armin O. Leuschner, the head of the Berkeley Astronomy Division, used his teacher's "short method" (or analytic method) to calculate the orbit.

  5. Pengembangan Soal Penalaran Model TIMSS Konteks Sumatera Selatan di Kelas IX SMP

    Directory of Open Access Journals (Sweden)

    Hazlita Hazlita

    2015-10-01

    Full Text Available AbstrakPenelitian ini bertujuan untuk menghasilkan soal-soal penalaran model TIMSS konteks Sumatera Selatan yang valid dan praktis dan untuk melihat efek potensial soal matematika tipe TIMSS konteks Sumatera Selatan terhadap kemampuan penalaran matematis siswa. Subjek penelitian adalah siswa kelas IX SMPN 9 Palembang yang berjumlah 29 orang. Metode penelitian adalah penelitian pengembangan. Hasil penelitian menunjukkan bahwa sebanyak 37,93% siswa menunjukkan tingkat kemampuan penalaran matematis yang baik. Sebanyak 55,17% siswa menunjukkan tingkat kemampuan penalaran matematis yang cukup dan sebanyak 6,90% siswa menunjukkan tingkat kemampuan penalaran matematis yang kurang. Berdasarkan hasil tes tersebut, jika nilai rata-rata siswa siswa sebesar 39,24 dijadikan sebagai batas acuan, maka bisa disimpulkan bahwa 31,03% siswa memiliki kemampuan penalaran matematis yang kurang, sementara 68,97% siswa sudah memiliki kemampuan pelanaran matematis yang cukup baik. Kata Kunci: Soal Penalaran; TIMSS; Konteks Sumatera Selatan  AbstractThe aim of this research was developing valid and practical TIMSS reasoning problem on mathematics context of South Sumatra. The subjects of this research were 29 students of class IX SMPN 9 Palembang. The method of research is the development of research. The results showed that 37.93% of students showed levels of good mathematical reasoning abilities, 55.17% of students showed levels sufficient mathematical reasoning ability and 6.90% of students showed levels of mathematical reasoning abilities are lacking. Based on the test results, if the 39.24 was determined as minimum limit of success, it means that 31.03% of students have less mathematical reasoning ability, while 68.97% of students already have sufficient mathematical reasoning ability. Keywords: Problem Reasoning; TIMSS; Context South Sumatra

  6. Mobilità Urbana Sostenibile: strategie attuali e nuove sfide per le città europee

    Directory of Open Access Journals (Sweden)

    Adriana Galderisi

    2011-07-01

    Full Text Available Nel decennio 2001-2010 numerosi passi sono stati compiuti dall’Unione Europea per orientare le città europee verso forme di mobilità sostenibile. Finalità comune alle numerose iniziative messe in campo dall’UE è stata quella di promuovere, soprattutto nelle aree urbane, un aumento della mobilità – indispensabile per lo sviluppo competitivo delle città e per garantire ai cittadini elevate opportunità di accesso alle dotazioni urbane – e una contemporanea drastica riduzione dei significativi costi ambientali che ad essa risultano, a tutt’oggi, associati.Strategie, iniziative e ricerche in ambito europeo sono state orientate, nel corso del decennio 2001-2010, a promuovere una sostanziale limitazione del trasporto individuale su gomma all’interno delle aree urbane e ad incentivare forme di mobilità sostenibile. Più specificamente, strategie e azioni sono state prioritariamente rivolte a: favorire innovazioni relative ai modi e ai mezzi del trasporto urbano; garantire un riequilibrio intermodale all’interno delle aree urbane, favorendo il trasporto pubblico, soprattutto su ferro, e gli spostamenti pedonali e ciclabili; superare la settorialità che ha a lungo caratterizzato la pianificazione dei trasporti, delineando processi di governo basati sull’integrazione tra politiche e strumenti per la pianificazione della città, dei trasporti e dell’ambiente (Galderisi, 2007. A partire dal 2007, l’Unione Europea ha ulteriormente e significativamente intensificato il proprio impegno per una riduzione dei costi ambientali della mobilità urbana: dal Libro Verde sul Trasporto Urbano, al Patto dei Sindaci mirato a coinvolgere attivamente le città europee nel percorso verso la sostenibilità energetica ed ambientale e, ancora, al più recente Libro Bianco sui Trasporti del 2011, numerose sono state le iniziative messe in campo dall’Unione Europea per dare concretezza e operatività agli indirizzi già delineati nel Libro Bianco

  7. Activation of 125I-Factor IX and 125I-Factor X: Effect of tissue factor and Factor VII, Factor Xsub(a) and thrombin

    International Nuclear Information System (INIS)

    Oesterud, B.; Rapaport, S.I.

    Activation of Factor IX and Factor X was studied by adding 125 I-Factor IX or 125 I-Factor X to reaction mixtures and quantitating cleavage products by reduced sodium dodecylsulfate gel electrophoresis. Thrombin failed to activate Factors IX or X; Factor Xsub(a) produced insignificant amounts of cleavage products of both factors. In contrast, the reaction product of tissue factor and Factor VII cleaved large amounts of both Factor IX and Factor X in purified systems and in plasma. In incubation mixtures of plasma containing added 125 I-Factor IX or 125 I-Factor X, tissue factor and Ca 2+ ions, the percentage of total radioactivity in the heavy chain peak of 125 I-IXsub(a) and the heavy chain of 125 I-Xsub(a) increased at a similar rate. When the tissue factor was diluted, similar curves were obtained for percent cleavage of 125 I-Factor IX and percent cleavage of 125 I-Factor X plotted against tissue factor concentration. These findings support the hypothesis that activation of Factor IX by the tissue factor-Factor VII reaction product represents a physiologically significant step in normal haemostasis. (author)

  8. Encuesta nacional sobre violencia intra-familiar, Costa Rica urbana, 1992

    Directory of Open Access Journals (Sweden)

    Leonardo Mata

    2010-01-01

    Full Text Available Esta es la primera encuesta sobre violencia doméstica que se concreta en la población general urbana de que se tiene noticia en América Central. La Bibliografía que acompaña el presente estudio muestra otros intentos sobre el tema, que desafortunadamente tienen diseños o planteamientos que no son imparciales en abordar el tema. En efecto, el abordaje del tema demanda imparcialidad total con referencia al género, como es el caso del presente estudio. Se seleccionaron aleatoriamente, en población general urbana definida por el Instituto Nacional de Estadística y Censo (INEC, y usando sus Tractos Censales y Mapas, 750 mujeres y 750 hombres de 18 a 60 años de edad, de centros urbanos del país. El diseño demandó que las personas entrevistadas no pudieran conocerse, y de que las entrevistas evitaron sesgos y prejuicios. Muy importante fue el que las preguntas se orientaran tanto a establecer si la mujer y el hombre recibieran agresión de sus parejas, como a establecer que esas mismas ejercían agresión contra sus parejas también. Las agresiones se limitaron a establecer el grado o nivel de tranquilidad dentro del hogar, los tipos de violencia (insultos, amenazas, violencia física, etc., excluyéndose al homicidio, por razones obvias. También se trató de cuantificar esas agresiones. Lo más pertinente de la encuesta fue el establecer el testimonio de agresor o de víctima en cada persona, fuese mujer u hombre. El principal hallazgo del estudio fue determinar que tanto las mujeres como los hombres fueron similarmente víctimas de sus parejas; y que tanto las mujeres como los hombres también similarmente agresores contra sus parejas. Sin embargo, los hombres mostraron un mayor grado del uso de palabras y expresiones ofensivas que sus mujeres.

  9. Encuesta nacional sobre violencia intra-familiar, Costa Rica urbana, 1992

    Directory of Open Access Journals (Sweden)

    Leonardo Mata

    2010-07-01

    Full Text Available Esta es la primera encuesta sobre violencia doméstica que se concreta en la población general urbana de que se tiene noticia en América Central. La Bibliografía que acompaña el presente estudio muestra otros intentos sobre el tema, que desafortunadamente tienen diseños o planteamientos que no son imparciales en abordar el tema. En efecto, el abordaje del tema demanda imparcialidad total con referencia al género, como es el caso del presente estudio. Se seleccionaron aleatoriamente, en población general urbana definida por el Instituto Nacional de Estadística y Censo (INEC, y usando sus Tractos Censales y Mapas, 750 mujeres y 750 hombres de 18 a 60 años de edad, de centros urbanos del país. El diseño demandó que las personas entrevistadas no pudieran conocerse, y de que las entrevistas evitaron sesgos y prejuicios. Muy importante fue el que las preguntas se orientaran tanto a establecer si la mujer y el hombre recibieran agresión de sus parejas, como a establecer que esas mismas ejercían agresión contra sus parejas también. Las agresiones se limitaron a establecer el grado o nivel de tranquilidad dentro del hogar, los tipos de violencia (insultos, amenazas, violencia física, etc., excluyéndose al homicidio, por razones obvias. También se trató de cuantificar esas agresiones. Lo más pertinente de la encuesta fue el establecer el testimonio de agresor o de víctima en cada persona, fuese mujer u hombre. El principal hallazgo del estudio fue determinar que tanto las mujeres como los hombres fueron similarmente víctimas de sus parejas; y que tanto las mujeres como los hombres también similarmente agresores contra sus parejas. Sin embargo, los hombres mostraron un mayor grado del uso de palabras y expresiones ofensivas que sus mujeres.

  10. Violência urbana: um problema social Urban violence: a social problem

    Directory of Open Access Journals (Sweden)

    Álvaro de Aquino e Silva Gullo

    1998-05-01

    Full Text Available O presente artigo reúne um conjunto de reflexões sobre diversos aspectos em que se manifesta a violência social. Essas reflexões, apresentadas em momentos diferentes, como aulas, debates e num congresso, foram agrupadas sob o título de Violência Urbana porque concorrem para a compreensão da violência cotidiana enquanto problema da sociedade urbana. Dos cursos regulares, registro a concepção inicial, tomada da antropologia social, que leva à caracterização da violência na sociedade rural para fundamentar a gênese do problema na sociedade contemporânea de classes sociais, focalizado na perspectiva da marginalidade estrutural. Dos debates sucitados por acontecimentos traumáticos envolvendo o aparato policial, resultou uma discussão sobre as causas da violência inerente ao desempenho da função institucional atribuída às polícias militar e civil. Da participação em congresso sobre o novo Código de Trânsito Brasileiro, resultou a parte final deste artigo que discute o papel e, particularmente, o significado dos símbolos sociais divulgados pelos meios de comunicação de massa, como fatores responsáveis pela crescente violência no trânsito.This article contains some reflections on how social violence expresses itself. These reflections, presented in former moments as lectures, public debates and at a congress, have been gathered under the title of Urban Violence because they all try to comprehend everyday violence as a problem of urban society. Based on the lectures I have formulated the first part of this article, which deals with a conception taken from social anthropology: the characterization of violence in rural society under the perspective of structural marginality, in order to explain the genesis of this problem in the actual social class society. The debates, that took place because of traumatic happenings related to the police apparatus, have brought about a discussion of the causes of violence inherent to the

  11. Utilização de antimicrobianos em uma população urbana

    Directory of Open Access Journals (Sweden)

    Laura S Berquó

    2004-04-01

    Full Text Available OBJETIVO: A emergência de cepas microbianas com crescentes níveis de resistência aos antimicrobianos tem sido objeto de preocupação em todo o mundo. Entre as causas apontadas para o fenômeno, está o uso abusivo e indiscriminado de drogas antimicrobianas. O presente estudo visa fornecer informações sobre o padrão de utilização dessas drogas em uma população urbana. MÉTODOS: Em um estudo transversal, de base populacional, 6.145 indivíduos de todas as idades residentes na zona urbana de Pelotas, Rio Grande do Sul, foram entrevistados sobre o uso de antimicrobianos nos 30 dias que antecederam a entrevista. RESULTADOS: A prevalência global de utilização de antimicrobianos encontrada foi de 8%. Essa foi maior entre as crianças até quatro anos de idade (14%; p<0,001, entre as mulheres (9%; p=0,004 e entre os separados/divorciados (10%; p=0,02. As indicações clínicas principais foram infecções do trato respiratório (50%, infecções do trato urinário (16% e infecções dentárias (9%. As drogas antimicrobianas mais utilizadas foram as penicilinas (41%, as sulfas (17% e as tetraciclinas (8%. CONCLUSÕES: O uso intensivo de drogas de última geração, temido por muitos estudiosos do tema, não foi confirmado. A possibilidade de redução da utilização de antimicrobianos existe, uma vez que as afecções do trato respiratório (a principal indicação para o seu uso são, em sua maioria, de etiologia viral, e seu tratamento não se beneficia com drogas antimicrobianas.

  12. DINÂMICA URBANA DE ESPAÇOS EM CRISE: PORTO PRÍNCIPE/ HAITI

    Directory of Open Access Journals (Sweden)

    Adriano Bittencourt Andrade

    2016-01-01

    Full Text Available Este artículo aborda las diversas facetas de la crisis que se materializó en el espacio urbano. El texto de este artículo, a la luz de las dinámicas que rigen el espacio geográfico, se centra en las crisis urbanas y echa un vistazo al caso focal de Haití, evaluar el impacto de las crisis que se cruzan (crisis política, los conflictos armados, la intervención externa, los desastres naturales repentinos - terremotos y huracanes - entre otros en el área urbana de Puerto Príncipe, la capital. Para la producción de este artículo, la investigación se ha desarrollado en dos frentes: se recurrió a las fuentes bibliográficas sobre Haití y su propio enfoque temático; y hubo entrevistas directas con los soldados que tomaron parte, en representación del Ejército de Brasil, la Misión de Mantenimiento de la Paz de la ONU en Haití. Este artículo análisis la relación entre la producción de material de espacio y su ocupación y uso social de proporcionar elementos para comprender la profunda fragmentación que hay en la ciudad generando un absolutamente dicotómicas dinámica interna entre una élite y la gran población que vive en los espacios de excepción. En lugar de presentar una gran cantidad de información y datos sobre el empobrecido país antillano, en este artículo, a partir de una realidad concreta, lanza “flechas” de interpretaciones sostenidas en el análisis de la configuración territorial y por lo tanto estimula el debate, más allá de la perspectiva local tiende a reflejarse en muchos otros lugares del mundo.

  13. Kinetic study of the substitution of pyridine by cyanide in the bis(pyridine)cobalt(III)hematoporphyrin-IX: distinguishing between Isub(d) and D mechanism

    International Nuclear Information System (INIS)

    Birush, M.; Pribanicj, M.

    1977-01-01

    ''Mass-law (rate) retardation'' effect shows that the reaction between the cyanide ion and bis(pyridine)cobalt(III)hematoporphyrin-IX complex to give (CN) 2 cobalt(III)hematoporphyrin-IX occurs by a purely dissociative (D but not Isub(d)) mechanism in chloroform. Limiting rate constant at the excess of cyanide ion concentration at 25 deg C was found to be 2.5x10 -3 S -1 and the competition ratio of pyridine (ksub(-) 1 ) and the cyanide ion (k 2 ) for a five coordinate intermediate (pyridin) cobalt(III)hematoporphyrin-IX complex was obtained as ksub(-) 1 /k 2 =0.35. (author)

  14. Arquetipos de una identidad urbana. Cafés y bares montevideanos (1900 a 1960

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    Arq. Laura Fernandez Quinteiro

    2011-11-01

    Full Text Available La investigación versa sobre un conjunto de obras que no han sido realizadas por arquitectos, ni cuentan con legitimación académica. La hipótesis: la presencia del café y bar en la cultura europea se trasladó a Montevideo como la expresión de un correlato en el que se detectan constantes en las pautas compositivas y en las categorías formales y sensibles. Dichas invariantes inducen al reconocimiento de elementos arquetípicos que hacen a la esencia del programa, en estrecho vínculo con un modelo de ciudad y signando una identidad urbana. El método se basó fundamentalmente en la herramienta elegida para el estudio de casos: el dibujo como forma de pensar la arquitectura. En las conclusiones se reflexiona sobre el rol que cumplieron los cafés y bares en la ciudad, como motores dentro de las reglas de juego del urbanismo no planificado por especialistas. Actualmente, la ciudad se ha dejado de articular por los mismos, inexorablemente las megaestructuras (shoppings e hipermercados se arraigaron y multiplicaron, “succionando” a todo competidor. Son consecuencia de junkspace –término acuñado por Koolhaas–, que impuso cambios conceptuales en la arquitectura con la aplicación de un modelo único y globalizador que determinó que todas las ciudades se parecieran entre sí.

  15. Uma proposta prática de aprendizado para a disciplina de geologia urbana

    Directory of Open Access Journals (Sweden)

    Sueli Yoshinaga Pereira

    2015-06-01

    Full Text Available Este trabalho apresenta uma proposta de aprendizado aplicada na disciplina de Geologia Urbana oferecida pelo curso de Geologia da Universidade Estadual de Campinas (UNICAMP aos estudantes do 5° ano, com ênfase para os trabalhos de campo. Pelo tipo de abordagem adotado ao longo do semestre, a disciplina visa despertar nos estudantes uma consciência crítica da futura profissão de geólogo e qual a sua função social. Para cada tema do programa foi montada uma aula teórica, seguida de visita de campo e finalizada com uma oficina. A experiência de três anos indica que parcela significativa dos alunos compreende a proposta e a importância de sua participação, mas há um grupo que permanece passivo e desenvolve atitude cartorial diante do ensino. Embora a inovação tenha sido testada somente três vezes, envolvendo pouco menos de 80 alunos, assinalamos que os resultados foram satisfatórios

  16. EVALUACIÓN DE REQUERIMIENTOS NUTRICIONALES EN VIVERO DE ESPECIES TROPICALES EMPLEADAS EN SILVICULTURA URBANA

    Directory of Open Access Journals (Sweden)

    David Andrés Herrera Ramírez

    Full Text Available La fertilización es determinante del crecimiento y desarrollo de árboles urbanos. Por ello, estudiamos, mediante la técnica del elemento faltante, los requerimientos nutricionales de cinco especies tropicales usadas en silvicultura urbana (Tabebuia chrysantha, Margaritaria nobilis, Hamelia patens, Apeiba aspera, Cupania americana. Se encontró algunas especies sensibles a la deficiencia de nitrógeno y otras a la deficiencia de azufre. El grupo de T. chrysanta, M. nobilis y H. patens mostró alta sensibilidad a la deficiencia de nitrógeno, mientras que C. americana y A. aspera presentaron sensibilidad a la deficiencia de azufre, representada en menor crecimiento promedio para todas las variables evaluadas: altura, diámetro en el cuello de la raíz, materia seca radical y materia seca aérea. Las representaciones HJ-Biplot, utilizadas para caracterizar la respuesta por especie a cada tratamiento en todas las unidades experimentales, evidenciaron los bajos rendimientos en crecimiento para las deficiencias en nitrógeno y azufre. El desbalance de bases calcio/magnesio y magnesio/potasio afectó el crecimiento en altura de todas las especies, evidenciado en los altos crecimientos obtenidos para los tratamientos deficientes en calcio y magnesio. Debido a esto, las fórmulas nutricionales utilizadas en vivero deben reajustarse a las exigencias individuales de las especies, para producir mejores árboles para la ciudad.

  17. Violencia urbana y estrategias de protección de mujeres en Cali (Colombia

    Directory of Open Access Journals (Sweden)

    Sánchez Zapata, Alejandra

    2016-02-01

    Full Text Available Resumen. Esta investigación reconstruye las estrategias de protección en contextos urbanos desde fragmentos de la historia de vida de dos mujeres víctimas de la violencia social y política, para ello se usó la metodologia feminista en psicologia comunitaria, la cual reconoce en el discurso femenino, la experiencia de vida como fuente de saberes legitimos. (Campbell & Wasco, 2000. Los resultados evidencian que las mujeres utilizan estrategias de protección basadas en los saberes construidos en su experiencia de vida, su sitio de origen y las relaciones de poder. Pone de manifiesto la relevancia de investigar sobre la violencia urbana. Abstract. This piece of research reconstructs the protection strategies in urban contexts from fragments of life histories from two women, victims of the social and political violence. For such a purpose, a feminist methodology in community psychology was used, which recognizes, in the feminist discourse, the life experience as a source of legitimate knowledge (Campbell & Wasco, 2000. The results make evident that women use protection strategies based on the knowledge built in their life experience, their place of origin, and the power relationships. It reveals the relevance of researching on urban violence.

  18. Situações periféricas: etnografia comparada de pobrezas urbanas

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    Ronaldo de Almeida

    2008-11-01

    Full Text Available Este artigo discute a articulação entre pobreza urbana e desigualdade social com base em estudos etnográficos realizados na cidade de São Paulo. Partimos da constatação de que estão em curso melhorias materiais entre a população considerada pobre, mas isso não afeta a reprodução das distâncias sociais. Por meio da comparação de três pesquisas etnográficas, propomos sistematizar e discutir alguns mecanismos sociais comuns que geram essa oscilação entre atenuação da pobreza e reprodução da desigualdade.This article discusses the connection between urban poverty and social inequality, based on ethnographical studies in the city of São Paulo. We start from the statement that there are actual improvements in the material conditions among the population considered poor, but the reproduction of social distances stay untouched. Based on a comparison of three different cases, we try to discuss a few social mechanisms that are in the origins of this variation between relief of poverty and reproduction of inequalities.

  19. Calidad de vida relativa a salud en la población urbana de Cuba

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    Rodolfo Jova Morel

    2013-06-01

    Full Text Available Se realizó un estudio descriptivo y transversal durante el 2010, de 5 936 personas de 15 años y más como muestra representativa del país, con muestreo por conglomerado en varias etapas, con vistas a determinar la calidad de vida relativa a salud en la población urbana de Cuba. Las variables sociodemográficas utilizadas resultaron ser: edad, sexo y color de la piel; las del cuestionario genérico EuroQol: movilidad, cuidado personal, actividades cotidianas, dolor/malestar y ansiedad/depresión. La mayoría de las personas presentaron movilidad, cuidado personal y actividades cotidianas conservadas. Se concluye que los mestizos del sexo masculino menores de 45 años, mostraron mayor calidad de vida relativa a salud y que dicho cuestionario puede ser válido para describir este indicador en la citada población.

  20. Indicadores Estructurales y Conglomerados de Actores en la Red Social de una Subcultura Urbana

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    José Hernando Ávila-Toscano

    2011-01-01

    Full Text Available Este estudio buscó identificar la estructura de socialización de una subcultura urbana con la medición de indicadores estructurales de su red social e identificación de subagrupaciones. Se empleó el instrumento Arizona Social Support Interview Schedule (ISSIS con 11 miembros de la subcultura roqueros. Se procesaron los datos mediante el análisis de redes sociales (ARS con el software Ucinet, para detectar conjuntos de actores con el procedimiento de conglomerados jerárquicos; y los gráficos de la red se crearon con NetDraw. Se identificaron niveles moderados de indicadores estructurales y las agrupaciones presentaron un número amplio de actores según el criterio de atracción por similaridad. Los subgrupos en la red fueron escasos, lo que muestra a la subcultura como una unidad social cuya integración se da por vinculaciones estrechas entre sus miembros.

  1. Emergencia de las relaciones intergeneracionales en una escuela pública urbana

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    Ligia López-Moreno

    2011-01-01

    Full Text Available El análisis genealógico, des-ocultó cómo en la actualidad se configuran relaciones intergeneracionales entre jóvenes alumnos, alumnas y maestros, maestras adultos y adultas del nivel básico secundario de una escuela pública urbana, examinando la interacción cotidiana en el campo de las relaciones de poder múltiples y móviles en un doble proyecto: la historia de prácticas escolares desde donde se ha creado la separación maestro-alumno y, la historia de las estructuras de poder que han sido practicadas y modificadas en esta escuela.Interrogamos por niveles de existencia del poder, por formas concretas de ejercicio de poder y la constitución de modos de subjetivación (ser maestro, maestra, ser alumno, alumna y los efectos consecuentes en la configuración de las relaciones intergeneracionales (ser adulto, adulta, ser joven hombre mujer en la escuela.

  2. El urbanismo contra lo urbano. La ciudad y la vida urbana en Henri Lefebvre

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    Manuel Delgado Ruiz

    2018-01-01

    Full Text Available Henri Lefebvre coloca en el eje de su teoría sobre la vida urbana la oposición entre el espacio vivido por quienes lo usan o sueñan y el espacio abstracto que creen organizar los tecnócratas de la ciudad, que raramente reconocen hasta qué punto su “creatividad” está sometida a intereses privados o institucionales. Tras ese espacio hipotético sobre el que urbanistas y arquitectos trabajan no hay otra cosa que mera ideología, es decir, fantasma que recubre y disfraza las relaciones sociales reales de producción. Frente -o de espaldas- a ese orden espacial meramente teórico de los “especialistas”, lo que las ciudades conocen es la actividad constante o inminente de lo urbano, entendido como apoteosis y exacerbación de lo social, dinamismo siempre activado de acontecimientos y quehaceres sobre el que los “expertos” aplican planes y proyectos, pero del que no saben en realidad nada, acaso por lo cual pugnan por anularlo.

  3. Ricostruzione di una scena urbana 3D utilizzando VisualSfM.

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    Laura Inzerillo

    2013-10-01

    Full Text Available Le tecniche di computer vision oggi danno la possibilità di costruire in maniera rapida e automatica modelli 3D dettagliati a partire da dataset fotografici. La comunità accademica ha visto una crescente attenzione alla ricostruzione 3D a scala urbana. Tra i vari strumenti oggi a disposizione spicca VisualSfM sviluppato dall’università di Washingthon e Google. Si tratta di una Interfaccia grafica open source strutturata in algoritmi dedicati alla tecnica di Structure from Motion (SfM. VisualSfM utilizza un estrattore di features chiamato SIFTGPU e un algoritmo di Bundle Adjustment Multicore. Inoltre è possibile ottenere una nuvola di punti densa utilizzando gli algoritmi CMVS/PMVS2. La finalità di questo studio è di verificare l’accuratezza metrica delle ricostruzioni attraverso l’utilizzo integrato di VisualSfM e CMVS/PMVS2. L’approccio quindi è stato testato su diversi dataset di una certa entità strutturati da collezioni fotografiche ragionate. 

  4. Transformaciones urbanas y de la estructura social de un barrio de la ciudad de Buenos Aires

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    Luis Baer

    2010-01-01

    Full Text Available Algunos estudios abordan los procesos urbanos que replantean la estructura, los usos del suelo y el paisaje de la ciudad; otros analizan los efectos de estos cambios en las condiciones de vida, las prácticas colectivas y las representaciones sociales. Este trabajo intenta ubicarse entre ambas perspectivas. Recorremos las intervenciones urbanas que reestructuraron un barrio de la ciudad de Buenos Aires entre 1998 y 2004, el barrio del Abasto. Esta transformación la impulsó el sector privado y consistió en el acondicionamiento de grandes emplazamientos urbanos para usos comerciales, residenciales y de entretenimiento. Investigamos los cambios urbanos desde las prácticas y representaciones cotidianas de los residentes de las Torres de Abasto, un grupo de personas que se mudó al barrio cuando ya había comenzado su reconversión. Analizamos los vínculos y las representaciones que se establecen en dicho complejo residencial y en el barrio que lo rodea.

  5. A VISUALIDADE URBANA CONTEMPORÂNEA COMO CAMPO DE ESTUDOS INTERDISCIPLINARES

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    Francisco Antônio Zorzo

    2017-02-01

    Full Text Available O artigo traz uma discussão sobre o estudo da visualidade urbana segundo uma abordagem interdisciplinar. Segundo a proposta aqui indicada, parece útil entender os fenômenos urbanos sob um outro olhar. Torna-se muito conveniente considerar a interação entre tecnologia, arte e ciência na constituição dos estudos sobre o ambiente urbano e sobre a produção da imagen. Tendo em mente tal concepção, pode-se partir de uma referência mais concreta para estudar a cidade e a visualidade, como um campo de múltiplas produções em abordagem interdisciplinar. Para isso foi selecionada a produção do grafite nas metrópoles brasileiras. Nos muros de Salvador há uma série de grafites que merecem a reflexão e um acolhimento crítico por tratarem exatamente de problematizar o olho e o olhar no ambiente da cidade.

  6. Planificación urbana y contaminación atmosférica

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    García Arroyo, Arturo

    1972-12-01

    Full Text Available By taking Into account turbulence and differences in pressure created around a building subjected to wind action. It Is possible to discover the design guidelines which best permit Increased ventilation In an urban zone. Increase in wind velocity and changes of direction can be used to diminish air pollution at definite points in large urban areas. For a practical study of the problem It Is recommended to use small models in a low velocity wind tunnel.Teniendo en cuenta las turbulencias y diferencias de presión que se forman alrededor de un edificio sometido a la acción del viento, es posible encontrar las normas óptimas de diseño que permiten un aumento en la ventilación de la zona en que aquél se levante. El incremento de la velocidad del aire y los cambios de dirección, pueden emplearse para disminuir la contaminación atmosférica en determinados puntos de las grandes áreas urbanas. Para un estudio práctico del problema se recomienda el empleo del método de modelos reducidos en un túnel de viento de baja velocidad.

  7. A mobilidade urbana: uma agenda inconclusa ou o retorno daquilo que não foi

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    Alexandre de Ávila Gomide

    2013-01-01

    Full Text Available O texto apresenta um resgate histórico das políticas de mobilidade urbana no Brasil, demonstrando como o tema foi tratado conforme o contexto político nas últimas décadas. O foco recai no período de redemocratização até os dias atuais, apresentando os avanços e desafios do setor, ilustrados nas demandas da sociedade e nas respostas governamentais. São estabelecidos os vínculos das pressões populares com a criação de marcos institucionais, estruturas administrativas e instrumentos financeiros em prol da melhoria da oferta dos serviços de transporte público coletivo, bem como os sucessos, fracassos e incompletudes das soluções criadas para suprir os anseios sociais. Com base nessa análise são sugeridas algumas direções, entendidas como contribuições ao recente retorno do tema à agenda decisória dos governos.

  8. Prevalencias de malnutrición y parasitosis en áreas urbanas, periurbanas y rurales

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    Cesani Rossi, María Florencia

    2007-01-01

    Full Text Available Se analizaron el estado nutricional y las parasitosis intestinales de niños de 3 a 6 años de edad residentes en zonas urbanas (U, periurbanas (PU y rurales (R del partido de Brandsen. Bajo peso para la edad (BP/E, baja talla para la edad (BT/E y bajo peso para la talla (BP /T fueron estimados usando la referencia de CDC/NCHS. El sobrepeso (S y la obesidad (O fueron calculados siguiendo los criterios de la IOTF. El análisis parasitológico se realizó mediante muestras de materia fecal seriadas y escobillado anal. Las prevalencias de malnutrición y parasitosis fueron asociadas con características socioambientales de cada zona. PU presentó porcentajes de BT/E y parasitosis significativamente mayores que U (p<0,01. Se registraron 8 especies parásitas en PU, 7 en U y 4 en R, siendo E. vermicularis, B. hominis y G. lamblia las más frecuentes. PU tuvo el mayor porcentaje de poliparasitismo. Aunque el exceso de peso fue elevado en las tres zonas, fue significativamente mayor en R respecto a U (p<0,01. La zona periurbana presenta deficientes condiciones socio-ambientales para el crecimiento y salud de los niños preescolares.

  9. Rura-ciudades como alternativa de planeación urbana inteligente

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    Silverio Hernández Moreno

    2016-12-01

    Full Text Available Este trabajo contiene un acercamiento basado en un cambio de paradigma relacionado con la planeación de ciudades, en donde por medio de una revisión de literatura y reflexión de varios temas, tales como derecho a la ciudad, sustentabilidad urbana, mitigación del cambio climático, metabolismo urbano e impacto ambiental en el hábitat urbano y natural, se llega a un nuevo tipo de planeación de ciudades de bajo carbono, denominadas rura-ciudades. Dentro de sus características particulares, resalta el empleo de los usos de suelo de tipo rural complementados con usos de suelo de tipo urbano, conformando un híbrido que mejora el metabolismo urbano de las ciudades, proporcionando mayor calidad de vida a sus habitantes, disminución en el deterioro y fragmentación del medio rural y de los distintos impactos ambientales causados por la urbanización.

  10. El sector empresarial y la contaminación urbana en Colombia

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    Carlos Manuel Herrera Santos

    2009-11-01

    Full Text Available La baja calidad del ambiente en muchas ciudades en Colombia impulsa la más ambiciosa actualización de la historia colombiana en materia de contaminación en temas de residuos, emisiones atmosféricas y vertimientos. Las iniciativas involucran tanto los procesos como los productos. El sector productivo está respondiendo a través de estrategias combinadas de prevención y control, además de extender la gestión ambiental a través de su cadena de valor. No obstante, garantizar una calidad ambiental urbana requiere un enfoque más amplio que incorpore temas como la salud pública, la planificación, la gestión sectorial, la protección de los ecosistemas y la competitividad./The low quality of the environment in many Colombian cities, drives the most ambitious renovation of Colombian history in terms of pollution in areas of waste, air emissions and discharges. The initiatives involve both processes and products. The productive sector is responding through combined strategies for prevention and control, as well as extending environmental management across its value chain. However, ensuring a quality urban environment requires a broader approach that incorporates issues such as public health, planning, sectoral management, ecosystem protection and competitiveness.

  11. Localizando o espaço público: Gentrification e cultura urbana

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    Rogério Proença Leite

    2012-12-01

    Full Text Available O artigo discute a noção de espaço público, tomando como referente um estudo de caso sobre as políticas de requalificação urbana e gentrification no Recife, Brasil. A partir do estudo de caso, o autor problematiza o modo como nos usos do espaço (urbano se confrontam concepções e práticas diversas de relação com o espaço público, atendendo em particular às tensões que emergem nas ressignificações que os processos de requalificação arrastam consigo. A análise do caso, centrada nos modos diversos e conflituantes como, nesse quadro, o espaço público se constitui como espaço de comunicação e cidadania, sustenta uma discussão teórica em torno da noção de espaço público, problematizada no seu duplo sentido: de esfera pública da comunicação e participação e de espaço físico de acesso e uso público.

  12. HOSPITALIDADE URBANA DO CENTRO HISTÓRICO DE PELOTAS/RS

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    Camila Osório Dutra

    2017-11-01

    Full Text Available O presente trabalho tem como objeto de estudo a Hospitalidade Urbana do Centro Histórico da cidade de Pelotas/RS. Tendo como objetivo compreender se o Centro Histórico desta cidade, é, ou não, hospitaleiro, através das categorias de análise: Acessibilidade, Identidade e Legibilidade. Para isto, foram realizadas pesquisas bibliográficas e questionários com moradores e turistas em diferentes pontos da cidade. Relatou-se que a hospitalidade de legibilidade se refere, cada indivíduo cada usuário de um espaço tem uma visão, uma percepção, do que é mais interessante, do que é guardado em suas experiências e consequentemente em suas memórias visuais. Além disso, em futuros estudos, outros pontos que podem ser abordados são as condições de acesso em diferentes municípios e as identidades de diferentes cidades.

  13. Crisis, descentralización y gobernabilidad urbana en el área metropolitana de Caracas

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    María Pilar GARCÍA-GUADILLA

    2009-11-01

    Full Text Available RESUMEN: El proceso de reforma política y descentralización venezolano fueron interpretados como elementos necesarios para profundizar la democracia en este país. Sin embargo, la crisis econónica y lo incompleto del proceso de descentralización han significado a la larga un descenso en el nivel de gobernabilidad general. En este contexto, la autora analiza el caso del área metropolitana de Caracas y explica las peculiaridades de la gobernabilidad urbana en situaciones de aguda crisis económica.ABSTRACT: The Venezuelan process of political reform and transference of competentes to the regional and local levels were considered as constituent elements to deep democracy in this country. However, the economic crisis and the unfinished devolution have meant at the long run a decline in the level of general governability. In this context, the author analyzes the metroplitan area of Caracas, trying to explain the urban governability in contexts of grave economic crisis.

  14. Turismo y contaminación ambiental en la periferia urbana de Acapulco: Ciudad Renacimiento

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    Rocío López Velasco

    2012-01-01

    Full Text Available Nuestro estudio aborda los problemas de sostenibilidad del desarrollo turístico de una ciudad como la de Acapulco, donde se experimenta un desarrollo desigual y excluyente; enfocándonos en los espacios periurbanos donde el deterioro ambiental y la contaminación son consustanciales a la escasez de servicios y a la presencia de pobreza. Ciudad Renacimiento, forma parte del área periurbana de la ciudad y personifica un sector poblacional donde se detectan diferentes fuentes de contaminación. Metodología: se aplicó la técnica: Evaluación Rápida de Fuentes de Contaminación Ambiental (ERFCA para detectar fuentes de contaminación en una zona urbana donde la actividad industrial es incipiente, pero las actividades comerciales y de servicios abundan. Conclusiones: Se constató que el turismo no planeado se convierte en un obstáculo para un desarrollo sustentable; Acapulco es un ejemplo de ello, pues en él se reproducen las asimetrías socioeconómicas que impiden un desarrollo integral. De igual manera, como en otras latitudes, en Acapulco el turismo enfrenta dos alternativas: la sustentabilidad o la modernidad globalizadora, un reto de difícil integración en nuestro país, debido a lapobreza existente y a las dificultades para impulsar un crecimiento equilibrado, el cual es hoy por hoy una prioridad indiscutible.

  15. Renovación urbana. ¿Una respuesta al pánico moral?

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    Carlos Josu00E9 Suu00E1rez G.

    2010-01-01

    Full Text Available En este artículo se analizan los procesos de transformación y renovación urbana en el centro histórico de Bogotá, vinculados con la relocalización de poblaciones vulnerables que habitan esta zona, considerada como violenta y de alta pelivgrosidad. Estas acciones de la administración distrital se están ejecutando a partir de las premisas del urbanismo moderno que dictan reglas higiénicas para combatir los tugurios. La coyuntura actual de los barrios San Bernardo y Voto Nacional, que presentan un alto deterioro arquitectónico y que van a ser sometidos a un proceso de renovación enmarcado en el megaproyecto Ciudad Salud, nos ofrece un escenario privilegiado y una oportunidad única para el análisis de este fenómeno. Estos procesos que buscan modernizar la ciudad y combatir la criminalidad y la delincuencia deben ser estudiados críticamente. Así, desde una perspectiva antropológica, se busca esclarecer los significados sociales de estos procesos de renovación.

  16. RESILIENCIA PARA REDUCIR LA VULNERABILIDAD A LOS RIESGOS DE LA VIVIENDA POBRE URBANA. RESISTENCIA, ARGENTINA, 2007

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    Gabriela Soledad Gauto de Paz

    2010-01-01

    Full Text Available Este trabajo forma parte de los avances que se han logrado en una investigación que fue iniciada en el año 20051 (que a la fecha continúa2 en un barrio pobre de una ciudad ubicada al norte de la Argentina, cuyo trabajo de campo se extendió durante el año 2007. En esta instancia se pretende mostrar cómo la incorporación de variables sociales como el concepto de vulnerabilidad y, más específicamente uno de sus componentes, la resiliencia, permite aproximarse a las estrategias y recursos que implementan las familias pobres urbanas para enfrentar y superar los riesgos que puede entrañar la vivienda para su salud. Se relata el trabajo realizado con 4 (cuatro casos. La metodología utilizada en la investigación es cualitativa y se empleó el método Estudio de Caso Biográfico. Entre los principales hallazgos, se puede mencionar que la amenaza en la vivienda es relativa a la vulnerabilidad de sus habitantes, que los recursos activos son dinámicos y que cada caso hizo su propio proceso de resiliencia, lo que se constituyó en experiencia para afrontar situaciones posteriores.

  17. Alcances e impactos del Programa Hábitat en comunidades pobres urbanas de México

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    Gerardo ORDÓÑEZ-BARBA

    2013-01-01

    Full Text Available Este trabajo resume los resultados de una evaluación del Programa Hábitat que tuvo como pro - pósito valorar los alcances e impactos de su intervención. Después de revisar las modificaciones a su diseño, dimensionar sus niveles de cobertura y analizar los impactos generados en las condi - ciones de vida de sus beneficiarios mediante una metodología de tipo experimental, se concluye que: a los cambios introducidos en las reglas de operación han limitado su capacidad de actua - ción, convirtiéndolo en un programa especializado en la introducción de servicios básicos e in - fraestructura urbana; b enfrenta grandes limitaciones para desplegar una cobertura acorde con el tamaño de su universo potencial y c tiene efectos significativos sobre un conjunto de indicadores que denotan mejoras en la calidad de vida y la satisfacción de sus beneficiarios, particularmente en lo que se refiere a las condiciones físicas del entorno urbano, aunque no se observan cambios en las condiciones sociales al interior de las comunidades.

  18. Killing malignant melanoma cells with protoporphyrin IX-loaded polymersome-mediated photodynamic therapy and cold atmospheric plasma

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    Wang M

    2017-05-01

    Full Text Available Mian Wang,1 Benjamin M Geilich,2 Michael Keidar,3 Thomas J Webster1,4 1Department of Chemical Engineering, 2Department of Bioengineering, Northeastern University, Boston, MA, 3Department of Mechanical and Aerospace Engineering, George Washington University, Washington, DC, USA; 4Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, People’s Republic of China Abstract: Traditional cancer treatments contain several limitations such as incomplete ablation and multidrug resistance. It is known that photodynamic therapy (PDT is an effective treatment for several tumor types especially melanoma cells. During the PDT process, protoporphyrin IX (PpIX, an effective photosensitizer, can selectively kill cancer cells by activating a special light source. When tumor cells encapsulate a photosensitizer, they can be easily excited into an excited state by a light source. In this study, cold atmospheric plasma (CAP was used as a novel light source. Results of some studies have showed that cancer cells can be effectively killed by using either a light source or an individual treatment due to the generation of reactive oxygen species and electrons from a wide range of wavelengths, which suggest that CAP can act as a potential light source for anticancer applications compared with UV light sources. Results of the present in vitro study indicated for the first time that PpIX can be successfully loaded into polymersomes. Most importantly, cell viability studies revealed that PpIX-loaded polymersomes had a low toxicity to healthy fibroblasts (20% were killed at a concentration of 400 µg/mL, but they showed a great potential to selectively kill melanoma cells (almost 50% were killed. With the application of CAP posttreatment, melanoma cell viability significantly decreased (80% were killed compared to not using a light source (45% were killed or using a UV light source (65% were killed. In summary, these results indicated for the

  19. REESTRUTURAÇÃO URBANA E CRIAÇÃO DE NOVAS CENTRALIDADES: considerações sobre os Shopping Centers

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    Lidiane Aparecida Alves

    2011-04-01

    Full Text Available O espaço urbano, entendido enquanto a condição, meio e produto das ações realizadas pela sociedade ao longo do tempo, apresenta-se em constante reestruturação, segundo as imposições do modo capitalista de produção, que passa por modificações, a fim de assegurar a reprodução do capital. Como resultado do processo de reestruturação produtiva tem-se reestruturação urbana, consubstanciada nas novas centralidades, a exemplo dos Shopping Centers. Essas novas centralidades criam novas dinâmicas econômicas e espaciais (redefinindo as funções em seu entorno e da área central. Diante da relevância dessa temática, através deste estudo busca tecer considerações sobre os Shopping Centers, vistos enquanto resultado das modificações no processo produtivo, cujos reflexos são diretamente sentidos na dinâmica urbana, no âmbito do processo de reestruturação urbana, a partir da criação de novas centralidades. Espera-se a partir das discussões realizadas, contribuir com os estudos de geografia urbana, especificamente com aqueles referentes ao processo de reestruturação urbana, e surgimento de novas centralidades.

  20. Seguridad urbana y vulnerabilidad social en Ciudad Juárez. Un modelo desde la perspectiva de análisis espacial

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    Sara Morales Cárdenas

    2013-01-01

    Full Text Available Partiendo del concepto de “seguridad urbana”, introducido por un-Habitat en 2007 dentro de la agenda de Ciudades seguras, el presente trabajo propone analizar a Ciudad Juárez, urbe considerada entre las más inseguras y violentas del país y del mundo. Se presenta el desarrollo de un índice de seguridad urbana (isu basado en un modelo multicriterio de análisis espacial que propone identificar y explicar cómo se manifiestan territorialmente las amenazas a la seguridad urbana y su relación con los índices de vulnerabilidad social asociada a la pobreza. La importancia de este análisis radica en la necesidad de articular los estudios estadísticos y los patrones de distribución de las amenazas a la seguridad urbana con los procesos de planificación urbana como instrumento preventivo que permita formular políticas para reducir la inseguridad urbana.

  1. A CONTRIBUIÇÃO DA ACADEMIA PARA MOBILIDADE URBANA SUSTENTÁVEL POR MEIO DO PROGRAMA DE EXTENSÃO UNIVERSITÁRIA DA UFPR – CICLOVIDA

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    Silvana Nakamori

    2016-06-01

    Full Text Available Congestionamentos, acidentes de trânsito e poluição são alguns problemas resultantes de uma cultura de mobilidade que prioriza o transporte individual por meio do automóvel e o resultado dessa prioridade é a deteriorização da qualidade de vida urbana. A fim de tentar reverter esse panorama surge na UFPR o Programa de Extensão Universitária Ciclovida, acreditando que a Academia tem a obrigação de estar na vanguarda das transformações que a sociedade necessita, pois através da pesquisa, ensino e extensão visa-se à formação de uma cultura de mobilidade urbana saudável e sustentável, pelo do uso da bicicleta como um dos meios de transporte. O objetivo deste artigo é demonstrar as contribuições da academia para a mobilidade urbana sustentável focando no Programa Ciclovida e a metodologia utilizada foi à pesquisa documental, sendo também uma pesquisa aplicada, qualitativa, exploratória, descritiva e bibliográfica. Dentre os resultados está à descrição do Programa e o Desafio Intermodal (anos de 2007 a 2013, demonstrando que a Academia pode sim contribuir com a mobilidade urbana. Palavras chaves: Mobilidade Urbana Sustentável. Extensão Universitária. Bicicleta.

  2. Renovación urbana y gentrificación post-catástrofe en Concepción: el caso Aurora de Chile

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    Christian Paulo Matus Madrid

    2016-06-01

    Full Text Available El estudio de caso de la Población Aurora de Chile evidencia la existencia de una estrategia de renovación urbana que promueve la gentrificación y que utiliza el desastre como una herramienta simbólica para justificar el desarrollo de operaciones urbanas que generan desplazamientos. A través de una metodología de revisión de instrumentos de planificación urbana, entrevistas a informantes clave y grupos de conversación con pobladores, se indagan las diferentes etapas del proceso de renovación urbana, que dan cuenta de los discursos y construcciones simbólicas sobre la ciudad y su desarrollo post catástrofe. Finalmente, se plantea la existencia de una estrategia de renovación urbana no explicitada en un proyecto de planificación, que utiliza el Terremoto como oportunidad para gatillar la aceleración de proyectos público-privados, que son impuestos a la comunidad, naturalizando la necesidad de que Aurora "sacrifique" su territorio por el bien común y desarrollo de la ciudad.

  3. Integração de condicionantes de morfologia urbana no desenvolvimento de metodologia para planejamento energético urbano

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    Karin Regina de Casas Castro Marins

    Full Text Available O objetivo desse artigo é apresentar as características gerais de uma nova metodologia para planejamento energético urbano, detalhando os procedimentos para integração de condicionantes de morfologia urbana, que constitui a primeira etapa de aplicação metodológica. Esta abordagem é inovadora e focada na integração de estratégias e soluções em morfologia e mobilidade urbanas, edifícios, energia e meio ambiente para planejamento de áreas em desenvolvimento urbano, novas ou a serem requalificadas, na escala de distritos, bairros e unidades de vizinhança. A análise dos resultados da aplicação metodológica no caso da operação urbana Água Branca indicou que a ocupação urbana por edificações e as densidades construída e populacional necessitavam ser compatibilizadas com a área livre requerida ao adequado dimensionamento da seção viária, no que tange a aspectos de climatologia e de provimento de infraestrutura e demanda para mobilidade urbana. Esta era uma premissa para o aproveitamento da luz e da energia solar em edificações e para que o sistema de transporte urbano fosse mais funcional e energeticamente mais eficiente.

  4. Two-peaked 5-ALA-induced PpIX fluorescence emission spectrum distinguishes glioblastomas from low grade gliomas and infiltrative component of glioblastomas.

    Science.gov (United States)

    Montcel, Bruno; Mahieu-Williame, Laurent; Armoiry, Xavier; Meyronet, David; Guyotat, Jacques

    2013-04-01

    5-ALA-induced protoporphyrin IX (PpIX) fluorescence enables to guiding in intra-operative surgical glioma resection. However at present, it has yet to be shown that this method is able to identify infiltrative component of glioma. In extracted tumor tissues we measured a two-peaked emission in low grade gliomas and in the infiltrative component of glioblastomas due to multiple photochemical states of PpIX. The second emission peak appearing at 620 nm (shifted by 14 nm from the main peak at 634 nm) limits the sensibility of current methods to measured PpIX concentration. We propose new measured parameters, by taking into consideration the two-peaked emission, to overcome these limitations in sensitivity. These parameters clearly distinguish the solid component of glioblastomas from low grade gliomas and infiltrative component of glioblastomas.

  5. Bianchi IX dynamics in bouncing cosmologies: homoclinic chaos and the BKL conjecture

    Science.gov (United States)

    Maier, Rodrigo; Damião Soares, Ivano; Valentino Tonini, Eduardo

    2015-12-01

    We examine the dynamics of a Bianchi IX model with three scale factors on a 4-dim Lorentzian brane embedded in a 5-dim conformally flat empty bulk with a timelike extra dimension. The matter content is a pressureless perfect fluid restricted to the brane, with the embedding consistently satisfying the Gauss-Codazzi equations. The 4-dim Einstein equations on the brane reduce to a 6-dim Hamiltonian dynamical system with additional terms (due to the bulk-brane interaction) that avoid the singularity and implement nonsingular bounces in the model. We examine the complex Bianchi IX dynamics in its approach to the neighborhood of the bounce which replaces the cosmological singularity of general relativity. The phase space of the model presents (i) two critical points (a saddle-center-center and a center-center-center) in a finite region of phase space, (ii) two asymptotic de Sitter critical points at infinity, one acting as an attractor to late-time acceleration and (iii) a 2-dim invariant plane, which together organize the dynamics of the phase space. The saddle-center-center engenders in the phase space the topology of stable and unstable 4-dim cylinders R × S 3, where R is a saddle direction and S 3 is the center manifold of unstable periodic orbits, the latter being the nonlinear extension of the center-center sector. By a proper canonical transformation the degrees of freedom of the dynamics are separated into one degree connected with the expansion/contraction of the scales of the model, and two rotational degrees of freedom associated with the center manifold S 3. The typical dynamical flow is thus an oscillatory mode about the orbits of the invariant plane. The stable and unstable cylinders are spanned by oscillatory orbits about the separatrix towards the bounce, leading to the homoclinic transversal intersection of the cylinders, as shown numerically in two distinct simulations. The homoclinic intersection manifold has the topology of R × S 2 consisting of

  6. Hořava-Lifshitz bouncing Bianchi IX universes: A dynamical system analysis

    Science.gov (United States)

    Maier, Rodrigo; Soares, Ivano Damião

    2017-11-01

    We examine the Hamiltonian dynamics of bouncing Bianchi IX cosmologies with three scale factors in Hořava-Lifshitz (HL) gravity. We assume a positive cosmological constant plus noninteracting dust and radiation as the matter content of the models. In this framework the modified field equations contain additional terms which turn the dynamics nonsingular. The six-dimensional phase space presents (i) two critical points in a finite region of the phase space, (ii) one asymptotic de Sitter attractor at infinity and (iii) a two-dimensional invariant plane containing the critical points; together they organize the dynamics of the phase space. We identify four distinct parameter domains A , B , C and D for which the pair of critical points engenders distinct features in the dynamics, connected to the presence of centers of multiplicity 2 and saddles of multiplicity 2. In the domain A the dynamics consists basically of periodic bouncing orbits, or oscillatory orbits with a finite number of bounces before escaping to the de Sitter attractor. The center with multiplicity 2 engenders in its neighborhood the topology of stable and unstable cylinders R ×S3 of orbits, where R is a saddle direction and S3 is the center manifold of unstable periodic orbits. We show that the stable and unstable cylinders coalesce, realizing a smooth homoclinic connection to the center manifold, a rare event of regular/nonchaotic dynamics in bouncing Bianchi IX cosmologies. The presence of a saddle of multiplicity 2 in the domain B engenders a high instability in the dynamics so that the cylinders emerging from the center manifold about P2 towards the bounce have four distinct attractors: the center manifold itself, the de Sitter attractor at infinity and two further momentum-dominated attractors with infinite anisotropy. In the domain C we examine the features of invariant manifolds of orbits about a saddle of multiplicity 2 P2. The presence of the saddle of multiplicity 2 engenders bifurcations

  7. The Effect of Using Origami Paper to Teach the Perimeter of Plane Figures on Cognitive Achievement of Students Grade IX

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    Yael Narwastu Jati

    2017-03-01

    BAHASA INDONESIA ABSTRAK: Desain penelitian eksperimen ini dilakukan untuk melihat apakah terdapat pengaruh penggunaan kertas origami untuk mengajar keliling dari suatu bidang datar terhadap hasil belajar kognitif siswa kelas IX dan bagaimana penggunaan tersebut mempengaruhi hsil belajar. Sampel penelitian adalah 16 siswa kelas IX-A sebagai kelompok ekperimen yang akan menggunakan kertas origami. Data diperolehh dari hasil pre-tests dan post-tests. Hasil penelitian menunjukkan ada perbedaan rata-rata skor yang signifikan antara hasil pre-tests dan post-tests yang di duga, yaitu 4.0 (normalized gain, bahkan mencapai 0.8 yang termasuk golongan tinggi. Sehingga, dapat disimpulkan bahwa terdapat pengaruh pada hasil belajar kognitif pada pengajaran keliling suatu bidang datar dengan menggunakan kertas origami

  8. The Role of Hexon Protein as a Molecular Mold in Patterning the Protein IX Organization in Human Adenoviruses.

    Science.gov (United States)

    Reddy, Vijay S

    2017-09-01

    Adenoviruses are respiratory, ocular and enteric pathogens that form complex capsids, which are assembled from seven different structural proteins and composed of several core proteins that closely interact with the packaged dsDNA genome. The recent near-atomic resolution structures revealed that the interlacing continuous hexagonal network formed by the protein IX molecules is conserved among different human adenoviruses (HAdVs), but not in non-HAdVs. In this report, we propose a distinct role for the hexon protein as a "molecular mold" in enabling the formation of such hexagonal protein IX network that has been shown to preserve the stability and infectivity of HAdVs. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. PEMBERDAYAAN EKONOMI MASYARAKAT RT 05 RW IX KELURAHAN KROBOKAN KECAMATAN SEMARANG BARAT MELALUI PENGOLAHAN BAHAN PANGAN LOKAL DAN PEMASARANNYA

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    Mei Sulistyoningsih

    2015-09-01

    Full Text Available Abstract ?é?á The purpose of this activity is to increase of people?óÔé¼Ôäós income through local food processing and its marketing by empowerment of communities. Participants of these activities include member of RT 05 RW IX, Kelurahan Krobokan, sub-district of West Semarang, Semarang City. The method are discussion, practice, and simulation. Implementation of activities is to encourage community to be entrepreneurs in increasing family incomes not only just relying on the income from the work as laborers or workers. Training activities of local food into a healthy diet has a positive response from family group in RT 05 RW IX, Kelurahan Krobokan, sub-district of West Semarang, Semarang City. ?é?á Keywords : family income, local food, entrepreneur, marketing

  10. MO-FG-BRA-07: Theranostic Gadolinium-Based AGuIX Nanoparticles for MRI-Guided Radiation Therapy

    International Nuclear Information System (INIS)

    Detappe, A; Rottmann, J; Kunjachan, S; Berbeco, R; Tillement, O

    2015-01-01

    Purpose: AGuIX are gadolinium-based nanoparticles, initially developed for MRI, that have a potential role in radiation therapy as a radiosensitizer. Our goal is to demonstrate that these nanoparticles can both be used as an MRI contrast agent, as well as to obtain local dose enhancement in a pancreatic tumor when delivered in combination with an external beam irradiation. Methods: We performed in vitro cell uptake and radiosensitization studies of a pancreatic cancer cell line in a low energy (220kVp) beam, a standard clinical 6MV beam (STD) and a flattening filter free clinical 6MV beam (FFF). After injection of 40mM of nanoparticles, a biodistribution study was performed in vivo on mice with subcutaneous xenograft pancreatic tumors. In vivo radiation therapy studies were performed at the time point of maximum tumor uptake. Results: The concentration of AGuIX nanoparticles in Panc-1 pancreatic cancer cells, determined in vitro by MRI and ICPMS, peaks after 30 minutes with 0.3% of the initial concentration (5mg/g). Clonogenic assays show a significant effect (p<0.05) when the AGuIX are coupled with MV photon irradiation (DEF20%=1.31). Similar AGuIX tumor uptake is found in vivo by both MRI and ICPMS 30 minutes after intravenous injection. For long term survival studies, the choice of the radiation dose is determined with 5 control groups (3mice/group) irradiated with 0, 5, 10, 15, and 20Gy. Afterwards, 4 groups (8mice/group) are used to evaluate the effect of the nanoparticles. A Logrank test is performed as a statistical test to evaluate the effect of the nanoparticles. Conclusion: The combination of the MRI contrast and radiosensitization properties of gadolinium nanoparticles reveals a strong potential for usage with MRI-guided radiation therapy

  11. Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets.

    Science.gov (United States)

    Mangin, P H; Receveur, N; Wurtz, V; David, T; Gachet, C; Lanza, F

    2009-09-01

    Binding of von Willebrand factor to the platelet glycoprotein (GP)Ib-IX complex initiates a signaling cascade leading to integrin alpha(IIb)beta(3) activation, a key process in hemostasis and thrombosis. Interaction of 14-3-3zeta with the intracytoplasmic domain of GPIb appears to be a major effector of this activation pathway. The aim of our study was to determine whether other members of the 14-3-3 family bind to GPIb-IX. In this study, western blot analyses showed that platelets also contain the 14-3-3beta, 14-3-3gamma, 14-3-3epsilon, 14-3-3eta and 14-3-3theta isoforms, but lack 14-3-3sigma. Coimmunoprecipitation studies in platelets and CHO transfectants demonstrated that all six 14-3-3 isoforms expressed in platelets, including, as previously reported, 14-3-3zeta, bind to GPIb-IX. In addition, their interaction was found to critically require the same GPIbalpha domains (580-590 and 605-610) already identified as essential for 14-3-3zeta binding, in agreement with the conservation of the sequence of the I-helix among these different isoforms. Pull-down experiments indicated that all six 14-3-3 isoforms present in platelets bind to GPIbbeta. In contrast, deletion or mutation of the GPIbbeta intracytoplasmic tail did not affect the interaction of GPIb-IX with the 14-3-3 isoforms, questioning the importance of this domain. Our study suggests that, to inhibit GPIb-induced integrin alpha(IIb)beta(3) activation, a more appropriate strategy than inhibiting individual 14-3-3 isoforms would be to target the 14-3-3-binding motif on GPIb or, alternatively, the conserved 14-3-3 I-helix.

  12. X-RAY OUTFLOWS AND SUPER-EDDINGTON ACCRETION IN THE ULTRALUMINOUS X-RAY SOURCE HOLMBERG IX X-1

    International Nuclear Information System (INIS)

    Walton, D. J.; Harrison, F. A.; Miller, J. M.; Reis, R. C.; Fabian, A. C.; Roberts, T. P.; Middleton, M. J.

    2013-01-01

    Studies of X-ray continuum emission and flux variability have not conclusively revealed the nature of ultraluminous X-ray sources (ULXs) at the high-luminosity end of the distribution (those with L X ≥ 10 40 erg s –1 ). These are of particular interest because the luminosity requires either super-Eddington accretion onto a black hole of mass ∼10 M ☉ or more standard accretion onto an intermediate-mass black hole. Super-Eddington accretion models predict strong outflowing winds, making atomic absorption lines a key diagnostic of the nature of extreme ULXs. To search for such features, we have undertaken a long, 500 ks observing campaign on Holmberg IX X-1 with Suzaku. This is the most sensitive data set in the iron K bandpass for a bright, isolated ULX to date, yet we find no statistically significant atomic features in either emission or absorption; any undetected narrow features must have equivalent widths less than 15-20 eV at 99% confidence. These limits are far below the ∼>150 eV lines expected if observed trends between mass inflow and outflow rates extend into the super-Eddington regime and in fact rule out the line strengths observed from disk winds in a variety of sub-Eddington black holes. We therefore cannot be viewing the central regions of Holmberg IX X-1 through any substantial column of material, ruling out models of spherical super-Eddington accretion. If Holmberg IX X-1 is a super-Eddington source, any associated outflow must have an anisotropic geometry. Finally, the lack of iron emission suggests that the stellar companion cannot be launching a strong wind and that Holmberg IX X-1 must primarily accrete via Roche-lobe overflow

  13. Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer

    OpenAIRE

    Buchlis, George; Podsakoff, Gregory M.; Radu, Antonetta; Hawk, Sarah M.; Flake, Alan W.; Mingozzi, Federico; High, Katherine A.

    2012-01-01

    In previous work we transferred a human factor IX–encoding adeno-associated viral vector (AAV) into skeletal muscle of men with severe hemophilia B. Biopsy of injected muscle up to 1 year after vector injection showed evidence of gene transfer by Southern blot and of protein expression by IHC and immunofluorescent staining. Although the procedure appeared safe, circulating F.IX levels remained subtherapeutic (< 1%). Recently, we obtained muscle tissue from a subject injected 10 years earlier ...

  14. Microsatellite alterations in head and neck squamous cell carcinoma and relation to expression of pimonidazole, CA IX and GLUT-1

    International Nuclear Information System (INIS)

    Schutter, Harlinde de; Barbe, Barbara; Spaepen, Marijke

    2006-01-01

    Background and Purpose: Because the locoregional control for HNSCC is still disappointing, research efforts focus on the exploration of new molecular markers located in both tumour and microenvironment, which could help stratify patients. The aim of the present work was therefore first to assess microsatellite alterations and hypoxia in HNSCC as possible molecular markers. Second, a relation between both was investigated, as hypoxia is known to select for genetic alterations. Material and methods: Forty-eight patients with advanced HNSCC treated by surgery ± radiotherapy were included. MSI and LOH were investigated with microsatellite markers using automatic fragment analysis. The presence of hypoxia was assessed by immunohistochemistry for pimonidazole, CA IX and GLUT-1. The mutual relationship between MSI/LOH and hypoxia was evaluated. Results: No MSI was detected in this patient group. LOH occurred mostly on chromosomal arms 3p, 5q, 9p, 17p and 17q. Patients with LOH at D17S799, located in the near environment of p53, showed a higher CA IX expression (p = 0.01). Conclusions: LOH is a possible molecular marker in HNSCC. The positive correlation between LOH at D17S799 and CA IX is in full concordance with previous publications linking hypoxia to selective pressure on the p53 gene

  15. Efficiency Of The Photodynamic Therapy Using Gold Nanoparticles (np-Au) And PpIX Induced And Not Induced

    International Nuclear Information System (INIS)

    Maldonado-Alvarado, Elizabeth; Ramon-Gallegos, Eva; Arenas-Huertero, Francisco jesus; Reyes-Arellano, Alicia; Tanori-Cordova, Judith; Sanchez-Espindola, Maria Esther; Jimenez-Perez, Jose Luis; Cruz-Orea, Alfredo

    2008-01-01

    The use of gold nanoparticles (np-Au) to eliminate cancer has proved to be very effective due to the fact that cancerous cells accumulate it 600% more than healthy cells. In addition they have a high capacity of absorption and dispersion of light. Therefore, the effectiveness of photodynamic therapy (PDT) could be improved by the simultaneous use of np-Au and photosensitizes (Ps), emphasizing the high efficiency of the PDT to diagnose and to treat pre-malignant and malignant processes. The aim of this work was to determine the efficiency of PDT using np-Au and protoporphyrin IX (PpIX) induced and not induced by the δ-aminolevulinic acid (ALA). It were found the conditions of synthesis of hydrosoluble np-Au, and were characterized by transmission electronic microscopy (TEM) and UV-VIS spectroscopy. It was realized a kinetic by TEM to determine the cellular incorporation time of np-Au, the maximum incorporation of np-Au was of 16 h. PDT was applied using different doses of np-Au and photosensitizers. It was observed that the use of PDT simultaneously with np-Au did not increase the mortality of HeLa cells. In the case of C33, when PpIX not induced is used as photosensitizer simultaneously with np-Au, the mortality increased 20%

  16. Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX

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    Aikaterini Peperidou

    2018-01-01

    Full Text Available A series of carboxamide derivatives of 6- and 7-substituted coumarins have been prepared by an original procedure starting from the corresponding 6- or 7-hydroxycoumarins which were alkylated with ethyl iodoacetate, and the obtained ester was converted to the corresponding carboxylic acids which were thereafter reacted with a series of aromatic/aliphatic/heterocyclic amines leading to the desired amides. The new derivatives were investigated as inhibitors of two enzymes, human carbonic anhydrases (hCAs and soy bean lipoxygenase (LOX. Compounds 4a and 4b were potent LOX inhibitors, whereas many effective hCA IX inhibitors (KIs in the range of 30.2–30.5 nM were detected in this study. Two compounds, 4b and 5b, showed the phenomenon of dual inhibition. Furthermore, these coumarins did not significantly inhibit the widespread cytosolic isoforms hCA I and II, whereas they were weak hCA IV inhibitors, making them hCA IX-selective inhibitors. As hCA IX and LOX are validated antitumor targets, these results are promising for the investigation of novel drug targets involved in tumorigenesis.

  17. Modifier activity of the protoporphyrin IX of the clastogenic damage induced by gamma radiation in Drosophila melanogaster; Actividad modificadora de la protoporfirina IX del dano clastogenico inducido por radiacion gamma en Drosophila melanogaster

    Energy Technology Data Exchange (ETDEWEB)

    Martinez A, G. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)

    2007-07-01

    It has been demonstrated that the copper sodium chlorophyllin (CCS) it is a potent inhibitor of the one genetic damage induced by physical or chemical agents in systems like: bacteria, Drosophila, rainbow trout and mammals. Nevertheless it has been observed that under certain conditions it promotes it. In the laboratory of Drosophila of the ININ evidences have been obtained that the CCS increases the percentage of lethal embryonic dominant and post-embryonic induced by gamma radiation. One of the probable causes of this effect promoter, is the oxidizer stress that it could cause the metallic center of the CCS. The objective of this investigation it was the evaluation of the inhibitory action of the protoporphyrin IX (PP-IX) of the genetic damage induced by gamma radiation in the germinal line of Drosophila melanogaster. For such effect it was used the lethal dominant test by means of two protocols: one in the one that the PP-IX or CCS was administered to the females and the other one to the males. Females of genotype y/y and males of the canton-S stump were used. In both cases the males were treated with 40 Gy of gamma radiation. Its were count the embryonic lethal dominant (L-E) and those post-embryonic (L-PE) of the F1. The results indicated that after the one pretreatment with PP-IX to the crossed females with males treaties increase the percentage of L-E (P {<=} 0.001) and it diminished that of L-PE (P {<=} 0.001) compared with the sucrose control more radiation, however when it was pretreated with CCS also it was observed an increment in the percentage of L-E (P {<=} 0.001), but it doesn't present effect on that of L-PE. In contrast, when the males were pretreated, it was observed that the PP-IX tends to increase those L-E, but diminished the L-PE (P {<=} 0.05), however when it was pretreated with CCS was observed that increased the percentage of L-E (P {<=} 0.001) but diminished that of L-PE (P {<=} 0.001). It was concluded that none of the two pigments

  18. BAJA DE LA FECUNDIDAD Y FAMILIA URBANA EN REIMS EN EL SIGLO XVIII (1760-1802

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    ANTOINETTE FAUVE-CHAMOUX

    2011-10-01

    Full Text Available Normal 0 21 false false false ES-CL X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Bajo el Antiguo Régimen, existió un sistema de reproducción familiar específico de las ciudades. Esta es la conclusión que se puede sacar de las investigaciones realizadas hasta ahora sobre la transición demográfica en el medio urbano. Comparando Ginebra con Rouen, Alfred Perrenoud logró demostrar que la alta burguesía, tanto suiza como normanda, practicaba el control de la natalidad en 1650 (Perrenoud, 1990, y esto antes incluso que empezara a bajar seriamente la tasa de mortalidad (Bardet, 1990. Tanto en Rouen como en Ginebra, el control de la descendencia se extendió luego rápidamente al conjunto de la población, como lo demuestra la caída regular de la fecundidad. A estos dos principales modelos testigos del comportamiento innovador de algunas familias urbanas de Europa occidental en los siglos XVII y XVIII, cabe agregar el de Reims, ciudad de los Reyes de Francia ubicada en Champagne con 30.000 habitantes, famosa desde luego por sus vinos espumantes después de 1700, pero también por sus tejidos de lana. Bajo el Antiguo Régimen, existió un sistema de reproducción familiar específico de las ciudades. Esta es la

  19. La política urbana en un marco macroeconómico

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    Currie Lauchlin

    1993-12-01

    Full Text Available

    In this article the author explains how national policies interfer in the urban aspects of local policies, and emphasizes the need for government intervention in urban policies. Urbanization deepens the division of labor, widens the market, and increases the advantages of greater specialization. For these reasons, there is a direct correlation between urbanization and a  high income per capita Nevertheless, Currie expresses doubt about the benefits of economies of scale offered by urban growth in the absence of planning po1icies. The author points out that although economic growth tends to be se1f·perpetuating, this tendency can be accelerated or slowed down by these policies , The numerous and important economies of scale should be confronted with the diseconomies and the social costs which are implied by centralization. Planning which is directed to the design of "cities within cities" can contribute simultaneous1y to the goals of accelerating growth and obtaining, at the same time, a pleasant habitat for the urban population.

    En este artículo el autor explica la manera como la política nacional interfiere en los aspectos urbanos de la política local, y enfatiza sobre la necesidad del intervencionismo estatal en materia de política urbana. La urbanización profundiza la división del trabajo, amplía el mercado y aumenta las ventajas de una mayor especialización, razón por la cual existe una correlación directa entre urbanización y alto ingreso per cápita. No obstante, Currie pone en duda el beneficio de las economías de escala brindadas par el crecimiento urbano en ausencia de políticas de planificación si bien, señala el autor, el crecimiento económico tiende a ser autoperpetuante, esta tendencia puede

  20. PROFIL PERTANYAAN SISWA TUNANETRA KELAS IX SMPLB YKAB SURAKARTA DALAM PEMBELAJARAN MATEMATIKA

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    Siti Khoiriyah

    2015-10-01

    Full Text Available Abstract Thinking can be drilled to the student by developing question skill during teaching process. Personal life quality is determined from question quality; the more qualified a question the more success a person in life. Therefore, this study analyzed the students question to find out the students question quality. The subject of this study is IX class of SMPLB YKAB students Surakarta. The data was found by observation with handy cam. The data analysis was conducted through data reduction, data presentation and conclusion. From the data analysis was found the result that 89 questions from the students consist of 46 (51, 68 % questions that consist of C1, 2 elements (2,25 % questions that consist of C2, 25 elements (28,09 % questions that consist of C4 elements. Based on the finding of the study could be conclude that majority of visual impaired students in low categorize because of having C1, C2, and C3 elements.Keywords : visual impaired students question, mathematics learning.